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subset: commoncrawl


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Lawrence Joynes charged with child abuse, sex abuse of a minor, rape
Lawrence Joynes, a longtime music teacher in Montgomery County, sexually abused at least 14 students at a Silver Spring school since 2005, Montgomery County Police say.Comment
Amber Stanley murder: Police canvas Kettering neighborhood
Homicide detectives went door-to-door Monday in the Kettering community handing out flyers about the Aug. 22, 2012 slaying of 17-year-old Amber Stanley. The honor student was shot dead in her bedroom.Comment
Thousands lose homes in Md. in new foreclosure wave
A second round of the housing crisis is striking Maryland as a backlog of delinquent loans move to foreclosure. Between January and June, Maryland saw the third highest rate of foreclosures in the nation after having one of the lowest foreclosure rates.Comment
Maryland kicks off tax-free holiday
Starting Sunday, shoppers in Maryland can get a break on the state's 6 percent sales tax on clothing and shoes priced under $100.
Laurel delivery driver assaulted, robbed
Police say a delivery driver was robbed by several men outside an apartment building in Laurel late Saturday.Comment
Brig. Gen. Linda Singh to command Md. Army National Guard, breaking two barriers
The Maryland Army National Guard is getting a new commander, Brig. Gen. Linda Singh, who will be the first female and the first African American in the post.Comment
Lanham fire displaces two adults, three cats
Two adults and three cats have been displaced after an early morning house fire in Prince George's County.Comment
Police investigate stabbings in Laurel, Odenton
Police are investigating two overnight stabbings in Laurel and Odenton. Two victims were left with non-life threatening injuries.
Local group loses out on Las Vegas vacation and $25,000
An Oxon Hill woman planned a trip for 28 of her family and friends. But she has to tell them their money is gone and the vacation is off even though she spent more than $25,000.Comment
Maryland football 2013: Randy Edsall's 3rd year is last in ACC
Although Maryland hasn't won an ACC title since 2001 and hasn't had a winning record in the league over the past six years, that hasn't frayed the confidence of coach Randy Edsall or his players.Comment
Terry Verdier killed in mowing accident near Hagerstown
Maryland State Police say 42-year-old Terry Verdier has died in a mowing accident after a tractor rolled over on top of him at a home near Smithsburg.Comment
Teen in critical condition after Annapolis crash; two others injured
Police say two vehicles were likely speeding early Sunday morning when they ran off the roadway near a curve and struck trees. A 17-year-old boy who was one of the drivers was in critical condition Sunday morning.Comment
Jacob Colin Hess pleads guilty to arson; can attend college, play football
An 18-year-old man has pleaded guilty to his role in a series of western Maryland arsons but will be permitted to attend college this fall at Bethany College in West Virginia, where he has a Merit Scholarship and was recruited to play football.Comment
Immigration campaign passes by some in GOP
Immigration advocates are spending August trying to generate momentum in favor of remaking immigration laws in Congress.Comment
Moneta Jo Strickland found dead in park
Officials in St. Mary's County say Moneta Jo Strickland, who went missing Thursday, has been found dead. She was engaged to be married next March.Comment
Yellow Ribbon Fund offers resources to returning soldiers, military families
The Yellow Ribbon Fund hosted an event Saturday to help soldiers cope with returning home from deployment. It also introduced resources available to military families.Comment
Travon Millar charged with attempted murder
Police say Travon Millar ran over another man with his car after the two argued over the return of a stolen cellphone Friday.Comment
William Payton Bell: Waldorf shooting leads to barricade during warrant execution
A Charles County man suspected of mail fraud was shot Friday morning after he opened fire on law enforcement officers who came to serve a warrant for his arrest.Comment
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Photo Galleries Pictures from around the region
Daily Eye Wonder January 2015
The L'Enfant Plaza Metro station evacuation in pictures
Photos: D.C.'s first accumulating snow of the season
Photos: Plane crashes into homes in Gaithersburg, Md.
PHOTOS: Marion Barry was D.C.'s 'Mayor for Life'
Photos: Marion Barry Funeral Procession around D.C.


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At 10:30 a.m. on Sept. 24, 1960, Mrs. William B. Franke, wife of the Secretary of the Navy, smashed a bottle of champagne across the bow of the USS Enterprise as the rushing seawater freed it from its last keel block.
Yard president William E. Blewett Jr. paid tribute to the thousands of workers who "labored with imagination, skill and pride to build a vessel worthy of its name."
Today, the Enterprise sits across the harbor at Naval Station Norfolk, preparing for two final, six-month deployments before it's decommissioned in 2012.
Neither the Navy nor the ship's crew has planned an event to celebrate the milestone, preferring to wait until Nov. 25, 2011, the 50th anniversary of the Enterprise becoming an official member of the fleet.
Nonetheless, when the one-of-a-kind supercarrier was launched that Saturday five decades ago, it cemented Newport News Shipbuilding and Dry Dock Co. as the premier shipyard in the United States and positioned it as an indispensable asset even today.
"The Enterprise was seen not simply as the first of a new class of carriers, but a step in the transformation of the entire fleet," said James C. Bradford, a Navy historian and professor at Texas A&M University.
To build the ship, the yard had to alter its facilities and dry dock to be able to accommodate the largest vessel ever constructed. Further, it had to train and retain a cadre of highly experienced and skilled workers to undertake the most complex shipbuilding project ever attempted.
"The Enterprise got (Newport News) the facility and the trained workforce. There was simply no other yard capable of doing this kind of work," Bradford said. "Building the Enterprise really solidified Newport News Shipbuilding."
Since the launch of the Enterprise, all 12 of the U.S. Navy's aircraft carriers have been built in Newport News, bringing billions of dollars of contracts and decades worth of work for tens of thousands in Hampton Roads.
It remains the only yard capable of building and refueling the nation's fleet of aircraft carriers, a monopoly that's provided the yard with a steady and lucrative stream of business, a line of work that will likely continue for decades to come.
"The success of the USS Enterprise led to the development of the … Nimitz class carriers, 10 of which are presently in service, providing an all-nuclear carrier force for the U.S. Navy," said Tom Dougan, a spokesman for the Navy's nuclear reactors division.
After completing the 10th and final ship of the Nimitz class, the George H.W. Bush, in 2009, Newport News began building the first ship in a new class of carriers, the Gerald R. Ford.
With a scheduled 2015 commissioning, the Ford would likely be back in Newport News around 2040 for its mid-life overhaul.
It's all work for which the Big E paved the way.
The yard had built 17 carriers before the Enterprise, including ships in the Forrestal class and the Kitty Hawk class, but it wasn't the only player in the business. The New York Naval Shipyard and New York Shipbuilding Co. each were building flattops at the time.
But the Enterprise was a different animal. Outfitted with eight nuclear reactors that would give it virtually unlimited range and a horsepower of 200,000, it was a marvel of modern engineering.
The Navy needed the nation's best and brightest to design the experimental ship, which required 915 designers and more than 16,000 construction drawings — each done by hand with mechanical pencils and based on calculations done with sliderules.


text:
: FireRed hack:
Pokemon Apollo
View Single Post
May 12th, 2013 (03:21 AM).
Formerly known as 11bayerf1
Join Date: Dec 2008
Location: Hong Kong
Age: 20
Gender: Male
Posts: 537
Quote originally posted by
What is the original rom to patch this on?
View original post
Fire Red! I believe its somewhere on the first post. I'll make it more clear.
Well, I'm no real expert on this kind of stuff anyways. Just saying what I wanted to.
It's certainly possible, I plan on doing that definitely. I'll look into it more. I forget whether the Team Steam sprite change is reset after warping though.
LP's sprite change only applies to the OW, though.
And, at least it's still more work.
Yeah but LP is on a ruby rom. Using the Fire Red Hacked engine, it's possible to change the front, back and OW sprites after setting certain variables.
MrDollSteak's Decap. and Attack Rombase (Version 1.5a)
Gen VI: DS-Style 64x64 Pokemon Sprite Resource
Sugimori Palettes: DS-style 64x64 Pokémon Sprite Resource
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Previous Episode | Next Episode
A Thousand And One FrightsA Thousand And One Frights (1962) - Lippy the Lion and Hardy Har Har Cartoon Episode Guide by Dave Koch
This page has been viewed 13 times this month, and 609 times total.
- Hanna-Barbera Studios
- Lippy the Lion and Hardy Har Har Episode Guide Pictures
- Featuring: Lippy the Lion, Hardy Har Har, Abenzikh, Ruby, Shiek.
- First Aired on November 12, 1962.
- Originally Released in Syndication.
- Running Time: 5 minutes.
- Color
A Thousand And One Frights Cartoon Pictures:
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Cartoon Summary:
Lippy and Hardy come across a arabian who's going to commit sucide because he lost his ruby. Lippy and Hardy find out the ruby is his girlfriend.
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Do you love A Thousand And One Frights, or do you think it is the worst cartoon ever? Let us know what you think! Surely you have an opinion... so share what you think. Take a minute and post your own comments about this cartoon here.


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Created to channel the spirit of Saturday seven days a week, this collection from Kate Spade Saturday includes a plethora of accessories designed to get you through it all. Adjustable and adorable, the two-tone leather Easy Everyday Belt is meant to be worn…well, everyday. Pair it with seersucker shorts and a crisp white button-up to achieve that perfectly laid-back look.
Contrast leather trim. Adjustable hidden enamel buckle.
Please see size chart for detailed measurements.
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Covenantal Conduct
The Outcome of Performing Israel's Faith
Law without theology conveyed in lore—exegesis, narrative, topical exposition—yields legalism. It does not fully express Israel's partnership with God, omitting as it does the theological convictions that animate action. Stated simply: Halakhah without Aggadah—rules without convictions—produces robots, automatons of the law. Theology without law conveyed in rules of normative conduct—Aggadah without Halakhah, beliefs without corresponding behavior—yields not a covenanted community but a radically isolated individual. Theology without social norms does not embody that same partnership, omitting as it does the essential aspect of realizing the covenant in actualities of the workaday world. Covenantal conduct contains imperatives of attitude and belief ("You will love the Lord your God with all your heart, soul, and might") and action and behavior ("Love your neighbor as yourself").
We have examined massive testimonies in support of E. P. Sanders's view of covenantal nomism. He argues against the idea of Judaism as "a petty legalism, according to which one had to earn the mercy of God by minute observance of irrelevant ordinances." The relationships between the narrative and theology of idolaters and Israel and between the narrative and theology of repentance and atonement have shown the relevance of ordinances in responding to the grace of God set forth in the Torah. The narrative accounts for the idolaters and their standing and task in world history, the law translates the matter into everyday performance of the faith. The narrative of sin and repentance, atonement and forgiveness, defines the context for the text of the Temple rite, faithfully preserved in synagogue liturgy for the Day of


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WESTCHESTER COUNTY, N.Y. – Metro-North reported short delays on its lines Harlem and Hudson lines Friday morning, less than 12 hours after the trains came to a grinding halt. Traffic has been slowed in Northern Westchester as a result of several incidents.
Delays were about 10 minutes on the Hudson and Harlem lines, according to the Metro-North website. Service was restored late Thursday night, more than three hours after a computer problem shut down all Metro-North. Trains were running close to schedule on Friday morning except on the Danbury, Conn., line, where commuters had to take a bus to the South Norwalk branch.
An accident on the southbound Taconic State Parkway at Baldwin Road in Yorktown was reported toward the end of the morning commute.
Earlier, an accident on Route 100 North at Goldens Bridge Road around 6:40 a.m. also slowed traffic.
A disabled vehicle had blocked traffic on southbound Route 9A South near Hawkes Road earlier in the morning commute before being cleared.
Another disabled vehicle, on the southbound Taconic State Parkway between FDR State Park and Route 134, reported at 8 a.m., is also causing delays.
A disabled bus blocked one lane on the southbound New York State Thruway between Route 9W and the Tappan Zee Bridge span in an incident reported at 6 a.m.
- 1 Former Exec From PepsiCo In Purchase Resigns From Toyota After Drug Bust
- 2 New Scam Showing Up On Facebook Could Cost You Lots Of Money
- 3 Teenager Identified In Fatal Sprain Brook Crash
- 4 July 4 Terror Warning Security Measures In Westchester Detailed
- 5 Passengers Stranded For Hours Overnight On Metro-North's New Haven Line


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Are you Elisabeth Mangold?Claim your profile
Publications (106)605.47 Total impact
Article: A post GWAS association study of SNPs associated with cleft lip with or without cleft palate in submucous cleft palateAmerican Journal of Medical Genetics Part A 03/2015; 167(3):670-3. DOI:10.1002/ajmg.a.36891 · 2.05 Impact Factor
Article: Genome-wide Association Study and Meta-Analysis Identify ISL1 as Genome-wide Significant Susceptibility Gene for Bladder Exstrophy[Show abstract] [Hide abstract]
ABSTRACT: The bladder exstrophy-epispadias complex (BEEC) represents the severe end of the uro-rectal malformation spectrum, and is thought to result from aberrant embryonic morphogenesis of the cloacal membrane and the urorectal septum. The most common form of BEEC is isolated classic bladder exstrophy (CBE). To identify susceptibility loci for CBE, we performed a genome-wide association study (GWAS) of 110 CBE patients and 1,177 controls of European origin. Here, an association was found with a region of approximately 220kb on chromosome 5q11.1. This region harbors the ISL1 (ISL LIM homeobox 1) gene. Multiple markers in this region showed evidence for association with CBE, including 84 markers with genome-wide significance. We then performed a meta-analysis using data from a previous GWAS by our group of 98 CBE patients and 526 controls of European origin. This meta-analysis also implicated the 5q11.1 locus in CBE risk. A total of 138 markers at this locus reached genome-wide significance in the meta-analysis, and the most significant marker (rs9291768) achieved a P value of 2.13 × 10-12. No other locus in the meta-analysis achieved genome-wide significance. We then performed murine expression analyses to follow up this finding. Here, Isl1 expression was detected in the genital region within the critical time frame for human CBE development. Genital regions with Isl1 expression included the peri-cloacal mesenchyme and the urorectal septum. The present study identified the first genome-wide significant locus for CBE at chromosomal region 5q11.1, and provides strong evidence for the hypothesis that ISL1 is the responsible candidate gene in this region.PLoS Genetics 03/2015; 11(3):e1005024. DOI:10.1371/journal.pgen.1005024 · 8.17 Impact Factor
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ABSTRACT: Genome integrity is continuously challenged by the DNA damage that arises during normal cell metabolism. Biallelic mutations in the genes encoding the genome surveillance enzyme ribonuclease H2 (RNase H2) cause Aicardi-Goutières syndrome (AGS), a pediatric disorder that shares features with the autoimmune disease systemic lupus erythematosus (SLE). Here we determined that heterozygous parents of AGS patients exhibit an intermediate autoimmune phenotype and demonstrated a genetic association between rare RNASEH2 sequence variants and SLE. Evaluation of patient cells revealed that SLE- and AGS-associated mutations impair RNase H2 function and result in accumulation of ribonucleotides in genomic DNA. The ensuing chronic low level of DNA damage triggered a DNA damage response characterized by constitutive p53 phosphorylation and senescence. Patient fibroblasts exhibited constitutive upregulation of IFN-stimulated genes and an enhanced type I IFN response to the immunostimulatory nucleic acid polyinosinic:polycytidylic acid and UV light irradiation, linking RNase H2 deficiency to potentiation of innate immune signaling. Moreover, UV-induced cyclobutane pyrimidine dimer formation was markedly enhanced in ribonucleotide-containing DNA, providing a mechanism for photosensitivity in RNase H2-associated SLE. Collectively, our findings implicate RNase H2 in the pathogenesis of SLE and suggest a role of DNA damage-associated pathways in the initiation of autoimmunity.Journal of Clinical Investigation 12/2014; 125(1). DOI:10.1172/JCI78001 · 13.77 Impact Factor
Article: Compound Heterozygosity of Low-Frequency Promoter Deletions and Rare Loss-of-Function Mutations in TXNL4A Causes Burn-McKeown Syndrome[Show abstract] [Hide abstract]
ABSTRACT: Mutations in components of the major spliceosome have been described in disorders with craniofacial anomalies, e.g., Nager syndrome and mandibulofacial dysostosis type Guion-Almeida. The U5 spliceosomal complex of eight highly conserved proteins is critical for pre-mRNA splicing. We identified biallelic mutations in TXNL4A, a member of this complex, in individuals with Burn-McKeown syndrome (BMKS). This rare condition is characterized by bilateral choanal atresia, hearing loss, cleft lip and/or palate, and other craniofacial dysmorphisms. Mutations were found in 9 of 11 affected families. In 8 families, affected individuals carried a rare loss-of-function mutation (nonsense, frameshift, or microdeletion) on one allele and a low-frequency 34 bp deletion (allele frequency 0.76%) in the core promoter region on the other allele. In a single highly consanguineous family, formerly diagnosed as oculo-oto-facial dysplasia, the four affected individuals were homozygous for a 34 bp promoter deletion, which differed from the promoter deletion in the other families. Reporter gene and in vivo assays showed that the promoter deletions led to reduced expression of TXNL4A. Depletion of TXNL4A (Dib1) in yeast demonstrated reduced assembly of the tri-snRNP complex. Our results indicate that BMKS is an autosomal-recessive condition, which is frequently caused by compound heterozygosity of low-frequency promoter deletions in combination with very rare loss-of-function mutations. Copyright © 2014 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.The American Journal of Human Genetics 11/2014; 95(6). DOI:10.1016/j.ajhg.2014.10.014 · 10.99 Impact Factor
Article: Immunochip-Based Analysis: High-Density Genotyping of Immune-Related Loci Sheds Further Light on the Autoimmune Genetic Architecture of Alopecia AreataJournal of Investigative Dermatology 10/2014; 135(3). DOI:10.1038/jid.2014.459 · 6.37 Impact Factor
Article: Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder[Show abstract] [Hide abstract]
ABSTRACT: Bladder exstrophy-epispadias complex (BEEC), the severe end of the urorectal malformation spectrum, has a profound impact on continence as well as sexual and renal functions. It is widely accepted that for the majority of cases the genetic basis appears to be multifactorial. Here, we report the first study which utilizes genome-wide association methods to analyze a cohort comprising patients presenting the most common BEEC form, classic bladder exstrophy (CBE), to identify common variation associated with risk for isolated CBE. We employed dis- covery and follow-up samples comprising 218 cases/865 controls and 78 trios in total, all of European descent. Our discovery sample identified a marker near SALL1, showing genome-wide significant association with CBE. However, analyses performed on follow-up samples did not add further support to these findings. We were also able to identify an association with CBE across our study samples (discovery: P 5 8.88 3 1025; follow- up: P 5 0.0025; combined: 1.09 3 1026) in a highly conserved 32 kb intergenic region containing regulatory ele- ments between WNT3 and WNT9B. Subsequent analyses in mice revealed expression for both genes in the geni- tal region during stages relevant to the development of CBE in humans. Unfortunately, we were not able to replicate the suggestive signal for WNT3 and WNT9B in a sample that was enriched for non-CBE BEEC cases (P 5 0.51). Our suggestive findings support the hypothesis that larger samples are warranted to identify asso- ciation of common variation with CBE.Human Molecular Genetics 10/2014; 23(29). DOI:10.1093/hmg/ddu259 · 6.68 Impact Factor
Conference Paper: Extending the population spectrum for nonsyndromic orofacial clefting: Recruitment and genetic analyses in an Arabian population from Yemen36th Annual Meeting of the; 08/2014
Article: Orofaziale SpaltenZahnmedizin up2date 07/2014; 8(04):391-424. DOI:10.1055/s-0033-1357927
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ABSTRACT: Idiopathic achalasia is characterized by a failure of the lower esophageal sphincter to relax due to a loss of neurons in the myenteric plexus. This ultimately leads to massive dilatation and an irreversibly impaired megaesophagus. We performed a genetic association study in 1,068 achalasia cases and 4,242 controls and fine-mapped a strong MHC association signal by imputing classical HLA haplotypes and amino acid polymorphisms. An eight-residue insertion at position 227-234 in the cytoplasmic tail of HLA-DQ$beta$1 (encoded by HLA-DQB1*05:03 and HLA-DQB1*06:01) confers the strongest risk for achalasia (P = 1.73 × 10(-19)). In addition, two amino acid substitutions in the extracellular domain of HLA-DQ$alpha$1 at position 41 (lysine encoded by HLA-DQA1*01:03; P = 5.60 × 10(-10)) and of HLA-DQ$beta$1 at position 45 (glutamic acid encoded by HLA-DQB1*03:01 and HLA-DQB1*03:04; P = 1.20 × 10(-9)) independently confer achalasia risk. Our study implies that immune-mediated processes are involved in the pathophysiology of achalasia.Nature Genetics 07/2014; 46(8):901-904. DOI:10.1038/ng.3029 · 29.65 Impact Factor
Article: Nonsyndromic Cleft Lip with or without Cleft Palate: Increased Burden of Rare Variants within Gremlin-1, a Component of the Bone Morphogenetic Protein 4 Pathway[Show abstract] [Hide abstract]
ABSTRACT: Background The genes Gremlin-1 (GREM1) and Noggin (NOG) are components of the bone morphogenetic protein 4 pathway, which has been implicated in craniofacial development. Both genes map to recently identified susceptibility loci (chromosomal region 15q13, 17q22) for nonsyndromic cleft lip with or without cleft palate (nsCL/P). The aim of the present study was to determine whether rare variants in either gene are implicated in nsCL/P etiology.Methods The complete coding regions, untranslated regions, and splice sites of GREM1 and NOG were sequenced in 96 nsCL/P patients and 96 controls of Central European ethnicity. Three burden and four nonburden tests were performed. Statistically significant results were followed up in a second case-control sample (n = 96, respectively). For rare variants observed in cases, segregation analyses were performed.ResultsIn NOG, four rare sequence variants (minor allele frequency < 1%) were identified. Here, burden and nonburden analyses generated nonsignificant results. In GREM1, 33 variants were identified, 15 of which were rare. Of these, five were novel. Significant p-values were generated in three nonburden analyses. Segregation analyses revealed incomplete penetrance for all variants investigated.Conclusion Our study did not provide support for NOG being the causal gene at 17q22. However, the observation of a significant excess of rare variants in GREM1 supports the hypothesis that this is the causal gene at chr. 15q13. Because no single causal variant was identified, future sequencing analyses of GREM1 should involve larger samples and the investigation of regulatory elements. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc.Birth Defects Research Part A Clinical and Molecular Teratology 06/2014; 100(6). DOI:10.1002/bdra.23244 · 2.21 Impact Factor
Article: Whole Exome Sequencing of Distant Relatives in Multiplex Families Implicates Rare Variants in Candidate Genes for Oral Clefts[Show abstract] [Hide abstract]
ABSTRACT: A dozen genes/regions have been confirmed as genetic risk factors for oral clefts in human association and linkage studies, and animal models argue even more genes may be involved. Genomic sequencing studies should identify specific causal variants and may reveal additional genes as influencing risk to oral clefts, which have a complex and heterogeneous etiology. We conducted a whole exome sequencing (WES) study to search for potentially causal variants using affected relatives drawn from multiplex cleft families. Two or three affected 2°, 3° and higher degree relatives from 55 multiplex families were sequenced. We examined rare single nucleotide variants (SNVs) shared by affected relatives in 348 recognized candidate genes. Exact probabilities that affected relatives would share these rare variants were calculated given pedigree structures and corrected for the number of variants tested. Five novel and potentially damaging SNVs shared by affected distant relatives were found, and confirmed by Sanger sequencing. One damaging SNV in CDH1, shared by three affected second cousins from a single family, attained statistical significance (p=0.02 after correcting for multiple tests). Family based designs such as used in this WES study offer important advantages for identifying genes likely to be causing complex and heterogeneous disorders.Genetics 05/2014; 197(3). DOI:10.1534/genetics.114.165225 · 4.87 Impact Factor
Article: Inferring rare disease risk variants based on exact probabilities of sharing by multiple affected relatives[Show abstract] [Hide abstract]
ABSTRACT: Family based designs are regaining popularity for genomic sequencing studies because they provide a way to test co-segregation with disease of variants too rare in the population to be tested individually in a conventional case-control study. Where only a few affected subjects per family are sequenced, the probability any variant would be shared by all affected relatives - given it occurred in any one family member - provides evidence against the null hypothesis of a complete absence of linkage and association. A p-value can be obtained as the sum of the probabilities of sharing events as (or more) extreme in one or more families. We generalize an existing closed-form expression for exact sharing probabilities to more than two relatives per family. When pedigree founders are related, we show that an approximation of sharing probabilities based on empirical estimates of kinship among founders obtained from genome-wide marker data is accurate for low levels of kinship. We also propose a more generally applicable approach based on Monte Carlo simulations. We applied this method to a study of 55 multiplex families with apparent non-syndromic forms of oral clefts from four distinct populations, with whole exome sequences available for two or three affected members per family. The rare single nucleotide variant rs149253049 in ADAMTS9 shared by affected relatives in three Indian families achieved significance after correcting for multiple comparisons (p = 2 × 10(-6)). Source code and binaries of the R package RVsharing freely available for download at http://cran.r-project.org/web/packages/RVsharing/index.html CONTACT: firstname.lastname@example.com SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.Bioinformatics 04/2014; 30(15). DOI:10.1093/bioinformatics/btu198 · 4.62 Impact Factor
Article: Nonsyndromic Cleft Lip with or without Cleft Palate in Arab Populations: Genetic Analysis of 15 Risk Loci in a Novel Case-Control Sample Recruited in Yemen[Show abstract] [Hide abstract]
ABSTRACT: Background Nonsyndromic orofacial clefting (nsOFC) is among the most common of all congenital disorders and has a genetically complex etiology. Based on embryological and epidemiological data, the phenotype can be differentiated into nonsyndromic cleft lip with or without cleft palate (nsCL/P) and nonsyndromic cleft palate only, with nsCL/P being the most frequent form. Recent genetic research, predominantly performed in populations from Europe and Asia, has identified numerous genetic susceptibility loci for nsCL/P. As only few data are available concerning genetic susceptibility to nsCL/P in Arab populations, we investigated a newly recruited nsOFC sample from Yemen. Methods For each of the 15 currently known nsCL/P risk loci, the top single-nucleotide polymorphism (plus nine back-up variants) were genotyped in 242 nsCL/P cases and 420 healthy controls. ResultsSingle-marker association analysis revealed significant associations for four loci (8q24, 9q22, 10q25, 13q31). The strongest association was for the European high risk locus at 8q24 (Pcorrected = 5.09 × 10−4; heterozygous odds ratio = 1.74 (1.22–2.47), homozygous odds ratio = 2.47 (1.55–3.93). Five additional loci (1q32.2, 3q12, 8q21, 17q22, 20q12) showed nominal significance that did not withstand correction for multiple testing. Although the six remaining loci (1p22, 1p36, 2p21, 3p11, 15q22, 17p13) failed to reach nominal significance, the risk alleles were in the same direction as in the discovery studies. Conclusion The results suggest that four of the 15 analyzed nsCL/P risk loci which were identified in European and Asian ethnicities significantly confer risk for nsCL/P in Arab populations. Birth Defects Research, 2014. © 2014 Wiley Periodicals, Inc.Birth Defects Research Part A Clinical and Molecular Teratology 04/2014; 100(4). DOI:10.1002/bdra.23221 · 2.21 Impact Factor
Conference Paper: Genome-Wide Meta-Analysis of Nonsyndromic Cleft Lip With or Without Cleft Palate (NSCL/P) Identifies Multiple New Loci34th Annual Meeting of the; 04/2014
Article: A common microdeletion affecting a hippocampus- and amygdala-specific isoform of tryptophan hydroxylase 2 is not associated with affective disorders[Show abstract] [Hide abstract]
ABSTRACT: Objectives Copy number variants (CNVs) have been shown to affect susceptibility for neuropsychiatric disorders. To date, studies implicating the serotonergic system in complex conditions have just focused on single nucleotide polymorphisms (SNPs). We therefore sought to identify novel common genetic copy number polymorphisms affecting genes of the serotonergic system, and to assess their putative role in bipolar affective disorder (BPAD) and major depressive disorder (MDD).MethodsA selection of 41 genes of the serotonergic system encoding receptors, the serotonin transporter, metabolic enzymes and chaperones were investigated using a paired-end mapping (PEM) approach on next-generation sequencing data from the pilot project of the 1000 Genomes Project. For association testing, 593 patients with MDD, 1,145 patients with BPAD, and 1,738 healthy controls were included in the study.ResultsPEM led to the identification of a microdeletion in the gene encoding tryptophan hydroxylase 2 (TPH2), affecting an amygdala- and hippocampus-specific isoform. It was not associated with BPAD or MDD using a case–control association approach.Conclusions We did not find evidence for a role of the TPH2 microdeletion in the pathoetiology of affective disorders. Further studies examining its putative role in behavioral traits regulated by the limbic system are warranted.Bipolar Disorders 04/2014; 16(7). DOI:10.1111/bdi.12207 · 4.89 Impact Factor
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ABSTRACT: Nonsyndromic orofacial clefting (nsOFC) is a common, complex congenital disorder. The most frequent forms are nonsyndromic cleft lip with or without cleft palate (nsCL/P) and nonsyndromic cleft palate only (nsCPO). Although they are generally considered distinct entities, a recent study has implicated a region around the FOXE1 gene in both nsCL/P and nsCPO. To investigate this hypothesis, we analyzed the 2 most strongly associated markers (rs3758249 and rs4460498) in 2 independent samples of differing ethnicities: Central European (949 nsCL/P cases, 155 nsCPO cases, 1163 controls) and Mayan Mesoamerican (156 nsCL/P cases, 10 nsCPO cases, 338 controls). While highly significant associations for both single-nucleotide polymorphisms were obtained in nsCL/P (rs4460498: pEurope = 6.50 × 10(-06), pMayan = .0151; rs3758249: pEurope = 2.41 × 10(-05), pMayan = .0299), no association was found in nsCPO (p > .05). Genotyping of rs4460498 in 472 independent European trios revealed significant associations for nsCL/P (p = .016) and nsCPO (p = .043). A meta-analysis of all data revealed a genomewide significant result for nsCL/P (p = 1.31 × 10(-08)), which became more significant when nsCPO cases were added (pnsOFC = 1.56 × 10(-09)). These results strongly support the FOXE1 locus as a risk factor for nsOFC. With the data of the initial study, there is now considerable evidence that this locus is the first conclusive risk factor shared between nsCL/P and nsCPO.Journal of dental research 02/2014; 93(4). DOI:10.1177/0022034514523987 · 4.14 Impact Factor
Article: Evaluating eight newly identified susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a Mesoamerican population[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is among the most frequently occurring congenital malformations worldwide. The number of genetic loci identified as being involved in NSCL/P etiology was recently increased by a large genome-wide meta-analysis of European and Asian samples. This meta-analysis confirmed all six previously recognized genetic susceptibility loci and identified six novel ones. METHODS: To investigate which of these 12 loci contribute to NSCL/P risk in an independent sample of distinct ethnicity, we performed a case–control association analysis in a sample of the Mesoamerican population. A total of 153 individuals with NSCL/P (cases) and 337 unaffected controls were included. Top single-nucleotide polymorphisms (SNPs) at 8 of the 12 loci (1p22.1, 1p36, 2p21, 3p11.1, 8q21.3, 13q31.1, 15q22, and 20q12) were analyzed using mass spectroscopy and restriction-length-fragment polymorphism analyses. In a previous study, we had analyzed the remaining four NSCL/P susceptibility regions (IRF6, 8q24, 10q25, and 17q22) in the same sample. RESULTS: Single-marker association analyses applying allelic, dominant, and recessive models revealed nominal significant associations for four of the eight loci, with two additional loci showing at least a trend of association in the hypothesized direction. CONCLUSION: In combination with results from our previous study using the same sample, our data suggest that the majority of the known NSCL/P susceptibility regions identified to date also confer risk for this malformation in the Mesoamerican population. Birth Defects Research (Part A), 2013. © 2013 Wiley Periodicals, Inc.Birth Defects Research Part A Clinical and Molecular Teratology 01/2014; 100(1). DOI:10.1002/bdra.23209 · 2.21 Impact Factor
Article: Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test[Show abstract] [Hide abstract]
ABSTRACT: The advent of genome-wide association studies has led to many novel disease-SNP associations, opening the door to focused study on their biological underpinnings. Because of the importance of analyzing these associations, numerous statistical methods have been devoted to them. However, fewer methods have attempted to associate entire genes or genomic regions with outcomes, which is potentially more useful knowledge from a biological perspective and those methods currently implemented are often permutation-based. One property of some permutation-based tests is that their power varies as a function of whether significant markers are in regions of linkage disequilibrium (LD) or not, which we show from a theoretical perspective. We therefore develop two methods for quantifying the degree of association between a genomic region and outcome, both of whose power does not vary as a function of LD structure. One method uses dimension reduction to ''filter'' redundant information when significant LD exists in the region, while the other, called the summary-statistic test, controls for LD by scaling marker Z-statistics using knowledge of the correlation matrix of markers. An advantage of this latter test is that it does not require the original data, but only their Z-statistics from univariate regressions and an estimate of the correlation structure of markers, and we show how to modify the test to protect the type 1 error rate when the correlation structure of markers is misspecified. We apply these methods to sequence data of oral cleft and compare our results to previously proposed gene tests, in particular permutation-based ones. We evaluate the versatility of the modification of the summary-statistic test since the specification of correlation structure between markers can be inaccurate. We find a significant association in the sequence data between the 8q24 region and oral cleft using our dimension reduction approach and a borderline significant association using the summary-statistic based approach. We also implement the summary-statistic test using Z-statistics from an already-published GWAS of Chronic Obstructive Pulmonary Disorder (COPD) and correlation structure obtained from HapMap. We experiment with the modification of this test because the correlation structure is assumed imperfectly known.BMC Genetics 11/2013; 14(1):108. DOI:10.1186/1471-2156-14-108 · 2.36 Impact Factor
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ABSTRACT: Parent-of-origin (PofO) effects, such as imprinting are a phenomenon where the effect of variants depends on parental origin. Conventional association studies assume that phenotypic effects are independent of parental origin, and are thus severely underpowered to detect such non-Mendelian effects. Risk of orofacial clefts is influenced by genetic and environmental effects, the latter including maternal-specific factors such as perinatal smoking and folate intake. To identify variants showing PofO effects in orofacial clefts we have used a modification of the family-based transmission disequilibrium test to screen for biased transmission from mothers and fathers to affected offspring, biased ratios of maternal versus paternal transmission, and biased frequencies of reciprocal classes of heterozygotes among offspring. We applied these methods to analyze published genome-wide single-nucleotide polymorphism (SNP) data from ∼2500 trios mainly of European and Asian ethnicity with non-syndromic orofacial clefts, followed by analysis of 64 candidate SNPs in a replication cohort of ∼1200 trios of European origin. In our combined analysis, we did not identify any SNPs achieving conventional genome-wide significance (P<5 × 10(-8)). However, we observed an overall excess of loci showing maternal versus paternal transmission bias (P=0.013), and identified two loci that showed nominally significant effects in the same direction in both the discovery and replication cohorts, raising the potential for PofO effects. These include a possible maternal-specific transmission bias associated with rs12543318 at 8q21.3, a locus identified in a recent meta-analysis of non-syndromic cleft (maternal-specific P=1.5 × 10(-7), paternal-specific P=0.17). Overall, we conclude from this analysis that there are subtle hints of PofO effects in orofacial clefting.European Journal of Human Genetics advance online publication, 30 October 2013; doi:10.1038/ejhg.2013.235.European journal of human genetics: EJHG 10/2013; DOI:10.1038/ejhg.2013.235 · 4.23 Impact Factor
Article: Analysis of Susceptibility Loci for Nonsyndromic Orofacial Clefting in a European Trio Sample[Show abstract] [Hide abstract]
ABSTRACT: Nonsyndromic cleft lip with or without cleft palate (NSCL/P), the most common type of orofacial clefting, is one of the most frequent congenital defects. Based on epidemiological data, NSCL/P can be distinguished from nonsyndromic cleft palate only (NSCPO). Both phenotypes have a complex etiology and environmental and genetic factors are involved in their development. To date, genome-wide association studies have identified 12 genetic factors that increase the risk for NSCL/P in Europeans. Six of them have been independently replicated in samples derived from the same population. The aim of the present study was to replicate the remaining six NSCL/P risk loci in chromosomal regions 1p22.1, 1p36, 3p11.1, 8q21.3, 15q22.2, and 20q12 in a family-based sample of European descent. Each of the top-associated SNPs (single nucleotide polymorphisms) was genotyped in 343 NSCL/P and 266 NSCPO nuclear trios. Single-marker association analysis in the NSCL/P sample showed a significant association with SNP rs742071 (1p36, Pcorrected = 3.74 × 10(-3) ), which is located in the intronic region of PAX7, a gene known to be functionally implicated in craniofacial development. Two additional loci, 1p22.1 and 20q12, were nominally significant, but did not withstand correction for multiple testing. There was no evidence that the NSCL/P risk alleles contribute to the etiology of NSCPO, further supporting that these two subtypes of orofacial clefting are primarily etiologically distinct. © 2013 Wiley Periodicals, Inc.American Journal of Medical Genetics Part A 08/2013; 161(10). DOI:10.1002/ajmg.a.36141 · 2.05 Impact Factor
Top Journals
University of Bonn
Bonn, North Rhine-Westphalia, Germany
- Institute of Human Genetics
Ludwig-Maximilian-University of Munich
München, Bavaria, Germany
- Department of Internal Medicine II
Institute of Human GeneticsAmadavad, Gujarāt, India
University of Helsinki
Helsinki, Province of Southern Finland, Finland
- Department of Biological and Environmental Sciences
University of Bonn - Medical CenterBonn, North Rhine-Westphalia, Germany
Ruhr-Universität BochumBochum, North Rhine-Westphalia, Germany
Universität UlmUlm, Baden-Württemberg, Germany


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(PK Real Estate Utah, St. George, UT 84770)
Comments 7
Even a Peek-a-View will do! Many potential home buyers purchasing in the southern Utah area desire 360 degree breathtaking views from every window. That can be attained but costs more than the average sales price. Some opt for views from the yard or just a snippet from inside the home. While out...
(PK Real Estate Utah, St. George, UT 84770)
Comments 6
St George Utah Home for Sale | 1635 Maplewood Way 84790 | MLS# 15-167333 | New Price: $224,900 St. George, Utah was recently named by Money magazine as the #1 spot to retire for the great outdoors! This well maintained home with no HOA fees and the most affordable electrical rates in the state of...
(PK Real Estate Utah, St. George, UT 84770)
Comments 5
Single Family Homes: What will $200K-$400K buy in Washington County, Utah as of 7/06/2015? There are many factors that determine the price of a Home for Sale, such as: location, views, consumer interest, condition, upgrades, neighborhood amenities, living space and architecture. The criteria will...
(Re/Max First Realty)
Comments 2
Coral Canyon Home Sale Update-June 2015 Not familiar with Coral Canyon in St George Utah? Coral Canyon is a spectacular community with low HOA fees and wonderful amenities. Homeowners have access to indoor & outdoor pools for year round enjoyment, tennis courts, a state of the art fitness cente...
(Re/Max First Realty)
Comments 1
4th of July in Washington UT - 7/4/2015It's time for the annual Lions Club Breakfast and 4th of July activities in Washington Utah! Every year the Lions Club hosts the annual 4th of July Party in the Park (Veteran's Park-75 E Telegraph St. Washington UT 84780) All proceeds from the event are pu...
(Rindlesbach Homes)
Comments 0
Millcreek Homes 10 simple ways to save energy and money this summer: Set your air conditioner thermostat as high as comfortable – we recommend 78ºF or higher when you're at home, and 85ºF when you're gone. Keep inside air vents clear from furniture and other objects. Have your central ...
(Re/Max First Realty)
Comments 2
Gunlock Rodeo - July 2-4, 2015 | 4th of July Events in St George UTThe Gunlock Rodeo began in 1945 and has become a tradition for many southern Utah families each year. The event runs this year from Thursday, July 2 through Saturday, July 4, 2015 and begins each evening at 8 pm. The Gunlock Rod...
(PK Real Estate Utah, St. George, UT 84770)
Comments 10
Another home SOLD in Cedar City, Utah! 1096 S Bentley Boulevard, Cedar City, UT 94720 | SOLD! | $170,000 Well appointed home with 3 bedrooms, 2 bathrooms, 2 car garage and 1,680 total square feet of living space. This home has an open floor plan and vaulted ceilings, Corian countertops, custom c...
(Group 1 Real Estate)
Comments 0
How Much Money Will I Save by Owning a home?For all you renters out there in Tooele UT, here is a post you MUST read. Gene Riemenschneider of Home Point Real Estate posted this on Active Rain in early June. Gene shared 10 reasons why buying a home is better than renting. Most of the reasons w...
(Group 1 Real Estate)
Comments 0
It's getting easier to get a home loan in Tooele UT. Prices are still very attractive, interest rates are at historic lows, and banks and other lenders have eased qualification requirements over the last 12 months.I have reposted this article in hopes that if you are on the fence, this will spu...
(Group 1 Real Estate)
Comments 0
Here are 7 more homes for sale in Stansbury Park UT from $190,000. You may have noticed that there have been some great homes listed out here in the last few weeks. If you are not familiar w/ Stansbury Park, I invite you to take a drive out this way and see what your money will buy in a very dy...
(PK Real Estate Utah, St. George, UT 84770)
Comments 8
Five reasons southern Utah has it all! 1. Named one of the safest states in the U.S. Saint Gorge, Santa Clara, Ivins and Hurricane, Utah voted one of the safest cities to live in the state of Utah by Safewise and 6th safest state by Wallethub. WalletHub also ranked St. George, Utah in the top thr...
(PK Real Estate Utah, St. George, UT 84770)
Comments 21
Lucky horse! Passing by and admiring this work of art that sits along a busy roadway in St. George, Utah, I often thought of stopping and taking a snapshot of this beautiful rendition of a work horse. Finally, I did. This metal masterpiece had to be crafted by a horse lover! I am a fan of this l...
(Group1 Real Estate, selling houses in Salt Lake City Utah )
Comments 0
Tips On Prepping Your Salt Lake home To SellEveryone that is thinking of listing their house, needs a few basic guidelines and maybe even tips on prepping your Salt Lake home to sell. Almost everyone knows what to do about making a good first impression, but somehow between the listing agreement ...
(Group1 Real Estate, selling houses in Salt Lake City Utah )
Comments 0
Salt Lake Home Loans- Fixed or Adjustable?One of the most common questions I get is, what's the best Salt Lake home loan, fixed or adjustable? There rarely is a good answer without going onto a fact finding conversation with the home buyer.I generally tell the client that they need to talk to a l...
(Group1 Real Estate, selling houses in Salt Lake City Utah )
Comments 0
One of the most asked questions I get from Salt Lake buyers is what is the difference between an FHA loan and Conventional financing. I found a pretty good article that explains those differences and some of the pros & cons of each. To re-cap the article, here are some of the highlights. Both ar...
(Group1 Real Estate, selling houses in Salt Lake City Utah )
Comments 0
Boost Resale Value in your Salt Lake Home Selling Your Home in 2015? Boost Your Resale Value in your Salt Lake home with These Three Inexpensive Renovations To get top dollar for your home, renovations may be necessary. However, some renovations can prove costly and they don't always add value to...
(Re/Max First Realty)
Comments 2
Entrada Golf Community Homes for Sale, St George UT, 6/26/15Looking for houses in Entrada Golf Community in St George Utah? Then follow this link for details of Entrada Golf Course Community Homes for Sale.Entrada is an exclusive guard gated community in St George Utah offering it's residents a ...
(Re/Max First Realty)
Comments 2
Fishing in St. George UT– Local Man Catches Piranha RelativeFishing in St. George UT is some of the best fishing in the state. Southern Utah is well known by fishing anglers from all around for the quality of fishing you will experience when fishing in St. George UT. Whether you are looking for r...
(PK Real Estate Utah, St. George, UT 84770)
Comments 18
We have a WINNER! MONEY names St. George, Utah best place to retire for the great outdoors! Low tax rate, cost of living and mild winters all play a part in St. George, Utah being featured as an enticing place to retire. Not to mention the veritable outdoor playground waiting to be discovered! I...
(Rindlesbach Homes)
Comments 0
Millcreek Homes for Sale Millcreek Venture Outdoors June 26 - Glamping! in the Great Urban Outdoors / The Sponge Bob Movie (PG) Fri 6:00 pm - 11:00 pm Location: Big Cottonwood Regional Park 4300 S. 1300 E., 84109 Salt Lake City, UT, US June 26, 2015 - Big Cottonwood Park - 6pm-Twilight Mo...
(Re/Max First Realty)
Comments 2
Vacation Destination - St. George Day SpasYour next vacation destination should include St. George Day Spas. If you are looking for a complement to a perfect vacation that includes energizing activities, lots of recreation, fitness, fresh air and clear skies, St. George Day Spas is just what you ...
(Re/Max First Realty)
Comments 3
Fourth of July in Hurricane Utah-July 4, 2015Lots of fun events are planned for the Fourth of July in Hurricane Utah this year!The fun begins at 7 am with the Lions Club Breakfast held at the Community Center and benefits the Hurricane Lions Club. Breakfast will be served early enough so that th...
(Group1 Real Estate, selling houses in Salt Lake City Utah )
Comments 1
It's more important than ever to know how to find the newest Salt Lake listings. With the good buys being snapped up in just days in some of the cities in Salt Lake County, you need to find homes for sale as soon as they hit the MLS.We've made it easy for you. Each day we load & display every ho...
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IN THE MATTER OF THE ESTATE OF ALICE M. KING, Late of Ferguson Township, Centre County, Pennsylvania Thomas D. King 909 West Fairmount Avenue, State College, PA 16801 Executor Jeffrey M. Bower, Esq., BOWER LAW ASSOCIATES 403 South Allen St., Suite 210, ...More info Email a friend
ESTATE NOTICE BROKLOFF, ANNA K., late of State College Borough, Centre County, Pennsylvania, Executor - Ned A. Brokloff, 3008 Patuxent Overlook Ct., Ellicott City, MD 21042. Attorney - Louis T. Glantz of Glantz, Johnson & Associates, 1901 E. College Avenue...More info Email a friend
ESTATE OF ESTATE OF KEITH E. FREEMAN, late of State College Borough, Centre County, Pennsylvania, Deceased. Kimberly S. Freeman, Executor, 155 West Lytle Ave., State College, PA 16801 814-880-1130 Fredrick Farber, Esquire, Attorney, 110 Regent Court, Suite...More info Email a friend
Estate of: Relda M. Blaker Late of: College Township, PA Died: April 14, 2015 Co-Executor: Alfred B. Blaker, Jr. 154 Fairlawn Ave. State College, PA 16801 Co-Executor: Michael A. Blaker 955 Pine Grove Rd. Hanover, PA 17331 Attorney: Chad J. Julius, ...More info Email a friend
May 19, 2015 This statement is a condensation of the annual audited financial statements of State College Borough Water Authority for the year 2014 and is published in accordance with Pennsylvania Act 22 of 2001. Complete copies of the annual audited financial...More info Email a friend
NOTICE OF EXECUTORS Letters Testamentary in the Estate of Nancy M. Heverly, Late of Liberty Township, Centre County, Pennsylvania, have been granted to the undersigned, who requests all persons having claims or demands against the estate of said decedent...More info Email a friend
PUBLIC HEARING NOTICE The Benner Township Board of Supervisors will hold a public heairng on July 6, 2015, beginning at 7:00 p.m. at the municipal building located at 1224 Buffalo Run Road, Bellefonte, PA 16823 on proposed Ordinance 126. This proposed...More info Email a friend
Helena Chemical Company will be applying restricted use chemicals at various times to agricultural cropland in Blair, Cambria, Centre, and Huntingdon counties. For additional information contact Jim Sebulsky or Joe Berry at Helena Chemical Company, PO Box...More info Email a friend


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Email List
SM Mirror TV
Santa Monica Beat
Editor-In-Chief Brenton Garen discusses Cirque du Soleil's show "Totem" that opens this Friday, Jan. 17 at the Santa Monica Pier.
Santa Monica Beat
WestsideToday.com presents Westside TV, the easiest way to get local news, entertainment and all things on the Westside. Coming 2014.
Santa Monica Beat
LOBSTER TRIVIA: See the answer to how many tourists visit Santa Monica annually.
Santa Monica Beat
This week, Paul Sand founder of the West End Theatre stops by to discuss the opening of the new theatre on the Santa Monica Pier.
News, Ucla, Westwood
UCLA Stats For Fall 2015 Semester: 16,027 Prospective Freshman Offered Admission
Posted Jul. 2, 2015, 12:44 pm
UCLA has offered admission to 16,027 prospective freshmen for the fall 2015 semester -- representing 17.3 percent of applicants -- along with 4,905 transfer students, the university announced today.
News, Santa Monica College, Santa Monica, Smc
SMC's Drescher Planetarium Features Reusable Rockets & More In July
Posted Jul. 2, 2015, 9:07 am
The Santa Monica College John Drescher Planetarium invites community members to come find out what the latest developments are in the quest for a reusable rocket, and enjoy a preview that prepares you to make the most of the Perseid Meteor Shower coming this month.
News, Parks, Santa Monica
Did You Know July Is Parks Month? City Says Rediscover The Great Outdoors
Posted Jul. 2, 2015, 8:59 am
Although Santa Monica is internationally known for its iconic beach and world-class public spaces, the Wellbeing Project recently revealed that few locals find the time to get out and enjoy their own community's park and recreation resources.
News, Santa Monica, Traffic
Chain-Reaction Vehicle Crash On 405 Freeway Southbound In West L.A. Cleared
Posted Jul. 2, 2015, 8:26 am
The wreckage from a chain-reaction collision involving four or five vehicles, which temporarily blocked the numbers 4 and 5 lanes of the southbound San Diego (405) Freeway at Santa Monica Boulevard in West Los Angeles this morning, has now been cleared, according to the California Highway Patrol.
News, Holiday, Santa Monica
Where To Watch July 4 Fireworks On The Westside
Posted Jul. 2, 2015, 8:20 am
While the City of Santa Monica does not have a fireworks display on the 4th of July, there are many professional fireworks displays and events planned in and around the surrounding area.
News, Seven Days, Celebrity, Santa Monica, Film
Mark Ruffalo: Life At Home & The Psychological Challenges Of Acting
Posted Jul. 1, 2015, 12:30 pm
Any time you mention Mark Ruffalo's name to anyone, the response is always, "He seems like a really nice guy;" or "He seems so genuine and not full of himself;" or "I love his acting;" or "I really love that guy." And so it goes.
News, Fire Department, Malibu, Santa Monica
Firefighters Rescue Missing Woman From SUV That Crashed Off Malibu Hillside
Posted Jul. 1, 2015, 10:33 am
A woman reported missing from Simi Valley was found inside her crashed SUV today about 50 feet down the side of a hillside north of Malibu and taken to a hospital with what were described as moderate injuries.
News, Beach, Santa Monica, Brock On Your Block
Brock On Your Block: The Importance Of World Oceans Day
Posted Jul. 1, 2015, 10:07 am
Brock on Your Block host Phil Brock speaks with Marion Clark, Programs Director for Surf Academy and the Surf Bus Foundation, about World Oceans Day.
News, Santa Monica, Weather
"Flex Alert" Issued For Today As Hot Spell Grips Southland
Posted Jul. 1, 2015, 9:55 am
With a heat wave gripping the Southland and power demand on the rise, the manager of the state's energy grid issued a "flex alert," urging residents to conserve electricity between 2 and 9 p.m. today -- a warm, muggy day when showers and thunderstorms are possible -- to reduce strain on the system.
Life And Arts, Seven Days, Santa Monica, History
Relive The Santa Monica Road Races On Friday, July 17
Posted Jul. 1, 2015, 9:37 am
Santa Monica will relive the historical 1911 Santa Monica Road Races on Friday, July 17 from 5 pm to 8 pm at the Fairmont Miramar Hotel & Bungalows who is sponsoring the event to benefit the Santa Monica History Museum.
News, Parks, Santa Monica
Tongva Park Named One Of Six Finalists For Global Award Of Excellence
Posted Jul. 1, 2015, 9:32 am
The City of Santa Monica and James Corner Field Operations announced that Santa Monica's Tongva Park/Ken Genser Square Project has been selected as one of six finalists in the Urban Land Institute's Global Award of Excellence For Urban Open Space.
News, Apb, Santa Monica, Police Department
Female Jogger Assaulted In Early Morning Attack On Santa Monica Beach
Posted Jul. 1, 2015, 9:15 am
A female jogger on an early morning run had the fright of her life on Saturday, June 20, after an 18-year-old man tackled her to the ground for no apparent reason.
News, Health, Santa Monica
Considering Alcohol, Drug Addiction Treatment? Matrix Institute Has 30 Years Experience
Posted Jul. 1, 2015, 9:09 am
When Matrix Institute on Addictions founders Jeanne L. Obert, Michael McCann and Richard Rawson, Ph.D first opened its doors to drug and alcohol addiction patients in 1984, neither of them could have imagined the significant impact they would make in the years ahead.
News, Health, Santa Monica
State Senator Ben Allen's Mandatory Vaccination Bill Signed Into Law
Posted Jun. 30, 2015, 1:11 pm
Almost all school children in the Southland and across California will be required to be vaccinated against diseases such as measles and whooping cough under legislation signed into law today by Gov. Jerry Brown.
News, Santa Monica, Exposition Light Rail
Metro Expo Line Extension To Santa Monica About 90 Percent Complete
Posted Jun. 30, 2015, 9:41 am
The Metro Expo Line extension from Culver City to Santa Monica is about 90 percent complete and on track to open by spring 2016, connecting downtown Los Angeles to the beach in a route Mayor Eric Garcetti on Monday called "from Grand to the sand."
News, Santa Monica College, Santa Monica, Smc
Santa Monica College's Hallmark Black Collegians Program Turns 25
Posted Jun. 30, 2015, 9:39 am
1989 marked the beginning of the end of apartheid in South Africa, and at Santa Monica College, other revolutionary things were happening. The idea of a special program was born, which would provide smaller classes taught by phenomenal instructors with a focus on African-American culture where possible.
News, Santa Monica, Smmusd, Lincoln Middle School
New Assistant Principal Appointed At Lincoln Middle School
Posted Jun. 30, 2015, 9:23 am
The SMMUSD Board of Education approved the appointment of Stefanie Suffolk as the new assistant principal of Lincoln Middle School at its special meeting on Monday.
News, Malibu, Smmusd
New Assistant Principal Appointed For Malibu High School (For Malibu Middle School)
Posted Jun. 30, 2015, 9:20 am
The SMMUSD Board of Education approved the appointment of Patrick Miller as the new assistant principal of Malibu High School working with the middle school program at its special meeting on Monday.
News, Malibu, Smmusd
From Hawaii To Malibu High School, New Principal Appointed
Posted Jun. 30, 2015, 9:18 am
The SMMUSD Board of Education approved the appointment of Dr. Brandon Gallagher as the new principal of Malibu High School at its special meeting on Monday.
News, Apb, Santa Monica, Police Department
Bail Not Granted To Santa Monica Man For Pushing Pregnant Girlfriend To Ground
Posted Jun. 30, 2015, 9:04 am
Bail was not granted to a Santa Monica man on Friday, June 19, after the 21-year-old pushed his pregnant girlfriend to the ground during an argument. Officers of the Santa Monica Police Department were called out to the Santa Monica-UCLA Hospital, located at 1225 15th Street, at 4:40 pm on this day in response to a call that dispatch had received from a social worker.


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A win for common sense
Hone Harawira's "feed the kids" bill has been defeated in parliament.
The Mana Movement leader introduced it before last year's election, campaigned on it, and then lost his seat.
It would have lapsed if Green Party co-leader Metiria Turei hadn't picked it up.
The bill would have provided government-funded breakfasts and lunches in all decile one and two schools.
It gained strong support from opposition parties and child welfare advocates, but the government never accepted it.
"We would be providing meals that are provided by the vast bulk of parents and caregivers already," Prime Minister John Key said when the bill first came to parliament.
"We should expect parents to feed their children properly and the vast majority of them do." Read more »


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Tarah is constantly working to progress the sport and makes it look better than any guy could ever hope to.
This toque-wearing Canuck has managed to get a whole lot of west coast style integrated into this month's Rider Link.
Is Mr. Hair the best all-around competitive wakeboarder in the world? We've got some compelling evidence to support that theory.
The proprietor of The Boarding School has found the fountain of youth and continues to blow minds with his big and smooth riding!
After exhaustive research, Wake Devil RJ Pabon comes up with the top ten collegiate wakeboarders for the 2012-2013 school year.
We spent a day in Orlando with Byerly, Watson, McKee and Czeschin checking out the new Nautique Surf System.
JB's got a reputation for bringing a lot of creativity to the sport through both his riding and his video productions.
Randall, Dean, Chad, Grubby, Amber, Dallas, Trever, Tarah and Cobe making the Malibu and Axis boats look even better!
The NFL calls them future hall-of-famers. Our sport needs a similar title so that we can properly categorize Melissa.
After a back injury took her out at Nationals in 2012, Nicola has begun the long climb back to the top of the mountain.
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Auto Components
Company Overview of Nuvera Fuel Cells, Inc.
Executive Profile
Lawrence D. Burns Ph.D.
Director, Nuvera Fuel Cells, Inc.
|Total Calculated Compensation
|This person is connected to 1 Board Members in 1 different organizations across 1 different industries.
See Board Relationships
Dr. Larry Burns serves as Senior Advisor to the Chairman of Hess Corporation. Previously, Dr. Burns served as Vice President of Research & Development and Strategic Planning at General Motors Company from May 1998 to July 2009. He is also a member of VantagePoint Venture Partners' CleanTech Advisory Council and a contractor to the National Renewable Energy Laboratory. Dr. Burns has been a Director of Nuvera Fuel Cells, Inc. since December 2009. He serves as a Director ...
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129 Concord RoadPhone: 617-245-7500
Billerica, Massachusetts 01821
United States
Fax: 617-245-7511
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Summery Passion Fruit Sangria
4 comments | Leave Comment
Summery Passion Fruit Sangria
Is there a better summer drink than a fruity sangria?? Perfect for summer! We gave it a little twist by adding stone fruit, that pairs beautifully with the floral passion fruit taste. Add Ice cubes right before serving the sangria. If you plan ahead you can make orange juice ice cubes and add them to the sangria instead of plain ice cubes. Allow the sangria to sit for a few hours in the refrigerator before serving. Serve Cold.
- Prep Time : 5 min
- Ready Time : 5 min
- 2 cups Morad Passion Fruit Wine
- 1 1/2 cups Italian Sparkling Water
- 1/4 cup Orange Juice
- 2 tablespoons Fresh Squeezed Lemon Juice
- 1 peach
- 1 nectarine
- 1 plum
- 1 lime
- 2 cups ice cubes
Slice the fruit.
In a large pitcher combine wine, orange juice, lemon juice and sparkling water.
Add Sliced fruit.
Chill in the refrigerator for a few hours.
Add ice before serving.
Similar Recipes
About May I have that recipe
4 Responses to Summery Passion Fruit Sangria
love the recipes keep them comeing thanks
I live in Israel. Can one get this passion fruit wine here?
I love Kosher Food! No I'm not Jewish but he was adopted me as I did him. He got me hooked on Kosher Food. After I joined your recipe of the Day, as you recommended on Joy of Kosher, I was thrilled with the luck of finding the dishes I could only dream about. Keep up the good work.
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Pareve , Drinks , Fourth of July, Passover Recipes, Purim , Spanish , Make Ahead, No Cook, Quick (under 30 minutes) , Fruit , Morad Wines


text:
Deakin home > Deakin Research > IFM
Graphene coatings make steel corrosion-resistant
IFM researchers have grown graphene flakes directly onto stainless steel, improving the metal's resistance to corrosion.
Miracle fuel
IFM researchers are helping to make hydrogen extraction from water more feasible.
Not just a flight of fancy
IFM researchers get closer to shape-morphing aircraft wings.
Deakin showcases 3D sheet metal forming at Numisheet 2014
Deakin's Professor Jeong Whan Yoon chaired the organising committee for Numisheet 2014.
Master of his destiny
Deakin right fit for (auto)motivated Mohan Setty.
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|Grain refinement of titanium alloys through novel thermomechanical processing
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|The role of thermo-mechanical processing on nanobainitic phase transformation characteristics
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|Temperature and grain orientation dependence of mechanical twinning in a high Manganese TWIP steel
|Debasis Poddar
|The interaction between the precipitation and dislocation substructure during multipass deformation in an austenitic Fe-30Ni-0.1C-).1Nb model alloy
|Shahriar Reza
|Nano-scale precipitation in high-strength steels
|Mahendra Ramajayam
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Lobbying Transparency via RTI Laws
This document sets out the classes of information that should be made available by public bodies in order to get a full picture of the influence of interest groups, particularly lobbyists, on governmental and […]
New lobby transparency civic-tech tools reveal corporate dominance of the Brussels bubble
Madrid, 25 June 2015 – The RTI community celebrated this week the launch of two groundbreaking online tools that enable citizens to monitor the interactions between high-level European Commission officials and lobbyists in the […]
Over 100 NGOs urge EU Commission to make the lobby register legally binding
Brussels, 11 May 2015 – The Alliance for Lobbying Transparency and Ethics Regulation (ALTER-EU) [1] has urged European Commission Vice President Frans Timmermans to take strong and urgent action to create a high-quality and […]
Full Lobby Transparency campaign launched with ALTER-EU debate at the Parliament
This article was originally published on ALTER-EU.org: http://www.alter-eu.org/alter-eus-new-campaign-launched-with-transparency-debate-at-the-parliament
Brussels, 29 April 2015 – ALTER-EU launched its new campaign Full lobby transparency now! with a high-profile debate. Held at the European Parliament, panellists included ALTER-EU members […]
New lobby transparency civic-tech tools reveal corporate dominance of the Brussels bubble
Madrid, 25 June 2015 – The RTI community celebrated this week the launch of two groundbreaking online tools that enable citizens to monitor the interactions between high-level European Commission officials and lobbyists in the Brussels bubble:
» LobbyFacts.eu, created by […]
European Commission urged to act to improve transparency
Madrid, 24 June 2015 – In a letter to European Commission Vice-President Timmermans as part of an ongoing dialogue, Access Info Europe has called for action to improve EU transparency in law and in practice. The pro-transparency organisation stressed […]
European Commission fails to prove the need for its postal addresses policy
Madrid, 19 June 2015 – Access Info Europe this week expressed concern at the European Commission's insistence on maintaining its obstructive requirement for all documents requesters to provide their postal addresses, after the Commission admitted in response to parliamentary […]
Access Info Europe welcomes European Ombudsman investigation into excessive secrecy of "trilogues"
Madrid, 28 May 2015 – Access Info Europe today welcomed the decision by the European Ombudsman to investigate the lack of transparency of "trilogues", the informal and secretive negotiations between the EU's Commission, Council and Parliament by which much […]
AsktheEU.org and the EU Institutions: The Challenge of running an Alaveteli Request Platform
Madrid, 22 May 2015 – Following AlaveteliCon 2015 in Madrid on 19-20 May, Access Info Europe's director Helen Darbishire, reflects on 3.5 years of running the AsktheEU.org website for making documents requests to the European Union.
In particular she […]
Civil society secures European Parliament support for transparency of mineral imports
Madrid, 22 May 2015 – The European Parliament this week took a strong stance in favour of binding rules on transparency for the mineral extraction industry, following a letter sent to MEPs signed by 157 civil society organisations, including […]
Access Info presenta sus recomendaciones en respuesta a la consulta pública del Consejo de Transparencia
Madrid, 9 de junio de 2015 – Access Info Europe ha enviado hoy sus aportaciones a la Consulta abierta por el Consejo de la Transparencia y Buen Gobierno (LTAIGB) sobre su Plan Estratégico 2015-2020.
Las […]
El Gobierno afirma que el silencio administrativo no supera el 1% en los últimos cinco meses
Post originalmente publicado en El Blog de Tuderechoasaber.es
Madrid, 6 de mayo de 2015 – Desde que Access Info Europe empezó a monitorear en 2005 el nivel de respuesta de las instituciones públicas españolas a […]
High levels of administrative silence leave Spanish FOI requesters in the dark
Madrid, 22 April 2015 – Levels of administrative silence remained high in Spain in 2014, in the year running up to Europe's newest transparency law coming into force, according to a report published by […]
El defensor del Pueblo reconoce que el Portal de Transparencia puede tener un efecto disuasorio sobre el derecho de acceso a la información
[ACTUALIZACIÓN. 5 de mayo de 2015 – Access Info Europe ha respondido con una nueva carta al Defensor del Pueblo exponiendo nuevas pruebas de lo denunciado en su primera queja, enviada el 17 de […]
Transparencia: ¿lema o realidad?
25 June 2015, 9:30
Sala de Conferencias del Instituto Nacional de Administración Pública (INAP) c/ Atocha 106, Madrid
Transparencia y gobierno abierto: realidades y aplicación práctica
22-24 June 2015
Península de la Magdalena, Santander
Wired Next Fest 2015 – "Il segreto di Stato al tempo degli Open Data"
23 May 2015, 5 pm
WNF Main Dome, Giardini Indro Montanelli, Corso Venezia 55, Milan, Italy
Your Right to Ask … Your Right to Know!


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Town Square
Police Activity at Victoria's Salon on Thursday
Original post made by McGruff, Downtown, on May 13, 2011
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Bidding my Maverick Bye-Bye
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Bellissima! DuWop's Beauty Blade
Bellissima! DuWop's Beauty Blade
To look great, you've got to have the right tools of the trade. Consider the latest creation from DuWop, the Beauty Blade ($11).
Not only does this chic-looking sharpener help create cutting-edge eye and lip lines, but it's also the world's first sharpener with anti-bacterial polymers built into the hardware. That means this gadget cleans itself! It also means that your eyes are protected against unwanted germs and bacteria. After each twist of your wrist, your pencil is more sanitary than ever.
The sharpener fits classic thin pencils as well as the new chunky pencils. It also has a flip-tip Lucite hatch that covers the blade and helps contain your shavings. Nice and neat — how sweet!
POPSUGAR, the #1 independent media and technology company for women. Where more than 75 million women go for original, inspirational content that feeds their passions and interests.


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New EU Data Protection Regulation
Analysis and noter-up of the proposed new EU Data Protection Regulation, tracking comments and amendments made in the course of the EU legislative process.
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An explanation and discussion of what binding corporate rules are and how they protect personal data.
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Letters of claim for infringements of patents, trade marks, copyright, design right and registered designs, and for passing off and breach of confidence.
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Access your favourite English law, Scots law and tax titles from publisher Bloomsbury Professional.
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- High Court confirms genuine use of Community trade mark requires use in more than one member state
- EU General Court rules toys and sporting goods dissimilar in trade mark opposition
- IP Enterprise Court finds patent for on-board vehicle load measuring device invalid
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