text:
'CBGB' Trailer: Go Inside 'The Greatest Rock Club Ever' (Exclusive Video)
UPDATED: Alan Rickman leads an all-star cast in the true story of the famed New York nightclub, hitting theaters this fall.
Blondie, Talking Heads, The Ramones and Patti Smith are one step closer to hitting the big screen.
After months of teaser posters and on-set photos, CBGB, Randall Miller's film chronicling the rise of New York's famed punk rock music venue, is finally letting audiences inside the club with an official trailer. See The Hollywood Reporter's exclusive first look in the player above.
PHOTOS: 'CBGB' Character Posters: 10 A-Listers Play Joey Ramone, Iggy Pop and Blondie
Alan Rickman leads an all-star cast as Hilly Kristal, the financially unstable entrepreneur who opened the iconic club in 1973. CBGB, which stands for "Country Bluegrass Blues," ultimately closed in 2006 over a rent dispute but lives on as the largest music festival in New York City.
"Why would you save for your dreams?" Rickman, as Kristal, asks in the trailer. "Why not live your dreams?"
Among the acts teased in the preview are Talking Heads, Blondie, The Ramones, Dead Boys, The Police, Iggy Pop and Patti Smith Group, among others. Malin Akerman, Rupert Grint, Ashley Greene, Johnny Galecki, Ryan Hurst, Justin Bartha, Donal Logue and Bradley Whitford are among the film's stars.
The trailer ends on a kicker: "50,000 bands and 1 disgusting bathroom."
CBGB is slated to hit theaters Oct. 11. The film is produced by Unclaimed Freight and will be distributed in the U.S. by XLrator Media.
Email: email@example.com
Twitter: @SophieSchillaci
Never miss a story. Stay up-to-date with THR's Daily Headlines.
Must Reads
Hollywood Insiders Descend on Havana
CBS Entertainment Chief and "Loudmouthed Feminist" Nina Tassler Reveals the Strategy Behind 'Supergirl' Gamble
Paul Rudd and Marvel's Kevin Feige Reveal 'Ant-Man's' Saga, from Director Shuffle to Screenplay Surgery to Studio's "Phase Three" Plans
Comic-Con 2015: THR's Full Guide to Parties in San Diego
HBO's Real-Life Game of Thrones: The Fight to Stay Rich, on Top and Score Bill Simmons
Taraji P. Henson, Viola Davis and Drama Actress A-List Tackle Race, Sexism, Aging in Hollywood
Lena Dunham, Amy Schumer and Comedy Actress A-List in Raunchy, R-Rated Roundtable
Bob Odenkirk, David Oyelowo and Drama Actor A-List on Oscar Snubs, Bad Scripts and Getting Ignored by Robert Redford


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Results 1 to 7 of 7
Thread: Some good atelier schools?
December 11th, 2007 #1Registered User
- Join Date
- Oct 2007
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Some good atelier schools?
I'm looking for some good atelier schools. I've seen two or three but don't really know most of them by reputation just advertisement.I was wondering if anybody could recommend some good atelier/or illustration schools to check out.
I remember once running into a list of atelier schools,but i lost it.Anybody have a link to something like that?Sketchbook
Looking for mentor

subset: commoncrawl


text:
Purebred Lionhead Bunnies double maned (Dwarf size 3-4.5 lbs when mature) $40 each
'Miniature' Holland Lop Bunnies. Please email for faster with-in-one-day response. Advance reservation is recommended.
'Miniature' Holland Lops (smaller body size), 3.5 lbs - 4.5 lbs when mature.
'Regular' Holland lops have longer body size and heavier body weight - between 5 - 6 lbs.
Lion Lop Bunnies ...
Jul 1 -
Orlando :
Orlando - Other pets
I live on 326 in morriston I live 1 mile from marion county line I have a big yellow sign on side of highway eggs rabbits but now I have baby chicks selling for $ 3-5 baby bunnies $5.00 my phone is 352 239 7333 or 352 528 2848 my address is 20851 se 35th st morriston
Jun 23 -
Gainesville :
Morriston - Livestock
8 1/2 week old male bunny. He had been held daily since birth. We have been litter training them.
Please call, text, or email us for more information.
This ad was posted with the eBay Classifieds mobile app.
Jun 23 -
Miami :
Hollywood - Other pets
Pedigreed Male Holland Lop available. He is very sweet and has been held daily since birth. We have started litter training him and he is currently utilizing a litter box. If you would like additional information feel free to contact us. We are located in Pembroke Pines.
Jun 20 -
Miami :
Hollywood - Other pets
I have 2 bunnies for sale. both are boys and are black. They are 8 weeks old. asking $10 each or both for $15. Will make great pets.
Jun 17 -
Ocala :
Floral City - Other pets
This lil cutie pie is going to be teacup sized just like her daddy, she is short and cobby, and oh so adorable!
1 full year health guarantee on genetics, 1st shots, wormed and fecal tested as well as health certificate will be given when she goes home. Once deposited she will be taken into the vets and all completed. We are new to florida but are a vet referral to our home state.
She is being ...
Jun 17 -
Gainesville :
Interlachen - Dogs & puppies
3 baby bunnies for rehoming. They are all very small and tame. Two of them were born on 3/11/15 and another on 4/11/15
Delivery available
Call or text 305 479 0382
Jun 12 -
Miami :
Miami - Other pets
I'm moving and sadly have to rehome my bunny. He is 9 months old, super social, sweet and friendly. I want him to go to a loving home. Small rehoming fee.
This ad was posted with the eBay Classifieds mobile app.
Jun 12 -
Miami :
Fort Lauderdale - Other pets
Baby bunnies..3 different litters to choose from.
Cages for extra include: food , hay, bedding, water bottle
Jun 2 -
Gainesville :
Middleburg - Other pets
Beautiful baby dwarf lionhead bunnies call or text 3059702026
May 27 -
Miami :
Miami - Other pets
We are a very small rabbitry near Tampa Florida.
Holland Lop's are a dwarf breed and grown weight averages are in the 3 pound and 4 pound range. These are the smallest of the LOP eared rabbits and do have a dwarf gene.
We have a large variety of colors to choose from such as tort, black, and brokens.
Our prices START at $50.00 and go up depending on age, beauty, color, quality, and ...
May 26 -
Tampa Bay :
Tampa - Other pets
We raise netherland dwarfs, holland lops, mini rex and lionheads. Please "like" our facebook for updates on what we have available at .....https://www.facebook.com/AveryFarmsRabbitry
May 24 -
Gainesville :
Old Town - Other pets
Our bunnies are handled 2 x day, fed fresh grass and herbs to keep them healthy. Even our hay is Tifton 44. Our bunnies will be about 4 to 6 pounds of friendly, forever fluffy when grown.
Located in S.W. Bushnell kept under roof, open air rabbitry, 4 x 4 x 4 foot cages, in the shade. Worth a visit just for the smiles.
Have a Glorious day.
May 19 -
Ocala :
Bushnell - Other pets
Blue Eyed Baby Mini Lop Rabbits-We have two little does(girls) ready to go to their new homes, they are black with white noses, and bright blue eyes. Bunnies go quickly, especially blue eyed babies, we are located in Floral City(34436), we do not ship rabbits. These baby girls are $30 each,If interested call 352-419-4185
May 16 -
Ocala :
Floral City - Other pets
Male tort mini lop for sale. He's about 12 weeks old, the sweetest bunny ever. It breaks my heart cause I have to sell him but him and my other bunny aren't getting along anymore. I'd like to give him to a good family who will love him as much as I did. He's a free roam bunny so I would really prefer him not to live I'm a cage. No children please, bunnies are very fragile and need proper care ...
May 14 -
Orlando :
Clermont - Other pets
We have a 9 1/2 week old male black Dutch bunny available. He has been held daily since birth and is friendly. He is also utilizing a litter box.
Call us for additional information. Four...zero...eight...six...three...four...zero...one...two...three
This ad was posted with the eBay Classifieds mobile app.
May 9 -
Miami :
Hollywood - Other pets
Dont miss out on these beautiful bunnies asking $35 each or two for $50 call or text 3059702026
May 9 -
Miami :
Miami - Other pets
We'll be sending text message alerts for your subscription to


text:
1990 Buick Reatta ConvertiblePrice is recently reduced to $9995 Or Best OfferCall the seller directly - Frank 650-873 5809 or 208-402-6428 This Classic 1990... More
1966 Buick Gran Sport, This is a fully restored original with the original 401 Nailhead 325 HP, original automatic transmission, original factory air which is... More
Sleek beauty cloaks the sensational performance of the 1953 Buick Special Golden Anniversary. The Buick Special was an automobile produced by the Buick Motor Division... More
Owned by past AACA president and 50+ year BCA member Earl Beauchamp, Jr.! Original colors of Lassen Green over Red Leather with opera seats!... More
1936 Buick Century Sport Coupe - Model 66S with Rumble Seat & Dual side Mounts, Fisher Body Style #36457, one of 331 with dual... More
Buick 1937 Century Convertible Coupe. Frame off rotiserre restoration on mostly rust free car. All running gear restored including completely rebuilt 320 engine. Dark... More
1938 BUICK CENTURY COUPE, Model 66-S, top chopped 3.5", 500 cid Cadillac engine, fresh TH 400 transmission, ¹76 Camaro front clip, disc brakes, Scotts... More
1987 Buick Grand National. Molly Signature Series - Trunk tag signed by Molly Sanders. 2738 Miles. All Original. T-tops. No power options. T-Tops. Tilt... More
1941 Buick Super Model 56C Convertible Coupe Full, stunning older restoration Same California Owner for last 40 years 248CID Straight 8 DynaFlash motor, rated at 125HP at... More
I972 Buick Centurion 4554 Convertible Magazine Show Car -Full Cosmetic restoration including -top- interior- paint -tires- trunk and interior carpets -sill plates matching parade... More
Stunning show quality torpedo-styled 1941 Buick 46S Special two door coupe with no details left undone. Named "Bogie" for--well you know--Humphrey Bogart. Rare Aberdeen... More
1969 Buick Gran Sport GS 400, Fully documented Canada built car in true mint condition - as new in all aspects - all original -... More
1991 Buick Reatta Convertible, This is a very special one of a kind car. Because only 205 convertibles were delivered to dealerships, it was... More
1970 BUICK GRAN SPORT - Highly Collectable / Very Desirable - Correct Sea Mist Green with Pearl White Interior and White Top and Coordinating Convertible Boot -... More
1965 Buick LeSabre Custom Convertible This 1965 Buick left the factory heavily loaded with options. 7,000 miles since restored. When this car was restored a... More


text:
I'm trying in vain to get the php oci_* extensions installed on our server, but i've hit a brick wall.
So far i've done this:
- Installed oracle basic & devel libraries (v10.2)
- Installed php-pear package
Now I'm trying to install oci8 using "pecl install oci8" but I get an error message about "phpize" command not being found.
My googling tells me that that is caused by "php-devel" not being installed, so i tried various different yum searches, e.g. "yum search php-devel", "yum search php5-devel", "yum search php-dev", etc... none of which could find anything.
I eventually found a repository hosted by "utterramblings" which had php-devel. So, now when I do a yum search using that repository, it can find "php-devel":
php-devel.i386 : Files needed for building PHP extensions
But when I try to install it I get this:
Error: Package: php-devel-5.2.17-jason.2.i386 (utterramblings)
Requires: php = 5.2.17-jason.2
Installed: php-5.3.3-14.el6_3.i686 (@rhel-i386-server-6)
php = 5.3.3-14.el6_3
Available: php-5.2.13-jason.1.i386 (utterramblings)
php = 5.2.13-jason.1
Available: php-5.2.14-jason.1.i386 (utterramblings)
php = 5.2.14-jason.1
Available: php-5.2.16-jason.1.i386 (utterramblings)
php = 5.2.16-jason.1
Available: php-5.2.17-jason.2.i386 (utterramblings)
php = 5.2.17-jason.2
Available: php-5.3.2-6.el6.i686 (rhel-i386-server-6)
php = 5.3.2-6.el6
Available: php-5.3.2-6.el6_0.1.i686 (rhel-i386-server-6)
php = 5.3.2-6.el6_0.1
Available: php-5.3.3-3.el6.i686 (rhel-i386-server-6)
php = 5.3.3-3.el6
Available: php-5.3.3-3.el6_1.3.i686 (rhel-i386-server-6)
php = 5.3.3-3.el6_1.3
Available: php-5.3.3-3.el6_2.5.i686 (rhel-i386-server-6)
php = 5.3.3-3.el6_2.5
Available: php-5.3.3-3.el6_2.6.i686 (rhel-i386-server-6)
php = 5.3.3-3.el6_2.6
Available: php-5.3.3-3.el6_2.8.i686 (rhel-i386-server-6)
php = 5.3.3-3.el6_2.8
And to be honest, i'm not sure how to resolve that, presumably it has something to do with the version of php we have installed, but i'm not sure what I need to do to fix it.
These are our details:
Red Hat Enterprise Linux Server release 6.1 (Santiago) [32bit]
Could anyone please advise me as to either:
a) what I need to do to resolve that issue and get php-devel installed from that repo
b) point me in the direction of another repo which will allow me to easily install php-devel for our server
Thank you.


text:
Ryan Zimmerman 1B/3B/LF WAS 3 days ago
Zimmerman (foot) felt some discomfort while running during Wednesday's workout, Dan Kolko of MASN reports.
The foot discomfort caused Zimmerman to ease up on the running portion of his workout, which comes just one day after he logged a full workout. The fact that he struggled to get through consecutive days of workouts indicates that Zimmerman's progression will be slowed and tightly monitored for the time being. Once he's able to notch workouts on consecutive days with no setbacks, a rehab assignment would be his next step.
Ryan Zimmerman 1B/3B/LF WAS 4 days ago
Zimmerman (foot) went through a full workout Tuesday, Chelsea Janes of the Washington Post reports.
Zimmerman continues to progress in his recovery from plantar fasciitis, and he's scheduled to go through another full workout Wednesday. He remains without a timetable, but the next step in his recovery will be a minor league rehab stint.
Ryan Zimmerman 1B/3B/LF WAS 1 week ago
Zimmerman (foot) ran on a treadmill and took throws at first base Wednesday, Chelsea Janes of the Washington Post reports.
Zimmerman continues to work back from a foot injury, and he'll gradually increase his activity over the coming days. He remains without a timetable, and at this point it's unclear whether he's targeting a return before the All-Star break.
Ryan Zimmerman 1B/3B/LF WAS 2 weeks ago
Zimmerman (foot) took swings Tuesday for the first time since being placed on the disabled list, Mark Zuckerman of CSN Washington reports.
Zimmerman took the swings while wearing an orthotic in his shoe to help alleviate the pain from his plantar fasciitis. It still isn't clear when he will rejoin the Nationals, and this may be a chronic problem for the rest of the season, even if he returns in fairly short order.
Ryan Zimmerman 1B/3B/LF WAS 2 weeks ago
Zimmerman (foot) is without a timetable to return to the field, the Washington Post's James Wagner reports.
He said it has been "brutal" to sit around and rest his foot, which is affected by ongoing plantar fasciitis. It is probably worth continuing to stash Zimmerman in most formats, but the possibility remains that he will not get back to 100 percent this season as this has the feel of something that could be a chronic issue, at least in 2015.
Ryan Zimmerman 1B/3B/LF WAS 3 weeks ago
Zimmerman was placed on the 15-day disabled list Wednesday, William Ladson of MLB.com reports.
Zimmerman was suffering from ongoing foot problems, but it was believed he would just receive extra days of rest. It appears the plan has now changed, and the Nats will instead give him extended rest on the disabled list, while the club called up Matt den Dekker to take his place on the 25-man roster and to provide some extra depth in the outfield.
Ryan Zimmerman 1B/3B/LF WAS 3 weeks ago
Nationals manager Matt Williams acknowledged on Wednesday that Zimmerman would continue getting days off as necessary to manage the plantar fasciitis in his left foot, the Washington Post reports. "Number one concern for me is physical health and the foot and making sure that he's able to get out there and play and do what he wants to do. We monitor that every day and make decisions on it every day as well," Williams said.
Zimmerman is hitting just .209/.265.346 on the season with five home runs, and while he's been able to stay somewhat productive with 34 RBI, the lingering foot issue makes it tough to bank on him improving those numbers any time soon. In shallower leagues, the bench or even the waiver wire is probably the best place to leave Zimmerman until he shows signs of turning things around.
Ryan Zimmerman 1B/3B/LF WAS 3 weeks ago
Zimmerman, who continues to deal with plantar fasciitis, is out of the lineup Wednesday, MASN's Dan Kolko reports.
In addition to dealing with plantar fasciitis, Zimmerman has four hits in his last 46 at-bats, so the day off does not come as a surprise. Tyler Moore will get the start at first base Wednesday. It seems that the Nationals will let Zimmerman continue trying to play through the plantar fasciitis, but more scattered off days could be in his future.
Ryan Zimmerman 1B/3B/LF WAS 4 weeks ago
Zimmerman is back in the lineup Tuesday against the Yankees, batting fifth and playing first base.
Zimmerman sat out of Sunday's series finale and was replaced by Tyler Moore in the order. He is 4-for-13 in his career at Yankee Stadium with two doubles but will be facing Masahiro Tanaka for the first time Tuesday.
Ryan Zimmerman 1B/3B/LF WAS 4 weeks ago
Zimmerman is out of the lineup Sunday against the Cubs.
Zimmerman has made four straight starts at first base, but will get a regular day off in favor of Tyler Moore on Sunday afternoon. He's in the midst of a 1-for-21 slump, so a day to clear his head was likely in order.


text:
Yes, that's 100 million dollars of YOUR Money!
Obama's 100 Million Dollar Family Vacation…
This Australian's Message For America Will Make Liberals Cringe!
Young Black Woman Issues Blistering Takedown of George Takei & Other 'Leftist Racists'
Australian Author Explains What Makes America "Different"
These Americans Celebrate The 4th of July, But They Have No Idea What They're Celebrating
'Really, Erin?': CNN Host's Bizarre Question For Pamela Gellar Gets The Perfect Response
A Libertarian Explains How The Gay Marriage Ruling Hurts Religious Freedom
Parents Demand School Board 'Opt-Out' Of Sex Ed & Gender Identity Lessons…Then The Room Erupts!
Democrats: Taking Liberties To Make a Rainbow Clad Constitution
Do You Know This is NOT the Confederate Flag?
Ben Carson Will End the Income Tax. Hear How He Will Do It.
Goodbye To The First Amendment
Pin the Tale on the Donkey: Democrats' Horrible Racist Past
NBC Host Gets Shut Down After Asking Ted Cruz This Absurd Question About Marriage
They Told Her "God Doesn't Belong In America", Her Response Gave Me Chills
Black Power = Looting?
Jimmy Kimmel Catches Americans Lying About Their Knowledge Of Independence Day
Muslim Woman Vs. Abercrombie and Fitch


text:
A non-invasive method and system for assessing intraocular pressure (ICP) is disclosed. The method comprises the steps of measuring venous outflow pressure (VOP) using a venous ophthalmodynamometer device (vODM); measuring ophthalmic r central retinal arterial blood flow using color Doppler imaging device; and then estimating ICP using venous outflow data from the vODM and pulsatility and/or resistivity relationships derived from the Doppler imaging data. Further disclosed is a novel vODM for measuring VOP in low flow veins.
1. A non-invasive system for assessing intracranial pressure, the system comprising:
a venous outflow pressure (VOP) measuring device to provide venous outflow pressure (VOP) data;
an ophthalmic or central retinal arterial flow velocity measuring device to provide ophthalmic or central retinal arterial flow velocity data, respectively; and
a device for determining intracranial pressure (ICP) using venous outflow pressure (VOP) data and a characteristic of the ophthalmic or central retinal artery from ophthalmic or central retinal arterial flow velocity data, respectively.
2. The system as recited in
3. The system as recited in
4. The system as recited in
a differential variable reluctance transducer (DVRT) that can be used to apply a recordable, incremental load to a patient's orbit; and
a frequency analyzer that is in communication with the DVRT for receiving said recordable loading data for recordation.
5. The system as recited in
a device for freezing instantaneous load measurements that is in communication with the frequency analyzer, whereby activation of the device will freeze an instantaneous load measurement value at the instant that the retinal vein collapses so that said frozen value can be recorded by the frequency analyzer.
6. The system as recited in
7. The system as recited in
8. The system as recited in
wherein the Doppler probe can be applied to at least one of a patient's closed eyelids and a first ultrasound signal from said Doppler probe can provide an orbital scan image of said at least one of a patient's orbits to identify an optic nerve head of said orbit and a second ultrasound signal from said Doppler probe can provide a visual image of anterograde arterial blood flow in at least one artery of the patient's orbit to identify a vessel region to measure arterial blood flow velocity; and a third ultrasonic signal from said Doppler probe can provide continuous arterial blood flow velocity data at the identified vessel region.
9. The system as recited in
a display device for displaying the orbital scan image in two dimensions;
an input/output device for identifying the vessel region in said orbital scan image using the second ultrasound signal.
10. The system as recited in
11. The system as recited in
12. The system as recited in
13. The system as recited in
14. The system as recited in
15. The system as recited in
16. The system as recited in
17. The system as recited in
18. The system as recited in
a displacement transducer for applying pressure to a lateral sclera of the patient's orbit incrementally, the transducer further comprising:
a probe portion that includes a compression spring and an induction mechanism,
a plunger that is structured and arranged coaxial to to probe portion, wherein at least some portion of the plunger is disposed inside the probe portion and is, further, in communication with the compression spring, and
a removable pressure plate for applying incremental pressure to the patient's lateral sclera that is structured and arranged at a distal end of the plunger transducer, wherein as pressure is applied to the lateral sclera of the patient's orbit, the plunger displaces so as to compress the compression spring in the probe portion, which induces a current commensurate with the magnitude of displacement in the induction mechanism; and
a frequency analyzer that is in communication with the displacement transducer, wherein current induced by displacement of the plunger is output to the frequency analyzer as an output signal, which output signal can be processed by said frequency analyzer to provide venous occlusion pressure (VOP) data.
19. The system as recited in
20. The system as recited in
The present invention relates to methods of and systems and devices for predicting intracranial pressure. More specifically, the present invention relates to methods, systems and devices for predicting absolute intracranial pressure and changes in intracranial pressure non-invasively, by measuring retinal venous pressure and arterial pulsatility.
Continuous measurement and monitoring of intracranial pressure (ICP) for instantaneous (absolute) pressures as well as changes in pressure, especially among patients with, e.g., head injury, stroke edema, and acute intracranial hemorrhage, provides necessary, sometimes vital information on which medical and surgical treatment can be based. Heretofore and currently, invasive techniques have been used despite the many shortcomings of such practice. Continuous ICP measuring devices to manage intracranial hypertension (ICH) require invasive surgical boring through the skull to emplace them. Alternatively, another standard option for serial measurement of ICP is to repeat puncture of the lumbar dura, i.e., spinal tap, to measure the cerebrospinal fluid (CSF) pressure. For our purposes, CSF pressure is used interchangeably with ICP since both are essentially equivalent. Such procedures carry the risk of hemorrhage, malfunction, herniation and/or infection and, furthermore, are quite expensive. Representative examples of invasive ICP measuring devices and monitors include subarachnoid bolts, counterpressure epidural and subdural devices, e.g., Ladd or Camino fiberoptic monitors and Gaeltec sensors, intraparenchymal microsensors, and intra-ventricular catheters coupled to an external fluid pressure transducer.
Other approaches have been proposed to provide means to measure ICP non-invasively. Proposed techniques include measurement of tympanic membrane displacement in the ear, ultrasonic detection of cranial pulsations, and transcranial Doppler (TCD) ultrasonography of the middle cerebral artery. However, practical limitations prevent their use.
For example, the tympanic membrane displacement method is based on acoustic stapedial reflex that, in theory, can measure intracranial pressure indirectly by measuring displacement of the eardrum since ICP is transmitted from the CSF to the perilymphatic fluid of the scala tympana in the labyrinth. Drawbacks to this method include the indirect nature of measurement and the necessity of having a patent, unobstructed cochlear aqueduct.
TCD ultrasonography provides a real-time spectral waveform of blood flow velocity in intracranial vessels. However, with many head injury patients, flow velocities in unilateral intracranial vessels may either increase or decrease due to vasospasms, loss of normal cerebrovascular auto-regulation or other reasons. Furthermore, other physiologic variables, e.g., cardiac output, pulse rate, hematocrit, positive end expiratory pressure (if ventilated), and carbon dioxide tension can alter TCD parameters. Accordingly, TCD ultrasonography cannot predict absolute ICP from instantaneous readings. As a result, one can only infer trends. Finally, insonation of intracranial vessels requires technical training in order to deal with the complexity and anatomic variability of the cerebral vasculature.
Alternatively, use of extracranial ocular blood vessels to measure or assess ICP non-invasively as been suggested. Those skilled in the art recognize that increases in ICP affect the valveless venous system that drains the orbits. Indeed, venous distension due to increased resistance (or back pressure) to drainage is an obvious sign in late papilledema. Thus, those skilled in the art have sought means for assessing or measuring ICP using measurements of venous pressure in optic nerves.
Baurmann is believed to have been the first to suggest assessing ICP by measuring the pressure within the central retinal vein (CRV). The CRV caries venous blood away from the retina and toward the cavernous sinus of the brain. However, Baurmann's theory and findings, which appeared in the mid 1920's, have had to wait for technological advances for verification. Baurmann knew that CSF surrounds the optic nerve and therefore the optic nerve is subjected to ambient ICP. The extraocular segment of the CRV courses through the optic nerve, where the resistance to flow is dependent on the prevailing CSF pressure. This pressure is transmitted onto the thin wall of the vein through the nerve tissue. Further upstream, intraocular venous drainage from the retina and over the optic nerve head must overcome this resistance to outflow at its point of exit into the optic nerve. When ICP is excessive, the extraocular CRV and axons, coursing within the optic nerve, are tamponaded. The result is a rapid rise in intraluminal venous pressure and engorgement of the CRV at the optic nerve head (as well as papilledema if chronic). Distension and pulsation of the CRV branches can be visualized at this location by standard ophthalmoscopy, wherein the pressure gradient across the vein wall is the difference between intraocular pressure (IOP) and the intraluminal venous blood pressure.
The CRV pressure is usually equal to or higher than the ICP in the extraocular segment and, moreover, equal to or slightly higher than the IOP in the intraocular segment, otherwise no flow would occur between the compartments. When approximately equal to the IOP, the vein at the nerve head is found to pulsate; however, in other normal individuals it is not found to pulsate because the resting pressure is slightly higher than the IOP. According to Walsh, the major mechanism of the pulsations is partial collapse from variations in the IOP induced by arterial flow patterns on the extravascular vitreous.
If the IOP is now increased above the venous pressure, the vein will easily collapse. The manipulated IOP at the moment of venous collapse is defines as the venous outflow pressure (VOP). The VOP is, essentially, equal to the central retinal vein (CRV) pressure within the extraocular, intraoptic nerve segment. On the other hand, as ICP increases above about 20 cm H2O (intracranial hypertension), retinal vein pulsations, if present at rest, will first disappear. With further increases in ICP, the veins begin to engorge and become increasingly more difficult to collapse, requiring higher levels of IOP production to find the new VOP. The appearance of the CRV, therefore, reflects whichever compartment—the IOP or ICP—is higher.
Although the VOP is always found somewhat higher than the actual ICP, there is a direct correspondence between them. From the above discussion, the means to estimate actual ICP from graded increases in IOP is provided.
Others have also proposed noninvasive method for assessing ICP by venous ophthalmodynamometry (ODM). ODM refers to use of a calibrated compression-biased spring gauge device, or, alternatively, a vacuum cup, to manipulate IOP in ophthalmologic practice. ODM was pioneered by Bailliart, who, in 1917, observed that retinal arterial blood vessels, i.e., the central retinal artery, begin to pulsate at the point when IOP exceeds the diastolic arterial pressure and pulsations disappear when systolic pressures are reached.
Bailliart applied a hand-held device onto the anaesthetized lateral sclera of a patient and watched for the arteries to pulsate or cease pulsating. The device comprised a small pressure plate disposed at the end of a spring-loaded plunger. The spring was coupled to a dial gauge, which was calibrated to correlate applied pressure (in grams) to displacement of the plunger and compression of the spring. After the user applied the pressure plate/plunger to the patient's orbit (sclera), pressure was incrementally increased. This caused the spring to compress in a manner linear with the rise in IOP. The user continued to apply pressure until he or she observed pulsations come and go and finally loss of arterial color.
Using a nomograph and a baseline IOP readings taken using a tonometer while the patient was resting, one can convert the pressure on the dial gauge at the instant of arterial wall changes as seen through an ophthalmoscope, to the actual induced IOP. Although sophisticated enough to measure pressure in the arterial range, which is not correlated with ICP, the Bailliart device is not sensitive enough to determine the anticipated direct relationship between ICP and lower retinal pressures.
The inventor incorporates by reference herein an article entitled "Flow velocity and pulsatility of the ocular circulation in chronic intracranial hypertension," which appeared in Acta Neurologica Scandinavica 2002: Volume 105, pps. 431–440, that he co-authored. In the article, the authors reported that, "orbital arterial velocities and pulsatility/resistance indices are significantly affected by ICP changes in chronic raised ICH." However, that being said, the authors further observed and reported a non-linear, bi-modal relationship between pulsatility/resistance indices, e.g., Gosling's Pulsatility Index (GPI), and ICP for both flow measurements for the central retinal artery (CRA) and the ophthalmic artery (OA). In summary, the authors concluded that, the biphasic relationship is a function of both the CSF, i.e., whether mild-to-moderate or severe-to-extreme, and compensatory regional changes in arterial flow pattern. As a result, the Ocular Color-Doppler sonography could not be used to predict ICP in chronic raised ICP.
More recently, Firsching, et al. reported a correlation between VOP and ICP using an ODM device fashioned by themselves for non-invasive assessment of IOP. First, Firsching, et al. established a baseline IOP using a tonometer. Subsequently, Firsching, et al. attached a suction cup to a patient's lateral eye bulb and applied negative pressure, i.e., a vacuum, to the eye bulb, to increase IOP. As the pressure was applied, Firsching, et al. observed the CRV to the point of collapse using indirect funduscopy. At the instance of vein collapse, the ODM measurement and ICP were recorded simultaneously. The ODM measurement, further, was converted to IOP, which was equated to VOP. Firsching, et al. then plotted VOP versus ICP and through regression analysis derived an empirical, linear formula for assessing ICP.
The assessment technique developed by Firsching, et al., however, did not address or take into account the contribution to venous outflow pressure made by retinal arterial hemodynamic parameters, e.g., perfusion (flow volume), velocity, pressure, pulsatility, and resistance to flow. Furthermore, indirect funduscopy requires considerably more technical experience to operate than direct ophthalmoscopy as used herein. Moreover, application of a suction cup-based ODM is also more technically demanding, requires a more cumbersome apparatus, and is more uncomfortable to the patient than methods described herein.
In a first embodiment, the present invention provides non-invasive method of assessing at least one of an absolute and a change in intracranial pressure (ICP), the method comprising the steps:
measuring venous outflow pressure (VOP);
measuring ophthalmic or central retinal arterial blood flow velocity; and
determining intracranial pressure (ICP) using venous outflow pressure (VOP) data and a characteristic of ophthalmic artery from the ophthalmic or central retinal arterial velocity data.
Preferably, VOP is measured using a venous ophthalmodynamometer that comprises a displacement transducer in combination with a frequency analyzer and arterial blood flow velocity is measured by color Doppler imaging. More preferably, pressure is applied to the anesthetized orbit of a patient using the pressure plate of the displacement transducer, which induces a current that is transmitted as an analog signal to the frequency analyzer. The frequency analyzer receives the analog data, which it stores, manipulates, and displays as VOP.
Furthermore, preferably, color Doppler imaging provides a real time ultrasonic, signal of arterial blood flow and direction in a discrete arterial vessel in the patient's orbit. These data are used to calculate pulsatility and resistance indices, which, in turn, can be used in conjunction with the VOP to refine the estimate of ICP.
In a second embodiment, the present invention provides a non-invasive system for assessing at least one of an absolute and a change in intracranial pressure (ICP), the system comprising:
a venous outflow pressure (VOP) measuring device;
an ophthalmic or central retinal arterial blood flow velocity measuring device; and
a device for estimating intracranial pressure (ICP) using venous outflow pressure (VOP) data and a characteristic of the ophthalmic or central retinal artery from the ophthalmic or central retinal arterial flow velocity data.
Preferably, the system uses a venous ophthalmodynamometer, comprising a displacement transducer in combination with a frequency analyzer, to measure VOP. Arterial blood flow velocity is measured by color Doppler imaging. More preferably, the pressure plate of the displacement transducer applies graded pressure to the lateral sclera orbit of a patient, which induces a current in an induction device commensurate with the magnitude of displacement. The induced current provides an analog signal that is transmitted to the frequency analyzer. The frequency analyzer receives the analog data; digitizes the data; and further stores, manipulates, and displays the data as VOP.
Furthermore, preferably, a color Doppler imaging (CDI) device comprising a Doppler probe and a spectral analyzer, is used to provide a real time ultrasonic, signal of arterial blood flow in a discrete arterial vessel in the patient's orbit. These data are used to calculate pulsatility and resistance indices, which, in turn, can be used in conjunction with VOP data to refine the estimate of ICP.
For a fuller understanding of the nature and desired objects of the present invention, reference is made to the following detailed description taken in conjunction with the accompanying figures wherein like reference characters denote corresponding parts throughout the several views and wherein:
In a first embodiment, the present invention comprises a method of assessing intracranial pressure (ICP), which is shown in a flow diagram in
Color Doppler imaging (CDI) is known to the art and the mechanics of a CDI device 22 will not be described in great detail herein except as they relate to the present invention. The inventor used a bulky Siemens Q 2000 or Elegra unit 22 having a 7.5 MHz, pulsed-wave, linear transducer, i.e., Doppler probe 21, which unit or like units is common to most hospitals, to measure arterial blood flow velocities of supine patients. However, the invention should not be construed as being so limited as portable transcranial Doppler (TCD) systems are commercially available, e.g., the Neuroflow™ TCD system manufactured by Neuroguard of Fremont, Calif., that one skilled in the art could adapt for use with the system 20 and method of the present invention.
The CDI device 22 is in communication with a linear transducer (or probe) 21 via an inlet/outlet (I/O) port 23. Preferably, the Doppler probe is in the form of a linear transducer 21 is positioned manually near one of the orbits 25 of a patient. More preferably, the Doppler probe 21 can be applied to the closed eyelid 26 of a supine patient. In one aspect of the present invention, ultrasound levels in the about 50 to about 100 MW/cm2 range and more preferably at a level of about 71 MW/cm2 can be used at about 50 percent power. In a second aspect of the present invention, the CDI device 22 is multimodal, and one mode (B-mode) of the device 22 can provide an image of an organ; another mode (C-mode) of the device 22 can provide a visualization of the anterograde arterial flow; and another mode (D-mode) of the device 22 can measure arterial flow velocities. Those skilled in the art can adjust the Doppler angle as desired to achieve maximal velocity signal, however.
More preferably, the Doppler probe 21 and CDI device 22 are structured and arranged to send a visual image, e.g., two-dimensional, black and white image, of the optic nerve head of the eye in the orbit 25 to the CDI device 22, e.g., using the B-mode; to send a real time, spatially visualized color Doppler image of anterograde arterial flow in the B-mode image, e.g., using the C-mode; and to send a pulsed-wave, ultrasound signal of the arterial blood flow velocity and direction, e.g., using the D-mode. The D-mode signal can be digitized and used to calculate Doppler frequency shifts that, in turn, can be used to calculate arterial systolic and diastolic blood flow velocity. This preferred ultrasonography provides a real-time spectral waveform measurement of blood flow in ocular arteries.
In another aspect of the present invention, the CDI device 22 includes software and/or hardware to display the image from the linear transducer 21 on a display (not shown), e.g., as a two-dimensional orbital B-scan. An input/output (I/O) device(s) (not shown), e.g., a mouse, further, can be in communication with the CDI device 22 to enable the user to move a cursor on the screen displaying the two-dimension orbital B-scan to pinpoint a region or point of interest from which arterial blood flow measurements can be made. The central retinal artery (CRA) and central retinal vein (CRV) typically are located for Doppler measurement purposes approximately 2 mm behind the optic nerve head and sounding depth for the CRA is between about 25 and about 30 mm. Alternatively or additionally, the ophthalmic artery (OA) (nasal side) is located about 15 mm behind the eye nasal to the optic nerve and sounding depths are between about 40 and about 50 mm. Preferably, the cursor is disposed at one or more of these locations.
In a D-mode, the Doppler probe 21 sends continuous ultrasound analog signals of Doppler frequency shifts in the blood coursing through the CRA or OA, which produce spectral, flow measurement data. Although the CRA and OA are discussed herein as the best mode, the invention is not to be construed as being limited to measurements made in just those two arteries. For example, the posterior ciliary arteries also can be used for purposes of blood flow measurement. Software and/or hardware in the CDI device 22 can display these flow measurement data as velocity versus time graphs.
In a second step, the blood flow measurements from the CDI device 22 can be used to extract arterial blood flow parameters in STEP 2. Preferably, software and/or hardware, e.g., a spectral analyzer (not shown), installed in or in communication with the CDI device 22, can digitize the ultrasound arterial blood flow signal, e.g., ultrasonic D-mode, signal and determine therefrom peak systolic velocity (PSV), end diastolic velocity (EDV), and mean arterial velocity (MAV) of the blood flow for at least one of the CRA and the OA. Generally, blood flow measurements from the CRA provide a better predictor of ICP than OA measurements; however, OA measurements provide acceptable data. These data can, further, be output to a system integrator 29.
In STEP 3, the system integrator 29 can use these data to calculate at least one of Gosling's Pulsatility Index (GPI), which is defined by the equation:
The embodied method further comprises the step of measuring venous outflow pressure (VOP) STEP 1 c. Preferably, VOP is measured simultaneously or immediately after the arterial blood flow velocity is measured STEP 1 a. More preferably, VOP can be measured using a direct ophthalmoscope (not shown) of a type that is well known to the art in combination with a portable venous ophthalmodynamometer (vODM) 30 of a type and in a manner described in greater detail below. Succinctly, pressure is applied to the lateral sclera of a patient's orbit 25 until the patient's CRV or other retinal vein occludes, or collapses, the pressure at which corresponds to the VOP.
Preferably, as pressure is applied to the patient's orbit 25 to the point of collapse, the CRV is directly monitored visually, e.g., using a hand-held ophthalmoscope. In contrast to indirect funduscopy, which is the observation means employed by Firsching, et al., use of an ophthalmoscope in the embodied method is simpler, requiring less training to master, and provides direct, as opposed to indirect, observation of the orbit 25.
More preferably, pressure is applied to the patient's orbit 25 to the point of collapse using a displacement transducer 32 and the CRV is monitored visually using an ophthalmoscope. The displacement transducer 32 and the ophthalmoscope are hand held devices that can be operated by a single user or multiple users working in tandem. At the point or collapse of the CRV, pressure is no longer applied to the orbit 25 and the force, typically measured in grams (g), at the point of occlusion can be digitally recorded. To facilitate measurements, the vODM 30 can further comprise a foot pedal 39, which the user can activate, e.g., manually or with his or her foot, when he or she observes occlusion of the CRV, thereby automatically freezing and storing the VOP at the point of collapse.
In a preferred embodiment, use of a vODM 30 in combination with an ophthalmoscope to measure VOP includes first anesthetizing the orbit 25, e.g., using topical proparacaine HCI 0.5% dilated with Tropicamide (Midriacyl, 1%), and dilating the patient's pupil pharmacologically so that application of a pressure plate 38 of a displacement transducer 32 does not produce an involuntary reflex, e.g., blinking, of the orbit 25. Once the orbit 25 is anesthetized and the pupil dilated, a sanitized pressure plate 38, which is structured and arranged at the distal end of the displacement transducer 32, can be applied to a patient's orbit 25 and pressure can be applied to a patient's orbit 25 incrementally. As pressure is applied to the orbit 25, the user can visually monitor one of the retinal veins through the unoccluded cornea and pupil, well out of the way of the pressure plate 38. Application of force continues incrementally to the point of collapse, or occlusion, which is observable with the ophthalmoscope. Activation of the foot pedal 39 at the point of occlusion facilitates recording the instantaneous pressure at collapse. To provide an average VOP, this procedure can be repeated several times.
VOP (in mm Hg) can then be calculated as a function of the applied force (in grams) at the point of collapse and resting IOP, which can be measured, e.g., using a tonometer, contemporaneously with but prior to VOP testing while the patient is in a supine or "resting" position STEP 1 b.
A preferred embodiment of a vODM 30 will now be described. Referring to
In one aspect of the embodied vODM 30, the DVRT 32, having a 1.5 μm resolution, is in communication with the frequency amplifier 38, e.g., via a signal cable 31. One or more cable connections 33 are disposed at a proximal end of the displacement transducer 32. The signal cable 31 can be removably connected to at least one of the one or more cable connections 33 and, further, is removably connectable to an input/output port 35 on the frequency amplifier 38.
The DVRT 32 further comprises a handheld probe portion 34, a movable plunger, or piston, 36, and a convex scleral pressure plate 38. The scleral pressure plate 38 is disposed at a distal end of the DVRT 32, or, more specifically, at the distal end of the plunger 36. The pressure plate 38 has a standardized, convex shape and a standardized surface area. Preferably, the pressure plate 38, e.g., of a type manufactured by Mitutoto Co., can be manufactured with a 6.3 mm diameter and a surface area of 0.33 cm2 using heat resistant metal, ceramic, and like materials. Because the pressure plate 38 physically contacts and applies incremental pressure to the scleral lateral of a patient's orbit 25, the pressure plate 38 should be easily sterilizable and, preferably, autoclavable. More preferably, the scleral pressure plate 38 is removably attachable to the end of the plunger 36, e.g., using a cavity structured and arranged with inner threadings so that corresponding threadings structured and arranged on the outer surface of the plunger 36 can frictionally engage the threadings in the cavity of the pressure plate 38; using outer threadings structured and arranged so that the pressure plate 38 can be removably attached in a cavity (not shown), having corresponding threadings, that is structured and arranged at the distal end of the to the plunger 36; or using an interference fit between the plunger 36 and the pressure plate 38. The removable feature allows users to remove pressure plates 38 after each use for autoclaving to facilitate sanitization.
The probe portion 34 and movable plunger 36 are structured and arranged coaxially so that the moveable plunger 36 can displace freely in an axial direction relative to the handheld probe portion 34. A stop mechanism 37 can be disposed at a discrete location on the shaft of the plunger 36 to prevent excessive stroke, i.e., plunger displacement beyond a desired limitation. In one aspect of the present invention, the stop mechanism 37, e.g., a washer ring, O-ring, and the like, can be slightly larger in outer diameter than the diameter of the opening 35 in the probe 34 through which the plunger 36 travels so that the stroke of the plunger is arrested when the stop mechanism 37 contacts the probe portion 34 at the opening 35. The plunger 36 used by the inventor in his studies was 3.3 cm long with an 8 mm stroke.
A compression spring (not shown) can be structured and arranged in the interior of the probe 34 so as to be in communication with the plunger 36. The compressive spring is structured and arranged in the interior of the probe 34 to enable force measurement for displacement of the plunger 36. An inductive mechanism, e.g., transducer coils, (not shown) also can be structured and arranged in the interior of the probe 34 so that displacement of the moveable plunger 36 induces an electrical signal whereby the greater the displacement, the greater the current and, therefore, the voltage. Thus, axial translation and, therefore, through inductance, signal voltage are a function of applied pressure.
Preferably, in operation, as the sclera pressure plate 38 is applied incrementally to the lateral sclera of a patient's orbit 25, the plunger 36 displaces axially in the direction shown by the arrow in
In a preferred embodiment, a foot pedal freeze switch 39, e.g., of a type like the Treadlite II foot pedal, is in communication with the frequency amplifier 38. More preferably, the foot pedal freeze switch 39 communicates with the frequency amplifier 38 via a signal cable 41 that is removably connectable to the frequency amplifier at an I/O port 45 provided for that purpose. The foot pedal freeze switch 39 is in communication with the frequency amplifier 38 for the purpose of transmitting a signal to the frequency amplifier 38 that causes the frequency amplifier 38 to record and store the digital DVRT 32 output signal data at the instant of the signal from the foot pedal 39. In this manner, when a user observes occlusion of a retinal vein, he or she can activate the foot pedal freeze switch 39, which causes the frequency amplifier 38 to record and save the applied pressure in grams and VOP in mm Hg at the instant of occlusion.
Referring to
Preferably, the frequency amplifier 38 can store the digital data in internal and/or external memory that is provided for that purpose. More preferably, the frequency amplifier 38 also can transmit digital data, e.g., via an RS-232 I/O port 45, automatically or on demand to a system integrator 29. Such transmission can be direct from the frequency amplifier 38 to the system integrator 29, or, alternatively, via a microprocessor 48, which is in communication with both the frequency amplifier 38 and the system integrator 29. At least one of the microprocessor 48, the frequency amplifier 38, and the system integrator 29 includes a central processing unit, I/O devices, and memory storage means, e.g., random access memory (RAM), read-only memory (ROM), cache memory, and the like, to drive the frequency amplifier 38, the CDI device 22, and the system integrator 29.
The frequency amplifier 38 requires a 12-volt (DC) power source, which can be provided by a transformer (not shown), e.g., a medical grade, isolation transformer, or, more preferably, with replaceable batteries (not shown). A power port 44 can be provided on the back side 47 of the conditioning box 40 if a transformer is used and or, a battery pack (not shown) can be provided in the conditioning box 40 wherein a plurality of batteries, e.g., D cell batteries, can be removably inserted in a manner that is well known to the lesser arts. Preferably, the frequency amplifier 38 includes one or more I/O ports, e.g., an RS-232 port 45, whereby signals and data can be transferred to and from the system integrator 29 and/or a microprocessor 48 that is in communication with both the frequency amplifier 38 and the system integrator 29.
In STEP 4, at least one of the system integrator 29 and/or the microprocessor 48 in communication therewith receives and processes digital data from the frequency amplifier 38 and the CDI device 22 and outputs the data as, e.g., at least one of VOP (in mm Hg), CRA/OA blood flow velocities (in cm/sec), GPI, PRI, and estimated ICP (in mm Hg). The system integrator 29 can include its own internal microprocessor or, alternatively, be in communication with a remote microprocessor.
Having described the methods, systems, and devices of the present invention, we will now provide examples of results using the same. Reference will be made throughout this discussion to
The inventor performed non-invasive measurements (n=22) of VOP and transocular arterial blood flow velocity on six patients. The ICP, which was measured invasively by ventriculostomy transducers for comparison purposes, of the patients varied between about 0.5 and about 48 mm Hg. As a starting point, the inventor observed a direct and linear relationship between ICP increase and VOP measured using the vODM described above, which is shown graphically in
Some of the variability in venous data was believed to have been derived from localized, arterial-based factors. However, when arterial effects were analyzed, there was a poor correlation between ICP and mean arterial velocity for both the CRA and OA. Diastolic velocities provided equally bad predictors. However, a significant inverse relationship between the pulsatility amplitude of the CRA, which is defined as the
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I have several versions of Visual Studio installed on my system (2005, 2008 and 2010). Also I have a Visual Studio 2005 (8.0) C++ project (vcproj) and solution (sln) associated with it. When I run the following command
msbuild helloworld.sln
the msbuild of version 4.0 is called and then it invokes vcbuild.exe from Visual Studio 9.0 directory. This leads to an error
vcbuild.exe : error VCBLD0010: Project 'XYZ' requires upgrade. Use'vcbuild /upgrade' or 'devenv /upgrade' to upgrade the project.
On the other systems MSBuild 4.0 invokes vcbuild.exe from Visual Studio 8 directory and the project successfully compiles. I cannot figure out why on my system the vcbuild 9.0 invokes instead of 8.0. Do anybody have an idea how to troubleshoot this issue?


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Parent Notification Letter for NCLB Report Card February 3, 2012 Dear Parent: Charlotte Independent School District is sharing this information about the district and your child's campus with you as part of its obligations under the federal No Child Left Behind Act of 2001 (NCLB). NCLB Report Cards for the state as a whole, the district, and each of the district's campuses are now available on the district's web site at this link: www.charlotteisd.net NCLB Report Cards for the state as a whole, all school districts and charter schools, and all campuses are also available on the Texas Education Agency's NCLB web site at http://www.tea.state.tx.us/index4.aspx?id=4638&menu_id=798. Information on these report cards includes: •Assessment results for the LEA and campuses in the aggregate and disaggregated by race/ethnicity, gender, disability status, migrant status, English proficiency, and economically disadvantaged showing two-year trend data (across the most recent previous two school years) for each subject and grade tested: • by performance level, • with a comparison between annual objectives and actual performance for each student group, and • the percentage of each group of students not tested. •Graduation rates for secondary school students. •Performance of school district and campuses on adequate yearly progress (AYP) measures. •Number and names of Title I schools identified as in need of improvement, including the stage of improvement and AYP indicator missed by any schools identified for improvement. •Professional qualifications of teachers in the LEA and campuses, including the percentage of teachers teaching with emergency or provisional credentials and the percentage of classes in the LEA and campuses that are not taught by highly qualified teachers, including a comparison between high-and low-poverty campuses within the LEA. If you have difficulty accessing the information from the web site, hard copies of the reports are available through the campus principal's office. If you have questions about the information, please contact the appropriate campus. Sincerely, B. Starkweather, Superintendent
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Former FBI Director Louis Freeh to Speak at 120th Commencement
The Honorable Louis Freeh, former FBI director will address Saint Anselm College's class of 2013 at the 120th commencement on Saturday, May 18.... Read More
Juried Fine Arts Student Exhibition to Open at Chapel Art Center
The Chapel Art Center presents the 12th annual Juried Fine Arts Student Exhibition featuring 29 student-pieces.... Read More
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During the month of April, the Office of Career Services is hosting 13 professional development events for students. ... Read More
Fine Arts Professor Awarded Fellowship in Italy
Professor Katherine Bentz, of the Fine Arts department, has been awarded a prestigious fellowship in Florence for the 2013-2014 academic year.... Read More
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Saint Anselm College's Holy Week schedule... Read More
Saint Anselm Named to President's Honor Roll for Service
Saint Anselm College has been named to the 2013 President's Higher Education Community Service Honor Roll, a national honor that recognizes Saint Anselm College's commitment to service and service-based learning.... Read More
College Marks Father Jonathan DeFelice's Retirement
As Father Jonathan DeFelice, O.S.B., prepares to retire after 24 years as president of Saint Anselm College, the college will hold a variety events in April.... Read More
Education Students Take Part in Mock Interviews
Saint Anselm students in the field of education received an education of there own during the department's annual mock interview event with area principals. ... Read More
Benedictine Heritage Week
As a Benedictine college, Saint Anselm celebrates Benedictine Heritage Week March 18 - 22 with a variety of events for the college community.... Read More
Institute Hosts American Election 2012: Contexts and Consequences Academic Conference
Saint Anselm College Politics professor Peter Josephson Ph.D., and Theology professor Ward Holder Ph.D., held The American Election 2012: Contexts and Consequences academic conference at the New Hampshire Institute of Politics & Political Library on March 15-16.... Read More


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Engaging Students in Active Learning Worshop 6
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teachers examine the elements of authentic instruction and cooperative learning to identify ways of engaging students in social studies content. They review the importance of questioning in relation to higher-order thinking and explore classroom strategies to stimulate
thinking and bring social studies concepts to life for their students.
Making Connections Workshop 8
How do we connect social studies to life beyond the classroom? In this
culminating session, the teachers demonstrate the major concepts they've learned throughout the workshop in social studies unit presentations.
Classroom video segments further illustrate effective ways of bridging
social studies concepts and the world beyond the classroom, and show creative examples of teaching and learning.
Student Diversity Workshop 5
The varied viewpoints necessary for valuable class discussions are
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experiences. They examine the worth of using the lens of multiple
perspectives to examine a work of literature, and offer suggestions for ways to encourage each student to contribute to the ongoing class


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Google Glass XE18.3 update begins rolling out
Google Glass hasn't seen very much attention during Google I/O, however there is a bit of good news in terms of a new update. It seems Google has begun rolling out the XE18.3 update. We first saw details on this update when Google detailed the hardware changes for Glass earlier in the week.


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Overall score
would recommend to a friend.
Reviewer score
Would not recommend
ok for a one night stay
We were only there for one night to catch an early flight in the morning. When calling hotel, the person answering the phone was extremely rude. I would not stay here again. The room had an odd odor. I was itchy the entire time I was there.
You definitely get what you pay for
I think the motel management must have a special room set aside for those that purchase the room online. Some issues I had with the motel are the sliding window in the bathroom would not lock, there was quite a bit of hair on the top of the
toilet and on the bathroom door, the a/c wall unit didn't work (I just wanted to turn on the fan part of the a/c wall unit for noise to drown out the traffic noise outside), there was not an alarm clock, and the room had a bit of an odor. I can't complain too much though because the room was a pretty good deal for a frugal traveler.
Would recommend
Perfect for what we needed!
Experience was great for what we needed. Stopped by at 11 checked in, didn't check out the room, left straight for Boston for Sox game, didn't wanna stay in Boston so stayed here for the night for a low price and just a place to sleep. It worked
out perfect. D&D across the road for quick breakfast. The staff was friendly.
This was one of the worse hotels that I have ever stayed in. First off we had the corner room, ya you read right, corner room, the key to the room barely opened the door, every time you would take a shower it would smell like someone urinated in
the bathroom, the shower curtain was not plastic, cloth only and not washed on a regular basis. Low quality shampoo and conditioner, oh and try wiping your butt with cardboard because that is what it felt like with the kind of toilet paper they provided us. And what kind of hotel room doesn't have a bible in it? This place was a complete dump!!
Nice weekend getaway
Our stay was nice. We just wanted a place to sleep and this served its purpose. The staff could have been friendlier but for the money not a bad stay. I would go back again.
Fall fair expedition
Overall the value of the stay here was unbeatable for a short family get-a-way. Great location for local fairs and sightseeing, lots of shops, and places to eat that would fit any budget. Only one complaint, The room was noisy- located on the main
road and a busy street at all hours!
Could be worse
The office person continued to talk on the phone and just handed the key after I filled out the registration card. Fridge smelled like mold, even with the Baking soda box. Check out was pretty much, hand over the key and 'Bye'.
Dunkin Donuts was across the street.
a tired hob beeb hovel
i picked the cheapest price, shame on me
the mall was close
Decent Stay
It is a nice motel, good for a one night stay. We arrived at 9pm, checked in, went to bed, got up at 5am and left. The clerk was friendly, the room was clean, and there was no noise. Excellent for an overnight but maybe not for a longer
Also, the best priced motel in the city.
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Revisiting Arrested Development
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May 19 2013, 08:19 PM
Spot's Meow
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Location: California
Re: Revisiting Arrested Development
I just started season 3, and even though I'm only three episodes in, it already has a different feel to it than the first two seasons. The jokes are more explicitly sexual (as opposed to hinting at it) and some of the dialogue just feels...different. Not necessarily worse, just not the same anymore. I still enjoy the show though.
Time present and time past
are both perhaps present in time future.
And time future contained in time past.
T.S. Eliot
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does this software have i message
- Asked by Sajid C from Croydon
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1 Answer from the Community
No. iMessages is for OS 10.8 "Mountain Lion". It is not for OS 10.6 "Snow Leopard".
iMessages and FaceTime replace iChat that was for earlier OS X versions such as Snow Leopard.
iChat was for messaging and talking face-to-face between Macs only.
iChat allowed for "conference video calls" between up to 4 users using Macs, whereas Facetime allows video calls between 2 users using Mac, iPhone, iPad and iPod touch.
iMessages allows for messaging between Mac, iPhone, iPad and iPod touch. iMessages also allows one to quickly switch to Facetime.
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The Increasing Visibility of Driver Health
Potential for Vicarious Liability Under the Graves Amendment
FMCSA's Certified Medical Examiner Mandate to Start on May 21, 2014
Understanding Supplemental Spousal Liability Insurance in NY
PennDOT to Increase Number of Pennsylvania Bridges with Weight Restrictions
Federal Court Upholds Majority of Hours-of-Service Rule
New Jersey to consider allowing police to search cell phones to combat distracted driving
Court Schedules Arguments on FMCSA's New Hours of Service Rule on March 15, 2013
Doing Business In Canada
Who pays for road damage in Pennsylvania after ACT 13?
Marcellus gas fuels Natural Gas Vehicles
Google real estate director John Igoe - San Francisco Construction & Development Summit
In the modern era, the world moves fast—aided by technology that is constantly evolving and changing our relationships with each other and with the world around us. Technological developments challenge state and local...more
In This Issue:
- Construction Contract Claims Against a Third-Party Lender? The Unforeseen Consequences of a Standard Practice:
For those of us who commonly represent lenders, there is nothing more unsettling...more
Lady Macbeth tells her troubled husband, "What is done is done" and later says to herself "and cannot be undone." This is the outcome in Hillcrest Property, LLP v. Pasco County, 754 F. 3d 1279 (11th Cir 2014) and apparently...more
The City of Temecula is moving forward with the French Valley Parkway. The project involves constructio of a new arterial, as well as improvements to the I-15 Winchester Road interchange. Phase I of the project included...more
Marketable Record Title Act: right-of-way held by Florida Department of Transportation qualifies for right of way exception under MRTA and remainder of property held in fee by Florida Department...more
The Map Act -- also known as Chapter 136, Article 2E of the General Statutes of North Carolina -- allows the N.C.D.O.T., local governments or other governing bodies to file with the local register of deeds an official...more
Sinkhole/Appraisal: reversing non-final order compelling appraisal of sinkhole claim because one is not appropriate under section 631.54(3)(c), Florida Statutes – Fla. Ins. Guar. Ass'n, Inc. v....more
In the aftermath of last year's Rails-to-Trails Decision, Marvin M. Brandt Revocable Trust v. United States, 572 U.S. ___ (2014), the valuation of rail corridors may become increasingly necessary. Typically there are three...more
As part of our continuing California drone law coverage, today we report on the latest attempt by the California legislature to regulate unmanned aerial vehicles. Introduced yesterday by California State Senator Hannah Beth...more
In This Issue:
- Update on Developments in California Drone Law
- One Community Gets Relief from Aircraft Noise
- California Once Again Relinquishes Clean Air Act Enforcement Responsibility to the...more
In the annual ritual of last minute legislative action, the Senate has passed the renewal of nearly all of the so-called Extenders legislation by a vote of 76 to 16, which will make the tax incentives applicable to calendar...more
The Miami-Dade County Commission adopted Ordinance 14-122, effective December 12, 2014, making several modifications to the County's Road Impact Fee schedule. A notable change is that the timing of the Road Impact Fee Present...more
As traffic continues to increase and roadways become more congested, California's transportation infrastructure needs to keep up. While there has been a concerted focus on alternative methods of transportation (such as rail,...more
We've been quiet these past few weeks but the world has not been. We'd like to talk today about two entirely unrelated but fascinatingly fun topics: (1) the North Carolina Department of Transportation's ("NCDOT") idea to...more
Rental Apartment Construction At 27 Year High. Construction of multifamily units nationally is proceeding at the strongest pace since 1987. Multifamily construction starts have now eclipsed the previous high water mark during...more
September 30, 2014, was the deadline for Governor Jerry Brown to take action on bills passed by the California Legislature during the 2014 regular legislative session. Here are summaries of noteworthy insurance-related bills...more
Earlier this week, on August 25, 2014, the Federal Transit Administration ("FTA") published Circular 7050.1, providing much anticipated guidance for grantees interested in pursuing joint development projects within FTA's...more
Last month, the Supreme Court of the United States (please, there is no such thing as the "United States Supreme Court") decided a very interesting case about easements. "Easements?", you ask. Yes, easements. We use them...more
This week, the Supreme Court ruled that the United States Forest Service could not construct a trail on an abandoned railroad right of way (ROW) that crosses through private property. Brandt v. United States, No. 12-1173,...more
The California High-Speed Rail Authority's (the "Authority") first request to seize a parcel in Fresno County through eminent domain has been approved by the State Public Works Board (the "SPWB"), the state agency that...more
More than 50 years ago, Caltrans purchased roughly 500 homes under threat of eminent domain within the planned right-of-way for the anticipated construction of the I-710 freeway (linking Monterey Park to Pasadena). That...more
In a ruling that benefits public agencies, a state appellate court yesterday overturned a finding of precondemnation liability against the California Department of Transportation. The court held that a causal relationship...more
In a much-anticipated decision filed August 5, 2013, the California Supreme Court held that CEQA requires a lead agency to assess a project's environmental impacts against an "existing conditions" baseline – and consequently...more
On August 5, 2013, the California Supreme Court issued a split decision in Neighbors for Smart Rail v. Exposition Metro Line Construction Authority, et al. The court held that a lead agency may choose to avoid using an...more
In Neighbors for Smart Rail v. Exposition Metro Line Construction Authority (filed August 5, 2013) ("Neighbors"), a majority of the California Supreme Court justices announced a new rule regarding the baseline agencies may...more
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"Barcino / Barcelona" Barcelona by TheaIren
Barcelona Travel Guide: 9,729 reviews and 22,318 photos
Ruins of the Barcino lies below of the Placa del Rei you see in the picture. It dates back to 3rd century BC when Carthagians settled there. City museum gives you oportunity to peek into the ancient times and reviels the ruins of the roman settlement who took over the area around 15 BC.
Of cource Barcelona has a lot of lovely spots and important sights
but it is too crowded to me and too noisy. I mean, there is 1,6 milj. people
living in that city and I'm coming from country where lives 1,5 milj. people. O, and add tourists into this number as well. It means that all these people have put to the one city. I say Wow !
But thing is that in every day what I spent in Barcelona I was so tired in the evening. Therefor I spent 2 days in there and other 4 escaped to nearby citys.
Other con I remember was terrible urine smell on the certain parts of the Ciutat Vella, looks like men have major problem there...But if you don't pay major attention to it ( sometimes it was quite hard )walking in this mase of streets was enjoyable in early mornings.
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Gaudis masterpeace. Yes, it's worth to see ! more travel advice
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Our team of talented attorneys includes a sophisticated group of both transactional and litigation attorneys.  We pride ourselves on successfully blending our legal teams to bring a high level of symbiotic representation to all our clients' complex real estate matters.
We represent prominent entrepreneurial leaders in the real estate industry. Our practice is designed to provide both business acumen and legal expertise to our business leader clients. We also represent major public and private real estate developers, commercial banks, investment banks, hedge funds, and domestic and offshore liquidators, trustees, and individuals to resolve complex commercial disputes, nationally.
We provide practical business solutions in a results oriented manner. With impeccable response time, we simplify complex issues for our clients. We don't waste time and money on unnecessary legal services. We represent our clients through high level negotiations as business partners. We are an innovative practice with an entrepreneurial spirit who offer exceptional guidance in resolving deeply complex real estate transactions and litigation matters.
The New York Times published an article on the Kriss & Feuerstein LLP office renovation.  The new offices were designed by esteemed designer, Andres Escobar, the principal at the Montreal-based Andres Escobar & Associates.  Mr. Escobar used slick elements such as shiny white polyester resin, color-changing lighting, frosted glass, and lacquer finishes in a variety of shades of gray and white to create a modern yet comfortable space.
¬†"We are a young, modern firm just like our clients – the young entrepreneurs in real estate who are constantly designing their own spaces.¬† We wanted something similar to their offices and homes and the restaurants they go to."¬† – David Kriss, Partner at Kriss & Feuerstein LLP
For the full New York Times article click here.


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Playground Safety
- 3532 Dallas High Shoals Hwy, Dallas, NC, 28034
ECERS-R Review
Partnership for Children of Lincoln & Gaston Counties
Thursday, January 17, 2013 from 6:30 PM to 8:00 PM (EST)
The Partnership for Children of Lincoln & Gaston Counties is a nonprofit organization that provides services for local families and children through Smart Start, North Carolina's award-winning early childhood initiative.
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Originally written on Fox Sports Florida | Last updated 7/21/12
While arguably no one's been hotter than Andrew McCutchen of late, the Pittsburgh Pirates' Neil Walker and Pedro Alvarez are also becoming of some well-deserved acclaim. Winner of 14 of 19, Pittsburgh looks to keep things going Saturday night in the second of three games with the visiting Miami Marlins. Sitting one-half game behind Cincinnati in the NL Central, Pittsburgh (52-40) is starting to look more and more like a serious contender. The Pirates have scored a major league-leading 126 runs while batting .302 during a 14-5 run since June 27, with much of the credit understandably going to McCutchen. The All-Star outfielder is batting .451 with 12 homers, 32 RBIS and 34 runs over his last 33 games, though he's hardly solely responsible for Pittsburgh's recent surge. Walker is batting .459 during the last 19 games and Alvarez has hit seven homers to go along with 21 RBIs in his last 17. McCutchen had two hits while Walker and Alvarez both went deep during Friday's 4-3 win. Kevi...
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Part-time archivist Lorelei Galbreath keeps a stack of folders as tall as a newborn on her desk.
1843, from German, name of a rock in the River Rhine near Koblenz, Germany. In legend, a lovely woman sat atop it and sang while combing her long blond hair, distracting sailors so their ships foundered on the rock and they drowned. The second element of the name probably is Rhenish dialect lei "cliff, rock;" the first element is perhaps from Middle High German lüren "to lie in wait"


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Develop your career in a Graduate role that maximises your potential and provides a wealth of opportunities. At Crowe Clark Whitehill, we provide you with diversity in training and client exposure right from the start. Your career path should be tailored for you, we take the time to understand each...
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http://www.nationalfootballpost.com/Don ... ut-me.html
Don't you...forget about me
Ten players who may be overlooked in the draft. Wes Bunting
Bookmark and Share Print This Send This February 13, 2010, 09:08 AM EST
4 Comments
Injuries and character concerns are two major reasons that prospects fall down draft boards at this time of year. Today, the National Football Post takes a look at 10 forgotten players who came into the season with a fair amount of hype but, for one reason or another, failed to meet expectations and now could end up being bargains on draft day.
Michael SmithAPRB Michael Smith
RB Michael Smith, Arkansas (5-7, 180)
Smith has been one of the SEC's most dynamic playmakers the past two seasons and has the skill set needed to create yards in chunks at the next level. However, he struggled to stay on the field during his time at Arkansas because of his lack of size and overall frail frame. But teams needing a potential third-down back with some big-play potential could look Smith's way toward the end of the draft.
TE Jeron Mastrud, Kansas State (6-5, 253)
There isn't anything special about Mastrud's game, but at 6-5 and 253 pounds, he showcased the ability to block in the run game and catch the ball underneath and looked like a solid contributing reserve-type tight end at the next level. However, he struggled with a foot injury for most of the season and now might need to go the free-agent route to earn an NFL roster spot.
WR Mike Williams, Syracuse (6-2, 212)
Simply put, Williams might be the nation's most athletically gifted wide receiver prospect. He's big, physical, can run down the field and is as explosive a leaper as there is in the draft. But after quitting the Syracuse football team this past season, it's anyone's guess how low he could fall.
Eric DeckerAPWR Eric Decker
WR Eric Decker, Minnesota (6-3, 215)
Decker was having a phenomenal 2009 season until a foot injury caused him to miss the final five games. He still finished with 758 receiving yards in eight games, but he most likely will still be unable work out for NFL scouts this draft season. With his speed being his biggest question mark, don't be surprised to see Decker fall a bit farther than most expect come draft day.
DE Auston English, Oklahoma (6-3, 252)
After a productive 9½-sack sophomore campaign, English had several run-ins with the injury bug, causing him to miss stretches of the past two seasons. He's an undersized pass rusher with a good motor but could be a guy who's already starting to wear down from the rigors of the game.
DT Arthur Jones, Syracuse (6-3, 295)
As talented as Jones is, he seems to be getting lost in the shuffle of a very talented defensive tackle class after missing the final three games of the season with a knee injury.
DT DeMarcus Granger, Oklahoma (6-2, 327)
Granger is burdened by the double whammy of character and injury concerns. The size and talent are there, but he's a guy who was never able to put it together during his time at Oklahoma.
Walter ThurmondAPCB Walter Thurmond
CB Walter Thurmond, Oregon (5-11, 182)
To me, Thurmond looked like one of the country's top senior cornerbacks coming into the season based on his junior play. However, he never really had a chance to get going after injuring his knee in September and missing the rest of the '09 season. Even so, I still feel like he could end up contributing to a team at the next level and perhaps starting down the line.
DB Akwasi Owusu-Ansah, Indiana, Pa. (6-1, 205)
A shoulder injury kept Owusu-Ansah from competing vs. the big boys at this year's all-star games, so the small-schools standout is going to need to perform well during his postseason workouts to keep his name fresh in the minds of NFL evaluators.
SS Josh Pinkard, USC (6-1, 215)
You have to feel bad for a kid like Pinkard, who was a team-first player throughout his career at USC. However, after suffering his third major knee injury this season, you have to wonder if this guy is worth any kind of investment at the next level.
10 Overlooked prospects
The year's upcoming draft and the college game can be discussed here.
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10 Overlooked prospects
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