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Toggle, a start-up born out of the Warner Bros. Media Camp, works with big companies like Wal-Mart to deliver their streaming content.» Read More
Following are the day's biggest winners and losers. Find out why shares of Mastercard and Continental Airlines popped while Yahoo and Time Warner dropped.
If Microsoft's play for a tiny chip of Facebook helped value the company at a staggering $15 billion, then AOL's play for social networking site Bebo makes perfect sense, even at $850 million.
Time Warner's AOL Internet division said Thursday it will buy social network Bebo for $850 million in cash, bolstering its consumer Internet offerings even as the media conglomerate mulls splitting off the business.
The technology industry thrives on its ability to sell new products to consumers at an ever-increasing pace. But millions of users of nearly every type of Internet service and technology, from Netscape and AOL dial-up to old e-mail systems, still cling to older technologies.
On Tuesday, Time Warner's chief executive of Time Warner, AOL's parent company, acknowledged weakness in the online pioneer's business and said he was open to combining AOL with another company.
The president and chief executive of the Walt Disney Company says his company is not recession-proof, but it is positioned well enough to avoid being badly hurt in an downturn.
Rupert Murdoch CEO of News Corp, spoke at Bear Stearns annual media conference today, weighing in on the U.S. economy. He said he's now "more pessimistic" about the economy. Though he also said that News Corp is well positioned to weather an economic downturn because only about 20 percent of the company's business comes from advertising...
ShoWest--the annual conference for movie distributors (divisions of media companies) and exhibitors (movie theater chains)--is underway in Las Vegas. This is where the movie studios show off their big products they hope will be blockbusters to get the theater owners excited to fill their seats.
After years of grand jury testimony, the trial of Anthony Pellicano, erstwhile private eye-to-the-stars, starts this week. Jury selection is underway in downtown Los Angeles.
The Dow snaps a losing streak as oil hits another all-time high. Get the news behind the headlines in the Word on the Street.
When in doubt, delay! That appears to be the strategy at Yahoo, where the company's board has authorized a deadline extension for outsiders to nominate their own slate of directors, which would have been next week. The new deadline will now be 10 days after the company announces the date of its annual shareholder meeting. This clock indeed is ticking...
Yahoo has extended a deadline for nominating candidates to its board, giving the struggling Internet pioneer more time to search for a white knight to help it fight off an unwanted takeover bid from Microsoft.
Yahoo and media conglomerate Time Warner have stepped up talks to create an alternative to Microsoft's offer to take over the Web company, the Wall Street Journal reported on Wednesday citing people familiar with the matter.
How do you profit as the business of print starts to perish?
Will Ferrell stumbled at the North American box office Sunday with his latest sports comedy, "Semi-Pro." The basketball spoof narrowly took the No. 1 spot with disappointing ticket sales of $15.3 million, its struggling distributor New Line Cinema said
Time Warner's new CEO, Jeff Bewkes just showed Wall Street that he means business about cost cutting and getting the company on track. He just made his first big move-- consolidating Time Warner's New Line studio into its separate and larger Warner Bros.
Banks begin reporting earnings March 10th. Will they issue warnings of further write-downs this week ahead of earnings? Also, your retail trades and options action in Cogent.
The 80th Annual Academy Awards brought the glamour and champagne back to Hollywood after a grim 100-day strike. John Stewart cracked the requisite jokes about the work stoppage -- calling the Oscars the "makeup sex" for the industry.
The new assassination thriller "Vantage Point" shot to the No. 1 spot at the weekend box office in North America while Oscar nominees "Juno" and "There Will Be Blood" enjoyed solid sales ahead of Sunday's Academy Awards ceremony.
You'd think the Academy Awards were controlled by studio moguls or movie stars. But the guys really holding the cards -- literally -- are a couple of accountants. Forget about George Clooney and Will Smith -- without Price Waterhouse Coopers, the show couldn't happen.


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Drink between: 2008 - 2015 (Add My Dates)
Tasted non blind.
Purple color in the glass, slightly dusty looking. Nose of kirsch, fertilizer, tobacco and plum. Flavors of berries, cherries and plums. Medium acidity, medium tannin, full bodied. Drink or hold.
Russk 90+
PnP very rich, dark flavors. Beautiful nose. Tasted great right after opening, hit a lull after 20 minutes but found a beautiful balance about an hour/hour and a half after opening. Next time I might slow ox for an hour or two
Black cherry on the nose. Also a little run raisin ice cream. Mild wood. A lot of fruit going on with the nose. Also a fair amount of spice going on.We drank this wine without a decant. Opened and let sit for 30 minutes. Then poured and it was in a good place. I don't think that this requires a decant. Enjoy this wine now and the coming year or two. It is in a good place.
Will keep for a little longer - still quite tannic - Have 6 but tasted at a friends

subset: commoncrawl


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Majestic Sun 1106A
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4 Bedroom | 3 Bath | Gulf-view 2-Story Penthouse Condo | Sleeps 14
Majestic Sun Vacation Rental Condominium
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Be one of the first to have a magnificent beach vacation in this completely refurbished Majestic Sun Penthouse! This two-story penthouse boasts over 3,300 square feet of vacation bliss, and over 1,000 additional feet of spacious balcony to bask in the gorgeous Gulf views! Travertine tile floors, floor-to-ceiling glass doors, and upgraded features throughout create a rich and inviting space with room for everyone to relax and rejuvenate. Enjoy the gourmet kitchen with granite counter tops, the over-sized wet ...Read more
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Publications (9)26.82 Total impact
- SourceAvailable from: José Ignacio Martínez
Dataset: COVER ART: Density functional theory based screening of ternary alkali-transition metal borohydrides: a computational material design project
Article: Universal Transition State Scaling Relations for Hydrogenation and Dehydrogenation Reactions over Transition Metals
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ABSTRACT: We investigate the heterogeneously catalysed oxidation of HX (X=Cl, Br and I) on the RuO2 (1 1 0) surface with DFT. We also solve a micro‐kinetic model of HX oxidation and compare oxidation activity at different coverages. We further establish linear energy relations for the reaction intermediates over a range of different rutile oxide surfaces. Based on the scaling relations, two descriptors are identified that describe the reactions uniquely. By combining scaling with the micro‐kinetic model, activity volcanoes for the three different oxidation reactions are derived. It is found that the commonly used RuO2 catalyst for HCl oxidation is closest to optimal for all three oxidation processes.ChemCatChem 11/2012; 4(11). DOI:10.1002/cctc.201200140 · 5.04 Impact Factor
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ABSTRACT: We analyse the transition state energies for 249 hydrogenation/dehydrogenation reactions of atoms and simple molecules over close-packed and stepped surfaces and nanoparticles of transition metals using Density Functional Theory. Linear energy scaling relations are observed for the transition state structures leading to transition state scaling relations for all the investigated reactions. With a suitable choice of reference systems the transition state scaling relations form a universality class that can be approximated with one single linear relation describing the entire range of reactions over all types of surfaces and nanoclusters.Physical Chemistry Chemical Physics 12/2011; 13(46):20760-5. DOI:10.1039/c1cp20547a · 4.20 Impact Factor
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ABSTRACT: Versatile Brønsted-Evans-Polanyi (BEP) relations are found from density functional theory for a wide range of transition metal oxides including rutiles and perovskites. For oxides, the relation depends on the type of oxide, the active site, and the dissociating molecule. The slope of the BEP relation is strongly coupled to the adsorbate geometry in the transition state. If it is final state-like the dissociative chemisorption energy can be considered as a descriptor for the dissociation. If it is initial state-like, on the other hand, the dissociative chemisorption energy is not suitable as descriptor for the dissociation. Dissociation of molecules with strong intramolecular bonds belong to the former and molecules with weak intramolecular bonds to the latter group. We show, for the prototype system La-perovskites, that there is a "cyclic" behavior in the transition state characteristics upon change of the active transition metal of the oxide.The Journal of Chemical Physics 06/2011; 134(24):244509. DOI:10.1063/1.3602323 · 3.12 Impact Factor
Conference Paper: Bronsted-Evans-Polanyi relations for transition-metal oxides from density functional theory241st National Meeting and Exposition of the American-Chemical-Society (ACS); 03/2011
Article: Density functional theory based screening of ternary alkali-transition metal borohydrides: a computational material design project.[Show abstract] [Hide abstract]
ABSTRACT: We present a computational screening study of ternary metal borohydrides for reversible hydrogen storage based on density functional theory. We investigate the stability and decomposition of alloys containing 1 alkali metal atom, Li, Na, or K (M(1)); and 1 alkali, alkaline earth or 3d/4d transition metal atom (M(2)) plus two to five (BH(4))(-) groups, i.e., M(1)M(2)(BH(4))(2-5), using a number of model structures with trigonal, tetrahedral, octahedral, and free coordination of the metal borohydride complexes. Of the over 700 investigated structures, about 20 were predicted to form potentially stable alloys with promising decomposition energies. The M(1)(Al/Mn/Fe)(BH(4))(4), (Li/Na)Zn(BH(4))(3), and (Na/K)(Ni/Co)(BH(4))(3) alloys are found to be the most promising, followed by selected M(1)(Nb/Rh)(BH(4))(4) alloys.The Journal of Chemical Physics 08/2009; 131(1):014101. DOI:10.1063/1.3148892 · 3.12 Impact Factor
Article: Scaling Relationships for Adsorption Energies on Transition Metal Oxide, Sulfide, and Nitride SurfacesAngewandte Chemie International Edition 06/2008; 47(25):4683-6. DOI:10.1002/anie.200705739 · 11.34 Impact Factor
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ABSTRACT: Introduction The formation of a bond between a molecule and a metal surface is an important phenomenon in a number of processes including heterogeneous catalysis [1], contact formation in molecular electronics [2], and anchoring of biomolecules to solids for sensors and other biomedical applications [3]. The adsorption energy is a key quantity describing the strength of the interaction of molecules with the surface. The adsorption energy can be measured by advanced surface science techniques [4-6]. Alternatively, density functional theory (DFT) offers the possibility of calculating adsorption energies with reasonable accuracy [7-11]. While both experiments and DFT calculations are feasible for a limited number of systems, they can hardly be performed in detail for all potentially interesting adsorption systems, thus complicating the search after for example new heterogeneous catalysts. There is therefore a need for simple models with the ability to estimate bond energies in a first screening of interesting systems [12]. Such a model for hydrogen-containing molecules adsorbed on transition metal surfaces has recently been presented [13], and was shown to be useful in the design of transition metal-containing surface alloys for selective hydrogenation catalysis [14]. While linear energy relations thus are omnipresent and extremely useful in the field of transition metal catalysis, they have not historically played a significant role in the interpretation or oxide or zeolite catalysis. Recently, it is shown that a number of linear energy relations rather surprisingly could be straight-forwardly generalized to the surfaces of more complex compounds such as oxides, sulphides, and nitrides [15]. We here address that observation in more detail, with a focus on the adsorption properties of zeolites. Methods Throughout we apply density functional theory calculations in a plane wave pseudopotential approach, as implemented in the DACAPO package. The full zeolite framework is represented in the calculation, and the exchange-correlation description is RPBE.
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Technical University of Denmark
Lyngby, Capital Region, Denmark
- • Department of Physics
- • Center for Atomic-scale Materials Design


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Very busy in films of the 1920s, handsome, mustachioed John Roche specialized in playing the "other man," the slick sweet talker who never gets the girl. Onscreen from 1922, the tall, Rochester-educated actor had spent ten years touring with various stock companies. He returned to the legitimate stage in the early '30s but was back in Hollywood playing bit roles by 1942. ~ Hans J. Wollstein, Rovi


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Investigations of gene-environment interaction (G × E) in depression have implicated a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-depression relationship. However, recent evidence for 5-HTTLPR G × E in depression has been inconsistent. The present study examined the moderating effect of the val158met polymorphism in the catechol-O-methyltransferase (COMT) gene on the strength of 5-HTTLPR G × E.
A community sample of youth (n = 384) was genotyped for 5-HTTLPR and COMT. A multi-method, multi-informant index of chronic family stress was derived from interviews and questionnaires administered at youth age 15. G × G × E was examined in relation to depression diagnoses between ages 15 and 20 and depressive symptoms at age 20.
Significant three-way interactions were observed for both depressive symptoms and diagnoses, such that 5-HTTLPR G × E occurred only in the context of COMT val158 allele homozygosity. For val158 homozygotes, the 5-HTTLPR L allele exerted a protective effect in the face of stress. No genetic main effect or two-way G × E was found for 5-HTTLPR.
Inconsistent 5-HTTLPR G × E findings to date may be partly attributable to unmeasured epistatic effects between 5-HTTLPR and COMT val158met. Identifying the conditions under which 5-HTTLPR G × E is most likely to operate may allow depression prevention and treatment efforts to target youth at highest risk.
Most depressions are preceded by stressful experiences [1], yet only one in five people becomes depressed following a severe stressor [2]. Considerable attention has focused on identifying biological and psychosocial factors that account for the interindividual variability in depressive responses to stress [3–5]. At the biological level, variation in a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) is a putative moderator of the stress-depression relationship. In the original report, Caspi and colleagues [6] observed that the short (S) allele at 5-HTTLPR conferred risk for depression in the face of stress, whereas long (L) allele homozygotes were resilient to stressful life events.
More than 15 studies [reviewed in 7] have provided at least partial support for Caspi et al.'s [6] findings. Recently, however, researchers have cautioned that the 5-HTTLPR gene-stress interaction (G × E) may not be as robust as initially thought [8]. Inconsistent findings have emerged, as various studies failed to find evidence of G × E [9–13], and others reported interaction effects in the opposite direction to that observed by Caspi et al. [14,15]. These discrepancies were highlighted by two recent meta-analyses that concluded 5-HTTLPR G × E has a negligible effect on depression vulnerability [16,17].
Recent reviews, however, have affirmed the validity of G × E modeling and observed multiple replications of the original Caspi et al. findings, noting a number of measurement and methodological requirements that should be met [18–20]. One additional explanation for inconsistent findings is that emotional reactivity to stressful contexts is controlled by multiple genes [21], with some variants augmenting the stress response and others attenuating it. From this perspective, the effect of 5-HTTLPR on vulnerability (or resilience) to depression following exposure to stressors likely depends on variation at other susceptibility loci.
Several studies have implicated gene-gene interplay (i.e., epistasis) involving 5-HTTLPR in serotonin transporter expression [22,23], morphology of limbic circuitry [24], and a variety of behavioral phenotypes, including traits relevant to stress reactivity (e.g., negative affectivity, harm avoidance) [25–28]. These findings suggest that examining epistatic effects may help demarcate the conditions under which 5-HTTLPR G × E is most likely to operate.
Investigations in healthy samples have established an association between the catechol-O-methyltransferase (COMT) gene and sensitivity to experimental stress [29–31], supporting COMT as a plausible candidate for G × E [32]. The COMT gene contains an extensively studied G>A single nucleotide polymorphism (SNP) (rs4680) that results in a valine (val) to methionine (met) amino acid substitution commonly known as val158met. The met158 allele produces a heat-labile enzyme that is associated with a three- to four-fold reduction in degradation of dopamine in the synapse [33].
Inconsistent results from genetic association studies call into question whether COMT exerts a direct effect on risk for depression. Both met158 [34] and val158 [35,36] alleles have been linked to depression, but other studies have reported null associations [37–39]. It has been suggested COMT influences risk for affective disorders in conjunction with environmental stress [40]. The COMT met158 allele is thought to confer vulnerability to stress because it is associated with increased stress hormone release [29,30], as well as greater sensory and affective ratings of pain [31], in response to physical and psychological stressors. Additionally, the met158 variant is consistently linked to increased activation in the amygdala and hippocampus, as measured by functional magnetic resonance imaging (fMRI), following exposure to unpleasant and emotional visual stimuli [41–43]. COMT-mediated dopamine increases in limbic regions are hypothesized to result in enhanced arousal and exaggerated affective responses to environmental stressors [40]. A "case-only" study of Italian inpatients diagnosed with affective disorders [44] offered preliminary evidence that the met158 allele increases susceptibility to depression following adverse events.
The present study examined the moderating effect of COMT genotype on 5-HTTLPR × chronic stress interactions in an Australian community sample of adolescents. Exposure to chronic family stress was indexed by a multi-method, multi-informant composite score from age 15 assessments. Depressive symptoms and diagnoses were assessed five years later at youth age 20. A gene-gene-environment interaction (G × G × E) was predicted such that the strength of 5-HTTLPR G × E would depend on COMT genotype. Specifically, carriers of both the 5-HTTLPR S and COMT met158 alleles were predicted to exhibit the greatest depressive response to chronic stress, whereas those homozygous for L and val158 alleles were predicted to be least reactive to stress.
Participants were recruited from the Mater-University Study of Pregnancy (MUSP), which followed a birth cohort of 7,223 mothers and their offspring born between 1981 and 1984 in Brisbane, Australia [45]. Mothers completed the Delusions-Symptoms-States Inventory [DSSI; 46] during pregnancy, post-partum, 6 months after birth, and 5 years after birth. As described in detail elsewhere [47], the present study selected and followed up 815 of the original families when the child reached age 15, oversampling for mothers with a putative history of depression based on the severity and chronicity of depressive symptoms endorsed on the DSSI whose diagnostic status was later confirmed. The sample studied at age 15 was 92% Caucasian and 8% minority (Asian, Pacific Islander, and Aboriginal), with median family income falling in the lower middle class and mothers' median education level at grade 10. At youth age 20, all families were invited to participate in a second assessment, yielding a sample of 705 youth and mothers that agreed and completed further interviews and questionnaires [see 48 for details].
Of the 705 youth assessed at age 20, 512 provided blood samples between ages 22–25. Participants not providing DNA either had withdrawn from follow-ups, declined the current study, moved, had major medical problems, or were deceased. The 512 participants in the genotyping sample at ages 22–25 did not differ from the 303 participating at age 15 but not at ages 22–25 in terms of youth depression history by age 15 or maternal history of depression by age 15, χ2 s < 1, ps > .10, but were less likely to be male, χ2(1, 815) = 21.29, p < .01.
The current analyses are based on 384 randomly selected DNA samples from the 512 participants who provided blood because funding was available for only one 384-well genotyping plating. Three samples failed to produce an adequate reading, resulting in current analyses based on 149 males and 232 females, mean age 23.7 (SD = 0.89). Comparing the 381 youth for whom COMT and 5-HTTLPR genotype were determined with the 131 youth whose DNA samples were unanalyzed, there was no difference in maternal depression status, χ2(1, 512) < 1, p > .10, although males were less likely to have their sample analyzed than females, χ2(1, 512) = 16.49, p < .001. Stratified by genotype group, descriptive statistics for the main study variables are presented in Table 1.
At youth age 15, participants were visited in their homes. Interviewers who were blind to the mother's depression status conducted separate and independent interviews with youth, mothers, and available fathers. The mother-child pairs were again assessed at age 20 and the youth were contacted in 2006 for participation in the genotyping study when they were between ages 22 and 25. Procedures were approved by the Institutional Review Boards of the University of Queensland; University of California, Los Angeles; and Emory University.
Self-reported depressive symptoms at age 20 were assessed using the Beck Depression Inventory-II [BDI-II; 49], a well-validated and extensively used measure of severity of depressive symptoms. Reliability for the current sample was α = 0.92.
Youth diagnoses of major depression and dysthymic disorder between ages 15 and 20 were assessed using the Structured Clinical Interview for DSM-IV [SCID; 50] administered at age 201. The SCID allowed precise dating of depressive disorders to ensure onsets occurred after the age 15 assessment. Diagnostic reliability estimates based on 10% of the interviews rated by independent judges were κ = 0.83 for current diagnoses of depression and κ = 0.89 for past depression.
Maternal depression during the child's lifetime prior to age 15, used as a covariate in all analyses, was assessed by SCIDs administered to mothers at youth age 15. Youth current and past depression diagnoses at age 15 were also ascertained using the SCID.
A composite family stress variable was derived from a battery of 11 self-report and interview measures completed at age 15 pertaining to marital and parental functioning. A variety of indicators of family stress was collected in order to adequately capture aspects of both the marital and parent-child relationship, as well as incorporate multiple informants (i.e., parent, youth, interviewer) and methods (i.e., self-report questionnaire, interview). Three measures were interviewer-rated scores from the youth and mother versions of the UCLA Chronic Stress Interview [51] covering quality of mother's marital/romantic relationship, her relationship with the youth, and the youth's relationship with immediate family members. Intraclass correlations based on independent ratings of these domains were 0.82, 0.82, and 0.76, respectively. Validity data for adults and youth are reported elsewhere [51,52].
To assess overall marital relationship quality, the Satisfaction subscale of the Dyadic Adjustment Scale [DAS; 53] was administered to mothers who were in relationships, as well as husbands when available. Mothers and fathers also completed the Modified Conflict Tactics Scale [MCTS; 54] assessing psychological and physical coercion (e.g., argued heatedly; refused to talk; threw something; hit partner). Cronbach's α for the DAS and MCTS ranged from 0.80–0.95 and 0.79–0.92, respectively, across parents.
The Children's Report of Parental Behavior Inventory [CRPBI; 55] was administered to youths to assess the quality of their interactions with both parents. The psychological control versus psychological autonomy and youth's perception of acceptance versus rejection were the two subscales of the CRPBI used in the current analyses. Internal consistency for each subscale by parent ranged from 0.77–0.91.
Each of these 11 measures was standardized across the sample and non-missing variables for each participant were averaged to form a composite (α = 0.78). Scores ranged from -1.25 to 1.99 (M = 0.01, SD = 0.57), with higher values indicating greater family stress.
Participants who agreed to the blood collection study were mailed consent forms, a blood collection pack, and questionnaires, and were instructed to have the blood drawn at a local pathology lab. The blood samples were picked up by courier from the individual and transported to the Genetic Epidemiological Laboratory of the Queensland Institute of Medical Research, where the genotyping procedures were conducted.
Assays for the COMT val158met SNP were designed using MassARRAY Assay Design software (version 3.0; Sequenom Inc., San Diego, CA) and typed using iPLEX chemistry on a Compact MALDI-TOF Mass Spectrometer (Sequenom). Forward and reverse PCR primers and a primer extension probes were purchased from Bioneer Corporation (Daejeon, Korea). Genotyping was carried out in standard 384-well plates with 12.5 ng genomic DNA used per sample. A modified Sequenom protocol was followed, using half reaction volumes in each of the PCR, SAP and iPLEX stages giving a total reaction volume of 5.5 μL. The iPLEX reaction products were desalted by diluting samples with 18 μL of water and 3 μL SpectroCLEAN resin (Sequenom) and then were applied to a SpectroChip (Sequenom), processed and analyzed on a Compact MALDI-TOF Mass Spectrometer by MassARRAY Workstation software (version 3.3) (Sequenom). Allele calls for 384-well plates were reviewed using the cluster tool in the SpectroTYPER software (version 3.3; Sequenom) to evaluate assay quality. In the present sample, genotype frequencies (and corresponding proportions) at val158met were VV = 91 (.24), VM = 195 (.51), MM = 95 (.25), and were in Hardy-Weinberg Equilibrium, χ2 (1, 381) = 0.04, p = 0.83.
The 5-HTT 43 bp deletion polymorphism was assayed using previously reported methods [56]. Most samples were subject to triplicate gel analysis. A minimum of two independent results in agreement was required for inclusion which gave a final call rate of 96.4%. In the present sample the genotype frequencies (and proportions) were LL = 122 (.32), LS = 178 (.47), and SS = 81 (.21), and in Hardy-Weinberg equilibrium, χ2 (1, 381) = 1.61, p = 0.20.
The minor allele of the rs25531 SNP in the L allele has been reported to render the L allele functionally equivalent to S [23]. This SNP was assayed using the protocol of Wray et al.[56], and the current analyses were performed reclassifying LG alleles as S.
The effects of 5-HTTLPR, COMT, chronic family stress, and their two- and three-way interactions on age 20 depressive symptoms (BDI) were estimated using ordinary least squares (OLS) regression. Gender, maternal depression history, and youth depression history at age 15 were included in the model as covariates. One dummy variable was created to represent the contrast of the LL group versus SS and SL groups, consistent with past research on 5-HTTLPR and stress reactivity [57]. Similarly, met158 carriers were grouped and contrasted with val158 homozygotes in accordance with prior research [e.g., 44].
Given these groupings, four genotype combinations were possible: S allele carriers and met158 allele carriers (hereafter SM), S allele carriers and val158 homozygotes (SV), L homozygotes and met158 allele carriers (LM), and L homozygotes and val158 homozygotes (LV).
Using an estimated effect size of ΔR2 = .02 drawn from previous G × G × E research [58], a Type I error rate of 0.05, and a desired power level of 0.80, power analyses in Stata 10.0 [59] indicated that 324 observations were needed to detect a 3-way interaction between 5-HTTLPR, COMT, and family stress, given that one exists.
The same set of predictors was entered in a logistic regression model with youth depression onset between years 15 and 20 as the outcome variable. OLS and logistic regression parameters were compared to confirm that any observed interactions were not artifacts of measurement scale [32]. For both models, when interactions were detected, simple effects were calculated using the LINCOM command in Stata 10.0 [59]. Simple effect p-values (denoted padj) were adjusted following procedures formulated by Benjamini to control the False Discovery Rate for correlated test statistics [60].
Univariate analysis of variance revealed no main effects of 5-HTTLPR, F(1, 356) = 0.57, p = .45, or COMT val158met, F(1, 356) = 1.63, p = .20 on exposure to family stress, nor was there any joint effect of 5-HTTLPR and COMT, F(1, 356) = 1.38, p = .24.
Predictors were entered hierarchically, with main effects on Step 1, two-way interactions on Step 2, and the three-way interaction on Step 3. A significant main effect of chronic family stress was observed on Step 1, whereas neither 5-HTTLPR nor COMT exerted a direct effect on BDI (see Table 2). The addition of the two-way interactions on Step 2 did not account for a significant increment in variance explained, ΔR2 = .006, ΔF(3, 332) = 0.81, p = .49, indicating no G × E. In contrast, on Step 3, the three-way interaction term was significant, b = −11.04, SE = 3.73, p < .01.
For the LV group, the slope of BDI scores on chronic family stress was not significantly different from 0, b = −3.25, SE = 2.50, padj = .24. All other genotype groups exhibited significant positive slopes of BDI on chronic stress (SV, b = 6.75, SE = 1.80, padj < .05; SM, b = 3.84, SE = 1.06, padj < .05; LM, b = 4.88, SE = 1.88, padj < .05) (see Figure 1). Further, the slope of the LV group was significantly different from the slopes for the other three genotype groups (all padjs < .05) whereas the three groups with nonzero slopes did not differ from each other in terms of strength of the chronic stress-BDI association (all padjs > .10).2
As in the linear model, variables were entered hierarchically into the regression. In Step 1, 5-HTTLPR and COMT did not significantly affect the probability of being diagnosed with depression between ages 15 and 20, whereas increasing stress was associated with a greater likelihood of depression (see Table 3). On Step 2, there was no effect of the two-way interactions, taken together, on depression risk, χ2 (3) = 0.24, p > .10. Consistent with the OLS model, on Step 3 the three-way interaction term was significantly less than 0, b = −2.40, SE = 1.13, Wald = 4.41, p < .05. As shown in Figure 2, the form of this interaction was nearly identical to that observed in the OLS model. Again, the LV group was resilient to increasing stress, b = −0.62, SE = 0.73, z = −0.85, padj = .39. In contrast to the LV group, all other genotype combinations showed a positive relationship between chronic family stress and likelihood of depression; however, p-values of all the corresponding simple slopes fell short of significance after adjustment for multiple testing (LM, b = 1.30, SE = 0.61, padj = .13; SV, b = 0.83, SE = 0.55, padj = .27; SM, b = 0.37, SE = 0.29, padj = .28).3
The current study examined the joint effect of 5-HTTLPR and COMT val158met on depressive reactions to chronic stress in a sample of young adults. COMT genotype previously linked to stress sensitivity [30,31] and depressive disorders [34–36] was found to alter the strength of 5-HTTLPR G × E. Specifically, 5-HTTLPR G × E was observed only among val158 homozygotes. In the context of val158 homozygosity, the 5-HTTLPR LL genotype was associated with resilience to stress, relative to the SL and SS genotypes. However, in the presence at least one met158 allele, both 5-HTTLPR genotype groups were vulnerable to depressogenic stressors.
These results are consistent with past investigations that have linked the 5-HTTLPR S and COMT met158 variants to emotional reactivity to environmental stress [see 7,44]. The presence of at least one of these susceptibility alleles was sufficient to increase risk for depression in response to stress. On the other hand, the current findings do not support the view that 5-HTTLPR L homozygotes are immune to pathogenic environments. When paired with a met158 allele, L homozygosity provided no protective effect against chronic stressors. This pattern of results may be attributable to heightened affective arousal experienced by carriers of the S or met158 allele when confronted with stressful conditions [40,41]. The presence of either one of these variants has been shown to be sufficient to increase neural and psychophysiological reactivity to aversive cues [40,57].
Contrary to hypotheses, the met158 allele did not potentiate the effect of the S allele on depressive reactivity. Biological mechanisms underlying the lack of additivity between met158 and S are unclear, but may be elucidated by future research into the interaction of serotonergic and dopaminergic neurotransmitter systems [e.g., 61,62].
The current G × G × E findings may be relevant to some discrepancies among existing reports of 5-HTTLPR G × E. Some studies have failed to replicate the G × E observed by Caspi et al. [6], and recent null meta-analytic findings [16,17] have called attention to this inconsistency [cf. 18–20]. Indeed, in the current analyses the moderating effect of 5-HTTLPR was detected only when COMT and 5-HTTLPR were analyzed simultaneously. Thus, one of several possible explanations for conflicting results in the literature is that the nature of 5-HTTLPR G × E is dependent on the background of other genes, including COMT, regulating sensitivity to stress.
The present results should be considered preliminary in light of the limited sample size available for the genetic analyses. The group homozygous for the L and val158 alleles, in particular, was relatively small (n = 29). Thus, it is possible that this study was underpowered to detect a significant effect of family stress in this group, although there was no evidence of a trend in this direction. This is potentially important given that the null stress-depression association in the LV group, relative to the strong depressogenic effect of stress obtained in all other genotype combinations, appeared to account for the observed G × G × E. It is possible that results could differ in larger samples, and conclusions should be considered tentative until replications from large-scale studies, with more representative samples of all genotype combinations, are available.
Several other limitations of the present study should be noted. First, depression outcomes were assessed over a limited age range (i.e., late adolescence). This may be an important qualification of the results in light of apparent fluctuations in G × E across developmental stages [14,63]. Second, the current study controlled for gender, but future studies with sufficiently large samples should explore whether complex gene-gene interactions may apply differently for males and females [64,65]. Third, sample size limitations prevented a thorough investigation of the role of heterozygosity at 5-HTTLPR and COMT. Further research is necessary to determine whether additive, dominant, or recessive models for these loci are most appropriate for G × E designs. Finally, rGE presents potential complications in the interpretation of G × E in studies of measured genes and measured environments [32]. In the present sample, tests for rGE indicated that exposure to chronic family stress was not associated with genotype. However, it is implausible that the family context is entirely independent of genetic contributions, so the possibility remains that some portion of the observed interactions reflects unmeasured G × G.
Future research is necessary to explore the mechanisms, timing, and continuity of stressors in 5-HTTLPR G × E. In the current study, chronic stress was assessed 5 years prior to the self-reported depressive symptoms. The plausibility of G × E operating over this interval is supported by evidence suggesting relatively high stability of chronic stress exposure over time [66]. However, given the association of chronic stress in adolescence with early childhood adversity as well as acute stressors proximal to the age 20 assessment [66], it remains to be seen whether chronic family stress exerts a unique influence in 5-HTTLPR G × E [see 63]. Future studies using psychometrically-sound measures of acute stress and early adversity are needed to explore the range of G × E effects involving 5-HTTLPR and COMT.
In sum, these preliminary results raise the possibility that the effect of 5-HTTLPR on depressive reactivity to life stress may be more reliably detected by simultaneously accounting for variation in other monoaminergic genes that underlie stress reactivity. The current findings of complex gene-environment interplay await replication in future research involving large samples. By identifying the biological and psychological moderators of 5-HTTLPR G × E, the conditions in which G × E is most likely to operate can be better understood.
The authors greatly appreciate the assistance of Robyne LeBrocque, Cheri Dalton Comber, and Sascha Hardwicke (project coordinators) and their interview staff. We also thank staff of the Genetic Epidemiological Laboratory of the Queensland Institute of Medical Research: Professor Nick Martin (Head) for cooperation and access, Michael James for 5-HTTLPR genotyping, and Megan Campbell and Dixie Statham who coordinated genetic data collection and analysis. Thanks also to the original MUSP principals, William Bor, MD, Michael O'Callaghan, MD, and Professor Gail Williams. This study was supported by NIMH R01 MH52239 to Brennan, Hammen, and Najman.
Financial Disclosures
The authors report no biomedical financial interests or potential conflicts of interest.
1There were only 4 onsets of dysthymia between age 15 and age 20. Results were unaltered when these cases were omitted from the analyses.
2Exploratory analyses were performed using an additive model for 5-HTTLPR, coding a single variable with values of 0, 1, and 2 to represent the number of S alleles present. The three-way interaction remained significant in predicting depressive symptoms, b = −6.05, SE = 2.72, z = −2.22, p < .05. The slope of depression on stress was comparable in the SS and SL groups (ps < .05), regardless of COMT genotype, consistent with the dominant model of the 5-HTTLPR S allele adopted in the original analyses.
3Follow-up analyses were performed exclusively in a subsample of 354 Caucasian participants (i.e., 93.0% of the genotyped sample) to ensure that ethnic stratification did not affect the findings. Results from the OLS model revealed that the 3-way interaction remained significant, b = −10.35, SE = 4.01, z = 4.02, p < .01. Similarly, the strength of the G × G × E in the logistic model was not affected, b = −2.66, SE = 1.16, z = −2.29, p < .05. Further, the nature of these interactions was equivalent to that observed in the full sample; in all cases the significance of simple slopes was unchanged.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Welcome to Forepaugh's Restaurant
Here at Forepaugh's, you and your guests will enjoy award winning American Cuisine and service excellence in a historic and charming 19th-century setting. Whether it's a romantic dinner on our rooftop terrace, a burger and beer in our cozy bar, Sunday brunch on the porch, a wedding banquet on third floor, happy hour on the patio, or a business dinner in the wine cellar…
We invite you to experience all that is fabulously Forepaugh's!
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Forepaugh's will be closed on Saturday and Sunday, July 4th and 5th in order to give our dedicated staff a well deserved weekend off. We wish you and yours a safe and fun filled holiday weekend!What's cooking
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We are passionate about exceptional everything. Food. Wine. Service. Ambiance. The whole experience. From our welcoming Maitre d' and professional staff to our talented chefs, committed managers and owner, our goal is one in the same: to inspire!Read about us
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Sure, we are known for our Beef Wellington, but the Cuban on our Downstairs menu is equally delicious! Yes, we have been a Wine Spectator Award Winner, but we also make a mean martini. We do banquets AND brunches. Forepaugh's has a menu for you!View our menus


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MAC Design for Analog Network Coding
Date Added: Aug 2010
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Most medium access control mechanisms discard collided packets and consider interference harmful. Recent work on Analog Network Coding (ANC) suggests a different approach, in which multiple interfering transmissions are strategically scheduled. The received collisions are collected and then used in a decoding process, such as the ZigZag decoding process, where the packets involved in the collisions are extracted. In this paper, the authors present an algebraic representation of collisions and describe a general approach to recovering collisions using ANC.


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An analysis of an interconnection network for packet switching controlled by a neural network is presented. The interconnection network is a crossbar switch of size N which maintains N queues at each of the inputs. The neural net controller is of the Hopfield type, and performance evaluation is done under realistic input traffic assumptions. In order to investigate the influence of the random characteristics of the packet traffic on the neural net performance, the offered packet streams are modeled by means of batch inputs, where the inter-arrival time and the packet length can be arbitrarily chosen. The incoming traffic indicating source-destination packet stream is symmetrically distributed over the crosspoints of the interconnection network. Simulation results for various system parameters are presented with respect to the performance measures, such as switch throughput and transfer delay. The performance of the neural net as switch fabric controller is compared to conventional control schemes, where the issue of scheduling fairness is addressed
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Home » Egg Donors
You've heard the term and have perhaps enjoyed a micro-brew yourself, but what does the term "Craft Beer" even mean? The short answer is that craft beers are made in small batches using time-honored methods. They create a total-bodied aroma and taste that is really unique for their brew. Across the globe, there are several various explanations of the creates a accurate craft brewer. However the Brewers Association has come up with a def
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Articles tagged casiotone for the painfully alone
28 Apr 2010 // 9:00 AM
One of indie-pop's most talented and underrated songwriters reminds us that more is sometimes better.READ more
12 Mar 2009 // 10:00 PM
Chicago's battery-powered bard serves up a solid singles collection in advance of his fifth full-length.READ more
4 Dec 2008 // 8:57 PM
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Owen Ashworth's indie flick soundtrack is a diverting curiosity if not an essential addition to his already impressive back catalogue.READ more
29 Mar 2006 // 12:00 AM
Recently upgraded to mid-fi production and displaying more varied arrangements, Casiotone for the Painfully Alone's latest is probably his best, more accessible without sacrificing any of his sharp-witted observational lyricism.READ more
16 Dec 2002 // 11:00 PM
Casiotone for the Painfully Alone is not only a clever band name but an apt one. First, Owen Ashworth, who is the band here, doesREAD more
Colette Carr "Static" (video) (Premiere) // Music
House of Blondes "First of July" (audio) (premiere) // Music
Digisaurus 'No More Room For Love' (EP stream) // Music
Eszter Balint 'Airless Midnight' (album stream) (premiere) // Music
PopMatters is on a short summer publishing break. We resume Monday, July 6th.
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Christmas shopping and warm beds in Copenhagen all decorated for Christmas
Experience the very special Christmas cosiness with the yearly Christmas market along the dock of Nyhavn and spend the night in the wonderful Hotel Copenhagen Strand on the harbour front. McJoy's Pub in Nyhavn will restore your warmth in form of homemade mulled wine, cookies and live music in the evening, - only a few minutes' walk from the hotel.
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Election Results
Congratulations to incumbents Isaac Salver and Robert Yaffe who were re-elected and to resident Doris Marano who was newly elected as Council Member to fill the partial term. Salver and Yaffe were elected to a four year term and Marano will serve for one year.
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1-20 of 33 items from 2015 « Prev | Next »
6 hours ago | Variety - Film News | See recent Variety - Film News news »
John Heard, Cloris Leachman, Jacinda Barrett, Dash Mihok and Jessica Collins have been cast in road-trip drama "So B. It," Variety has learned.
Variety reported in May that Alfre Woodard and Talitha Bateman would star in the adaptation of Sarah Weeks' young adult novel.
Stephen Gyllenhaal is directing from a script by Garry Williams, which chronicles the journey of a 12-year-old girl (Bateman) who decides to take a solo cross-country trip and leave the safety of her home life with her mentally challenged mother (Collins) and agoraphobic neighbor, portrayed by Woodard.
Producers are Branded Pictures Entertainment's J. Todd Harris and Orien Richman. Exec producers are Outside the Box Productions' Adam Tenenbaum and Michael Nelson; Marc Marcum co-produces.
Production is set to begin July 13 in Los Angeles.
Heard recently guest starred on "Modern Family" and has a recurring role on "NCIS: Los Angeles." Leachman will be seen next in "This Is Happening" and "Scouts vs. »
- Dave McNary
29 June 2015 12:41 AM, PDT | The Hollywood Interview | See recent The Hollywood Interview news »
Cinema's Hidden Pearls – Part II
By Alex Simon
One of nature's rarest items, a pearl is produced within the soft tissue (specifically the mantle) of a living shelled mollusk. Just like the shell of a clam, a pearl is composed of calcium carbonate in minute crystalline form, which has been deposited in concentric layers. Truly flawless pearls are infrequently produced in nature, and as a result, the pearl has become a metaphor for something rare, fine, admirable and valuable.
Hidden pearls exist in the world of movies, as well: films that, in spite of being brilliantly crafted and executed, never got the audience they deserved beyond a cult following.
Here are a few more of our favorite hidden pearls in the world of film:
1. Massacre at Central High (1976)
Dutch director, and former cameraman for the legendary Russ Meyer, Rene Daalder was hired by producers to direct an exploitation »
- The Hollywood Interview.com
22 May 2015 7:39 AM, PDT | We Got This Covered | See recent We Got This Covered news »
DreamWorks Animation is expanding the voice cast for The Croods 2, its upcoming sequel to the 2013 animated hit, with news that Leslie Mann (This is 40) and Kat Dennings (Thor: The Dark World) will lend their voices to new characters.
Mann will portray the matriarch of an upscale family that winds up in a rivalry with the titular caveman family and their human companion. Dennings, meanwhile, will play the frustrated daughter of that new family, who yearns to hunt but is consistently suppressed by her "civilized" parents.
The key players are all back for this follow-up, including Nicolas Cage as the Croods' patriarch Grug, Catherine Kenner as mother Ugga, feisty daughter Eep (Emma Stone), luggish son Thunk (Clark Duke), ferocious grandma Gran (Cloris Leachman) and Ryan Reynolds as human companion Guy. Kirk De Micco and Chris Sanders are once again writing and directing.
DreamWorks Animation's Bonnie Arnold and Mireille Soria »
- Isaac Feldberg
17 May 2015 6:56 PM, PDT | Cinemaretro.com | See recent CinemaRetro news »
By Todd Garbarini
Cy Howard's 1970 film Lovers and Other Strangers, which stars Bea Arthur, Bonnie Bedelia, Michael Brandon, Anne Jackson, Diane Keaton, and Cloris Leachman, celebrates it's 45th anniversary this year. The Royale Laemmle Theater in Los Angeles will be holding a special one-night-only showing of the 104-minute comedy on Wednesday, May 20, 2015 at 7:30 pm. Scheduled to appear in person are actress Bonnie Bedelia, Cloris Leachman and the Oscar-nominated co-writers Joe Bologna and Renee Taylor for a post-screening Q&A with film critic Stephen Farber.
From the press release:
Lovers And Other Strangers was nominated for three Academy Awards in 1970 and won the Oscar for best original song, "For All We Know." This sharp and poignant comedy examines the relationships of a dozen characters involved in preparing for a family wedding. The superb ensemble cast includes Oscar winners Gig Young, Cloris Leachman, and Diane Keaton (in her first »
- email@example.com (Cinema Retro)
8 May 2015 1:19 AM, PDT | MUBI | See recent MUBI news »
"Yet if you should forget me for a whileAnd afterwards remember, do not grieveFor if the darkness and corruption leaveA vestige of the thoughts that once we hadBetter by far you should forget and smileThan that you should remember and be sad."—Christina Rossetti, Remember (1862)An opening title card from director Thom Andesen's new feature film, The Thoughts That Once We Had, directly identifies the cinematic writings of philosopher Gilles Deleuze as the project's primary subject and inspiration. Deleuze's two volumes on film, Cinema 1: The Movement-Image (1983) and Cinema 2: The Time-Image (1985), are today synonymous with a certain modernist school of thought that, while integrated in academia to such a degree as to be all but understood, remains quite radical. Unquestionably dense and provocatively pedantic, the French empiricist's filmic texts integrate an array of theories and conceptualizations into a fairly delineated taxonomy, and are therefore fairly conducive »
- Jordan Cronk
7 May 2015 1:28 PM, PDT | ScreenDaily | See recent ScreenDaily news »
Highland Film Group (Hfg) has come on to handle sales on animated family adventure Savva and biopic Lamotta: The Bronx Bull.
Maksim Fadeev's animated family adventure Savva features Milla Jovovich and Whoopi Goldberg in the voice cast alongside Sharon Stone, Joe Pesci and Fedor Bondarchuk.
Gregory Poirier wrote the screenplay and Aleksandr Chistyakov produces the tale of a child who teams up with a scratch team of animals to protect a village from a pack of hyenas led by a three-headed monkey.
Martin Guigui's Lamotta: The Bronx Bull recounts the life of legendary boxer Jake Lamotta and stars William Forsythe, Paul Sorvino, Penelope Ann Miller, Tom Sizemore, Cloris Leachman, Joe Mantegna and Natasha Henstridge.
Dahlia Waingort of Sunset Pictures and Scott Reed and Ron Singer of That's Hollywood are producing. Jay and Arti Modi are executive producers.
Hfg's Cannes sales slate includes Steven C Miller's The Feud starring Kellan Lutz; The Trust starring »
- email@example.com (Jeremy Kay)
24 April 2015 12:28 PM, PDT | Alt Film Guide | See recent Alt Film Guide news »
Eli Wallach and Anne Jackson on the Oscars' Red Carpet Eli Wallach and Anne Jackson at the Academy Awards Eli Wallach and wife Anne Jackson are seen above arriving at the 2011 Academy Awards ceremony, held on Sunday, Feb. 27, at the Kodak Theatre in Hollywood. The 95-year-old Wallach had received an Honorary Oscar at the Governors Awards in November 2010. See also: "Doris Day Inexplicably Snubbed by Academy," "Maureen O'Hara Honorary Oscar," "Honorary Oscars: Mary Pickford, Greta Garbo Among Rare Women Recipients," and "Hayao Miyazaki Getting Honorary Oscar." Delayed film debut The Actors Studio-trained Eli Wallach was to have made his film debut in Fred Zinnemann's Academy Award-winning 1953 blockbuster From Here to Eternity. Ultimately, however, Frank Sinatra – then a has-been following a string of box office duds – was cast for a pittance, getting beaten to a pulp by a pre-stardom Ernest Borgnine. For his bloodied efforts, Sinatra went on »
- D. Zhea
22 April 2015 11:47 AM, PDT | WeAreMovieGeeks.com | See recent WeAreMovieGeeks.com news »
Featuring an unprecedented cast of 100 celebrity narrators, the timely documentary Unity will be distributed by SpectiCast in select theatres worldwide beginning August 12.
Written and directed by Shaun Monson (Earthlings), produced by Melissa Danis and Monson, the film explores the interconnectivity of all life on Earth and our responsibility to do better. A production of Monson's Nation Earth, Unity will is expected to premiere on 1000-1200+ screens across the globe. SpectiCast has partnered with Fathom Events for the domestic release on select U.S. screens. Tickets and more information including participating theatre locations and global distribution partners coming soon.
Seven years in the making, Unity explores humanity's impact on the world and our opportunity for transformation. Presented in chapters, Unity takes an in-depth look at what it means to be human, exploring themes of love, tragedy and, ultimately, hope. Coupled with stunning cinematography, Unity is a singular and unforgettable cinematic experience. »
- Melissa Thompson
22 April 2015 9:00 AM, PDT | Variety - Film News | See recent Variety - Film News news »
Shaun Monson's documentary "Unity," featuring 100 celebrity narrators, will be distributed by SpectiCast at 1,000 to 1,200 screens worldwide beginning Aug. 12, Variety has learned exclusively.
The film comes a decade after Monson's documentary "Earthlings," which explored humanity's relationships with other animals. Produced by Melissa Danis and Monson through Nation Earth, "Unity" explores the interconnectivity of all life on Earth and what it means to be human, exploring themes of love, tragedy and hope.
SpectiCast has partnered with Fathom Events for the domestic release on select U.S. screens. The deal was announced Wednesday at CinemaCon.
Celebrities lending their voices to this powerful film include Aaron Paul, Adam Levine, Adrian Grenier, Alison Eastwood, Amanda Seyfried, Amy Smart, Anjelica Huston, Anton Yelchin, Arian Foster, Arlene Martel, Balthazar Getty, Ben Kingsley, Ben Whishaw, Beth Hart, Brandon Boyd, Caroline Goodall, Carrie-Anne Moss, Casey Affleck, Catherine Tate, Claire Forlani, Cloris Leachman, Common, Damien Mander, David Copperfield, »
- Dave McNary
20 April 2015 9:03 PM, PDT | WeAreMovieGeeks.com | See recent WeAreMovieGeeks.com news »
"These guys can not be my groomsmen. It looks like the entire cast of Goonies grew up and became rapists!"
When Jim Batts reviewed The Wedding Ringer here at We Are Movie Geeks, he wrote: "…….First time feature director Jeremy Garelik tries to give the flick a frenzied pace by quickly cutting in for close-ups constantly, which never exhilarates, but merely exhausts the viewer. Every bit of business is hammered home, with little room for characterization. Subtlety? No way! No time! Got to get to the next big "gut-buster"…..(read all of Jim's review Here)
I didn't see The Wedding Ringer when it played theatrically, but after catching up with it on Blu-ray, I'd have to say I liked it a bit better than Jim did, but of course I watched it at home as opposed to a theater full of people who may or may have not been laughing. »
- Tom Stockman
8 April 2015 12:21 PM, PDT | Variety - TV News | See recent Variety - TV News news »
"Girl Meets World" fans don't have to wait too long for the return of Riley, Cory and the rest of the gang.
Disney Channel has set Monday, May 11, for the season-two premiere of "Boy Meets World" spinoff "Girl Meets World," Variety has learned. As an additional treat, one new episode of the show will debut each night May 12-15, totaling five new episodes throughout the week.
The May 15 episode will likely especially intrigue "Boy Meets World" fans, as it marks the return of Cory Matthews' brother Eric. Will Friedle will make his first guest appearance on the show on that episode.
The season premiere, which guest stars Cloris Leachman, follows Riley and Maya as they embark on a new year at John Quincy Adams Middle School and are eager to transfer out of Cory's class. The change, however, doesn't offer the excitement and independence they hoped it would. »
- Alex Stedman
3 March 2015 6:40 PM, PST | Hitfix | See recent Hitfix news »
While romcoms and black comedies may have more sophisticated plots, satires are the films that guarantee us the most laughs. Sometimes you want permission to laugh at movies rather than with them, and satires remind you that familiar movie conventions are strange and sometimes hilarious. We just noticed that one of our all-time favorite Mel Brooks movies has hit Netflix, so without further ado, let's celebrate this nutty genre. "Airplane!": Insanity at 20,000 Feet The bawdy sight gags and astounding one-liners of "Airplane!" run together in a nonstop medley, but I'd like to point out another highpoint of this disaster satire: You can't pick a single Mvp in the ensemble. Every actor is perfectly cast and perfectly effing weird. Robert Hays is stone-eyed and slyly ridiculous. Julie Hagerty is a wide-eyed cuckoo. Robert Stack, Lloyd Bridges, Peter Graves, Leslie Nielsen, Stephen Stucker, Barbara Billingsley, Kareem Abdul-Jabbar, and even Maureen McGovern (as the singing nun, »
- Louis Virtel
27 February 2015 4:27 PM, PST | SoundOnSight | See recent SoundOnSight news »
Adventure Time, Pendleton Ward's kids show turned Cartoon Network cult sensation, is being turned into a big screen, animated movie by Warner Bros., Deadline reported Friday. Mathematical!
Chris McKay and Roy Lee, both of whom were producers on The Lego Movie, and McKay of Cartoon Network's Robot Chicken, will produce the Adventure Time movie.
The show involves a boy named Finn and his best friend Jake the Dog as they protect the citizens of the Land of Ooo from foes of various shapes and sizes, including Evil Guy (voiced by Mark Hamill) and Marceline the Vampire Queen (Cloris Leachman).
No details just yet on a director, plot or when to expect the film, as this is breaking news, but will update as more comes in.
The post What time is it? 'Adventure Time' being made into a movie appeared first on Sound On Sight.
- Brian Welk
27 February 2015 2:08 PM, PST | Variety - TV News | See recent Variety - TV News news »
After six seasons on mega-hit "Lost" and currently starring on CBS' "Hawaii Five-0," now in its fifth season, fan favorite Daniel Dae Kim is stepping behind the camera.
"When I was working on 'Lost,' I shadowed a few directors because it was something that I was interested in, but it wasn't the kind of series where a newcomer could just hop on. It was very complicated," Kim tells Variety of his decision to direct.
"I just watched and learned, and when 'Hawaii Five-0′ came along, once we had a few seasons under our belt, I thought it was the right time to ask. Thankfully, CBS and (exec producer) Peter Lenkov were kind enough to give me a shot," Kim says. "It's a combination of having the desire and getting the opportunity."
The actor-turned-director, who also has multiple pilots in development with his production company 3Ad, tells Variety about »
- Elizabeth Wagmeister
27 February 2015 6:30 AM, PST | TVLine.com | See recent TVLine.com news »
Perhaps Hawaii Five-0's unseen therapist should just wave the white flag and let Steve and Danny agree to disagree?
Related2015 Renewal Scorecard: What's Coming Back? What's Cancelled?
In the above sneak peek from tonight's episode (CBS, 9/8c), Five-0's top cops are subject to another round of therapy, just as they were in the Season 5 premiere. This time around, the topics at hand include someone's "control" issues and the other's tendency to be "overly sensitive."
And on the heels of Danny paying his partner a compliment (of sorts?), there's the matter of Steve response in a bothersome, »
26 February 2015 11:42 PM, PST | SoundOnSight | See recent SoundOnSight news »
Some of the greatest (or at least heavily favored) American television shows got the big screen treatment when they were selected to have their small screen following turn into a cinematic experience. Unfortunately, for every beloved nostalgic television show that translated successfully in movie theaters (The Brady Bunch Movie, Star Trek, Batman, etc.) there are boob tube stinkers that overtake the good crop. Sure, there are middle-of-the-road movie adaptations of television programs that have a mixed bag reception (1997's Leave It To Beaver, 1987's Dragnet, 2012's Dark Shadows, etc.). Nevertheless, it is always the unflattering fare that receive the bulk of the attention (do you register, 1999's The Wild, Wild West ?).
In Boob on the Tube: Top Ten Worst Movie Adaptations of TV Shows we will take a look at the top ten televised offenders that dared to venture into cinema's stratosphere only to end up floating down shamefully »
- Frank Ochieng
23 February 2015 3:00 PM, PST | Variety - Film News | See recent Variety - Film News news »
The night doesn't end when the final Oscar is handed out. In fact, the party is just getting started as stars and execs exit the Dolby Theater, heading to a flurry of post-awards celebrations, including the Governors Ball, the Vanity Fair Party, Elton John's AIDS Foundation party and more. See below for an insider timeline of the festivities.
4:00 p.m. Elton John and David Furnish arrive at John's 23rd annual AIDS Foundation Oscar viewing party. The musician rocks red specs while Furnish shows off golden footwear. The theme of the night is "just straight music," says John.
4:16 p.m. "Modern Family" star Sarah Hyland arrives at Elton John's bash, enjoying a slice of pizza on the white carpet.
4:20 p.m. Musician-producer Nile Rodgers checks in at Elton John's party ready to perform. "Tonight, it means the world to me," he says. "I »
- Variety Staff
23 February 2015 6:07 AM, PST | Hollywonk | See recent Hollywonk news »
They've proven to be among the most popular kids series on Prime Instant Video, and all four of them were recently honored by the Parents' Choice Foundation. Today Amazon announced that it has greenlit second seasons of its hit kids series: Creative Galaxy, Annedroids, Gortimer Gibbon's Life on Normal Street, and recent Annie Award winner Tumble Leaf.
"Tumble Leaf, Creative Galaxy, Annedroids and Gortimer have all experienced a tremendous response from our customers and we're excited to bring them back for another season," said Tara Sorensen, Head of Kids Programming for Amazon Studios. "Working with such remarkably talented and impactful creators in both the preschool and kids six to 11 space, it's exciting to see where the storylines and characters will take us for another season."
Annecy International Festival and Annie award-winning series Tumble Leaf was created by Drew Hodges (Saturday Night Live, Community) and executive produced »
22 February 2015 12:55 AM, PST | Flickeringmyth | See recent Flickeringmyth news »
The Wedding Ringer, 2015.
Directed by Jeremy Garelick.
Starring Kevin Hart, Josh Gad, Kaley Cuoco-Sweeting, Olivia Thirlby, Ken Howard, Alan Ritchson, Dan Gill, Jorge Garcia, and Cloris Leachman.
Two weeks shy of his wedding, a socially awkward guy enters into a charade by hiring the owner of a company that provides best men for grooms in need.
In a week which saw long-running NBC show Saturday Night Live celebrate its 40th anniversary as the staple of American comedy, it seems apt that a comedy starring Kevin Hart, who auditioned for the show a few years back similarly to Jim Carrey and Zach Galifianakis, is released. Like Ride Along and Think Like A Man, The Wedding Ringer relies heavily of Hart's usual charm and comedic talents to carry a somewhat mediocre concept through to box office glory, but with a less than stellar box office take in the Us thus far (the No. »
- Scott J. Davis
20 February 2015 12:58 PM, PST | OnTheFlix | See recent OnTheFlix news »
Recently,CBS released the new,official synopsis/spoilers for their upcoming "Hawaii Five O" episode 17 of season 5. The episode is called, "Kuka'awale (Stakeout)," and it turns out that we're going to see some interesting stuff go down when McGarrett and Danny hit up an intense stakeout scene, and try to repair their relationship simultaneously, and more. In the new, 17th episode press release: McGarrett and Danny are going to work on their relationship while they stakeout a woman's apartment after she escapes following a diamond robbery. Press release number 2: McGarrett and Danny will work on their relationship while they stakeout a woman's apartment after she escapes following a diamond robbery. Series star ,Daniel Dae Kim, makes his directorial debut. Max Weinberg, Emmy Award winner Cloris Leachman, Charlie Saxton, Jon Lovitz and Jessica Lowndes guest star. Other guest stars feature: Cloris Leachman (Ruth Tennenbaum), Jon Lovitz (Barry Burns), Charlie Saxton »
- Derek
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7 low-cost videoconferencing services: Which is best for your meeting?
Remote colleagues and friends are the norm today. We look at 7 online services that help you keep in touch.
These days, any computer with a webcam -- and most current tablets and smartphones -- can be a front-end to services that offer low-cost or free videoconferencing functionality. Services such as Skype and Google+ are offering alternatives to conferencing solutions that used to cost companies thousands of dollars.
In fact, many of these services have moved away from being formally installed apps, and can be invoked from most any kind of hardware client or OS platform through its browser. Some use Flash to run entirely in-browser; some deliver a binary executable on-demand through the browser, which runs as-is without needing to be installed; some still use a local client.
Most of the systems profiled here have many essential features in common, even at their most basic level, such as text chat (as well as voice/video chat) or the ability to share documents, applications or the entire desktop among conference attendees.
Features available in the more advanced tiers include the ability to record conferences, support for large numbers of people (that is, more than five or ten) and high-definition video. In all cases, there's a moderator who has control over the conference room behavior (such as who has the floor or who can show his or her desktop to the rest of the members) using a central console.
Prices in these formerly expensive services have changed over the last couple of years. Entry-level pricing now starts at anywhere from $8 to $40 a month. Many companies provide trial periods or free usage tiers (albeit with some features missing).
I looked at seven major offerings, ranging from free adjuncts to popular social-networking systems to products with enterprise-level tiers; some needing a local client, some not.
To try them out, I held test videoconferences, using three participants on different platforms -- both Windows and OS X, whenever possible. We looked at how the apps were deployed and how they were performed, and also for the presence of auxiliary features, such as the logging of discussions or tools for moderators and presenters.
While they may not be appropriate for some high-end uses, most of these services can offer solid, basic videoconferencing that can allow you to keep in touch with your remote colleagues and friends -- and perhaps even get some work done.
(Story continues on next page.)
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Young Scooter »
Young Scooter x Zaytoven – Juggathon (Mixtape)
One of Atlanta's biggest street rappers and super producer Zaytoven have teamed up for a brand new mixtape. Black Migo Gang's own Young Scooter and Zaytoven have linked for this new project entitled 'Juggathon'.Read More »
Young Scooter – Dirty Game (Prod. By Zaytoven)
The rap game and the trap game go hand in hand as far as underhanded deals and betrayal. With his latest single, Scooter expresses his frustrations on top of the production by Zaytoven. HisRead More »
Gucci Mane – King Gucci (Mixtape)
As he remains incarcerated, Gucci Mane brings to us a brand new mixtape entitled, King Gucci. Coming in with 10 tracks, La Flare brings us contributions from Young Scooter, Fetty Wap, Riff Raff, MigosRead More »
Young Scooter – Pots & Stoves Ft. Boosie Badazz (Video)
Scooter releases his latest visual effort off his "Jug Season" out now. What does a street pharmacist need more than pots and a stove? Young Scooter and Boosie connect to describe exactly what it's allRead More »
Young Scooter – Oooooh Ft. Future
Originally Future's track which appeared on the Zaytoven-produced Beast Mode EP, Young Scooter takes the leading role on an updated version of the track featuring creator of the booming record, of course. The recordRead More »
Young Scooter – Jug Season (Video)
Count up! The Freeband Gang member is back with some new visuals to let you know what time of year it is. Scooter takes us to the trap once again with the video forRead More »
Digital Trapstars – Screens On Lock 2 (Mixtape)
Digital Trapstars and Trapstar Clothing London team up to deliver Screens On Lock 2. The 11-track mixtape features Too Short, Mistah Fab, 808 Mafia, Waka Flocka, Future, Migos, Rich The Kid, Young Scooter, KevinRead More »
Young Scooter – B.I.G
Young Scooter pays homage to the late Notorious B.I.G. on his latest record. The Stackboy Twaun-produced tribute track opens with a clip of a Biggie interview before Scooter makes plenty of references to theRead More »


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Joel Purra
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(I'm from Sweden. Current location may change, as I'm moving/traveling quite often.)
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