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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
31 year old man | Glendale, CA, USA | Seeking women 23-33 within 25 miles
Green eyes.
I'm that unexpectedly funny person. I gather this, judging from the looks on the faces when people laugh at something I've said. They're surprised. The unexpectedly funny person. Sometimes I catch a glimpse of dance, sculpture, or a certain kind of painting, and I find myself breathless. And I move on to really low brow entertainment, the kind I like, like Shaun of the Dead, and Anchorman. Which is why I work in entertainment. But I'm also drawn into a film like The Tree of Life. I'm an editor, which makes me a patient person, and a storyteller. Ask me about work and dreams, and you'll get definite plans and a history of hard work and fun. I like to appreciate the complexity of the world. I'm passionate about finding the common ground we all share. That, perhaps, makes me a mediator. No my income is not listed. Shame on you for looking. ;) Sitting on the porch with friends talking ridiculously late into the night, eating out, striking up conversations with strangers, taking big steps in life that make me uncomfortable, and the feel of a hand in mine, are all parts of the good life. I'm into the classy girl who lassos the moon in her sky. She values peace, likes to try that untried thing on the menu. She likes being chased down the hall for a kiss, she loves a good hug, a back rub, and a meal from scratch. She is independent, yet wants someone dependable. She is someone who goes out of her way to do thoughtful things for strangers. And if you don't fit that description? Surprise me.
Coffee and conversation , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Religion/Spiritual , Travel/Sightseeing , Wine tasting
Bowling, Running, Skiing, VolleyBall, Walking / Hiking
I exercise 3-4 times per week.
I don't believe in astrology
I like Cats, Dogs, Horses
At one time, my family had two dogs, two cats, and a parakeet, and each of them had a voice me and my siblings gave to them. Hooray for anthropomorphized animals!
Middle of the Road
Hugo's, Roscoe's (!), Jone's Coffee, Peet's Coffee, friends' kitchens - places with apostrophes.
Modern Family - laugh every time. Friday Night Lights! Clear eyes, full heart. Anchorman. The Tree of Life.
I love nothing more than to sit over a good meal and talk. Outdoors, art, artists, film and giving = the good life.
The Old Man and the Sea (Ernest Hemingway), and The Gunslinger (Stephen King).
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'9" (175cms)
|4'0" (121cms) to 6'3" (190cms)
|Body type:
|Slender, About average, Curvy, Athletic and toned, Full-figured
|Black, Blue, Brown, Grey, Green, Hazel
|Dark brown
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Salt and pepper, Silver, Dark blonde, Grey, Platinum
|No Way
|Occasionally, Cigar aficionado
|Social Drinker
|Social Drinker, Regularly, Moderately
|Artistic / Creative / Performance
|Administrative / Secretarial, Artistic / Creative / Performance, Executive / Management, Financial / Accounting / Real Estate, Labor / Construction, Legal, Medical / Dental / Veterinary / Fitness, Political / Govt / Civil Service / Military, Retail / Food services, Sales / Marketing, Self-Employed / Entrepreneur, Student, Education / Teacher / Professor, Technical / Science / Computers / Engineering, Travel / Hospitality / Transportation, Other profession, Nonprofit / Volunteer / Activist, Fashion / Model / Beauty, Architecture / Interior design
|I'll tell you later
|No preference
|Never Married
|Never Married, Widow / Widower
|Have kids:
|Wants kids:
|Definitely, Someday
|White / Caucasian
|Asian, Black / African descent, East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian, Other
I am fascinated by other cultures. Travel has taken me to the UK, Romania, Africa, Nepal, and a quick pizza hunt in Milan.
|Christian / Other
|Christian / Catholic, Spiritual but not religious, Christian / Other
God is beautiful.
|English, Other
|High school
|High school


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YIELD: Makes 1 1/2 cups
1. Put on a kettle of water to boil. Cut the onion into very thin slices or a mince and place it in a colander in the sink.
2. In a bowl large enough to comfortably fit all the onion, combine the vinegar, sweetener, and salt and whisk until blended.
3. Pour the boiling water over the onion and shake to drain. (It's fine if a little water still clings.)
4. Add the onion to the vinegar solution and stir to coat. Let it sit for at least an hour or up to several days, covered and refrigerated, occasionally stirring and/or shaking to allow maximum exposure to the liquid. Store in a jar with a tight-fitting lid in the refrigerator.
Optional Enhancements
For beautiful, exotic pickled fruit, add fresh or frozen cherries, blueberries, or raspberries—or some small watermelon chunks—to the onion after the first hour of sitting time * Add any of the following to the pickle mixture: Raw broccoli stems, peeled and cut into slender matchsticks * Raw fennel, cut into thin slices * Lightly steamed carrot slices * Lightly steamed cauliflower, cut into 1-inch florets
Reprinted with permission from Heart of the Plate: Vegetarian Recipes for a New Generation by Mollie Katzen. Copyright © 2013 by Tante Malka; photographs and illustrations © 2013 by Tante Malka. Published by Houghton Mifflin Harcourt.

subset: commoncrawl


text:
2 Reviews
- Most Helpful
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- Highest Rating
This is definitely addictive! I added some basil and oregano-- about a teaspoon each-- and served it with warm flat bread.
Agree with Starrynews - this is addictive. I added fresh thyme, and green onions and few shakes of red pepper flakes. Served with crunchy, french bread fresh from the oven. Divine!


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Category:Musicians from County Dublin
From Wikipedia, the free encyclopedia
This category has the following 2 subcategories, out of 2 total.
- ► Musical groups from County Dublin (1 C, 8 P)
- ► Musicians from Dublin (city) (1 C, 112 P)
Pages in category "Musicians from County Dublin"
The following 68 pages are in this category, out of 68 total. This list may not reflect recent changes (learn more).


text:
Expedia.com offers a selection of 1 hotels in Stagno. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs.
Expedia.com will not only save you time, but also money when booking your stay at a hotel in Stagno. Making reservations so you can stay within your budget is easy with us.
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Go ahead. Enter your travel dates to view the best offers on hotel rooms in Stagno, Italy now!
Looking for local hotels nearby? Check out the new hotels near me page.


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The last day of school before a break is always an exciting time for students, but the day is made even more special when there's a sing-along.
John Patrick Kennedy will become Lakeview Academy's sixth headmaster on July 1.
As seasoned reporters were herded behind the gate from which they would cover U.S. Vice President Joe Biden's speech Thursday in Dawsonville, 10-year-old Andrew Liang joined the ranks.
They weren't sure exactly when he would be passing by, but members of the Democratic Party of Dawson County were ready and waiting to greet U.S. Vice President Joe Biden's motorcade.
Forty years ago, business proprietors carefully gauged a location's access to water, sewer and electricity before setting up shop. Now they want all that plus high-speed Internet service.
Georgia Republican Gov. Sonny Perdue and Democratic U.S. Vice President Joe Biden stood together on at least one issue Thursday - an effort to improve communication and attract industry in North Georgia.
The next speaker of the Georgia House of Representatives drew raves after his election Thursday, with lawmakers saying he should quickly move past the scandals that rocked his predecessor.
FLOWERY BRANCH - Dinah Wayne is stepping down Dec. 31 after nearly 10 years as head of Flowery Branch's Better Hometown program.
Gainesville's City Council discussed ways to revamp the recently disbanded Main Street Gainesville organization at a council meeting Thursday.
Make sure to turn in those overdue library books.
A judge on Thursday sentenced a former Jefferson police captain to a year in prison for having a gun while using crack cocaine, but declined to increase the sentence for a grenade found in the ex-officer's car.
The driver's low blood sugar may have been a contributing factor in a head-on collision Thursday that killed two Flowery Branch residents, according to the Georgia State Patrol.
UPDATE: Georgia's Republican Governor, Sonny Perdue, and Democratic Vice President Joe Biden stood together on at least one issue this morning: an effort to improve communication - and attract industry - in North Georgia.
Republicans in the Georgia House of Representatives are expected to meet at the state Capitol today to choose their leaders for the 2010 session.
Page 1122 of 1628
With big dreams come the possibility of worst nightmares.
One answer to the foster care crisis in Hall County is clear: More foster homes are needed for the approximately 180 children in care each month.
Group homes, despite the name, can be lonely places for teenagers.
Sierra Downs does not remember the beating.
For weeks, a young Tod Peavy had tinkered and toiled and thought of nothing but this car. But his foster mother resented the red roadster. She hadn't given it to him. Instead, a holiday well-wisher purchased the present for an anonymous foster child, and caseworkers put the toy in the boy's hands for Christmas.
Lindsey Shubert dialed the numbers.
Crystal Roughton hitchhiked to get to the Hall County Courthouse on time. After her newborn was taken at the hospital, Roughton had to get her baby back.
When Wendy Boswell said goodbye to her foster daughter last month, she literally ached with grief.
As she talks about the joys of working with foster children, Tyne Jackson can't help crying a little.
The removal of a child often results in three types of trauma, according to Hall County Juvenile Court Judge Lindsay Burton.
At 8:30 a.m., the briefs are organized and the coloring books are gathered. The robe goes on for Hall County Juvenile Court Judge Lindsay Burton.
Foster care is in crisis in Hall County.
Page 9 of 9
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Charlie and...Chocolate Factory (UK - DVD R2)
We have specs for the Warner release of this Tim Buton movie
Starring: Johnny Depp
Released: 21st November 2005
Further Details
Warner Home Video has announced the release of Charlie and the Chocolate Factory for the 21st of November, priced at around £22.99. The two disc set will feature an anamorphic widescreen (1.85:1) transfer and Dolby Digital 5.1 audio. Full specs are listed below, along with the official region two artwork.
- Making-of Featurettes:
—Chocolate Dreams: Learn about Tim Burton's vision for the film and how he adapted the story
—Different Faces, Different Flavours: Meet the actors and learn about the characters they play
—Designer Chocolate: Learn about the film's production design
—Under the Wrapper: Go behind-the-scenes to see how the film's special effects were created
—Sweet Sounds: Watch the creation of the 4 Oompa-Loompa songs by composer Danny Elfman
- Attack of the Squirrels: See how real squirrels were trained to perform in the film
- Fantastic Mr. Dahl: Learn about author Roald Dahl's life story and extraordinary body of work
- Becoming an Oompa-Loompa: See how one actor, Deep Roy, was turned into a multi talented army of Oompas
- DVD Menu Challenges:
—Oompa-Loompa Dance
—The Inventing Machine
—The Bad Nut
—Search For the Golden Ticket
- DVD-ROM (Charlie and the Chocolate Factory PC game demo and web links)
News by Chris Gould
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Please sign ePetition to get Infants Roundabout replaced in Memorial Park
0 Members and 1 Guest are viewing this topic.
This is a long shot really but here goes - Does anyone know anything about the history or have any stories or information relating to a Private Children's Nursing Home in situated Marple, that was in existence in the 1930's & 40's & probably much later too. I'm sorry I don't know what it was called.It may also have had some association / connection with a local MP & during this period (from abt 1938-1945) was run by an Effie Clancy....who may have been of Irish origin?.All help however small much appreciated.Thanks to all and Regards. Annie.


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Archive for the 'Soft Goods' Category
ReebokFriday, March 6th, 2015
Tommy Hilfiger / Winter 2014Monday, December 15th, 2014
Recent work for Tommy Hilfiger US.
Stylist: Bill Laughlin
LI Pulse / December 2014Friday, December 5th, 2014
LI Pulse / September 2014Wednesday, August 27th, 2014
Tommy HilfigerWednesday, June 18th, 2014
Recent work for Tommy Hilfiger US.
Stylist: Bill Laughlin, Julie Morrison
Banana Republic / Men's Spring Outfitting GuideSaturday, May 31st, 2014
We recently had the opportunity to work on the still-life images in Banana Republic's debut Men's Outfitting Guide – check out a few excerpts below.
Stylist: Kate McCann
Mack Weldon / SilverMonday, April 21st, 2014
Truly revolutionary men's undergarments – check out the Mack Weldon Silver line, as well as their other impeccable men's staples.
Stylist: Megan Terry


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This unofficial project ports back most of Sonic Unleashed's day levels from the Xbox 360 version into Sonic Generations on PC. It also includes any improvements that are deemed as necessary to accomodate to the better control scheme, higher resolution graphics, and a much smoother framerate.
No tutorials were found matching the criteria specified. We suggest you try the tutorials list with no filter applied, to browse all available articles. Join now to share tutorials with the community.


text: on Mar 4, 2013 @ 11:52 AMMar 4, 2013 @ 11:52 AM Published URGENT ¥¥¥ 'Qaeda' suicide bomb kills 12 in Yemen: witness, medicsA suicide car bomb driven by a suspected Al-Qaeda militant on Monday rammed into a building in south Yemen used by pro-government militiamen killing 12 of them, a member of the group and medics said."A suicide car bomber from Al-Qaeda managed to reach the office of the Popular Resistance Committees in Loder, and detonated the explosives at the gate," said a member of the militia that have fought the Islamist militants alongside the army."Twelve bodies were brought to the morgue," said a medic at a local hospital. faw/ak/sma


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NATURE | Kangaroo Mob | Metropolitan Marsupials | PBS
Duration: 01:01
Program: Nature #2905
There are thousands of kangaroos living in the hills around Canberra. And as night falls, they start moving into the suburbs. Meet the mob of street-smart kangaroos moving into Australia's capital city and the ecologists who follow their every move. Over the course of one drought-stricken year, follow mob leader, Black Spot, and kangaroo mother, Madge, with her two young joeys — mischievous Sonny and tiny pouch-bound Alice. This is a look at what happens when human development encroaches on wildlife habitat and two very different species are forced to co-exist. "Kangaroo Mob" premieres on PBS Wednesday, January 11, 2012 at 8/7c (check local listings) and is part of the 30th season of the Peabody and Emmy award-winning series produced by Thirteen in association with WNET.ORG for PBS. Major support provided by Canon USA Inc. www.pbs.orgTags:
Nature | Kangaroo Mob | PBS (#2905)
Full Program: The kangaroo population around Australia's capital has exploded to the tens of thousands. 49:39
NATURE | Kangaroo Mob | A New... (#2905)
Trips to the city become less frequent after the rain produces an abundance of grass in the hills. Meet the mob of... 01:15
Nature | Filming Urban Roos | PBS (#2905)
Kangaroo Mob Producer Sally Ingleton on the film and what urban kangaroos can teach us. 02:25
Nature | Metropolitan Marsupials... (#2905)
As night falls, the kangaroos of Canberra start moving into the suburbs. 01:01
Nature | Kangaroo Mob - Preview... (#2905)
Premieres Wednesday, January 11, 2012 at 8:00 p.m. ET/PT. Check your local listings. 00:31
Nature | The Head Roo | PBS (#2905)
Meet Blackspot, the dominant male of a local Canberra kangaroo mob. 01:18
Nature | A New Vitality | PBS (#2905)
Trips to the city become less frequent when there's an abundance of grass in the hills. 01:15
Nature | Cracking the Koala Code... (#2913)
Cracking the Koala Code premieres nationally Wednesday May 16, 2012 at 8/7c on PBS. The film explores the day-to-day... 01:48
Nature | Survivors of the... (#2811)
After bushfires tore through the Australian state of Victoria in February 2009, burned and traumatized survivors... 00:30
NATURE | Attenborough's Life...
In "Life on Camera," Sir David Attenborough revisits key places and events in his wildlife filmmaking career,... 00:33
NATURE | Attenborough's Life...
In "Understanding the Natural World," Sir David Attenborough shares his memories of the scientists and the... 00:32
NATURE | Attenborough's Life...
In "Our Fragile Planet," Sir David Attenborough reflects on the dramatic impact that human beings have had on the... 00:32
NATURE | An Original DUCKumentary... (#3004)
A look at all that's entailed in getting those duck feathers just right. "An Original DUCKumentary" premieres... 01:20
NATURE | An Original DUCKumentary... (#3004)
A newly hatched wood duckling jumps from her high-up tree nest to reach her calling mother. "An Original DUCKumentary"... 01:20
Nature | Animal Odd Couples | PBS (#3003)
Full Program: Love apparently knows no boundaries in the animal kingdom. 53:00
NATURE | Animal Odd Couples |... (#3003)
After being abandoned by her mother, a baby fawn, Pippin, was adopted by a Great Dane, Kate, and they have been best... 01:04
NATURE | Animal Odd Couples | The... (#3003)
Primatologist and evolutionary biologist Dr. Lauren Brent discusses her research on the social behavior of nonhuman... 01:41
NATURE | Animal Odd Couples | The... (#3003)
A 45-year-old female Aldabra tortoise was chosen by an unlikely suitor: a male Pacific Brant goose. An... 01:12
NATURE | Magic of the Snowy Owl... (#3002)
In the dim glow of the Arctic glow, the true majesty of the snowy owl can be seen in its frozen, white kingdom.... 01:05
- Watch more video from this program
Post Date: January 10, 2012


text: Murphy Nick Murphy, Nick. FremantleMedia. British Broadcasting Corporation. en 67293687 2006 Story of one Video recordings for the hearing impaired A humor-inflected history of the of the number one, covering military applications in ancient Rome, the measurement of distances in India, and the decimal system created by Leibnitz. The birth of 1 -- 1 gets civilized -- 1 becomes the ruler -- 1 becomes a Greek god -- 1 joins the army -- 1 the enlightened -- 1 goes west -- 1 takes on Europe -- 1 & 0 go it alone. History The story of 1 Full screen. vau PBS Home Video. Unwin Ty Unwin, Ty. Numerals. Numeration--History. 9780793692095 0793692091 Jones Terry Jones, Terry, 1942- 1942 Norrey Peter Norrey, Peter. Ereira Alan Ereira, Alan. Du Sautoy Marcus Du Sautoy, Marcus. Numerals--History. One (The number) c2006 Alexandria, Va.? 9780793692088 0793692083 James Jasper James, Jasper. Kemp Adam Kemp, Adam. Hartley Chris Hartley, Chris. PBS Home Video Impossible Pictures. Public Broadcasting Service (U.S.) Educational films. Jellyfish Productions. One (The number)--History. Numeration.


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Telephone & Addresses
(1 - 4 from 120
Colin Quinn, Chapel Hill, US, Manning Dr
View Colin's social profiles and photos on Facebook, MySpace, and +40 Networks.
Colin Quinn, Exton, US, Heritage Ln
View Colin's social profiles and photos on Facebook, MySpace, and +40 Networks.
Colin Quinn, Libertyville, US, Mckinley Ave
View Colin's social profiles and photos on Facebook, MySpace, and +40 Networks.
Colin Quinn
23456 Virginia Beach VA
Yellow Page contacts
Network Profiles
(1 - 4 from 169
MySpace Profile: colin quinn (159308074)
Scranton, PA
(1 - 4 from 22
Get Out this Weekend
03.03.2011 [Patch.com] - He has demonstrated his quick wit and skewed vision of the world on the" Opie and Anthony" radio show and on TV's "Tough Crowd with Colin Quinn." Where/When: At the Community Theatre in Morristown at 8 pm on Friday, March 4. Why Go: Because Ebersole is
Colin Quinn Explains Why Every Time Comedy Gets Cool, It's Bad ...
when he used to live across the street in a one-room apartment ...
Colin Quinn -- Beware Drunk Comedians ... Sleeping in Traffic (TMZ ...
. Some of the details are kinda fuzzy ... which makes sense…
Colin Quinn's Long Story Short Set for April 9 Premiere on HBO
04.03.2011 [TheaterMania.com] - HBO's previously reported special of Colin Quinn's one-man show Long Story Short, which will end its Broadway engagement at the Helen Hayes Theatre on March 5, will air on the network on April 9 at 10pm (ET). Jerry Seinfeld has directed the production.
Business Profiles
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Researchgate: Colin Quinn
Colorado, United States
Private Homepages
(1 - 4 from 7
Colin Quinn Long Story Short || Directed by Jerry Seinfeld
Official Site. Colin Quinn on Broadway in Long Story Short, directed by Jerry Seinfeld. Limited Engagement, Now Playing on Broadway.
The Show
Colin Quinn returns to the stage in UNCONSTITUTIONAL where he tackles 226 years of American Constitutional calamities in 70 minutes. On May 25th, 1787, fifty-five ...
Colin Quinn Unconstitutional | Cherry Lane Theatre, NYC
Colin Quinn Unconstitutional
The Tour!
Click on the city to buy tickets! June. June 13 – July 6 Philadelphia, PA August. 23rd – Belleayre Music Festival – Highmount, NY
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ratemyteachers: Colin Quinn
Madison Heights, MI, Wilkinson Middle School
ratemyteachers: Colin Quinn
Saratoga Springs, NY, Saratoga Springs High School
ratemyteachers: Colin Quinn
Troy, MI, Baker Middle School
classmates: Colin Quinn
South Windsor High School, South Windsor, CT, 1994-1998
Celebrities & Politicians
(1 - 2 from 16
IMDB Filmography: Colin Quinn
Actor, Saturday Night Live
Bad news
findagrave: Quinn, Colin C
12/18/1906 - 06/20/1983, Lebanon (Bradley County, Tennessee)
Blathnaid And Colin Quinn And Wood : Engagement : Scotsman...
Engagement announcements for "Blathnaid Colin Quinn" in the Announcements. Wedding Bells announcements for "Blathnaid Colin Quinn" in the Announcements ...
Books & Literature
Colin Quinn - AbeBooks
Universities and Industrial Research by Ewald Konecny, Colin Quinn, Kurt Sachs, David Thompson and a great selection of similar Used, New and Collectible Books...
Colin Quinn Quotes - BrainyQuote
Enjoy the best Colin Quinn Quotes at BrainyQuote. Quotations by Colin Quinn, American Comedian, Born June 6, 1959. Share with your friends.
Colin Quinn | Official Publisher Page | Simon & Schuster
Colin Quinn on Simon & Schuster - Happy Endings
iTunes - Movies - Colin Quinn: Long Story Short
Long Story Short directed by John Moffitt for $7.99.
Related Documents
Colin Quinn | University of Michigan - Academia.edu
Studies Bronze Age Europe (Archaeology), Early Bronze Age (Archaeology), and ...
Video & Audio
(1 - 4 from 47
Collin Quinn - Long Story Short - 1 of 6 - stand-up - YouTube
1 year ago. I love you Colin Quinn, but I found LONG STORY SHORT on youtube. ..HBO doesnt ...
Watch SNL40: Chevy Chase Tribute From Saturday Night Live ...
Kevin Nealon, Norm Macdonald, Seth Meyers and Colin Quinn pay tribute to the Weekend ...
BlinkX Video: Beware! Colin Quinn is on the Loose
The former "SNL" star dishes about his adventures in comedy. - 05.05.2008, ABCNews
BlinkX Video: Jerry Seinfeld Directs Colin Quinn Behind the Scenes in Long Story Short on Broadway
Our cameras were given an exclusive peak inside the technical rehearsal for Colin Quinn's Long Story Short on Broadway directed by Jerry Seinfeld! Long Story Short is on Broadway... - 10.22.2010, YouTube
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TV best bets: Sat., March 19
19.03.2011 [NorthJersey.com] - Co-stars include Salma Hayek, Maria Bello, Steve Buscemi and Colin Quinn. 7 pm, SYFY CHANNEL: Population 436 — Refreshingly short on gore but long on chills, this 2006 suspense tale has a definite "Twilight Zone" feel to it.
'Give It Up For Greg Giraldo': Remembering A Legend
18.03.2011 [Huffington Post (satire)] - Or maybe you remember him as one of the quick-witted yet high-minded panelists on "Tough Crowd with Colin Quinn." Greg was loved and admired by fans and his peers alike, and his loss has been felt by both in equal measure. Which is why Comedy Central
Google News: Iconic photograph tells cautionary tale at AXA Art Lounge at AIPAD, New York
17.03.2011 [ArtfixDaily (blog)] - Colin Quinn, Claims Director at AXA Art noted, "As an art insurer we understand that accidents do happen, that's why we are in business. However, using adequate packing and crating materials would have helped to avert this incident", Quinn concluded.
Daily guide
17.03.2011 [Boston Globe] - A St. Patrick's Day dish with comedian Colin Quinn. The View at 11 am on Chs. 5, 6, and 9. Steve Martin performs on a St. Patrick's Day-themed show. Afternoon Tyra Show at 3 pm on Ch. 56. Parental responsibility for childhood obesity.
Reports & Statements
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Twitter Posts: DooderDirtyMoney (JoeDooder)
20.03.2011 Colin Quinn and Dave Attell (@ Comedy Cellar w/ 2 others) http://4sq.com/eIImLX
colin quinn on Tumblr
https://www.tumblr.com/tagged/colin-quinn Cached Find and follow posts tagged colin quinn on Tumblr.
Colin Quinn - Reddit
2: Redux, Long Story Short and every living comics act. Colin's Twitter · Colin's ...
Twitter Posts: Nick Lynch (NickLComedy)
20.03.2011 Watching colin quinn's hbo special. Love the mullet & the pirates jacket http://twitpic.com/4b87lr
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Colin Quinn GIFs on Giphy
animated GIF colin quinn, daily show, hank azaria, john oliver, mark leibovich #colin ...
Colin Quinn Unconstitutional / The Grand Wilmington
smoky-voiced stand-up comic Colin Quinn brings his newest one-man show, ...
Colin Quinn on 40th Anniversary of SNL | WGN Radio - 720 AM
Anniversary of SNL. ... Comedian Colin Quinn on Seinfeld and SNL.
Colin Quinn tickets - Colin Quinn Tour Dates on StubHub!
Tour Dates on StubHub! Buy your Colin Quinn ticket today.
Premiere Party With Jerry Seinfeld and Colin Quinn | The Creative ...
Colin Quinn, and Brian Stern will host the premiere and party for ...
Watch Colin Quinn: Long Story Short Online Free Putlocker ...
Colin Quinn performs his one-man show about world history, which he originally ...
Colin Quinn - Starpulse.com
www.starpulse.com/Actors/Quinn,_Colin/ Cached Similar Colin Quinn Pictures, Biography, Movies & TV Shows, Videos.
136. Colin Quinn - 'Saturday Night Live': All 141 Cast Members ...
hang out and be himself, yet.
APA - Comedy > Colin Quinn
his stand-up career in New York as a regular on the comedy club circuit. He made ...
ATTPAC | Colin Quinn Unconstitutional Live at the Wyly Theatre
Dallas. ATTPAC.org is the only official online ticket outlet for the ...
Amy Schumer plays a hipster drug dealer in Colin Quinn's 'Cop Show'
Wednesday and it features Amy Schumer, comedy's saltiest ...
Colin Quinn - Martha Stewart
and how to's from Martha Stewart.
Colin Quinn Joins Amy Schumer, Bill Hader in Judd Apatow's ...
Schumer in Judd Apatow's next Universal Pictures comedy ...
Colin Quinn Returns to Westhampton Beach - Dan's Papers
Arts Center, where he will perform an early draft of "Once Upon ...
Colin Quinn Tickets at LaughStub.com : LaughStub
his five years in the cast of Saturday Night Live, as the sidekick/announcer of ...
Colin Quinn Tickets | Event Dates & Schedule | Ticketmaster.com
schedule, reviews and photos.
Colin Quinn Unconstitutional - Marcus Center for the Performing Arts
years of American Constitutional calamities in 70 minutes.
Colin Quinn Unconstitutional | Philadelphia Theatre Company
years of American Constitutional calamities in 70 minutes. On May 25th, 1787, ...
Colin Quinn has some Thanksgiving tips for his adoring fans | Twitchy
Thanksgiving for his loving followers. They really appreciated it.
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Incomprehensible Horror: A Nearly Unbearable Video From The Producer Of The Gosnell Movie
This is a new video released today showing Ann McElhinney (Producer, Gosnell Movie) reading an extract from the Grand Jury report on the crimes of the abortion doctor Kermit Gosnell.Warning: What you are about to see is extremely disturbing. What you are about to hear is a terrible truth about America's most heinous and prolific serial killer. This video is very upsetting.That was read from | Read More »


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Email this article from PlasticsNews.com
CPIA studies plastics-to-fuel process
MISSISSAUGA, ONTARIO — Burning plastics for fuel is occasionally posited as an untapped resource. Now a study carried out for the Canadian Plastics Industry Association has put some numbers to such a proposal.
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Office Star Products Screen Mid-Back Office Chair with Arms
Office Star Products Screen Mid-Back Office Chair with Arms
Additional Documents
Weights & Dimensions
Adjustable Seat Height
Additional Weights & Dimensions
|Product Type: Task chairs
|Style: Contemporary
|Base Material: Metal
|Exterior Seat Material: Leather
|Back Height: Mid-back
|Adjustable Height: Yes
|Tilt Control: Yes
|Casters: Yes
|Heated Seat: No
|Armed: Yes
|Country of Manufacture: China
|Assembly Required: Yes
|GSA Approved: No
About the ManufacturerOffice Star manufactures a large variety of products, featuring comfortable and utilitarian office seating. With a lot of color and style options to choose from, Office Star is guaranteed to enhance the functionality and comfort of your office environment.
All styles and models of Office Star chairs are available at Wayfair.
Office Star Products Screen Mid-Back Office Chair with Arms
Questions & Answers (2)
"Hi, do you have the mesh seat material available for this chair?" asked by Albert
"Hi, what is the weight limit of the chair?" asked by Tony
Still have questions about this product? We're here to help
Customer Reviews
|5 star
|4 star
|3 star
|2 star
|1 star
Great buy!
Hugo from Calexico, CA – Verified Buyer
I ordered three chairs by phone because I needed assistance. The operator that answered me was courteous, professional and very helpful to quickly assist and answer my questions and place my order. The items were shipped that same day and arrived on time in the promised time. The chair was very easy to assemble, it took me about 15 minutes to do so by myself. Product seems very high quality and sturdy, it appears that I will last for a long time. Time will tell. In the meantime I'm very happy with the whole transaction from start to finish. I definitely recommend the store and this product.
Call Center with 50+ employees. Excellent Chair!
James from Sanford, FL – Verified Buyer
I searched over the web for many hours for many days looking for the right chair. Based on some of the reviews I was skeptical of this chair. I only order 5 at first to see what the product was. Very sturdy chair with great support and every employee that received it was very grateful. I purchased another 20 within 30 days. Easy to assemble, in fact we assembled each chair within 10 minutes from opening the box. It has now been 4-5 months and I am ordering more. I recommend this chair for any office looking for an affordable chair that is built like a much more expensive chair.
Amazing value fr my small offce
Benjamin from Morton, IL – Verified Buyer
Should have bought new desk chairs from Wayfair years ago. The quality of this chair is incredible and putting together was a breeze. I would most certainly recommend this chair. And thank you Wayfair for good old fashion customer service!
Excellent for price
Sherry from Wesley Chapel, FL – Verified Buyer– Top 100 Reviewer
I have purchased hundreds of these chairs for offices I decorate. Everyone loves the chair. The back reclines and has an adjustable lumbar. Firm seat so you don't feel like you are slipping down into a chair. Easy to put together, about 10 minutes. Highly recommend.
You will not be disappointed in this chair.
M. from Sebring, FL – Verified Buyer
Good support with the high mesh back. The only thing I wish it could do is have the seat tilt a small amount. I prefer my knees a little raised (or my bottom a little lower). As far as everything else, you cannot go wrong in my opinion.
Great Chair
William from modesto, CA – Verified Buyer
Great Chair. Assembly is easy. I ordered 2. One had a whole in the mesh back but Wayfair responded immediately and are sending another back piece. The chair is very sturdy and comfortable.
Very Comfortable!
Kyra from Nashville, TN – Verified Buyer
Very comfortable and sturdy. This is a heavily used office and wanted something high quality but affordable. This definitely did both.
Happy Happy Happy
Karen from Shrewsbury, MA – Verified Buyer
You can't beat them for the price. I'm sure there's better chairs out there If we wanted to spend 7 or 8 times as much. We purchased 15 of them and daily someone thanks me and let's me know how much they enjoy there new chair
Great Chair
Jeanette from Thousand Oaks, CA – Verified Buyer
This chair is very comfortable, has adjustable arms and seat.
Great chair...
Marc from Fort Myers, FL – Verified Buyer
I ordered 112 of these. They are a great product, durable and priced very well...
OUR SKU # OT1594Screen Mid-Back Office Chair with Arms is also sometimes listed under the following manufacturer numbers: 583814


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Vic Spencer
Album: The Cost of Victory
As Biggie taught us, "Mo Money" inevitably leads to "Mo Problems." But The Cost of Victory hasn't diminished Windy City rhymesayer Vic Spencer's determination to hustle his way to the top. As the latest step in... More
Posted about 5 months ago
Song: Relapse
Album: The Cost of Victory
Just one short day after blessing our front page with Crown, Vic Spencer is back on our front page with another brand new record off his soon-to-drop full-length. On Relapse, the Chi-Town repper and freestyle series alum... More
Posted about 5 months ago
Song: Crown
With Vic Spencer's next street album less than 48 hours away from release, fans are likely feeling as giddy and restless as kids on Christmas Eve. Mercifully, the Chi-Town phenom and freestyle alum has decided to tide... More
Posted 5 months ago
Song: Early
Rap is full of songs about staying out all night, but where are all the dope records about getting up Early? With his latest promo single, Vic Spencer does his part to fill that neglected niche, waxing poetic about the... More
Posted 5 months ago
Artist: A-Hi
Featuring: Vic Spencer
Song: Oh My
One month after blessing our front page with Know the Name, A-Hi returns with a follow-up single that'll make you go "Oh My!" That is, if you happen to be my grandmother; the rest of y'all will probably say... More
Posted 8 months ago
Song: 24k Visuals
Fresh off celebrating his 33rd birthday with the reader-acclaimed Toxic Waste, Chi-Town phenom Vic Spencer is back on our front page with another fresh promo single. After its jazzy, off-the-cuff intro, 24k Visuals takes a... More
Posted about 9 months ago
Song: Toxic Waste
Hey, Booth readers, what did you get Vic Spencer for his birthday? Nothing? Yeah, me too—in fact I didn't even realize he was turning 33 today. Want to feel even more guilty? Well, the Chicago buzzmaker's been... More
Posted 9 months ago
Song: Real N**as
Currently, Vic Spencer is hard at work on VicTree, a collaborative full-length with fellow Windy City repper Tree. Since that project needs a little more time in the oven, the SAVEMONEY affiliate and DJBooth Freestyle Series... More
Posted 10 months ago
Song: Daily Bread
While it isn't the end all be all, money does make the world go 'round. If someone were to tell you that they wouldn't want more money, they are probably lying. Like virtually every rapper in the game Vic... More
Posted one year ago
Song: Victor
Oft imitated but never equaled, the DJBooth Freestyle Series ran from February 2009 through June 2011. Its 250 total entries were the work of a veritable who's-who of underground and emerging emcees, including rising... More
Posted one year ago
Sample Text - Sample Link


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Beyond Band of BrothersPenguin Publishing Group 2006; US$ 16.00
"There is a saying that 'Great leaders are born not made.' Such a man is Dick Winters... A beautifully written book about a truly great leader. This riveting read clearly reflects Dick Winters's solid character, great integrity, and unerring judgment in critical battlefield situations." ? Lieutenant General Harold G. Moore , co-author of We Were Soldiers... more...
The American Civil WarKnopf Doubleday Publishing Group 2009; US$ 16.95
The greatest military historian of our time gives a peerless account of America?s most bloody, wrenching, and eternally fascinating war. In this long-awaited history, John Keegan shares his original and perceptive insights into the psychology, ideology, demographics, and economics of the American Civil War. Illuminated by Keegan?s knowledge of military... more...
The Civil War: A NarrativeKnopf Doubleday Publishing Group 2011; US$ 26.00
Focused on the pivotal year of 1863, the second volume of Shelby Foote?s masterful narrative history brings to life some of the most dramatic and important moments in the Civil War, including the Battle of Gettysburg and Grant?s Vicksburg campaign. � ?Foote has an acute sense of the relative importance of events and a novelist?s skill in directing... more...
The Civil War: A NarrativeKnopf Doubleday Publishing Group 2011; US$ 26.00
Shelby Foote was born on November 7, 1916 in Greenville, Mississippi, and attended school there until he entered the University of North Carolina. During World War II he served as a captain of field artillery but never saw combat. After World War II he worked briefly for the Associated Press in their New York bureau. In 1953 he moved to Memphis, where... more...
The Presidents ClubSimon & Schuster 2012; US$ 18.00
The Presidents Club, established at Dwight Eisenhower?s inauguration by Harry Truman and Herbert Hoover, is a complicated place: its members are bound forever by the experience of the Oval Office and yet are eternal rivals for history?s favor. Among their secrets: How Jack Kennedy tried to blame Ike for the Bay of Pigs. How Ike quietly helped Reagan... more...
Stalking the VietcongRandom House Publishing Group 2012; US$ 7.99
In a gripping memoir that reads like a spy novel, one man recounts his personal experience with Operation Phoenix, the program created to destroy the Vietcong?s shadow government, which thrived in the rural communities of South Vietnam. Stuart A. Herrington was an American intelligence advisor assigned to root out the enemy in the Hau Nghia province.... more...
Slavery And FreedomKnopf Doubleday Publishing Group 2013; US$ 22.95
This pathbreaking interpretation of the slaveholding South begins with the insight that slavery and freedom were not mutually exclusive but were intertwined in every dimension of life in the South. James Oakes traces the implications of this insight for relations between masters and slaves, slaveholders and non-slaveholders, and for the rise of a racist... more...
Command and ControlPenguin Publishing Group 2013; US$ 18.00
The New Yorker ?Excellent... hair-raising ... Command and Control is how nonfiction should be written.? (Louis Menand) Famed investigative journalist Eric Schlosser digs deep to uncover secrets about the management of America?s nuclear arsenal. A ground-breaking account of accidents, near-misses, extraordinary heroism, and technological breakthroughs,... more...
If This Is A WomanLittle, Brown Book Group 2015; US$ 22.76
On a sunny morning in May 1939 a phalanx of 800 women - housewives, doctors, opera singers, politicians, prostitutes - were marched through the woods fifty miles north of Berlin, driven on past a shining lake, then herded through giant gates. Whipping and kicking them were scores of German women guards. Their destination was Ravensbr�ck, a concentration... more...
The Greatest GenerationRandom House Publishing Group 2000; US$ 17.00
"In the spring of 1984, I went to the northwest of France, to Normandy, to prepare an NBC documentary on the fortieth anniversary of D-Day, the massive and daring Allied invasion of Europe that marked the beginning of the end of Adolf Hitler's Third Reich. There, I underwent a life-changing experience. As I walked the beaches with the American veterans... more...


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A Manteca woman was near the Marketplace Cinema 10 when she was taken out into the country and sexually assaulted before being brought back into downtown Manteca and ordered to withdraw funds from her bank's ATM.
Timothy Uecker, 28, of Manteca was identified by Manteca Police spokesman Rex Osborn as Wednesday night's shooting victim.
A Wednesday afternoon probation search in the 1500 block of Langum Way by Manteca narcotics officers and probation agents yielded two men who are now facing drug charges, Manteca Police said.
Manteca Police are investigating the explosion of a homemade explosive device on Tuesday at 10:15 p.m., in a Central Manteca neighborhood.
An 18-year-old former Manteca resident suspected in a knife attack on a JC Penney loss prevention agent during a shoplifting incident Wednesday was arrested before being able to flee San Joaquin County on a Greyhound bus.
A 17-year-old boy has been arrested by Manteca Police in connection with a carjacking last month.
A plea deal is sending illegal alien Jose Luis Ayala, 21, to prison for almost seven years for trying to run over a Manteca Police officer.
Multiple stab wounds proved fatal to a 35-year-old Manteca woman as she ran from her family apartment – chased by her husband – into a neighbor's front yard in the predawn hours Thursday.
Three law enforcement agencies joined forces Thursday morning to thwart the cashing of lottery tickets in Manteca stolen from the Super Liquor Store in Modesto.
A quick response by Manteca Police officers Armen Avakian and April Pliler cut off fleeing burglars from a home in the 1600 block of Goldpoppy Monday morning in the southwest portion of the city.
A stolen car taken from Elk Grove slammed into a home at the corner of Junction Drive and Daniels Street Friday morning.
Manteca Police Chief Dave Bricker isn't dancing around the issue – he wants Club Leon's dance hall permit denied.
Eight cars were reported stolen late Tuesday and into Wednesday morning – one that was being warmed up while the owner went back into the residence to get a cup of coffee, police said.
One of the 12 defendants charged with conspiracy and other crimes in the federal racketeering case involving the Road Dog Cycle shop, has pleaded guilty.
A 19-year-old driver was shot while driving south on the East Highway 99 Frontage Road early Saturday morning north of Lathrop Road.
Page 66 of 74
VACAVILLE (AP) - California inmates are dying of drug overdoses at nearly triple the national rate and it's unclear whether the tough steps state officials took this year to stop illicit drugs from getting into prisons are having any effect, though they are prompting criticism from civil rights advocates.
FRIENDSHIP, N.Y. (AP) - Investigators tracking two murder convicts who escaped from a northern New York prison scoured a rural area near the Pennsylvania border Sunday, saying an unconfirmed but credible report of a sighting had shifted the search across the state.
A Manteca man was arrested via a citizen's arrest and cited by Manteca Police for allegedly performing a sex act in his truck at the Save-Mart parking lot in the 1100 block of North Main Street shortly after 9 a.m. Friday.
The following are major incidents handled recently by Manteca Police:
Manteca Police have taken $30,000 worth of illegal drugs off the street.
The suspect's bail in Thursday's road rage incident on Highway 99 has been increased to $1,205,375 due to hospital reports that the victim sustained brain injuries and possible paralysis.
Witnesses say a man - who the CHP said has already been convicted of reckless driving - deliberately forced another driver off Highway 99 causing major injuries to the victim in what officers are calling a case of road rage.
The following is a summary of the significant events the Manteca Police Department handled during the past week:
Serious crime continues to drop in Manteca.
Fence boards exploded in every direction in a Grant Avenue alley near Sutter Street at 5:20 a.m. Friday when the driver of a late model Hyundai allegedly ran down a 20-year-old man on foot behind his home and crashed through rear fences in three back yards.
Some $50,000 in small to half-grown marijuana plants were discovered in a Lathrop home Wednesday by police.
Page 1 of 1
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Redwood Property Management
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Phone Number: (360) 664-6488
Business ManagementMr. William Osteen, President/CEO Mr. Richard Gray, Purchase Director Ms. Valerie Rubel, Account Manager Mr. Daniel Williams
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799 Views 2 Replies Latest reply: Dec 24, 2008 11:49 AM by gbullman
direwolf8 Dec 24, 2008 11:37 AM
Re: Can I use Windows Solitaire on new iMac? in response to sunny330 SolvedIf you want to run Windows programs you need to run Windows on your Mac. If it's an Intel based Mac, you can do that with VMware Fusion, Bootcamp, or Parallels. I like VMware Fusion for its flexibility and the different guest OS's it supports.
gbullman Dec 24, 2008 11:49 AM
Re: Can I use Windows Solitaire on new iMac? in response to sunny330 HelpfulYou might want to try Allgood Solitaire, I have been using it for years as my replacement for Windows Solitaire & Free Cell, not to mention Spider and a number of other Solitaire games. Klondike with 1 or 3 cards is pretty much what you're looking for as a replacement.
As was said in the previous post you would need to run Windows on your Mac via 1 of the 3 methods mentioned. If Solitaire is your only missing Windows need going that route would be way overkill.
Good Luck.


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No matter whether you hear him called -- "George Cambridge," "George Wales" or "George Mountbatten-Windsor" -- the closest thing to a statutory surname that our new little prince will have will be "Windsor."
To address when I commented -- with deliberate irony -- how "brilliant a royal Kate is" [for having a boy], perhaps I should share the historical context that some appear to have missed, where many a royal wife suffered at the hands of her husband for not producing a male heir.
In this age of 24-7 paparazzi shots, most high profile new mothers hide out until they get their figures back into photo ready mode. But Middleton didn't do that, instead showing what a real mother's body looks like immediately after birth.
Royal Prince babies and Weiners! It has been one heck of a week. Who knew things would be so eventful. I don't understand Anthony Weiner though... how can you just keep messin' up like that?
Harry's role in this young family's life is an important and unique aspect of the bond that has developed between William and Harry. This, in turn, can also inform our understanding of sibling relationships in general.
How did we get to this ridiculous place, where losing the baby weight is a competitive sport followed by millions?
You may feel your children have nothing in common with the newborn Prince, but they share something with every other child on this planet.
It's not that I am not happy for Will and Kate -- I suppose that I am, as I would be for any couple giving birth to a healthy baby. However, I simply couldn't watch all the media coverage, as it brought up all the pain, time and energy I spent in pursuit of my own baby bump, birth and baby.
But seriously ya'll, I truly believe that if Jesus came back today, he would probably be holding his face in his hands in utter disbelief. In fact, I'd even bet that he'd opt for a name change.
To help the royal family sort through the long list of potential "wannabe princesses," here is a cheat sheet of play-date-worthy tots and those to avoid on the playground.
But the American media obsession with the British monarchy, and the line of succession, is appalling. I mean, really: Who cares who'll be king? This isn't Game of Thrones (unfortunately).
In the spirit of continuing to blend tradition and her own thoroughly modern mark on the royal family, this is my official royal request for Kate to add blogger to her title.
Most of the world is joyously welcoming the arrival of the Prince of Cambridge. And while I find myself caught up in the excitement, what would give me real cause for celebration is if Kate does the very ordinary but extraordinarily important motherly act of breastfeeding her baby.
More hot weather is in store for the little prince -- and every other kid born into this generation. By the middle of this century, according to Greater London Authority, most summers in London will be as hot as the city's epic heat wave of 2003, which killed an estimated 600 people.
This week The Duke and Duchess of Cambridge join millions of parents in the latter phase of parenting, one which will necessitate very active roles in ensuring their child fulfills their personal hopes as well as the hopes of an entire country and world... no small task for certain.
The original William & Kate is basically the Sharknado of rom-coms. It's so bad, with a touch of nonsensicalness, that you can't help but have a soft spot in your heart for it.


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Celebration of Nurses - HealthSource Magazine Hula in the City
- Health & Wellness
- 4160 Boulevard Center Drive, Jacksonville, FL, 32207
Stars Flashin' with Passion for Fashion / Battle of the Fashion Designers
Saturday, January 26, 2013 from 7:00 PM to 9:00 PM (EST)
SFwPF Battle of the Fashion Designers will soon begin this Saturday, January 26, 2013 at FCTC 2980 Collins Avenue St. Augustine, Florida 32084.
Who's Knockin' Entertainment is a production company founded in 2008. Our mission is to Empower, Encourage and Enrich talented individuals, artists, and our communities as a whole with powerful inspirational entertainment, products, and venues that enhances personal growth and enable people to overcome life's struggles.
Stars Flashin' with Fashion is a seasonal production with a game show aspect to it that recognize emerging designers, models, hair stylists and make-up artists who will have the opportunity to battle on the catwalk and compete to determine who will end the season as WK's top designer, model, hair stylist and make up artists. Stars Flashin' with Fashion will be pitched to various network and internet channels. We are looking for sponsors to help make this one of a kind show a great success!
For more information contact Dominique Robinson:
PO Box 4260 * Saint Augustine, Florida 32085
Phone: 904-325-1530
Email: email@example.com
Website: www.wkentertainment.biz
Join millions of people on Eventbrite.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Originally produced for military use, the Volkswagen Type 181 or also know as the Volkswagen "Thing" quickly became the affordable and reliable go-to-... More
TRIPLE WHITE, LOW MILES, BEAUTIFUL DRIVER READY FOR THE ROAD! This is a 2-owner VW with original low miles. Well maintained, original interior and... More
1971 Volkswagen Beetle Good ConditionCould use a little workTrue Import ClassicRear ViewNeeds a new homeAM FM RadioMotivated SellerTitle In HandUnit is located in Las... More
1974 VW Thing very nice orginial condition yellow orignial paint black interior-- comes with Bimini Top and orginal wheels trans 4 speed manual Jeffco Ent -- 2111 E... More
Gateway Classic Cars St. Louis is proud to offer a beautifully restored 1970 Volkswagen Beetle Convertible. This little red bug has just undergone... More
Solid rust free body/pan. runs and drives great. New radial tires. Hard top AND soft top Contact Dave with any questions. 614.519.1853 ... More
Have a look at this nice 1974 Volkswagen "Sun Bug" Super Beetle Convertible which only 300 were produced for 1974. This Bug is powered... More
Volkswagen T2A Westfalia camper 1972 runs and drives 1972 VW T2A Westfalia camper. This camper runs well and needs some cosmetic works. Car has 1584... More
Up for sale in our Tampa showroom is this beautiful and incredibly fun to drive 1977 Volkswagen Beetle. Legendary for their ease of driving... More
For sale in our St. Louis showroom is a great example of classic 1973 Volkswagen Super Beetle. This Super Beetle is powered by a... More
1973 Volkswagen Buggy for sale in our Fort Lauderdale Showroom. This thing is ready for fun in the sun with its 1915 CC 4... More
For sale in our St. Louis showroom is an iconic 1971 Volkswagen Bus Westfalia Westy Camper. Nothing embodies the spirit of the late 1960s... More
For sale in our Fort Lauderdale showroom is a rare triple white 1976 Volkswagen Super Beetle Convertible. During 1976 a worldwide demand started to... More
1978 Volkswagen Transporter Type IIPRICE RECENTLY REDUCED!!!!1978 TRANSPORTER RIVIERA hard top bus camper150 K milesVery well maintainedAll tune-ups----Syntec oil changed every 3-4KRUNS STRONGNearly all... More
NEVADA CLASSIC CAR DEALER #40339 , VIN # 1172087777 Here's one for the ladies, or anyone who craves PINK or needs an attention getting vehicle for your business... More


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Joined: Jun 2013
Oddometer: 26
hi noah
i know you probably don't care but your adventure made me buy a 690 too last day.
you proofed to me the high reliability and capabilities of this bike!
keep rocking the world
Gnarly Adventurer
Joined: Feb 2012
Location: Placer County, California
Oddometer: 497
I am only about half the way through your RR, but am loving it so far!
Beastly Adventurer
Joined: Sep 2012
Location: UK for now.
Oddometer: 1,576
Joined: May 2010
Location: In the mountains?
Oddometer: 1,695
Noah 08 KTM 690 ADV. 125,000 km. 42 countries. 5 continents and counting.
RTW Ride Report --> http://advrider.com/forums/showthread.php?t=781893
Blog ------------------> http://rtwwithnoah.blogspot.com/
Facebook------------> https://www.facebook.com/RtwWithNoah
ignore list
Joined: Jan 2006
Location: Atlanta
Oddometer: 7,607
Where are you at right now, Noah?? Looking forward to the days ahead.
Joined: May 2010
Location: In the mountains?
Oddometer: 1,695
I'm on Sakhalin right now. In a bikers club in Yuzhno-Sakhalinsk. I'm waiting for my motor to cool down so I can do a valve check. I also have to install some blinkers that came off somewhere in Mongolia.. or Siberia.. I don't remember. I think the next ferry to Japan is on the 10th.
Noah 08 KTM 690 ADV. 125,000 km. 42 countries. 5 continents and counting.
RTW Ride Report --> http://advrider.com/forums/showthread.php?t=781893
Blog ------------------> http://rtwwithnoah.blogspot.com/
Facebook------------> https://www.facebook.com/RtwWithNoah
Studly Adventurer
Joined: Mar 2002
Location: Tokyo
Oddometer: 804
RTW with Noah on a KTM 690
Let us know on Gaijinriders if you need help with info on japan.
2 scoops of stupid
Joined: Apr 2011
Location: Sacramento, CA
Oddometer: 337
Noah, fantastic ride report. I have no idea how I missed your thread until now but I can't tell you how impressed I am across the board. You are quite the gentleman of character and it shines throughout your journey. Keep up the good work and I hope you keep the party rolling for a couple more years. Oh, and you're a dick for making me ponder trading in my trusty f800 for a tasty ktm.
AdventureRiderBaja now in post production. Website AdventureRiderUSA Ride Reports: Bajalamadingdong Colorado IRELAND
Old Motorcyclist
Joined: Mar 2003
Location: Jennings, Louisiana
Oddometer: 3,477
Great report Noah and look forward to checking for updates every day.
A14 KLR 43k miles ,07 1250S Bandit 75K miles , 03 Chevy Truck 80K miles '43 model me. Simper Fi
Gnarly Adventurer
Joined: Apr 2012
Location: Calgary, Alberta
Oddometer: 211
I met Noah in a gas station last year while heading north to Alaska (he was heading south) And after a conversation over a typical gas station lunch and hearing about his trip, I got home, sold my KLR bought a 690.
Thx Noah! :)
2010 KTM 690 Enduro r (Current)
LOADED 2008 KLR (Sold)
2000 Ducati Monster 750 (Sold)
Joined: Jul 2004
Location: Concord, CA
Oddometer: 1,505
Can't believe you missed this thread. Welcome to the party. Better late than never...
Joined: May 2010
Location: In the mountains?
Oddometer: 1,695
Noah 08 KTM 690 ADV. 125,000 km. 42 countries. 5 continents and counting.
RTW Ride Report --> http://advrider.com/forums/showthread.php?t=781893
Blog ------------------> http://rtwwithnoah.blogspot.com/
Facebook------------> https://www.facebook.com/RtwWithNoah
Joined: May 2010
Location: In the mountains?
Oddometer: 1,695
Mongolia Southern route.
July 15. Olgii to camping near Khold. 255 km
15 km south of the city the construction started. The main routes in Mongolia are the worse for bumpy roads. Especially when they get beat to shit by the haul trucks. It was slowish going the whole day. If this is how the whole southern route is, I definitely did not want to take it. I came up to an overland truck parked by the road and I stopped to say hi. It was 2 older German guys who put together a rig to travel in. They were giving a ride to the 2 hitchhiking girls. At least I know they were going in style. They would run into problems and it would take them about 7 days to get to UB in that truck. The coffee was great! I knew I was on a well traveled route when I had kids asking me for food and money. On the northern route, this never happened. Also, people trying to sell you shit. There were a few people on the side of the road with an eagle you could take a picture with. I decided to stop and ask how much. "5000" he said. This is about $3 and didn't really need a picture of me with an eagle. So I start the bike to drive away.. "1000" he yells. Ok now I'll do it. We snap a few pictures and he wants me to take a pic of he and his friend. I had him 1000 and he says "5000". I tell him you said 1000. He knows I'm not going to give him 5 so he takes the 1k and pretends he wasn't trying to screw me... out of $2.30. When I was in Olgii I heard there was a quarantine around the entire area. There were rumors no one could leave or enter. I had no problem leaving but they sprayed my tires with something a few different times. Apparently they were trying to stop the spread of a livestock disease and no one could enter or leave the Altai region of Mongolia. This was further west then I was planning on going so I headed toward Khold. I found some internet in Khold and tried to find a hotel but didn't really like the options so I headed back north out of town to camp.
Custom MAN
I think she is a 2-zinger
"What is your horse's name?" "Horse's name? No."
So majestic. And the eagal is cool also.
The lady who sprayed my motorcycle tires at one of the stops.
Camp spot view.
July 16. Khold to near Altai City. 431 km
This would be know as the day of the flat tires. The Mitus E09 on my rear was separating on the inside. I must have run it at to low of pressure. It is such a hard tire, it is difficult to gauge the pressure in it by pushing on the tire. I was riding at a pretty good clip and I felt something pull on my boot. I look down and there was wire wrapped around my peg and boot. I pull over to remove it and I notice it is caught up in my sprocket, brake and chain also. At this point I spot my first flat. The wire didn't have anything to do with the flat.. just a cuincidence. I felt the inside of tire with it on the rim and couldn't find any problems. It started to rain as I was getting ready to patch the tube so I threw a new tube in it. About 30 km later the tire went flat again. Right next to a Ger with a small building where some truck drivers were eating and drinking vodka. This time I knew something was wrong with the tire so I took it off the rim. It was now obvious I had cords poking my tube. There were about 5 places that were bad so I used grip glue to glue pieces of cut inner tube to the inside of the tire. I aired it up and tired to get going but the truck drivers made me take a shot of vodka. I said just one and they agreed. I took the one and started to leave. They poured another one and wanted me to take it but I said sorry and walked out the door. It is never "just one" in these countries. 5 km down the road there was a lady with a flat tire on her little hatchback. She had 5 kids with her and and no spare. It was a newish car so I was wondering why no spare... especially driving through the desert with young kids. This is Mongolia. I rode back to the ger and tried to tel the people but they didn't seem to care. A lady and her kids will have to spend a night in the desert? No problem. This is Mongolia. I rode on about another 40 km and I felt my rear going flat again. Screw this. I'm going to bed. I rode about 1 km away from the road and pitched my tent. The flat can wait till the morning. That night a big storm came. Not much rain but lots of wind. I had to go outside and re-stake the tent with guys to hold it down. I thought my tent was going to collapse but it held. I slept surprisingly well for how hard the wind was blowing.
Many Eagles.
1st flat. And wire?
2nd flat.
These guys really wanted to give me lots of vodka.
July 17. To near Bayankhongor. 357 km
I drank coffee while I worked on my tire. I re-glued the patches inside the tire and patched the better of the 2 tubes. The other tube I cut and made a "jacket" to put around the 1st*tube to try to protect it from the tire. I had already come to the conclusion that the middle route or gobi were out of the question with my tire situation. I was down to 1 HD front tube and nothing else for the rear. After Altai city there was new paved road and construction for a while. They try to put piles of dirt to block the new road but its quite easy to get around them. You just have to make sure you don't ride into the whole where a bridge or culvert will go. So in the early afternoon I rode brand new pavement.. then freshly compacted gravel waiting for pavement.. then freshly crushed rock waiting for gravel.. then the road stopped in the middle of nowhere. I was about 10km north of the southern route on gps map so I took the 2 track in front of me. It was more enjoyable then the rest of the southern route because there wasn't any washboard or traffic. I camped as it got dark and made plans to get up early. I knew it was about 750 km to UB by major route and 800 offroad if I stayed north. Since my tire seemed to be holding I thought I would try to wake up early and do the 800 offroad. Alarm set for sunrise.
Good track and tire holding.
Weather behind me.
Weather south of me.
Weather in front of me.
Washed out roads.
July 18. To Ulaanbaatar. 744 km.
Woke up 5 minutes before the alarm and got ready to go. Quick few cups of coffee and I was on my way. I was feeling good. The caffine and adrenaline on a well rested body. I was standing up riding the 690 like it is meant to be ridden. I felt like the bike was a part of me. I had visions of Dakar bouncing in my head. All was golden for about 45 minutes when I came over a small crest and the road opened up to 20 different tracks through a slick mud hole. On any other day this would not be a problem. But it had rained for 3 days when I was on the southern route. So I had no choice but to lean back and try to make it through. Before I knew it Katriana and I were sliding in the mud at about 50 km/h. The bike did 270 degrees and I must have done more. I was sliding backwards on my back when I felt my underwear filling up with cold slimy mud. Noting was broken. Noting was hurt. Only my pride of course. I picked up the bike and tried to figure out how to get clean. Just then a Mongolian pulls up in a minivan and asked if I need help. "No! I want to sit here in my pool of mud, pity and stupidity by myself thank you!". I started the bike and rode on till the next puddle where I proceed to try and wash. Try is the key word. After Bayankhongor my rear went flat again. The fix had lasted about 500 km. The heat had made the patch fail and the tube ripped when it did. My only hope now was to put a the HD front tube in and hope it held.
Look for the silver lining when covered head to toe in mud. I came to a checkpoint/toll booth and rode up to the toll guy and cop standing there. They just looked at me. I was on the pegs and I slowed to a stop but just stood there balancing. They just looked at me. They didn't say anything. So I revved her, let out the clutch and took off. If they aren't going to demand $0.30 to ride this crap road I'm not going to give it to them.
Once I was about 200 km from UB I stopped for fuel. Something felt different. It was not the same. Then I looked around and noticed it was the same. The same as Marrakesh, the same as Bukhara, the same as Dushanbe. Busloads of tourists going just far enough away from the city to feel like they have seen the country. People taking the same picture on a camel they take in Morocco or Egypt. The same venders selling the same crap. The same game. I knew I was close to UB now. The traffic was horrible now. I was running with my bright on and still oncoming traffic would throw it out into my lane to pass. Tour buses passing tour buses to get to the same place. Somewhere in the stress of near death, a drybag with my Klim fleece, a GL tshirt and a Klim long sleeve had come loose and fallen off the moto. It was either 1 or 100 km behind me. I did not know. With all the traffic I knew it would be snatched so I did not go back. Write it as a loss. I was so close to UB I could almost see the haze. It was 96 km to go when my rear went flat again. The origami attempt to fit my front tube into the rear had finally warn through. I patched it and limped into UB at 90k per hour to try to keep the heat down. Every puddle I saw I would ride through. I needed this to hold for just a little bit longer. Finally I made it to the city and I was splitting traffic like an asshole again. Just trying to get to the Oasis, to cold beer. I pulled in and was greeted by many warm faces. Kim was there waiting on parts for his BMW. Michel and the Austrians I met in Bukhara were there. I barely had my helmet off and there was a beer handed to me. I had made it. What a relieve. The next morning the tire was flat. It had made it just as long as it needed to.
This is what dreams are made of. Feeling good this morning.
Light dew. It dried by the time I was done with my second cup of coffee.
The southern route is dry they said. There is no mud they said.
Trying to wash.
Noah 08 KTM 690 ADV. 125,000 km. 42 countries. 5 continents and counting.
RTW Ride Report --> http://advrider.com/forums/showthread.php?t=781893
Blog ------------------> http://rtwwithnoah.blogspot.com/
Facebook------------> https://www.facebook.com/RtwWithNoah
2 scoops of stupid
Joined: Apr 2011
Location: Sacramento, CA
Oddometer: 337
Fully loaded?? Piece o cake, just don't ask me to run a mile
AdventureRiderBaja now in post production. Website AdventureRiderUSA Ride Reports: Bajalamadingdong Colorado IRELAND
Beastly Adventurer
Joined: May 2012
Location: Providence, RI
Oddometer: 1,762
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Publications (24)231.77 Total impact
- SourceAvailable from: PubMed Central
Article: NOD-scidIl2rgtm1Wjl and NOD-Rag1nullIl2rgtm1Wjl: A Model for Stromal Cell–Tumor Cell Interaction for Human Colon Cancer[Show abstract] [Hide abstract]
ABSTRACT: Stromal cells and the extracellular environment are vital to human tumors, influencing growth and response to therapy. Human tumor cell lines lack stroma and transplantation into immunodeficient mice does not allow meaningful analyses of the effects of stroma on tumor cell growth. Studies of xenografts of primary human tumor fragments in nude mice and in early scid mouse models were constrained by poor tumor growth accompanied by host-versus-graft reactivity, dramatically altering tumor architecture and tumor microenvironment. In contrast, severely immunodeficient NOD-scid and NOD-Rag1 (null) strains carrying the IL2rg (null) mutation (NSG and NRG) support the growth of many types of human primary tumors. We compared the take rate, growth and architectural preservation of 10 clinically distinct primary human colon cancers in NOD-scid, NOD-Rag1 (null) , NSG and NRG mice and determined the contribution of mouse and human cells to the stroma during tumor proliferation and expansion in secondary hosts and tumor response to treatment with 5-fluorouracil (5-FU). NSG and NRG mice more readily support growth of human primary colon tumor fragments than do NOD-scid, NOD-Rag1 (null) mice and maintain tumor architectural integrity in the primary recipient and through subsequent transplant generations. The human colon tumors were responsive to treatment with 5-FU. Human stromal cells in the primary graft were replaced by mouse-derived fibroblasts in a dynamic process during subsequent passages. Human colon cancer xenografts propagated in NSG and NRG mice maintain structural fidelity while replacing human stromal cells with murine stromal cells.Digestive Diseases and Sciences 05/2014; 59(6). DOI:10.1007/s10620-014-3168-5 · 2.55 Impact Factor
Article: Mesenchymal Stem Cells Utilize CXCR4–SDF-1 Signaling for Acute, but Not Chronic, Trafficking to Gastric Mucosal Inflammation[Show abstract] [Hide abstract]
ABSTRACT: Helicobacter infection is the main risk factor in developing gastric cancer. Mesenchymal stem cells (MSCs) are non-hematopoietic stromal cells, which are able to differentiate into different cell lineages. MSC contribute to cancer development by forming the tumor directly, contributing to the microenvironment, or by promoting angiogenesis and metastasis. CXCR4/SDF-1 axis is used by MSC in trafficking, homing, and engraftment at chronic inflammation sites, and plays an important role in tumorigenesis. To determine if CXCR4 receptor has a role in MSC contribution to the development of Helicobacter-mediated gastric cancer. SDF-1 and CXCR4 expression in mouse gastric mucosa in the setting of acute and chronic inflammation was measured using RT-PCR. Mouse culture-adapted MSC express CXCR4. Wild-type C57BL/6 mice infected with Helicobacter felis for 6 months or controls were given IV injections of CXCR4 knock-down MSC. Animals were followed for another 4 months. Homing of MSC in the stomach was quantified using RT-PCR. MSC differentiation into gastric epithelia lineages was analyzed using immunohistochemistry and fluorescent in situ hybridization. CXCR4 and SDF-1 are both upregulated in the settings of Helicobacter-induced chronic gastric inflammation. CXCR4 is fully required for homing of MSC to the stomach in acute gastric inflammation, but only partially in Helicobacter-induced gastric cancer. MSC lead to gastric intraepithelial neoplasia as early as 10 months of Helicobacter infection. Our results show that MSC have a tumorigenic effect by promoting an accelerated form of gastric cancer in mice. The engraftment of MSC in chronic inflammation is only partially CXCR4-dependent.Digestive Diseases and Sciences 07/2013; 58(9). DOI:10.1007/s10620-013-2782-y · 2.55 Impact Factor
Article: Fusion of MSC With Gastric Epithelial Cells Increases Invasion and Metastasis of Gastric CancerGastroenterology 01/2011; 140(5). DOI:10.1016/S0016-5085(11)60156-X · 13.93 Impact Factor
Article: Helicobacter Infection and Gastric Cancer – Migration of MSC in Response to SDF-1/CXCR4 SignalingGastroenterology 01/2011; 140(5). DOI:10.1016/S0016-5085(11)60508-8 · 13.93 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations in tumor cells or the stromal cells may affect the switch from dormancy to malignancy. Gene mutations, including p53 mutations, within the stroma of tumors are associated with a worse clinical prognosis; however, it is not known if these stromal mutations can promote tumors in genetically at-risk tissue. To address this question, Apc(Min/+) and Apc(Min/+) Rag2(-/-) mice, which have a predilection to mammary carcinoma (as well as wild-type (wt) mice), received mesenchymal stem cells (MSC) with mutant p53 (p53MSC) transferred via tail vein injection. In the wt mouse, p53MSC circulated in the periphery and homed to the marrow cavity where they could be recovered up to a year later without apparent effect on the health of the mouse. No mammary tumors were found. However, in mice carrying the Apc(Min/+) mutation, p53MSC homed to mammary tissue and significantly increased the incidence of mammary carcinoma. Tumor necrosis factor (TNF)-alpha-dependent factors elaborated from mesenchymal cells converted quiescent epithelia into clinically apparent disease. The increased cancer phenotype was completely preventable with neutralization of TNF-alpha or by transfer of CD4(+) regulatory T cells from immune competent donors, demonstrating that immune competency to regulate inflammation was sufficient to maintain neoplastic dormancy even in the presence of oncogenic epithelial and stromal mutations. The significant synergy between host immunity and mesenchymal cells identified here may restructure treatments to restore an anticancer microenvironment.Stem cells and development 03/2010; 19(8):1153-66. DOI:10.1089/scd.2009.0439 · 4.20 Impact Factor
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ABSTRACT: The notion that tumors contain a population of cells termed cancer stem cells, or cancer initiating cells has been gaining momentum over the past several years. It is postulated that much like a normal organ in the body, tumors contain a population of stem cells which are responsible for driving tumor growth, invasion and metastasis. This becomes of paramount clinical importance because our present therapies often times shrink tumors, but do not prevent their recurrence or metastatic spread. This behavior of tumors suggests that a population of cells within the tumor capable of driving tumor growth is insensitive to our current therapies and survives to reestablish disease. Therefore, understanding the biology of the cancer stem cell which is believed responsible for this tumor re-growth, will allow targeted therapy to better treat cancers. This chapter reviews the cancer stem cell hypotheses, and investigates the potential sources for the cancer stem cell. KeywordsStem cell–Stem cell niche–Stroma–Inflammation–Cancer associated fibroblasts12/2009: pages 235-250;
Article: Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.[Show abstract] [Hide abstract]
ABSTRACT: Analysis of clinical colon cancer specimens show alterations in the CD95 (Fas Ag/Fas L) pathway as tumors progress from local to metastatic disease, suggesting that this pathway may play a role in invasive behavior of colon cancer. However, direct causality between these alterations and clinical disease progression has not been shown. Surgically resected metastatic colon cancer samples were evaluated for Fas Ag/L and apoptosis. Alterations in the Fas-signaling pathway found in human samples were recreated through a series of staged transfection experiments in the MC38 mouse colon cancer cell line and the effects on growth tested in vitro and in vivo. Expression of FLICE-like inhibitory protein confers apoptosis resistance, increasing the incidence of primary tumors through a survival advantage by avoiding apoptosis and inducing Fas-mediated proliferation. Coexpression of Fas L enables colon cancer cells to metastasize to the liver from local tumors as well as from intravenous injection of cells. MC38-FasL/FLICE-like inhibitory protein colon cancer cells induce apoptosis in hepatocytes via activation of type II Fas Ag signaling, thus creating a niche conducive to tumor growth and fueling their own growth via Fas proliferative signaling. Alterations in the Fas Ag pathway which inhibit apoptosis and increase Fas-mediated proliferation directly increase local colon cancer growth, and enhance metastasis to the liver. Delineating points in the pathway responsible for growth and metastasis will offer targets that may be exploited for therapy.Gastroenterology 07/2009; 137(3):934-44, 944.e1-4. DOI:10.1053/j.gastro.2009.06.004 · 13.93 Impact Factor
Article: 57 Bone Marrow Derived Cells Contribute to the Tumor Microenvironment and Increase the Aggressiveness of Colon Cancer CellsGastroenterology 05/2009; 136(5). DOI:10.1016/S0016-5085(09)60047-0 · 13.93 Impact Factor
Article: 85 Cultured Mouse Menchymal Stem Cells Form Hepatocytes By FUSION with Host Hepatocytes and Directly Contribute to Sinusoidal Cells By TransdifferentiationGastroenterology 05/2009; 136(5). DOI:10.1016/S0016-5085(09)63651-9 · 13.93 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: When cells within the gastric mucosa progress from metaplasia to dysplasia to cancer, they acquire a Fas Ag apoptosis-resistant phenotype. It is unusual to completely abolish the pathway, suggesting other forms of Fas Ag signaling may be important or even necessary for gastric cancer to progress. Little is known about alternate signaling of the Fas Ag pathway in gastric mucosal cells. Using a cell culture model of rat gastric mucosal cells, we show that gastric mucosal cells utilize a type II signaling pathway for apoptosis. Under conditions of low receptor stimulation or under conditions where apoptosis is blocked downstream of the death-inducing signal complex, Fas Ag signaling proceeds toward proliferative signaling. Under conditions favoring proliferative signaling, cFLIP is recruited to the Fas-associated death domain-like interleukin-1beta-converting enzyme at the death-inducing signal complex and activates ERK1/2. ERK1/2 in turn activates NF-kappaB. ERK1/2 stimulates proliferation, whereas NF-kappaB activation results in upregulation of the antiapoptotic protein survivin, further promoting proliferation over apoptosis. These results suggest that factors that inhibit apoptosis confer a growth advantage to the cells beyond the survival advantage of avoiding apoptosis and in effect convert the Fas Ag signaling pathway from a tumor suppressor to a tumor promoter.AJP Gastrointestinal and Liver Physiology 02/2008; 294(1):G263-75. DOI:10.1152/ajpgi.00267.2007 · 3.74 Impact Factor
Article: Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: A model of age-related tumorigenesis in mice[Show abstract] [Hide abstract]
ABSTRACT: Aging is the single most common risk factor for cancer. Peripheral and marrow-derived stem cells are long lived and are candidate cells for the cancer-initiating cell. Repeated rounds of replication are likely required for accumulation of the necessary genetic mutations. Based on the facts that mesenchymal stem cells (MSC) transform with higher frequency than other cell types, and tumors in aged C57BL/6 mice are frequently fibrosarcomas, we used a genetically tagged bone marrow (BM) transplant model to show that aged mice develop MSC-derived fibrosarcomas. We further show that, with aging, MSCs spontaneously transform in culture and, when placed into our mouse model, recapitulated the naturally occurring fibrosarcomas of the aged mice with gene expression changes and p53 mutation similar to the in vivo model. Spontaneously transformed MSCs contribute directly to the tumor, tumor vasculature, and tumor adipose tissue, recruit additional host BM-derived cells (BMDC) to the area, and fuse with the host BMDC. Unfused transformed MSCs act as the cancer stem cell and are able to form tumors in successive mice, whereas fusion restores a nonmalignant phenotype. These data suggest that MSCs may play a key role in age-related tumors, and fusion with host cells restores a nonmalignant phenotype, thereby providing a mechanism for regulating tumor cell activity.Cancer Research 12/2007; 67(22):10889-98. DOI:10.1158/0008-5472.CAN-07-2665 · 9.28 Impact Factor
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ABSTRACT: The tumor microenvironment, composed of non-cancer cells and their stroma, has become recognized as a major factor influencing the growth of cancer. The microenvironment has been implicated in the regulation of cell growth, determining metastatic potential and possibly determining location of metastatic disease, and impacting the outcome of therapy. While the stromal cells are not malignant per se, their role in supporting cancer growth is so vital to the survival of the tumor that they have become an attractive target for chemotherapeutic agents. In this review, we will discuss the various cellular and molecular components of the stromal environment, their effects on cancer cell dynamics, and the rationale and implications of targeting this environment for control of cancer. Additionally, we will emphasize the role of the bone marrow-derived cell in providing cells for the stroma.Journal of Cellular Biochemistry 07/2007; 101(4):805-15. DOI:10.1002/jcb.21159 · 3.37 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Cells derived from bone marrow are pluripotent, with the ability to differentiate into multiple cell types. Environmental cues dictate differentiation decisions. It should not be surprising then, that abnormal cell environments lead to abnormal differentiation of these cells, and in some cases, malignant transformation. Identifying a role for bone marrow-derived cells in the initiation and progression of cancer allows a dramatic change in the way in which cancer is viewed. Identifying the cell responsible for initiating a tumor offers the exciting possibility of specifically targeting unique aspects of these cells and altering signaling properties for more effective therapeutic approaches.Future Oncology 01/2006; 1(6):851-62. DOI:10.2217/147966126.96.36.1991 · 2.61 Impact Factor
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ABSTRACT: The initiating molecular events in Helicobacter-induced gastric carcinogenesis are not known. Early in infection, Fas antigen-mediated apoptosis depletes parietal and chief cell populations, leading to architectural distortion. As infection progresses, metaplastic and dysplastic glands appear, which are resistant to Fas-mediated apoptosis. These abnormal lineages precede, and are thought to be the precursor lesions of, gastric cancer. Acquisition of an antiapoptotic phenotype before transformation of cells suggests that loss of Fas sensitivity may be an early required trait for gastric cancer. We reasoned that forced Fas-apoptosis resistance would result in earlier and more aggressive gastric cancer in our mouse model. Fas antigen-deficient (lpr) mice or C57BL/6 wild-type mice were irradiated and reconstituted with C57BL/6 marrow forming partial lpr/wt chimera or wt/wt control mice, extending the life span of the lpr and ensuring a competent immune response to Helicobacter felis infection. Infected lpr/wt mice developed gastric cancer as early as 7 months after infection (compared with 15 months in wt/wt mice). At 10 months (90%) and 15 months (100%), mice developed aggressive invasive lesions. This earlier onset and more aggressive histology strongly argues that Fas-apoptosis resistance is an early and important feature of gastric cancer formation.Cancer Research 01/2006; 65(23):10912-20. DOI:10.1158/0008-5472.CAN-05-1802 · 9.28 Impact Factor
Article: Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation.[Show abstract] [Hide abstract]
ABSTRACT: Escape from normal apoptotic controls is thought to be essential for the development of cancer. During Helicobacter pylori infection, the leading cause of gastric cancer, activation of the Fas antigen (Fas Ag) apoptotic pathway is responsible for early atrophy and tissue loss. As disease progresses, metaplastic and dysplastic glands arise which express Fas Ag but are resistant to apoptosis and are believed to be the precursor cells for adenocarcinoma. In this report, we show that one mechanism of acquired Fas resistance is inhibition of receptor aggregation via a major histocompatibility complex class II (MHCII)-mediated, actin-dependent mechanism. For these studies we used the well-described C57BL/6 mouse model of Helicobacter pylori and Helicobacter felis infection. Under normal conditions, Fas Ag is expressed at low levels, and MHCII expression on gastric mucosal cells is negligible. With infection and inflammation, both receptors are upregulated, and 6.1% of gastric mucosal cells express MHCII in combination with Fas Ag. Using the rat gastric mucosal cell line RGM-1 transfected with murine Fas Ag and MHCIIalphabeta chains, we demonstrate that MHCII prevents Fas receptor aggregation and inhibits Fas-mediated signaling through its effects on the actin cytoskeleton. Depolymerization of actin with cytochalasin D allows receptors to aggregate and restores Fas sensitivity. These findings offer one mechanism by which gastric mucosal cells acquire Fas resistance.Infection and Immunity 11/2005; 73(10):6311-21. DOI:10.1128/IAI.73.10.6311-6321.2005 · 4.16 Impact Factor
Article: Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice[Show abstract] [Hide abstract]
ABSTRACT: The impact of Helicobacter eradication therapy on the progression or regression of gastric lesions is poorly defined. This study examined the effects of eradication therapy on inflammation, atrophy, metaplasia, dysplasia, and cancer progression. C57BL/6 mice were infected with Helicobacter felis and received bacterial eradication therapy after 2, 6, or 12 months of infection. The gastric mucosa was examined at early, mid, and late intervals after eradication and graded for histology, expression pattern of alpha-catenin and beta-catenin, and IQGAP1. Eradication of Helicobacter infection after 2 or 6 months of infection led to a regression of inflammation, restoration of parietal cell mass, and reestablishment of normal architecture. Progression to adenocarcinoma was prevented. Bacterial eradication at 1 year was associated with the reappearance of parietal cells, partial regression of inflammation, and restoration of architecture. Hyperplasia scores significantly improved, and dysplasia did not progress. Infected mice developed antral adenocarcinoma and gastric outlet obstruction by 24 months. Only 30% of the mice receiving bacterial eradication therapy at 12 months developed antral carcinoma. Bacterial eradication at any time during the first year of infection prevented death due to gastric outlet obstruction. The expression pattern of alpha-catenin, beta-catenin, and IQGAP1 varied with cell type and paralleled histologic changes. Inflammation, metaplasia, and dysplasia are reversible with early eradication therapy; progression of dysplasia was arrested with eradication therapy given as late as 1 year and prevented gastric cancer-related deaths.Gastroenterology 07/2005; 128(7):1937-52. DOI:10.1053/j.gastro.2005.02.066 · 13.93 Impact Factor
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ABSTRACT: Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.Science 12/2004; 306(5701):1568-71. DOI:10.1126/science.1099513 · 31.48 Impact Factor
Article: Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections.[Show abstract] [Hide abstract]
ABSTRACT: The host immune response plays a critical role in determining disease manifestations of chronic infections. Inadequate immune response may fail to control infection, although in other cases the specific immune response may be the cause of tissue damage and disease. The majority of patients with chronic infections are infected by more than one organism yet the interaction between multiple active infections is not known, nor is the impact on disease outcome clear. Using the BALB/c strain of mice, we show that Toxoplasma gondii infection in a host infected with Helicobacter felis alters the natural outcome of T. gondii infection, allowing uncontrolled tachyzoite replication and severe organ damage. Survival rates decrease from 95% in T. gondii infection alone to 50% in dual-infected mice. In addition, infection with T. gondii alters the specific H. felis immune response, converting a previously resistant host to a susceptible phenotype. Gastric mucosal IFN-gamma and IL-12 were significantly elevated and IL-10 substantially reduced in dual-infected mice. These changes were associated with severe gastric mucosal inflammation, parietal cell loss, atrophy, and metaplastic cell changes. These data demonstrate the profound interactions between the immune response to unrelated organisms, and suggest these types of interactions my impact clinical disease.The Journal of Immunology 10/2004; 173(5):3329-36. DOI:10.4049/jimmunol.173.5.3329 · 5.36 Impact Factor
Article: Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility.[Show abstract] [Hide abstract]
ABSTRACT: Helicobacter infection is the single most common cause of gastric cancer worldwide. Although infection prevention and eradication of established infection offer the potential for cure, these strategies are neither feasible nor practical for widespread implementation. Patients most at risk need to be identified and targeted for treatment. For disease to occur, bacterial, environmental, and nutritional factors require a genetically susceptible host. Consequently, it is important to understand how the organism interacts with the host to cause disease. Only through an understanding of what places a patient at risk can we hope to identify susceptible patients early enough in disease to have an impact on their outcome. The immune response is the single most important determinant of disease. Single nucleotide polymorphisms within the promoter region of several critical proinflammatory genes dramatically increase the risk of Helicobacter-associated gastric cancer. Additionally, environmental and dietary factors may modulate the immune response or directly influence key apoptotic and proliferative signaling cascades to alter disease presentation. Lastly, concurrent disease states may have a dramatic impact on the host response to Helicobacter infection and influence disease. An understanding of the immune signaling pathways responsible for disease and the ways in which environmental risk factors influence these pathways will allow identification of populations that are most at risk and targeted prevention and treatment strategies.Current Gastroenterology Reports 01/2004; 5(6):459-67. DOI:10.1007/s11894-003-0034-6
Article: Gastric mucosal cells can act a non professional antigen presenting cells in the milieu of Helicobacter infection; the role of IFN-λ and Fas signalingGastroenterology 04/2003; 124(4). DOI:10.1016/S0016-5085(03)82045-0 · 13.93 Impact Factor
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University of Massachusetts Medical School
Worcester, Massachusetts, United States
- • Department of Medicine
- • Department of Cancer Biology
University of Massachusetts AmherstAmherst Center, Massachusetts, United States
Massachusetts Institute of TechnologyCambridge, Massachusetts, United States