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Gallery: EPA Demands BP Stop Using Toxic Dispersants, They Won't Comply
As we all know, the oil spill in the Gulf of Mexico has not yet been contained and has finally reached the Gulf Coast shoreline. Last week, after some careful monitoring of the depths of the Gulf the Environmental Protection Agency (EPA) ordered BP to halt the use of the chemical dispersant, Corexit, which they were using to break up massive amounts of oil. The EPA now believes that Corexit is highly toxic, so BP was given 24 hours to find new, less harmful solution. BP responded by saying that Corexit isn't as toxic as they think, and after giving a vague explanation told the EPA that they were just going to keep on using it because it's working fine.
4 Comments
June 24, 2010 at 11:53 am
Please for the love of our earth's creatures and the world we live on, USE THE ORGANIC METHOD TO CLEAN THIS!!!! I'm sooooo damned angry that the lives of so many rely on the corporate corruption taking place; whereby the company providing the chemical dispersants is making a profit off of this and most likely kicking paybacks to BP. Come on Obama, speak up! Please stop this!!!
June 17, 2010 at 1:56 pm
[…] exclusively also appears unfounded. The EPA has approved the use of 81 dispersants and has asked BP to use less […]
May 25, 2010 at 3:16 am
A Totally Safe And Completely Organic Way To Clean Up The Oil In The Gulf Of Mexico…
May 24, 2010 at 12:38 pm
I would like to take the opportunity to make the public and BP aware that Nanotechnology Products already exist for such clean-up situations, as the one this nation presently faces in the Gulf of Mexico.
Green Earth Technologies sells a product line called, G-MARINE Fuel Spill Clean-UP! (NANO Emulsion Technology) Non-Toxic Oil Dispersant. G-MARINE Fuel Spill Clean-UP! is a unique blend of plant derived, water based and ultimate biodegradable ingredients specifically formulated to quickly emulsify and encapsulate fuel and oil spills. These plant derived ingredients are processed to form a colloidal micelle whose small particle size (1-4 nanometers) enables it to penetrate and breakdown long chain hydrocarbons bonds in oils and grease and holds them in a colloidal suspension when mixed with water. Once oil has been suspended in a nano-colloidal suspension, there is no reverse emulsion; the oil becomes water soluble allowing it to be consumed by resident bacteria in the water. This dispersant formula is protected by trade secrets pursuant to Occupational Safety and Health Agency (OSHA) Standard CFR-1910 1200. The ingredient list has been reviewed by the US EPA and contains no ingredients considered hazardous by OSHA.Recent
Press Release:
Green Earth Technologies Website:
I am attempting a grass-roots approach, because I believe the company, this product to be quite beneficial, not only for this recent crisis, but mother earth as a whole going forward. Thank you for you time and patience.
Maurice Johnson


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the Naval Hospital Great Lakes (NHGL), it was never formally defined. Dictionary definitions of integration range from the process of joining entities together1 to the process of blending into a functioning whole.2 These definitions could apply to very different situations, for example, the simple collocation of DoD and VA clinics in the same building that share a laboratory versus a more ambitious unification of like clinics that are jointly staffed and serve both Department of Defense (DoD) and VA beneficiaries. According to the Lovell FHCC's concept of operations, the planning assumptions supported the more expansive concept of integration. The assumptions included the following:
Although the vision of the FHCC planners was total organizational integration, including single operating systems, blended staff, and seamless care delivery regardless of beneficiary status, the implementation history in North Chicago reveals the limits to and the costs of integration, as well as some of the beneficial outcomes that might be realized from the creation of the FHCC. The limits pertain to differences between the beneficiary populations in terms of health needs and eligibility; differences in the departments' missions in North Chicago (i.e., preparing recruits for deployment versus meeting the health needs of veterans); the limited ability of the two EHR systems to interface to allow an integrated patient record; and the need to continue to meet different standards and reporting requirements of the agencies (the VA, the Navy, and the DoD). The costs pertain to the extra time it takes to meet the requirements of two reporting chains; the duplication of functions that could not be unified; and the need to develop and maintain interoperability capabilities between separate systems (e.g., EHR systems, accounting systems, credentialing systems, drug formularies). The
1 "1. To make a whole by bringing all parts together; unify; 2a. To join with something else; unite; 2b. To make part of a larger unit" (American Heritage College Dictionary, 3rd ed., Boston, MA, Houghton Mifflin, 1997).
2 "To form, coordinate, or blend into a functioning or unified whole: unite" (Webster's Ninth New Collegiate Dictionary, Springfield, MA, Merriam-Webster Inc., 1987).

subset: commoncrawl


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Toastmasters TLI-West Summer 2015
- Business & Professional
- 3300 River Dr, Moline, IL, 61265
Promoting Undergraduate Research at Liberal Arts Colleges
Augustana College
Saturday, April 6, 2013 from 9:30 AM to 3:30 PM (CDT)
Promoting Undergraduate Research at Liberal Arts Colleges is intended to bring faculty, staff and administrators together to consider some of the challenges of research at the undergraduate level. We have a wealth of programs, experiences, and successes to share. The day will feature a keynote speaker and then a variety of concurrent sessions on topics such as securing funding, scaffolding background learning, celebrating student work, rewarding faculty and changing institutional culture. We hope you will join us in sharing your expertise and learning about the work of others.
|9:30 a.m.
|Registration, coffee and treats
|10 a.m.
|Keynote speaker (TBD)
|11 a.m.-12:15 p.m.
|Concurrent sessions
|12:30-1:15 p.m.
|Working discussions lunch
|1:30-2:15 p.m.
|Concurrent sessions
|2:30-3:30 p.m.
|Current sessions
Cost: $50
Please make your check out to Augustana College and send to:
Augustana College
c/o Ellen Hay
639 38th St.
Rock Island, Ill. 61201
Augustana College is a private, selective liberal arts college located on a 115-acre campus near the Mississippi River in Rock Island, Illinois. Visitors rave about the beautiful wooded campus, with its rolling, river valley landscape and winding pathways along the slough. It truly is an oasis within the city.
Our focus on creating a well-rounded experience for our students has generated an environment of learning that goes way beyond the classroom. From the moment students set foot on campus, we provide them with the tools that will help them be successful here at Augustana and beyond. In addition to working closely with their professors on special projects and research, students will benefit from visiting scholars and lecturers as well as international study opportunities.
The Augustana community offers our students opportunities to be more than scholars, through hundreds of student interest groups and activities, tools and resources to discover their paths in life, and outstanding NCAA Division III athletic programs. In fact, Augustana ranks fifth among all colleges and universities for total number of Academic All-Americans. This environment that cultivates successful students also extends beyond our campus through community programming as well as special networking and social opportunities for our alumni.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Claregalway Hotel3
Claregalway Village, Galway, Co.Galway
Price FromView Rooms
- Excellent
- 4 guest reviews
"Hi stayed here for a family wedding great hotel very well looked after by staff food was excellent would recommend this hotel..."
"Me and my wife booked a wheelchair room we have had bad experience in the past with hotel calming there wheelchair friendly so we were kinda..."
"We liked the location. The wifi was good to very good..."
About the hotel
A modern Family run hotel, offering the highest standards in accommodation, leisure club and spa facilities. Just 3km from Galway Airport and 8km from Galway City. The Bistro restaurant is highly acclaimed for its truly exceptional experience.
TI Cisacks Bar invites you to enjoy a drink in the company of locals, friends and guests. Our fully equippedleisure club and spa suites provides 18m swimming pool, gymnasium, Jacuzzi, steam room, spa treatment rooms & seaweed baths.
Read MoreLess
Room Availability
Showing Sunday 5 July 2015 to Monday 6 July 2015Change Search
We currently have no rooms available for this hotel that match your search criteria. Try changing your search or select an alternative hotel.
Facilities Show/hide
- Main
- Disabled Facilities
- In room facilities
- Air conditioning in rooms, Trouser press in each room, Iron And Board In Each Room, Telephone In Each Room
- Hotel services
- 24 Hour Reception, 24 Hour Room Service, Laundry/Valet Service, Wake Up Call Available, Currency Exchange
- Family friendly
- Cots available
- Parking
- Car parking available onsite
- Business
- Wi-Fi Available, Wi-Fi Available In Rooms
- Dining
- Restaurant, Breakfast to go
- Leisure
- Gymnasium, Indoor Pool, Sauna, Steam Rooms, Massage, Beauty Salon/Manicure, Jacuzzi, Snooker/Billiards, Fishing
- In room entertainment
- TV, Satellite TV
- Accessibility
- Disabled Access Public Areas, Disabled Access Bedrooms, Disabled toilets on ground floor, Wheelchair Access, Wheelchair Access To Reception, Wheelchair Access To Restaurant, Wheelchair Access To Bar, Wheelchair Access To Conference Rooms, Wheelchair Access To Leisure Facilities, Wheelchair Access To Disabled Car Parking Spaces
Useful Info Show/hide
- From 15:00 hours
- Until 11:30 hours
- The price shown is based on the occupancy and dates you have searched for. Prices and availability are subject to change based on the arrival date, number of nights and occupancy searched for. All prices are inclusive of all local taxes.
- Pets are not allowed
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
100% would recommend it to a friend
Customer service
Food quality
Room quality
Our Stay was hassle free & enjoyable.
Great hotel
Hi stayed here for a family wedding great hotel very well looked after by staff food was excellent would recommend this hotel


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View Singles in Index
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The Evergreen State of Washington. With millions of members, someone's sure to catch your eye. Whether you're looking for Christian singles, Black singles, Asian singles, Jewish singles or local singles, go to the dating site that is responsible for hundreds of thousands of happy couples. Select from thousands of Index date choices on the largest online dating site.
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Original recipe yields 4 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Ready In
Wow, this was great, but I did make the following changes. I made a pound of penne, I used only sweet italian sausage (though I think it would be great with the combo too). I used an entire on...
I love this recipe! I made it again tonight and my guests gave it a 10/10. I used mild Italian sausage and added cajun seasoning. Delicious!
This was absolutely delicious - my husband loved it too. Next time I'll use 2/3 or half as much sausage. I also mixed in the cherry tomatoes while the pan was still simmering so they could sof...


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Our LO loves to stand up and really loves when we hold him up and let him "walk" across the floor. I noticed that he curls his toes really tightly as he's "walking" and I'm wondering if when they are this young it is normal or if this could be a sign that it might be an issue in the future. Anyone else notice that their LO curls his/her toes when you stand them up and let them walk? If it's possibly going to be an issue are there ways to help them flatten their feet out?
Baby curls toes
baby girl curls her toes all the time. I hope its normal. I never thought otherwise, but I am a FTM!
FTM Mom to Baby Girl Stormy Born April 1st!
I believe it's just a reflex they have because of the sensation that's put on their foot. I read somewhere that depending on which part of the sole you stoke, the baby will curl or spread out their toes in response.
I also noticed that all my nieces and nephew did this, so I just presumed a while ago that it was normal.
Cora 4/5/10 Ike 8/14/11
Bibbidi boddidi
I'm afraid I have no choice but to sell you all for scientific experiments.
I am bumping this to see if anyone still notices this?
I just started putting my daughter in her jumperoo and she always curls her toes when she is on her feet.
My son always does this, whether he's sitting, lying down, etc. I have started to wonder if it meant anything ....
Ian William is here!!! 4/30/2010
Yep, Laynee does it a lot!!
I love you to the moon & back.....
Mine too...It must hurt to jump on the backs of their toes! (Mine doesn't even jump in her jumperoo, just kind of squirms...)
Mama to Anna Lily, born in our hearts many years ago, born into our arms on 3/21/10 (due 4/24/10)
Pieces of a Sometimes Extraordinary Life
Mine also curls his toes up, even when they are in his mouth
Laura + Hubby= Skinny Lil' Man & Chunky Lil Man
Maybe baby #3! (THINK PINK)
I talked to the twins' pediatrician about this yesterday because my son does it and I read that it's a preemie problem that sometime is taken care of with massage therapy.
Their pediatrician said that the toe curling thing is normal, it's just a reflex. He said that it's not a preemie issue, it's a baby issue. He said that as long as the baby can flex its foot (i.e., when baby's legs are in the air, baby flexes his/her feet) it's fine. He also said to try this: pick baby up and put him to the ground heel first. If baby's heels touch the ground, baby is normal.
Thanks for the info Nicki
I love you to the moon & back.....


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Section 2
Optimal control simulations of human arm motion
Article first published online: 3 DEC 2012
DOI: 10.1002/pamm.201210041
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: 83rd Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), Darmstadt 2012; Editors: H.-D. Alber, N. Kraynyukova and C. Tropea
Volume 12, Issue 1, pages 99–100, December 2012
Additional Information
How to Cite
Maas, R. and Leyendecker, S. (2012), Optimal control simulations of human arm motion. Proc. Appl. Math. Mech., 12: 99–100. doi: 10.1002/pamm.201210041
Publication History
- Issue published online: 3 DEC 2012
- Article first published online: 3 DEC 2012
- Abstract
- References
- Cited By
Using multibody systems to represent bones and joints is a common way to simulate human motion. Often, this is done with inverse or forward dynamics (solving initial value problems). However, many simulation tasks in biomechanics lead to boundary value problems, like performing a motion from a given start to a prescribed end position, which could be performed in various ways. In this context, we suppose that human motion is controlled in order to perform an optimal motion. Hence we formulate an optimal control problem (OCP) and compare the results when using different physiologically motivated cost functions. A direct transcription method called DMOCC (see [1]) is used to solve the OCP, whereby we benefit from it's structure preserving formulation, as the resulting optimal discrete trajectories are symplectic-momentum preserving. (© 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)


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Town Square
Measure A: How will local towns spend park, recreation money?
Original post made by Good neighbor, another community, on Oct 3, 2006
The measure would authorize a 1/8 cent sales tax in San Mateo County -- at an annual cost per person of $18.10 -- for parks and recreation functions.
Among specific annual allocations to your towns:
- Atherton, $205,000
- Menlo Park, $328,733
- Portola Valley, $205,000
- Woodside, $205,000
- Ladera Recreation District, $90,660
- Midpeninsula Open Space District, $634,620.
Does anyone out there know how the local towns plan to spend this money?
For more information or to volunteer for the campaign, e-mail: email@example.com, or go to: Web Link
The phone number is (650) 794-2000.
Don't miss out on the discussion!
Sign up to be notified of new comments on this topic.
Lutticken's owner opens Main & Elm in Redwood City
By Elena Kadvany | 8 comments | 2,739 views
OK I Changed The Title
By Laura Stec | 24 comments | 1,892 views
Relay for Life, Menlo Park, August 8
By Chandrama Anderson | 0 comments | 767 views


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AMERICA/VENEZUELA - Dialogue and truth, the Catholic community in favor of a clarification
Maracay (Agenzia Fides) - Commenting on the various political events that have recently sparked the debate at a national and regional level, the Bishop of the Diocese of Maracay, His Exc. Mgr. Rafael Ramón Conde Alfonzo, has launched an appeal for peace and for dialogue among all Venezuelans.
According to the note sent to Fides Agency, the Deputies of the Legislative Council of Aragua belonging to the party "Primero Justicia", have in fact delivered a document to His Exc. Mgr. Rafael Conde, asking for his intervention in the case of the deputy of the National Assembly, Richard Mardo, accused of fraud and corruption by the National Assembly. The president of the parliament has called for the deputy's arrest and the suspension of parliamentary immunity. Public opinion is divided because the deputy worked for more than 15 years to help the needy and even received the honorary citizenship by the municipality of the city of Caracas. The legislator Elias Bermudez said that the Church in Venezuela is an institution for peace and truth, and that has always been on the side of the people struggling for the welfare of the needy. This is the why the Church has been asked to intervene in a case that has become a debate at a national level.
During the press conference convened by the Bishop of Maracay, Mgr. Conde has asked for understanding, tolerance and respect for all citizens. "We need to be open to dialogue to talk and listen," he reiterated. In his reflection on the situation, he noted that "in Venezuelan society it is necessary to respect the rights and obligations of all citizens, so that in every adversity there is the possibility of a peaceful solution and in this way national coexistence can be ensured". (CE) (Agenzia Fides 26/07/2013)
Receive News from Fides Service in your email
- 2015-06-22 - Hunger strike in 12 states for political prisoners, the Church has been asked to intervene
- 2015-06-19 - "They have our support": Mgr. Conde receives young people on hunger strike and writes to the Pope
- 2015-06-05 - Appeal to the authorities in favor of protesters on hunger strike
- 2015-06-03 - The Church calls on the authorities to respond to the students on hunger strike
- 2015-05-30 - Six young people on hunger strike in a church in Caracas
- 2015-05-19 - Casa-Hogar "Padre Machado" in El Valle occupied with violence for a few hours
- 2015-03-03 - Classes suspended in the University of Tachira, false accusations made against the Catholic University
- 2015-02-27 - The Bishops: "Stop murderous violence!"
- 2015-02-25 - More violence and protests: 6 dead in six days of demonstrations
- 2015-02-24 - Growing tension in the capital, Cardinal Urosa denounces murder of 3 students


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Ratings based on 226 Verified Reviews
They paid and stayed. We double-checked.
4.7 Room cleanliness
4.7 Service & staff
4.6 Room comfort
4.7 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
for Couplesby A verified traveler from Toronto
Right next to shopping mallPosted Jun 30, 2015
Pros: Location: good base for visit DC and Baltimore together.
Cons: With large panel TV prices dropping every year, the hotel should able to afford another TV in the rooms so that everyone can watch TV together.
Location: Shops, restaurants and casino
The hotel is about 10 minutes from BWI airport but right next to the Arundel Mills shopping malls. The mall has all the brand names stores and wide range of restaurants. It is also half way between DC and Baltimore. We used it as a base for visits to both cities. Room size is adequate but the layout is awkward. There is a partition between the sitting area and the beds so you can only watch TV from one of the beds. Breakfast is good and the staff replenished it continuously.
for Everyoneby A verified traveler from Ontario, Canada
Beautiful hotel - very artsyPosted May 1, 2015
Pros: Beautiful
Cons: Pool size
Location: Lots of shopping and local eats within two blocks. Well located.
Everything from the carpet and paint, to the fixtures and amenities seem to be selected by a designer. Very casual and relaxing environment. Great staff, great hotel. Love it. Pool is a bit small but par for hotel pools. Hot tub same story. LOVED IT!
for Everyoneby A verified traveler from newport news va
Nice hotel close to casinoPosted Apr 13, 2015
Great stay pool was a plus staff was nice and also getting a shuttle to the casino and a great variety of restaurants in there area. A wonderful place to b live!!!
for Everyoneby A verified traveler from baltimore
RoomsPosted Mar 25, 2015
Spring hill is a lovely hotel just didn't have the right room and couldn't get my refund back!
for Familiesby David from Waterloo, ON
Pool and breakfest, great combination with kids.Posted Mar 24, 2015 on Hotels
We got in late and got straight to our room. The suite part is nice as the kids could share the pullout. Close to a large shopping mall so it was nice to stop over and check things out. We had some very noisy guests next door and when the kids were kept up we called down and the noise stopped almost immediately, so they followed up quickly. Breakfest was good, and the value was great. The pool was good with the kids, but the lifeguard is very distracted watching March Madness on his laptop and we seemed to be annoying him but actually using the pool. Overall the hotel was clean, and we would stay there again if in passing through the area.
for Everyoneby A verified traveler from y
close to my familyPosted Mar 23, 2015
My first visit was great with 2 full beds..my 2nd stay I also need the same 2 full beds..but unfortunately it was booked...when I checked in I asked if I could get additional bedding the reply I got was it in your room..but I just wanted 1 more pillow and blanket because my son doesn't like to share with his brother..the pool had way too much chlorine we only stayed in there for 10 minutes it burned my eyes and kids.
for Business Travelersby Isael from Philadelphia
GreatPosted Mar 21, 2015 on Hotels
Great time
for Familiesby ed from Newark De
GREAT Stay!Posted Mar 11, 2015 on Hotels
GREAT Stay!!! Only complaint is hotel was crowded with kids...BUT it was Saturday night and they have an indoor pool and hot tub. I should have known. Overall, staff was great and very helpful. Beds were like pillows, sound sleep. Thanks.
for Personal Eventby Connie from Virginia
Quality of servicePosted Mar 10, 2015 on Hotels
I stay at this hotel very frequent and my service has always been good. The staff is friendly and accomendating. The only issue is the shuttle service. The driver was unprofessional and rude.
for Familiesby Monique from edgewood
Good stay for the pricePosted Mar 6, 2015 on Hotels
Very comfortable.. my family and I enjoyed our stay. The hot breakfast was very good and my children enjoyed the waffles would stay again


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If you enjoy this page or know of someone who would find it useful, please share……..
View Valencia Summit Homes for Sale
Relocating? or just moving within the Southern California area?
Floor Plans and More!
To view floor plans, please click on the neighborhood of interest in the right sidebar. You will be able to view listings, floor plans, photographs of actual floor plans and find out more on the neighborhood itself.
Valencia Summit Homes for Sale
Listings Available TODAY!
Please click on the photograph or the address of the properties you will find below to view details, large photographs, aerial views and more. If you have questions, please call Pia Soper at 661 645 5556 or contact me through a way easiest and most comfortable for you, found below the listings. Enjoy!
$925,000 : 26284 Park View Road, Valencia4 beds, 4 full baths
$819,900 : 26243 Park View Road, Valencia3 beds, 3 full baths
$674,900 : 24456 Mockingbird Court, Valencia3 beds, 3 full baths
$669,000 : 24155 Saint Moritz Drive, Valencia4 beds, 3 full baths
$555,000 : 24518 Windsor Drive, Unit A, Valencia3 beds, 3 full baths
$522,000 : 24418 Hampton Drive, Unit A, Valencia3 beds, 3 full baths
$482,600 : 24432 Hampton Drive, Unit A, Valencia3 beds, 3 full baths
$464,900 : 24442 Hampton Drive, Unit B, Valencia2 beds, 3 full baths
See all Valencia Summit Home Search.
(all data current as of 6/29/2015)
Listing information deemed reliable but not guaranteed. Read full disclaimer.
If you would like to visit any of the homes or have any questions, please give me a call at 661 645 555o


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A collection of news and information related to Dana Rohrabacher published by this site and its partners.
Top Dana Rohrabacher Articles
Displaying items 100-110
Lawmakers urge that Chinese poultry be blocked from school lunches
Bipartisan group seeks to bar Chinese chicken from nutrition programs
Political Landscape: Curry wins backing of RohrabacherStory | May 23, 2014 | 7:53 PMAs the June 3 primary nears, candidates for the 74th Assembly District continue to battle for votes. U.S. Rep. Dana Rohrabacher (R-Costa Mesa) endorsed Newport Beach City Councilman Keith Curry for the seat, which represents Newport, Costa Mesa,...
Commentary: Rohrabacher should shift climate-change positionStory | May 9, 2014 | 9:26 AMU.S. Rep. Dana Rohrabacher's continuous propaganda rejecting human-caused climate change puts our economy, national security and children at risk. If he does not change his position, it is time for the voters of his district to replace him. This week...
The GOP does the climate change dance
Curry, Harper likely headed to run-off
Venezia: Roaming Newport-Mesa on election night
Race for Eric Cantor's House post may be between Californian, Texan
Protestors demonstrate outside Rohrabacher's officeStory | Jul 27, 2011 | 4:05 PMAs the intense debate about lifting the debt ceiling continued to paralyze Washington, about three dozen people protested Tuesday afternoon outside the office of Rep. Dana Rohrabacher (R-Costa Mesa) in downtown Huntington Beach. The picketers, many of...
Mailbag: Contract a burden to taxpayersStory | Aug 10, 2011 | 4:12 PMDespite Huntington Beach's fall into financial oblivion, despite ludicrous employee packages agreed to by our City Council, despite the fact that nearly half of the 28 speakers at the council meeting Aug. 1 protested and pleaded with the council to let...
Redistricting changes 2012 electoral battlesStory | Aug 15, 2011 | 10:46 PMThe battle between two Republican congressmen for a local seat in 2012 will not happen, according to the state's new legislative maps finalized Monday by the California Citizens Redistricting Commission. Congressman Dana Rohrabacher (R-Costa Mesa) said...


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Narrow your search
With better battery life and performance than the Yoga 3 Pro (not to mention a lower price), the Yoga 3 14 is one of the best hybrid deals around.
The Apple Watch is the most ambitious, well-constructed smartwatch ever seen, but first-gen shortfalls make it feel more like a fashionable toy than a necessary tool.
The iPhone 6 Plus is an outstanding choice for those with big budgets and big pockets, but power users seeking even more flexibility should audition the Galaxy Note 4 as well.
The iPad Air 2 is a nice refinement and finesse of last year's model, with a bevy of tweaks, enhancements, a much faster processor, and the welcome addition of Touch ID. Simply put: it's still the gold standard for tablets.
The Toshiba Kirabook is still a worthwhile high-end Windows alternative to a Retina MacBook Pro, but it could use a little of that Apple secret sauce for its touchpad.
The Asus ZenFone 2 is too expensive for its above-average ability, but if the price agrees with you, the smooth performance and splendid low-light camera won't disappoint.
The Klipsch Reference Premiere speakers and subwoofer deliver maximum home theater dynamics and power with ease, and sound great with music, too.
While owners of NFC-enabled phones will benefit from the MiniStation drive's convenient encryption unlocking feature, there are cheaper and faster options available for those with simpler needs.
Whether it's for gaming, multimedia enjoyment, work or all of the above, the Razer Blade is a fantastic choice if you need high performance but don't want to sacrifice mobility to get it.
The Acer Revo is a do-it-all media-friendly PC that can fit anywhere.


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Reports Of A Murder – Suicide In Schenectady
Schenectady Police responded to a situation about a person with a knife at 6 Mynderse Street earlier this afternoon.
Schenectady Police responded to a situation about a person with a knife at 6 Mynderse Street earlier this afternoon.
Saratoga Springs - Saratoga residents who like to frequent city bars, especially in summer time, could see an earlier last call by bartenders.
Capital Region-Gas prices once again are fluctuating, but not in favor of the consumer.
New York- Police chased a convicted felon yesterday over 40-miles of the thruway with speeds of up to 100 mph. The Rochester man led troopers on the chase from Fultonville to Albany.
California- The Nuclear Regulatory Commission is investigating a possible leak of radioactive steam. Apparently, a sensor detected the possible leak.
Natural gas has caused a house explosion in Schenctady.
If you have to travel on Interstate 890 in Schenectady, use a little extra caution.
Here's what is happening in the news around the Capital Region.
Here are the three top stories from today's news that might be of some interest to you:
When you've been doing something as long as Kenny Rogers has been making music, the milestones are bound to pile up — and sure enough, this holiday season will mark an auspicious anniversary for the country legend.
When Rogers embarks on his annual Christmas and Hits tour this November 25, it'll mark his 30th straight year of heading out on the road to bring holiday cheer to fans. Billy Dean will join Rogers for the 17-date run, which concludes December 23.
I would think that most of us would love to win the lottery or have a phone call that says we won some contest for a lot of money! We all have that to good to be true dream. Locally, there is a scam preying on folks who have those dreams.


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Married since 11.02.11
A simple video to reminisce the good times we had celebrating our anniversaries.
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Nathan Churchill - Coldwell Banker Residential Brokerage
Nathan Churchill
re\\Realtor Associate
Address: 1801 Lombard St San Francisco, CA 94123
Contact: Direct: 415.297.4426 Office: 415.447.8809 Fax: 415.447.8884 Email: email@example.com
Languages: English
- Over 30 years of full time experience in San Francisco real estate. Top Producer with many hundreds of millions in sales involving houses, condos, flats, apartment buildings and commercial property.
- Universities of Minnesota and U.C. Berkeley, Fuller theological Seminary, B.A., M.A.
- Providing exceptional opportunities and service for clients in the competitive and dynamic San Francisco real estate market, whether they be sellers, home buyers or investors.
- San Francisco, California and National Association of Realtors, Coldwell Banker International President's Elite (C.B.'s highest award).
- Originally from the Midwest, San Francisco resident since 1968. Educaitonal background in History, Classics, Archaeology and thology. Loves San Francisco for its natural beauty and world culture. Lives in Ashbury Heights.


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: FireRed hack:
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August 18th, 2007 (01:39 AM).
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Sorry for the late replay zel but welcome back. And you know that I highly love your hack. But I can't play it at the moment. I don't have any ROM... But I play it asap when I have my FR-ROM. Keep on.
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Fire damages Phoenix apartment complex
PHOENIX -- A large three-story apartment complex in northwest Phoenix sustained significant damage from a Thursday night fire.
Capt. Ruben Saavedra said multiple crews were summoned after responders arriving at the scene found fire on the second and third floors plus the roof of the complex near 28th Avenue and Cactus Road.
Two people were displaced by the fire, but no injuries were reported.
Cause of the fire is under investigation.


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Just before noon on Tuesday, May 11, the U.S. Senate agreed to a one-time audit of the Federal Reserve's emergency actions taken in response to the 2008 financial crisis. The approved audit, which Senator Bernie Sanders (I-Vt.) offered in an amendment to the larger financial regulatory reform legislation, is a much watered-down version of the earlier audit proposed by Sanders that mirrored the "Audit the Fed" legislation in the House sponsored by Rep. Ron Paul (R-Texas).
Finance ReformWritten by Charles Scaliger
With a congressional battle brewing over what is being touted as the biggest attempt at financial regulatory reform since the Great Depression, most pundits are predicting that, despite token Republican opposition, some version of the bill that originated with Senator Chris Dodd's Finance Committee will soon pass. Senate Republicans blocked the first attempt to bring the matter to a vote on April 19, but Democrats and the Obama administration vowed to continue to press wavering Republicans to support the bill.
The timing of the sellout by Senator Bernie Sanders (I-Vt.) last Thursday, May 6, on legislation to audit the Federal Reserve could not have been more auspicious — or more suspicious. After pledging for months that he was going to offer an amendment in the Senate identical to "Audit the Fed" legislation in the House (H.R. 1207) authored by Congressman Ron Paul (R-Texas), Sanders caved in to pressures from the Obama administration and the Federal Reserve.
Senate Democrats beat back a Republican alternative amendment to Connecticut Democrat Christopher Dodd's Restoring American Financial Stability Act of 2010 (S. 3217) and will soon consider an amendment to audit the Federal Reserve Bank authored by Louisiana Republican David Vitter. The GOP substitute amendment failed in a 38-61 vote May 6.
Jobs Up, Unemployment Rate UpWritten by Gary Benoit
The Labor Department's Bureau of Labor Statistics announced good and bad economic news on May 7: The economy added 290,000 jobs in April compared to March, but the unemployment rate climbed from 9.7 percent to 9.9 percent.


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Lysosomal Storage Disease
(Glycoprotein Storage Diseases; Mucopolysaccharidoses; MPS)
DefinitionLysosomal storage disease is a group of disorders that affect specific enzymes. These enzymes normally break down items for reuse in the cells. If the enzymes are missing or don't work properly the items can build up and become toxic. This occurs in an area of the cell called lysosomes. The build up eventually leads to damage of cells and organs in the body.There are over 40 different types of lysosomal diseases. The diseases are characterized by the specific enzymes involved:
- Fabry Morquio's disease—affects the kidney, heart, and skin
- Gaucher disease —affects the spleen and bones, and causes anemia
- Hurler's syndrome—affects the spleen, liver, joints, and eyes; causes intellectual disability and deafness
- Maroteaux-Larny disease—affects the skin, bones, liver, and spleen
- Niemann-Pick disease —affects the spleen, liver, and lungs
- Pompe disease—affects the liver, heart, and muscle tissue
- Tay-Sachs disease —affects the brain
CausesLysosomal storage disease is caused by a genetic problem. The genes that plan the production of the enzymes is faulty. Both parents must pass the gene on to the child in order for the disease to develop.
|Genetic Material
|Copyright © Nucleus Medical Media, Inc.
Risk FactorsLysosomal storage disease is more common in families with Ashkenazi Jewish, Finnish, or Dutch heritage. A family history increases the chance of the disease as well.
SymptomsSymptoms can be severe and appear shortly after birth or mild and detected later in life. Symptoms will depend on the specific type of disease. Some common symptoms include:
- Recurrent infections or hernias
- Developmental delays
- Problems with hearing or sight
- Problems including pain with bones
- Problems with heart
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Current Research From Top Journals
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Early Peanut Consumption Associated with Lower Risk of Peanut Allergy in High Risk Children
Breastfeeding May Decrease the Risk of Childhood Obesity
Tonsillectomy May Reduce Number of Sore Throat Days in Children
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A systematic review found that participants given chewing gum after abdominal surgery may have a faster return to normal for their digestive system. Unfortunately, the quality of trials is low and more research will need to be done before this simple solution is confirmed.
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Early Peanut Consumption Associated with Lower Risk of Peanut Allergy in High Risk Children
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Watch all fighters weigh in LIVE from Atlantic City! watch video >>
Bernard Hopkins steps in the ring with Karo Murat with the Light Heavyweight World Championship on the line. Plus, Peter "Kid Chocolate" Quillin takes on Gabriel Rosado for the Middleweight World Cha watch video >>
Live from Atlantic City, watch as Bernard Hopkins, Karo Murat, Peter Quillin, Gabriel Rosado, Deontay Wilder, and Nicolai Firtha hit the scales one day before their SHOWTIME Championship Boxing event watch video >>
Highlights from an exciting pre-fight weigh-in featuring headliners: Bernard Hopkins and Karo Murat. Plus, an intense face-off between Peter Quillin and Gabriel Rosado. And, the lighter side of knock watch video >>
Highlights from an action-packed night of SHOWTIME CHAMPIONSHIP BOXING featuring Deontay Wilder vs. Nicolai Firtha, Peter Quillin vs. Gabriel Rosado, and Bernard Hopkins vs. Karo Murat watch video >>
Fearless Philly fighter, Gabriel Rosado came prepared for war against undefeated knockout artist Peter "Kid Chocolate" Quillin on October 26th. Watch every fast and furious round of "Quillin vs. Rosa watch video >>
Watch the official weigh-in for UFC Fight Night: Cerrone vs. Miller, live Tuesday, July 15 at 4pm/1pm ETPT. watch video >>
Watch as main event fighters Donald Cerrone and Jim Miller step on the scale before their July 16 clash in Atlantic City. Evan Dunham and Edson Barboza, fighting in the co-main, also weigh in. watch video >>
Watch the post-fight press conference live following the event. watch video >>
Watch Peter Quillin train for Andy Lee- Full Video- Full workout: Heavy bags/Abs/Mitts For more Boxing and MMA videos log onto http://www.fighthubtv.com Like us:http://on.fb.me/xWRC1f follow us:http watch video >>


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2006 SkillsUSA MARYLAND - Small star STATE CHAMPIONSHIP - Large star - Leaf CAKE DECORATING CONTEST - Rose (amended 1/10/06) Flower nail Two to four small bowls for RULES AND REGULATIONS mixing colors Cake circle 1. Participants must wear clean and neat Food paste colors work whites and hair restraints with no Piping gels (if desired) visible indication of school identity (no school patches, I.D. tags, etc.). 9. Each participant must supply their own icing for the contest: 2. All decorating will be done at the contest site. Do not bring a decorated Four to six pounds prepared cake from your home school. butter cream icing (recipe optional) 3. Each participant will be expected to ice and decorate a 9 x 13 sheet cake for a The following items are optional: child's celebration (birthday, holiday Additional decorating tubes party, etc.). Turntable *no other items will be allowed. 4. Each participant will be expected to ice and decorate a 2 layer, 8" round cake 10. There will be three judges: one from the for an adult function (birthday, sponsoring company, one from the anniversary, shower, etc.). baking industry, and one decorating specialist. Judges will be qualified, and 5. The cakes you decorate for the contest their decisions will be final. will be selected in random drawing. Be prepared to decorate any of the cakes. 11. Judging will be based on: neatness of The theme for either size cake may be decorations, precision, color, overall expanded to include any major holiday appearance, and neatness of work area. or SkillsUSA theme. Judging of speed will be based on order of completion, and will be used only to 6. Teachers, family, and friends of break ties. (For more detailed participants will not be allowed to information on specification for coach the participating students during judging, see attached copy of judging the contest in any way. sheet.) 7. The following items will be provided at 12. Decorated cakes will be sold after the the contest for each participant: contest, or donated to a local charity. 1 – 9x12 sheet cake in foil pan The proceeds from cake sales will be 2 – 8" round layers of cake used to defray expenses of the contest. 8. Each participant must bring to the 13. By signing this form, the participant contest the following items only: verifies that he/she has read and Decorating bags (either understands the rules and regulations, disposable or canvas) and agrees to abide by them. Spatula (for icing cakes and mixing colors) Scissors (for cutting paper Participants Name bags and transferring flowers from nail to cake) Decorating tips (one or more Date of each) - Writing - Figure piping 2006 SkillsUSA MARYLAND STATE CHAMPIONSHIP CAKE DECORATING CONTEST JUDGING SHEET ENTRY # __________ JUDGES' INITIALS _______ A. NEATNESS OF DECORATIONS E. NEATNESS OF WORK 1. Work table is tidy during contest 1. Icing smoothly applied, no participation 2. Equipment is correctly cleaned crumbs showing and stored 2. Entire cake covered and level 3. Work table is wiped clean 3. Uniform decorations 4. Area is free of spills 4. Tube work free of air bubbles, ridges or breaks Excellent _____ Good _____ Fair _____ Poor _____ (20 pts.) (15 pts.) (10 pts.) (5 pts.) Total Points Excellent _____ Good _____ Fair _____ Poor _____ F. SPEED (20 pts.) (15 pts.) (10 pts.) (5 pts.) Finished ________ out of ________ participants B. PRECISION Total Score ________ 1. Borders are piped correctly 2. Garlands are the same width and depth 3. Pastel not so light as to look JUDGES COMMENTS: washed out 4. Flowers are formed and spaced correctly Excellent _____ Good _____ Fair _____ Poor _____ (20 pts.) (15 pts.) (10 pts.) (5 pts.) C. COLOR 1. Appetizing 2. Pleasant color combinations 3. Pastels not so light as to look washed out 4. Appropriate for theme Excellent _____ Good _____ Fair _____ Poor _____ (20 pts.) (15 pts.) (10 pts.) (5 pts.) D. OVERALL APPEARANCE 1. Does not appear over or under decorated 2. Attention is given to "finishing touches" that make cake special 3. Decorations used are appropriate for theme 4. Difficulty of technique attempted Excellent _____ Good _____ Fair _____ Poor _____ (20 pts.) (15 pts.) (10 pts.) (5 pts.)
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Posted May 18, 2004 and updated on April 17, 2009
Why is Veggie Tales: A Snoodle's Tale rated Not Rated?
Official MPAA Rating: Veggie Tales: A Snoodle's Tale is rated Not Rated for
Please read our content details for this movie to help determine if it is suitable for members of your family. We also encourage you to check our full review and our movie information page.


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Jontue Perfume
By Revlon for Women
Jontue Perfume by Revlon, Launched by the design house of revlon in 1975, jontue is classified as a luxurious, flowery fragrance . This feminine scent possesses a blend of orange flower, gardenia, violet, and mimosa. Ending with musk, sandalwood and vetiver. It is recommended for romantic wear. All products are original, authentic name brands. We do not sell knockoffs or imitations. ... Read More
- K De Krizia
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- Kyudo
2.3 oz Cologne Spray
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About Revlon
History and background of Revlon. Revlon is a world leader in cosmetics, skin care, fragrance and personal care and is a leading mass market cosmetics brand. Read more about Revlon
More Revlon fragrancesfor Women: Fire & Ice , Charlie Blue , Ciara 100% , Jean Nate , Charlie White , more
for Men: Fire & Ice ,
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Customer Comments
I got what I ordered when I expected it, and I got it at a great price. I will use them again.
M. Rebelo (Manhattan Beach, CA)
REVIEW SNAPSHOT®by PowerReviews
- Great smell (36)
- Great value (32)
- Draws compliments (25)
- Long-lasting (23)
- Clean & fresh (20)
- Doesn't hold (3)
Best Uses
- Daily use (22)
- Anytime (21)
- Evening (12)
- Signature fragrance (12)
- Special occasions (8)
- Reviewer Profile:
- Natural style (21), Classic style (12), Adventurous style (6)
- Fragrance Type:
- Floral (23), Fresh/aquatic (9), Powdery (7), Citrus/fruity (4), Herbal (3)
Most Liked Positive Review
my favorite prefume
My favorite prefume is Jontue which I couldn't find in Canada anywhere, until I found your website. It came packaged in a box with bubble packing paper. It is in a glass bottle...Read complete review
My favorite prefume is Jontue which I couldn't find in Canada anywhere, until I found your website. It came packaged in a box with bubble packing paper. It is in a glass bottle [...] The price was really inexperience. From now on I will continue to order my prefume from FragranceX.com Thank you so much!I will recommend you to all my family and friends.
Most Liked Negative Review
My wife loves Jontue perfume.
Use everyday.
Use everyday.
Reviewed by 48 customers
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- Great Smell
- Great Value
Best Uses
- Anytime
Comments about Revlon Jontue Perfume:
I used this product since I was Young and I am glad that you still have it because they don't sell it in Canada anymore.
- Fragrance Type:
- Floral, Fresh/Aquatic
- Clean & Fresh
- Don't Ever Discontinue
- Extremely Cheap
- Great Smell
- Great Value
- Long-Lasting
- Memerable Fragrance
- Not Overpowering
- Not Too Strong Or Heady
- Not Sold In Nz Anymore
Best Uses
- Anytime
- As A Work Fragrance
- Daily Use
- Evening Use
- Signature Fragrance
Comments about Revlon Jontue Perfume:
This is a gentle soft fragrance which I use as a daytime product. Of all the other fragrances that I use this is the only one that does not affect my sensitive skin when spraying. Value for money....it is the best on the market and I hope it is never discontinued!
- Fragrance Type:
- Citrus/Fruity
- Clean & Fresh
- Great Value
- Sexy
Best Uses
- Anytime
Comments about Revlon Jontue Perfume:
Use for everyday wear
- Fragrance Type:
- Oriental/Spicy, Woody/Earthy
Best Uses
Comments about Revlon Jontue Perfume:
Adore this perfume so very pretty soft floral sexy romantic scent.spring and summer perfume such a pretty fragrance get so many complaints when im wearing Jontue. (Love it)
- Great Smell
- Not Overpowering
Best Uses
Comments about Revlon Jontue Perfume:
I bought this perfume as a gift for a person who loves it and
wears it all the time. I'm sure that person will welcome the
perfume as she informed me that she was running low on it.
- Fragrance Type:
- Floral
Displaying reviews 1-5
Previous | Next »


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Are you Carlos Martín?Claim your profile
Publications (75)320.02 Total impact
Article: Klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes: Klebsiella intracellular survival[Show abstract] [Hide abstract]
ABSTRACT: Klebsiella pneumoniae is an important cause of community-acquired and nosocomial pneumonia. Evidence indicates that Klebsiella might be able to persist intracellularly within a vacuolar compartment. This study was designed to investigate the interaction between Klebsiella and macrophages. Engulfment of K. pneumoniae was dependent on host cytoskeleton, cell plasma membrane lipid rafts and the activation of PI 3-kinase (PI3K). Microscopy studies revealed that K. pneumoniae resides within a vacuolar compartment, the Klebsiella containing vacuolae (KCV), which traffics within vacuoles associated with the endocytic pathway. In contrast to UV-killed bacteria, the majority of live bacteria did not colocalize with markers of the lysosomal compartment. Our data suggest that K. pneumoniae triggers a programmed cell death in macrophages displaying features of apoptosis. Our efforts to identify the mechanism(s) whereby K. pneumoniae prevents the fusion of the lysosomes to the KCV uncovered the central role of the PI3K-Akt-Rab14 axis to control the phagosome maturation. Our data revealed that the capsule is dispensable for Klebsiella intracellular survival if bacteria were not opsonized. Furthermore, the environment found by Klebsiella within the KCV triggered the downregulation of the expression of cps. Altogether, this study proves evidence that K. pneumoniae survives killing by macrophages by manipulating phagosome maturation which may contribute to Klebsiella pathogenesis. This article is protected by copyright. All rights reserved.Cellular Microbiology 06/2015; DOI:10.1111/cmi.12466 · 4.82 Impact Factor
Article: In vivo IS 6110 profile changes in a Mycobacterium tuberculosis strain by tracking over 14 years[Show abstract] [Hide abstract]
ABSTRACT: Transposition and homologous recombination of IS6110 appear along in vivo sequential infection in Mycobacterium tuberculosis. These events were checked in different clones of a successful strain named MTZ, focusing on a variant in which the integration of a copy of the IS6110 in the origin of replication (oriC) region occurred. Copyright © 2015, American Society for Microbiology. All Rights Reserved.Journal of clinical microbiology 05/2015; DOI:10.1128/JCM.00607-15 · 4.23 Impact Factor
Article: Nonspecific Beneficial Effects of BCG Vaccination in High-income Countries, Should We Extend Recommendation of BCG Vaccination?Clinical Infectious Diseases 02/2015; 60(11). DOI:10.1093/cid/civ148 · 9.42 Impact Factor
Conference Paper: STARTING POINT Optimization of a protocol for extraction of intrapulmonary mycobacterial RNA. (Poster Presentation).[Show abstract] [Hide abstract]
ABSTRACT: Mycobacterium tuberculosis is the causal agent of the tuberculosis (TB) and causes about 2 million deaths a year. The recent rise of the multi-drug resistant forms of TB together with the loss of efficacy of the current vaccine BCG, have made TB a health priority. Deepen the understanding on the host-pathogen interactions during the illness could be key in the development of new drugs and vaccines. Lungs are the site of entry of M. tuberculosis and the first interactions host-pathogen occur in them. The characteristics of this interactions and the ability of the immune system to recognize bacteria mark the success or failure of the infection (1). For this reason, we are interested in knowing the expression profile of the pathogen and the host through the extraction of the RNA directly of the lungs. In addition, the possibility of simultaneously overseeing the expression of both organism by the Dual RNA-Seq technique allow us to know different points of the infection (2). For our purpose, we infected mice by intranasal inoculation and we hope the chronicity of the disease at least 3 weeks prior to euthanize animals. From this point, we tested different protocols found in the literature (3, 4) and other established in our laboratory (5). After each extraction, we check the purity and integrity of the genetic material obtained. Low bacterial load, high content of RNases in lungs and the required purity for the RNA-Seq are the main challenges of the process. References: 1. Talaat AM, Lyons R, Howard ST, Johnston SA. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(13):4602-7. 2. Westermann AJ, Gorski SA, Vogel J. Nature reviews Microbiology. 2012;10(9):618-30. 3. Bold TD, Banaei N, Wolf AJ, Ernst JD. PLoS pathogens. 2011;7(5):e1002063. 4. Chomczynski P, Sacchi N. Analytical biochemistry. 1987;162(1):156-9. 5. Solans L, Gonzalo-Asensio J, Sala C, Benjak A, Uplekar S, Rougemont J, et al. PLoS pathogens. 2014;10(5):e1004183VII Workshop of Training of the Center of Biomedical Research in Respiratory Diseases Network (CIBERES), Valladolid; 10/2014
- [Show abstract] [Hide abstract]
ABSTRACT: Mycobacterium tuberculosis is the causal agent of the tuberculosis (TB) and causes about 2 million deaths a year. The recent rise of the multi-drug resistant forms of TB together with the loss of efficacy of the current vaccine BCG, have made TB a health priority. Deepen the understanding on the host-pathogen interactions during the illness could be key in the development of new drugs and vaccines. Lungs are the site of entry of M. tuberculosis and the first interactions host-pathogen occur in them. The characteristics of this interactions and the ability of the immune system to recognize bacteria mark the success or failure of the infection (1). For this reason, we are interested in knowing the expression profile of the pathogen and the host through the extraction of the RNA directly of the lungs. In addition, the possibility of simultaneously overseeing the expression of both organism by the Dual RNA-Seq technique allow us to know different points of the infection (2). For our purpose, we infected mice by intranasal inoculation and we hope the chronicity of the disease at least 3 weeks prior to euthanize animals. From this point, we tested different protocols found in the literature (3, 4) and other established in our laboratory (5). After each extraction, we check the purity and integrity of the genetic material obtained. Low bacterial load, high content of RNases in lungs and the required purity for the RNA-Seq are the main challenges of the process.VII Workshop of Training of the Center of Biomedical Research in Respiratory Diseases Network (CIBERES), Valladolid, Spain; 10/2014
- [Show abstract] [Hide abstract]
ABSTRACT: Safety of individuals at risk of immune suppression is an important concern for live vaccines. The new-generation tuberculosis vaccine candidate MTBVAC, a genetically engineered doubly attenuated Mycobacterium tuberculosis mutant with deletions in phoP and fadD26 virulence genes has demonstrated comparable safety in different relevant animal models and superior protection in mice as compared to the only currently licensed tuberculosis vaccine Mycobacterium bovis BCG. Here we describe the construction of a highly attenuated MTBVAC-based live vaccine by an additional gene inactivation generated in erp of MTBVAC. The gene product of erp is an exported repeated protein (Erp), a virulence factor described to be involved in intracellular replication of M. tuberculosis. The resultant strain, MTBVAC erp(-), was tested in severe combined immunodeficiency (SCID) mouse model showing to be severely attenuated when compared to BCG and MTBVAC. Experiments conducted in immunocompetent mice revealed that the hyper-attenuated profile observed with MTBVAC erp(-) strain did not compromise its protective efficacy profile in comparison with BCG. These results postulate MTBVAC erp(-) as a potential tuberculosis vaccine candidate for use in high-risk populations of immune suppression (e.g., due to HIV infection), where the use of BCG is not recommended.Vaccine 07/2014; 32(40). DOI:10.1016/j.vaccine.2014.07.047 · 3.49 Impact Factor
Article: Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator.[Show abstract] [Hide abstract]
ABSTRACT: Although the bovine tuberculosis (TB) agent, Mycobacterium bovis, may infect humans and cause disease, long-term epidemiological data indicate that humans represent a spill-over host in which infection with M. bovis is not self-maintaining. Indeed, human-to-human transmission of M. bovis strains and other members of the animal lineage of the tubercle bacilli is very rare. Here, we report on three mutations affecting the two-component virulence regulation system PhoP/PhoR (PhoPR) in M. bovis and in the closely linked Mycobacterium africanum lineage 6 (L6) that likely account for this discrepancy. Genetic transfer of these mutations into the human TB agent, Mycobacterium tuberculosis, resulted in down-regulation of the PhoP regulon, with loss of biologically active lipids, reduced secretion of the 6-kDa early antigenic target (ESAT-6), and lower virulence. Remarkably, the deleterious effects of the phoPR mutations were partly compensated by a deletion, specific to the animal-adapted and M. africanum L6 lineages, that restores ESAT-6 secretion by a PhoPR-independent mechanism. Similarly, we also observed that insertion of an IS6110 element upstream of the phoPR locus may completely revert the phoPR-bovis-associated fitness loss, which is the case for an exceptional M. bovis human outbreak strain from Spain. Our findings ultimately explain the long-term epidemiological data, suggesting that M. bovis and related phoPR-mutated strains pose a lower risk for progression to overt human TB, with major impact on the evolutionary history of TB.Proceedings of the National Academy of Sciences 07/2014; DOI:10.1073/pnas.1406693111 · 9.81 Impact Factor
Conference Paper: Study of the effect of the new tuberculosis vaccine candidate MTBVAC on bladder cancer cells. (Poster and Oral Presentation).[Show abstract] [Hide abstract]
ABSTRACT: Introduction: The use of Mycobacterium bovis Bacillus Calmette-Guérin (BCG) as treatment of superficial bladder cancer is one of the most successful immunotherapy for cancer (1). In the development of a new vaccine candidate for replacing the actual BCG (2), we studied the effect of our genetically attenuated strain of Mycobacterium tuberculosis MTBVAC on the viability of bladder cancer cell lines. Methods: The T24, J82 (both from human) and MB49 (from mouse) bladder tumour cell lines (3) were cultured at different multiplicities of infection (MOI) with BCG Pasteur-GFP or MTBVAC-GFP (these strains express the GFP constitutively). Percentage of infection and cell death at different time points were measured by Flow Cytometry. Additionally, we studied the localization and the basic characteristics of the organelles that contain the BCG or MTBVAC by the use of Confocal microscopy. Results: The study of percentage of infection shows a very significant increase in the case of MTBVAC vaccine at 96 hours and 7 days in contrast of the low percentages in BCG Pasteur-GFP. Moreover, the study of cell death by Flow Cytometry is in accordance with the observed results of infection. Finally, we have obtained images in which MTBVAC-GFP shows clearly their localization in the acid compartments of the cell inside while the BCG Pasteur-GFP are in not acidic organelles in the inner of the cell. The number of bacilli of MTBVAC-GFP in the inner of the any cell line of bladder cancer is significantly higher than BCG Pasteur-GFP and the integrity of the cells is worse, mainly at 7 days of infection. Conclusions: We show that our vaccine candidate MTBVAC is a promising potentially alternative to BCG in treatment of bladder cancer. References: 1. Brandau S, Suttmann H. Thirty years of BCG immunotherapy for non-muscle invasive bladder cancer: a success story with room for improvement. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2007;61(6):299-305. 2. Arbues A, Aguilo JI, Gonzalo-Asensio J, Marinova D, Uranga S, Puentes E, et al. Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials. Vaccine. 2013;31(42):4867-73. 3. Secanella-Fandos S, Luquin M, Julian E. Connaught and Russian strains showed the highest direct antitumor effects of different Bacillus Calmette-Guerin substrains. The Journal of urology. 2013;189(2):711-8.10th Meeting of Molecular Microbiology, Group Specializing in the Microbiology Spanish Society (SEM)., Segovia, Spain; 06/2014
Article: A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component[Show abstract] [Hide abstract]
ABSTRACT: The ESX-1 secreted virulence factor ESAT-6 is one of the major and most well-studied virulence factors of Mycobacterium tuberculosis given that its inactivation severely attenuates virulent mycobacteria. In this work we show that clinical isolates of M. tuberculosis produce and secrete higher amounts of ESAT-6 than the widely used M. tuberculosis H37Rv laboratory strain. A search for the genetic polymorphisms underlying this observation showed that whiB6 (rv3862c), a gene upstream of the ESX-1 genetic locus that has not previously been found to be implicated in the regulation of ESX-1 secretory apparatus, presents a unique single nucleotide insertion in its promoter region in strains H37Rv and H37Ra. This polymorphism is not present in any of the other publically available M. tuberculosis complex genomes or in any of the 76 clinical M. tuberculosis isolates analyzed in our laboratory. We demonstrate that in consequence, the virulence master regulator PhoP down-regulates whiB6 expression in H37Rv while it up-regulates its expression in clinical strains. Importantly, reintroduction of the wild-type (WT) copy of whiB6 in H37Rv restored ESAT-6 production and secretion to the level of clinical strains. Hence, we provide clear evidence that in M. tuberculosis - with the exception of the H37Rv strain - ESX-1 expression is regulated by WhiB6 as part of the PhoP regulon, which adds another level of complexity to the regulation of ESAT-6 secretion with a potential role in virulence adaptation.Infection and Immunity 06/2014; 82(8). DOI:10.1128/IAI.01824-14 · 4.16 Impact Factor
Article: A human dendritic cell-based in vitro model to assess Mycobacterium tuberculosis SO2 vaccine immunogenicity.[Show abstract] [Hide abstract]
ABSTRACT: Among the tuberculosis (TB) vaccine candidates, SO2 is the prototype of the first live-attenuated vaccine that recently entered into clinical trials. To investigate the capacity of SO2 to stimulate an appropriate immune response in vitro within a human immunological context, a comparative analysis of the effects promoted by SO2, the current Bacille Calmette-Guerin (BCG) vaccine and Mycobacterium tuberculosis (Mtb) was conducted in human primary dendritic cells (DC), which are critical modulators of vaccine-induced immunity. In particular, we found that SO2 promotes the expression of maturation markers similarly to BCG but at a lower extent than Mtb. Moreover, SO2-infected DC released higher levels of interleukin (IL)-23 than BCG-infected cells, which account for the expansion of interferon (IFN)-γ-producing T cells in an IL-12-independent manner. In the autologous mixed leukocyte reaction setting, the expansion of IL-17-producing T cells was also observed in response to SO2 infection. Interestingly, apoptosis and autophagic flux, events required for the antigen presentation within MHC class II complex, were not affected in DC infected with SO2, conversely to what observed upon Mtb stimulation. Collectively, our results indicate that SO2 represents a promising TB vaccine candidate, which displays an attenuated phenotype and promotes in DC a stronger capacity to stimulate the Th response than BCG vaccine. Interestingly, the data obtained by using the human DC-based experimental setting mirrored the results derived from studies in animal models, suggesting that this system could be used for an efficient and rapid down-selection of new TB vaccine candidates, contributing to achieve the "3Rs" objective.
Article: The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis.[Show abstract] [Hide abstract]
ABSTRACT: The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specific cell wall components and attenuation both ex vivo and in vivo. Using antibodies against the native protein in ChIP-seq experiments (chromatin immunoprecipitation followed by high-throughput sequencing) we demonstrated that PhoP binds to at least 35 loci on the M. tuberculosis genome. The PhoP regulon comprises several transcriptional regulators as well as genes for polyketide synthases and PE/PPE proteins. Integration of ChIP-seq results with high-resolution transcriptomic analysis (RNA-seq) revealed that PhoP controls 30 genes directly, whilst regulatory cascades are responsible for signal amplification and downstream effects through proteins like EspR, which controls Esx1 function, via regulation of the espACD operon. The most prominent site of PhoP regulation was located in the intergenic region between rv2395 and PE_PGRS41, where the mcr7 gene codes for a small non-coding RNA (ncRNA). Northern blot experiments confirmed the absence of Mcr7 in an M. tuberculosis phoP mutant as well as low-level expression of the ncRNA in M. tuberculosis complex members other than M. tuberculosis. By means of genetic and proteomic analyses we demonstrated that Mcr7 modulates translation of the tatC mRNA thereby impacting the activity of the Twin Arginine Translocation (Tat) protein secretion apparatus. As a result, secretion of the immunodominant Ag85 complex and the beta-lactamase BlaC is affected, among others. Mcr7, the first ncRNA of M. tuberculosis whose function has been established, therefore represents a missing link between the PhoPR two-component system and the downstream functions necessary for successful infection of the host.PLoS Pathogens 05/2014; 10(5):e1004183. DOI:10.1371/journal.ppat.1004183 · 8.14 Impact Factor
Article: Pulmonary BCG vaccination confers dose-dependent superior protection than subcutaneous vaccination.[Show abstract] [Hide abstract]
ABSTRACT: The BCG vaccine is one of the most widely used vaccines worldwide. However, it appears ineffective in preventing pulmonary tuberculosis. Here we show that pulmonary BCG vaccination of mice over a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared with subcutaneous vaccination.Clinical and vaccine Immunology: CVI 02/2014; DOI:10.1128/CVI.00700-13 · 2.37 Impact Factor
Article: Single nucleotide polymorphism (SNP) analysis used for the phylogeny of the Mycobacterium tuberculosis complex based on a pyrosequencing assay.[Show abstract] [Hide abstract]
ABSTRACT: Different polymorphisms have been described as markers to classify the lineages of the Mycobacterium tuberculosis complex. The analysis of nine single nucleotide polymorphisms (SNPs) was used to describe seven SNPs cluster groups (SCGs). We attempted to classify those strains that could not been categorized into lineages by the genotyping methods used in the routine testing. The M. tuberculosis complex isolates collected in 2010 in our region were analysed. A new method based on multiplex-PCRs and pyrosequencing to analyse these SNPs was designed. For the pyrosequencing assay nine SNPs that defined the seven SCGs were selected from the literature: 1977, 74092, 105139, 232574, 311613, 913274, 2460626, 3352929 and gyrA95. In addition, SNPs in katG463, mgtC182, Ag85C103 and RDRio deletion were detected. This work has permitted to achieve a better classification of Aragonian strains into SCGs and in some cases, to assign strains to its certain lineage. Besides, the description of a new pattern shared by two isolates "SCG-6c" reinforces the interest of SNPs to follow the evolution of M. tuberculosis complex.BMC Microbiology 02/2014; 14(1):21. DOI:10.1186/1471-2180-14-21 · 2.98 Impact Factor
Article: ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question[Show abstract] [Hide abstract]
ABSTRACT: The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis. This role has been supported by independent studies in which apoptosis has been shown as a hallmark feature in human and mouse lungs infected with virulent strains. Nevertheless, the role of apoptosis during mycobacterial infection is subject to an intense debate. Several works maintain that apoptosis is more evident with attenuated strains, whereas virulent mycobacteria tend to inhibit this process, suggesting that apoptosis induction may be a host mechanism to control infection. In this review, we summarize the evidences that support the involvement of ESX-1-induced apoptosis in virulence, intending to provide a rational treatise for the role of programmed cell death during M. tuberculosis infection.Frontiers in Cellular and Infection Microbiology 12/2013; 3:88. DOI:10.3389/fcimb.2013.00088 · 2.62 Impact Factor
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ABSTRACT: Substantial efforts have been made over the past decade to develop vaccines against tuberculosis. We review recent developments in tuberculosis vaccines in the global portfolio, including those designed for use in a prophylactic setting, either alone or as boosts to Bacille Calmette-Guérin, and therapeutic vaccines designed to improve chemotherapy. While there is no doubt that progress is still being made, there are limitations to our animal model screening processes, which are further amplified by the lack of understanding of the immunological responses involved and the precise type of long-lived immunity that new vaccines need to induce. The challenge ahead is to optimize the planning for advanced clinical trials in poor endemic settings, which could be greatly facilitated by identifying correlates of protection.Expert Review of Vaccines 12/2013; 12(12):1431-48. DOI:10.1586/14760584.2013.856765 · 4.22 Impact Factor
Article: Global Study of IS6110 in a Successful Mycobacterium tuberculosis Strain: Clues for Deciphering Its Behavior and for Its Rapid Detection[Show abstract] [Hide abstract]
ABSTRACT: The insertion sequence (IS) 6110, besides being a very useful tool in molecular epidemiology seems to have an impact on the biology of the bacillus. In the present work, we mapped and localized the 12 points of insertion of IS6110 in the genome of a successful strain named Mycobacterium tuberculosis Zaragoza "MTZ". This strain belonging to the principal genetic group 3 caused a large and unsuspected tuberculosis outbreak involving 85 patients in Zaragoza (Spain) from 2001 to 2004. The mapping of the points of insertion of IS6110 in the genome of MTZ strain offers clues for a better understanding of the adaptability and virulence of M. tuberculosis. Surprisingly, the presence of one copy of IS6110 was found in Rv2286c, as was recently described in a successful Beijing sub-lineage. As a result of this analysis, a rapid method for detecting this particular M. tuberculosis strain has been designed.Journal of clinical microbiology 08/2013; 51(11). DOI:10.1128/JCM.00970-13 · 4.23 Impact Factor
Article: Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials[Show abstract] [Hide abstract]
ABSTRACT: The development of a new tuberculosis vaccine is an urgent need due to the failure of the current vaccine, BCG, to protect against the respiratory form of the disease. MTBVAC is an attenuated Mycobacterium tuberculosis vaccine candidate genetically engineered to fulfil the Geneva consensus requirements to enter human clinical trials. We selected a M. tuberculosis clinical isolate to generate two independent deletions without antibiotic-resistance markers in the genes phoP, coding for a transcription factor key for the regulation of M. tuberculosis virulence, and fadD26, essential for the synthesis of the complex lipids phthiocerol dimycocerosates (DIM), one of the major mycobacterial virulence factors. The resultant strain MTBVAC exhibits safety and biodistribution profiles similar to BCG and confers superior protection in preclinical studies. These features have enabled MTBVAC to be the first live attenuated M. tuberculosis vaccine to enter clinical evaluation.Vaccine 08/2013; 31(42). DOI:10.1016/j.vaccine.2013.07.051 · 3.49 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Apoptosis modulation is a procedure amply utilized by intracellular pathogens to favour the outcome of the infection. Nevertheless, the role of apoptosis during infection with Mycobacterium tuberculosis, the causative agent of human tuberculosis, is subject of an intense debate and still remains unclear. In this work, we describe that apoptosis induction in host cells is clearly restricted to virulent M. tuberculosis strains, and is associated with the capacity of the mycobacteria to secrete the 6-kD early secreted antigenic target ESAT-6 both under in vitro and in vivo conditions. Remarkably, only apoptosis-inducing strains are able to propagate infection into new cells, suggesting that apoptosis is used by M. tuberculosis as a colonization mechanism. Finally, we demonstrate that in vitro modulation of apoptosis affects mycobacterial cell-to-cell spread capacity, establishing an unambiguous relationship between apoptosis and propagation of M. tuberculosis. Our data further indicate that BCG and MTBVAC vaccines are inefficient in inducing apoptosis and colonizing new cells, correlating with the strong attenuation profile of these strains previously observed in vitro and in vivo.Cellular Microbiology 07/2013; DOI:10.1111/cmi.12169 · 4.82 Impact Factor
Article: Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype[Show abstract] [Hide abstract]
ABSTRACT: Mycobacterium tuberculosis Beijing strains are characterized by a large number of IS6110 copies, suggesting the potential implication of this element in the virulence and capacity for rapid dissemination characteristic of this family. This work studies the insetion points of IS6110 in high-copy clinical isolates specifically focusing on the Beijing genotype. In the present work we mapped the insertion points of IS6110 in all the Beijing strains available in the literature and in the DNA sequence databases. We generated a representative primer collection of the IS6110 locations, which was used to analyse 61 high-copy clinical isolates. A total of 440 points of insertion were identified and analysis of their flanking regions determined the exact location, the direct repeats (DRs), the orientation and the distance to neighboring genes of each copy of IS6110. We identified specific points of insertion in Beijing strains that enabled us to obtain a dendrogram that groups the Beijing genotype. This work presents a detailed analysis of locations of IS6110 in high-copy clinical isolates, showing points of insertion present with high frequency in the Beijing family and absent in other strains.BMC Genomics 06/2013; 14(1):422. DOI:10.1186/1471-2164-14-422 · 4.04 Impact Factor
Top Journals
- PLoS ONE (5)
- Emerging infectious diseases (3)
- Journal of clinical microbiology (3)
- BMC Microbiology (3)
- Vaccine (2)
Centro de Investigacion Biomédica en Red de Enfermedades RespiratoriasBunyola, Balearic Islands, Spain
University of British Columbia - VancouverVancouver, British Columbia, Canada
University of Zaragoza
Caesaraugusta, Aragon, Spain
- • Department of Microbiology, Preventive Medicine and Public Health
- • Faculty of Medicine
University of Central Florida
Orlando, Florida, United States
- Graduate Program in Molecular Biology and Microbiology
National University of Colombia
Μπογκοτά, Bogota D.C., Colombia
- Departamento de Química (Bogotá)
Stellenbosch UniversityJohannesburg, Gauteng, South Africa
Universidad Autónoma de MadridMadrid, Madrid, Spain
Institut PasteurLutetia Parisorum, Île-de-France, France


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Systems integrator Dega Broadcast Systems has installed 100 Crystal Vision Indigo 2 frames as part of its ongoing project to provide central technical areas and infrastructure for the redevelopment of the BBC Broadcasting House in London. The 861,000fq-ft W1 broadcast center will be the new home of the BBC's national and international news operations as well as the national radio networks.
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An Inside Look at Four Virtual Reality Start-Ups
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BT Renews Intelsat Deal
Top Twitter TV Shows for 2014-15 Season Unveiled
comScore Introduces MobiLens Plus
North Korean Propoganda Art Inspires the Credits of 'The Interview'
Imaginary Forces Creates Kaleidoscopic Titles for 'Bosch'
Filmmaker Embraces Short Documentary Format with Oscar-Nominated 'Crisis Hotline'
North Metro Television Goes Wireless with Comrex LiveShot
Spectra Logic and HauteSpot Networks Introduce Body-Worn Camera Video Surveillance Solution
Huge Ultra HD Display Lights Up Times Square


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VIEWS: 11 PAGES: 1 CATEGORY: Business POSTED ON: 11/14/2010 Public Domain
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How to Make a Camera-Ready for ISSS'07 First Surname1 (email address), Second Surname2 (email), Third Surname3 (email) 1 School of Computer and Cognitive Sciences, Chukyo University, Japan 2 Graduate School of Media and Governance, Keio University, Japan 3 Japan Advanced Institute of Science and Technology, Japan Abstract Schon, D. A., & Wiggins, G. (1992). Kinds of seeing and their functions in designing. Design Studies, 13(2), 135- The abstract should be one paragraph, indented 3.2mm on 156. both sides, in 9 point font with 10 point vertical spacing. The Suwa, M., & Tversky, B. (2003). Constructive perception: heading Abstract should be 10 point, bold, centered, with one A meta-cognitive skill for coordinating perception and line space below it. conception. Proceedings of the Twenty-fifth Annual Conference of the Cognitive Science Society (pp. 1140- General Formatting Instructions 1144). Hillsdale, NJ: Erlbaum. The text of the paper should be formatted in two columns with an overall width of 17.8 cm and length of 23.5 cm, with 0.63 cm between the columns. Leave two line spaces between the last author listed and the text of the paper. The left and right margin should be 1.9 cm, and the top and bottom margin should be 2.5cm. Please select page setting to A4 paper. Use 10 point Times Roman with 11 point vertical spacing. First-Level Headings First-level headings should be 12 point, initial caps, bold and centered. Leave one line space above the heading and 1/4 line space below the heading. Second-Level Headings Second-level headings, if needed, should be 11 point, initial caps, bold, and flush left. Leave 1/2 line space above and 1/4 line space below the heading. Formalities, Footnotes, and Floats Use standard APA citation format (e.g., McClelland & Rumelhart, 1981; Richman & Simon, 1989). Use the et al. construction for the 2nd reference to paper or for citations with four or more authors. Number tables consecutively; place the table number and title (in 10 point) above the table with one line space above Acknowledgments Place acknowledgments (including funding information) in a section at the end of the paper. References Greeno, J. G. (1989). Situations, mental models and generative knowledge. In D. Klahr & K. Kotovsky (eds.), Complex information processing: The impact of Herbert A. Simon. Hillsdale, NJ: Erlbaum. Mazzoni, G., & Nelson, T. O. (Eds.) (1998). Meta-cognition and cognitive psychology, monitoring and control processes. NJ: Lawrence Erlbaum Associates. Newell, A., & Simon, H. A. (1972). Human problem solving. Englewood Cliffs, NJ: Prentice-Hall. ll.
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text: Miley calls Jennifer Lawrence a LIAR Fri-23-May-14 15:42 Share this Tell Us What You Think WTF 0 LOL 0 FAIL 0 OMG 0 HOT 0 CUTE 0 ] By Sharyn CaseyRemember when I told you about how JLaw said in an interview that she spewed on the steps at Madonna's party & Miley walked past and said "get it together girl". Well Miley has come out and said on Twitter that it NEVER HAPPENED. Miley deleted the tweet shortly after posting but not before fans grabbed a screenshot of it. You May Also Like Jay-Jay, Mike & Dom wreck Miley's 'Wrecking Ball' Countless celebs exposed in HUGE nude photo leak Jennifer Lawrence gets photoshopped Become a fan of The Edge on Facebook and on Twitter .


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Non-perishable food is food that does not spoil and has a long shelf life. It is considered a staple food to have in the pantry, as it does not spoil for a very long time and can be used for many years.
Most non-perishable foods are canned or boxed foods, as these are packaged to last on the shelf for a long time. It is a good idea to have these foods in the pantry just in case the power goes out or there is another situation where fresh food is not accessible. Examples of non-perishable foods include canned vegetables and fruit, pasta, whole grain rice, high fiber cereal, canned tuna or chicken, peanut butter and canned beans.
Non-perishable food does not rot or decay without refrigeration. Canned goods, flour, dry cereals, candy, and sugar are examples of non-perishable foods.
1. Place a self-adhesive gift bow on top of each can of food. This will make the cans easier to see in the basket and add a special touch. 2. Fill the basket with canned foods. Put
Consider MRE meals. (Meals ready to eat. The military uses them to provide for soldiers in the field. They last forever (sealed in packets) and require almost no prep except water.
Some non-perishable foods are canned foods, such as green beans, peaches and pineapple and dehydrated fruit such as apricots and bananas.