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"HEARING MATES" SOUTH HAMPSHIRE BRANCH "Hearing Mates" Secretary, Barbara Pink, 18 Wessex Park, Sutton Scotney, Autumn 2009 Issue Fifteen Winchester, Hants, SO21 3LB Telephone: 01962 760395 - Email: firstname.lastname@example.com Hearing Dogs South Hants Branch website: www.hearing-dogs-southhants.org.uk for Deaf People The South Hampshire Branch of Hearing Dogs for Deaf People is always looking for volunteers to help raise funds, become Puppy Greetings to Everyone from the Chair. Socialisers, fundraisers or sponsors for any of the dog training needs Summer sun may have been in rather short supply this year but it has listed on the charity website. not reduced our fund raising activities. Barbara and Chris each hosted very successful coffee mornings, and Angela had a fantastic If you feel able to help in any way connected with support for Open Garden. Everyone helped to make the Botley coffee morning a Hearing Dogs do please contact Secretary, Barbara Pink. Your help, great success and I am grateful to all the people who cleared the however small is always greatly appreciated by the Deaf or hard of garden of paraphernalia, it was great not to spend the afternoon hearing recipients of the dogs who are trained to help them. taking leftovers to the charity shops! Next Hearing Mates - Spring 2010 - please send your items no later than Our Gentle Giants Steve and Yogi are due in Monday 12 April 2010 London in October for "Rescue Dog of the Send to the editor Year" awards. We know that they will be in Ann Perrett, Auburn Lodge, Crampmoor Lane, Romsey, Hampshire SO51 9AJ the first three so Good Luck to Steve and Yogi TXD: 18002 01794 511812 - Fax: 07092089182 we will all be keeping our fingers crossed for a Email: email@example.com good result! Disclaimer - 'Hearing Mates' has been produced by the South Hants Fundraising Branch of Hearing Dogs, and the views expressed herein Gill is now relieved of the chore of taking all do not necessarily represent the views of the Charity. the used postage stamps to the Grange as Barbara can now send them direct to the buyer. The first sack netted Hearing Dogs for Deaf People is a charity that trains dogs to alert deaf £147 so do encourage your friends and families to save all their people to sounds such as the alarm clock, doorbell and smoke alarm. The stamps for us. (Details page 15) dogs alert by touching with a paw – then leading their owner back to the We haven't yet filled a cubic metre box with plastic milk bottle caps, sound. For sounds like the smoke alarm the dogs alert then lie down to it seemed to take forever to cover the base, but now each time I go to indicate danger. As well as practical help, hearing dogs give increased Moorland Farm the quantity has increased. If you don't know the confidence, security and independence. They are free of charge to the whereabouts of Moorland Farm give your tops to a committee deaf applicant. Whenever possible, the dogs are selected from rescue member who will pass them on. centres. They are also donated by breeders and members of the public, with the remainder coming from the Charity's own breeding scheme. N.B. Traces of milk must be washed from the tops and they must have a triangle with a '2' inside. The Grange . Wycombe Road . Saunderton, Please also note: caps from other products are not Hearing Dogs Princes Risborough . Buckinghamshire HP27 9NS. acceptable. Telephone: 01844 348100 - voice/text for Deaf People Fax: 01844 348101 Our daughter branch in West Sussex is up and running - they are Email: email@example.com Registered Charity Number 293358 http://www.hearingdogs.org.uk planning several Christmas events. Report from the Chair (continued) REGULAR FUNDRAISING ACTIVITIES Do hope lots of you will be able to support our new Christmas event - the Keep collecting used stamps Winchester Fair in December around the ice skating rink. Dianne will For used postage stamps ONLY send or take to: need lots of volunteers to fill the rota. Barbara Pink, Branch Secretary address back page, Chris Seward has been co-opted on to the committee. She has some or to any committee member. interesting fund raising ideas and is bursting with enthusiasm. If you Mark the envelope - USED STAMPS have an idea for fund raising we would love to hear about it. Put foreign stamps in a separate envelope Please do NOT include other correspondence / monies etc. Meanwhile enjoy St Luke's little summer - long may it last. Best Wishes PRINTER AND LASER TONER CARTRIDGES - but NOT EPSON Jeanette Collett Instead of throwing your used cartridges away in the general rubbish please keep them in their original boxes and either: Puppy Walks Give to a member of the committee who will see they are taken to The second Tuesday in October will be the last Headquarters or.. walk for this year in the Upper Hamble Country Contact Hearing Dogs on: 01844 348100 (voice and Minicom) or.. Park -10 00 am on the green in front of the Farm Contact: Reclaim-It - Telephone: 01635 876900 who will Entrance. Socialisers are welcome to take their pups provide free containers and collection. in to the farm to get closer to the animals from 9 a.m. By 10 November summer will officially be CHARITY FLOWERS DIRECT over and we'll meet at the later time of 10 30am in Ring: 0990 300 600 the Victoria Country Park, Netley for a walk that 15% of the retail price of every order goes to the participating can, if necessary be mainly on hard surface paths. We start from the car charity. To support Hearing Dogs quote HDD when ordering. park nearest to the tea room. Order online at: http://www.charityflowers.co.uk Visits to the animals are still possible on the 4th Tuesday of the month MILK BOTTLE TOPS - any colour but must have a '2' inside a recycle but please be out by 10a.m. when the school children arrive. triangle. Take to Moorland Farm or give your tops to a committee Supporters are welcome to join the walks and it doesn't matter if you member who will pass them on. haven't got a dog it is a good opportunity to get to know each other. 2 N.B. Traces of milk must be washed from the tops. Please also note: caps from other products are not acceptable. Paws for coffee in June at Sutton Scotney Firstly a huge thank you to everyone who helped at the coffee morning LOTTERY and to those who contributed their wonderful cakes, most of which I had Raise funds by playing the to try of course! Without all your help and contributions it would not Lottery Game or the Great Weather Lottery Game; simply complete the leaflet and send to the enclosed address or visit to play at: have been the success that I think it was. It was a lovely sunny day and www.hearingdogs.org.uk or www.theweatherlottery.com we had quite a good turnout, admittedly lots of socialisers (with pups - thank you!) but also local villagers and friends. Search the Internet with http://www.clicknow.org.uk/ Including sales from the stock, money from the soft toy game and the HearingDogs coffee morning itself, we raised £279.23p in the 2 hours. All down to And every time you search you will be raising money for your generosity and kindness, so many thanks once again! Hearing Dogs for Deaf People. Average use of CLICK NOW 2 Barbara generates around £50 per person per year. 15 "Baxter - The Tale of a Talking Dog" Hidden Treasure I gather that you would like my permission to promote Hearing Dogs for Deaf People was launched way back in 1982. We all Baxter's book in your next South Hants Branch Newsletter. know about Favour and Lady, but it must have been 1984 when the The answer is of course "Yes". 10th Hearing Dog Benjy was trained and placed with a young deaf lady, Not that "my" permission is needed as I was not the author - Jane Moss, right here in South Hampshire. Benjy really helped to Baxter wrote the book and I merely typed it for him. If you improve Jane's confidence and independence. Jane's Mother Anne was haven't read the book yet, you will find that Baxter was so impressed by the work that Benjy did that she enthused about it to all socialised by Margaret and George Conrad in Chandlers her friends and was soon in demand as an official speaker to all sorts of Ford and his early life in south Hants features quite heavily in the early chapters. groups. In addition to the funds raised by giving talks Anne hosted Baxter would therefore be extremely upset if I didn't give permission to your coffee mornings, collected bric-a-brac, made jam and sold everything at branch. Margaret did put an article in 'Hearing Mates' about a year ago about it saying she had seen a draft, so this is a follow up to that. the annual Stubbington Fair. All in addition to being regularly called on Just to note: There is an error in the press release shown online - Baxter has by HQ to act as an official representative. Jane's brother Nigel actually attended over 220 talks and not 60 as stated. We do about 60 talks a obtained sponsorship and support from the company that employed year, not including PR and training events! him, while his wife Linda and family friends Shirley Corner and Janet Clarke helped wherever necessary. For the past quarter of a century As I paid for the initial production run and donated the book and its copyright to Anne and her team have worked tirelessly and are now close to Hearing Dogs, every penny from the sales (not just profit or royalties) goes straight to the charity funds. We have already raised over £2,000 since the book accomplishing raising money for their 12th Hearing Dog. A fantastic was launched at the beginning of June, so I hope you do well with your sales as achievement by a remarkable lady! Thank you Anne for all that you well. have done for Hearing Dogs. You certainly deserve your retirement and we all wish you well and hope that you enjoy it. So what is it about South Hants that spawns all these authors? I believe Michael We in South Hampshire will continue the fund raising for this most Forester was also in your area when he started his book, and I understand that he worthwhile of charities. is donating the royalties from his sales to the charity, so Hearing Dogs is doing well from South Hants "old boys". Jeanette Collett Adam Wilson and Baxter (South Hants Former Pupil) Ann and Perry would like to add a personal Perry Baxter's book can be bought from http://www.hearingdogs.org.uk £9.99 +p&p appreciation and thanks to Anne and her late is a daughter, Jane for their sponsorship of Perry. Ann super "If It Wasn't for That dog! had 2 letters from Jane and we were going to meet little dog By Michael Forester and but sadly that was not to be. So a big thank you to worth This is the magical story of Hearing dog, Matt's first year Anne, your family and friends for raising all the every with Michael; the challenges and accomplishments of monies for Hearing Dogs. Ann and Perry Perrett penny! climbing the Hearing Dog learning curve; the profound changes Matt stimulated and the inestimable joy he confers magically on everyone who meets him. Dianne and Lyndon Hatfield thank But most of all it is the strange power of meaty treats to work miracles in doggie behaviour! everyone for their expressions of Assistance Michael's book can be bought at Hearing Dogs website for £8.99 +p&p also Dogs UK support and sympathy. from bookshops or online at Amazon. Just another example of the great circle of friendship we have found with Note: Both books can be bought from Dianne so that the branch would be Hearing Dogs. 14 credited with the monies. 01329 281862 or email: firstname.lastname@example.com 3 Help us try emergencySMS! This is a photo of my son Tommy, If you have a hearing loss or have difficulty talking, you might not be able which I took while sorting the to use a mobile phone to contact the latest milk bottle tops. I hope it will emergency services directly. inspire others to collect!! A pilot scheme that allows you to send a I am in the process of dishing out the text to the 999 UK emergency services has begun this month. We want as posters to local schools, doctors etc, to many people to register as possible – but only people who cannot manage voice calls. If the trial is successful it will be launched in 2010. spread the word around. Once registered, you will be able to use the service in emergencies during this pilot. Register from 14 September so you can use the service when I have now been on the waiting list for a hearing dog for 16 months. A needed. It will be an alternative to making a voice call to 999. trained dog will really help me with the household sounds and letting 1. REGISTER others know I am deaf. I got a glare from the queue in the Building Just text the word 'Register' to 999. Then follow the instructions you receive. society the other day, as a mother and child in a buggy had obviously Or register online at www.emergencysms.org.uk asked to me move, which I hadn't heard, and in exchange I got 'looks to 2. SEND SMS TO 999 IN AN EMERGENCY Please do not make mock calls – only use emergencySMS for REAL kill' from a number of people. Not nice, when all I did was failed to emergencies (see also "IMPORTANT" below). hear! Sue Churchyard. State: Who? Police, Fire and Rescue, Ambulance, or Coastguard? What? Briefly, what is the problem? Kennel club good Where? Exactly where is the problem? Give name of road & town if able. Plus more information such as a house number or landmarks. citizen bronze award 3. WHAT HAPPENS NEXT? winners The emergency service will either ask for more information or tell you that Congratulations to: help is on the way. Don't assume that your message has been received until the emergency service sends a message back. A 'delivery report' does Chris Voller & Nickel not mean your message has been received. It will take about 2 minutes before the first reply. No reply within 3 minutes? Janey Devine & Erin Please find other ways of getting help. Chris Seward & Tara IMPORTANT Sandra Lee & Owen Please do not make mock calls – only use emergencySMS for REAL emergencies. For example, if: Photo a person's life is at risk a crime is happening now Chris Voller & Nickel someone is injured or threatened receiving their award the person who is committing a crime is near there is a fire or people are trapped you need an ambulance urgently STAMPS COLLECTIONS: Many apologies to Harry Decker, who brought someone is in trouble on the shoreline or missing at sea. the most stamps to the Botley coffee morning but was overlooked in the rush to Remember, you will only be able to use it if you have registered with sort out prizes. We are very grateful to him for his regular large donations. emergencySMS first. This is a UK-wide service but cannot be used from Also many thanks to Sarah and everyone at Zurich International for their stamp abroad. The pilot started on 14 September 2009 and runs until the end of collections which bring in one or two boxfuls at regular monthly intervals; and November. to everyone, including those at Davis World Travel, who save stamps for us You can only use the service with the phone you have registered. 4 however many; they all add up. For more information and to register, visit the website 13 www.emergencysms.org.uk FLYING PUPPY! 'Paws for Coffee' on the Beach at Hill Head - 30th July 2009 My sister, Jo is in Devon on holiday, following on from our 2 weeks Thanks to the great generosity of local businesses, including Lee Book down there. She took her own puppy Poppy. (Not a Hearing dog Shop, Canine Plus, Solent Pet Supplies, Maximillian Wines, Leonard's puppy) The cottage we stayed in has 3 floors, the top floor having a and Jane Hug Jewellers - together with friends, neighbours and Hearing wonderful view of the Dartmouth golf and country club with the sea Dog supporters from across Hampshire - the amazing amount of £711 beyond on a good day. When Jo arrived, Poppy bounded in straight was raised in two hours! up to the top of the cottage, where my Dad had left the window open, so the fresh air could come in and Poppy went straight over to the The weather was kind to us window. and about 150 people, This was a lesson to learn for us. You assume all is ok on entering a including many deaf house etc, but its worth checking with the dog on the lead for safety recipients and their working for potential hazards such as open windows and doors. dogs - together with Hearing It is down to the dog handler to double check to avoid what could Dog puppies currently in have been a terrible accident. socialisation came along for coffee and cakes at the I couldn't stop thinking about what could of happened but Poppy is Rotary Wheel House, Hill now having a WONDERFUL holiday digging sandcastles! Head - and made it a fantastic morning. Sue Churchyard Dianne Duffield, who has recently appeared on the BBC 1 'One Show' with her Hearing Dog Joey, came along with her family and told us NOTICES about how Joey has made a difference to her life, which inspired us all 1. The PDSA is advising pet owners to be on their guard against Lyme to raise even more funds for Hearing Dogs. Disease. There has been a marked increase in the number of suspected Our local Hill Head Beat Officer, cases of this painful and disabling condition, which can affect humans and PC Jim Heath came along and was animals. It is carried by a tick and the symptoms include a rash, fever, a 'big' hit with everyone, lameness and fatigue. The advice is for people to cover up in woods and long grass and to see the Vet if your pet shows any unusual symptoms. especially Barb, who asked him if he was the 'strip o gram'. I 2. The Disability Rights Commission has changed its name to the suggested to his boss that he could Equalities and Rights Commission. do this next year and make Hearing Dogs lots of cash, which 3. A new booklet called the "Accessible Guide to Britain", a guide to tourist places which have facilities for disabled people (including those she thought was hilarious and is that are Assistance Dog friendly), has recently been published. It is free to going to mention it in his appraisal! Blue Badge holders for a limited time (quote M0254), otherwise it costs Many, many thanks to you all and we look forward to seeing you at £6.99 including p&p. The guide can be ordered on www.accessibleguide.co.uk or by calling 0800 953 7070 'Paws On the Beach' in 2010. Chris and Tim Seward Thanks to the Hertfordshire branch newsletter "Dog Eared" for drawing our South Hampshire Branch Website 12 attention to these items www.hearing-dogs-southhants.org.uk 5 TREASURER'S REPORT Some Puppies…. Over the past six months we have been able to contribute £ £17,500 to Head Office funds and it looks as though there Some puppies are keen and eager to please, will be a further £6,000 by the time you read this newsletter. Clever right from the start. With a final push towards Christmas, there is good reason to You know someone special is waiting for them suggest that we shall do even better this year than last, when And that helps when the time comes to part. we raised £28,000. So how is this achieved? Some puppies are harder to live with, They bark or they chew and won't rest, There are many of us who donate funds to the Branch and these add up to a There's a little relief when they bounce on their way, sizeable sum. Several retailers, vets and pubs allow us to leave tins on their But you know that you gave them your best. counters and their customers fill them with their small change. Organisations and companies run events that attract good returns for Hearing Dogs and a core Then once in a while there comes along one of our members devote time and energy to giving talks towards which donations Who steals more than your socks or your shoe, are made. We have relied upon these established ways of fund raising for a She makes off with your heart, wraps it up tight, number of years and it is only by the efforts of a relatively small group that they And won't give it back to you. continue and new ones are set up. Still you guide her through all her adventures, Try to teach her all she should know, This year there have been some Just love her, enjoy her, but its so very hard innovations, with parties and coffee To come to that last "Off you go". mornings arranged, from which significant income has been generated. The squirrels creep back to the garden, Sponsorship for various causes has been You fill up the holes that she's dug fruitful, especially when combined with And, hiding the corner that's just a bit frayed, Gift Aid which has brought us almost an Put back the favourite rug. extra £1,000. Waitrose have introduced But what's this – a message from Sarah, a community scheme and we have been Another young dog you might take? Tara receiving (or eating?) a large fortunate in persuading them to include So its back to the Grange as quick as you can cheque from Tom, the Manager of us at a number of their stores. Who said that you wanted a break?! Waitrose in Southsea You pick up the next precious bundle, Collections at Supermarkets and other large retailers and our almost weekly Waggy tail and a small anxious face. attendance at shows over the summer months have yielded much interest and Get ready to love all over again - attention from the general public and we have benefited greatly from their The best way to start filling that space. generosity. Details of these activities are elsewhere in this newsletter, but clearly their fulfilment places a heavy burden upon many of us. None of it Maureen Heasman could be achieved without such dedication and the more of us who contribute, Dinner Dance - Saturday 24th October however small and in whatever way, the better it is for our favourite charity, its Frimley Hall Hotel Camberley, Surrey dogs and those in need who benefit from it. Roy Stainton Tickets £45 or table of 10 for £420 Charity auction and Raffle plus special guest Contact Fiona Chapman on 07770 986463 or Thanks to all donors for their generosity and email@example.com All proceeds to to all the hard working volunteers 11 6 Hearing Dogs for Deaf People Puppy Socialising Visit to LIZZIE Labrador Mandy Wright With recipient Clamp Kiln Farm Livery at Newtown, Fareham GRACE Shih Tzu Julie Ward (1st ) With recipient HARVEY Poodle Maggie Rumble With recipient Around Easter, Lucy O'Brien's puppy class visited Clamp Kiln KATIE Cockerpoo/Llasa Apso Chris & Tim Seward In training Farm at Newtown, not very far MUMBO Goldendoodle Nicola Laws In training from our Training Hall at ROLY Flat-coat Retriever X Michelle Shewring (1st ) In training Shedfield Reading Room. Mick and Laura Meech run a DOODLE Standard Poodle X Samantha Hopwood withdrawn Livery Stables and they very GIGGSY Cavalier King Charles Maureen Heasman With recipient kindly agreed to let us visit to introduce some of the puppies to the OWEN Cockerpoo Sandra Lee In socialisation horses. As it was a beautiful spring morning, most of the horses were out NICKEL Working Cocker Spaniel Mandy Wright In socialisation in the fields but some were wearing their raincoats and looked a bit NUDGE Working Cocker Spaniel Nicky Page (1st) In socialisation strange - especially from a dog's perspective. The horses were quite curious and are used to dogs around the farm on a daily basis, so MILO Cockerpoo Selina Foster (1st) In socialisation obligingly came to the gate to meet us. Some of the MARCO Cockerpoo Louise Davies (1st) withdrawn pups however weren't quite so keen to meet them, QUARTZ Cockerpoo Nicola Waters In socialisation but with Lucy's help most of them made it to the gate QUILLA Cockerpoo Lucy Orr withdrawn eventually. Many thanks to Mick and Laura and we hope to visit OLLIE Cockerpoo M & G Conrad In socialisation again soon. ERIN Sprocker Janey Devine (1st) In socialisation Chris Seward RONNIE Cockerpoo Barbara Lidbury (1st) In socialisation Tara, Chris and Tim's puppy SOLO Lab/Golden Retriever Mary Jane McKechie In socialisation Thanks to Maureen Heasman for the photo of Tara. TOMMY Cockerpoo Cathy Plumb In socialisation TERRY Cockerpoo Maggie Rumble In socialisation Charlie, our 3-year-old Hearing Dog TARA Cockerpoo Chris & Tim Seward In socialisation stud, fathered two litters in August, one with a Cockerpoo called Hope. The TRUDY Cockerpoo Sara Yaxby (1st ) In socialisation four puppies are named Yasmin, ROCKY Cavalier King Charles M & G Conrad In socialisation Yarrow, Yala and the only male, Yogi. CARA Golden Retriever Pauline Dalton (1st ) In socialisation His first puppies, Phoenix and Phoebe, DAISY Spaniel X Julie Ward In socialisation Thanks to Fiona Daniels for the photo are still doing well in Socialising and HOLLY Labrador Lucy Orr In socialisation are now 10 months old, so we hope to hear soon whether they make it WINNIE Cockerpoo Sandra Lee In socialisation into training. Gill Hunt 8 9 Donations received since Spring 2009 Hearing Mates Giggsy (Gizzy) Waitrose Andover Warsash Pensioners We had a lovely visit to The Grange to see Gizzy at Waitrose Gosport Redbarn Primary School the end of August. He was very pleased to see us, Waitrose Leckford Ms Ingamells looking really well and very happy with Suzanne his Waitrose Southsea Hambledon Rainbows In Memory of Ruth Collyer ENT, South Hants Hospital trainer. He showed off his sound work and we took Friday Club Portsmouth St Matthews Tuesday Club him off for a short walk round the fields. Suzanne has D. Leggett Chandlers Ford Widows been taking him home with her throughout his M. Leggett Mr Bache training, so she will miss him a lot too! Mrs Donaldson Bee Gizzy will be his recipient's second Hearing Dog, her Lymington Fair Jeanette Collett first is in poor health now, so Gizzy will be doing all Simplyhealth Chris Hunt the running about and outings. His donor has been in Dibden Barbara Pink to see him too and was very proud and a bit tearful. Surrey Dog Club Ann Perrett She had him as a pet but was working and not able to give him enough time, Mr Pear Angela Barnes so its a really nice outcome for such a lively little dog. Latham Opticians Roy Stainton Wallops WI Jo Baverstock It was great to see Gizzy so happy and enthusiastic, so I managed to sniffle Beryl Bourton only a little bit, after we had left them! Maureen Heasman Remaining Fundraising, events & collections for 2009 B O Thursday 01 October Saturday 21 November: T Deaf World Exhibition, Charities Fair L Southampton Rose Bowl Westhill Park School, Titchfield E Y Sat / Sun 10/11 October: Thurs 3 / Fri 4 / Sat 5 December Collection The Range Christmas Tree Festival, C Gosport Fareham Methodist Church O Saturday 21 November: Sat/Sun 06/07 December F Romsey Charities Fair Winchester Christmas Market F Crosfield Hall, Romsey E E M Amy Hearing Dog O Amy R is sponsored by N the South I Hampshire N Branch G 10 7
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posts from the Entertainment forums
Sweet25Girl posted in Celebs:
Harry Stylesreply about 4 hours
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sorry but..Harry Styles all the way [s:sm3/1jw1] [s:sm3/1jw1]reply about 6 hours
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Pitch perfect 2reply about 10 hours
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lol my dad too but my mom keeps saying stop watching those cartoons. I HATE when parents call them those cartoonsreply about 12 hours

subset: commoncrawl


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The Toronto Blue Jays had a total of four first-round picks, including three in the compensation picks, and all four were used on right-handed pitchers.
The Blue Jays' first pick was Geogia Tech's Deck McGuire at 11, followed by California high schooler Aaron Sanchez (34), Texas high schooler Noah Syndergaard (38) and Asher Wojciechowski (41) from The Citadel.
-- C. Trent Rosecrans


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Written By Jen
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A church built 10th or 11th century.


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An apparatus and a corresponding method for the in-vivo radio-therapy of blood by irradiation of the blood within the blood vessel. The device includes a wire which has a straight section and small oppositely facing loops at each of its two ends. An active radioisotope-layer is deposited over the center portion of the straight section of the wire and this radioisotope-layer is sealingly covered with a coating-layer to prevent any leaking of the radioisotope into the blood. The wire is adapted for surgical implantation diagonally transverse a blood vessel in a manner so that the active radioisotope-layer lies fully within the blood vessel, while the end of the wire projects such that the two loops lie fully exterior to the blood vessel. Following the depositing of the radioisotope-layer and the coating-layer on the wire and sterilization of the wire, the device is surgically implanted diagonally transverse the blood vessel and is anchored in place with respect to the blood vessel by suturing through the loops.
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Description (OCR text may contain errors)
United States Patent [191 Culver et al.
[ METHOD AND APPARATUS FOR THE lN-VESSEL RADIATION TREATMENT OF BLOOD [75] Inventors: Gordon G. Culver, Klamath Falls, Oreg.; William F. Riemath, Pasco, Wash.
[73] Assignee: The United States of America as represented by the United States Atomic Energy Commission, Washington, DC.
[22] Filed: May 21, 1973 [21] Appl. No.: 362,613
[52] U.S. Cl. ..-128/l.2, 250/493 [51] Int. Cl A6ln 5/10 [58] Field of Search l28/l.l, 1.2, 2 A, 260,
[5 6] References Cited UNITED STATES PATENTS 1,823,239 9/1931 Cervi 128/12 1,954,868 4/1934 Failla et al. 128/12 2,153,889 4/1939 Hames l28/1.l 2,405,026 7/1946 Feoer et a1 250/493 2,546,759 3/1951 Lee et al 128/260 3,505,991 4/1970 Hellerstein et al l28/l.l
[111 3,811,426 [451 May21, 1974 Primary Examiner-William E. Kamm Attorney, Agent, or Firm-John A. Horan; Arthur A. Churm; Robert J. Fisher 5 7] ABSTRACT An apparatus and a corresponding method for the invivo radio-therapy of blood by irradiation of the blood within the blood vessel. The device includes a wire which has a straight section and small oppositely facing loops at each of its two ends. An active radioisotope-layer is deposited over the center portion of the straight section of the wire and this radioisotopelayer is sealingly covered with a coating-layer to prevent any leaking of the radioisotope into the blood. The wire is adapted for surgical implantation diagonally transverse a blood vessel in a manner so that the active radioisotope-layer lies fullywithin the blood vessel, while the end of the wire projects such that the two loops lie fully exterior to the blood vessel. Following the depositing of the radioisotope-layer and the coating-layer on the wire and sterilization of the wire, the device is surgically implanted diagonally transverse the blood vessel and is anchored in place with respect to the blood vessel by suturing through the loops.
7 Claims, 1 Drawing Figure METHOD AND APPARATUS FOR THE IN-VESSEL RADIATION TREATMENT OF BLOOD CONTRACTUAL ORIGIN OF THE INVENTION The invention described herein was made in the course of, or under, a contact with the UNITED STATES ATOMIC ENERGY COMMISSION.
BACKGROUND OF THE INVENTION The present invention relates to radiotherapy and radiation treatment of blood and is particularly concerned with the in-vivo radiation treatment of blood. Specifically, the present invention is concerned with the radiation treatment of blood within the blood vessel. Still more particularly, the present invention relates to a method and a device for implantating a radiation source within the blood vessel which reduces the amount of shielding required and hence the complexity of the device and simplifies surgical procedure.
Radiotherapy including radiation treatment of blood as a potential cure or control of various diseases is well known in the art, radiotherapy being extensively used in the treatment of various forms of cancer. In particular, radiotherapy as a treatment for the control of leukemia has been studied and undertaken in the past.
Suppression oflymphocyte levels in circulating blood following irradiation of the total body with low doses of ionizing radiation is well known. It has been demonstrated that irradiation of blood in an exterior loop (extracorporeal irradiation of blood) suppresses lymphocyte levels without damage to other body tissues. It has consequently been shown that extracorporeal irradiation of blood is an effective adjunct or alternative to drug therapy for treating some forms of leukemia.
Immune reactions initiated by lymphocytes are usually the ultimate reason for failure oforgan transplants. Current methods of suppressing these immune reactions include use of drug therapy, antilymphocyte antibodies, and irradiation. Typically, more than one of these approaches is used since there are problems associated with each.
Acceptance times of skin allografts have been extended by extracorporeal irradiation of blood and this technique has been evaluated for its applicability for immunosuppression-relative to renal allografts. Significant reduction in early rejection eposodes and a significantly higher frequency of six-month renal graft survival has been reported for extracorporeal irradiation of blood-treated groups.
Most treatments of both experimental animals and humans have been accomplished by shunting blood through large fixed equipment such as cobalt-60, cesium- I 37 or X-ray sources, thereby necessitating specialized facilities. With the relatively long treatment regimes required, this severely limits the numbers of patients who can receive treatment and requires the inconvenience and expense of hospitalization. A small, inexpensive. portable irradiator is needed for the above reasons and also to permit chronic exposures of patients prior to and subsequent to kidney transplants.
A small implantable irradiator which would permit direct in-vivo irradiation of the blood is also desirable. One such portable irradiator consists of a small tube of shielding material coated on the inside with a radioactive isotope which is further coated to prevent leakage into the blood system. Small sections of an artery or vein are surgically removed and this tube inserted in substitution therefor, the insertion being accomplished by suturing the blood vessel to small fiber tubes located on each end of the device. These devices then serve as a small section of the blood vessel.
Alternatives to these devices are desirable as the surgical procedures involved in inserting them as a substitution for a section of a blood vessel are complex arid these devices require shielding to prevent the undesirable radiation of surrounding tissues.
Therefore, it is an object of the present invention to provide a methodand an apparatus for radiotherapy of blood.
It is a'further object of the present invention to provide a method and apparatus for in-vivo irradiation of blood. I
An additional object of the present invention is to provide a method and apparatus for the irradiation treatment of blood within'the blood vessel itself.
Another object of the present invention is to provide a device which is less complex and requires less or no shielding and which can be implanted by simplified surgical procedures. I 7
Other objects and advantages of the present invention will become apparent upon readingthe following description and with particular reference to the specific embodiment described hereinbelow.
' and apparatus is provided for in-vivo radiotherapy of blood by irradiation of the blood within a blood vessel.
A layer from an active radioisotope is deposited on the center portion of a wire which includes a straight section and small oppositely facing loops at each of its two ends. A coating-layer is deposited over the active radioisotope-layer to sealingly cover the radioisotope and prevent leaking of the radioisotope into the blood. Following sterilization of the device, the device is implanted in a blood vessel by surgically inserting the wire diagonally transverse a blood vessel in a manner such that the active layer lies fully within the blood vessel while the ends project such that the two loops lie fully exterior to the blood vessel. The device is anchored in place with respect to the blood vessel by suturing to the blood vessel through the loops at the end of the wire.
BRIEF DESCRIPTION OF THE DRAWINGS' An understanding of the features and operation of the present invention can be obtained from a reading of the following description and with reference to the drawing which is a sectional view through a blood vessel showing the device partially in section implanted in accordance with the present invention.
DETAILED DESCRIPTION OF THE INVENTION Referring now to the drawing, there is shown a device in accordance with the-present invention implanted layer 18. A coating-layer coats the central portion of the straight section 12 and sealingly covers the radioisotope-layer 18 so as to prevent any leaking of the radioisotope from the device into the bloodstream.
The device is shown as implanted in a blood vessel 22. The device is adapted for implantation diagonally transverse blood vessel 22 and is implanted in a manner such that active layer 18 lies fully within blood vessel 22, i.e., active layer 18 lies within the interior 24 of the blood vessel 22 between the walls thereof. The device is further implanted such that the loops l4 and 16 at the two ends of the straight section 12 lie fully outside and exterior to the blood vessel 22. The device is anchored in place with respect to the blood vessel such as by sutures 26 and 28 through loops l4 and 16, respectively. The device is anchored in order to prevent the undesirable loss of the device in the body and to prevent undesirable movement relative to the blood vessel 22. i The active radioisotope-layer 18 can be deposited on the center portion of the wire in any manner known and practicedin the art including, amo'ngothers, elec-- troplating from a solution containing the radioisotope. Similarly, the coating-layer can be deposited over the active radioisotope-layer in various manners well known in the art including, among others, vacuum sputtering of a metal. Following depositing of the coating-layer and prior to implantation, the device must be sterilized, sterilization by gamma irradiation being one of the many possible methods which can be employed, The device is then implanted in a blood vessel by surgically inserting the device so as to lie diagonally transverse the blood vessel, as described hereinabove. While various means of surgical implantation can be used, two examples of surgical methods which have been found particularly adaptable to the present device are insertion through the blood vessel in a hypodermic needle followed by withdrawal of the hypodermic needle,
' leaving the device in place, and insertion of the device across theblood vessel through two surgical incisions in the wall of the blood vessel, the incisions being made on opposite sides of the blood vessel and diagonally spaced so as to accommodate the device diagonally thereacross. lf the'device is implanted by the latter method wherein incisions are made in the blood vessel wall, the sutures used to close the surgical incisions in the blood vessel can also be employed to anchor the device in place with respect to the blood vessel by making the sutures through the loops on the respective two ends of the straight section.
This device offers versatility in that the choice of the radioisotope to be used can be made based upon the desired intensity of radiation and the desired energy of radiation. Since the coating-layer can be made very thin as by vacuum sputtering a metal, it is possible to use either alpha emitters or beta emitters for the radioisotope. Since the device is inserted directly into the bloodstream and is surrounded by blood, extensive radiation shielding is not required, as the radiation emitted will be absorbed by the blood itself with no damage to surrounding tissues. This device permits surgical implantation by means of much simpler surgical procedures and is therefore far less traumatic than other known implantation procedures.
DESCRIPTION OF PARTICULAR EMBODIMENT While the invention is hereinafter described in connection with a particular specific embodiment, it will be understood that it is not intended to limit the invention to only that specific embodiment, but it is intended to cover all alternatives, modifications and equivalents as maybe included within the spirit and scope of the inventionas defined by the appended claims.
A device was constructed and implanted in accordance with the present invention. The device was formed of a Type 302 stainless steel spring wire 0.010 inch in diameter and just over 2 inches long. The wire was formed with opposing 0.040-inch-diameter loops at each end, the centers of the loops being 2 inches apart.
The wire was ultrasonically'cleaned in approximately 10 percent solution of Delex a commercial detergent and ultrasonically rinsed in distilled water twice, followed by a tripple rinse in reagent-grade acetone, and I used in the past for production of standard samples of,
other radioactive actinides,
The electroplating cell was filled with approximately 10 cc of dimethyl sulfoxide. A D-C power supply. was
connected to a platinum anode and the irradiator wire serving as a cathode with small alligator clips. A magnetic stirrer was adjusted to rotate the stirring bar such as to give good mixing without causing a noticeable vortex in the liquid. micrograms of dried "PuO was dissolved in 25 microliters of 6 N nitric acid and transferred to the cell. The power supply was adjusted so as to apply 3.5 volts across the cell and adjusted so that the current flow through the cell was 0. l milliamp. The current was applied and continued for 20 minutes. in order to prevent redissolution of some of the PuO,, the liquid was decanted with a syringe to below the level of the wire before reducing the voltage.
While the current, voltage and electrode spacing are probably not critical and are interdependent as in any cell, in order toobtain very smooth deposits, itis important to adjust the current flow and stirring speed to prevent the formation of bubbles on the wire. 0n previous attempts using higher voltage and current, a few bubbles were produced on the wire, resulting in deposits which appeared thicker to the naked eye and were black. On microscopic examination, these deposits were found to be rough with high peaks and with the appearance of a sponge. On such a deposit, a containment layer thick enough to assure a nonsmearable de- M time, the alpha radiation level from the wire was mea-' sured using a yellow face Juno" and a reading of approximately 60 rads per hour uncorrected as read on the Juno was obtained.
Sputter deposition of each coating or containment layer was done in two steps in a MRC Model 8620 RF sputtering systemlocated in a glove box. The'active wire was mounted on a simple holding fixture consisting of two support wires silver-brazed to a 5-inch stainless steel disk and bent to support the wires l/4 inch above the disk. It was necessary to open the chamber and to turn the wire over to sputter the containment on the reverse side. The chamber was evacuated to 3 X Torr before back-filling to 4.5 millitorr of argon. The first platinum containment layer of approximately 7,500 A was sputter-deposited at a power of 250 watts on a S-inch-diameter target, zero bias, 800 volts RF peak to peak. The 7,500 A estimate is based on deposition rates for platinum previously established at 3.22 microns per hour at 500 watts by metallographic techniques. The chamber was vented to argon, opened, the wire turned over, and pumped down and platinum sputtered on the other side. 7
After the first complete containment layer had been sputtered on, the wire was removed to an open-faced hood and smearability and activity checked. After a light rub on the wire, a Q-tip counted 200-300 disintegrations per minute. Alpha activity on the yellow face Juno had dropped to 25 rads per hour uncorrected. The wire was then carefully rubbed with tweezer tips which had been wrapped with optical lens paper in order to knock off any high peaks of plutonium oxide.
The wire was then placed back in a sputtering chamber and approximately 3,500 A of platinum was deposited using the same sputtering conditions as for the first containment layer. After sputtering, the wire was smeared with Q-tips and facial tissue and only background count was noted, which is less than 25 disintegrations per minute. The alpha activity as read on the yellow face .luno was 12.5 rads per hour on one side and rads per hour on the other side.
An alpha-energy analysis was run on the completed device. using a 400-channel alpha-energy analyzer. The results showed the absence of any alphas having the 5.5 MeV energy characteristic of Pu which was convincing evidence that the activity is contained until such time that the platinum containment is either damaged through handling or eroded away by the blood flow. A peak was located at about 4.82 MeV and calculation of the thickness ofthe containment layer based on the energy analysis indicated a thickness in reasonable agreement with that projected from the deposition rate data.
Following sterilization with 400,000 rads of gamma radiation, the device was implanted in a beagle dog. In the present case. insertion was accomplished, while the dog was anesthetized as for any surgery, by passing a long steel needle obliquely through the artery and drawing the irradiator device through the needle by means of a suture thread and suturing. through the loops of the device at both ends, to the wall of the blood vessel following removal of the steel needle. With this technique. there is little disturbance of the blood vessel. Radiographs taken subsequent to implantation showed thewire continuing in place. The other surgical procedure contemplated for use with the present device will be to dissect. the descending aorta, make two small slits on opposite sides of the blood vessel and 2 inches diagonally apart, insert the wire and anchor it with sutures also used to close the slits. This procedure is much simplified over the previously used method of removing a part of the aorta and suturing in its place a multilayered tube with woven fiber ends.
Two of the devices were implanted in dogs. The first device was nonradioactive and'was implanted to develop techniques and to check thrombic effects of the wire itself. The device with the radioactive layer was subsequently imp'lanted. After days, there was no gross evidence of thrombic effect in either animal but total absence of clotting can be confirmed only after the animal is sacrificed. While Pu was used as the source in the present instance, it is possible that because of the very short range of alpha particles and the difficulty of detecting any leakage, should a leakage subsequently develop, it is possible that beta emitters will prove to be preferable as the active radioisotope. A beta emitter would provide a radiation which is suffi' ciently penetrating to give a sufficiently high dose rate to the blood and yet is not so penetrating that it would be damaging to surrounding tissue. Use of more penetrating beta radiation would also have the advantage that a thicker containment layer could be used, insuring its integrity and containment of the radioisotope without reducing the radiation level to unacceptably low values. 1
The embodiments of the invention in which an exclusive property or privilege is claimed'are defined as follows:
1. An in-vivo radioisotope blood irradiator for invessel radiation treatment of blood comprising: a wire including a straight section and a small oppositely facing loop at each of the two ends thereof; an active radioisotope-layer deposited over the center portion of said straight section of the wire; and a coating-layer sealingly covering said active radioisotope-layer; said wire adapted for implantation diagonally transverse a blood vessel in a manner so that said active layer lies fully within said vessel and said ends project such that said two loops lie fully exterior to said vessel.
2. The blood irradiator of claim 1 further comprising suture means associated with each of said loops for anchoring said wire with respect to said blood vessel.
3. The blood irradiator of claim 1 wherein said wire is stainless steel spring wire about 0.01 inch in diameter and slightly in excess of 2 inches in length, said loops are about 0.04 inch in diameter, the centers of said two loops are about 2 inches apart, and the active radioisotope-layer is deposited over the center 1 inch of said wire.
4. The blood irradiator of claim 3 wherein said active 4 radioisotope-layer comprises PuO and said coatinglayer comprises platinum.
5. A method for in-vivo radiotherapy of blood by irradiation of the blood within a blood vessel comprising:
a. depositing a layer of an active radioisotope on the center portion of a wire which includes a straight section and a small oppositely facing loop at each of the two ends thereof;
b. depositing a coating-layer over said active radioisotope-layer so as to sealingly cover said radioisotope;
c. sterilizing said wire; and
d. implanting said wire in said blood vessel by surgically inserting the wire diagonally transverse said blood vessel in a manner so that said active layer lies fully within said vessel and said ends project 3,81 1,426 7 8 such that said two loops lie fully exterior to said is deposited on the center portion of 21 Stainless steel vessel s wire by electroplating from a solution containing 6. The method of claim further comprising: suturmpuo and a thinvcoafin- 4a er of lafinum is de os ing through said loops to anchors'aid wire with respect 2 g Y P P to id bl d vesseL 5 ited over said PuO by vacuum sputtering.
7. The method of claim 5 wherein a layer of "F'u0
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