text:
5 rules for a happy marriage
Getty Images/iStockphoto
Recently while at our favorite restaurant, the waitress asked how long we had been married. We told her 25 years. Her response was, "Wow, you still have that look in your eye." We laughed and have since had several discussions with her about marriage and what makes one successful.
Although each marriage is unique and comes with its own set of difficulties and trials, there are some basic rules that can help make your marriage not only succeed, but thrive.
Rule 1: Unity.
In Genesis, it says this of marriage, "Therefore shall a man leave his father and mother, and shall cleave unto his wife" (Genesis 2:24). The verb "to cleave" has multiple meanings. The one used in this scripture is "to adhere closely, cling, to remain faithful." This unity should apply to a couple's faith, their family and their goals. As Abraham Lincoln once famously quoted from Matthew, "a house divided against itself shall not stand" (Matthew 12:25).
This is not to say there will be no disagreements and disputes. As a couple, you need to address those and come to a consensus on how to proceed. Contention can breed discontent and pull a couple further apart. Work out your differences and find that common ground.
Rule 2: Be positive.
At one wedding, the officiator compared marriage to a highway, and then counseled the couple that there was no need to stop and examine every pothole along the way.
It is easy to get caught up in the things that go wrong. We have a favorite saying we tell our children when we think they are getting too negative, "Your negative vibes are bringing me down, man." Although we do it in jest as a means to lighten the situation, the truth is, constant harping on the negative aspects of anything is going to make any other situation look better.
Kay Moore, a marriage counselor in Raleigh, North Carolina, shared the following, "When a couple comes in for counseling and all they can focus on is the negative in the relationship and the other spouse, I know they will have a hard time making that marriage succeed. They need to get out of that train of thought."
Rule 3: Remember the past, enjoy the present and look to the future.
Take the time to reminisce together on your courtship, how you fell in love and all your happy memories as well as those that strengthened you as a couple. When my husband and I look back on all the roads we have traveled, we have been amazed at how we have grown closer to one another — even through the tough times.
Enjoy where you are in life now. Sometimes it is easy to dream of how it was before children and those responsibilities as well as dwelling on how it will be better in the future. The movie, "The Dead Poet's Society," introduced many people to the Latin term, "carpe diem", which means, seize the day. The point was to enjoy the here and now because soon it will be gone.
My husband and I love to talk about what we want to do when we retire. We dream of living near the beach or a cabin in the mountains; traveling the world and looking for what we call "the colorful places" which make this world such an interesting place. As a couple, take the time to dream. Looking to the future helps you invest the time and effort to make those futures come to pass.
Rule 4: Have charity.
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First established by Benjamin Franklin in 1775, by decree of the Second Continental Congress, the United States Postal Service is one of the oldest institutions in America. However, the city governments of San Francisco, Newark and New York recently signed on to provide paperless municipal mail through Zumbox instead of using the postal service.
Since the advent of email, mobile texting and other forms of digital communication, use of "snail mail" has become slightly inefficient and wasteful.
To produce and process 4 million tons of junk mail a year, 100 million trees are destroyed and 28 billion gallons of water is wasted. Also, $320 million of local taxes are spent to dispose of junk mail each year instead of providing parks, libraries, health care and other valuable services (41pounds.org).
In addition, municipal mail accounts for a staggering amount of postal transactions. In New York City alone, 15 million pieces of mail from the City are sent out on a typical day (MNN.com).
As a solution, some have pointed to paperless mail options like California-based Zumbox, which replaces your physical mailbox with an official inbox for your residence's address.
From the official website: "Zumbox is the world's first and only paperless postal system. The company has created a web-based platform for the delivery of paperless mail. For every U.S. street address, there is a corresponding digital mailbox – a Zumbox – enabling mail and other content to be sent as digital files and received online with no paper, printing or postage, and no scanning. Zumbox represents a more cost-effective and environmentally responsible way to send postal mail."
Supporters of this decision in each of the three cities hope that citizens will now have a chance to experiment with the Zumbox software and discover how easy and secure it is to use. Eventually, advertisers may also switch to this type of service, which can offer precise geo-targeting and analytics for marketing while stil drastically reducing the need for paper and postage.
Read more: conservation, digital mail, environment & wildlife, paperless mail, trees
Image Credit: saysomethingfunny.files.wordpress.com
Thanks Beth.
Thank you for info.
Thank you for info.
Thank you for info.
Thank you for info.
Interesting, thank you.
I can print my mail only when needed.
Credit cards encourage holders to receive their bills via internet saving on paper.
Just a few points of clarification: No one is being forced to use Zumbox. It's a choice by everyone. If you don't have a computer, continue to get paper mail as you do. You could even get both paper and paperless in parallel. That is your choice with Zumbox. In which case you wouldn't have to be home to get your mail. You can access from any computer.
With regard to USPS jobs, Zumbox is not going to eliminate the need for the USPS any more than FedEx did. Zumbox is a digital alternative...not a replacement. There is no way to replicate a hand-written letter on personal stationery. That said, the USPS must become more efficient regardless of the presence of Zumbox, online billing, and e-mail for that matter. All of these electronic mediums put pressure on the USPS.
Zumbox provides bank-level security and privacy. If you are comfortable with online banking, you'll be comfortable with Zumbox. If not, then it's your choice not to use the service.
The bottom line is that Zumbox can significantly reduce the environmental impact and waste of needlessly sending paper mail to those who do have computers and who are comfortable with online banking. 150 million trees per year are consumed by USPS mail. Paperless mail can mitigate some of that.
I work in retail and find there are people who don't have home computers (or computers at all)only work computers, so they need their ads by "snail mail".The print up ads to people get people into the the stores to buy products.These products woul not be seen by those people who don't have computers. It is a vicious cycle.
Disclaimer: The views expressed above are solely those of the author and may
not reflect those of
Care2, Inc., its employees or advertisers.
Darlene check this picture out @ DOT-111 tank car - Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/DOT-111_tank_car Two…
A couple of years ago somebody dumped their goldfish at a local small 'lake'. The herons had no trouble…
I have never travelled with any of my pets and do not intend to either.

subset: commoncrawl


text:
1862 25C PR67 Cameo NGC....
2009 January Orlando, FL FUN Auction #1121
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Gorgeous PR67 Cameo 1862 Quarter1862 25C PR67 Cameo NGC. Ex: Eliasberg. Astonishing quality for this low mintage Civil War date with only 550 proofs struck. Brilliant throughout, the design elements are completely articulated on each side, and the fields show unfathomable depth of reflectivity. Contrasted against the fields are the frosted devices that give this splendid proof its cameo effect. An impeccable pedigree that stretches back to 1894.
Ex: Eliasberg.
Ex: Eliasberg.
Ex: William Dickinson Collection (Henry and S.H. Chapman, 3/1894); J.M. Clapp to John H. Clapp; Clapp Estate to Louis E. Eliasberg, Sr., 1942; Eliasberg I (Bowers and Merena, 4/1997), lot 1479; J.B. Worthington Collection (ANR, 5/2005), lot 210.
From The Scott Rudolph Collection.
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The Top 10 In Action Sports
01Brick By Brick: Camping Lego Style
02Booze and Bikes: 14 Tours That Let Combine Two of the Best Things in the World
03Who Needs Hollywood? These Incredible Videos Were All Filmed on the Simplest Cameras
04Sam Pilgrim vs. The World: The Champion Aiming To Reclaim His Crown In A New Era Of Biking
05Eccentric Adventures Episode 2: Britain's Most Brutal Illegal Event is All About Cheese
06A Journey Into Darkness: We Went Mountain Biking in the Abandoned Mines of Slovenia
07After the Apocalypse: Inside The World's Most Breathtaking Ghost Towns
08Debate: Let's Stop Hating On Parents Who Want To Raise Adventurous Kids
09Guns, Roses, And Eating Insects: Adventure Cycling in Vietnam
10From Intense Trails to Intensive Care: Dicing with Death In a Mountain Biking Paradise
Owen Wright - Rip Curl Team profile
Growing up on NSW south coast Owen has been spoilt with perfect reef barrels and punchy beach breaks, Owen really made an impact on Hawaii's North Shore when he was only 14 surfing a day at 3rd reef Pipeline and scoring some huge heaving Pipe barrels. His style is smooth and tight in the pocket with a handbook of Aerial maneuvers Owen loves nothing more than floating above the lip, but is just as happy in big meaty barrels.
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Discover a selection of top forums devastation itself on the internet. Come to share your passion on forums devastation itself and meet other fans of devastation itself. Then, why don't you create your own forum of devastation itself ?
You wake up on a day where there is no peace, but instead, WAR.
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Eagle Collaborative Computing Services, Inc.
B-401043.3: Jan 28, 2011
Additional Materials:
- Full Report:
Ralph O. White
(202) 512-8278
(202) 512-4800
(202) 512-8278
Office of Public Affairs
(202) 512-4800
Eagle Collaborative Computing Services, Inc. (ECCS), of Stafford, Virginia, a small business, protests the award of a sole-source contract to Deque Systems, Inc. (Deque), of Reston, Virginia, by the Department of Housing and Urban Development (HUD) for Rehabilitation Act support and training services under the Small Business Administration's (SBA) section 8(a) program. ECCS argues that HUD did not comply with the sole-source procedures applicable to the section 8(a) program in the Federal Acquisition Regulation (FAR) when it awarded the contract to Deque.
We deny the protest.
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TiGi Bed Head After Party
599 reviews
83% would repurchase
Package Quality: 4.0
Price: $$$
Package Quality: 4.0
Price: $$$
INGREDIENTSWater , Dimethicone , Cyclopentasiloxane , Dimethiconol , Propylene Glycol , Polyacrylamide , Phenyl Trimethicone , C13-14 Isoparaffin , Fragrance , Amyl Cinnamal , Citral , Hydroxycitronellal , Benzyl Salicylate , Geraniol , Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde , Butylphenyl Methylpropional , Linalool , Citronellol , Hexyl Cinnamal , Limonene , PEG-8 Methicone , Ricinus Communis (Castor) Seed Oil , Laureth-7 , Sodium PCA , Dimethicone PEG-8 , Meadowfoamate , Cinnamidopropyltrimonium Chloride , Panthenol , Methylchloroisothiazolinone , Methylisothiazolinone , CI 77019 (Mica) , CI 77891 (Titanium Dioxide) , CI 77163 (Bismuth Oxychloride)
on 4/9/2013 1:51:00 AM
Age: 19-24
Skin: Very Oily, Fair, Warm
Hair: Brunette, Curly, Fine
Eyes: Green
I love this stuff! It smells good and the packaging is so freakin cute. My only thing is that I cant put it near my roots. It looks greasy. I mainly use this on the middle to ends of my hair and it keeps the frizz and fly aways under control. I have naturally curly hair. My hair is frizzy towards the ends. When my hair has dried, I apply this to the ends and it looks so smooth and flawless. You only need A TINY TINY bit. Less than a pea. It goes a very long way. I have had the same bottle for over a year and a half and I still have more than half of the bottle. I use it on a daily basis. TOTALLY recommend this magic!
on 4/9/2013 1:45:00 AM
Age: 19-24
Skin: Combination, Fair, Neutral
Hair: Silver, Wavy, Medium
Eyes: Brown
It leaves my hair feeling super smooth no fly aways, and it doesn't weigh my hair down!
Best of all my hair smells amazing all day long, like a sweet candy scent, i love it!
on 4/3/2013 3:01:00 PM
Age: 25-29
Skin: Normal, Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
Great product on my dry frizzy hair! Really calms it down without being greasy and it smells amazing!
on 3/31/2013 2:58:00 PM
Age: 19-24
Skin: Sensitive, Fair, Cool
Hair: Red, Wavy, Fine
Eyes: Blue
Ahhh, After Party, how I love you! Since Beyond The Zone d/c'ed Get'N'Creamed, I have had to repurchase this more expensive version of it, but it's such a necessity that I will gladly repurchase forever. My hair is colored & dehydrated, also pretty wavy and poofy all around. Oils weigh it down & looks greasy. This stuff is the tits, I use it on damp hair & blow dry or air dry. The result is soft, beautifully formed waves that lasts all day into the next. I love that there is no buildup or sticky feeling on my hair either. Of course, this can happen if you use too much, it's pretty concentrated so it sort of justifies the price as well (although I get this for $5 at TJ Maxx, score!) I also really love the scent of After Party, I have no idea why or what it smells like but it's amazing :)
on 3/30/2013 1:08:00 AM
Age: 18 & Under
Skin: Sensitive, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
I officially love this product. Funky packaging, excellent smell and best of all - it works so so well! I bought this from my hair salon after getting my hair cut (on sale: score!) and am so glad I did. Whenever my hair is feeling fly-away or frizzy, I work a very small amount through my hair and voila! Shiny, smooth, great-smelling hair. Note for my fellow fine-haired ladies, only use a tiny tiny bit of this, not even a full pump. Too much and your hair will end up greasy.
This is one of the best hair products I've ever used. Will definitely be buying again!
on 3/20/2013 12:39:00 PM
Age: 36-43
Skin: Combination, Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
GREAT smoothing product!..my hair is so dry and frizzy after washing, conditioning, and blow drying, even with leave in conditioner in it..Once I apply "After Party" it's incredibly smooth & silky, I love it..Gives really good shine too..NOTE: Do not use too much, or it will wear hair down, and give it a greasy feel. Pour just enough in the palm of your hand, rub it together nicely, then apply. Until I find something better, I will def repurchase! :)
on 1/11/2013 8:58:00 AM
Age: 30-35
Skin: Dry, Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Hazel
Fantastic product. I use this while my hair is still wet after shampoo and conditioning, Helps keep hair smooth once dried. I have super fluffy and frizzy hair after washing and this seems to help alot.
on 12/7/2012 3:49:00 PM
Age: 25-29
Skin: Oily, Fair-Medium, Neutral
Hair: Brown, Straight, Fine
Eyes: Green
I love this stuff been using it for years it smells amazing and does a great job of just softening your hair. don't use too much but just a about a dime size and distribute it evenly and your hair looks and smells awesome.
on 12/7/2012 12:33:00 PM
Age: 19-24
Skin: Combination, Dark, Warm
Hair: Black, Kinky, Coarse
Eyes: Brown
This styling cream smells awesome but it sucked. It did a better job on styling my hair extensions than my own actual hair. I applied it to my hair one day to actually see if the product would get rid of the frizz I consistently get and it left a white sticky film on my kinky hair. This product is better for people with straight hair. I was upset that I spent $22 on it but I do love the cute packaging.
on 11/20/2012 3:47:00 PM
Age: 18 & Under
Skin: Normal, Tan, Not Sure
Hair: Black, Other, Other
Eyes: Brown
i loooove this product so much. although my mom hasn't been buying it lately. this product makes hair soft and smell good, its great for if you flat iron your hair. it gets rid of damage. in my opinion this is a miracle product and i highly recommend that you buy this product if you are willing to try it. You'll love it!
Popular Styling Products


text:
With 1.7 million freelancers, we'll match you with the perfect talent.
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I am looking for someone who has a flair for creative writing. I would like the articles to be a great read and to include your personality, stories and opinions.
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It's important these articles have great headlines. I will provide you with some sample headlines to model.
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How Brazil's football legend turned every Corinthians' match into a political meeting for democracy.
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text:
Burt's Bees Beeswax Lip Balm
3603 reviews
66% would repurchase
Package Quality: 3.9
Price: $$
Package Quality: 3.9
Price: $$
Not tested on animals
Burt's Bees is a Cruelty-Free Subsidiary.
INGREDIENTSbeeswax, coconut oil, sunflower seed oil, peppermint oil, lanolin, tocopherol, rosemary leaf extract, soybean oil, canola oil.
on 8/13/2002 2:14:00 PM
Age: 19-24
Skin: Combination, Other, Not Sure
Hair: Brown, Other, Other
Eyes: Hazel
Super rich and tingly, I really like this balm in the winter, under a gloss or lipstick. It has a fun taste too, nothing gross like some other beeswaxy lip balms. It's great for the price, I just wish it had a gloss to it.
on 8/9/2002 1:08:00 PM
Age: 25-29
Skin: Dry, Fair, Not Sure
Hair: Red, Other, Other
Eyes: Blue
This is the lip balm that I use the most. I keep the tube in my makeup bag, and I have a tin at home. Does everything you want a lip balm to do and it's cheap! I even like this better than Karmex.
on 8/6/2002 9:11:00 PM
Age: 25-29
Skin: Dry, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
This lip balm is probably the best tasting I've ever tried, but unfortunately not the most moisturizing. The minty tingle feels great and the peppermint & coconut oil combination is yummy. But I found this drying and I kept having to reapply - not good!
on 8/6/2002 2:18:00 PM
Age: 18 & Under
Skin: Other, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
After using this for a couple days my lips started peeling. I know some like the tingle, but tingling just means drying for me.
on 8/2/2002 1:40:00 AM
Age: 25-29
Skin: Combination, Other, Not Sure
Hair: Blond, Other, Other
Eyes: Blue
A great lip balm, but not my fave. Great for the price tho!
on 7/30/2002 6:02:00 PM
Age: 19-24
Skin: Normal, Other, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
I adore this stuff!!! I always carry it with me-the tin it comes in is so practical... and cute. It feels great under lipstick.
on 7/28/2002 2:13:00 AM
Age: 30-35
Skin: Oily, Other, Not Sure
Hair: Black, Other, Other
Eyes: Black
This does moisturize and soften your lips. The stick form is easier to open and apply but I have the tin also. It gives your lips a slight tingle, which I don't think is bad. I would get this again.
on 7/26/2002 6:42:00 PM
Age: 19-24
Skin: Acne-prone, Medium, Not Sure
Hair: Black, Curly, Fine
Eyes: Hazel
Amazingly I think I'm the *only* person who likes the tin. The tingle is really neat, and my lips stay really soft! The only complaint I've heard from anyone around me is from my boyfriend, and he didn't understand why his lips were going numb until I told him (oops! heheh). One plus for the tin, I live in Nevada and tend to leave my chapstick in the truck, and it melts, I've tossed alot of chapstick tubes. The tin atleast holds the melted balm in place!
on 7/25/2002 2:11:00 AM
Age: 25-29
Skin: Other, Other, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
I love this stuff, it's a damned good lip balm. Has nice staying power, plus I love the peppermint and comfrey. The tingle makes me feel as though my lips are becoming delectabley plump! Good stuff.
on 7/23/2002 9:30:00 PM
Age: 19-24
Skin: Sensitive, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
I like the minty tasty. Lasts about as long as other lip balms, and I prefer something with sunscreen for the daytime. Also prefer the tube to the pot lip gloss--too hard to dig out when it gets about half full!
Popular Lip Treatments
1524 Reviews
306 Reviews
1219 Reviews
344 Reviews
178 Reviews
3603 Reviews


text:
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The field of statistics not only affects all areas of scientific activity, but also many other matters such as�public policy. It is branching rapidly into so many different subjects that a series of handbooks is the only way of comprehensively presenting the various aspects of statistical methodology, applications, and recent developments. The Handbook... more...
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HIPAA: Intent versus Actuality of the Law in Upholding the Privacy of Health Records Overview Introduction ���� How Did HIPAA Make the Policy Window? The Public Choice Theory Stakeholder Analysis ���� Stakeholder #1: Congress and Its Impact on HIPAA?s Formation ���� Stakeholder #2: Hospital and Provider Organization Staff (Physicians, Nurses, and... more...
Understanding Healthcare InformationFacet Publishing 2013; US$ 79.92
Analyses the domain of healthcare information, its organizational structures and history, and the nature of its resources and the drivers for change affecting them. This title looks at examples of healthcare information resources from the perspective of different user groups, including healthcare professionals and consumers. more...
Bioinformatics Software EngineeringWiley 2005; US$ 100.95
Paul Weston has nearly two decades' experience in application development, gained in environments as diverse as entrepreneurial start-ups and monolithic bureaucracies. From MVS to XP, from COBOL to Java, and from Structured Programming to Struts - he has wrestled with them all.He began developing bioinformatics applications in the mid-1990s... more...
Bioinformatics Biocomputing and PerlWiley 2005; US$ 125.00
Michael Moorhouse works as a Bioinformatics Researcher for Erasmus MC in Rotterdam, The Netherlands. He holds a B.Sc. from UMIST and an M.Sc. from The University of Manchester. Michael recently completed a Ph.D. from The University of Birmingham in the UK. He has been involved in numerous bioinformatics courses throughout the UK and Netherlands.... more...
Essential BioinformaticsCambridge University Press 2006; US$ 68.00
Clear, concise introduction to bioinformatics, written specifically to be accessible to a life science audience. more...


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Baby in Womb Claps Along With Parents During Ultrasound
This baby has some heart...and some serious soul.
This baby has some heart...and some serious soul.
"You've already got two!"
This baby is getting a roar of approval from the Internet.
Charlie is a dog that knows when he's done wrong. And, boy, does he feel bad.
When you have a dog and a baby, you win the internet.
Babies can have trouble staying focused.
What's even cuter than a baby balancing perfecting on a moving Roomba? A baby riding a Roomba to the soundtrack of 'Ridin'' by Chamillionaire.
It doesn't matter how old you are—dogs are funny.
Taking care of a baby may take a lot of hard work, but fighting one is actually pretty easy.
My son Craig, who is now 24, was born about six weeks early. He was in the neonatal unit at Eastern Maine Medical Center for three-four weeks and received incredible care.
I saw this video and those first-year memories came flooding back to me -- from the first time that my wife held him, with all the tubes, to bringing him home on monitors and frantically running into his room to check on him when the monitor started beeping
It all started with the 'Dogshaming' meme, where owners took to the Web to expose their misbehaving pooches. Then there was bunny shaming, which taught us that even those little guys can get into trouble. But that ain't got nothin' on the latest version -- baby shaming brings this trend to an entirely new level of adorable.
The royal baby isn't the only newborn who was on display this month.


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47 years of experience
Accepting new patients
47 years of experience
Accepting new patients
UPMC Latterman Family Health Center
3000 Stonewood Dr
Ste 200
Wexford, PA 15090 Phone number & directions
3000 Stonewood Dr
Ste 200
Wexford, PA 15090 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Lawrence Collins:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
Patient comments (1)
The overall average patient rating of Dr. Lawrence Collins is Good.
Specialties & Research
Dr. Lawrence Collins, MD is board certified in Urology.
- He has special expertise in 2 areas:
- General Urology
- Overactive Urinary Bladder
Education & Awards
Dr. Collins graduated from Georgetown University, Washington.
Dr. Collins has 9 hospital affiliations:
- Allegheny General Hospital
- UPMC Horizon
Home > Find an Urologist > PA > Wexford Urologists > Dr. Lawrence Collins, MD
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- Additional Information
- Dr. Lawrence Albert Collins MD is a male Urologist, has 47 years of experience and practices in Urology.
- Where does Dr. Lawrence A. Collins practice?
- Dr. Lawrence Collins has 8 office locations.
Dr. Lawrence Collins practices Urology near Wexford, PA.
Additional practice locations include: Pittsburgh, PA.
See Wexford Urologists.


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Barack Obama
Sequestration 2013: District of Columbia impact due to budget cutsComment
On Sunday, the White House released state-by-state reports on the potential impact that sequestration would have on all 50 states and the District of Columbia. Here is the report regarding D.C.
Sequestration 2013: Maryland impact due to budget cutsComment
On Sunday, the White House released state-by-state reports on the potential impact that sequestration would have on all 50 states and the District of Columbia. Here's the report on Maryland.
Sequestration 2013: Virginia impact due to budget cutsComment
On Sunday, the White House released state-by-state reports on the potential impact that sequestration would have on all 50 states and the District of Columbia. Here's the one regarding Virginia.
White House details sequester impact if inaction continuesComment
The White House has detailed the potential fallout in each state from budget cuts set to take effect at week's end, while congressional Republicans and Democrats keep up the sniping over who's to blame.
GOP governors shift gears, soften rhetoric toward ObamaComment
The shift is most pronounced on health care, where seven states led by Republican governors are pushing to expand their Medicaid program under Obama's health care law. Such a move once was considered anathema in the party.
Gen. John Allen retiring from United States militaryComment
President Obama says he has accepted Gen. John Allen 's request to retire from military.
Tiger Woods joins vacationing Obama for round of golfComment
The foursome also included Houston Astros owner Jim Crane, who also owns the Floridian, a secluded and exclusive yacht and golf club, and outgoing U.S. Trade Representative Ron Kirk, a former mayor of Dallas. The White House prohibited any media coverage.
President Obama urges action on gun violence, preschool, jobs, wagesComment
In remarks Friday at Hyde Park Academy in his hometown of Chicago, Obama says by reducing gun violence, expanding preschool access, raising the minimum wage and improving job training, the U.S. can ensure every child has a chance to succeed.
Obama re-nominates three officials previously blocked by GOPComment
President Obama has re-nominated two members of the NLRB and the director of the CFPB. All three had been recess appointments last year after Republicans prevented the Senate from taking up-or-down confirmation votes.
Marco Rubio's water break: Rubio takes mid-speech swig (video)Comment
Florida Sen. Marco Rubio's mid-speech swig from a small Poland Spring water bottle during his GOP response generated instant reaction in social media circles and on cable television, even as Republicans offered fresh appeals on the economy and promises to rein in federal spending.
Minimum wage 2013: Barack Obama calls for $9 minimum wage (Video)Comment
President Obama has called for an increase in the national minimum wage from $7.25 to $9 an hour. It's a controversial proposal as small business owners worry about paying more to employees, while those working for minimum wage would welcome any bump in pay.
Obama travels to N.C. to rally support for jobs planComment
President Obama is kicking off three days of travel to rally support for the job-creation in Asheville, N.C., with a visit to Linamar Corp., a supplier of engine and transmission components.
State of the Union 2013: Economy, gun control on Obama's radarComment
In his first State of the Union address since winning re-election, Obama conceded economic revival is an "unfinished task," but he claimed clear progress and said he was seeking to build on it as he embarks on four more years in office.
State of the Union 2013: Streaming video, Twitter talk, and moreComment
From the hot topics President Obama will touch on, to where you can watch the address live to how to keep up with the very latest Twitter chatter, everything you need to know about the State of the Union is right here.
Afghanistan troop withdrawawl will bring 34,000 troops homeComment
President Barack Obama will announce during the State of the Union that 34,000 U.S. troops will be home from Afghanistan within a year.
State of the Union 2013: Twitter talk surrounds Obama's addressComment
The economy is set to be a major topic of conversation during Tuesday's address, but guns and gun control also promise to be a major talking point.
Obama 2013 State of the Union: Obama to push for tax increasesComment
President Obama will press a politically-divided Congress to approve more tax increases and fewer spending cuts during a State of the Union address focused on stabilizing the middle class and repairing the still-wobbly economy.
Obama's Commandments: How the president is wielding executive power in 2nd termComment
This is what "Forward" looks like. Fast forward, even. President Barack Obama's campaign slogan is springing to life in a surge of executive directives and agency rule-making that touch many of the affairs of government.
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Oesophageal atresia and tracheo-oesophageal fistula
- Departments of Paediatric Surgery and Paediatric Respiratory Medicine, Royal Liverpool Children's Hospital (Alder Hey), and Department of Child Health, University of Liverpool, UK
- Correspondence to:
Institute of Child Health, Royal Liverpool Children's Hospital (Alder Hey), Eaton Road, Liverpool L12 2AP, UK; paul.losty{at}liv.ac.uk
- Accepted 15 November 2005
Oesophageal atresia-tracheo-oesophageal fistula has featured in paediatric surgery since its beginnings. The first successful primary repair was in 1941. With overall survival now exceeding 90% in dedicated centres, the emphasis has changed to reducing morbidity and achieving improvements in the quality of life. An overview of current and emerging strategies in managing patients with this condition is presented. Advances in developmental biology and molecular genetics reflecting improved understanding of the pathogenesis are highlighted.
Competing interests: none declared


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In memory of my sweet husband Ken Tarczewski. Worked and loved his job at the center. Was taken away from us way to soon.
In memory of my friend and colleague, Ken Tarczewski, who loved the Frazer community so much and helped make it an amazing place to be.
In Honor of Ken Tarczewski for his commitment toward The Frazer Center
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Gunmetal Black Ep 01
episode 14.24 / 5.00 4,752 Views
Lucina's First Day
A look at the first day of Lucina in Super Smash4.24 / 5.00 15,215 Views
BATMAN v SUPERMAN final showdown
SPOILERS!!4.17 / 5.00 13,978 Views
I really like the animation. Good stuff
nooooooo tricky died
Hmmm nice animation, can remind me of the Last Chapter/Episode Abbrogation...
Tricky lies down, Auditor uses Jebus, Hank has a sliced head and he gets revived.
the story was madness accelerent hank was not suppost to die in the end and jebus wasnt suppost to kill anyone hank was suppost to kill the clown wanna know how i know that because i beat the madness game yeah check my profile you will see for yourself
wow hanks face has been slashed to HALF!!!!


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Original recipe yields 8 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Ready In
Wonderful! I too changed the sugar to Agave (equal amount). I used cornstarch to thicken the liquid at the end to make more of a sauce as it was very runny. I might try rice next time instead...
I made this the other night and thought it was good, but agreed with another reviewer that found the vinegar flavor a little strong. I added tofu and omitted the edamame and it was tasty and fi...
I found this recipe to be a bit too vinegary. In the future I will cut down on the vinegar. Also I served it over rice, but the rice over absorbed the vinegar taste.


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I always used to wonder when watching gay porn in the 1990s how the deuce the models managed to get their pants over their chunky butch boots without removing them.
Now of course every straight male from South London learns how to do this before they can legally drink in pubs — as 'Forbidden Nights', an act auditioning on Britain's Got More Talent recently demonstrated.
Note how the camp judge (David Walliams) is contractually bound to be 'gay' — regardless of the fact he's straight. And twice the size of the rather lovely pocket-sized stripper he hugs (no doubt he had to have his suit dry-cleaned of orange body make-up).
Note also how 'sexualised images' of the male body — and extreme close-ups of cotton-lycra mix bulges — are now an entirely acceptable, and enthusiastically applauded, part of British prime-time family entertainment.
Something the American Phalliban successfully sabotaged in the BBC's recent Wolf's Hall — spoilsport American TV execs insisted the Tudor codpieces be toned down.
Hooray for Hollywood however — who gave 'Sexiest Man Alive' Chris Hemsworth one the size of, well, the hammer of a Norse god of thunder, in the just-released 'red band' trailer for the forthcoming remake of National Lampoon's (R-rated) Vacation.
That's probably way more phallus than you'll get in Magic Mike XXL.
Tip: Hans Versluys


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Fans of Suzanne Collins' dystopian teen drama "The Hunger Games" have long predicted that the series' big-screen adaptation would emerge victorious from its box-office battle. And now, it seems, preliminary estimates support the stan speculation.
Deadline reports that the early tracking figures for the March 23 release are "numbers every film studio can only dream about," with 23 percent of respondents selecting the film as "First Choice" and 54 percent indicating "Definite Interest." In fact, one estimate Deadline editor Nikki Finke received predicted the film could open to more than $70 million — narrowly besting the "Twilight" opening-weekend gross of $69.6 million. All good news for fans fretting over the series' fate … but what do these numbers really mean?
Tracking, in essence, measures the results of a studio's marketing campaign and is by no means an exact science.
"The real use of tracking is to measure the effectiveness of the marketing weeks out from release, so you can make adjustments while there's still time," Vinny Bruzzese, president of the worldwide motion-picture tracking firm OTX, told TheWrap as part of an interesting piece examining the practice. "By the time the official prediction comes out on the day of the release, it's fairly useless."
Clearly, Lionsgate's clever campaigns (including Capitol Couture, puzzle scavenger hunts and advanced screening giveaways) have resonated with fans and non-fans alike, gaining plenty of exposure for the fledgling franchise. However, we must remember that tracking is not necessarily meant to prognosticate box-office returns (TheWrap's story calls such predictions nothing more than "parlor tricks").
For argument's sake, however, let's say that "The Hunger Games" does indeed meet its $70 million expectations. Lionsgate CEO Jon Feltheimer told Bloomberg that the debut installment would need to earn $100 million in overall domestic sales to justify a sequel. With a potential $70 million opening weekend, the film would need to gross only $30 million more to reach that benchmark. And unless attendance drops off as steeply as the Arena's cliff, it will prevail, all but guaranteeing "Catching Fire" will, well, catch fire.
Are you cautiously optimistic about the "Hunger Games" box-office outlook? Sound off in the comments below and tweet me @amymwilk with your thoughts and suggestions for future columns!
Check out everything we've got on "The Hunger Games."
For young Hollywood news, fashion and "Twilight" updates around the clock, visit HollywoodCrush.MTV.com.


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Music from this release
- Christopher Owens: "Lysandre's Theme" / "Here We Go" (via SoundCloud)
You can tell a lot about how Christopher Owens is feeling by looking at his hair. Back in 2009, when Girls first emerged, Owens' long, greasy locks seemed to serve a strategic purpose: They formed a thick veil behind which he could seek sanctuary, as he exposed the pain and longing that fuelled attention-seizing early singles like "Lust for Life" and "Hellhole Ratrace". The mesmerizing qualities of hair certainly weren't lost on Owens, who gave the name "Curls" to a blissful instrumental on Girls' debut, Album, and who used the lead-off track on 2011's follow-up, Father, Son, Holy Ghost, to reassert his "dirty hair" as an outsider status symbol. But Owens treated the more nakedly confessional songs of Father, Son, Holy Ghost as an opportunity to clean up his visage; the tours for that album saw him more comfortably settle into the role of bandleader, facing the crowds and late-night TV-show cameras straight-on through a neatly parted, tidily trimmed coiffure.
So it's rather curious that 0n the cover of his first release since Girls' surprising dissolution, Owens appears to be both ready for his close-up yet eager to use his mangy mane as a barrier. It's but the first of many contradictions that define the equally fascinating and frustrating Lysandre, a narrative concept album that runs a mere 29 minutes and is both more musically ornate yet somehow also slighter than anything Girls attempted, a deeply personal work whose arch presentation serves to keep you at an emotional distance.
When an artist opts to release a record under their own name, there's often the implication that songs will be more autobiographical and introspective. But where Girls provided Owens with a vehicle to translate his uniquely fucked-up life experiences into affirming, universal anthems, Lysandre presents very specific details of a particular moment in Owens' life-- complete with names, locations, and copious references to his singer-songwriter vocation-- in a more contrived setting. It's as if he were staging a dramatized meta-musical about his life. On the opening address "Here We Go", Owens sings, "If your heart is broken/ You will find fellowship with me" as if introducing himself to the audience as a character in his own play, the song's serene, pastoral-folk finger-picking and titular command signaling the dimming of the house lights.
Owens recently admitted to Pitchfork that Lysandre is an album that he just had to get out of his system, presumably to bring proper closure to the romantic relationship that blossoms and flames out (in inverse relation to Owens' ascendant musical career) over the course of the record. Though divided into 11 tracks, Lysandre functions as a single, continuous piece, with a recurring instrumental motif ("Lysandre's Theme") serving as a thread and reinforcing that sense of feeling haunted by a memory. But if the story of Lysandre is so significant to Owens that it demanded its own song cycle, his musical treatments don't always do the material justice.
On Girls' albums, Owens undercut the sense of despair with moments of levity, but Lysandre overemphasizes the latter quality to the point of undermining the sensitive subject matter. The chirpy flute lines that cut through "Here We Go" and the buoyant title track cross the line from classy embellishment to garish distraction, and the disarming portraits of poverty, desperation, and violence that run through "New York City" are neutered by an oddly upbeat execution that confuses the Velvet Underground's idea of rock 'n' roll with that of Huey Lewis, thanks to an interminably goofy sax solo that oversells the optimism of starting life anew in the Big Apple. But even those transgressions don't quite prepare you for "Riviera Rock", a transitional mid-album ersatz-Santana jam that apparently signifies some unexplained tropical-getaway plot turn, but comes off like a tiki-lounge act's introducing-the-band segment.
Owens is keenly aware of the risks he's taking with Lysandre: Though the insecurities expressed on the winsome "Love Is in the Ear of the Listener"-- "What if everybody just thinks I'm a phony/ What if nobody ever gets it?"-- may stem from his early-career stage fright, they're just as trenchant now that he's derailed a much-loved and increasingly popular band to go solo. But the songwriting is rarely a problem on Lysandre: The dolorous acoustic ballads "A Broken Heart" and "Everywhere You Knew" show that Owens' command of understated devastation remains unparalleled, using simple, seemingly mundane imagery to set unspeakably intimate scenes of awkward first kisses and airport farewells. And the excellent closer "Part of Me (Lysandre's Epilogue)" brings this occasionally gaudy album to a refreshingly grounded conclusion, forsaking the baroque flourishes in favour of a Harvest-worthy harmonica refrain and gently rollicking country rhythm. "You were a part of me/ That part of me is gone," Owens sings with a combination of sadness and relief, bidding farewell to his girl, or Girls, or maybe just to that part of him that was itching to make a prog-folk concept album overstuffed with sax and flutes. At the very least, Owens emerges from the other side of Lysandre sounding liberated, and ready to brush that hair out of his eyes once again.
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Printable Area
Photo by I'mPat
Photo by I'mPat
"This is very easy to make. Just spread on mustard, sprinkle with bread crumbs and bake! The directions are for the toaster oven, but this can easily be done in a regular oven."
Serving Size: 1 (226 g)
Servings Per Recipe: 1


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Wind River Brings Own Android to MarketDec 08, 2009
Embedded specialist Wind River strives to win mobile network users with hardware compliance and its own Android branding.more »
FreeNAS: BSD Line and Linux ForkDec 08, 2009
The FreeNAS project had discussed whether the free storage systems should use BSD or Linux in the future. The result is that both variants will now be available.more »
Kernel Plans for Ubuntu 10.04Dec 07, 2009
On Thursday, the first alpha version of Ubuntu 10.04 LTS is to be made available. The official release will be out in April 2010. Ubuntu 10.04 LTS should feature significantly more stability, being based on the just released Kernel 2.6.32 as a precedent to the Long Term version.more »
Q4 Novell: Revenue Down, Loss UpDec 07, 2009
In its fourth fiscal quarter of 2009, Novell achieved a net revenue of $216 million, a figure down on the $245 million for the same period last year.more »
Groupware VMs for EvaluationDec 04, 2009
The Mountain View CA startup WireLoad is offering current versions of its group suites Scalix and Zimbra as virtual appliances.more »
SugarCRM 5.5: New Views and InterfaceDec 04, 2009
The Californian company SugarCRM has released its open source based CRM software in version 5.5.more »
OpenSUSE Says Farewell to SaX2Dec 03, 2009
When the graphical interface setup under openSUSE didn't work just right, one could always run SaX2 to correct it. Now Novell wants to retire the tool.more »
CeBIT 2010: Call for Papers for Open Source ForumDec 02, 2009
Linux New Media AG is organizing an integrated presentation series for the Open Source Forum at the CeBIT 2010 running March 2 through 6 in Hanover, Germany. Users from organizations and agencies as well as developers from the open source community are invited to apply for a free presentation slot up until January 7, 2010.more »
Issue 177/2015
Buy this issue as a PDF
NoScript Flaw
Mozilla's script blocker add-on could be putting malware sites on the whitelist.
RIP SSLv3
The Internet community officially banishes the notoriously unsafe Secure Sockets Layer protocol.
Mate 1.1 Arrives
Popular desktop environment continues the Gnome 2 legacy – with new support for the Gnome 3 toolkit.
US Government Requires HTTPS
The Obama White House has issued a memorandum telling all US government agencies they must use HTTPS for all websites and web communication.
Mozilla Signs Firefox Add-Ons
New program will dial up security for the Firefox browser.
Fedora 22 Arrives
Red Hat's community distro embraces the cloud.
Code.org and College Board Team Reach Out for Talented High School Coders
New partnership will bring more and better CS training to US schools
A Peek Inside TeslaCrypt Ransomware
Criminals offer online help over Tor network
Mumblehard Still Spams
Sophisticated malware is still present on Joomla and WordPress sites around the world.
Launchpad Gets Git
Future versions of Ubuntu's code service will support the popular Git version control system used with Linux and other open source projects.


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All clinically-approved and many novel gadolinium (Gd)-based contrast agents used to enhance signal intensity in magnetic resonance imaging (MRI) are optically-silent. To verify MRI results, a "gold standard" that can map and quantify Gd down to the parts per million (ppm) levels is required. Nuclear microscopy is a relatively new technique that has this capability, and is composed of a combination of the three ion beam techniques: scanning transmission ion microscopy (STIM), Rutherford back scattering spectrometry (RBS) and particle induced X-ray emission (PIXE) used in conjunction with a high energy proton microprobe. In this proof-of-concept study, we show that in diseased aortic vessel walls obtained at 2 hours and 4 hours after intravenous injection of the myeloperoxidase-senstitive MRI agent, bis-5-hydroxytryptamide-diethylenetriamine-pentaacetate gadolinium, there was a time-dependant Gd clearance (2-hr = 18.86 ppm, 4-hr = 8.65 ppm). As expected, the control animal, injected with the clinically-approved conventional agent diethylenetriamine-pentaacetate gadolinium and sacrificed 1 week after injection, revealed no significant residual Gd in the tissue. Similar to known in vivo Gd pharmacokinetics, we found that Gd concentration dropped by a factor of two in vessel wall tissue in 1.64 hrs. Further high-resolution studies revealed that Gd was relatively uniformly distributed, consistent with random agent diffusion. We conclude that nuclear microscopy is potentially very useful for validation studies involving Gd-based MR contrast agents.
Magnetic resonance imaging (MRI) is a powerful non-invasive, non-ionizing imaging modality that is primarily used for medical imaging but also plays an important role in basic science research. It can provide anatomical, functional, metabolic, cellular and molecular information of tissues in vivo with high resolutions in three dimensions, routinely down to 1 mm at clinical field strengths and even down to about 50 μm in research settings (Strijkers et al., 2007). Soft tissue contrast in MR images is generated by highlighting differences in the longitudinal (T1) and transverse (T2) relaxation times of protons in different tissues. Tissue differences can be made greater by shortening T1 and/or T2; shortening of T1 is often preferred as this leads to gain of signal versus loss of signal via shortening of T2.
In order to shorten either T1 or T2, contrast agents (CAs), which are diagnostic pharmaceutical compounds containing paramagnetic or superparamagnetic metal ions (Bellin, 2006), are administered. The influence of a paramagnetic ion on the relaxation time depends directly upon the number of unpaired electrons generating the electronic spin that interferes with the nuclear spin of hydrogen (Idee et al., 2006). Gd (III) ions, which are paramagnetic, contain 7 unpaired electrons and yield very strong T1 relaxation properties (Brasch, 1992); making Gd compounds the most widely used CAs in MRI. For Gd to be safely administered in vivo, a chelator such as diethylene triamine pentaacetic acid (DTPA) that prevents Gd toxicity, must be used.
In order to verify the in vivo imaging results obtained using Gd-chelates in MRI, a complementary technique is required to map Gd spatially and simultaneously quantify Gd down to the parts per million level and normalized to the density of the tissue. No technique has so far exhibited this capability. Such a technique would also allow one to look at the tissue distribution of the agent in relation to tissue composition and explore whether the agent may highlight specific disease components. The aim of this study was to examine the capability of nuclear microscopy to map and quantify Gd in tissue sections.
There were three main objectives of this study. First, to determine whether or not nuclear microscopy is sufficiently sensitive to detect Gd in atherosclerotic aortic sections from cholesterol-fed rabbits after intravenous injection of bis-5-hydroxytryptamide-diethylenetriamine-pentaacetate gadolinium (bis-5HT-DTPA(Gd)). Bis-5HT-DTPA(Gd) is an enzyme-activatable agent targeting myeloperoxidase (MPO) (Querol et al., 2005, Querol et al., 2006 and Chen et al., 2006). MPO is an abundant heme enzyme released by activated leukocytes and catalyzes the formation of a number of reactive species that, among many harmful biological effects, can modify low-density lipoprotein (LDL) to a form that converts macrophages into lipid-laden or 'foam' cells, the hallmark of atherosclerotic lesions (Wada et al., 2000, Carr et al., 2000). Validation of this novel MPO-sensing imaging agent is an extremely important step toward the ultimate goal of producing MR images that reflect atherosclerotic plaque vulnerability. For control, we sacrificed a cholesterol-fed rabbit one week after injection of the clinical standard agent diethylenetriamine-pentaacetate gadolinium (DTPA(Gd)). This agent is the parent compound on which bis-5HT-DTPA(Gd) is based though it possesses no molecular specificity.
Second, we explored the use of this technique to detect changes in Gd levels over time by examining aortic sections obtained at 2 hours and 4 hours after bis-5-HT-DTPA(Gd) injection. Thirdly, high-resolution studies were also performed to evaluate if this particular agent had any preferential distribution within the aorta.
Aorta samples were obtained from three male New Zealand white rabbits fed on a low-level cholesterol diet. Two of the rabbits were fed on a diet of 0.25% w/w cholesterol diet for 8 months followed by 0.125% w/w cholesterol diet for another 10 months, while the 3rd rabbit was fed the 0.25% diet for 17 months followed by the 0.125% diet for an additional year. This model was chosen because rabbits fed cholesterol-containing diet (0.15−0.3% w/w) over extended periods of time develop aortic lesions that resemble late stage human atherosclerotic lesions (Daley et al., 1994a, Daley et al., 1994b, Ronald et al., 2007). The first test rabbit (18 months on diet) received 0.2 mmol/kg of bis-5HT-DTPA(Gd) injection 2-hrs prior to sacrifice, while the second test rabbit (29 months on diet) received the injection 4-hrs prior to sacrifice. A third rabbit (18 months on diet) received DTPA(Gd) injection one week prior to the sacrifice. Previous nuclear microscopy experiments carried out at our centre over the last decade have shown that once atherosclerosis sets in, the elemental distribution exhibits similar trends regardless of age or the duration of cholesterol feeding (Watt et. al. 2006). These trends indicate that rabbits that have been fed a cholesterol diet for more than 1.5 years show significant lesion development (Ronald et al., 2007). Since the focus of the study was on assessing the capability of nuclear microscopy to measure Gd, the variations in age and duration of administration of the high cholesterol diet is unlikely to affect our ability to detect Gd. Animals were cared for in accordance with guidelines of the Canadian Council on Animal Care.
At sacrifice, each animal was sedated via an intramuscular injection of stock anesthetic (ketamine (23.4 mg/kg), xylazine (1.3 mg/kg) and glycopyrolate (0.02 mg/kg). Sedated animals were sacrificed with an intravenous injection of ketamine (200 mg) and transcardially-perfused under pressure with ~1.5 L of heparinized (1 IU/ml) Hanks' balanced salt solution. Fresh-frozen aortic tissue blocks (5 mm thick) were collected every 3 mm superiorly, starting 1 cm above the celiac bifurcation. 3 blocks were collected from the 2-hour post rabbit and 4 blocks from the 4-hour post rabbit. Cryostat sectioning was performed and 2 contiguous 10 micron sections from each block were collected on pioloform wrapped aluminium holders.
Nuclear microscopy, using a combination of the three techniques--PIXE (particle induced X-ray emission), RBS (Rutherford backscattering spectroscopy) and STIM (scanning transmission ion microscopy), has the unique capability to map multiple elements above sodium in the periodic table and simultaneously quantify them down to the parts per million levels. Nuclear microscopy is ideally suited for measuring the trace elemental distributions in atherosclerotic tissue (Watt et. al. 2006, Roijers et. al. 2008).
The nuclear microscopy experiments were carried out at the Centre for Ion Beam Applications (CIBA) at the National University of Singapore (Watt et al., 2003). A 2.1 MeV proton beam was focused to a spot size of 1 μm and scanned across the region of interest. Data from the three techniques of STIM, PIXE, and RBS were simultaneously collected. STIM provides structural maps based on the energy lost by the protons as they pass through the relatively thin organic samples with thicknesses of 30 μm or less. This enables structural identification without fixing or staining. The trace elemental mapping was carried out by PIXE (Johansson 1995), a non-destructive technique, which simultaneously detects multiple elements with high quantitative accuracy and with a sensitivity of down to 1 ppm in biological material such as tissue sections and cells. The quantification in PIXE was validated by the use of a standard target of known elemental composition with certified homogeneity, manufactured by the National Institute of Standards and Technology (NIST, USA). RBS was used to measure the concentration of matrix constituents of the sample. Large scans of 4 mm scan size were carried out to observe the overall distribution of the elements. In order to examine the spatial distribution of Gd, higher resolution scans were carried out (680 μm scan size) later. The data analysis was carried out using a combination of computer codes; SIMNRA(Mayer 1997), Dan32, Gupix (Maxwell 1989) and Mathematica.
Using the three techniques mentioned above, large area scans of 4 mm scan size were carried out to examine the overall distribution of the elements across the artery and lesion.
In order to map gadolinium, the tissue was scanned by a 2.1 MeV proton beam. The collision of the beam with the atomic electrons in the sample and subsequent de-excitation leads to the emission of X-rays, which are unique to the parent atom. X-rays of different elements were detected simultaneously using a lithium-drifted silicon X-ray detector placed at 90° to the beam axis and fitted with a filter designed for detection of elements above sodium in the periodic table. Gadolinium was measured based on the emission of Gd Lα X-rays at energy of 6.05 keV. The well resolved Mathematica fits of the PIXE spectrum with the Gd peak adjacent to the Fe Kα peak of one sample from each of the groups under study are shown in figure 1. Our nuclear microscopy studies are the first to map gadolinium in unstained tissue.
To further describe the distribution of gadolinium throughout the diseased aortic wall, high-resolution studies were carried out. Areas comprising the atherosclerotic lesion and the adjacent artery walls were chosen for high resolution nuclear microscopy scans. We obtained the tissue samples at fixed locations along the aorta. When we compared the Gd concentrations no correspondence between the animals at the fixed locations was observed. In addition, no trend was identified within the same rabbit based on location along the aorta. The structural STIM maps and the gadolinium maps of the areas chosen for high-resolution studies are shown in figure 2. The high-resolution studies showed that the gadolinium was relatively uniformly distributed across the tissue, without substantial preferential distribution, at both time points. Given that the agent has been demonstrated to be highly specific for MPO ((Nahrendorf et al., 2008, Breckwoldt et al., 2008), we had hoped that we could detect a differential distribution pattern. However, as the tissue samples were collected several hours after bis-5HT-DTPA(Gd) administration (2 and 4 hours post injection) it is not completely unexpected that Gd would be homogeneously distributed throughout the plaque as the agent is a small molecule and can diffuse easily throughout the tissues. Furthermore, this agent does not bind to MPO, but is activated by MPO to become oligomers with slower rotational dynamics to result in higher MRI signal intensity. Future studies will look at collecting tissue early after administration of the agent (within the first 30 minutes) where preferential distribution within the fibrous cap of the plaques has been described (Wasserman et al, 2005). Alternatively, an agent known to distribute inhomogenously within atherosclerotic tissue such as Gadofluorine-M (Meding et al., 2007) could be used.
To calculate the elemental concentrations, the data obtained from PIXE and RBS were analyzed using a combination of various computer codes; SIMNRA, Dan 32, Gupix and Mathematica. To eliminate the possibility of errors in the counts of the Gd Lα peak (6.056 keV) due to the proximity of the large number of counts of the adjacent Fe kα peak (6.398 keV), the Gd peak from each PIXE spectra was manually fitted using Mathematica and the area counts (minus the background) and percentage errors obtained. These results, in conjuction with Gupix, helped to determine the concentration at the parts per million level. The Gd and the Fe peaks are seen sufficiently resolved in the Mathematica fits of the PIXE spectrum (Figure1).
Our studies showed that the gadolinium concentration was below 20 ppm in all the sections examined. This cannot be compared to any previously known figures for verification as Gd has never been quantified in this manner before. Figure 3 compares the overall distribution and concentration of Gd in the 4-hr group to that in the 2-hr group of the sections at fixed locations along the aorta. The average concentrations of Gd are shown in the graph (Figure. 4). The Gd concentration is consistently higher for the 2-hr group compared to the 4-hr group, with the averages showing a significant difference (p < 0.05) The 4-hr group also showed a greater variation in concentration (standard deviation = 3.5 ppm) compared to the 2-hr group (standard deviation = 0.8 ppm).
The clearance of Gd in humans depends on various factors including the compound used (Bremerich et al., 2001), the tissue type and the age of the patients (Baker, 2004). While the number of animals used in this proof-of-principle study is small, it would be useful to compute a clearance rate as an example of the type of analysis that can be obtained from the technique we developed in this study. For bis-5HT-DTPA(Gd) in diseased aortic wall from rabbits, the clearance time for Gd concentration to drop by a factor of 2 in this study was 1.64 hours. This was obtained by fitting the data points corresponding to the measured concentration at 2 and 4 hours to an exponential decay model. While the small samples size used in this study precludes definitive conclusions to be made from this calculation, this value is nonetheless similar to the biological elimination half-life of 1.5 hrs calculated for human patients (Bellin, 2006).
The tissues obtained at one week after DTPA(Gd) injection was used as a control as at this time point the agent would be cleared from the tissues. Indeed, the Gd concentration we obtained was dramatically lower than at 2 and 4 hours (2-hr = 18.86 ppm, 4-hr = 8.65 ppm). The Gd concentrations for the 1 week sample (2.7 ppm) is at the detection threshold of the PIXE technique, estimated to be about 2−3 ppm for Gd and therefore not significant. A comparison of the Mathematica fits of the 2-hr, 4-hr and 1-week animals illustrates this (Figure 1).
Nuclear microscopy has, for the first time, simultaneously mapped and quantified Gd in tissue sections obtained after intravenous administration of a Gd-based MR contrast agent. The techniques described here can be used to image Gd based compounds and we believe will be particularly applicable for assessing optically-silent conventional and novel MRI agents. Furthermore, the quantitative nature of our technique was sufficiently sensitive to changes in Gd concentration over time. Comparing the Gd concentration in the arteries of rabbits sacrificed 2 hours and 4 hours after intravenous injection of gadolinium agents, it was found that the concentration of Gd was consistently higher in the 2-hour animal compared to the 4-hour animal. The one-week control did not show any significant residual gadolinium in the tissue.
This study illustrates the possibility of using nuclear microscopy to better understand the mechanism of Gd-based MRI agents and to map and quantify the biodistribution of these agents at very high spatial resolution. Our findings suggest that nuclear microscopy could be developed as a quantitative standard to complement MRI, in animal or human studies where tissues may be removed after imaging. In the future, by comparing the nuclear microscopy maps to adjacent histological sections we can further understand the biodistribution of Gd-chelates that localise to specific structures which may be revelant to disease characterization and/or progression.
We thank Kem Rogers, Amanda Hamilton, Elisenda Rodriguez, Andre Belisle, Gloria Chiang, Allison Lee, and Fred Reynolds for experimental assistance. We also acknowledge early contributions by Alexei Bogdanov and Manel Querol in developing bis-5HT-DTPA(Gd). BKR holds the Barnett-Ivey Heart and Stroke Foundation of Ontario Research Chair. JAR holds the Great-West Life doctoral research award from the Heart and Stroke Foundation of Canada. The work was supported in part by the National Institute of Health grants KO8HL081170 (JWC) and RO1-HL078641 (RW, BKR).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Labels: Contemplative photography, endings, evening, Ireland
Some day we might figure out how it happened that Ireland, a once conservative, Catholic society where abortion is still illegal, mobilised and voted to enshrine equal marriage in our constitution? Where our young people came home to vote from all over the world, where Grandparents spoke in favour of something which for their generation had been unheard of. Where we all wept one minute and grinned our ears off the next and couldn't believe in the goodness of some people or then in the downright meanness of others.
What swung it? How did the likes of us, end up here, marching in this Pride Parade with 50-60,000 others? At that first meeting in the Mother of Pearl Cafe in Tramore, I wondered how we could possibly pull this off and how devastating it would be if the country voted No?
8 weeks later.....it seemed as if the world had changed.....
For me it was always about creating safety, belonging, love. We were asking for something so positive, a YES. We were asking Ireland to grow up, to embrace diversity, and citizenship. And in keeping with my own work of 30 years in Framework it was also about progressing equality which would impact on everyone.
Looking back I now see that while it's a step in the right direction it needs to be the beginning of lots more positive change. Having been involved in this work most of my life, I have no illusions that getting here took a long, long commitment by some absolute legends who dedicated their lives to it. There are still other areas of inequality which remain shamefully and blatantly off the agenda of the powers that be, in spite of similar commitment over years. Finding the key to the next steps will be a challenge for us all.
I am still caught up in the romance of it because love won!!! All of you who played your own part, walked side by side with the LGBTI community and went out to vote YES were a part of that. Today along with other campaign teams from across the country, we celebrated our #Pride and privilege of being part of an amazing community and a life changing event in our history.
And look at the great team we had in Waterford!! (Too many to mention but you know who you are xxx)
There are some sweet memories here in the Yes Equality Gallery
Labels: #Pride, #YesEquality, Framework, Ireland, LGBTI, love, Waterford, YES Campaign 2015
Poppies, Monet and Moi
Photography is fraught with cliches. You couldn't get through a day without re-creating most of them. Even so, I'm in France, in a field of poppies and I stand awe struck and think, why not?
I'm guilty as charged when it comes to romanticising the natural world. Even though I don't enhance or photoshop at all. (I'm waiting until at least my seventies before I sit down to master that.) But maybe it's just how I want to focus on the world and what's in front of me? That for me a love of the natural world and the time to enjoy it came later in life and so it all moves me as if I'm experiencing it all for the first time?
These poppies appear to be bleached out with light and I struggle to adjust to a much lighter palette here. They are moist with dew drops in the early morning. They spread as far as the eye can see and mingle into a swathe of wild Irises in the distance.
I decide to check up on the Impressionist Artists as I imagine they all indulged in a fair bit of hazy blurry romanticism. Curiously I find that Monet one of my favourites, has used the same set of washed out orangey red and soft mossy green in his painting Poppies near Argenteuil
There are heavenly moments in photography. When everything surrounding it overwhelms the senses. The colours, the scents, the lasting impressions. These feelings live on in the images captured in that moment and can bring me back in an instant to a dewy morning in Le Val de Loire.
See more photos from France here
By Catherine Drea 16 comments
Labels: Contemplative photography, France, Le Val de Loire., Loire Valley, Monet, poppies, Red, Wildflowers
Meandering from river to river in France
This inland path is meandering from river to river, through the Loire, Vienne, Creuse, Dronne, and Charente valleys. While there hasn't been a plan or even a guide book, we have a basic map of snaking blue rivers with their most beautiful banks highlighted in green. The simplicity of this and the element of surprise around every corner has been a lot of fun.
The landscape and the villages change as we go south. From the green oak woods and strong currents of the Loire to the clear deep pools of the Dronne. From a chorus of toads each night to the cries of owls. From small gardens of organic greens to acres of vines as far as the eye can see.
Being here off peak and going inland has allowed us to experience a more quiet and peaceful side of France. (Coming from rural life in Ireland, crowds, big cities and traffic are not my idea of fun!) The back roads, rural villages and foxglove lanes of France have been a revelation. It's the land that Starbucks and the internet forgot, so finding wifi that works here is always a challenge.....
It's slow. There is no rush, no agenda, no destination. For two days we sit on a river bank enthralled by azure blue dragon flies in 30 degree temperatures; we swim in a swirling river pool, have breakfast under an ancient oak tree. Some days we roam deserted village streets, ramparts and flowering castle gardens. On others we pause, eat patisserie and browse French hardware shops (fascinating btw!).
I enjoyed the bit of teasing about posting a photo of myself and the camper van. (You know who you are and you know I don't really like to do this, but OK just this once then!!) It's a converted 5 year old VW Transporter with a pop up roof (our third camper). We had our first one in the 1970's when we drove around Europe busking and making pavement art to fund the trip, but this one is wired and plumbed!!
While it is tiny compared with the enormous camper vans here, it allows us to travel up and down boreens that those monsters couldn't attempt. To give you some idea, one of the biggest campers we have seen had a sliding door at the back revealing it's very own little smart car for running around when the giant camper got too much!!!
Back on planet river bank these few weeks feel like a deep breath in the middle of the road of life. Or maybe a kind of extended date with Himself? And now I find myself wondering if this escape could go on just a little bit longer..........
By Catherine Drea 22 comments
The scent of roses in the Loire Valley
We never know exactly where each day will end; camping on a free range duck farm, parked on the bank of a leafy river, lapping up a rose scented village. The Loire Valley has won out over the west coast and it has turned out to be a magical meandering off the beaten track.
We move slowly. No need to eat up miles or get to any particular destination, no clue what lies ahead. Every twist and turn surprises. Today it's the roses.
Of course there are castles to beat the band. But sometimes I find myself with my back to the chateau and my lens trained on the window over the boulangerie or a small side lane of cottages. Picturing who might have tended a mature rose bush and trained it over their doorway? Who planted the window boxes and gardens or lined the walls of village streets with climbers and creepers? Who cared so much, thought so creatively, worked in the heat of the sun for this beauty?
Liberty, equality and fraternity provides a basis for ordinary people to flourish. It doesn't give people any more resources but emphasises the right to belong. The valuing of each citizen makes France a country designed around social space and the importance of community. A place where ordinary people care about the country they share and here in the Loire Valley it means planting roses everywhere.
Along the route there are facilities, opportunities to share the land, understanding and empathy for the traveller. We are crisscrossing old paths used for centuries as pilgrimage routes. You would never be without sustenance or a place to sleep. Perfect for independent travellers. (I won't go on about the French public toilets, to be honest they have improved over the years and at least they have them in every village square. I was tempted to take a photo of each one I visited and rate them, but there's a terrible lack of romance in it? Suffice to say to travel off the grid you have to deal with a variety of basic challenges every day, more about all this anon)
Himself and myself have been mostly at peace with the lack of a plan. This is such a contrast with the previous few months of our lives, where every day was rigidly scheduled. If you are wondering about how it might be to come down after months of overwork and crisis management? It has been ridiculously easy! I suppose the 40 years of being on the road together helps in that......
Working around each other in a tiny camper van (VW Transporter with a pop up roof) is like being on the deck of a small boat. We manoeuvre tasks and re-organise in a space not much bigger than a large double bed. Himself being "6 foot 2 biddly-boo" has had to do more careful adjusting. Elbows, heads and toes are especially vulnerable to being clobbered.
Living in the open air wouldn't suit everyone. (We just swam in a river and later saw a snake slithering upstream!)You won't always come by a shower or a cooling breeze when you need one, and it's a constant number of repetitive tasks that keeps the whole shebang ship shape.
But if you are up for it, you will find that you are more carefree and present, more aware of the scents of the earth and more at peace in your sleep than in any fancy air-conditioned hotel.
PS I'm having a bit of an issue with uploading photos from la vie sauvage so bear with me if these are a bit wonky!!
By Catherine Drea 16 comments
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Original recipe yields 12 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Ready In
I've made this a few times and always get compliments when I make it. I use a little more tarragon than the recipe calls for, and I use egg substitute in place of the egg yolks. Great flavor!
This is my second review of this dish. The taste is good but the quantities are off. The filling is not enough for more than 6-7 crepes. I made it today again with 3 boneless chicken breas.ts...
This came out quite well- although I recommend adding a lot more tarragon- maybe twice the amount, plus dashes of salt and pepper and onion powder. We love onions here so I used about 1/2 cup o...


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7716 Views 4 Replies Latest reply: Apr 26, 2009 8:28 AM by il Jilmbo
MigUSA Jan 25, 2009 6:41 PM
Re: cannot login to wd sharespace in response to mikels460lI had the same problem and contacted WD support. They give you support for free in the US for 30 days after the first call. Unfortunately, the help was... not helpful. It seems that they don't know much about Apple's operating system. I did get to do few things done. The first one is that the Sharespace (I bought the 4Tb) should be connected to an ethernet hub and not the computer directly. I probably didn't go properly through the instructions BUT I DID NOT CLEARLY SEE THIS MENTIONED ANYWHERE!
So I connected the WD to my Time Capsule to try to use its ethernet connections as a hub. I also had to disconnect the airport to make sure (according to the help desk instructions) that the connection was hard wired. And I had to make sure that my Safari was receiving cookies (which it was).
I still cannot ping my drive and I don't like the performance that I am getting. Certainly not satisfied with the help of the WD guys (we stayed on the phone for one hour but...).
After I got tired and hung up I managed to do the following which I am recommending to you: reset the WD drive (according to WD instructions), connect to the WD (not according to their instructions using the browser/bonjour) but through Finder (where I could see the drive and used the password admin/admin), then went inside the directory CONFIGURATION and clicked on the INDEX.HTML. It will start your browser and you may have to click on the link to direct it to the entry screen. THEN I WAS ABLE TO ACCESS THE SCREEN THEY TALK ABOUT IN THE QUICK START GUIDE. After you register you are going to b able to use the drives.
I still am not happy as it seems that the NAS is very slow (I have it configured for RAID 5). I can use it but it takes a little bit of time to access even the directory names in FINDER. I also cannot ping it so I believe that there is a problem with the configuration I have. I have now my computer and the WD connected on the hub ports of the Time Capsule but definitely not happy with the support that Western Digital has for Mac users.
And I am still looking for someone that can help with the right configuration.
ElVe Jan 27, 2009 7:31 PM
Re: cannot login to wd sharespace in response to MigUSAI am having the same problem as the OP . I'd try MigUSA's solution =-- but I can't even see the drive in Finder. It's more than a little irritating.
Message was edited by: ElVe
Message was edited by: ElVe
pascalpress Apr 22, 2009 11:41 PM
Re: cannot login to wd sharespace in response to mikels460lI'm having a similar issue, although I can login to the web interface fine. My problem is that the only shares I can view from Tiger is the Configuration share. Any other shares, including the default ones (Download & Public) do not show up when I try to connect to the device.
The shares however do show up when I try to connect from a Windows PC, or from a Mac running Leopard.
il Jilmbo Apr 26, 2009 8:28 AM
Re: cannot login to wd sharespace in response to mikels460lHello everyone,
I had just the same problem as you all and solved it by choosing "connect to server" and connecting to smb://username@ipaddress (where username is the accounts username, ip address can be found in the device manager in the "network" page).
Hope this could help...


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"Put them on the back of an envelope, seal a gift bag -- or a gift diaper? Use them for a save the date card. The possibilities are numerous."
"I personalized these tags for my SIL's upcoming baby shower. She's having a little boy and I thought they were perfect for a more contemporary look."
"The pumpkin high chair stickers added a special touch to the favor bags as well as the candle holders. They matched the invitations which helped tie into the theme. Very good quality."
"I bought these to match with the shower invitations and thank you cards... for some reason my eyes skipped right over the part of the description where it said that these were actually STICKERS so I was a bit unpleasantly surprised when I opened the box, but since I'd always planned on tying these to party favors I simply used a hole punch and put a small hole in the upper left corner before threading a ribbon through it. They, and the favors they were attached to, are still being talked about as one of the cutest things the guests had ever seen."
"I ordered these stickers on a whim. I ended up using them on the birthday favors! Everyone got a bottle of wine wrapped up in foil, tied up with ribbon and I put a sticker on each one!!! It was PERFECT!!!! Everyone raved how creative I was!!"


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- Written by By Walter L Fields NNPA Columnist
This isn't about calm or order. It's about justice
This isn't about calm or order. It's about justice
After the mid-term elections, will the Congressional Black Caucus have a bigger role in setting policy
Tennessee Senator Lamar Alexander will likely become chairman of the Senate Education Committee where he would change educational services
Lauren Victoria Burke shows where the money should have been spent in the midterm election
Read more: Democrats Did Not Invest Wisely in Black Candidates
Major media outlets failed to follow up on Gary Webb's story because of CIA pressure


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Florida A&M University (FAMU) law has received full ABA accreditation — a notable turnaround after a rocky patch.
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Capital Markets
Company Overview of Bishop Street Capital Management Corp
Executive Profile
Robert Takeo Fujioka
Chief Executive Officer, Chairman, and Director, Bishop Street Capital Management Corp
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Mr. Robert Takeo Fujioka is the Executive Vice President at First Hawaiian Bank. He heads up the Commercial Banking Group, Wealth Management Group, and serves on the Senior Management Committee at First Hawaiian Bank. Mr. Fujioka is also the Chief Executive Officer, Chairman, and Director of Bishop Street Capital Management Corp. He serves as Vice Chairman and Director of Child And Family Service. Mr. Fujioka also serves on the Boards of The Japanese American National ...
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text: The ambiance is like a typical fast food joint, simple and clean. Since falafel is fast food, this is the right setting. don't expect a fancy or trendy place. The service is very nice, polite and friendly. But the real reason for the 5 stars is the food: This is the best falael I ate in... read more


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Hi, my friend loves DBZ and wants to see the episode where there past of future Trunks was showed. I tried lots of guides and she too, but we can`t find it... Can someone please tell me which ine it is?
It`s NOT 179.
It`s where the androids kill all the people and so on


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Does anyone know if it is possible to use an upgrade credit on a line to cancel another line? I have a family shared plan with 4 lines, I need to cancel 2 of the lines. One of the lines I need to cancel is still under contract, but the other is not.
No, I'm sorry, the upgrade credit can only be used towards the purchase of an upgrade. You can visit www.sprint.com/etf to learn more about early termination fees as they are on a sliding scale - the lesser number of months on the contract, the lesser the termination fee.
Check out a fun infographic that teaches you how to increase storage, enhance security,
improve battery life and clean your device.


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SparkFun Electronics will be closed on July 3rd, 2015 in observance of Independence Day. Any orders placed after 2:00pm MT on July 2nd will be shipped out after the weekend. Thanks!
Description: This is the SparkFun Vernier Interface Shield, a simple add-on to give your Arduino the capability to interface with Vernier sensors. Attached to this interface shield are four British Telecom sockets (2 Analog, 2 Digital) which all Vernier sensors use as connectors. Like any other shield, simply attach it to an Arduino development platform. This shield was developed to be used with the Arduino Uno platform but will still work with other Uno equivalents like the Leonardo or SparkFun RedBoard.
Vernier Software and Technology has been a leader in data collection and analysis for educators world-wide. They were amongst the first companies to design and promote the use of computers, sensors, and data collection in K-12 classroom laboratory experiments.
works great. would you know how to read the data from the vernier heart rate sensor? http://www.vernier.com/products/sensors/heart-rate-sensors/hgh-bta/
Based on 1 ratings:
We have older model Verniers at our college and I was thinking of having students make replacements using Arduinos and the these shields. I was able to get this working very easily, but have not tried it as a class project yet.