text:
Continental Cream Cheese Slice
5 Sep 2010
|Plain flour
|6 Ounce
|Custard powder
|2 Ounce
|Icing sugar
|3 1⁄4 Tablespoon (4 Dessertspoons)
|Baking powder
|1⁄2 Teaspoon
|Butter milk
|4 Ounce
|2 Ounce
|1 , rind grated
|Lemon juice
|1 1⁄2 Tablespoon (2 Dessertspoons)
Pastry Sift into basin the flour, custard powder, icing sugar and baking powder.
Rub in butter, add sufficient milk to make into a stiff dough Roll out § of the pastry and line 7 in. x 11 in. greased tin, bringing pastry 1/2 inch up the sides.
Prick base and bake in moderate oven, Mark 4,350°F., 10 minutes; cool.
Filling Cream butter with cream cheese until soft and creamy.
Beat eggs and sugar until light and fluffy.
Gradually add to cream cheese mixture, beat until smooth.
Fold in sultanas, lemon rind, and juice.
Smooth filling over cooked pastry shell.
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Continental Cream Cheese Slice Recipe


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Hornish will share Kyle Busch's Nationwide ride part-time (UPDATED)
Jan 6, 2014, 12:10 PM EDT
UPDATE, 12:10 p.m. ET: Make that "potentially" below an "actually." Sam Hornish Jr. will run at least seven races in the No. 54 Joe Gibbs Racing Toyota in the NASCAR Nationwide Series, the team announced Monday.
Hornish will race at Talladega, both races at the now-NASCAR owned Iowa Speedway, Road America, Chicago, Mid-Ohio and Kentucky.
Sam Hornish Jr. won his second career NASCAR Nationwide Series race and finished second in this year's championship, but despite his efforts for Penske Racing, the team was unable to secure enough sponsorship for him to continue in that seat into 2014.
So, potentially, he could join Joe Gibbs Racing in a ride-share with Kyle Busch in the No. 54 Toyota. Lee Spencer of FOXSports.com reports sources say he will.
Hornish, who has spent the last 10 years of his career with Penske, four years in IndyCar (2004-2007) and the last six in NASCAR (2008-2013), is at something of a career crossroads. He has certainly demonstrated the skills and put together the results in Nationwide over the last couple years to merit a return to the Sprint Cup ranks.
But, as several mid-field Cup contenders have found, the path back to Cup can include a detour to Nationwide. Besides Hornish, drivers like Elliott Sadler, Regan Smith and Brian Vickers stand out over the last few years. Vickers will make his Cup return with Michael Waltrip Racing for 2014. The Cup field is filled with more Nationwide graduates than in recent years, but they're all drivers set for their first full Cup seasons (series champion Austin Dillon, Kyle Larson, Parker Kligerman, Michael Annett among others).
Winning in a part-time situation with what would arguably be one of the best cars on the Nationwide grid – one that won 12 times in Busch's hands in 2013 – can only boost Hornish's stock. But it's unfortunate that the sponsorship situation is such that this is all Hornish appears likely to race in 2014.
- manik56 - Jan 6, 2014 at 9:44 PM
It may not be a full ride, but at least I get to cheer Sam on at Mid-Ohio. It is a shame the Cup regulars are still allowed to ruin what could be a great series.
- garsam2014 - Jan 11, 2014 at 7:51 PM
Not so sure Klingerman or Annett have what it takes to run cup. Of course it's not always about talent now. Money talks in racing.
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Cultural Historian Jacques Barzun Dies At 104
Jacques Barzun, one of the most influential historians, educators and thinkers of the 20th century, died Thursday, just one month shy of his 105th birthday. Barzun seemed to have a limitless capacity to understand and translate complex ideas — about the evolution of Western culture, what it means to be free, and even the value of American baseball. He shared his observations in numerous books and magazine articles and at Columbia University, where he held forth for half a century.
In an interview 12 years ago on All Things Considered, Barzun said he believed history is driven by emancipation. "It is getting rid of whatever constraint at the moment seems intolerable," he said, "that of class, government — and now it seems to be against clothing."
If that smacks of a kind of intellectual get-off-my-lawn-ism, well, Barzun was a thinker of uncompromisingly high standards and some degree of sarcasm. He was born in Paris, the son of a diplomat. French universities had been decimated by World War I, so he attended Columbia in New York. Barzun taught there the summer after graduating and helped design its Great Books program; he later lamented that his approach was disappearing from universities....
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Fedora 18 For ARM Officially Released
Published on 05 February 2013 10:25 AM EST
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Michael Larabel
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One month after
Fedora 18
was released for x86/x86_64 hardware, the "Spherical Cow" is now officially available for select ARM-based devices.
Fedora 18 ARM is officially available with pre-built images for the Versatile Express (QEMU), Trimslice (Tegra), Pandaboard (OMAP4), GuruPlug (Kirkwood), and Beagleboard (OMAP3). It's also easy to load up Fedora 18 on Calxeda's HighBank EnergyCore and other select ARM systems. With the popular Raspberry Pi being an ARMv6 product and not ARMv7, there is no official image available of Fedora but some remixes are offered independently.
Fedora 18 ARM images can be found
. The Fedora 18 ARM release announcement is hosted on
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The Pyle Pro PCO820 Rack Mounted Power Conditioner features 8 outlets, that can support up to 4 wall warts. Its triple mode Varisitor Surge & Spike Protection protects your gear from inadvertent electrical spikes and surges. The front panel features a 2-digit LED that displays incoming AC line voltage. Two pull-out lights are features on the front.
- Triple Mode Varistor Surge And Spike Protection
- Eight Rear Outlets (With Room For 4 'Wall Warts') Controlled By A Front Panel Switch
- 15 Amp Rating (1800 W) With Rear Panel Circuit Breaker (UL)
- Two Added Front Panel Slide-Out, Swiveling Lights For Rack
- Illumination And Dimmer Controls To Adjust Lamp Brightness
- Large LED Numeric Meter That Displays Incoming AC Line Voltage And 2 Voltage
- Condition Indicators Standard Voltage And Over Voltage
- Rugged Single Rack Space Metal Housing For Maximum Reliability


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Device APIs in the Real World
by Tim Murtaugh ·
Article Continues Below
In his A List Apart article Environmental Design with the Device API, Tim Wright proposed taking user experience to the next level by creating applications that pay attention to changes in the physical environment and respond accordingly. As a follow-up to that article, Tim has put together a quick video demonstrating the ambient light detection capabilities of the Nexus 7.
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42 year old woman | Austin, TX, USA | Seeking women 33-52 within 25 miles
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Looking for smiles
I am hoping to meet someone to share some good times with. I want to have great conversations and have some new experiences. I am confident and comfortable with who I am, and the woman I am looking for would be as well. My preference is for women who are feminine to tomboyish I like to do yoga and read but I am also adventurous and like trying new things. Through my struggles I have developed a deep respect and passion for life. I love the life I am living! I want someone that shares a passion for people and enjoys their life too. Not every day, I have my moments, I'm human, but overall I'm happy and want people in my life who are also positive and joyful. Someone who wants to travel and experience life, meet the struggles and grow. And you must love puppies! I have an awesome German shepherd no one could resist.
Coffee and conversation , Cooking , Dining out , Museums and art , Exploring new areas , Playing sports , Travel/Sightseeing , Wine tasting
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text:
Stephen Hayes reviews the selective leaking of the memos on enhanced interrogation techniques and the comments from Vice President Cheney that there is more evidence out there of benefits we derived from them than the Obama team is revealing. Hayes writes:
It is possible, I suppose, that a series of fortunate coincidences has resulted in the public disclosure of only that information that will be politically helpful to the Obama administration. It is also possible that Dick Cheney has taken up synchronized swimming in his retirement.
The danger here for the Obama administration is three-fold. First, the press has begun a feeding frenzy: Why did the administration change position on prosecution? Why the selective leaks? Even if sympathetic to the decision itself, nothing gets the White House press corps going like a game-playing bit of media deception. And they now have a big juicy story on that front.
Second, a high stakes hyper-partisan battle complete with leaking memos and an aggrieved CIA contingent is likely the last thing the Obama administration needs. This is the Church Committee on steroids — a national angst festival where one side will make the case that by lighting the match the president has hobbled our national security apparatus. So much for No-Drama Obama.
Finally, it is hard not to conclude that the Bush administration will come out looking better at the end of this, and its critics, worse. A planned attack on Los Angeles — what would you do? A congressional contingent visits the detention center, queries the officials to make sure we're doing "enough" and now convenes the witch hunt. How's that going to look?
This is, as Hayes writes in understated terms, one "odd" episode in American history. The oddest perhaps yet. No administration before has declared war on its predecessor, and for good reason: you can't do it without tearing the country and our national security apparatus apart. For someone pledging to be post-partisan and to avoid destructive recriminations, Obama has chosen a very "odd" course. He has done more to criminalize politics than any single figure in American history — no easy feat for someone in office less than one hundred days.


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You all probably know the famous actrice Katherine Marie Heigl!! He played in a lot of movies. Now she was invited to a charity even and she needs to find the perfect hairstyle and a gorgeous make up to go with her outfit! What do you say? Show her your artistic skills and make Katherine look amazing for the event! For sure she will love your work, so start preparing her for the event! Enjoy this amazing make up game!
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text:
Proveblue®, a methylene blue dye that complies with European Pharmacopoeia and contains limited organic impurities and heavy metals of recognized toxicity, showed in vitro synergy against Plasmodium falciparum when combined with atorvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase. The objective of this study was to evaluate the in vivo efficacy of Proveblue® when combined with atorvastatin in a murine model of experimental cerebral malaria.
Forty female C57Bl6/N mice were divided into four groups (control, atorvastatin 40 mg/kg for seven days, Proveblue® 10 mg/kg for five days and atorvastatin combined with Proveblue®), infected with Plasmodium berghei ANKA parasites by intraperitoneal inoculation and observed for 45 days.
Treatment with atorvastatin alone did not demonstrate an effect significantly different from no treatment (p = 0.0573). All the mice treated by atorvastatin alone died. Treatment with Proveblue® or a combination of Proveblue® and atorvastatin was significantly increased survival of cerebral malaria (p = 0.0011 and 0.0002, respectively). Although there was only one death in the atorvastatin and Proveblue® combination treatment group (10%) versus two deaths (22%) with Proveblue® treatment, the effect on cerebral malaria was not significant (p = 0.283).
The present work demonstrated, for the first time, the high efficacy of Proveblue® in preventing cerebral malaria. Atorvastatin alone or in combination appears to possess limited use for preventing cerebral malaria. Combination of atorvastatin with lower doses of Proveblue® (<10 mg/kg/day) should be evaluated to show potential synergistic effects in cerebral malaria prevention.
Keywords:Malaria; Plasmodium; Anti-malarial drug; in vivo; Resistance; Methylene blue; Atorvastatin
In 2002, the World Health Organization (WHO) recommended that artemisinin-based combination therapy (ACT) should be used for all cases of uncomplicated malaria. Four years later, the WHO further recommended that artesunate should be deployed as the first-line treatment for severe malaria in adults and replace quinine due to its efficacy and better tolerance [1]. In 2010, a large-scale trial confirmed the potency of artesunate for treating severe malaria in children [2]. In 2011, WHO recommended artesunate as the first-line treatment for severe malaria. Several recent studies have reported clinical failures or extended parasite clearance times in Cambodia [3-5].
There is an urgent need for the discovery of new anti-malarial drugs and combination therapy. A combinatorial approach protects each drug from the development of resistance and reduces the overall transmission rate of malaria [6].
Methylene blue (MB) is an old anti-malarial drug that is no longer in use. In 1891, Guttmann and Ehrlich were the first to report the anti-malarial properties of a synthetic thiazine dye, methylene blue, when they described the clinical cure of two patients after oral administration of MB [7]. Cardamatis wrote in Progrès Médical that he had found MB to be very effective in the early stages of severe malaria cachexia in cases that were resistant to quinine [8]. MB has shown in vitro activity against Plasmodium falciparum strains [9,10] or isolates [11,12] and in vivo activity against Plasmodium vinckei and Plasmodium yoelii parasites [13,14].
Currently, there is no MB available globally that complies with European Pharmacopoeia. To date, the pharmaceutical use of MB has been stymied by contamination with organic impurities and heavy metals with recognized toxicity. Provence Technologies and its subsidiary, Provepharm, have conducted four years of research that resulted in the first European Pharmacopoeia-grade MB: Proveblue®. This drug was obtained from an innovative synthetic and heavy-metal-free pathway using pharmaceutical-grade reagents (patent application N°FR06/06330, which has been extended to the international PCT reference PCT/FR/2007/001193). The total concentration of metals, Azure B (the most important impurity in MB) and other impurities in Proveblue® is <20 ppm, <2%, <0.5%, respectively. Proveblue® has in vitro anti-malarial activity (mean IC50 = 3.62 nM) against 23 P. falciparum strains that are resistant to other anti-malarial drugs [15]. No significant association was found between the Proveblue IC50 and polymorphisms in the genes that are involved in quinoline resistance, such as pfcrt, pfmdr1, pfmdr2, pfmrp and pfnhe-1; furthermore, there is no significant association between the Proveblue IC50 and the copy numbers of pfmdr1 and pfmdr2[15]. While Proveblue® has in vitro antagonistic effects when combined with chloroquine and additive effects when combined with desethylamodiaquine against nine P. falciparum strains, Proveblue® exhibited noticeable synergistic effects when combined with mefloquine and quinine and high synergistic effects when combined with dihydroartemisinin, the active metabolite of artemisinin derivatives [16].
Statins, the inhibitors of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMG-CoA reductase) and a family of lipid-lowering drugs, have in vitro anti-malarial properties [17,18]. Atorvastatin (AVA), like the other statins, is not a highly active blood schizonticidal anti-malarial drug with IC50 values ranged from 2.5 to 12 μM [17,18]. Its application in malaria chemotherapy would be for adjuvant treatment. Moreover, AVA improved the in vitro activity of mefloquine [19], quinine [20], dihydroartemisinin [21] and Proveblue® [16] at the plasma concentrations expected in clinical observations in patients taking 80 mg of AVA daily (0.1 to 0.5 μM) [22]. However, AVA used alone failed to prevent death from cerebral malaria or to affect the parasitaemia of infected mice [23]. AVA combined with mefloquine led to a significant delay in mouse death and had an effect on the onset of cerebral malaria symptoms [24].
The objective of the present work was to evaluate the in vivo efficacy of Proveblue® when combined with AVA in a murine model of experimental cerebral malaria. While animal models do not exactly reproduce human malaria, they nevertheless exhibit some similarities to human cerebral malaria, and the Plasmodium berghei ANKA rodent parasite model is generally accepted as valid for studying experimental cerebral malaria pathogenesis [25,26].
Mice and experimental cerebral malaria
Forty female C57Bl6/N mice, six to seven weeks old and weighing 18–22 g (Charles Rivers, France), were infected on day 0 (D0) with P. berghei ANKA parasites by intraperitoneal (ip) inoculation. The inoculum contained 105 parasitized erythrocytes extracted from infected donor C57Bl6/N mice and diluted in 200 μl normal saline. All animals were pathogen-free and were housed under standard conditions, with unlimited access to food and water. All efforts were made to minimize animal suffering. All experiments adhered to French guidelines for animal research and were approved by the ethical committee of the Institut de Recherche Biomédicale des Armées - Antenne de Marseille (Number 2007–09).
Except for the control group (8 mice), mice were treated daily when parasitaemia reached 0.1% by ip injection with 40 mg/kg AVA for seven days (7 mice), 10 mg/kg Proveblue® for five days (9 mice) or 40 mg AVA for seven days combined with 10 mg/kg Proveblue® during five days (10 mice). AVA calcium salt was dissolved in 1% dimethyl sulfoxyde (vol/vol) in 0.9% NaCl. The solution of 1% dimethyl sulfoxyde (vol/vol) in 0.9% NaCl was ip administered to control mice (after previously evaluation of absence of effect in infected and non-infected mice in comparison with 0.9% NaCl). Proveblue® was dissolved in 0.9% NaCl.
Parasitaemia was determined daily using Giemsa-stained thin blood smears collected from the tail vein. Parasitaemia was calculated by the number of infected red blood cells per 3,000 erythrocytes if >1% cells were infected and per 10,000 erythrocytes if <1% cells were infected. The animals were under daily supervision for clinical signs, neurological symptoms and weight. Experimental cerebral malaria was diagnosed by clinical signs based on a simplified SHIRPA protocol [27] with at least two symptoms in at least two of the three different groups: 1) alteration of autonomous function (piloerection, defecation, urination, respiration rate); 2) alteration of muscle tone and strength (grip strength, body tone, limb tone, abdominal tone); and, 3) ataxia, paralysis (mono-, hemi-, para-, or tetraplegia), deviation of the head, convulsions and coma.
Statistical analysis
The data were analysed using R software® (version 2.10.1). Survival analyses were performed by the Kaplan-Meier log rank test. The comparison of medians between multiple groups was analysed by the Kruskal-Wallis test. The comparison of medians between two groups was analysed by the Mann–Whitney test. A difference was considered significant when P-values were less than 0.05.
In the control group, all the mice died before D10, with specific signs of cerebral malaria and parasitaemia <10.5% (6.7-10.5%) (Figure 1). The mice treated with 40 mg/kg AVA died between D5 and D9 (29% of the experimental group) with specific cerebral malaria symptoms and parasitaemia (5.7-6.8%) or between D18 and D24 with anaemia and parasitaemia (94.2-98.4%). In the group of mice treated with 10 mg/kg Proveblue®, one mouse (11%) had recurrent parasites at D5 and died at D16 (50.0% parasitaemia), and another had recurrent parasites at D11 and died at D25 (91.7% parasitaemia). These two mice died with no specific signs of cerebral malaria. After two days of treatment with Proveblue®, no parasite was detectable by blood smear. At D45, the surviving mice had no parasites. In the group of mice treated with 40 mg/kg AVA combined with 10 mg/kg Proveblue®, one mouse (10%) had recurrent parasites at D10 and died at D14 (6.6% parasitaemia) with specific signs of cerebral malaria. At D45, the surviving mice had no parasites.
Figure 1. Survival curve of C57Bl6/N mice infected on day 0 (D0) with Plasmodium berghei ANKA parasites and treated with 40 mg/kg atorvastatin (AVA) for seven days, 10 mg/kg Proveblue® for five days or 40 mg atorvastatin for seven days combined with 10 mg/kg Proveblue® for five days.
Treatment with AVA alone did not demonstrate an effect significantly different from no treatment (p = 0.0573). All the mice treated by AVA alone died. These results confirm that in an experimental cerebral malaria model, therapeutic ip AVA treatment, similar to other statins, shows no effect on the incidence of cerebral malaria [23,24,28,29]. The pathogenesis of cerebral malaria in the murine model relies solely on the inflammatory response, unlike the pathogenesis of human cerebral malaria. Indeed, the cytoadherence phenomenon does not exist in P. berghei mice infections [30,31]. AVA strongly protects endothelial cell against P. falciparum-induced collateral damages, cell apoptosis and endothelial barrier permeabilization [32]. AVA can be used to reduce P. falciparum cytoadherence to endothelial cells; cytoadherence and the inflammatory burst are the key events of pathogenesis in severe human malaria. In mice with P. berghei ANKA cerebral malaria, lovastatin reduces pro-inflammatory cytokines in the brain and prevents cognitive impairment [33].
Treatment with Proveblue®, or a combination of Proveblue® and AVA, significantly reduced or prevented cerebral malaria (p = 0.0011 and 0.0002, respectively). A Proveblue® regimen of 10 mg/kg resulted in a 75% survival rate. This dosage is safe in children treated with methylene blue that was non-compliant with the European Pharmacopoeia [34,35]. Methylene blue at doses ranged from 12 mg/kg/day to 24 mg/kg/day for three days were administered to children with uncomplicated malaria in Burkina-Faso. Only one mouse died in the AVA and Proveblue® combination treatment group. The combination of Proveblue® and AVA was more effective than AVA alone in the experimental cerebral malaria mouse model (p = 0.0012). Although there was only one death with AVA plus Proveblue® treatment (10%) versus two deaths (22%) with Proveblue® alone, the effect on cerebral malaria was not significant (p = 0.283). Thus, the efficacy of the combination may be due to the effect of Proveblue®, not as a result of a synergism between the two compounds. The dose of 10 mg/kg of Proveblue® for five days, which showed a high efficacy when used alone, seems to be too high to show synergistic effects in combination with AVA. Combination with lower doses of Proveblue® should be evaluated. Proveblue® or AVA plus Proveblue® treatments are more effective than AVA and mefloquine combinations, which can delay mouse death and/or the onset of cerebral malaria but do not prevent death by anaemia [24]. The role of AVA in inhibiting cytoadherence in humans is not evaluable in mice, as this phenomenon does not exist in the P. berghei murine malaria model.
For the first time, the present work demonstrated the high efficacy of Proveblue® in preventing cerebral malaria. Another advantage of Proveblue® as an anti-malarial drug is that MB inhibits the maturation and transmission of gametocytes [36-38]. Of 44 compounds provided by Medicines for Malaria Venture, MB was the most active compound and reduced gametocyte viability with an IC50 value of 12 nM [39]. These results confirm the therapeutic potential of Proveblue®, a new MB formulation with limited organic impurities and toxic heavy metals that could be integrated into the pipeline of anti-malarial combination therapy [40]. AVA alone appears to possess limited use for preventing cerebral malaria. However, Proveblue® and AVA have different and complementary properties (effects on asexual stages, gametocyte maturation and transmission, cytoadherence, and pro-inflammatory cytokine levels), which makes them interesting partners for future investigation using combination therapy. Combination of AVA with lower doses of Proveblue® should be evaluated to show potential synergistic effects in cerebral malaria prevention. The present work demonstrated the high efficacy of Proveblue® in preventing cerebral malaria. The efficacy of Proveblue® and combination of AVA and Proveblue® should be evaluated in treating murine cerebral malaria.
Competing interests
All authors declare that they have no potential conflicts of interest.
Authors' contributions
JD and CD carried out the in vivo study. SB and BP conceived and coordinated the study. JD and SB analysed the data. JD and BP drafted the manuscript. All the authors read and approved the final manuscript.
This study was supported by the Délégation Générale pour l'Armement (grant no PDH-2-NRBC-4-B1-402).
Dondorp A, Nosten F, Stepniewska K, Day N, White N, South-East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) group: Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.
Lancet 2005, 366:717-735. PubMed Abstract | Publisher Full Text
Dondorp AM, Fanello CI, Hendriksen ICE, Gomes E, Seni A, Chhaganlal KD, Bojang K, Olaosebikan R, Anunobi N, Maitland K, Kivaya E, Agbenyega T, Blay Nguah S, Evans J, Gesase S, Kahabuka C, Mtove G, Nadjm B, Deen J, Mwanga-Amumpaire J, Nansumba M, Karema C, Umulisa N, Uwimana A, Mokuolu OA, Adedoyin OT, Jonhson WBR, Tshefu AK, Onyamboko MA, Sakulthaew T: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.
Lancet 2010, 376:1647-1657. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM: Evidence of artemisinin-resistant malaria in western Cambodia.
N Engl J Med 2008, 359:2619-2620. PubMed Abstract | Publisher Full Text
Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwrong M, Chotivanish K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NPJ, Lindegardh N, Socheat D, White NJ: Artemisinin resistance in Plasmodium falciparum malaria.
N Engl J Med 2009, 361:455-467. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Amaratunga C, Sreng S, Suon S, Phelps ES, Stepniewska K, Lim P, Zhou C, Mao S, Anderson JM, Lindegardh N, Jiang H, Song J, Su XZ, White NJ, Dondorp AM, Anderson TCJ, Fay MP, Mu J, Duong S, Fairhurst RM: Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study.
Lancet Infect Dis 2012, 12:851-858. PubMed Abstract | Publisher Full Text
White NJ: Preventing antimalarial drug resistance through combinations.
Guttmann P, Ehrlich P: Ueber die wirkung des methylenblau bei malaria.
Anonymous: Methylene blue in grave malaria cachexia.
Akoachere M, Buchholz K, Fischer E, Burhenne J, Haefeli WE, Schirmer RH, Becker K: In vitro assessment of methylene blue on chloroquine-sensitive and –resistant Plasmodium falciparum strains reveals synergistic action with artemisinins.
Antimicrob Agents Chemother 2005, 49:4592-4597. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Garavito G, Bertani S, Rincon J, Maurel S, Monje MC, Landau I, Valentin A, Deharo E: Blood schizontocidal activity of methylene blue in combination with antimalarials against Plasmodium falciparum.
Parasite 2007, 14:135-140. PubMed Abstract
Ademowo OG, Nneji CM, Adedapo ADA: In vitro antimalarial activity of methylene blue against field isolates of Plasmodium falciparum from children in Southwest Nigeria.
Indian J Med Res 2007, 126:45-49. PubMed Abstract
Okombo J, Kiara SM, Mwai L, Pole L, Ohuma E, Ochola LI, Nzila A: Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.
Antimicrob Agents Chemother 2012, 56:1105-1107. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Atamna H, Krugliak M, Shalmiev G, Deharo E, Pescarmona G, Ginsburg H: Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P. vinckei petteri and P. yoelii nigeriensis in vivo.
Biochem Pharmacol 1996, 51:693-700. PubMed Abstract | Publisher Full Text
Garavito G, Bertani S, Quiliano M, Valentin A, Aldana I, Deharo E: The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.
Mem Inst Oswaldo Cruz 2012, 107:820-823. PubMed Abstract | Publisher Full Text
Pascual A, Henry M, Briolant S, Charras S, Baret E, Amalvict R, Huyghues des Etages E, Feraud M, Rogier C, Pradines B: In vitro activity of Proveblue (Methylene Blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs.
Antimicrob Agents Chemother 2011, 55:2472-2474. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Dormoi J, Pascual A, Briolant S, Amalvict R, Charras S, Baret E, Huyghues des Etages E, Feraud M, Pradines B: Proveblue (Methylene Blue) as antimalarial agent: In vitro synergy with dihydroartemisinin and atorvastatin.
Antimicrob Agents Chemother 2012, 56:3467-3469. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Pradines B, Torrentino-Madamet M, Fontaine A, Henry M, Baret E, Mosnier J, Briolant S, Fusai T, Rogier C: Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum.
Antimicrob Agents Chemother 2007, 51:2654-2655. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Parquet V, Briolant S, Torrentino-Madamet M, Henry M, Almeras L, Amalvict R, Baret E, Fusai T, Rogier C, Pradines B: Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria.
Antimicrob Agents Chemother 2009, 53:2248-2252. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Wurtz N, Briolant S, Gil M, Parquet V, Henry M, Baret E, Amalvict R, Almeras L, Rogier C, Pradines B: Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene.
J Antimicrob Chemother 2010, 65:1387-1394. PubMed Abstract | Publisher Full Text
Parquet V, Henry M, Wurtz N, Dormoi J, Briolant S, Gil M, Baret E, Amalvict R, Rogier C, Pradines B: Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum.
Malar J 2010, 9:139. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Savini H, Souraud JB, Briolant S, Baret E, Amalvict R, Rogier C, Pradines B: Atorvastatin as a potential antimalarial drug: in vitro synergy in combinational therapy with dihydroartemisinin.
Antimicrob Agents Chemother 2010, 54:966-967. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Borek-Dohalsky V, Huclova J, Barrett B, Nemec B, Ulc I, Jelinek I: Validated HPLC-MS-MS method for simultaneous determination of atorvastatin and 2-hydroxyatorvastatin in human plasma-pharmacokinetic study.
Anal Bioanal Chem 2006, 386:275-285. PubMed Abstract | Publisher Full Text
Bienvenu AL, Picot S: Statins alone are ineffective in cerebral malaria but potentiate artesunate.
Antimicrob Agents Chemother 2008, 52:4203-4204. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Souraud JB, Briolant S, Dormoi J, Mosnier J, Savini H, Baret E, Amalvict R, Soulard R, Rogier C, Pradines B: Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model.
Malar J 2012, 11:13. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Lou J, Lucas R, Grau GE: Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans.
Clin Microbiol Rev 2001, 14:810-820. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Delahaye NF, Coltel N, Puthier D, Barbier M, Benech P, Joly F, Iraqi FA, Grau GE, Nguyen C, Rihet P: Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice.
BMC Genomics 2007, 8:452. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Lackner P, Beer R, Heussler V, Goebel G, Rudzki D, Helbok R, Tannich E, Schmutzhard E: Behavioural and histopathological alterations in mice with cerebral malaria.
Neuropathol Appl Neurobiol 2006, 32:177-188. PubMed Abstract | Publisher Full Text
Helmers AJ, Gowda DC, Kain KC, Liles WC: Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages.
Am J Trop Med Hyg 2009, 81:631-637. PubMed Abstract | Publisher Full Text
Kobbe R, Schreiber N, May J, Jacobs T: Simvastatin treatment shows no effect on the incidence of cerebral malaria or parasitemia during experimental malaria.
Antimicrob Agents Chemother 2008, 52:1583-1584. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Lackner P, Beer R, Helbok R, Broessner G, Engelhardt K, Brenneis C, Schmutzhard E, Pfaller K: Scanning electron microscopy of the neuropathology of murine cerebral malaria.
Malar J 2006, 5:116. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
White NJ, Turner GD, Medana IM, Dondorp AM, Day NP: The murine cerebral malaria phenomenon.
Trends Parasitol 2010, 26:11-15. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Taoufiq Z, Pino P, N'Dilimabaka N, Arrouss I, Assi S, Soubrier F, Rebollo A, Mazier D: Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage.
Malar J 2011, 10:52. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Reis PA, Estato V, da Silva TI, D'Avila JC, Siqueira LD, Assis EF, Bozza PT, Bozza FA, Tibiriça EV, Zimmerman GA, Castro-Faria-Neto HC: Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria.
PLoS Pathog 2012, 8:1003099. Publisher Full Text
Coulibaly B, Zoungrana A, Mockenhaupt FP, Schirmer RH, Klose C, Mansmann U, Meissner P, Müller O: Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: A randomized controlled trial.
Plos One 2009, 4:5318. Publisher Full Text
Meissner PE, Mandi G, Coulibaly B, Witte S, Tapsoba T, Mansmann U, Rengelshausen J, Schiek W, Jahn A, Walter-Sack I, Mikus G, Burhenne J, Riedel KD, Schirmer RH, Kouyaté B, Müller O: Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine.
Malar J 2006, 5:84. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Adjalley SH, Johnston GL, Li T, Eastman RT, Ekland EH, Eappen AG, Richman A, Sim BK, Lee MC, Hoffman SL, Fidock DA: Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.
Proc Natl Acad Sci USA 2011, 108:1214-1223. Publisher Full Text
Lelièvre J, Almeda MJ, Lozano S, Miguel C, Franco V, Leroy D, Herreros E: Activity of clinical relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence transmission blocking assay.
PLoS One 2012, 7:35019. Publisher Full Text
Kasozi DM, Gromer S, Adler H, Zocher K, Rahlfs S, Wittlin S, Fritz-Wolf K, Schirmer RH, Becker K: The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue.
Redox Rep 2011, 16:154-165. PubMed Abstract | Publisher Full Text
Peatey CL, Leroy D, Gardiner DL, Trenholme KR: Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?
Malar J 2012, 11:34. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Anthony MP, Burrows JN, Duparc S, Moehrle J, Wells TNC: The global pipeline of new medicines for the control and elimination of malaria.
Malar J 2012, 11:316. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text


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21 Jump Street Movie Quotes
'21 Jump Street' movie quotes include some of the funniest lines from this 2012 reboot of the classic 80s TV crime drama. The new '21 Jump Street' stars Jonah Hill and Channing Tatum as officers Schmidt and Jenko -- two guys who aren't exactly cop material. Not surprisingly, some of the best quotes from '21 Jump Street' are uttered by Hill and Tatum, though several other cast members get great, memorable lines as well. See a favorite quote from the '21 Jump Street' reboot here? Vote it up! And, if you don't see your favorite quote listed, add it.
In '21 Jump Street,' Hill and Tatum are two police officers who are fresh out of the academy. Neither of them show a whole lot of promise as cops and, after they botch their first big arrest, they're (quickly) reassigned. The pair pose as brothers, going undercover at a local high school to try and bust a drug ring. As the pair get closer to uncovering the truth, they're forced to confront some old issues from their teen years -- with hilarious results. '21 Jump Street' also stars Ice Cube, Brie Larson, Rob Riggle, Dave Franco (James Franco's younger brother), Ellie Kemper and Nick Offerman, among others. And yes, original '21 Jump Street' TV show cast member Holly Robinson Peete reprises her role as Officer Judy Hoffs!
If you're interested in great movie quotes from other films, check out some of these lists for the best lines from 'A Thousand Words,' 'Project X,' 'The Lorax,' 'Wanderlust,' 'The Sitter,' 'The Secret World of Arrietty,' 'Journey 2: The Mysterious Island' 'The Woman in Black,' 'Hugo,' 'The Muppets,' 'The Rum Diary,' 'War Horse,' 'Arthur Christmas,' 'Happy Feet 2,' 'Tower Heist,' 'Puss in Boots,' 'The Smurfs' movie and 'Jack and Jill.'
- Tip: Navigate with your { left and right } arrow keys1
Miranda Rights«»+ 87- 13
Deputy Chief Hardy: "You forgot to read him his Miranda rights. Do you even know the Miranda rights?"
Jenko: "It obviously goes something like... you have the right to remain... an attorney."
Deputy Chief Hardy: "Did you just say you have the right to be an attorney?"
Schmidt: "You do have the right to be an attorney, if you want to..."
If Deputy Chief Hardy looks familiar, he should: That's Nick Offerman, aka Ron Swanson from NBC's 'Parks and Recreation.' How could this movie NOT be hilarious with Offerman on board?l< << PREV 1 of 10 NEXT >>


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severe weather
Behind the Scenes: Alerting You During Severe Weather [VIDEO]
This week in our "Behind the Scenes" series on WJON, we help you stay safe during severe weather at the Benton County Emergency Management Center. It doesn't take long for the skies to turn scary and that's when Jim McDermott and the Benton County Emergency Management Center spring into action.
Severe Thunderstorm Risk Moves Toward Southern MN on Sunday
Dayton Cancels Visit to SW Minnesota Due to Storms
Tornadoes Touch Down in Minnesota, But No Damage
WJON News On-Demand – Thursday, 2/21/13 – Midday
Here's today's headlines on WJON:
Two Men arrested for alleged drug possession near Little Falls
St. Cloud Mayor Dave Kleis supports red-light cameras
Minnesota House to take up requirements for staffing of nurses
Southern Minnesota to get snowstorm
WJON News
On The Air. Online. On Charter Channel 20. On Demand.
Large Facilities Train Staff for Severe Weather
Minnesotans Reminded to Plan for Severe Weather
Public safety officials say Monday's confirmed tornado is a reminder for Minnesotans to get ready for severe weather. The state Homeland Security and Emergency Management division is urging Minnesotans to review their severe weather plans and to take steps to keep their families safe.


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Amazon.com: Customer Reviews: Samsung UN85S9 85-Inch 4K Ultra HD 120Hz 3D Smart LED TV
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Houston Arrival Shuttle Transfer: Airport to Hotel
- Houston Arrival Shuttle Transfer: Airport to Hotel
- Get to your hotel efficiently and effectively
- Shared ride door-to-door ground transportation
What You Can Expect
Transfer services are available 24 hours a day, 7 days a week.
Customer Reviews
April 2015
Probably I was just lucky, but I did not wait even 5 minutes - bus arrived very fast and took me directly to the hotel. There were two of us in the van. Driver was good. Very preasant and low cost solution to go from airport to hotel.
February 2015
The driver was awesome! Quick drive to the hotel - barely had to lift a finger.


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The Growing Story (Hardcover)
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From this simple beginning grows a story that celebrates those little changes that tell us we're growing up! This Ruth Krauss classic enchanted young readers when it was first published in 1947. Now it blooms again with lush illustrations by one of the world's best-loved illustrators: Helen Oxenbury.
About the Author
Ruth Krauss (1901-1993), a member of the experimental Writer's Laboratory at the Bank Street School in New York City in the 1940s, imaginatively used humor and invented words to create some of the very first books for children that highlighted a child's inner life. She collaborated with some of the greatest illustrators in children's literature, including Maurice Sendak and her husband, Crockett Johnson.
Marc Simont (1915- ) was born in Paris. When he was 19, Mr. Simont moved to America. His first illustrations for a children's book appeared in 1939. Since then, he has illustrated nearly a hundred books, working with authors as diverse as Margaret Wise Brown and James Thurber. He won a Caldecott Honor in 1950 for illustrating Ruth Krauss's "The Happy Day," and in in 1957 he was awarded the Caldecott Medal for his pictures in "A Tree is Nice," by Janice May Udry. Mr. Simont and his wife have one grown son, two dogs and a cat. They live in West Cornwall, Connecticut.
Helen Oxenbury is the renowned illustrator of many classic picture books, including "We're Going on a Bear Hunt" by Michael Rosen and "The Three Little Wolves and the Big Bad Pig" by Eugene Trivizas. Ms. Oxenbury lives with her husband, illustrator John Burningham, in North London.


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Originally written on NESN.com | Last updated 8/6/12
Carl Crawford celebrated his 31st birthday on Sunday and, perhaps coincidentally, also had one of his best games all season. Now, with the Red Sox playing well on Monday, NESN Nation's Dan Duquette is trying to figure out whose birthday it is this time around. Or maybe it has something to do with Yu Darvish celebrating the opposite of his birthday, whatever that is. Check out the video above for more. Join NESN Nation: In-game home page | Twitter | Facebook
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They feel bad, so they found you these other deals to make up for it.
Select Local Merchants
Main StreetRead MoreA great drink spot, Main Street is home to a nice selection of brews and cocktails in San Antonio's Eden district. Catch the game at Main Street, a local restaurant with TVs. Outdoor dining doesn't get much better than the beautiful patio at Main Street. Music lovers can enjoy live performances at Main Street as well. Your pet pup can accompany you to Main Street, which has a dog-friendly policy. Weekend diners may find themselves waiting for a table, as Friday and Saturday nights tend to draw a crowd. Main Street is located in a prime location surrounded by various parking options. Frugal foodies will especially love the prices at Main Street, with a meal typically hovering under the $15 mark.13477 Wetmore RoadSan Antonio, TX US


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Is there a limit on the amount of categories for an Objective-C Class? I am making a bunch to make my class less lengthy and was just wondering if there was a limit on the amount of them you could have. Thanks.
There is no limit. They are an effective way of keeping long codes clean. Make sure to name them appropriately to avoid duplicates.
No there is not such a limit. Just try to prefix your Categories to avoid duplicates.
As has already been answered, no, there is no such limit, at least not that anyone here is aware of. There might be some theoretical limit, but it's unlikely that you would encounter it.
I felt I should post an answer to better answer what you asked in the comments. You wanted to know about how best to go about having different implementations for iPhone and iPad for your methods, and there are a few different options:
If performance is critical, the last option would have the best performance, if you were calling it many many times. However the last option also requires digging into the Objective-C runtime. The first and second options both involve checking which device it is every single time a method is called. However, if performance isn't super important, the first option is easiest to set up. Also the first option would allow you to have some code in common between the two without duplicating it in separate methods, so it might be ideal if this is the case. Also many times it is nice to be able to look in one place to find all of the logic for handling a particular action, and would make things easiest if somebody else needed to maintain your code.


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Mumford and Sons
Rousing bluegrass with a heavy heart
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Mirror Lake Elementary School is a public school in Plantation Township, Florida. It has 514 students in grades PK and K-5. According to state standards, 54% of students at this school are considered proficient in math and/or reading.
1200 Nw 72nd Ave
Plantation, FL 33313
Plantation, FL 33313
(754) 322-7100


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Key Takeaways As IT becomes more pervasive in all aspects of higher education, IT's customers need a user-friendly way of learning about and requesting IT services. A…
- Hoisted by My Own Petard
July 16, 2014
This will be my final post in the "Got a Minute?" blog series: I am wrapping up my time as EDUCAUSE Presidential Fellow. I'll spare everyone (including me!) the long goodbye; it has been …
- IT Restructuring: Challenges and Opportunities
July 14, 2014
Key Takeaways Driven by factors ranging from decreased financial support to changes in technology , IT restructuring is on the rise in higher education. Restructuri…
- The CIO Pipeline, Part 3: Being Strategic about Plumbing
June 11, 2014
This is the final entry in a three-post series related to the CIO Pipeline Challenge. Part 1 raised the potential of a "fracturing" of the CIO role into component parts (strateg…
- Supporting Information Governance through Records and Information Management
April 8, 2014
The expanding scope of IT initiatives in higher education institutions now goes well beyond basic desktop and enterprise applications. IT is often asked to focus on efforts to establish…
- IT Governance, Risk, and Compliance in Higher Education
March 18, 2014
Key Findings Formal enterprise or IT risk management and compliance programs are the exception rather than the rule. More common are informal processes and procedures for dealing with r…
- Selecting a Learning Management System: Advice from an Academic Perspective
April 21, 2014
Although faculty and students are the primary learning management system users, administrators and IT experts often select the system. This article stresses the importance of involving all sta…
- 2013 CDS Executive Summary Report
February 18, 2014
The EDUCAUSE Core Data Service (CDS) provides higher education CIOs and senior IT leaders with the benchmarks they need to make strategic decisions about IT at their institutions. Each ye…
- A Model for Project Prioritization in Higher Education Information Technology
February 24, 2014
Key Takeaways Organizations that achieve higher maturity in IT project portfolio management consistently show both increased performance and tighter alignment between IT and …
- Getting Your Ducks in a Row: Governance, Risk, and Compliance
December 6, 2013
Diana G. Oblinger is President and CEO of EDUCAUSE. Information technology is critical to higher education. But unless aligned with the institution's goals and based on sound p…


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Tags » Loaner Equipment
CTLR equipment and long-term laptop loaners
Two new additions to the equipment pool that you shouldn't have to worry much about, but that you should probably KNOW about. 1. CTLR is purchasing equipment to give to faculty and students for long-term loans, usually a semester or … Continue reading
New Equipment: Lighting Kit
We have a new lighting kit which includes 18 parts inside the case. The parts are numbered one through 18, making it easy to count them. There is a lighting kit checklist form to the right of the lighting kit … Continue reading
Booked Equipment Shelf Moved Over to the Right
When you retrieve a piece of equipment in the cabinet, you will see that the spot for booked items are now on the right side for easier access. The conference phones are on the same shelf. The conference camera is … Continue reading
3-day equipment loans
Starting now, all camcorders, digital cameras, and tripods have been changed to a 3-day loan for all borrowers (from a 1-day loan, previously). That is all.
Reminder to Confirm Items are Checked In ~~
This is an important reminder to be sure that you look at the check-in computer screen to confirm that each item you check in, is marked as such in Millennium. Don't be fooled; the audio beep upon check-in does not … Continue reading


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We pride ourselves on the care, condition, and temperament of our Weimaraners.We work very hard with our Weimaraners and the results show:
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custom erp software
Fatal Flaws in ERP Software Create Opportunity for Niche Software in CPG Companies
ERP software may fail to meet critical business requirements. When companies find that their ERP doesn't meet all of their business requirements, they should
custom erp software
without moving into creating custom software. Conclusions The issue of ERP fatal flaws outlined here is characteristic of many that face CPG companies who are looking to apply software to industry and segment specific problems. General ERP and CRM software is designed to focus on general business practices within broad industries. Specialized ERP software, like Process ERP provides solutions for specific industries and even segments within those industries. Niche software can be tailored to a specific
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Engineer-to-Order (ETO ERP)
The simplified definition of enterprise resource planning (ERP) software is a set of applications that automate finance and human resources departments and help manufacturers handle jobs such as order processing and production scheduling. ERP began as a term used to describe a sophisticated and integrated software system used for manufacturing. In its simplest sense, ERP systems create interactive environments designed to help companies manage and analyze the business processes associated with manufacturing goods, such as inventory control, order taking, accounting, and much more. Although this basic definition still holds true for ERP systems, today its definition is expanding. Today's leading ERP systems group all traditional company management functions (finance, sales, manufacturing, and human resources). Many systems include, with varying degrees of acceptance and skill, solutions that were formerly considered peripheral such as product data management (PDM), warehouse management, manufacturing execution system (MES), and reporting. During the last few years the functional perimeter of ERP systems began an expansion into its adjacent markets, such as supply chain management (SCM), customer relationship management (CRM), business intelligence/data warehousing, and e-business, the focus of this knowledge base is mainly on the traditional ERP realms of finance, materials planning, and human resources. The foundation of any ERP implementation must be a proper exercise of aligning customers' IT technology with their business strategies, and subsequent software selection.
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5-step CRM Software Selection Guide: A Pragmatist's Guide to CRM Software Selections
Selecting a new enterprise customer relationship management (CRM) solution is an undertaking that requires careful planning and managed execution. And in fact, there are a number of common mistakes that organizations make. Failing to execute the selection process in an objective and structured fashion can be an expensive financial mistake—as well as a fatal hit to your professional reputation.
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ABAS Business Software-One Mid-market ERP Vendor to Watch For
ABAS Business Software has built a name for itself as a mid-market enterprise resource planning (ERP) vendor to contend with. In his latest article, TEC principal analyst P.J. Jakovljevic reviews the company's major ERP offering, describes how the mid-market ERP vendor the differentiated itself from the pack, and talks with Alan Salton to get the president's perspective on the company's products, challenges, and strategies.
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ERP for Services Software Comparison Report
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Enterprise Process Improvement (EPI) Software: Customer and Software Vendor Collaboration
Having just completed implementing your enterprise-wide software, you are about lean back, put your feet up on the desk, and enjoy the fruits of your labor. Not so fast! While you were completing your implementation project, a new release of the software may have already hit the street or, for sure, there is one in the pipeline. Now you are faced with the decision as to if and when to take on the new release. Maybe now is the time to look at how a new class of software tools, enterprise process improvement (EPI), can assist you in the upgrade decision.
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Software Evaluation and Software Selection
Organizations are surrounded by ambiguity when making their implementation decisions. Accurate and relevant criteria that are properly weighed against an enterprise's needs, what-if scenarios, and supporting graphics and reports are essential when making a software selection.
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IFS Applications
Developed using open, component-based technology, IFS Applications provide extended enterprise resource planning (ERP) functionality, including customer relationship management (CRM); supply chain management (SCM); product lifecycle management (PLM); corporate performance management (CPM); enterprise asset management (EAM); and maintenance, repair, and overhaul (MRO) capabilities. IFS Applications' service-oriented architecture (SOA) is designed to help companies collaborate with partners, suppliers, and customers. IFS Applications are a comprehensive business system for midsize and large organizations. In addition to the processes that are supported by all business systems, such as finances, inventories, traditional manufacturing, and customer management, IFS Applications support the entire lifecycle of products from construction to maintenance and aftermarket services.
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Future Tech: Where Will ERP Be in Two Years?
Many ERP systems are deeply entrenched in organizations, and their core technologies are mature. And yet ERP is in a state of flux. The ERP system of the future promises to be simpler, more accessible, and easier to use, shaped by trends that only recently began taking hold. Download this concise executive brief to get an expert's take on what's next for ERP, in clear, easy-to-read language.
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Software Solutions
Trigent helps clients in industries such as commercial software, manufacturing, marketing and media. Its solution frameworks and development automation tools aid rapid time-to-deployment for software systems. The company's CMM-certified global development centers offer flexibility clients to address clients' varying requirements for software development, maintenance, and support services. Its software support includes knowledge support systems, parts management systems, and product configuration. Trigent has created and maintained applications for clients such as International Truck and Engine Corp. (Navistar), Classified Ventures, Information Resources, Inc. (IRI), and McCabe and Associates.
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Entry Software Corporation
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Everest Software Inc.
Founded in 1994, Everest Software is a privately-held, multinational software company headquartered in Dulles, Virginia (US). Everest Software has nearly 300 employees. The company has developed Everest, a business management solution for small and mid-size businesses in the wholesale, distribution, retail, and e-commerce industries. Over 3,000 small business in 49 countries use Everest, which was the winner of the 2004 SIIA Codie Award for Best Business Software Product. In 2009, Everest was acquired by Versata Enterprises. Versata revitalizes best-of-breed companies for the sake of customer success, often extending and evolving products for the long term. The current reach of Versata's companies is broad and the family grows each year through the acquisition of additional leading solution providers.
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Gaming Deals: $370 PS4 + Batman: Arkham Knight, $40 Borderlands Collection
$50 Elder Scrolls Online, $50 Batman: Arkham Knight, $15 Persona 4: Golden, $20 Kingdom Hearts: Dream Drop Distance, and more.
$50 Elder Scrolls Online, $50 Batman: Arkham Knight, $15 Persona 4: Golden, $20 Kingdom Hearts: Dream Drop Distance, and more.
Details on new screenshot features, journals, and posting restrictions have been released.
The platformer will be able to sit on your shelf later this year.
The online retailer's branch in Mexico started off with the sale of an amiibo.
Club Nintendo shuts down tonight.
Tower defence mode coming July 1.
Mario Spikers' combat meant it was not given the go ahead for development.
It's adorable.
$30 Xenoblade Chronicles 3D, $10 gift card with the new BlazBlue, Steam gift cards with Logitech mice and keyboards, and more.
Nintendo legend is pulling back from hardware development to focus on games.
Platform holder doesn't intend to abandon 3DS and Wii U owners for NX; will still release games for them.
Satoru Iwata says it wants to maintain value of products, new membership service will give you more.
Excellent Xbox One and PS4 bundles continue, $41-$42 Mortal Kombat X, $40 Final Fantasy X/X-2 Remaster, and much more.
Splatoon's arsenal grows even further.
$41-$42 Mortal Kombat X, $8 Watch Dogs PC, $40 PlayStation TV, $56 mechanical keyboard, and much more.
In a new interview, Miyamoto describes how he came up with Mario and why the Wii U is struggling.
Use your keyboard!
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WestLake Financial - Poor customer service
- Jun 29 2015-06-29 22:17:49
WestLake Financial
Westlake Financial Services, Inc. is an American privately held company. The company is a near-prime to subprime lender. Westlake Financial Services is headquartered in Southern California. Westlake Financial Services specializes in the originating, acquisition and processing of auto retail installment contracts. The company operates through a network of new and pre-owned auto dealerships located all over the United States. Westlake Financial Services is a financial division of Hankey Automotive Group. One of the most popular products of Westlake Financial Services is Westlake Financial Buy Program. Westlake Financial Services is one of the fastest growing companies in the auto financing industry.4751 WILSHIRE BLVD Los Angeles CA 90010-3827
- Auto Financing
- Sacramento, California
- Staff
- 20
Rude annoying employees. Try to punk you and make you feel worthless. No positive feedback or energy makes you want to jump off the Golden Gate Bridge. Some employees try to act as if they own the company it's annoying and mean. I lost my job and was talked to like I was being questioned by a freaking judge. I always try to make small payments to try and get caught up with my loan although it's... Read more ›Was this review helpful? 0 0 by anonymous


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Our Kentucky Chat Line site is the place to be where people in Kentucky are joining up us as they look to discover new people to chat with as soon as possible. Chatting to and meeting people has never been this easy to do and if you are looking for something to do online, our site is ideal for you! Join up today and you can may well be able to make new friends with our Kentucky Chat Line site today! Searching out singles to chat with is no longer going to be an issue when you join Kentucky Chat Line , so make sure that you our free membership and do not delay!
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Web Exclusive
Shawl Collar Faux Wrap Maxi Dress
Item# AS-000771_6644
$59.50 $16.98
This faux maxi is the real deal! The bright red and ivory print is set off with a side sash, in the tradition of the perfect wrap dress. We love this look for church, brunch, or bring a little color to the office! Imported.
- Machine washable. 100% Polyester.
- Web exclusive items must be returned to our online store.
Please Select a Size and Color
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Is it possible to perform request to
https using
http-request phing task?
If no - what workaround could you propose?
Is it possible to perform request to
If no - what workaround could you propose?
Yes, you are not limited to HTTP only - HTTPS works fine.
Examples are shown in the phing documentation:
Alternatively, you can use the curl adapter:
It seems that by default you won't be able to connect using https. This is because the Phing http task uses the PEAR HTTP_Request2 libraries to make the connection. That in turn uses either PHP curl or sockets to make the connection. When connecting to https it needs to verify the CA certificate. That can be switched off so any certificate is supported but the Phing task doesn't support passing the option over to HTTP_Request2.
So if you otherwise like the Phing http task I suggest you either copy and modify the task or write your own that extends the original one so it supports the
Here are links where you find more info:


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Prepare to go beyond: 'Star Trek 3' director reveals title and first photo
Justin Lin is preparing to boldly go where... several men have gone before.
Star Trek is an American science fiction entertainment series and media franchise. The Star Trek fictional universe created by Gene Roddenberry is the setting of six television series including the original 1966 Star Trek, in addition to ten feature films (with an eleventh in post-production), dozens of computer and video games, hundreds of novels and fan stories, several fan-created video productions, as well as a themed attraction in Las Vegas. The original TV series alone is one of the biggest cult phenomena of modern times and has spawned many pop culture references.
Justin Lin is preparing to boldly go where... several men have gone before.
If there are two things all dads universally love, it's dance music and the 'Star Trek' franchise.
Adam Nimoy is unique. He's the only person who can claim to be both the first Trekkie and the son of Spock, the Star Trek Enterprise's science officer. Not that that dual existence was always easy. "My relationship with him, having Spock in the house...
The famous ship of Captains Kirk and Picard has been boldly going for much longer than you think.
There's a building in China that looks almost exactly like the USS Enterprise from 'Star Trek.'
"While conceptual research into novel propulsion methods has created headlines, this is a small effort that has not yet shown any tangible results," NASA officials said.
Grace Lee Whitney, who played Yeoman Janice Rand in the original 'Star Trek' TV series and several of the movies, died at her home in California. She was 85.
Let Tim Russ tell you tales of magical space druids and death balls.
The most epic 'Star Trek' selfie ever.
Trek characters with Green Lantern Corps' Power Rings? Yes, that's going to happen.
Leonard Nimoy learned how to live long and prosper long before he became Spock from his rabbi.
Now that Leonard Nimoy is no longer with us, it's worth remembering the moments that made Spock the outstanding character he is.
The world has lost one of science fiction's greatest treasures.
No one will ever give a Vulcan salute quite like he did.
Aside from his role as the iconic Spock, Nimoy also appeared in many other movies and TV shows. Here are some of his most memorable roles.
Before Nimoy played the iconic role of Spock on 'Star Trek,' he was already an advocate for the preservation of outer space, as well as life on Earth.
Leonard Nimoy is no longer with us, but through Spock-inspired earrings and cutting boards, he will live in our hearts (and homes) forever.
Goodbye to Leonard Nimoy, who died Friday at age 83. You have been, and always shall be, our friend. The actor, photographer and author inspired millions -- not only with his role as Mr. Spock in the ultimate sci-fi series Star Trek, but also with hi...
Live long and prosper.
"Of all the souls I have encountered in my travels, his was the most human."
Find out what it is that touches you most deeply. Pursue it, learn about it, explore it, expand on it. Live with it and nurture it.Leonard Nimoy in a 2014 interview with MITLeonard Nimoy, the man who made Mr. Spock famous, died on Friday at age 83.Ni...
LOS ANGELES -- Leonard Nimoy was hospitalized late last week after experiencing severe chest pains, following multiple trips to the hospital for the Star Trek star in the past months, TMZ reported Monday. It wasn't clear whether Nimoy was still being...
Set phasers for "huh."
From Jean-Luc Picard to William Riker: here's story about beating cancer.
William Shatner, Patrick Stewart and the cast of Star Trek: The Next Generation took the stage for a rollicking look back at the now-classic TV series.
The original Captain James T. Kirk could finally have a very small role in the new film series.
Being a starship captain is so much more than giving commands and flying through space. You have to have a big, caring heart -- just like Captain Picard.
A Spock-themed porn would have been highly illogical.
Stardate 2016: It's the near future, and one of America's most beloved science fiction icons is celebrating a major milestone. Phasers on stun: Star Trek is turning 50. Back here in 2014, that event seems almost light years away, but it's never too e...
This universal remote is shaped like a Star Trek phaser, complete with authentic sounds from the show.
Former CEO of the networking site FriendFinder Marc Bell is listing his gorgeous, Mediterranean-style Florida home to the tune of $35 million. His incredible mansion includes eight bedrooms, 16 bathrooms and a couple of 'Star Trek' themed entertainment rooms -- including a detailed recreation of the Starship Enterprise.


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Security Officers Injured Protecting Turkish-Bulgarian Leader's Assaulter
2 officers from Bulgaria's National Security Service have been injured while trying to cover and drag away the person who made an unsuccessful assassination attempt against Movement for Rights and Freedoms leader Ahmed Dogan.
This was revealed at a press event later Saturday evening by Security Service head Gen. Todor Kodzheykov, who said that one of the officers had possibly suffered a broken arm.
Kodzheykov stated that the two officers attempted to protect the assaulter from the delegates at the MRF congress, who had proceeded to mercilessly beat and kick him, after he made two ineffective attempts to shoot at Dogan during the event.
The Security Service head said that the agency was not formally responsible for organizing the security of the congress, its official duty being only the personal security of Ahmed Dogan.
Kodzheykov added that the Service is carrying out an analysis of exactly how the incident occured and whether there were any breaches in the work of officers at the location.
The National Security Service is a Bulgarian state agency devoted to bodyguarding senior Bulgarian statesmen and politicians who are believed to be under threat for their personal security.
Dogan, who has been chairing the Movement since its founding as a party in 1990, has been placed under the Security Service's protection.
- » Bulgarian Entrepreneur Detained over Tax Fraud Probe in Italy
- » Police in Brussels Intercept Ecstasy Import Scheme from Bulgaria
- » Ex Bulgarian Public Official Gets 2 Years in Jail for Leaking Wiretapping Data
- » Bulgarian Court Increases Prison Sentence of Pazardzhik Imam over Preaching Radical Islam
- » Bulgaria Police Detain 35 Migrants in Downtown Sofia
- » Bulgaria Seizes 5.6 Kg Heroin at Border with Turkey
"2 officers from Bulgaria's National Security Service have been injured while trying to cover and drag away the person who made an unsuccessful....."------one simple question: will those bastards-who
injured the officers on duty- be found and taken to the Court? (and I don't ask why these officers didn't start shooting in reply to those turks' attack on them.....in, say, USA such attackers on the policemen
would get a bullet immediately. Any doubt?)
What a load of crap.
The young boy should never have been able to point a gun so close at Dogan's head.
Anyway, I'm not surprised.
Cartoon and chalga bozoes all way round, when it comes to Bulgaria's NS operatives.
Probably fat boys with no brains, only fit to smash cortege cars.
Just my two stotinki


text:
Weiss holds a Ph.D. and master's degree in mechanical engineering from University of California-Berkeley, and a bachelor's degree in mechanical engineering from Cornell University. She previously taught at University of California-Berkeley and Cornell University. She has industry experience at Sandia National Laboratories.
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