text:
Prostate Cancer Health Center
Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®): Complementary and alternative medicine - Patient Information [NCI] - Introduction
- Introduction
- Overview of CAM Use in Prostate Cancer
- Questions and Answers About Green Tea
- Questions and Answers About Lycopene
- Questions and Answers About Modified Citrus Pectin
- Questions and Answers About Pomegranate
- Questions and Answers About Soy
- Questions and Answers About Zyflamend
- Changes to This Summary (06 / 10 / 2013)
- About This PDQ Summary
- General CAM Information
- Evaluation of CAM Approaches
- Questions to Ask Your Health Care Provider About CAM
- To Learn More About CAM
Men in the United States get prostate cancer more than any other type of cancer except skin cancer. It is found mainly in older men. In the United States, about one out of five men will be diagnosed with prostate cancer. Most men diagnosed with prostate cancer do not die of it.
Complementary and alternative medicine (CAM) is a form of treatment used in addition to (complementary) or instead of (alternative) standard treatments. CAM treatments generally are not considered standard medical approaches. Standard treatments go through a long and careful research process to prove they are safe and effective, but less is known about most types of CAM.
Recommended Related to Prostate Cancer
The prostate is a muscular, walnut-sized gland that surrounds part of the urethra, the tube that transports urine and sperm out of the body. A gland is a group of cells that secretes chemicals that act on or control the activity of other cells or organs. The prostate is part of the male reproductive system. Its main job is to make seminal fluid, the milky substance that transports sperm. Sperm is produced in the testicles, which also make the male hormone testosterone. Testosterone stimulates the...
Read the Prostate Cancer: The Basics article > >
CAM use among prostate cancer patients is reported to be common. CAM treatments used by prostate cancer patients include certain foods, dietary supplements, herbs, vitamins, and minerals.
This PDQ CAM summary gives general information about using foods and dietary supplements to lower the risk of developing prostate cancer or for treating prostate cancer, its symptoms, or side effects of disease treatment. In addition, this summary has sections for six specific foods or dietary supplements:
- Green Tea
- Lycopene
- Modified Citrus Pectin
- Pomegranate
- Soy
- Zyflamend
More topics will be added over time. These sections include the following information for each food or dietary supplement:
- How it is given or consumed.
- Reviews of laboratory and animal studies.
- Results of population studies and clinical trials.
- Side effects or risks.
- Food and Drug Administration (FDA) information.
In this article
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.
WebMD Public Information from the National Cancer Institute


text:
ORLANDO, Fla -- Rashard Lewis and Hedo Turkoglu each scored 22 points to lead the Orlando Magic to a 101-90 victory over the Memphis Grizzlies Wednesday night in the final preseason game for both teams.
J.J. Redick, competing for time at shooting guard, added 15 as the Magic cruised to their sixth straight preseason win.
Reserve Darrell Arthur led Memphis with 18 points. Mike Conley added 13.
Magic star Dwight Howard, who played sparingly in the second half, had 11 points and eight rebounds as Orlando showed signs of being ready to improve on its 52-win, Eastern Conference semifinal performance last season.
Orlando led 53-33 at halftime and scored the first nine points of the second half to blow the game open. Memphis never got closer than 10 the rest of the game.
"We have a special group of guys," Howard said. "Not often you'll find a good group of guys play together like we do. This moment never comes to too many people like this."
Health has been a concern for the Magic, who've had one starter and three subs injured through much of the preseason.
Turkoglu, nursing a groin injury, started and played 34 minutes. He scored six of the Magic's first 11 points and finished with seven rebounds and four assists.
The Magic look to have settled their backcourt puzzle. Mickael Pietrus has earned the starting spot at shooting guard even though his offense has been less than spectacular. During the preseason the free-agent signee from Golden State has averaged less than 10 points a game and shot only 36 percent from the field.
Pietrus sustained a cut over his right eye when he tripped while driving the lane late in the first half. He did not start the third quarter, but entered with just under three minutes left wearing a bandage.
First-round pick Courtney Lee is projected at the backup at both guard spots, but played only three minutes in the first half. Magic coach Stan Van Gundy said during the shootaround Wednesday that Lee would probably get extended minutes.
"He needs them to get comfortable with our system," Van Gundy said.
Lee finished with five points in 15 minutes.
In the offseason Memphis lost its two best long distance threats, Mike Miller and Juan Carlos Navarro. The Grizzlies are counting on rookie O.J. Mayo to replace them, but he was 0-for-2 from 3-point range in the first half. Memphis missed all four of its 3s in the first half.
Mayo struggled early, missing his first six shots.
After making 10 of his first 12 free throws of the preseason, Howard slumped of late, but made seven of 10 against Memphis to move above 60 percent.
Tony Battie was still out of the lineup because of a broken ring finger. He was hurt two weeks ago in practice, but the Magic are hopeful he'll be ready for their regular-season opener Oct. 29 at home against Atlanta. Battie, who missed all of last season after shoulder surgery, has played in only two preseason games and showed flashes of being a strong backup to Rashard Lewis at power forward.
Memphis (4-3)opens Oct. 29 against Houston against Houston.

subset: commoncrawl


text:
Articles tagged georges minois translated by lydia g. cochrane
1 Jan 1995 // 1:03 AM
While it sure isn't beach reading, Georges Minois's 'History of Suicide' isn't nearly as dark nor depressing a book as one might think. Which isn't necessarily a good thing.READ more
//Mixed media
Colette Carr "Static" (video) (Premiere) // Music
House of Blondes "First of July" (audio) (premiere) // Music
Digisaurus 'No More Room For Love' (EP stream) // Music
Eszter Balint 'Airless Midnight' (album stream) (premiere) // Music
//Pm Picks
PopMatters is on a short summer publishing break. We resume Monday, July 6th.
// Announcements
"PopMatters is on a short summer publishing break. We resume Monday, July 6th.READ the article


text:
Related Searches: wolfs head oil sign, oil sign, oil painting signed, signed oil paintings
303 Results for Wolfs Head Oil Sign - For Sale Classifieds
This is an original Wolf's Head Motor Oil Display Sign, found in the back of an Old Speed Shop, from many years ago. Still in great condition! This is a cardboard, standing sign with back for stand, attached. Some1 month ago on ebay.com
This neat glass Paperweight is in good condition and features the Wolf's Head Motor Oil as shown in the picture. The Paperweight measures 3"W X 4 1/4"H X 3/4"D and has a protective felt covered bottom. What a neat item1 month ago on ebay.com
DavidEnnis Store Vintage WOLF'S HEAD Motor Oil VERTICAL SIGN Embossed Metal GAS/OIL Advertising VINTAGE WOLFS HEAD MOTOR OIL VERTICAL METAL SIGN GREAT SHINE Up for sale is a VINTAGE WOLFS HEAD Motor Oil Metal Sign. It1 month ago on ebay.com
WOLF'S HEADMOTOR OIL METAL SIGNPennsylvania CrudeTHIS LIMITED EDITION SIGN MEASURES 5"TALL x 15"WIDE MADE OF ALUMINUM WITH ROUNDED CORNERS AND 4 PRE-PUNCHED HOLES FOR EASY HANGING BUY IT NOW ! SO YOU DON'T FORGET1 month ago on ebay.com
WOLF'S HEAD OIL METAL SIGNMEASURES 5' X 3' AND IS HEAVYDATED 1983NO SHIPPING, LOCAL PICK UP ONLY1 month ago on ebay.com
now make available this quality product for your consideration at a very special price. CRYSTAL STONE WOLF ARROW HEADS!! This tabletop figurine is a beautiful display especially in a sunny spot in your room. Made of mixed1 month ago on ebay.com
I HAVE A OLD WOLF'S HEAD ADVERTISING POSTER. NEVER BEEN DISPLAYED "NEW" THAT READS. TIME FOR A CHANGE, SO CHANGE TO THE BEST. THE FINE PRINT SAYS IT'S WEATHER PROOF FOR INDOOR AND OUTDOOR USE. THE SIGNS LOOK A BIT WAVEY1 month ago on ebay.com
want it, every time. CLICK HERE TO SIGN UP THROUGH eBAY FOR OUR NEWSLETTER as we will be sending discount and promotional codes out to our customers and subscribers throughout 2013. Email newsletters include information on1 month ago on ebay.com


text:
The CP200 CHIRP SideVision™ Sonar expands your underwater horizon with crystal-clear, bank-to-bank displays of fish, bait and underwater structure.
The 14th major quarterly release of Raymarine's LightHouse II software introduces a range of new sail-specific tools and features that are compatible with all Multifunction Display platforms.
Be one of the first to get your hands on the brand new Ocean Scout. Raymarine and FLIR are giving away one of these rugged, compact thermal night vision cameras that let you see other vessels, landmarks, buoys, and floating debris in total darkness.
Go hunting underwater with Raymarine's Pro Ambassador Captain Ray Rosher and Raymarine Sonar Modules.
2015 © FLIR Systems All rights reserved. Privacy Policy|Copyright Policy|Terms of Use


text:
Getty Images
May 18, 2012
A Thai man lays inside a coffin at Wat Prommanee during a rebirth ceremony in Nakhon Nayok,Thailand. The resurrection service follows an hour of prayer lead by Thai monks and then a person stepping into a coffin for a few minutes to arise reborn. Buddhism in Thailand can embrace animist beliefs and magical practices while Thais claim that the true spirit of Buddhism is being lost. The fee for the rebirth service is just 100 Thai bhat ($3 USD). The Thai temple is 66 miles (106 km) northeast of Bangkok.
CTnow.com, 285 Broad St., Hartford, CT 06115
A Hartford Courant website


text:
Mountain Bike : Racing Moto is an new fun addictive game in Android. With this game, you can see a lot of wonderful Mountain Bike : Racing Moto picture. This Mountain Bike : Racing Moto game consist of 3 games: 1) Mountain Bike : Racing Moto memory game 2) Mountain Bike : Racing Moto Puzzle game 3) Mountain Bike : Racing Moto block game
A sequel to the popular PC game Treasures of Montezuma will please fans of puzzles and the match-3 genre. Over 100 levels of ancient Aztec secrets and riddles, plenty of magical artifacts and three game modes - thats what awaits for the players. Playing Treasures of Montezuma 2 youll have to combine pieces of the same color and complete missions within the given time.
Sudoku Free is the no 1 Sudoku game with beautiful graphics and killer features. Sudoku Master has been polished to perfection and boasts an intuitive, touch screen game play which makes you never need a paper puzzle again. Now challenge yourself to more than 2000 puzzles and 4 levels of difficulty from Easy to Expert! Game Features: Two modes, Classic & Casual, 4 Levels, Easy, Normal, Hard, Expert, Smooth interface and Impressive graphics, Auto save & Resume, Undo & Redo function, Smart Notes, Error checking (incorrect entry highlighting), Selected digit highlighting, Statistics tracking Game Rules: Sudoku is a logic based number placement puzzle. The objective is to fill a 9 by 9 grid with digits so that each column, each row, and each of the nine 3 by 3 sub grids contain all of the digits from 1 to 9. Feature: Two modes, Classic & Casual, 4 Levels, Easy, Normal, Hard, Expert, Smooth interface and Impressive graphics, Auto save & Resume, Undo & Redo function, Smart Notes, Error checking (incorrect entry highlighting), Selected digit highlighting, Statistics tracking.
Sudoku is a simple yet highly addictive logic puzzle game. Simply complete the board ensuring that each row, each column and each sub-grid only contains one instance of each piece. At the start of a game a number of pieces are placed on the board. These are known as 'givens'. The remainder of the board contains blank squares for you to complete. You will need to use all your powers of deductive reasoning to solve the unlimited supply of boards that Sudoku can generate. Sudoku supports
A puzzle is a game, problem, or toy that tests a person's ingenuity so be the first to get this awesome Hot Kareena Kapoor puzzle game 2014.A part from being able check out this amazing collection of Kareena Kapoor hot pics,the game will challenge you to reconstruct the pics and test your photographic memory.Enjoy
Bubble Shooter is j2me bubble shoot game . It has many puzzle levels and its a very addictive shoot bubble buster game. Make combinations of 3 or more bubbles to make them burst. Clear all the bubbles to level up. - Easy and fun to play, challenging to master - Cool graphic with color ball like many delicious candy - Easy to relaxing and killing time when walk in park city or waiting bus. How to Play: - Tap where you want to shoot bubble - To group 3 or more bubbles to make them burst -
Legendary classics: now with new stylish design and beautiful animation. After each turn, 3 new balls are placed on a field (random colors in random positions). The player has to arrange balls of the same color in straight lines (in any direction). 5 or more balls on a straight line are removed and points are given. You can move the ball only to the free cell. If movement is not obstructed, the ball will go to the specified empty field. Features: • Fascinating puzzle for all ages; • B
Minecraft Pocket Edition is an new fun addictive game in Android. With this game, you can see a lot of wonderful Minecraft Pocket Edition picture. This Minecraft Pocket Edition game consist of 3 games: 1) Minecraft Pocket Edition Memory game 2) Minecraft Pocket Edition Puzzle game 3) Minecraft Pocket Edition Block game
ninja games online shooting games matching games formula car game simulator games city games police games


text:
Interested in Gengenbach?
We'll send you updates with the latest deals, reviews and articles for Gengenbach each week.
Gengenbach Accommodation
Gengenbach Hotels by Category
| Gengenbach Hotels by Type
| Gengenbach Attractions
| Gengenbach Restaurants
| Gengenbach Restaurants by Type
| Holiday Rentals
| Flights
| TripAdvisor pages
Up one level: Baden-Wurttemberg


text: New stories Upcoming Incoming 40° First look and Japanese date for Glacier White version of Hori's Rock Steady PS4 Vertical Stand 13m ago - The Japanese release date, and first images, have been revealed for the Glacier White version of... | PS4 Comments (0) GamerGaming Source 30° Finalbossgamer- Batman: Arkham Knight Review 48m ago - So this is the final Batman game from the guys over at Rocksteady? If so, it's a fitting ending a... | Xbox One Comments (0) ab1905 Source 8.5/10 finalbossgame... Ad Bulbapedia Now - The community-driven Pokémon encyclopedia. | Promoted post Read More SiteBot 20° Payday 2: Crimewave Edition Review – The Perfect Crime I The Koalition 50m ago - Richard Bailey Jr. of The Koalition writes: Way back in August of 2013, Overkill Software and 5... | PS4 Comments (0) rbailey Source 84/100 thekoalition.com 20° Hitman: Sniper Review – A Silent Killer I The Koalition 50m ago - Richard Bailey Jr of The Koalition writes: Earlier this month, Square Enix released a brand new... | iPhone Comments (0) rbailey Source 76/100 thekoalition.com 20° Final Fantasy 7 HD Remake: Enough With These 3 Questions 1h ago - Idigital Times: I'm still not over the confirmation of a Final Fantasy 7 HD remake at E3 2015. Bu... | PS4 Comments (0) Pozzle Source


text:
User reviews
We haven't found any reviews in the usual places.
No eBook available
Selected Papers from the Bituminous Roads Institute, Conducted by the ...By Bituminous Roads Institute, University of Wisconsin
Get Textbooks on Google Play
Rent and save from the world's largest eBookstore. Read, highlight, and take notes, across web, tablet, and phone.
Go to Google Play Now »


text:
View Singles in Ocean Reef Club
By clicking continue, I agree to receive transactional and promotional emails from Match.com. I understand that I am free to withdraw consent at any time.
By using our site, you agree to the Match.com Terms of Use.
Match.com is the best place to search The Sunshine State for online singles. Start meeting people, winking, emailing, enjoying mutual matches, connections and more! Match.com brings Ocean Reef Club daters together. Make it personal! Don't forget to upload your personal photo to your free, Ocean Reef Club personals ad today.
Carl Fisher, Coconut Grove, Conch Key, Coral Gables, Cutler Bay, Cutler Ridge, Doral, Duck Key, Fisher Island, Flamingo Lodge, Florida City, Goulds, Homestead, Homestead AFB, Islamorada, Kendall, Key Biscayne, Key Colony Beach, Key Largo, Layton, Leisure City, Long Key, Ludlam, Miami, Miami Beach, Miami Springs, Naranja, Olympia Heights, Palmetto Bay, Perrine, Pinecrest, Princeton, Quail Heights, Redland, South Miami, Sweetwater, Tavernier, University of Miami, Virginia Gardens, West Miami view all states »
Asian Men, Black Men, Catholic Men, Christian Men, Divorced Men, Free Online Dating, Gay Singles, Gay Dating, Jewish Men, Lesbian Singles, Single Parents, view all communities »


text:
The Leading eBooks Store Online
for Kindle Fire, Apple, Android, Nook, Kobo, PC, Mac, BlackBerry...
New to eBooks.com?Learn more
- Bestsellers - This Week
- Foreign Language Study
- Pets
- Bestsellers - Last 6 months
- Games
- Philosophy
- Archaeology
- Gardening
- Photography
- Architecture
- Graphic Books
- Poetry
- Art
- Health & Fitness
- Political Science
- Biography & Autobiography
- History
- Psychology & Psychiatry
- Body Mind & Spirit
- House & Home
- Reference
- Business & Economics
- Humor
- Religion
- Children's & Young Adult Fiction
- Juvenile Nonfiction
- Romance
- Computers
- Language Arts & Disciplines
- Science
- Crafts & Hobbies
- Law
- Science Fiction
- Current Events
- Literary Collections
- Self-Help
- Drama
- Literary Criticism
- Sex
- Education
- Literary Fiction
- Social Science
- The Environment
- Mathematics
- Sports & Recreation
- Family & Relationships
- Media
- Study Aids
- Fantasy
- Medical
- Technology
- Fiction
- Music
- Transportation
- Folklore & Mythology
- Nature
- Travel
- Food and Wine
- Performing Arts
- True Crime
- Foreign Language Books
Most popular at the top
The Geometry of Jet BundlesCambridge University Press 1989; US$ 84.00
Provides an introduction to the theory of jet bundles for mathematicians and physicists who wish to study differential equations. more...
Using the Borsuk-Ulam TheoremSpringer 2008; US$ 49.95
A number of important results in combinatorics, discrete geometry, and theoretical computer science have been proved using algebraic topology. While the results are quite famous, their proofs are not so widely understood. They are scattered in research papers or outlined in surveys, and they often use topological notions not commonly known among combinatorialists... more...
Algebraische TopologieSpringer 2005; US$ 39.95
Hauptgegenstand des Buches sind Homologie-, Kohomologietheorien und Mannigfaltigkeiten. In den ersten acht Kapiteln werden Begriffe wie Homologie, CW-Komplexe, Produkte und Poincare Dualitat eingefuhrt und deren Anwendungen diskutiert. In den davon unabha more...
Allgemeine Topologie IDe Gruyter 2007; US$ 49.00
Ideen und Konzepte der "Allgemeinen Topologie" werden anhand einfacher Beispiele vorgestellt und anschlie�end konsequent entwickelt. Alle wesentlichen Begriffe werden anschaulich gewonnen. Der didaktische Aufbau folgt der Idee des "learn & check" - weshalb an allen wichtigen Stellen �bungsaufgaben bereitstehen, f�r die es L�sungsvorschl�ge am jeweiligen... more...
Geometric Aspects of General TopologySpringer 2013; US$ 149.00
This book is designed for graduate students to acquire knowledge of dimension theory, ANR theory (theory of retracts), and related topics. These two theories are connected with various fields in geometric topology and in general topology as well. Hence, for students who wish to research subjects in general and geometric topology, understanding these... more...
An Axiomatic Approach to GeometrySpringer International Publishing 2013; US$ 129.00
Focuses on historical aspects� Supports�contemporary approaches of the three aspects of axiomatic geometry: Euclidean, non-Euclidean and projective Includes full solutions to all famous historical problems of classical geometry and�hundreds of figures more...
Problem PosingTaylor and Francis 2014; US$ 58.95
As a result of the editors' collaborative teaching at Harvard in the late 1960s, they produced a ground-breaking work -- The Art Of Problem Posing -- which related problem posing strategies to the already popular activity of problem solving. It took the concept of problem posing and created strategies for engaging in that activity as a central theme... more...
Elements of Differential TopologyCRC Press 2011; US$ 99.95
Review of Differential Calculus Vector Valued Functions Directional Derivatives and Total Derivative Linearity of the Derivative Inverse and Implicit Function Theorems Lagrange Multiplier Method Differentiability on Subsets of Euclidean Spaces Richness of Smooth Maps Integral Calculus Multivariable Integration Sard?s Theorem Exterior... more...
Games, Puzzles, and ComputationCRC Press 2009; US$ 54.95
"? the games also provide an extremely well-suited platform for the introduction of a unified method for determining complexity using constraint logic ? considers not only mathematically oriented games, but also games that may well be suitable for non-mathematicians ? The book also contains a comprehensive overview of known results on the complexity... more...
Surface TopologyElsevier Science 2001; US$ 89.95
This updated and revised edition of a widely acclaimed and successful text for undergraduates examines topology of recent compact surfaces through the development of simple ideas in plane geometry. Containing over 171 diagrams, the approach allows for a straightforward treatment of its subject area. It is particularly attractive for its wealth of applications... more...


text:
Originally written on Buc Stop | Last updated 11/2/11
TAMPA, FL - SEPTEMBER 14: Safety Sabby Piscitelli #21 of the Tampa Bay Buccaneers warms up for play against the Atlanta Falcons at Raymond James Stadium on September 14, 2008 in Tampa, Florida. The Buccaneers defeated the Falcons 24-9. (Photo by Al Messerschmidt/Getty Images)
Leave a caption comment, win a rare free Bucs gameJust out of curiosity, who can come up with a good caption for this? Sabby Piscitelli, while on the KC Sideline, stares down Cody Grimm, who took his job last year. This was taken from the Preseason KC game.And yes, its a contest. In fact, anyone who leaves a caption will be elegible to receive a copy of the Bucs/Saints game from week 6. The winner will recieve a copy of the 1977 Tampa Bay Buccaneers at New Orleans Saints, the Bucs first ever win in franchise history after going 0-26.Simply leave a comment caption.Ends after the Bucs game, Midnight Sunday.
Comments are closed.
What do you think?To leave a comment, you can:
NFL News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter
|Best of Yardbarker
|NFL News
|MLB News
Today's Best Stuff
For Bloggers
Join the Yardbarker Network for more promotion, traffic, and money.
Company Info
What is Yardbarker?
Yardbarker is the largest network of sports blogs and pro athlete blogs on the web. This site is the hub of the Yardbarker Network, where our editors and algorithms curate the best sports content from our network and beyond.
|© 2015 Yardbarker, Inc. All rights reserved. Use of this website (including any and all parts and components) constitutes your acceptance of these Terms of Use and Privacy Policy. (What's New?)


text:
Galatasaray confirm interest in Maxi PereiraIG: @ERA_GEE101 : Turkish giants Galatasaray have moved to confirm reports linking... http://t.co/rXKCQWcLz0 23 minutes ago ATM Tareq Turkish giants Galatasaray have moved to confirm reports linking them with a summer move for Benfi... NewsR.in, 2 months ago
11 images for maxi pereira
Benfica routs Gil Vicente 5-0 to stay on target for title
Benfica rolled to a 5-0 rout at Gil Vicente on Saturday to stay on track to repeating as Portuguese league champion. Maxi Pereira put the defending champion on its way in the 14th minute, and he added another goal to cap the demolition after ...Miami Herald, 2 months ago Benfica claim their second consecutive Portuguese league title following Porto's failure to beat Belenenses Capital Bay, 1 month ago Benfica strengthened their position as favourites for the title with a 5-0 hammering of Gil Vicente to go six points clear of Porto. FIFA.com, 2 months ago Soccer-Five-star Benfica close in on title Yahoo Philippines News, 2 months ago
Petulant Cavani ends woeful Copa America in fitting fashion
By Jon Arnold at Estadio Nacional In the build-up to Uruguay's quarter-final match against Chile Oscar Tabarez and the Uruguayan fans were concerned that Edinson Cavani might not play Now they'll wish he hadn't The striker received his marching ...Uncova, 1 week ago
Chile 1-0 Uruguay
Goal! Goal! Chile 1, Uruguay 0. Mauricio Isla (Chile) right footed shot from the centre of the box to the bottom right corner. Assisted by Jorge Valdívia. Corner, Chile. Conceded by Maxi Pereira. 78:00 Attempt missed. Cristian Rodríguez ...Social Dashboard, 1 week ago
Claudio Bravo and Chile into semi-finals with hard fought win over Uruguay (1-0)
The Barça keeper captains his side to victory with a striker from Isla in the second half sending the hosts into the last four The 'charrúa' end the game with just nine men after the dismissals of Cavani and Fucile CHILE: Bravo, Isla, Jara, ...Noodls, 1 week ago
Benfica eye Brazilian right-back
Benfica are considering to sign highly-rated Brazilian right-back Mayke, according to media reports. The 22-year-old has impressed the Portuguese club while playing for Cruzeiro, winners of the past two Brazilian Serie A titles, reported Xinhua ...ProKerala.com, 1 week ago Benfica eye move for Brazilian right-back China.org.cn, 1 week ago Benfica eye Brazilian right-back Mayke The Statesman, 1 week ago
Copa America Tactical Preview: Chile - Uruguay
Coincidentally, Uruguay were in a similar situation as underdogs at this stage four years ago, against hosts Argentina, whereas the pressure is on Chile to advance past the first stage of the knockout round the hosts have failed to do so in every ...Digital Journal, 1 week ago Uruguay held but progress to quarter-finals RTE Online, 2 weeks ago Martino's tactics pay off ESPN Soccernet, 2 weeks ago Uruguay 1-0 Jamaica: Cristian Rodriguez's second-half goal gives defending Copa America champions opening group win Capital Bay, 3 weeks ago
Copa America sees rivalries renewed and plenty of drama
Miss any Copa America action this weekend? The Exploding Heads sum up how the group stage ended, including Neymar's red card and a Jamaican selfie with Messi. As the Copa America begins its quarterfinal stage, what strikes you most about this ...ESPN Soccernet, 1 week ago Rivalries restored and lots of drama ESPN FC (blog) NewsListOnline, 1 week ago
Transfer news column: Manchester City eye Chile internationalCharles Aranguiz as Sunderland move forGeorginio Wijnaldum
Manuel Pellegrini watchedCharles Aranguiz during Chile's win over Bolivia Sunderland have made a move for PSV club captainGeorginio Wijnaldum West Ham waiting to hear from Marseille after £9.4m bid for Dimitri Payet Andrea Pirlo still looks likely ...Capital Bay, 1 week ago
Uruguay 1-1 Paraguay: Draw seals quarter-final berth for La Celeste
Uruguay and Paraguay played out a 1-1 draw in Copa America Group B as Oscar Tabarez's men got the point they needed to clinch a place in the quarter-finals of the competition Jose Gimenezpowereda header past a helpless Justo Villar to put the ...Uncova, 2 weeks ago
Realtime News
on your WebpageAdd Widget >Get your members hooked!


text:
"Telling lies is a fault in a boy, an art in a lover, an accomplishment in a bachelor, and second-nature in a married man"
Related quotes
"Art knows no boundaries.... Expressive art; Timeless piece; Artistic representation of feelings without imitations built from creative interpretations; however you want to call it... For us, this is.... Art. "ART ACROSS BOUNDARIES""
"Most of the important things in the world have been accomplished by people who have kept on trying when there seemed to be no hope at all."
"To accomplish great things, we must not only act, but also dream; not only plan, but also believe."
"To be yourself in a world that is constantly trying to make you something else is the greatest accomplishment."
"We are more than what we do . . . much more than what we accomplish . . . far more than what we possess."


text:
One bigass ret-Khan they would need to do...
View Single Post
December 3 2009, 09:27 PM
Rear Admiral
Location: America after the rain
Re: One bigass ret-Khan they would need to do...
Dusty Ayres wrote:
Sabataage wrote:
This negates the fact that if the war was secret nobody would even know Khan existed let alone three hundred years later. He needs to be infamous. In order for Khan to work he must have a lasting and persistent presence in history like Hitler. "Never again!"
When Khan (who was the most famous of them all) seized power in India in the early '90's, he became known for doing so; the others (Randy Morrison, Chen Tijun, Arcturus, etc.) less so since one was a typical right-wing American survivalist with a bunch of like-minded wackos in Florida, another being a group of neo-Amazons on their own island (Chen even wears body armor), and the third-mentioned one is the head of a global space cult similar to the cult that killed themselves in order to go into space by dying (the one that Nichelle Nicols's brother was a member of.) Khan simply had more resources to do what he wanted since he controlled half of India and Asia, and had even built a submarine fleet and a arsenal of missiles. The war itself is seen by historians from the future as being one, but not perceived by the people of the '90's as being a big conflict, rather just seen as part of the conflicts and events of the time, according to (Greg) Cox.
Out of curiosity, how do you even control half of Asia? Each part of Asia hates pretty much all the other parts.
One of these days I might read 'em, but I remain dubious about the concept. Like you said, they sound more like Assignment: Earth novels than Star Trek ones, with crazy pseudo-Bond tropes that have little place in Trek outside of a holodeck episode featuring Julian Bashir. Dr. Noah: Augment?
It doesn't instill much confidence in me that the global danger plot of Moonraker is recapitulated. I mean, I actually loved the movie, but it's the high camp approach to James Bond, which works well there, but I suspect would work horribly in the context of Khan (maybe ironically, since high camp was a staple of TOS). Edit: Mem Beta says that Khan had an ozone laser. Alright. I guess.
Edit: also, I have some moral qualms with the tack apparently taken in the novels. Correct me if I am wrong.
The first I call the "Hitler is an alien" effect.
had a version of this, for example--a relatively innocuous one, but many other works have premised their fiction with aliens either helping Nazi Germany or actually forming the upper echelons of the Nazi Party itself. These stories can be fun, but at their core is the morally offensive concept that the crimes of Nazi Germany were excused because of alien influence, or that humans aren't capable of such evil without outside assistance. At the least, the underlying idea that "wouldn't it be cool if aliens helped kill Jews and Russians?" is a tad disrespectful to Germany's victims. I have kind of the same problem with evil Augments orchestrating real life crimes and tragedies. Yeah, it's fun, but it's still a tad disrespectful. Humanity is perfectly capable of fucking up its own world. Going by Mem Beta here--is southwestern Sudan riven by racial strife wearing the cloak of dangerous religious fundamentalism? Hell, no! Khan did it.
Secondly, and this is something Cox inherited from Space Seed, is the "superior ability breeds superior ambition" conceit, which automatically puts the Augments in the category of villains, or at least megalomaniacs, instead of just people. I've never understood Star Trek's anathema to genetic engineering. In a few years, "Space Seed" will look even more chauvinistic than "Turnabout Intruder." This approach to the Eugenics War isn't very IDIC. Besides, if superior ability breeds superior ambition, why haven't the Vulcans exterminated us by the 24th century? They've had 300 years.
Last edited by Myasishchev; December 3 2009 at
View Public Profile
Send a private message to Myasishchev
Find More Posts by Myasishchev


text:
Ernie Gaines
Song: So Sorry
If you thought it was surprising that Ernie Gaines chose solo jam No over the T.I.-assisted Sip It for his first single this past January, then prepare for an even bigger shock—he's already picked the official... More
Posted 6 years ago
Song: No
Introduced to the Booth via the T.I.-assisted Sip It, R&B singer Ernie Gaines surprisingly selected a different record as his first official single. Most readers are probably thinking, "What does Ernie have in... More
Posted 6 years ago
Featuring: T.I.
Song: Sip It ft. T.I.
If you are a fan of T.I.'s frequent adlibs on other artists' tracks, than you need to check out singer Ernie Gaines' new single, Sip It. Ernie's got his eye on one special lady and plans to get her just a lil'... More
Posted 6 years ago
Sample Text - Sample Link


text:
Win the 'You and Your Dad' Photo Contest and Set Your Dad Up for Summer Grilling
Become a Facebook Fan to Share Our Powerball Winnings
Charles DeRoy Smith Sr. 1928-2013
Elvin L Booth, 1927-2013
Daniel Emery Conrad, 1955-2013
Mary Jane Jackson, 1932-2013
Donald Lee Reese, 1938-2013
Donald Lee Reese, 74, of Casper, Wyoming died February 17, 2013 at the Wyoming Medical Center in Casper, Wyoming after a lengthy illness. A memorial service will be held Friday, February 22, 2013 at 10:00 AM at the First Presbyterian Church of Casper, Wyoming. Pastor


text:
Weaver Pony Breakaway Halter with Adjustable Chin
The Weaver® Pony Breakaway Halter with Adjustable Chin is a great everyday halter, with the added security of a breakaway crown piece in case of emergencies. Made of quality nylon, this halter is adjustable at the chin and comes with a throat snap to ensure the best fit for your horse.
The Weaver® Pony Breakaway Halter with Adjustable Chin measures 3/4" and has a rolled throat design. It features brass plated double crown buckles and a sewn-in solid brass throat snap. Replacement crown straps are available separately.
Customer Reviews
|Write a Review
|This product has not been rated by any customers. Be the first person to write a review of this product.
$75 Monthly Gift Certificate Prize and a $1000 Gift Certificate End of Year Grand Prize
If you own this product, please write a review for it. The Review should be helpful to other Shoppers and reflect your own experience with this product. Prizes awarded based on the quality of the review - positive or otherwise.
Shop all available Weaver Leather products
More For You
$10.95 - $13.95 $14.95
4 Closeouts from $10.95
$15.95 $22.95
7 Closeouts from $15.95
- Company Info
- About Equestrian Collections
- About our Website
- 100% Satisfaction Guarantee
- Customer Testimonials
- eCatalogs
- Home
- Rewards Program
- Join the Mount Up to Rewards Program
- Rewards for You
- Affiliate Program
- Become an Equestrian Collections Affiliate
- Sponsorships & Fundraising
- Terms of Use
- Privacy Policy
- Terms of Use
- Help
- My Account
- Order Tracking
- Returns and Exchanges
- Shipping Info
- Sitemap
- We Care
- Eco-Conscious Products
- No Paper Catalogs - Save Trees
- Customer Service
- Toll Free: (877) 872-4415
- Help Section
- Contact Us


text:
Are You This Merchant? Click Here »
Wish I could give them NO stars. I went in with tires I had purchased and asked if they could install, align and balance my tires they agreed and quoted me...
Cheap, fast and friendly.
Purchased brand new Dunlap tires, all 4, with alignment done at a flat 380 for my Scion. Good price. They got it done quick. Would recommend.
Disclaimer: GiftCards.com Local gift cards are not issued by, sponsored, affiliated or endorsed by the merchant. Are you this merchant? Claim this page.


text:
The Leading eBooks Store Online
for Kindle Fire, Apple, Android, Nook, Kobo, PC, Mac, BlackBerry...
New to eBooks.com?Learn more
- Bestsellers - This Week
- Foreign Language Study
- Pets
- Bestsellers - Last 6 months
- Games
- Philosophy
- Archaeology
- Gardening
- Photography
- Architecture
- Graphic Books
- Poetry
- Art
- Health & Fitness
- Political Science
- Biography & Autobiography
- History
- Psychology & Psychiatry
- Body Mind & Spirit
- House & Home
- Reference
- Business & Economics
- Humor
- Religion
- Children's & Young Adult Fiction
- Juvenile Nonfiction
- Romance
- Computers
- Language Arts & Disciplines
- Science
- Crafts & Hobbies
- Law
- Science Fiction
- Current Events
- Literary Collections
- Self-Help
- Drama
- Literary Criticism
- Sex
- Education
- Literary Fiction
- Social Science
- The Environment
- Mathematics
- Sports & Recreation
- Family & Relationships
- Media
- Study Aids
- Fantasy
- Medical
- Technology
- Fiction
- Music
- Transportation
- Folklore & Mythology
- Nature
- Travel
- Food and Wine
- Performing Arts
- True Crime
- Foreign Language Books
Most popular at the top
FibromyalgiaABC-CLIO 2009; US$ 50.00
A fascinating look at the progression of a once-discounted medical disorder, from suspicion of malingering and mental illness to mainline acceptance by the world medical community. more...
Molecular Mechanisms of SpondyloarthropathiesSpringer 2009; US$ 299.00
It is obvious that over the period an enormous amount of information concerning SpA and HLA-B27 has accumulated, and this has been reflected in the knowledge of molecular mechanism of the spondyloarthropathies. This book aims to synthesize this knowledge and presents the various studies concerning the basic research of SpA. more...
OsteoporosisHarvard Health Publications 2010; US$ 18.00
Each year, osteoporosis contributes to more than 2 million bone fractures in the U.S., with most of these breaks occurring in the hips, spine, and wrist. While many people consider broken bones mere nuisances, the burden of these breaks is often quite heavy. They can steal the ability to perform simple daily tasks, result in pain and deformity, and... more...
FibromyalgiaOxford University Press, USA 2010; US$ 23.99
Characterized by chronic widespread pain, fibromyalgia presents complex problems in both its diagnosis and treatment. Fibromyalgia is a fairly common condition, affecting 2-4% of the population. The condition's prevalence has increased dramatically since 1990. The condition is not new, but has been known by various names, such as fibrositis and... more...
Musculoskeletal MRICRC Press 2008; US$ 419.00
The shoulder girdle The elbow The wrist and hand The hip joint and pelvic girdle The knee The ankle and foot The joints The limbs The spine more...
Common Musculoskeletal ProblemsSpringer New York 2010; US$ 59.99
Extremely accessible writing useful for busy professionals or students Illustrated with photographs and easy-to-understand flow charts more...
C�mo convivir con su artritisBull Publishing Company 2006; US$ 13.95
The only Spanish-language book on arthritis that is current and focused on self-care, this useful guide encourages sufferers to take a proactive approach in controlling their symptoms. Particular care was taken in the translation to accommodate cultural differences and to use standard vocabulary generally understood in most Spanish-speaking communities.... more...
Treat Your Back Without SurgeryHunter House 2011; US$ 17.95
Treat Your Back Without Surgery is based on the acclaimed Texas Back Institute's successful nonsurgical treatments for back injuries. Providing proven exercises and natural healing techniques, this book helps readers diagnose back problems and relieve pain noninvasively. Also included are black-and-white photos, illustrations, back surgery benefits... more...
The Complete Guide to Healing FibromyalgiaSt. Martin's Press 2011; US$ 8.99
� The most comprehensive, up-to-date information available--including the latest preliminary diagnosis guidelines from the American College of Rheumatology � A-to-Z lists of prescription medications, herbal remedies, and natural supplements � Proven strategies for relieving symptoms--muscle pain, stiff joints, fatigue,... more...
Neck and Back ProblemsMainstream Publishing 2011; US$ 9.58
In Neck and Back Problems Jan de Vries deals with many of the most common problems relating to the spine. Drawing on his own vast experience of helping patients overcome their suffering and on various case histories, this book contains practical advice for those millions who endure the agony of backache. Simple exercises and remedies are outlined,... more...


text:
Home Pretty Home ChenOne Home collection targets all those looking for sophistication in both apparel and furnishings under one roof. More... (0)
Ladies, Know Your Rights Inner Wheel Club Karachi Metropolitan has launched a handbook that provides information on rights, laws and support on issues faced by Pakistani women. More... (0)
Classic meets contemporary Copper and Steel's collection offers a refreshing range of contemporary pieces. More... (0)
Another Desi Edition Five million rupees and a cookbook contract is what awaits the very first winner of MasterChef Pakistan. More... (0)
Life After Death The evening centred on the first screening of the Hum TV-produced docudrama, Zindagi, about Pakistan's very first deceased organ donor – Naveed Anwar. More... (0)
And We Have a Winner! The Pakistan Idol journey comes to an end, but what a ride it has been. More... (0)
Celebrating Excellence The 21st Century Business and Economics Club hosted its first get together for Karachi's elite business community earlier in September. More... (0)
The mean streets of Karachi claim yet another victim – activist, humanist, hero, Sabeen Mahmud.
The creme de la creme of the Pakistani entertainment industry turned out to make the Hum Awards a night to remember.
The eagerly awaited and much-hyped Avengers sequel is a serious let down.
This quiet crime drama set in the eighties makes for gripping viewing.
While this is not a terrible movie, It epitomises all that is wrong with literary adaptations today.
Azka Naeem writes about the Pakistan we don't see in the headlines.
A quick look at some of the films which will be playing in local cinemas shortly.
Amrita Sher Gil's self portraits are as haunting and expressive as personal diaries.


text:
Page 1
Cancer and Metastasis Reviews 24: 403–411, 2005.
C ?2005 Springer Science + Business Media, Inc. Manufactured in The Netherlands.
β1 integrin function in vivo: Adhesion, migration and more
C. Brakebusch1and R. F¨ assler2,∗
1Max Planck Institute of Biochemistry, Junior Group "Regulation of Cytoskeletal Organization", Martinsried,
Germany;2Max Planck Institute of Biochemistry, Department of Molecular Medicine, Martinsried, Germany
Key words: integrin, cell adhesion, cell migration, mouse genetics
Adhesion of cells to the surrounding extracellular ma-
trix and to other cells is essential for tissue integrity.
In addition to this structural function, cell adhesion
induces intracellular signaling mechanisms that regu-
late proliferation, apoptosis, cell polarity, differentia-
tion and other processes. Cell attachment is mediated
by specific receptors that can be grouped into various
consisting of an α and a β subunit. 18 different α and 8
differentβ subunitsareknowninmammals,whichcan
combine to 24 different integrin receptors [1,2]. The
integrins which consist of 12 members with different
ligand binding properties. All β1 integrins bind to ex-
tracellular matrix molecules: α1β1, α2β1,α10β1 and
α11β1 are binding to collagen, α1β1,α2β1, α3β1,
α6β1 and α7β1 to laminin, α4β1,α5β1,α8β1 and
αvβ1 to fibronectin, α9β1 to tenascin C and αvβ1 to
interact with cellular receptors: α4β1 and α9β1 bind
to VCAM-1 and α4β1 to MadCAM-1.
If ligands bind to integrin at the extracellular side,
the cytoplasmic integrin tail connnects to the actin cy-
toskeleton and elicits various intracellular signaling
pathways. Since integrin molecules lack an actin bind-
are mediated by integrin associated molecules. Cur-
rently more than 10 molecules are known that bind to
with the intracellular domain of β1 associated α sub-
∗Corresponding author. E-mail: email@example.com
units [3]. At least 4 different proteins, α-actinin, talin,
filamin and integrin linked kinase (ILK) mediate the
attachment to the actin cytoskeleton. These molecules,
however, not only link integrins with the actin cy-
toskeleton, but also function as binding platforms for
producing PIPKIγ. ILK is a serine/threonine kinase
which binds also to β3 integrin [5]. Although mod-
ulation of the kinase activity of ILK by β1 integrin
would be a rather simple way of affecting other sig-
naling cascades, more recent work questioned whether
ILK is indeed functioning in all cells as a kinase. ILK-
deficient fruit flies and worms can be fully rescued by
mutant forms of ILK lacking kinase activity [6,7]. Fur-
thermore, ILK-null fibroblasts and chondrocytes show
normal phosphorylation levels of Akt and GSK3-β,
which were described to be phosphorylated by ILK
[8,9]. Among the integrin associated molecules which
bind to the cytoplasmic β1 tail are furthermore Rack1,
which binds activated PKC, and caveolin, which via
fyn, Shc and Grb2 can affect Erk activation.
By interactions in the extracellular and transmem-
brane domain β1 integrins can furthermore associate
with different membrane proteins such as MMP1,
least nine different tetraspanin receptors [10]. Integrin
ligation can cause signal transduction by the associ-
tion of tyrosine phosphorylation via the EGF receptor
via CD47, uPAR or P2Y receptor [12–14]. Further-
more, lipid rafts might contribute to a concentration of
Page 2
Brakebusch and F¨ assler
integrins and signaling molecules facilitating the for-
mation of supramolecular complexes [15].
The importance of integrin associated proteins for
integrin function was demonstrated by the dominant
main of β1 integrin and the transmembrane and extra-
ably, binding of integrin asssociated molecules to the
available for the endogenous receptors and inhibited
integrin signalling.
This short overview shows that integrin signaling
is complex and dependent on the expression of many
proteins. Furthermore, since there is no integrin spe-
cific signaling mechanism, the relative contribution of
integrins to the activation of for example Erk or FAK
cell lines in vitro to the in vivo function of integrins in
corresponding cell types.
To directly test the importance of β1 integrin func-
sequences of this mutation in different tissues. In the
try to explain the impact of these investigations on our
understanding of integrin function.
membrane (BM), and ectoderm. Mice lacking β1 in-
tegrin die shortly after implantation [17,18]. To under-
stand the molecular reason for this defect we modelled
early embryonic development in vitro by aggregation
of embryonic stem (ES) cells in suspension to embry-
ing factor LIF the cells on the surface of the embryoid
body differentiate into endoderm and form a BM un-
ectodermal differentiation of the cells attached below.
apoptosis leading to a cavity inside the embryoid body.
develop endoderm, but do not form a BM, polarized
ectoderm and a cavity [19,20]. The defective BM for-
mation is caused exlusively by a lack of laminin 1 ex-
pression, since exogenous addition of laminin 1 allows
BM formation also in the absence of β1 integrins [20].
Furthermore, also ectoderm differentiation and cavi-
tation is rescued. The major function of β1 integrin
during early development, therefore, is the induction
of laminin-1 expression. Although many β1 integrins
are binding to BM components β1 integrin is not re-
quired for the formation of a BM. β1 integrin is also
not mediating signals from the BM that induce differ-
entiation and survival of ectodermal cells. Other BM
receptors with redundant functions can fully compen-
the laminin receptor dystroglycan, which alone is not
essential for BM formation, ectoderm differentiation
and cavitation [20,21]. Double knockout of dystrogly-
can and β1 integrin will test whether the expression of
one of these receptors is sufficient for BM dependent
signal transduction during early development.
Which β1-induced signaling pathway is mediating
the regulation of laminin-1 expression in the early em-
bryo? While several mechanisms have been identified
connecting the integrins with the cytoskeleton, the link
to downstream pathways such as Erk, Src, FAK, and
Rho GTPases, which can regulate gene expression is
much less clear. The finding that the protein kinase
be transmitted intracellularly. We therefore generated
tion is dependent on ILK.
Similar to β1 integrin deficient mice, ILK-null mice
die at around implantation [8]. A more detailed analy-
bodies, however, revealed important differences. First,
embryoid bodies made from ILK-null ES cells have a
normal BM. This shows, that ILK is not involved in
the regulation of laminin-1 expression by β1 integrin.
Secondly, β1-deficient embryoid bodies have normal
epiblast polarization and cavity formation in the pres-
ence of exogenous laminin-1 which resuces BM for-
a defective polarization of the epiblast and impaired
cavity formation. This demonstrates that ILK is me-
diating BM-dependent effects independent of β1 inte-
grin. Maybe the impairment of αvβ3 signaling in the
absence of ILK contributes to this phenotype.
Another molecule which could connect the β1 inte-
grin tail to proteins regulating gene expression is talin.
Talin is a big protein with a N-terminal head region
Page 3
β1 integrin function in vivo: Adhesion, migration and more
integrin affinity by inducing a conformational change.
Talin can bind directly and indirectly to the actin cy-
toskeleton, but also to FAK, a soluble tyrosine kinase.
the pathways suggested to activate FAK activity after
integrin ligation. In Drosophila, deletion of the only β
integrin subunit and talin results in similar, though not
identical phenotypes, suggesting a crucial role for talin
in integrin function [22]. In mice, however, 8β integrin
subunits and two talin genes are found. Disruption of
the talin 1 gene results in defective gastrulation due
to impaired mesoderm migration and death at around
E9, significantly later than the lethality of β1-deficient
mice [23]. Whether this relatively "late" phenotype is
associated molecules is not clear.
The phenotype of a mouse mutant in which the C-
terminal sequence of β1 integrin was replaced by 11
ther ILK nor talin are involved in the regulation of
laminin-1 expression by β1 integrin [24]. According
to the mapped binding sites, this β1 mutant should be
unable to bind to ILK, talin or filamin. Mutant mice
have normal BM formation during early embryogen-
esis and die only around day 11. Embryonic fibrob-
lasts established from these mice have severe defects
the induction of laminin-1 expression by β1 integrin.
arated by a BM. The epidermis is made primarily from
keratinocytes and attached to the BM are the so called
basal keratinocytes. They are the only cells in the in-
grins. The attachment to the BM is mediated by α6β4
containing junctions called hemidesmosomes and by
α3β1 and α9β1 integrin. α2β1 is found at the lateral
sides where it might interact with E-cadherin. During
differentiation keratinocytes detach from the BM, be-
come suprabasal cells and finally terminally differenti-
ate to form the dead stratum corneum which provides
a barrier against mechanical and chemical stress.
Hair follicles are skin appendages consisting of an
the basal keratinocyte layer, and several different inner
rootsheath(IRS)andhairshaftlayers. Stemcellsfrom
the bulge region of the hair follicle migrate down the
ORS layer till they reach the hair bulb. There they dif-
later into IRS and hair shaft cells. Stem cells can also
migrate upward towards the interfollicular epidermis
contributing to basal keratinocytes.
To circumvent embryonic lethality mice with a con-
ditional knockout of β1 integrin have been made using
the cre-loxP system. Using a keratinocyte-specific ex-
pression of cre, the loss of the β1 integrin gene was
restricted to the epidermis of the skin. In contrast to
the embryo, β1 integrin is not required for the laminin
expression at the dermal-epidermal junction [25,26].
However, β1 integrins are crucial for the attachment of
basal keratinocytes to the BM, since loss of β1 leads
to widespread blisters between the epidermis and the
BM. Downregulation of α6β4 integrin expression ob-
served in β1-deficient keratinocytes conceivably con-
tributes to the phenotype. Furthermore, β1 integrins
are important for the effective proteolytic processing
absence of β1 integrin, laminin 5 and other BM com-
ponents such as nidogen or collagen IV are aberrantly
deposited in the dermis. Ultrastructurally, the lamina
densa of the BM becomes disrupted and in older mice
is completely missing over large stretches demonstrat-
ing that β1 integrin is crucial for the maintenance of
the BM at the dermal-epidermal junction. Similarly to
skin, β1 integrins are important for the attachment to
and maintenance of the BM in brain [27]. They me-
diate the anchorage of glial endfeet to the meningeal
BM which is impaired in the absence of β1 integrin.
Defects in this BM secondarily lead to defects in the
Cajal-Retzius layer resulting in ectopic accumulation
of Cajal-Retzius cells in the cortical wall.
Loss of β1 integrin in skin decreases the prolifer-
ation of basal keratinocytes by about 70% [25]. In
addition, β1-deficient hair follicles showed a com-
plete loss of transit amplifying cells in the hair
matrix. One explanation for these defects could be
impaired cell cycle progression due to loss of inte-
grin dependent activation of Erk. Another explana-
tion could be reduced Shh signaling. In skin, Shh is
crucial for the growth of the hair placodes [28]. It is
not essential for differentiation into the hair lineage,
deficient skin grafts [29]. Crosstalk of β1 integrin with
Shh was shown for granule cell precursors in brains,
where β1 integrin promotes proliferation and prevents
Page 4
Brakebusch and F¨ assler
differentiation [30,31]. Shh binds to laminin and bind-
ing of the laminin-Shh complex to β1 integrins might
ciently to the patched-smoothenend receptor complex.
Alternatively the crosslinking and simultaneous acti-
vation of integrins and patched-smoothened receptors
results in synergistic effects at the level of intracellular
signaling. As a third way to regulate keratinocyte pro-
liferation, β1 integrin might control the maintenance
of skin stem cells. In neural stem cells β1 integrins
contribute to stem cell maintenance by Erk activation
[32]. Finally, β1 integrins could be important for the
hair follicles to the interfollicular epidermis and to the
hair matrix region. Differentiation of migration defec-
tive skin stem cells before reaching the hair bulb could
be the reason for the deformed hair follicles in mutant
mice which are then removed by phagocytic cells [25].
Severe defects in adhesion and migration of β1-
deficient keratinocytes were observed in vitro as well
ulation of αvβ5 and αvβ6 integrin, β1-deficient ker-
atinocytes were able to migrate and close the wound
following upregulation of αvβ6, β1-null keratinocytes
display aberrant spreading and show an impaired abil-
ity to rapidly reorient their cytoskeleton toward the po-
larized movement [34].
The importance of β1 integrin for cell migration,
however, is tissue specific. During brain development,
neuronal precursor cells proliferate and migrate and
postmitotic neurons have to move along glial fibers to
mice with loss of β1 integrin protein in all neurons and
glia cells at around E12.5 showed a rather normal mi-
was unperturbed (Grauss-Porta et al., 2003).
No increased apoptosis or terminal differentiation
differentiation [25,26].
Chondrocytes are forming the cartilage which is func-
In addition cartilage ensures the longitudinal growth
of long bones. In these bones, chondrocytes of the
so called growth plate sequentially undergo differen-
tiation, proliferation, and maturation to become hy-
pertrophic chondrocytes, which later are replaced by
are arranged in stacks of 6–8 cells parallel to the lon-
gitudinal axis of the bone. Cell division occurs per-
pendicular to the stack and the daughter cells have to
move over each other in order to keep the stack or-
ganization. Chondrocytes express α1β1, α2β1, α5β1,
α6β1, α10β1, αvβ3and αvβ5 integrins which medi-
ate the binding to collagen II, fibronectin, laminin and
vitronectin in the cartilage. Mice lacking the β1 inte-
grin gene in chondrocytes die at birth because of res-
piratory distress [35]. Around 50% of the mutant mice
displayed a cleft palate most likely because of a de-
fective proliferation and migration of chondrocytes in
that region. All newborn mice showed a severe chon-
drodysplasia and the few surviving mice had a pro-
gressive dwarfism. The reason for the chondrodyspla-
sia was found in the growth plate. Chondrocytes of the
proliferative zone were not flattened and did not ar-
range in columns. Apparently, β1-deficient cells of the
proliferative zone are not able to move over each other
β1-deficient chondrocytes showed a decreased pro-
liferation in vivo and in vitro [35]. Several mechanisms
signaling of the Fgfr3 was detected in mutant bones
which negatively regulates chondrocyte proliferation
during endochondral bone formation. Fgfr3 upregu-
lates via Stat1 and Stat5 the expression of cell cycle
in mutant chondrocytes [36]. Secondly, chondrocytes
tion of FAK, a known effector of β1 integrin, while the
levels of Erk were similar in control and mutant mice.
In 6 w old mice, also Erk2 was reduced in the absence
of β1 integrin. Downstream of these pathways, the ex-
pression of cyclin D was diminished and the expres-
sion of p16 and p21 was enhanced, synergizing with
the effects of the increased Fgfr3 signaling. Thirdly,
cytokinesis is impaired in the absence of β1 leading
to an increasing amount of binucleated cells. Since β1
integrin accumulates in the cleavage furrow of chon-
drocytes, it might help to anchor the contracting actin
cytoskeleton to the cell membrane. Finally, Ihh is an
important regulator of chondrocyte differentiation and
proliferation [36]. Perhaps a similar synergism as de-
scribed for Shh and β1 integrin in brain is taking place
Page 5
β1 integrin function in vivo: Adhesion, migration and more
in cartilage. Apoptosis was only slightly increased in
mutant mice.
Generating mice with a chondrocyte-restricted dele-
tion of the ILK gene we tested the involvement of ILK
in β1 integrin dependent functions. Deletion of the
ILK gene restricted to chondrocytes resulted in peri-
natal lethality due to respiratory distress [9,37]. As in
β1-deficient mice, most mutant mice had a cleft palate
suggesting impaired chondrocyte proliferation and mi-
chondrodysplasia corresponded to a decreased prolif-
eration of ILK-deficient chondrocytes, while apopto-
sis was not changed. In contrast to β1-null chondro-
cytes, no defective cytokinesis was observed. ILK-null
chondrocytes in the proliferative zone were slightly
less flattened than control cells and showed an im-
paired stacking. However, both defects were clearly
less pronounced than in chondrocytes lacking β1 inte-
grin. In chondrocytes, therefore, β1 integrin has ILK-
dependent and independent functions.
Hematopoietic system
All hematopoietic cells are derived from hematopoi-
etic stem cells (HSC) which in adult mammals reside
in the bone marrow. Different investigatons suggested
that β1 integrins are crucial for the retention and main-
tenance of HSC within the bone marrow. However, al-
though β1 integrins are essential for homing of HSC
to fetal liver and bone marrow they are dispensable
for adult hematopoiesis [38,39]. β1-deficient HSC are
maintained in the bone marrow indicating that inte-
grin mediated attachment to stromal cells and ECM of
the bone marrow does not contribute to retention, pro-
liferation, survival or the maintenance of an undiffer-
entiated state [40]. Lymphoid, myeloid and erythroid
development proceeds unperturbed in the absence of
β1 integrins. Furthermore, migration of B and T cells
to secondary lymphoid organs was independent of β1
integrin, in contrast to HSC homing. In inflammatory
conditions, however, β1 integrins are likely to play a
cytes, since antibodies against α4 integrin are highly
efficacious in treating Multiple Sclerosis and Morbus
Crohn [41]. Animal experiments suggest, that the anti-
bodies primarily work by inhibition of α4β1 mediated
adhesion of leukocytes to the endothelium of the brain
signaling seems to be important.
Unexpectedly, mice lacking β1 integrin in the
hematopoietic system showed a reduction of the IgM
response after immunization with a T cell dependent
The molecular mechanisms underlying this defect are
still unclear.
In platelets, α2β1 was suspected to be the major
collagen receptor initiating adhesion and clotting dur-
ing wound healing when platelets get in contact with
collagen underlying the disrupted endothelium. Stud-
ies with β1 as well as with α2 deficient mice revealed
that α2β1 integrin is not required for platelet aggrega-
the activation of α2β1 integrin which then strengthens
the thrombus formation without being essential [45].
Also α5β1 or α6β1 contribute to thrombus formation
in vivo, but as α2β1, are not required [46].
During skeletal muscle development, myoblasts de-
rived from the somites migrate long distances through
the embryo before reaching their final location. There
they fuse to form syncytial muscle fibres which are
surrounded by a BM. Intracellularly, they contain a
called sarcomer, which is linked via costameric com-
plexes to the cell membrane.
In vitro, phenotypically normal myotubes can de-
velop from β1-deficient ES cells, although delayed
[47]. Using a conditional knockout system where the
deletion of the β1 integrin gene was induced in myo-
genic precursors, the role of β1 integrin for muscle
formation wasstudied in vivo[48]. Lack ofβ1 integrin
had no apparent effect on the migration and prolifera-
tion of myoblasts. However, it cannot be excluded that
low amounts of β1 integrin protein present in the my-
oblasts prevented phenotypic changes. Since lineage
markers of muscle cells such as Myo-D, α-actinin and
MHCf were expressed also in β1-deficient myoblasts,
the differentiation seems to be unperturbed in the ab-
sence of β1-integrin.
However, clear defects occured at later stages. First,
BM formation around the muscle fibres was severely
impaired, although BM components such as laminin
α2 and collagen IV were produced normally. Second,


text:
great way to get a better workout for my family
good sensory item weight, tactile and fun!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Just as good as the one at my gym
Great to have this at home! Easy to grip, the real deal!
Great product
Great exercise ball. Bought these for my morning bootcamp classes and they are great. The price cant be beat.
Sort Reviews By:
People who bought this also bought


text:
Welcome to Virtual Pet List
Wanting to the biggest Virtual Pet forum on then net? Feel free to sign up today.Sign Up to VPL
Find virtual pet sites, sim games or role playing games to play.
Other websites that we own: virtual pets blog - Admin Forum
New xenforo 1.5 version is coming soon
Favorite type of sub/sandwich
Discussion in 'Health' started by cpvr, Jun 30, 2012.


text:
Design Assistant
Room Galleries
Discover room-by-room inspiration for your home with endless ideas from your favorite brands.
Results for: Room Galleries » Kitchens » Coastal Living » Coastal
Browse by:
More Kitchens
- Eat-in Kitchens(32)
- Galley Kitchens(6)
- Small Kitchens(5)
- Open Kitchens(27)
- Outdoor Kitchens(2)
- Other Kitchens(4)
- Household Basics(33)
- Appliances(7)
- Furniture(9)
- Lighting(8)
- Floors(7)
- Fireplaces and Mantels(1)
- Home Accessories(1)
- Storage(17)
- Small Spaces(2)
Idea Houses
Colors and Patterns
Project Tools
- House PlansExplore our exclusive collection of home plans and blueprints.
- Color AssistantDiscover great new color combos and perfect your palette.
- Project CalculatorsFigure the right amount of paint, tile, flooring, and more.
Cleaned-up Eclectic
From Coastal LivingUpholstered pieces like a periwinkle-tufted chair and a nearly yellow bench have clean, almost modern lines. Vintage bamboo light... » see room
Featured Coastal Galleries:
Top Rated Coastal Pictures
Cottage Chic
Coastal Living5
Just Right
Coastal Living4.5
Most Recent Coastal Pictures
Key West Color
Coastal Living0
Funky Coastal Kitchen
Coastal Living2.5
Open Kitchen and Dining
Coastal Living4
Modern White Kitchen
Coastal Living0
Warm Coastal Kitchen
Coastal Living0
More > Coastal
Room of the Day: A charming kitchen with custom touches perfectly reflects its coastal environment.
Find out the five golden rules for home decorating with interior designer Celia Cleary.
from thisoldhouse.com
Video : How to Waterproof a Basement
Around The Web
More from MyHomeIdeas
Add MyHomeIdeas to:My Yahoo! My Google My MSN My AOL My Netvibes
Most Popular Features
- Instant Makeover
Transform your home with quick, budget-friendly ideas from across our network of sites.
- Same Closet, More Space
- 5 Cheap Craigslist Finds Transformed
- 25 Ways to Create an Outdoor Oasis
- Our 50 Favorite Built-In Storage Ideas


text: Kevork Djansezian/Getty Images [ Local Alcohol Vendors Praised for Checking IDs By Justin Pehrson April 21, 2011 The Casper Police Department would like to extend congratulations to local alcohol vendors who don't sell to underage customers. Read More|Comment Category: Casper News Tags: alcohol sales compliance check, Casper Police Department Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
Sauder HomePlus 23.3" Storage Cabinet
Special Offer:
12 Issues of Sunset Magazine
Included with purchase ($20 value).
Sauder HomePlus 23.3" Storage Cabinet
Weights & Dimensions
|Product Type: Storage cabinet
|Application: Office
|Style: Contemporary
|Primary Material: Wood
|Fire Resistant: No
|Shelves Included: Yes
|Doors Included: Yes
|Drawers Included: No
|Wheels/Casters Included: No
|Country of Manufacture: United States
|CARB Compliant: Yes
|ANSI/BIFMA Compliant: Yes
About the ManufacturerSauder is the world's leading manufacturer of ready-to-assemble furniture that offers solutions for all your furniture needs. They have provided well-crafted and moderately priced home & office computer desks, TV stands and bookcases for more than seven decades. This commitment to quality, design, and personalized customer service has helped make them the fifth-largest furniture manufacturer in the United States and one of the most recognized names in the industry. Discover an entirely new concept in home office furniture, TV stands, bookcases and more at furniture retailers everywhere.
Sauder HomePlus 23.3" Storage Cabinet
Questions & Answers (6)
"Hi, may I know what is the shade of dakota oak?" asked by Mary
"Hi, what is the shade of the Sauder HomePlus 23" Storage Cabinet in Sienna Oak?" asked by Pete
"Hi, what is this cabinet made of?" asked by Seymour
"Hi, does this cabinet include a center divider?" asked by Cary
"Hi, how long are the pull handles?" asked by Jerry
"It says the doors are locking but I don't see a lock. Does it really have a lock?" asked by Rose
Customer Reviews
|5 star
|4 star
|3 star
|2 star
|1 star
Easy to assemble, solid, mostly US made
Beverley from San Jose, CA – Verified Buyer
For ready-to-assemble composite wood furniture, I like Sauder. Their instructions are clear and simple. I was able to assemble this piece by myself, although if you aren't very strong you'd probably need someone to help flip the assembled piece to put on the backing and to stand it up when done assembling it. The furniture is solid and stable. I'm using this in my laundry room, and the quality and look are great for that application. I also like that 90% of their manufacturing is still in the US (per their website). When assembling the cabinet, do follow the instructions that state to hand-tighten all screws. Do NOT use an electric driver or you can easily drive the screws in too far and possibly split the composite wood. The product was well-packaged for shipping. Despite its substantial weight, there was no damage to the product. But you will likely need a very strong person or two people to move the box. It's very heavy.
Storage Cabinet - Versatile
Wep from toronto, ON – Verified Buyer
This cabinet did not disappoint me or my husband when it arrived. It is a good quality product and has reasonably clear instructions to put this together. We were going to have a handyman do it but my husband decided to give it a go instead. We bought 2 of these. He put the first cabinet together [all but the 2 doors] in about 2 hours. It would have taken a lot less time but he doesn't have the proper tools.This was our first experience buying something from Wayfair.com. The are located in the USA but deliver to Canada. It will cost you extra but well worth it. I couldn't find anything here that compared to this. This product is made by Saunder and all parts are excellent and not junk. I would highly recommend this product and Wayfiar.com. Their pre-sales and customer service are excellent. You can also arrange the delivery to suit your schedule.
Worth getting if on a budget and space constrained
Anne from Seattle, WA – Verified Buyer
I bought a new home with no pantry so my two roommates and I needed something quick. This fits perfectly in the only corner of my kitchen that I had room and provides 5 great storage shelves. But a few things to note: The top of the cabinet is NOT finished- it's just a light wood color... you won't see it if you're under 6' like me, but my first tall friend that I had over noticed it (and unfortunately most of my friends are rather tall). You're not supposed to put anything on top of the cabinet as it isn't a weight bearing shelf, but we're using it to hold some lighter items that help to cover up the unfinished wood (cereal boxes, a couple of bags of chips/snacks), and then have a couple extra dark brown placemats underneath that to keep it less noticeable- probably no more than 5 lbs in total weight and it's working just fine. Another thing to note- this thing can be difficult to put together, so like others I would recommend putting it together with someone else. The trickiest part for me was getting the back panel (which is literally just a type of really thick card stock or cardboard) to be nailed into the unit as straight as possible. While the instructions say it has to be laying down to have that back part assembled, we couldn't get it to lie straight so we VERY CAREFULLY stood it up and then were able to get the cabinet straightened out and assembled much more quickly. It's not very sturdy unless you plan to secure it to the wall (which it's supposed to be), or unless you fill up the shelves. I quickly added my pantry items to the unit and found it to be a lot less wobbly once filled. One star removed for the flimsiness of the material and one star removed for the price- would think this is a $150 at most, but I do agree with others that it's good compared to what I could find elsewhere in this color (which I needed to match my kitchen). Would I recommend it? Only to those on a budget and that was space constrained like myself. It's serving it's purpose well and I hope it'll suffice for at least a few years.
Affordable, smart design
Gary from Sunrise, FL – Verified Buyer
Good looking design in a functional, affordable piece of furniture. Straightforward assembly with with a screwdriver and hammer, and only a couple of minor quibbles: 1.) One screw hole on the base was not aligned properly, so it made assembly a little difficult, but only for that piece, and 2.) I was unfamiliar with how to adjust the door hinges, so it took a couple of beats to figure out how to set those correctly, as the instruction manual wasn't particularly clear on those. All told, maybe 2-1/2 hours assembly from start to finish. The hardware pieces even come sorted in their own individually sealed pockets, making access and identification that much easier. Yes, it's particle board with a laminate cover, but a very good value for the price.
Great Product for the price.
Randy from Limestone, Maine 04750 – Verified Buyer
I bought four of these to place on a wall in my kitchen for storage use. They fit great and look great also. Lots of storage room now. The description of the product was very accurate and I love the hinges that come with them. They are easy to put in and are easily adjustable to where you need them. Took about four hours for me to put them together by myself. Used the instruction sheet for the first one and the rest were simple. Great product for a great price. I would recommend them to anybody looking for cheap storage space.
I looks great, arrived in perfect condition and was very easy to assemble
Caroline from Springfield, VA – Verified Buyer
I am 75 years old and anticipated having to have someone else assemble it. I took it out of the box and started reading the directions. They were so clear and all of the parts were very clearly labeled and well as the hardware which were separated in clear plastic wrap pouches. So I decided to give it a go and I did it!!! I just needed another pair of hands to attach the doors. It fits perfectly into a corner in my kitchen and completely solves my storage problem having just downsized from a 4 bedroom house to a 2 bedroom condo with a small kitchen. Also it arrived in perfect condition.
Perfect Pantry for New Townhome
J.M. from Trinity, FL – Verified Buyer
My husband and I just bought our first home and needed to add a large enough pantry for our staples but also extra canned food goods and dog's food. This pantry was the perfect size for our space while giving us amble storage. Pros: I like how the bottom shelf leaves extra space for larger containers. Cons: A little hard and time consuming to put together. Even though we followed the instructions step by step, the doors still don't exactly line up. It's not a major difference (my mom didn't notice when she came to visit until it was pointed out) but we can tell since we use it daily.
Very Sleek and Functional! Great Pantry!
Nancy from Cedar Park, TX – Verified Buyer
We have almost no pantry space, it's a tiny little closet in the kitchen, so this thing has been a real lifesaver. It will hold quite a lot, and accommodates larger items like Costco sized cereal boxes. The shelves adjust at logical intervals, and it comes with just enough shleves. It was easy to put together, and it very lightweight for moving, but still feels sturdy enough. The finish is lovely, and fits perfectly with our other furniture. The only downside is that the handles are slightly uneven. We've tried everything we can think of to get them to be even, but the holes were just not drilled properly. Otherwise it's fantastic.
Sauder HomePlus 23 Storage Cabinet
Karen Redwine from Salina, KS
I really love this cabinet, so much so that I bought another one just like it, My son put it together for me (he hasn't gotten to the second one yet), as it is way too heavy and large for me to manage. It took a little while to figure out how to adjust the brackets, and the doors don't fully meet, but everything does fit squarely. It looks beautiful in my bathroom (I love the dark finish), and I am thrilled with how much it holds. I live in an apartment with only one normal sized closet and a pantry in the kitchen, so that is extremely important to me. There were no problems with the first one, and hopefully the second one will be the same. They are extremely well-packed and both arrived ahead of schedule. Also, with the discount from my first purchase plus the sale price, I saved $70 on the second cabinet.from Wayfair.
Great pantry cupboard
Lucinda from Blandon, PA – Verified Buyer
This was not difficult to assemble but is a two person job because of the bulk. Really am pleased with the sturdiness and the space as I needed more storage in our kitchen area of our mobile home. Pros: Attractive. Easy to assemble. Cons: Need another person to help move pantry during assembly and positioning
OUR SKU # SAU1393HomePlus 23.3" Storage Cabinet is also sometimes listed under the following manufacturer numbers: 411963, 411985


text:
UPDATED: DMX Named Celebrity To Fight George Zimmerman in Boxing Match
For the past two weeks everyone has been going crazy and looking for the sign up sheet to go face to face with George Zimmerman in the boxing ring. Reportedly George Zimmerman wanted to personally fight Kanye West for whatever reason, and Kanye hadn't responded as he shouldn't. Nonetheless, other rappers who have been very vocal about wanting to jump in the ring with Zimmerman is rapper The Game. Recently he called into TMZ and told them that he had contacted celebrity boxing promoter Damon Feldman about jumping in the ring. Feldman responded by saying there were still a few others he had to consider, and it turns out that DMX was picked out of 15,000 applicants. DMX told TMZ:
I am going to beat the living f**k out him … I am breaking every rule in boxing to make sure I f**k him right up
Apparently Zimmerman has been training extremely hard, but we all know DMX's past so he should be able to keep his word. The location and date of the fight will be announced next week at a press conference on February 12th.
What are your thoughts on this boxing match?
Watch New York's Hot 97′s Morning Show phone conversation with promoter Damon Feldman when you continue. . .
Similar Posts:
6 Comments
i signed that petition to stop this- that white man will not make a dime if i have anything to do with it
I really hope this fight don't happen…. The fact that George Zimmerman thinks of himself as a celebrity not to mention he's trying to capitalize off Trayvon Martins name
dmx sit down
DMX is going to beat the shit out of George. i want to see this.
Please quit treating Zimmerman as a celebrity and help shut this nonsense down: http://www.change.org/petitions/damon-feldman-stop-the-george-zimmerman-celebrity-boxing-match?share_id=hIFkvBpZhn&utm_campaign=signature_receipt&utm_medium=email&utm_source=share_petition
This is a damn mess. Why are they bringing more attention to this murderer?


text:
View All
View All
Content Type
View All
Research Activities
General Information
The India Times
November 5, 2013
By: Bruce Riedel
The death of Pakistan Taliban leader Hakimullah Mehsud in a drone attack on November 1 is a dramatic reminder that US President Barack Obama remains determined to use drones to disrupt, dismantle and defeat al-Qaeda and its allies in Pakistan despite all the criticism his policy has generated. It works.
The reaction inside Pakistan is a revealing insight into the struggle under way in the country between those who want to fight terror and those who want to appease it. The US's already dysfunctional relationship with Pakistan has taken another hit as well.
According to one count, the US has used the drones in 378 lethal strikes since 2004. Obama has ordered 327 of them in the four and half years he has been in the Oval Office. According to Pakistan's Defence Ministry, these have killed 2,160 terrorists and only 67 civilians. These have been remarkably effective in putting al-Qaeda in Pakistan on the defensive.
Mehsud worked closely with al-Qaeda in December 2009 to use a Jordanian al-Qaeda triple agent, Humam Khalil al Balawi, to get into a CIA forward operating base on the Afghanistan-Pakistan border. Balawi blew himself up, killing seven CIA officers, two women and five men, as well as a Jordanian intelligence officer. It was one of the worst days in the agency's history. Mehsud appeared sitting with Balawi in a martyrdom video released by the Taliban after the attack.
Mehsud was also involved in a plot to attack Time Square in New York City in May 2010 using a car bomb. A Pakistani American, Faysal Shahzad, was trained by Mehsud and al-Qaeda to build the bomb. Another video was released with Mehsud and Shahzad.
Fortunately, an alert hotdog vendor, a Muslim, spotted the vehicle emitting smoke and alerted the NYPD before it exploded. The NYPD later told me that had it gone off as planned, the results would have been catastrophic.
But most of Mehsud's victims in his violent life were not Americans; by far the majority were his fellow Pakistanis. The Pakistan Taliban has murdered thousands of innocent Pakistanis in the last decade. It has fought a bitter and dangerous war against the Pakistani state and army. Its terror has helped to turn Karachi into a lawless mega city. It tried to murder young Malala Yousafzai and has warned it will kill her if she ever returns to Pakistan. Dozens of other young Pakistani children have been murdered by Mehsud's followers.
His organisation has been hurt by his death but it will not be destroyed by the strike. At best his death will foster infighting within the already fractured group but a new leader will emerge and seek revenge for Mehsud's death. Americans in Pakistan need to be on the alert for retribution. So too should Pakistanis.
The attack is very embarrassing for Pakistan Prime Minister Nawaz Sharif. Last month in Washington, he asked Obama to halt the drone attacks. Sharif has sought to open peace talks with the Taliban. Few expected the peace talks to really bring peace to Pakistan, but now those who wanted to appease the Taliban can blame the Americans for sabotaging any hope of a ceasefire.
But there are also many in Pakistan who know that the Taliban are a deadly threat to the survival of a country where a fragile democracy is struggling to build a stable and prosperous society after years of military dictatorship. It was the Pakistani army and intelligence services that created the jihadist Frankenstein's monster that now torments the country. Zia-ul-Haq is the real grandfather of the Pakistani Taliban because he nurtured the culture of jihadism.
The frequency of lethal drone missions has dropped significantly in the last two years as Obama had tried to calibrate the effectiveness of counter-terror operations against the backlash they create in Pakistan. Even Malala asked him to stop them. But he also knows that they are his only means to disrupt al-Qaeda and Taliban plots to attack American interests from bases inside Pakistan. He knows that he cannot depend on the Pakistani state to curb al-Qaeda.
Next year American and other NATO combat forces will leave Afghanistan. Forward operating bases like the one Balawi blew up will be closed. Whether drone operations will continue past 2014 is an open question today, dependent on whether Kabul and Washington can arrange a bilateral security agreement.
If they can't and the drones are gone, al-Qaeda will regenerate rapidly in Pakistan. Its allies like the Taliban and Lashkar-e-Taiba will help it to rebuild. The ISI will either turn a blind eye or, worse, a helping hand. Americans, Pakistanis and Indians will all be at a greater risk.
Bruce Riedel
Director, The Intelligence Project
Senior Fellow, Foreign Policy, Center for Middle East Policy, Center for 21st Century Security and Intelligence
You have not selected any newsletters.
Blog Post
July 6, 2015,
David Gordon and Thomas Wright
July 6, 2015,
Stephen Watts and Sean Mann
July 6, 2015,
Michael Doran
July 6, 2015,
Senator Chris Murphy
July 6, 2015,
Michael E. O'Hanlon
July 6, 2015,
Jeremy Shapiro
Policy Brief
July 2015,
Carlo Bastasin
July 2, 2015,
Kemal Kirişci and Sinan Ekim
Foreign Policy ›
August 24, 2013,
Bruce Riedel
January 27, 2014,
Bruce Riedel
February 15, 2012,
Michael E. O'Hanlon and Bruce Riedel
January 2, 2011,
Bruce Riedel
December 15, 2014,
Bruce Riedel
August 8, 2011,
Bruce Riedel
October 28, 2013,
Bruce Riedel
May 21, 2015,
Bruce Riedel
The Brookings Institution is a private nonprofit organization devoted to independent research and innovative policy solutions. For nearly 100 years, Brookings has analyzed current and emerging issues and produced new ideas that matter—for the nation and the world.
More ›
1775 Massachusetts Ave, NW,
Washington, DC 20036
© 2015 The Brookings Institution


text:
U.S. Sen. Baldwin on Made in Wisconsin tourUPDATED 8:17 PM CST Jan 16, 2013
Tammy Baldwin makes her first official visit to Milwaukee as a United States senator.
More Video
CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


text:
Out of Stock
© 2015 Replacements, Ltd. All rights reserved.
With Our "Find This For Me" Service we notify you via email once we have stock!
Piece Code: G
Piece Name: Water Goblet
Size: 4 1/4 in
Special Characteristics:
© 2015 Replacements, Ltd. All rights reserved
Piece Code: W
Piece Name: Wine Glass
Special Characteristics:
Piece Code: COLD
Piece Name: Old Fashioned
Size: 3 1/4 in
Special Characteristics:
Piece Code: CHB
Piece Name: Highball Glass
Size: 5 7/8 in
Piece Code: FR
Piece Name: Small Fruit/Dessert Bowl
Size: 4 5/8 in
Piece Code: CRB8
Piece Name: Round Bowl
Size: 8 1/4 in


text:
Bear Archery Goblin Youth Bow Set
Durable composite limbs for the young archer
Able to use for right- and left-handed archers
Two Safetyglass arrows and arrow quiver
Includes finger tab and sight pin
Equipment is ready-to-shoot right away
Barnett Vortex Lite Youth Bow
Draw length adjusts as the shooter improves
Rounded cam delivers softer shooting cycle
Includes three fiberglass arrows
Constructed to ATA/AMO standards
PSE Cody Youth Bow Archery Set, 20 lbs., RH
Ideal for beginning and young archers
Composite riser with fiberglass limbs.
Includes quiver, finger tab, sight, and more
Bear Archery Brave Youth Bow Set
Durable composite limbs and riser
Bow measures 26" axle-to-axle
Includes arrows, armguard, quiver, more
Right-handed only
Bear Archery Kodiak Cub Youth Bow
Classic design originally introduced in 1965
Perfect for young and learning archers
Black-laminated hard rock maple risers
Limbs backed with high-strength fiberglass
Includes a Dacron string
Bear Archery 1st Shot Youth Bow Set, RH/LH, 8 - 12 lbs.
For left or right-handed archers
Recurve bow is 36" axle-to-axle
Includes 2 Safteyglass arrows and belt quiver
Draw weight is 8 - 12 lbs.
Black plastic grip is comfortable
T.R.U. Ball Stinger Youth Bow Release
CNC machined from aircraft aluminum
Folds into sleeve when not in use
Includes cut tube and rod
Built smaller for younger archers
Barnett Vortex Junior Compound Bow
19 - 45 lb. draw weights
Adjustable draw modules
Right Hand Only
Barnett Tomcat Youth Compound Bow Package
Ideal for training new, young archers
Adjustable 60% - 70% let-off
Designed for right-hand use
Package includes sight, arrows, quiver, more
Bear Archery Lil' Brave 2 Youth Composite Bow Set
Specially designed for youth/intermediate shooters
Durable composite limbs and riser
Bear Brave III Bow Set
Suggested for ages 8 and up
Includes a Whisker Biscuit arrow rest
Bow measures 26" from axle to axle
18" to 20" draw length, 15- to 20-lb. draw weight
Includes arrows, armguard, quiver, and pin sight
Quest Radical Compound Bow
Adjusts from youth to adult archer
Forged 6061 aluminum riser
Easy adjustable cam system string system
BCY 452X strings and cables
Patented durafuse finish
Barnett Lil' Banshee Jr. Compound Archery Set
18 lb. draw compound target bow
Perfect for young and learning archers
Ambidextrous reinforced handle
Includes arrows, finger roller, and sight
Barnett Banshee Intermediate Archery Set
Ideal for training new, young archers
Comfortable, soft-touch grip
Ambidextrous reinforced handle
Includes arrows, finger tab, and sight
Tarantula Deluxe Small-Frame Bow Case
Fits old style and new parallel limb bows
Closed-cell foam padding for protection
Two accessory pouches
Arrow pocket
39" x 17"
NXT Generation Youth Rapid Riser Compound Bow
High-performance, fully functional compound bow
3 arrows included - 2 hook-and-loop, 1 suction-cup
Window cling target gives kids something to shoot
Center-fire configuration for left-or-right-handed
Barnett Lil' Sioux JR. Recurve Youth Archery Set
Soft touch grip
Ambidextrous reinforced handle
Includes finger rollers 2 arrows
Pin sight package serves as case
Bear Archery Bullseye X Recurve Bow
Made for the entire family
Take-down design
Multi-laminate limbs for durability
High-quality wood riser
Sight arrow rest mounting holes
Bear Archery Sonoma Recurve Bow
Made for the entire family
Sleek, effective construction
Take-down design
Multi-laminate limbs for durability
Bear Scout Youth Compound Bow Set
Durable composite construction bow
Recommended for children ages 4-7
Intended to build archery skills for sport
For left or right-handed shooters
Includes 2 Safetyglass arrows, quiver, and more!


text: Studio Sessions Colin McGrath: Itinerant Folk Orchestrator WNYC July 30, 2008 The combination of studying the classical tradition and traveling around the world informs the New York songwriter's brand of folk music. He visits WNYC to recount some of his experiences and perform music from his new album, Window Seat. Listen Loading… 17:34 Playlist Embed Embed Close embed modal <iframe src="http://www.npr.org/player/embed/93047831/93040338" width="100%" height="290" frameborder="0" scrolling="no">


text:
dianaflores's review of Cover Girl Perfect Point Plus Eyeliners
399 reviews
60% would repurchase
Package Quality: 3.7
Price: $$
Package Quality: 3.7
Price: $$
on 3/7/2013 8:34:00 PM
Age: 18 & Under
Skin: Acne-prone, Fair, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
This eyeliner is good when first applied, but it dissapears in a couple of hours & you have to reapply it, so I have to carry it around to reapply it. I would prefer something with a longer stay on the waterline & that wouldn't smudge & make you seem like you still have on eyeliner from the night before.
Read all 399 reviews of Perfect Point Plus Eyeliners
Popular Eyeliners
301 Reviews
580 Reviews
317 Reviews
2173 Reviews


text:
Member Since: April 24, 2013
February 5, 2014 at 11:35am
Now the Third Amendment is under attack?
In reply to the story Florida Woman Furious After SWAT Team Orders Her Out of Her Own Home During Standoff With Neighbor and What She Found When She Returned Home
February 5, 2014 at 11:46am
BoilermakerX responded:
February 5, 2014 at 11:49am
Cavallo responded:
February 5, 2014 at 12:11pm
Al Sharptongue responded:
February 5, 2014 at 12:25pm
piemann responded:
February 5, 2014 at 2:30pm
Recce1 responded:
April 24, 2013 at 11:18am
What does 212(a)(3)(B)(i)(II) exactly say?
"a consular officer, the Attorney General, or the Secretary of Homeland Security knows, or has reasonable ground to believe, is engaged in or is likely to engage after entry in any terrorist activity"
In reply to the story 'Armed and Dangerous': Beck's Latest Revelations on Saudi National Once a 'Person of Interest' in Boston Bombings
Thanks for the tip!
Submitting your tip... please wait!
There was a problem submitting your tip.Please try again later.
All information © 2015 TheBlaze Inc


text:
PAWTUCKETŌĆöIt's time to break out the Christmas sweaters and velvet dresses because Santa Claus is coming to town! ŌĆ£Santa to the StarsŌĆØ Brady White is making his annual appearance for Photos with Santa on Saturday, Nov. 23 from 12 p.m. to 2 p.m. at Apex, 100 Main St., Pawtucket.
Paul N. Gingras
PAWTUCKET - Paul N. Gingras, 85, died Wednesday, November 21, 2013 at Home and Hospice Care of Rhode Island. He was the beloved husband of the late Genevieve (Losiewicz) Gingras for 44 years until her death in 2000. Paul was a lifelong resident of the Blackstone Valley; born in Pawtucket the son of the late Joseph and Lena (Baron) Gingras. He was a painting subcontractor until his retirement in 1993.
Lynn M. Simmons
LINCOLN - Simmons, Lynn M (Savastano), 85, formerly of Lincoln Manor, Lincoln, died October 29, 2013 at Charlesgate Nursing Center.
She leaves her son Andrew Acciaioli and his wife Kathleen of Warwick; two sisters, Dorothy Nimmo and Dina Phaneuf and four grandchildren. She was the sister of the late Pearl Romano, Nella D'Agnenica, Blanche Nero and Louis, Leno, Albino and Ernest Savastano.
A private memorial service is planned.
PAWTUCKET ŌĆö The saying goes that you can't look ahead without fully understanding where you've been ŌĆō and why.
Both Cumberland High chief Chris Skurka and St. Raphael Academy mentor Mike Sassi are utilizing that philosophy as they prepare their clubs for a monumental R.I. Division II semifinal, slated for Tucker Field at 7 p.m., Friday.


text:
Thanks for redeeming.{{else}}
Success! Thanks for repurchasing.{{/if}} {{else}} {{#if Expired}}
Increase my visibility!{{else}} {{#if IsMultiPack}}
{{#if HasMultiPack}} You have {{MultiPackCount}} top spot(s) left. Now loading you into the search listings... {{else}} You have used all top spots. Now loading you into the search listings... {{/if}}{{else}}
We are loading you into the search listing pages...{{/if}} {{/if}} {{/if}} {{/if}}
{{Current}} just saw you!{{/if}} {{#if LastTopSpotPurchaseIsMulti }} {{#if HasAnyTopSpot}}
{{#if HasFreeTopSpot }} {{ UnclaimedTopSpotFree }} Free {{/if}} {{#if HasPaidTopSpot }} {{#if HasFreeTopSpot }} & {{/if}} {{ MultiPackCount }} {{/if}} Top Spot{{#if Plural}}s{{/if}} Left{{else}}
0 Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{else}} {{#if HasFreeTopSpot }}
{{ UnclaimedTopSpotFree }} Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{/if}} {{else}} {{#if HasResults}}
{{Current}} see you now!{{else}} {{/if}} {{/if}}
You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
28 year old woman | Denver, CO, USA | Seeking men 27-36
Active within 24 hours
Ms. looking for her Mr.
I am the girl who: -Moved to Denver a year ago, and is looking for an awesome guy -Is passionate about health and fitness....I instruct a ton of cycling classes a week, plus other types of fitness.....hopefully my legs won't fall off :) -An entrepreneur here in Denver.....I can say that I have my dream career of owning my own nutrition consulting business, and helping people live happier, healthier lives. No better feeling then that! -Has a really close knit family -Has a lot of love to give -Is Spontaneous -Will kick your butt in ping pong -Is competitive....don't get me playing Taboo...you'll regret it -Is sarcastic...I'll give it right back to ya -Loves the taste of salty and sweet (guilty pleasure) -Would choose to be physically active most of the time -Is down to earth and easy to get along with -Loves to Explore new places and things -Is not stuck up or materialistic.....friends go to me for advice first -Loves to take her 2 yellow labs into the woods for hikes, but they're not here with me, so I miss this a lot!! Can I adopt your dog?! -Is very playful.....flirtation when there's chemistry is fun -Spends a lot of time with her 2 adorable nephews...Also miss this seeing as they are back in NY.... -Doesn't care what she is doing as long as she is in good company -Loves the beach....Kadeema anyone? -Newly loves country music...I sing it all day long...but don't ask to hear cause it may scare you away -Has lots of stories to tell from a lot of life experience. -Loves to cook.....I can get pretty creative -Is a bit of a health nut -Yes, recently has shorter hair (See photos)....cause why be like every other woman -Will do anything for the ones closest to her -Is 1 of 4 siblings....family get together's are a highlight -Is looking for her partner in crime....only people interested in finding a real relationship please :) -You can bring home to the parents, but also has a wild side Interested? Message me.
Camping , Coffee and conversation , Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Playing sports , Travel/Sightseeing , Watching sports , Wine tasting
Aerobics, Basketball, Bowling, Cycling, Other types of exercise, Walking / Hiking, Weights / Machines
I exercise 5 or more times per week.
I have Dogs
My family has 2 adorable yellow labs, and a sweet little cat.
Middle of the Road
Right now I'd have to say Kauai, Hawaii. I lived there for a month, building homes and teaching children...I have an itch to travel more and explore different parts of the world......would you come with me?
University of Connecticut, Storrs, CT
Being active! Cycling, hiking, people watching, sweet/sour, friends and family, cooking, washing my face at the end of the day, tickling backs, outdoor showers, the beach, arcade bball (champ in the family), seltzer mixed with OJ, ping pong.
Working out, cooking, seeing friends and family, taking spur of the moment weekend trips (would love a partner for this), reading a good book, hiking, researching the latest nutrition news. Suggestions for other fun stuff in the Denver area?
Distant Shores and of course 50 Shades of Grey.....I love to read when time permits.....it's nice to get lost in a good book.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'2" (157cms)
|5'10" (177cms) to 6'5" (195cms)
|Body type:
|Slender, About average, Athletic and toned
|No preference
|Dark brown
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker, Moderately
|Medical / Dental / Veterinary / Fitness
|No preference
I have always been passionate about helping people become live happier and healthier lives. I own my own nutrition consulting business, and can honestly say I have my dream career. I also instruct indoor cycling classes for fun!
|I'll tell you later
|No preference
|Never Married
|Never Married, Divorced
|Have kids:
|Wants kids:
|Definitely, Someday
|White / Caucasian
|No preference
|Spiritual but not religious
|No preference
Jewish but not religious...actually grew up celebrating Christmas as well. My family's holiday celebrations are just an excuse to get together and eat, and have fun!
|Bachelors degree
|Bachelors degree
University of Connecticut where I got a BA in psychology, then went on to study nutrition and fitness.