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Allows adoption agencies that contract with the state to cite religious grounds when declining service to prospective parents
Michigan Governor Rick Snyder signed a series of controversial adoption bills into law on Thursday (11 June) that critics say gives adoption agencies the legal right to discriminate against LGBTI people and others.
House Bills 4188, 4189 and 4190 allow agencies that contract with the state to cite religious grounds when declining service to prospective parents.
Lesbian partner of woman who gave birth to twins recognized as second mother at birth
The partner of a woman who gave birth to twins was automatically recognized at birth as the babies' mother, in a landmark ruling in Tel Aviv, Israel this week.
Before the children's birth, the couple, who have been together for nine years, filed a petition to recognize the non-birth mother as a parent, to speed up the official process of adoption.
The usual process would involve going through the complicated legal adoption process after the birth of the child - often taking months or even years to complete.
Get to know the ins and outs of UK adoption laws, explained by specialist fertility and family law firm Natalie Gamble Associates
There has been a revolution of law in England and Wales for same-sex families over the past decade.
Adoption law changes have been a key part of that, and England now has one of the most supportive legal frameworks in the world for gay and lesbian adopters.
In fact, UK law has never barred gay and lesbian parents from adopting, and there have been cases of gay adoptions going back many years.
But until 2005, couples could not adopt jointly which meant that, when same-sex couples adopted, only one partner could become the legal parent.
Faith-based adoption agencies should be able to refuse to place a child in the care of same-sex couples, according to Australian Christian Lobby
Adoption agencies are at risk of closure unless they are allowed to show preferential treatment to heterosexual families, an Australian religious pressure group warns.
In a submission to the government in Victoria, the Australian Christian Lobby are looking to introduce a 'religious exemption' clause, that would give faith-based agencies the right to choose which couples can and cannot adopt children, according to the beliefs of the agency.
Couple barred from adopting the children they co-parent because it would have 'negative impact' on them will appeal court's decision
A Taiwanese lesbian couple are fighting against a decision stopping them from adopting their children.
In the first case of its kind in the country, Neal Wang hopes to formally adopt the twins she co-parents with her partner of 15 years, Ashley Chou.
Chou gave birth to the children six years ago via artificial insemination - but under Taiwanese law, the unmarried partner of a birth mother is not allowed to adopt her children.
An increasing number of LGBT people are coming forward to adopt
The UK's Department of Education announced this week that adoption rates by LGBT parents have it a record high.
Loving, stable homes have been offered to more than 480 children in the past 12 months, thanks to LGBT couples and individuals.
The news comes as part of the UK's LGBT Adoption and Fostering Week, taking place until 8 March 2015, marking the contribution and commitment of the nation's LGBT adopters and foster carers.
Peter Morris, a partner, and Sue Parkinson, a trainee solicitor, with UK-based law firm Irwin Mitchell, look at some of the legal complications that may be involved with adopting; some of which can arise after a child has already joined your home
Adoption is permanent, involving the severing of ties between a child and their birth family.
Adoption is a positive way of assisting children to find a permanent, safe and loving home, and the child's lifelong welfare is the paramount consideration.
Gay and lesbian singles as well as same-sex couples can adopt a child in the UK.
There are clear examples of a same sex placement being the best option for the child. These can include cases involving children with a background of emotional or physical abuse from a parent of a particular gender.
Top court says the law contravenes the European Human Rights Convention
Austria's top court yesterday (14 January) lifted a ban on gay adoption, bringing the country into line with many other EU countries.
The Constitutional Court said the law contravened the European Human Rights Convention.
Explaining the decision, chief judge Gerhart Holzinger said there was 'no objective argument for a differing rule based solely on sexual orientation' of the parents.
Previously, only married couples were allowed to adopt but gay marriage is not legal in Austria.
The women, who married in November and adopted two young boys in December, are believed to the first same-sex couple to legally adopt in the state
A same-sex couple made history last month when they adopted two young boys in Oklahoma.
An attorney acting for the female couple said that she believed it to be the first such same-sex adoption to legally take place in the state.
The adoption was granted on 19 December but the couple's attorney, Terri Craig, only spoke out about the case this week.
The couple, from Okmulgee County, have chosen to remain anonymous but are happy for their case to be publicized.
Ahead of the holiday season, county supervisors have said that adoption procedures are to be streamlined; and gay people and empty-nesters should consider taking in a child
The County of San Diego is to ease its adoption procedures, making it easier for single people and same-sex couples to adopt.
This week's announcement came following an evaluation of the county's current adoption procedures requested by Supervisors Greg Cox and Dave Roberts.
'We're making an appeal to people to consider if they're empty-nesters, if they're non-traditional families, but they'd like to have adoptive children, that they consider adopting one of these really great kids that we have in San Diego county in our foster care system,' said Cox.
The Catholic Bishops of Northern Ireland say they can no longer support the agency now that it's 'legally obliged' to allow same-sex couples to adopt
The Catholic Church has announced that it is ending its relationship with an adoption service in Northern Ireland following changes in legislation that mean the service must accept applications from unmarried and same-sex couples as potential adoptive parents.
The agency in question is The Family Care Society NI. The agency was originally founded by the Church and has offices in Belfast.
Unlike other parts of Australia, South Australia does not allow same-sex couples or single people to adopt. Its government is now seeking the public's views on whether to change its adoption policies
In July, the South Australia Government announced that it planned to begin a public consultation and review of its adoption laws.
Currently, South Australia does not allow either same-sex couples or single people to adopt.
This is in contrast to most other parts of Australia: New South Wales, ACT, Western Australia and Tasmania all allow adoption by gay couples and LGBT individuals, as well as same-sex step-parent adoption.
The Los Angeles couple and their kids will feature on the annual show that raises awareness around fostering and adoption
CBS show Home for the Holidays is an annual TV institution that aims to highlight the fact that there are some 400,000 kids in foster care in the US who could benefit from finding adoptive families.
Now in its 16th year, the 2014 show – which will air on 19 December – will again look at several families that include adopted children. For the first time in the show's history, a same-sex couple will head one of those families.
The couple in question are partners Rich Valenza, aged 55 and Jared Gee, 39, along with their kids, Zack and Emmary.
November is National Adoption Month in the US. Both the Family Equality Council and the Human Rights Campaign have launched initiatives to help prospective LGBTI parents to realize their dreams
Are you living in the US and considering adoption? If so, you're not alone.
According to a recent National Family Growth Survey, an estimated two million LGB adults are interested in building a family through adoption.
However, the process is not always a smooth one – or even possible – depending on where you reside.
Whereas California allows LGBT adoption, Nebraska prohibits fostering by two unrelated adults – a policy that activists say has been consistently enforced against same-sex couples.
The two women, who split after 16 years together, have been in a custody battle over the three children they co-parented
An appeals court in Alabama has overruled an earlier ruling that granted child visitation rights to a woman who parented three children with her former same-sex partner – deciding that the woman should never have been allowed to adopt the children in the first place.
The two women – identified only as E.L and V.L – were in a relationship together between 1995 and 2011.
Following artificial insemination treatment, E.L gave birth to a child in 2002, followed by twins in 2004.
Thinking about adoption? Children will always have questions about being adopted, and knowing how to respond with honest answers is essential. We asked Beth Friedberg of New York's Modern Family Center for advice
Beth Friedberg is the Associate Director of Parent Preparation and Education at the Modern Family Center at Spence-Chapin. The center provides services for parents of adopted children, adoptees, families formed through adoption, and families brought together through remarriage – including same-sex couples and LGBTI parents.
Mariah MacCarthy talks to GSN about her real-life performance tale, Baby Mama: One Woman's Quest to Give Her Child to Gay People
Most women will reflect on the day that they gave birth to their first child as one of the best and most amazing of their lives. Playwright and performer Mariah MacCarthy experienced more mixed feelings when she was taken into hospital to have her labor induced: primarily because she wasn't planning on taking her baby home with her.
'I knew right away that I was going to choose adoption', she says of the day in January 2012 when she discovered, unexpectedly, that she was pregnant.
For a same-sex couple in Merseyside, adoption provided the answer to their dreams of motherhood
When gay male couples think about starting a family, the options most usually explored are adoption, surrogacy or an arrangement with a willing female friend. When a female couple or single woman wants to have children, then sperm donation or IVF treatment are the methods often utilised. However, not all women want – or are able – to give birth to their own kids, and for them, fostering and adoption are a more likely route to family life.
After breakup, biological mother tried to prevent stepmother from having any further contact with child
A lesbian who helped raise the child of her former partner has won the right to seek visitation or custody after being kept from the child after a break up.
An appellate court in New Jersey issued the decision on Wednesday (6 August) which found that if it is in the best interests of the child, maintaining a strong relationship with a 'psychological parent.'
The male child's name or the names of the parents were not made public to protect the identity of the child.
Bid launched to ensure religiously-affiliated adoption agencies continue to receive US funding even if they refuse to deal with LGBT prospective parents
The Family Equality Council is the latest campaigning group to react with protest at the news that a US Federal Bill could create, what it calls, 'adoption discrimination'.
Jason Hanna and Joe Riggs are each the biological father of one twin
The first Father's Day for Jason Hanna and Joe Riggs was bittersweet because days earlier, a judge in Texas denied their request to have their names placed on the birth certificates of their newborn twins.
The twins, Lucas and Ethan, share an egg donor and were born to a surrogate mother a month ago. They are half brothers with Hanna the biological father of one and Riggs the biological father of the other.
So far, only the surrogate mother's name is on either birth certificate.
A Slovakian couple lost their appeal to stop a gay UK couple from adopting their two sons, they had argued it would psychologically damage them to have gay parents
A Slovakian couple have lost their battle to stop a British gay couple from adopting their two young sons.
The couple's two young sons, one and four, are to be adopted by a same-sex couple in Kent, to the horror of the parents.
The couple, who come from a Catholic Roma community, argued if their children cannot be raised by a gay couple because their culture condemns homosexuality and took their case to the High Court in London.
The 17-year-old birth father is being charged with neglect after the baby died in his custody
A baby has died after being taken away from a lesbian couple that were just days away from finalizing his adoption.
Heidi and Rachel McFarland, from Iowa, took four-month-old boy Gabriel home from the hospital in what they hoped would be the beginning of their happy family.
After the married couple helped cut the umbilical cord, they spent every waking moment with Gabriel until he was returned to his birth parents.
'It's like he knew instantly,' Rachel McFarland said. 'We were his mommas'.
Over 20 same-sex female couples rejoiced as a court formally recognized they could be named as parents to a child
Gay women across the Netherlands are celebrating after a major victory in adoption rights.
After a recent court ruling, it means gay women but not men can be legally parents of a child without going through a lengthy legal process.
The same rules do not apply to male couples because legal parentship rests with the mother and she cannot simply transfer it.
This victory comes after 13 years the Netherlands originally permitted adoption by same-sex couples.
More travel destinations are catering to the needs of gay and lesbian parents as same-sex families are becoming more normalized. Here are some things to consider prior to departure
Gay and lesbian parents may experience challenges other households do not, but a family is still a family, and families need to get away every once in a while.
Planning a trip abroad with your family is an awesome opportunity to show your kids something new, or refresh your view on local destinations.
But whether your child is a toddler or just about to turn 18, there are some precautions every rainbow family should consider before starting of a journey.
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Hotel Continental Altamira
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Continental Breakfast
- Drycleaning onsite
- Meeting rooms/conference facilities
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- Non-smoking hotel
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TripAdvisor Reviews Hotel Continental Altamira Caracas
Travel Blogs from Caracas
2. Whirlwind tour of Caracas
... had a balcony overlooking one of the parks. Very nice. Don�t get me wrong, it was a little rough round the edges, but very comfortable and clean.We then went back down for breakfast with Nelson where we braced ourselves for another barrage of info and we were not disappointed. Whilst we ate our dry toast and dry scrambled eggs we sorted out money (you have to change money privately and not get it out of the banks as ...
Fun, fun in the sun... (and the museums and parks)
... by the Science Museum, which wasn't my favorite. For whatever reason I wasn't in the mood to see science-y stuff in Caracas and I was very turned off by an exhibit showing numerous stuffed heads from endangered animals.
Afterwards, I spent a good hour or so at the beautiful "Parque de Caobos", walking amongst beautiful trees and sculptures. I even got to have a quick workout at the park open-air gym and just spent a ...
Who's says Caracas is dangerous???
I figured Sunday is just about a good time as any to update you on my status for Friday and Saturday in the exciting city of Caracas.
Anyway, Friday night was dinner in this surprisingly happening, trendy place. It was a recommendation from someone, but if I didn't hear Spanish being spoken, I would swear I was in LA. The restaurant was called LOLA, and when I first heard the name, of course the Barry Manilow song popped into my head....."her name ...
In and out of Caracas
... a bus to a nearby beach area, but the tourist info lady said it would be impossible. So instead we grabbed a taxi and sucked it up having to pay the 150 bolivars to get us to Macuto. It took about half an hour to arrive and by now it was late and I was wilted with hunger. Luckily, we had called ahead and confirmed a room in our hotel, so in no time we were heading out to find something to eat.
Macuto reminded me of Taganga in Colombia; it was a beach side ...
Caracas explored and time to move on
... on things, especially as my spanish is basic to say the least although I'm starting to get up to speed with the rapidity of people�s replies to my questions and if all else fails there is always a smile and they tend to break into English.
Hopefully my money will hold out until I can reach colombia and with any luck I'll be able to do another update once I get to my next destination.

subset: commoncrawl


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Le Dîner à San Francisco 2015
- Food & Drink
- San Francisco
Geek Speak - Hosted by Cloudant
Wednesday, September 18, 2013 from 6:00 PM to 8:00 PM (PDT)
Join us for the first event in a new monthly meetup series: Geek Speak. Cloudant, a resident of the Geekdom SF community by Rackspace, will be hosting these regular discussions focused on big data around mobile and web applications. The third Wednesday of each month, we'll highlight a different topic and feature guest speakers who have a tale to tell about how they have solved big data issues.
September Meetup - Mobile!
We'll be talking about synching mobile devices, the cloud, and the movement of data...and how it all adds up to the internet of things!
Guest Speakers:
Darren Schreiber, CEO, 2600hz
Darren is CEO and co-founder of 2600hz, providers of a telecom platform that enables all aspects of telephony ranging from SIP trunking to PBXs and lightweight application APIs. He brings over 17 years of experience developing multiple enterprise SaaS infrastructures, open source telephony systems and large scale IT services.
Mike Miler, Co-Founder & Chief Scientist, Cloudant
Mike cut his teeth solving petabyte-per-second problems at the Large Hadron Collider. He's also a research asst professor at the University of Washington.
IBM Cloudant provides developers of large or fast-growing Web and mobile applications with the world's first globally distributed "data layer as a service" for loading, storing, analyzing, and distributing application data. For more information, visit https://cloudant.com/
Join millions of people on Eventbrite.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Toll Free: 1-866-554-4328
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Panasonic strives to provide efficient, compact heating and cooling equipment for every application. From their diverse selection of low ambient mini splits to their unmatched selection of multi-zone cooling only mini split air conditioners, Panasonic's innovation has resulted in a catalog full of compelling, unique comfort solutions for any home.
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LUSH Jungle
286 reviews
54% would repurchase
Package Quality: 3.4
Price: $$$
Package Quality: 3.4
Price: $$$
INGREDIENTSCocoa Butter, Cetearyl Alcohol and Sodium Lauryl Sulfate, Propylene Glycol, Avocado Extract, Glyceryl Stearate, PEG-100 Stearate, Cetearyl Alcohol, Stearic Acid, Perfume, Soya Lecithin, Figs, Bananas, Passion Fruit, Kumquats, Kiwi Fruit, Cetrimonium Bromide, Ylang Ylang Oil, Vetivert Oil, Cypress Oil, Sandalwood Oil, Chlorophyll, Limonene, Linalool
on 5/18/2014 3:20:00 PM
Age: 19-24
Skin: Normal, Fair, Cool
Hair: Black, Straight, Coarse
Eyes: Brown
I love the scent, I love it I love it I LOVE IT <3 And the scs alson reason why I buy it again and again. It smells like fresh cut grass, reminds me of holidays. :)
It comes in a compact bar and Lush says, you should ru it all ober your hair and rince it out. But I use it different:
I first cut it into little pieces, then add boiling water to create a thick paste. Then I add another conditioner to make a thinner paste. Finally, I add some olive oil. This paste should be stored in the fridge, but is way easier to apply than the block and is more nourishing. :)
on 5/15/2014 10:41:00 PM
Age: 18 & Under
Skin: Other, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
This is the worst product I have ever used. You cannot lather this at all and it is impossible to use. It smelled absolutely horrible. My hair felt disastrous after using this and could not believe that they actually sell something so horrible.
on 4/29/2014 9:43:00 AM
Age: 18 & Under
Skin: Acne-prone, Fair-Medium, Not Sure
Hair: Brown, Wavy, Coarse
Eyes: Brown
Pros: . Hair is so much more manageable, soft and shiny now . Smells lovely . Hair has been more curly since I started using it,which I love . When my hair looks a bit dry, I gently rub the bar on it (when the bar's dry of course!), gently comb it through and the hair's nice and moisturised . Vegan . Packed with natural ingredients . Environmentally friendly . Not tested on animals . Lasts ages. I've had mine six weeks, and there's still over three quarters of it left! Cons: . Takes trial and error to find the right method . If not rinsed out properly can leave a couple of curls looking greasy
on 4/13/2014 1:31:00 PM
Age: 18 & Under
Skin: Sensitive, Fair, Neutral
Hair: Brunette, Straight, Fine
Eyes: Brown
Ok, so i'm just going to say how pleased I am with this product, it feels amazing, and smells awesome. i'm 13, so this is the perfect light conditioner for my young hair. but how do you use it? I was faced with this question when I first used it. But then, when I accidentally left it in a little puddle of water, I worked it out. I used the bit that turned white, rubbed it into my hands, and then placed it in my hair!! I love it and it lasts for (almost) ever!!
on 4/3/2014 7:05:00 AM
Age: 19-24
Skin: Combination, Medium, Not Sure
Hair: Brunette, Wavy, Fine
Eyes: Green
I am really really happy with this conditioner! I had been using lush's solid shampoos for a while but I would always stick with a drug store conditioner. I'm happy I decided to give it a try - it makes my hair extremely soft, visibly thicker and oh god, I looove the smell, it lasts for so long! I use this in combination with Lush's New Shampoo and I have been amazed by the results so far. Concerning the application, I like mixing a little chunk of it in a bit of hot water, but it works also in it's solid form, the only thing is that, as already mentioned, you cannot expect it to lather as well as "regular" conditioners, but you will definitely feel it once your hair is dry! Will definitely buy it again!
on 4/2/2014 1:44:00 PM
Age: 25-29
Skin: Acne-prone, Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
-Smells delicious—very earthy.
-Natural product.
-Hard to distribute through hair.
-Have to use a lot more product than the typical shampoo bar from LUSH.
-Price, considering how quickly you will need to replace.
Would consider repurchasing, but would probably try something new. I feel great about having a natural product in my hair, but it is very hard to coat the ends. I find that I have to take the bar and literally rub it on the ends of my hair in a downward motion, and then once coated, use my fingers to massage it through. It does not act like a typically conditioner in the sense that it doesn't make your hair feel super soft in the shower. Instead, you put it in, rinse it out, and then it will feel better after it dries. I am using this in conjunction with LUSH's Jumping Juniper shampoo bar and so far, so good, but I'm not sure that it's worth $10 since I've only used it twice and it's already significantly smaller than when I first used it.
on 2/5/2014 4:05:00 PM
Age: 25-29
Skin: Combination, Fair, Warm
Hair: Brunette, Wavy, Medium
Eyes: Hazel
I love this conditioner!
I was wary at first about using a solid conditioner, but I'm glad I did!
It's very small, and green, and I'm not exactly a huge fan of the scent, but it's nice enough, a bit earthy, and for how the product works I'm a-okay with it!
It's also quite affordable at about roughly $10/bar, it's a deal, because it lasts quite a long time.
Perhaps the most awkward thing about using the Jungle Solid Conditioner is the fact that when it's in your hair, you can't feel it like you can other conditioners.
A lot of the other conditioners I've used have had silicone in it, which gives the hair that slick feeling when you have it in. Jungle doesn't have any in it, so it feels completely different.
Using it can be a bit tricky! Here's what I do! I make sure my hair is completely wet, and then I take the bar, let it run under the hot water for a few seconds, then I smooth it all along the length of my hair, If I feel like I haven't gotten enough it, I'll rub the bar between my palms to get some product on it, then apply it to my hair, focusing on the ends and avoiding my scalp.
You won't be able to feel it, but trust me it's there! My hair feels soft and moisturized when it's dry, whether it was an air or a blow dry.
Now, this being said, because everyone has different hair types, this is not guaranteed to work for everyone. My hair is wavy, thick and tends to be a bit on the dry side, and it works wonderfully for me.
It's a great conditioner for traveling or if you're environmentally conscious. I gave this a 5/5 for packaging because there was none, and I consider no unnecessary packaging a great thing!
on 1/29/2014 12:09:00 AM
Age: 18 & Under
Skin: Combination, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
I really wanted to like this product but it didn't make my hair soft or anything :( but the smell stays on hair for a long time so that's a plus..
on 1/16/2014 11:33:00 AM
Age: 19-24
Skin: Combination, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Green
It's been awhile since I found a product I was this in love with. First off it smells amazing! Fruity with a hint of earthy if that makes sense. Not an overpowering scent. It was nervous because I saw some reviews online that said it smelled disgusting and since I'm strictly an online customer I couldn't smell it beforehand. Regardless it smells amazing in my opinion! It's a little tricky to get the hang of how to apply it. I know other people have boiled it down to make a cream/paste but I want to leave it a solid. I wet my hair and then ran the bar all over my head. You barely feel like you're getting any product but you don't need a lot. (At least I didn't) I had to wet the bar a few times under the water during the application process. Then I let it sit in for 3-5 minutes. Upon using it for the first time using it I was skeptical about the results. I thought because of how little product was coming off that it wouldn't moisturize enough. I was also worried that it would make my hair oily. Rinsed it out, didn't feel like anything special. Air dried my hair. It smelled amazing while my hair was drying, then faded when my hair was dry. Results: It moisturizers plenty! Not a lot so that your hair becomes greasy and not so little that your hair feels dry. Also adds shine! :) I was impressed with how light and soft it made my hair! I should probably add that my hair is thick and gets greasy fast! I used Jungle yesterday and woke up with hair that looked even better if that's possible! Usually on second day hair my hair is a greasy mess but nope it looks amazing still! I would go out in public without washing my hair again! Just in case anyone is curious I used LUSH New! solid shampoo with jungle. I will definitely buy this again!
on 12/26/2013 6:16:00 PM
Age: 18 & Under
Skin: Sensitive, Fair-Medium, Warm
Hair: Brunette, Curly, Medium
Eyes: Brown
I love the earthy, herbally smell this conditioner seals into my hair after I use it. The smell evolved with me, when I first smelt it I hate it and I regretted buying it but as I got used to it more I loved it. I like melting small chunks of it with boiling water before I use it and it provides a really fresh non greasy looking shine and makes my hair feel as if it's sealed off and nourished correctly. It lathers into a creamy/milky liquid if you use it from bar form which still works wonderfully if you have the time to rub the bar about for a bit but for praticality reasons I like to just melt it before hands& that also helps me distribute the product more evenly. I find this quite an intensive conditioner which is great for my daily heat abused 'do but I can also see this being good for thinner hair if less product is used an the bar is just stroked across the ends/lengths of the hair. Very happy with it and will continue to repurchase until I find a cheaper/ better alternative but after 9 months of constant use up to date I doubt that will happen.
Popular Conditioners


text:
Planetary science: Sink holes and dust jets on comet 67P
Nature 523, 7558 (2015). doi:10.1038/523042a
Authors: Paul Weissman
Analyses of images taken by the Rosetta spacecraft reveal the complex landscape of a comet in rich detail. Close-up views of the surface indicate that some dust jets are being emitted from active pits undergoing sublimation. See Letter p.63
Self-similar energetics in large clusters of galaxies
Nature 523, 7558 (2015). doi:10.1038/nature14552
Authors: Francesco Miniati & Andrey Beresnyak
Massive galaxy clusters are filled with a hot, turbulent and magnetized intra-cluster medium. Still forming under the action of gravitational instability, they grow in mass by accretion of supersonic flows. These flows partially dissipate into heat through a complex network of large-scale shocks, while residual transonic (near-sonic) flows create giant turbulent eddies and cascades. Turbulence heats the intra-cluster medium and also amplifies magnetic energy by way of dynamo action. However, the pattern regulating the transformation of gravitational energy into kinetic, thermal, turbulent and magnetic energies remains unknown. Here we report that the energy components of the intra-cluster medium are ordered according to a permanent hierarchy, in which the ratio of thermal to turbulent to magnetic energy densities remains virtually unaltered throughout the cluster's history, despite evolution of each individual component and the drive towards equipartition of the turbulent dynamo. This result revolves around the approximately constant efficiency of turbulence generation from the gravitational energy that is freed during mass accretion, revealed by our computational model of cosmological structure formation. The permanent character of this hierarchy reflects yet another type of self-similarity in cosmology, while its structure, consistent with current data, encodes information about the efficiency of turbulent heating and dynamo action.
Large heterogeneities in comet 67P as revealed by active pits from sinkhole collapse
Nature 523, 7558 (2015). doi:10.1038/nature14564
Authors: Jean-Baptiste Vincent, Dennis Bodewits, Sébastien Besse, Holger Sierks, Cesare Barbieri, Philippe Lamy, Rafael Rodrigo, Detlef Koschny, Hans Rickman, Horst Uwe Keller, Jessica Agarwal, Michael F. A'Hearn, Anne-Thérèse Auger, M. Antonella Barucci, Jean-Loup Bertaux, Ivano Bertini, Claire Capanna, Gabriele Cremonese, Vania Da Deppo, Björn Davidsson, Stefano Debei, Mariolino De Cecco, Mohamed Ramy El-Maarry, Francesca Ferri, Sonia Fornasier, Marco Fulle, Robert Gaskell, Lorenza Giacomini, Olivier Groussin, Aurélie Guilbert-Lepoutre, P. Gutierrez-Marques, Pedro J. Gutiérrez, Carsten Güttler, Nick Hoekzema, Sebastian Höfner, Stubbe F. Hviid, Wing-Huen Ip, Laurent Jorda, Jörg Knollenberg, Gabor Kovacs, Rainer Kramm, Ekkehard Kührt, Michael Küppers, Fiorangela La Forgia, Luisa M. Lara, Monica Lazzarin, Vicky Lee, Cédric Leyrat, Zhong-Yi Lin, Josè J. Lopez Moreno, Stephen Lowry, Sara Magrin, Lucie Maquet, Simone Marchi, Francesco Marzari, Matteo Massironi, Harald Michalik, Richard Moissl, Stefano Mottola, Giampiero Naletto, Nilda Oklay, Maurizio Pajola, Frank Preusker, Frank Scholten, Nicolas Thomas, Imre Toth & Cecilia Tubiana
Pits have been observed on many cometary nuclei mapped by spacecraft. It has been argued that cometary pits are a signature of endogenic activity, rather than impact craters such as those on planetary and asteroid surfaces. Impact experiments and models cannot reproduce the shapes of most of the observed cometary pits, and the predicted collision rates imply that few of the pits are related to impacts. Alternative mechanisms like explosive activity have been suggested, but the driving process remains unknown. Here we report that pits on comet 67P/Churyumov–Gerasimenko are active, and probably created by a sinkhole process, possibly accompanied by outbursts. We argue that after formation, pits expand slowly in diameter, owing to sublimation-driven retreat of the walls. Therefore, pits characterize how eroded the surface is: a fresh cometary surface will have a ragged structure with many pits, while an evolved surface will look smoother. The size and spatial distribution of pits imply that large heterogeneities exist in the physical, structural or compositional properties of the first few hundred metres below the current nucleus surface.
Astronomy: 'Tatooines' may be common
Nature 523, 7558 (2015). doi:10.1038/523009d
Planets orbiting a binary star system — like Tatooine, the fictional home planet of Luke Skywalker in Star Wars — could form with surprising ease.Most known circumbinary planets orbit close to their stars, where the competing gravitational forces from the two stars make
Astronomy: Bounty of dark galaxies found
Nature 523, 7558 (2015). doi:10.1038/523009b
Astronomers have discovered more than 850 faint galaxies in a galaxy cluster that could be made mostly of dark matter.Using archived images from the Subaru Telescope in Hawaii, a team led by Jin Koda at Stony Brook University in New York searched for observations
Extra-terrestrials that resemble humans should have evolved on other, Earth-like planets, making it increasingly paradoxical that we still appear to be alone in the universe, the author of a new study on convergent evolution has claimed.
The argument is one of several that emerge from The Runes Of Evolution, a new book in which the leading evolutionary biologist, Professor Simon Conway Morris, makes the case for a ubiquitous "map of life" that governs the way in which all living things develop.
It builds on the established principle of convergent evolution, a widely-supported theory – although one still disputed by some biologists – that different species will independently evolve similar features.
Conway Morris argues that convergence is not just common, but everywhere, and that it has governed every aspect of life's development on Earth. Proteins, eyes, limbs, intelligence, tool-making – even our capacity to experience orgasms – are, he argues, inevitable once life emerges.
The book claims that evolution is therefore far from random, but a predictable process that operates according to a fairly rigid set of rules.
If that is the case, then it follows that life similar to that on Earth would also develop in the right conditions on other, equivalent planets. Given the growing number of Earth-like planets of which astronomers are now aware, it is increasingly extraordinary that aliens that look and behave something like us have not been found, he suggests.
"Convergence is one of the best arguments for Darwinian adaptation, but its sheer ubiquity has not been appreciated," Professor Conway Morris, who is a Fellow at St John's College, University of Cambridge, said.
"Often, research into convergence is accompanied by exclamations of surprise, describing it as uncanny, remarkable and astonishing. In fact it is everywhere, and that is a remarkable indication that evolution is far from a random process. And if the outcomes of evolution are at least broadly predictable, then what applies on Earth will apply across the Milky Way, and beyond."
Professor Conway Morris has previously raised the prospect that alien life, if out there, would resemble earthlings – with limbs, heads, and bodies – notably at a Royal Society Conference in London in 2010. His new book goes even further, however, adding that any Earth-like planet should also evolve thunniform predators (like sharks), pitcher plants, mangroves, and mushrooms, among many other things.
Limbs, brains and intelligence would, similarly, be "almost guaranteed". The traits of human-like intelligence have evolved in other species – the octopus and some birds, for example, both exhibit social playfulness – and this, the book suggests, indicates that intelligence is an inevitable consequence of evolution that would characterise extraterrestrials as well.
Underpinning this is Conway Morris' claim that convergence is demonstrable at every major stepping stone in evolutionary history, from early cells, through to the emergence of tissues, sensory systems, limbs, and the ability to make and use tools.
The theory, in essence, is that different species will evolve similar solutions to problems via different paths. A commonly-cited example is the octopus, which has evolved a camera eye that is closely similar to that of humans, although distinctive in important ways that reflect its own history. Although octopi and humans have a common ancestor, possibly a slug-like creature, this lived 550 million years ago and lacked numerous complex features that the two now share. The camera eye of each must therefore have evolved independently.
Conway Morris argues that this process provides an underlying evolutionary framework that defines all life, and leads to innumerable surprises in the natural world. The book cites examples such as collagen, the protein found in connective tissue, which has emerged independently in both fungi and bacteria; or the fact that fruit flies seem to get drunk in the same manner as humans. So too the capacity for disgust in humans – a hard-wired instinct helping us avoid infection and disease – is also exhibited by leaf-cutter ants.
The study also identifies many less obvious evolutionary "analogues", where species have evolved certain properties and characteristics that do not appear to be alike, but are actually very similar. For example, "woodpeckerlike habits" are seen in lemurs and extinct marsupials, while the mechanics of an octopus' tentacles are far closer to those of a human arm than we might expect, and even their suckers can operate rather like hands.
Conway Morris contends that all life navigates across this evolutionary map, the basis of what he describes as a "predictive biology". "Biology travels through history," he writes, "but ends up at much the same destination".
This, however, raises fascinating and problematic questions about the possibility of life occurring on other planets. "The number of Earth-like planets seems to be far greater than was thought possible even a few years ago," Conway Morris said. "That doesn't necessarily mean that they have life, because we don't necessarily understand how life originates. The consensus offered by convergence, however, is that life is going to evolve wherever it can."
"I would argue that in any habitable zone that doesn't boil or freeze, intelligent life is going to emerge, because intelligence is convergent. One can say with reasonable confidence that the likelihood of something analogous to a human evolving is really pretty high. And given the number of potential planets that we now have good reason to think exist, even if the dice only come up the right way every one in 100 throws, that still leads to a very large number of intelligences scattered around, that are likely to be similar to us."
If this is so, as the book suggests in its introduction, then it makes Enrico Fermi's famous paradox – why, if aliens exist, we have not yet been contacted – even more perplexing. "The almost-certainty of ET being out there means that something does not add up, and badly," Conway Morris said. "We should not be alone, but we are."
The Runes Of Evolution was six years in the making and draws on thousands of academic sources, and throws up numerous other, surprising findings as well. Sabre-teeth, for example, turn out to be convergent, and Conway Morris explains why it is that the clouded leopard of Asia, Neofelis nebulosa, has developed features that could, as it evolves "presage the emergence of a new sabre-tooth", although sadly it looks set to become extinct before this happens. Elsewhere, the study suggests that certain prehistoric creatures other than bats and birds may have attempted to evolve flight.
"It makes people slightly uneasy that evolution can end up reaching the same solutions to questions about how to catch something, how to digest something, and how to work," Conway Morris added. "But while the number of possibilities in evolution in principle is more than astronomical, the number that actually work is an infinitesimally smaller fraction."
The Runes Of Evolution, by Simon Conway Morris, is published by Templeton PressInset images:
The author of a new study of evolutionary convergence argues that the development of life on Earth is predictable, meaning that similar organisms should therefore have appeared on other, Earth-like planets by now.The almost-certainty of ET being out there means that something does not add up, and badly. We should not be alone, but we are.Simon Conway MorrisAlbert Kok, via Flickr. Homepage image: Eye of the Octopus by Klaus StiefelThe camera eye of an octopus is structurally similar to that of a human, but has evolved independently, making it a classic example of convergent evolution.
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Karl Paulsen (CPBE) is a SMPTE Fellow and chief technologist at Diversified Systems. Read more about other storage topics in his latest book "Moving Media Storage Technologies". Contact Karl at email@example.com.
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Kentucky holds off Kansas for John Calipari's first national championship
NEW ORLEANS – College basketball's best team during the 2011-12 season is also its national champion. And yes, that's actually saying something, because it doesn't happen very often.
The Kentucky Wildcats, ranked No. 1 in the country for 20 of 29 weeks this season, survived a nearly miraculous comeback by the Kansas Jayhawks to win the school's eighth national title.
Set up as a showdown between two of college basketball most storied programs, this title game was more of a coronation for Kentucky – for 38 minutes anyway. Holding a double-digit lead for most of the contest, Kentucky nearly fell victim to yet another Kansas comeback. The Jayhawks, down by as many as 18, rallied to within five with 1:37 to go.
At that moment, there was little doubt Kentucky head coach John Calipari, who'd never won a national championship, started having flashbacks to the 2008 title game when his Memphis team blew a nine-point lead with less than three minutes to go against … Kansas.
There would be no choke this time, however. Gilchrist blocked a Tyshawn Taylor shot that would have made it a one-possession game, then the Wildcats made four free throws in the closing minutes to hang on for a 67-59 victory.
For just the second time in 10 years, the No. 1 overall seed won it all. Kansas fans might not agree, but the best team of 2012 stood on the stage celebrating in front of 70,913 inside the Superdome.
"This is not about me, this is about these 13 players," Calipari said. "This is about the Big Blue Nation. But I don't know of any team that has sacrificed for each other like this team and they deserve this moment, they really do."
How good is this Wildcats team? They won four of six games in this year's tournament by at least 12 points and none was closer than eight. Monday night, they built that 18-point first-half lead without Anthony Davis, the AP player of the year, scoring a single point.
[ Photos: Kentucky celebrates winning eighth national title ]
That should (but won't) silence the critics who claim Kentucky wins on individual talent alone – that it somehow has an unfair advantage because of Calipari's unapologetic recruitment of the so-called one-and-doners. Sure the Wildcats boast the most talent of any roster in the country – Davis and fellow freshman Michael Kidd-Gilchrist could potentially go 1-2 in this June's NBA draft – but as they showed Monday night, they win as a team.
At one point, Kansas coach Bill Self squatted on the sidelines of the raised court inside the Superdome and shook his head. What else could he do? Break it down however you want, but sometimes the other team is just better.
"They're good," Self said. "The kids tried really hard. I'm so proud of them. They represented their school and themselves in such a first-class manner, but tonight we just weren't the better team. They were obviously the better team."
[ Dan Wetzel: John Calipari built program that's destined for more ]
Knowing he wasn't on his offensive game, Davis made his impact in other ways, grabbing 16 rebounds, blocking six shots, dishing out five assists and snagging three steals. In one sequence early in the first half, Davis stole an attempted alley-oop, pushed the ball up the court where Gilchrist got a put-back jam, then blocked a shot that led to another fast-break bucket.
Despite scoring just six points in the title game, Davis was named the tournament's most outstanding player.
"It's not hard to take a backseat, especially when playing with a great group of guys," Davis said. "I knew I was struggling. So I told them, 'I'm going to defend and rebound, you all make the points.' That's what they did tonight."
Doron Lamb and Marquis Teague picked up the offensive slack with 22 and 14 points, respectively.
"We were trying to get out of this gym alive," Calipari said. "But you've got to give Kansas credit, they didn't stop like they have all this tournament. They played well, but I'm so proud of these young men."
More NCAA tournament coverage on the Yahoo! network:
• Pat Forde: Stars playing without ego help Kentucky set a new standard for dominance
• Video: Kentucky fans party in New Orleans | Riots in Kentucky
• Kansas left shattered after comeback bid falls short | Photos
• Video: The Fray's dreadful national anthem performance | The Fray on Y! Music


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Gunmetal Black Ep 01
episode 14.26 / 5.00 5,045 Views
Lucina's First Day
A look at the first day of Lucina in Super Smash4.23 / 5.00 16,500 Views
BATMAN v SUPERMAN final showdown
SPOILERS!!4.19 / 5.00 14,725 Views
Hank likes, but that really does not deserve.
i love hank but he said bye so sad :(
he got rickrolled lol haha
wheres trickys mask
just read the summary tricky is the clowns name by the way
lol hank made a boo-boo.


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Slideshow: Saturday storms 6/20/15
Many viewers sent in photos of the storms that rolled through the QCA on Saturday
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Many viewers sent in photos of the storms that rolled through the QCA on Saturday
The Quad Cities Triathlon race got underway this morning at West Lake Park in Davenport.
A couple rounds of storms rolled through the area on Wednesday evening and sparked up high winds, heavy rains and intense lightning. Some KW…
Presidential hopefuls continue to announce their candidacy for the 2016 presidential election. Here is a breakdown of those of who officiall…
The Mississippi river flood of 1965 was, at the time, the worst flooding the Quad Cities area had ever seen. The river crested on April 28 a…
Several inches of snow blanketed the QCA Monday night into Tuesday morning, creating some beautiful photo ops. Email yours to email@example.com


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The DCRB Report is a newsletter that is mailed two or three times a year to all Plan participants. The Spring 2014 edition includes the Fiscal Year 2013 Investment Update, Statement of Net Assets, information on 2014 COLA Notices, and much more. All Plan participants should receive the Spring 2014 issue of the DCRB Report by mail, and active and retired participants who have email addresses on file should also receive an electronic version of the newsletter at their District of Columbia or designated email address.
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Watch her strip down to the point of embarrassment, accidentally revealing her "nana," unaware of how much she was taking off.
The message was left for someone called "nana," applying for work in a factory.
Stern looks and mini-head shakes to nana when she brought it up during her Christmas visit.


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I should put out there i'm looking for women... not blokes.
"Being a geek is all about being honest about what you enjoy and not being afraid to demonstrate that affection. It means never having to play it cool about how mulch you like something. It's basically a license to proudly emote on a somewhat childish level rather than behave like a supposed adult. Being a geek is extremely liberating." ~ Simon Pegg
Hmmmm.... Let's see how I can set myself apart from the rest of the female folks on here.
I am a very shy nerd, once you get me going, I break out of my "shy shell".
When I'm not working, or doing courses, you can find me beading (making bracelets and earrings), listening to music, reading, taking long walks, or hanging out with friends. I have a very eclectic taste in music; it ranges from heavy punk to classical (yes, I like country music too and have a weakness/soft spot for One Direction. Don't like it? Deal with it :P). I love hockey (been off and on with it throughout my life), two of my favorite teams are the Boston Bruins and the Toronto Maple Leafs. I also like to watch a bit of baseball … Can you guess what teams? If you have guessed the Red Sox and Jays, you just won yourself a cookie :D. I have been told many times that it's impossible to like both Boston teams and both Toronto teams at the same time. Clearly I've proved those people wrong.
I can lip read (not 100%, but pretty darn close). I used to take sign language (and am thinking about taking it up again)
Traveling is something that I would love to do. Two places on the top of my list are Boston and Great Britain. I have been to Massachusetts when I was a kid, but seeing it again would be awesome. Some places I have visited to are: Quebec, New Brunswick, P.E.I, Nova Scotia, Maine, Vermont, New York (State), I'm dying to go to Newfoundland. I don't know if it's noticeable … I love going down east (yes… you read right. And NEVER correct and east coaster when they say "Down east")
I do love to watch TV and movies. I love to watch anything from horror – to romance and everything in between. If it's comedy, I'm normally watching British comedy. I have a fascination for period films/TV shows … usually set in the 1800s. If you want a list of shows I like, just ask.
As for reading; I like to read, but sometimes can't sit long enough to get through a book. So instead, I listen to audio-books. I love doing this while I bead, it allows me to get lost. My genres for books are about the same as the movies and TV shows.
Who am I looking for? Well, I'm not really picky. But I tend to like people who are of the same mind as me. I'm quite Liberal and very open minded. I seem to have a thing for tall people (though it doesn't matter how tall you are so long as you are a we get along, all is right with the world). I think that as long as you can get past the fact that I like One Direction…. We will be fine :P
I think that is enough for now, if you have more you want to know, just ask.


text: Study Search Results Your query returned 2 results. Results per page: 25 50 100 Sort by: Study Relevance Title A-Z Released/Updated Time Period Most Cited in ICPSR Bib. Variable Relevance (?) Study Title/Investigator 1. Evaluation of SAFEChildren, a Family-Focused Prevention Program in Chicago, Illinois, 2006-2010 (ICPSR 33101) Tolan, Patrick; Henry, David; Gorman-Smith, Deborah; et al. 2. Criminal Justice Drug Abuse Treatment Studies (CJ-DATS) 2: Organizational Process Improvement Intervention (OPII), 2010-2013 [United States] (ICPSR 35082) Prendergast, Michael; Shafer, Michael; Frisman, Linda; et al. [1]


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1971 Porsche 911T CoupeTo be OFFERED AT AUCTION at Auctions America's California event, July 17-18, 2015. Click here to view this listing on the... More
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1971 Volkswagen Super Beetle Convertible. This Super Beetle has received a complete professional restoration. The car was completely disassembled and all rust was removed... More
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1971 Chevelle SS 402 - Body off restoration. Real red car with saddle wood interior. Bucket seats, automatic transmission with floor shifter. Power Steering,... More
ONE-OWNER, LOW MILEAGE TIME CAPSULE. SEE VIDEO. Purchased new in San Jose in 1971 by the wife of a U.S. Ambassador. This 250 sedan was... More
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1971 Plymouth Cuda 340, Pistol Grip, 4 speed 8 3/4 3.91 Sure Grip performance axle, quick ratio power steering, front disc brakes matches this... More
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This extremely original, 1971 Chevrolet C-10 Cheyenne Pick Up comes to us from its third owner and it as resided in Texas, Oklahoma and... More
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1971 Toyota FJ40, Early 80's frame off resto-mod. Owned for last 25 years. Toyota 3 spd drive train w/350 chevy, power steering, hyd tilt... More


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Located a short walk from Lord Street, this elegant late Victorian house has been well appointed to provide thoughtfully furnished bedrooms with smart modern en suite bathrooms. Breakfast is served in...More about The Baytrees
Set in one hundred acres of rolling countryside, Ribby Hall is a tranquil and relaxing place to stay. The luxurious bedrooms are comfortable and come in a range of sizes. The spa is the focus of the p...More about The Spa Hotel at Ribby Hall Village
This popular family-run hotel is close to the town centre and the seafront. Bedrooms vary in size and style and include superior and club class rooms. Newer bedrooms are particularly elegant and taste...More about Bedford Hotel
High quality, budget accommodation ideal for both families and business travellers. Spacious, en suite bedrooms feature tea and coffee making facilities, and Freeview TV in most hotels. Internet acces...More about Premier Inn Preston Central
This attractive, well-maintained farmhouse, located in a quiet corner of the village yet close to the M6, dates back to the 18th century. The majority of bedrooms are located in a sympathetic barn con...More about Parr Hall Farm
This purpose-built hotel enjoys a convenient location, just off the M6, within easy reach of Preston and Blackpool. Spacious public areas include extensive conference and banqueting facilities as well...More about BEST WESTERN PREMIER Leyland Hotel


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TANZANIA: Diageo's EABL cleared for Serengeti Breweries stake - report
Diageo's East African Breweries Ltd has been cleared by Tanzania's competition watchdog to acquire control of Serengeti Breweries in the country, according to a report.
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Roasting mushrooms to concentrate their flavor and then adding a few flame-cooked ones gives this vegetarian gratin wonderful complexity. This is a good recipe to use for distinctively shaped and flavored mushrooms like chanterelles or oyster mushrooms as they will retain many of their unique characteristics, but any variety will work excellently.
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Modulation of HLA class I expression in multidrug-resistant human rhabdomyosarcoma cells.
ABSTRACT An abnormal HLA expression has been detected in some tumors including rhabdomyosarcoma (RMS). Classical cytotoxic treatment of these tumors, the most common childhood soft tissue malignancy, may induce multidrug resistance (MDR) associated with the expression of a 170-kDa membrane-associated glycoprotein (P-glycoprotein). In order to analyse the connection between modulation of HLA expression and the development of the MDR phenotype mediated by P-glycoprotein in RMS, we used three resistant RMS cell lines; two of these resistant cell lines (TE.32.7.DAC and RD-DAC) were established by in vitro exposure to actinomycin D, a drug of choice in the treatment of RMS; the resistant RMS- GR cell line was established from an embryonal RMS tumor after polychemotherapy. Our results showed that all the resistant cell lines showed a significant increase in the expression of HLA class I surface antigens in comparison to drug-sensitive cells. Blockade of P-glycoprotein with verapamil led to a decrease in HLA class I expression in RMS resistant cell lines. However, no modulation of HLA class II expression was observed in any of the three analyzed cell lines. These findings support the hypothesis that the development of resistance mediated by mdr 1/P-glycoprotein, directly influences the expression of HLA class I in RMS cells, inducing to upregulation. This effect may be relevant to the application in RMS of immunotherapy against tumor-associated antigens presented by HLA class I molecules.
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ABSTRACT: Despite dramatic advances in surgical techniques, imaging and adjuvant radiotherapy or chemotherapy, the prognosis for patients with malignant glial tumors remains dismal. Based on the current knowledge regarding immune responses in the healthy CNS and glioma-bearing hosts, this review discusses dendritic cell-based immunotherapeutic approaches for malignant gliomas and the relevance of recent clinical trials and their outcomes. It is now recognized that the CNS is not an immunologically tolerated site and clearance of arising glioma cells is a routine physiologic function of the normal, noncompromised immune system. To escape from immune surveillance, however, clinically apparent gliomas develop complex mechanisms that suppress tumoricidal immune responses. Although the use of dendritic cells for the treatment of glioma patients may be the most appropriate approach, an effective treatment paradigm for these tumors may eventually require the use of several types of treatment. Additionally, given the heterogeneity of this disease process and an immune-refractory tumor cell population, the series use of rational multiple modalities that target disparate tumor characteristics may be the most effective therapeutic strategy to treat malignant gliomas.Expert Review of Neurotherapeutics 08/2005; 5(4):497-508. DOI:10.1586/14737220.127.116.117 · 2.83 Impact Factor
Article: Mahaley Clinical Research Award: chemosensitization of glioma through dendritic cell vaccination.[Show abstract] [Hide abstract]
ABSTRACT: A major reason chemotherapy fails in cancer treatment is drug resistance. New targets against chemotherapy resistance have been developed with the identification of molecular pathways in drug resistance. These targets are proteins that are highly expressed in human gliomas and are known to be tumor antigens. The immune system produces specialized white blood cells called dendritic cells (DCs). DCs are the most potent antigen-presenting cell of the immune system. DCs have demonstrated the ability to stimulate antibodies and cell-mediated immune responses against tumor antigens. Immunotherapy has emerged as a novel treatment strategy for gliomas with tumor antigens serving as the driving force. Clinical immunotherapy trials for glioma patients using vaccinations made of tumor antigens combined with dendritic cells ex vivo have shown promising results. DC vaccinations may increase sensitivity to chemotherapy, as demonstrated by a significant increase in 2-year survival rates in patients with malignant gliomas who received chemotherapy after immunotherapy (51). The use of DC vaccinations to increase sensitivity of tumor cells to chemotherapy can be rationalized as a novel strategy. Hence, this review will focus on the recent advances in the identification of tumor-associated antigens in gliomas, as well as their biological function related to drug resistance. The current research status and the future direction of DC vaccines to treat glioma in animal models and clinical trials will also be discussed.Clinical neurosurgery 02/2006; 53:345-51.
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ABSTRACT: Drug resistance represents a major cause of chemotherapy failure in patients with cancer. The characterization of the molecular pathways involved in drug resistance has provided new targets to circumvent or reverse chemotherapy resistance. Many of these target proteins are often overexpressed in human glioma and have been identified as tumor antigens, which implicate the development of immunotherapy as a therapeutic strategy. Dendritic cells (DCs) are the most potent antigen-presenting cells of the immune system and have been demonstrated to stimulate antibody and cell-mediated immune responses against tumor-associated antigens. Ex vivo-generated and tumor antigen-loaded DCs have been successfully introduced to clinical vaccination protocols, which have proven to be feasible and effective in some glioma patients. Most importantly, immunotherapy followed by chemotherapy could significantly increase 2-year survival in malignant glioma patients, which obviously demonstrates that DC vaccination could increase the sensitivity of tumor cells to chemotherapy. This review focuses on recent advances in the identification of tumor-associated antigen in glioma, as well as novel insights into their biological function related to drug resistance. These insights may provide the rationale for a novel strategy of a DC cancer vaccine that sensitizes tumor cells to chemotherapy. In addition, the current research status and the future direction of a DC-based vaccine to treat glioma in animal models and clinical trials will also be discussed.Expert Review of Vaccines 05/2006; 5(2):233-47. DOI:10.1586/14760518.104.22.168 · 4.22 Impact Factor


text: Jimmy Fallon Tonight Show Debut by Hilton Hater at February 18, 2014 10:17 am. Comments Share Tweet Email Jimmy Fallon is officially the host of The Tonight Show. Relive his opening episode here. Edit Delete Follow Jimmy Fallon? Star: Jimmy Fallon Related Videos: Jimmy Fallon Videos Related Post: Jimmy Fallon Debuts as The Tonight Show Host: Grade Him! Uploaded by: Hilton Hater Uploaded: February 18, 2014 Duration: 85 seconds


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The cute stickers for the nails by Alfa K, Paris.
It was a compelling meeting yesterday at Galleria Carla Sozzani to launch the
Biennial of Foto/industria Bologna in October 2015 in Bologna
with Matteo Lepore, the city councillor for Economy and City promotion of Bologna,
Francesca Colombo, the director of Fondazione Mast,
Francois Hébel, the artistic director of Foto/Industria,
Urs Stahel, the curator of Photo Gallery Mast
and Mariella Criscuolo for the new PhotoArt Award of Fondazione Mast.
Two limited reditions floral sculptures by Giacomo Balla,
realized by Dino Gavina, Centro Duchamp.


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Welcome to The Palmyra - a private residence that offers you a UNIQUE hotel alternative! The Palmyra is ideal for... Plus d'info »
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For backpackers, families, and couples. It's that place you go when you want to get away. The place that leaves you... Plus d'info »
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Chalet Tio Juan is located in a small neighbourhood called Saigon. Here you find a nice mixture of local people,... Plus d'info »
This new hostel is located directly opposite the park has quickly become the best of Bocas Town! Coconut Hostel... Plus d'info »
Fans or A/C available in all rooms! Amenities: Free Wifi Full Service Kitchen 3 Full Bathrooms Outdoor... Plus d'info »
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On a beach lined with palm trees you will find Gran Kahuna Beach Hostel in Bocas del Toro. Now located on Carenero... Plus d'info »
Everything you need you will find it. A full kitchen, a spacious living area, hammocks... This is your home away... Plus d'info »
Best Hostels Chain in Panama, At our location in Bocas del toro, we have a Full equipped hostel, Restaurant and bar,... Plus d'info »
Rafael`s House is located in the heart of Bastimentos Town and has been part of Old Banks history for over 80 years Plus d'info »
If you like to be independent, we recommend staying at our hostel at our Spanish school in Bocas. We have 3 rooms... Plus d'info »


text: Radiation Flag By: closingcubez Channel: fucking-science (More by author: Most viewed, Newest, Most Thumbs) previous next random - Fav + Fav Comment please don't be buttmad over a repost if radioactive is bad, sent! it to " room without supper. Lat it think about what it has done. ... Recommend tagsx +1688 Views: 66654 Favorited: 116 Submitted: 03/17/2013 Share On Facebook Remove from favorites Add to favorites Unsubscribe from closingcubez Subscribe to closingcubez Subscribe to fucking-science Unsubscribe from fucking-science


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£450 pcm
2 bedroom flat to rent Linden Grove Court, Great AytonWell proportioned, nicely presented, self contained first floor flat. Conveniently located within walking distance of Great Ayton High Street and amenities. Available to let UNFURNISHED. Comprising Ground Floor Entrance, First Floor Hallway, Lounge with real flame gas fire, Dining Kitchen with fi... More details ›
£550 pcm
2 bedroom apartment to rent Frankfield Mews, Great Ayton*2 BEDROOM, GROUND FLOOR APARTMENT, ALLOCATED PARKING, GREAT AYTON, £550.00 PCM* More details ›
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Appears in 25 channels
Reviewed in The best Apps and Games - Daily Update
Unlike other music recognition programs you also get here the lyrics, in real time to the song! P.S.: Via an In-App purchase you can remove the advertising and update a Chromecast support! Also optimized for tablets and Android Wear!
Reviewed in HOLO UI:Best of Google Play Store
musiXmatch Lyrics Music Player is a deep dive into the world of song lyrics, with the largest and most exhaustive official catalog of synchronized lyrics.
Reviewed in D-Jinnz Nathan Apps
Best music player. I dunno why but with this app I'm able to sing all songs :p
Reviewed in Best A-Z Android Apps
Reviewed in Best Apps
Sehr schöner Musik Player. Kennt fast jeden songtext und ist schön zu bedienen. Besser als der Standard Player.
Musixmatch is the world's largest lyrics catalog, that lets you enjoy diverse music with synced lyrics.
It has been featured among the "Best Apps 2014" selection on Google Play Store.
It is a must have app for music lovers: • Listen to the songs in your music library with synced lyrics.
Discover the FloatingLyrics™ feature to enjoy synced lyrics while playing your favorite songs with Spotify, Play Music and any other music app.
• Search lyrics for any song you love:
Instantly get the lyrics you're looking for and play the song from Youtube or Spotify
Can't remember the song title? Simply type part of the lyrics to find the song.
• Identify lyrics for music playing around you:
With a simple tap you can magically identify the song and the lyrics from the Radio, TV or any other audio source.
Your favorite and identified lyrics will be stored in your personal profile, and can also be found on musixmatch.com under 'identified songs'.
musixmatch is also the app providing lyrics to a z lyrics
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★ Cast music and lyrics to your TV with Chromecast
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Like us on Facebook: http://www.facebook.com/musixmatch
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Smith Enterprise, Inc.
B-407529,B-407529.2,B-407529.3: Dec 28, 2012
Additional Materials:
- Full Report:
Ralph O. White
(202) 512-8278
(202) 512-4800
(202) 512-8278
Office of Public Affairs
(202) 512-4800
Smith Enterprise, Inc., of Tempe, Arizona, protests the exclusion of its proposal from the competitive range under request for proposals (RFP) No. N00164-12-R-JN34, issued by the Department of the Navy for research and development services relating to gun muzzle suppressor technology. Smith objects to the agency's relaxation of the delivery schedule after Smith was excluded from the competitive range, and the agency's evaluation of proposals.
We deny the protest.
Jun 30, 2015
- Precise Management, LLC--ReconsiderationB-410912.2
Jun 29, 2015
- Bode Aviation, Inc.B-411265
- Decisive Analytics CorporationB-410950.2,B-410950.3
Jun 26, 2015
- SageCare, Inc.B-411260
- Computer World Services Corporation; CompQSoftB-411216,B-411216.3,B-411216.4,B-411216.5
- WKF Friedman EnterprisesB-411208
Jun 25, 2015
- K-MAR Industries, Inc.B-411262,B-411262.2
Looking for more? Browse all our products here


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Saturday, 25 February 2012
I've gone and done it!
Well, after much deliberation I've finally gone and done it....I've changed the name of my blog and actually bought a domain name (don't worry Hubby it cost $7). So in about three days time you will be redirected to PRET-A-MUMMY! I've been thinking about a new name for some time, something that encapsulates me and my writing. I like Pret-A-Mummy for a few reasons: it suggests an interest in fashion, which I definitely have. I'm not really interested in London Fashion Week type stuff, more stuff that as a Mum I can wear, be comfortable in and look vaguely sophisticated (at a baby group). I also like the use of the word "Pret" - meaning ready. As Mums we always have to be ready - ready to mummy! I do everything at breakneck speed before the screaming begins...so being a ready mummy reduces the stress (and heartburn).
Another thing I'm really interested in is cooking for my family and friends. I will only cook things that take up to ten minutes to prepare as the aforementioned screaming prevents any longer. So part of being Pret-A-Mummy is being ready to cook, such an integral part of motherhood.
So there you have it - fashion, mummy stuff, and cooking! And all three combined.
Please come and support me as I emerge from my cocoon....I need a bit of hand holding!
Posted by Heather Mc at 09:29
humour, parenting, toddler, cookery Bargain Mummy and Baby, cooking, fashiom
3 comments:
Love it, well done ready to mummy! Nothing I cook takes 10 minutes so looking forward to reading your recipes.ReplyDelete
Glad you found a name you like :) I have just signed up to your email subscriptions firstname.lastname@example.com and it all seemed to work just fine x give me a shout if you would like any other help (although i'm not self hosted on my blog i have made and hosted websites for other things :) xReplyDelete
Thanks so much! Has anything come through to your inbox yet though apart from the verification thing?ReplyDelete
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Changes related to "Canadian Conference of Mennonite Brethren Churches"
This is a list of changes made recently to pages linked from a specified page (or to members of a specified category). Pages on your watchlist are bold.
2 July 2015
m 23:26 Voth, Henry H. (1918-1981) (diff; hist; +81) RichardThiessen


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Enter your unique Login and PIN Number to access the members area.
Trouble logging in? Please click here.
Have you got a question, a query, or just a general chat. Please feel free to contact us using the quick form below. We are always happy to help.
Thank you, and happy golfing!
Waterloo Road, Southport,
England, PR8 2LX
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Visitor Tee Times are now available to book On Line up to 31st March 2016. Individual Tee Times can be booked...
A Magic Mo-ment for Martin America's Mo Martin produced two of the finest shots of her life to storm through the...
Our Boys Junior Open will take place this year on Friday 31st July. Please find attached the 2015 Entry Form which needs to be...
Please find attached the application form for this year's Ladies Scratch Trophy 2015 which is being held on Friday 28th August. If you...


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A week after a terrorist attack in Tunisia, local superyacht businesses are reassuring yachters that security has been increased at Tunisian ports despite numerous cancellations.
An update on Greece's port operations and local conditions was issued today by maritime services provider Inchcape Shipping Services (ISS).
According to ISS,
Authorities at the Danish ports of Copenhagen, Kalundborg and Fredricia have granted permission for GAC EnvironHull's pioneering, diver-free, underwater HullWiper
The Coast Guard and a good Samaritan rescued 4 people after their 20-foot boat caught fire on the Grand River, Sunday.
A boat crew from Coast Guard Station
Taba, an Egyptian ferry, carrying passengers, cargo and trucks, sank in the Red Sea early on Sunday, according to state-owned news agency MENA.
The 6,600-gt
MBCA Kim Nirvana, a passenger boat carrying 189 people has capsized in the central Philippines, minutes after leaving port, the Philippine Red Cross and coast guard spokesman Cmdr.


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Venere.com is the perfect place to make all of your hotel bookings in Everglades City, Florida! Check out our 10 Everglades City hotels, including a wide selection of accommodations, ranging from the super luxurious 5-star to the budget-conscious 2- and 1-star. Get the best value for your money with Venere. No matter what kind of accommodations you are looking for - ski, family, spa, sports, business, wellness, city center, adventure, golf or boutique hotels - we have the perfect hotel for your next vacation or business trip. Not sure which type of Everglades City hotel you want? Browse the 10 hotels on our interactive map to see exactly where they are located in Florida. Carefully read the detailed hotel descriptions for even more information on the Everglades City area and the hotel you are interested in booking. Find out about the nearby tourist attractions, such as museums, beaches, shops, monuments, churches and exhibition centres. Learn all you need to know about each of the 10 accommodations offered at Venere. Even find hotels with onsite restaurants, pools, gyms, internet, concierge and business services. When traveling to Everglades City, Florida - for work or pleasure, a quick weekend or an extended stay - check out Venere.com first. Venere has something to fit any budget. Get amazing discounts on Everglades City hotels. We update our inventory daily and are always adding new deals and sales for our 10 accommodations. Treat your special someone to a romantic weekend or book a fun-filled vacation for the entire family. Start by searching our easy-to-navigate website. Simply type Everglades City into the search box, then put in your travel dates and the number of rooms you need. Then simply look through all of the available accommodations among the 10 that Venere has to offer. Browse through all of the Everglades City hotels in the list and choose the ones that look good. Our gallery of photos will let you see what the hotel looks like inside and out. Read hotel descriptions for an overview of the hotel you chose in Florida. Be sure to check for any available freebies, such as free Wi-Fi, breakfast and parking! Get all of the information about your room and location before making your final choice. Check out the hotel reviews from genuine Venere guests and Tripadvisor comments to see what others have to say about your Everglades City, Florida accommodations. Learn all you can about your hotel choice and them book the perfect vacation accommodations with Venere.
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Outdoor Resorts of Chokoloskee
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Newton County will step up to save the Covington branch of the library, commissioners said Tuesday, but not before making one last attempt to get the city of Covington to contribute to the library's costly new heating, air conditioning and ventilation system (HVAC).
The Newton County Board of Commissioners voted to hire a new interim county manager Tuesday night, deliberately stopping short of placing the county chair in charge of the day to day administration of the county.
Hundreds flocked to Covington this weekend, and it was exactly the turnout Newton County Tourism President Jenny McDonald expected, but it was a little much for Newton County-Covington Chamber of Commerce President Ralph Staffins.
The students of First Baptist Academy zoomed around the parking lot of the Welcome Center last week to raise money for the parochial school's library and playground as part of the Academy's first bikathon.
Everyone living in Porterdale is a stakeholder in the promotion of the town's Main Street Program, says Josephine Kelly.
In his more than a decade and a half as Covington Police Chief, Stacey Cotton has led his men and women in the way he was taught to conduct himself by Judge Stacey W. Cotton and Suzanne Cotton - with ethics.
Covington Police Chief Stacey Cotton has been named one of 11 members named to Gov. Nathan Deal's new panel charged with making recommendations about what type of medical marijuana use Georgia should allow.
Newton Medical Center's Women's Diagnostic Center has recently been recognized as a Certified Quality Breast Center in the National Quality Measures for Breast Centers Program™. This distinguished honor represents a commitment by this breast center to provide the highest level of quality breast health care to patients in the community.
The Newton County School System's high schools will be celebrating graduation Friday and Saturday.
Teams of four golfers will play Ashton Hills Golf Course in Covington at the Drive4Hope Charity Golf Tournament on Thursday, May 21. The event is sponsored by Covington First Baptist Church and will raise money for the church's Haiti Mission Projects.
Walkers and runners will be raising money for the Damascus Road Recovery, Inc., a nonprofit long-term residential recovery program for men suffering from dependence on drugs and alcohol in Newton County.
The solid waste citizen's panel will explore all options, including closing the current landfill on Lower River Road, while emphasizing the need to reduce waste across the board, its members decided Thursday.
A 19-year-old Newton County man sustained fatal injuries in a single-vehicle accident at the intersection of Gum Creek Road and Ellis Road Tuesday afternoon.
Firefighters who responded to a call for medical assistance on Gum Creek Road Saturday were ambushed by a woman who leapt out of the bushes armed with a shovel and began chasing them while shouting threats such as "I'm going to kill you."
COLUMBIA, S.C. (AP) - Volvo Cars will build a $500 million plant - its first in the U.S. - in South Carolina and eventually employ up to 4,000 people there, the company announced Monday.
When Dr. Robert "Bob" Faulkner first began practicing medicine in Newton County 50 years ago, an office appointment cost $3. Waiting rooms were segregated by race. There were no mental health facilities, and delinquent children were subjected to the regular court system.
Newton County State Representatives Pam Dickerson and Dave Belton welcomed the passage of two pieces of legislation this week to crack down on potentially dangerous cyberbullying.
More than 300 agriculture students from high schools in Newton, Henry, Jasper and Butts counties had the chance to learn about potential careers in agriculture during the 3rd Annual Ag Career & College Expo held March 17 at the FFA Camp in Covington. The event, organized by the Newton County Farm Bureau, gave students the chance to meet with representatives of 12 colleges and representatives of 16 agribusinesses in Newton and surrounding counties.
The Covington City Council spent a full day of work at the Carl Vinson Institute of Government in Athens during its 2015 retreat Tuesday, hashing through several issues for the city going forward.
Oxford's City Maintenance Facility was named the Thomas Turner Building during a ceremony in Oxford Friday.
Camden Wyman received a proclamation Friday after his work on the old Porterdale city jail. As part of his Eagle Scout project with troop 93, Wyman treated the roof, pressure washed, painted and landscaped the old jail.
The city of Social Circle held its Egg-stravaganza Saturday, celebrating the Easter weekend. The free community event held at Social Circle Elementary School hosted egg hunts for children up to 12 years old.
Springhill resident Sierra Benton has declined to serve on the landfill citizens' committee. She will be replaced by Sharon Sawyer.
A smash-and-grab robber who has been hitting businesses in Rockdale and Newton counties since March 23 has been caught, thanks to the quick action of a Rockdale County Sheriff's Office deputy.
The Covington City Council spent a full day of work at the Carl Vinson Institute of Government in Athens during its 2015 retreat Tuesday.
The county's controversial legal spending was the elephant in the room Tuesday as a joint citizen-county committee met for a second time to discuss tightening the county's purchasing policy.
The Eastside High School Academic team won the Division 4 state championship after cruising through the competition at the Georgia Academic Team Association (GATA) State Championship Tournament held at Collins Hill High School on March 21.
The closing paragraph of General Douglas MacArthur's April 19, 1951 address to Congress: "I still remember the refrain of one of the most popular barracks ballads of the day which proclaimed most proudly that old soldiers never die; they just fade away. And like the old soldier in the ballad, I now close my military career and just fade away, an old soldier who tried to do his duty as God gave him the light to see that duty."
An open meeting Monday night generated a few suggestions and more than a few questions over the future of the county landfill, as the citizen panel to study the issue was finalized.
Over 600 volunteers turned out Saturday for the start of the Great American Cleanup, which will continue from March until May.
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Top Definition
Wiping Margott is the act of wiping from the front after taking a crap, rather then from behind. It is an awkward and messy approach but preferred by many.
"what's that stain on your sleeve?"
"oh, I was wiping margott and slipped"
"oh, I was wiping margott and slipped"
by Sammy Gooch October 05, 2011


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Temple's Skipper Bivins and Trent Jackson are noodling's new stars
Big Fish Adventures caught the attention of Half Yard Productions, which pitched an idea for a weekly television show.
Animal Planet liked the pilot, and filming for the weekly series began in May in southwest Oklahoma. Twelve episodes are scheduled beginning Aug. 7.
Most of the rookie noodlers Bivins escorts through the muddy waters of southwest Oklahoma on Hillbilly Handfishin' have rarely been off concrete.
"I eventually coax them into being the bait," Bivins said. "City slickers make danged good bait."
Bivins' favorite episode features a young Chicago photographer who met a very aggressive 30-pound blue catfish on his adventure in Oklahoma.
"It bit him about a dozen times, over and over and over," Bivins said. "He was just screaming. He just kept on. I thought his eye was going to pop out, and I was going to have to catch it.
"He got the experience of a lifetime for sure. He got into a freshwater shark attack. He may have gotten some pedicures before but not like this."
All of the noodling occurs in a 100-mile radius of Cotton County, Bivins said.
Many landowners in Cotton, Jefferson and Love counties were generous enough to allow Bivins and his film crew access to lakes, ponds, rivers and creeks on their land.
These two Cotton County noodlers seem to be naturals on camera.
"Jackson and I have been cutting up with each other all of our lives," Bivins said. "We are just being ourselves and having fun and showing the guests a good time. I guess that comes across."
"Hillbilly Handfishin'"
What: New television show featuring noodling in Oklahoma
When: Sunday nights at 9 p.m. beginning Aug. 7
Where: On Animal Planet


text: Kzen is a decorated asian food restaurant, located in the main area of Goya. They have a lot of options on the menu and the food is very good and fresh. Staff is very friendly and efficient. They also speak proper Spanish, instead of most of the chinese restaurants around Madrid. It is not very... read more