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Publications (152)2509.41 Total impact
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Article: Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.[Show abstract] [Hide abstract]
ABSTRACT: To assess factors influencing the success of whole-genome sequencing for mainstream clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families across a broad spectrum of disorders in whom previous screening had identified no pathogenic variants. We quantified the number of candidate variants identified using different strategies for variant calling, filtering, annotation and prioritization. We found that jointly calling variants across samples, filtering against both local and external databases, deploying multiple annotation tools and using familial transmission above biological plausibility contributed to accuracy. Overall, we identified disease-causing variants in 21% of cases, with the proportion increasing to 34% (23/68) for mendelian disorders and 57% (8/14) in family trios. We also discovered 32 potentially clinically actionable variants in 18 genes unrelated to the referral disorder, although only 4 were ultimately considered reportable. Our results demonstrate the value of genome sequencing for routine clinical diagnosis but also highlight many outstanding challenges.Nature Genetics 05/2015; DOI:10.1038/ng.3304
Article: TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer[Show abstract] [Hide abstract]
ABSTRACT: To determine early somatic changes in high-grade serous ovarian cancer (HGSOC), we performed whole genome sequencing on a rare collection of 16 low stage HGSOCs. The majority showed extensive structural alterations (one had an ultramutated profile), exhibited high levels of p53 immunoreactivity, and harboured TP53 mutation, deletion or inactivation. BRCA1 and BRCA2 mutations were observed in two tumors, with nine showing evidence of a homologous recombination (HR) defect. Combined analysis with The Cancer Genome Atlas indicated that low and late stage HGSOCs have similar mutation and copy number profiles. We also found evidence that deleterious TP53 mutations are the earliest events, followed by deletions or loss of heterozygosity (LOH) of chromosomes carrying TP53, BRCA1 or BRCA2. Inactivation of HR appears to be an early event, as 62.5% of tumours showed a LOH pattern suggestive of HR defects. Three tumours with the highest ploidy had little genome-wide LOH, yet one of these had a homozygous somatic frame-shift BRCA2 mutation, suggesting that some carcinomas begin as tetraploid then descend into diploidy accompanied by genome-wide LOH. Lastly, we found evidence that structural variants (SV) cluster in HGSOC, but are absent in one ultramutated tumor, providing insights into the pathogenesis of low stage HGSOC. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.Nucleic Acids Research 04/2015; DOI:10.1093/nar/gkv111
Article: Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome[Show abstract] [Hide abstract]
ABSTRACT: Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options. GBM has been shown to predominantly disrupt three core pathways through somatic aberrations, rendering it ideal for precision medicine approaches. We describe a 35 year-old female patient with recurrent GBM following surgical removal of the primary tumor, adjuvant treatment with temozolomide, and a 3-year disease-free period. Rapid whole genome sequencing (WGS) of three separate tumour regions at recurrence was performed and interpreted relative to WGS of two regions of the primary tumour. We found extensive mutational and copy number heterogeneity within the primary tumour. We identified a TP53 mutation and two focal amplifications involving PDGFRA, KIT and CDK4, on chromosomes 4 and 12. A clonal IDH1 R132H mutation in the primary, a known GBM driver event, was detectable at only very low frequency in the recurrent tumour. After subclonal diversification, evidence was found for a whole genome-doubling event and a translocation between the amplified regions of PDGFRA, KIT and CDK4, encoded within a double minute chromosome also incorporating miR26a-2. The WGS analysis uncovered progressive evolution of the double minute chromosome converging on the KIT/PDGFRA/PI3K/mTOR axis, superseding the IDH1 mutation in dominance in a mutually exclusive manner at recurrence, consequently the patient was treated with imatinib. Despite rapid sequencing and cancer-genome guided therapy against amplified oncogenes, the disease progressed, and the patient died shortly after. This case sheds light on the dynamic evolution of a GBM tumor, defining the origins of the lethal subclone, the macroevolutionary genomic events dominating the disease at recurrence and the loss of a clonal driver. Even in the era of rapid WGS analysis, cases such as this illustrate the significant hurdles for precision medicine success. © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology.Annals of Oncology 03/2015; 26(5). DOI:10.1093/annonc/mdv127
Article: Reply to Pembrey et al: 'ZNF277 microdeletions, specific language impairment and the meiotic mismatch methylation (3M) hypothesis'European journal of human genetics: EJHG 12/2014; DOI:10.1038/ejhg.2014.275
Article: Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burdenNature Communications 04/2014; 5. DOI:10.1038/ncomms4756
- European Journal of HumanGenetics 02/2014; 22(10):1165-1171. DOI:10.1038/ejhg.2014.4
Article: An Enhancer Polymorphism at the Cardiomyocyte Intercalated Disc Protein NOS1AP Locus Is a Major Regulator of the QT Interval[Show abstract] [Hide abstract]
ABSTRACT: QT interval variation is assumed to arise from variation in repolarization as evidenced from rare Na- and K-channel mutations in Mendelian QT prolongation syndromes. However, in the general population, common noncoding variants at a chromosome 1q locus are the most common genetic regulators of QT interval variation. In this study, we use multiple human genetic, molecular genetic, and cellular assays to identify a functional variant underlying trait association: a noncoding polymorphism (rs7539120) that maps within an enhancer of NOS1AP and affects cardiac function by increasing NOS1AP transcript expression. We further localized NOS1AP to cardiomyocyte intercalated discs (IDs) and demonstrate that overexpression of NOS1AP in cardiomyocytes leads to altered cellular electrophysiology. We advance the hypothesis that NOS1AP affects cardiac electrical conductance and coupling and thereby regulates the QT interval through propagation defects. As further evidence of an important role for propagation variation affecting QT interval in humans, we show that common polymorphisms mapping near a specific set of 170 genes encoding ID proteins are significantly enriched for association with the QT interval, as compared to genome-wide markers. These results suggest that focused studies of proteins within the cardiomyocyte ID are likely to provide insights into QT prolongation and its associated disorders.
Article: SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage[Show abstract] [Hide abstract]
ABSTRACT: SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTP TPH) and a nuclease that restricts HIV-1 in non-cycling cells. Germline mutations in SAMHD1 have been described in patients with Aicardi-Goutières syndrome (AGS), a congenital autoimmune disease. In a previous longitudinal WGS study of chronic lymphocytic leukemia (CLL) we revealed a SAMHD1 mutation as a potential founding event. Here, we describe an AGS patient carrying a pathogenic germline SAMHD1 mutation who developed CLL at 24 years of age. Using clinical trial samples, we show that acquired SAMHD1 mutations are associated with high variant allele frequency, reduced SAMHD1 expression and occur in 11% of relapsed/refractory CLL patients. We provide evidence that SAMHD1 regulates cell proliferation and survival and engages in specific protein interactions in response to DNA damage. We propose that SAMHD1 may have a function in DNA repair and that the presence of SAMHD1 mutations in CLL promotes leukemia development.Blood 12/2013; 123(7). DOI:10.1182/blood-2013-04-490847
Article: Abstract B017: A targeted sequencing approach to characterize the mutational profiles of 178 genes in 2600 primary breast tumorsMolecular Cancer Research 10/2013; 11(10 Supplement):B017-B017. DOI:10.1158/1557-3125.ADVBC-B017
Article: Genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.[Show abstract] [Hide abstract]
ABSTRACT: We present the analysis of a prospective multicentre study to investigate genetic effects on prognosis of newly treated epilepsy. Patients with a new clinical diagnosis of epilepsy requiring medication were recruited and followed up prospectively. Clinical outcome was defined as freedom from seizures for a minimum of 12 months in accordance with the consensus statement from the International League Against Epilepsy (ILAE). Genetic effects on remission of seizures after starting treatment were analysed with and without adjustment for significant clinical prognostic factors, and the results from each cohort were combined using a fixed effects meta-analysis. After quality control, we analysed 889 newly treated epilepsy patients using 472,450 genotyped and 6.9 x 10(6) imputed single nucleotide polymorphisms. Suggestive evidence for association (defined as Pmeta<5.0 x 10(-7)) with remission of seizures after starting treatment was observed at three loci: 6p12.2 (rs492146, Pmeta=2.1 x 10(-7), OR[G]=0.57), 9p23 (rs72700966, Pmeta=3.1 x 10(-7), OR[C]=2.70) and 15q13.2 (rs143536437, Pmeta=3.2 x 10(-7), OR[C]=1.92). Genes of biological interest at these loci include PTPRD and ARHGAP11B (encoding functions implicated in neuronal development) and GSTA4 (a phase II biotransformation enzyme). Pathway analysis using two independent methods implicated a number of pathways in prognosis of epilepsy including KEGG categories 'calcium signaling pathway' and 'phosphatidylinositol signaling pathway'. Through a series of power curves, we conclude it is unlikely any single common variant explains >4.4% of the variation in outcome of newly treated epilepsy.Human Molecular Genetics 08/2013; DOI:10.1093/hmg/ddt403
Article: Homozygous mutations in a predicted endonuclease cause Congenital Dyserythropoietic Anemia Type I.[Show abstract] [Hide abstract]
ABSTRACT: The congenital dyserythropoietic anemias are a heterogeneous group of rare disorders primarily affecting erythropoiesis with characteristic morphological abnormalities and a block in erythroid maturation. Mutations in the CDAN1 gene, which encodes Codanin-1, underlie the majority of congenital dyserythropoietic anemia type I cases. However, no likely pathogenic CDAN1 mutation has been detected in 20% of cases, suggesting the presence of at least one other locus. We used whole genome sequencing and segregation analysis to identify a homozygous T to A transversion (c.533T>A), predicted to lead to a p.L178Q missense substitution in C15ORF41, a gene of unknown function, in a consanguineous pedigree of Middle-Eastern origin. Sequencing C15ORF41 in other CDAN1 mutation-negative congenital dyserythropoietic anemia type I pedigrees identified a homozygous transition (c.281A>G), predicted to lead to a p.Y94C substitution, in two further pedigrees of South-East Asian origin. The haplotype surrounding the c.281A>G change suggests a founder effect for this mutation in Pakistan. Detailed sequence similarity searches indicate that C15ORF41 encodes a novel restriction endonuclease that is a member of the Holliday junction resolvase family of proteins.Haematologica 05/2013; DOI:10.3324/haematol.2013.089490
Article: Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.[Show abstract] [Hide abstract]
ABSTRACT: Cancers acquire resistance to systemic treatment as a result of clonal evolution and selection. Repeat biopsies to study genomic evolution as a result of therapy are difficult, invasive and may be confounded by intra-tumour heterogeneity. Recent studies have shown that genomic alterations in solid cancers can be characterized by massively parallel sequencing of circulating cell-free tumour DNA released from cancer cells into plasma, representing a non-invasive liquid biopsy. Here we report sequencing of cancer exomes in serial plasma samples to track genomic evolution of metastatic cancers in response to therapy. Six patients with advanced breast, ovarian and lung cancers were followed over 1-2 years. For each case, exome sequencing was performed on 2-5 plasma samples (19 in total) spanning multiple courses of treatment, at selected time points when the allele fraction of tumour mutations in plasma was high, allowing improved sensitivity. For two cases, synchronous biopsies were also analysed, confirming genome-wide representation of the tumour genome in plasma. Quantification of allele fractions in plasma identified increased representation of mutant alleles in association with emergence of therapy resistance. These included an activating mutation in PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) following treatment with paclitaxel; a truncating mutation in RB1 (retinoblastoma 1) following treatment with cisplatin; a truncating mutation in MED1 (mediator complex subunit 1) following treatment with tamoxifen and trastuzumab, and following subsequent treatment with lapatinib, a splicing mutation in GAS6 (growth arrest-specific 6) in the same patient; and a resistance-conferring mutation in EGFR (epidermal growth factor receptor; T790M) following treatment with gefitinib. These results establish proof of principle that exome-wide analysis of circulating tumour DNA could complement current invasive biopsy approaches to identify mutations associated with acquired drug resistance in advanced cancers. Serial analysis of cancer genomes in plasma constitutes a new paradigm for the study of clonal evolution in human cancers.Nature 04/2013; DOI:10.1038/nature12065
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ABSTRACT: Background The management of metastatic breast cancer requires monitoring of the tumor burden to determine the response to treatment, and improved biomarkers are needed. Biomarkers such as cancer antigen 15-3 (CA 15-3) and circulating tumor cells have been widely studied. However, circulating cell-free DNA carrying tumor-specific alterations (circulating tumor DNA) has not been extensively investigated or compared with other circulating biomarkers in breast cancer. Methods We compared the radiographic imaging of tumors with the assay of circulating tumor DNA, CA 15-3, and circulating tumor cells in 30 women with metastatic breast cancer who were receiving systemic therapy. We used targeted or whole-genome sequencing to identify somatic genomic alterations and designed personalized assays to quantify circulating tumor DNA in serially collected plasma specimens. CA 15-3 levels and numbers of circulating tumor cells were measured at identical time points. Results Circulating tumor DNA was successfully detected in 29 of the 30 women (97%) in whom somatic genomic alterations were identified; CA 15-3 and circulating tumor cells were detected in 21 of 27 women (78%) and 26 of 30 women (87%), respectively. Circulating tumor DNA levels showed a greater dynamic range, and greater correlation with changes in tumor burden, than did CA 15-3 or circulating tumor cells. Among the measures tested, circulating tumor DNA provided the earliest measure of treatment response in 10 of 19 women (53%). Conclusions This proof-of-concept analysis showed that circulating tumor DNA is an informative, inherently specific, and highly sensitive biomarker of metastatic breast cancer. (Funded by Cancer Research UK and others.).New England Journal of Medicine 03/2013; 368(13). DOI:10.1056/NEJMoa1213261
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ABSTRACT: Congenital myasthenic syndromes are a heterogeneous group of inherited disorders that arise from impaired signal transmission at the neuromuscular synapse. They are characterized by fatigable muscle weakness. We performed linkage analysis, whole-exome and whole-genome sequencing to determine the underlying defect in patients with an inherited limb-girdle pattern of myasthenic weakness. We identify ALG14 and ALG2 as novel genes in which mutations cause a congenital myasthenic syndrome. Through analogy with yeast, ALG14 is thought to form a multiglycosyltransferase complex with ALG13 and DPAGT1 that catalyses the first two committed steps of asparagine-linked protein glycosylation. We show that ALG14 is concentrated at the muscle motor endplates and small interfering RNA silencing of ALG14 results in reduced cell-surface expression of muscle acetylcholine receptor expressed in human embryonic kidney 293 cells. ALG2 is an alpha-1,3-mannosyltransferase that also catalyses early steps in the asparagine-linked glycosylation pathway. Mutations were identified in two kinships, with mutation ALG2p.Val68Gly found to severely reduce ALG2 expression both in patient muscle, and in cell cultures. Identification of DPAGT1, ALG14 and ALG2 mutations as a cause of congenital myasthenic syndrome underscores the importance of asparagine-linked protein glycosylation for proper functioning of the neuromuscular junction. These syndromes form part of the wider spectrum of congenital disorders of glycosylation caused by impaired asparagine-linked glycosylation. It is likely that further genes encoding components of this pathway will be associated with congenital myasthenic syndromes or impaired neuromuscular transmission as part of a more severe multisystem disorder. Our findings suggest that treatment with cholinesterase inhibitors may improve muscle function in many of the congenital disorders of glycosylation.Brain 03/2013; 136(Pt 3):944-56. DOI:10.1093/brain/awt010
Article: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.[Show abstract] [Hide abstract]
ABSTRACT: Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer (CRC) have no detectable germline mutations in the known cancer predisposition genes. Using whole-genome sequencing, supplemented by linkage and association analysis, we identified specific heterozygous POLE or POLD1 germline variants in several multiple-adenoma and/or CRC cases but in no controls. The variants associated with susceptibility, POLE p.Leu424Val and POLD1 p.Ser478Asn, have high penetrance, and POLD1 mutation was also associated with endometrial cancer predisposition. The mutations map to equivalent sites in the proofreading (exonuclease) domain of DNA polymerases ɛ and δ and are predicted to cause a defect in the correction of mispaired bases inserted during DNA replication. In agreement with this prediction, the tumors from mutation carriers were microsatellite stable but tended to acquire base substitution mutations, as confirmed by yeast functional assays. Further analysis of published data showed that the recently described group of hypermutant, microsatellite-stable CRCs is likely to be caused by somatic POLE mutations affecting the exonuclease domain.Nature Genetics 12/2012; DOI:10.1038/ng.2503
Article: Recessive Mutations in SPTBN2 Implicate β-III Spectrin in Both Cognitive and Motor Development.[Show abstract] [Hide abstract]
ABSTRACT: β-III spectrin is present in the brain and is known to be important in the function of the cerebellum. Heterozygous mutations in SPTBN2, the gene encoding β-III spectrin, cause Spinocerebellar Ataxia Type 5 (SCA5), an adult-onset, slowly progressive, autosomal-dominant pure cerebellar ataxia. SCA5 is sometimes known as "Lincoln ataxia," because the largest known family is descended from relatives of the United States President Abraham Lincoln. Using targeted capture and next-generation sequencing, we identified a homozygous stop codon in SPTBN2 in a consanguineous family in which childhood developmental ataxia co-segregates with cognitive impairment. The cognitive impairment could result from mutations in a second gene, but further analysis using whole-genome sequencing combined with SNP array analysis did not reveal any evidence of other mutations. We also examined a mouse knockout of β-III spectrin in which ataxia and progressive degeneration of cerebellar Purkinje cells has been previously reported and found morphological abnormalities in neurons from prefrontal cortex and deficits in object recognition tasks, consistent with the human cognitive phenotype. These data provide the first evidence that β-III spectrin plays an important role in cortical brain development and cognition, in addition to its function in the cerebellum; and we conclude that cognitive impairment is an integral part of this novel recessive ataxic syndrome, Spectrin-associated Autosomal Recessive Cerebellar Ataxia type 1 (SPARCA1). In addition, the identification of SPARCA1 and normal heterozygous carriers of the stop codon in SPTBN2 provides insights into the mechanism of molecular dominance in SCA5 and demonstrates that the cell-specific repertoire of spectrin subunits underlies a novel group of disorders, the neuronal spectrinopathies, which includes SCA5, SPARCA1, and a form of West syndrome.PLoS Genetics 12/2012; 8(12):e1003074. DOI:10.1371/journal.pgen.1003074
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ABSTRACT: By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing. By developing methods to integrate information across several algorithms and diverse data sources, we provide a validated haplotype map of 38 million single nucleotide polymorphisms, 1.4 million short insertions and deletions, and more than 14,000 larger deletions. We show that individuals from different populations carry different profiles of rare and common variants, and that low-frequency variants show substantial geographic differentiation, which is further increased by the action of purifying selection. We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites. This resource, which captures up to 98% of accessible single nucleotide polymorphisms at a frequency of 1% in related populations, enables analysis of common and low-frequency variants in individuals from diverse, including admixed, populations.Nature 11/2012; 491(7422-7422):56-65. DOI:10.1038/nature11632
Article: Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns[Show abstract] [Hide abstract]
ABSTRACT: Chronic lymphocytic leukaemia (CLL) is characterized by relapse after treatment and chemotherapy resistance. Like in other malignancies, leukaemia cells accumulate mutations during growth, forming heterogeneous cell populations that are subject to Darwinian selection and may respond differentially to treatment. There is therefore a clinical need to monitor changes in the subclonal composition of cancers during disease progression. Here, we use whole-genome sequencing (WGS) to track subclonal heterogeneity in three CLL patients subjected to repeated cycles of therapy. We reveal different somatic mutation profiles in each patient and use these to establish likely hierarchical patterns of subclonal evolution, to identify subclones that decline or expand over time, and to detect founder mutations. We show that clonal evolution patterns are heterogeneous in individual patients. We conclude that genome sequencing is a powerful and sensitive approach to monitor disease progression repeatedly at the molecular level. If applied to future clinical trials- this approach might eventually influence treatment strategies as a tool to individualise and direct cancer treatment.Blood 08/2012; 120(20). DOI:10.1182/blood-2012-05-433540
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ABSTRACT: The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-genome and exome sequencing followed by innovative tumorgraft analyses (to accurately determine mutant allele ratios) identified several putative two-hit tumor suppressor genes, including BAP1. The BAP1 protein, a nuclear deubiquitinase, is inactivated in 15% of clear cell RCCs. BAP1 cofractionates with and binds to HCF-1 in tumorgrafts. Mutations disrupting the HCF-1 binding motif impair BAP1-mediated suppression of cell proliferation but not deubiquitination of monoubiquitinated histone 2A lysine 119 (H2AK119ub1). BAP1 loss sensitizes RCC cells in vitro to genotoxic stress. Notably, mutations in BAP1 and PBRM1 anticorrelate in tumors (P = 3 × 10(-5)), and combined loss of BAP1 and PBRM1 in a few RCCs was associated with rhabdoid features (q = 0.0007). BAP1 and PBRM1 regulate seemingly different gene expression programs, and BAP1 loss was associated with high tumor grade (q = 0.0005). Our results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities.Nature Genetics 06/2012; 44(7):751-9. DOI:10.1038/ng.2323
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ABSTRACT: Most anticancer drugs entering clinical trials fail to achieve approval from the U.S. Food and Drug Administration. Drug development is hampered by the lack of preclinical models with therapeutic predictive value. Herein, we report the development and validation of a tumorgraft model of renal cell carcinoma (RCC) and its application to the evaluation of an experimental drug. Tumor samples from 94 patients were implanted in the kidneys of mice without additives or disaggregation. Tumors from 35 of these patients formed tumorgrafts, and 16 stable lines were established. Samples from metastatic sites engrafted at higher frequency than those from primary tumors, and stable engraftment of primary tumors in mice correlated with decreased patient survival. Tumorgrafts retained the histology, gene expression, DNA copy number alterations, and more than 90% of the protein-coding gene mutations of the corresponding tumors. As determined by the induction of hypercalcemia in tumorgraft-bearing mice, tumorgrafts retained the ability to induce paraneoplastic syndromes. In studies simulating drug exposures in patients, RCC tumorgraft growth was inhibited by sunitinib and sirolimus (the active metabolite of temsirolimus in humans), but not by erlotinib, which was used as a control. Dovitinib, a drug in clinical development, showed greater activity than sunitinib and sirolimus. The routine incorporation of models recapitulating the molecular genetics and drug sensitivities of human tumors into preclinical programs has the potential to improve oncology drug development.Science translational medicine 06/2012; 4(137):137ra75. DOI:10.1126/scitranslmed.3003643
Top Journals
- Genomics (19)
- Nature (17)
- Nature (16)
- Nucleic Acids Research (9)
- Human Molecular Genetics (7)
University College LondonLondinium, England, United Kingdom
Cancer Research UK Cambridge InstituteCambridge, England, United Kingdom
Umeå UniversityUmeå, Västerbotten, Sweden
NIHR Oxford Biomedical ResearchOxford, England, United Kingdom
Wellcome Trust Sanger Institute
Cambridge, England, United Kingdom
- Cancer Genome Project
IlluminaIsle of Palms, South Carolina, United States
Imperial College LondonLondinium, England, United Kingdom
University of Oxford
Oxford, ENG, United Kingdom
- Wellcome Trust Centre for Human Genetics
University of Cambridge
Cambridge, ENG, United Kingdom
- Department of Haematology
Institute of Genetics and Molecular MedicineEdinburgh, Scotland, United Kingdom
Saint Louis ZooSan Luis, Missouri, United States


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Mesa HotelsDiscover upmarket shopping at swanky megamalls, tuck into authentic Bavarian cuisine in one of many ethnic restaurants, and cozy up to arts and culture in endless galleries and museums. Mesa is more than a rambling exurbia. It's a vibrant, multi-cultural community packed full of exciting attractions, from the rocky heights of mountain parks that graze its borders, to the sprawling fairways of its popular championship golf courses. It's bustling by day, hectic streets crammed with locals heading to work, and just as busy at night when entertainments districts come to life with pulsating music drifting from buzzing bars.Things to seeLike a verdant oasis in the desert, the famous Rose Garden at Mesa Community College is a lush and fertile haven filled with the colorful blooms of over 9,000 rose bushes. This little patch of paradise is open to the public who are welcome to stroll its meandering walkways, while here and there local students study plants in their natural habitat. Over at the Superstition Springs Center you'll find some of Mesa's most popular shopping all under one roof. Glittering diamonds adorn the window of a popular jewelry store, the scent of bespoke bath salts fills the air from beauty salons, and the food hall is packed with restaurants of all types, from tasty Thai to sizzling Spanish. You can spend hours here, wandering through the cool air-conditioned galleries and exploring fashionable clothing stores. At the Arizona Museum for Youth, more commonly known as AMY, it's what the kids think that really matters. Permanent exhibitions of artworks adorn the walls, interactive areas with smartboards and activities are popular with kids under 4, and don't think children under 12 don't appreciate fine art – by the looks of these multi-colored, hands-on workshops, they absolutely love it.Hotels in MesaA sprawling suburb of Phoenix, there are plenty of hotels in Mesa for all types of travelers. The majority fit into a mid-budget range, providing spacious bedrooms with cable or satellite channels, microwaves, irons, and complimentary high speed internet access as well. Nearly every hotel, regardless of its star rating has a pool – it's almost essential in this hot southern state. If you're in the market for something higher priced, you won't find many luxury hotels in Mesa, it's definitely more of a student vibe. By traveling a little further north into the neighboring town of Scottsdale, all that changes. Within walking distance of the Echo Canyon Park and a short drive from the Phoenix Mountains Preserve are some fabulous hotels with elegant furnishings, decadent bathrooms, and idyllic mountain views you won't want to leave behind.Where to stayMesa is a sprawling town, almost entirely swallowed by the ever-expanding suburbs of Phoenix. The vast length of Superstition Freeway cuts straight through the center, while the aptly named Red Mountain Freeway hugs the winding banks of Salt River as it trails away from the heights of the Four Peaks Wilderness. Its broad Main Street is lined with famous fast food joints and independent U-Haul contractors, discount hotels, automobile forecourts crammed with shiny new cars, and cozy motels indicated by neon-bright signs.How to get to MesaThe Phoenix Sky Harbor International Airport is literally just the other side of Salt River from the built-up streets of Mesa. It's perfectly located for easy onward travel by taxi, hire car, or bus, and an express route connects the airport to many of the hotels in Mesa. While you're in the city, the light rail route makes discovering the town easy and convenient, with stops close to its most popular cultural sights and shopping locales.
Hotels in Mesa
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Ramada Mesa Phoenix East Area
Good 3.4 / 5 ( 830 reviews )
155 people looked at this hotel in the last hour
Most recent review
"After a very disappointing stay at another hotel in the city, we found the Ramada. It was very clean and comfortable. The hotel staff was very friendly and helpful. It was about a mile from a mall that had fast food service late at night. The breakfast the next morning was wonderful. The price wa..."
A Traveller, Jun 2015, US
Mesa Mezona Inn
Good 3.8 / 5 ( 444 reviews )
57 people looked at this hotel in the last hour
Most recent review
"We stayed two nights and it was great. A big room with a king bed, couch and flat panel tv with good reception. The breafast was also very good with something different each morning. It had a big nice clean pool. I can't say enough good things about this hotel. I don't know why it's o..."
A Traveller, Jun 2015, US
Best Western Plus Mesa
Excellent 4.1 / 5 ( 220 reviews )
56 people looked at this hotel in the last hour
Most recent review
"It was a excellent place, right by the freeway easy access. And the hot breakfast each morning was great. Definitely staying here again next time I'm in town."
A Traveller, Jul 2015, US
Best Western Legacy Inn & Suites
Excellent 4.2 / 5 ( 472 reviews )
51 people looked at this hotel in the last hour
Most recent review
"Room was very nice and large. this was our second visit. My husband really enjoys the breakfasts, especially the biscuits and gravy. My only complaint is that the doors are so hard to open and very heavy. I don't see how an elderly person could manage. Neighborhood is convenient to many resta..."
A Traveller, Jul 2015, US
Arizona Golf Resort & Conference Center
Good 3.6 / 5 ( 611 reviews )
50 people looked at this hotel in the last hour
Most recent review
"Came to arizona for a wedding. Room was clean beds were very comfortable. Friendly staff. Would stay again"
A Traveller, May 2015, US
Hyatt Place Phoenix/Mesa
Outstanding 4.7 / 5 ( 372 reviews )
49 people looked at this hotel in the last hour
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"Nice hotel, lovely staff, and the breakfast was decent!"
A Traveller, Jul 2015, US
Days Hotel Mesa Near Phoenix
Excellent 4.3 / 5 ( 576 reviews )
47 people looked at this hotel in the last hour
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"Best staff any where. Young ladies at the front desk take amazing care of you."
A Traveller, Jun 2015, US
Days Inn And Suites Mesa
Fair 2.8 / 5 ( 212 reviews )
42 people looked at this hotel in the last hour
Most recent review
"Everything is ok except the air conditioning is so loud"
A Traveller, Jun 2015, US
Phoenix Mesa Marriott
Excellent 4.2 / 5 ( 351 reviews )
28 people looked at this hotel in the last hour
Most recent review
"The hotel property is excellent...the neighborhood is "emerging" as we call it up here. My sister and I came down to attend Spring Training and this property was the most reasonably priced; we'd stay here again for sure. I always seek out Marriott properties because the beds are soo..."
A Traveller, Jun 2015, US
Knights Inn Mesa Az
Fair 2.2 / 5 ( 325 reviews )
17 people looked at this hotel in the last hour
Most recent review
"poor service , no shampoo and other's inside room, clean but smelly...."
A Traveller, Mar 2015, US

subset: commoncrawl


text:
A History of My Times: History of My Times: (Hellenica)Paperback Penguin Classics Language: English / Greek, Ancient (to 1453)
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- Publisher: PENGUIN CLASSICS
- Format: Paperback | 432 pages
- Language: English / Greek, Ancient (to 1453)
- Dimensions: 127mm x 196mm x 23mm | 272g
- Publication date: 31 May 1979
- Publication City/Country: London
- Edition statement: Revised ed.
- Illustrations note: notes, maps
- Sales rank: 36,654
Product description
Xenophon's "History" recounts nearly fifty turbulent years of warfare in Greece between 411 and 362 BC. Continuing the story of the Peloponnesian War at the point where Thucydides finished his magisterial history, this is a fascinating chronicle of the conflicts that ultimately led to the decline of Greece, and the wars with both Thebes and the might of Persia. An Athenian by birth, Xenophon became a firm supporter of the Spartan cause, and fought against the Athenians in the battle of Coronea. Combining history and memoir, this is a brilliant account of the triumphs and failures of city-states, and a portrait of Greece at a time of crisis.
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Author information
Xenophon was an Athenian gentleman born in the early 420s BC. He was a fine officer and leader for Athens, but his support of Socrates led to his banishment. He lived under the protection of Sparta on an estate near Olympia, where he began to write his histories and memoirs. Rex Warner was a Professor at the University of Connecticut. He taught in Egypt and England and was Director of the British Institute in Athens. He died in 1986. George Cawkwell is a Fellow Emeritus of University College, Oxford. He has specialised in the history of Greece from the sixth to the fourth century BC.
Table of contents
A History of My TimesIntroduction Select Bibliography A Note on the Notes A History of My Times Book One Book Two Book Three Book Four Book Six Book Seven Appendix Maps: 1. The Aegean 2. Asia Minor 3. Northern Peloponnese and North West Greece 4. Central Greece 5. Area of the Isthmus and the Saronic Gulf 6. Central and Southern Peloponnese 7. Chalcidice Index


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The College of St. Scholastica CLEAN Equip Student Agreement
This Agreement is a mandatory step in the CLEAN admission process and adherence to the outlined expectations it includes is paramount to active membership in the CLEAN Program and participation in CLEAN Equip. It is pertinent to both on-campus residents and non-residents. Only those who have signed with an understanding of terms and conditions of CLEAN membership are eligible for receiving the financial and programmatic benefits offered by the program.
First and foremost, I will engage the CLEAN Community meeting and continually strive to further my role as a member of that community. My purpose here must remain clear: to utilize the recovery community and the resources, service opportunities, and support offered to me.
I will put in time and effort with CLEAN members outside of formal and mandatory CLEAN events to develop a relationship with other members of the community.
I will reach out to fellow community members in both my time of need and in theirs so that we may support one another.
I will hold my fellow community members accountable and will expect them to do the same for me.
I will stay current with CLEAN staff members, practicing the four principles of honesty, transparency, servant-hood, and accountability in those relationships, recognizing that their sole purpose is to help me further develop a recovery lifestyle.
I will attend a formal meeting with staff once per semester (or more if needed and requested by staff) to evaluate my role and level of engagement in the CLEAN community.
I will commit to attending the weekly CLEAN Community meeting, understanding that my presence at this is an essential testament to my dedication to and respect for my peers.
I will continue to commit to and enhance my own recovery program understanding that it is my responsibility.
I will participate in CLEAN Programming and events, making an effort to attend recreational community building events to connect with peers and demonstrate my commitment to the community.
I will look for ways to be of service to the community such as driving CSS-issued vehicles to twelve-step meetings and events, speaking in classes, spearheading fun events for community members, and seeking out those in the community in need of support.
I will not ingest or be in possession of alcohol or any illegal or mind or mood-altering substances
(Only legitimately prescribed drugs may be possessed and ingested after being approved by a physician with whom SCHAWB staff will be, if necessary, in continuous contact. This may require you to sign a release of information with this care provider).
I will not partake in a romantic and/or physical relationship with any other CLEAN peer group member during my first semester on CLEAN contract and my first year of sobriety. Relationships between CLEAN members must follow the aforementioned protocol and also be disclosed to and discussed with staff. Pre-existing relationships between CLEAN students must also be disclosed to and discussed with staff upon acceptance into CLEAN.
I will adhere to the AA/NA legacy of honesty, open-mindedness, and willingness.
I will attend a minimum of three Twelve Step meetings each week. Attendance to Non-Twelve Step meetings can be discussed with staff.
I will develop and maintain a firm and truthful relationship with a sponsor, meeting regularly with that individual and actively progressing in my recovery through our work together.
I will attend class and maintain status as a full-time student or employee, keeping in mind that my primary purpose here is to succeed academically.
I will not attend bars, casinos, strip clubs, or other high-risk environments unless previously discussed with my peers and a CLEAN staff member.
When on the CSS campus, I will adhere to and respect all college policies and values as outlined in the handbook.
I will meet bi-weekly with the CLEAN Recovery Coach and invest in those sessions by being mindful, willing to take action, and honest in those discussions.
I will agree to take urinalysis tests as requested by CLEAN staff, cooperating with the process and adhering to a policy of strict honesty and sobriety and understanding that failure of a urinalysis test is grounds for dismissal from the program and exclusion from the offered stipend. Please see attached UA policy.
I will serve as a positive influence and contributor to the CLEAN Program and its members, treating all participants with respect.
The College of St. Scholastica CLEAN Reside Housing Student Agreement
This agreement outlines the rules and expectations associated with residing in The College of St. Scholastica Recovery Services' CLEAN Program sober living community. The content of this agreement supplements the rules defined by Residential Life through the College Student Handbook and the Residential Life Housing Contract. All Residential Life policies apply to residents in CLEAN Reside and compliance with these policies is essential. It is your responsibility to familiarize yourself with the rules Residential Life has defined in the Housing Contract and Student Handbook.
I will conduct myself in a manner that reflects the higher standard to which I am held as a member of the CLEAN Reside sober living community.
I will not use or be in possession of alcohol or other drugs while living in CLEAN Reside. I understand that if I am found to be under the influence of drugs or alcohol I will be asked to leave the community immediately and return only at the discretion of CLEAN staff. See dismissal protocol.
I will attend the weekly house meeting in addition to all other Equip programming and events.
Residential Life policies:
I will adhere to all Residential Life policies.
I will respect the college's tobacco policy; refraining from tobacco use on campus.
I will adhere to the expectations set by my Residential Advisor (RA).
I will respect the no-pet policy, the only exception being fish or a written exception approved by disability services and Residential Life.
Guest and leaves:
I understand that overnight guests outside of the CLEAN Program are not allowed unless approved by the house manager prior to the arrival of that outside guest. Approval must be clearly vocalized or documented by the house manager.
I will not engage in sexual activity in the apartments.
If I am to spend the night elsewhere, I need to inform my roommates and house manager before 11 pm of that evening.
Respect for living space:
I will cooperate with the house manager in weekly apartment inspections to ensure that my residence is up to cleanliness standards. If necessary, I will respect and complete my weekly chores as assigned and agreed upon during house meetings.
I will respect shared space and communicate well with my roommate(s) to avoid conflict and discourteous behavior as much as possible, utilizing the house manager and/or RA in facilitating the resolution of more serious disputes as they arise.
I will not attend casinos unless authorized by CLEAN staff prior to my visit. I will not attend strip clubs.
I will keep any prescribed medication in a safe location and in the container issued by the pharmacy. I will disclose these medications to the house manager immediately.
I understand that at any time the apartment may be searched in its entirety by staff or representatives of The College of St. Scholastica.
Please see attached UA Policy as it applies to CLEAN Reside.
I will utilize the house manager and respect him or her as a resource and staff member of The College of St. Scholastica. I will abide by the accountability offered by both the house manager and my peers.
I will hold my roommates and Reside neighbors accountable as appropriate. I understand that covering up for them is participating in dishonesty and is therefore a violation of the integrity of the community.
I understand that this housing contract is an addition to and not replacement of the general CLEAN Equip Student Agreement.
I understand that I have waived my right of Due Process and that in the event of an eviction, alternate housing is not guaranteed.
I understand that subleasing is at the discretion of Residential Life. Unlike traditional sublets, Residential Life will have to determine if there is a space available if another party is interested in subleasing. CLEAN residences cannot be occupied by those not accepted into the CLEAN program; therefore, any potential subleaser will need to be approved by both CLEAN and Residential Life staff.
I specifically agree that if I violate any of the expectations outlined or implied by this contract, I can be expelled from the The College of St. Scholastica housing and forfeit any rights to my deposit and fees agreed upon in the Residential Life housing contract.
I understand that this is a general list of expectations and that representatives of The College of St. Scholastica may at any time make decisions regarding my presence in or dismissal from the sober living community based on their determination of appropriate behavior.
I understand that in the event of eviction, I will not be refunded any rent or deposit paid to The College of St. Scholastica.
I understand that if removed from the Reside sober living community, there may not be on-campus housing available and that in this event, I would be responsible for securing and funding off-campus housing.
I understand that if I am not a St. Scholastica student and am removed from the Reside sober living community, I will not be offered traditional on-campus housing.
I agree that final determination for any disciplinary action will be at the discretion of The College of St. Scholastica Vice President of Student Affairs or Dean of Students.
Just as it is expected of any student attending CSS, all Clean Reside students are expected to be aware of and uphold all policies and guidelines as outlined in the CSS Student Handbook and Residential Life Handbook - found here: http://css.edu/studenthandbook
I am currently of sound mind and not under the influence of any drugs or alcohol.
I understand that violations of these expectations can result in my dismissal from housing or the CLEAN Program in general.
3 strike rule: If I violate any one of these expectations three times throughout the academic year, I will be dismissed from CLEAN Reside and possibly campus housing in general. Major policy violations may warrant more serious consideration for dismissal by CLEAN or Residential Life staff.
By signing this agreement, I hereby pledge to adhere to all terms and conditions aforementioned. I understand that any violation of one or more of these stipulations is grounds for review and immediate dismissal. I understand that my role in CLEAN is conditional of, and epitomized by, following this agreement.
This contract is effective ________________ until _________________
Printed name of Agreement holder
Signature of Agreement holder
Signature of Recovery Services representative
CSS Student Affairs
Recovery Services – CLEAN
CLEAN Reside Supplemental Agreement
Rev: 18.104.22.168
In-Take Punch List:
1. Review CLEAN Equip and Housing Supplemental Agreement and sign
2. If outstanding, complete "Housing Application Form"
3. Fill out following forms:
a. Permanent address / emergency contact
b. Continuing care release of information
4. Confirm with Residential Life that key and ID are available
5. Provide Area Meeting Guide and review frequently attended meetings
6. Notify RA of new resident
CSS Student Affairs
Recovery Services – CLEAN
CLEAN Reside Supplemental Agreement
Rev: 126.96.36.199
Additional Notes specific to Non-Student Residents
BILLING – Unlike traditional rent; all charges incurred for housing, meal-plans and parking are posted to your "student account" and must be current at the end of each semester in order to remain in housing. There are a number of payment plan options and Deb Olsen in the Business Office can be contacted for information on these, as well as updated account balance information.
Deb Olson
email@example.com (218) 723-6292
IT IS YOUR RESPONS ILITY to understand your account balance and payment terms.
PARKING - A parking pass can be purchased from the business office as follows:
1) Email Barb Hohl [firstname.lastname@example.com] and provide the following -
a) First and Last Name
b) School ID [B000#####]
c) Automobile make and model
d) Automobile license plate information
2) You will also need to tell her that you are a NON STUDENT RESIDENT residing in Pine Apartments, in the sober living community and that she can contact Ben Bertsch with Student Affairs if she has any questions. The parking permit will be added to your account.
MAIL – A mailbox can be assigned to you as follows:
1) At the mailroom customer service window in the Student Union, ask for Keith Haugen
2) Tell Keith you are a NON STUDENT RESIDENT living in Pine Apartments, in the sober living community and you would like information on having mail delivered to you at CSS.
3) Your mailing address will be as follows:
1200 Kenwood Avenue
Duluth, MN 55811
CSS Student Affairs
Recovery Services – CLEAN
CLEAN Reside Supplemental Agreement
Rev: 22.214.171.124
Page 12 of 12
INTERNET SERVICE - Two computers are available for your use in T2750 during office hours [8am-4pm M-F] or as arranged. If you have a personal computer, information on accessing the Internet is as follows:
Welcome to wireless access at The College of St. Scholastica [http://www.css.edu/Administration/Information-Technologies/Wireless-Network.html]
The network is known as Storm's Wireless Network. You will see this on your wireless laptop computer as "stormswirelessnet". Storm's Wireless Network allows users with a wireless laptop computer or PDA to access their K and R drives, Google Apps (e-mail), Banner Web, WebCT and the internet. Storm's wireless network is an 802.11b /g network.
Storm's Wireless Network is available to any student, staff, or faculty member with a valid network user id and password. To connect to Storm's Wireless Network you need to have an 802.11b or 802.11g compatible wireless network card in your laptop or PDA. If you use either a Microsoft Windows laptop or Mac you must also download and install a piece of software called Cisco Clean Access Agent.
For non-student residents; login as Clean. The password is changed regularly and an updated password can be provided by Recovery Services Staff.


text:
3 police shootings occur day of Philly review request
The day its police commissioner said he is seeking a review of the department's use of deadly force, Philly police were involved in 3 shootings
Associated Press
PHILADELPHIA — Philadelphia police shot and killed a suspect during a gun battle Wednesday night, marking the third police-involved shooting in the city on the day its police commissioner said he is seeking a review of the department's use of deadly force.
The latest shooting happened in the city's Germantown section while officers were pursuing at least three suspects, authorities said. A 2-year-old boy also suffered a graze wound during the exchange. Officers were searching for the remaining suspects.
It was the third police-involved shooting in the city on Wednesday and came hours after the police Commissioner Charles Ramsey announced that he is seeking an independent review of the department's deadly force policies. Earlier in the day officers shot a man in the buttocks after police say he pointed a gun; another man was critically injured after he was shot by officers who said he fired at them.
Ramsey cited similar reviews done for the Las Vegas and New York police departments by CNA Analysis and Solutions and the RAND Firearm Evaluation group that had led the departments to adopt new training curriculums and new or revised policies. Ramsey said he had reached out to the federal Department of Justice's Office of Community Oriented Policing Services to secure funding and assistance for a review of Philadelphia police practices, training and policies on police-related shootings.
In a letter on the department's Facebook page, Ramsey said the study was not an audit or investigation.
"Consulting with an independent party will ensure credibility and an objective view in this process of evaluating our policies and procedures," he wrote. "My primary concern is the sanctity of life equally for members of this department and the public we serve. At no point am I looking to compromise the safety of our officers."
However, he wrote that it's important to be sure that the department is using best practices.
"Utilizing the resources available to our police department to enhance the department is an intelligent and responsible decision, one that is owed to the public and the members of the department," he wrote.
Copyright 2013 Associated Press
Copyright 2015 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Recommended Use of Force
Austin police kill man suspected of slaying 1 in hotel lobby
Union denounces release of officer names in police shootings
Police warn public against using iPhone cases shaped like guns
FBI: No civil rights violations in Calif. shooting of teen carrying replica AK-47
Witness: Man killed in controversial Wash. OIS told cops 'shoot me'
Join the discussion
PoliceOne top 5
- 1 10 secrets cops know that most people don't
- 2 Video: Ariz. shootout injures two cops, kills suspect
- 3 Video: Texas cops fatally shoot man who pulled replica
- 4 Video: Cops, medic, firefighters brawl at T-ball game
- 5 Former LA cop involved in OIS shares lessons on deadly force


text:
Light Mashed Potatoes
Fat-free half-and-half gives these potatoes the same silky texture you'd get with heavy cream but without the fat and cholesterol.
Total Time:
Level: Easy
Yield: 6 side-dish servings
Serves: 6
Advertisement - Continue Reading Below
- 2 lb. Yukon gold potatoes
- 1 tbsp. margarine or butter
- 0.75 tsp. salt
- 0.50 c. fat-free half-and-half
- In 4-quart saucepan, combine potatoes and enough water to cover; heat to boiling on high. Reduce heat to low; cover and simmer 8 to 10 minutes or until potatoes are fork-tender. Reserve 1/4 cup cooking water; drain potatoes.
- Return potatoes to saucepan. Mash with margarine and 3/4 teaspoon salt. Gradually add warm half-and-half, continuing to mash potatoes until smooth and well blended; add reserved cooking water if necessary. Transfer to serving dish. Makes about 4 1/2 cups.
From: Good Housekeeping
What do you think?
18 Slider Recipes So Good You'll Want One of Each
Pair these mini burgers with a flight of beers and you are SET.
7 Dixie-Cup Popsicles You Cannot Fail at Making
No fancy molds or kitchen gadgets necessary.
Make It A Star!
11 star-shaped things, from pizza to Pop-Tarts. Because are you American or not?
More From Meals & Cooking


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
31 year old woman | Centennial, CO, USA | Seeking men 26-45 within 25 miles of Englewood, CO
experience is not what happens to a man; it is what a man does with what happens to him.
i'm not going to be your typical denver girl, for one i can't stand dubstep :) but i am a tomboy, and i do prefer to wear sandals to heels. i'm a nurse, and i love what i do, so if you're going to hate hearing about gruesome ER stories, look elsewhere for a date. i'm a colorado native, and i love it here, but i'd like to find someone i could explore with, both CO and beyond. and yes, i love shopping but i'll never ask you to come with me, and i really love eating out, but i'm perfectly happy staying home and cooking too. a girlfriend of mine describes my political views as, "smart" not liberal or conservative. I thought that was kind of adorable, but also pretty accurate, you have been warned. oh, and if you're a compulsive sports junkie it's probably not going to work out. if, however, you're a compulsive NPR/Frontline type, we'll get along swimmingly. i'm very into yoga and mindfulness, i've signed up for my first round of teacher training starting next month, and i'm pretty excited to get started after over a decade of practice. a quote i heard in class recently that's stuck with me, "learning without reflection is a waste, and reflection without learning is dangerous" also to think of every relationship as an experiment, some are successful, and some are not.
Billiards / Pool, Cycling, Dancing, Golf, Martial arts, Other types of exercise, Skiing, Tennis / Racquet sports, VolleyBall, Walking / Hiking, Weights / Machines, Yoga
I exercise 3-4 times per week.
I like Cats, Dogs, Horses
mizuna, trillium, root down, city o city, wash perk, D Bar, osteria marco
david sedaris, let's talk about diabetes with owls Game of thrones book 4
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'7" (170cms)
|5'9" (175cms) to 6'5" (195cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned
|No preference
|No preference
|No Way
|No Way, Occasionally
|Social Drinker
|Social Drinker, Regularly, Moderately
|Medical / Dental / Veterinary / Fitness
|No preference
|$50,001 to $75,000
|No preference
|Never Married
|No preference
|Have kids:
|No preference
|Wants kids:
|I'll tell you later
|No preference
|White / Caucasian
|No preference
|No preference
|English, Spanish
|No preference
|Bachelors degree
|Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


text:
Audio Samples
Album Summary
- Mario Zanasi (Baritone)
- Veriano Luchetti (Tenor)
- Mietta Sighele (Soprano)
Notes & Reviews:
Puccini's first opera, Le villi, was premiered in 1884 on a triple bill with two other short works now forgotten. It was the surprise hit of the evening, but the little opera's appeal was not long lasting-it soon disappeared from world stages except for occasional presentation as a novelty once Puccini was more famous for other works. Live performance, Florence, February 4, 1972.
ReviewsThere are currently no reviews, be the first one!
Also Purchased
Works DetailsPuccini, Giacomo : Le Villi
- Performers: Mario Zanasi (Baritone); Veriano Luchetti (Tenor); Mietta Sighele (Soprano)
- Conductor: Hans Ratjen
- Running Time: 26 min. 14 sec.
- Period Time: Post Romantic
- Form: Opera/Operetta
- Written: 1884
- Studio/Live: Live


text:
Cardinals making offer to Cuban SS Aledmys Diaz
Feb 19, 2014, 7:37 PM EDT
Joe Strauss of the St. Louis Post-Dispatch has the story from Cardinals spring training in Jupiter, Florida …
Long after the clubhouse emptied, general manager John Mozeliak and his chief lieutenants, manager Mike Matheny and coaches from both sides of camp attended a workout of Cuban shortstop Aledmys Diaz, who is expected to sign a major-league contract with a club within days.
The Cardinals are expected to follow up on their longstanding interest in the 23-year-old by extending a formal offer to his agent, Jaime Torres, within the next 24 hours.
The Cardinals signed shortstop Jhonny Peralta to a four-year, $53 million free agent contract in November and are set at third base with Matt Carpenter and at second base with Kolten Wong. But the word on Diaz is that his defense needs fine tuning, so the St. Louis front office could be thinking long term with this move.
The Yankees, Blue Jays, Mariners, Padres, and Giants are also known to have interest in Diaz, who hit .315/.404/.500 with 12 home runs and 11 stolen bases in 313 plate appearances his final year in Cuba.
Patrick Corbin to start for the Diamondbacks on Saturday
Jul 3, 2015, 8:35 PM EDT
Patrick Corbin will complete his long trek back to the major leagues when he starts against the Rockies on Saturday.
Josh Reddick expressed unhappiness with his playing time in a radio interview, then apologized
Jul 3, 2015, 7:45 PM EDT
The Athletics haven't used Josh Reddick much against left-handed starters. Reddick isn't too happy with that, despite his results against southpaws.
Pirates prospect Jameson Taillon to miss two months due to hernia surgery
Jul 3, 2015, 6:55 PM EDT
Jameson Taillon was getting pretty close to returning to action for the Pirates, but an inguinal hernia has knocked him back on the shelf.
Cubs acquire Clayton Richard from the Pirates for cash considerations
Jul 3, 2015, 6:05 PM EDT
The Cubs acquired Clayton Richard from the Pirates and he'll start for the club on Saturday.
Brewers bullpen catcher sets the cheesesteak-eating record at Citizens Bank Park
Jul 3, 2015, 4:40 PM EDT
The Blue Jays are interested in Jeff Samardzija
Jul 3, 2015, 3:52 PM EDT
Both he and the White Sox have disappointed this year, but he could help a contender.
The Tigers have designated Joba Chamberlain and Tom Gorzelanny for assignment
Jul 3, 2015, 3:11 PM EDT
Chamberlain has posted a 4.09 ERA and an ugly 1.682 WHIP in 30 appearances this year. Gorzelanny has been even worse.
The Yankees, A-Rod resolve their dispute over the $6 million milestone bonus
Jul 3, 2015, 2:13 PM EDT
$3.5 million will be paid out . . . to charity.
Travis Ishikawa designated for assignment by the Giants. Again.
Jul 3, 2015, 2:05 PM EDT
He's only had six plate appearances since being recalled in late June.
Bruce Bochy is the best overall manager; Joe Maddon is the one players would like to play for
Jul 3, 2015, 1:00 PM EDT
And, someone, Tony La Russa placed in this thing.
Yankees donate $150,000 to charity to get Alex Rodriguez his 3,000th hit ball
Jul 3, 2015, 11:37 AM EDT
He changed his mind.
Mike Scioscia says Josh Hamilton should apologize to Angels owner Arte Moreno
Jul 3, 2015, 10:01 AM EDT
"We'll leave it at that."
Yovani Gallardo extended his scoreless innings streak to 29 and a third
Jul 3, 2015, 9:11 AM EDT
He has a 2.56 ERA and a 72/31 K/BB ratio over 102 innings on the season.
The Braves get a walkoff win against Max Scherzer
Jul 3, 2015, 8:30 AM EDT
He wasn't hit hard, but the Braves hit 'em where they weren't.
Settling the Scores: Thursday's results
Jul 3, 2015, 6:38 AM EDT
Scott Kazmir dominated the Mariners last night.
Dodgers designate Brandon League for assignment
Jul 2, 2015, 11:28 PM EDT
League hasn't pitched in the majors this season due to a shoulder injury.
Reds GM Walt Jocketty says he's not trading Todd Frazier
Jul 2, 2015, 10:39 PM EDT
The Reds are expected to be sellers, but GM Walt Jocketty said Thursday that third baseman Todd Frazier isn't going anywhere.
Matt Boyd pulled from start after failing to record an out against the Red Sox
Jul 2, 2015, 9:23 PM EDT
After pitching into the seventh inning in his major league debut against the Rangers last Saturday, Blue Jays left-hander Matt Boyd failed to record an out in his start tonight against the Red Sox.
Freddie Freeman won't return from wrist injury before All-Star break
Jul 2, 2015, 8:26 PM EDT
Freeman hopes to return right after the All-Star break, but he acknowledges that it's a "best-case scenario."
Archie Bradley has no structural damage in shoulder
Jul 2, 2015, 7:28 PM EDT
Bradley has been out for a month with right shoulder tendinitis.
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Essence in Practice – a Revolution in Software Engineering?
March 26, 2015 in News
March 26, 2015 in News
December 15, 2014 in News
During the last weeks, several case studies on using ESSENCE got published:
1. One of the worlds largest reinsurers, Munich Re, has applied the Essence kernel with great results: http://www.omg.org/news/whitepapers/Munich_Re_Essence_Case_Study-2014-12-01_JP.pdf.
2. Worldwide agile at scale adoption with 1200 people achieved within nine months based on the Essence standard. http://www.ivarjacobson.com/uploadedFiles/Pages/Knowledge_Centre/Resources/Case_Studies/Resources/AsianTelecomm1.pdf. This case study involved developing a large number of practices around the Essence kernel, practices for scaling agile.
3. Development Team at Global Internet Services Company Learns and Applies Essence. Team very engaged and interactive: http://www.ivarjacobson.com/uploadedFiles/Pages/Knowledge_Centre/Resources/Case_Studies/Resources/Essence_globaltech1..pdf.
December 4, 2014 in News
One of the first and most prominent outputs from the SEMAT community is Essence – a standard that defines the smallest set of concepts that are common to all software projects, aiming to help teams assess the health of their software endeavor and to improve their way of working. Ivar Jabcobson introduced this work at a tech talk at Google Switzerland in July 2014.
In order to explore Essence in a practical setting, a 2-day workshop was hosted at Google Switzerland on Oct 22 by Martin Landers, an engineering manager for YouTube. He and his team of five engineers took a look at Essence and its "serious games". Martin Landers felt that "Playing progress poker, reviewing health indicators and defining checkpoints triggered some good conversations in the team and helped crystallize some risks that I thought the team wasn't aware of or vice-versa."
December 2, 2014 in News
A new paper by Ivar Jacobson, Barry Myburgh, Pontus Johnson, Paul McMahon and June Park has been published: SEMAT-Yesterday, Today and Tomorrow.
November 28, 2014 in News
July 31, 2014 in News
A presentation on ESSENCE given by Ivar Jacobson and Ian Spence at Google in Zurich is now available as Google Tech Talk at http://www.youtube.com/watch?v=WNlERrVxYjs&list=UUtXKDgv1AVoG88PLl8nGXmw. The talk has three parts: 1) Welcome to the State Club (by Ivar Jacobson), 2) Welcome to the world of Practices (by Ian Spence), 3) Q&A.
The presentation slides are also availabe from IJI at http://www.ivarjacobson.com/uploadedFiles/Pages/Knowledge_Centre/Resources/Presentations/Resources/SEMAT presentation at Google.pdf
July 31, 2014 in News
Thanks to the great work of the Latin American Chapter of SEMAT, the ESSENCE book is now available in Spanish. The Argentinian publisher Nueva Libreria is announcing the release of the book to book stores, distributors, and institutions.
Next August, the book will be distributed to the attendants to the Latin American Software Engineering Symposium LASES 2014. Ivar Jacobson will make the announce in his virtual conference during the event, and Paul McMahon will be signing books as a part of the activities of the event.
June 20, 2014 in News
On June 16, 2014 the Object Management Group (OMG) announced that its Board of Directors adopted "Essence Kernel and Language for Software Engineering Methods" as an official OMG standard.
"We're very excited that Essence has been adopted as an official OMG standard," said Dr. Richard Soley, Chairman and CEO of OMG. "By providing a common set of core concepts and language, Essence allows practitioners to flexibly construct and adapt software engineering methods. A very large 'thank you' to our members in the Essence 1.0 Finalization Task Force for getting it through the OMG technology adoption process."
June 16, 2014 in News
In April the Initial Essence Training Certification Process was completed and approved by every member of the executive committee of SEMAT consisting of June Park, Paul McMahon, Mira Kajko-Mattsson, Ian Spence, Arne Berre, Shihong Huang, and Michael Goedicke. The work on this process was led by Paul McMahon who is vice president of SEMAT Inc. The process was adopted in late April, and IJI has, as expected, applied and has been approved as an authorized training and certification institute.
Refer to the Initial Training Certification Process for more information on how to apply to become an authorized Essence Training and Certification institute.
June 4, 2014 in News
InfoQ has interviewed Ian Spence and Ivar Jabobson based on the CACM paper "Agile and SEMAT-Perfect Partners": http://www.infoq.com/articles/semat-agile-adoption


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On any trip to Berlin it is alway's nice to escape the hussle & bussle of city life and jump the ubahn down to this lovely area,more of a little village that an out lying...
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3 Days in Berlin
Romantic Guide to Berlin
Real Berlin away from tourist traps
On any trip to Berlin it is alway's nice to escape the hussle & bussle of city life and jump the ubahn down to this lovely area,more of a little village that an out lying district of this wonderful city.
There is so much to see,you have wonderful old historically important building's here such as the CITADEL,GOTHIC HOUSE,RATHAUS,PROTESTANT CHURCH OF...
After three days of enjoyable but tiring sightseeing in central Berlin, spandau was an opportunity to relax a bit more. The Citadel is well worth a visit.
It is a very nice place for wandering around and seeing the old buildings and Rathaus. Also it is convenient for shopping.
A really nice town to wonder around. All very pretty. I particularly recommend the cafe called the "Aldstadt cafe" which was right next to the big church. Lovely lady serving, polite and helpful. Really nice tasty, butter fresh scrambled eggs.
I dont know if I can call Spandau a village, a small town or a suburb of Berlin. Although it is part of Berlin, it has an air of a small town which I really liked. It is very picturesque and it is worth a visit. If the weather is not bad one can walk by the riiver, admire the...
The Rathaus and the Altstadt were very beautiful. The whole area had a small village feel and the locals were very friendly.
Went to Spandau on a Sunday and there was a wine festival taking place which was worth a visit. Stopping for coffee/tea with lovely cakes was very reasonable (€3 for 2 teas and cakes)
Didn't feel very welcome though in the altstadt as a visitor.
Other areas of Berlin are better.
Have been here a number of times now if you ever want a base in Berlin with fast travel links to everywhere in Berlin then this is the place with u bahn s bahn and overground rail links to schonefeld airport and numerous bus links but when you come back at night it feels like you are coming home whichever...
very extensive Market, lovely and varied selection of merchandise. A couple of nice welcoming pubs too.
What has Spandau ever done to deserve being twinned with Luton???
Historic Spandau is best thought of as a quaint village dropped into urban Berlin. You can easily imagine being far out in the countryside while you tour Spandau. The central plaza has a Farmers Market on certain days and many fine shops. Real people live there and shop there, so prices are reasonable and quality is high. There is a...
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In the Kitchen with Kroger
- Great Grilled Burger
- Barbecued Pulled Pork
- Bourbon Pecan Turtles with Fleur de Sel
- Grilled Panzanella
- Crab Au Gratin
- Red Velvet Pancakes with Maple Cream Cheese Topping
- Braised Beef Shanks and White Beans
- Herbed Biscuit Spiral Ham Sandwiches
- New Orleans Barbecue Shrimp Dip
- Baked Cod with Herb-Roasted New Potatoes
- Dark Chocolate Truffles
- Asian "Salisbury" Steak
- Pizza Burger Appetizer
- Sweet Corn & Crab Bisque
- Shrimp & Vegetable Spring Rolls
- Mac & Cheese Muffins
- Sweet Potato Casserole
- Pumpkin Custard
- Popcorn Balls
- Chipotle Lime Breaded Chicken Strips
- Lobster Risotto
- Salmon Filets With Ginger Sauce
- White Bean Cashew Chicken Chili
- Blackened Mahi Mahi
- Braised Pork And Sauerkraut Balls
- Grilled Pear Chicken
- Cuban Sandwich
- Clambake
- Strawberry Scones
- Bacon Chive Burger
- Grilled Chicken Breast Sandwich
- Grilled Swordfish Kabobs
- Grilled Ribeye Steak and Caesar Salad
- Chipotle-plum BBQ baby back pork ribs
- Grilled Hot Italian Sausages
- Sponge Cake with fresh berries, lemon curd and mascarpone
- Fritatta With Asparagus
- Kentucky Burgoo
- Guacamole with Pico de Gallo
- Grilled Lamb Chops
- Salmon Cakes
- Fettuccine with Shrimp, Scallops and Lobster Cream Sauce
- Hanky Panky
- Chipped Beef Cheeseball
- Shepherds Pie
- Beer Battered Cod
- Beignets
- Beans Greens with Corn Bread
- Ribeye With Shrimp Scampi
- Blueberry Mascarpone Stuffed Strawberries
Sauteed Chicken Provencal
Updated: Wednesday, February 5 2014, 03:40 PM EST
Servings: 4
4-Boneless Skinless Chicken cleaned and trimmed butterflied and cut in 1/2
4-Tomatoes, diced
1 small jar -Olives, sliced
½ lb. -Mushrooms, Cleaned and Sliced
2 medium-Onions, Small dice
3 TBSP-Garlic, Fine Chop
1 bunch-Green Onion, Sliced
1 jar-Capers, Drained and Rinsed
8 TBSP-Olive Oil, 3-4 Tbsp for sautéing and 3-4 Tbsp for sauce
1 stick-Butter, cut into small cubes
Salt and Pepper to taste to season chicken
Salt and Pepper to taste for the sauce
Season your cleaned and trimmed Chicken Breasts with salt and pepper. Heat a sauté pan and add Enough Olive Oil to Sautee the chicken. After the Chicken is fully cooked set aside on serving dish to rest. Into already hot chicken pan add in remaining Olive Oil and bring to temp. To the oil add in the onions and mushrooms. Sauté this until tender and onions are translucent. To this add in the garlic olives and capers. Sautee this until up to temperature. Finish off by adding in the tomatoes and green onions tossing a few times to bring up to an even temperature, finishing with a few cubes of butter. Tossing this to incorporate into a delicious sauce and season with salt and pepper. Pour this over your platter of Chicken and serve. This is great with other garden vegetables or roasted potatoes. Is even great with rice or pasta. This is a sauce that can be changed with whatever is fresh from your Kroger or garden. Fennel eggplant spinach or summer squash would be great changes to this dish. The garden is your leader on this dish.
Related Stories
In the Kitchen with Kroger Updates and Events
Meet the Kroger Chefs!Chef Sean Schmidt
Chef Sean Schmidt was born in Chicago, IL and grew up there until his family relocated to Oldbridge, New Jersey. After 6 years, Sean returned to the Chicago area and attended Plainfield High School. He was then accepted to and graduated from Johnson & Wales University with a Bachelor's Degree in Culinary Arts.
Sean joined Kroger in 2000 and has served in many capacities in various locations including Chef's Choice Catering, Anderson Towne Center Kroger Store, and the Lebanon and Middletown Marketplace Stores. Sean's favorite dishes to prepare are grilled items - meats, vegetables and even desserts. Sean is an Executive Chef at the Centerville Marketplace Store.
Sean likes to garden and spend time with his wife and kids. Chef Christopher J. Alexander
Chef Christopher J. Alexander was born in Lubbock, Texas but raised in Xenia, Ohio. He graduated from Xenia High School then attended Sinclair Community College and the New England Culinary Institute.
After working in various 4 star restaurants in locations including New Orleans, Vermont, and The British Virgin Islands, Christopher joined Kroger in 2009 and has served at both the Stroop Road Fresh Fare and Englewood Marketplace. Christopher has been a fan of the culinary arts since elementary school when he would spend time cooking with his grandfather. He loves to cook all foods, Asian, Latina American, Southern and Southwestern American. Christopher says "I am a well versed rounds chef. I can do tradition Bakery baking as well as High end Pastries. I really enjoy butchery and meat fabrication ( primals to sausage). But really find myself at home in an eclectic Euro/American line."


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Hey Fellow Apple Users,
As the title of my discussion suggests, yes my iPhone5 charger has stopped functioning properly in fact it's stopped working altogether! I tried different ways to solve the problem ie different sockets to charge the iPhone 5, changing the adapter, plugging the cable into my laptop. To all of which were no success. I would like some tips on how to handle this query!
Many Thanks and looking forward to hearing from you all soon.
Make Genius reservation and take iPhone, charger, and Lightning USB cable to Apple for resolution under Warranty. All these items are covered by the one year Warranty.
Retrieving data ...


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You can make an online donation by clicking the Donate button.
Sensory Week was so much fun!
Music by: Imagine Dragon - "On Top of the World" VEVO
"Talent Week" was a great way to start!
Check back for more videos!
Below is the professional staff at this year's Summer Camp.
Want to help?
Check out the Camp Wish List or Contact Us for ways you can personally or corporately invest in a great summer!
Dear Friends and family of EMDC,
We are making great strides in being able to provide more services for individuals with special needs
in the community. We will be unveiling new programming in the very near future! We are so
excited! But, before we can do that, we need your help.
We have been asked to compile a list of individuals that would consider using Empower Me as a
permanent residence for their child once he or she turns the age of 21. The level of care for a
residential model has not yet been determined, and we know this can cover a broad spectrum of needs.
As a preliminary step, however, we are trying to gauge interest in supported, community living for
young adults with special needs.
If we had the facilities and appropriate level of care, would you be interested in having your child live
in those facilities full-time. I know what you are thinking....What? When? How? What would it cost?
Those are all great questions, and are all being discussed at this time. What we need is your child's
name and current age if you do not have other arrangements already made for when they become a
dults. There is no commitment, you are not signing on a dotted line. We just need to prove that there
is a need for this type of housing in this area.
We are asking you to email firstname.lastname@example.com with the name and age, and we will
compile that list.
Please feel free to forward this to anyone and everyone that you think would benefit from the
housing. We will give more information once we have the details worked out to
share. Your child does not have to be 21 years of age for you to put their name on this list. If you are
able to see this as a possibility, 5, 10, 15 years down the road, please consider giving us the
information so we can best plan to meet as many individuals' needs as possible in the future.
Thank you so much for your help!
We are still Daring to DREAM!
Saturday, June 6th 7:30 am
James Ward Agricultural Center Lebanon, TN
Jere's Ride is a great way to support Empower Me Day Camp, get some exercise, have family fun, and celebrate the life of Jere McCulloch. Register for the different rides, find out how you can volunteer, and read all about last year's ride. www.jeresride.com
To donate in Memory or Honor of a loved one, click the GREEN Memorial button.
We are a 501c3 non-profit organization-EIN:62-1785371 and a public charity recognized by the IRS.gov website. Note: We use a safe and secure PayPal connection.
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Thanks for the Memories!
Summer Camp 2014
Themed Weeks!
Click on our You Tube videos
to see each week in pictures
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Sensory (June 16-20)
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The Social Science Working Group (SSWG) recently held elections for five board seats: representatives of psychology, geography, and anthropology; and two at-large positions.
SCB News Blog
The SCB News Blog is the best source for member-oriented news from the Society for Conservation Biology. Here you'll find an account of what's new at SCB, coverage of SCB members in the news, and conservation-related commentary and reportage.
Come often and be informed of the goings-on in this global community of conservation professionals dedicated to advancing the science and practice of conserving Earth's biological diversity.
Have a story you'd like to share in the SCB News blog? E-mail us your idea.
SCB Welcomes New Section Leaders
Following a busy election season, SCB is pleased to welcome new leaders to four Sections plus the Freshwater Working Group.
IPBES Closes: Cheering with a Pinch of Salt
It's a busy final day at IPBES-2 as the Plenary closes with an approved work program and budget.
IPBES: Red Lines Becoming Green
The past few days have been surprising as it became apparent that the position of stakeholders in the IPBES process was not at all sure or guaranteed from the wishes and perspectives of Member States.
IPBES Day 3
The message from yesterday is basically the same; it is uphill with very little substantial progress. Whenever the term "stakeholder" shows up, it is put in square brackets (for those of you unfamiliar with the process it means that it is something that is not agreed upon and that needs to be resolved later).


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≡ Category: Audio Books, Literature | ≅ 5 Comments
This is surely worth a quick mention: Today we added to our list of Free Audio Books a recording of Raymond Carver reading his most famous story, "What We Talk About When We Talk About Love.[...]
≡ Category: Audio Books, e-books | ≅ 1 Comment
Edgar Allan Poe was born on this day 206 years ago. BoingBoing suggests celebrating Poe's birthday with these Vincent Price wines. But seeing that the 2012 Raven Cabernet Sauvignon runs $75.00, we're going to steer you toward something free.[...]
≡ Category: Audio Books, Literature | ≅ 6 Comments
Hemingway and Faulkner, Faulkner and Hemingway…. The American literary canon has expanded so much in the past thirty years or so that it almost spans the globe, like American business, drawing in writers from every possible corner.[...]
≡ Category: Audio Books, Literature, Sci Fi | ≅ Leave a Comment
Neil Gaiman sent Ray Bradbury a gift for what turned out to be his last birthday, his 91st. It was a story called "The Man Who Forgot Ray Bradbury." And when Bradbury's editor read it to the bed-ridden author, he reportedly took great pleasure in it.
What could have been better? I guess only hearing Neil Gaiman read the story himself.
≡ Category: Audio Books, Literature | ≅ 1 Comment
"The Dead" is the last – and most memorable – short story in James Joyce's first book, Dubliners. Set during a New Year's feast in 1904, the story focuses on Gabriel Conroy, a plump, bespectacled young man who is painfully aware of his own social ineptitude.[...]
≡ Category: Audio Books, e-books, Film, iPad, Online Courses | ≅ 21 Comments
Santa left a new Kindle, iPad, Kindle Fire or other media player under your tree. He did his job. Now we'll do ours. We'll tell you how to fill those devices with free intelligent media — great books, movies, courses, and all of the rest. And if you didn't get a new gadget, fear not.[...]
≡ Category: Audio Books, Books, History, Literature | ≅ 1 Comment
Image by New York Public Library
Last Christmas, we featured Charles Dickens' hand-edited copy of his beloved 1843 novella A Christmas Carol. He did that hand editing for the purposes of giving public readings, a practice that, in his time, "was considered a desecration of one's art and a lowering of one's dignity.
≡ Category: Audio Books, Literature | ≅ 2 Comments
jQuery(document).ready(function($) {
≡ Category: Audio Books, Literature | ≅ 2 Comments
A quick heads up for Thomas Pynchon fans. Four decades after its publication, you can finally get Gravity's Rainbow as an audio book — possibly even as a free audio book.[...]
≡ Category: Audio Books, Comedy | ≅ Leave a Comment
The sequel to Adam Mansbach's best-selling mock children's book, Go the F**k to Sleep is out. Say hello to You Have to F**king Eat.
As mentioned last week, you can download a free audio version read by Breaking Bad star Bryan Cranston over at Audible.com through December 12th.


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O Say Can You See: The Greatest Patriotic Super Heroes of All-Time
Comic Books
Showing results 1-3 of 3
"Avengers: Age of Ultron" Thor, "A New Hope" Darth Vader, Retro Wolverine and much more in this week's installment.
While the weather is cooling down outside, the action is heating up on gaming platforms with popular franchises releasing new adventures, including "Fable III," "Catlevania: Lords of Shadow," "Medal of Honor" and more.
Day 3 of E3 2009 is in the books, and we've compiled some of the interesting news of the day, including some "Final Fantasy XIV" info, another Kojima announcement, and a promotion for Lionhead's Peter Molyneux.
Archives: All | Comic Books | TV/Film | Video Games | Web Comics


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Williams has high hopesPublished 8:53pm Saturday, September 10, 2011
By Robert Hudson
The Selma Times-Journal
Football season is in full swing, but the season is also underway on the Concordia College campus for a different kind of football.
The Concordia College Hornets men's soccer team began its season Monday with a 2-1 loss on the road against South Georgia.
The Hornets began the season under the tutelage of new head coach Gregory Williams, who has high hopes for the program.
"My aim is to just get into the playoffs," Williams said. "Then, we'll take it from there."
Williams, who served as an assistant coach on the team for four years, has 18 freshman on his team this year.
Williams said it's going to take a lot of work in order for the Hornets to achieve their goal of making it to the postseason.
"Just like everything else, it's going to take hard work," Williams said. "We have to want it, and if the players want it, most likely we'll achieve it."
Williams said he's excited to be in charge of the soccer program.
"It's an honor to be head coach at this school," Williams said. "I hope to take them to bigger and better things."
Working with a young team, Williams believes conditioning will play a huge part in how successful the Hornets are.
"The main thing we need to work on is fitness," Williams said. "We started a little late and we have some new freshman that have to get acclimatized. Fitness is the key to our success."
Williams said his team is made up of young, raw talent, and getting them to play as a team will be another factor in how successful the Hornets are this season.
"They're young kids," Williams said.
"Some of them are 18 and just came out of high school. We've never had that before. It's going to be a new experience for a lot of them and I hope they're up for the challenge."
The Hornets will take the field again Sunday for their home opener at Bloch Park against Oakwood University at 3 p.m.
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Machined from stock to exacting tolerances, eliminates need for time-consuming reaming. Smooth internal finish lets plunger detents function reliably. Parallel sides and extra length staking studs enhance fit so tube won't shoot loose.
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Signalink USB and Yaesu FT-857D
This webpage describe how to set up the Signalink USB interface and Yaesu FT-857D for digital operations by NA4IT
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About Signalink USB and Yaesu FT-857DThis resource is listed in dxzone.com under 2 categories. Its main category is Sound Card Interfacing (Sound Card to radio interfaces). "Signalink USB and Yaesu FT-857D" is listed in our web site index since Saturday Sep 8 2012 and till now received a total of 1285 hits.
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Startup News – sorted by country
Recent JobsIntern for Sales & Business Development at StyleLounge - Hamburg, Germany
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Tag Archives: Podio
Citrix acquires Copenhagen based collaboration platform Podio
Citrix today announced it has acquired the Danish startup Podio for an undisclosed sum. Podio, which is based in Copenhagen, was founded in 2009 and offers a collaborative work platform which supports people and teams getting work done the way they … Continue reading
Posted in Denmark-Startups Tagged Acquisition, Citrix, collaborative work, Copenhagen, Podio Comments Off