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Tom Paris - awesome or vastly underused?
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June 29 2012, 08:14 AM
Fleet Admiral
Location: Nyotaimori
Re: Tom Paris - awesome or vastly underused?
The crew of the
Sea Shepard
rogues. Ideology driven rogues like Paris managed to pony up into for 30 Days. His ONE dalliance in roguedom.
Do you know how they wash their clothes on the Sea Shepherd when they are on their long, cold, fishy voyages saving stuff? They put all their clothes in a net and drag them behind the boat until they are cleaner than they were before they went into the net. So they are a lot more rogueish in scent then Tom Paris and his replicated uniforms. Do you still smell of salt after leaving a Horatio Hornblower holonovel?
"Damnit Spock. God damnit!" Kirk ST:V
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Obituary & Guest Book Preview for William Doyle Pittcock
William Doyle Pittcock Obituary
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: William Doyle Pittcock Aspermont, TX William Doyle Pittcock was born January, 16, 1926 at home on the forks of the Brazos near Kiowa Peak. He...
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Corto Maltes Ocean Front Luxury Vacation Condos
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Run, run, run!!
Our first day with the full family, Huesos y Luisa arrived last night.
After a good slow start (vacation standards) we decided to go again to the Sr. Frogs beach club, the beach is beautiful there and the sea is just a huge swimming pool.
We spent most of the day there sipping clamatos, micheladas, tanning, swimming or just …
End of SCUBA Diving Certification!
Girls did not like it but we had an early rise to go SCUBA Diving, the day started at 8 and we spent all morning diving. We went to a place called "Tortugas", it is a drift dive, the current moves you and sometimes it is hard to stay in a place when you see something interesting but it was great.
I used the GoPro for the first time, we saw …
Fly from Chicago to Cancun & transfer to Condo
... bulkhead.
Flight went well. Delilah was well behaved.
Transfer to Condo went smoothly (~30 minutes)
We were greeted by xxxxx, our host. He made sure were properly settled and offered help several times during the week.
From the Jungle to the Coast
... manicured gardens. Its a great alternative to the Mayaland.
We then continue our journey to the coast with a lunch stop at Selva Maya. It's a really nice buffet with lots of food options from western to Mexican cuisine. This was a cattle hacienda previously and can be used for weddings, dinners and events. Eventually this will be a hotel as well.
We drive through Valladolid which means White Eagle. This was once the capital of the Yucutan prior to ...
The honeymoon
... going out. I have been steadily drinking cervezas and mojitos all day but it's not really the same when you're on your own! Megan's been struggling with what we thought was a cold since before we left and last night got hit by a bout of travellers' tummy, which hit her for six, so she went to the doctor to see what was up and has a throat infection. She got some antibiotics and feels better already, so hopefully she's all set ...


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Originally written on Redskins Insider | Last updated 12/28/11
ASHBURN, VA - JULY 29: Quarterback Rex Grossman of the Washington Redskins throws a pass during drills on the first day of training camp July 29, 2010 in Ashburn, Virginia. (Photo by Win McNamee/Getty Images)
As he enters the final game of the season against the Philadelphia Eagles, Redskins quarterback Rex Grossman said that his confidence is "at an all-time high." Grossman has thrown 15 touchdown passes and 2,895 yards – both the second-highest totals for his career -- and has completed 58.8 of his passes (a career best). But he also has 19 interceptions – he has thrown at least one in 11 consecutive games -- and five fumbles while the Redskins went 5-7 in the 12 games he has started. Read full article >>
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mass flow controllers Equipment in Somalia
Category: Air & Climate ×
Subcategory: Air Monitoring ×
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Location: Africa ×
Location: Somalia ×
Model PRO902C Modular - External Low Flow Dilution Probeby Thermo Scientific - Air Quality Instruments based in Franklin, MASSACHUSETTS (USA)
PRO902C Probe handles the toughest environments while offering significant advantages over typical in-stack dilution probes.The dilution extractive technology in combination with the thermo-electric cooler provides accurate and concise readings available in both terms of concentration and mass-emission rates. aturing an O2 fuel cell for oxygen ...
TAPI - Model 701 - Zero Air Systemby Teledyne Advanced Pollution Instrumentation, Inc. (TAPI) based in San Diego, CALIFORNIA (USA)
The Model 701 is an excellent source of clean, dry air for dilution calibrators. It also may be used as a source of purge air for permeation tube ovens or burner air for FID analyzers.
TAPI - Model T700H - Source Monitoring Dilution Calibratorby Teledyne Advanced Pollution Instrumentation, Inc. (TAPI) based in San Diego, CALIFORNIA (USA)
The Model T700H is a microprocessor controlled dilution system for calibration of continuous emissions monitoring gas analyzers. It enables significantly reduced cylinder use and cost while improving on-site flexibility for gas concentrations and converter efficiency checks. The instrument is designed to meet or exceed the performance requirements ...
Cyro Concentrator AutoSamplerby Wasson-ECE Instrumentation based in Fort Collins, COLORADO (USA)
Wasson-ECE Instrumentation has developed a new cryo-concentrator for your environmental analysis needs. The system includes a built-in 16 position autosampler for sampling from SUMMA canisters and Tedlar bags. The samples are collected on a proprietary trap that is cooled by liquid nitrogen or liquid carbon dioxide. The system is ideal for TO14/15 ...
MCZ - Model MK5 / MK10 - Calibration Systemby Umwelttechnik MCZ GmbH based in Bad Nauheim, GERMANY
The calibration system MK5/MK10 is equipped with standard modules for the different methods of generating span gas based on the specific application. The generated span gas is provided depressurized for output. The MK5 series can be equipped with max. 5, the MK10 series with max. 10 modules. Used to calibrate gas analyzers in labs, service ...
Environics - Model Series 2020 CEMCS - Continuous Emissions Monitoring Calibration Systemby Environics, Inc. based in Tolland, CONNECTICUT (USA)
The Environics Series 2020 Continuous Emissions Monitoring Calibration System (CEMCS) automatically generates precise gas standards for rapid multi-point and multi-scale calibration of Continuous Emissions Mon
INNOVA - Model 1313 - Photoacoustic Fermentation Monitorby LumaSense Technologies GmbH based in Frankfurt, GERMANY
LumaSense's Fermentation Monitor INNOVA 1313 simultaneously measures the concentrations of Oxygen and Carbon Dioxide in the exhaust gas from fermenters, providing data for calculation of the Respiratory Quotient (RQ). At the same time, the concentration of Hydrocarbons produced (for example Ethanol) can be measured. It can be integrated into ...
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The dichotomous air sampler is a dual-filter air sampler for thesimultaneous collection of the fine PM2.5 and the coarse PM10-2.5particles contained within PM10. Split flow configuration of the virtualimpactor allows a PM10 aerosol to be separated into fine particles andcoarse particles for subsequent collection onto 2 separate PTFE ...
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Model Red-y smart Series - Mass Flow Meters and Controllersby Vögtlin Instruments AG based in Aesch BL, SWITZERLAND
Reliable technology and standardized interfaces make the red-y smart series thermal mass flow meters and controllers particularly suitable for measurement and control in gas delivery systems and plant engineering applications.


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Craig Clough, Staff writer
What's wrong with Houston airport security? From stolen property to questionable pat downs, Channel 2 Investigates' Jace Larson sifts through hundreds of local TSA complaints to uncover the most reported problems, tonight on Channel 2 News at 10...
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Hurray, summer is finally here. However, you need to watch out for these all-too-common health hazards that accompany the nice weather.


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Low-Cost Clothing Crafts
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Internet-Inspired Painted Pumps
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If you need an excuse to turn off the TV, consider some fashion crafts for teens. Internet-Inspired Painted Pumps can be created using an old pair of heels and some paint. Add fun phrases like "LOL" and "FYI" - these shoes will sure speak for themselves.
- High heels (color of your choice – this will be the color of the letters)
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- Craft foam letters (sticky) – various sizes and lettering
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Remove the paper backing from each letter and press onto shoe. Be sure that all edges of the letters are pressed down firmly so that you get a crisp image.
Use tape to protect the inside surfaces of the shoe from overspray. Cover the entire inside with overlapping strips of tape.
In a well-ventilated area (preferably outdoors), spray the entire outside of shoes with spray paint. Spray on one light coat. Let dry and spray on another light coat. Let dry completely.
Remove craft foam letters to reveal #hashtag words.
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LPG tanker Navigator Aries (23,333 dwt, built 2008), and containership Leo Perdana (33,423 dwt, built 2007) collided yesterday in waters off Gresik, nearby the Port of Tunjung Perak in Surabaya,
As the demand for mega vessels has increased, Hyundai Heavy Industries Co. expects mega- sized container ships to lead global orders until early next year as shipping
Canada slaps sanctions on Gazprom, other Russia energy firms
Canada is imposing economic sanctions against Russian energy firms such as natural gas producer
Gujarat Pipavav Port (APM Terminals Pipavav) has resumed operations following improvement in weather conditions.
Last week, the port operations were suspended
Port of Savannah set records for both container volumes and total tonnage in May, with the highest tonnage ever recorded in a single month.
The Port of Savannah has handled more than 338,
Britons faced chaos in Calais last night after striking French sailors blocked the port for the second time in a week. Ferry services between Dover and Calais


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U.S. Fans Abound For WWC Final LeBron Praised For Role In Apatow's "Trainwreck" MLS Eyeing St. Paul For Expansion Club Angels Bad PR Continues With Dipoto Exit NBA Free Agency Begins With Money Flying Expectations High For NASCAR On NBC NBC Lands New Advertisers For Race Coverage Going Off The Grid Steelers Exploring '23 Super Bowl Bid GT To Benefit Financially From Ireland Game
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SBD/January 26, 2011/Classified Advertisements
SBJ In-Depth: Information Technology in Sports
Published January 26, 2011
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Store simple data without a database using web storage solutions like XML, JSON, YAML, and HTML5.
Take advantage of the HTML5 geolocation feature by using the recently released Google Store Locator Utility Library, and include directions and feature filtering in your web apps.
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Facebook was created on Feb. 4, 2004. Facebook now has over 1 billion people using it every month and is constantly in the headlines. Take a look at how it all began.
Univision CEO Randy Falco says Donald Trump is not telling the truth when he claims that "Univision apologized."
In an internal memo on Monday, Falco defended the Spanish-language broadcaster's decision to break off its ties to Trump.
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Gossip Girl
Ed Westwick Pops His Collar at the 2012 Style Award (PHOTOS)
Big news, Upper East Siders! Ed Westwick was dubbed "One to Watch" at the 9th Annual Style Awards, and it certainly appears that all eyes were on him as he arrived at the event. Check out these pics as he made his way in. From smoulder, to sexy, to full-on Blue Steel — Ed Westwick knows how to make a camera love him. Oh, and us, too!
Want more Gossip Girl goodness? Like us on Facebook or follow us on Twitter! You know you love us. XOXO


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- Film, Media & Entertainment
- Hammersmith Road, Kensington, London, Gt Lon, W14 8UX
Film screening: 'Unseen Colombia'
UCL - Institute of the Americas
Friday, 22 November 2013 from 17:00 to 19:00 (GMT)
President Santos inaugurates an international mega-project with champagne – while, just metres away, children who have been displaced by it die. General Reyes boasts that a guerrilla leader has been executed little knowing that, a few hours later, he will be forced to admit that it was the leader of an indigenous community who was put to death. A judge investigating members of the military for the rape and murder of children, dies mysteriously. Workers at a banana plantation have to risk their lives to assert their human rights. This brave and hard-hitting documentary attempts to challenge the impunity of these outrages against the people of Colombia. 'Unseen Colombia' (Colombia/Spain, 2012; 63 mins.) is directed by Unai Aranzad.
UCL-Institute of the Americas proudly hosts this film, in collaboration with the London Latin American Film Festival 2013. Attendance is free of charge but registration is required, due to limited seating capacity.
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86329 is utilized for post office box purposes only in approximate location displayed above. No relevant statistics are associated with this ZIP Code.
|For Sale: 15
|New: 1
|Recently Sold: 9
|Reduced: 9
|Average Home Price
|Average Sold Price
|Property Records: 302
|Foreclosed: N/A
The average home price in 86329 is $267,104, which is 216.1% higher than the average sold price in 86329 ($84,502) . The average home price per square foot in 86329 is $175 and about 3% of all homes in 86329 sold in the last 6 months. For 86329 home values, real estate prices, and city market trends, research the 302 property records or search our 9 recently sold or 15 homes for sale listings. The listings and properties in 86329 are only a part of the 2,120,208 properties and 42,640 homes for sale in Arizona. Because of this, the average home price and average home value of 86329 also influence the average home price $214,914 and average sale price $244,717 of Arizona. Listing counts, 86329 home prices and home values in 86329 are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.


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National Park Service Glen Echo Park U.S. Department of the Interior A Walking Tour Glen Echo Park is administered by the George Washington Memorial Parkway In 1890, Discovery Creek Located on Path into Visitor Center and 1 Bridge over Minnehaha Creek brothers 2 Children's the park 4 the first Popcorn Gallery Edward Museum, a floor of and Edwin Living Classrooms the Arcade Baltzley created the Glen Echo on program, offers children's programs Building, the Visitor Center features a the Potomac real estate development that continue the Chautauqua ideal timeline of the park's history as well hoping to lure Washingtonians of teaching about the natural world. as documentaries and historic videos to live in the beauty and serenity Discovery Creek Children's Museum of the park. The National Park Service of this new suburban community. is located in a building that once also offers free guided walking Photo by Candace Clifford Glen Echo became the site of the housed the electric supply for the tours of the park. For tour times and 53rd Chautauqua Assembly, offering amusement park. reservations for groups of 10 people Photo by Bruce Douglas summer courses in the liberal and or more, please call 301-320-1400. practical arts. The crown jewel of the Chautauqua was an 8,000- The Popcorn Gallery seat amphitheater that sat atop Minnehaha Creek and used the water flow to power the speaker Clara Barton National Historic Site Trolley and The neon system. During the amusement park 5 Entrance sign marks era, the amphitheater became the The Baltzley brothers donated a the original The style of the entrance changed over the years, as did Midway, home to many rides and house and land to Clara Barton, the entrance to Photo by National Park Service the style of the trolleys. entertainments. founder of the American Red Cross, the park. During the Chautauqua in an effort to bring prestige to their era, horse-drawn carriages pulled up Glen Echo community. Built in 1891, to the entrance. Beginning in 1897, it was first used as a warehouse for trolleys rode the rails to the park disaster relief supplies. In 1897, Miss A park ranger explains the timeline from Georgetown and continued Barton made it her home and the to visiting students. on to the Cabin John Bridge, Photo by Meredith Forster headquarters for the American Red approximately one mile west of the Cross. Thinking the house looked The Popcorn Gallery, which served park. Because the trolley company too somber, Miss Barton changed as a refreshment stand during the owned the park, it promoted the original granite façade of the amusement park era, opened in the park to increase both park Trolley passes often promoted the park. residence to an elegant Victorian Discovery Creek Children's Museum teaches 2006 as an exhibition space operated attendance and trolley An etching shows the original amphitheater, which wooden façade, retaining only the children about the natural world. by the Glen Echo Park Partnership ridership. Trolley service became the Midway during the amusement park granite corners. The National Park for Arts and Culture. Throughout continued until January era. The Midway was destroyed in 1956 when it Service offers free daily guided tours the year, the Partnership organizes 1960. became too expensive to maintain. The stone Caretaker's Cottage dates exhibitions that feature the work of of the site, except on Thanksgiving, The trestle that supported the Glen from the Chautauqua era and was local and regional artists. Christmas, and New Year's Day. To The entrance to the Echo trolley – the primary mode of originally a two-story structure. make reservations for groups of 10 or park was reinvented public transportation that carried Today, the remaining first level of the more, please call 301-320-1410. many times before visitors to the park during the building houses the park's resident Photos by National Park Service settling on the Art Deco Chautauqua and early amusement glassblowing studio. style in 1940. Installed park years – is visible from the bridge in 2003, the current as you look toward MacArthur neon "Glen Echo Park" Boulevard. sign is a replica of the 1940 sign. The Popcorn Gallery showcases the work of local and regional artists. Horse-drawn carriages and trolley cars at the park's entrance 6 Chautauqua Tower, Yellow Barn, and Candy Corner It also provides space for two additional artist studios. The building was rebuilt in 2007. The stone tower, once an entrance gate and bell tower, is the only Photo by National Park Service remaining intact building from the Chautauqua era. During the Photo by Sharon McClintic amusement park era, it housed the The Caretaker's Cottage once had two stories. park superintendent and security Clara Barton on her front lawn offices for the park. Renovated in The Minnehaha Creek and trolley trestle 2008, the tower now houses two artist studios. The Yellow Barn The Yellow Barn was built in 1914 and served as the amusement park's In 1972, six woodworking and repair shop. Since 3 cupcake-shaped Yurt Village 1994 it has housed the park's resident sod-roofed yurts painting and drawing program. (an experimental housing design based on traditional Mongolian dwelling huts) were Candy Corner in the 1950s erected in the park on the site of the demolished roller coaster to offer resident artists much-needed studio The Candy Corner sold sweets space. In 1975, the park's fledgling – cotton candy, candied apples, lollipops, and ice cream – during Photo by Deborah Dubois Photo by Jonathan Charry pottery classes moved out of the old the amusement park era. Rebuilt in Photo by Deborah Lange amusement park cafeteria and into the yurts, establishing a permanent 2007, this space has been used for home for Glen Echo Pottery. The yurts classroom space and children's art also provide space for other resident The stone tower in the 1920s programs. The yurts provide studio space. A pottery artist creates a bowl studio artists. at Glen Echo Pottery. Yellow Barn artists paint the carousel horses. EXPERIENCE YOUR AMERICA™ About Glen Echo Park This brochure was generously written and designed by Deborah Lange. Historic photographs were Glen Echo Park is a national park like no other. In 1891, it was home generously provided by Richard Cook, Harold Silver, Frederick W. Schneider III, and George Kiefer. Banner photographs (left to right): National Park Service, Meryl Silver, Daniel Schreiber, Bruce Douglas to a Chautauqua Assembly, an educational summer camp where people could study the liberal arts and sciences. From the late 1890s The Glen Echo Park Partnership for Arts and Culture, Inc. is funded by an operating grant from the Maryland State Arts Council, an agency dedicated to cultivating a vibrant cultural community until 1968, Glen Echo Park was a popular amusement park. During where the arts thrive, and also by funding from the Montgomery County government and the Arts the 1960s, the private owners of the park tried unsuccessfully to and Humanities Council of Montgomery County. In addition, individual, foundation, and corporate redevelop the site as high-rise apartment buildings. The federal donors generously support the Partnership. All programs are produced in cooperation with the government acquired Glen Echo Park in 1970 and the National Park National Park Service and Montgomery County, Maryland. Service (NPS) reopened it to the public in 1971 as an arts park. In This publication has been financed in part by the Montgomery County Historic Preservation June 2002, the NPS transferred several major management functions Commission Grant Fund which is administered by the HPC and the Montgomery County Planning Board of the M-NCPPC, and with State Funds from the Maryland Heritage Area Authority, an of the park to Montgomery County, Maryland. The county in instrumentality of the State of Maryland. However, the contents and opinions do not necessarily turn formed the Glen Echo Park Partnership for Arts and Culture, reflect the views or policies of the Maryland Heritage Area Authority. Also, this publication is made a nonprofit organization, to manage the facilities and the arts, possible in part by funding from the Heritage Tourism Alliance of Montgomery County. cultural, and educational programs at the park. Recognizing that The National Park Service preserves and protects over 390 treasures - natural, cultural, and Glen Echo Park is a treasure for the entire region, Montgomery recreational sites across the country. Experience Your America! County, the State of Maryland, and the federal government committed over $22 million toward renovating the park's facilities. This multi-year rehabilitation was completed in 2009. Today, more than 450,000 people visit the park annually for festivals, exhibitions, social dances, children's theater, art classes, and ranger-led tours. Glen Echo Park A Walking Tour In the past, Constructed in stages, the Coaster over time until the ride covered the The Bumper 7 various roller Coaster Dips Dips started out with seven dips. area from the Chautauqua Tower to 11 Bumper Car Pavilion Car Pavilion coasters occupied New dips and climbs were added the Minnehaha Creek. was originally what is now the called the grassy area near the yurts and the Skooter when it came to the park park flagpole. The largest of them, in 1923. In 1995, the National Park the Coaster Dips, arrived in 1921. Service organized a major volunteer effort that included constructing Photo by Peter Somerville a foundation wall, replacing floorboards, and stabilizing the structure. The Bumper Car Pavilion Riders get ready to bump and is now a popular venue for dances, concerts, private rentals, classes, and Contra dancers in the Bumper Car Pavilion dodge in competitive fun. special events. The Gravity Railway, built in 1912, was later replaced by the Coaster Dips. The Cuddle Up, Cuddle Up and 12 a teacup ride, Hall of Mirrors arrived in 1946 and continued to be popular until the park closed in 1968. Today, the Cuddle Up is used for art classes and camp programs, and the stage is ideal for performances. Built in 1964, the Hall of Mirrors is now used for dance and movement classes. The Alpine Hi-Ride arrived in 1966 and Riders on the offered spectacular views of the park. A 1960s aerial view showing the Coaster Dips, Cuddle Up The Coaster Dips grew a bit each year until it Chautauqua Tower, and Arcade reached the height shown at the right. Installed at Glen Dentzel Carousel Company of Formerly the site of Dentzel 8 Carousel Echo Park in 1921, Philadelphia, Pennsylvania. 13 the Chautauqua Hotel Arcade the carousel was In 1960, the carousel was the and Administration made by the focal point of a civil rights Building, the Art Deco sit-in demonstration against Arcade was built in stages starting in segregation at the park. Yielding 1940 to house games, such as a shooting to local pressure, the park's gallery, skeeball, and other attractions. private owners opened its gates The main level of the Arcade Building to all races in 1961. now provides space for several long- Photo by Deborah Lange standing resident arts organizations, In 1970, the carousel was slated including Adventure Theatre and to be moved to California. The the Puppet Co., as well as the park's local community, however, photography, fused glass, and music raised the funds to purchase the The carousel continues to delight programs. Renovated and reopened in carousel and donated it to the children of all ages. 2004, the upper levels of the Arcade National Park Service, thereby Building house the offices of the saving it for present and future A 20-year effort to restore the Glen Echo Park Partnership and many generations. The Glen Echo Park carousel was completed in 2003. The A confrontation at the park ultimately led to the classrooms. The shooting gallery in the original arcade park's decision to embrace all people. Partnership currently operates carousel is listed on the National and maintains the carousel. Register of Historic Places. Before the Art Deco Arcade was built, The Crystal the amusement park's original 9 Crystal Pool Pool opened in arcade housed 1931. It was an games and other Olympic-sized attractions. pool that accommodated up to 3,000 swimmers. In addition, it featured a quarter-acre sandy beach. The pool was filled in after the amusement park closed. In the 1980s, the area The Moon Ride, pinball machines, became the site of a children's The amusement park used stylized and other posters to promote its attractions. playground. In 2000, the local games delighted It also held drawings and contests. community installed new equipment, amusement park which it funded through a grassroots patrons. campaign. In 2009, the National Park Service updated the playground with new landscaping and seating. A dip in the pool followed by relaxation on the sandy beach During the 1970s, the pool's locker was a perfect way for land-bound rooms housed a sculpture program Washingtonians to spend a hot and a foundry. Today, only the Art summer day. Deco façade remains. It was rebuilt The Nutcracker, presented annually in 2009. by the Puppet Co., is a holiday The Comfort Station, or park favorite. Picture from the restrooms, was originally the site puppet co to go here. of a souvenir and game stand. The Adventure Theatre, National Park Service offices are now the park's longest- on the lower level. standing resident Photo by Bruce Douglas organization, offers Photo by Christopher Piper The amusement park's First Aid live performances for Station, now called the Crystal Pool The souvenir and game stand children of all ages. Studio, houses the park's resident across from the carousel Night-time swimming was a special treat. children's art program. Festivals installed the playground. To volunteer, Rentals In 1933, the halls on the East Coast. The The Spanish Ballroom, Bumper Glen Echo Park is home to many music, please call the National Park Service Photo by Tobias Karlsson Spanish 10 Ballroom mission-style Glen Echo Park Partnership dance, and family festivals, including at 301-320-1400 or the Glen Echo Park Car Pavilion, Cuddle Up, Arcade Spanish Ballroom co-produces a year-round classrooms, and other spaces at the the Washington Folk Festival. Partnership at 301-634-2222. was built over schedule of events in the park are available for private rentals. the 7,500-square-foot floor of the ballroom, including social For more information about facility previous Crystal Ballroom. Many dances in various styles – rentals, please call 301-634-2233. big name bands – such as Tommy such as contra, swing, waltz, Dorsey, Artie Shaw, Lawrence Welk, tango, and salsa – as well as Photo by Deborah Lange Bill Haley and the Comets, and classes and special events. others – played to capacity crowds of up to 1,800 dancers. In the 1960s, Photo by Deborah Lange the ballroom was used briefly as a Jungleland ride. In the 1970s, the National Park Service restored it to ballroom use. Musicians gather for one of the Today, swing dancing is popular many festivals in the park. In 2003, the ballroom was in the ballroom. Volunteers completely renovated, including The Spanish Ballroom is one of several venues that The park's active volunteer program placing windows in the open can be rented for special events. has resulted in many benefits. Photo by Deborah Lange arches and restoring the tile foyer, Volunteers saved the Bumper Art Deco mirrors and lights, and For National Park Service information, Car Pavilion from demolition by painted columns. Today, the Spanish visit nps.gov/glec. stabilizing the structure. They Ballroom is one of the best dance For program information or to make a In the 1920s, A. L. Oehmann's Glen Echo Dance Orchestra repaired the floor of the Spanish Volunteers raise the last column included a banjo player as rag tunes were popular. Ballroom, planted flowers, and of the Bumper Car Pavilion. contribution, visit glenechopark.org. EXPERIENCE YOUR AMERICA™
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Publications (20)147.84 Total impact
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Article: Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity[Show abstract] [Hide abstract]
ABSTRACT: Key points Endogenous soluble VEGF receptor-3 is expressed by cornea that binds and sequesters VEGF-C and it is critical for corneal alymphaticitySoluble VEGFR-3 over-expression enhances murine corneal graft transplant survival 5-fold by blocking lymphangiogenesis and hemangiogenesis.Blood 03/2013; 121(20). DOI:10.1182/blood-2012-08-453043 · 10.43 Impact Factor
Article: Targeted Intraceptor Nanoparticle Therapy Reduces Angiogenesis and Fibrosis in Primate and Murine Macular Degeneration[Show abstract] [Hide abstract]
ABSTRACT: Monthly intraocular injections are widely used to deliver protein-based drugs that cannot cross the blood-retina barrier for the treatment of leading blinding diseases such as age-related macular degeneration (AMD). This invasive treatment carries significant risks, including bleeding, pain, infection, and retinal detachment. Further, current therapies are associated with a rate of retinal fibrosis and geographic atrophy significantly higher than that which occurs in the described natural history of AMD. A novel therapeutic strategy which improves outcomes in a less invasive manner, reduces risk, and provides long-term inhibition of angiogenesis and fibrosis is a felt medical need. Here we show that a single intravenous injection of targeted, biodegradable nanoparticles delivering a recombinant Flt23k intraceptor plasmid homes to neovascular lesions in the retina and regresses CNV in primate and murine AMD models. Moreover, this treatment suppressed subretinal fibrosis, which is currently not addressed by clinical therapies. Murine vision, as tested by OptoMotry©, significantly improved with nearly 40% restoration of visual loss induced by CNV. We found no evidence of ocular or systemic toxicity from nanoparticle treatment. These findings offer a nanoparticle-based platform for targeted, vitreous-sparing, extended-release, nonviral gene therapy.ACS Nano 03/2013; 7(4). DOI:10.1021/nn305958y · 12.03 Impact Factor
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ABSTRACT: Optimal phototransduction requires separation of the avascular photoreceptor layer from the adjacent vascularized inner retina and choroid. Breakdown of peri-photoreceptor vascular demarcation leads to retinal angiomatous proliferation or choroidal neovascularization, two variants of vascular invasion of the photoreceptor layer in age-related macular degeneration (AMD), the leading cause of irreversible blindness in industrialized nations. Here we show that sFLT-1, an endogenous inhibitor of vascular endothelial growth factor A (VEGF-A), is synthesized by photoreceptors and retinal pigment epithelium (RPE), and is decreased in human AMD. Suppression of sFLT-1 by antibodies, adeno-associated virus-mediated RNA interference, or Cre/lox-mediated gene ablation either in the photoreceptor layer or RPE frees VEGF-A and abolishes photoreceptor avascularity. These findings help explain the vascular zoning of the retina, which is critical for vision, and advance two transgenic murine models of AMD with spontaneous vascular invasion early in life. DOI:http://dx.doi.org/10.7554/eLife.00324.001.eLife Sciences 01/2013; 2:e00324. DOI:10.7554/eLife.00324 · 8.52 Impact Factor
Article: Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR)[Show abstract] [Hide abstract]
ABSTRACT: The KDR gene, which participates in angiogenesis and lymphangiogenesis, produces two functionally distinct protein products, membrane-bound KDR (mbKDR) and its isoform, soluble KDR (sKDR). Since sKDR does not have a tyrosine kinase domain and does not dimerize, it is principally an antagonist of lymphangiogenesis by sequestering VEGF-C. Alternative polyadenylation of exon 30 or intron 13 leads to the production of mbKDR or sKDR, respectively, yet the regulatory mechanisms are unknown. Here we show that an antisense morpholino oligomer directed against the exon 13-intron 13 junction increases sKDR (suppressing lymphangiogenesis) and decreases mbKDR (inhibiting hemangiogenesis). The latent polyadenylation site in intron 13 of KDR is activated by blocking the upstream 5' splicing site with an antisense morpholino oligomer. Intravitreal morpholino injection suppressed laser choroidal neovascularization while increasing sKDR. In the mouse cornea, subconjunctival injection of the morpholino-inhibited corneal angiogenesis and lymphangiogenesis, and suppressed graft rejection after transplantation. Thus, this morpholino can be used for concurrent suppression of hemangiogenesis and lymphangiogenesis. This study offers new insight into the mechanisms and potential therapeutic modulation of alternative polyadenylation.-Uehara, H., Cho, Y. K., Simonis, J., Cahoon, J., Archer, B., Luo, L., Das, S. K., Singh, N., Ambati, J., Ambati, B. K. Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR).The FASEB Journal 09/2012; 27(1). DOI:10.1096/fj.12-213835 · 5.48 Impact Factor
Conference Paper: A novel approach for treatment of neovascularization by Flt2-3k integration into the genomeARVO; 05/2012
Article: Nanoparticle-Mediated Delivery of shRNA.VEGF-A Plasmids Regresses Corneal Neovascularization[Show abstract] [Hide abstract]
ABSTRACT: To determine the efficacy of a plasmid containing a small hairpin RNA expression cassette (pSEC.shRNA) against VEGF-A-loaded poly(lactic co-glycolic acid) nanoparticles (PLGA NPs) in the sustained regression of murine corneal neovascularization. PLGA nanoparticles were loaded with pSEC.shRNA.VEGF-A plasmids using the double emulsion-solvent evaporation method. KNV was induced in BALB/c mice by mechanical-alkali injury. Four weeks after induction of KNV, the mice were randomly divided to receive one of four treatments intrastromally: pSEC.shRNA.VEGF-A PLGA NPs (2 μg plasmid); naked pSEC.shRNA.VEGF-A plasmid only (2 μg plasmid); control blank PLGA NPs (equivalent dry weight of NPs); and vehicle. Two and five days after intervention, corneas were harvested to determine VEGF-A gene and protein expression using reverse transcriptase polymerase chain reaction and ELISA, respectively. Four weeks after intervention, corneas were photographed, mice sacrificed, and the corneal whole mounts were immunostained for CD31 (panendothelial cell marker). Immunofluorescence microscopy was performed and the neovascular area was quantitated. VEGF-A mRNA (49.6 ± 12.4 vs. 82.9 ± 6.0%, P < 0.01) and protein (4.0 ± 5.2 vs. 20.0 ± 7.5 ρg VEGF-A/mg total protein, P < 0.05) expression were significantly reduced in pSEC.shRNA.VEGF-A PLGA NP-treated corneas as compared with control blank NP. The pSEC.shRNA.VEGF-A PLGA NP-treated corneas showed significant regression in the mean fractional areas of KNV (0.125 ± 0.042; 12.5%, P <0.01) compared with both naked plasmid only (0.283 ± 0.004; 28.3%) and control (blank NPs = 0.555 ± 0.072, 55.5%) at 4 weeks post-treatment. The pSEC.shRNA.VEGF-A-loaded PLGA NPs are an effective, nonviral, nontoxic, and sustainable form of gene therapy for the regression of murine KNV.Investigative ophthalmology & visual science 03/2012; 53(6):2837-44. DOI:10.1167/iovs.11-9139 · 3.66 Impact Factor
Article: Flt23k Nanoparticles Offer Additive Benefit in Graft Survival and Anti-Angiogenic Effects When Combined with Triamcinolone[Show abstract] [Hide abstract]
ABSTRACT: To determine if nanoparticles delivering plasmids expressing Flt23k (an anti-VEGF intraceptor) can enhance murine cornea transplant survival and whether their effect is synergistic with steroid therapy. Biodegradable PLGA Flt23k loaded or blank nanoparticles were prepared using the emulsion solvent evaporation Graft survival, corneal neovascularization, and corneal lymphangiogenesis were compared among the Flt23k nanoparticles, blank nanoparticles, triamcinolone acetonide, and PBS groups following subconjunctival injection in mice that underwent penetrating keratoplasty. Graft survival, corneal neovascularization, and corneal lymphangiogenesis in a group treated with both nanoparticles and steroid therapy were also analyzed. The Flt23k nanoparticle group showed less neovascularization, lymphangiogenesis, and graft failure compared with the PBS control group (P < 0.01). The 2-month graft survival rate was 20% in the Flt23k nanoparticle group with no grafts surviving in the PBS group. When the Flt23k nanoparticle was combined with steroid therapy, a significant increase in graft survival was seen compared with both steroid treatment alone (P < 0.05) and steroid combined with blank nanoparticle treatment (P < 0.05). The 2-month graft survival rate was 91.6% in the combination group compared with 47.6% in the triamcinolone-only group and 42.4% in the triamcinolone plus blank nanoparticle group. Anti-VEGF nanoparticles (Flt23k) have a significant effect on decreasing neovascularization and lymphangiogenesis, resulting in increased graft survival in penetrating keratoplasty. This beneficial effect is synergistically enhanced with steroid treatment.Investigative ophthalmology & visual science 03/2012; 53(4):2328-36. DOI:10.1167/iovs.11-8393 · 3.66 Impact Factor
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ABSTRACT: Anomalous neuritogenesis is a hallmark of neurodegenerative disorders, including retinal degenerations, epilepsy, and Alzheimer's disease. The neuritogenesis processes result in a partial reinnervation, new circuitry, and functional changes within the deafferented retina and brain regions. Using the light-induced retinal degeneration (LIRD) mouse model, which provides a unique platform for exploring the mechanisms underlying neuritogenesis, we found that retinoid X receptors (RXRs) control neuritogenesis. LIRD rapidly triggered retinal neuron neuritogenesis and up-regulated several key elements of retinoic acid (RA) signaling, including retinoid X receptors (RXRs). Exogenous RA initiated neuritogenesis in normal adult retinas and primary retinal cultures and exacerbated it in LIRD retinas. However, LIRD-induced neuritogenesis was partly attenuated in retinol dehydrogenase knockout (Rdh12(-/-)) mice and by aldehyde dehydrogenase inhibitors. We further found that LIRD rapidly increased the expression of glutamate receptor 2 and β Ca(2+)/calmodulin-dependent protein kinase II (βCaMKII). Pulldown assays demonstrated interaction between βCaMKII and RXRs, suggesting that CaMKII pathway regulates the activities of RXRs. RXR antagonists completely prevented and RXR agonists were more effective than RA in inducing neuritogenesis. Thus, RXRs are in the final common path and may be therapeutic targets to attenuate retinal remodeling and facilitate global intervention methods in blinding diseases and other neurodegenerative disorders.The FASEB Journal 09/2011; 26(1):81-92. DOI:10.1096/fj.11-192914 · 5.48 Impact Factor
Article: Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.[Show abstract] [Hide abstract]
ABSTRACT: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV). The etiology and pathogenesis of CNV and PCV are not well understood. Genome-wide association studies have linked a multifunctional serine protease, HTRA1, to AMD. However, the precise role of HTRA1 in AMD remains elusive. By transgenically expressing human HTRA1 in mouse retinal pigment epithelium, we showed that increased HTRA1 induced cardinal features of PCV, including branching networks of choroidal vessels, polypoidal lesions, severe degeneration of the elastic laminae, and tunica media of choroidal vessels. In addition, HTRA1 mice displayed retinal pigment epithelium atrophy and photoreceptor degeneration. Senescent HTRA1 mice developed occult CNV, which likely resulted from the degradation of the elastic lamina of Bruch's membrane and up-regulation of VEGF. Our results indicate that increased HTRA1 is sufficient to cause PCV and is a significant risk factor for CNV.Proceedings of the National Academy of Sciences 08/2011; 108(35):14578-83. DOI:10.1073/pnas.1102853108 · 9.81 Impact Factor
Conference Paper: Role of Vimentin in Corneal Fibrosis and Wound Healing Process.ARVO; 05/2011
Article: Whirlin Replacement Restores the Formation of the USH2 Protein Complex in Whirlin Knockout Photoreceptors[Show abstract] [Hide abstract]
ABSTRACT: Whirlin is the causative gene for Usher syndrome type IID (USH2D), a condition manifested as both retinitis pigmentosa and congenital deafness. Mutations in this gene cause disruption of the USH2 protein complex composed of USH2A and VLGR1 at the periciliary membrane complex (PMC) in photoreceptors. In this study, the adeno-associated virus (AAV)-mediated whirlin replacement was evaluated as a treatment option. Murine whirlin cDNA driven by the human rhodopsin kinase promoter (hRK) was packaged as an AAV2/5 vector and delivered into the whirlin knockout retina through subretinal injection. The efficiency, efficacy, and safety of this treatment were examined using immunofluorescent staining, confocal imaging, immunoelectron microscopy, Western blot analysis, histologic analysis, and electroretinogram. The AAV-mediated whirlin expression started at two weeks, reached its maximum level at 10 weeks, and lasted up to six months post injection. The transgenic whirlin product had a molecular size and an expression level comparable to the wild-type. It was distributed at the PMC in both rod and cone photoreceptors from the central to peripheral retina. Importantly, the transgenic whirlin restored the cellular localization and expression level of both USH2A and VLGR1 and did not cause defects in the retinal histology and function in the whirlin knockout mouse. Whirlin transgene recruits USH2A and VLGR1 to the PMC and is sufficient for the formation of the USH2 protein complex in photoreceptors. The combined hRK and AAV gene delivery system could be an effective gene therapy approach to treat retinal degeneration in USH2D patients.Investigative ophthalmology & visual science 04/2011; 52(5):2343-51. DOI:10.1167/iovs.10-6141 · 3.66 Impact Factor
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ABSTRACT: It is known that SPARC gates VEGF-A signal transduction towards KDR, the primary angiogenic VEGF receptor. We sought to determine whether inhibition of SPARC activity using anti-SPARC peptide could inhibit laser-induced CNV by promoting binding of VEGF-A to FLT-1. We created anti-SPARC l-peptide and retro-inverso anti-SPARC d-peptide. Anti-SPARC peptides or PBS were injected intravitreally 1day before or after laser induction. Intravitreal injection of anti-SPARC l-peptide 1day before laser induction promotes FLT-1 phosphorylation and inhibited laser-induced CNV and anti-SPARC d-peptide had no effect. Injection 1day after laser injury did not affect size of laser-induced CNV. Inhibition of SPARC activity could be complementary to existing anti-CNV therapy.Vision research 12/2009; 50(7):674-9. DOI:10.1016/j.visres.2009.12.003 · 2.38 Impact Factor
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ABSTRACT: Age-related macular degeneration is the most common cause of irreversible visual impairment in the developed world. Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown. We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent. We also tested for the effect of TLR3 Leu and Phe variants on the viability of human retinal pigment epithelial cells in vitro and on apoptosis of retinal pigment epithelial cells from wild-type mice and Tlr3-knockout (Tlr3(-/-)) mice. The Phe variant (encoded by the T allele at rs3775291) was associated with protection against geographic atrophy (P=0.005). This association was replicated in two independent case-control series of geographic atrophy (P=5.43x10(-4) and P=0.002). No association was found between TLR3 variants and choroidal neovascularization. A prototypic TLR3 ligand induced apoptosis in a greater fraction of human retinal pigment epithelial cells with the Leu-Leu genotype than those with the Leu-Phe genotype and in a greater fraction of wild-type mice than Tlr3(-/-) mice. The TLR3 412Phe variant confers protection against geographic atrophy, probably by suppressing the death of retinal pigment epithelial cells. Since double-stranded RNA (dsRNA) can activate TLR3-mediated apoptosis, our results suggest a role of viral dsRNA in the development of geographic atrophy and point to the potential toxic effects of short-interfering-RNA therapies in the eye.New England Journal of Medicine 09/2008; 359(14):1456-63. DOI:10.1056/NEJMoa0802437 · 54.42 Impact Factor
Article: Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.[Show abstract] [Hide abstract]
ABSTRACT: Significant morbidity and mortality among patients with diabetes mellitus result largely from a greatly increased incidence of microvascular complications. Proliferative diabetic retinopathy (PDR) and end stage renal disease (ESRD) are two of the most common and severe microvascular complications of diabetes. A high concordance exists in the development of PDR and ESRD in diabetic patients, as well as strong familial aggregation of these complications, suggesting a common underlying genetic mechanism. However, the precise gene(s) and genetic variant(s) involved remain largely unknown. Erythropoietin (EPO) is a potent angiogenic factor observed in the diabetic human and mouse eye. By a combination of case-control association and functional studies, we demonstrate that the T allele of SNP rs1617640 in the promoter of the EPO gene is significantly associated with PDR and ESRD in three European-American cohorts [Utah: P = 1.91 x 10(-3); Genetics of Kidneys in Diabetes (GoKinD) Study: P = 2.66 x 10(-8); and Boston: P = 2.1 x 10(-2)]. The EPO concentration in human vitreous body was 7.5-fold higher in normal subjects with the TT risk genotype than in those with the GG genotype. Computational analysis suggests that the risk allele (T) of rs1617640 creates a matrix match with the EVI1/MEL1 or AP1 binding site, accounting for an observed 25-fold enhancement of luciferase reporter expression as compared with the G allele. These results suggest that rs1617640 in the EPO promoter is significantly associated with PDR and ESRD. This study identifies a disease risk-associated gene and potential pathway mediating severe diabetic microvascular complications.Proceedings of the National Academy of Sciences 06/2008; 105(19):6998-7003. DOI:10.1073/pnas.0800454105 · 9.81 Impact Factor
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ABSTRACT: Exfoliation glaucoma (XFG) is the commonest identifiable cause of secondary open-angle glaucoma worldwide, characterized by the deposition of fibrillar proteins in the anterior segment of the eye. We investigated LOXL1 gene variants previously identified to confer susceptibility to XFG in a Utah Caucasian cohort. After a standard eye examination protocol we genotyped SNPs rs2165241and rs3825942 in 62 XFG or exfoliation syndrome (XFS) patients and 170 normal controls. Genotype frequency distribution, odds ratios (ORs) and population attributable risks were calculated for the risk alleles. The SNP rs2165241 was significantly associated with XFG and XFS (p = 4.13 x 10(-9)) for an additive model, OR(het) = 4.42 (2.30-8.50), OR(hom) = 34.19 (4.48-261.00); T allele: 83.1% in cases versus 52.4% in controls). Significant association was also found for rs3825942: (p = 1.89 x 10(-6)). Our findings confirm genetic association of LOXL1 with XFG and XFS and implicate a potential role of cross linking of elastin in the pathogenesis of XFG. This information will potentially guide glaucoma monitoring efforts by targeting individuals whose genetic profiles put them at higher risk for XFG.Cell cycle (Georgetown, Tex.) 03/2008; 7(4):521-4. DOI:10.4161/cc.7.4.5388 · 5.01 Impact Factor
Article: Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration[Show abstract] [Hide abstract]
ABSTRACT: Single nucleotide polymorphism (SNP), rs11200638, in the promoter of HTRA1 has recently been shown to increase the risk for AMD. In order to investigate the association of this HTRA1 polymorphism and the bilaterality of AMD, we genotyped rs11200638 in control, unilateral, and bilateral advanced AMD patients. The A allele for SNP rs11200638 in HTRA1, was significantly more prevalent in bilateral wet AMD and GA patients than in unilateral groups (p=.02 and p=.03, respectively). The homozygote odds ratios of bilateral wet AMD and GA are significantly greater than those seen in unilateral groups (twofold and threefold increase, respectively). This finding is consistent with the role of HTRA1 in AMD pathogenesis and will help aid in the clinical management and prognosis of AMD patients.Vision Research 03/2008; 48(5):690-4. DOI:10.1016/j.visres.2007.10.014 · 2.38 Impact Factor
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ABSTRACT: We examined familial aggregation and risk of age-related macular degeneration in the Utah population using a population-based case-control study. Over one million unique patient records were searched within the University of Utah Health Sciences Center and the Utah Population Database (UPDB), identifying 4764 patients with AMD. Specialized kinship analysis software was used to test for familial aggregation of disease, estimate the magnitude of familial risks, and identify families at high risk for disease. The population-attributable risk (PAR) for AMD was calculated to be 0.34. Recurrence risks in relatives indicate increased relative risks in siblings (2.95), first cousins (1.29), second cousins (1.13), and parents (5.66) of affected cases. There were 16 extended large families with AMD identified for potential use in genetic studies. Each family had five or more living affected members. The familial aggregation of AMD shown in this study exemplifies the merit of the UPDB and supports recent research demonstrating significant genetic contribution to disease development and progression.Vision Research 03/2008; 48(3):494-500. DOI:10.1016/j.visres.2007.11.013 · 2.38 Impact Factor
Article: HTRA1 Variant Confers Similar Risks to Geographic Atrophy and Neovascular Age-related Macular Degeneration[Show abstract] [Hide abstract]
ABSTRACT: Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. The two forms of advanced AMD, geographic atrophy (GA) and choroidal neovascularization (wet AMD), represent two types of degenerative processes in the macula that lead to loss of central vision. Soft confluent drusen, characterized by deposits in macula without visual loss are considered a precursor of advanced AMD. A single nucleotide polymorphism, rs11200638, in the promoter of HTRA1 has been shown to increases the risk for wet AMD. However, its impact on soft confluent drusen and GA or the relationship between them is unclear. To better understand the role the HTRA1 polymorphism plays in AMD subtypes, we genotyped an expanded Utah population with 658 patients having advanced AMD or soft confluent drusen and 294 normal controls and found that the rs11200638 was significantly associated with GA. This association remains significant conditional on LOC387715 rs10490924. In addition, rs11200638 was significantly associated with soft confluent drusen, which are strongly immunolabeled with HTRA1 antibody in an AMD eye with GA similar to wet AMD. Two-locus analyses were performed for CFH Y402H variant at 1q31 and the HTRA1 polymorphism. Together CFH and HTRA1 risk variants increase the odds of having AMD by more than 40 times. These findings expand the role of HTRA1 in AMD. Understanding the underlying molecular mechanism will provide an important insight in pathogenesis of AMD.Cell cycle (Georgetown, Tex.) 05/2007; 6(9):1122-5. DOI:10.4161/cc.6.9.4157 · 5.01 Impact Factor
Article: Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival[Show abstract] [Hide abstract]
ABSTRACT: Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it. We generated Elovl4 Y270X mutant mice and characterized the homozygous mutant as well as homozygous Elovl4 knockout mice in order to better understand the function or role of Elovl4. We found that mice lacking a functional Elovl4 protein died perinatally. The cause of death appears to be from dehydration due to faulty permeability barrier formation in the skin. Further biochemical analysis revealed a significant reduction in free fatty acids longer than C26 in homozygous mutant and knockout mouse skin. These results implicate the importance of these long chain fatty acids in skin barrier development. Furthermore, we suggest that Elovl4 is likely involved in the elongation of C26 and longer fatty acids.International journal of biological sciences 02/2007; 3(2):111-9. · 4.37 Impact Factor
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University of Utah
Salt Lake City, Utah, United States
- Department of Ophthalmology and Visual Sciences
Sichuan Academy of Medical Sciences & Sichuan Provincial People's HospitalHua-yang, Sichuan, China


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Top Definition
A variety of pubitanglia which only occurs during the time when the penis is becoming erect "extending". Sometimes referred to extendapubitanglia. Unlike repubitanglia where pubic hair becomes entangled under the foreskin, in expubitanglia, the pubic hair becomes wrapped over or around the head of the penis and is trapped by tight fitting underwear. This condition can be avoided by regularly trimming the pubic hair.
You can tell he's got expubitanglia because of the way he walks.
by Felatio Do Good April 02, 2010


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Thursday, May 23, 2013
Browning has added five new knives to its popular Black Label line: the Backlash, the Checkmate, the Fear Factor, the Trip Wire and the Strike Force. Each is designed with a rugged construction that's meant to make it ideal for everyday use or self-defense.
The Backlash is a double-edged fixed blade knife made from 440 stainless steel. It's handle is CNC machined G-10 composite, and is available in black or coyote tan.
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Feels like heaven, when I'm playing them. Really...
i am...:-)
Best Answer
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Food and Drink
This "Food and Drink" section of our site features all the interesting and innovative food and drink products from around the globe as well as all the products for making, serving, storing food and drink items on InventorSpot.com.
Some of our more popular articles include:
- Must Tastes: 20 Wild & Weird Potato Chip Flavors
- Unhappy Meals: China's Top 8 Fake Foods
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- Coffee Copies: The Top 7 Chinese Starbucks Ripoffs
- The Top Ten Strange and Unusual Japanese Chewing Gums
- 10 Best Gourmet Chocolates All Dressed Up For Valentine's Day
Subscribe to our latest "Food and Drink" articles.
Jump Start Your Tipsiness With A Set Of Tipsy Wine Glassesby Kim Patterson
You pour; you sip and you wait for that wave of relaxation to take hold. It's a great way to unwind, but what if you could start out with a little tipsiness? Tipsy Wine Glasses by Big Mouth Toys will put a smile on your face. These hand-blown glasses are a little off, in a good way.
Unhappy Meals: China's Top 10 Fake Foodsby China.new
China's 1.3 billion people are hungry for wealth and riches. Too often, however, making a buck means taking a buck by foisting imitation nutrition on the unwary. These top 10 Chinese fake foods and drinks may leave a bad taste in your mouth but consider yourself lucky you're just reading, not eating.
The Crunch Before Lunch: Banana & Peach Flavored Breakfast Potato Chipsby Steve Levenstein
In an effort to jump start the so-called "morning potato chips habit", Japan's Koikeya is rolling out two new fruit-flavored potato chips: Banana and Peach. No need to import them here – American college students have already got the morning potato chips habit down pat.
The Invention Of Coke Motivates 'Mad Men' Finale & 'Happyish' Entréeby Ron Callari
Where an iconic TV show ends, another begins. Mad Men and Happyish are separated by eight years in real-time but actually over 50 years in their respective fictional timelines. Both plots focus on the inner-workings of an advertising agency. The former documents how we were romanced into believing in promotional hype, while the latter's reality check is a result of a healthy dose of buyer-beware skepticism and a growing. . .
The One Kitchen Mixer No Home Gourmet Should Be Withoutby Rebecca West
If cooking and baking are your passion, we've found a mixer no chef or home gourmet should be without. Check out which kitchen mixer has been voted #1 with consumers and start dropping hints for Mother's Day now.
Induction Cooking: Which Is The Best Induction Cooker?by Rebecca West
Induction cooking is all the rage right now due to its convenience and energy efficiency. With so many of them to choose from, how do you know which one is the best? We've done a lot of the legwork for you in narrowing down which induction cooker is currently the most popular with shoppers and consumer review sites, saving you both time and trouble. Come see what we've found.
Want Something New In A Banana? Well, Stuff It!by Laurie Kay Olson
For the most part the same old banana is just the same old banana -- that is unless you choose to stuff it. But how does one stuff a banana? It is hardly like filling a cannoli, which is hollow. Enter the DestapaBanana, a gadget that allows you to fill the popular fruit with whatever you can think of -- either solid or liquid. While most people are going to think first of a banana filled with chocolate syrup or chocolate pudding, but there is so much more out there to experiment with!
Electric Rice Cookers: Which Is The Best?by Rebecca West
Considering buying an electric rice cooker but confused about which one to buy? We've found two that rank high in customer satisfaction and offer a range of cool cooking features. From brown rice, white rice, long grain and wild rice, these electric rice cookers make perfectly cooked rice every time.
Puj PhillUp Allows Kids To Grab Their Own Drinks Of Waterby Kim Patterson
You're right in the middle of some important task that you can't put down, have just stepped into the shower, or your butt has finally grazed the top of the lounge chair for the first time all day when one of of the kids bellows, "Can I have a glass of water?" The people a Puj feel your pain and, as such, have created the PhillUp in response to your predicament.
Want To Taste Spring With Your Burger? Get Sakura Friesby Laurie Kay Olson
McDonald's has been celebrating spring in Japan with Sakura Fries. Sakura is Japanese for the cherry blossom and said blossom is the iconic symbol of the season for the island nation. The burger giant is offering small packets of "sakura" seasoning to their patrons so they can add it to their fries if they so choose. It is the perfect thing for people who love to try unusual flavors.


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Educational Resources: Search the CLEAN Collection
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Revenge's Josh Bowman Can't Keep His Hands Off Co-Star Girlfriend Emily VanCamp (PHOTO)
Daniel Grayson caught Emily Thorne kissing Jack Porter at the end of Revenge's first season, but that doesn't seem to have affected the actors' real-life relationship.
Co-stars Josh Bowman and Emily VanCamp have been dating since around January 2012. Though the couple is very private, they have been spotted out together looking rather cozy all around the globe.
They played with penguins in Australia, flirted in Los Angeles nightclubs, sported formal wear in Monte Carlo, and got frisky at a pool in Monaco.
Now the Brit and the Canadian are back in California filming the second season of our favorite show, and though Daniel is set to hook up with Ashley Davenport this season, and Ems has a new boy toy in town, these cuties seem more than happy off-screen.
On Saturday, Sept. 1, the couple was spotted out in West Hollywood grabbing breakfast and sharing a kiss. According to the photo agency Splash News, Josh couldn't keep his hands off Emily as they strolled around in the sunshine.
What do you think of Emily and Josh as a couple? Will they last? Weigh in below!
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The Colburn Community School of Performing Arts schedule of classes is published three times a year for fall, spring, and summer semesters. It provides information on classes offered by the Community School of Performing Arts and the Trudl Zipper Dance Institute. It also offers registration timelines, tuition, and fee information for all classes, ensembles, and private lessons.
Want to know when your first day of class is? Need more information on summer camps and workshops?
Click to Download 2015 Summer Schedule of Classes
Begins Monday, May 4 for continuing studentsBegins Monday, May 11 for new students
Register early to ensure a spot in class. Waiting lists will be created once a class has reached capacity.
STUDENTS MAY REGISTER ONLINE FOR CAMPS STARTING APRIL 1 by clicking here
Will be available at the end of June. Please check back here for the latest information.


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And until my last 3 visit to the doct I never saw the same doct it was always a diferent person and I they have never tell me the weight of my baby is that normal have any of that even happen to any of you guys ?
I'm 38 weeks
Comments (4)
Posted 10/03/2012
I haven't heard how much she weighs in a long time. Whenever I used to get diagnostic ultrasounds they would tell me. I'm 37 weeks 4 days and the last I heard her weight was 1.4 pounds so you can imagine how long ago that was. I don't stress though because the doctors are wrong a lot too. My sister was told she had to get a c section because her baby was going to be over 10 pounds and they didn't want his collar bone to break and after she had him we found out he was 7 lbs. so don't freak out honey we are almost there! :) it's a little weird they never told you. If you want you can mention that to them and hopefully they will give you an ultrasound and let you know. Hope this helps :)
Posted 10/03/2012
I'm 38 weeks as well and I really have no idea what is going on. It's been like this my entire pregnancy. Ever since I was diagnosed with GD, I have seen a different doctor each time. They keep asking me who my doctor is and I'm like "I have no idea, please, you tell me". The only ultrasound I received was the 20 week scan, and they have never told me how big they suspect she will be. I go in for a growth scan 3 days before my induction lol. My next appointment is also 3 days before my induction, and they have never checked my cervix. Sometimes, they just don't seem to have time for you. Best of luck!
Posted 10/03/2012
I just had my 40w checkup and the dr guestimated that LO was around 7ish lbs. That was the first time the dr ever guessed weight. The other times were from my ultrasounds. But, as PP said...not all estimates are correct or even close!
Becca, Marine Wife to Justin <3 10-9-10 <3
What's on your mind?Create a new post
Your growing child
Your 32-month-old: Let's pretend
Pretend play is becoming one of your child's favorite things. Read More
Your 32-month-old: Nap-time strategies
An afternoon nap helps rambunctious preschoolers recharge and stay pleasant till bedtime. Read More
Your 32-month-old: Intro to manners
Your child is definitely old enough to learn — and practice — some of the social graces. Read More
Your 33-month-old: Taming fears
A lively imagination often gives temporary birth to monsters. Read More


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August 2014, TruckingInfo.com - Cover Story
By Staff
There are many ways to tell a story – through words in books and magazines, pictures, videos, song, and more. With the inaugural issue of the HDT Fact Book, we are telling trucking's story through facts, numbers, statistics, charts, and graphs.
Tags: Emissions, Drivers, Equipment, Statistics, Parts, industry statistics, Fuel and Oil
January 2013, TruckingInfo.com - Feature
By Deborah Lockridge
Highway funding, driver respect and fixing CSA are on HDT Editor in Chief Deborah Lockridge's wish list for 2013.
Tags: Drivers, Infrastructure, CSA
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Mark Betner from CITGO, will answer your questions
The expert, Rence Oliphant from Hendrickson, will answer your questions
Eaton Expands Flex Reman Transmission Lineup
ARI Adds Custom Dashboards to Fleet Management System
TruckTech+ Provides Diagnostics to Fleets and Dealers
ALK Adds HOS Manager to PC Miler


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November 3, 2012
Video: Kelly proud of Golson
Jack Freeman
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NOTRE DAME, Ind. - Brian Kelly talked about his decision to bench Everett Golson and then put the game in the sophomore's hands following Notre Dame's triple overtime escape.
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Tags Matching:
synoptic gospels
Originally published 02/17/2013
Jim Cullen: Review of Colm Toibin's "The Testament of Mary" (Scribner, 2012)
Jim Cullen, who teaches at the Ethical Culture Fieldston School in New York, is a book review editor at HNN. His new book, Sensing the Past: Hollywood Stars and Historical Visions, was published last month by Oxford University Press. Cullen blogs at American History Now.
- 150 years later, schools are still a battlefield for interpreting Civil War
- Where are America's memorials to pain of slavery, black resistance?
- Richmond split over Confederate history
- The World's Jewish Population Is Nearing Pre-Holocaust Levels
- Bernie Sanders's Revolutionary Roots Were Nurtured in '60s Vermont
- Did a historian who said he's a victim of McCarthyism get the story wrong?
- Stephanie Coontz's work on the history of marriage cited by the Supreme Court.
- How Does It Feel To Have One's Work as a Historian Cited by the Supreme Court? Cool. Very Cool. Thank You Very Much.
- NYT History Book Reviews: Who Got Noticed this Week?
- David Hackett Fischer wins $100,000 prize for lifetime achievement in military writing


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A Jpeg Resizer is a must have software for any amateur ... protecting your photos by adding watermarks. The JPEG Resizer can be used to make size of your ... simply to save space on your hard or flash drive. The highest quality possible is also preserved in the files. Jpg Resizer also provides the Try program for free by .... Free download of Jpeg Resizer 4.0.4
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Published: Sunday, August 1, 2010 at 6:01 a.m.
Last Modified: Friday, July 30, 2010 at 10:31 p.m.
Jenna Beth Early and Joshua Aaron Rogers were married June 26 at Altoona Methodist Church.
The bride is the daughter of Wayne and Dana Early. Parents of the groom are Tony and Rhonda Rogers.
The ceremony was performed by the Rev. Gary Brittain. Music was performed by Beth Anne Lawrence.
Given in marriage by her father, the bride was attended by Jillian Early as maid of honor. Bridesmaids were Hannah Christopher and Lindsey Holcombe. Flower girls were Olivia Tucker and Zoe Tucker.
Best man was Bryan Price. Groomsmen were Kevin "Fluffy" Studdard and David Jennings. Ushers were Jacob Early and Dan Hopper. Ringbearers were Luke Sligh and Wyatt Sligh.
A reception was held at Altoona Methodist Church Fellowship Hall.
After a wedding trip to Gatlinburg, Tenn., the couple reside in Madison, Ala.
An after-rehearsal dinner was given by the groom's parents at La Cabana Restaurant in Walnut Grove.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Register now for free, or sign in with any of these services:
Status: Open
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Description: Bienville House Hotel offers a range of lodging and dining options. It provides a variety of guest rooms and suites. The hotel s amenities feature a courtyard, swimming pool and various landscaped wrought iron balconies. Each of its suites features down pillows, hairdryers, wireless Internet access and coffeemakers. Its guest room features deluxe bathrobes, hairdryers, iron and...
Bienville House is a French Quarter hotel in New Orleans near Jackson Square, the New Orleans Convention Center, and the best New Orleans restaurants.
A member of Summit Hotels & Resorts and Historic Hotels of America
Home to Southern hospitality, this New Orleans hotel offers guests 83 luxury rooms on the cusp of the French Quarter. Read More
Home to Southern hospitality, this New Orleans hotel offers guests 83 luxury rooms on the cusp of the French Quarter.
It was a great location and wonderful staff! Only complaint would be our air not working properly so the room was very warm!
Bra hotell med bra service och vacker atmosfär. Först fick vi ett rum utan fönster som luktade mögel men det var inga problem att byta till ett bättre rum utan kostnad. Mycket vackert inuti med en liten gård med en pool. En fin frukost ingick. Hotellet ligger i bästa läget, centralt och nära floden.
Since 1986 the company has been providing Hotels.
This romantic hotel is within close proximity of Jean Lafitte National Historical Park and Preserve Visitor Center and Woldenberg Park.


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1 Cut the avocado and scoop out the pulp.
2 Mash the pulp using a fork.
3 Add in the Guacamole mix a little at a time and mix well to combine with the avocado pulp.
4 Combine the taco seasoning with refried beans and mix well.
5 Finely cut the scallions and lettuce.
6 In a large glass dish, spread an even layer of refried beans.
7 Spread a thin layer of prepared guacamole over the refried beans.
8 Cover the guacamole with an even layer of salsa.
9 Sprinkle chopped lettuce and scallions over salsa to form another layer.
10 You can refrigerate the dip at this stage.
11 Sprinkle a layer of cheese just before serving along with a few dollops of sour cream.


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I am perplexed by the so- so reviews. The hotel was beautiful, with a fresh Scandinavian / Vermont feel. The room was spacious, clean and modern with top of the line bedding, towels and products. Most items in the room from the coffee mugs to the water pitcher ,to the glass soap dishes , were made locally, and available for purchase . It was a great way to get a feel for modern Vermont with out the old granny/ plaid/ maple syrup New England theme. The staff was friendly and quite welcoming.
We had cocktails outside on one of the two roof decks, which was a quiet respite from the more noisy church street. Brunch at juniper was delicious, locally sourced and quite reasonable. I have been coming to Burlington for the past five years and this is by far my favorite hotel. I felt comfortable, well cared for, and inspired by this great new take on Vermont cool.


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2780 Reservoir Avenue
Bedford Park, New York, 10468
Commute to Downtown Fort Lee
Daily errands do not require a car.
World-class public transportation.
Flat as a pancake, some bike lanes.
Score Details
2780 Reservoir Avenue has a Walk Score of 94 out of 100. This location is a Walker's Paradise so daily errands do not require a car.
2780 Reservoir Avenue is a five minute walk from the 4 Lexington Avenue Express at the Kingsbridge Rd stop.
This location is in the Bedford Park neighborhood in New York. Nearby parks include Barnhill Triangle, Old Fort Park and John R Brown Triangle.
Explore how far you can travel by car, bus, bike and foot from 2780 Reservoir Avenue.
2780 Reservoir Avenue is a Rider's Paradise which means world-class public transportation. Car sharing is available from Zipcar and RelayRides.
Rail lines:
4 Lexington Avenue Express
0.2 mi
B 6 Avenue Express
0.3 mi
D 6 Avenue Express
0.3 mi
1 Broadway - 7 Avenue Local
0.7 mi
0.7 mi
New Haven
0.7 mi
New Canaan
0.7 mi
0.7 mi
Bus lines:
Bx32 Kingsbridge VA Hospital - Mott Haven
0.1 mi
Bx22 Bedford Park - Castle Hill
0.1 mi
Bx38 Co-op City Bay Plaza - Norwood
0.1 mi
Bx28 Co-op City Section 5 - Fordham Center
0.1 mi
Bx9 Riverdale - West Farms Sq
0.2 mi
Bx3 Riverdale - George Washington Bridge
0.2 mi
Car shares:
View all Bedford Park apartments on a map.
Find a New York real estate agent who knows walkable neighborhoods. Links will open on our partner site Redfin.com.
2780 Reservoir Avenue is in the Bedford Park neighborhood. Bedford Park is the 84th most walkable neighborhood in New York with a neighborhood Walk Score of 91.
Moving to New York from another city? View our moving to New York guide.


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Do you know what the special thing is? Or is it a surprise? I'm dying to know now! lol
Do you know what the special thing is? Or is it a surprise? I'm dying to know now! lol
Oops double post. Oh well, don't want this one to go to waste!
I'm so incredibly tired. I got about 2.5-3 hours of sleep this afternoon in preparation for the start of my overnight cycle. I hope it's a quiet night because my brain is going to functioning on minimum.
Wooo Ducks beat the Sharks!
Oops I meant the Stars. I knew it was Dallas lol
Yeah I wasn't lying!
I think the Sharks actually won their game, too.
Funny story that Amanda will like - at DCA my husband was wearing his Coyotes hat. A Photopass CM stopped us while we were walking and she's all "I see you're wearing a Coyotes hat" so I'm like "Oh Jeez are you a Kings fan?" And she said "*gasp* don't insult me like that!!", I said "Who then? Ducks?" Then she takes her arms and makes a big chomping motion and goes "SHARKS, BABY!" hahaha
Hahahaha! That's the reason why I don't like going to to Hawks and Kings games, I don't want to get shot or end up in jail.
^Exactly, I'd be afraid to see the Ducks when they're visiting the Kings. Or even worse, when my Angels visit the Dodgers.
I could go to DL tomorrow but it probably won't happen because I'm tired and the wait times I saw don't like great. (Spoiled AP who doesn't like waiting right here!)
Haha I know what you mean about being spoiled. I hate waiting more than 30 minutes for anything.
Gremlins 2 is on, so I'm tempted to stay awake and watch it... But I better try and get to sleep. I'm exhausted!
Good night/morning!
Hahaha Gremlins 2. Gotta love that movie, it tried. It was bad in such an awesome way. Rumor has it they're making another one.
Thanks for all the hair complements. I just do it because I like it. I kind of wish my hair was still rainbow for Bat Day coming up. All those goths... and me with bright-*** rainbow hair. LOL.
I know what the thing is, my husband only knows part of it. I just don't want to jinx it. It's one of those once in a lifetime things, offered to us by someone we haven't really met... I'm worried if I say anything specific about it, it will be a con and it will fall through. You know? If it does happen, I'm totally writing a trip report, though!
How was your first overnight?
Peter Pan: "You know, your hair is on fire."
Me: "Yes. It happened after a recent trip to Neverland."
Peter Pan: "Well, you can dunk your head in the pond behind us, if you want."
Lost Child of Neverland since 1996.
~Favorite Hero: Peter Pan. Favorite Villian:Malificent.Favorite Ride: The Haunted Mansion.~
I wanted to go to Bats day so bad!! Of course it's during my cycle of nights, as everything else seems to be. I'm not goth or anything, but I would love to dress up like one for a day at the parks. So fun!
My first overnight was great! I was super sleepy and exhausted since I only had a couple hours of sleep yesterday, but it went by somewhat quickly despite being slow. That combination is a perfect shift!
I only got about 4 hours of sleep today. I should be sleeping right now but can't. Ugh. Hopefully tonight's shift will be equally as pleasant.
I'm going to the hockey game tonight so I'm going to work late. That should help the shift go by a little quicker!


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lol why are they making a Purge 2..
I didn't even bother seeing the first movie.
Drank half a bottle of Nyquil last night, weirdest dreams ever, one of them had a fortune teller reading my nutsack instead of my hand. What could that possibly mean?
Sir Thomas Richard Coughlin The Great
ahhh yess all the stupid April 1st threads.
Sir Thomas Richard Coughlin The Great


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Risk Management
Who's the client? A trip to Ethics Boot Camp
Many in-house lawyers have found themselves in the spotlight, not for things they did, but for things they didn't do and failing in their ethical duties.
Blowing away the BYOD and social media blues
Cost savings and convenience are one thing, but what happens when bring your own device (BYOD) policies go wrong? Panelists at InsideCounsel's 15th annual SuperConference explore.
Developing bring-your-own-device programs for a global workforce
With careful planning and understanding of local laws, multinational employers can help to achieve the "win-win" value proposition of BYOD for both employer and employees.
Turning risk to advantage
The 15th annual SuperConference kicked off in Chicago this week with the Global Lawyer Forum, a day dedicated to thought leaders discussing matters relevant to multinational corporate counsel.
Lessons counsel should learn from the GM ignition switch failure
Whether your company's issue is safety or compliance with a federal or state regulation, create the right culture. Make sure one individual within your legal department takes ownership of that issue.
Legal landscape for cybersecurity risk is changing as federal government and SEC take action
In 2014, many of the most recognizable companies in America fell prey to cyber attacks. In the face of the clear threat posed by these attacks, the federal government has taken steps to respond.
The future of compliance
These days, organizations in diverse sectors are recognizing that technology solutions can improve compliance functions and reduce overall risk.
Understanding and managing global cyber risk
The cyber issue is fundamentally global, here today, and will continue to grow as companies drive more innovation through the use of technology.
What is your tweet worth? (Part 2)
In this second and final installment, Haas explains the volatility of IP assets, and Tom Leavens, general counsel of Pitchfork Media, weighs in as well.
Catching traders before they go rogue
JPMorgan Chase's new initiative seeks to spot patterns in data that will alert them to possible future wrongdoing.


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Salmon Willow Trail
Salmon Willow Trail is in the southern Gore Range, part of the Rocky Mountains in the U.S. state of Colorado. It is located in the Eagles Nest Wilderness, Summit County. Salmon Willow Trail is north of Interstate 70, west of Highway 9, in Silverthorne. It connects the Gore Range Trail with Salmon Lake and the Willow Lakes that lie against Willow Peak and feed North Willow Creek.
The Salmon Willow trailhead is located in Willowbrook subdivision of Silverthorne. Approximately an hour up from the trailhead, the Salmon Willow Trail meets the Gore Range Trail at the base of Red Peak. The Gore Range trail proceeds north, meeting a junction with the Salmon Willow Trail. The Salmon Willow Trail ascends moderately, rising west into the valley between Red Peak and Willow Peak. Bearing to the right at the next junction, a trail leads to Salmon Lake, named for the pink boulders that surround this alpine lake. Proceeding straight to the ragged amphitheater formed by the mountains, a series of ponds lie ahead, feeding North Willow Creek. The Willow Lakes are two miles from the intersection with the Gore Range Trail. In summer, the broad valley is covered with the blossoms of high alpine and tundra wildflowers. Greatest Hikes in Central Colorado: Summit and Eagle Counties, a hiking guide by Kim Fenske, provides a description of Salmon Willow Trail.
See also[edit]
- ASIN B003ZUY8NM, Greatest Hikes in Central Colorado: Summit and Eagle Counties
- Forest Service Message: Respect the river
- Wild Colorado: Moose, the majestic beast
External links[edit]
- "Upper Willow Lakes/Salmon Lake Trail #36". White River National Forest. U.S. Forest Service. Retrieved 2013-12-26.
Coordinates: 39°42′39″N 106°10′02″W / 39.71075°N 106.16716°W