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Tesla Quartet Places at Multiple Competitions
May 14, 2012
The Tesla Quartet, graduate string quartet-in-residence at the CU College of Music, has earned the Gold Medal in the Senior Strings Division of the illustrious Fischoff Chamber Music competition. After several rounds of rigorous competition, the Tesla Quartet emerged with the gold medal in the senior strings division along with a $3,000 cash prize. In addition to the prize money, the Tesla Quartet will participate in a tour of the midwestern United States in October.
Keane Southard (MM 2011) Fulbright in Brazil
May 1, 2012
Keane Southard (MM 2011, composition) has been awarded a Fulbright U.S. Student grant to spend nine months next year pursuing research in Brazil.
CU Chamber Ensembles to Participate in Fischoff Competition
April 17, 2012
Three chamber ensembles, all of differing instrumentation, have been accepted to compete with top musicians from across the country in the Fischoff Chamber Music Competition. Based on audition materials and applications, the Zenobia Quintet, the Flatirons Brass Quintet and the Tesla Quartet have all been accepted into this illustrious competition.
ENTREPRENEURIAL UPBEAT: Vol. 5, No. 9
April 16, 2012
THIS WEEK ON ENTREPRENEURSHIP WEDNESDAYS: MANAGING YOUR PERSONAL FINANCES with guest DENNIS PAUL from Elevations Credit Union How many of you have student loans? Credit card balances? Other financial responsibilities? How many of you are already saving for retirement or paying your own health insurance? Do you know your credit score and why it's so
ENTREPRENEURIAL UPBEAT: Vol. 5, No. 8
April 16, 2012
THIS WEEK ON ENTREPRENEURSHIP WEDNESDAYS: BUILDING A "PORTFOLIO CAREER" with special guest artist, flutist LINDSEY GOODMAN What's a portfolio career? It's what many (if not most) music students say they aspire to have: a career made up of teaching, an orchestral job, and chamber/solo performing. Learn what it takes to build such a career from
Takács Quartet Inducted into Gramophone Hall of Fame
April 12, 2012
Gramophone, the world's authority on classical music, in preparation for its 90th birthday celebration, has selected 50 names to be the first inductees into The Gramophone Hall of Fame. Among these 50 names are only two ensembles, one of them being CU Boulder's very own Takács Quartet.
Patrick Mason to receive 2012 Hazel Barnes Prize
April 10, 2012
Patrick Mason, a professor of voice at the University of Colorado Boulder's College of Music, has been selected to receive the 2012 Hazel Barnes Prize. The prize is the highest faculty recognition for teaching and research awarded by the university.
Mason will receive an engraved university medal and $20,000, the largest single faculty award funded by CU-Boulder. He will be recognized at spring commencement on May 11 and at a reception in his honor in the fall.
Composition Faculty Daniel Kellogg Wins Aaron Copland Award
April 5, 2012
Composition faculty Daniel Kellogg has been awarded a coveted Aaron Copland Award that includes a residency at Aaron Copland's National Historic Landmark house in New York's lower Hudson Valley. During this residency, Professor Kellogg will continue his exemplary composition work.
Alumni Anasazi String Quartet win MTNA Chamber Music Competition
March 29, 2012
The Anasazi String Quartet (ASQ) won 1st Prize in the 2012 MTNA National Chamber Music Competition. The quartet, praised by audiences for their passionate and engaging performances, has been playing together since the fall of 2009. Founded at the University of Colorado at Boulder, ASQ pursued studies with the school's string faculty: Lina Bahn, Judith Glyde, Erika Eckert, and the Takács Quartet.
Megan Marino MM 2008 wins 3rd prize in 2012 Lotte Lenya Competition
March 27, 2012
CU-Boulder Music alumna Megan Marino (MM 2008, vocal performance) won third prize in the 2012 Lotte Lenya Competition on April 21, 2012, at the Eastman School of Music in Rochester, New York. Three-time Tony Award nominee Rebecca Luker, Broadway and Encores! music director Rob Berman, and Rodgers & Hammerstein Organization President and American Theater Wing Chairman of the Board Theodore S. Chapin served as judges.


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You can now invite anyone to meet at your favorite Starbucks.
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29 year old woman | Cincinnati, OH, USA | Seeking men 27-39 within 50 miles
The earth without art is just eh
I like weird. The weirder you are the more I'll like you. I like artistic and musical people. Hard working and positive people who enjoy life's ride make the world a better place. I paint and draw, enjoy flea markets and fresh markets, hiking and drink by campfires. I like beer and whiskey. I'm the assistant to the IT Director at Disabled American Veterans National Headquarters. I also handle all of the ordering and finances for the department. It's a great nonprofit doing great things. I am lucky to enjoy going to work every day. "Everyone discusses [my art] and pretends to understand, as if it were necessary to understand, when it is simply necessary to love." Claude Monet
Alumni connections , Camping , Coffee and conversation , Business networking , Cooking , Dining out , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Playing cards , Playing sports , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Aerobics, Baseball, Basketball, Billiards / Pool, Bowling, Cycling, Dancing, Football, Other types of exercise, Swimming, Walking / Hiking, Yoga
I exercise 3-4 times per week.
I have Cats
I like Dogs, Fish, Horses
Dewey's Pizza, Molly Malone's, Neon's, Music Hall, Contemporary Art Museum, Cincinnati Art Museum, Thompson House, breweries, festivals, nature
University of Cincinnati, Cincinnati, OH
I like movies that scare people, not just horror but psychological and social. I'm a music whore. There is very little i dislike. I like to eat anything but squash and well done meat.
Didn't we cover this is "favorite Hot Spots" and "Favorite Things"???
I like fun and bizarre short stories. Haruki Murakami's "TV People" is by far one of the strangest stories I've read.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'10" (177cms)
|5'10" (177cms) to 6'11" (210cms)
|Body type:
|Slender, About average, Athletic and toned
|Black, Blue, Brown, Grey, Green, Hazel
|Light brown
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Salt and pepper, Silver, Dark blonde, Grey, Platinum
|No Way
|No Way, Occasionally
|Social Drinker
|Social Drinker, Moderately
|Administrative / Secretarial
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|$35,001 to $50,000
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|Never Married
|Never Married, Widow / Widower, Divorced
|Have kids:
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|Definitely, Someday, Not sure
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|Asian, Black / African descent, East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian, Other
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|Bachelors degree
|Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral

subset: commoncrawl


text:
Owner Reviews
Samsung Galaxy Note 3 (AT&T), BlackSM-N900AZKEATT
Rated 4.8 out of 5Â by 780 reviewers.
Rated 5 out of 5Â by dinoboy my favorite phone I enjoy this phone because I love the note aspect. I just wish the battery stayed charged longer. It takes great pictures. June 28, 2015
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1-4 of 780


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|"FGM is recognized internationally as a violation of the human rights of girls and women. It reflects deep-rooted inequality between the sexes, and constitutes an extreme form of discrimination against women. The practice violates a person's rights to health, security and physical integrity, the right to be free from torture and cruel, inhuman or degrading treatment, and the right to life when the procedure results in death." --World Health Organization
>> EGYPT: Enforce FGM law & properly investigate Soheir al-Batea's death [1]
>> KENYA: Protect girls by enforcing FGM and child marriage laws [2]
>> INDONESIA: End government legitimization of female genital mutilation (FGM) [3]
>> LIBERIA: Enact a law banning FGM and ensure that Ruth Berry Peal's case is swiftly concluded [4]
>> MALI: Call for the enactment of an anti-FGM law [5]
Female Genital Mutilation [6] (FGM) is a harmful traditional practice that involves the partial or total removal of the female genitalia. It is estimated that between 100 and 140 million girls and women around the world have undergone genital mutilation. FGM ranges from the partial or total removal of the clitoris (clitoridectomy), to the removal of the entire clitoris and the cutting of the labia minora (excision), to its most extreme form, the removal of all external genitalia and the stitching together of the two sides of the vulva (infibulation).
FGM is generally done without anaesthetic, and can have lifelong health consequences including chronic infection, severe pain during urination, menstruation, sexual intercourse, and childbirth, and psychological trauma. No one knows how many girls die from FGM.
Grassroots organizations in FGM practicing countries are working hard within their communities to eradicate this practice. Equality Now supports the work of grassroots groups to end FGM and in particular focuses on the enactment and effective implementation of legislation against FGM in relevant countries.
|Campaign for a Law Against FGM
in Mali 2009
21 October 2014 Remembering our friend and colleague, Efua Dorkenoo [8]
10 October 2014 The Girl Generation Launches [9]
23 July 2014 New Estimates on FGM in England and Wales by Equality Now and City University London [10]
12 May 2014 Equality Now works to end FGM in the US [11]
6 February 2014 Equality Now named to consortium leading a global campaign to end FGM/C [12]
5 February 2014 African Activist Declaration from Equality Now Workshop [13]
Other Equality Now initiatives to end FGM:
>> Eliminating FGM in the UK: The Way Forward [14]
>> Africa Rising, a documentary film produced by Equality Now about the grassroots movement to end FGM [15]
>> Campaign calling on the American Academy of Pediatrics (AAP) to revoke its 2010 policy statement on female genital mutilation [16]
For information about past and completed campaigns in this program area, please see the actions archive [17].
For additional resources on FGM, please click here [18].


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Global Shakespeares Asia Portal
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The MIT Summer Research Program (MSRP) began in 1986 as an institutional effort to address the issue of underrepresentation of African Americans, Mexican Americans, Native Americans, and Puerto Ricans in engineering and science in the U...
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The MIT International Science and Technology Initiatives—better known as MISTI—connects MIT students and faculty with research and innovation around the world. MIT's primary international program, MISTI is a pioneer in applied internatio...
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The 6.370 BattleCode programming competition is a unique challenge that combines battle strategy, software engineering and artificial intelligence. In short, the objective is to write the best player program for the computer game BattleC...
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Updated 1 month ago
Please enjoy this growing collection of instructional videos showcasing the history and technology of document security and letter writing. Many of the videos show how historic letter or documents were once folded and secured shut to fun...
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MIT's Campus Preview Weekend (CPW) is a chance for the admitted students of the Class of 2012 to experience what MIT is all about, live and in person – the campus, culture, and community. \n \nWe'll be adding videos all weekend and into ...
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text:
After twists and turns like a winding road, this season's Region 1-AA basketball tournament has apparently landed in Bluff City - probably.Comments
Science Hill gets a 374-mile round trip to Bradley Central.Comments
Kevin Harvick dominated a race he had to win to advance to the final round of NASCAR's playoffs, while Jeff Gordon was knocked out when Ryan Newman completed a last-lap pass.Comments
The Ravens have long relied on a strong running game and a suffocating defense to win, and that was precisely the formula Baltimore used to beat Tennessee.Comments
18-year-old rookie Chase Elliott became the youngest driver to win a title in any of NASCAR's three national series after Saturday night's Nationwide race.Comments
While Dobyns-Bennett football coach Graham Clark is known for starting off an interview with a joke, it was Science Hill coach Stacy Carter who was in a joking mood on Saturday morning. "Dobyns-Bennett? That's who we play next?," Carter jokingly asked.Comments
The East Tennessee State women's basketball team overcame a 30-point second-half deficit Saturday night to beat King University, 73-71, at Brooks Gym in a game that will be remembered for a long time by both teams.Comments
Malik McGue rushed 28 times for a career-best 280 yards and four touchdowns and passed for two TDs to help Science Hill outlast Bradley Central 59-47 in a Class 6A playoff game.Comments
Knox Catholic shut down Ethan Thomas and Elizabethton for a 24-17 victory in a Class 4A playoff game Friday night.Comments


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Killer Condom
|Killer Condom
(Kondom des Grauens)
|Directed by
|Martin Walz
|Produced by
|Erwin C. Dietrich
Ralph S. Dietrich
Harald Reichebner
|Written by
|Ralf König
Martin Walz
Mario Kramp
|Based on
|Kondom des Grauens / Bis auf die Knochen
by Ralf König
|Udo Samel
Peter Lohmeyer
Marc Richter
Leonard Lansink
Iris Berben
|Music by
|Emil Viklický
|Alexander Honisch
|Edited by
|Simone Klier
|Distributed by
|Troma Entertainment (USA)
Release dates
Running time
|107 minutes
|Germany / Switzerland
Killer Condom (original title Kondom des Grauens (English: Condom of Horror)) is a 1996 German horror comedy directed by Martin Walz. It is based on the comic book of the same name by Ralf König.
It was distributed in the United States by Troma Entertainment.
Tagline: The rubber that rubs YOU out!
Set in the seedy parts of New York City, Killer Condom follows gay Detective Luigi Mackeroni (Udo Samel), who has been hired to investigate a series of bizarre attacks at the Hotel Quickie in which male guests have all had their penises mysteriously bitten off. While at the crime scene, he enlists the services of a gigolo named Billy and invites him up to the crime room. Before the two men engage in sex, a carnivorous living condom interrupts them and bites off Mackeroni's right testicle.
Now on a personal vendetta, Mackeroni begins his lone quest to not only bring a stop to the rash of condom attacks, but also face his true feelings toward Billy the gigolo.
External links[edit]
See also[edit]
|This article about a comedy horror film is a stub. You can help Wikipedia by expanding it.
|This comics-related film article is a stub. You can help Wikipedia by expanding it.


text:
what a way to end a great season of comedy, also drop some exciting cliffhangers, well, the one i care most about, who's going to play Tammy I?
who can top Megan Mullally's fiesty Tammy II besides herself?
and leslie running for office, it's a high stake to take into next season, her relationship with Ben, how will it go?
"The Bubble"
Ron Swanson in swivel chair have me laugh so hard, then Leslie prep Ben for the meeting with her mom has some classic Leslie moments
also "Tell Mort I said, 'Your move.'"
"Li'l Sebastian"
the whole Li'l Sebastian memorial is so great, ending with Ron burning his eyebrows off, just hysterical funny
Tom and Jean-Ralphio's Entertainment 720, with Detlef Schrempf's reappearance
5000 Candles in the wind, i want a Mouse Rat CD too


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Yonder Mountain String Band Adds August Shows to Summer Tour
Indie bluegrass band Yonder Mountain String Band (or YMSB to their fans) have announced that they're adding a string of shows in August to their already packed summer touring schedule. The guys are currently playing shows throughout the Midwest till the end of June. They'll continue through July with performances in Nashville, Ohio, Michigan, Pittsburgh, upstate New York and New Hampshire. The August leg will start at Penn's Peak in Jim Thorpe, PA, on August 21. From there, it's on to Baltimore and then North Carolina, where they'll play Black Mountain on August 23, Charlotte on August 28 and Wilmington on August 28. They'll finish up the summer with two shows in Virginia — the NorVA in Norfolk on August 30 and the Jefferson Theater on August 31.
Formed in 1998, the Yonder Mountain String Band has become a dominant presence in the American bluegrass scene. They've released ten albums since 1999 (the majority of them on their own record label, Frog Pad Records), the last three of which have reached the top spot in the U.S. bluegrass charts. This current tour is the group's first since the departure of mandolin player and vocalist Jeff Austin in April.
Yonder Mountain String Band Tickets & Tour Dates
Hinterland Music Festival (2 Day Pass) with TV on the Radio, Edward Sharpe and the Magnetic Zeros, Brandi CarlileWaterworks Park – Des Moines, IA
Hinterland Music Festival (Saturday Pass) with Brandi Carlile, Old Crow Medicine Show, Justin Townes EarleWaterworks Park – Des Moines, IA


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As Auburn Spring Practice Passes Halfway Point, Malzahn Pleased
As Auburn's spring practice went past the halfway point with Saturday's scrimmage at Jordan-Hare Stadium, head coach Gus Malzahn said he was pleased...
Will Muschamp Bristles at Comment by Florida Gators Coach Jim McElwain
Auburn defensive coordinator -- and former Florida head coach -- Will Muschamp said he hasn't heard successor Jim McElwain's assessment that he left a barren offensive roster behind in Gainesville...
Check out These Concept Uniform Designs for Auburn
We've got college football on our minds, and while Auburn has some of the most iconic uniform designs in all of college football, we found ourselves wondering what else is possible ...
Will Muschamp Says He Likes Direction of Auburn Practices
AUBURN, Ala. -- New Auburn defensive coordinator Will Muschamp says he's pleased with the attitude of his players, and especially how quickly they're picking up his schemes.....
Ricardo Louis Feeling No Pressure to Put It All Together
Auburn Receiver Jason Smith 'Can Do Things Most Other People Can't Do'
Raashed Kennion Growing into Role on Auburn's Defense
AUBURN, Ala. -- Raashed Kennion, all 6-foot-6 of him, says he still getting accustomed to not playing basketball, but such is the life for a big defensive lineman who has his priorities in order...
Forget the QB Battle, Auburn QB Jeremy Johnson Will Be a Star
While quarterback battles rage in Tuscaloosa, Athens and Oxford, another—perhaps under-the-radar one—could be brewing at Auburn...
Jason Smith Transitioning to Wide Receiver
AUBURN -- Jason Smith's bid for the starting quarterback didn't even last until the first spring scrimmage.....
Auburn Comes out 'Sluggish' in First Post-Spring Break Practice
AUBURN, Ala. — After a week off for spring break, Auburn returned to the practice field Tuesday. Being back was the only positive Gus Malzahn could take from the Tigers' first session in 12 days...
Auburn Quarterbacks in 'Good Spot', Says Gus Malzahn
AUBURN, Ala. -- Gus Malzahn said his Auburn quarterbacks are in a "good spot" entering the second phase of spring practice.....
Auburn Cornerback Undergoes Surgery for Torn ACL
Auburn cornerback T.J. Davis tore his ACL in practice two weeks ago, underwent surgery and will miss the rest of the spring. .....
Auburn in Front for Quarterback Lowell Narcisse of Louisiana
Kamryn Pettway's Athleticism at H-Back Excites Auburn Coaches
Few who follow Auburn football were surprised when the Tigers tested Kamryn Pettway at H-back during Outback Bowl practices, then shifted the redshirt freshman to the position full-time this spring...
Will Muschamp: Tigers About to Reach Point Where Execution, Retention Graded
AUBURN, Ala. — This isn't Will Muschamp's first rodeo when it comes to installing a defensive philosophy.....
Who Will Be Auburn's Starting RB in 2015?
The SEC is full of intriguing position battles this spring, but one that might not be getting as much attention is taking place at Auburn where three, soon to be four, players are competing to become the next 1,000-yard rusher in Gus Malzahn's offense...
Be Like Kodi: Jonathan Wallace Wants Big Finish at Auburn
Auburn Quarterback Sean White Earning Praise in Second Year
Jeremy Johnson may be the overwhelming favorite to win the starting quarterback job come fall, but Sean White isn't just going to sit back and idle while Johnson continues to impress...
Carl Lawson: Fellow DL DaVonte Lambert 'Opened My Eyes' in 2014
AUBURN, Ala. — Hard as he tried, Carl Lawson wasn't able to get his left knee back to a level where doctors would clear him to play last season...
Jonathan Jones Gives Will Muschamp Cornerstone to Build Around in Secondary
Somehow, in the middle of all the defensive chaos that plagued the secondary last season, Auburn unearthed a star.....
Healthy Auburn Defensive Line Could Result in Big Numbers for Veteran Tackle
Auburn Football: Tigers Expect Offense to Keep Humming Along in 2015
AUBURN, Ala. — When Jeremy Johnson looks around, it doesn't take him long to find someone he knows will hold him accountable. There aren't just one or two teammates on offense Johnson believes he can count on; it's all of them...
Tray Matthews Impressing Coaches, Teammates Following Redshirt Season
Before Will Muschamp officially took over the reins of the Auburn defense, something about Tray Matthews caught his eye.....
Kiper Thinks Coates Will Be Picked Lower Than Physical Qualifications Suggest
ESPN draft analyst Mel Kiper thinks Sammie Coates has every physical tool an NFL team could want in a receiver.....
Auburn's Roc Thomas Motivated to Win Starting Job After Iron Bowl Mistake


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Actipro Software is a leading provider of .NET user interface controls for the WPF, WinRT, Silverlight, and WinForms frameworks, and is most well-known for the SyntaxEditor syntax-highlighting code editor control.
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1Down welcomes the MySpace.com community for a fun night of networking. Its time to get out from behind that computer, put on your sexy gear, grab your camera and come have some fun!
The night will be filled with the sexiest members on MySpace.com. This is not one of those "let's hype it up busted parties". This party will be a guaranteed sell out so we STRONGLY advise you to get there early.
Here a sneak peek at what's in store for the party:
Live performance by: DiamoniquE, K-9, More Coming...
DJ & Live Dancing Music provided by: DJ E Rock
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$1 Tacos
$1 Shots
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Full Bar 21 & Over Please
There is No guest list. If you're not on the flyer, you will pay $5 at the door! If you don't have $5, you don't need to be at this party. If you have a 1Down Tattoo your admission is Free.
This is all going Down at 1Down Lounge & Grill 1DownLounge.com 4020 Chino Hills Parkway Chino Hills, CA 91709 909-597-8333, Thursday, March 9, 2006 at 9pm.
Amia Miley Brazzers Contract
Epoch Club Special Event
Shade X from Smash
BBW Con 2015
UKAP Awards Site Live
Nikki Phoenix Radio Update
Ideal Image Supperclub Party
XBIZ 2016 Announced
The Interview XXX
Starfall to Exxxotica
Mercy West Available
Library Girl at Exxxotica
Karmen Karma Top Shelf
Payton Sin Claire on SDR
Angela Sommers in Houston
Prinzzess at Treasure Chest
Danica Dillon in Bath
Sin Claire with Foxxx
Adult's Achilles Heel
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New Smash VP Wyatt Case
Ink Inks OC, The Rub
National Porn Star Day
Pistol, Ross Talk Condoms
XXX Casting Call
Direct Reps Harper
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Emma Marx: Boundaries ~ Reviewer Rated
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RAW Signs Sasha Bradshaw
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Asianmodelpalooza 14
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Cumisha Amado on Vivid Radio
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Hustler EDM Maniac Party
IIM Party June 13
Discount Club Owners Expo Tickets
Teal Conrad at Sapphire NYC
Natasha Voya PSK
Alana Evans at WonderCon
Puma Swede Opens Desire
Tony Batman Conquers LA
Alexa Aimes NYC Tour
Risque Starr Sisters Parties
Carter Cruise at Exxxotica
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We examined in vivo evidence of axonal degeneration in association with neuronal pathology in Alzheimer's disease (AD) through analysis of fornix microstructural integrity and measures of hippocampal subfield atrophy. Based on known anatomical topography, we hypothesized that the local thickness of subiculum and CA1 hippocampus fields would be associated with fornix integrity, reflecting an association between AD-related injury to hippocampal neurons and degeneration of associated axon fibers. To test this hypothesis, multi-modal imaging, combining measures of local hippocampal radii with diffusion tensor imaging (DTI), was applied to 44 individuals clinically diagnosed with AD, 44 individuals clinically diagnosed with mild cognitive impairment (MCI), and 96 cognitively normal individuals. Fornix microstructural degradation, as measured by reduced DTI-based fractional anisotropy (FA), was prominent in both MCI and AD, and was associated with reduced hippocampal volumes. Further, reduced fornix FA was associated with reduced anterior CA1 and antero-medial subiculum thickness. Finally, while both lesser fornix FA and lesser hippocampal volume were associated with lesser episodic memory, only the hippocampal measures were significant predictors of episodic memory in models including both hippocampal and fornix predictors. The region-specific association between fornix integrity and hippocampal neuronal death may provide in vivo evidence for degenerative white matter injury in AD: axonal pathology that is closely linked to neuronal injury.
Neuropathological changes associated with Alzheimer's disease (AD) begin in medial temporal structures including the hippocampus (Ball, 1977; Braak and Braak, 1991). Hippocampal damage in AD features pyramidal cell neuron loss in the CA1 subfield and subiculum early in the process (Ball, 1977; Mann et al., 1985; Doebler et al., 1987; Davies et al., 1992). Consistent with this pathological finding, recent in vivo magnetic resonance imaging (MRI) studies report significant volume loss within CA1 and subiculum in AD (Csernansky et al., 2000; Wang et al., 2006; Scher et al., 2007; Chetelat et al., 2008; Frisoni et al., 2008; Xie et al., 2009; Carmichael et al., 2011) and even mild cognitive impairment (MCI; Chetelat et al., 2008), a clinical syndrome believed to represent a preclinical stage of AD (Apostolova and Thompson, 2008). Because the hippocampus is considered the major neural structure underlying episodic memory impairments that are the earliest and the most prominent clinical manifestation of AD dementia (Soininen and Scheltens, 1998; Deweer et al., 2001), the sub-regional hippocampus measures have potential as markers of brain injury that underlies the earliest cognitive symptoms leading to eventual AD dementia.
However, a number of AD studies have also observed injury to the fornix, the main axonal output pathway from the hippocampus to the mammillary body (Brodal, 1981; Aggleton and Brown, 1999; Aggleton et al., 2005). Several such studies have used fractional anisotropy (FA) derived from diffusion tensor imaging (DTI) as a measure of anisotropic water diffusion, which is believed to reflect the microstructural integrity of white matter fibers including the axon and surrounding myelin (Assaf and Pasternak, 2008; Mielke et al., 2009; Pievani et al., 2010; Agosta et al., 2011). Because the subiculum and CA1 hippocampal subfields are believed to be principal sources of hippocampal efferent fibers passing through the fornix (Rosene and Van Hoesen, 1977; Krayniak et al., 1979; Thierry et al., 2000; Aggleton et al., 2005; Cenquizca and Swanson, 2007), these findings may suggest that damage to axons connected to early sites of neuronal injury in AD may play a prominent role in the AD pathological process.
Unfortunately, the relationship between hippocampal neuronal injury and fornix injury in AD has received little study. To our knowledge, only one study to date reported a significant association between total hippocampal volume and fornix white matter integrity (Cenquizca and Swanson, 2007) although the regional specificity of that relationship to hippocampal subfields, as well as associations between both forms of injury and cognition, was not explored. Clarifying the relationships between region-specific hippocampal injury, fornix axonal injury, and cognition is important for three key reasons. First, axonal pathology with abnormal axonal transport or myelin breakdown may be a contributing factor to neuronal loss in AD (de la Monte, 1989; Bartzokis, 2004, 2011; Stokin et al., 2005), although this hypothesis has not been conclusively confirmed (Muresan and Muresan, 2009). Second, understanding the relation of axonal to cellular degeneration in AD may offer new avenues of therapeutic intervention (Bartzokis et al., 2004a; Bartzokis, 2011). Third, because successful memory function requires not only intact hippocampi but intact connectivity between hippocampi and a distributed network of memory-relevant structures (Aggleton and Brown, 1999), imaging markers of injury to hippocampal axonal outputs may provide a more complete accounting of brain injury that is relevant to clinically relevant memory loss early in the AD process.
Based on the known anatomical connectivity between the hippocampus and fornix, we hypothesized that in MCI and AD, axonopathy (as measured by reduced fornix FA) would be associated with neuronal pathology (as measured by regional hippocampus atrophy). To test this hypothesis, we began with a global approach of associating total hippocampal volume with overall fornix FA; we then examined whether hippocampal subregion atrophy was associated with reduced fornix FA in the predicted topographical manner. The behavioral relevance of these findings was further tested by examining fornix FA and hippocampal volume as predictors of domain-specific cognitive performance.
Subjects included 44 AD, 44 MCI, and 96 CN individuals. The AD group consisted of 86.4% patients with probable AD and 13.6% patients with possible AD. All MCI patients were of the amnestic subtype based on current consensus criteria for amnestic MCI (Winblad et al., 2004). The diagnosis of AD was made according to the National Institute of Neurological and Communication Disorders and Stroke/AD and Related Disorders Association criteria (McKhann et al., 1984). Although no strict psychometric cut-off scores were used to define cognitive impairment, memory impairment was defined clinically when a participant's performance fell approximately 1.5 SDs below age-matched norms and in reference to their educational and socioeconomic background. No patient had clinical history of stroke. CN was diagnosed if there was no clinically significant cognitive impairment.
Subjects were recruited from the AD Center at the University of California, Davis. All participants received a comprehensive clinical evaluation and neuropsychological testing with a standardized test battery (Morris et al., 2006). The presence or absence of stroke, diabetes, hyperlipidemia, transient ischemic attack, hypertension, and coronary artery disease was systematically assessed to create a composite score for vascular risks that was the sum of the factors present ranging 0–6 and reported as a percentage (Lee et al., 2009). In addition, all subjects received a standardized MRI scan of the brain at the baseline evaluation. The institutional review boards at all participating institutions approved this study, and subjects or their legal representatives gave written informed consent.
All brain imaging was performed at the University of California at Davis Imaging Research Center on a 1.5-T GE Signa Horizon LX EchoSpeed system. A 3D T1-weighted coronal spoiled gradient-recalled echo acquisition (T1 SPGR: TR 9.1ms, flip angle 15°, field of view 24 and slice thickness 1.5mm) and an Axial-oblique 2D DTI sequence based on single-shot spin-echo echo planar imaging (SE-EPI) with a TE of 94ms, a TR of 8000ms and a Flip angle of 90° were used to acquire the imaging data. The B-value was 1000s/mm2 with six gradient directions collected four times each, along with two B0 images. Ramp sampling was off, but phase correction for EPI was invoked. An FA map derived from DTI was obtained according to previously reported methods (Lee et al., 2009).
In order to obtain mean fornix FA values for each subject, the fornix body region of interest (ROI) was first delineated in subject native space using an automatic image warping that fitted a template mask to the native T1-weighted image. The steps to accomplish this fit are as follows:
A fornix body ROI covering the entire body part of the fornix, which contains all axonal fibers passing through the fornix, was drawn by one of the authors (CD) with substantial experience in neuroanatomy on a minimal deformation template (MDT; Kochunov et al., 2001). This mask did not include the column and crux of the fornix because these regions are too small to be reliably extracted through an ROI approach.
Before the transformation steps, subject T1-weighted images were first stripped of the skull using an in-house semi-automatic algorithm that included a user-guided cleanup phase to insure accurate brain boundaries. The fit of the template fornix body mask onto subject T1-weighted images relied on registration between the MDT template and the subject T1-weighted image including linear alignment followed by B-spline warping. This method of image registration has been previously described (Lee et al., 2009). The registration of subject T1-weighted images to the template allowed the template fornix mask to be fitted to the subject's anatomy. The subject FA image was also linearly registered to its corresponding T1-weighted image. After this automatic fitting process, we visually inspected every subject T1-weighted image and transformed fornix mask to confirm that the mask was well fitted to the fornix body in every subject.
Segmentation of gray matter, white matter, and CSF was performed on subject T1-weighted images by an in-house computer program using Bayesian maximum-likelihood EM computation (Dempster et al., 1977). Tissue probabilities used a combination of Gaussian intensity distributions and a Markov random field (MRF) for modeling tissue classification of voxel neighborhoods.
To avoid artifactual FA reductions due to CSF voxels erroneously included in the automatically fitted fornix body mask, only voxels classified as white matter in the tissue segmentation were finally included in each fornix ROI body mask. The mean FA value was calculated within each fornix ROI body based on the subject FA image aligned to the subject T1-weighted image.
Boundaries of the hippocampus of each subject were manually traced on the native T1-weighted image according to previously described methods (DeCarli et al., 2008). We used the anterior two-thirds of the hippocampus that contains most of CA1 and subiculum neurons whose axons are included in the fornix. Hippocampus volume was corrected for head size (percentage total cranial volume). Reliability of hippocampus volume using this method is quite good with intra-rater intraclass correlation coefficients of 0.98 for right hippocampus and 0.96 for left hippocampus, and intra-rater, inter-scanner intraclass correlation coefficient of 0.87 for bilateral hippocampus volume (see Carmichael et al., 2012 for details).
We used 3D hippocampal radius mapping (Thompson et al., 2004) to provide spatially localized measures of hippocampal thickness. The manually traced right and left hippocampal masks were converted to smooth high-resolution mesh surfaces. These meshes were linearly transformed using a 12-parameter affine transformation onto hippocampal masks in the template space. This transformation reduced global differences in position and scaling over the population of hippocampi, while preserving local variations in shape. In the template space the transformed meshes were converted into a set of in-slice radial lines emanating from the centroid of hippocampal area on each slice. The number of centroids and radii from each centroid were standardized to the set of radii for the right and left template hippocampi. The lengths of the radial lines provided localized thickness measurements at standardized locations on each right and left hippocampus. These thickness values were used as dependent variables in group comparisons, and dependent or independent variables in regression analyses.
For voxel-based analysis of fornix FA, each individual FA image registered to the native T1-weighted image (as described in the methods above) was warped onto the MDT through affine transformation and high-dimensional B-spline transformation previously described (Lee et al., 2009).
Group differences between CN and AD in hippocampus thickness were evaluated at every 3D surface point of the MDT hippocampus, and group differences in FA were evaluated at every voxel within the fornix body mask in MDT space. Hippocampus surface points showing significant group differences were collected into a statistical hippocampus ROI, and fornix voxels showing significant group differences were collected into a statistical fornix ROI. For each hippocampus surface point, a regression model assessed the association between thickness (dependent variable) and mean FA of the statistical fornix ROI (independent variable). For each voxel in the fornix mask (dependent variable), a regression model assessed the association between FA and mean thickness within the statistical hippocampus ROI (independent variable). All regression models included age and gender as nuisance covariates. Non-parametric permutation testing was used to correct for multiple comparisons while providing significance values for the regression models, using p<0.05 as a significance threshold (Nichols and Holmes, 2002; Thompson et al., 2003).
The results of hippocampal thickness group comparisons (p-value and percent difference maps) were displayed on a 3D hippocampal mesh surface in the space of the MDT (Figure (Figure3).3). Approximate boundaries of cytoarchitectonic hippocampal fields were schematically mapped onto the same hippocampal surface (Figure (Figure3A)3A) in consultation with a well-established source (Duvernoy, 2005). To demonstrate region-specific associations between the fornix and hippocampus, we displayed in Figure Figure44 fornix and hippocampus surfaces in MDT space showing: (a) p-values for CN vs. AD group comparisons for both fornix FA and hippocampal RD, (b) the fornix statistical ROI and, at each hippocampal surface point, the p-value for the association between fornix statistical ROI mean FA and local hippocampus thickness, and (c) the hippocampus statistical ROI, and, for every voxel intersecting the fornix surface, the p-value for the association between hippocampus statistical ROI mean thickness and FA. Additional views of the hippocampus p-values in Figure Figure4B,4B, along with an analogous R2 map, is shown in Figure Figure55.
Demographic, clinical and global MRI summary variables from the CN, MCI, and AD groups were compared by one-way analysis of variance (ANOVA) with post hoc pair wise comparisons using Tukey correction for multiple comparisons. Group differences in total hippocampal volume and statistical fornix ROI mean FA were tested by analyses of covariance (ANCOVAs) with age and gender as covariates, using Tukey post hoc correction. The association between fornix body ROI mean FA and total hippocampal volume was evaluated in a multiple linear regression model with fornix body ROI mean FA as the dependent variable and hippocampus volume, age and gender as independent variables. Associations between cognitive variables and hippocampus and fornix predictors was assessed in multiple linear regression models with the cognitive variables as dependent variables; hippocampal volume, fornix FA, or both as independent variables; and age, education, and gender as additional independent variables. Unless otherwise specified, p-values less than 0.05 were regarded as significant.
Demographic, clinical, and global MRI variables are summarized in Table Table1.1. The CN, MCI, and AD groups were broadly similar in age, education, and vascular risk. Expected stepwise differences between CN, MCI, and AD were observed in cognitive variables and global brain volume.
Mean hippocampus volume in the AD group was 10.2% lower than that of the MCI group; mean hippocampus volume in the MCI group, in turn, was 9.6% lower than that of the CN group. These group differences were statistically significant (F=17.26, df=2, p<0.001, Figure Figure1A).1A). Mean fornix FA in the AD group was 1.8% lower, and mean fornix FA in the MCI group was 1.7% lower, than in the CN group (F=12.19, df=2, p<0.001), but differences between AD and MCI groups were not significant (Figure (Figure11B).
A 1 SD increase in hippocampal volume was associated with a.41-SD increase in fornix body ROI mean FA in univariate analysis (p<0.001). Controlling for age and gender in a multiple regression model did not substantially modify this association (Figure (Figure2A).2A). Separate analyses within separate baseline clinical groups revealed that the association was significant within the MCI and AD groups considered individually, but not CN (Figures (Figures22B–D).
Hippocampal thicknesses were significantly decreased in AD vs. CN bilaterally in most of the CA1, a small region of the CA2 adjacent to CA1, and the medial part of the subiculum. In contrast, the other areas corresponding to most of the CA2–4 and dentate gyrus and the middle and lateral part of the subiculum were relatively spared in AD patients (Figures (Figures3A,B,E).3A,B,E). MCI patients also showed decreased hippocampal thickness compared to CN at smaller, but similar hippocampal regions including the bilateral anterior CA1 and antero-medial subiculum (Figures (Figures3C,F).3C,F). The AD group also had decreased thickness relative to MCI in similar regions, although the difference was statistically significant mainly in the right CA1 region adjacent to the CA2 subfield (Figures (Figures33D,G).
As shown Figures Figures4B4B and and5,5, multiple regression analyses revealed that greater mean FA in the fornix regions showing reduced integrity in AD (i.e., the statistical fornix ROI; Figure Figure4B)4B) was associated with greater thickness of bilateral antero-medial subiculum and middle-anterior CA1 subregions. The hippocampal subregions associated with fornix integrity were remarkably similar to the hippocampal subregions that were relatively atrophic in AD and MCI (Figures (Figures3B3B and and4A).4A). Similarly, lesser mean thickness of the hippocampal region that showed marked thinning in AD (i.e., the hippocampus statistical ROI; Figure Figure4C)4C) was associated with lesser FA in fornix regions that overlapped greatly with the fornix statistical ROI (Figures (Figures33A,B).
A 1 SD increase in mean fornix body FA was associated with a 0.252 SD increase in episodic memory (p=0.002) and a 0.22 SD increase in executive function (p=0.006), but mean fornix body FA was not associated with semantic memory or spatial function (Table (Table2).2). A 1 SD increase in total hippocampal volume was associated with a 0.3 SD increase in episodic memory, but not with the three other cognitive measures (Table (Table2).2). As shown in Table Table2,2, in models containing both total hippocampus volume and mean fornix body FA, the effect of fornix FA on episodic memory was no longer significant, while its effect on executive function remained. In contrast, hippocampal volume continued to show a significant effect on episodic memory in the model that also contained fornix FA.
Our ROI-based approach confirmed that both microstructural degradation of the fornix, as measured by FA, and overall hippocampal atrophy were prominent in AD and MCI. We also found through 3D thickness mapping that AD-associated hippocampal atrophy was mainly localized in the bilateral CA1 and medial subiculum subfields. In addition, greater fornix FA was associated with greater hippocampal volume as well as with greater thickness of anterior CA1 and antero-medial subiculum. Relationships between hippocampal and fornix subregions were confined to those regions that showed AD-related deficits. Finally, greater fornix integrity and hippocampal thickness and volume were associated with greater episodic memory performance, while greater fornix integrity was additionally associated with greater executive function.
Our finding of fornix microstructural disruption in AD is consistent with previous DTI studies (Mielke et al., 2009; Pievani et al., 2010; Agosta et al., 2011). In addition, however, we also found milder, but significant reductions in fornix FA in MCI subjects not previously identified by these studies (Mielke et al., 2009; Pievani et al., 2010). Enhanced statistical power with our larger sample size probably contributed to this discrepancy (Pievani et al., 2010). In addition, we measured FA within the entire body of the fornix, while one prior study (Mielke et al., 2009) measured FA from only a single slice of the fornix body, possibly leading to increased FA measurement error. Our finding in MCI, together with the results of a prior study (Ringman et al., 2007) that demonstrated fornix FA reductions in presymptomatic carriers of familial AD mutations, suggests that fornix degeneration may occur early in the AD pathological process.
In addition to overall hippocampal atrophy, we found region-specific atrophy of the CA1 and medial part of the subiculum adjacent to the presubiculum in AD, and to a lesser extent in MCI. These findings agree with prior MRI studies (Csernansky et al., 2000; Wang et al., 2006; Scher et al., 2007; Chetelat et al., 2008; Frisoni et al., 2008; Xie et al., 2009), which are in turn consistent with AD neuropathological findings (Ball, 1977; Mann et al., 1985; Doebler et al., 1987; Davies et al., 1992).
Our findings provide in vivo confirmation of topographical associations between fornix fibers and pyramidal cell bodies originating in the subiculum and CA1 subfields (Rosene and Van Hoesen, 1977; Krayniak et al., 1979; Brodal, 1981; Thierry et al., 2000; Aggleton et al., 2005; Cenquizca and Swanson, 2007). These findings suggest that microstructural degradation of the fornix is closely related to region-specific hippocampal cell loss in AD. Taken together with the observation that fornix–hippocampus relationships were significant in MCI and AD but not CN, these results strongly support the hypothesis that neuronal loss and axonal injury are not independent processes, but specifically related pathologies in the AD degenerative process. This hypothesis has been previously supported by data suggesting that axonal alterations may precede beta amyloid and even promote development of senile plaques in the cortex (Stokin et al., 2005). Other evidence suggests that, instead, axonal injury may be a downstream result of increased beta amyloid at the synapse (Muresan and Muresan, 2009). Independent of etiology, further evidence strongly suggests that axonal myelin breakdown occurs at the earliest or even preclinical stage of AD and has marked negative effects on neuronal survival (Han et al., 2002; Bartzokis et al., 2003; Bartzokis, 2004; Braak et al., 2006). Our findings support this evolving evidence suggesting shared pathogenesis between axonal and neuronal degeneration in AD. However, we caution that temporal relationships among AD pathology development, gray matter atrophy, and white matter degeneration clearly cannot be established by our cross-sectional study.
Regression analyses suggested that both hippocampal atrophy and fornix microstructural degradation were associated with episodic memory decline. These results are compatible with the established notion that, not only the hippocampus itself, but also the pathway from the hippocampus to the mammillary bodies and anterior thalamic nuclei, via the fornix (the so called extended hippocampal–diencephalic system), is critical for the efficient encoding and subsequent recall of new episodic information (Aggleton and Brown, 1999). However, when hippocampal and fornix measures were included in the same regression model, the association between fornix FA and episodic memory was no longer significant, whereas the association between hippocampal measures and episodic memory remained. This finding may favor the impact of gray matter degeneration (as measured by hippocampal volume) over white matter degeneration in the AD process, while it could also be explained by a model in which white matter injury occurs earlier, but hippocampal atrophy, once present, explains more of the variance. Fornix FA was also associated with executive function; this may be a reflection of structural or functional links between the fornix and prefrontal circuitry critical to executive function, as suggested in other mammalian studies (Thierry et al., 2000; Cenquizca and Swanson, 2007). Alternatively, reduced FA in the fornix may be a sign of more advanced disease and therefore associated with reduced executive function. Independent of exact cause for this association, these findings support the notion of AD as a syndrome of neuronal disconnection (De Lacoste and White, 1993) where widely dispersed neural systems are affected (Seeley et al., 2009). Axonal integrity is important to the fidelity of these systems and, therefore, may serve as a new avenue for therapeutic development (Bartzokis et al., 2004a,b; Bartzokis, 2011).
Our study is not without limitation. First, all subjects were clinically diagnosed. While the diagnosis of AD dementia is generally quite accurate at specialized centers such as ours, a substantial number of individuals with amnestic MCI may in fact lack indication of early AD pathology (Forsberg et al., 2008). Second, this is a cross-sectional study, so definite causal inferences between fornix and hippocampal alterations are not possible. Third, we focused only on the hippocampal output system via the fornix, but the entorhinal cortex is where neurofibrillary tangles accumulate first in the AD degenerative process (Gomez-Isla et al., 1996) and is the main input source of the hippocampus. The influence of pathology in this input system on regional hippocampal degeneration needs to be further clarified.
We found fornix microstructural alteration in MCI and AD patients that was closely associated with the hippocampus atrophy in the CA1 and medial subiculum where AD-specific neuronal loss and atrophy is marked. This region-specific relationship between fornix and hippocampal alterations indicates that cortical neuronal damage and subcortical axonal defects in AD are likely to be closely linked with each other, possibly reflecting a suggested pathogenic interaction between the two (Bartzokis, 2011), although this needs to be clarified through longitudinal studies.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
This study was supported by National Institutes of Health (K01 AG030514, P30 AG10129, R01 AG010220, R01 AG031563, and R01 AG021028) and a grant from the Dana Foundation.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Lawyers for the man known as 'Clark Rockefeller' have requested a new trial, citing judicial errors and what the defense maintains was an unqualified mental health expert.
Christian Karl Gerhartsreiter, the conman who posed as a member of the famed Rockefeller family for decades was sentenced to a maximum of five years in a Massachusetts state prison earlier this month after being found guilty of kidnapping his daughter and assaulting a social worker with a dangerous weapon.
Lawyers had maintained during the trial that the German immigrant was insane and suffering from delusions when he took off with daughter Reigh "Snooks" Boss last July.
In the court papers filed in Suffolk County, Mass., the defense argues that Suffolk Superior Court Judge Frank Gazianon erred by not providing "curative instruction" to the jury after the prosecution's closing arguments to remind jurors that Gerhartsreiter's defense was a sound one.
Prosecutors told the jury in closing arguments that the notion that Gerhartsreiter was insane at the time of his crimes was simply another attempt at manipulation, something his lawyer Jeffrey Denner said "goes beyond the pale."
"I would have asked him to say the insanity defense is a legitimate defense in the state of Massachusetts," Denner told ABCNews.com today.
The motions, which were filed last week and unsealed Thursday, also contend that the court erred when it let the jury consider testimony from the state's mental health expert, Dr. James Chu, who Denner contends gave inaccurate and inarticulate definitions of mental illness and criminal responsibility.
Suffolk County District Attorney's Office spokeswoman Erikia Gully-Santiago told ABCNews.com today the her office has received the motion and intends to respond within the 60 days allotted.
"The issued raised in this motion were raised by defense counsel during the trial," she said, "and the judge ruled in the Commonwealth's favor."
Denner said his client is struggling inside the walls of prison where he is housed with criminals convicted of much more violent crimes than he.
"He's not in a particularly pleasant place," Denner said.
In addition to the four to five years for the kidnapping conviction, Gerhartsreiter was also sentenced to a two- to three-year term for the assault, to run concurrently with the kidnapping sentence. He will serve his terms at the Massachusetts Correctional Institute in Concord, Mass.
Suffolk County District Attorney Daniel Conley said the verdict was "fair and just" and said hoped it gives Gerhartsreiter's ex-wife Sandra Boss and her daughter "some sense of justice...this was a difficult ordeal for this family," he said.
Prior to sentencing, Gerhartsreiter's ex-wife Sandra Boss and social worker Howard Yaffe, who was assaulted during the kidnapping, requested in their victim statements that Gerhartsreiter be given the fullest sentence under the law.
"While Reigh was gone, I faced a mother's worst nightmare, the possibility of losing a child without a trace," Boss said in her victim statement.
Gazianon said that he was taking into account Gerhartsreiter's first-time offender status and his seemingly genuine love for his daughter Reigh.


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The Earth Is the Lord's The Bible, Ecology and Worship
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The first verse of Psalm 24 declares that the earth is the Lord's" because it was God who "founded it on the seas and established it over the waters." In The Earth Is the Lord's Dianne Bergant explains that if the rich and elaborate religious tradition in that statement misunderstood, it can deepen our appreciation of God's creative power. She examines the relationship between humans, the earth, and worshiping the Lord by focusing on ancient and contemporary beliefs as well as key passages from the Bible.
Chapter one, A New Worldview, discusses the connection between humans and earth, an open and critical dialogue between science and theology, and the idea that humans are not the center of the universe. Chapter two, Creation and Re-creation, focuses on the Sabbath, the sanctuary, a sacred time and place, and the image of God. Chapter three, Nature: Friend or Foe?, examines nature. Chapter four, Creation and Morality, takes a close look at morality. The final chapter, On That Day, discusses the day of the Lord, a new heaven and a new earth, and the Messianic Age.
Sister Dianne Bergant CSA, is Professor of Old Testament studies at Catholic Theological Union in Chicago. The general editor of TheCollegeville Bible Commentary (Old Testament), she was editor of The Bible Today from 1986-1990."
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He's on My Mind
Not Yet Rated| 1 hr. 59 min.
Plot Summary
A jilted woman gains the power to read men's thoughts and tries to figure out why they cheat.
Cast: Ayo Sorrells , Dylan Mooney , Shamari Berkley , Deja Lewis Smith , Shonelle Blake , Liza Tichenor , Alisha Boe , Jeremy Batiste
Director: Kazeem Molake
Genres: Romantic comedy


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I need to speak to someone in charge at greendot about my card and its transaction, and my money. I cant get a hold of nobody and i need to get a hold of someone now. Every freaking number i call it says i got the wrong number and call on the back of my card. .
Looked up website info to get a refund on a Moneypak card. This site looked completely legit
I called, the man who answered took my address and the Moneypak number and said i would receive a refund check in 7-10 business days. That time passed and i called. He hung up on me and when i tried to call again it was continuously busy. I then tried calling with my cell and the same thing. There has to be a way to find this man, Why can't i find someone to speak to in a fraud department? Why is it impossible to talk to a human?
hung up within two seconds. It totally sucks money pack is made for scam only.
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I placed $160. 00 to reload my card and it was not received. I need an investigation as to where my funds went.
Please help i bought Moneypak total to $1, 500 and paid after paying i called eBay to verify, but the told me it was not them hence its scum. Help me please to get my money back.
Need you Help, i bought Moneypak and send, but it seems to be a scum.
I bought Moneypak today from cvs and walgreen both worthy $1, 500. The deal was to pay for the vehicle i got on ebay after paying the and called ebay they told me that was not them. They said it was a scam. Now i wanted your help.
I need to talk to someone about a recent issue. I put $300 on a Moneypak card and was asked to scratch the numbers off the back of the card in order to get my refund. I never received my refund. I tried calling the 1-818-570-5090 and I talked to a man and he asked me if I had a confirmation number and I told him number. He asked who I had spoken to about the refund and I told him a man. He put me on hold and then hung up the phone. I tried calling the number back and the phone would give a busy signal. Why would people tried to scam people out of their money. This is very sad and unprofessional.
This happened to me too. Why is it so impossible to get help to catch these crooks?.


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StartUpHire is the place to find Alliances Marketing Director jobs. Review the list of Alliances Marketing Director career opportunities to the left. These Alliances Marketing Director jobs represent some of the most rewarding careers available.
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San Mateo, CA About the Job Nexant's innovative software manages energy efficiency, demand side management, demand response, and distributed generation. It enables smart grid rates and customer-facing products and services and improves the physical and financial operational5/10/2015 San Mateo, CA Save This Job
Director Business Development & Technical Alliances To continue our high growth and to meet the demands of emerging market opportunities, we are seeking an experienced, motivated, and creative industry leader to manage our strategic business development & technical alliances4/19/2015 Palo Alto, CA Save This Job
PowerReviews delivers software that more than 1,000 brands and retailers utilize to collect, display, and syndicate reviews on more than 5,000 websites. An essential resource for consumers as they search and shop online and in-store, reviews drive traffic, increase sales, and6/16/2015 Chicago, IL Save This Job
Reporting to the Vice President of Utility Sales, the Strategic Alliances Director will accelerate EcoFactor?s growth by developing revenue-generating partnerships with system integrators, consulting firms, and energy efficiency and demand response implementors. The ideal5/25/2015 Redwood City, CA Save This Job
A serious mission, a fun and energetic place to get it done, Xactly. We are a growing, fast-paced, Cloud (SaaS) based company in search of people who want to make a real impact on their team, their company and the business world. As one of Salesforce.com?s (SFDC) most strategic6/30/2015 San Jose, CA Save This Job
Job Number:003883 Job Title:Director, Partner Sales Number of Openings:1 Job Type (Employment Type):Direct Hire Country:United States State/Province:Illinois City:Chicago Job Schedule:Full Time Level of Education:Four-Year Degree Years of Experience:10 Position Description Job5/4/2015 Chicago, IL Save This Job
About the company:NetBase delivers premium enterprise-class social listening and analytics for brands and agencies. Our platform processes billions of social media posts to extract actionable business insights using our high-precision natural language processing (NLP) engine and6/19/2015 Mountain View, CA Save This Job
Director of Product ManagementClick here to see all openings!Company Overview:Velocify is one of the fastest growing software-as-a-service companies in the country, providing the market-leading solution for intelligent sales automation and cloud-based telephony. Velocifyâs5/24/2015 El Segundo, CA Save This Job
The Global Channel Marketing Manager will be responsible for developing and executing strategic marketing activities to scale the business. You will be involved in building the go-to-market plan in collaboration with key stakeholders, leveraging global marketing activities and6/3/2015 San Jose, CA Save This Job
Location: Redwood City, CA Opportunity: Today?s communications landscape is dynamic and increasingly complex. Actiance allows companies to use email, enterprise social software, unified communication, instant messaging, and social media in a way that allows them to improve6/2/2015 Redwood City, CA Save This Job
Marketing San Mateo, CA, United States Director of Brand & Corporate Marketing About Conviva With a view into billions of streams per month from billions of unique devices, only Conviva can deliver online video providers the power to navigate the pitfalls of delivering6/23/2015 San Mateo, CA Save This Job
Job ID 2015-2414 Location US-NC-Morrisville Category Marketing Type Regular Full-Time More information about this job: Overview: SciQuest is the largest publicly-held provider of Software-as-a-Service (SaaS) procure-to-pay technology. We?re on a Quest to develop and implement5/29/2015 Morrisville, NC Save This Job
Sales - (Multiple states) - Full Time Company Overview Cloudmark is the most trusted leader in security ? protecting traffic, data and infrastructure. We safeguard service providers, enterprises and consumers worldwide with immediate, predictive protection from ever-evolving5/9/2015 San Francisco, CA Save This Job
As an Enterprise Channel Sales Director, you will be a hands-on ?player/coach,? building channel relationships and leading a focused channel team. You will work very closely with the direct sales team, as all deals will flow through the channel. You?ll work closely with the6/4/2015 Broomfield, CO Save This Job
Job ID 2015-1581 Job Location US-GA-Atlanta Type Regular Full-Time Posted Date 1/26/2015 Targeted Job Start Date .. More information about this job: POSITION SUMMARY & RESPONSIBILITIES: Virtustream (www.virtustream.com) is a leading enterprise cloud software and services6/3/2015 Atlanta, GA Save This Job


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Paa Joe's sculpted coffins blur the line between art and craft. Each work is carefully constructed to reflect the ambition or the trade of the person for whom it was made. They are not dead things but are instead a manifestation of and indeed an affirmation of life. The works are wholly African and are a contemporary embodiment of traditional tribal burial rituals and art practice. They link back to pre-colonial West African sculpture but also recall the pomp and extravagance of ancient Egyptian royal tombs.
Matthew Harlan
Gorgeous typography, beautiful color schemes, and hard edged geometric patterns can be found in the work of Matthew Harlan.
Felisa Funes
Felisa Funes blurs the lines between sculpture, painting, and collage in her works. Each piece looks like the love child of Wangechi Mutu sculptures and early Julian Schnabel paintings.
Design Watch: Bernhard Burkard
Bernhard Bukard's Curt Deck Chair is probably the coolest outdoor furniture we've seen in a while. On his site Bernard assures us that, "even though it looks dangerous it provides comfort seating and relaxing in every occasion. To achieve best stability, it needs to be leaned against walls or rails in a flat angle. The anti-slip coated stand provides safe grip on every surface."
DANIELE BUETTI's The Great Cold Slipped Right Under My Nose
It's surprising that I'm just discovering this epic 2004 installation by Daniele Buetti. Titled Le Grand Rhume (The Great Cold) this piece features a massive larger than life nose complete with skin blemishes,discoloration, and bad pores crashing through the roof of an old hut and dripping a gooey pile of stalagmites from the nostril. I'm not usually a fan of nasal drips but this just be one of my all time favorite sculptures! More shots of the install after the jump.
Little People In A Big World
I usually wouldn't describe street art as "sweet" but there is something delicate, nostalgic, and endearing about street artist Slinkachu's "Little People" project. Started in 2006, Slinkachu paints miniature model train set characters, which he stages and sets in city streets. The works are documented via photographs but Slinkachu views them more as site specific installations. The scenes reflect the loneliness and melancholy that his cast of characters feel from living in the city, where these tiny people are lost and overwhelmed in a world not built for them.
Jeff Davis' Rituals
Jeff Davis' drawings and sculptures of pastel colored, nude bearded men sacrificing humans to the geometric gods.
Greg Hopkins Update
We posted Greg Hopkins work back in 2009 when he was painting heavily detailed floral patterned paintings. Recently I visited Greg's site and was pleasantly surprised by the new exciting direction for his work. The flowers have been replaced by tightly painted geometric patterns weaving in, out, and into faux paint drips.


text: A Rape Joke That Will Actually Make You Laugh Anna NorthProfileFollowUnfollow Anna NorthFiled to: Comedy Ever mainard rape jokes Rape sexual Assault 2/02/12 7:15pmEditDelete Invite manuallyPromoteXDismissXUndismissBlock for jezebelHideShare to KinjaGo to permalink And cringe. Above, Ever Mainard proves that rape jokes can be funny — in this case, funny because they're true. 209Reply 209Discuss


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1999 Mercury Mountaineer Q&A
1999 Mercury Mountaineer Question: 4x4 making loud bangs, but two wheel drive is ok. should I fix or sell?
my 4x4 isn't working well, when I steer sharp it makes loud banging noises. the brake pedal shakes and steering wheel does too when braking making me think the rotors are bad. the vehicle is squirrely on the road and going down the road feels like I'm running on flat tires. Is there hope or is it time to move on? what kind of repairs am I looking at? I put a new transmission in it in 2010 so I am not sure why the 4x4 wont work. - azerkle
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Great review of Out On A Limb. Thanks to Scott Hopkins for the article!
Music Fest News
Ropeadope + Jazz Fest
As we roll into Jazz Fest Season 2015, we've got quite a bit of excitement buzzing around the Naughty camp. A smorgasbord of Jazz Fest shows, both at the Fest and in the city at night, keeps us busy throughout the coming weeks. Noah (our bass player) is getting ready to graduate from University of New Orleans, thus finally eliminating the last traces of the "college factor" which has found ways to sabotage our touring efforts since the beginning (it should be noted that UNO is, when compared to other universities in town, very understanding of musicians' touring schedules).
Some big news: We finished our album Out On A Limb, and can't wait to release it to the world in May. Some perhaps bigger news: Out On A Limb is being released through our new partners, Ropeadope Records! We're humbled and honored to be rubbing label-buddy elbows with the likes of Snarky Puppy, Sidewalk Chalk and many other great bands who are striving to push the boundaries. We can't wait to hit the ground running with our new friends and make music together.
If you're looking to get your hands on OOAL before May, come see us play and we'll have CD's for sale at the show (or at the merchandise tent at Jazz Fest!).
This summer we intend to tour around the country. We'll let you know as soon as we have a clear sense of where we're headed. In the mean time, check out this new video from our Live at the Blue Nile series featuring one of the songs from OOAL, The Elephant Hunt.
Brain Storm
Our new single is here! Check it out.
Music Season
It's Mardi Gras Season! Which for New Orleans means music, music, music.
We've got some goodies we're about to send out into the cosmos. First, shows!
We're kicking Mardi Gras off in stride with a show on Krewe du Vieux at Blue Nile. and wrapping it up with shows at The Howlin' Wolf and La Maison on Frenchman St. As the good people of New Orleans know, Mardi Gras season brings the best out of a lot of aspects of the city, and the array of music events is no exception. As more folks visit our fair city, the music scene kicks it up a notch. For instance, the sheer talent brought in is spectacular. Acts from all over the country come to entertain the masses.
Perhaps a more secret side of the Mardi Gras festivities is the impromptu jam sessions that occur at the wee hours of the morning when all the musicians are done playing with their respective bands. It's a really exciting community to realize you're a part of, sometimes by accident. It's interestingly selective in a way, because the only people that tend to be around for these special moments are people who are willing to stay up till 3 a.m. to maybe see some more music before the city sleeps.
We're also on the cusp of releasing…(drumroll)…a new single! We'll be dropping a brand newly recorded song that will appear on our new album. Look out for it in the coming weeks!
Happy Mardi Gras!
New Year, Same Love
By John
Thanks to you, our 2014 was truly amazing.
We're in the middle of our winter schlep through the Northeast, and I have to say, it's going really well.
We're finally getting around to hitting quite a few cities up here a second time (and some for a third time!), and we are thrilled to see so many familiar faces. Other than me breaking my arm sledding in Vermont (went off a ramp really fast…almost worth it), this tour has been full of nothing but great crowds and quality hang time with lovely humans.
We've hit quite a few milestones during this trip around the sun, and we absolutely owe it all to you, our amazing families, friends, and fans. Since last January, we've cultivated wonderful friendships, experienced many triumphs and losses, played shows alongside incredible musicians (The Revivalists, The Main Squeeze, The Nth Power, Rebirth Brass Band, George Porter Jr., and more), travelled across the majority of our great nation, and recorded an album, all of which have helped us grow to become better people and a better band as a whole. Thank you, dear friends, for all the love and for being a part of our musical journey!
We have a lot to look forward to in 2015, including a very exciting Mardi Gras season in New Orleans (BOLO for those dates!), releasing a new album, and more touring. We'll be touring through January 17th, and will post more shows as they approach.
From all of Naughty Professor,
Happy New Year!
The Nth Power and The Main Squeeze Blow My Mind + Winter Tour
Hello again everyone! As we take a well-earned break for Thanksgiving, I can finally sit back and digest some things Naughty Professor has experienced recently. We've played a ton of shows, recorded our new album at Studio in the Country, and are about to embark on a quest through the blizzard-gauntlet that is the North East for a winter tour. Spending more time away from New Orleans than ever, our van is beginning to feel more and more like a second home.
Recently Naughty ventured East to play with some incredible up and coming bands that left me spellbound and genuinely inspired. Our first show was at a great new venue in Atlanta Aisle 5 with The Nth Power, a relatively new soul group born in New Orleans with a stacked lineup (includes New Orleans mainstay drummer Nikki Glaspie, former drummer for Dumpstafunk, and soul-expert Nigel Hall on keys) playing music that comes straight from the heart. In my opinion, The Nth Power plays nothing but honest to goodness musical truth.
Then we drove up to Charleston, SC for a show with The Main Squeeze, a powerhouse of a funk/rock group that specializes in flawless execution and soul-ridden song writing. They are a hook machine, a hit factory (If you couldn't already tell, I like them a lot). No doubt they will continue to explode in the music scene. It was really cool to play with them and I look forward to doing it again!
Coming up next: our 2014-2015 Winter Tour. We're foraging through the snow to reach GA, NC, D.C., MA, PA, VT, and NY. Having lived in the South my whole life, this experience is a first for me. I've never been that far North this deep into winter before, but I think I'm capable of living through it, even if I have to slay a Taun Taun to keep warm.
Check out our shows page for specific dates!
We hope to see all of you soon.
- by John
Operation Voodoo: Success
This weekend we played five shows in three days, during a great tour through Texas with The Revivalists and The London Souls, concluding with a Voodoo set and a raging sold-out Tipitina's afterparty. It was an ambitious and enthralling experience that has left us exhausted and victorious. Thanks to everyone who came out to one of our shows!
After Naughty's Voodoo set, Meg Ryan from LSU's The Daily Reveille interviewed Sam and John about Naughty's roots and style, which can be found by clicking the horns below.
Live at Blue Nile
Check out our new video from our show at Blue Nile!


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Family Reunion 2015 by - 3 days ago
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2015 AP Stats Prediction Run by Loving our Custom Ink Shirts! - 11 days ago
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Thomas Reunion in Branson, MO by Thomas Reunion - 23 days ago
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Future Nurses Rocking the Town by Jen - about 2 months ago
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DPU Volleyball takes on NCVF Nationals! by DPUWVBC - 3 months ago
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Fighting For Fred Climb Team by Fighting For Fred MET Climb - 3 months ago
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Voltage of Imagination, Robotics Team 7591! by Robotics Team 7591 Voltage of Imagination - 3 months ago
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Team Scott--Tribute Day!! by Robyn - 8 months ago
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Outside the Lines Art Gallery
A retail gallery specializing in original art and fine craft from more than 100 U.S. artists.
Galena Center for the Arts
Celebrating regional art in its many forms: special exhibits, performances, regional artwork gallery, photography from the historic Alfie Mueller collection.
Fever River Adventure Triathlon
Test your endurance with a 6-mile paddle, 17-mile Bike and 3.1-mile run through the Galena River and trails. Individual or 3 person relay teams. Proceeds benefit the Special Olympics of Illinois.
Market House Suare Arts Festival
Browse the many exhibits by local and regional artists showcasing their paintings, woodwork, jewelry, pottery, baskets, and more for our 8th annual outdoor art festival. Local musicians will perform throughout the day. Plenty of food and beverages available for purchase.
Murder Mystery at the Vineyard
Who did it? Enjoy a wonderful catered dinner and become a part of the mystery that takes you back in time to 1933 at "The Cellars." Advanced reservations required, limited seating.
10th Annual Pilot's Reunion
Aviation enthusiasts opportunity to visit with old time pilots and view pilot and plane memorabilia. Over 300 private pilots trained in Stockton at a country airstrip from 1930-1960. Jake Rausch will present on the Eighth Air Force out of Tibethan AFB in Norwich, England.
Fall Harvest & Art Festival in the Vineyard
A fun-filled day celebrating the fruits of our labor: Food booths, art show featuring the talents of the Galena Cultural Arts Alliance, vineyard tours and hayrides. Live entertainment. Fun for the entire family including pumpkin painting and grape stomps.
NW IL Art Fest
Juried art fest with artists arriving from throughout the tri-state area to showcase and sell their work. Food vendors will be on hand to add to the festivities.
155th Annual Jo Daviess County Fair
Celebrate with the oldest fair in Illinois. Livestock shows, exhibits, tractor pull, draft horse pull, motocross and ATV races, live entertainment, fair foods, carnival rides and more.
The Grateful Gourmet Co.
A unique kitchenware and specialty food store for the gourmet chef in all of us.
Blaum Bros. Distilling Co.
The Blaum Bros. Distilling Co. was founded by two brothers looking to create a truly unique product and experience in historic Galena. By sourcing grains from local farmers and controlling the entire process in their purpose-built facility, they're able to meticulously produce the highest quality spirits from their custom, hand made copper still. In a world overrun by mass production and corporate shenanigans, join them in creating something real - something genuine.
Bootlegger Saloon
Featuring daily lunch specials. Home of The Bootburger. Big screen TVs & internet jukebox.
Wooden Wardrobe
Fun! Fun! Fun! Women's clothing, Polish Pottery, custom fine woodworking, Trollbeads, vintage personalized signs, Venesha Angora, West Highland Terrier puppies.
From Head to Toe Sportswear
Featuring Columbia, Woolrich, Life is Good, Speedo, Hush Puppies, Smartwool. Apparel, outerwear, shoes and accessories for men, women and children.
Down the Street Boutique
Located on picturesque Main Street Galena, this unique boutique features Miche bags, Lindsay Phillips Switch Flops, Not Your Daughter's Jeans and beaded watch bands and faces.
Old School Saloon
Historical and original, the Old School Saloon offers a welcoming atmosphere with drinks and tasty food served with a smile.
CITY:Scales Mound
Seasons Remembered
A season for everyone. From St. Patrick's Day to Christmas, plus many more exciting, unique gifts and collectibles.
Pat's Country House Grocery
One of the county's oldest grocery stores, offering hand-cut steaks and pork, with homemade brats, sausage, pizza, cheese/deli trays, fruit baskets.
CITY:Scales Mound
Towne Rebel
For over a decade, Towne Rebel has been offering an eclectic mix of women's clothing, home decor and small furnishings. French country home décor. Hand-knit, cotton sweaters. Timeworks, Inc. clocks. Quilted linens for tables/bedding. Decorative/usable canister sets for kitchen.
The Shop on the Hill
Antiques fill the entire first floor of Victorian home. This is an old general line antique shop that has been in business for more than 25 years. Glassware, furniture, tools, books, primitives, toys, collectibles and more!
The Blueberry Cottage
More than 30 years in business selling enamelware, metal plate displays, dishes, candles, linens, seasonal ornamentation and pet goodies.
Mid-Town Marina
Full-service marina, restaurant and lounge on the Mississippi River in East Dubuque.
CITY:East Dubuque
Slumber, Inc.
Boutique specializing in the best in comfortable sleepwear, lingerie, loungewear for women of all ages, sizes XS to 3X.
Grant Hills Motel
Galena's Value Motel. Offering simple comforts of home: one-three beds/room, mini fridges, convenient parking. Laundry/kitchen facilities. Fitness equipment. Gas grills, picnic pavilion, volleyball, bean bags. Dog-friendly. Spacious backyard, scenic views.


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shah rukh khan salman khan
7 shah rukh khan salman khan Articles
Shah Rukh beats Salman and Aamir, wins the 'sexiest Khan at 50′ title!5 months ago 43
We recently conducted a poll asking our readers to vote and tell us which Khan looks sexiest at 50. While Mr Perfectionist was way behind in the… Read Article ▶
Shah Rukh Khan forgets congratulating Salman Khan on Kuch Kuch Hota Hai 16th Anniversary!9 months ago 3
The Happy New Year actor wishes everyone from the cast of K2H2 except for Salman. We wonder why... Karan Johar's Kuch Kuch Hota Hai completed 16… Read Article ▶
Bigg Boss 8 exclusive: 12 contestants, 82 cameras, 90 days, promises Salman Khan!10 months ago 5
The Kick star is creating a huge buzz with his TV reality show this season... Salman Khan's much awaited reality show Bigg Boss 8 is finally here… Read Article ▶
Salman Khan: We will promote Shah Rukh Khan's Happy New Year!10 months ago 15
The Dabangg Khan became candid and spoke about his equation with SRK at the Bigg Boss 8 launch Salman Khan and Shah Rukh Khan seem to have finally… Read Article ▶
Bigg Boss 8 exclusive: Salman Khan and VJ Andy set the stage on fire at Bigg Boss inauguration-View pics!10 months ago 0
Th Kick star makes a grand entry at the Bigg Boss 8 inauguration party Bigg Boss 8 has been launched today. Salman Khan, the host of the show… Read Article ▶
Salman Khan: Shah Rukh Khan should host Bigg Boss 8!12 months ago 3
The Dabangg Khan became candid and spoke about his equation with SRK Salman Khan and Shah Rukh Khan seem to have finally hugged and done away with… Read Article ▶
Yogen Shah
Shahrukh Khan wants to be like Salman when he grows up!4 years ago 2
King Khan refuses to consider himself as a grown up man and says that he aspires to be like the 'bodyguard' some day! The SRK-Salman brawl has been… Read Article ▶
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