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Publications (14)58.63 Total impact
- SourceAvailable from: Joachim Rudolph
Article: Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss[Show abstract] [Hide abstract]
ABSTRACT: Ghrelin, through action on its receptor, GH secretagogue receptor type 1a (GHS-R1a), exerts a variety of metabolic functions including stimulation of appetite and weight gain and suppression of insulin secretion. In the present study, we examined the effects of novel small-molecule GHS-R1a antagonists on insulin secretion, glucose tolerance, and weight loss. Ghrelin dose-dependently suppressed insulin secretion from dispersed rat islets. This effect was fully blocked by a GHS-R1a antagonist. Consistent with this observation, a single oral dose of a GHS-R1a antagonist improved glucose homeostasis in an ip glucose tolerance test in rat. Improvement in glucose tolerance was attributed to increased insulin secretion. Daily oral administration of a GHS-R1a antagonist to diet-induced obese mice led to reduced food intake and weight loss (up to 15%) due to selective loss of fat mass. Pair-feeding experiments indicated that weight loss was largely a consequence of reduced food intake. The impact of a GHS-R1a antagonist on gastric emptying was also examined. Although the GHS-R1a antagonist modestly delayed gastric emptying at the highest dose tested (10 mg/kg), delayed gastric emptying does not appear to be a requirement for weight loss because lower doses produced weight loss without an effect on gastric emptying. Consistent with the hypothesis that ghrelin regulates feeding centrally, the anorexigenic effects of potent GHS-R1a antagonists in mice appeared to correspond with their brain exposure. These observations demonstrate that GHS-R1a antagonists have the potential to improve the diabetic condition by promoting glucose-dependent insulin secretion and promoting weight loss.Endocrinology 12/2007; 148(11):5175-85. DOI:10.1210/en.2007-0239 · 4.64 Impact Factor
Article: A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents[Show abstract] [Hide abstract]
ABSTRACT: Selective activation of the neuropeptide Y (NPY)2 receptor to suppress appetite provides a promising approach to obesity management. A selective NPY2 polyethylene glycol-conjugated (PEGylated) peptide agonist is described that consists of a peptide core corresponding to residues 13 to 36 of human peptide YY (PYY) and a nonpeptidic moiety (2-mercaptonicotinic acid) at the peptide N terminus that is derivatized with 20-kDa monomethoxypolyethylene glycol. The PEGylated peptide elicits a dose-dependent reduction in food intake in lean C57BL/6 mice and Wistar rats that persists for 72 and 48 h, respectively. The effect on food intake in lean C57BL/6 mice is blocked by the selective NPY2 antagonist BIIE0246 (N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide formate). A dose-dependent reduction in body weight in diet-induced obese (DIO) mice is seen following daily dosing for 14 days. The reduction in body weight is sustained following dosing for 40 days, and it is accompanied by an increase in plasma adiponectin. Improvements in glucose disposal and in plasma insulin and glucose levels that are risk factors for type II diabetes are observed following once-daily subcutaneous dosing in DIO mice. The results provide evidence from two animal species that the long-acting selective NPY2 peptide agonist has potential for obesity management.Journal of Pharmacology and Experimental Therapeutics 12/2007; 323(2):692-700. DOI:10.1124/jpet.107.125211 · 3.86 Impact Factor
Article: Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity[Show abstract] [Hide abstract]
ABSTRACT: The peptide hormone ghrelin is the endogenous ligand for the type 1a growth hormone secretagogue receptor (GHS-R1a) and the only currently known circulating appetite stimulant. GHS-R1a antagonism has therefore been proposed as a potential approach for obesity treatment. More recently, ghrelin has been recognized to also play a role in controlling glucose-induced insulin secretion, which suggests another possible benefit for a GHS-R1a antagonist, namely, the role as an insulin secretagogue with potential value for diabetes treatment. In our laboratories, piperidine-substituted quinazolinone derivatives were identified as a new class of small-molecule GHS-R1a antagonists. Starting from an agonist with poor oral bioavailability, optimization led to potent, selective, and orally bioavailable antagonists. In vivo efficacy evaluation of selected compounds revealed suppression of food intake and body weight reduction as well as glucose-lowering effects mediated by glucose-dependent insulin secretion.Journal of Medicinal Chemistry 11/2007; 50(21):5202-16. DOI:10.1021/jm070071+ · 5.48 Impact Factor
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ABSTRACT: A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alpha.Bioorganic & Medicinal Chemistry Letters 09/2007; 17(15):4369-73. DOI:10.1016/j.bmcl.2007.03.057 · 2.33 Impact Factor
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ABSTRACT: Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit increased insulin secretion. Using an HTS approach, we have identified quinoline-based PDE-10A inhibitors as insulin secretagogues in vitro. Optimized compounds were evaluated in vivo where improvements in glucose tolerance and increases in insulin secretion were measured.Bioorganic & Medicinal Chemistry Letters 05/2007; 17(10):2869-73. DOI:10.1016/j.bmcl.2007.02.061 · 2.33 Impact Factor
Article: Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: Synthesis, structure-activity relationship, and in vivo efficacy[Show abstract] [Hide abstract]
ABSTRACT: Compounds that simultaneously activate the three peroxisome proliferator-activated receptor (PPAR) subtypes alpha, gamma, and delta hold potential to address the adverse metabolic and cardiovascular conditions associated with diabetes and the metabolic syndrome. We recently identified the indanylacetic acid moiety as a well-tunable PPAR agonist head group. Here we report the synthesis and structure-activity relationship (SAR) studies of novel aryl tail group derivatives that led to a new class of potent PPAR pan agonists. While most of the tail group modifications imparted potent PPAR delta agonist activity, improvement of PPAR alpha and gamma activity required the introduction of new heterocyclic substituents that were not known in the PPAR literature. Systematic optimization led to the discovery of 4-thiazolyl-phenyl derivatives with potent PPAR alpha/gamma/delta pan agonistic activity. The lead candidate from this series was found to exhibit excellent ADME properties and superior therapeutic potential compared to known PPAR gamma activating agents by favorably modulating lipid levels in hApoA1 mice and hyperlipidemic hamsters, while normalizing glucose levels in diabetic rodent models.Journal of Medicinal Chemistry 04/2007; 50(5):984-1000. DOI:10.1021/jm061299k · 5.48 Impact Factor
Article: Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes[Show abstract] [Hide abstract]
ABSTRACT: Type 2 diabetes is characterized by reduced insulin secretion from the pancreas and overproduction of glucose by the liver. Glucagon-like peptide-1 (GLP-1) promotes glucose-dependent insulin secretion from the pancreas, while glucagon promotes glucose output from the liver. Taking advantage of the homology between GLP-1 and glucagon, a GLP-1/glucagon hybrid peptide, dual-acting peptide for diabetes (DAPD), was identified with combined GLP-1 receptor agonist and glucagon receptor antagonist activity. To overcome its short plasma half-life DAPD was PEGylated, resulting in dramatically prolonged activity in vivo. PEGylated DAPD (PEG-DAPD) increases insulin and decreases glucose in a glucose tolerance test, evidence of GLP-1 receptor agonism. It also reduces blood glucose following a glucagon challenge and elevates fasting glucagon levels in mice, evidence of glucagon receptor antagonism. The PEG-DAPD effects on glucose tolerance are also observed in the presence of the GLP-1 antagonist peptide, exendin(9-39). An antidiabetic effect of PEG-DAPD is observed in db/db mice. Furthermore, PEGylation of DAPD eliminates the inhibition of gastrointestinal motility observed with GLP-1 and its analogues. Thus, PEG-DAPD has the potential to be developed as a novel dual-acting peptide to treat type 2 diabetes, with prolonged in vivo activity, and without the GI side-effects.Journal of Endocrinology 03/2007; 192(2):371-80. DOI:10.1677/JOE-06-0018 · 3.59 Impact Factor
Article: Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups—new classes of PPAR γ/δ and PPAR α/γ/δ agonists[Show abstract] [Hide abstract]
ABSTRACT: Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands. Modification of the substituents on the linker and the heterocycle tail group allowed for the modulation of the selectivity at the different receptor subtypes. Compound 33 was evaluated in vivo, where it displayed the desired reduction of glucose levels and increase in HDL levels in various animal models.Bioorganic & Medicinal Chemistry Letters 03/2007; 17(4):1056-61. DOI:10.1016/j.bmcl.2006.11.025 · 2.33 Impact Factor
Article: Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal[Show abstract] [Hide abstract]
ABSTRACT: VPAC2P-PEG is a VPAC2 receptor agonist peptide that acts as a glucose-dependent insulin secretagogue. Proteolysis by DPPIV may contribute to the in vivo clearance of VPAC2P-PEG. Here, the N-terminus of VPAC2P-PEG is modified by N-terminal acetylation to impart DPPIV resistance. The acetylated peptide, Ac-VPAC2P-PEG, is a selective and potent VPAC2 agonist, resistant to DPPIV proteolysis, and exhibits substantially improved half-life and glucose disposal in rodents. Ac-VPAC2P-PEG has therapeutic potential for diabetes management.Journal of Medicinal Chemistry 01/2007; 49(25):7545-8. DOI:10.1021/jm0609059 · 5.48 Impact Factor
Article: Engineering Novel VPAC2Selective Agonists with Improved Stability and Glucose-Lowering Activity in Vivo[Show abstract] [Hide abstract]
ABSTRACT: A previously described VPAC2-selective agonist, BAY 55-9837 (peptide HSDAVFTDNYTRLRKQVAAKKYLQSIKNKRY), had several limitations with respect to its potential as an insulin secretagogue for the treatment of type 2 diabetes. These limitations were primarily poor stability in aqueous buffer and short duration of action in vivo. In this report, we describe a series of novel analogs of BAY 55-9837 that were designed around the likely degradation mechanisms and structure-activity relationship of this peptide with a view to overcoming its limitations. These analogs were tested for improved liquid stability and retention of VPAC2-selective binding and activation, as well as prolonged activity in vivo. Although several degradation mechanisms were possible based on the degradation pattern, it was determined that deamidation at the two asparagines (N9 and N28) was the major instability determinant. Changing these two asparagines to glutamines did not negatively affect VPAC2-selective binding and activation. The double glutamine mutein analog, BAY(Q9Q28), retained full VPAC2 activity and selectivity while displaying no significant degradation when stored at 40 degrees C for 4 weeks. This is in contrast to BAY 55-9837, which showed greater than 80% degradation when stored at 40 degrees C for 2 weeks. A cysteine was added to the C terminus of BAY(Q9Q28), followed by site-specific cysteine conjugation with a 22- or 43-kDa polyethylene glycol (PEG) to yield BAY(Q9Q28C32)PEG22 or BAY(Q9Q28C32)PEG43, respectively. These PEGylated peptides retain the ability to selectively bind and activate the VPAC2 receptor and have prolonged glucose-lowering activity in vivo.Journal of Pharmacology and Experimental Therapeutics 07/2006; 320(2):900-906. DOI:10.1124/jpet.106.112276 · 3.86 Impact Factor
Article: Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonist[Show abstract] [Hide abstract]
ABSTRACT: The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, whereas glucagon stimulates gluconeogenesis and glycogenolysis in the liver. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach for the treatment of type 2 diabetes. Toward this end a series of hybrid peptides made up of glucagon and either GLP-1 or exendin-4, a GLP-1 agonist, was engineered. Several peptides that bind to both the GLP-1 and glucagon receptors were identified. The presence of glucagon sequence at the N terminus removed the dipeptidylpeptidase IV cleavage site and increased plasma stability compared with GLP-1. Targeted mutations were incorporated into the optimal dual-receptor binding peptide to identify a peptide with the highly novel property of functioning as both a GLP-1 receptor agonist and a glucagon receptor antagonist. To overcome the short half-life of this mutant peptide in vivo, while retaining dual GLP-1 agonist and glucagon antagonist activities, site-specific attachment of long chained polyethylene glycol (PEGylation) was pursued. PEGylation at the C terminus retained the in vitro activities of the peptide while dramatically prolonging the duration of action in vivo. Thus, we have generated a novel dual-acting peptide with potential for development as a therapeutic for type 2 diabetes.Journal of Biological Chemistry 06/2006; 281(18):12506-15. DOI:10.1074/jbc.M600127200 · 4.60 Impact Factor
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ABSTRACT: A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.Bioorganic & Medicinal Chemistry Letters 02/2006; 16(2):297-301. DOI:10.1016/j.bmcl.2005.10.008 · 2.33 Impact Factor
Article: Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose[Show abstract] [Hide abstract]
ABSTRACT: Elevation of plasma free fatty acids has been linked with insulin resistance and diabetes. Inhibition of lipolysis may provide a mechanism to decrease plasma fatty acids, thereby improving insulin sensitivity. Hormone-sensitive lipase (HSL) is a critical enzyme involved in the hormonally regulated release of fatty acids and glycerol from adipocyte lipid stores, and its inhibition may thus improve insulin sensitivity and blood glucose handling in type 2 diabetes. In rat adipocytes, forskolin-activated lipolysis was blocked by in vitro addition of a potent and selective HSL inhibitor or by prior treatment of the animals themselves. Antilipolytic effects also were demonstrated in overnight-fasted mice, rats, and dogs with species-dependent effects on plasma free fatty acid levels but with similar reductions in plasma glycerol being observed in all species. Inhibition of HSL also reduced hyperglycemia in streptozotocin-induced diabetic rats. The data support a connection between adipose tissue lipolysis and plasma glucose levels.Journal of Pharmacology and Experimental Therapeutics 01/2006; 315(3):1396-402. DOI:10.1124/jpet.105.086926 · 3.86 Impact Factor
Article: A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal - A potential therapy for type 2 diabetes[Show abstract] [Hide abstract]
ABSTRACT: Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) activate two shared receptors, VPAC1 and VPAC2. Activation of VPAC1 has been implicated in elevating glucose output, whereas activation of VPAC2 may be involved in insulin secretion. A hypothesis that a VPAC2-selective agonist would enhance glucose disposal by stimulating insulin secretion without causing increased hepatic glucose production was tested using a novel selective agonist of VPAC2. This agonist, BAY 55-9837, was generated through site-directed mutagenesis based on sequence alignments of PACAP, VIP, and related analogs. The peptide bound to VPAC2 with a dissociation constant (K(d)) of 0.65 nmol/l and displayed >100-fold selectivity over VPAC1. BAY 55-9837 stimulated glucose-dependent insulin secretion in isolated rat and human pancreatic islets, increased insulin synthesis in purified rat islets, and caused a dose-dependent increase in plasma insulin levels in fasted rats, with a half-maximal stimulatory concentration of 3 pmol/kg. Continuous intravenous or subcutaneous infusion of the peptide reduced the glucose area under the curve following an intraperitoneal glucose tolerance test. The peptide had effects on intestinal water retention and mean arterial blood pressure in rats, but only at much higher doses. BAY 55-9837 may be a useful therapy for the treatment of type 2 diabetes.Diabetes 05/2002; 51(5):1453-60. DOI:10.2337/diabetes.51.5.1453 · 8.47 Impact Factor


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fotoscoolRead MoreFounded with the objective of simplifying the often overcomplicated art of digital photography, fotoscool employs a team of seasoned instructors—each a longtime professional with a celebrated career—to guide photography students through seminars and workshops held across the country. Keeping their overarching objective of simple-yet-entertaining instruction in mind, savvy teachers design each session to get participants on their feet with hands-on activities such as interactive exercises, on-location shoots in scenic locales, and bonding human-camera trust falls. In an effort to branch out of the classroom, fotoscool also periodically hosts tours that ferry photo enthusiasts to scenic far-flung locales for extended shooting lectures and on-site experience.Redeem on locationCalgary, AB CA
Fine Art Bartending School WinnipegRead MoreEquipped with varied experience and an in-depth knowledge of alcohol and service regulations, the instructors at Fine Art Bartending School guide their students toward mixology mastery or job placement in the bartending industry during intensive five-day courses. While many schools focus solely on the craft, Fine Art's instructors also hone customer service skills through a guest bartending program at local bars and clubs?teaching students tip-enhancing approaches and how to graciously deflect customer's attempts at Bryan Adams sing-alongs. They also hold individual classes targeted at everyday drinkers, divulging industry-style instructions for blending specific drinks, performing difficult mixes, or pouring the perfect beer.222 Osborne St.Winnipeg, MB CA
Prelude MusicRead MoreCreative expression starts early at Prelude Music. The instructors here lead music classes for babies as young as 6 months?helping them create music alongside parents through singing, chants, instruments, and other tools. Each passing melody builds core skills (both mental and physical), and as musicians grow older, so does the curriculum. These Melodies & ABC?s classes transition into one-one-one lessons in piano, guitar, voice, and music theory. All of these programs are guided by experienced instructors, who hold more music degrees and certifications than you could shake a maraca at. Their ranks even include therapists, who use music as a way to bolster mental and physical health.218 Lenore St.Winnipeg, MB CA
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Bronx, NY (Sports Network) - Clay Buchholz threw seven strong innings and received plenty of offensive support from his Boston teammates, as the Red Sox cruised to a second straight win over the rival New York Yankees with a 7-4 decision.
Buchholz (1-0) held the Yankees to one run and six hits in a sharp first effort of the season, and the Red Sox staked the right-hander to a comfortable 6-0 lead after 2 1/2 innings.
"It's always good to get off on the right foot," Buchholz said.
Boston pounded out 13 hits on the night, with Daniel Nava, Dustin Pedroia, Jarrod Saltalamacchia and Shane Victorino each collecting two while driving in a run.
Jacoby Ellsbury added a two-run single for the Red Sox, who got their 2013 campaign off to an excellent beginning with Monday's 8-2 triumph at Yankee Stadium.
Vernon Wells' three-run homer in the bottom of the eighth was one of few bright spots for New York, which lost starting pitcher Hiroki Kuroda to an injured right hand after being struck by a Victorino line drive in the top of the second.
Kuroda (0-1) was charged with two runs and surrendered four hits before being forced to exit with one out in the second.
Wells ended 3-for-4 for the Yankees, with Travis Hafner delivering a solo homer in the setback.
"We just have to do a little more than we did tonight," Wells said.
Kuroda served up three hits, the last a run-scoring single from Saltalamacchia, in the first inning before having Victorino's liner to begin the second deflect off his pitching hand. He then hit Jackie Bradley Jr. with a pitch, walked Ellsbury two batters later to load the bases and unintentionally plunked Nava in the lower leg to force in a run prior to being removed.
The Red Sox later teed off on replacement Cody Eppley to extend the margin. Victorino singled home Saltalmacchia in the third for a 3-0 advantage, then crossed the plate on Bradley's base hit up the middle before a Jose Iglesias double put two men in scoring position for Ellsbury, who ripped a single to center to knock in both runners and put Boston ahead by a 6-0 score.
Buchholz, meanwhile, was cruising along. The right-hander set down seven straight Yankees before Hafner reached the seats with two outs in the fourth, then yielded just two hits and a walk over his final three innings of work.
He left with a 7-1 lead after the Sox tacked on another run in the sixth. Ellsbury reached on a fielder's choice, moved to third on a Nava double and crossed the plate on a Pedroia ground ball.
A hit batsman and Kevin Youkilis' single in the eighth set the stage for Wells' two-out blast off Alfredo Aceves that cut New York's deficit to 7-4, but the Yankees couldn't get a runner past first against closer Joel Hanrahan in the ninth.
The Yankees have now lost their last six games dating back to last year's
American League Championship Series, during which the Bronx Bombers were swept
by Detroit in the best-of-seven set ... Buchholz had gone 0-5 over his final
eight starts of last season, with his most recent victory coming at Baltimore
on August 16. He was also 0-2 with a 15.26 ERA in two starts against New York
in 2012, including a shelling at Yankee Stadium in which he was rocked for
eight runs in 1 2/3 innings ... Ex-Red Sox Youkilis finished 2-for-4 for the
Yankees, with Iglesias recording two hits in four at-bats for Boston.
Former Heisman Trophy winners Matt Leinart, Eric Crouch and Rashaan Salaam are among 76 Football Bowl Subdivision players on the ballot for election into the 2016 class of the College Football Hall of Fame.
The regular season in the NASCAR Sprint Cup Series has reached its midpoint, with 13 races completed and 13 to go before the championship Chase begins.
The Houston Texans have signed defensive lineman Brandon Deaderick, who played last season with the New Orleans Saints.
The Toronto Blue Jays activated catcher Dioner Navarro from the 15-day disabled list following a 2-0 loss to the Washington Nationals in the opener of Tuesday's doubleheader.
Sacramento Kings forward Carl Landry underwent surgery on Tuesday to repair a torn ligament in his right wrist, the team said.
The Montreal Canadiens revealed on Tuesday that defenseman Jeff Petry has agreed to terms on a six-year contract extension.


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2MTL 379: Throwback Review of "Rise of the Cybermen"
If you were a classic fan who was on Team Cyberman rather than Team Dalek, this episode was long overdue. But was "Rise of the Cybermen" a proper re-introduction of the classic villains? Or were there too many stompy missteps out of the gate?
2MTL 378: Paging Pertwee
2MTL comes out of a weeks-long retirement at a time when it would appear it would be easy enough to bring back the Third Doctor…
2MTL 377: (Not) Daydreaming of Being the Doctor
Why would a man-child geek culture hound, who has immersed himself in your Star Treks and Star Wars and Jason of Star Commands as a child, dreaming of being those characters and living in those worlds, become obsessed to the point of podcasting about a character, the Doctor, whom he absolutely cannot imagine being?
Asking for […]
2MTL 376: Torchwood Returns
It was big news, even for Big Finish: Torchwood and Captain Jack Harkness are back. The producers are holding their cards close, so you know what that means: rampant speculation and bucket-listing from your humble host!
2MTL 375: Titan Comics and the Forgotten Doctor
There was a time, you know. A time when Jack Harkness had never died. Let's go back to the time of the Forgotten Doctor, courtesy of Titan Comics.
2MTL 374: "The Stone Rose" Revisited
My The Audio Guide to Babylon 5 cohost, occasional 2MTL contributor and spouse, Shannon, returns with a review of the recently reissued The Stone Rose by Jacqueline Rayner — but does she do so with Rose-colored glasses?
2MTL 373: "The Girl in the Fireplace" Throwback Review
"The Girl in the Fireplace" is a glimpse into the future: Steven Moffat's second Doctor Who story pretty much establishes the format that the show will follow when he takes over as showrunner and casts Smith, Gillan and Darvill. Plus, we revisit a 2MTL topic from 2009 and marvel at […]
2MTL 372: Three Doctors, One Paul Cornell
Paul Cornell has a dream project with Titan Comics: a crossover event with all three stars of their ongoing DOCTOR WHO series! It's early yet, so Paul is circumspect about the plot, but you can find out who his artistic collaborator will be and discover the tone of this highly anticipated team-up of […]
2MTL 371: Conventional Wisdom
Reflections on conventions in general and Gallifrey One in particular: why they matter and how I hope to make the most of them this year.
Special thanks to all of the people with positive feedback on my segment for Radio Free Skaro Live!
2MTL 370: Celebrating the 10th Anniversary of "Rose"
From Gallifrey One, here's my celebration of the 10th anniversary of the airing of "Rose." Thanks to my friends at Radio Free Skaro for inviting me to share the stage once more for their Friday morning live show, "Behind the Magic".
Tags2MTL updates appreciation BBC America Big Finish casting Christmas specials Clara classic series comics companions continuity conventions culture Doctor Who abroad DWO WhoCast Eleventh Doctor fandom Gallifrey One guest appearance guest commentary Hurricane Who interview Matt Smith new series online pontification regeneration review romance in the TARDIS Russell T. Davies Series 1 Series 5 Series 6 Series 7 Series 8 Steven Moffat Tenth Doctor Throwback Toby Hadoke Tony Lee Torchwood Torchwood: Miracle Day TV biz Twelfth Doctor U.K. guest reviews


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Birmingham's Aluko staying with Aberdeen
Birmingham City are allowing striker Sone Aluko to stay on-loan at Aberdeen.
"It's just a matter of sorting out the finances," Dons boss Jimmy Calderwood said. "Hopefully if it's the same deal as before he (Aluko) will be with us to the end of the season."


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Today on Road Traffic Technology
London Cycle Superhighways/projects/10497/main.jpg
Cycle Superhighways (CS) are bicycle paths extending from external parts of London to central London.
June's top stories: SSL's wins $1.75bn contract, Samsung's new Safety Truck/uploads/newsarticle/4614518/main.jpg
Saint-Laurent Group (SSL) consortium wins $1.75bn contract from Canada, Samsung launched its new 'see-through' Safety Truck and Vinci...
Botlek-Bridge Replacement, A15 Highway, Rotterdam/projects/10485/main.jpg
The new Botlek-Bridge is a moveable / lifting bridge that is being constructed to replace the existing Botlek-Bridge, as part of the...
Yavuz Sultan Selim Bridge, Istanbul/projects/10430/main.jpg
Yavuz Sultan Selim Bridge (3rd Bosphorus Bridge) is being constructed over the Bosphorus Strait in Istanbul, Turkey.
Latest News
A series of road improvements worth C$9.1m ($7.1m) have started on Highway 14 in and around Sooke, Canada, as part of a partnership between the Province of British Columbia and the District of...
Latest Suppliers
With a heritage of over 130 years in the ticketing industry, beginning with the Bell Punch Company in 1878, METRIC is at the forefront of design and innovation, and has a major presence...
Latest Projects
Cycle Superhighways (CS) are bicycle paths extending from external parts of London to central...
Latest Products & Services
The LMS5xx laser measurement sensor is the successor of the widely used LMS2xx series. It offers a host of new features to boost performance in existing applications and break ground for...
Latest Features
Saint-Laurent Group (SSL) consortium wins $1.75bn contract from Canada, Samsung launched its new 'see-through' Safety Truck and Vinci Concessions has been selected to build the Regina...
Latest White Papers
Modern traffic management on road, rail and sea routes is geared towards safety, efficiency and a good environmental balance. Rugged sensor solutions provide reliable control and monitoring...
Latest Videos
A company video from A.D. Engineering showcasing their products and services.
Latest Press Releases
BRAUMS Pty Ltd is pleased to announce that it has entered into a binding agreement to purchase the business and assets of KVM Traffic Services (KVM) from Licola Cape Pty...


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User:Charles Fracchia
From OpenWetWare
Revision as of 13:51, 20 May 2009 by Charles Fracchia (Talk | contribs)
I am a new member of OpenWetWare!
Contact Info
- Phone (UK): +44(0)7942598913
- Phone (Belgium): +32(0)472567310
- Email: charlesfracchia <at> gmail <dot> com
- Skype: charlesfracchia
- www.charlesfracchia.com
- Currently: Student at Imperial College London, London, United Kingdom
- Lycée Français Jean Monnet, Brussels, Belgium 1993 - 2007
- Franco-British bilingual scientific section (OIB)
o Third language: Spanish o Elected class representative since 2003 o Elected students' representative in School Council (Conseil de Vie Lycéenne) 2005-2007 o Elected last year students' representative for the school financial and administrative Council (Conseil d'Établissement)
• Imperial College London 2007 - 2011 o Biology with a year in Industry • Second Year courses: Advanced Molecular Biology, Statistics, Bacteriology, Immunology, Virology and Genetics
Research interests
- Interest 1
- Interest 2
- Interest 3
- Goldbeter A and Koshland DE Jr. . pmid:6947258.
- JACOB F and MONOD J. . pmid:13718526.
leave a comment about a paper here
- Mark Ptashne. A genetic switch. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, 2004. isbn:0879697164.


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46 year old man | Los Angeles, CA, USA | Seeking women 30-51 within 50 miles
Active within 24 hours
Here is where I am supposed to describe myself...
Here is where I am supposed to describe myself so total strangers will evaluate and judge me. I believe we are the summation of our beliefs, tastes, aspirations, knowledge, relationships and stuff. I would like to think that I am not a very complicated person, but after reflecting on what to write here I have discovered that I am a train wreck. Damn these profiles! 1 - I can cross my eyes and can't roll me, but I wish it were the other way around 2 - Reading the Snapple fact of the day from the cap of a bottle of Snapple makes me happy. (if that doesn't turn you on, well you are out of luck) 3 - I can nail most movie quotes. Proving once and for all that I know everything about nothing 4 - I am a good DJ but I have NO other musical talent, and not even spinning. So after further thought, I guess I have no musical talent 5 - There is nothing better than when your girlfriend leaves your place and it still smell like her (note: I am talking about general odor not well…um you know) 7 - I have trust issues. Mostly because raisin cookies look like chocolate chip cookies 8 - I would rather try to carry 10 plastic grocery bags in each hand than make 2 trips 9 - Parents and animals love me, it's their daughters/owners that are the issue Rants: 1 - Why do people write checks in the fast lane at the supermarket? I hate that. I'm guessing they are the same people that jam up the freeways and get on the elevator at the last second only to stop at the floor just before mine. 2 - Is it too much to ask for Starbucks to have more than 1 container of Half and Half since the one I always get is empty!! 3 - Why was learning cursive necessary? In all seriousness, I am a very driven and passionate guy who enjoys the company of others and a like minded partner. I have been told over and over that I am a "keeper" but I haven't found someone with whom I can share my life. While I am funny and kind of a smartass at times, I am a well-educated and successful guy. I hope to find a sensual and energetic partner that can be my lifelong dream or wants to dress me up as a fireman and have me "rescue her." (Either one works for me) btw, I am actually 51. Match matching needed some help...Before you ask, my pics are accurate and taken with the last 12 months. Hope your's are too 😳 Best of luck to you in your matchmaking endeavors!
Coffee and conversation , Cooking , Dining out , Fishing/Hunting , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing sports , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Auto racing / Motorcross, Dancing, Football, Running, Skiing, Swimming
I exercise 5 or more times per week.
Don't display my sign
Middle of the Road
Top Restaurants (ie Osteria Mozza and Bazaar in LA and Catch in NY), The Edison, Asia, Europe, Hawaii
1 - Being with a sensual and intelligent woman 2 - Travel anywhere in the world...well most anywhere 3 - Music - old/new (The Cure, Depeche Mode, Tiesto, Armin van Buuren, Swedish House Mafia) 4 - Movies - Action, Drama, Foreign
Great food, Drinks, Spontaneous road trips or extended weekends to random and distant locations, Working Out, Movies, Dancing, Beach, Just Hanging Out
Flash Boys, David and Goliath, The Buy Side, Blink, Outliers, The Big Short
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|6'2" (187cms)
|4'10" (147cms) to 6'2" (187cms)
|Body type:
|Athletic and toned
|Slender, Athletic and toned
|Black, Blue, Brown, Grey, Green, Hazel
|Light brown
|Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way
|Social Drinker
|Social Drinker
|Executive / Management
|No preference
|$50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married
|Never Married, Widow / Widower, Currently Separated, Divorced
|Have kids:
|Yes, and they sometimes live at home (1)
|No preference
|Wants kids:
|I'll tell you later
|No preference
|White / Caucasian
|Asian, Black / African descent, East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian, Other
|Spiritual but not religious
|No preference
|Graduate degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral
Undergrad - Rutgers Grad (Engineering) - USC Grad (MBA) - UCLA


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Organiser Stewart Noble, chairman of Helensburgh Heritage Trust, has announced that the following events will be taking place in the vicinity of Helensburgh Pier in the afternoon (timings to be confirmed - see below):
Organiser Stewart Noble, chairman of Helensburgh Heritage Trust, has announced that the following events will be taking place in the vicinity of Helensburgh Pier in the afternoon (timings to be confirmed - see below):
Last Updated ( Friday, 27 July 2012 18:30 )Read more...
AN art collector who has just bought a second painting by 'Glasgow Girl' Bessie MacNicol would like to find out more about its Helensburgh history.
Last year Jim Smith bought Bessie's 1904 work, 'Lady with a Fan', a portrait of a model known only as Deborah. Early in June he learnt that another painting by her, entitled 'Margaret', was going under the hammer at Great Western Auctions in Glasgow — and he made a successful bid.
Last Updated ( Sunday, 15 July 2012 11:51 )Read more...
ON Saturday August 4 Helensburgh will be celebrating one of the most important events in its history, and indeed in the history of the West of Scotland.
The first voyage of Henry Bell's Comet took place in August 1812 — this was the first commercial steamship in Europe, while Henry Bell himself was the first recorded Provost of Helensburgh.
Last Updated ( Saturday, 14 July 2012 11:58 )Read more...
DO you recognise anyone in this Second World War photo, taken about 1942-3 at the Marine Aircraft Experimental Establishment at Rhu, which was officially known as RAF Helensburgh for security reasons?
Retired Merseyside local newspaper editor Robin Bird, whose father Bob was a photographer at MAEE and took this picture, has written and published one book about the top secret establishment, 'Top Secret War Bird of World War Two' — and he is hoping to find out who is in the picture for his next book.
Last Updated ( Sunday, 08 July 2012 14:00 )Read more...
A PAINTING by a well known Kilcreggan artist was sold at auction in Salisbury, Wiltshire, on Wednesday June 13.
Entitled 'Boatyard at Buckie, Scotland', it is the work of Arthur Henry Turner who specialised in scenes relating to sailing and the sea, and it was sold by Robert Perera Fine Art of Lymington, Hampshire, at the Woolley and Wallace auction to an unknown buyer for £150.
Last Updated ( Thursday, 14 June 2012 14:58 )Read more...
AS this year's Anderson Trust Collection exhibition in Helensburgh Library enters its final few weeks, it is an appropriate time to look at the work of the late Nance Anderson MBE JP as a collector.
The current exhibition upstairs in the West King Street library — adjacent to the new Heritage Room set up by Helensburgh Heritage Trust — includes almost all the pictures which formed the original Anderson Trust Collection following my aunt's death in 1980.
Last Updated ( Sunday, 27 May 2012 10:03 )Read more...
HELENSBURGH Heritage Trust was delighted to fulfil a sixteen-year dream on May 1 with the opening of its Heritage Room in Helensburgh Library in West King Street.
But, although a number of experts on local history were present at the opening reception — the last function presided over by Provost Billy Petrie before his well-earned retirement after 45 years in local government — none could solve a mystery.
Last Updated ( Friday, 25 May 2012 11:31 )Read more...
View this photo and over 1,650 more at the Heritage Trust Photo Gallery. Visit the gallery.
A new series of six Winter Open Meetings will begin on Wednesday September 30 at Helensburgh Tennis Club at 7.30pm.
Further meetings will be held on the last Wednesdays of October, November, January 2016, February and March.
The speakers programme will be published as soon as it is available.
Scottish Charity


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I will be spending thanksgiving in Newport this year. I will be traveling with my husband and our two teenage children. My son is 19 and daughter is 17.
I was thinking of staying at the Marriott with an ocean view room.
I would like to know of a restaurant that will offer the tradional Thanksgiving meal as well as some non-traditional options.
Also, we will be arriving Wednesday and leaving Friday evening, can anyone recommend some things to do. Will the mansions be open?
What is Newport like over the Thanksgiving holiday?


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|Reviews for Shift
| Revamp chapter 83 . 4/23/2013
The battle is intensifying, and Haruo and Yuki seem to be in a predicament. I wonder what will happen now that Haruo's animal has been beaten.
| Revamp chapter 82 . 4/23/2013
I was correct on Katsu's power of wind. I also like the blade power of his lackey. I act_ally have a character with a similar power in Capricious Infection. He can summon blades not make things into blades.
Haruo's power interests me. It seems like a type of beast summoning power. I had a feeling he would end up with a power, I was just wondering which one.
| Revamp chapter 81 . 4/23/2013
I wonder if Katsu has a wind power that makes him create what manga refers to as cyclone or wind cuts. That is my guess. It looks like Yuki will have to face another elementa user.
| Revamp chapter 80 . 4/23/2013
You continue to deliever the emotion and action in this chapter and Yuki's plan was perfect. Haruo is facing his past well, despite being sent into a wall. I'm glad the teacher has been freed and I anticipate the next chapter.
| Revamp chapter 79 . 4/23/2013
Things are really escalating now. I hope that Haruo is able to save his kind teacher.
| Revamp chapter 78 . 4/22/2013
This chapter added to Haruo's depth with Katsu and gave clarification to the earlier events. I like the depth of thier rivalry and I wonder what will happen next between them. Umfortunately, that will have to wait because my phone is dying.
| Revamp chapter 77 . 4/22/2013
The interactions between Haruo and Asanuma were touching and I love the ositive message this chapter conveys both with Yuki and Asanuma. This is another favorite chapter of mine.
| Revamp chapter 76 . 4/22/2013
This was.a nice look into Haruo's character. I've always wanted to see if there was more to him than what he appeared, since until now he's been in the background.
| Revamp chapter 75 . 4/22/2013
I like the developed power Yori got. It seems like all of the main characters have some sort of power. This chapter was dramatic and touching with a bit of humor at the end. I like chapters like this. They always develop characterization that other situations can't.
| Revamp chapter 74 . 4/22/2013
This chapter was very sad. I feel so bad for Yori and Yumi. I hope that she doesn't die. She was one of my favorite characters.
| Revamp chapter 73 . 4/22/2013
I wonder what Yumi is looking for that means so much to her. I also like the ironic humor at the end of this chapter. I wonder how they'll get themselves out of this situation.
| Revamp chapter 72 . 4/22/2013
I like the deep look into Ayumi's past, as well as her real name coming out. Her loyalty to the old king and her pain was expressed very well. My heart went out to her.
I like the contrasting views of Demosthenes and Eudokia and thier system of beliefs.
| Revamp chapter 71 . 4/22/2013
I'm glaf to see that Yuki is back. It's interesting to know that he can disguise himself as well. While I still perfer him with Saki, I like the touching moment between them and thier relation through loss.
| Revamp chapter 70 . 4/22/2013
The failed mission was a nice add to the depth of Chiharu's power. I have to wonder about her new power and what it is, though I have my theories.
| Revamp chapter 69 . 4/22/2013
This chapter was action packed. I loved the feelin6 it gave and Tomasu is still that guy I expect to turn on Chiharu any minute.


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One of the songs in this episode was sung not only by Rick but by Miss Tickle and Bronco as well. In real life, Lola Fisher, the voice of Miss Tickle, is also an accomplished singer. She requested permission to sing at least once on the show.
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We specialize in luxury and muscle cars; Buick, Cadillac, Lincoln, Mercury, Oldsmobiles and other luxury brands are our area of expertise. Our consignment selection has expanded to include all aspects of the collector car market including muscle cars, hot rods and exotics. We can also locate other specialty cars as your taste dictates. Our cars are pristine, original cars with low mileage or cars restored to original condition. Make sure to visit us at our new location!
Just arrived, a very nice example of the sought after Nova restored into a big block, Prostreet beast. Full roll cage, tubbed rear end and... More


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57 year old woman | Baton Rouge, LA, USA | Seeking men 49-61 within 200 miles
Active within 24 hours
Every day I wake up with an intention to experience joy.
I believe that life has so many gifts to offer if we are only paying attention. My beautiful daughter is without question the greatest gift in my life and I am most grateful for her and for the joy she has brought me. I believe that life is truly an adventure that we embark on to find ourselves. I see beauty in so many things and find wonder in everything I encounter along the way. I am a person who has experienced much and who seeks to live a life filled with joy and purpose in everything I do. I want to travel the world and see all that I don't encounter in my daily life and know what different cultures and people experience in their lives as I believe we are all connected. I love to run and be outdoors and connect with nature. Health and fitness are important to me and I live my life from a place of wellness as I believe that a healthy body equals a sound mind. I like to seek out adventure wherever I am and find that I am happy just going with the natural rhythms of life. I love music and art and great conversation with people who feel the same. I am well read and enjoy nothing more than a good book to keep me occupied at times. I would like to meet a person who is interested in exploring life and all the opportunities that are presented to us every single day. My ideal match is someone who is happy and able to see the positive in life and live from that place.
Coffee and conversation , Cooking , Dining out , Gardening/Landscaping , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Shopping/Antiques , Travel/Sightseeing , Volunteering , Wine tasting
Cycling, Running, Swimming, Walking / Hiking, Weights / Machines
I exercise 5 or more times per week.
I have Cats
I like Dogs, Horses
I have a beautiful cat who is 15 years old and definitely a goddess!
Middle of the Road
I really enjoy going to the ocean and to the mountains. Really anywhere that is scenic and interesting. I love all of Europe and want to travel to Asia and the Pacific Islands as well as South America and the Middle East.
I love all music- especially rock and classical with some alternative and new age thrown in. I am a very good cook and love to experiment with ethnic cuisines. I love art and beauty and slowing down to enjoy what is around me.
I love to run, hike and work out at the gym. I am a voracious reader- mainly non-fiction. My goal is to travel the globe but I make do now with trips to New Orleans and places like Austin that you can do in a long weekend.
Wishes Fulfilled by Wayne Dwyer. The Essential Rumi
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'4" (162cms)
|5'10" (177cms) to 6'4" (193cms)
|Body type:
|Athletic and toned
|Athletic and toned
|No preference
|Auburn / Red
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker
|Other profession
|No preference
|$50,001 to $75,000
|No preference
|Widow / Widower
|No preference
|Have kids:
|Yes, and they sometimes live at home (1)
|Yes, and they live at home
|Wants kids:
|No, but it's OK if my partner has kids
|No, but it's OK if my partner has kids
|White / Caucasian
|White / Caucasian
|Spiritual but not religious
|Spiritual but not religious
I am of the belief that we are all equal and that it does not matter what religion you belong to- belief is in the heart and not what is outside of us- we are all climibing up the same mountain usiing different paths.
|No preference
|Some college
|No preference


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Susan Oxnevad
onto 21st Century Research and Information Fluency
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Kevin Akita's curator insight, December 26, 2013 2:16 PM
Love the idea that digital citizenship is part of the continuum of information and tech literacy.
Lee Hall's curator insight, March 4, 2014 10:48 AM
They have quite a few already made images covered with hot spots of information or you and your students can make their own.
Lee Hall's curator insight, February 17, 2014 9:49 AM
Students love the web based version and I think they will like the app too.


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1999 Mercedes-Benz ML430 Q&A
1999 Mercedes-Benz ML430 Question: I installed a hitch on this truck and found the rear frame members are so rusted
And holy that I would be afraid to use a bike rack, so I removed the hitch! Is this common and would MB stand up for that? - Sottler
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|This user's favourite subject is History.
|One of this user's favourite subjects is Humanities.
|This user had graduated from Junior College/Centralised Institute with a GCE A-Level Certificate.
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Atlantic Ocean
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| Transclusions |-
Thomas Benjamin Maxwell Evans (born 18 March 1984 in Shoreham-by-Sea, England) is a English computer game editor/reviewer who supports Blackburn Rovers. He begun supporting Blackburn Rovers in the late eightees when he was introduced to the world of football by his brothers Gary and Matthew. He has supported the club ever since.
He made his Blackburn supporting debut in 1996-1997 Premier League season in Blackburn Rovers 2-0 defeat to Southampton F.C. at The Dell. His favourate game however is the 2000-2001 old 1st Division game at Loftus Road home to QPR in which Blackburn Rovers handed out a lesson to the aforementioned QPR in a 1-3 spanking in which David Dunn, Matt Jansen and Eyal Berkovic got on the scoresheet for Rovers.
He is now in regular attendance to as many games as he can watch. Including games against Chelsea, Portsmouth and is hoping to watch some Rovers games vs Arsenal in the coming seasons.
He also follows his local team Brighton & Hove Albion to a lesser degree, and also follows Hertha Berlin since a trip to Germany's capital in 2005.
Thomas suffers from Charcot–Marie–Tooth disease otherwise known as Peroneal Muscular Atrophy and has suffered from the condition since birth. He tries to help people with similar aflictions and is part of many charities that persue support and treatment for the disease.
As a member of the Wikipedia community for many years, he can be mainly found updating the Blackburn Rovers page and season pages. Although he tries to assist in keeping other pages up to date, accurate and removing page vandalism which is unfortunately a daily occurance on this website.
Articles I created[edit]
External links[edit]


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Channing Tatum: I worry about Justin Bieber
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Channing Tatum's paternal instincts are already kicking in and he only just welcomed his baby girl, Everly, into the world on May 31. The "Magic Mike" man tells Vanity Fair magazine's July issue that he has some concerns about Justin Bieber.
"I worry about Bieber, man. That kid's wildly talented," Channing, 33, said of the 19-year-old heartthrob. "I hope he doesn't fall down into the usual ways of young kids because it's so hard for someone to be responsible when they're not asked to be."
RELATED: You named your kid what?!
Prior to him and his wife, Jenna Dewan-Tatum, 32, becoming parents, the actor was already talking strategy on how he wanted to raise his child. "I'm just going to be a good friend to my kid," People's Sexiest Man Alive told the publication. "One thing I definitely want to change is that whole 'I don't want you to make the same mistakes' mentality. My dad didn't have much money growing up; he didn't have much of an education. He forced that on me, and I didn't want it."
Tatum added that he plans to take on parenting one day at a time. "I don't think you can prepare. It's a bit of a freestyle," he told Vanity Fair contributing editor Rich Cohen. "I don't know anyone who did have perfect parents. It's provided me with lessons I'll try to improve upon when I'm up to bat."
RELATED PICS: Hollywood's cutest kids
At the time of his interview with VF, neither Tatum nor his wife knew the sex of their baby, but as we know now, the actor guessed right! "My wife thinks boy. I think girl," he revealed.
What do you think of Tatum's views on fatherhood?
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Ajinkya Rahane said on Monday he had his own ideas for the cricket team and would back his instincts as the ODI captain during India's tour of Zimbabwe later this month.
India's leg-spin bowler Karn Sharma has been ruled out of an upcoming ODI tour of Zimbabwe due to a finger injury.
The all-rounder has been released on bail and will face a court hearing on July 21 after he returned a blood alcohol sample reading of approximately twice the United Kingdom's legal limit which is 100 micrograms of alcohol in 100 millilitres of breath.
Injury-plagued Australian paceman Ryan Harris on Saturday announced his retirement from all forms of cricket effective immediately, dealing a major setback to his team's defence of the Ashes starting in England next week.
New Zealand captain Brendon McCullum's explosive hitting saw him set a new record in the English T20 Blast competition on Friday with a blistering 158 not out off 64 balls for his county Warwickshire.
Indian women were handed a second consecutive loss by New Zealand in Bengaluru on Friday as the hosts now trail 2-1 in the five-match ODI series.
Modi had alleged that two leading Indian cricketers and a West Indian player had been bribed by an Indian real estate tycoon, who is also a bookmaker.
For the first time, an Indian Premier League team is on the verge of changing hands. JSW Steel chairman, Sajjan Jindal, confirmed on Wednesday that his group is acquiring an IPL side without naming it amid speculation that it could be Royal Challengers Bangalore, owned by liquor baron Vijay Mallya.
Maxwell was representing reigning county champions Yorkshire in a charity match against local village club Bardsley when he reeled in the remarkable catch without dropping what appears to be a Cornetto, though the identity of the ice cream in question remains unknown.
The Supreme Court took note of the BCCI's functioning and is trying to correct the wrongs by having appointed a three-member committee under the former Chief Justice of India, Justice LM Lodha, to suggest ways and means to ensure offences are not repeated.
Ajinkya Rahane admits he was stunned to be named India captain for their upcoming Zimbabwe series, after being dropped just a week earlier, and while he plans to draw inspiration from past skippers he also wants to make his own mark on the team.
The justice RM Lodha committee appointed by the Supreme Court as part of the investigations in the wake of 2013 IPL spot-fixing, will take more time to submit its full report.
Chief selector Sandeep Patil and his four fellow selectors have sent a firm message to ODI skipper MS Dhoni and Test captain Virat Kohli for controversial decisions taken during the Bangladesh tour.
Showing disrespect towards the Indian cricket team, Bangladeshi newspaper 'Prothom Alo' has produced a spoof 'cutter' advertisement, in which several Indian cricketers are seen standing with their heads half-shaven.
Barely a week ago ODI skipper MS Dhoni made a harsh assessment of Ajinkya Rahane and axed him from the playing eleven during the recent disastrous Bangladesh series. On Monday, the 27-year-old was back - as the captain of the Indian team that will tour Zimbabwe.


text: We came back after last year's vacation. Simply because we spent perfect holidays 12 months ago. And it was very nice again ! Staff still almost the same (which is a good sign), very, very friendly, food tasty and with the 3 'a la card' restaurants enough options to enjoy something else than the buffet. The close-by beach and swimming... More


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Does the Affordable Care Act Cover the Uninsured?
Drew Altman, in The Wall Street Journal's Think Tank, discusses what a new Foundation survey finds about one of the biggest questions about the Affordable Care Act: whether it covers the uninsured.
Trending on kff Medicare & Medicaid at 50 Individual Market Medicaid Expansion
Drew Altman, in The Wall Street Journal's Think Tank, discusses what a new Foundation survey finds about one of the biggest questions about the Affordable Care Act: whether it covers the uninsured.
People in ACA-Compliant Plans Are Somewhat More Likely To Say They Are in Fair or Poor Health Than Those in Non-Compliant Plans People Who Switched Plans Due to Cancellation Notices or Other Reasons Are As Likely To Say Their Premiums Went Down As Went Up Overall About As Many People…
One of the most politically polarizing elements of the Affordable Care Act (ACA) is the law's requirement that new private health insurance plans cover prescription contraceptives and services, including all methods approved by the Food and Drug Administration. The rule currently provides an exemption for houses of worship and an…
As many employers begin to expand their wellness programs under new guidelines set forth by the Affordable Care Act (ACA), the latest Kaiser Health Tracking Poll finds workers oppose programs that make them pay higher premiums if they fail to participate or meet specific health goals. Overall public opinion of the ACA remains about the same as it has for the last several months, with a somewhat higher share of the public continuing to express an unfavorable view of the law (45%) than a favorable one (39%).
This month's Health Policy News Index finds more than six in 10 say they followed
news about long waiting lists for those seeking care at Veterans Affairs (VA) medical facilities closely.
That makes the VA story the most closely followed health story in the first half of 2014, with slightly
more people following it than followed several ACA enrollment stories earlier this year.
Drew Altman, in The Wall Street Journal's Think Tank, on what we know about what women think of the policy issue at the core of the Hobby Lobby Supreme Court case.
In his latest column for The Wall Street Journal's Think Tank, Drew Altman explores some early indicators that the political waters may be calming for the Affordable Care Act.
This report profiles the uninsured in Texas, their access to care and coverage, and how the ACA could impact them. It compares the circumstances that the uninsured in Texas encounter to those that the insured encounter. This report relies upon the Kaiser Survey of Low-Income Americans and the ACA.
The March Kaiser Health Tracking Poll finds that the gap between unfavorable and favorable opinions of the ACA narrowed this month among the public and the uninsured, and more want Congress to improve the law than replace it. The survey also finds that six in ten of the uninsured are unaware of the March 31 deadline to sign up for coverage, and half say they plan to remain uninsured.
The Kaiser Health Policy News Index is designed to help journalists and policymakers understand which health policy-related news stories Americans are paying attention to, and what the public understands about health policy issues covered in the news. This month's Index finds that the public followed the missing Malaysia Airlines flight and the conflict between Ukraine and Russia more closely than news about ACA enrollment. Additionally, many Americans remain unaware of the status of Medicaid expansion in their own states.


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Outdoor Recreation
Sports retailers fall short on social engagementJune 01, 2012
As plans for summer weekend getaways are set in motion, people are gearing up for the great outdoors — and we're rating the retailers.
Amazon.com launches outdoor store onlineJuly 14, 2009
Amazon.com has launched a destination shopping site for outdoor recreation items at amazon.com/outdoors. To support the launch, Amazon is offering a free National Parks and Federal Recreational Lands pass to virtual store visitors who make a qualifying purchase of $299 or more. Amazon will also offer customers a chance to pre-order a DVD set of the forthcoming Ken Burns PBS documentary, "The National Parks — America's Best Idea."
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Dinner at the, on premise, Safari Club was delicious with excellent service. I have stayed at this Days Inn on many occasions to enjoy the hot springs at the Days Inn and other spas in the park.
We appreciated that the Days Inn was pet-friendly. Location is super convenient to the Hot Springs State Park and pools. Room was clean. Hot tub and spa/workout facility were great amenities to take advantage of. Love the pictures and mounts, lots to talk about with the kids! Staff was friendly.
The hotel decor is a bit dated. Food in the restaurant was fine, our steaks weren't that great, but the homemade meatloaf and mashed potatoes were really good.
The room was amazing! It felt like a 4 star room! Staff was also very friendly and helpful.
Breakfast and common areas were not great, but matched the star level. Also, the mats in the public areas don't stick to the floor very well causing them to slip when people step on them.
The staff went above and beyond when our party required the use of the lobby. The rooms were comfy and clean.
The water temperature varied widely when you stay in the rooms left of the lobby, regardless of time of day/night. Per one staff member, the water heater is on the right. Why not use the onsite hot spring to heat the water?
great beds and interior decor,front lobby furniture very comfortable,plenty of parking,well lit parking area.thermopolis hot springs park very close and excellent fishing opportunities abound, very friendly town with yellowstone just a couple hours away
housekeeping needs to do a better job,food quality needs raised,maintence of pool area.
The bed was comfortable
I didn't like the cooling system on how I think blows
Room was filthy, there were spiders and other bugs all over the bathroom. You could barely open the door to the room and it was just not a pleasant experience. I will not be staying here again!
Spacious room, very clean.
Too close to the highway.
Price, parking
Noise, bed had no space under edges, we kept hitting our toes on the pedestal.
Here's why:
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Written on: 10/03/2013 by FVWATSON (1 review written)
WE have found with use, the symbols and temperature indicators wear off on the front panel of our oven Mod No FID20XIMK2 Ser No 707120110
Enquiries made to Indesit have been useless,They said that they used to do a touch-up kit but this is now discontinued.
This defect does not make for easy cooking in an otherwise good cooker.
Frederick V Watson
" No goods received little communication " Read More
" No real heat from stove " Read More
" DO NOT BUY " Read More
" Glass cooktop exploded " Read More
" Lacanche Macon is a great cooker " Read More
Written by Geodesic


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What's new about the Intel® Xeon® Processor E5-2600 (formerly codenamed Sandy Bridge-EP on the Romley Platform)? Learn about new features, and read explanations of the latest technologies in these processors.
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For nearly 50 years, Parks & Recreation magazine has helped park professionals serve the public. Through its pursuit of key issues, trends, and personalities, the magazine advances American parks, recreation, and conservation efforts.
The Personal Benefits of Parks
Majority "Baseball Rule" Limits Spectator Liability
5 Key Trends in Parks and Public Health
The New Demographics
Public Private Partnerships
We have parks and programs that reach the people. We are a trusted voice on issues related to natural resources. By taking a more proactive role in en..
Continue Reading
Limiting screen time in your park and recreation summer and out-of-school time programs can be a challenge, especially on inclement-weather-days. What..
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Extra! Extra! Read all about it! This week NRPA was named to The Washington Post Top Workplaces 2015. Being awarded the title of Top Workplace means e..
Continue Reading
Parks & Recreation, the monthly magazine of the National Recreation & Park Association in Ashburn, Virginia. NRPA has 50,000 members and is dedicated to advancing parks, recreation, and environmental conservation efforts that enhance the quality of life for all people.
Browse our writers' guidelines.
Gina Mullins-Cohen joined NRPA in March 2013 and serves as vice president of marketing, communications and publications. Mullins-Cohen brings with her more than 17 years of communication and publication management experience. She has launched and managed numerous publications in several diverse industries, as well as owned and directed a media-communications firm. As founder of Eclipse Media Partners LLC, she was able to work with and report on the achievements within park systems in Southern California. Prior to Eclipse Media Partners, Mullins-Cohen held the post of executive vice president of Electronic Retailing Association (ERA), where she oversaw the communications, publishing and education divisions. Her consumer publication, Edible Orange County, was the recipient of the James Beard Foundation Award for Best Publication in 2011. Her work in B2B publishing and communications has been the recipient of four Maggie Awards from the Western Publishing Association. Mullins-Cohen lives in Lansdowne, Virginia.
Dana Storm, senior manager of advertising sales, joined the Parks & Recreation magazine staff in June 2013. Her most recent stints include advertising manager for a weekly newspaper in Fairfax County and director of account services for a local branding firm. Storm currently manages print advertising and digital sales for NRPA's magazine, website, monthly newsletter, Field Guide and weekly email service. She graduated from Virginia Tech with a B.A. in elementary education and currently resides in Berryville, Virginia.
Samantha Bartram, executive editor, joined the magazine staff in December 2013 following a seven-year stint in the local newspaper industry as a senior writer with Northern Virginia Media Services. Bartram's work focuses on several areas of the magazine, including writing, editing, design and web. In addition to her work at Parks & Recreation magazine, Bartram works as a freelance writer for Vetstreet.com. She holds a B.A. in musical theater from Wittenberg University and lives in Leesburg, Virginia.
If you are interested in having Parks & Recreation feature one of your company's products, please send a hi-res image and description of no more than 100 words to Samantha Bartram at NRPA.
22377 Belmont Ridge Road Ashburn, VA 20148-4501 800.626.NRPA (6772)
© 1997-


text:
Air Modeling Companies in Thailand
Category: Air & Climate ×
Subcategory: Air Modeling ×
Location: Asia & Middle East ×
Location: Thailand ×
based in Orsay, FRANCE
LEOSPHERE, founded in 2004, and its subsidiary Avent Lidar Technology are world leaders in ground-based and nacelle-mounted LIDAR (Light Dectection And Ranging) for atmospheric observation. The companies design, develop, manufacture, sell and service new turnkey remote-sensing instruments allowing wind measurement and aerosol characterization. LEOSPHERE has deployed ...
Environmental & Geo Spatial Solutions (EGSS)
based in Chennai, INDIA
Environmental & Geo Spatial Solutions (EGSS) is an reputed Environmental and GIS Consulting Company. The newly opened company comprises unique minded, well qualified and well experienced personnel in India and Middle East. The company caters to sophisticated clients in environmental, ground water, Survey and GIS projects. EGSS personnel have successfully conducted several ...
Weather Analytics
based in Bethesda, MARYLAND (USA)
All building modeling and simulation systems require local weather history and climate data to complete their analysis. The better the climate data, the more complete the history, and the more local to the site of interest – the more accurate the results. Whether you are an architect, engineer, construction manager or utilities manager, Weather Analytics is able to help ...
Baltec Australia
based in Stafford, AUSTRALIA
Baltec Australia is an air pollution control company specialising in electrostatic precipitators and their application in industrial processes to control particulate emissions. We offer a wide variety of professional services and quality products to meet the gas cleaning needs of our clients. These services include Project Management and Supervision, Technical Training ...
Oris Solutions / BEE-Line Software
based in Austin, TEXAS (USA)
Bowman Environmental & BEE-Line Software became Oris Solutions, LLC in 2007.Bowman Environmental was founded in 1982 by J. Thomas Bowman. From there Dr. Bowman developed the Bee-Line Software products by rewriting the EPA mainframe guideline for air dispersion models and several emergency release models for use on microcomputers.BEE-Line Software has been providing ...
Envac AB
based in Stockholm, SWEDEN
Envac is the global market leader in automated waste collection. We develop and sell underground network systems for transportation of municipal and commercial waste. With the Envac solution the collection and transportation of waste is fully automated, safe and environmentally advantageous. The installation of an Envac system leads to a drastic reduction of road ...
Mierij Meteo Nederland
based in De Bilt, NETHERLANDS
Mierij Meteo systems was founded in 1982 and delivers solutions for projects where meteorological information is essential. Mierij Meteo is an innovating company that keeps innovating their meteorological sensors and systems with the goal to improve the quality of your measurements, to improve your saftey, to reduce your cost of ownership, to improve reliability and to ...
Meteorological Solutions Inc. (MSI)
based in Salt Lake City, UTAH (USA)
Meteorological Solutions Inc. (MSI) is an air quality and meteorological consulting company with a strong emphasis on near-field dispersion modeling, far-field dispersion modeling, and air permitting. We can provide complete meteorological and air quality monitoring services including initial site selection and permitting, monitoring systems integration and installation, ...
Wölfel Meßsysteme · Software GmbH Co.KG
based in Höchberg, GERMANY
Wölfel is one of the leading suppliers of Noise Prediction & Noise Mapping Software to consulting engineers, public authorities, universities and industries world-wide. Other products include complete hardware/software systems for room acoustics measurements and software for assessment and rating of noise levels with quality-assured measurement of percentile levels. The ...
Dillon Consulting Limited
based in Calgary, ALBERTA (CANADA)
Dillion is an international Canadian owned professional consulting, planning, engineering, environmental sciences, and management consultancy firm. Their environmental services include, contaminant management, site and facility audits, remediation and rehabilitation, hydrogeology, air quality, solid and hazardous waste, terrestrial and aquatic habits, wetlands, watersheds ...


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Mine does.
It hadn't previously occurred to me that this might be an unusual thing, because I know that it is public information anyhow. But in a conversation with a friend from another city once, she expressed surprise at the level of detail that is printed in my local paper.
The reason this happened to be on my mind today?
In today's paper, the cause of death for one of the men was listed as "Accidental, hanging by the neck due to auto-erotic asphyxia."
From now on, when anyone Googles this man's name and city, this result will pop up.
I really don't know what the best protocol for death records should be. Death records are public information, of course, but I'm not entirely sure that the information needs to be available on the internet at that level of detail either.
Perhaps merely publishing "accidental" would be sufficient in this case, without the addition of auto-erotic asphyxia?
This was just one example that happened in today's paper - there have been others in the past that seemed to be overly detailed too.
(If it makes a difference, this paper is not the legal paper of record in our city. It's the largest commercial paper, but not the official paper for legal notices.)


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I am printing to pdf in Windows 7. Lately, my documents rotate when printing. They are in landscape format before printing, but the printed document rotates 90 degrees. How do I prevent this?
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text:
Is this the winter of our content?
Relevant offers
As the nation marked the shortest day of the year yesterday, some towns and cities have experienced their warmest start to winter on record.
Niwa forecaster Christopher Brandolino said that 20 days into winter, Palmerston North and Whanganui residents had enjoyed their warmest average temperatures for June since records began, in 1928 and 1937 respectively.
Masterton was also going through one of the mildest starts to winter on record, Brandolino said, as was Whangarei.
The main centres were also having a better-than-average winter so far, with the average Auckland temperature, measured at Whenuapai, coming in as the third-warmest since records began in 1945.
Although this month's storm cut power to some Aucklanders for about a week and uprooted trees, it also brought in some warm air, Brandolino said. "It was windy and wet but it wasn't a cold rain."
Wellington's average temperature so far this month was 2.1 degrees above normal, at 11.8 degrees. Christchurch's was 1.2 degrees above the normal average for June at 8.1 degrees.
Brandolino said the lack of southerly winds caused the unseasonal warmth.
The top half of the country had had a wetter than normal start to winter but conditions elsewhere were quite dry.
Looking ahead, the warmer-than-average temperatures were likely to continue, Brandolino said.
However, the east coast of the North Island and the top of the South Island should expect above-average rainfall for the rest of the winter as warm winds come in from the east. Rainfall should be about average for the rest of the country.
Snowfall predictions were difficult but with a warmer winter ahead, ski resorts might have to make their own snow unless more frequent and intense southerlies arrived, Brandolino said.
- Sunday Star Times
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Apr 03 - Homily: Peter & Judas
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Uploaded by AirMaria on Apr 3, 2012
When Our Lord tells Judas toĀdepart and carry out his deed, he is still working for his salvation. The Lord does all that he can so that He would draw us to himself - so that He would save us. We must discern what Our Lord is calling us to do. Ave Maria! Mass: Ordinary Form - Tuesday Holy Week Readings: 1st Reading: Isaiah 49:1-6 Responsorial Psalm: 71:1-2, 3-4, 5-6, 15, 17 Gospel: John 13:21-33, 36-38 Audio (MP3) To Download Audio go to http://airmaria.com?p=27773
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Dr Barry Yates, manager of Rye Harbour Nature Reserve, was praised for being able to capture the social behaviour of the sea birds.
He said that just taking the picture was "thrilling in itself" but winning a competition was "icing on the cake".
His pictures will be on display in an exhibition in Rye next May.
Dr Yates won the category for Best Digiscoping - a photographic technique which uses a digital camera through a telescope - in the Bird Photographer of the Year competition run by British Birds magazine.
Councillor Matthew Lock, of East Sussex County Council, said Dr Yates's work provided "a wonderful record of the huge variety of wildlife at Rye Harbour Nature Reserve".
The winning picture showed a young Mediterranean Gull being fed.
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|Viewing Single Post From: Newcomers headed to Y&R
|Oct 15 2012, 10:28 PM
:boobs: :boobs: L&D...I'm about to change my position from NEVER watching Y&R to trying to whore :boobs: myself out to these 2 men!!! :wine: DAMN!!! :thumbsup: :thumbsup:
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text: It isn't that this is a bad hotel because it was very clean and the staff was beyond nice and personal. It was just that it was so pricey for such an average room. Maybe it is because I live in Las Vegas and they don't charge for you to park your car here. But $31 a night to park our car in their garage when the rooms are already $200 a night is just insane. We were blessed to have someone help us with this room because we take monthly trips to Cedar-Sanai hospital in L.A. but we wouldn't ask to stay here again. However, staff (like I said) was fantastic, every single one of them. Also, the fitness room was nice, but the pool closes at 6 or 7 because it is in the middle of the restaurant. Also, they had nightly parties outside in the middle of the rooms and they got loud because they were in such inclosed spaces. It would be nice if they at least offered free coffee 24/7 for their guest.