text: GALLERIES Whitney Able Getty Images" data-filename="galleries/whitney-able/picture-24.html" > Getty Images" data-filename="galleries/whitney-able/picture-25.html" > Back to Top ▲ Whitney Able Whitney Able Whitney Able Photos AskMen Editors Share on Facebook Share on Twitter 0 Shares Next Page Comments Show Comments More Like This Promoted Around the Web Special Features Special Feature 100 Ways To Look Better Than You Do Now. Smooth Up, Man. Read More Special Feature Over 100 Ways To Make This The Most Jaw-Dropping Year Of Your Life Read More Special Feature From Dating To Fitness, Over 75 Ways Men Are Winning 2015 Read More ad

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Monday, July 6, 2015
Act Fast! Limited Space Open for Pitch Party '13
Animag's 12th annual Pitch Party Contest has only a few pitch slots open for the 2013 competition, so aspiring series creators and brilliant toonsters must act fast to be included. In ... Continue Reading →
Doug TenNapel Kickstarts New Game Project
Animation veteran Doug TenNapel, creator of TV shows Earthworm Jim, Catscratch and the groundbreaking game The Neverhood, has launched a project called Armikrog in partnership with ... Continue Reading →
Peter Clarke Exhibit Launches Center Stage Gallery
The Creative Talent Network, host of the annual popular CTN Animation Expo will open a new gallery in Burbank devoted to the art of professionals who work in the animation industry. ... Continue Reading →
Komixx, Gotham Group Launch Joint Venture
Komixx Entertainment Inc., the U.S. subsidiary of London-based Komixx Ent. Ltd., is teaming up with Los Angeles management and production company the Gotham Group to create a new joint-venture ... Continue Reading →
Carl England Assumes MD Role at Platinum
Nigel Stone, CEO of U.K.-based indie film and kids' TV production studio Platinum Films, has announced that Carl England has been appointed as the company's new managing ... Continue Reading →
Amazon and Fremantle Execs to Keynote at MIPCOM
French TV confab MIPCOM today announces the initial line-up for the Media Mastermind conference program at the Palais des Festivals' Grand Auditorium in Cannes. The confirmed speakers ... Continue Reading →
Former Mill Artists Form New Milk VFX House
Six former members of vfx house The Mill have formed a new London-based vfx studio called Milk. The new shop will specialize in innovative 3D effects and character animation for both ... Continue Reading →
Platige Image Offers Details About New Movie
Award-winning Polish animation and vfx studio Platige Image has unveiled new information and a trailer for its upcoming animated feature Another Day of Life. Based on the book by Ryszard ... Continue Reading →
'Epic,' 'Croods' Continue to Draw Audiences
Although audiences didn't respond to M. Night Shyamalan's After Earth this past weekend (the movie opened at No. 2 with a $27 million at the box office domestically), families are ... Continue Reading →


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NIKE Business Systems Analyst Interview Questions
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
Interviews for Top Jobs at NIKE
- Sales Associate (32)
- Nike Athlete (32)
- Seasonal Athlete (26)
- Intern (19)
- Athlete (15)
- Retail Sales Associate (12)
- PT Athlete (8)
- Project Manager (7)
- Financial Analyst (6)
- Part-time Athlete (6)
- Business Systems Analyst (6)
- Part Time Athlete (5)
- Sales Representative (4)
- Part Time Sales Associate (4)
- Director (4)
- Internship (4)
- Marketing (3)
- Human Resources (3)
- Summer Intern (3)
- Sales (3)
- Engineer (3)
- Coach (3)
- Sales Athlete (3)
- Athlete - Part Time (2)
- Program Manager (2)
- Brand Manager (2)
- Digital Director (2)
- Customer Service (2)
- Area Manager (2)
- Senior Business Systems Analyst (2)
6 Candidate Interview Reviews Back to all InterviewsSort: Popular Date Difficulty
Helpful (6)
Business Systems Analyst Interview
met with recruiter than face to face with manager
Interview Questions
- why do you want to work at nike Answer Question
Other Interview Reviews for NIKE
Business Systems Analyst InterviewNo OfferNeutral ExperienceAverage Interview
I applied through a recruiter. The process took 4 weeks – interviewed at NIKE (Portland, OR) in November 2013.
Phone interview
Interview Questions
- Mostly Qs were around my previous work experiences. Sounded like they were looking for someone with experience from a more matured organization as their's. Rich customer interaction experience required. Answer Question
Business Systems Analyst InterviewNo OfferNeutral Experience
I applied through a recruiter. The process took 5 days – interviewed at NIKE.
Panel interview of 4 people
Interview Questions
- What was your most memorable mistake and how did you handle it. Answer Question
Helpful (1)
Business Systems Analyst InterviewAccepted OfferPositive ExperienceAverage Interview
I applied through an employee referral. The process took 4+ weeks – interviewed at NIKE (Portland, OR) in June 2012.
The whole process went very professional. The recruiter contacted me and set up a 30 min briefly interview. He kept me within the entire process in the loop and provided me with all information about the current status of the process immediately.
Interview Questions
- All question as you would expect withing a professional job interview... Answer Question
Helpful (2)
Business Systems Analyst InterviewNo OfferPositive ExperienceEasy Interview
I applied through a staffing agency. The process took 2 weeks – interviewed at NIKE (Beaverton, OR) in October 2011.
Received call from recruiter that found my resume posted on a job board. I answered basic background questions regarding my experience and then if I was interested in a contract job in Beaverton, OR.
The recruiter set up a phone interview with 3 people that lasted 45 minutes.
The call was right on time, and included the hiring manager, the hiring managers' supervisor, and the person leaving the position they were trying to fill.
Interview Questions
- Tell me about your background and how it applies to this position? Answer Question
- Would you commute or would you relocate if offered this position? Answer Question
Business Systems Analyst InterviewNo OfferNeutral ExperienceEasy Interview
I applied online. The process took 1 day – interviewed at NIKE in August 2010.
Interview consisted of a 20 minute phone screening from a recruiter with Nike.
Interview Questions
- How many years of experience do you have leading a team of 15 or more? Explain your role. Answer Question
Is this helpful? The community relies on everyone sharing – Add Anonymous Interview Review


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Brothers: A Tale of Two Sons coming to PS4, & Xbox One this summer
BAFTA-winning adventure getting remaster treatment.
Broken Sword 5 coming to PS4 & Xbox One this summer
Improved animation and sound, character gallery and more added to console release.
Cambridge college students to exhibit at E3
Teenagers take on major players at next week's main event.
Mirror's Edge Catalyst trademarked in Europe
UPDATE: Teaser image released, but is it the name of next year's game?
PES Club Manager out now on iOS & Android
3D match day elements powered by the PES console game engine.
King Magni Bronzebeard coming soon to Hearthstone
One of a host of new Heroes which will be sold for $9.99.
Star Wars: Uprising bridges the gap between Return of the Jedi & The Force Awakens
Heading to mobile devices this autumn.
Hitman: Sniper out now on iOS & Android
A leaderboard-driven sandbox game in which Agent 47 guns down targets.
Her Story will launch June 24
Does for games "what True Detective did for the cop show and what Serial did for the true crime podcast," says creator.
Queen, Wolfmother, Weezer and Alice in Chains tracks confirmed for Guitar Hero Live
10 new tracks added to the confirmed track list.
Geometry Wars 3 out now on iPad, iPhone and iPod touch
Includes two exclusive stages for iOS and Facebook high score challenges.
EA Mobile exec Frank Gibeau leaves after 23 years
But mobile will remain a 'core focus' for EA, CEO stresses.


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Lydia is a sweet two-year-old black and white cat who is ready to go to her forever family. She is perfectly balanced and great with children of all ages. She loves to run around and play with toys, however, she also enjoys being close to people and curling up on your lap. If you give her a good belly rub or a nice scratch behind her ears, she will purr all day! Lydia is spayed, micro chipped and up-to-date on vaccinations. Visit her today at the Kentucky Humane Society's Main Campus, or call 502.366.3355 for additional information. View all adoptable pets at www.kyhumane.org.
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Hollywood Matchmaker
Who Should Zac Efron Date?
By Molly McGonigle
It's been almost two years since Zac Efron and Vanessa Hudgens split. And while she has moved on to a new relationship, Zac hasn't taken the plunge and gotten serious with anyone yet. In honor of Zac's 25th birthday on Oct. 18, we're helping him out by combing through Hollywood to find the perfect ladies to get him back in the dating game. Click through to cast your vote on who his next lady friend should be.
Perhaps we should look no further than Zac's "The Lucky One" co-star Taylor Schilling. Luck must be on Taylor's side, because these two had to film lots of sexy love scenes -- and did so with obvious chemistry between them. Even though she says it was easy to do sex scenes together because they became friends quickly, we think that their on-screen connection would make a great real-life love story too.Sign up for celebrity breaking news!Please enter a valid email addressBy signing up I accept the Terms of Use and Privacy PolicyThanks for subscribing!Show CommentsNextWhen using Facebook Connect your image and name may display on Wonderwall. All Privacy Settings are controlled by Facebook
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UP NEXTFun in the Sun
From Elle
From Crowd Ignite


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Book your room at Hôtel Central
Twin Room, 2 Single BedsMax Occupancy: 2 guests
Double RoomMax Occupancy: 2 guests
Superior Double RoomMax Occupancy: 2 guests
Superior Twin RoomMax Occupancy: 2 guests
Family RoomMax Occupancy: 4 guests
Superior Family RoomMax Occupancy: 5 guests
SuiteMax Occupancy: 3 guests
Single RoomMax Occupancy: 1 guest
Standard Double RoomMax Occupancy: 2 guests
Get an overview of this hotel3-star hotel with restaurant and bar/lounge
Located in the heart of Beaune, this hotel is steps from Hotel Dieu, Marche Aux Vins Winery, and Burgundy Wine Museum. Collegiate Church of Notre-Dame and Maison Alex Gambal Winery are also within 10 minutes.
Hotel Features
This smoke-free hotel features a restaurant, a bar/lounge, and valet parking. WiFi in public areas is free. Additionally, free newspapers, tour/ticket assistance, and multilingual staff are onsite.
Room Amenities
All 20 rooms offer free WiFi, flat-screen TVs with digital channels, and hair dryers. Guests will also find desks and free toiletries.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. High-speed wireless Internet access is complimentary. This Beaune hotel also offers tour/ticket assistance, multilingual staff, and complimentary newspapers in the lobby. Onsite parking is available (surcharge).
Hôtel Central is a smoke-free property.
- Babysitting or childcare (surcharge)
- Total number of rooms - 20
- Number of floors - 2
- Bar/lounge
- Breakfast available (surcharge)
- Free newspapers in lobby
- Front desk (limited hours)
- Tours/ticket assistance
- Free WiFi
- Multilingual staff
- Valet parking (surcharge)
- Restaurant
- Year Built 1595
- Free parking nearby
- Smoke-free property
- Number of buildings/towers - 1
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Valet parking (surcharge), Free parking nearby
Room Amenities
- Free toiletries
- Hair dryer
- Desk
- Digital TV service
- Flat-panel TV
- Free WiFi
Where to Eat
Buffet breakfasts are available for a surcharge and are served each morning between 7:30 AM and 9:30 AM.
Le Cheval Blanc - This restaurant specializes in French cuisine and serves breakfast, lunch, and dinner. Guests can order drinks at the bar and enjoy alfresco dining (weather permitting). Open select days.
Hotel Policies
Check-in time starts at 3 PM
Check-in time ends at 9:00 PM
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
Pets allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Resort fee: EUR 1 per person, per night
- Fee for buffet breakfast: EUR 10,50 for adults and EUR 5 for children (approximately)
- Valet parking fee: EUR 20 per night
National Rating
This hotel has received its official star rating from the French Tourism Development Agency, ATOUT France.


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Javanese Beef
21 Mar 2011
|Vegetable oil
|2 Cup (32 tbs) (For Deep Frying)
|Chuck steak
|1 1⁄2 Pound, cut into 3/4 in cubes (750 Gram)
|1 Large, chopped
|3 Clove (15 gm), crushed
|Kechap manis
|4 Fluid Ounce (1/2 Cup, 125 Milliliter)
|Chili paste
|2 Teaspoon (Sambal Oelek)
|Coconut milk
|8 Fluid Ounce (1 Cup, 250 Milliliter)
|Lime juice
|1 Tablespoon
|Coconut shavings
|2 Tablespoon (Fresh)
1. Heat oil in a large saucepan until a cube of bread dropped in browns in 50 seconds. Add beef and deep-fry for 5 minutes or until brown. Remove beef from oil and drain on absorbent kitchen paper.
2. Heat 1 tablespoon oil in a frying pan over a medium heat, add onion and garlic and stir-fry for 3 minutes or until onion is soft.
3. Stir in kechap manis, chili paste (sambal oelek), coconut milk and lime juice and bring to simmering. Simmer, stirring occasionally, for 15 minutes or until mixture thickens slightly.
4. Return beef to pan and cook for 5 minutes longer or until heated through. Sprinkle with coconut shavings and serve.
Recipe Summary
Difficulty Level:Medium
Course:Main Dish
Dish:Dry Curry
Preparation Time:30 Minutes
Cook Time:30 Minutes
Ready In:60 Minutes
Rate It
0 Comments
Javanese Beef Recipe


text:
This relates to a lens made of donor corneal tissue suitable for use as a contact lens or an implanted lens, to a method of preparing that lens, and to a technique of placing the lens on the eye. The lens is made of donor corneal tissue that is acellularized by removing native epithelium and keratocytes. These cells optionally are replaced with human epithelium and keratocytes to form a lens that has a structural anatomy similar to human cornea. The ocular lens may be used to correct conditions such as astigmatism, myopia, aphakia, and presbyopia.
1. A device for separating a living epithelial tissue region from an eye having an anterior corneal surface and an epithelial tissue layer, the device being configured for lifting from the corneal surface, a substantially continuous, living epithelial layer substantially free from corneal tissue and having at least an edge connected to the corneal surface.
2. The device of
3. The device of
4. The device of
5. A device for separating a living epithelial tissue region from an eye having an anterior corneal surface and an epithelial tissue layer, comprising a device configured for lifting from the corneal surface, a substantially continuous, living epithelial layer substantially free from corneal tissue and having at least an edge connected to the corneal surface, said device further configured to be removed from contact with the corneal surface leaving the living epithelial layer attached.
6. The device of
7. The device of
8. The device of
This is a continuation of pending U.S. patent application Ser. No. 10/243,121, filed Sep. 13, 2002, a continuation of PCT Application No. PCT/US01/22633, having an International Filing Date of Jul. 18, 2001, and a continuation-in-part of pending U.S. patent application Ser. No. 09/618,580, filed Jul. 18, 2000.
This disclosure is in the field of ophthalmology. More particularly, it relates to a device for lifting an epithelial layer from the anterior surface of the cornea. The disclosure includes methods for placement of a lens beneath that epithelial layer.
The visual system allows the eye to focus light rays into meaningful images. The most common problem an ophthalmologist or optometrist will encounter is that of spherical ammetropia, or the formation of an image by the eye which is out of focus with accommodation due to an improperly shaped globe. The ophthalmologist or optometrist determines the refractive status of the eye and corrects the optical error with contact lenses or glasses.
Many procedures have been developed to correct spherical ammetropia by modifying the shape of the cornea. Light entering the eye is first focused by the cornea, which possesses approximately 75% of the eye's overall refractory power. The majority of refractive operations involve either decreasing or increasing the anterior curvature of the cornea.
The procedures in early corneal refractive surgery such as keratophakia and keratomileusis were originally developed to correct myopia and involved removing a corneal disc from the patient with a microkeratome. The removed corneal disc was then frozen prior to reshaping the posterior surface with a cryolathe. After thawing, the disc was returned to the eye and secured with sutures.
Epikeratophakia, as described in U.S. Pat. No. 4,662,881, is a procedure that involves inserting a precut donor corneal tissue lens with beveled edges into corresponding grooves in recipient cornea. The lens is then sutured to the corneal bed. The donor lens is lyophilized and requires rehydration before placement on recipient cornea.
These techniques and their variations were generally considered to be unsuccessful due to frequent complications involving irregular astigmatism, delayed surgical healing, corneal scarring, and instability of the refractive result. The problems were attributed to the technical complexity of the procedures as well as to the distortion in architecture of the corneal tissue secondary to lens manipulation. For example, in epikeratophakia, epithelial irregularity is induced by lyophilization of the donor lens. Freezing of the lenticule in keratophakia and keratomileusis also causes severe damage to epithelial and stromal cells and disrupts the lamellar architecture of the cornea.
Described is a pre-fabricated lens made of donor corneal tissue obtained from tissue sources such as human or animal cornea. The lens is a corneal disc that is preferably shaped on the posterior surface generally to conform in shape to the eye's anterior surface. The lens may be shaped by an ablative laser, e.g., by an excimer laser or other suitable laser. The corneal lenticule is living tissue that has not been frozen, lyophilized, or chemically modified, e.g., fixed with glutaraldehyde to crosslink corneal tissue. Pre-existing keratocytes are removed and then replaced with human keratocytes to decrease antigenicity. After removal of epithelium in the central zone of the recipient's cornea, the lens is placed on this zone in the same manner that a contact lens is placed on the eye.
Ocular lenses found in the prior art do not use native cornea, but are formulated using soluble collagen such as collagen hydrogels, e.g., polyhydroxyethylmethacrylate, or other biocompatible materials. For example, in U.S. Pat. No. 5,213,720, to Civerchia, soluble collagen is gelled and crosslinked to produce an artificial lens. In addition to hydrogels, U.S. Pat. No. 4,715,858, to Lindstrom, discloses lenses made from various polymers, silicone, and cellulose acetate butyrate.
In the cases where ocular lenses use corneal tissue, the lenses are either corneal implants or require a separate agent to adhere the lens to the corneal bed. U.S. Pat. No. 5,171,318, to Gibson et al., and U.S. Pat. No. 5,919,185, to Peyman, relate to a disc of corneal tissue that is partially or entirely embedded in stroma. The ocular lens device disclosed in U.S. Pat. No. 4,646,720, to Peyman et al., and U.S. Pat. No. 5,192,316, to Ting, is attached to recipient cornea with sutures. The corneal inlay described in U.S. Pat. No. 4,676,790, to Kern, is bonded to recipient cornea using sutures, laser welding, or application of a liquid adhesive or crosslinking solution.
The ocular lens device described here does not alter the anatomical structure of corneal tissue. U.S. Pat. No. 4,346,482, to Tennant et al., discloses a "living contact lens" consisting of donor cornea that has been anteriorly curved for correction of vision. However, this lens is frozen prior to reshaping on a lathe which results in stromal keratocyte death. U.S. Pat. No. 4,793,344, to Cumming et al., also describes a donor corneal tissue lens that is modified by treatment with a glutaraldehyde fixative that preserves the tissue and prevents lens swelling. This treatment alters the basic structure of the corneal lenticule by crosslinking the tissue.
Furthermore, the cited documents do not show any methods of lens preparation that remove native corneal tissue cells and replace them with cells cultivated from human cornea. My device is devitalized of native epithelium and keratocytes to create an acellular corneal tissue, and then revitalized with human epithelium and keratocytes. An attempt to construct a so-called "corneal tissue equivalent" was shown in U.S. Pat. No. 5,374,515, to Parenteau et al. However, the collagen used in that "equivalent" is obtained from bovine tendon instead of from cornea. The added keratocytes and epithelium are also not from human sources. The tissue using these cell culturing procedures is also quite fragile.
An excimer laser is used to reform a cornea via the "laser in situ keratomileusis" (LASIK) procedure. In this technique, an excimer laser is used to perform stromal photoablation of a corneal flap or in situ photoablation of the exposed stromal bed. Studies have shown that the inaccuracy of correction by this procedure may be as much as one diopter from the desired value. Lenses (contacts and spectacles), in contrast, are able to correct within 0.25 diopters of the desired value.
U.S. Pat. No. 6,036,683, to Jean et al., shows the use of a laser to reshape the cornea. However, the laser changes the native structure of the cornea by irreversibly coagulating collagen. Post-laser relaxation of collagen is not possible with this treatment.
My described lens, however, in some variations relates to a pre-fabricated donor contact lens that adheres to recipient cornea without sutures. The lens preserves the anatomy of normal corneal tissue. The donor lens may be obtained from human and animal sources, is devitalized of native keratocytes and epithelium to create an acellular tissue, and then optionally revitalized with at least one of human keratocytes and epithelial cells to maintain lens viability and decrease antigenicity. The inventive corneal overlay technique may be completed under local anesthesia as well as general anesthesia, and the availability of a precut lens will greatly decrease procedure time, patient cost, and risk of operative complications. The duration of healing will also be reduced due to the implementation of a lens already repopulated with keratocytes.
None of the cited documents shows or suggest the lens and procedures described herein.
Described is a pre-fabricated ocular lens device having a lens core made of donor corneal tissue from tissue sources such as human or animal cornea. The device may be used as a contact lens or as an implanted lens and may have a generally convex anterior surface and, optionally, a concave posterior surface. The stroma portion of the lens core may be repopulated with replaced keratocytes and the anterior surface is preferably covered with a replaced epithelium. The lens core adheres to recipient cornea without sutures or other adhering materials.
The lens core may be variously used to correct astigmatism, myopia, aphakia, and presbyopia. The lens core may be made of transgenic or xenogenic corneal tissue. Properly treated, the inventive lens may have a clarity at least 85% of that of human corneal tissue of a corresponding thickness. The lens core is not frozen, lyophilized, or chemically treated with a fixative. However, variations of the device may contain therapeutic agents, growth factors, or immunosuppressive agents.
Another component is a method for preparing the lens device. After sharp dissection of a lenticule from donor corneal tissue, the posterior surface is shaped using an ablative laser, such as an excimer laser or other suitable shaping lasers. Native epithelium and keratocytes are removed and then replaced, as desired, with human epithelium and keratocytes.
Also described is a method of corneal overlay that involves de-epithelialization of a portion of the anterior surface of the recipient cornea and placement of the inventive ocular lens device upon that anterior surface. Another method involves the temporary separation of the epithelial tissue by suction or other procedures and placement of a lens beneath that epithelial tissue.
The eye is designed to focus light onto specialized receptors in the retina that turn quanta of light energy into nerve action potentials. As shown in
The cornea (100) is the portion of the corneo-scleral layer enclosing the anterior one-sixth of the eye. The smooth curvature of the cornea is the major focusing power of images on the retina (104) and it provides much of the eye's 60 diopters of converging power. The cornea is an avascular structure and is sustained by diffusion of nutrients and oxygen from the aqueous humor (106). Some oxygen is also derived from the external environment. The avascular nature of the cornea decreases the immunogenicity of the tissue, increasing the success rate of corneal transplants.
The cornea consists of five layers. The outer surface is lined by stratified squamous epithelium which is about five cells thick. Failure of epithelialization results in necrosis of the stromal cap and potential scarring of recipient cornea. The epithelium is supported by a specialized basement membrane known as Bowman's membrane, which gives the cornea a smooth optical surface. The bulk of the cornea, the substantia propria (stroma), consists of a highly regular form of dense collagenous connective tissue forming thin lamellae. Between the lamellae are spindle-shaped keratocytes which can be stimulated to synthesize components of the connective tissue. The inner surface of the cornea is lined by a layer of flattened endothelial cells which are supported by Descemet's membrane, a very thick elastic basement membrane.
As previously mentioned, the focusing power of the cornea is primarily dependent on the radius of curvature of its external surface. In myopia, as seen in
In a first variation of the described lens, the physical shape generally is of a size and configuration that upon installation on the cornea, supplements the curvature of the cornea to correct abnormal conditions such as astigmatism, myopia, hyperopia, presbyopia, and aphakia. Other variations of the lens may be shaped to be placed beneath the anterior surface of the host cornea or to serve as a source of medication.
Typically, the lens core may comprise or consist essentially of acellular donor corneal tissue that has been devitalized, e.g., treated to remove native keratocytes and epithelium, to lessen the chances of tissue rejection and then at least partially revitalized, e.g., treated to introduce at least one of human keratocytes and an epithelial layer, to allow and to support continued use of the inventive lens in place on the eye. The epithelial cells may (often in the form of a discrete layer) be placed on at least a portion of the anterior surface of a lens. In some variations, all of the anterior surface will be so-covered. In one variation discussed below, an epithelial layer will extend beyond the periphery of the lens core and optionally the lens be carried in a biodegradable carrier that is used during placement in the eye and later disappears.
The described lens may be placed on a host eye from which at least a major portion of the native epithelium on that cornea, has been removed. Preferably in this variation, substantially all of the epithelium has been removed from the region upon which the inventive lens will be sited. The lens may also be placed beneath a layer of epithelium lifted from the eye surface during the procedure of introducing the lens onto the anterior surface of the host cornea or in other instances beneath the surface of the host cornea. The described lens may be used variously to correct refraction (because of its shape) or it may be used simply to provide a source of infused medication to the eye.
The donor lenticule or lens core may be obtained from other human (allogeneic) or foreign tissue (xenogenic) sources. Appropriate xenogenic sources include rabbit, bovine, porcine, or guinea pig corneal tissue. The ocular lens cores may also come from transgenic corneal tissue or corneal tissue grown in vitro. In many instances, it is desired that the architecture of the corneal layers in the donated tissue, the normal corneal tissue matrix, e.g., the connective tissue or the stroma, be substantially preserved. The "corneal tissue matrix" is made up of thin layers of collagen fibrils. The term "donor corneal tissue", as used here, is meant to include donor or harvested corneas or corneal tissue containing the "corneal tissue matrix". Additionally, in most variations, it is highly desirable to preserve the anterior surface of the donated corneal tissue as found beneath the native epithelium. The donor corneal tissue is not to undergo harsh treatments such as lyophilization, freezing, or other chemical fixation. Nevertheless, it is sometimes desirable to utilize only a portion of the anterior surface of the donor lens, e.g., in those instances where the inventive lens structure is annular in shape.
The described ocular lens device desirably includes Bowman's membrane, where the donor tissue includes it, to maintain the native structure of human epithelium. Again, it is highly desirable to harvest from donor sources in such a way that the native anterior surface below the epithelium is preserved. I have found that these native structures have a superior ability, particularly after the revitalization steps discussed below, to support and to maintain the replaced epithelium also discussed below. The clarity of the inventive tissue lens core handled in such a way generally will be at least 85%, preferably between 75%-100%, and most preferably at least 90%, of that of human corneal tissue of corresponding thickness.
The overall diameter of my lens is functionally appropriate to perform the desired correction, and generally is less than about 25 mm and more preferably is between 10 and 15 mm. The thickness of the resulting lens is, again, functionally appropriate to perform the desired correction, e.g., generally less than 300 μm, more preferably between 5-100 μm.
As shown in
As shown in
The annular ring (332) may be situated on the lens core either by placement of a suitable dye, i.e., by "tattooing", or by placement of a substantially opaque biocompatible member of, e.g., Dacron mesh or the like, on the posterior surface to filter light rays. Other placements of the annular ring (332) may be envisioned, e.g., on the anterior surface of the inventive lens. The annular ring (332) itself preferably is quite opaque, e.g., passing less than about 80% of incident visible light, but may be chosen in such a way to be less opaque or to correct other maladies such as colorblindness by shifting an incident color into a visible range by color refraction or the like.
As is shown in
The carrier (354), as shown in
The combination (356) of carrier (354), epithelial layer (352)—whether the epithelial layer (352) extends beyond the periphery of the core lens (348) or not, e.g., the epithelial layer (352) is situated only on some or all of the core lens (348)—and core lens (348) placed on that epithelial layer (352), as shown in
When the carrier is used for placement in the eye, the carrier (354) preferably comprises a material meeting two related criteria. First, the material desirably is one that dissolves, erodes, or otherwise shortly clears from the eye to be treated after the combination (356) of the carrier (354), epithelial layer (352), and the donor lens (348) are introduced to that eye. Preferably also, the carrier is of a material that serves as a substrate for a pre-grown epithelial layer. Most desirably, the carrier (354) satisfies both criteria. The carrier (354) may comprise a material such as collagen, gelatin, starch, glucosamine glucans, proteins, carbohydrates, polyanhydrides such as polylactides and polyglycolides, their mixtures and copolymers, polydiaxanone, etc.
The carrier (354) may also be infused with medication or other treatment material, antiangiogenesis materials or the like.
Returning to
Although the order of the process steps outlined below is typical, it should be understood that such steps may be varied as needed to produce the desired result.
Generally, the lens will first be shaped to an appropriate shape as discussed above. The lens core may then be subjected to processes of sterilization, devitalization, and revitalization. Removal of epithelium (de-epithelialization) and keratocytes (acellularization) from the donor lens will be referred to as "devitalization". The addition of human epithelium and keratocytes will be referred to as "revitalization". One desirable method for accomplishing those steps is found just below. Other equivalent methods are known.
Phosphate buffered saline (PBS) with antibiotics, epithelial cell media, and keratocyte media are solutions used during these processes. The "PBS with antibiotics" solution may contain:
PBS with Antibiotics
The composition of the epithelial cell media may include:
Epithelial Cell Media
The composition of the keratocyte media may include:
After harvesting the lens core from donor corneal tissue and following the shaping step, the lens may be sterilized, for instance, by immersion into 98% glycerol at room temperature. Three weeks of glycerol treatment inactivates intracellular viruses and any bacteria or fungi. Ethylene oxide gas sterilization may also be used, but tends to induce variable damage to stromal tissue.
I prefer to de-epithelialize the donor lens by placing it in a one molar solution of salt (preferably sodium chloride) at a temperature from 4 to 25� C. After four to eight hours of incubation, the entire epithelial layer generally will split from the corneal stroma and may be easily removed. Thereafter the lens may be washed in a PBS solution with antibiotics to remove salt and cellular material.
Another method of removing the epithelium is via the use of vacuum. The epithelium may be split from the stroma by means of suction (−100 mm Hg to −450 mm Hg). After fifteen minute to 1 hour, the epithelium typically will separate from the stroma at the basement membrane layer. Thereafter the lens may be washed in a PBS solution with antibiotics to remove salt and cellular material.
Finally, the donor lens may be de-epithelialized by placing it in sterile PBS with antibiotics for four hours and changing the solution many times. The lens core may then be kept submerged in the PBS solution at 37� C. for one week to produce a split between the epithelium and the stroma. The epithelium may then be removed, e.g., by physically scraping or washing with a liquid stream. Small numbers of lenses may be stripped of epithelium by gentle scraping with forceps.
The de-epithelialized lens may be then immersed in a solution of detergent (for example 0.025% to 15% sodium dodecyl sulfate) to wash out the keratocyte cellular material. A detergent will solubilize and wash out the keratinocytic material. This can take place from 1 to 8 hours. Afterward the cellular material can be washed in a buffered solution with antibiotics to remove detergent and cellular material.
Alternatively, the de-epithelialized lens may be immersed in sterile PBS with antibiotics for an appropriate period, e.g., several weeks, perhaps six weeks to remove native keratocytes. The solution may be changed twice weekly. In some instances, it may not be necessary to remove keratocytes from the donor lens, e.g., when the donor tissue is obtained from a transgenic source and has minimal antigenicity.
Preparation of Cells
Human epithelial cells and keratocytes are used in the revitalization process. Epithelial cells may be obtained from a tissue bank, but are preferably obtained from fetal or neonatal tissue. Fetal cells are most preferable, since the properties of fetal tissue minimize scarring during any wound healing process.
In any event, freshly isolated epithelial cells, obtained by trypsinization of corneal tissue, may be seeded onto a precoated feeder layer of lethally irradiated 3T3 fibroblasts (i.3T3) in epithelial cell media. Cells are cultured and media changed every three days until the cells are 80% confluent, about 7-9 days. Residual i.3T3 are removed with 0.02% EDTA (Sigma-Aldrich) before the epithelial cells are detached using trypsin (ICN Biomedicals). Another method of regenerating epithelium involves culturing autologous epithelial cells on human amniotic membrane as described in Tsai et al. (2000). "Reconstruction of Damaged Corneas by Transplantation of Autologous Limbal Epithelial Cells," New England Journal of Medicine 343:86-93.
Keratocytes may be extracted from the remaining stromal tissue. The stroma is washed in PBS, finely minced, and placed in 0.5% collagenase A (ICN Biomedicals) at 37� C. for 16 hours. Keratocytes obtained from this enzyme digest are then serially cultured in keratocyte media. The epithelial cells and keratocytes generated in the revitalization step will be referred to as "replaced" epithelial cells and keratocytes.
The acellular donor lens core may then be placed on a hydrophilic, polyelectrolyte gel for completion of the re-vitalization. The preferred polyelectrolytes are chondroitin sulfate, hyaluronic acid, and polyacrylamide. Most preferred is polyacrylic acid. The lens is immersed in keratocyte media and incubated with approximately 3�105 keratocytes for 48 hours at 37� C. Approximately the same amount of epithelial cells are then added to the anterior stromal surface. Tissue culture incubation continues for another 48 hours. Keratocyte media is changed every two to three days. Once the epithelium is regenerated, the polyelectrolyte gel draws water out of the lens at a pressure of about 20-30 mm Hg until the original lens dimensions are obtained.
Replaced epithelium covers at least a portion of the anterior surface of this variation of the inventive lens and replaced keratocytes repopulate the stroma of the lens core after revitalization.
As noted above, another variation of the lens includes an epithelial layer (352 in
It may be beneficial in some instances also to incorporate therapeutic agents, growth factors, or immunosuppressive agents into the lens core further to decrease the risk of rejection or remedy disease states.
One procedure for applying the lens of this invention is depicted in
Another placement procedure variation is shown in
It is also within the scope of the description to use the preparation procedure for the LASEK procedure for the step of exposing the corneal surface for application of the lens. The LASEK procedure is known and, unlike the LASIK procedure, does not involve temporary removal of an anterior flap of corneal tissue with a surgical tool but rather only utilizes an ethanol wash and a temporary withdrawal of the epithelial layer for a laser treatment. Such a preliminary step, the washing with ethanol to perturb the junction between the corneal stroma and the epithelium is adequate to provide a layer of epithelium for temporary movement and insertion of the inventive lens on the corneal surface.
I have described the structural and physiologic properties and benefits of this donor ocular lens. This manner of description should not, however, be taken as limiting the scope of the disclosure in any way.
Referenced by
Original Image


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Semper International
This week Julie Greenbaum highlights industry news, including a major announcement from the Postal Regulatory Commission, along with other major announcements from Webcrafters, Carly Fiorina, former CEO of HP, Vision Integrated Graphics and Tobe Direct, RR Donnelley, Cenveo, HP, Canon Solutions America, and Semper International.
Semper's Second Quarter 2015 Industry Insight Survey Report was created in partnership with Printing Impressions.
Printing Impressions has teamed up with Semper International to execute Semper's quarterly survey on printing industry insights.
This week Julie Greenbaum highlights industry news, including Printing Impressions coverage from Canon Solutions America's East Coast Inkjet Insider Summit in Hartford, CT, that featured a tour of Data-Mail's full-service direct mail printing and lettershop facility. Other major announcements this week came from Presstek, 4over Inc., Printing Industries of New England (PINE), U.S. Government Publishing Office (GPO), RR Donnelley, HP, Kodak, Alliance Franchise Brands, Semper International, Wilen Direct, TPC Printing and Packaging and KBA, Hadley Printing and Komori.
Rick Littrell has been hired as the new vice president of Direct Hires, TechCreative at Semper International.
David Regan is president of Semper International, a Boston-based job placement firm that specializes in the graphic arts industry. He discusses the latest, highly positive state of the industry based on Semper's quarterly Industry Insights survey, as well as the current job market for skilled and temporary labor in the printing industry. Regan notes how hard it is for employers to fill various skilled positions within various regions of the United States.
This week Julie Greenbaum highlights major industry newsmakers, including Pictorial Offset, RR Donnelley, Sterling Publishing, EFI, Konica Minolta Business Solutions, The Harman Press, Semper International, Canon Solutions America, Inca Digital Printers and Imperial Communications.
The current survey from Semper International reports the third straight quarter of profits for more than 80 percent of respondents. This reveals continued growth and optimism in the print and graphics industry. Since February 2003, Semper International has provided a quarterly survey offering estimates of trends in the printing and graphics industries.
Several straight quarters of positive signals have finally blossomed, and Semper's First Quarter data reveals that the industry is back in bloom. Coming into 2015, its company respondents reported record-setting profitability of 85 percent and sustained sales growth for five straight quarters. In addition, one-third of firms reported new sales growth in the first two weeks of 2015.
Heading into the fourth quarter, Semper International, a placement firm for skilled help in the graphic arts and printing industry, reported stunning improvements amid some market unrest. As the report stated, "In the 12 years we have been conducting our survey, we have never before seen ZERO respondents reducing staff."


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Join The Conversation
Mar 5 Posted 2 years ago
I am a fan of DevHope.com, yeah i know it sound strange to you, but I bet you they have got a model that seems to be taking over the Social media market! they are not just into juicing up your day with the best, of what you are searching for? but they also, tell you that it's possible for you to do that to others on their platform.
Mar 4 Posted 2 years ago
Anna - I'm a big fan of moo.com products and services all around. It helps that the company's marketing is witty, relevant and personal. Will have to take a deeper dive into the Moo social presence. Thanks for sharing!
Mar 4 Posted 2 years ago
I've always been very fond of what moo.com is doing on social media. Since the very first email that Little Moo, their print robot, sent to me - I'm hooked! Moo tells their story so cute! (I've written about it here).
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11 April 2015 - 02:53 PM
1) Ultralight Digital Single Tray ($40): These components show wear (see photos)
27 March 2015 - 08:18 AM
Like the title says. I'm looking for the Aquatica 18480 8" dome shade.
27 March 2015 - 08:07 AM
Just as the title says, looking for Aquatica part number 18712.1 for the 105mm VR.
Note that the .1 is the hard plastic version of the focus gear, not the earlier soft rubber version.
16 March 2015 - 01:11 PM
Title says it all.
Likely a long shot but figured I would ask.
09 March 2015 - 01:09 PM
I have two Aquatica extension rings for sale.
Both come from a recently purchased kit and I don't need them.
The 18453 is brand new without a single scratch on it. It's a 28.5mm extension ring most commonly used with the Nikon 105mm and Tokina 10-17 with 1.4x teleconverter, 12-24mm, etc. No idea how they'd be used on Canon rigs so take a look at the charts for more info.
The 18457 extension is used and is in good functional shape. It looks like the previous owner used it with the Nikon 17-35mm, not sure of other uses.
Selling to fund the purchase of Aquatica port extension 18463 (21.5mm). So, in the off chance someone should have one to sell or trade, I'd certainly be interested.
New 18453: $150
Used 18457: $150 (50% retail)
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Original recipe yields 8 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Ready In
I haven't tried this as of yet, but I know it will be wonderful I can smell it cooking already. Thanks for the recipe..
Stew is always a 'whatever I have' mosh pot in my kitchen. With that said I am rating this with a few substitutes but really do not think it changes the outcome except for minor personal tastes...
Wonderful recipe! It was a huge hit. I added 6 garlic cloves, 1 TBS pickling spice & homemade beef broth.


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An ideal location! Sheraton Essen Hotel is located in the heart of Essen, with a direct connection to the Philharmonie and within walking distance of central station, business center and shopping area. From here, Essen Fair and Grugahalle can easily be reached. Dusseldorf International Airport is also only a 20-minute ride away.
Not only is the location excellent. Relax after a hard day in your Sheraton Sweet Sleeper bed or enjoy a superb dinner in the Restaurant am Park. In fine weather you can also enjoy you dinner at the summer terrace with an enchanting view into the park. The destination Essen also has a lot to offer for your weekend getaway, including the Zeche Zollverein and many family activities.
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text: 'Shop Talk': It's All About Education September 24, 2010 As part of Tell Me More's month-long back-to-school focus on education, host Michel Martin talks education with the guys in the barbershop. Included in the discussion are the movie "Waiting for Superman," and the travails of embattled DC Public Schools Chancellor Michelle Rhee, and the angry dad who faced down his daughter's bullies. Joining the conversation are Jimi Izrael, a freelance journalist and Presidential Fellow at Case Western Reserve University; Lester Spence, a professor of Political Science at Johns Hopkins University and home schooled his children; Claudio Sanchez, NPR's education correspondent and former schoolteacher; and Jay Mathews, education columnist for The Washington Post. Listen Loading… 17:50 Playlist Download Embed Embed Close embed modal <iframe src="http://www.npr.org/player/embed/130104128/130103127" width="100%" height="290" frameborder="0" scrolling="no">


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IT'S NOT THE GUNS, stupid.
At least, it's not the Glock, Sig Sauer and Bushmaster semi-automatic rifle that a 20-year-old monster brought with him to slaughter 20 young children and their teachers last Friday.
It's the 270 million guns that are sitting in houses and gun safes, in rifle racks and glove compartments all over this nation. It's the culture of guns - nine guns for every 10 Americans - that we must confront. How can we lead the world in per-capita gun ownership and still be surprised that Friday's tragedy happened, and that it happened last week in Oregon, and months ago at a movie theater, and could continue to happen over and over and over again?


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How did three Danes end up being tortured in Lebanon?
The human cost of the Greek financial crisis
01 Mar 2011 01:19 GMT | Politics, Africa, US & Canada, Canada, Egypt
Hillary Clinton, the US secretary of state, has said the government of Muammar Gaddafi must be held to account over atrocities committed in Libya as she reiterated calls for the leader to step down.
Speaking at the UN Human Rights Council in Geneva, Switzerland, on Monday, Clinton said Gaddafi must leave power "now, without further violence or delay"."Gaddafi and those around him must be held accountable for these acts, which violate international legal obligations and common decency," she said.
"We have seen Colonel Gaddafi's security forces open fire on peaceful protesters. They have used heavy weapons on unarmed civilians. Mercenaries and thugs have been turned loose to attack demonstrators."Clinton said Washington was keeping "all options on the table" in terms of action against the government, and that a no-fly zone was "an option we are actively considering".
Meanwhile, the US ambassador to the United Nations Susan Rice said Washington is in talks with its NATO partners and other allies about military options for dealing with Libya.
A Pentagon official said the US military was repositioning naval and air forces around Libya.
"We have planners working and various contingency plans and I think it's safe to say as part of that we're repositioningforces to be able to provide for that flexibility once decisions are made ... to be able to provide options and flexibility," Colonel David Lapan, a Pentagon spokesman, said.
Calls for no-fly zone
Al Jazeera's Hoda Abdel-Hamid, reporting from the eastern city of Benghazi, where the opposition is in control, said people there were opposing any possible foreign military invention but would welcome a no-fly zone.
"They say that would diminish the ability of the regime to bring in mercenaries from Africa, those mercenaries that the opposition accuse of fighting alongside government forces," she said.
"Also, they say a no-fly zone will safeguard the opposition in the sense that it would prevent any kind of aerial bombardment. That's one thing people here are very scared of."
Clinton's comments came after the European Union approved its own sanctions including an arms embargo and travel bans against Libya."We are already working on EU restrictive measures that should come into force quickly," Catherine Ashton, the bloc's foreign policy chief, said at the UN human rights meeting."Together with that we will adopt additional accompanying measures such as an embargo on equipment which might be used for internal repression and we're looking at individuals under the travel restrictions and the assets freeze."
The 27-nation bloc has agreed to freeze the assets of Gaddafi, his family and government, and ban the sale of goods such as tear gas and anti-riot equipment.It is believed the EU sanctions are aimed at strengthening a raft of measures passed by the United Nations Security Council on Saturday, which include referring Libya to the International Criminal Court (ICC) over the brutal crackdown on pro-democracy protesters.Luis Moreno-Ocampo, the prosecutor of the ICC, said a preliminary investigation into possible crimes against humanity committed in Libya would begin on Monday.
"There will be no impunity for leaders involved in the commission of crimes," he said.He said he would decide within a few days whether or not to launch a full investigation of alleged crimes committed since February 15, that would enable prosecutors to collect evidence and request an arrest warrant against those identified as responsible.A growing number of world leaders are placing pressure on Gaddafi to step down amid a violent uprising. On Sunday Britain and Canada followed moves by the US to freeze the assets of Gaddafi and his family, while on Monday Germany said it is proposing to freeze all financial payments to Libya for 60-days.'Exile is an option' Navi Pillay, the UN human rights chief, told the conference that the international community must support reforms in the Middle East in "words and deeds"."The council should not relax its vigilance over Libya as the threat of violent reprisals against civilians still looms," she said.
"Although we have not seen credible independent evidence that Gaddafi has used jets to attack the protesters, that doesn't mean that he will not."
Ibrahim Sharquieh, Brookings Doha Centre
The moves come amid growing outrage over the bloodshed in Libya, blamed on forces loyal to Gaddafi. The embattled leader remains defiant despite the opposition gaining ground across the country, and has vowed to purge the country of protesters "city by city, house by house".
The US is pressing Europe for tough sanctions on the Libyan government to turn up the heat on Gaddafi, saying that sanctions would convince the leader's remaining loyalists to abandon his regime.
"The US has a wider sanctions regime than the UN has decided and they would like the Europeans to step in on that," Al Jazeera's Nick Spicer, reporting from Geneva, said.
Speaking in Cairo, John McCain and Joe Lieberman, two leading US senators, called for the immediate imposition of a no-fly zone over Libya.
They also urged the White House to recognise the "provisional government" set up by Gaddafi opponents in the eastern city of Benghazi.
Speaking to Al Jazeera, Ibrahim Sharquieh, the deputy director of the Brookings Doha Centre, said that a "no-fly zone is certainly a good idea".
"Although we have not seen credible independent evidence that Gaddafi has used jets to attack the protesters, that doesn't mean that he will not."David Cameron, the British prime minister, said the UK is working with its allies on a plan to establish a military no-fly zone over Libya, a move also mentioned by Jay Carney, a White House spokesman.Carney added that Gaddafi could go into exile to help satisfy demands by the US for him to step down."Exile is certainly one option for him to affect that change," he said on Monday.
Source: Al Jazeera and agencies
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