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Publications (23)129.76 Total impact
Article: Identification of Small Molecule Modulators of Gene Transcription with Anti-Cancer Activity.[Show abstract] [Hide abstract]
ABSTRACT: Epigenetic regulation of gene expression is essential in many biological processes and its deregulation contributes to pathology including tumor formation. We used an image-based cell assay that measures the induction of a silenced GFP-estrogen receptor reporter to identify novel classes of small molecules involved in the regulation of gene expression. Using this Locus Derepression assay, we queried 283,122 compounds by quantitative high-throughput screening evaluating compounds at multiple concentrations. After confirmation and independent validation, the Locus Derepression assay identified 19 small molecules as new actives that induce the GFP message over two fold. Viability assays demonstrated 17 of these actives have anti-proliferative activity and two of them show selectivity for cancer vs. patient matched normal cells and cause unique changes in gene expression patterns in cancer cells. Hence, these compounds represent chemical tools for understanding the molecular mechanisms of epigenetic control of transcription and for modulating cell growth pathways.ACS Chemical Biology 09/2014; DOI:10.1021/cb500532x · 5.36 Impact Factor
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ABSTRACT: Retinoic acid-related orphan receptor RORγt plays a pivotal role in the differentiation of TH17 cells. Antagonizing RORγt transcriptional activity is a potential means to treat TH17-related autoimmune diseases. Herein, we describe the identification of a series of diphenylpropanamides as novel and selective RORγ antagonists. Diphenylpropanamide 4n inhibited transcriptional activity of RORγt, but not RORα, in cells. In addition, it suppressed human TH17 cell differentiation at sub-micromolar concentrations.ACS Medicinal Chemistry Letters 01/2013; 4(1):79-84. DOI:10.1021/ml300286h · 3.07 Impact Factor
Article: A Class of Tricyclic Compounds Blocking Malaria Parasite Oocyst Development and Transmission[Show abstract] [Hide abstract]
ABSTRACT: Malaria is a deadly infectious disease in many tropical and subtropical countries. Previous efforts to eradicate malaria have failed, largely due to the emergence of drug-resistant parasites, insecticide-resistant mosquitoes and, in particular, the lack of drugs or vaccines to block parasite transmission. ATP-binding cassette (ABC) transporters are known to play a role in drug transport, metabolism, and resistance in many organisms, including malaria parasites. To investigate whether a Plasmodium falciparum ABC transporter (Pf14_0244 or PfABCG2) modulates parasite susceptibility to chemical compounds or plays a role in drug resistance, we disrupted the gene encoding PfABCG2, screened the recombinant and the wild-type 3D7 parasites against a library containing 2,816 drugs approved for human or animal use, and identified an antihistamine (ketotifen) that became less active against the PfABCG2-disrupted parasite in culture. In addition to some activity against asexual stages and gametocytes, ketotifen was highly potent in blocking oocyst development of P. falciparum and the rodent parasite Plasmodium yoelii in mosquitoes. Tests of structurally related tricyclic compounds identified additional compounds having similar activities in inhibiting transmission. Additionally, ketotifen appeared to have some activity against relapse of Plasmodium cynomolgi in rhesus monkeys. Further clinical evaluation of ketotifen and related compounds, including synthetic new derivatives, in blocking malaria transmission may provide new weapons for the current effort of malaria eradication.Antimicrobial Agents and Chemotherapy 11/2012; 57(1). DOI:10.1128/AAC.00920-12 · 4.45 Impact Factor
Article: High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them[Show abstract] [Hide abstract]
ABSTRACT: High-throughput screening (HTS) provides a rapid and comprehensive approach to identifying compounds that target specific biological processes as well as genes that are essential to those processes. Here we describe a HTS assay for small molecules that induce either DNA re-replication or endoreduplication (i.e. excess DNA replication) selectively in cells derived from human cancers. Such molecules will be useful not only to investigate cell division and differentiation, but they may provide a novel approach to cancer chemotherapy. Since induction of DNA re-replication results in apoptosis, compounds that selectively induce DNA re-replication in cancer cells without doing so in normal cells could kill cancers in vivo without preventing normal cell proliferation. Furthermore, the same HTS assay can be adapted to screen siRNA molecules to identify genes whose products restrict genome duplication to once per cell division. Some of these genes might regulate the formation of terminally differentiated polyploid cells during normal human development, whereas others will prevent DNA re-replication during each cell division. Based on previous studies, we anticipate that one or more of the latter genes will prove to be essential for proliferation of cancer cells but not for normal cells, since many cancer cells are deficient in mechanisms that maintain genome stability.Methods 04/2012; 57(2):234-48. DOI:10.1016/j.ymeth.2012.03.031 · 3.22 Impact Factor
Article: Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.[Show abstract] [Hide abstract]
ABSTRACT: Malaria remains a devastating disease largely because of widespread drug resistance. New drugs and a better understanding of the mechanisms of drug action and resistance are essential for fulfilling the promise of eradicating malaria. Using high-throughput chemical screening and genome-wide association analysis, we identified 32 highly active compounds and genetic loci associated with differential chemical phenotypes (DCPs), defined as greater than or equal to fivefold differences in half-maximum inhibitor concentration (IC(50)) between parasite lines. Chromosomal loci associated with 49 DCPs were confirmed by linkage analysis and tests of genetically modified parasites, including three genes that were linked to 96% of the DCPs. Drugs whose responses mapped to wild-type or mutant pfcrt alleles were tested in combination in vitro and in vivo, which yielded promising new leads for antimalarial treatments.Science 08/2011; 333(6043):724-9. DOI:10.1126/science.1205216 · 31.48 Impact Factor
Article: Discovery of new antimalarial chemotypes through chemical methodology and library development[Show abstract] [Hide abstract]
ABSTRACT: In an effort to expand the stereochemical and structural complexity of chemical libraries used in drug discovery, the Center for Chemical Methodology and Library Development at Boston University has established an infrastructure to translate methodologies accessing diverse chemotypes into arrayed libraries for biological evaluation. In a collaborative effort, the NIH Chemical Genomics Center determined IC(50)'s for Plasmodium falciparum viability for each of 2,070 members of the CMLD-BU compound collection using quantitative high-throughput screening across five parasite lines of distinct geographic origin. Three compound classes displaying either differential or comprehensive antimalarial activity across the lines were identified, and the nascent structure activity relationships (SAR) from this experiment used to initiate optimization of these chemotypes for further development.Proceedings of the National Academy of Sciences 04/2011; 108(17):6775-80. DOI:10.1073/pnas.1017666108 · 9.81 Impact Factor
Article: A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2.[Show abstract] [Hide abstract]
ABSTRACT: The thyroid hormone receptors (TR) are members of the nuclear hormone receptor (NHR) superfamily that regulate development, growth, and metabolism. Upon ligand binding, TR releases bound corepressors and recruits coactivators to modulate target gene expression. Steroid receptor coactivator 2 (SRC2) is an important coregulator that interacts with TRβ to activate gene transcription. To identify novel inhibitors of the TRβ and SRC2 interaction, the authors performed a quantitative high-throughput screen (qHTS) of a TRβ-SRC2 fluorescence polarization assay against more than 290 000 small molecules. The qHTS assayed compounds at 6 concentrations up to 92 µM to generate titration-response curves and determine the potency and efficacy of all compounds. The qHTS data set enabled the characterization of actives for structure-activity relationships as well as for potential artifacts such as fluorescence interference. Selected qHTS actives were tested in the screening assay using fluoroprobes labeled with Texas Red or fluorescein. The retest identified 19 series and 4 singletons as active in both assays with 40% or greater efficacy, free of compound interference, and not toxic to mammalian cells. Selected compounds were tested as independent samples, and a methylsulfonylnitrobenzoate series inhibited the TRβ-SRC2 interaction with 5 µM IC(50). This series represents a new class of thyroid hormone receptor-coactivator modulators.Journal of Biomolecular Screening 04/2011; 16(6):618-27. DOI:10.1177/1087057111402199 · 2.01 Impact Factor
Article: An Image-Based, High-Throughput Screening Assay for Molecules that Induce Excess DNA Replication in Human Cancer Cells[Show abstract] [Hide abstract]
ABSTRACT: Previous studies have shown DNA re-replication can be induced in cells derived from human cancers under conditions in which it is not possible for cells derived from normal tissues. Because DNA re-replication induces cell death, this strategy could be applied to the discovery of potential anticancer therapeutics. Therefore, an imaging assay amenable to high-throughput screening was developed that measures DNA replication in excess of four genomic equivalents in the nuclei of intact cells and indexes cell proliferation. This assay was validated by screening a library of 1,280 bioactive molecules on both normal and tumor-derived cells where it proved more sensitive than current methods for detecting excess DNA replication. This screen identified known inducers of excess DNA replication, such as inhibitors of microtubule dynamics, and novel compounds that induced excess DNA replication in both normal and cancer cells. In addition, two compounds were identified that induced excess DNA replication selectively in cancer cells and one that induced endocycles selectively in cancer cells. Thus, this assay provides a new approach to the discovery of compounds useful for investigating the regulation of genome duplication and for the treatment of cancer.Molecular Cancer Research 03/2011; 9(3):294-310. DOI:10.1158/1541-7786.MCR-10-0570 · 4.50 Impact Factor
Article: Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.[Show abstract] [Hide abstract]
ABSTRACT: Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor (NR) superfamily and regulate development, growth, and metabolism. Upon binding thyroid hormone, TR undergoes a conformational change that allows the release of corepressors and the recruitment of coactivators, which in turn regulate target gene transcription. Although a number of TR antagonists have been developed, most are analogs of the endogenous hormone that inhibit ligand binding. In a screen for inhibitors that block the association of TRβ with steroid receptor coactivator 2 (SRC2), we identified a novel methylsulfonylnitrobenzoate (MSNB)-containing series that blocks this interaction at micromolar concentrations. Here we have studied a series of MSNB analogs and characterized their structure activity relationships. MSNB members do not displace thyroid hormone T3 but instead act by direct displacement of SRC2. MSNB series members are selective for the TR over the androgen, vitamin D, and PPARγ NR members, and they antagonize thyroid hormone-activated transcription action in cells. The methylsulfonylnitro group is essential for TRβ antagonism. Side-chain alkylamine substituents showed better inhibitory activity than arylamine substituents. Mass spectrum analysis suggested that MSNB inhibitors bind irreversibly to Cys-298 within the AF-2 cleft of TRβ to disrupt SRC2 association.Journal of Biological Chemistry 02/2011; 286(14):11895-908. DOI:10.1074/jbc.M110.200436 · 4.60 Impact Factor
Chapter: High Throughput Screening for Small Molecule Inhibitors of Heparin-induced Tau Fibril Formation[Show abstract] [Hide abstract]
ABSTRACT: The microtubule-associated protein tau contributes directly or indirectly to key structural and regulatory cellular functions. Under pathological conditions, tau becomes sequestered into insoluble neurofibrillary tangles that promote axonal transport deficits, ultimately lead to synaptic dysfunction and neuronal loss. Beta-amyloid protein undergoes a similar type of aggregation as tau, and is implicated in the pathology of Alzheimer's disease. Recent reports describing screening of libraries of small molecules for their ability to inhibit tau fibrillization have shown that some classes of compounds, such as anthraquinones, phenothiazines, and porphyrins have the ability to inhibit tau fibril formation. While these hits may be unlikely to be developed into novel therapeutics for the treatment of tauopathies, the results suggest that in vitro assays used for these screenings are capable of detecting inhibitors of tau fibrillization. Thus, further qHTS for small molecule inhibitors of heparin-induced tau fibril formation promises to provide the identification novel and more tractable hits. HTS screening identified the probe ML103 (CID-9795907) as a member of a series of tau oligomerization/fibrillization inhibitors that can be used to study tau protein aggregation in vitro, as well as a starting point for drug development for the treatment of Alzheimer's Disease (AD) and other tauopathies.Probe Reports from the NIH Molecular Libraries Program, 01/2010; National Center for Biotechnology Information (US).
Chapter: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2[Show abstract] [Hide abstract]
ABSTRACT: Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor superfamily and regulate many homeostatic processes, including basal metabolism, cardiovascular function, body weight, and lipid trafficking. Upon binding of the ligand triiodothyronine (T3), TR undergoes a conformational change that releases corepressors and recruits coactivators, such as Steroid Receptor Coactivator 2 (SRC2); in turn, these modulate the expression of target genes. In this report, we used a TRβ-SRC2 fluorescence polarization assay to screen the Molecular Libraries Small Molecule Repository (MLSMR) and identify a novel methylsulfonylnitrobenzoate (MSNB)-containing series that blocks the association of TRβ with a SRC2 peptide. This inhibitor probe molecule, ML151 (CID 5184800), blocked TRβ-SRC2 interaction with a potency of 1.8μM. Mechanistic studies revealed that ML151 (CID 5184800) is a covalent inhibitor and binds irreversibly to Cys298 within the AF-2 cleft of TRβ. This series will be useful for in vitro mechanistic studies of TR-SRC2 interactions, as well as other nuclear hormone receptor-coactivator interactions.Probe Reports from the NIH Molecular Libraries Program, 01/2010; National Center for Biotechnology Information (US).
Article: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum[Show abstract] [Hide abstract]
ABSTRACT: Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were active in inhibiting parasite growth; 607 differential chemical phenotypes, defined as pairwise IC(50) differences of fivefold or more between parasite lines, were cataloged. We mapped major determinants for three differential chemical phenotypes between the parents of a genetic cross, and we identified target genes by fine mapping and testing the responses of parasites in which candidate genes were genetically replaced with mutant alleles. Differential sensitivity to dihydroergotamine methanesulfonate (1), a serotonin receptor antagonist, was mapped to a gene encoding the homolog of human P-glycoprotein (PfPgh-1). This study identifies new leads for antimalarial drugs and demonstrates the utility of a high-throughput chemical genomic strategy for studying malaria traits.Nature Chemical Biology 10/2009; 5(10):765-71. DOI:10.1038/nchembio.215 · 13.22 Impact Factor
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ABSTRACT: The NIH Chemical Genomics Center (NCGC) was the inaugural center of the Molecular Libraries and Screening Center Network (MLSCN). Along with the nine other research centers of the MLSCN, the NCGC was established with a primary goal of bringing industrial technology and experience to empower the scientific community with small molecule compounds for use in their research. We intend this review to serve as 1) an introduction to the NCGC standard operating procedures, 2) an overview of several of the lessons learned during the pilot phase and 3) a review of several of the innovative discoveries reported during the pilot phase of the MLSCN.Current topics in medicinal chemistry 10/2009; 9(13):1181-93. DOI:10.2174/156802609789753644 · 3.45 Impact Factor
Article: A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries.[Show abstract] [Hide abstract]
ABSTRACT: Small molecule modulators are critical for dissecting and understanding signaling pathways at the molecular level. Interleukin 6 (IL-6) is a cytokine that signals via the JAK-STAT pathway and is implicated in cancer and inflammation. To identify modulators of this pathway, we screened a chemical collection against an IL-6 responsive cell line stably expressing a beta-lactamase reporter gene fused to a sis-inducible element (SIE-bla cells). This assay was optimized for a 1536-well microplate format and screened against 11 693 small molecules using quantitative high-throughput screening (qHTS), a method that assays a chemical library at multiple concentrations to generate titration-response profiles for each compound. The qHTS recovered 564 actives with well-fit curves that clustered into 32 distinct chemical series of 13 activators and 19 inhibitors. A retrospective analysis of the qHTS data indicated that single concentration data at 1.5 and 7.7 microM scored 35 and 71% of qHTS actives, respectively, as inactive and were therefore false negatives. Following counter screens to identify fluorescent and non-selective series, we found four activator and one inhibitor series that modulated SIE-bla cells but did not show similar activity in reporter gene assays induced by EGF and hypoxia. Small molecules within these series will make useful tool compounds to investigate IL-6 signaling mediated by JAK-STAT activation.Molecular BioSystems 10/2009; 5(9):1039-50. DOI:10.1039/b902021g · 3.18 Impact Factor
Article: Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening[Show abstract] [Hide abstract]
ABSTRACT: Inclusions comprised of fibrils of the microtubule- (MT-) associated protein tau are found in the brains of those with Alzheimer's disease (AD) and other neurodegenerative tauopathies. The pathology that is observed in these diseases is believed to result from the formation of toxic tau oligomers or fibrils and/or from the loss of normal tau function due to its sequestration into insoluble deposits. Hence, small molecules that prevent tau oligomerization and/or fibrillization might have therapeutic value. Indeed, examples of such compounds have been published, but nearly all have properties that render them unsuitable as drug candidates. For these reasons, we conducted quantitative high-throughput screening (qHTS) of approximately 292000 compounds to identify drug-like inhibitors of tau assembly. The fibrillization of a truncated tau fragment that contains four MT-binding domains was monitored in an assay that employed complementary thioflavin T fluorescence and fluorescence polarization methods. Previously described classes of inhibitors as well as new scaffolds were identified, including novel aminothienopyridazines (ATPZs). A number of ATPZ analogues were synthesized, and structure-activity relationships were defined. Further characterization of representative ATPZ compounds showed they do not interfere with tau-mediated MT assembly, and they are significantly more effective at preventing the fibrillization of tau than the Abeta(1-42) peptide which forms AD senile plaques. Thus, the ATPZ molecules described here represent a novel class of tau assembly inhibitors that merit further development for testing in animal models of AD-like tau pathology.Biochemistry 08/2009; 48(32):7732-45. DOI:10.1021/bi9006435 · 3.19 Impact Factor
Article: A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression[Show abstract] [Hide abstract]
ABSTRACT: Epigenetic regulation of gene expression is essential in embryonic development and contributes to cancer pathology. We used a cell-based imaging assay that measures derepression of a silenced green fluorescent protein (GFP) reporter to identify novel classes of compounds involved in epigenetic regulation. This locus derepression (LDR) assay was screened against a 69,137-member chemical library using quantitative high-throughput screening (qHTS), a titration-response method that assays compounds at multiple concentrations. From structure-activity relationships of the 411 actives recovered from the qHTS, 6 distinct chemical series were chosen for further study. A total of 48 qHTS actives and analogs were counterscreened using the parental line of the LDR cells, which lack the GFP reporter. Three series-8-hydroxy quinoline, quinoline-8-thiol, and 1,3,5-thiadiazinane-2-thione-were not fluorescent and reconfirmed activity in the LDR cells. The three active series did not inhibit histone deacetylase activity in nuclear extracts or reactivate the expression of the densely methylated p16 gene in cancer cells. However, one series induced expression of the methylated CDH13 gene and inhibited the viability of several lung cancer lines at submicromolar concentrations. These results suggest that the identified small molecules act on epigenetic or transcriptional components and validate our approach of using a cell-based imaging assay in conjunction with qHTS.Analytical Biochemistry 05/2008; 375(2):237-48. DOI:10.1016/j.ab.2007.12.028 · 2.31 Impact Factor
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ABSTRACT: To aid in the interpretation of high-throughput screening (HTS) results derived from luciferase-based assays, we used quantitative HTS, an approach that defines the concentration-response behavior of each library sample, to profile the ATP-dependent luciferase from Photinus pyralis against more than 70,000 samples. We found that approximately 3% of the library was active, containing only compounds with inhibitory concentration-responses, of which 681 (0.9%) exhibited IC 50 < 10 microM. Representative compounds were shown to inhibit purified P. pyralis as well as several commercial luciferase-based detection reagents but were found to be largely inactive against Renilla reniformis luciferase. Light attenuation by the samples was also examined and found to be more prominent in the blue-shifted bioluminescence produced by R. reniformis luciferase than in the bioluminescence produced by P. pyralis luciferase. We describe the structure-activity relationship of the luciferase inhibitors and discuss the use of this data in the interpretation of HTS results and configuration of luciferase-based assays.Journal of Medicinal Chemistry 04/2008; 51(8):2372-86. DOI:10.1021/jm701302v · 5.48 Impact Factor
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ABSTRACT: Alzheimer disease is diagnosed postmortem by the density and spatial distribution of beta-amyloid plaques and tau-bearing neurofibrillary tangles. The major protein component of each lesion adopts cross-beta-sheet conformation capable of binding small molecules with submicromolar affinity. In many cases, however, Alzheimer pathology overlaps with Lewy body disease, characterized by the accumulation of a third cross-beta-sheet forming protein, alpha-synuclein. To determine the feasibility of distinguishing tau aggregates from beta-amyloid and alpha-synuclein aggregates with small molecule probes, a library containing 72,455 small molecules was screened for antagonists of tau-aggregate-mediated changes in Thioflavin S fluorescence, followed by secondary screens to distinguish the relative affinity for each substrate protein. Results showed that >10-fold binding selectivity among substrates could be achieved, with molecules selective for tau aggregates containing at least three aromatic or rigid moieties connected by two rotatable bonds.Neurobiology of Disease 01/2008; 28(3):251-60. DOI:10.1016/j.nbd.2007.07.018 · 5.20 Impact Factor
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ABSTRACT: High-throughput screening (HTS) assays enable the testing of large numbers of chemical substances for activity in diverse areas of biology. The biological responses measured in HTS assays span isolated biochemical systems containing purified receptors or enzymes to signal transduction pathways and complex networks functioning in cellular environments. This Review addresses factors that need to be considered when implementing assays for HTS and is aimed particularly at investigators new to this field. We discuss assay design strategies, the major detection technologies and examples of HTS assays for common target classes, cellular pathways and simple cellular phenotypes. We conclude with special considerations for configuring sensitive, robust, informative and economically feasible HTS assays.Nature Chemical Biology 09/2007; 3(8):466-79. DOI:10.1038/nchembio.2007.17 · 13.22 Impact Factor
Article: Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.[Show abstract] [Hide abstract]
ABSTRACT: High-throughput screening (HTS) of chemical compounds to identify modulators of molecular targets is a mainstay of pharmaceutical development. Increasingly, HTS is being used to identify chemical probes of gene, pathway, and cell functions, with the ultimate goal of comprehensively delineating relationships between chemical structures and biological activities. Achieving this goal will require methodologies that efficiently generate pharmacological data from the primary screen and reliably profile the range of biological activities associated with large chemical libraries. Traditional HTS, which tests compounds at a single concentration, is not suited to this task, because HTS is burdened by frequent false positives and false negatives and requires extensive follow-up testing. We have developed a paradigm, quantitative HTS (qHTS), tested with the enzyme pyruvate kinase, to generate concentration-response curves for >60,000 compounds in a single experiment. We show that this method is precise, refractory to variations in sample preparation, and identifies compounds with a wide range of activities. Concentration-response curves were classified to rapidly identify pyruvate kinase activators and inhibitors with a variety of potencies and efficacies and elucidate structure-activity relationships directly from the primary screen. Comparison of qHTS with traditional single-concentration HTS revealed a high prevalence of false negatives in the single-point screen. This study demonstrates the feasibility of qHTS for accurately profiling every compound in large chemical libraries (>10(5) compounds). qHTS produces rich data sets that can be immediately mined for reliable biological activities, thereby providing a platform for chemical genomics and accelerating the identification of leads for drug discovery.Proceedings of the National Academy of Sciences 09/2006; 103(31):11473-8. DOI:10.1073/pnas.0604348103 · 9.81 Impact Factor
Top Journals
National Human Genome Research InstituteMaryland, United States
National Institutes of Health
Maryland, United States
- NIH Chemical Genomics Center (NCGC)


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Thomas Beall Griffith
Alex Kozinski, Conferences / Symposia, Constitutional Law, Federal Judges, Federalist Society, Videos, YouTube
Should Natural Law Inform Constitutional Law?
That was the subject of a recent debate between Professor Hadley Arkes and Chief Judge Alex Kozinski. Check it out….
Alex Kozinski, Clerkships, Fabulosity, Federal Judges, Feeder Judges, J. Harvie Wilkinson III, John Bash, Law Schools, SCOTUS, Solicitor General's Office, Supreme Court, Supreme Court Clerks
Supreme Court Clerk Hiring Watch: Color Commentary on the October Term 2012 Class
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Kinney's Evan Jowers Now Permanently Based In Hong Kong
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Clerkships, Fabulosity, Federal Judges, Feeder Judges, SCOTUS, Supreme Court, Supreme Court Clerks
Supreme Court Clerk Hiring Watch: OT 2012 and OT 2013
Supreme Court opinions can be loooong! But at least the justices have their trusty Supreme Court clerks, three dozen or so of the nation's brightest young legal minds, to help get everything done. Thanks to everyone who responded to our recent request for tips about law clerk hiring activity at SCOTUS. Let's take a look at what we've learned, shall we?


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The Message audio Bible is now available on Bible Gateway! Click to learn more.
32:15 Jeshurun. From the Hebrew term for "upright" (yashar). Often used to represent Israel as the upright people of a holy and righteous God (33:5, 26; Is. 44:2), here the term is used ironically.
grew fat, and kicked. Israel is described with the telling figure of a well-fed ox.


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Illumitex is an industry-leading manufacturer of precision LEDs and LED lighting fixtures
Illumitex has radically transformed traditional LED design with the creation of LED lighting that emits a uniform, highly precise beam directly from the source. With die-level optical integration, cumbersome and inefficient secondary optics to control light are unnecessary, opening the world to more versatile—and energy efficient—lighting applications than ever before imagined.
Founded in 2005 in Austin, Texas, by semiconductor and optics industry veterans, Illumitex's industry-shifting achievements began with a fresh approach to traditional LED design. By refusing to settle for the losses associated with secondary optics, Illumitex engineers utilized fundamental physics principles to maximize light extraction from the source. By extracting and directing photons at the die level, Illumitex delivers more usable light to the intended target while consuming less energy. All of this is achieved in the smallest form factor available on the market. With this innovative design shift, Illumitex promises to lead the LED lighting industry into a new realm of possibilities.
White-light applications of Illumitex's products include warehouses, offices, commercial landscapes, cold storage, food processing, grocery display and building exteriors. Horticultural lighting applications include grow lights for large growers, indoor gardens, vertical farms, greenhouses, grow containers and green walls.
For the general lighting industry, Illumitex technology enables the development of smaller and more efficient lighting solutions that improve quality of light—and life—wherever LEDs are used. For architectural lighting designers, Illumitex LEDs inspire creativity with the ability to "paint with light" by delivering perfectly uniform color blending precisely to the intended target. For the horticulture industry, Illumitex LED lights deliver custom-spectra photons directly and uniformly on plants, allowing growers to produce plants in less time and with less energy.
News From Illumitex
11 Jun
Two Horticultural Lighting Industry Veterans Join Illumitex TeamIllumitex Inc., LED innovator and maker of the world's most optically advanced lighting products, today announced the addition of Paul Hardej and Mathieu van de Sande to its team of horticulture lighting experts.
15 May
Illumitex on Austin's A-List of Most Promising Startups in 2015Illumitex is selected as one of Austin's most promising startup companies by the city's chamber of commerce
02 Apr
Indoor Harvest, Corp. to Introduce Low Cost Vertical Farming Platform at Indoor Ag-ConHOUSTON, MARCH 23, 2015 — Indoor Harvest, Corp. (OTC Pink: INQD), through its brand name Indoor Harvest, is a design build contractor, developer, marketer and direct-seller of commercial grade aeroponic and hydro...


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Jason Varitek was on the 'list.' It was why so many made it a point to tune into WAAF Wednesday morning to hear the catcher give his side of the story. But why?
By all accounts, Varitek was diligent as ever, going about his business in the same manner he always had. And even though his performance certainly didn't help matters in the Red Sox' historically bad final month -- going 2-for-26 (.077), while only throwing out one of the 20 basestealers he faced in September -- it shouldn't have lumped him in with those who were being identified as bringing the clubhouse down.
No, the reason for the demand that Varitek address the masses was simply because of one letter: 'C.'
The 39-year-old was the captain of the fastest sinking ship in baseball history, thereby surfacing his name among the others. Edward Smith, the captain of the Titantic, wasn't the one who was supposed to spot the iceberg, yet he is front and center of the boat's Wikipedia page. When the historical documents are drawn up regarding the 2011 Red Sox, expect Varitek's name to get similar billing.
Why? Because he's named captain of a baseball team seven years before? This wave of drama has brought a lot of things to light about the way of the world in Major League Baseball, including exactly how silly it is to have a a big league ballplayer wear that single letter on his chest.
No crying in baseball? How about no captains?
At least we knew what Smith was supposed to do. Occasionally help steer the ship. Make sure the crew is properly delegated. Keep in communication with other boats. And occasionally have dinner with Kate Winslet. But, to this day, nobody can identify what Varitek was -- and is -- supposed to do as a result of his title.
Talking to WEEI.com in the middle of September, Varitek said, "They didn't put a 'C' on my jersey to make me all of a sudden someone I'm not."
He later added, "It didn't change anything I did. If anything, as a person and as a human being, as I've evolved in my position, I've learned to maybe talk more, maybe communicate more. I don't know if that's because of [being a captain] or just because of change. I still need to do all the little things and understand I have to lead vocally, sometimes not, and sometimes just listen.
"It was kind of what I had already done. As I've matured more and grown more I've learned to communicate more. I've played less and I can see more. It adapts every year according to what's going on. I continue to try and read what the heartbeat is and what is going on. Today, tomorrow, you just continue to do that."
Unlike some in the Sox clubhouse, Varitek stayed true to his approach during the downturn (as did, by most accounts, Sox manager Terry Francona). The problem, in the captain's case, was that talking individually to teammates, and leading by example wasn't what many outside the Red Sox clubhouse wanted from the captain. The demand was more for the person who was going to bring the stool into the middle of the room and distribute a heavy dose of inspiration to semi-fearful gathering.
That's not how baseball works. That wasn't how Varitek worked.
There is more of a sentiment than ever that the backstop has played his last game in a Red Sox uniform, leading some to surmise who might be the next captain. There have been 19 of them in team history, with the organization actually surviving from 1990-2004 without any player carrying the title. Will it be Dustin Pedroia? Somebody else?
This disaster likely will teach the Red Sox more than a few lessons, among them being what a mistake it is to carry a captain.
This isn't football, where practices are much more prevalent than games, and the captaincies are determined on a year-to-year, and even week-to-week, basis that respond to specific circumstances on a team in any given year. Once you give out the 'C' in baseball, there is no turning back. It doesn't matter if the player's role is altered, his responsibilities are tweaked, or if the clubhouse dynamic does an about-face. Like it or not, you have your captain.
In his book, "Watching Baseball: Discovering the Game Within the Game," Jerry Remy -- who was named captain of the California Angels at the age of 24 in '77, puts it succinctly when writing, "There's probably no need for a captain on a major league team. I think there are guys who lead by example. You could name the best player on your team as captain, but he may not be the guy other players will talk to or who will quietly go to other players and give them a prod."
In the world of baseball, it is just a bad idea. Sure, it was great symbolism for the Red Sox throughout Varitek's run, with players seemingly taking comfort in calling the business-like catcher "El Capitan" while genuinely relishing in the idea that their team had somebody carrying such a title.
But there is a reason there will be just two captains in Major League Baseball -- Derek Jeter (Yankees) and Paul Konerko (White Sox) -- after Varitek leaves the Sox. It's simply not worth it.
Konerko has been captain of the White Sox for six seasons. And while he jokes about the reverence of the title, citing the inability to execute such tasks as argue penalties like his hockey-playing brethren, the first baseman seems to possess an authentic ownership of the role. But there is also a reason why if Konerko left via free agency prior to the '11 season the White Sox were going to go without a captain -- it simply is not a necessity.
And even Jeter has felt the hollowness of the title as the years have gone on. In a poll conducted by the Wall Street Journal in the middle of the '11 season, Yankees players were asked which Yankee player would be most likely to be voted class president. The shortstop didn't get a single vote.
Times change. Personnel changes. Personalities change.
A baseball clubhouse is an eclectic mix, the kind that needs a division of leadership. It is often difficult for pitchers to be led by position players, and vice versa.
As Pedroia put it when appearing on The Big Show earlier in October: "Everyone's different. We have a lot of leaders on our team. That's the thing, when I read, that kind of gets to me. Tek's the type that leads by example but when you get out of line he's going to say a couple of things to you and there's no questions asked and there's no barking back, you do it. That's how Tek runs his ship and it's very effective. He's pretty scary. You guys all see him.
"I get to the field at 1 and I go to work. That's what I do. I'm hitting all the time. I'm taking groundballs. I don't ever have a chance to sit down and think about what I'm doing. It's always, whatever I have to do today to help us win, that's what I have to do. … The way I lead I think is more by example but I'm always talking to the guys in situations and stuff like that. Obviously I'm approachable. I'm always talking. I think guys probably want me to shut up but there's a lot of different types of leaders on our team that do it a certain way."
Varitek was most likely effective in his own ways throughout this process. But in this case, the approach could have used the complementary presences of people like former pitching coach John Farrell -- who would have offered a bigger brand of structure for the pitchers and, to certain degree, intimidation -- and Victor Martinez. While with the Red Sox, Martinez represented the gregarious sort of leader many have wished Varitek would have been identified as.
"One of the most common attributes in leaders is there is a tremendous authenticity in them," Cleveland Indians president Mark Shapiro once noted. "That is Victor."
That is also Varitek. He was who he was, and that never wavered. The Red Sox? That was another matter. That was another problem, one that even the captain couldn't fix.
The guys react to what Don Banks had to say and get into some more thoughts on Deflategate. Are McNally and Jastremski ever going to break their silence and give their side of the story? Price says yes ... eventually.
Don Banks talks with the NFL Sunday boys about his reaction to Brady's appeal, where we go from here and the NFL's motives and decisions throughout the process. He also gets into the Pats offseason so far and their weakness at CB. Don gives his take on the AFC East this year and how some of the Pats' rivals have improved.
Greg and Price discuss their thoughts on some of the reports that have leaked after Tuesday from Brady's appeal hearing. The boys talk about what the reaction will be if Brady decides to accept a 1-game suspension. Fans want a complete exoneration, but there's a good chance that they won't get that - how will they react? They also talk with Mike Petraglia and get his thought on the appeal and more.
How long will this rebuild take? How much money will it take to keep Bae Crowder? Are Draft Picks even worth anything? With the Danny Ainge not landing any big names in the draft, and unable to lure any big names in free agency, Sam and Ben discussed if the Celtics are doomed moving forward.
Sam is joined by Jared Weiss from The Garden Report and CLNS Radio to breakdown game 4 of Cavs-Warriors, preview game 5 on Sunday, and analyze the Celtics needs this off-season.
Greg Dickerson and John Tomase discuss the amazing season for the Celts and if they have any chance against Lebron and the Cleveland Cavs in a seven game series. If they do, HOW ... how do they get it done?
Joe & Dave talked to the Red Sox slugger, whose 7th-inning homer took the lead back for good in the win over the Astros at Fenway.
Joe & Dave talked to the Sox starter, who threw a much-needed complete game win against the Astros at Fenway Park.
Joe and Rob Bradford talk with Red Sox outfielder Alejandro De Aza about the Red Sox solid road trip and offensive outpouring in a win against Toronto.
Don Sweeney, who was hired as the Bruins general manager yesterday speaks with Dale and Holley about his new position and where the Bruins go from here.
The awesomely knowledgeable Fluto Shinzawa calls DJ, Naoko and Pete to talk about his thoughts on the future of the B's. He discusses his column from earlier this week on Cam Neely wanting to give Claude the ax earlier in the season but not getting the ok. Fluto shares his thoughts on Chiarelli's firing, the future for Claude and where the Bruins should go from here. He also gives his opinion on potential moves the team can make, who would fit in here, his thoughts on the NHL playoffs so far and more.
In the final hour of the "midseason finale" as DJ likes to call it, the crew discuss more about the future of the Bruins franchise, the possible power struggle in the front office and who should be the head coach going forward. They talk to intelligent and talented Fluto Shinzawa about all of these thing and more in an excellent interview, and finally, DJ says THANK YOU!
The guys discussed John Farrell's decision to start Porcello again.
The top stories of the day as recounted by Gary Tanguay.
Dino, Gary and Bradford discussed their holiday weekend.
David Ortiz hates the All-Star Game voting process. MFB and the callers try to come up with some alternatives.
We hear advice on how to avoid shark attacks. A couple of baseball-illiterate Irishmen offer some analysis. A firework enthusiast wins a Darwin Award.
The Red Sox won 2 out of 3 against the AL leading Houston Astros. Rick Porcello and his league-worst 6.08 ERA will face off against the Marlins on Wednesday, despite his continued struggles.
Nathans Hot Dog eating contest, Womens World Cup, and many many more...
The USWNT were redeemed by beating Japan at the World Cup. So we look back at some teams who redeemed themselves after losing to their nemesis.
In honor of the 4th of July holiday, guest hosts Rob Bradford and Andy Hart examine the four worst renditions of the Star Spangled Banner at sporting events.
WEEI Bruins Reporter D.J. Bean joins Mikey Adams and Lenny Megliola to talk about the signing of winger Matt Beleskey on the opening day of NHL free agency.
With 80 games played for the Red Sox, Mikey Adams wants midterm grades for several players. Also, after another Rick Porcello clunker in Toronto, callers and texters give unflattering Porcello Limericks. Lenny Megliola and Textress Lucy are along.
Danny's early thoughts on Celtics drafting Terry Rozier at the 16th pick
Dino, Sausage and Curtis recap their holiday weekends.
Ben, Russ & Alex discuss the Revs continued downfall & argue over The Mighty Ducks movie franchise
Ken Laird and Ryan Hannable are joined by special guests Mike Mutnansky of the Red Sox Radio Network and Red Sox minor league hitting coordinator Tim Hyers to talk Sox prospects. What do the struggles of Rusney Castillo and Rick Porcello in the majors mean? Also, the international signing period begins July 2, looking back at past Latin American signings. And June selections for affiliate players of the month
Greg Dickerson is joined by Super Bowl champ Steve DeOssie who presents the theory that Roger Goodell actually wants Tom Brady to appeal his suspension in court... and to win. Also, the guys defend themselves when a caller describes them as Patriots 'homers'.More from this show
Dino, Gary and Bradford discussed their holiday weekend.More from this show
The guys discussed John Farrell's decision to start Porcello again.More from this show
The top stories of the day as recounted by Gary Tanguay.More from this show
Gary and Ben on the Pats.More from this show


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Geological Formation Names of China (1866?2000)Springer Berlin Heidelberg 2010; US$ 1,559.00
This book offers the only catalog on stratigraphic nomenclature for China in the world with two writing types?Wade-Giles Romanization and Chinese Phonetic alphabet. It is therefore convenient for domestic and overseas readers. more...
Experimental and Natural Rock Deformation / Experimentelle und nat�rliche GesteinsverformungSpringer Berlin Heidelberg 2012; US$ 99.00
Ten years have passed since the last symposium on "Rock Deformation" was held in Los Angeles. The intervening period has seen striking advances in X-ray and experimental structural petrology. The Symposium of the Working Group on X-Ray and Experimental Structural Petrology, held at the invitation of the Deutsche Forschungsgemeinschaft on 17 and 18... more...
Explosion Seismology in Central EuropeSpringer Berlin Heidelberg 2012; US$ 99.00
Publication of the Deutsche Geopysikalische Gesellschaft more...
Random Processes in GeologySpringer Berlin Heidelberg 2012; US$ 99.00
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Potassium Argon DatingSpringer Berlin Heidelberg 2012; US$ 99.00
Dedicated to Wolfgang Gentner more...
Volcanic Landforms and Surface FeaturesSpringer Berlin Heidelberg 2012; US$ 99.00
THIS BOOK, conceived by N. M. S. , is patterned this atlas, namely to assemble into a single source after The Atlas and Glossary of Primary Sedi� book a photographic record of nearly all volcanic mentary Structures by F. J. Pettijohn and P. E. Potter surface features described during the development (Springer-Verlag New York, Inc. ). We introduce of... more...
Physics for Geologists, Second EditionTaylor and Francis 2002; US$ 164.95
All geologists need a broad understanding of science to understand the processes they study and analytical techniques. In particular, geology students need to grasp the basic physics behind these processes, which this book provides in plain language and simple mathematics. It gives the reader information that will enable him to ascertain the validity... more...
Energetics of Geological ProcessesSpringer Berlin Heidelberg 2012; US$ 99.00
Hans Ramberg is working in an area of geology where 60 years are a short, often negligible period of time. This is not so in the lives of men. For us it is a time for evaluating past accomplishments and a time for friends to express their appreciation and admiration. Some universities have become famous for this ability to foster eminent scientists... more...
Use of Proxies in PaleoceanographySpringer Berlin Heidelberg 2012; US$ 329.00
Paleoceanographic proxies provide infonnation for reconstructions of the past, including climate changes, global and regional oceanography, and the cycles of biochemical components in the ocean. These prox� ies are measurable descriptors for desired but unobservable environmental variables such as tempera� ture, salinity, primary productivity, nutrient... more...
Beyond El Ni�oSpringer Berlin Heidelberg 2012; US$ 99.00
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text: http://www.unix.com – I have a NAS and I upload my videos to it from time to time. the video format is 3gp but my media player PBO could only play avi. I want to copy these files to different directory and change the extention from 3gp to avi. (yes I want to keep the original version and create a duplicate version with different extention). Could anyone give me some hint which commands I should start to learn for this work. I want my arch linux to check the original folder daily for any newly added files. if there is any new files, then do the copy and change job. Thanks! (HowTos)


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Mars Landing 2012
Inside the NASA Curiosity Mission
(If any tax is payable it will be calculated and shown at checkout.)
moreNational Geographic presents the science, the goals, and the anticipation of humankind's most ambitious planetary expedition ever: the Curiosity mission to Mars. On August 6, 2012 (EST), NASA's Curiosity spacecraft will complete its 255-day, 354-million-mile journey and plunge down into Gale Crater, its target on the martian surface, decelerating from 13,200 to 0 mph in 7 minutes. The whole world will be watching this, the most complicated and precise landing ever undertaken, and wondering: What's the inside story on this Curiosity mission, and what do NASA scientists hope Curiosity will find? In this e-short, written by Washington Post science correspondent Marc Kaufman and published just as the suspense builds, with Curiosity hurtling toward Mars, space science readers, techies, and informed news junkies will find answers to these and other fascinating questions about the red planet. less
National Geographic Society; July 2012
60 pages; ISBN 9781426210938
Download in secure EPUB
Title: Mars Landing 2012
Author: Marc Kaufman
60 pages; ISBN 9781426210938
Download in secure EPUB
Title: Mars Landing 2012
Author: Marc Kaufman
Buy, download and read Mars Landing 2012 (eBook) by Marc Kaufman today!
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Build Better Sleep Habits
Many experts recommend cognitive behavioral therapy for the treatment of insomnia. CBT corrects the thought patterns and behaviors that can cause or worsen insomnia, with help from a psychologist. But many of the strategies can be done on your own. Here's how.
For seven to 10 days, track the time you get into bed, the approximate time you doze off and the time you wake up. Gathering this information will help you determine how much sleep you need and the best time for you to actually fall asleep. While you may go to bed at 10 p.m., you may not fall asleep until 11 p.m., which suggests that your circadian clock sets a later bedtime than you do.
"Sometimes, our desire for sleep has nothing to do with our own underlying circadian clock," says Helene Emsellem, MD, director of the Center for Sleep and Wake Disorders in Chevy Chase, Maryland, and author of Snooze or Lose. "Getting in tune with your circadian clock is the first step in understanding your insomnia.
QUIZ: Do You Have Healthy Sleep Habits?
Restrict Your Time In Bed
Once you've determined how much sleep you need, work backward to figure out your bedtime. For instance, if you need seven hours of sleep and get up at 7:30 a.m., you shouldn't hit the hay until 12:30 a.m. When you're able to fall asleep without long bouts of insomnia, you can go to bed a little earlier. But try to spend most of the time in bed actually sleeping. "Sleep restriction is based on the idea that time spent awake in bed is counterproductive," says Nancy Foldvary, DO, director of the Sleep Disorders Center at the Cleveland Clinic and author of The Cleveland Clinic Guide to Sleep Disorders.
Try This
Use a book lamp tonight to do your reading. Limiting the amount of light at night will strengthen your body's natural drive for sleep.
By limiting your time in bed, your brain learns to associate bed with sleep. The technique is also effective because it creates a mild form of sleep deprivation, especially in the beginning, says Donna Arand, PhD, clinical director of the Kettering Sleep Disorder Center, in Kettering, Ohio.
"The sleep deprivation makes it easier to fall asleep on subsequent nights and also begins to reduce awakenings during the night," she says. "This forces the sleep time to be consolidated. The body and brain soon learn to reestablish the connection of being in bed with being asleep."
Get Out of Bed
Lying in bed awake repeatedly teaches you to associate your bed with anxiety, which perpetuates insomnia. To break this association, get out of bed if you've been awake for 20 to 30 minutes. Do something monotonous like folding laundry or reading a book. "You want to take your mind off thoughts about not sleeping, but you don't want to do anything that will activate or arouse the body or brain," Dr. Arand says.
Once you feel sleepy, go back to bed. If you're awake 20 to 30 minutes later, get up again. Repeat the process until you fall asleep. "This technique works because of the conditioning effect," Dr. Arand says. "It also reduces the stress and anxiety that occurs when people are lying awake in bed."


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Date posted: April 29th, 2015
Like Autumn leaves and student loan debt, IMPROVment will return in the fall.
Stay up to date with our schedule by subscribing to our Google Calendar, audition info can be found over at the Audition page, and of course you can always find the latest updates, photos, and extra performance information on our Facebook page.
Date posted: April 26th, 2015
Come out to IMPROVment's special End of Year show! We've got some very special surprises waiting for you, including the return of a game we haven't played in years! Come out to the Black Box this Monday, the last day of classes, at 9pm to see it!
Check out our Facebook event for more info!
[…Read more]
Date posted: March 30th, 2015
Thank you to everyone who came to our 4th Annual Lake Effect improv comedy festival! We all had a great time performing with the visiting troupes and we hope you enjoyed all of their performances! If you'd like to find out more about the other troupes that performed at the festival, Like their Facebook pages below. For upcoming IMPROVment performances, check out our calendar here, and we'll see you all next year for the 5th Lake Effect Festival! […Read more]
Date posted: March 22nd, 2015
The 4th annual Lake Effect improv comedy festival is this Saturday, March 28th at 7pm in the Tinkham Veale Ballroom! Come prepared for 2 hours of great FREE comedy as well as FREE FOOD during intermission and DISCOUNTED DRINKS at the Jolly Scholar following the show. This year's festival features troupes from OSU, Oberlin, and Bowling Green State University. Check out the Festival page for more information.
Date posted: February 22nd, 2015
On Friday and Saturday, Feb. 20th and 21st, IMPROVment was excited to attend The Tides Improv Comedy Festival hosted by Fishbowl Improv at The Ohio State University. Friday night featured short-form groups from all over Ohio while Saturday focused on long form style. Saturday also featured several professional improv groups from New York City and Chicago. A big thank you to Fishbowl Improv for putting together an amazing festival and allowing our super fun trip! […Read more]
Date posted: February 11th, 2015
Bring your significant other to Eldred Black Box on Friday the 13th at 11pm for what will surely be a touching and gruesome event! We'll play special romantic games with interspersed horror fit for such an unlucky day! (There might even be some free treats for the audience!)
Be sure to see Lobby Hero first, playing on Eldred Main Stage at 8pm. Visit theater.case.edu for more info.
Date posted: January 31st, 2015
It's exactly what it sounds like. We're very exited to present our newest harebrained scheme. What would happen if an improvisor only had one life to give in a show? Join us at 9 PM in Eldred Black Box to find out…
Date posted: January 7th, 2015
Welcome back! Please take some time to peruse our brand new website, including our new calendar on the right; you can subscribe to it so that our show dates automatically appear in your Google Calendar! You can also find a link to our Facebook at the bottom of the page where we also post updates.


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Chapter Thirty-One
A Song And A Ribbon--Part Two
Farkas followed the path down, trying to trace the source of the singing. Finally he spotted a red-haired woman, standing with perfect posture on a shelf of rock across the little glade. Her song grew softer after a moment, as she became aware of his presence. It ended on a piercing soft high note that seemed to penetrate his heart and belly with a sweet longing that sent shivers up and down his spine, then it was gone, leaving only the music of water, bird, and wind.
She turned to face him fully when she was done listening to the last echoes of her song. Vivid red hair was braided loosely around her face, framing a face as pale as freshly carved ivory. Farkas struggled to keep his mouth from gaping open like a fool, because in this light she was the most entrancing thing he had ever seen, wrapped in her long cloak, looking down at him with a curious expression, seemingly floating in the light.
He would have stayed and stared happily at her until the sun set, but a growing alarm in her expression told him he needed to say something. Anything at all to make her relax once more, and smile maybe. Conscious of his rough, gravelly voice suddenly, he cleared his throat and said, "Wow! Lovely. The song I mean, it was something else. Truly lovely. So, ahh, Laure wanted me to make sure you were okay, fetch you up in case you might be hungry. There is food. To eat. Up." He clamped his lips shut then, aware that he was reduced to idiotic monosyllable words. Not caring to embarrass himself more in front of this woman any more than he had already, he waited for her reply while trying to steady his breath.
She smiled sweetly and looked away shyly. It was as if he had seen the rising sun for the first time, and he gulped quietly.
"Thank you," she said in an accented voice as melodious as her song. "I am Autumn, and you must be Vilkas' brother. You have the same face."
"Farkas. I mean, I am Farkas. Vilkas is my older twin." He walked over to her ledge and held out his hand. "Come on down from there, and I will show you the way. Laure won't want you falling and breaking your neck."
She took his hand and clambered down. "She must think me a clumsy idiot by now."
"Nah. Laure--she just looks out for people. Her people."
"It seems that she does go beyond the common kindness."
"Every day. Nice to meet you, Autumn."
"Well met, Farkas."
They started across the narrow glade at the bottom of the cavern, walking quietly for a few moments before Farkas asked, eager to hear her speak once again, "So, are there words to the song you were singing? I would like to hear them someday."
"Someday I hope there will be. I just felt like singing when I came in here, and that was what came out."
"Wow, you have a gift. I could never do that. Just make up a song. At least nothing anyone would ever want to hear.
"Thank you, that's very kind." Autumn found herself blushing furiously, glad that Farkas was walking ahead of her and couldn't see her flushed cheeks. She always turned a horrid pink when she blushed, and for some silly reason she hadn't figured out yet, she didn't want this giant of a man to see that if she could help it.
He helped her up a few steeper spots, then ushered her to the top with a hesitant smile.
She liked the way it softened the hard lines of his face, made his fierce expression friendlier and more welcoming.
He called out, "I found the songbird, Laure. Even brought her in one piece." He gently nudged her into the spread out crowd, where Laurelin was waving and patting the ground near her.
"Autumn, come sit and refresh yourself. Meet my family!"
Later, Autumn found herself studying the diverse group of people all around her. There were more itty-bitty Bosmer than she had ever seen before, plenty of Nords—which was comforting--and there were even two Dunmer Companions and one pretty woman that she supposed was some sort of Imperial provincial. All seemed to be getting along well, and indeed were sharing meat and mead as if they were fast friends. She also supposed that the common factor in this harmony was due largely to the Dragonborn.
Before she thought about it in any depth, she turned to Laurelin and suggested, "Why not have the wedding here? There is a sense of peace and sanctity here, as well as the astonishing beauty, and you have your whole family with you right now!"
Laure stopped laughing at whatever clever thing Aheia had been saying to choke on a crumb of cheese. She waved off Vilkas' solicitous attempt to to pat her on the back, wheezing softly until her cough subsided. She wiped away involuntary tears and chuckled at herself, shifting uneasily on the ground.
"Ah, hem—that is an interesting idea; I hadn't thought of that. Remarkable notion, Autumn. Your idea has merit; of course, Vilkas would need to agree as well. We are also without a priest to officiate." She studiously avoided looking his way, until he bumped her with his shoulder.
"I like how you think, bard, but I won't pressure her into anything she isn't ready for," Vilkas said to Autumn.
"I'm sure someone here is qualified to officiate over a simple tying of the knot," observed Belarym helpfully. Aheia nodded with a wide smile.
Farkas smacked his knee and remarked, "Sounds like a fine idea to me, Laure. The little songbird is right—all your family is here, and your shield-siblings too."
"You could think of it as practice for the big one in Whiterun. Or a secret wedding that only we will know about!" mused Ria.
Laure stood and wiped the leaf litter from her backside, suddenly conscious of the intense scrutiny of everyone around. "Pardon me, I would like a moment alone please. I won't go far." Indeed she simply turned and scrambled high into the branches of the Eldergleam. She found a likely branch and walked along it until she was given a choice view across the cavern. She sat down, draped easily in a comfortable crook and stared thoughtfully out, barely seeing.
Truth be told, I'm not ready to make that leap just yet. As in right now! She had been mentally girding herself up for the ceremony in Whiterun. Somehow that day was important for her peace of mind and comfort with the preparations she had made. She had even found herself enjoying the process. Not that I'll ever admit that to Vilkas or anybody else. Throwing parties was fun, and she truly loved Vilkas, and was ready to marry him. In a week. But today?
She tried to order her thoughts, but they tumbled about, untamed. She recalled how she had wished for a more intimate affair, before Lydia's bright idea to invite everyone. A small ceremony with only those few people she really cared about present. She sighed and rubbed her eyes.
"Nisi," she called down eventually. "Please, will you join me up here for a moment?"
"Certainly, Mother. I will be right up!" called her eldest daughter. Soon the soft rustling of leaves and blossom announced her arrival.
"This is amazing, Mother. It is so peaceful, so serene here." Nisinah eased herself down and slipped her small hand into her mother's. She didn't fail to notice how tall and spare of flesh she had grown since their last visit in Valenwood. "Did you wish to speak with me about all that business down there?"
Laure nodded but didn't trust herself to say anything, so remained silent. Nisinah ran slender fingers over the bark of the Eldergleam, feeling it's life pulsing beneath her hand, thinking quietly herself for a few long moments before saying quietly, "If you are truly sure you wish to join yourself so permanently to Vilkas, what harm is there in doing it here, in such a beautiful place?"
Laure fidgeted a moment before answering. "I do not have anything against the idea, in and of itself. I am actually rather fond of the idea. Clever girl, that bard." She smiled ruefully and settled back once again.
"Are you positive you are ready to take this step, Mother? You know what you are committing yourself to? Losing Father was nearly unbearable for you. In truth, how much longer will you and Vilkas have together? He isn't a sapling anymore, and humans have such short lives in comparison to ours." Nisi turned her wide, black eyes on her mother and looked deeply into the icy blue pair facing her—searching for doubt or fear. She wasn't sure she was happy or disturbed that she found neither, only determination and excitement.
"Oh absolutely, I know what I am committing to. And I am not worried so much anymore about how long we have together. I'll love him every day of our lives and cherish them all. Aye I want to marry Vilkas; it isn't that. I was prepared for it to happen next week. It is more that this is unplanned; I had a list, you see."
Nisi blinked slowly and squeezed her mum's hand. "Ah, well if you are not ready yet, I will stand with you."
"Does a week make so much difference, Nisi?" Her daughter shrugged and shook her head. Laure took a deep breath and held it a long moment, then pushed it out. With it she mentally pushed out the last lingering doubts or worries. She had a marvelous opportunity here, with her shield-siblings already in attendance, in one of few places she thought grand enough for such an absurd spectacle as her wedding, and to really make it complete, beyond all hope or planning, her kin were here as well. She glanced up at the magnificent tree suspiciously. It was considered to be sacred to Kynareth, and that goddess had already proved she wasn't above tampering with her life.
A burst of laughter from below brought her back to the present situation. "Thank you, sweetling. I have been given many kogaan, many blessings today. Do you think Vilkas will agree?"
Nisi laughed brightly. "I think he would do whatever you asked him to do."
"He's such a good boy," Laure murmured, her lips curving up in an impish smile.
"So you are going to do this today, truly?" When Laure dipped her head in affirmation, Nisinah gestured toward the ground below where everyone waited. "Do you need a moment, or do you feel like just plunging in?"
"Headfirst and worry about how deep the pool is when we get there."
"That's the spirit, Mum. Do you want to tell them?"
"We will both go, aye? No sense in wasting daylight. We could be half way back to Whiterun by bed time if we hurry."
* * *
Laure and Nisinah dropped lightly from the lower branches of the Eldergleam and walked over to the group, both grinning broadly. Vilkas looked at his intended and gave her a slow nod, having heard all, and held out his hand.
Laure took his fingers and gave him a matching nod, then turned to find everyone watching raptly. She cleared her throat and called out, "So did you all need a formal invitation, or can we dispense with the formalities as soon as we find a cord or thong?"
Everyone shouted and stamped their approval, the noise sending a flock of startled birds winging up to the heights of the cavern, where they wheeled and darted, adding their own cries to the tumult.
"Okay then," said Laure, barely heard. Her oldest granddaughter, Lyric, walked over with something rolled up in her hand. "What's this, sweetling?"
"It's one of my old hair ribbons. I thought you could use that to tie your knot. If you like it that is. I think you might because you gave it to me when I was little."
Laure unrolled the ribbon and admired it's embroidered green vines, with tiny flowers that resembled blue stars. She recognized it very well. Slightly frayed at the edges, well worn as Lyric had carried it around for decades. "This will be perfect; thank you, darling one."
Farkas squeezed up near Laure and his twin and asked, "May I do the honors? You know I am not always the best with words, but I would like to say a few things."
Laure and Vilkas both agreed readily and handed him the ribbon, because all of a sudden there was a general buzz of energetic preparation happening that was nearly overwhelming for a few moments—then it all stilled as quickly as it had begun. Packs had been stowed out of the way, and a broad semi-circle of friends and family formed in the dappled shade around Laurelin and Vilkas, standing sheepishly in the center, hand-in-hand.
Farkas solemnly examined the ribbon in his big hands, then cleared his throat. "Most of you know I am not one for fancy speeches. I won't try to change that now. I just want to say that, I love my brother, and I have always wanted him to be happy, and to have the finest of all things in life. For a while I thought that glory earned in battle and riches in our pockets were the finest things in life. Dying a glorious death with a sword in hand seemed to be the only thing worth living for. These are the things I wanted for my brother. I can not say whether having any of these things gave my brother any true happiness. Then we all met Laurelin. She is a shield-sister to us first and above all other titles or stations. We know that she will have our backs when it comes to any situation. She has shown us what to do with our skills, how to aim them so that we can help those who need it. And she has shown us love, and how to be thankful for what we have, and how to live this life well, not just in hope of a happier afterlife. Most importantly though, she opened her heart to my brother, and they have helped heal each other in many ways. I know they will irritate and infuriate each other, yet I have seen them overcome incredible trials together. Now they are formalizing their bond, hopefully with the blessings of everyone present. May all the gods bless their life together."
Laure chuckled quietly. "Indeed, at the moment, a few of them can hardly keep their fingers out of our lives. Meddling with our dreams . . . filthy trick."
"Hush dear," chided Vilkas softly. "Did you want to say something for the group or shall I?"
Feeling just a trifle light-headed, Laure looked Vilkas straight in the eyes and told him evenly, "I had a plan. I was rapidly approaching my goal of being the wealthiest mer in northern Tamriel when this Dragonborn business was dropped on me without warning. All my careful plans were ruined. I certainly never counted on meeting you. Was it fate or chance that brought me to Whiterun, broke and in shock still, to encounter the infamous Companions for the first time? Whatever the cause, I am incredibly grateful to have you in my life now. Finding you reminded me that wealth is not everything. Being rich could not purchase what I have with you. In you I found everything I had been unconsciously searching for all these years. With you I feel safe and warm; even when we are apart, I feel that warmth. I look forward to seeing you again as soon as we part. I love hunting with you; I adore snuggling up with you and a good book. I love the way you say my name and never shorten it. I love your honesty and patience with me, even though I know it hasn't been easy. You stayed with me through rough times, and we aren't quite through it all yet. I believe the end is in sight, though, and once we get passed these last few minor obstacles . . . then, well, who knows what we will come up with? All I know is that today, I look at my very closest friend, my love, and know that I want to marry him with all my heart, and fill our home with happiness!"
Laure paused, then gave Vilkas a sly look. "Will that suffice?"
Vilkas gave a theatrical shrug. "Not terribly romantic, but you did have to come up with that on the spot. I hope your vows for the other ceremony will be properly poetic and tear-inducing."
"I'll start writing them as soon as we get home. Did you want to say anything? Try not to make me cry though, my face puffs up horribly when I cry."
"I suppose I could recite poetry to you, compare you in verse to the marvels of the world. I could liken you to a flower, or the sky at dawn. Infinite comparisons come to mind. But what I want to tell you is this: I underestimated you from the first. When you first walked into Jorrvaskr, all I saw was an underfed elf in borrowed armor. I couldn't see the strength and beauty in you—not yet, at least. When I took you out for your first testing, I wanted you to fail, because I thought you were just going to be a waste of my time. And I was angry that Kodlak was apparently in favor of you joining. But when you tried to punch my, ah, groin, you got my attention."
There was a ripple of quiet laughter at that from the small crowd, but it hushed quickly, allowing Vilkas to continue.
"Had I known how very wrong I was, I would have let you punch me there and then, and perhaps gained that much more time with you. As it is, I stand here in front of you, and my heart is pounding, my knees feel like water, just from knowing that you love me, that I love you, and we will have the rest of our lives together. I no longer see you the same way; now I can perceive the strength and courage, the loyalty and divine beauty that fill you so full that those near you are blessed with a share, themselves. I could probably recite your praises for hours, probably have when I was in my cups."
"Oh, you have," said Farkas emphatically, but smiling his amusement.
Vilkas continued, apparently choosing not to pay attention to his twin. "Laurelin, I love you with all my heart, and though I have little to offer you, I make this vow. Though the sky may shatter and Oblivion take all else, I will stand by your side, and only the gods themselves will part us."
"That will do nicely, love. Don't overdo it now."
"Why thank you, love. I was finished, actually. My speech for the big ceremony is already composed and polished up nicely." He paused a moment thoughtfully then exclaimed in mock recall, "Isn't there supposed to be a knot-tying somewhere in all of this?" They both turned and looked at Farkas expectantly, hands clasped tightly.
Farkas, holding the ribbon still, glanced from his brother to Laurelin. "You ready for this then?"
Vilkas gave his brother a long, steady look and said, "Aye. You, more than any, know I am." He then waited for Laure to meet his gaze.
She held his hands tighter and winked. "Oh aye, I'm quite ready if you are."
Farkas let out a deep breath, as if he had been holding it his whole life. He took the ribbon and looped it deftly around the couple's wrists while saying, "Well then, with no particular authority excepting that given me by these people gathered, and hopefully with the blessings of all the Gods, I bind you, Vilkas and Laurelin to each other for the rest of your lives as husband and wife. Protect and love each other, laugh and fill your home with joy. Hold each other up in times of weakness and sorrow, and never forget that which binds you is not this ribbon, nor duty. Remember always the love and devotion you have for each other, for those are but a few of the things which make you strong together." Farkas finished tying the knot with a small flourish, then announced, "I name you husband and wife, Vilkas and Laurelin. Brother, would you like to kiss your bride?"
"I thought we would never get to that part!" Vilkas exclaimed as he wrapped his free arm around Laure's waist. He pulled her to him, their armor making muted screeches and crashes as dragonbone slid against darkened steel, the functionality of their armor contrasting sharply when their lips met with almost shocking tenderness.
As the kiss drew on and deepened, Farkas chuckled quietly. "About time, you two. Now, we celebrate with some mead and a few songs, I say!"


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A chill in the air calls for good coffee and warm coats and that's exactly what I found Tess with at the new Westside Acton park. The Betts store manager and Uni student was out to try Damn Fine coffee for the first time. I quickly learnt about Tess that she loves her coffee! Tess had combined her cool street style to perfectly match the cooler weather with a gorgeous black coat over a grey sweater (both from Sportsgirl), Neuw blue denim ripped skinny jeans from Parliament, black flats from Betts and Deena and Ozzy oversized bag from Urban Outfitters.
Melissa Daniels was style stalked at the Rebel Muse media launch this past week.
The 29-year-old Executive Assistant effortlessly wore head-to-toe Witchery, literally, from earrings to shoes!
This outfit was perfect for the Rebel Muse launch. Melissa looked smashing in this khaki animal print dress - the outfit was polished yet fun and the purple Nars lip pencil provided a chic pop.
Melissa said her style in general has taken a rather grandiose step towards simplicity over the last few years. The staples in her wardrobe have gone from big and bold to comfortable and chic.
We love!
Janette Lenk - The Fashion Vault.
We spotted 18-year old uni student, Tilly, spending her holidays studying hard at the library. On a chilly Canberra day, Tilly opted for warmth and comfort. Dressed in all black, she said her Op Shop denim jacket is usually her go to piece in winter.
Tilly has a quality-over-quantity attitude. Being a bit of a tomboy who doesn't go shopping often, she believes that good quality basics are key. Her black jeans are from Wrangler and her leather black shoes are from Wittner.
Her op shop jacket is the star of the outfit and is a must for everyone's wardrobe.
Autumn is a great season for trying out new trends. We are looking forward to blending shades with pops of colour and out-there patterns.
The colour of Autumn and Winter 2015 is definitely grey, followed by black and white. Staples and basics are huge with even more of a need to stock up on good quality items which can be worn everyday and layered (we love layering!) with larger in-the-moment 'trends'. Think a really great good quality pair of boots and a leather handbag.
Pops of colour and prints are always in-season - just the trendy colours and styles change each year. Neons are definitely 'so 2014' so please wear these items with extreme care. We'd suggest they should be worn only to the gym or under your outfit and once they fade it's time to say goodbye (read: put them the Vinnie's bin as soon as possible).
We love this week's Street Style because the basic cotton shirt gives the loud patterned skirt a casual feel, while the handbag and ankle boots play up the look for on-trend style points.
Tommy was pulled to the side by us on his way to afternoon drinks - his outfit being the reason why.
With Canberra's temperatures dropping fast, Tommy opted for both style and functionality with his maroon blazer as the 'statement'. However, he has created an effortless overall look - keeping the outfit light and 'smart-casual' pairing it with a classic v-neck white tee, cream chinos and tan shoes. Very appropriate for Autumn.
It's refreshing to find a man in Canberra who enjoys shopping and dressing sharp.
Outfit breakdown:
Blazer: Zara
T-shirt: Asos
Pants: Zara
Shoes: Aquila
Deejay - The Fashion Vault
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Disney Stars Reveal Fourth Of July Traditions
Matt Damon's Ponytail
Jon Bernthal
'Magic Mike XXL': The European Premiere
Taylor & Calvin's BBQ Bash!
Diddy Avoids Felony Charges
Tiffani Thiessen's Baby Boy!
'Wet Hot' Trailer Drops
'Ten Thousand Saints' (First Look)
Dennis Dunaway Releases Memoir On Alice Cooper Group Adventures
Kelsea Ballerini: Access Breakthrough
Dance Moms' Goes Hollywood
MyHabit Style Finds
Kim Slams Embryo Rumors
Nicole Trunfio's Quest To Normalize Breastfeeding
Nicole Trunfio Defends Breastfeeding ELLE Cover
Nick Jonas On Music Success
Mira Sorvino's Fight To End Human Trafficking
Bryan Safi On Being Part Of 'Surreal' Project 'A Deadly Adoption'
April 21, 2011 06:47 PM EDT
Do not anger Mother Monster!
Lady Gaga shocked her acceptance-loving fans this week when she described accusations of plagiarism against her hit, "Born This Way" as "retarded" in a recent interview with NME magazine.
Now, the chart-topper has apologized for her seemingly insensitive remark.
"I consider it part of my life's work and music to push the boundaries of love and acceptance," Gaga said in a statement released to Perez Hilton on Thursday. "My apologies for not speaking thoughtfully. To anyone that was hurt, please know that it was furiously unintentional.
"An honest mistake, requires honesty to make," she continued, before ending the statement with a line from her platinum anthem, "Whether life's disabilities, left you outcast bullied or teased, rejoice and love yourself today."
In related news, the blond chanteuse has granted Weird Al Yankovic permission to release his "Born This Way" parody, "Perform This Way."
The comedic musician posted the audio to his parody on YouTube on Wednesday – which includes lyrics such as, "Got my straight jacket today, it's made of gold lamé, no not because I'm crazy, I perform this way!" — along with a message stating the spoof would not be available on his next album, as Lady Gaga refused to approve it.
Mere hours later, Al revealed in a blog post that there had been a mix-up.
"Apparently the fact that she didn't approve it was news to Lady Gaga herself! Gaga's manager has now admitted that he never forwarded my parody to Gaga – she had no idea at all," Al wrote in a blog titled, "Gaga Update!" on his personal website on Wednesday. "Even though we assumed that Gaga herself was the one making the decision (because, well, that's what we were TOLD), he apparently made the decision completely on his own.
"He's sorry. And Gaga loves the song," he added.
Copyright 2015 by NBC Universal, Inc. All rights reserved.This material may not be published, broadcast, rewritten or redistributed.


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One taken to hospital after domestic altercation
A Lawrence woman was taken to a Kansas City area hospital Sunday morning following a domestic altercation. The woman was transported via air ambulance.
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Originally written on Fox Sports | Last updated 10/3/12
When you casually reviewed the Thursday night schedule at the end of the preseason, I'm fairly certain that you whizzed right past this Week 5 matchup between the Rams and Cardinals. Sure, you were looking forward to tracking potential Larry Fitzgerald points. You certainly weren't anticipating a matchup between an undefeated Arizona squad and a 2-2 Rams squad under Jeff Fisher. Let's set the table. The Cardinals won three of their first four games by four points or fewer, adding a blowout home win over the Eagles for good measure. The Rams eked out narrow wins over the Seahawks and Redskins by a combined nine points, narrowly lost to the Lions in Week 1 after leading much of the game and fell in an uninspired game against the Bears in Week 3 by 20 points. Now that you've caught up, it's time to assess the Week 5 opener. On paper, it's a fantastic matchup for Ryan Williams of the Cardinals. The Rams have allowed 130 total yards and 1.25 touchdowns per game to opposing running ba...
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APB do a little roof topping while out in Asia last year.
The Airplane Boys In Hong Kong (Video)
OG Maco - "Movies"
From the debut OGG mixtape, which dropped today.
Watch Marion Write's Documentary 'The Message'
Watch the process behind the making of the Las Vegas emcee's acclaimed album Black Gold.
JohnNY U. - "Thought You Knew" f. ScienZe & Dom O Briggs
The #WDOPEradio Series.
Lucki Eck$ - "Birdgang" (Video)
Produced by Eck$ (off X, out now).
Joe Swisher - "Under The Radar" (Video)
Grab The Swisher Suite EP inside as well.
Hus Kingpin & SmooVth - Splash Brothers (FreEP)
Roll with #TheWinners.


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Ava Garcia Model
Heather CrumleyModel Female Auburndale, Florida, US
Mayhem # 2700527
About MeHey there! I've been doing the modeling thing for a few years now. I'm wanting to up the ante a bit and start doing more serious work. As a Mom to a 1 year old and following my husband around the country with his job, it's hard to set up dates to shoot. I'm also a graduate of the John Casablanca program in Tampa, Florida.
Ava Garcia Model
Photos by Nathan W Photographer
Smartphotog Photographer
Performing Light Photographer
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Duke Morse Photographer
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Daniel Bryan announcement
The tense and heartwarming YouTube video, where Daniel Bryan teases the WWE Universe about a potential retirement before surprising everyone by announcing that he will be making his return at the Royal Rumble.
December 29, 2014
Daniel Bryan retiring
A cryptic Twitter post from Daniel Bryan that suggests the former world heavyweight champion could be announcing his retirement from WWE tonight on Monday Night Raw.
December 29, 2014


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"I would like to thank everyone for the love and concern shown during my mother's funeral. I was so pleased with her appearance - she was beautiful and restful and that is how I want to remember her - Thank you for your kindness."
We have a complete pre-planning checklist to be certain no detail is overlooked. The following are some of the items that are included on the checklist.


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Make Hey While the Sun ShinesHardback
List price $28.24
You save $5.43 19% off
Free delivery worldwide
Dispatched in 3 business days
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- Publisher: HARDIE GRANT BOOKS
- Format: Hardback | 152 pages
- Dimensions: 226mm x 230mm x 26mm | 862g
- Publication date: 1 January 2013
- Publication City/Country: South Yarra
- Illustrations note: colour illustrations
- Sales rank: 18,679
Product description
The crafty Pip Lincolne is back with her third book of sweet and whimsical projects. In "Make Hey While the Sun Shines", she shows you 20 gorgeous things to make whatever your craftiness! There are bike seat covers made from vintage fabric, crocheted baubles to decorate your house (or car!), hand-printed gift bags and pretty decals to customise plates or mugs. More adventurous crafters might like to try the deer quilt (in either couch or cot size) or the handy bottle tote to store your drinks when you head out for the day. Making hey isn't just about sewing and craft though - there are also 5 pull-out recipe cards with delicious goodies to take on a picnic or just enjoy at home. All of the projects have step-by-step instructions and illustrations to guide you through, and with comprehensive sections on sewing, crochet and knitting basics, "Make Hey While the Sun Shines" is perfect for anyone who is interested in handmaking their own beautiful things.
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Pip Lincolne grew up in a DIY family. Her dad sewed her lovely dresses; her mum made her orange sorbet; her brother fashioned little houses for her dolls; her sister drew and her nanna knitted, sewed, baked ... you name it! Raised on such handmade fare, there was never any doubt that a crafty life lay ahead. Pip lives above her popular craft store Meet Me at Mike's, in Melbourne's Fitzroy, with her lovely family.