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Fatty acid regulation of hepatic lipid metabolism
Donald B. Jump
Department of Nutrition and Exercise Sciences, The Linus Pauling Institute, Oregon State
University, Corvallis, Oregon, USA
Purpose of review—To discuss transcriptional mechanisms regulating hepatic lipid
Recent findings—Humans who are obese or have diabetes (NIDDM) or metabolic syndrome
(MetS) have low blood and tissue levels of C20–22 polyunsaturated fatty acids (PUFAs). Although
the impact of low C20–22 PUFAs on disease progression in humans is not fully understood, studies
with mice have provided clues suggesting that impaired PUFA metabolism may contribute to the
severity of risk factors associated with NIDDM and MetS. High fat diets promote hyperglycemia,
insulin resistance and fatty liver in C57BL/6J mice, an effect that correlates with suppressed
expression of enzymes involved in PUFA synthesis and decreased hepatic C20–22 PUFA content.
A/J mice, in contrast, are resistant to diet-induced obesity and diabetes; these mice have elevated
expression of hepatic enzymes involved in PUFA synthesis and C20–22 PUFA content. Moreover,
loss-of-function and gain-of-function studies have identified fatty acid elongase (Elovl5), a key
enzyme involved in PUFA synthesis, as a regulator of hepatic lipid and carbohydrate metabolism.
Elovl5 activity regulates hepatic C20–22 PUFA content, signaling pathways (Akt and PP2A) and
transcription factors (SREBP-1, PPARα, FoxO1 and PGC1α) that control fatty acid synthesis and
Summary—These studies may help define novel strategies to control fatty liver and
hyperglycemia associated with NIDDM and MetS.
fatty acid elongation; fatty acid synthesis and oxidation; fatty liver; FoxO1; gluconeogenesis;
VLDL metabolism
Dietary fat is an essential component in the human diet, but too much fat or an imbalance of
the type of fat can have negative effects on health and well-being [1••]. Chronic
consumption of excessive calories coupled with physical inactivity promotes obesity,
diabetes and metabolic syndrome [2••]. Obesity is associated with excessive ectopic
deposition of fat in tissues, such as heart, β-cell, liver and adipose, leading to lipotoxicity
and inflammation [3]. The accumulation of lipid in liver, that is, hepatosteatosis, leads to
nonalcoholic fatty liver disease, a growing health problem in the obese population and more
severe liver diseases such as nonalcoholic steatohepatitis, fibrosis, cirrhosis and cancer [4•].
Although excessive saturated fat (SFA) consumption promotes lipid storage and
© 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Correspondence to Donald B. Jump, PhD, 107A Milam Hall, Department of Nutrition and Exercise Sciences, Oregon State
University, Corvallis, OR 97331, USA, Tel: +1 541 737 4007; firstname.lastname@example.com.
NIH Public Access
Author Manuscript
Curr Opin Clin Nutr Metab Care. Author manuscript; available in PMC 2012 May 21.
Published in final edited form as:
Curr Opin Clin Nutr Metab Care. 2011 March ; 14(2): 115–120. doi:10.1097/MCO.0b013e328342991c.
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inflammation, dietary polyunsaturated fatty acids (PUFAs) play a protective role by
controlling synthesis and oxidation of SFA and monounsaturated fatty acid (MUFA), lower
hepatic fat content [5] and improve blood lipid profiles associated with risk of
cardiovascular disease [1••,6]. The goal of this article is to highlight recent studies
implicating fatty acid synthesis as a target for controlling the severity of risk factors
associated with diabetes (NIDDM) and metabolic syndrome (MetS).
Dietary fat regulates de-novo lipogenesis and monounsaturated fatty acid
Expression of the enzymes involved in de novo lipogenesis (DNL) (ACC1, FASN) and
MUFA synthesis (SCD1 and Elovl6) synthesis are coordinately controlled during fasting
and refeeding, and by insulin, dietary carbohydrate and dietary fat (Fig. 1) [7,8]. This
coordinate regulation is due, at least in part, to the hormonal and nutrient control of key
transcription factors regulating the expression of these enzymes. These transcription factors
include SREBP-1 and the ChREBP/MLX, LXR/RXR and PPARα/RXR heterodimers
(Table 1) [5]. Insulin induces SREBP-1 nuclear abundance through several mechanisms,
including increased transcription of the SREBP-1c gene, stabilization of SREBP-1 mRNA
and protection of nuclear (mature) SREBP-1 from 26S proteasomal degradation. Feeding
mice high fat diets containing predominately saturated fat for a short duration (24–28 h)
induces SREBP-1 nuclear abundance and its co-activation by PGC1β. Elevated nuclear
content of SREBP-1 induces DNL, MUFA and triglyceride synthesis and storage [2••].
Long-term feeding (≥ 3 months) of high fat (lard) diets, however, has the opposite effect on
SREBP-1 nuclear abundance and its target genes [8,9•]. This differential response can be
linked to hepatic insulin resistance and elevated blood leptin and represents an adaption to
the high fat diet [10]. Leptin suppresses SREBP-1 nuclear abundance and the expression of
SREBP-1 target genes. Leptin also induces the phosphorylation of AMP-kinase (AMPK),
which in turn phosphorylates acetyl CoA carboxylase (ACC) and lowers hepatic malonyl
CoA (Table 2) [2••]. Malonyl CoA is a substrate for DNL and fatty acid elongation as well
as an inhibitor of carnitine palmitoyl transferase-1 and β-oxidation [11].
High carbohydrate–low fat diets induce DNL and MUFA synthesis but diets supplemented
with PUFAs (ω3 or ω6 PUFAs) suppress SREBP-1 nuclear abundance and the expression of
genes involved in DNL and MUFA synthesis. Of the PUFAs examined, docosahexaneoic
acid (C22 : 6, ω3, DHA) is amongst the most robust suppressors of nuclear SREBP-1; DHA
counters many of the effects of insulin on SREBP-1 but does not induce insulin resistance.
This is achieved through effects on SREBP-1c gene transcription, SREBP-1 mRNA
turnover and a 26S proteasome-dependent and Erk-dependent mechanism that accelerate the
degradation of the mature form of SREBP-1 [5].
High carbohydrate–low fat diets also induce the accumulation of carbohydrate response
element binding protein (ChREBP) in the nucleus. ChREBP along with its heterodimer
partner max-like factor-X (MLX) control the expression of multiple genes (Glut2, L-PK,
ACC, FASN, SCD1 and Elovl6) involved in DNL and MUFA synthesis [12]. ChREBP
binding to DNA requires MLX as a heterodimer partner. Dietary PUFAs suppress the
nuclear content of both ChREBP and MLX nuclear abundance leading to a decline in
expression of ChREBP/MLX target genes [5].
The LXR/RXR heterodimer is a major regulator of lipogenic gene expression through direct
interaction with the promoters of these genes as well as inducing SREBP-1c gene
transcription. Activation of LXR by high dietary cholesterol, oxysterols or other agonists
elevates nuclear content of SREBP-1 and increases DNL and MUFA synthesis leading to
hyperlipidemia [13]. Some investigators have reported effects of fatty acids on LXR
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function [14], whereas others have found little effect of dietary PUFAs on LXR target genes
(ABCA1, ABCG5, ABCG8 and CYP7A) in vivo [5].
PPARα, PPARβ/δ, PPARγ1 and PPARγ2 are fatty acid-activated nuclear receptors that
respond to changes in intracellular fatty acid content [15]. In primary hepatocytes, however,
the response of PPARα to various fatty acids is not uniform. Eicosapentaenoic acid (C20 : 5,
ω3, EPA) is a robust activator of PPARα, whereas SFA, MUFA and other ω3 and ω6
PUFAs are weak regulators of PPARα [5]. PPARα is a major regulator of genes involved in
mitochondrial, peroxisomal and microsomal fatty acid oxidation as well as genes involved in
gluconeogenesis through its regulation of PGC1α and FGF21 [16•,17]. Moreover, PPARα
is a major drug target for treating severe hyperlipidemia. When compared to pharmaceutical
agonists, however, EPA is a weak activator of PPARα [5].
Elevated DNL and esterification of fatty acids into triglycerides contributes to the elevation
of plasma triglycerides seen in MetS. Elevated plasma triglycerides are an independent risk
factor for cardiovascular disease [18•–20•]. Hepatic production of VLDL is governed by
availability of substrate (TAG) and apolipoproteins required for VLDL assembly, such as
apoB. Dietary C20–22 ω3 PUFAs inhibit VLDL secretion by inhibiting DNL, enhancing
fatty acid oxidation, and promoting apoB degradation [21,22,23•,24].
Targeting fatty acid synthesis as a means to control risk factors associated
with NIDDM and metabolic syndrome
Ablation or overexpression of enzymes involved in DNL, that is, acetyl CoA carboxylase
(ACC1 and ACC2) [25•], fatty acid synthase (FASN) [26] or MUFA synthesis, that is,
stearoyl CoA desaturase-1 (SCD1) [27] or fatty acid elongase-6 (Elovl6) [28], significantly
affects the severity of diet-induced hyperglycemia, dyslipidemia and fatty liver. Ntambi's
group [27] was the first to report that mice lacking SCD1 are protected against diet-induced
and genetically induced obesity, fatty liver, hypertriglyceridemia and insulin resistance.
More recently, Brown et al. [29•] used an antisense oligonucleotide approach to suppress
SCD1 expression in LDLR−/−, ApoB100/100 mice, a model of hyperlipidemia and
atherosclerosis. Although suppression of SCD1 protects mice from diet-induced obesity,
insulin resistance and fatty liver, this treatment induced aortic atherosclerosis. In a
subsequent report, Rudel's group combined the SCD1 antisense oligonucleotide approach
with dietary ω3 PUFAs and prevented the symptoms of both MetS and atherosclerosis [30•].
Although these studies reveal the complexities associated with targeting a specific enzyme
to manage risk factors associated with metabolic disease, they also offer a remedy by
including dietary ω3 PUFA supplementation in the therapy regime.
Control of hepatic polyunsaturated fatty acid synthesis
Dietary PUFAs and in particular the C20–22 ω3 PUFAs are beneficial to human health and
well-being by controlling lipid metabolism, blood lipids and inflammation [1••,31–34].
Obese humans or patients with NIDDM or MetS, however, have low blood and tissue levels
of C20–22 PUFAs; an effect usually attributed to impaired PUFA synthesis [4•,35•–38•]. The
metabolic basis and physiological consequences of low circulating and tissue levels of
PUFAs in humans remain unclear. Studies on essential fatty acid deficiency and fatty acid
desaturase-2 (FADS2, Δ6 desaturase) null mice make clear the necessity for dietary PUFAs
and its conversion to ARA and DHA for the maintenance of multiple physiological
processes and well-being [39•,40•,41].
The conversion of dietary precursors, linoleic acid and α-linolenic acids, to ARA and DHA
requires fatty acid desaturases (FADS1, FADS2), fatty acid elongases (Elovl2 and Elovl5)
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and peroxisomal β-oxidation (Fig. 1) [5]. SREBP-1, PPARα, and HNF4α, but not ChREBP/
MLX or LXR/RXR control the expression levels of these enzymes (Table 1). When
compared with enzymes involved in DNL and MUFA synthesis, expression of these
enzymes is less responsive to changes in blood insulin, fasting or refeeding (Table 2) [7,8].
Recent studies in mice have provided some clues as to the significance of changes in PUFA
synthesis in the control of metabolic disease. In contrast to C57BL/6J mice, A/J mice are
resistant to high fat diet-induced obesity, atherosclerotic lesions and fatty liver. Microarray
analysis reveals elevated expression of enzymes involved in lipid metabolism, including
those involved in peroxisome biogenesis and β-oxidation, fatty acid elongation (Elovl5) and
desaturation (FADS1 and FADS2) [42•] in livers of A/J mice. Hall et al. [42•] linked the
increased hepatic expression of these enzymes to elevated ARA levels in
lysophosphatidylcholine and 2-arachidonylglycerol. These complex lipids are PPARα and
cannabinoid receptor agonists, respectively. Moreover, proinflammatory cytokines (IL-1β
and GSF) were lower in livers of A/J mice.
Livers of obese C57BL/6J mice fed high fat diets, however, have impaired PUFA synthesis
as reflected by a low ratio of C20 : 4, ω6 to C18 : 2, ω6 and suppressed expression and
activity of Elovl5. Interestingly, the expression of FADS1 or FADS2 was not affected by
high fat (lard) diets [8]. Global ablation of Elovl5 lowers hepatic ARA and promotes fatty
liver; an effect linked to the induction of nuclear SREBP-1 but not ChREBP [43]. In
contrast, induction of hepatic Elovl5 activity, using a recombinant adenovirus approach,
essentially abolished fatty liver in obese-diabetic mice [9•,44]. Although induction of
hepatic Elovl5 activity did not elevate hepatic C20 : 4, ω6 levels, di-homo-γ-linolenic acid
(C20 : 3, ω6) and adrenic acid (C22 : 4, ω6) were increased in livers of these mice [9•].
Hepatic steatosis is associated with low β-oxidation [4•] and low fasting blood levels of β-
hydroxybutyrate [9•]. Increasing hepatic Elovl5 activity in obese mice restored β-
hydroxybutyrate to normal levels suggesting that Elovl5 induced β-oxidation and
ketogenesis. Because several targets of PPARα action were suppressed in livers of obese
mice with elevated hepatic Elovl5 activity, Elovl5 may induce β-oxidation and ketogenesis
through mechanisms independent of PPARα. The outcome of these studies establishes that:
fatty acid elongases are regulated by diet; endogenous PUFA synthesis controls hepatic
triglyceride content; and a change in elongase activity alone is sufficient to impact PUFA
synthesis and hepatic triglyceride content. Similar studies using the FADS2 null mouse have
not been reported but it is anticipated that FADS1 and FADS2 play equally important roles
in controlling hepatic lipid metabolism and the onset of fatty liver and dyslipidemia.
Fatty acid control of hepatic glucose metabolism
Mice fed high fat (saturated) diets have fasting hyperglycemia due to increased hepatic
glucose production and insulin resistance [45,46]. Hepatic glucose production during fasting
is due to the induction of glycogenolysis and gluconeogenesis as well as the availability of
gluconeogenic substrates [47•,48•]. Expression of enzymes involved in gluconeogenesis,
that is, phosphoenolpyruvate carboxykinase (Pck1), pyruvate carboxylase (Pcx) and
glucose-6 phosphatase catalytic unit (G6Pc), is controlled by several transcription factors
(FoxO1, CREB, HNF4α, c/EBP and PPARα) and regulatory proteins (PGC1α, CBP,
CRTC2, TRB3 and SIRT1) [46,49•,50,51]. CREB, CRTC2, FoxO1 and PGC1α have been
identified as major regulators of Pck1 and G6Pc expression in fasting induced
gluconeogenesis [46,52,53].
C57BL/6J mice fed high-fat diets develop fasting hyperglycemia, hyperinsulinemia and
glucose intolerance [8,9•,45]. Hepatic nuclei of these mice have elevated levels of FoxO1,
CRTC2 and PGC1α which induces expression of Pck1 and G6Pc. Livers of these obese
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diabetic mice have a low ratio of C20 : 4, ω6 to C18 : 2, ω6 and low activity of Elovl5
reflecting problems with PUFA synthesis. Inducing hepatic Elovl5 activity elevated hepatic
C20–22 PUFAs and abrogates fasting hyperglycemia, hyperinsulinemia and glucose
intolerance in these obese mice [9•]. Elevated Elovl5 activity attenuated Pck1 and G6Pc
expression and suppressed nuclear content of FoxO1 and PGC1α but had no effect on the
nuclear content of CREB, CRTC2, PPARα or HNF4α.
Nuclear levels of FoxO1 are regulated by controlling its phosphorylation and acetylation
status [54•]. The serine–threonine kinase, Akt and the phosphatases, PP2A and MKP-3,
control the phosphorylation status of FoxO1 [55–57,58•]. Transcriptional co-activators with
histone acetyl transferase activity, for example CREB-binding protein (CBP) and protein
deacetylase activity, for example, sirtuins 1 (SIRT1), control the acetylation status of FoxO1
and PGC1α [54•,59]. The Elovl5-mediated decline in nuclear FoxO1 content was correlated
with increased FoxO1 phosphorylation; phospho-FoxO1 is excluded from nuclei and
degraded in the proteasome. Increased hepatic phospho-FoxO1 was correlated with elevated
phosphorylation of Akt and the catalytic unit of PP2A. Phospho-Akt is an active kinase,
whereas phosphorylation of PP2A catalytic unit inactivates PP2A phosphatase activity.
Moreover, elevated Elovl5 activity suppressed hepatic levels of the Akt inhibitor, TRB3, but
did not stimulate the phosphorylation of IRS2 or PDK1/2. The outcome of these studies
indicates that elevation of hepatic Elovl5 activity maintains the phosphorylated form of
FoxO1 during fasting, an event that lowers nuclear FoxO1 and suppresses expression of
enzymes involved in gluconeogenesis. Similar studies investigating the effects of Elovl5 on
the acetylation status of FoxO1 and PGC1α have not been reported. The outcome of these
studies identified a novel link between hepatic carbohydrate metabolism and PUFA
metabolism not seen with dietary C20–22 PUFAs.
Studies with genetically modified mice have established that enzymes involved in DNL and
MUFA synthesis play an important role in controlling metabolism, gene expression and the
onset and progression of diabetes and obesity. Recent studies with enzymes involved in
PUFA synthesis indicate that these enzymes are equally important regulators of plasma and
tissue fatty acid composition, signaling pathways controlling DNL, MUFA synthesis and
gluconeogenesis. Although dietary PUFAs have well-established benefits to human health
[1••], the studies discussed above indicate that controlling PUFA synthesis may provide
additional health benefits not seen with dietary PUFAs alone.
This project was supported by the National Institutes of Health Grant DK43220 and the United States Department
of Agriculture, National Institute for Food and Agriculture Grant 2009-65200-05846. The author thanks Drs Philip
C. Calder, Richard Deckelbaum, William S. Harris and Penny Kris-Etherton for their helpful comments and
enthusiastic support.
References and recommended reading
Papers of particular interest, published within the annual period of review, have been
highlighted as:
• of special interest
•• of outstanding interest
Additional references related to this topic can also be found in the Current World Literature
section in this issue (pp. 213–214).
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text:
Good News for Strava Athletes & Fitbit Lovers
05/12/2015 by | 1 Comment
Strava and Fitbit are excited to be partnering to make it even easier for our members to track all day activity, track exercise and maximize workouts. You can now connect your Fitbit account with Strava, which means your workouts logged in Fitbit will automatically sync to Strava, and your Strava workouts will sync to Fitbit!
You can use Strava for the times when you're pushing hard cycling or running, and Fitbit for all-day health and fitness tracking and stats, for insights into your overall health.
If you're a Fitbit Surge user, heart rate and GPS-based exercise data, including routes, distance, elevation and pace, will sync to Strava – whether you track a run or use our new biking feature! MobileRun users with any Fitbit device will also be able to view their GPS data in Strava.
You can find more ways to gauge progress and achieve your goals by tracking your workouts with Fitbit and using Strava's performance analytics tools, while competing with a global community of athletes including professionals, friends, teammates and clubs for added daily motivation and inspiration.
Get started today by connecting your accounts, then get moving to view your exercise in either app! The Strava app is available on Apple iTunes and Google Play.

subset: commoncrawl


text:
Dozens of Bristol schools to close for strike action
Posted: November 26, 2011|
DOZENS of schools will close and thousands of NHS staff will walk out when public sector workers strike over pensions.
More than 150 primary and secondary schools in the Bristol area have confirmed they will shut their doors as teachers join the industrial action this coming Wednesday.A list of schools involved can be found at the bpottom of this article.
Employees at hospitals in Bristol and Weston-super-Mare will take part in the mass walk-out, along with ambulance service staff, but NHS bosses insist emergency cover will be maintained.
Picket lines will be formed across the city and Park Street will be closed to traffic as protesters march from College Green to Castle Park.
Related content
Chiefs at Bristol Airport are hoping to minimise disruption caused by immigration officers backing the one-day strike.
Automated passport gates will be open all day in a bid to prevent queues building up as passengers arrive on flights from overseas.
Councils say libraries and other services could be affected but promise care and social services will be protected.
Staff at courts, job centres, the probation service, universities, colleges driving test centres and TV Licensing will also down tools.
In Bristol, almost 80 schools, children's centres and pupil referral units will close. North Somerset will see more than 50 closures while a further 58 will shut in South Gloucestershire.
This is likely to have a knock-on effect as parents unable to get childcare will be taking the day off to look after their children.
More than two million public sector workers are set to strike over proposed changes to their pensions.
Unions say proposals which require their members to work longer before retirement and contribute more are unfair, but the government says change is needed to keep down the cost to the taxpayer, because people are living longer.
Father-of-three Alistair Lindsay, from Clevedon, supports the strike. He said: "A good education is the most important thing our children can have and our teachers, tutors and school staff are all a part of providing that vital start in life.
"Teaching is not a job – it is a vocation, and many dedicate their lives to the education of others. It is a shame to see them cast aside and forgotten when they decide to retire."
Unison said about 900 members at Great Western Ambulance Service will strike, with emergency call handlers and staff responding to 999 calls from picket lines at stations. Association of Professional Ambulance Personnel members voted not to join their colleagues in the strike.
Bristol paramedic and Unison representative Chris Hewett said: "Non-essential staff members will be taking strike action for the full 24 hours. Essential staff, including emergency ambulance staff and control rooms, will be providing life and limb cover.
"Patients can be reassured that if they have emergency medical problems on November 30, they need to dial 999 and we will come."
At North Bristol NHS Trust, which runs Frenchay and Southmead hospitals, about 25 per cent of staff – up to 2,300 employees – could strike.
Accident and emergency and maternity services will not be affected but restaurants will be closed and disruption is expected to non-urgent outpatient appointments.
The trust's director of organisation, people and performance, Harry Hayer, said its bank staff service – which covers shifts – had been asked to extend its opening hours.
He said: "We have written to all our staff asking for volunteers to help out if and when we might need them.
"One of our concerns is staff going off sick to care for children. We have given notice and asked all staff to make contingency arrangements."
At the city centre hospitals emergency services will run as normal and appointments have been planned around the proposed strike. Patients are being notified of any changes.
James Rimmer, chief operating officer for University Hospitals Bristol NHS Foundation Trust, which runs the Bristol Royal Infirmary, said: "Our good working relationship with staff and union representatives means that we have shared information, know which services will be affected, and have planned clinics and elective procedures accordingly."
Unison regional organiser Judy Wilson said emergency cover had been negotiated with councils so staff in residential homes and maintenance workers could carry out emergency duties such as fixing heating in old people's homes.
She said: "When we take strike action we do not put people at adverse risk.
"Our members have had two years of pay freezes, the cost of living is going up and their pension is very important to them and what the Government is asking members to do is pay more, work longer and get less when they retire."
Rowena Haywood, spokeswoman for the GMB union, said up to 400 of its members would join the strike, including cleaners, gardeners, school caretakers and youth workers.
She said: "Our members are fearful of what will happen when they reach retirement age."
Bristol Federation of Small Business chairman Guy Kingston was critical of the strikers.
He said: "They risk being branded selfish and greedy at a time when many small business owners are not even making the national minimum wage."
Bristol Nursery Schools & Early Years EstablishmentsHartcliffe Children's CentreIlminster Avenue Specialist Nursery School & Children's CentreKnowle West Children's CentreRosemary Early Years Centre (except family support including primary age)St Philip's Marsh Nursery SchoolSt Werburgh's Park Nursery School & Children's CentrePrimary Schools (including Infant and Junior Schools)Ashley Down Infant SchoolAshley Down Junior SchoolAshton Gate Primary SchoolAshton Vale Primary SchoolBegbrook Primary SchoolBlaise Primary & Nursery School Brentry Primary SchoolBridge Farm Primary School Broomhill Infant School & Children's CentreCheddar Grove Primary SchoolChrist Church C.E. V.C. Primary SchoolColston's Primary School Compass Point: South St. School & Children's Centre Easton C.E. Primary SchoolElmlea Infant School Fair Furlong Primary School (except for Years 5 and 6)Filton Avenue Infant SchoolFonthill Primary School Four Acres Primary School & Children's Centre (except for Ants (Y1 & R) Frogs (Y1) and Badgers (Y5). CC open)Gay Elms Primary School Glenfrome Primary School Greenfield Primary SchoolHenbury Court Primary SchoolHillcrest Primary School Holymead Infant SchoolLuckwell Primary SchoolMay Park Primary School (except Years 5 and 6)Oldbury Court Primary SchoolOur Lady Of The Rosary Catholic Primary SchoolPerry Court Infant SchoolPerry Court Junior SchoolSchool Of Christ The KingSea Mills Primary School Sefton Park Infant School Sefton Park Junior School St Anne's Infant SchoolSt Anne's Junior School (one class open – contact school for details)St Anne's Park Primary SchoolSt Michael's on the Mount C.E. V.C Primary SchoolSt Peter's Church of England Primary SchoolSt Pius X Catholic V.A. Primary SchoolSummerhill Infant School except classes Hedgehogs (year 1) and Pines (year 2)Summerhill Junior School Victoria Park Primary SchoolWansdyke Primary SchoolWest Town Lane Primary School (school is open to 11 classes and closed to four – contact school)Whitehall Primary SchoolSecondary SchoolsBedminster Down Secondary SchoolBrislington Enterprise CollegeFairfield High SchoolMerchants' AcademyOasis Academy BrightstoweRedland Green School Redland Green School 16-19 CentreSt Bernadette Catholic Secondary SchoolSt Mary Redcliffe & Temple C.E. V.A. Secondary School The City AcademySpecial SchoolsBriarwood Special SchoolBristol Gateway SchoolClaremont SchoolElmfield School for Deaf ChildrenKingsweston Special School Knowle DGENew Fosseway Special School Notton House Special School Woodstock Special School Pupil Referral UnitsBristol Hospital Education Service Lansdown Park Secondary Specialist ProvisionSt. Matthias Park Pupil Referral Unit The Meriton – Young Parents Education & SupportNorth SomersetPrimary Schools closuresAshcombe, Weston-super-MareBanwell SchoolBecket, Weston-super-MareBirdwell School, Long AshtonBlagdon School (partial closure classes 1 and 2)Bournville School, Weston-super-MareBurrington SchoolCastle Batch School, Weston-super-MareChrist Church, Weston-super-Mare (partial closure all classes open except reception) Flax BourtonGolden Valley, Nailsea (partial closure Years affected Yr 1 & Yr 3 (1 class closed), Y4 (both classes closed), Y5 (1 class closed), Y6 (both classes closed)Grove Junior, NailseaHannah More Infant, NailseaHerons Moor, Weston-super-MareHigh Down Infant, Portishead (partial closure, nursery (Toucans), reception (Puffins), Y1 (Penguins, Flamingoes and Ducks), Y2 (Seagulls) all closedHillside First, Weston-super-MareHutton, Weston-super-Mare (partial closure reception, Yr 2&3 open, Yr 1, 4, 5&6 closedKingshill School, NailseaLocking, Weston-super-Mare, partial closure Classes 1C, 2F, 4/5S and 5/6CMary Elton, Clevedon (partial closure Yr 1 Beech and Cherry classes, Yr 2 Elm class, Yr 3 Holly class, Yr 4 Oak class and Yr 6 Sycamore classes closed)Mendip Green First, Weston-super-MareNorthleaze, Long Ashton (partial closure: reception in for lunch and pm; Yr 1&2 normal day; Yr 3 open from 12.20; Y4 in am, collect at 1.15; Yr 5, closed; Yr 6, openOldmixon, Weston-super-MareSt. Anne's, Weston-super-MareSt. John the Evangelist CE, ClevedonSt. Mark's, WorleSt. Peter's, Portishead (partial closure Yrs 1&6 are open, other years closed)Sandford SchoolTickenham School, ClevedonUphill, Weston-super-MareWalliscote, Weston-super-MareWest Leigh School, BackwellWindwhistle School, Weston-super-MareWinford SchoolWinscombe SchoolYatton Junior (partial closure: closed to Classes 1 Yr 3/4, 1 Yr 4, 1 Yr 5 and 2 Yr 6 )Yeo Moor Primary, ClevedonSecondary SchoolsBackwell SchoolBroadoak, Weston-super-MareChurchill SchoolGordano SchoolNailsea SchoolPriory, Weston-super-MareKatherine's, PillSpecial SchoolsBaytree, Weston-super-Mare (partial closure, check with school)Westhaven, Weston-super-MareEducation other than at schoolFairways, Uphill, Weston-super-MareThe Larch Centre, Weston-super-MareOakhill, NailseaSAIL @ Weston CollegeTuition Service NorthTuition Service SouthEOTAS Vocational CentreChildren's CentresClevedon (closed from 11.30)YattonSouth GloucestershirePrimary Schools (including Infant and Junior Schools)Almondsbury Church of England Primary School (partial closure)Baileys Court Primary SchoolBarrs Court Primary SchoolBeacon Rise Primary SchoolBowsland Green Primary School (partial closure)Bromley Heath Junior SchoolCadbury Heath Primary SchoolCallicroft Primary SchoolCharborough Road Primary SchoolCharfield Primary SchoolCherry Garden Primary SchoolChrist the King Catholic Primary School, ThornburyConiston Primary School (partial closure)Courtney Primary SchoolCrossways Infant SchoolElm Park Primary SchoolEmersons Green PrimaryFilton Hill Primary SchoolFrampton Cotterell Church of England Primary School (partial closure)Gillingstool Primary SchoolHambrook Primary School (partial closure)Hawkesbury Church of England Primary SchoolHoly Family Catholic Primary School, PatchwayManorbrook Primary SchoolThe Manor (Coalpit Heath) Church of England Primary School (partial closure)North Road Community Primary SchoolOldbury on Severn Church of England Primary SchoolOur Lady of Lourdes Catholic Primary School (partial closure)Pucklechurch Church of England Primary SchoolRangeworthy Church of England Primary SchoolRaysfield Infants' School (partial closure)Raysfield Junior SchoolThe Ridge Junior School (partial closure)St Andrew's Church of England Primary School, CromhallSt Chad's Patchway Church of England Primary SchoolSt Helen's Church of England Primary School, AlvestonSt Mary's Church of England CE VA Primary School, ThornburySt Mary's Catholic RC VA Primary School, Bradley Stoke (partial closure)St Michael's Church of England Primary School, Stoke GiffordSt Michael's Church of England Primary School, WinterbourneSt Paul's Catholic Primary School (partial closure)St Peter's Primary SchoolSt Stephen's Church of England Junior School, Soundwell (partial closure)Severn Beach Primary SchoolShield Road Primary SchoolTrinity Church of England Primary SchoolThe Tynings SchoolTyndale Primary SchoolWheatfield Primary SchoolWick Church of England Primary SchoolSpecial schoolsNew Siblands SchoolSecondary schoolsAbbeywood Community School (formerly Filton High)Bradley Stoke Community SchoolThe Castle School, ThornburyChipping Sodbury SchoolDownend School (partial closure)The Grange Community SchoolHanham High SchoolPatchway Community College (partial closure)Bath and North-East SomersetNursery Schools & Early Years EstablishmentsSt Keyna NurseryPrimary SchoolsSt Johns Primary SchoolCastle Primary School (partially open)Chandag Infant SchoolSt Keyna Primary SchoolSecondary schoolsWellsway School


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Req No. .. Location US-WA-Issaquah Category Architecture/Engineering Job Description: Sr. Software Development Engineer- Analytics Platform Issaquah, WA Job Overview As a Sr. Software Development Engineer for the Analytics platform, you will be a technical leader who5/27/2015 Issaquah, WA Save This Job
What: The Sales Engineer provides technical sales support as the product expert on the South West Sales Team. The SE is a highly technical sales professional who is responsible for working with their Regional Sales Managers and Inside Sales Executive to drive significant revenue5/27/2015 CA Save This Job
Identropy seeks a Senior Identity and Access Management Engineer in Austin, TX & other US locations as needed. Responsible for leading, designing, developing, and managing the technical components required for delivering on the IAM Architect's vision, including design and5/26/2015 New York, NY Save This Job
The Engineering Team at BetterDoctor is dedicated to creating world class consumer and provider facing products to help real people navigate the vast, wild and unruly healthcare space. We strive to live in the intersection between efficiency and ingenuity where every voice is5/18/2015 San Francisco, CA Save This Job
Software Engineer (Full Stack) ? Manageability Summary As a key member of the manageability team, you will be working on the end-to-end design and development of the next generation of PanActive Manager, the software that manages and monitors the various hardware and5/18/2015 Sunnyvale, CA Save This Job
Software Engineer ? File Systems This position is located in Pittsburgh, PA Summary: As a member of the Panasas File Systems engineering team, you will be working on the design and development of PanFS, an object based network attached storage system. Working with other5/18/2015 Pittsburgh, PA Save This Job
Location:TX - Austin Job Category:Research and Development Employment Duration:Full Time # of Openings:1 More and more companies with complex, outsourced networks of suppliers, logistics providers, and distributors lack much needed visibility, collaboration, and control over the5/13/2015 Austin, TX Save This Job
Oasys Water is seeking an experienced Process Engineer to join our rapidly expanding team in Boston, MA. This position will be responsible for working collaboratively with the technology development (R&D) team, the product engineering group, and engineering team to design and5/12/2015 Boston, MA Save This Job
Position Description: Are you interested in Big Data technologies? Do you have a strong technical background and a keen interest in topics such as Hadoop, highly scalable databases or distributed systems? Are you interested in leveraging your existing technical knowledge as well5/11/2015 San Jose, CA Save This Job
Location:Wallingford, CT Job Code:785 # of openings:1 Description Recently ranked by Healthcare Informatics as one of the Top 100 Healthcare IT companies, SourceMedical provides outpatient information solutions and services for ambulatory surgery centers, surgical hospitals,5/10/2015 Wallingford, CT Save This Job
OPPORTUNITY OVERVIEW We are looking for a seasoned engineer who can design highly complex scalable products, crank up quality code, and ensure customer experience as one of the main pillars of development. This role will require being a heavy influencer in the organization,5/9/2015 San Jose, CA Save This Job
Description DEPARTMENT OVERVIEW Giant Media, a division of Adknowledge, is the #1 Native Video Platform (confirmed by comScore) that distributes branded videos for innovative, creative and forward-thinking brands and agencies. This team delivers highly targeted views leveraging5/9/2015 Los Angeles, CA Save This Job
Description DEPARTMENT OVERVIEW Giant Media, a division of Adknowledge, is the #1 Native Video Platform (confirmed by comScore) that distributes branded videos for innovative, creative and forward-thinking brands and agencies. This team delivers highly targeted views leveraging5/9/2015 Kansas City, MO Save This Job
SAY Media, a global online publishing and technology company, is seeking for a Senior Front End Engineer, who will push the boundaries of JavaScript, HTML and CSS and will share the responsibility of designing, developing, improving, and maintaining Tempest, our award-winning5/6/2015 San Francisco, CA Save This Job
Title:Senior Software Engineer Department:Retention Location:Remote, US Type:FullTime Position #:192369 Description: PURPOSE AND SCOPE: Jenzabar?s Product Development team has an immediate opening for a Senior Software Engineer. This position reports to the Director of Web5/6/2015 Boston, MA Save This Job
Say Media, a global online publishing and technology company, is seeking a Senior Front End Engineer to push the boundaries of JavaScript, HTML and CSS. Role is responsible to design, develop, improve, and maintain the publishing platform of the future. Who we are: Say Media5/6/2015 Portland, OR Save This Job
Location:-Field Based Job Code:906 Description Ellie Mae (NYSE:ELLI) is a leading provider of enterprise on-demand solutions, including an online network, software and services for the residential mortgage industry. Ellie Mae is leading the mortgage industry into the future,5/5/2015 Pleasanton, CA Save This Job
Operations and Customer Success Los Angeles, CA, United States About Us At AppDynamics, our Application Intelligence Platform helps today's software-defined businesses proactively monitor, manage and optimize the most complex software environments. All in real time, and all in5/5/2015 Los Angeles, CA Save This Job
You are an experienced software quality assurance engineer looking for an opportunity to work with cutting-edge technology. You seek a company that cares about software quality assurance but also is willing to invest in its QA team. You do not want your skillset to get stale,5/5/2015 Broomfield, CO Save This Job
Site : Not Specified Location : Concord NC US 28027 Education : Bachelors Skill : Engineering -> Controls, Design, Electrical Category : Professional Job Description : Perform engineering duties as well as organize all activities required for the development and implementation of5/3/2015 Concord, NC Save This Job


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A push for more school sports funding amidst Australia's poor Olympic performance has been backed by a Northern Territory expert on physical education...Tuesday 7 August 2012
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- About 1000 students swapped books for footy boots as part of a special workshop with the Richmond Tigers yesterday. ...Tuesday 3 March 2015
- Joshua Pether is a man who is driven by his passion to dance - and not even a spinal condition or small-town discrimination could extinguish the fire. His particular focus is emerging new forms of movement that broaden our idea of ability and supposed limitations of dis-ability - as he so ...Saturday 21 February 2015
- Robert Hoge says there's a special club for ugly people. It doesnt have an official name, you cant flash a membership card to get discounts, and members dont pay a joining free. The membership is writ large across faces: bumps over coarse brows, in scars that look like a blind mans dot to dot. The ugly ...Tuesday 3 September 2013
- Two modern-day philosophers who are also runners meditate on the physical. For Mark Rowlands there are philosophical stages to a long run that take him from Spinoza to Descartes through Hume and Sartre. For Damon Young, its Nietzsche who gets him running. ...Thursday 26 December 2013
- "Water is kind of unpredictable sometimes, it flows one way but that's not always the way you want to go."...Friday 6 December 2013
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- Marine Closures Back to the Drawing Board
- Regional Weed Officer Tahnee Thompson outlines the Katherine Regional Weed Management Plan
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$3.99It was like any other spring day in the quiet, peaceful community of Lapeer Parish, Louisiana. But for Sheriff Vic Ransonet it was the beginning of a nightmare. People were disappearing without a trace. Animals were being eaten right down to the bone. Lush fertile fields of crops were being stripped bare. But the sheriff knew the evil that lurked in the barns, sheds, and homes of the sleepy parish
$3.99It was in the summer of 1958 that the horror surfaced in the town of Whitfield, erupting like a festering boil, spewing its corruption on everyone near it. Those who survived the terror remember it as the summer of The Digging—the time when the hot wind began to blow, when The Devil's creatures rose from the putrid bowels of the earth, when the inhabitants of Whitfield were touched by . . . The
$3.99Each night they emerged from the murky depths of the swamp to claim another victim—a lovely, innocent, fertile female who would be carried off in huge hairy arms and plunged into a nightmare world of terror. Her screams would echo in the darkness. Her face would contort in the throes of horror and pain. But once taken, each became a mother of an unholy child, a link in the chain of madness and
$3.99In the seventh book in his bestselling Preacher series, William W. Johnstone gives his millions of avid fans exactly the kind of gritty, action-packed Western novel they look for from this prolific and hugely popular writer."A Messiah Shall Lead Them...".In the Wyoming wild, Blackfoot warriors prepare for battle, their bloodlust stirred by a legendary prophet promising victory in a war that will
$4.79"I'm not looking for a fight, but damned if I'll run from one."--Ben RainesOur Land Is Not Your LandChilling rumors of a new Nazi movement reach the rebel camp of Ben Raines and his freedom fighters. Led by descendents of Hitler's Third Reich, Commanding General Jesus Mendoza Hoffman has assembled a massive army in the mountains of South America. Estimated at more than 200,000 strong, Hoffman and
$3.99Jake Silver was a teenage misfit, a misunderstood genius who'd been cruelly tormented by his own sadistic father and others in his little Louisiana hometown. Jake was the perfect disciple for Them.They'd come from another world; disembodied begins who understood Jake's need for revenge. . .They would offer Jake the power to finally take it. . .All they wanted in return was his help in bringing
$3.99The evil that triumphed during that long-ago summer in Whitfield is festering now in the unsuspecting town of Logandale. Only Sam and Nydia Balon, lone survivors of the ancient horror, know the signs—the putrid stench rising from the bowels of the earth, the unspeakable, inexplicable atrocities, the hideous, horrifying Beasts—that mark the foul presence of the Prince of Darkness. Only they have
$5.99From the national bestselling authors of Stand Your Ground comes an explosive story of citizens' rights, government wrongs, and freedom's last stand—deep in the heart of Texas…AMERICA UNDER FIREG.W. Brannock is proud to be a rancher, a West Texan, and a American. The land he owns has been in his family for generations. But when the IRS claims he owes a fortune in back taxes—and some stiffs from
$6.49The Greatest Western Writers Of The 21st CenturyA bold, sprawling epic of the American West, the Jensen family saga has captivated readers for nearly three decades. Now comes the untold story of Smoke Jensen's long-lost nephews, Ace and Chance, a pair of young-gun twins as reckless and wild as the frontier itself. . .Luck Of The DrawTheir father is Luke Jensen, supposedly killed in the Civil War.
$6.29The Greatest Western Writer Of The 21st CenturyHe is brave, tough as leather, and has left behind a trail of deadly enemies--outlaws he's hunted down or killed with the cold heart of a man used to violence. A feared bounty hunter and the scourge of bad men everywhere, Flintlock carries an ancient Hawken muzzle-loader, handed down to him from the mountain man who raised him. He stands as the
Luke Jensen, Bounty Hunter Bad Men DieTHE GREATEST WESTERN WRITERS OF THE 21ST CENTURYIn this brilliant series from national bestselling authors William W. Johnstone and J.A. Johnstone, Luke Jensen, reported killed during the Civil War, comes back with a vengeance to forge his own legend in a violent, lawless land.BAD MEN BEWAREWhat started as a routine hunt and grab—putting outlaw Thorp McCluskey on a train to Cheyenne and prison—has


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Photoshopped McCain Zombie Images
"If I do all the things people said I wasn't doing right, Cindy said she'd get me an ice cream cone"
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Braham clinched its 11th straight Great River boys basketball title with a 79-68 home win over Aitkin Feb. 11, extending the team's conference win streak to 65 games. John Larson scored 24 points and also led with 6 assists for the Bombers against the Gobblers. Zach Dahlman had 16 points and 4 reb...Read More
braham boys basketball
Cambridge-Isanti boys basketball recorded two wins in three nights, beginning with a 74-63 victory over Coon Rapids Feb. 1. The win was the 400th for Bluejacket head coach Mike McDonald. Kyle McDonald scored 24 points, and Nate Cox hit 5-of-9 three-pointers to finish with 21 points. Matt Swanson fin...Read More
BRAHAM BASKETBALL UPDATES: Braham boys basketball enjoyed a good battle with Melrose Jan. 25 on the Hallenbeck Hall court, leaving St. Cloud with a 73-70 non-conference win. Zach Dahlman had a great all-around game by hitting 10-of-11 from the field, including sinking 4-of-4 shots from the arc to ...Read More
BASKETBALL UPDATES: The Cambridge-Isanti basketball squads had a fun doubleheader of games at North Branch Jan. 16, with the Bluejackets taking both tight conference battles. The C-I boys broke a 22-22 halftime game with a strong second half for a 58-49 win over the Vikings. Nate Cox led the way...Read More
BASKETBALL UPDATES: Braham needed a push at the end to record a 52-50 Great River victory at Aitkin Jan. 13 in the make-up game from last week. Connor Tschumper's steal and feed to John Larson broke a 48-48 tie. After the Gobblers re-knotted the game, Larson scored his 21st point on a jumper wi...Read More
BASKETBALL UPDATES: Blaine opened up a late 10-point lead and held on to defeat visiting Cambridge-Isanti girls basketball 61-55 in a matchup of Section 7AAAA rivals on Saturday. Justine Larson hit five field goals and was 5-for-5 at the line to lead the Bluejackets with 15 points against the Beng...Read More
Braham boys basketball picked up valuable experience while going 2-1 to place 3rd at last weekend's St. Cloud Cathedral "Crusader Christmas Classic" tourney. "This tournament always makes us a better team with its level of competition. You get three games over three days, so it forces the bo...Read More
BASKETBALL UPDATES: Devin Malik scored four of his 10 points in overtime, and Matt Swanson scored three points in the extra minutes when Cambridge boys basketball rallied on visiting North Branch 79-74 Dec. 19. The win improved the Bluejackets' overall record to 6-1. The Vikings led 37-28 at the h...Read More


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U.S. Apartment Rent Growth Levels Further Accelerate in Q2
Going into 2015, most prognosticators expected apartment rent growth levels to ease. Halfway into the year, the opposite has occurred. Year-over-year growth in new leases hit a new high for the cycle in Q2 2014, boosted by rapid acceleration in late-recovery markets combined with continued strength elsewhere.


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$10 off $75 Home, Sports, School Supplies, Fashion, & Beauty - Back to School. Use promo code BACK2SCHOOL at checkout. Ends 7/8/2015.
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I love it, love it, love it! Not enough money to paint the train, but the bridge to nowhere seem to have loads of money. For a possible site of offices and a hotel. When? I guess in 2025.
What better time to pray? Our country is in the midst of the process of electing a president and Congress members for the next four years. Our servicemen and women are deployed in the very dangerous countries of Iraq and Afghanistan as well as other parts of the world. The economy of our country is teetering on collapse. Our state and community are struggling to work through the difficulties caused by the weakened economy.
Now that the election rosters are being resolved, get ready. We are about to be exposed to the worst money can buy. The purpose: to inundate voters with anything and everything that will compromise the thought process.
Even before our neighbor, Casey Turpin, was killed at the intersection of Ga. 365 and Howard Road, my husband and I referred to that intersection as the intersection of death. Trying to cross or enter Ga. 365 there is to take your life in your hands.
The Georgia Department of Transportation must install a traffic light at the Howard Road/Ga. 365 intersection. Every day I pass this section of road coming to work and going home. Every day, patrons of Racetrac and the YMCA jet out into traffic moving at speeds of at least 65 mph, holding and drinking hot coffee, not paying attention, congregating in the median, desperate to get back on the road.
The black community was understandably outraged about what happened to Trayvon Martin. But I always thought that the main point of the protests and public outcry seeking "justice" was that the killing needed to be properly investigated and the shooter arrested.
Trying to implement a new policy for public speaking during work sessions was a valiant effort by Craig Lutz - sadly the first and probably only thing beneficial he's contributed to the county during his stay as commissioner.
It is a shame that the DOT has allowed Ga. 365 to become a killing zone because the intersections where side roads dump crossing and left-turn traffic onto a four-lane, 65 mph highway do not meet the criterion for a traffic light.
Dear Mr. Givens: Did they not offer any history classes where you went to school?
I know many of you are aware of the tragic killing of a young black man, Trayvon Martin, in Florida. I don't have the facts, nor do others, but it seems to me that the shooter is being tried and convicted before it ever reaches the court room.
All the commissioners need to be voted out of office. They have done nothing but ruined the lives of the poor and middle class. They've passed a storage of junk law that has people living in fear.
I met with two friends the other day and, with our mutual interest in city planning, the topic quickly turned to the great development potential for the Georgia Mountains Center area. Indeed, there is big potential.
During the race for the White House, the candidates seem to be picking on each other. President Barack Obama got his chance when Gov. Mitt Romney let everyone know that he put his dog in a cage and rode him on the top of the car one day. He said the dog liked it!
The purpose of this is not to pit down any team that plays for the Hall County Parks and Leisure Services leagues. It is to question the fairness of allowing travel teams to play in this league.
The GOP moderates have (quietly) spoken. Rick Santorum is out, Newt Gingrich is bankrupt and the party is not conservative.
So community and political organizers in the Latino and African-American communities have begun a push for district voting in Gainesville.
When I was a child, I was fascinated by the liturgy and art of the Roman Catholic Church. I would sneak into the living room on Christmas Eve and watch Midnight Mass from Rome. Being raised in a Baptist church in Southeast Arkansas, it was all so foreign! But something within it resonated within me.
In the midst of the current firestorm raging around the Confederate Battle Flag, intolerant, hate-filled voices demand the eradication of all things remotely associated with Confederate heritage. Quietly seeking but denied permission to be heard are the voices of reason which offer the love of Christ as the remedy for the angst afflicting American society at large.
On April 30, 1789, on Wall Street in New York City, the capital of the United States (at that time), Gen. George Washington had been sworn in as the first president. He and his government staff walked over to a little stone church, which is still standing today close to Ground Zero.
As I am called a bigot, a homophobe, and other names for my stance against gay marriage, I had an awakening thought: As people call me those names, they are also calling Jesus those names since He was the one who defined marriage as being between one man and one woman.
Now that the U.S. Supreme Court has rewritten the long-standing definition of marriage, the same-sex population and their supporters are gleeful while the rest of us are being labeled "intolerant, insensitive and hateful" for clinging to our archaic Biblical beliefs.
A huge thank you to BB&T for benefitting Randy and Friends through their Lighthouse Project. They spent many volunteer hours working to improve the Rooster's Perch Coffeehouse, in addition to the work space where employment and life skills are taught to adults with disabilities.
Concerning climate change, Pope Francis' stance in his Encyclical is very clear. He stated, "A very solid scientific consensus indicates that we are presently witnessing a disturbing warming of the climatic system," and "scientific studies indicate that most global warming is due to the great concentration of greenhouse gases released mainly as a result of human activity. Climate change is a global problem with grave implications."
I wanted to attend the Hall County budget meetings but couldn't. This is what I would have said:
The 2 percent, or less, of our population identified as LGBT are not being picked on. Rather, their bullying is being resisted. Nobody cares what other people are doing relationally in the privacy of their homes (no bomb building, please). We do care how our children are educated and about our Biblical values such as sanctity of marriage.
I have lots of words regarding Dick's column regarding our dad, but think only one is appropriate: Amen!
Last week, our country and our community received a command, not merely a call. We must reach deep inside our hearts and heads to find ways to reach people before they become unreachable, such as the young man responsible for the tremendous tragedy in Charleston.
The other day I read a small notice that our illustrious city council was considering "improving the square." I had lunch at the square the other day, sat outside and had a nice time just looking. I found the square looked very nice - nothing needs to be done.
Just like the Roman emperor Constantine did 1800 years ago, the "powers that be" continue to politicize Jesus for their own personal gain. And Christians continue to be vulnerable. Traditional theology hasn't helped much.
On more than one occasion, I have taken pen to paper to offer my criticism of your newspaper. It is expected that we subscribers will do that. When a newspaper does something that I feel is commendable, I will also offer my praise as well as extending my subscription another quarter.
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VIEWS: 45 PAGES: 2 CATEGORY: Medicine POSTED ON: 6/25/2010 Public Domain
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Nutrition1009.qxd 9/25/09 4:42 PM Page 1 42 Renal & Urology News OCTOBER 2009 www.renalandurologynews.com RENAL NUTRITION UPDATE Carnitine in HD Patients: An Update Carnitine treatment can improve erythropoietin resistance and other parameters BY ALISON STEIBER, PhD, RD, LD tine group had improved sensi- CARNITINE, a 3-hydroxy-4-N- tivity as measured by a euglycemic trimethylammoniobutanoate, is a insulin-clamp procedure. Addition- small, water soluble molecule found ally, this study used the stable in most cells of the body. The renal isotope leucine to demonstrate community has given much at- reduced proteolysis and net protein tention to this important molecule, catabolism with carnitine treat- but as yet there is no consensus on ment. This is the first study to whether carnitine treatment im- demonstrate these effects in HD proves outcomes in hemodialysis patients and may explain in part the (HD) patients. Early work done in nutritional improvements observed the 1980s tested a variety of hy- by Savica et al. potheses and various studies have Finally, two recently published examined the effect of carnitine studies using data from the Centers in HD patients. While some stud- for Medicare and Medicaid Ser- ies, such as those conducted by vices (CMS) and the Fresenius © JIM DOWDALLS / PHOTO RESEARCHERS, INC. Labonia et al (Am J Kidney Dis. Medical Care North America data- 1995;26:757-764) and Kletzmayr base to show carnitine treatment et al (Kidney Int. Suppl. 1999;69: reduces hospitalizations. In 2005, S93-106), clearly showed clinical Kazmi et al (Am J Nephrol. 2005; benefits, some studies were not as 25:106-115) found that a mean per- clear, such as a study conducted by treatment dose of 1.5 g for an aver- Sloan et al (Am J Kidney Dis. 1998; age of 9.7 months was associated 32:265-272). Recently published with a significant reduction in hos- work provides provocative data sug- In type 2 diabetes, glucose build up in the cell (shown above) is not moderated by pital stays. These results
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The best (and worst) times to be on the road in Ramadan
Put on your seatbelts, here we goJune 23, 2015 9:00
Register for our free newsletter
Abu Dhabi's Dana Gas hits 9-wk high after wins Kurdistan case
Saudi Telecom Co to pay Q2 dividend of 1 riyals/share
UAE non-oil business growth slows to 22-month low in June
MIDEAST STOCKS-Gulf likely to be subdued by oil price drop, Greece
Abu Dhabi's TAQA drops 5.4 pct after saying no merger talks
Qatar's Doha Bank raises 2 bln riyal Tier 1 capital-boosting bond
Dubai's Drake & Scull increases GCC ownership limit to 100 pct
Abu Dhabi's TAQA says not holding merger talks
Gold languishes below $1,170 ahead of U.S. jobs data
Kuwait parliament approves budget with $27 billion deficit
Deeyar's selling property, Al Manal is getting financing and Nakheel's paying up—Kipp couldn't ask for a more positive looking property world, if we wanted to.
March 30, 2011 3:41 by Eva Fernandes
Property in Dubai-wait, are you waiting for some sorry testimony to just how awful the property scene in Dubai really is, what with rents dropping, debts increasing and construction stopping?
Well, because Kipp's in a pretty good mood we bring you the flip side of the equation to prove to you that not everything is as bad as it seems.
Take for instance the case of Deyaar Development who reportedly sold more than Dh2.2 billion worth of property and land. Though, it probably does Kipp well to note that while Deyaar said it sold its property to an unnamed "related party", which analysts speculate is Dubai Islamic Bank (DIB) – which would mean nothing, except that Dubai Islamic Bank is 40 percent-owned by none other than Deyaar.
Either way Deyaar is looking forward. Saeed al Qatami, the acting Deyaar chief executive told The National: "As we enter a period of increased stability in the UAE property sector, in line with more positive macroeconomic conditions, Deyaar now looks to 2011 with renewed confidence, as well as with an enduring focus on customer care and service innovation."
Ok, so maybe not as impressive as we promised, but hey give us a second chance, will you?
How about Al Manal Development? Just this week, it has become the first real estate developer to secure a two-year funding of Dh65 million from Mashreq for its Lakeside Residence in Jumeirah Lakes Towers.
Pages: 1 2
Battle of the news channels
March 30 2011
Magic marker, anyone? None for Kipp, thanks.
March 30 2011


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Cool hidden features in Windows 8.1
Jun 26, 2013 6:51 PM
Latest Videos
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The future of mobile devices is blazing fast, ultrasonically secured, and charged by the sun.
Intel CEO wants to crack the mobile market
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SanDisk new microSD card packs a whopping 200GB of storage
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Here's how Samsung made TouchWiz better on the Galaxy S6
Samsung drastically pared down how much bloatware it packs into its TouchWiz Nature UX, though this adaptation of Android Lollipop is still kinda blue.


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Math teachers get refresher course
When school resumes this fall, hundreds of north Mississippi students will get a fresh look at mathematics as an exciting, everyday tool, thanks to a recent two-week training institute conducted by the University of Mississippi's Center for Mathematics and Science Education.
Using a $1.5 million grant from the Mississippi Department of Education, CMSE developed the summer program, dubbed Project PrIME, or Promoting Innovation in Mathematics Education, to help teachers improve their content knowledge in mathematics. Sixty middle school teachers from across north Mississippi participated in the inaugural summer institute earlier this month at Della Davidson Elementary School in Oxford.
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Utah author Brandon Sanderson set to release final installment of much-loved Wheel of Time series
The final installment in a fantasy book series that has spanned more than two decades is about to hit bookstores.
The 14th and final book of the Wheel of Time series "A Memory of Light," (Tor, $34.99) by the late Robert Jordan and local Utah author Brandon Sanderson will be released Jan. 8. The final book marks the passing of a much-loved epic fantasy story and the end of a period when a single book could span 2 or more inches thick on bookstore shelves.
The Wheel of Time series was created by James Oliver Rigney Jr. under the pen name Robert Jordan in 1984. The first book was published in 1990. Jordan's series tells the story of a fantasy world in which the Dark One, the embodiment of pure evil, is breaking free of his prison. One man learns he is the world's messiah reincarnated and destined to save the world from the Dark One. But he also learns he could destroy the world in the process.
Audio excerpt from "A Memory of Light"
The series is the story of an entire world's struggle to deal with evil, change and hope. Jordan's series quickly mastered the epic fantasy genre as book after book was published. Books 8 through 13 reached No. 1 on The New York Times Best Seller List.
When Jordan died while writing the 12th and final book of the series in 2007, Harriet McDougal, Jordan's widow, selected Sanderson to finish the series for Jordan posthumously. Sanderson had published "Elantris" and the first two books of his Mistborn series through the same publisher as Jordan, Tor Books. The announcement was made in December 2007 and soon after Sanderson began working on the series.
He quickly discovered that the last book couldn't possibly tie up all the loose ends of the story in the length of one book, so he split the final book into three installments, the last of which is being released on Jan. 8.
While working on the Wheel of Time, Sanderson decided to adapt his style to the series — but not copy Jordan's style. "As a writer, you learn different styles just like a painter learns to paint in different styles, and the Wheel of Time uses a more descriptive style than I use on my own, and I thought it would be more appropriate to try and do that," said Sanderson.
When selected to finish Jordan's series, Sanderson says he was given full creative power to do whatever he felt he needed to make the story work. Even though he could have altered it to make it more his own, Sanderson wanted to try to do it as Jordan's story.
"My goal wasn't to come into this and in any way 'fix' the Wheel of Time or the outline. I wanted to do it the way that he (Jordan) wanted it done," said Sanderson.
According to Sanderson, writing someone else's novel was far more difficult than writing his own.
"I would spend about twice as much time on a given scene that I wrote for a Wheel of Time book than I spend on my own because there's so much continuity to be aware of." Although Sanderson put a lot of his own projects on hold while writing the Wheel of Time books, he says he'll miss working on them.
The Wheel of Time books have been with him almost his whole life, Sanderson said.
"I picked up the first book in 1990 — I was 14 years old — and I have been reading the Wheel of Time books ever since. It's been 23 years that I've had the Wheel of Time books. It's been there basically through my whole life and this is the end and all good things do have an ending, and the ending comes. A piece of art isn't right until it's finished and so it's a good thing, but it's also a really sad thing."
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Topic: Jack In The Box
Quiz: Can You Match the Fast-Food Chain With Its Old-School Tagline?
McDonald's, Burger King, Arby's and more
By Katie Richards on Jun. 11, 2015 - 3:42 PM EDT
It's hard to forget a fast-food chain's tagline. The ads are everywhere, the restaurants are everywhere and those jingles are so darn catchy. But long after they're gone, can you…
Jack in the Box Unveils the World's Largest Coupon, an 8-Story-High Monstrosity
And photographs of it are redeemable
By David Kiefaber on Mar. 31, 2015 - 11:34 AM EDT
I'm sure we've all had some unflattering theories about how Jack in the Box would achieve a Guinness World Record ("Most People Made Uncomfortable by Creepy Mascot" was my guess).…
10 Ad Mascots You Probably Didn't Know Were Related to Kermit the Frog
The many commercial creations of Jim Henson's Creature Studio
By Garett Sloane on Nov. 15, 2014 - 8:21 AM EST
Jim Henson creations have a storied history in advertising, going back to the 1950s, when a violent proto-Kermit pitched Wilkins Coffee with 10-second TV spots. Tappy, the latest creation from Jim…
Facebook Music App Gets Jack In The Box Jumping
Absolut also has tested the marketing feature
By Christopher Heine on Oct. 16, 2013 - 11:54 AM EDT
Jack In The Box has launched a Facebook app that lets viewers search for tunes and click through to Spotify—if they are signed up with the digital music service—to get…
Jack in the Box Gets Back to Tacky Humor With Giant Chickens and Sexting
Sophomoric gags prevail
By David Gianatasio on Aug. 9, 2013 - 1:00 PM EDT
Secret Weapon Marketing's latest terrifically tacky effort for Jack in the Box features big-ass chickens, highway smash-ups and sexting—though, perhaps sadly, not in the same commercial. Three spots tout the…
Lakers' Losing Streak Forces Taco Time-Out
Jack in the Box promotion tied to winning games has L.A. basketball fans going home hungry
By Michael Ventre on Jan. 29, 2013 - 7:13 AM EST
With 2:05 left in the third quarter of a recent game at Staples Center between the Los Angeles Lakers and the visiting Oklahoma City Thunder, public address announcer Lawrence Tanter…
Don't Get 'Nugged' for Your Nuggets, Warns Jack in the Box
It's OK, your backpack will be fine
By David Kiefaber on Jan. 3, 2013 - 10:21 AM EST
With "nugging," Jack in the Box may think it's invented a cute new slang term for the act of stealing someone's chicken nuggets. But apparently nugging is already a thing.…
Jack in the Box: If You Love Bacon, Why Don't You Marry It?
The latest love song to pig shavings
By David Kiefaber on Feb. 3, 2012 - 8:40 AM EST
Jesus Christ, it never ends. Jack in the Box takes America's (literally) unhealthy bacon obsession to the next level with its "Marry Bacon" TV commercial from Secret Weapon Marketing, which…
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Spot leaks tomorrow to select consumers
By Tim Peterson on Feb. 2, 2012 - 4:06 PM EST
Jack in the Box thinks consumers will love its new BLT Cheeseburger so much they'll want to marry it—at least that's the premise of the quick-service restaurant chain's regional Super…
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By Andrew McMains on Dec. 15, 2011 - 12:31 PM EST
As Jack in the Box heads into the new year, the fast-food chain looks to deepen its digital connections with customers. Such is the core task facing new lead digital shop…


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Top 5 2013 NFL Draft Sleepers: Offense
2013 NFL Draft Sleepers-Offense
The NFL draft is the ultimate talent competition in all of professional sports. These athletes spend their college careers in essence auditioning for the annual April event. And while many players leave college football only hoping to be selected somewhere, for others it's about being selected early in the draft that becomes their priority.
And while it's clear that if you look at the rosters of Pro Bowl players and All-Pros, it's without question that most of those players are drafted in the first two rounds of the draft. However, if you look across all 32 NFL rosters, the bulk of teams are built on mid to late round players. There is an old saying that says you can't have an All-Pro at every position. And because that is true, the job of an NFL scouting department and personnel staff has to not only decide which players best fit their teams for the early selections, but the middle of the draft, when it gets much harder to identify the real gems is how they make their money.
So, let's take a look at five guys on offense who almost certainly will not be selected in the top two rounds of the 2013 NFL draft, but have all the makings of future NFL stars. These players will slip in April for a variety of reasons, whether it's level of competition in college, lack of quality film, injury concerns, or simply being a good player on a very bad team.
So let's break down the top five sleepers on offense for the 2013 NFL Draft.
Curt covers the Pittsburgh Steelers, NFL draft, and college football for Rant Sports. Connect with him on Twitter @nfldraftboard for even more football ramblings.
Brad Sorensen, QB Southern Utah
Brad Sorensen, quarterback
Southern Utah
Height 6-5 Weight 230lbs
If Sorensen played for a major BCS program, he'd be discussed among the very top quarterbacks in this class. But because he has played for the Thunderbirds of Southern Utah, he has gotten a little caught up in the mix. However, in a quarterback draft class where every quarterback has some concerns, Sorensen is pretty darn clean. He's got ideal size, a tremendous arm and plays with a ton of confidence. One thing he has shown that impresses me is his ability to work through his progressions and see the entire field. It's not a case of one read and force the throw if it's not there. He can look off a safety and sling it down field.
In terms of a grade, I have Sorensen as a 4th round prospect. I think that would be a really nice value, especially for a team that has a starter in place and can allow him to develop and pick up the speed of the game initially as a backup.
Dennis Johnson, RB Arkansas
Dennis Johnson, running back
Height 5-9 Weight 214lbs
Johnson is one of those players who takes a big hit in draft status, like his teammate quarterback Tyler Wilson, because of all the problems the Arkansas football program had to deal with last season. Johnson was probably the team's most consistent offensive weapon for the Razorbacks all season. He's got an ideal physical body for the NFL with great power and quickness and a low center of gravity. He runs with great pad level and nice quickness. If you compare his best runs with the best runs of the top running backs in this draft, there's very little difference in skills.
The one negative to Johnson's game is that he does lack elite sprinter speed that so many teams covet. He's not going to break off a lot of 70 yard runs, but he grinds and gets yards after contact, and will keep moving the chains as a rusher and receiver. Running back is normally pretty undervalued so don't be surprised if he slides to the 5th or 6th round but outplays backs taken ahead of him.
Omarius Hines, WR Florida
Omarius Hines, wide receiver
University of Florida
Height 6-2 Weight 220lbs
Hines is one of those players who just was never able to get his game on track this past season for the Gators. Florida used a run heavy offense and the passing skills of the Gators quarterbacks were questionable so his stats have never supported his talent. Hines has great size with a strong build and his game can be described the same way. He's a very physical matchup for defenses and his build lets him line up in multiple spots in the offense.
Hines isn't an ideal body type for an outside wide receiver and so that will push him down late in the draft. He also isn't going to wow teams with elite speed and acceleration. But his potential is much higher than most give him credit for. He's got great hands and runs very nice routes. He has the look of a great red zone target as a slot WR/H-back type of prospect in the 5th or 6th round.
Chris Faulk, OT LSU
Chris Faulk, offensive tackle
Height 6-6 Weight 330lbs
Faulk entered the 2012 season as a potential first round pick, but one game into the season he was lost for the year with a knee injury. A lot of players would have returned to school, but Faulk was concerned about another injury, so he went ahead and declared as a junior. Going back to the 2011 film on Faulk you see what a mauling run blocker he is, but his draft status will slide because teams aren't sure if he'll be ready to play in 2013, whether it's health or level of fitness. But assuming he can get well and be ready to play in either 2013 or 2014 his ability to run block is as good as any in this draft. His future in the NFL might be at guard where he can operate in a small area, but there's almost no risk to a 6th or 7th round pick on a player with this much potential and film to match.
Vance McDonald, TE Rice
Vance McDonald, tight end
Height 6-4 Weight 260lbs
McDonald is starting to get people talking, so I won't be shocked if he's not a 3rd round pick by April. He's a huge target and a very good blocker in space, but his effort in the passing game is what teams like. He uses his body well, and pushes defenders around, fighting to get open and making the challenged catch.
McDonald is the Owls offense spend the majority of his time split out wide, which NFL teams will like as a receiver, but he's pretty untested lining up in a 3 point stance next to a tackle and blocking a defensive end. Most of his blocking came against safeties and cornerbacks, so his strength at the point of attack against big boys will be a real challenge. But he's a solid receiver split out wide and get good yards after the catch. He's not a deep threat but has the look of a good red zone target and the kind of tight end who would be clutch on 3rd downs.
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Can I backup the TC to the cloud (i.e. make an online backup of the data on the TC)?
I would like to follow Peter Krogh's recommendation of keeping 3 copies of important files, a primary and two back-ups, with one of the back-ups being offsite. (i.e. The 3-2-1 Rule) Can I backup all my MACs to the TC and then backup the TC to online backup site?
- Asked by Brian P from Schwenksville
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You can. However, copies of backups may be inaccurate and are not recommended.
Keep in mind that a Time Machine backup is twice the size of all the data, at least some of which was not the original, anyway.
- Answered by Andrew H from Carmel


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VCOSS Consultation: Shaping the education state and the Bracks review
- Community & Culture
- Level 8, 128 Exhibition St, Melbourne, VIC, 3000
VCOSS Sector Reform Consultation: Bendigo
VCOSS Events
Wednesday, 10 September 2014 from 1:00 PM to 3:30 PM (AEST)
In September and October, the Victorian Council of Social Service (VCOSS) is hosting a series of consultations with community sector organisations across the state regarding the principles and priorities for the Community Sector Reform Council. The consultations will provide participants with an opportunity to discuss the objectives of the Reform Council and provide feedback and direction of the work of the Reform Council going forward.
The audience for these sessions are representatives from community sector organisations. VCOSS will be hosting seven consultations across the state and inviting members of the Reform Council to join each session and discuss the work of the Reform Council with participants.
We invite our members, leaders and representatives from community sector organisations to participate and help inform the work of the Community Sector Reform Council.
This consultation will be:
Date: Wednesday 10th September 2014
Time: 1:00pm to 3:30pm
Where: Bendigo Bank Theatre
The Capital, Bendigo Performing Arts Centre
50 View Street
Bendigo VIC 3550
For further enquiries please contact VCOSS on 03 9235 1000 or email firstname.lastname@example.com
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GRAMMY Charity Online Auctions Will Include VIP Justin Bieber Experience
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Proceeds from GRAMMY Charity Online Auctions provide essential support for the GRAMMY Foundation. Under the banner of GRAMMY in the Schools®, the GRAMMY Foundation produces a range of distinct education programs - across the country throughout the year - that serve high school students and their schools including GRAMMY Camp®,GRAMMY Camp - Basic Training, GRAMMY Camp - Jazz Session, and GRAMMY Signature Schools. The GRAMMY Foundation also offers preservation and advancement initiatives, fosters dialogue about compelling issues facing the music industry, supports projects that increase the understanding of music and its role in society, and raises public awareness about the urgent need to preserve our nation's recorded sound legacy. These programs include the Entertainment Law Initiative®, the Grant Program with funding generously provided by The Recording Academy®, the Living Histories program, and the Music Preservation Project.
GRAMMY® Charity Online Auctions now include an exclusive VIP experience with Justin Bieber, available through Nov. 2 at www.ebay.com/grammy. All proceeds will benefit the GRAMMY Foundation.
The GRAMMY Foundation was established in 1989 to cultivate the understanding, appreciation and advancement of the contribution of recorded music to American culture - from the artistic and technical legends of the past to the still unimagined musical breakthroughs of future generations of music professionals. The Foundation accomplishes this mission through programs and activities that engage the music industry and cultural community as well as the general public. The Foundation works in partnership year-round with its founder, The Recording Academy®, to bring national attention to important issues such as the value and impact of music and arts education and the urgency of preserving our rich cultural heritage. Campbell's Labels for Education program is proud to be the official education partner of the GRAMMY in the Schools programs. For more information, please visit www.grammyintheschools.com. For breaking news and exclusive content, please like "GRAMMY in the Schools" on Facebook atwww.facebook.com/grammyintheschools and follow @GRAMMYFdn on Twitter atwww.twitter.com/GRAMMYFdn.
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A story for you. This story has been told to me many times by various members of my extended family.
One night, my great grandmother S was faithfully praying her rosary, when she saw a devil run through her room and up into her attic. This devil was about 5 inches tall and fiery red (as devils tend to be). Being the brave Catholic that she was, she followed him up into the attic. Once there, she saw the little devil laughing and screaming curses at her. Unfazed, grandma S squirted it with holy water (or threw a bible at it, depending on who you ask) and much like the wicked witch of the west, that little devil dissolved, screaming and cursing as he went.
People in my family actually believe this story. Just wanted to share the crazy and see what kind of family legends some of you may have!