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Conceived and designed the experiments: RL JK WS BK. Performed the experiments: SE MO AM. Analyzed the data: SE EEM WE. Contributed reagents/materials/analysis tools: RL JK BP. Wrote the paper: SE EEM BK. Provided technical support: JAM.
Because mitochondria play an essential role in energy metabolism, generation of reactive oxygen species (ROS), and apoptosis, sequence variation in the mitochondrial genome has been postulated to be a contributing factor to the etiology of multifactorial age-related diseases, including cancer. The aim of the present study was to compare the frequencies of mitochondrial DNA (mtDNA) haplogroups as well as control region (CR) polymorphisms of patients with malignant melanoma (n=351) versus those of healthy controls (n=1598) in Middle Europe.
Using primer extension analysis and DNA sequencing, we identified all nine major European mitochondrial haplogroups and known CR polymorphisms. The frequencies of the major mitochondrial haplogroups did not differ significantly between patients and control subjects, whereas the frequencies of the one another linked CR polymorphisms A16183C, T16189C, C16192T, C16270T and T195C were significantly higher in patients with melanoma compared to the controls. Regarding clinical characteristics of the patient cohort, none of the nine major European haplogroups was associated with either Breslow thickness or distant metastasis. The CR polymorphisms A302CC-insertion and T310C-insertion were significantly associated with mean Breslow thickness, whereas the CR polymorphism T16519C was associated with metastasis.
Our results suggest that mtDNA variations could be involved in melanoma etiology and pathogenesis, although the functional consequence of CR polymorphisms remains to be elucidated.
Malignant melanoma is one of the most aggressive skin cancers arising from the pigment-producing cells called melanocytes. Due to the fact that its worldwide incidence in Caucasian populations has been rising steadily for several decades [1], malignant melanoma has become an important public health issue and its early detection remains vital to lowering mortality [2]. As in many other malignancies, both genetic predisposition and environmental risk factors such as UV radiation are involved in melanoma development [1].
Mitochondria play an essential role in energy metabolism, initiation of apoptosis and generation of reactive oxygen species (ROS). Therefore, it has long been postulated that variation of mitochondrial functions may contribute to the development and progression of cancer [3].
Mitochondria possess their own DNA (mtDNA), a circular double-stranded molecule consisting of 16,569 base pairs coding for 37 genes: 13 protein subunits of the electron transport chain, 22 tRNAs and 2 rRNAs. In addition, mtDNA contains a non-coding control region (CR), also called the D-loop, with regulatory sequences controlling mtDNA replication and transcription [4]. The mutation rate of mtDNA is approximately 10-fold higher than that of nuclear DNA. This is due to the absence of protecting histones and the lack of an efficient DNA repair system in mitochondria. Furthermore, the respiratory chain is a potent source of free radicals, which additionally can lead to DNA damage [3], [5]. It has been hypothesized that mtDNA mutations or inherited polymorphisms may alter the encoded protein subunits of the respiratory chain complexes. This in turn could result in altered ROS production, precipitating a cascade of events, including elevated levels of mtDNA mutation, impairment of respiratory chain activity, and further ROS generation, thus setting in motion a vicious circle of oxidative stress, which may be involved in the formation and progression of tumors [6], [7], [8].
Somatic mtDNA mutations have been found in several malignancies, including breast, ovarian, endometrial, prostate, colorectal, gastric, thyroid, renal, hepatocellular, esophageal, pancreatic and brain tumors [3], [5], [9]–[12]. In particular, the D-loop region (nucleotides 16024–516) has been shown to be a mutational hot spot in human malignancies [13], [14]. There is strong evidence that genetic instability in the D-loop region may be involved in carcinogenesis of human cancers, possibly by affecting copy number and gene expression of the mitochondrial genome [15].
Mithani et al. reported finding somatic mitochondrial mutations in melanoma specimens and melanoma cell lines, with an incidence of 75% [16]; the incidence of mutations within the D-loop region was considerably higher than for the remainder of the mitochondrial genome. Another study detected somatic mitochondrial mutations in 45% of melanoma cell lines and 42% of melanoma specimens [17]. Somatic alterations within the polycytidine (poly-C) tract (nucleotides 303–315) of the D-loop region were detected in 30% of melanoma cell lines and in 17% of melanomas. Deichmann et al. found several alterations of the mitochondrial D-loop in primary melanoma tumors; the overall frequency was 12% [18]. This is in line with another melanoma study, which detected an overall frequency of D-loop alterations of 13% [19].
Investigation of somatic mitochondrial mutations in cancer is one approach to assess the contribution of mtDNA variation to melanoma development and progression. The other approach is to examine disease-associated mtDNA haplotypes and single-nucleotide polymorphisms (SNPs). There is evidence that "neutral" germ-line mtDNA polymorphisms may be risk factors for age-related multifactorial diseases, including cancer, and that they may influence disease outcome [20], [21]. Association with mitochondrial haplogroups has been discussed for prostate and renal cancer [22], breast [21], [23], thyroid [24], esophageal [25], endometrial [26] and colorectal cancer [27].
The aim of the present study was to compare the frequencies of mtDNA haplogroups and CR polymorphisms of patients with malignant melanoma to those of healthy controls in Middle Europe.
The nine major European mtDNA haplogroups and CR polymorphisms were analyzed in whole blood samples of 351 patients with malignant melanoma and compared to 1598 control subjects [28]. Clinical characteristics of the patients and controls are shown in Table 1.
The frequencies of the major European mitochondrial haplogroups did not differ significantly between patients with melanoma and control subjects (Table 2). Only the frequency of haplogroup K was significantly lower in patients with malignant melanoma (p=0.043), but the difference did not remain statistically significant after adjustment for sex and age (p=0.129).
The second part of our study focused on CR polymorphisms. MtDNA was analyzed between nucleotide positions (np) 16024 and 526 in all 351 melanoma patients, and 211 homoplasmic polymorphisms were found (Table S1). Among these polymorphisms, we detected 196 single base-pair exchanges, seven single base-pair deletions and two single base-pair insertions, compared to the revised Cambridge Reference Sequence. At position 302 we found CC-insertions, and at position 310 TC-insertions in addition to C-insertions. A CA-deletion at positions 514 and 515 occurred 24 times. CA-insertions, CACA-insertions and CACACA-insertions at this site were observed 23 times. Of the 211 polymorphisms detected, 13 are not listed in MITOMAP or the Human Mitochondrial Genome Database (www.mitomap.org; www.genpat.uu.se/mtDB/). Twenty-six of the 211 CR polymorphisms were detected at a frequency ≥5% in either the melanoma or the control group [29] (Table 3). These were subjected to further statistical analysis. Five of them, A16183C, T16189C, C16192T, C16270T and T195C, were highly linked to one another and found to have a significantly higher frequency in patients with melanoma compared to the control cohort (p<0.05) (Table 3). These differences remained significant after adjustment for sex and age.
To determine whether haplogroups or CR polymorphisms within the melanoma cohort were associated with tumor invasiveness or disease progression, we also analyzed the frequencies of mtDNA haplogroups and CR polymorphisms in relation to Breslow thickness of the tumor and metastasis.
The vertical depth of the melanoma (measured downward from the top of the stratum granulosum of the epidermis) has been shown to be the factor that best correlates with prognosis [2]. Several studies showed that Breslow thickness is associated with male gender [30], [31]. This finding was confirmed by our study. Males (n=158) had a mean Breslow thickness of the tumor of 1.98 mm (SD 2.137) whereas females (n=170) showed a mean of 1.50 mm (SD 1.521) (p=0.032).
Logarithmized data of Breslow thickness were analyzed using a two-sample unpaired t-test. None of the nine major European haplogroups was found to be associated with Breslow thickness of melanoma (data not shown). When subdividing melanoma cases into categories for comparison of less invasive and thick melanoma (category 1: Breslow thickness ≤4.00 mm, n=296; category 2 Breslow thickness >4.00 mm, n=32), haplogroup J was overrepresented among thick melanomas (21.9% versus 9.1%; p=0.034) (Figure 1). This trend of higher incidence of haplogroup J within Breslow category 2 was very similar in both sexes (data not shown). In addition, the incidence of haplogroup H rose from 40.5% (category 1) up to 53.1% (category 2) but did not reach statistical significance.
When analyzing CR polymorphisms and logarithmized data of Breslow thickness using a two-sample unpaired t-test, two polymorphisms reached statistical significance. These two variants, namely a CC-insertion at position 302 and a C-insertion at position 310, are both located within a homopolymeric C-stretch between np 303 and 315 interrupted by a thymine at position 310. This poly-C stretch is situated in the second hypervariable region (HVR II) and was reported to be a mutational hotspot [32]. Subjects harboring the A302CC-insertion (n=41) showed a geometric mean Breslow thickness of 1.55 mm, whereas patients without this alteration (n=287) had a geometric mean Breslow thickness of 1.07 mm (p=0.008). In contrast, the T310C-insertion was associated with lower geometric mean Breslow thickess (1.10 mm versus 3.06 mm; p=0.015). These two polymorphisms also reached significance when compared within the two Breslow category groups: 28.1% of patients in category 2 had the A302CC-insertion compared to 10.8% in category 1 (p=0.002). The frequency of the T310C-insertion was 99.0% in category 1 versus 90.6% in category 2 (p=0.020). In addition, the frequency of an A to G transition at np 73 decreased from 56.1% in Breslow category 1 to 37.5% in category 2 (p=0.028) (Table 4).
Analyses of mitochondrial haplogroups and metastasis did not reveal an association between specific haplogroups and tumor invasiveness. Concerning CR polymorphisms, the T16519C substitution was found in 48.5% of patients with metastases, compared to 34.4% without metastases (p=0.026).
Because mitochondria play a central role in energy and ROS production, mtDNA is an obvious candidate for genetic susceptibility studies in cancer. In the present study, for the first time, frequencies of mtDNA haplogroups and CR polymorphisms were determined in patients with malignant melanoma. No significant difference between haplogroup frequencies of patients with melanoma and control subjects could be found. Analysis of clinical characteristics revealed that there is also no association between mtDNA haplogroups and tumor invasiveness or metastatic progression. Only when categorizing Breslow thickness did we find an association: haplogroup J was overrepresented in thick melanoma, indicating that this haplogroup might be associated with higher tumor thickness and therefore less favorable prognosis [2], [33]. However, this finding must be considered as tentative given the small sample size of patients within Breslow category 2. Therefore, further investigations should examine a higher number of melanoma cases with high values of Breslow thickness. In addition, it has to be considered that we performed a high number of statistical comparisons, which increases the possibility of obtaining significant p-values by chance.
To our knowledge, this is the first association study on melanoma and mitochondrial CR polymorphisms. To date, mutations within the D-loop are of unclear relevance, but they may influence the level of transcription and/or replication of the mitochondrial genome [5].
In the present study, we evaluated CR germline polymorphisms of the mtDNA of melanoma patients as possible risk factors for melanoma formation and progression, taking into account clinicopathological data.
The T16189C variant in the CR region has been associated with several other multifactorial disorders [29], [34], [35], including endometrial cancer [36]. The T to C substitution at position 16189 frequently generates an uninterrupted poly-C tract (np 16180–16195) in the D-loop. Furthermore, this variation often leads to heteroplasmic length variation of the poly-C tract (>10 cytosines) in different mtDNA molecules of a single person [29], [37]. When the T16189C polymorphism is accompanied by a second nucleotide change, which is often the case at np 16192, the poly-C is interrupted again. Liou et al. showed that different poly-C variants showed differences in mean mtDNA copy numbers [38]. Subjects with an uninterrupted poly-C had the lowest mtDNA copy number, whereas subjects harboring an interrupted poly-C showed the highest mtDNA copy number. These findings support an earlier assumption that the T16189C variant may affect mtDNA replication [39] because np 16189 is very close to the termination-associated sequence of the D-loop [40]. Within our melanoma cohort, the variant with the interrupted poly-C showed significantly elevated frequencies in melanoma cases compared to controls (p=0.001). We assume that this variant may alter mean mtDNA copy number also in melanoma cells. Concerning the T195C and C16270T polymorphisms, it is unclear whether these polymorphisms may be involved in tumor formation or disease progression as there are, to our knowledge, no data available showing their effect on mtDNA replication and transcription.
We further analyzed Breslow thickness of the tumor and metastasis to determine whether a certain haplogroup or CR polymorphism within the melanoma cohort correlates with tumor invasiveness or disease progression. The A302CC-insertion, which we found to be associated with a higher mean Breslow thickness, and the T310C-insertion, which was related to lower mean Breslow values, are both located within a poly-C stretch of HVR II. This C-stretch is of interest because it is involved in the formation of the persistent RNA-DNA hybrid that leads to the initiation of mtDNA heavy-strand replication [41]. Therefore, alterations of this region, in analogy to the T16189C variant, might have an impact on transcription and replication of the mitochondrial genome. The T16519C substitution was found at a higher frequency in patients with malignant melanoma and metastases, indicating a potential link to disease progression. Previously, this polymorphism was found to be associated with increased breast cancer risk [23] and with worse prognosis in pancreatic cancer [42].
In conclusion we report for the first time an association of mtDNA variations and malignant melanoma and its clinical parameters, Breslow thickness and metastasis. Therefore, genetically determined variation in mitochondrial function has to be considered, among other factors, as a potential contributor to malignant melanoma development.
The study was conducted according to the Austrian Gene Technology Act and complied with the Declaration of Helsinki. All subjects gave written informed consent before entering the study. The SAPHIR program was approved by the Local Province of Salzburg Ethics Committee ("Ethikkommission für das Bundesland Salzburg; Amt der Salzburger Landesregierung, Abteilung 9 Gesundheit und Sport").
Whole blood samples from 351 unrelated middle European Caucasians with malignant melanoma were recruited at the Department of Dermatology of the Paracelsus Medical University, Salzburg, Austria from April 2007 until March 2010. Patients with either melanoma in situ or melanoma in regression were excluded from the study.
The control population consisted of 1598 unrelated individuals, as previously described in detail [28], who were recruited for the Salzburg Atherosclerosis Prevention Program (SAPHIR). The mitochondrial haplogroup [43] and CR polymorphism [29] data were obtained from previous studies.
DNA was extracted from whole blood samples either by a modified salting out procedure as described by Miller et al. [44] or by using a NucleoSpin Blood Kit (Macherey-Nagel, Düren, Germany). A hierarchical system for mtDNA haplogrouping that combines multiplex PCR amplification, multiplex single-base primer extension, and capillary-based electrophoretic separation was used to assess the most common European haplogroups (H, U, J, T, K, I, V, W and X) as described in our pevious studies [45], [46]. Haplogroups that could not be assigned to one of the nine major European haplogroups by their single nucleotide polymorphism (SNP) combination were designated as "others".
CR sequences were generated by direct DNA sequencing between nucleotide positions 16024 and 526. Polymerase chain reaction and sequencing was performed as described previously [45]; however, a different forward primer (15997f: CACCATTAGCACCCAAAGCT) was used. Data were analyzed with Chromas software 1.56 (Technelysium, Tewantin, Australia) and alignment was conducted with Blast 2 software (bl2seq) (http://blast.ncbi.nlm.nih.gov/Blast.cgi). The Cambridge Revised Sequence was used as a reference (GenBank accession number J01415).
Frequencies of all mitochondrial haplogroups and CR polymorphisms were tested for independency from the disease using Pearson chi-square statistics and Fisher's exact test as appropriate. Only haplogroups and polymorphisms with a frequency ≥5% in either the melanoma or the control group were subjected to further statistical analysis. A p-value<0.05 was considered statistically significant. Association of A16183C, T16189C, C16192T, C16270T, and T195C with the disease state was adjusted for sex and age by logistic regression analysis.
The clinical parameters mean Breslow thickness and metastasis were analyzed within the melanoma cohort. Frequencies of all mitochondrial haplogroups and CR polymorphisms were tested for independency from the metastatic state using Pearson chi-square statistics and Fisher's exact test as appropriate. For comparison of mean Breslow thickness between different haplogroups and CR polymorphisms, Breslow data were logarithmically transformed and analyzed using a two-sample unpaired t-test. Adjustment for sex and age was conducted for A302CC-ins, T310C-ins, A73G and T16519C using logistic regression analysis.
All analyses were performed using PASW 18.0 (SPSS GmbH, Germany).
Control region polymorphisms of patients with melanoma.
Competing Interests: The authors have declared that no competing interests exist.
Funding: This study was supported by a grant from the Paracelsus Medical University Salzburg (07/05/027). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Michigan Libel Law: A Working Guide for Editors and Reporters
Michigan Press Association, 1953 - Libel and slander - 7 pages
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ACCURACY action for slander admissions amount awarded anywise arrest article attack Attorney award damages belonging book brought business cation charge of crime city Communist concerned confessed in open consent counties Crime stories CRIMINAL critic never declaration defamation defense dishonorable district EAST LANSING EDITORS enforce exemplary or punitive fair and true false fraud give notice Hamilton infer information inspect public journalism judge judicial Juries lawyer legislative bodies libel suit libelous statement malice matter Melvin Lostutter MICHIGAN LIBEL LAW Michigan Press Association Michigan Public Records Michigan State College Michigan Statute MISCONCEPTIONS misdemeanor mitigating never impute newspaper stories number office official proceeding open court opinion papers parties person Photograph picture plaintiff plea of guilty pleaded Police Blotters practical prejudiced presented print privileged proof prove public and official publishing a libel punitive damages readers reasonable report retraction right to inspect RULES OF PRIVACY special interest statute provides things township truth unless unsafe word

subset: commoncrawl


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The Department of English
You have a story to tell. You have worlds to read, and a future to write.
At the Department of English, you'll learn to express yourself with ease, force, and clarity, both on the page and out loud. You'll position yourself well for any career you choose. Most importantly, you'll take what you learn beyond the classroom to strengthen your community and change your world.
Join us. We'll help you read the world, and write your future.
'Miseducation of Cameron Post' named #1 Most Influential LGBT Book by Buzzfeed readers
The Miseducation of Cameron Post, a novel by emily m. danforth (PhD 2011), is #1 on a list of 16 of the Most Influential LGBT Books in Literature as determined by a survey of the BuzzFeed community. The novel was also recently featured on Bustle.com's list of 9 of Literature's Best LGBTQ Coming-of-Age Sexuality Stories.
The Price of Caitlyn Jenner's HeroismJune 4, 2015
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How to Apply
Let Curiosity Move you to start your story at the Department of English in the College of Arts & Sciences. With specialized programs of study to match any interest area, the opportunity for hands-on experience through our nationally-acclaimed undergraduate research program, and a campus located at the heart of an innovative college city of more than 250,000 people, the University of Nebraska-Lincoln offers the ideal Big Ten collegiate experience for students at an affordable cost.Apply Now


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O'Driscoll set for Liverpool role
Liverpool are set to confirm the appointment of Sean O'Driscoll as assistant manager on Monday.
|Participant name
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2021 or later
2017 or 2018
2019 or 2020
Liverpool are set to confirm the appointment of Sean O'Driscoll as assistant manager on Monday.
Manchester United winger Nani has arrived in Istanbul to complete a move to Fenerbahce.
Follow the MLS matches live on your mobile device with Sky Bet - no bet required!
Lewis Hamilton won an incident-packed British Grand Prix to claim back-to-back victories on home soil.
Golden Horn's owner-breeder Anthony Oppenheimer says he is "not enthusiastic" about the colt staying in training next season.
Andy Murray believes the roaring home crowd at Wimbledon can make all the difference in his bid for glory.
Andrew Strauss has warned Australia they will have to produce "outstanding cricket" if they are to win the Ashes in England.
A review of Sunday's action in the First Utility Super League, including a 100th career try for Danny Brough in Huddersfield's win.
Mark Cavendish blamed his Etixx-QuickStep team for losing a dramatic second stage of the Tour de France to Andre Greipel.
Sepp Blatter claims there were "political interventions" from France and Germany ahead of the 2018 and 2022 World Cup votes.


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text:
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Microalgae Oil to be featured in multiple skin care product lines.
Adds Dermalogica professional skin care brand
St. Moritz was the inspiration for one of PartyLite's new candles, with a fragrance by Tom Knotek.
Beauty Packaging celebrates its 20th anniversary this month, so we asked a esteemed industry experts for their thoughts.
The company has added Paul S. Michaels to its Board of Directors
Don't miss Beth Minardi, Minardi Color, George W. Schaeffer, Aloxxi Intl., and Harlan Kirschner, The Kirschner Group.
Tips to determine who's right—and who's not.
The winners will receive funding for their projects, and were celebrated at the 23rd World Congress of Dermatology.
The brand is telling consumers to #ForgetFlawless
An infographic by The Benchmarking Company
HairMax defines the small-space, hair-restorative, device market
How to approach global brand harmonization
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I can smell the desperation coming from Canonical...
No announcement yet.
Canonical Developer Criticizes Linux Mint's Security
new posts
Originally posted by who_me View PostWhen an Arch developer said about the same about Manjaro I saw nobody on Phoronix flip their shit. Actually, I don't even remember Phoronix covering it, but if someone at Canonical even farts, oh boy, oh boy, they (Phoronix and other outlets) will be all over that along with the hate bandwagon of trolls and zealots
Here. Have at boys!
But it's also true that Canonical/Ubuntu are much bigger than Arch and Manjaro, and with more power comes more responsibility.
Supposedly, all the linux distros are about openness and giving you a choice while cooperating with everyone else in the FOSS world without.
Linux Mint is one of the very few that actually acts that way.
So if Mint guys are disabling stuff - we all need to worry about that. What are the mint devs doing? Why? Are they actually pushing security stuff through a different route? If yes - what is it?
Originally posted by FLHerne View PostRespect for being scientific and producing data that should actually mean something - there really isn't enough of that around here.
That said, those Wikipedia numbers just look...wrong. No way does Ubuntu have 50x more users than other major distros like Fedora, Mint and SUSE; the 'Linux Other' column contains almost twice as much traffic as all other entries combined despite all major and some minor distros being shown individually.
Originally posted by prodigy_ View PostFirst, Arch is a non-profit community-based distro. Second, a random blog article doesn't mean they have an agenda. On the other hand Canonical obviously does (Mark & Co. rabidly attack everyone and everything they see as a threat starting with Wayland).
Like I said, rabid zealots and trolls. The phoronix forums are a cesspool.
Originally posted by Goddard View PostSaying DistroWatch is a bad source is just like when my teachers would say Wikipedia is a bad source. It always felt like a discrediting statement especially when I would write papers sourcing the material, but say it came from an encyclopedia. In other words it may not be as good as getting a piece of software on every single Linux system reporting which distro they are using, but it is as good as it gets.
However when one says Wikipedia is a bad source, I'd say no(mostly). Again statistics isn't always a good source, but Wikipedia isn't only a source of these data, but also many other things. When it comes to numbers, Wikipedia has a strict rule that avoids assumption of the relevance of those data, unless it is provably true, or the data was obtained from extra-high accuracy scientific measurements and has near-zero chance of a major error.
The conclusion: Wikipedia is not a bad source, but since it's not the same concept as DistroWatch, the (specifically) popularity ranking of DistroWatch is highly probably(I personally think it actually is, but I don't have proof) a bad source.
The truth is, if you are using anything other than a main distro and are focused on security; you're using the wrong distro. Things like Mint are for experimentation and hobby purposes.
Originally posted by prodigy_ View PostFirst, Arch is a non-profit community-based distro. Second, a random blog article doesn't mean they have an agenda. On the other hand Canonical obviously does (Mark & Co. rabidly attack everyone and everything they see as a threat starting with Wayland).
The developer adressed a valid point which should raise concerns about Mints handling of that issue and what other distributions could learn from that. Not start another shitstorm about canonical.
So what is your agenda here?
Originally posted by erendorn View PostOriginally posted by squirrlAny operating system that presents me with a guest account to log into without a password is a comprimised system.
Originally posted by hadrons123 View PostMint is vulnerable -- Agreed. No doubt.
Canonical is vulnerable too with kernel updates. They don't backport all the fixes done from kernel.org. Instead calling shots on Mint they should mind their own business of doing things right.
the kernel stable mailing list. They provide sources everyone can pick.
They are doing their job.
If derivative distros are not providing what it is known their upstream delivers, this attack against Mint was valuable transparency! Worth to know, thank you!
Are you people for real?
I'm looking through this thread and obviously there's waaaaaay too many Linux diehards in here. Are you people trying justify your delusions by saying that wikipedia has a long lasting bug that makes Canonical's Ubuntu more popular than your favorite distro? From the eyes of an outsider that joined Linux because of Ubuntu back in 2008, I have to wonder how you people are completely missing the point when it comes to marketing.


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As pretty much most of you know, I spend a lot of time doing School Talks, going to students around the world with my 'Change The Channel' talk, aimed at getting reluctant readers to get back into books, whatever type of book it is. It's popular, it's linked to above on the SCHOOL TALK and WORKSHOPS buttons, and most importantly it works. And, due to my writing workload, this year I've dropped down to only a couple of talks a month.
I've been contacting schools recently to let them know that I'm starting to book the remaining dates of the academic year, and I've had a couple of similar sounding conversations this week.


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Common examples of construction applications include curing concrete, structural testing, temperature monitoring of building materials, vibration monitoring, and more. CAS Datalogger offers many durable and weatherproof datalogging solutions monitoring temperature, vibration, pressure, force, and more, along with vibrating wire strain gauge support.
Temperature Monitoring of Cooling Metal for Quality Welds
Published on December 18, 2014
Manufacturer: dataTaker
CAS DataLoggers provided the dataTaker datalogger solution for a welding company working on a wide variety of metal parts. Welders first have to preheat the metal before welding, so they needed a temperature monitoring system to display the metal temperature and ensure a quality weld.
Monitoring and Repairing a Natural Historic Landmark
Published on February 24, 2014
Manufacturer: dataTaker
CAS DataLoggers has just provided the structural monitoring technology for the Los Angeles County Museum of Art (LACMA), which has begun work on their newest conservation project--the Watts Towers, a Los Angeles monument and a masterpiece of regional folk art. The Towers were named a National Historic Landmark in 1990, with the tallest structure reaching to a height of about 100 ft.
Determining Concrete Maturity Using Temperature Data Loggers
Published on April 29, 2013
Manufacturer: Grant Instruments
CAS DataLoggers has provided the temperature data loggers for a construction contractor which needed to monitor and record the cure of structural concrete onsite. Once workers could prove that the concrete was strong enough, they could then proceed with new construction. The company was on a tight work schedule, so they wanted to assemble all the necessary equipment and calculate the cure strength as quickly as possible.
Recording Road Surfacing Data to Prove Process Efficiency
Published on February 25, 2013
Manufacturer: dataTaker
CAS DataLoggers recently provided the intelligent data logger solution for a company owning several bitumen spray trucks used to seal roads and highways. Management wanted to demonstrate their process quality to customers by recording specific information during multiple bitumen spray runs. This data would have to be collected from sensors recording several different parameters including the temperature of the bitumen, the surrounding air, engine RPM, road speed, and more.
Improving Concrete Testing by Duplicating Real-World Conditions
Published on December 3, 2012
Manufacturer: dataTaker
A large manufacturing technology company contacted CAS DataLoggers after being asked to develop a method for testing the cure and strength of structural concrete in the field. Reproducing real-life curing conditions in a lab would enable the company to accurately estimate the concrete strength faster than possible under conventional methods. For this application, a monitoring and alarming data logger was needed, and remote data communication and transmission were must-have capabilities.
Load Cell Monitoring in a Tunnel Jacking Operation
Published on November 5, 2012
Manufacturer: dataTaker
CAS DataLoggers recently provided the dataTaker DT80 datalogging solution for Custom Systems & Controls, Inc., specializing in system design, process control and automation. CSC was contracted by SECAC Tunneling of Baltimore, MD to design and build a flexible monitoring system for their project to excavate a tunnel in Quincy MA, near the Boston area. Workers needed to monitor the tunneling equipment by logging tensions (force) from load cells, hydraulic pressure, and moveme...
Temperature and Humidity Monitoring Protects Building Insulation
Published on September 25, 2012
Manufacturer: Grant Instruments
CAS DataLoggers recently provided the temperature and humidity monitoring solution for a large manufacturer of insulation materials. The company's insulation material was absorbing a significant amount of moisture in storage and transit, so they wanted to conduct a microclimate study of the best ways to pack their product and needed a portable temperature and humidity monitoring solution durable enough to withstand exposure to the weather.
Residual Load Testing of Anchor Bolts
Published on May 22, 2012
Manufacturer: dataTaker
CAS DataLoggers recently supplied the data logging solution for a world-leading manufacturer of masonry fasteners. As part of their product development, company engineers needed to measure the peak installation load and to monitor how the load reduced as the newly- installed fastener bedded in. Designers needed to determine such factors as bolt tightness over given periods of time (months/years) when calculating the required capacity for fastening beams in buildings or for ...
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Have I ever told you I love http://afuchan.tumblr.com/? Maybe I have but let's say it again: I love Afu Chan! His art has the popular post-Moebius line mixed with action packed layouts and weirdly angled figures that are just irresistible and his character designs are gorgeous. It's surprising he hasn't gotten a lot more attention, but his output has been rather limited. I loved his work on Spera and his illustrations, and now he's back with HaloGen, written by Spera's Josh Tierney ; Giannis Milonogiannis (Prophet, Old City Blues) is a co-creator of the series and contributes covers.
Nice art: Josh Tierney, Afu Chan and Giannis Milonogiannis are back with HaloGen
Review: Friends with and without feathers flock together in Feathers #1
Writer/Artist/Creator Jorge Corona gives us a lot to chew on in issue one of his new series Feathers: there's a disembodied duo who appear only in voice over; a gleaming white-walled citadel surrounded by poorer districts and a class system to match; a faceless, whistling villain who preys on children and never forgets his muffler; and, of course, a little boy covered in the feathers that gives the book it's name.
15 Days of Boom!: 'Spera: Ascension of the Starless' is coming
Josh Tierney's Spera is one of the best looking webcomics/graphic novels out there with work by a bevy of amazing artists such as Emily Carroll, Michael Dialynas, Meg Gandy, Cory Godbey, Amei Zhao and Sam Bosma….and more. The web versions have been collected by Boom/Archaia into three hardcovers thus far. And now an all new […]
NYCC Panel Report: We Are Boom!
Boom! Studios gets 'innovative' first look deal with Fox
Somewhere in the Long Slog Of 2013's Comic Book Movie summer, I probably suggested that 2 Guns might end up being the most important film in terms of how Hollywood deals with comics properties (relatively low budget non superhero fare); how true that will be remains to be seen but it DEFINITELY was the most important film for Boom! Studios. They've just signed a first look deal with 20th Century Fox, that, at least in the hype rollout, sounds promising in terms of how it involves comics creators:
Here's All Our News from SDCC in One Place
One of the things heard most frequently this weekend online was 'why is there no comic news coming out of SDCC'? You mean aside from the masses and masses of comics news which came out of the convention, right? The Beat covered basically every single comics company you can imagine, and we've still got a […]
SDCC'13 in Photos: Archaia, Cosplay, Joss Whedon and Hugs
We're almost reaching the end of San Diego Comic-Con 2013, but before packing her bags and heading back to Chicago, Megan Byrd (@comicbookcandy) has sent two last sets of photos from the festival. There's cacti made out of yarn, Spider-Man being a dick to Darth Vader, all kinds of amazing cosplay, and shots from Archaia, Boom […]
Archaia Announce a Graphic Novel from Alyssa Milano
Archaia have today announced that they'll be publishing a graphic novel, HACKTIVIST, conceived by actress Alyssa Milano. The novel, which will be written by Jackson Lanzing and Collin Kelly, will be drawn by Marcus To, coloured by Ian Herring, and lettered by Deron Bennett. That's quite a formidable creative team backing up the story!
Boom! Studios acquires Archaia
Well, well. While the general state of comics is pretty healthy these days, there had been one company whose well-being we continually heard whispers about, and that was Archaia: an ill-timed move to a bookstore distributor two years ago left them with massive returns and a lot of cash flow problems. None of these ever […]
Nate Cosby and Chris Eliopoulos Launch Cow Boy: Unconquerable
5 Recent Graphic Novels You Don't Want to Miss
These graphic novels have been chosen because they were all released in the past 6 months and equally combine qualities of well-crafted concepts and remarkable artwork to create solid visual narratives. They aren't the only great graphic novels that have been released in recent months, but they are notable, and worth considering as near-misses if […]
REVIEW: Gaming and Comics Collide in HAWKEN:GENESIS
Archaia, who makes a strengths out of the crossroads between comics and other visual media, has taken on another estuary zone in HAWKEN: GENESIS, bringing a comic based on a free internet gaming hub, HAWKEN to readers. Flood zones between visual media can be tricky, especially in gauging the right audience for a comic, since […]
On the Scene: WonderCon 2013 Recap and Photo Gallery
As I suggested in my early con impressions, WonderCon had a reasonable amount of space and handled the numbers of attendees pretty well. It was no surprise that Saturday brought bigger numbers than Friday, and the crowding was more obvious, but still never reached that feeling of pushing and shoving that can easily erupt at […]
iverse and Archaia team up
Archaia's stellar line-up of fantasy, children and licensed comics—from Eisner Award-winning Mouse Guard and Return of the Dapper Men; fan-favorite series such as Rust, Jim Henson's The Dark Crystal, and Fraggle Rock; and new releases such as Cursed Pirate Girl and Iron: Or, the War After—will soon be available via iVerse's Comics Plus app, starting in March.
First Look: Mignola and Stewart draw Mouse Guard for The Black Axe #6
The final issue of Mouse Guard: The Black Axe #6 goes on sale next week, and it wraps up not only the origin of the legendary Black Axe but a series of pin-ups that run in each issue. #6 features a pin-up by the team of Mike Mignola and Dave Stewart. David Petersen's fantasy epic starring mice has always been equal parts cute and majestic and Mignola/Stewart have nailed the vibe.


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You can now invite anyone to meet at your favorite Starbucks.
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34 year old man | New York, NY, USA | Seeking women 21-33 within 60 miles
Active within 3 days
I'm a big kid at heart. I'm super spontaneous...
I'm a big kid at heart. I'm super spontaneous and really just try and enjoy life as much as I can. As I was pretty much raised around women my whole life. I really appreciates the little things and am always looking with the whole glass half full mentality. I'm bilingual in English and Sarcasm. So if you can't laugh at yourself and take things too seriously then please save yourself the time and move on to the next profile. I bust chops and appreciate a smart clever wit in return. I'm very playful and if that's not up your alley, I wish you good luck with someone else. Curiosity and being spontaneous are part of my personality. I love learning new things and find it attractive if you can teach me something. My curiosity has brought me to challenging one of my dogs ( who loves belly rubs) to see how long she would go until she got bored by me rubbing her belly. She won after almost three hours at which time I stopped to grab for a drink and she started gesturing with her paws to continue. So....my little pomeranian beat me. But I'm competitive so this is not over doggy!! I absolutely love my job and don't fee like i have so called "work". Even though I had to graduate the 20th grade, it was all worth it as I get to be intimately involved in a person's journey to regain their body's health. You might call me a self proclaimed dork, who still believes a hand written card carries more weight than a text/email. I think it says a lot about someone on how they treat strangers. You never know who you are talking to or what can be learned from them. If you sit on a high horse then please.......keep it moving :P My lifestyle is very active. You will find me playing baseball, training jiut jitsu, boxing, going to the gym, and having way too much energy at times. My down time I like hanging in watching a movie or going out to actually do something. The bar/club thing is fun here and there but I'm really not into that whole scene on a regular basis. I rather go see a comedy show, play pool, ping pong, go to an animal shelter or whatever little adventure pops up. However I must admit I'm a big fan of cuddling up on the couch. I am a sucker for a bright smile, affectionate, driven, optimistic, fit, smart woman with a warm heart to match. I believe having a strong physical attraction is a big part of the equation and if its not there then it won't work. It is what starts the spark, but if there is nothing beyond that then interest is lost very quickly by both sides. Fitness is part of my life and if you are the same we'll get along just fine. Winks are cute but messages are more likely to catch my eye. Good luck to everyone's search!!
Alumni connections , Book club , Camping , Coffee and conversation , Business networking , Cooking , Dining out , Fishing/Hunting , Gardening/Landscaping , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Playing sports , Shopping/Antiques , Travel/Sightseeing , Video games , Volunteering , Watching sports
Aerobics, Auto racing / Motorcross, Baseball, Basketball, Billiards / Pool, Bowling, Dancing, Football, Golf, Martial arts, Other types of exercise, Running, Swimming, Tennis / Racquet sports, VolleyBall, Walking / Hiking, Weights / Machines, Yoga
I exercise 5 or more times per week.
Don't display my sign
I have Cats, Dogs
I like Exotic Pets, Fish, Gerbils / Guinea Pigs / Etc., Horses
baseball diamond,patsy's pizza (the real one), serendipity ( love frozen hot chocolate), central park, union square, my couch
New York University, New York, NY
love the feeling of accomplishment, the way stupid things make me laugh, people watching, playing catch ( i can play all day)
baseball, jiu jitsu,working out,hanging with my friends/family, playing in the sun, eating chocolate chip cookies (with milk of course), reading (research articles to non fiction), throwing snowballs, staying in when its cold, going out when its warm
myofascial release, the athletes shoulder, clinically oriented anatomy, blink
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|6'0" (182cms)
|3'0" (91cms) to 8'0" (243cms)
|Body type:
|Athletic and toned
|Slender, Athletic and toned
|No preference
|Light brown
|No preference
|No Way
|No Way
|I'll tell you later
|No preference
|I'll tell you later
|No preference
|I'll tell you later
|No preference
|Never Married
|Never Married
|Have kids:
|Wants kids:
|No preference
|White / Caucasian
|Asian, East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian, Other
|I'll tell you later
|No preference
|No preference
|PhD / Post Doctoral
|Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


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Quality Suites Blue Ash
Quality Suites Blue Ash
Hotel Guest Rating: 7.9/10
11349 Reed Hartman Highway
Cincinnati, OH 45241
Welcome to the Quality Suites Blue Ash
Spacious suites at reasonable rates and a quaint New Orleans-style atrium lobby please Priceline guests at Quality Suites Blue Ash.
Hotel Features
The hotel features manicured surroundings, a charming open-air lobby with brick flooring, plump sofas and armchairs, indoor landscaping and wrought-iron balconies. The 50 spacious suites have microwaves, mini-fridges and coffeemakers. There's a guest computer in the lobby and the hotel serves a free full breakfast daily. Take a dip in the seasonal outdoor heated pool or raise your heart rate at the fitness center. Dry cleaning service is available.
Hotel Location
Conveniently located in the Blue Ash business district, 20 miles north of downtown, the hotel is near family attractions. It's one-and-a-half miles from Sharon Woods, with hiking and biking trails, fishing and golf, and nine miles from Kings Island Amusement Park. Cincinnati/Northern Kentucky International Airport is 33 miles away.
Guest Favorites
For "large and spacious rooms" plus a touch of New Orleans charm in the midst of the Midwest, Quality Suites Blue Ash is a good option for Priceline guests.
Quality Suites Blue Ash Amenities
- AM/FM radio
- Bus parking
- Cable television
- Complimentary full american breakfast
- Elevators
- Exercise gym
- Free high speed internet connection
- Free movies/video
- Hairdryer
- Handicap rooms
- High speed internet connection
- Laundry/Valet service
- Microwave
- Non-smoking
- Outdoor parking
- Outdoor pool
- Parking
- Pay per view movies on TV
- Ramp access
- Refrigerator
- Safe deposit box
- Telephone
- Wireless internet connection
Hotel Information
You must show a valid photo ID and credit card upon check-in. Please note that all special requests cannot be guaranteed and are subject to availability upon check-in. Additional charges may apply. Guests are required to show a photo identification and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply.
Hotel Guest Reviews of the Quality Suites Blue AshOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
June 26, 2015
Family Traveling with Teens
June 22, 2015
May 29, 2015
Family Traveling with Young Children
May 19, 2015
Solo Traveler
January 26, 2015
August 19, 2014
Nice atmosphere.room and excellent staff.
July 12, 2014
Business Traveler
This guest did not leave comments about this hotel.
July 1, 2014
overall we had a good experience. clean room, enough parking, friendly staff, good times.
May 20, 2014
Solo Traveler
April 29, 2014
Business Traveler
The room was bigger than I expected and had a nice, somewhat separate, lounge and desk area in the first part of the room. It was stocked with toiletries, coffee, and a nice luggage closet.
(1 - 10 of 13 reviews)
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Most Popular Guest-Rated Hotels in Cincinnati
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3 86880 Hepa Filters For Sears Kenmore Vacuums.$9.00~4 1/4 x 3 inches.
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1 & 1/4 Inches Deluxe Floor Brush For Most Vacuum Cleaners.
Special Price: $7.82
Original: $8.16Fit all floor brush fits all vacuums that accept standard 1 1/4\" (32MM) inside diameter attachments. Deluxe floor brush is 12\" wide, has natural horse hair bristles and two non marking rubber wheels. 360 degree swivel neck allows for very easy cleaning of any hard surface. Learn More
2 Washable And Reusable Hepa Filters For All Bagless Hoover Windtunnels$8.87Our filters are washable and reusable. Rinsing the filter under a faucet should be sufficient in most cases, mild household cleaner can be sprayed on, if desired. And, of course, fully dry before using. Filter fits inside the dust compartment in Hoover bagless uprights with a Twin Chamber System including these popular models U5260900, U5260950, U5262900, U5262910, U5263900, U5265900, U5265955, U5266950, U5268900, U5268950, U5268970, U5269900, U5269955, U52719RM, U52729RM, U57009RM, U5720950, U5720960, U5725900, U5725960, U5750906, U5752900, U5753900, U5753950, U5753960, U5753980, U5760900, U5760910, U5768900, U5786900, U66009RM, U6607900, U6616900, U6617960, U6618900, U6630900, U6632900, U6634900, U6637900, U6637960, U8120900, U8140900, U8147900, U8153900, U8155900, U8161900, U8171900, U8172900, U8173900, U8173950, U8174900, U8174950, U8181900, U8181950, U8183900, U8185900, U8187900, U8187950, U8188900, UH40020, UH40065, UH40110, UH40115CA, UH40125, UH60000. Also refered to as as a Type 201 filter, 43611042 filter or 42611049 filter. Also replaces filter #40140202. Approximately 11 3/4" x 3". Change every 3 to 6 month Learn More
2-PACK of F1 HEPA Filters for DIRT DEVIL vacuums. WASHABLE and REUSABLE. By Green Label.$15.002-PACK of F1 HEPA Filters for DIRT DEVIL vacuums. WASHABLE and REUSABLE. By Green Label. Learn More
Results 1 - 12 of 12


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Consultancy Design Engineering jobs in United Kingdom
Found 4 jobs matching your criteria
Order by: Newest first Salary
Director, Transportation Planning/Engineering Infrastructure (Head of Practice)
- Bristol (City Centre), City of Bristol
- Circa £60,000 + Benefits - dependant upon experience
Highly experienced transportation planner or transport engineer required for a Director level post - to run a transportation practice in Bristol.
Mechanical Engineer - Innovative and Entrpreneurial Design House
- Cambridgeshire
- Circa £50,000 plus excellent package
They need to grow their design team and are looking for someone with first class engineering skills.
Senior HVAC Design Engineers
- Kent
- £35.00 - £40.00 per hour
Great long term opportunity to join this international Building Services Consulting Engineers in their Kent office They are looking for three engineers to j...
Senior Electrical Engineer
- Manchester
- £40000.00 - £50000.00 per annum + Full Package
My client is an independently owned multi-disciplinary consulting engineering practice with several offices across the UK, providing building services to a w...


text:
Rio de Janeiro is world famous for its churrascarias (grilled-meat restaurants) but there's more to its dining scene than sizzling cuts of meat: the city embraces all types of cuisine, from traditional set meals of meat, rice, and black beans to upscale French cuisine. Unlike the states of Bahia and Minas Gerais, Rio doesn't have an identifiable cuisine, though its coastal location ensures
that fish and seafood dishes are a staple of many menus here. Vegetarian cuisine has become more visible over the past half-decade. Non-carnivores can feast on a vast range of vividly colored fruits and vegetables at a number of health-food spots. Don't leave Rio without enjoying a relaxed meal and drinks at a traditional boteco (casual bar-restaurant), or taking your pick from the heaping buffets at a comida-a-kilo (pay-by-weight) restaurant.
Eager to explore the U.S.? Our trip finder will help you find the perfect destination.More
Fodor's Rio de Janeiro & Sao PauloView Details
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Anatoly Frenkel Pioneers New Technique to Track Chemical Reactions Under Real Operating Conditions
The Science of Self-Defense
Yeshiva University Faculty Receive Grants from U.S. Department of Defense Agency
Wurzweiler Students to Help High-Risk Adolescents
$1.4 Million Grant Will Train Students to Work With Vulnerable Youth Drug abuse, multiple trauma experiences, underachievement and a 10 percent high school dropout rate are just some of the problems faced by adolescents growing up in high-risk environments, often leading to mental health disorders that need to be addressed. A new grant awarded…
The Secrets of Nanocrystals Unlocked
Anatoly Frenkel Receives $375,000 NSF Grant to Support Three Years of Joint Research with Hebrew University
Why Live Forever?
Yeshiva College Professor Wins $34,000 Grant for Project that Tackles the Inherent Value of Immortality—Or Lack Thereof
Ferkauf Clinical Psychology Program Wins APA Grant
2014 Varda Shoham Clinical Training Initiative Grant Will Help School Bridge Gap between Research and Clinical Practice The clinical psychology program (PsyD) at Yeshiva University's Ferkauf Graduate School of Psychology has been awarded the 2014 Varda Shoham Clinical Scientist Training Initiative grant, a highly competitive award from the American Psychological Association (APA)'s Society for a Science…
The Battle for Israel's Soul
At Straus Center Event, Author Daniel Gordis Discusses The Life and Legacy of Menachem Begin
Investing in Creative Kindness
Yeshiva University Announces Micro-Grants for Student Social Entrepreneurs Yeshiva University recently announced a new fund that will provide micro-grants to student social entrepreneurs founding startups that will benefit the broader Jewish and global communities. Called "Neal's Fund," the initiative was created by the family of Neal Dublinsky. Dublinsky grew up in Queens, NY, and graduated…
Straus Center Commemorates Begin's 100th Birthday
Menachem Begin Heritage Center Grant Supports YU Programming Honoring Former Prime Minister's Legacy
Einstein-Ferkauf Researchers Secure $2.5 Million NIH Grant
Researchers to Study Diabetes Self-Management and Behavioral Interventions More than 25 million Americans have diabetes, yet as many as 60 percent of type 2 diabetes patients do not follow treatment plans prescribed by their health care provider and about 50 percent fail to meet treatment recommendations for control of blood glucose levels. Consistent adherence to…


text: Holy shit, What the fuck!?!? Flag By: pellonpoika (More by author: Most viewed, Newest, Most Thumbs) previous next random - Fav + Fav Comment In Russia, fences attack you! Tags: hit | wind | storm | russia Recommend tagsx +287 Views: 14824 Favorited: 8 Submitted: 05/11/2013 Share On Facebook Remove from favorites Add to favorites Unsubscribe from pellonpoika Subscribe to pellonpoika


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NRA Official Silhouette Targets B-34 25-Yard Paper Package of 100
Product #: 629282 NRA #: B-34
- Information
Official NRA targets suitable for scoring matches or for match simulation during practice.
Technical Information
Dimensions: 14" x 24"
Reduced from 50-yard B-27
Technical Information
Dimensions: 14" x 24"
Delivery Information
The total weight of the product, including the product's packaging as it sits on our shelf. Since some products ship directly from the Manufacturer, their weight may be unavailable. Because of variations in the manufacturing process, similar products may have differing weights. Unless the product is designated as "Ships Alone", Shipping Weight does not include the shipping box or packing materials associated with your order.
Product ships from MidwayUSA, separate from any other products on your order due to its size. Products that are Shipped Alone incur separate "Per Order" and "Per Pound" shipping charges.
Product is regulated by the US Department of Transportation (DOT) and cannot be shipped via USPS or air shipping methods. DOT-Regulated products must ship UPS Ground.
Product is restricted by shipping carriers and cannot be shipped to certain locations or via certain shipping methods.
Additional shipping charge for HazMat products. Carriers charge extra to ship packages with products they consider hazardous, such as reloading powder and primers.
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"[Pierce] is doing a great job," Andray Blatche said. "He's forcing him to take shots, LeBron is trying to back him down, Paul is a strong guy himself, so he is just playing cat and mouse with him."
Perhaps it's no coincidence that Miami's shot attempts near the rim have gone down with each game from 29 in Game 1 to 18 in Game 2 to 13 in Game 3, according to NBA.com.
Outside of that first quarter in Game 3 when he made 4-of-5 shots against Pierce, James is shooting 4-of-11 against the former Celtic swingman in the series, including 0-for-2 over the last three quarters of Game 3.
After the Game 3 loss, James didn't leave the court immediately, choosing to take in a long look toward the Nets bench as fans in the Barclays Center celebrated the victory. It was as if James was taking a mental note of the moment and already beginning to motivate himself for Game 4.
James, however, displayed no concerns about seeing the Heat's lead in the series cut to 2-1.
"I feel real good about our team, why wouldn't I? I'm on the team," James said.
Pierce is looking forward to the challenge.
"I don't have the offensive load that I had in the past where I set on having to carry us all the way offensively and then take the best defensive assignment," Pierce said. "Now I can reserve a lot of energy toward trying to defend him. When the time comes for me to score, then I'll do that also."
Information from ESPN.com's Brian Windhorst contributed to this report.


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I'm pretty close with my family, and we do a lot together. My younger brother has lived with me for the past few years now, and I have the sweetest pup in the world. Aside from her destructive puppy phase, I couldn't have asked for a better dog. I'm not much of a sports nut, but I enjoy the occasional game. I tend to be a bit of a homebody at times. I enjoy playing video games, but I don't play nearly as much as I use to. I can be a bit old-fashioned in sense, and don't necessarily keep with the times. I like classic rock, older cars and stick shifts. I'm not big on flat screens or smart phones.
I am pretty set in my life, and would like someone to share it with. Most people I know tend to be surprised I'm not with anyone. I can be a tad shy and sometimes it's hard to meet new people, outside of work and my friends. I can be a bit picky, but I know what I'm looking for and I'm not interested in settling or getting stuck in a bad relationship. I don't feel the need to be with somebody. I actually enjoy the freedom and luxuries of being alone, but I would love to find that special someone.
I'm looking for someone that is cute, fun, sweet, down-to-earth, smart and a little goofy. I'm not looking for someone that's superficial, high maintenance, or a picky eater. An open mind and healthy appetite is a must, and find nerdy or crafty girls very attractive. I love to lose myself in someones eyes, or feel the warmth of a pretty smile.


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No One Left to Lie to: The Triangulations of William Jefferson ClintonPaperback
List price $14.99
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Additional formats available
- Format
- CD-Audio $19.43
- Publisher: Little, Brown & Company
- Format: Paperback | 194 pages
- Dimensions: 132mm x 201mm x 18mm | 318g
- Publication date: 4 October 2012
- Publication City/Country: New York
- Sales rank: 97,881
Product description
"Just as the necessary qualification for a good liar is a good memory, so the essential equipment of a would-be lie detector is a good timeline, and a decent archive." In NO ONE LEFT TO LIE TO, a New York Times bestseller, Christopher Hitchens casts an unflinching eye on the Clinton political machine and offers a searing indictment of a president who sought to hold power at any cost. With blistering wit and meticulous documentation, Hitchens masterfully deconstructs Clinton's abject propensity for pandering to the Left while delivering to the Right, and he argues that the president's personal transgressions were ultimately inseparable from his political corruption. Hitchens questions the president's refusals to deny accusations of rape by reputable women and lambasts, among numerous impostures, his insistence on playing the race card, the shortsightedness of his welfare bill, his ludicrous war on drugs, and his abandonment of homosexuals in the form of the Defense of Marriage Act. Opportunistic statecraft, crony capitalism, "divide and rule" identity politics, and populist manipulations-these are perhaps Clinton's greatest and most enduring legacies.
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Author information
Christopher Hitchens was a contributing editor to "Vanity Fair," "Slate," and "The Atlantic," and the author of numerous books, including works on Thomas Jefferson, Thomas Paine, and George Orwell. He also wrote the international bestsellers "god Is Not Great: How Religion Poisons Everything," "Hitch-22: A Memoir," and "Arguably." He died in December 2011.
Review quote
"Christopher Hitchens is a remarkable commentator. He jousts with fraudulence of every stripe and always wins. I regret he has only one life, one mind, and one reputation to put at the service of my country." "Joseph Heller""


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Kukla's Korner Hockey
Morning Line
by Paul on 12/28/13 at 11:31 AM ET
Comments (0)
"We started pretty well. We kept pace and then, all of a sudden, we just quit and all of a sudden we don't play ice hockey anymore.
"I think we try and we want to play well but we just can't for 60 minutes. It's the small things. It's not anything major. It's just that extra bump, extra stride or extra pass.
"We can't string it together for a long period of time and then it's going to be back in the back of our net."
-Erik Karlsson of the Ottawa Senators after losing to Boston 5-0 last night. More on the Senators from Bruce Garrioch of the Ottawa Sun.
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Connor McDavid Fever Is Upon Us
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About Kukla's Korner Hockey
Paul Kukla founded Kukla's Korner in 2005 and the site has since become the must-read site on the 'net for all the latest happenings around the NHL.
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Meshell Brown Takes Readers on a Wild Ride into the World of Crime
Meshell Brown debuts in the world of literature with a novel depicting the savage underworld of drugs and crime and its intersections with the lives of people ensnared in it. Lovin' a Thug is a sizzling and intricate tale of love and lust, loyalty and betrayal and of men and women who would do anything for a second chance.
The story introduces Tilmon, top dog in the world of drug dealing; his girlfriend of five years, Tasha and his sister and only surviving family, Lyric. These three lead double lives, one in the lap of luxury and the other in the midst of the most ruthless criminals of the United States. After a drug deal goes wrong, the three are once again forced to go on the run-an incident that will put into motion a series of dangerous events that will change each of their lives forever. Tilmon, Tasha and Lyric will soon learn that in the high-stakes game they are playing, love and freedom has the highest price of all.
Fast-paced and brilliantly orchestrated, Lovin' a Thug will send readers on a rollercoaster ride into a perilous world where nothing is quite what it seems.
For more information on this book, interested parties may log on to http://www.Xlibris.com.
About the Author
Author info needed.
Lovin' a Thug * by Meshell Brown
Publication Date: February 20, 2013
Trade Paperback; $19.99; 161 pages; 978-1-4797-7297-1
Trade Hardback; $29.99; 161 pages; 978-1-4797-7298-8
eBook; $3.99; 978-1-4797-7299-5
Members of the media who wish to review this book may request a complimentary paperback copy by contacting the publisher at (888) 795-4274 x. 7879. To purchase copies of the book for resale, please fax Xlibris at (610) 915-0294 or call (888) 795-4274 x. 7879.
For more information on self-publishing or marketing with Xlibris, visit http://www.Xlibris.com. To receive a free publishing guide, please call (888) 795-4274.
About Author
- Casting Roundup: Sarah Chalke, Kim Raver Headline New Pilots
- ADVENTURE TIME Headed to the Big Screen?
- Pilot Season Roundup: Colm Feore, Daniel Stern, Dave Annable to Star in New Shows
- James Franco to Star in New Fox Comedy, WHY HIM?
- Christopher Meloni to Star in WGN America's Slave Drama UNDERGROUND
- Check Out Alex Dunphy's Full College Essay from Latest MODERN FAMILY Episode
- Photo Flash: HBO Reveals Key Art for GAME OF THRONES Season 5
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- Grammy Winner Kelly Clarkson Exclusively Premieres New Music from New Album on MTV, VH1 & CMT First
- CONSTELLATIONS' Jake Gyllenhaal and Ruth Wilson Set for THEATER TALK This Weekend


text:
On our latest 30-minutes-or-your-pizza-is-an-emoji tech podcast, PCalc developer James Thomson and Macworld editor Susie Ochs join me and Jason to talk product reviews, Apple Watch apps, self-driving cars, and Facebook's new Instant Articles.
Unjustly Maligned 11: Hudson Hawk
The podcast is Unjustly Maligned. The episode is number 11. The guy on a donkey's just a guy on a donkey.
When Antony Johnston asked me to be on his podcast, in which people defend underrated works of art, I jumped at the chance to speak in favor of one of my favorite movies, the 1991 Bruce Willis action-adventure vehicle Hudson Hawk. As it turns out, Antony is also a fan, and so the two of us spend almost an hour waxing rhapsodic over this panoply of slapstick, one-liners, and surreal humor.
Arrow S3E22 Review: "This Is Your Sword"
Guy English and I discuss the penultimate episode of Arrow, group rates on flights to Nanda Parbat, and why you can't just kill everybody on the show.
(Also, I missed linking to last week's Arrowcast, in which we covered episode 21, also known as "Ollie is the villain of the week.")
Stay Foolish 2: Could Apple become its own cellular carrier?
The second installment of my new column on a little publication called Macworld asks whether Apple might follow in the footsteps of Google and launch its own wireless carrier. I run down the arguments for and against.
(My first column, which ran last week, speculated about Tim Cook's comments on the future of media during Apple's most recently quarterly conference call.)
Also, many people have asked me if it's weird to be back writing for Macworld. Not really: I've always enjoyed the publication, since well before coming onboard as a staffer in 2007, and I'm delighted to be be able to write for them once again. Plus, I really enjoy, you know, eating food and having a roof over my head, so it's a good deal all around.
The Rebound 33: Just a Bunch of Nerds
This week, Lex bosses us around, I make up words, and Moltz really wants an iPad Pro for watching TV. Which some of us have a TV for, but sure, whatever. That and, of course, unending talk about the Apple Watch.
Clockwise 86: Buzzing My Wrist
This week on our 30-minutes-mostly-about-the-Apple-Watch we welcome a special duo: David Sparks and Katie Floyd of the Mac Power Users podcast, which recently joined our home network, Relay FM. We talk about rumors of an Apple touchscreen remote, how distracted we are (if at all) by the Apple Watch, our favorite home automation tips, and which watch face we're using.
Inconceivable! 3: Mogo is Displeased
Our nerdy game of trivia and tribble-ations is back, with panelists Christa Mrgan, Guy English, Maddy Myers, David Loehr, Liz Myles, and Tony Sindelar. This month we tackle our usual collection of jargon, Game of Thrones's immense catalog of death, and monstrous movie puns.
Clockwise 85: Squeals of Joy and Pain
On this week's 30-minutes-no-ifs-and-or-buts tech podcast, Jason and I are joined by Allison Sheridan and Scholle McFarland to discuss the Apple Watch, loving to hate Microsoft, iPad sales, and Dropbox's new commenting system. Just for kicks, we talk about our favorite non-tech podcasts.
Arrow S3E19-20 Review: "Broken Arrow," "The Fallen"
Speaking of comic-bookery, Guy, John, and I made up for two weeks off by recording a double-header to review the most recent two episodes of Arrow (well, aside from the one that aired last night). We talked about surprising death(s), steamy romance, and our complex feelings about Ray Palmer.
Daredevil Rewind: Episodes 4-6
I've been tearing through Daredevil, and thus was absolutely thrilled to be invited to discuss episodes 4-6 of the series with Moze of the Flash Flaschast and my good pal Merlin Mann. They encouraged me to burn through the next several episodes, and now I only have two episodes left in the season. Those bastards.
Art and design by Serenity Caldwell


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Even with the previous paragragh that states I want to learn to golf? I will do that, but I figured with the previous conversation it would be understood that I wasn't referring to sex.
Even with the previous paragragh that states I want to learn to golf? I will do that, but I figured with the previous conversation it would be understood that I wasn't referring to sex.
I agree with the previous comments on the "try new things" section. Also: "My Spotify playlist has quite the range though, but there is a lot of Prince, it's just sexy music." It's not fair, but most people are going to gloss over the words, see "sexy," and not bother reading anything else. Maybe find a different adjective?
I am pretty sure it's just the online thing. People will do or say just about anything when sitting behind a computer screen. Also, there are a lot of freaky older women out there, and not to say I don't have some freaky tendencies I just prefer to know someone before I let them be known. So I am sure the guys who are doing this got the green light previously from some other woman and just thought it was ok with everyone.
You're going to have either commit to a felon or get young dumb dick for a while. Take your choice. Or move out of AZ.
This is a discussion I continually have. What happened to dating or just hanging out if dating is too scary of a word? I do not want a boyfriend or a committment, I just want a cool guy I can stand to be around for more than an hour. That includes conversation, grabbing some beer, shooting pool and sex. Then he can go his way and I can go mine, and maybe we can meet up again in a week. I don't even really need to hear from him in between. What is that relationship called?
YAY Ivy!
Define tall.
You think we wanna talk to you when we know the only reason you call us is to stuff your empty hole? Fuck no. Black ops 2 is out on Tuesday.
You can both come to me and we'll see what happens.
I've had one night stands that wanted to cuddle in the morning. Guhhhhhnothankyou.
5/22: Move D, Reaganz, Sassmouth @ Monarch
5/28: Refused, White Lung @ GAMH
5/29: Spoon @ The Fox Theater, Oakland
5/29: Max Cooper EMERGENCE @ PW
5/30: Neutral Milk Hotel @ Pappy & Harriet's
6/2: Kiasmos ft. Olafur Arnalds, Rival Consoles @ The Independent
6/6: Matthew Dear, Daniel Bortz @ Public Works
6/12: Christian Loeffler @ TBA
6/17: Clap Your Hands Say Yeah @ The Independent
6/21: Underworld, Jungle @ The Hollywood Bowl
6/25: Until the Ribbon Breaks @ The Rickshaw Stop


text:
Student Council Meeting
Date: 7/15/2015, 2 PM – 4 PM
Location: Student Activities Coordinator (C102)
Schedule Pick-up for Last Names L-Z
Date: 7/17/2015, 8:30 AM – 10 AM
Location: Gym
Schedule Pick-up for Last Names A-K
Date: 7/17/2015, 10 AM – 11:30 AM
Location: Gym
ASK Work Day
Date: 7/20/2015, 9 AM – 3 PM
Location: Student Activities Center (C102)
New Student Orientation (grades 10-12 only)
Date: 7/21/2015, 9 AM – 2 PM
Location: Library
ASK Work Day
Date: 7/22/2015, 9 AM – 3 PM
Location: Student Activities Center (C102)
Student Council Meeting
Date: 7/22/2015, 2 PM – 4 PM
Location: Student Activities Coordinator (C102)
First Day for Teachers
Date: 7/23/2015
ASK Work Day
Date: 7/23/2015, 9 AM – 3 PM
Location: Student Activities Center (C102)
Freshman Orientation Facilitator Training
Date: 7/24/2015, 10 AM – 3 PM
Location: Cafeteria
|Show Calendar »
|Show All »
Kalaheo High School is a community of learners where individuals prepare for the challenges and opportunities in a diverse and global society.
It is our mission to prepare students for higher education, future employment and responsible citizenship.
Navy Commander extends duty so daughter can graduate from Kalaheo High school.
Schedule Pick-up--July 16 in the Gym (NEW DATE!)
8:30-10:00am for last names beginning with L-Z
10:00-11:30am for last names beginning with A-K
ASK Summer Calendar
Graduation Information
Mahalo to the dedicated teachers and staff of Kalaheo High School. You are appreciated for your hard work and commitment to helping our students succeed.
May 1 (Fri) Luncheon (from PTSA)
May 4 (Mon) Coffee & Donuts (from PTSA)
May 5 (Tue) Room Service Lunch (From ASK)
May 8 (Fri) Breakfast To Go (From Administration)
PTSA May 2015 Newsletter
Registration for Hybrid Online Learning
Kalaheo PTSA Spring Fling 2015
Spring Fling 2015 will be held on the Kalaheo campus on Friday, May 8 from 4:00 to 8:30 pm. Music from Dread Ashanti, a student dodgeball tournament (from 3-4 pm), silent auction, craft booths, food trucks, bake sale and more! All proceeds benefit the Kalaheo scholarship fund for college bound seniors! Sign up your dodgeball team (6-10 players) with Mr. Lau. $5.00 team entry fee. For booth space, contact firstname.lastname@example.com.
PTSA April 2015 Newsletter
AP Pre-Administration Bubbling Session
Students who PAID to take an AP Exam in May 2015 must attend the AP Pre-Administration Bubbling Session on Wed., April 22 at 1:55 pm in the Kalaheo Library. 166 students are expected to attend this session. Completing the bubbling is required so we don't have to complete it before every AP exam. The sooner you arrive, the sooner we will finish.
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For more information on your privacy rights, the laws that protect them, and how to exercise your rights, contact your school administrator or visit http://ferpa.k12.hi.us