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We have a web portal about online education degrees and programs.
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text: Gallery: Ward's 10 best engines Audi S4. PHOTO: Bryan Mitchell, Getty Images Volvo S60. PHOTO: Courtesy of Volvo, The Windsor Star Volkswagen Jetta. PHOTO: Courtesy of Volkswagon, The Windsor Star BMW 335is Coupe. PHOTO: Derek McNaughton, Postmedia News Ford Mustang GT. PHOTO: JASON KRYK, The Windsor Star 2010 Hyundai Genesis Coupe. PHOTO: Courtesy of Hyundai, The Windsor Star Mini Cooper S. PHOTO: TYLER BROWNBRIDGE, The Windsor Star Chevrolet Volt electric hybrid vehicle. PHOTO: Ethan Miller, Getty Images By Originally published: December 8, 2010 SMALL MEDIUM LARGE Comments We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. RELATED TAGS Auto NewsNews FROM THE HOMEPAGE News 10 things your car salesman forgot to mention By Brian Turner | July 2, 2015 News Using your car as a taxi? Don't lie about your insurance By Lorraine Sommerfeld | 14 hours ago Entertainment 1940 Plymouth Club Coupe rekindles teenage memories By Greg Williams | July 3, 2015 News Top reasons you'll be pulled over by police this summer By Brian Turner | June 30, 2015 Local Pricing & Incentives Year 20152014 Choose A Make Choose A Model Choose A Trim Please select a vehicle MSRP $--- See what your neighbours are paying GO MORE STORIES Study finds 'robocabs' could dramatically slash emissions BMW says M cars will lose manual transmissions Toll from faulty GM ignition switches rises to 121 deaths Honda says product development needs more time to keep quality Using your car as a taxi? Don't lie about your insurance Refreshed Fiat 500 hatchback unveiled in Europe SHOP FOR USED CARS ON KIJIJI SEARCH NOW

subset: commoncrawl


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Forget about it – Donnie Brasco
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Talk:List of Billboard Hot 100 number-one singles of 1982
From Wikipedia, the free encyclopedia
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I'm sorry, but is there any hint that this is -- obviously -- about the United States? Also, what is the source? What exactly was "issued" on January 2, January 9 etc.? I just don't get it. <KF> 14:10, 1 Apr 2004 (UTC)


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Oscar-nominee Bradley Cooper was the biggest name at the Elle Style Awards
Well there was no denying who the biggest name at the Elle Style Awards was last night, as Oscar-nominee and Silver Linings Playbook actor Bradley Cooper turned up to the UK capital of London last night dressed in a suave looking blue suit with checked tie ensemble (February 11, 2013). However he was far from the only one to turn the heads of the paparazzi as many of the great and good turned out for the annual bash which, far from what it's name would suggest, also awards leading performances in film and television.
Kate Hudson [Left] and Rosamund Pike [Right] were also among the attendees
Hence Cooper's appearance, he was there to pick up a gong for best actor for his role in the aforementioned Silver Linings Playbook. It won't be the biggest award of his career - or perhaps even this month - but they all count as he seeks to build up momentum ahead of the big ones, the Oscars, which take place on February 24.
Daisy Lowe [Left] and Juno Temple [Right] were among the young stars to shine on the red carpet
With most of the other big names from Hollywood opting now to show, it was a night where the young stars could take centre stage on the red carpet. No more keen to do that were Daisy Lowe and Juno Temple. Fashion model Daisy Lowe was brash and breezy with a fifties floral dress, whilst Temple was far more conservative, though still elegant, with her pared down look.
Peaches [Left] and Pixie Geldof [Right] vyed for attention
Other Brits on show were sisters Peaches and Pixie Geldof. The former turned up with her husband Thomas Cohen of the now split-up group S.C.U.M; of the siblings though it was tough to choose between who won the best outfit of the evening, so like the shameless coves that we are, we're going to let you decide for yourselves. What do you think?
Ronnie Wood went for a similar blue to Cooper
Of the men, meanwhile, there was only one other who could compete with Bradley Cooper's star power: The Rolling Stones' Ronnie Wood, still looking sharp aged 65 - though we have to wonder whether he took tips from his younger Hollywood visitor.


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Label: Locz Productions
Manager: Dewayne Loc
Bio: 318 Boyz 4 Lyfe
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"Killin Niggaz World Wide Since I Was Knee High"


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Throughout the late 1960s and 1970s, many old Nazis managed discreetly to trickle back to what they regarded as the fatherland.
From his revolutionary comrades in Cuba, he borrowed the slogan "patria, socialismo o muerte"—fatherland, socialism or death.
For his loyal work on behalf of Putin, Zharov was duly awarded for his "service to the fatherland."


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Destiel kissage by DanglingThpiderWatch
©2013-2015 DanglingThpider
Got bored and wanted to make a thing. So I made the thing
Holy shoots and ladders batman
I love your 'thing'! And all the other 'things' you've done! Brilliant artwork.
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this is srsly amazing. i wish i could do stuff like that when i was boring
bless you
You are really God! AMAZING! This is brilliant art!!!!!!!!!!!!! LOVE this!!!!!! LOVE YOU!!!!!!
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Supernaturally beautiful...
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Oh my dear.. I like it a loooooooootttt


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« July 11 July 13 » Sunday, July 12, 2009
New alternative high school using former fitness location
July 12, 2009 in Idaho Voices on Page I3 Kootenai Bridge Academy, an alternative high school, is occupying the former Precision Fitness Solutions building at 606 River Ave., Coeur d'Alene. The 4,000-square-foot facility originally was the YMCA; the outdoor …
A guiding lighthouse
July 12, 2009 in Idaho Voices on Page I3 Think about all the buildings that have been built. Buildings that can inspire us, that can draw us to them emotionally and physically. Imagine a structure that will create a … 5
Principal gets tough on pranks
July 12, 2009 in Idaho Voices on Page I3 For the past three years, Sandpoint High School Principal Becky Kiebert has received a few gifts from seniors during graduation ceremonies, but they were not gifts of gratitude. Some students …
Music and arts
July 12, 2009 in Idaho Voices on Page I4 Today Charley Packard (Originals) – 6 p.m., Spuds Grill, 102 N. First, Sandpoint, 265-4311
Roger's returns nearly intact, and what a tasty return it is
July 12, 2009 in Idaho Voices on Page I4 "Quick! Grab it before your teacher sees it!" I whispered to the little girl. She was glaring teary-eyed in shock and sadness at her just-dropped chocolate ice cream cone on …
Fourth activities flourish in Bayview even with holiday's Saturday date
July 12, 2009 in Idaho Voices on Page I6 As the morning of theFourth of July dawned, there was much trepidation regarding the potential turnout for Bayview's celebration. This year, unlike others when Bayview picks the Saturday closest to …
July 12, 2009 in Idaho Voices on Page I6 For 07-12-2009
No recovery in sight
July 12, 2009 in Letters There isn't going to be a "recovery." A recovery would mean that the economy would go back to the status quo before the great recession started. Can't happen.
Single-payer means rationing
July 12, 2009 in Letters Ms. Bollinger's letter (July 7) inferring that Rep. Cathy McMorris Rodgers is "misguided" concerning a proposed public health care option lacks a reasonable understanding of this issue and the congresswoman's …
Congresswoman out of touch
July 12, 2009 in Letters Brilliant, just brilliant. Rep. Cathy McMorris Rodgers voted against the American Clean Energy and Security Act, then crowed about it in one of her e-mailed newsletters. Claiming that the bill …
Leash needed on N. Korea
July 12, 2009 in Letters The North Korean ballistic-nuclear test blasts on July 4 triggered international condemnation, most momentously from Korea's historical allies, China and Russia.
Zelaya is the risk
July 12, 2009 in Letters Daily I am reading articles in The Spokesman-Review about a so-called coup in Honduras.
Planning combats blight
July 12, 2009 in Letters Thank you for reporting on the Kootenai County commissioners and the vitally important comprehensive land use plan.
Letters policy
July 12, 2009 in Sports We welcome letters of up to 200 words. All letters are subject to editing. Writers are limited to one letter a month. Please include your signature, street address and telephone …
Just not right
July 12, 2009 in Sports I am very disappointed by all the, "Let's remember Steve McNair's NFL career and not the way he died." pronouncements. Is it really more important to be a gifted athlete …
Country's on wrong path
July 12, 2009 in Letters We save little, we spend ourselves into debt; how do you "spend" yourself out of debt?
Cite Scripture fully
July 12, 2009 in Letters Christy Bristow (Letters, June 27) stated that people hijack the Bible to back up their own opinions. This is true; but how can she write this letter when she is …
Liberals and taxes: no surprise
July 12, 2009 in Letters So, do you think they knew? Do you think the rank and file liberal knew the Obama administration was going to impose new and exciting taxes? Is this a surprise …
Global warming no myth
July 12, 2009 in Letters John Peterson on July 4 (Letters) argued that global warming was a hoax. The counter-evidence is convincing.


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Survival Tips For Black Friday
Black Friday is just about here, and if you're one of the thousands of heavy duty bargain hunters, then you may need some tips for surviving the craziest shopping days of the year. Let's start with Thanksgiving.
Black Friday is just about here, and if you're one of the thousands of heavy duty bargain hunters, then you may need some tips for surviving the craziest shopping days of the year. Let's start with Thanksgiving.
With Black Friday approaching, many people will be heading out to do their holiday shopping. This is the day that most stores give everyone a chance to get more for their money, with some really good sales.
It seems we start the holiday season earlier and earlier every year.
For the first time ever we actually had a little "Coupon Lady" controversy today. When Andrea did her call in, she mentioned that Price Chopper is doing their double gas savings on their gift cards promotion.
Andrea has been busy this week finding the good deals for you , and even helping you figure out how to best pull off the maximum savings on your shopping trip. In today's, pharmacy and department store list she even gives you different scenarios to choose from to find the deal that fits you best
How do you calm your nerves while flying? I don't know about you, but I stare intently at the Skymall Magazine (in the seat pocket in front of you) and tried to make a song out of it. This was actually composed while on a 10 hour flight from Rome to Philadelphia (I need a life really bad!)
Tim McGraw and wife Faith Hill are launching a duet fragrance called Soul2Soul.
This week we are lucky enough to get two shopping lists from Andrea. The deals were just too good to pass up. We will start with the shopping list for Price Chopper. Then I will post a second shopping list for ShopRite. There are a lot of great deals to take advantage of and she even posts some websites you can go to to print your coupons out from home.
This week there are a ton of great deals to be found. Maybe not as much "free" stuff but you really can save a bundle on groceries and gas. In Andrea's printable shopping list she will show you some great deals on things like Pepsi, Halloween candy, and one of my personal favorites, Hatfield pork loins. She will also show you how to save an extra 20 cents on gas with Price Chopper while you stock up on Clorox cleaning supplies.
Well, according to Andrea, "The Coupon Lady", there are some great deals today and tomorrow at "Price Chopper". As we do every week I am giving you the link to thgis weeks "shopping list". She has put it in a printable file for you to just use and add whatever you want to shop for
Time to make that grocery list and save some serious dough. Our resident "coupon lady", has furnished her weekly printable grocery list for you with all the good deals and room for you to write in your own. Personally, I am jazzed about the Rice Crispy Treats.
As I mentioned in an earlier story, it's almost back to school time. The time of year that puts a smile on every child's face. Well, maybe not.


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friendly staff, very close to train and bus station, nice to stay for 2 or 3 days.
- Official Description (provided by the hotel):
- Located opposite Marrakech Train Station, the Ryad Mogador Opera is near the Royal Theatre. This hotel has outdoor swimming pools and a spa with a heated indoor pool, sauna and a traditional Hammam. Ryad's air-conditioned rooms are equipped with satellite TV and a private bathroom. Free Wi-Fi in the public areas and free parking are available. Ryad Mogador Opera has 2 restaurants, Le Bahia and Le Badii, that serve traditional Moroccan and international cuisine. Guests can also relax in Ryad's tea room. Services on offer include meeting facilities, hairdressing salon, baby-sitting, currency exchange and car rental. The hotel is easily accessible from the Marrakech Menara Airport. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, Travelocity, HotelTravel.com, Odigeo, Hotels.com, Priceline and HostelBookers so you can book your Ryad Mogador Opera Hotel reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Ryad Mogador Opera Marrakech


text: D. Michael McIntyre wrote: > On Tuesday 28 April 2009, Thomas Chef wrote: > >> connection with my Yamaha MM6, which is connected with USB. It always >> happens shortly or directly after I move any of the controls on the synth, >> like the bend or cutoff / resonance knobs ? > > Unfortunately, I can't think of any suggestions for this one. If I could come > over to your house and piddle around, I might think of something, but short > of that I'm at a total loss for ideas. Perhaps Thomas could record the MIDI stream coming from the MM6, and someone who knows what MIDI events and such are could look at it and see if maybe some synth controller is sending an event that causes a problem? -- David gnome@... authenticity, honesty, community


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Linn Akurate Exakt/Akudorik
This system makes a formidable argument for Linn's Exakt philosophy. Rarely have we come across such a neat, compact and talented system0%Our rating
McIntosh MXA70
A large dose of McIntosh in a compact package. This is a deeply desirable system, even if the price is mighty steep0%Our rating
Linn Majik DSM
The Majik DSM is a thoughtfully designed system that's a pleasure to use0%Our rating
Lyngdorf Digital 2.2 System (hi-fi)
It might have some flaws, but this Lyngdorf system is something different from the norm, and well worth a look0%Our rating
Meridian G95
It's not cheap, but it's stylish, usable and hugely capable0%Our rating
Naim N-Vi
Naim is a high priest at the church of stereo purism and the N-Vi deserves to be worshipped0%Our rating
B&O Beosound 9000
Great if you're looking for an ostentatious system that'll attract 'oohs' and 'aahs' from friends, even if it's not a class-leading sound or value pro0%Our rating
All-in-one systems reviews & products
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Embassy of Canada to Tunisia
Services for Canadians
Information for Canadians travelling or living abroad. Tips on travel documents, travel health, returning to Canada and more.
Visas and Immigration
Information and forms for visiting, working or living in Canada.
Find out the steps and the information you need to provide.
Embassy of Canada
Rue de la Feuille d'Erable
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Tunis, Tunisia
Contact and office information >>
Ambassador's Message >>
2015-06-01 - Human Rights Reporting: Training for Journalists in Maghreb
2015-05-22 - Graffiti sets the backdrop for tomorrow's Tunisia
2015-03-18 - Minister Nicholson Strongly Condemns Terrorist Attack in Tunisia
2015-01-09 - Recruiting In-Demand, Skilled Immigrants to Canada; Express Entry will contribute to Canada's economic growth and international competitiveness
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The Buzz: Business news
Business, media, technology and more in the Capital Region and beyond
Posts filtered on Category
Malta Hannaford opens this weekend
Hannaford Supermarkets will open its new store at 43 Round Lake Road in Malta on Saturday with a two-day ce lebration featuring gift card giveaways and other prizes. The store opens at 7 a.m. Hannaford also will open a store in Columbia County the same day. The Malta store will be open 24 hours a day, […] [Read More]
Whole Foods taking space in Colonie Center Sears
Whole Foods will lease 32,000 square feet of space on the first floor of the two-story Sears store at Colonie Center, opening its first upstate market in the spring of 2014, Whole Foods spokesman Michael Sinatra said Thursday morning. The store will be "our first venture outside of Westchester County," he added. Sears spokesman Chris […] [Read More]
Price Chopper supermarkets raise $348,000 for MDA
Price Chopper Supermarket customers throughout the state supported the retailer in its Shamrocks Against Dystrophy fundraising program, helping it raise $348,787 for local individuals living with neuromuscular diseases. Locally, the Mechanicville supermarket raised more than $11,000. Customers were asked by store associates to buy a Shamrock for $1 or $5. MDA recognized Mechanicville Price Chopper's […] [Read More]
What supermarket would you like to see here next?
We have Price Chopper and Hannaford, Trader Joe's will be here this summer, and ShopRite today opened its second Capital Region store. That leaves Wegmans and Whole Foods, as well as such chains as Stop and Shop and Big Y. [Read More]
Price Chopper expands its online shopping service
Seven months after introducing its Shops4U online purchasing and delivery service in Niskayuna, Price Chopper has expanded it to its Westgate store at 911 Central Ave. in Albany. For a fee of $10, the service, available to residents of certain zip codes surrounding the store, provides in-store pickup of your online order or, for an […] [Read More]
Trader Joe's near the top of latest Consumer Reports rankings
Wegmans tops the list of favorite supermarkets ranked by readers of Consumer Reports, with a score of 88 on a scale of 100. Trader Joe's, which will open its first Capital Region store later this spring, came in second, with a score of 86, topping third-pace Publix at 85. Neither Wegmans nor Publix has stores […] [Read More]
Jane and Neil Golub receive philanthropy award at Chicago Home Show
Jane and Neil Golub received the Lifetime Philanthropy Award at the 15th annual Housewares Charity Foundation Gala, held in conjunction with the International Home + Housewares Show in Chicago. Jane Golub, Price Chopper's director of in-store marketing programs; and Neil Golub, executive chairman of the board, are the only supermarket executives to ever be honored […] [Read More]
Wegmans: We succeed because we put employees first
That's the thrust of an article on Atlantic.com, which describes the western New York supermarket company's slow (it opens just three stores a year) but steady growth. Wegmans also benefits from larger than average stores and intensive training, sending employees off to farms, ranches and other suppliers to learn about what they sell. The company […] [Read More]
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Are you G Zupi?Claim your profile
Publications (183)807.72 Total impact
- SourceAvailable from: Daniela Passeri
Article: DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents[Show abstract] [Hide abstract]
ABSTRACT: We previously reported that the G-quadruplex (G4) ligand RHPS4 potentiates the antitumor activity of camptothecins both in vitro and in tumor xenografts. The present study aims at investigating the mechanisms involved in this specific drug interaction. Combination index test was used to evaluate the interaction between G4 ligands and standard or novel Topo I inhibitors. Chromatin immunoprecipitation was performed to study the presence at telomeres of various types of topisomerase, while immunolabeling experiments were performed to measure the activation of DNA damage both in vitro and in tumor xenografts. We report that integration of the Topo I inhibitor SN-38, but not the Topo II poison doxorubicin with telomere-based therapy is strongly effective and the sequence of drug administration is critical in determining the synergistic interaction, impairing the cell ability to recover from drug-induced cytotoxicity. The synergistic effect of this combination was also observed by using novel camptothecins and, more interestingly, mice treated with ST1481/RHPS4 combination showed an inhibition and delay of tumor growth as well as an increased survival. The study of the mechanism(s) revealed that treatment with G4 ligands increased Topo I at the telomeres and the functional relevance of this observation was directly assessed by showing that standard and novel camptothecins stabilized DNA damage both in vitro and in xenografts. Our results demonstrate an outstanding efficacy of Topo I inhibitors/G4 ligands combination, which likely reflects an enhanced and persistent activation of DNA damage response as a critical determinant of the therapeutic improvement.Clinical Cancer Research 02/2011; 17(8):2227-36. DOI:10.1158/1078-0432.CCR-10-3033
Article: PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy[Show abstract] [Hide abstract]
ABSTRACT: New anti-telomere strategies represent important goals for the development of selective cancer therapies. In this study, we reported that uncapped telomeres, resulting from pharmacological stabilization of quadruplex DNA by RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate), trigger specific recruitment and activation of poly-adenosine diphosphate (ADP) ribose polymerase I (PARP1) at the telomeres, forming several ADP-ribose polymers that co-localize with the telomeric repeat binding factor 1 protein and are inhibited by selective PARP(s) inhibitors or PARP1-specific small interfering RNAs. The knockdown of PARP1 prevents repairing of RHPS4-induced telomere DNA breaks, leading to increases in chromosome abnormalities and eventually to the inhibition of tumor cell growth both in vitro and in xenografts. More interestingly, the integration of a TOPO1 inhibitor on the combination treatment proved to have a high therapeutic efficacy ensuing a complete regression of the tumor as well as a significant increase in overall survival and cure of mice even when treatments started at a very late stage of tumor growth. Overall, this work reveals the unexplored link between the PARP1 and G-quadruplex ligands and demonstrates the excellent efficacy of a multi-component strategy based on the use of PARP inhibitors in telomere-based therapy.Oncogene 11/2010; 29(47):6280-93. DOI:10.1038/onc.2010.344
Article: In vitro and in vivo antitumor efficacy of docetaxel and sorafenib combination in human pancreatic cancer cells.[Show abstract] [Hide abstract]
ABSTRACT: The response of pancreatic cancer to treatments remains unsatisfactory, highlighting the need for more effective therapeutic regimens. Sorafenib, an orally available multikinase inhibitor, is active against different tumors, including pancreatic cancer. We studied the antitumor efficacy of sorafenib in combination with different antitumor drugs currently used in clinical practice in in vitro and in vivo experimental models of human pancreatic cancer. The cytotoxic effect of sorafenib and conventional antitumor drug combinations was evaluated in vitro in human pancreatic cancer cell lines and the efficacy of the most active combination was tested on tumor-bearing mice. Flow cytometric, Western blot and immunohistochemistry analyses were performed to investigate the mechanisms involved in the activity of single drugs and in their interaction when used in combination. Sorafenib showed a strong sequence-dependent synergistic interaction in vitro with docetaxel, which was highly dependent on the drug sequence employed. In vivo, human pancreatic cancer-xenografted mice treated with docetaxel followed by sorafenib reduced and delayed tumor growth, with complete tumor regression observed in half of the mice. This marked antitumor effect resulted in an overall increase in mouse survival of about 70% and in a complete cure in 3 of the 8 treated mice. The strong activity was also accompanied by marked apoptosis induction, inhibition of tumor angiogenesis and downregulation of ERK signalling. Our results show that the docetaxel and sorafenib combination exerts high therapeutic efficacy in experimental models of human pancreatic cancer, indicating a promising antitumor strategy for clinical use.Current cancer drug targets 09/2010; 10(6):600-10.
Article: In Vitro and In Vivo Antitumor Efficacy of Docetaxel and Sorafenib Combination in Human Pancreatic Cancer Cells[Show abstract] [Hide abstract]
ABSTRACT: The response of pancreatic cancer to treatments remains unsatisfactory, highlighting the need for more effective therapeutic regimens. Sorafenib, an orally available multikinase inhibitor, is active against different tumors, including pancreatic cancer. We studied the antitumor efficacy of sorafenib in combination with different antitumor drugs currently used in clinical practice in in vitro and in vivo experimental models of human pancreatic cancer. The cytotoxic effect of sorafenib and conventional antitumor drug combinations was evaluated in vitro in human pancreatic cancer cell lines and the efficacy of the most active combination was tested on tumor-bearing mice. Flow cytometric, Western blot and immunohistochemistry analyses were performed to investigate the mechanisms involved in the activity of single drugs and in their interaction when used in combination. Sorafenib showed a strong sequence-dependent synergistic interaction in vitro with docetaxel, which was highly dependent on the drug sequence employed. In vivo, human pancreatic cancer-xenografted mice treated with docetaxel followed by sorafenib reduced and delayed tumor growth, with complete tumor regression observed in half of the mice. This marked antitumor effect resulted in an overall increase in mouse survival of about 70% and in a complete cure in 3 of the 8 treated mice. The strong activity was also accompanied by marked apoptosis induction, inhibition of tumor angiogenesis and downregulation of ERK signalling. Our results show that the docetaxel and sorafenib combination exerts high therapeutic efficacy in experimental models of human pancreatic cancer, indicating a promising antitumor strategy for clinical use.Current Cancer Drug Targets 08/2010; 10(6):600-610. DOI:10.2174/156800910791859489
Article: Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90[Show abstract] [Hide abstract]
ABSTRACT: Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is a critical mediator of the cellular response to hypoxia. Enhanced levels of HIF-1alpha, the oxygen-regulated subunit of HIF-1, is often associated with increased tumour angiogenesis, metastasis, therapeutic resistance and poor prognosis. It is in this context that we previously demonstrated that under hypoxia, bcl-2 protein promotes HIF-1/Vascular Endothelial Growth Factor (VEGF)-mediated tumour angiogenesis. By using human melanoma cell lines and their stable or transient derivative bcl-2 overexpressing cells, the current study identified HIF-1alpha protein stabilization as a key regulator for the induction of HIF-1 by bcl-2 under hypoxia. We also demonstrated that bcl-2-induced accumulation of HIF-1alpha protein during hypoxia was not due to an increased gene transcription or protein synthesis. In fact, it was related to a modulation of HIF-1alpha protein expression at a post-translational level, indeed its degradation rate was faster in the control lines than in bcl-2 transfectants. The bcl-2-induced HIF-1alpha stabilization in response to low oxygen tension conditions was achieved through the impairment of ubiquitin-dependent HIF-1alpha degradation involving the molecular chaperone HSP90, but it was not dependent on the prolyl hydroxylation of HIF-1alpha protein. We also showed that bcl-2, HIF-1alpha and HSP90 proteins form a tri-complex that may contribute to enhancing the stability of the HIF-1alpha protein in bcl-2 overexpressing clones under hypoxic conditions. Finally, by using genetic and pharmacological approaches we proved that HSP90 is involved in bcl-2-dependent stabilization of HIF-1alpha protein during hypoxia, and in particular the isoform HSP90beta is the main player in this phenomenon. We identified the stabilization of HIF-1alpha protein as a mechanism through which bcl-2 induces the activation of HIF-1 in hypoxic tumour cells involving the beta isoform of molecular chaperone HSP90.PLoS ONE 06/2010; 5(7):e11772. DOI:10.1371/journal.pone.0011772
- EJC Supplements 06/2010; 8(5):104-104. DOI:10.1016/S1359-6349(10)71207-6
Article: Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line[Show abstract] [Hide abstract]
ABSTRACT: The capability of PARP activity inhibitors to prevent DNA damage recovery suggested the use of these drugs as chemo- and radio-sensitisers for cancer therapy. Our research, carried out on cultured human M14 melanoma cells, was aimed to examine if PJ-34, a potent PARP activity inhibitor of second generation, was per se able to affect the viability of these cancer cells without any DNA damaging agents. Using time-lapse videomicroscopy, we evidenced that 10 microM PJ-34 treatment induced severe mitotic defects leading to dramatic reduction of cell proliferation and to cell death. PJ-34 cytotoxic effect was further confirmed by analysis of cell viability and clonogenic assay. Absence of canonic apoptosis markers allowed us to exclude this kind of cell death. No single and/or double stranded DNA damage was evidenced. Immunofluorescence analysis showed an aberrant mitotic scenario in several cells and subsequent multinucleation suggesting an atypical way for cells to die: the mitotic catastrophe. The detection of aberrant accumulation of polymerised actin inside the nucleolus was noteworthy. Taken together, our results demonstrate that, targeting PARP activity by PJ-34, cancer cell survival is affected independently of DNA damage repair. Two findings are remarkable: (a) cisplatin concentration can be reduced by three quarters if it is followed by treatment with 10 microM PJ-34 for 24 h to obtain the same cytotoxic effect; (b) effects dependent on PJ-34 treatment are reversible. Our data suggest that, to reduce the harm done to non-tumour cells during chemotherapy with cisplatin, the latter could be coupled with PJ-34 treatment.Journal of Cellular Physiology 02/2010; 222(2):401-10. DOI:10.1002/jcp.21964
Article: Abstract C170: Inhibition of poly(ADP-ribose) polymerase (PARP) increases the therapeutic efficacy of the G-quadruplex ligand RHPS4/irinotecan combination in cancer xenograftsMolecular Cancer Therapeutics 12/2009; 8(Supplement 1):C170-C170. DOI:10.1158/1535-7163.TARG-09-C170
Article: Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models.[Show abstract] [Hide abstract]
ABSTRACT: Despite the low efficacy of conventional antitumour drugs, chemotherapy remains an essential tool in controlling advanced gastric and oesophageal cancers. We aimed to provide a biological rationale based on the sorafenib-taxotere interaction for the clinical treatment of gastric cancer. In vitro experiments were performed on four human gastric cancer cell lines (GK2, AKG, KKP and NCI-N87). Cytotoxicity was evaluated by sulforhodamine B (SRB) assay, cell cycle perturbations, apoptosis and mitotic catastrophe were assessed by flow cytometric and microscopic analyses, and protein expression was studied by Western blot. In the in vivo experiments, nude mice xenografted with the most resistant line were treated with sorafenib and docetaxel singly or in association. Sorafenib inhibited cell growth (IG(50) values ranged from 3.4 to 8.1 μM) and caused down-regulation of MAP-K/ERK phosphorylation and of mcl-1 and p-bad expression after a 48-hr exposure. Apoptosis induction was associated with caspase-3 and -9 activation and mitochondrial membrane depolarization. The drug combination enhanced apoptosis (up to 80%) and produced a synergistic interaction when low doses of the taxane preceded administration of the antityrosine kinase. This synergism was probably due to the induction of an anomalous multidiploid G0-G1 peak and to consequent mitotic catastrophe, which increased sensitivity to sorafenib. Consistent with in vitro results, the docetaxel-sorafenib sequence exhibited high therapeutic efficacy in NCI-N87 mouse xenografts producing tumour weight inhibition (> 65%), tumour growth delay (up to 25 days) and increased mouse survival (30%). Our findings suggest the potential clinical usefulness of treatment with sorafenib and docetaxel for advanced gastric cancer.Journal of Cellular and Molecular Medicine 12/2009; 15(2):316-26. DOI:10.1111/j.1582-4934.2009.00993.x
Article: Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression.[Show abstract] [Hide abstract]
ABSTRACT: We examined the autocrine/paracrine role of interleukin-8 (CXCL8) and the functional significance of CXCL8 receptors, CXCR1 and CXCR2, in human malignant melanoma proliferation, migration, invasion and angiogenesis. We found that a panel of seven cell lines, even though at different extent, secreted CXCL8 protein, and expressed CXCR1 and CXCR2 independently from the CXCL8 expression, but depending on the oxygen level. In fact, hypoxic exposure increases the expression of CXCR1 and CXCR2. The cell proliferation of both M20 and A375SM lines, expressing similar levels of both CXCR1 and CXCR2 but secreting low and high amounts of CXCL8, respectively, was significantly enhanced by CXCL8 exposure and reduced by CXCL8, CXCR1 and CXCR2 neutralising antibodies, indicating the autocrine/paracrine role of CXCL8 in melanoma cell proliferation. Moreover, an increased invasion and migration in response to CXCL8 was observed in several cell lines, and a further enhancement evidenced under hypoxic conditions. A CXCL8-dependent in vivo vessel formation, evaluated through a matrigel assay, was also demonstrated. Furthermore, when neutralising antibodies against CXCR1 or CXCR2 were used, only the involvement of CXCR2, but not CXCR1 was observed on cell migration and invasion, while both receptors played a role in angiogenesis. In summary, our data demonstrate that CXCL8 induces cell proliferation and angiogenesis through both receptors and that CXCR2 plays an important role in regulating the CXCL8-mediated invasive and migratory behaviour of human melanoma cells. Thus, blocking the CXCL8 signalling axis promises an improvement for the therapy of cancer and, in particular, of metastatic melanoma.European journal of cancer (Oxford, England: 1990) 09/2009; 45(14):2618-27. DOI:10.1016/j.ejca.2009.07.007
Article: Growth-Inhibitory and Antiangiogenic Activity of the MEK Inhibitor PD0325901 in Malignant Melanoma with or without BRAF Mutations 1 2[Show abstract] [Hide abstract]
ABSTRACT: The Raf/MEK/ERK pathway is an important mediator of tumor cell proliferation and angiogenesis. Here, we investigated the growth-inhibitory and antiangiogenic properties of PD0325901, a novel MEK inhibitor, in human melanoma cells. PD0325901 effects were determined in a panel of melanoma cell lines with different genetic aberrations. PD0325901 markedly inhibited ERK phosphorylation and growth of both BRAF mutant and wild-type melanoma cell lines, with IC(50) in the nanomolar range even in the least responsive models. Growth inhibition was observed both in vitro and in vivo in xenograft models, regardless of BRAF mutation status, and was due to G(1)-phase cell cycle arrest and subsequent induction of apoptosis. Cell cycle (cyclin D1, c-Myc, and p27(KIP1)) and apoptosis (Bcl-2 and survivin) regulators were modulated by PD0325901 at the protein level. Gene expression profiling revealed profound modulation of several genes involved in the negative control of MAPK signaling and melanoma cell differentiation, suggesting alternative, potentially relevant mechanisms of action. Finally, PD0325901 inhibited the production of the proangiogenic factors vascular endothelial growth factor and interleukin 8 at a transcriptional level. In conclusion, PD0325901 exerts potent growth-inhibitory, proapoptotic, and antiangiogenic activity in melanoma lines, regardless of their BRAF mutation status. Deeper understanding of the molecular mechanisms of action of MEK inhibitors will likely translate into more effective treatment strategies for patients experiencing malignant melanoma.Neoplasia (New York, N.Y.) 09/2009; 11(8):720-31. DOI:10.1593/neo.09398
Article: Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway[Show abstract] [Hide abstract]
ABSTRACT: Functional telomeres are required to maintain the replicative ability of cancer cells and represent putative targets for G-quadruplex (G4) ligands. Here, we show that the pentacyclic acridinium salt RHPS4, one of the most effective and selective G4 ligands, triggers damages in cells traversing S phase by interfering with telomere replication. Indeed, we found that RHPS4 markedly reduced BrdU incorporation at telomeres and altered the dynamic association of the telomeric proteins TRF1, TRF2 and POT1, leading to chromosome aberrations such as telomere fusions and telomere doublets. Analysis of the molecular damage pathway revealed that RHPS4 induced an ATR-dependent ATM signaling that plays a functional role in the cellular response to RHPS4 treatment. We propose that RHPS4, by stabilizing G4 DNA at telomeres, impairs fork progression and/or telomere processing resulting in telomere dysfunction and activation of a replication stress response pathway. The detailed understanding of the molecular mode of action of this class of compounds makes them attractive tools to understand telomere biology and provides the basis for a rational use of G4 ligands for the therapy of cancer.Nucleic Acids Research 08/2009; 37(16):5353-64. DOI:10.1093/nar/gkp582
Article: G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors[Show abstract] [Hide abstract]
ABSTRACT: The formation of G-quadruplex structures at telomeric DNA sequences blocks telomerase activity, offering an original strategy to design and develop new antitumor agents. The pentacyclic acridinium salt RHPS4 is one of the most effective and selective G4 ligands able to rapidly disrupt telomere architecture, resulting in apoptosis of cancer cells. Here, we studied the therapeutic index of RHPS4 and its integration with chemotherapeutics in preclinical model of solid tumors. The antitumoral activity of RHPS4 was evaluated on human xenografts of different histotypes and compared with that of standard antineoplastic agents. Moreover, the effect of RHPS4/chemotherapeutics combinations on cell survival was studied and the most favorable combination was evaluated on tumor-bearing mice. RHPS4 was active in vivo as single agent and showed a high therapeutic efficacy when compared with conventional drugs. Moreover, RHPS4 had antitumoral activity in human melanoma xenografts inherently resistant to chemotherapy and exhibited antimetastatic activity. RHPS4 also showed a strong synergistic interaction with camptothecins and this effect was strictly dependent on the drug sequence employed. Treatment of mice with irinotecan followed by RHPS4 was able to inhibit and delay tumor growth and to increase mice survival. Our data show that RHPS4 has a good pharmacodynamic profile and in combination therapy produces a strong antitumoral activity, identifying this drug as promising agent for clinical development.Clinical Cancer Research 12/2008; 14(22):7284-91. DOI:10.1158/1078-0432.CCR-08-0941
Article: Involvement of nuclear factor-kappa B in bcl-xL-induced interleukin 8 expression in glioblastoma.[Show abstract] [Hide abstract]
ABSTRACT: We recently reported that bcl-xL regulates interleukin 8 (CXCL8) protein expression and promoter activity in glioblastoma cells. In this paper we demonstrate that CXCL8 induction by bcl-xL is mediated through a nuclear factor-kappa B (NF-kB)-dependent mechanism. Mutational studies on the CXCL8 promoter showed that NF-kB binding site was required for bcl-xL-induced promoter activity and an enhanced nuclear expression of NF-kB subunits p65 and p50 was observed after bcl-xL over-expression. Electrophoretic mobility shift assay showed an increased DNA-binding activity of NF-kB in bcl-xL over-expressing cells and the use of specific antibodies confirmed the involvement of p65 and p50 in NF-kB activity on CXCL8 promoter sequence. NF-kB activity regulation by bcl-xL involved IkBalpha and IKK complex signaling pathway. In fact, bcl-xL over-expression induced a decrease of cytoplasmic expression of the IkBalpha protein, paralleled by an increase in the phosphorylation of the same IkBalpha and IKKalpha/beta. Moreover, the down-regulation of the ectopic or endogenous bcl-xL expression through RNA interference confirmed the ability of bcl-xL to modulate NF-kB pathway, and the transient expression of a degradation-resistant form of the cytoplasmic NF-kB inhibitor IkBalpha in bcl-xL transfectants confirmed the involvement of that inhibitor in bcl-xL-induced CXCL8 expression and promoter activity. In conclusion, our results demonstrate the role of NF-kB as the mediator of bcl-xL-induced CXCL8 up-regulation in glioblastoma cells.Journal of Neurochemistry 10/2008; 107(3):871-82. DOI:10.1111/j.1471-4159.2008.05661.x
- EJC Supplements 10/2008; 6(12):17-17. DOI:10.1016/S1359-6349(08)71976-1
Article: 62 POSTER Expression and functional activity of interleukin-8 receptors on human malignant melanoma cellsEJC Supplements 10/2008; 6(12):22-22. DOI:10.1016/S1359-6349(08)71994-3
Article: The G-quadruplex ligand RHPS4 interferes with telomere replication leading to ATR-dependent DNA damage responseEJC Supplements 07/2008; 6(9):87-88. DOI:10.1016/S1359-6349(08)71514-3
- [Show abstract] [Hide abstract]
ABSTRACT: Our previous data have shown that in L929 mouse fibroblasts the control of methylation pattern depends in part on poly(ADP-ribosyl)ation and that ADP-ribose polymers (PARs), both present on poly(ADP-ribosyl)ated PARP-1 and/or protein-free, have an inhibitory effect on Dnmt1 activity. Here we show that transient ectopic overexpression of CCCTC-binding factor (CTCF) induces PAR accumulation, PARP-1, and CTCF poly(ADP-ribosyl)ation in the same mouse fibroblasts. The persistence in time of a high PAR level affects the DNA methylation machinery; the DNA methyltransferase activity is inhibited with consequences for the methylation state of genome, which becomes diffusely hypomethylated affecting centromeric minor satellite and B1 DNA repeats. In vitro data show that CTCF is able to activate PARP-1 automodification even in the absence of nicked DNA. Our new finding that CTCF is able per se to activate PARP-1 automodification in vitro is of great interest as so far a burst of poly(ADP-ribosyl)ated PARP-1 has generally been found following introduction of DNA strand breaks. CTCF is unable to inhibit DNMT1 activity, whereas poly(ADP-ribosyl)ated PARP-1 plays this inhibitory role. These data suggest that CTCF is involved in the cross-talk between poly(ADP-ribosyl)ation and DNA methylation and underscore the importance of a rapid reversal of PARP activity, as DNA methylation pattern is responsible for an important epigenetic code.Journal of Biological Chemistry 07/2008; 283(32):21873-80. DOI:10.1074/jbc.M801170200
- European Urology Supplements 03/2008; 7(3):278-278. DOI:10.1016/S1569-9056(08)60827-1
- [Show abstract] [Hide abstract]
ABSTRACT: Functional telomeres are required for the replicability of cancer cells. The G-rich strand of telomeric DNA can fold into a 4-stranded structure known as the G-quadruplex (G4), whose stabilization alters telomere function limiting cancer cell growth. Therefore, the G4 ligand RHPS4 may possess antitumor activity. Here, we show that RHPS4 triggers a rapid and potent DNA damage response at telomeres in human transformed fibroblasts and melanoma cells, characterized by the formation of several telomeric foci containing phosphorylated DNA damage response factors gamma-H2AX, RAD17, and 53BP1. This was dependent on DNA repair enzyme ATR, correlated with delocalization of the protective telomeric DNA-binding protein POT1, and was antagonized by overexpression of POT1 or TRF2. In mice, RHPS4 exerted its antitumor effect on xenografts of human tumor cells of different histotype by telomere injury and tumor cell apoptosis. Tumor inhibition was accompanied by a strong DNA damage response, and tumors overexpressing POT1 or TRF2 were resistant to RHPS4 treatment. These data provide evidence that RHPS4 is a telomere damage inducer and that telomere disruption selectively triggered in malignant cells results in a high therapeutic index in mice. They also define a functional link between telomere damage and antitumor activity and reveal the key role of telomere-protective factors TRF2 and POT1 in response to this anti-telomere strategy.Journal of Clinical Investigation 12/2007; 117(11):3236-47. DOI:10.1172/JCI32461
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Mayor should offer voice
Published: Monday, October 12, 2009 at 5:40 p.m.
Last Modified: Monday, October 12, 2009 at 5:40 p.m.
Editor: Citizens of Thomasville, lend me your voice. Over the past years I have seen your voice dwindled down to two minutes with no questions in the council meetings. You have the right to voice your opinion, and the elected leaders have the obligation to hear your opinions and concerns. Even an accused felon has the right to question his/her accusers. As the accused felon has his/her attorney for their voice, you the citizens have your mayor for your voice.
Do you feel your mayor is giving you a voice? When I am elected your mayor, you will have a voice, I guarantee it. I will hold those famous town hall meetings where you can voice your concerns and ask questions. You deserve that respect; after all, the council is supposed to work for you not against you. The city manager works for the city council, which should guide the city manager in all matters, not the other way around.
Does this seem strange? It is strange - in the old ward system the council member had to honor their constituents or be ousted. In the current system, the council member really doesn't have to listen to anyone because they can recruit a different group to stay in office. Now with no one to hold accountable, you have no voice as a whole, and the non-voting mayor has the obligation to be your voice of reason. This election vote Terry Hill for your voice as mayor on the city council.
Remember to vote no on the extend terms. It doesn't cost that much to run for office in Thomasville. You should be able to vote a council person or a mayor out of office every two years if they are not providing the citizens with good business practices.
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text: Magazine Published in June 2012 Sticker Shock By Corie Russell | June 2012 Participant education needed before 404(a)(5) deadline If retirement plan participants are not educated about 404(a)(5), they may be surprised by their first quarterly statement under the new regulation, later this year. Employee Retirement Income Security Act (ERISA) 404(a)(5) requires plan sponsors to provide fee information to participants by August 30. Jim Sampson, managing principal at Cornerstone Retirement Advisors LLC, says plan sponsors could face strong reactions from participants if they are uninformed about 404(a)(5) and its purpose.Plan advisers should schedule educational meetings with participants and sponsors alike before the 404(a)(5) compliance deadline, he says. Participants must be made aware that the fees they see in their quarterly statements have always existed but were merely invisible until now. The adviser should communicate that the inclusion of these fees in statements is a positive change for participants and plan sponsors. Sampson suggests explaining the benefits of fee disclosure this way: "When is the last time you bought something and had no idea what it cost? We do it every week in our 401(k) plan." Plan advisers should also schedule a meeting with participants to teach them how to read their quarterly statements, he says.


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GHS music students bring home honors from Grand Island
Gothenburg High School choral and band students returned from Grand Island Thursday with high ratings.
Students participated in district music contest at Grand Island Senior High.
A vocal group consisting of Chris Block, Joshua Clark, Sonie Kuhlman, Elisa Meridith and Janae Wiggins, who sang "Be Still My Soul," was selected as an outstanding performance at the contest.
Rachel Rice received a superior rating for her flute solo.
Other results are as follows:
Find the complete story and individual results in our print edition. Receive the entire issue of the Gothenburg Times on-line in PDF format each Wednesday for only $25 per year. Call 308-537-3636 to subscribe.
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Castle Star Seamus Dever Loves the L.A. Subway
It's been a month since Stana Katic (Beckett) and Seamus Dever (Detective Kevin Ryan) introduced us to a little something called "The Alternative Travel Project" — a Sierra Club initiative that encourages people to find other means of travel (besides hopping in their gas-guzzling SUVs).
The two Castle actors decided to participate by vowing to take an alternate form of transit one day per week, be it bus, train or helicopter (kidding, obvi). And although the duo admitted early on that it was definitely a challenge, Dever has now publicly come out with his love for the L.A. public transit system, particularly — gasp! — the subway. He also says he has also been quite a fan of biking everywhere he can, regardless of L.A.'s lack of bike lanes.
Alright, so if he's so in love, what's stopping Dever from giving up his car completely? The long hours on the Castle set, he says. "My wife prefers me not to bike at home at 3 in the morning — although I don't mind. I'm kind of tired at that time, when it gets really late," he says. "I'm not really worried about people drinking and driving and hitting me on my bike. But at the request of my wife, I drive those days of the week." Aww!
But Dever does admit it isn't always safe to be out on a bike in certain parts of the city. Dever was actually hit by a driver this past summer, and has since learned not to take biking lightly. "You have to be ultra alert. It's not one of those things like you're in your car and you can sort of zone out and make your way," he says. "You have to watch the road underneath you and you have to be probably twice as resourceful of a driver than the people driving cars when you're on your bike."
As far as the other cast members, Dever says he's still working on them (particularly Nathan Fillion, who lives in The Valley on the outskirts of the city — making public transit quite the hassle). Regardless, he's still an advocate. "A lot of people aren't aware that you can do a combination of things. It doesn't have to be just bus, or just subway, or just biking. I think that's why people's perceptions are, 'Oh, it's too difficult, I have to transfer five spots.' But all it requires is a little more planning," he says.
A little more planning to save a lot more gas? We think that's quite the noble gesture!
Source: Scpr.org


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The following articles were printed from New Times [newtimesslo.com] - Volume 28, Issue 34
Art v. Craft: Spring Arts Annual
While Art lounges in a fainting couch, twirling its monocle and sucking down a dry martini, Craft bumbles its way through Applebee's wearing culottes and a fanny pack. Art only watches documentaries and foreign films. Craft is a big Will Ferrell fan. That's what some people would have you believe, anyway. The truth about the distinction between Art and Craft is a great deal more complicated, definitely less cliché, and entirely subjective anyway. Arts Editor Erin Messer makes her spring arts debut by exploring the relationship between art and craft, with a little help in the form of extensive calendar listings from Calendar Editor Trever Dias, who also makes his spring arts debut.
—Ashley Schwellenbach, managing editor
Keep it brief: 28th annual 55 Fiction Record algal bloom producing neurotoxin that affects ocean shellfish Political Watch 7/2/15 Community Notebook 7/2/15 - 7/9/15 Clinically underserved: Guadalupe is slowly losing medical services Oil bills engendered by Refugio spill pass out of committee Bull shot by CHP officer after getting loose on Hwy. 101 near Buellton


text: I am an artist who works in semi rural NSW. I have horses, cats, dogs, chooks, wild birds, kangaroos, possums, a garden, vegie garden,grandchildren, children, and my husband who all impact on my art. I work in photography, textiles, and on canvas… and often crossing all mediums to make sure that the artwork speaks for itself.


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Book Search
New Regional Geopolitics in the Indo-Pacific
Drivers, Dynamics and Consequences
Series: Routledge Contemporary Asia Series
This book explores the emergence of the Indo-Pacific concept in different national settings. Chapters engage with critical theories of international relations, regionalism and geopolitics in reflecting on the emergence of this new regional construction. They explore the domestic drivers and foreign...
To Be Published January 31st 2016 by Routledge
Indian Foreign Policy
The Politics of Postcolonial Identity from 1947 to 2004
Series: Interventions
The rise of India as a major power has generated new interest in understanding the drivers of its foreign policy. This book argues that analysing India's foreign and security policies as representational practices which produce India's identity as a postcolonial nation-state helps to illuminate the...
Published September 12th 2014 by Routledge


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At BVE 2012 this month, Sonifex will show its new Redbox RB-VHDDD8 Dolby E and Dolby Digital decoder and de-embedder. The unit de-embeds 16 channels of audio within any audio group of an SDI video signal and a further two, which are sent to the Dolby decoder. Up to 10 channels from the decoder or any of the 16 channels from the de-embedder can then be re-embedded onto either of the two SDI outputs and also transmitted on a BNC or D-type situated on the rear panel.
The company also will highlight its new Redbox RB-VHEDD8 Dolby E encoder and embedder. The united encodes eight channels of audio into two channels of an AES/EBU digital audio stream, which is then embedded onto any of the available groups within each of the two video output paths. The encoded Dolby E bit stream is also available via a dedicated output on the rear panel. The audio inputs to the encoder can be selected to come from the external digital audio inputs or from embedded audio contained in the incoming SDI input. The outputs from the de-embedder can also be re-embedded into the video outputs, along with the encoded inputs.
An Inside Look at Four Virtual Reality Start-Ups
What Moves the Social TV Needle?
Mark Kudsi Directs 'Art of Patron Virtual Reality Experience'
BT Renews Intelsat Deal
Top Twitter TV Shows for 2014-15 Season Unveiled
comScore Introduces MobiLens Plus
North Korean Propoganda Art Inspires the Credits of 'The Interview'
Imaginary Forces Creates Kaleidoscopic Titles for 'Bosch'
Filmmaker Embraces Short Documentary Format with Oscar-Nominated 'Crisis Hotline'
North Metro Television Goes Wireless with Comrex LiveShot
Spectra Logic and HauteSpot Networks Introduce Body-Worn Camera Video Surveillance Solution
Huge Ultra HD Display Lights Up Times Square


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With the Samsung Galaxy S Aviator, US Cellular gains another Android smartphone option. Unfortunately, the carrier's limited 4G LTE access and the weak single-core CPU weigh down an otherwise high-flying handset.
The style-savvy Skullcandy Roc Nation Aviator headphones earn our recommendation for balancing a unique thematic design with exceptional clarity in spite of a slightly passive low-end response.
By landing safely in Hawaii after a five-day leg, the Swiss plane -- on an around-the-world trip -- also sets the record for longest solo flight by time.
It was called a day that would live in infamy: December 7, 1941. Today Pearl is a busy harbor for US Navy and civilian traffic, and home to some incredible museums.
The custom launcher and home screen app for Android adds new features and is now available for all users.
The Solar Impulse 2, which is entirely powered by solar energy, is attempting to fly from Nagoya, Japan, to Hawaii. The flight will take approximately five days.
For CNET's Dan Terdiman, it's a dream come true: "flying" underwater in the $1.7 million DeepFlight SuperFalcon.
Technically Incorrect: During a performance, the pop star attempts to grab a drone that is flying around to get crowd shots. It didn't quite go as planned.
During Marissa Mayer's tenure as CEO, Yahoo has acquired many companies. But Mayer singled out the artificial intelligence service Aviate for its potential to help the company make big ad bucks on mobile.
Of the almost 40 companies Marissa Mayer acquired since taking over Yahoo in 2012, artificial intelligence service Aviate — and not Tumblr — may turn out to be the biggest catch.


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Barry Monush, author of The Sound of Music FAQ: All That's Left to Know About Maria, the von Trapps, and Our Favorite Things talks with Patrick Phillips of "Pop Culture Tonight" about his new book!
The Sound of Music FAQ is a comprehensive, encyclopedia-like reference to the world's most popular movie musical. Rather than focusing on the often-told stories of this classic movie, this book looks at the 1965 Oscar-winner in relation to its source, including the true von Trapp family story and the Broadway musical from which it was derived.
The Sound of Music FAQ explores such facts and trivia as the movie's phenomenal original run in cinemas, during which it dominated the box office for a staggering amount of time and became the highest grossing movie of the 1960s and of all time; its long and varied life on home video and primetime television; the bestselling soundtrack and many other related recordings; information behind the stunning Austrian locations; the critical feedback; the many stage revivals; and the continuing references, homages, reunions, and tributes related to it over the many decades since its release.


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Greenpeace activists from left: Hope Kaye, Jennifer Thomas and John Shumaker display a banner near Dow's Texas Operations Plant A facility in Freeport, Texas. The facility is Dow's largest integrated site. Greenpeace issued a 'failed inspection' report to Dow Chemical Company for failing to fully secure the plant and its toxic chemicals against terrorists or catastrophic accidents.
This short video features two of the most majestic creatures, the humpback whale and pygmy killer whale. The humpback whale is one of the largest creatures on Earth. The pygmy killer whale is fairly small and not commonly seen. It is part of the...
Greenpeace Greenwire is an online community that fosters real world connections and activities.
Enjoy the view from above Glacier National Park. It is a truly beautiful place.
Saint Paul Island is nestled in the heart of the Bering Sea. It's scenery and wildlife is gorgeous. In this video, there are bountiful puffins and seals.
Most of the footage in this video was taken on Saint Paul Island. Full disclosure, the...
Take a peak into an Indonesian peatland forest. We hope this video brings you a moment of peace.
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OMG! You might want to look away for this video! Some guys say they like "big butts", but I doubt they are talking about this big! This big beautiful woman tries to shake her bottom in this viral video! FAIL!!!!!
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The social in social science
In a complex and rapidly changing world, social scientific study examines how we...
In a complex and rapidly changing world, social scientific study examines how we produce things, communicate, govern ourselves, understand our environments, and how to solve the problems we face in the organisation of social relations and processes. This unit provides a basic overview of how social science contains deeply embedded cultural assumptions and outlines the important relationship between philosophical thinking and practical research methods in social sciences.
On completion of this unit you should be able to:
- describe why and how we study social phenomena;
- outline how theory can help us to deal with complex evidence;
- give examples of the most appropriate theory;
- identify which concepts are most useful for the task;
- explain how hypotheses are generated;
- summarise what makes our evidence and arguments more plausible.
- Duration 15 hours
- Updated Thursday 14th July 2011
- Advanced level
- Posted under Sociology
- Current section: Introduction
- Learning outcomes
- 1 What does the philosophy of the social science offer?
- 2 Facing the challenges in the social sciences
- 3 What does it mean to practise social science?
- 4 Connecting the social sciences to everyday life
- References
- Acknowledgements
Study this free course
Enrol to access the full course, get recognition for the skills you learn, track your progress and on completion gain a statement of participation to demonstrate your learning to others. Make your learning visible!
The social in social science
In a complex and rapidly changing world, social scientific study examines how we produce things, communicate, govern ourselves, understand our environments, and how to solve the problems we face in the organisation of social relations and processes. This unit provides a basic overview of how social science contains deeply embedded cultural assumptions and outlines the important relationship between philosophical thinking and practical research methods in social sciences.
This material is from our archive and is an adapted extract from The Challenge of the Social Sciences (D820) which is no longer taught by The Open University. If you want to study formally with us, you may wish to explore other courses we offer in this subject area [Tip: hold Ctrl and click a link to open it in a new tab. (Hide tip)] .
Archive content
This is an extract from an Open University course which is no longer available to new students. If you found this interesting you could explore more free Sociology courses or view the range of currently available OU Sociology courses.
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Originally published: Thursday, 14th July 2011
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Combi-air Md Inhaler, Duolin , Combimist | Buy Combi-air Md Inhaler, Duolin , Combimist
Combi-air Md Inhaler, Duolin , Combimist | Buy Combi-air Md Inhaler, Duolin , Combimist
Combi-Air MD inhaler, Duolin , Combimist: Introduction
In low doses, acts relatively selectively at beta2-adrenergic receptors to cause bronchodilation and vasodilation; at higher doses, beta2 selectively is lost, and the drug acts at beta2 receptors to cause typical sympthomimetic cardiac effects.
Combi-Air MD inhaler, Duolin , Combimist: Composition
This medication has been marketed in a form of inhaler which is usually packed in 200 mdi, 30 Inhaler, RotaCapsules, which the strength varies from 50 mcg + 20 mcg, 100 + 40, depending on the diseases that the patient has.
Combi-Air MD inhaler, Duolin , Combimist: Use
This drug is use to help relief and prevention of bronchospasm in patients with reversible obstructive airway disease. Inhalation: Treatment of acute attacks of bronchospasm. This helps prevention of exercise-induced bronchospasm. Adjunct in treating serious hyperkalemia in dialysis patients; seems to lower potassium concentrations when inhaled by patients on hemodialysis.
Combi-Air MD inhaler, Duolin , Combimist: Dosage and administration
To determine the correct dosage and course of medication, always consult your doctor and strictly follow the prescription and instructions you are provided. Adults Oral: Initially, 2 or 4 mg 3-4 times a day PO; may cautiously increase dosage if necessary to 4-8 mg every 4 times a day, not exceed 32 mg/day. Inhalation: Each actuation of earosol dispenser delivers 90 mcg albuterol; 2 inhalations every 4-6 hours; some patients may require only 1 inhalation every 4 hours' more frequent administration or larger number of inhalations not recommended. Pediatrics Oral, tablets: age 6-12 yrs: 2 mg 3-4 times a day. Do not exceed 24 mg/day.
Combi-Air MD inhaler, Duolin , Combimist: Contraindication
If you have been told by your physician that you have history or background hypersensitivity to Levosalbutamol + Ipratropium Bromide, better not to take this drug in order to prevent some allergic reactions or worst illness. Contraindicated with hypersensitivity to albuterol; tachyarrhythmias, tachycardia caused by digitalis intoxication; general anesthesia with halogenated hydrocarbons or cyclopropane; unstable vasomotor system disorders; hypertension; coronary insufficiency, CAD; history of stroke; COPD patients with generative heart disease. Use cautiously with diabetes mellitus; hyperthyroidism; history of seizure disorders; psychoneurotic individuals; labor and delivery; lactation; elderly.
Combi-Air MD inhaler, Duolin , Combimist: Important Precautions
It is important for patients who are taking this drug to be aware on what are necessary precautions to take while under this medication. It is important that patient should stop taking alcoholic beverages it may reduce the effectiveness of the drug. Avoid excess dosage. Do not exceed recommended dosage; adverse effects or loss of effectiveness may result. Read the instructions that come with respiratory inhalant. Inform your doctor when you the patient is experiencing chest pain, dizziness, insomnia, weakness, tremors, or irregular heartbeat, difficulty breathing, productive cough, failure to respond to usual dosage.
Combi-Air MD inhaler, Duolin , Combimist: Side effects
You may experience the following side effects: CNS: restlessness, apprehension, anxiety, fear, CNS stimulations, hyperkinesias, insomnia, tremor, drowsiness, irritability, weakness, vertigo, headache. CV: cardiac arrhythmias, tachycardia, palpitations, angina pain. Dermatologic: sweating, pallor, flushing. GI: nausea, vomiting, heartburn, unusual or bad taste in mouth. GU: increased incidence of leiomyomas of uterus when given in higher than human doses in preclinical studies. Respiratory: Respiratory difficulties, pulmonary edema, coughing, bronchospasm, parodoximal airway resistance with repeated, excessive use of inhalation preparations.
Combi-Air MD inhaler, Duolin , Combimist: storage
Recap inhaler after using so that it can never lost its effectiveness. Place it in a dry and safe place and away from younger children.


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Oct 17, 2014
WASHINGTON [MENL] -- Hamas, in wake of the 50-day war with Israel, hasbeen building a military infrastructure in the West Bank, a report said.
Oct 15, 2014
WASHINGTON [MENL] -- A Libyan city has been captured in the name of IslamicState of Iraq and Levant.
Sep 03, 2014
PKK Attacks ISIL In TurkeyANKARA [MENL] -- The Kurdish Workers Party has reported an attack on IslamicState of Iraq and Levant in Turkey.
May 18, 2014
WASHINGTON [MENL] -- The United States has asserted that Iran expanded itsrecruitment of Shi'ite fighters for the war in Syria.


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For 25 years Camp Chef has elevated the outdoor cooking experience. We are continuing that tradition with the brand-new Camp Chef app.
Camp Chef Mobile AppBy: Thomas B. Jun 25, 2015
Top 5 Picks For Father's DayBy: Admin Jun 8, 2015
Sometimes the hardest thing about Father's Day is finding that ultimate gift for Dad. We went around the office to find the top 5 items that would be the gift that would leave Dad speechless this year.
Men's Health - LUX Pellet GrillBy: Admin Jun 2, 2015
See Your Smokin' Hot Grill Friend in the June Issue of Men's Health Magazine.
Cook's Illustrated Recommends 12" Cast Iron SkilletBy: Admin May 27, 2015The Camp Chef 12" Cast Iron Skillet was tested and approved for recommendation by America's Test Kitchen as published in the June 2015 Issue of Cook's Illustrated.
Zion's Bank Speaking on Business - Camp ChefBy: Admin May 22, 2015
Recently, Chris Redgrave for Zions Bank Speaking on Business, highlighted Camp Chef. Below is the transcript and a link to listen to the mp3.
Bacon Egg and Cheese BurgerBy: Admin May 21, 2015
Breakfast. Lunch. And bacon. All in one bite. A great recipe you will want to try anytime you know you will be grilling.
- 1lb of ground beef
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Company Overview of Cleaver-Brooks, Inc.
Company Overview
221 Law Street
Thomasville, GA 31792
United States
Founded in 1929
Key Executives for Cleaver-Brooks, Inc.
Cleaver-Brooks, Inc. Key Developments
Cleaver-Brooks, Inc., Q3 2015 Fixed Income Call, Feb 18, 2015
P. Welch Goggins, Jr., who has served as President and CEO of Cleaver-Brooks, Inc. since April 1, 2005, will step down from those positions March 31 and assume the role of Chairman Emeritus. Succeeding Mr. Goggins will be Bart Aitken, Group President at St. Louis-based Harbour Group. The two men have worked together since Harbour Group's involvement with Cleaver-Brooks began in late 2012. Mr. Goggins began his career in 1975 with Industrial Boiler Company, which Cleaver-Brooks acquired in 1992. He served in various sales and marketing, operational management, and executive positions with Cleaver-Brooks before becoming president and CEO in 2005. He served as chairman of the American Boiler Manufacturers Association (ABMA) from 2006 to 2007. In his role as Group President, Mr. Aitken has had operating responsibility over the following Harbour Group portfolio groups: Plastic Processing Equipment, Automotive Accessories, Building Components, Lubricating Systems, Home Products, and Boiler Room Solutions. Prior to joining Harbour Group, Mr. Aitken was Vice President and General Manager of the Engineered Products Group at Kennametal Inc. and Greenfield Industries, Inc., and Director of European Operations at Greenfield. Mr. Aitken will continue executing Cleaver-Brooks' existing strategy: focusing on being the most complete boiler-room solutions provider by helping customers run better every day.
Cleaver-Brooks, Inc. recently completed a multi-million dollar plant expansion to its facility in Lincoln, Neb. The company's plant in Lincoln engineers and manufacturers industrial watertube boilers for large manufacturing and industrial facilities serving the utility, global oil sands, petrochemical and heavy process industries, among others. The company added approximately 41,000 square feet to the facility, bringing the total to about 186,000. As a part of the expansion, the company installed two new cranes to handle a combined capacity of up to 200 tons and added a paint and blast booth to the facility.
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Hello People,
I am going on a six days safari in Tanzania in July 02 thru July 10 and alone. I am looking for other travelers who are interested and would like to join me as a group during this safari. Please if you are interested drop me an email and we can organize something. I will be visiting Tarangiri Park, Manyara, the Serengeti and Ngorongoro Crater. My email is firstname.lastname@example.com.
Recent ActivityView all Africa & the Middle East activity »
- 1 Gorrillas in Rwanda
- 2 Trip Report: Madagascar and Rwanda
- 3 Zimbabwe traveling solo
- 5 Malawi with kiddos
- 6 Southern Africa Safari Trip—Best Vacation Ever!!
- 7 Extended wait time at JNB airport
- 8 Capetown, Garden Route & Safari
- 9 Mauritius info request please
- 10 South Africa- Capetown/Safari Planning Help Please
- 11 Tanzania and Kenya tour company?
- 12 New Visa Rules on arrival for Kenya W.E.F 01 July 2015
- 13 WiFi on Safari
- 14 Travel within Africa
- 15 Cape Town - things to do IN THE CITY and where to stay?
- 16 In South Africa, What do Hotels Mean by "Tea and Coffee-making Facilities"?
- 17 Israel itinerary planning
- 18 Africa, closer than ever before?
- 19 Capetown 3-day itinerary?
- 20 My experience of 8 day tour in Morocco
- 21 Private Tour Recommendations To Erg Chebbi
- 22 My Tour in Morocco by 4x4
- 23 Kenya: No longer able to get visa on arrival at airport?
- 24 Seal snorkeling - Capetown
- 25 Luggage Storage Question at O.R. Tambo Int'l Airport
A six Day Safari in Tanzania
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NASA sees Typhoon Halong approaching Japan
NASA's Terra satellite grabbed a look at Typhoon Halong as it was nearing the Japanese islands of Minamidaito and Kitadaito and headed for a landfall in the main islands of southern Japan.
NASA's Terra satellite grabbed a look at Typhoon Halong as it was nearing the Japanese islands of Minamidaito and Kitadaito and headed for a landfall in the main islands of southern Japan.
A visible satellite image from NOAA's GOES-East satellite shows that Post-Tropical Storm Bertha was merging with a frontal system in the North Atlantic Ocean.
Tropical Storm Bertha took a "vacation" in the Bahamas on August 3 and NASA's Terra satellite captured an image of the storm that appeared be centered over "Crooked Island."
Rolling sand dunes in the expansive Rub' al Khali desert on the southern Arabian Peninsula are pictured in this radar image from the Sentinel-1A satellite.
NASA's TRMM satellite measured up Super Typhoon Rammasun's rainfall rates, rainfall totals and cloud heights providing a look at the inner workings and aftermath of the storm.
This week's satellite image was acquired over the eastern part of Mexico City.
This natural-color satellite image was collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the Aqua satellite on July 10, 2014. Each hot spot, which appears as a red mark, is an ...
Polar bear population estimates based on satellite images are similar to aerial estimates, according to a study published July 9, 2014 in the open-access journal PLOS ONE by Seth Stapleton from United States ...
Satellite images have found that Indonesia's ancient forests, a cradle of biodiversity and a buffer against climate change, have shrunk much faster than thought, scientists said on Sunday.
A new study led by the University of Minnesota offers new insights on the long-term future of emperor penguins by showing that the penguins may be behaving in ways that allow them to adapt to their changing ...
Wind-carved ridges and furrows in southeast Iran's Dasht-e Lut salt desert are pictured in this satellite image.
The US government has lifted restrictions on the use of high-quality satellite images in a move that will be welcomed by industry but could have serious privacy implications for the man or woman on the stree ...
On the southwestern coast of Greenland, multiple ice streams that drain the Greenland ice sheet are pictured in this satellite image.
Tropical Cyclone 02A formed in the Arabian Sea as NASA-NOAA's Suomi NPP satellite passed overhead and captured a visible photo of the storm, spotting strongest storms south of its center.
Data from the Meteosat satellite 36,000 km from Earth, has been used to measure the temperature of lava at the Nyiragongo lava lake in the Democratic Republic of Congo. An international team compared data ...


text:
What Handwriting Supposedly Says About You
Things That Will Make You Feel Very Uncomfortable
Brutal Female Bodyguards Training in China
14 Most Bizarre Medical Conditions on Earth
Man Skips Rocks on Frozen Lake & Gets the Surprise of a Lifetime!
This Girl's Fake Pregnancy Prank Totally Backfired
How to Break Free from Zip Ties
'Naked Dresses' in Red Carpet History
10 Foods You Can't Get Legally In The United States
Woman Removes Makeup, Reveals Stunning Transformation
10 Predictions That Really Came True
Abandoned Village Shows You What Life Would Look Like without People
When Terrible Customers Threatened a Bad Yelp Review, This Restaurant Owner Took a Stand
10 Crazy Myths That are Actually True
50 Incredible Pictures That Might Teach You Something
You Won't Believe What This Shadow in the Sea Is!
10 Worst Food Finds
The Terrifying Moment a Spider Jumps Out of a Banana
9 Questions That All Bar Employees Are Tired of Hearing
10 Freaky Projects That Killed Their Creators
The 11 Most Disgusting Fair Foods of All-Time
Daily Dose of Cute: 10 Most Squeal-Worthy Baby Animals
Mystery of the Turquoise Cat: What Caused This Color Change?
29 Of The Most Incredible Structures The World Has Ever Seen
15 Biggest Unsolved Mysteries in the World
The 5 Craziest Laws in The World
Check Out The Cutest Octopus You'll Ever See
This Abandoned Corvette Junkyard Is Probably Worth Millions
20 Adorable Photos That Prove Bears Make Great Parents
10 Complete Technological Failures


text: (Photo by Christian Petersen/Getty Images) [ A.J. Hinch Talks Astros Baseball On "Hot Stove" – VIDEO By Steve Peloquin January 23, 2015 Houston Astros manager A.J. Hinch was a guest on the MLB Network's "Hot Stove" on Thursday. Read More|Comment Category: Local Sports, Sports, Video Tags: a.j. hinch, houston astros Send to a friend! Share on Facebook Share on Twitter


text:
Chopped Judges Take Over the Kitchen in After-Hours Competitionsby Maria Russo in Shows, April 2nd, 2013
No strangers to the uncommon, unusual ingredients that make their way into mystery baskets, Chopped judges have tasted myriad plates of eccentric eats after more than 14 seasons of competition, but they rarely are able to cook with those ingredients for themselves. That is, until now.
In Chopped After Hours, an all-new series on FoodNetwork.com, the panel is taking over the kitchen. For the first time, the judges are trying their hands at identical combinations of ingredients that have sent home chef competitors. They'll cook against the clock in the same amount of time as traditional contestants, but among these friends and colleagues there will be as much eating, drinking and playful joking happening at each station as there is high-quality food preparation. None of the judges will settle for creating anything less than masterful meals, but they know well how to balance work and play — and will surely make time for a cocktail or two and even subject their fellow judges to a few hilariously timed interruptions.
No one knows the Chopped kitchen quite like these longstanding judges, but when faced with odd, disparate ingredients — and their peers' influences — will they be able to turn out top-tier dishes without succumbing to the same challenges as everyday competitors? Check back to Food Network's Chopped headquarters (FoodNetwork.com/Chopped) after the brand-new episode airs Tuesday, April 30 at 10pm/9c to watch the judges in action, and find out if they can succeed where others have been chopped.
Upcoming After Hours Episodes
Tuesday, April 30 at 10pm/9c
Tuesday, May 7 at 10pm/9c
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text:
- Home
- Racing & Wagering
- News / Videos / Photos
- Calendar
- Plan Your Visit
- Parking / Maps / Directions
- Entering Churchill Downs
- General Information
- Guest Services
- Hotel Partner
- Group Sales
- Tours
Plenty of Preakness Stakes Activities at Churchill Downs
Advanced wagering on Saturday's 136th Preakness Stakes (Grade I) at Pimlico Race Course near Baltimore will be offered all day Friday at Churchill Downs.
Churchill Downs to Offer Free General Admission Friday; Coincides with Start of New Paddock Concert Series
As a special "thank you" to the people of Louisville and the Kentuckiana region for another successful Kentucky Derby Week, Churchill Downs will offer free general admission on Friday, May 13.
Big Post-Derby Carryover Pools in Pick 6, Super Hi-5 on Thursday, May 12
Huge carryover pools in Churchill Downs' Pick 6 and Super Hi-5 wagers from Kentucky Derby Day have become an almost annual tradition, and racing fans will be pursuing those big pools again when racing resumes at the historic track on Thursday, May 12.
With Derby 137 Just 30 Days Away, Sign Between Historic Twin Spires Updated
Last week the solid gold trophy that goes to the Kentucky Derby winner arrived at Churchill Downs.
On Wednesday and Thursday, two more potential contenders for the May 7 "Run for the Roses" arrived at the historic Louisville track to continue their training.
Churchill Downs, Susan G. Komen for the Cure Renew Kentucky Oaks Fundraising Partnership
Continuing a commitment to new Kentucky Oaks Day traditions established two years ago, Churchill Downs Racetrack, the home of the world-famous Kentucky Derby and Kentucky Oaks, and Susan G.
NBC Sports Group Reassembles Triple Crown
The NBC Sports Group will broadcast all three legs of horse racing's prestigious Triple Crown, renewing the rights to the Preakness Stakes and reacquiring rights to the Belmont Stakes. As previously announced, NBC and Churchill Downs, Inc. renewed rights to the Kentucky Derby. This marks the first time that all three races will be on one network since NBC aired them in 2005.
Unbeaten Uncle Mo Is Favored Individual Horse in Opening Pool 2011 Kentucky Derby Future Wager
Repole Stable's Uncle Mo, the unbeaten 2-year-old champion of 2010 and winner of last fall's Grey Goose Breeders' Cup Juvenile (Grade I) at Churchill Downs, is a strong individual favorite in the first of three betting pools in Churchill Downs' 2011 Kentucky Derby Future Wager ("KDFW"). But the mutuel field, or "All Others", is expected to again be the bettors' choice when the Feb.
Road to the Roses Kentucky Derby Fantasy Challenge Now Open
Churchill Downs' "Road to the Roses" Kentucky Derby Fantasy Challenge presented by WinStar Farm is back. The free online contest that allows racing fans to manage a stable of Kentucky Derby contenders during the three-month buildup to the $2 million Kentucky Derby Presented by Yum! Brands (Grade I) is now open for registration.
MainGate, Churchill Downs Launch New KentuckyDerbyStore.com
MainGate Inc., the premier event retail and online merchandising company in the country, and Churchill Downs, home of the world's most legendary racetrack and the Kentucky Derby, announce a three-year partnership for MainGate to be an official licensee, handle official off-site retail locations and to launch the new Kentucky Derby e-commerce website, KentuckyDerbyStore.com.
Churchill Downs' Trackside OTB Closed Thursday, Jan. 20, In Anticipation of Winter Storm
An approaching winter storm has prompted Churchill Downs officials to cancel simulcast wagering for Thursday, Jan. 20, at its Trackside at Churchill Downs off-track betting facility.


text:
Mens GogglesAll Brands of Snowboard Goggles at the largest selection and best prices all under one roof at The-House.com. Mens Snowboard Goggles are looking for a good home! We need your help finding fresh powder, sick parks, tons of snow and good times for these puppies to look at with glee and excitement. Won't you do your part and adopt anew pair today? The House. Kings of stoke since 1982.
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text:
Every Thursday - Make Your Own Chocolate Bar! (KAILUA)
- Food & Drink
- 20 Kainehe St, Honolulu, HI, 96734
Tequila and Chocolate Pairing
Madre Chocolate
Friday, August 29, 2014 from 7:30 PM to 9:00 PM (HST)
Here at Madre we can't get enough of our chocolate paired with spirits. Next up on our quest is Tequila and chocolate. Nat of Madre Chocolate will guide you through a tasting and pairing of smooth, honey toned tequila with our rich dark chocolate. Come ready to enjoy an evening of smooth sweet mescals and some piney aged tequila among others. We'll let you be the judge and all find our best pairings, talk about how all these delicious liquors are made, and then let you pick the winning combo.
Cancellation Policy:
We offer a full refund, minus a $5 booking fee, if you cancel prior to 2 days before the event date. For cancellations occuring within 2 days of the event, we can offer to rebook you for another date or apply your credit to chocolate.
Madre Chocolate reserves the right to cancel any event due to inclement weather, farm conditions, failure to meet registration minimums or other reasons seen fit.
All alcohol is complimentary with the purchase of this class.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.