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Publications (46)207.03 Total impact
Article: Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP trial): a multicentre, randomised, double-blind, placebo-controlled trial[Show abstract] [Hide abstract]
ABSTRACT: Immune thrombocytopenia is characterised by immune-mediated destruction and suboptimum production of platelets. Despite the absence of supporting evidence, rituximab is frequently used off-label in patients with immune thrombocytopenia. We aimed to assess the efficacy of rituximab as compared with placebo as a splenectomy-sparing treatment in patients who were previously treated with corticosteroids. In this multicentre, randomised, double-masked, placebo-controlled trial, we enrolled corticosteroid unresponsive adult patients (aged ≥18 years) with primary immune thrombocytopenia and a platelet count of less than 30 × 10(9) platelets per L. Patients were randomly assigned (1:1) to four weekly infusions of 375 mg/m(2) rituximab or placebo. Concurrent treatment with corticosteroids only was allowed during the study. The primary endpoint was rate of treatment failure within 78 weeks-a composite of splenectomy or meeting criteria for splenectomy after week 12 if splenectomy was not done, assessed in all patients who received at least one dose of study treatment. Secondary endpoints were response rates, relapse rates, and duration of response. Efficacy endpoints were assessed with the Kaplan-Meier method. Safety endpoints were assessed in all patients who received at least one dose. This trial is registered with ClinicalTrials.gov, number NCT00344149. Between Aug 17, 2006, and June 30, 2011, we enrolled 112 patients. 32 (58%) of 55 patients in the rituximab group and 37 (69%) of 54 patients in the placebo group had treatment failure within 78 weeks (Kaplan-Meier cumulative incidence 46% for rituximab vs 52% for placebo (hazard ratio [HR] 0·89, 95% CI 0·55-1·45; p=0·65). The cumulative incidence of overall response was 81% in the rituximab group versus 73% in the placebo group (p=0·15) and complete response was 58% in the rituximab group versus 50% in the placebo group (p=0·12). Of those achieving an overall response, 68% relapsed in the rituximab group and 78% relapsed in the placebo group, and of those achieving complete response, 50% relapsed in the rituximab group and 62% relapsed in the placebo group. Time to relapse in the rituximab group was longer in patients who achieved overall response (36 vs 7 weeks; p=0·01) but not complete response (76 vs 49 weeks; p=0·19). Rates of bleeding were similar in the two groups (21 [38%] in the rituximab group vs 27 [50%] in the placebo group; p=0·08) as were rates of infection (22 [40%] vs 13 [24%]; p=0·09). Despite no reduction in the rate of long-term treatment failure with rituximab, a small benefit cannot be ruled out, as suggested by an apparently longer duration of response and numerically higher response rates with rituximab. South-East Regional Health Authority and Østfold Hospital, Norway; Roche, France; and Roche, Norway. Copyright © 2015 Elsevier Ltd. All rights reserved.The Lancet 02/2015; 385(9978). DOI:10.1016/S0140-6736(14)61495-1 · 45.22 Impact Factor
Article: Monitoring bypassing agent therapy – a prospective crossover study comparing thromboelastometry and thrombin generation assay[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to evaluate the capability of thromboelastometry (ROTEM) and thrombin generation assay (TGA) to monitor the treatment response of bypassing agent (BPA) therapy and to study whether one method is superior to another. In a prospective crossover study haemophilia A patients with high titre inhibitors were included to receive a dose of 75 U kg(-1) activated prothrombin complex concentrates (aPCC) intravenously. Blood sampling was performed at baseline, 15, 30 min, 1, 2, 3 and 4 h post-infusion for TGA and ROTEM analysis. After a washout period of 14 days the subjects received recombinant FVIIa (rFVIIa) at a dose of 90 μg kg(-1) and similar blood sampling was performed. Healthy subjects were used as controls. Six haemophilia A patients with inhibitors were included. We found that TGA parameters endogenous thrombin potential (ETP) and peak thrombin increased 2-3 folds from baseline 15-30 min after infusion. ROTEM parameters MaxVel and maximum clot firmness increased to a level comparable to that of healthy controls. An individual difference in response was observed for different parameters among participants. ETP and peak thrombin were almost two-fold greater following aPCC infusion compared to rFVIIa, whereas ROTEM parameters showed no difference in response between the two products. The study showed that ROTEM and TGA have a great potential to evaluate the effect of BPA in haemophilia patients with inhibitors. TGA seemed to be more sensitive than ROTEM in reflecting the difference in treatment response between aPCC and rFVIIa. Additional prospective clinical studies are needed to clarify which assay and what parameters are clinically predictive. © 2014 John Wiley & Sons Ltd.Haemophilia 12/2014; 21(2). DOI:10.1111/hae.12570 · 2.47 Impact Factor
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ABSTRACT: BACKGROUND Allogeneic stem cell transplantation (ASCT) has been a treatment option for patients with serious diseases of the blood and haematopoietic organs in Norway since 1985. Such treatment is potentially curative for selected patients who have a relatively short predicted survival with other treatment modalities. This article summarises the experience and results from ASCT at Oslo University Hospital Rikshospitalet.MATERIAL AND METHOD The study included all of the 734 adult patients who had undergone allogeneic stem cell transplantation at the Department of Haematology, Rikshospitalet, later Oslo University Hospital Rikshospitalet, from November 1985 to October 2012.RESULTS At the time of analysis, altogether 384 patients were alive, and the five and ten-year survival rates were 54 % and 48 % respectively. The median follow-up time was six years. A total of 339 patients (46 %) had developed acute graft-versus-host disease (GvHD), and 250 (73 %) of these had GvHD ≥ grade II. Altogether 280 out of 602 patients who lived ≥ 100 days after the transplantation (46.5 %) developed chronic GvHD. The most frequent causes of death included recurrence of the initial disease in 116 patients (33.1 %), multi organ failure after transplantation in 88 patients (25.4 %), infections in 54 patients (16 %) and GvHD in 33 patients (9.4 %).INTERPRETATION ASCT is a treatment option with a curative potential for patients with serious haematological diseases when other forms of treatment provide few prospects for recovery. The total survival rate in our study is in accordance with international results for the same time period, and the indications have consistently been in line with what is accepted internationally.
Article: [In Process Citation].
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ABSTRACT: Stormorken syndrome is a rare autosomal dominant disease with mild bleeding tendency, thrombocytopathy, thrombocytopenia, mild anemia, asplenia, tubular aggregate myopathy, miosis, headache and ichthyosis. A heterozygous missense mutation in STIM1 exon 7 (c.910C>T; p.Arg304Trp) (NM_003156.3) was found to segregate with the disease in six Stormorken syndrome patients in four families. Upon sensing Ca2+ depletion in the endoplasmic reticulum (ER) lumen, STIM1 undergoes a conformational change enabling it to interact with and open ORAI1, a Ca2+ release-activated Ca2+ (CRAC) channel located in the plasma membrane. The STIM1 mutation found in Stormorken syndrome patients is located in the CC1 domain, which might play a role in keeping STIM1 inactive. In agreement with a possible gain-of-function mutation in STIM1, blood platelets from patients were in a pre-activated state with high exposure of aminophospholipids on the outer surface of the plasma membrane. Resting Ca2+ levels were elevated in platelets from the patients compared to controls, and store-operated Ca2+ entry was markedly attenuated, further supporting constitutive activity of STIM1 and ORAI1. Thus, our data are compatible with a near maximal activation of STIM1 in Stormorken syndrome patients. We conclude that the heterozygous mutation c.910C>T causes the complex phenotype that defines this syndrome. This article is protected by copyright. All rights reservedHuman Mutation 05/2014; 35(5). DOI:10.1002/humu.22544 · 5.05 Impact Factor
Article: Tranexamic acid as adjunct therapy to bypassing agents in haemophilia A patients with inhibitors[Show abstract] [Hide abstract]
ABSTRACT: Haemophilia patients with inhibitors require bypassing agents (BPA) like activated prothrombin complex concentrate (aPCC) and recombinant activated factor VII (rFVIIa) to control bleeds. Adjunct tranexamic acid (TXA) may improve haemostasis. The objective of this study was to investigate safety and haemostatic effect of TXA given in combination with BPA. Healthy volunteers (N = 5) and haemophilia inhibitor patients (N = 6) were enrolled in a prospective case crossover design. Controls were treated with TXA 20 mg kg(-1) orally (O.R.) Patients were treated with aPCC 75 IU kg(-1) intravenous (I.V.) on day 1 followed by TXA 20 mg kg(-1) O.R. combined with aPCC 75 IU kg(-1) I.V. on day 2. A 14-day washout occurred before crossover to rFVIIa 90 μg kg(-1) I.V. ±TXA. Safety evaluation and blood sampling processes were performed at baseline, 15, 30, 60, 120, 180 and 240 min post treatment. Primary outcome was maximum clot firmness (MCF) evaluated by whole blood thromboelastometry using a TF + tissue plasminogen activator-based assay. Healthy controls showed a 20-fold increase in MCF following TXA. Adjunct TXA to aPCC or rFVIIa induced a significant increase in MCF (P < 0.0001) reaching levels indistinguishable from healthy controls treated with TXA (P > 0.05). Infusion of aPCC or rFVIIa alone induced only 3-10 fold increase in MCF from baseline, with a decline in MCF starting after 60-120 min. TXA did not increase the endogenous thrombin potential. No clinical or laboratory signs of thromboembolic events, disseminated intravascular coagulation, or hypercoagulability were observed. Combination of aPCC or rFVIIa with TXA normalizes clot stability in haemophilia patients with inhibitor as compared to healthy controls. No clinical or laboratory adverse events were observed.Haemophilia 11/2013; 20(3). DOI:10.1111/hae.12318 · 2.47 Impact Factor
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ABSTRACT: Arthropathy of the knee is a frequent complication in patients with severe bleeding disorders leading to considerable pain and disability. Total knee arthroplasty (TKA) provides marked pain relief. However, a modest functional outcome and a high number of complications due to prosthetic infection and loosening are reported. Data on long-term outcomes are scarce, and most case series include few patients. We have studied clinical outcomes and complications of TKAs with special emphasis on prosthetic survival and periprosthetic infection. A consecutive series of 107 TKAs in 74 patients with haemophilic arthropathy were retrospectively reviewed. Follow-up was mean 11.2years (range 0.8-33.1years). Five- and 10-year survival rates, with component removal for any reason as the end point, were 92% and 88%, respectively. Twenty-eight TKAs were removed after median 10years (range 0.8-28years). The most common cause of failure was aseptic loosening (14 knees) and periprosthetic infection (seven knees). The overall infection rate was 6.5%. The mean postoperative drop in haemoglobin levels was 4.3g/dL (range 0.5-9.4) with a significant difference between haemophilia A patients with and without inhibitor (6.3g/dL (range 3.6-9.4) versus 3.7g/dL (range 0.5-8.1) (p<0.001). A painless knee was reported in 93% of the TKAs at the latest follow-up. The medium and long-term results of primary TKA in a large haemophilic population show good prosthetic survival at five and 10years with an excellent relief of pain. Periprosthetic infection is still a major concern compared to the non-haemophilic population. Level IV.The Knee 10/2013; 21(1). DOI:10.1016/j.knee.2013.09.010 · 1.70 Impact Factor
Article: Use of thromboelastography and thrombin generation assay to predict clinical phenotype in patients with severe FVII deficiency[Show abstract] [Hide abstract]
ABSTRACT: Bleeding tendency is weakly correlated with the activity of factor VII (FVII) in the plasma of patients with FVII deficiency. A laboratory method for predicting bleeding risk in patients with this coagulation disorder is lacking. We investigated whether global coagulation assays, specifically thromboelastography (TEG) and thrombin generation assay (TGA), could be used to predict bleeding risk. We also sought to identify factors that may explain the differences in bleeding phenotype observed among individuals with severe FVII deficiency. The study comprised 12 patients with severe FVII deficiency (FVII activity <1%). Eleven patients were homozygous for the Gln100Arg mutation and one patient was compound heterozygous. Clinically, 10 patients had increased haemorrhagic diathesis, whereas two patients were asymptomatic. Blood sampling was performed at baseline for TEG and TGA analyses. The platelet aggregation assay was performed and the plasma level of anticoagulation inhibitors and thrombophilic risk factors assessed. No difference in the TEG and TGA results was observed in all FVII-deficient individuals. The level of free tissue factor pathway inhibitor was within the normal range and similar in symptomatic and asymptomatic subjects. None of the participants had the FV Leiden mutation, prothrombin gene mutation, or abnormal anticoagulant inhibitor levels. Asymptomatic subjects showed normal platelet aggregation. These data suggested that TEG and TGA were not suitable methods for predicting the clinical phenotype in FVII-deficient subjects.Haemophilia 08/2013; 20(1). DOI:10.1111/hae.12256 · 2.47 Impact Factor
Article: Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect[Show abstract] [Hide abstract]
ABSTRACT: Prophylaxis with plasma-derived or recombinant activated factor VII is beneficial in severe factor VII deficiency. To understand why prophylactic treatment with both products is efficacious, we conducted a pharmacokinetic study. Ten factor VII deficient patients were treated with either recombinant activated (20μg/kg) or plasma-derived (25IU/kg) factor VII in a cross-over design. Pharmacokinetic parameters were analyzed through activated factor VII activity, factor VII clotting activity, and factor VII antigen levels on depicted time points. Factor VII activity half-lifes, determined by non-compartmental and one-compartmental analysis (results in brackets), were shorter for recombinant activated (1.4h; 0.7h) than for plasma-derived factor VII (6.8h; 3.2h); both recombinant activated (5.1h; 2.1h and plasma-derived factor VII (5.8h; 3.2h) resulted in longer half-lives of factor VII antigen. Activated factor VII half-lives (based on activated factor VII activity levels) were significantly higher compared to factor VII clotting activity (1.6h; 0.9h). Volumes of distribution were significantly higher for activated factor VII (236ml/kg; 175ml/kg, measured by activated factor VII) as compared to plasma-derived factor VII (206ml/kg; 64ml/kg, measured by factor FVII activity), suggesting a plasma- and extracellular fluid distribution for recombinant activated factor VII. Recombinant activated factor VII showed significantly shorter half-lifes than plasma-derived factor VII. Volumes of distribution were significantly higher for treatment with recombinant activated factor VII. The longer half-life for plasma-derived factor VII, compared to recombinant activated factor VII, and the increased volume of distribution for recombinant activated factor VII, compared to plasma-derived factor VII may further elucidate the beneficial effect of prophylactic treatment of both products.Thrombosis Research 07/2013; 132(2). DOI:10.1016/j.thromres.2013.05.027 · 2.43 Impact Factor
Article: Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients[Show abstract] [Hide abstract]
ABSTRACT: Recombinant activated factor VII (rFVIIa) and plasma-derived factor VII (pdFVII) are used to prevent bleedings in severe FVII deficient patients, despite their short half-lifes. It is suggested that FVII levels of 15-20IU/dL are sufficient to maintain hemostasis. We analyzed the pharmacodynamic effects of FVII substitution therapy in the Nijmegen Hemostasis Assay (NHA) that simultaneously measures thrombin and plasmin generation. Ten severe FVII deficient patients were treated with 20μg/kg rFVIIa or 25IU/kg pdFVII in a cross-over design. Thrombin generation lag-time (TG-LT) was identified as an effect-response parameter. Pharmacodynamic analysis using a maximum effect model showed 50% reduction of the TG-LT effect at ~2IU/dL FVII activity for both rFVIIa and pdFVII. The FVII activity to obtain TG-LT comparable to the upper limit of normal range in healthy controls (4min) was given by the effective concentration (ECnormal), showing sufficient hemostasis at 3-4IU/dL FVII activity. No association was seen between FVII activity and other thrombin or plasmin generation parameters as measured by NHA. In conclusion, 3-4IU/dL FVII activity seems sufficient to maintain hemostasis in patients with severe FVII deficiency during prophylaxis. These data may suggest a potential value for measurement of TG-LT in the monitoring of FVII(a) therapy.Thrombosis Research 05/2013; 132(1). DOI:10.1016/j.thromres.2013.04.021 · 2.43 Impact Factor
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ABSTRACT: Continuous infusion (CI) of factor VIII (FVIII) is an effective method for replacement therapy in haemophilia. Recently, concerns have been raised regarding association of CI with the development of inhibitors. The aim of this study was to gain information on the current practices in Europe regarding CI and the true inhibitor incidence after this mode of therapy. In a cross sectional study performed in 22 Comprehensive Care Centres (CCCs), we evaluated CI techniques, treatment protocols, efficacy, safety and complications of CI including inhibitors. Thirteen (59%) CCCs reported a total of 1079 CI treatments, given peri-operatively or for major bleeds, in 742 patients. Most centres used 'adjusted dose' CI aimed at median target FVIII level of 0.8 IU mL(-1). CI was haemostatically very effective with a low incidence of complications: median incidence of postoperative bleeding was 1.8%, six centres observed phlebitis in 2-11% of CI treatments. Only nine (1.2%) patients developed inhibitors (0.45% of 659 severe and 7.2% of 83 mild haemophilia patients). Additional analysis of inhibitor patients revealed several confounding factors (low number of prior FVIII exposure days, high steady-state factor levels during CI, high-risk genotype). In this unprecedentedly large cohort, CI treatment appears to be an effective and safe treatment that does not increase the risk of inhibitor development in patients with severe haemophilia. Thus, previous small case series reports suggesting that CI may increase inhibitors cannot be confirmed. Inhibitor risk in mild haemophilia could not be evaluated as the influence of other, potentially confounding, risk factors could not be excluded.Haemophilia 04/2012; 18(5):753-9. DOI:10.1111/j.1365-2516.2012.02810.x · 2.47 Impact Factor
Article: Combined treatment with APCC (FEIBA (R)) and tranexamic acid in patients with haemophilia A with inhibitors and in patients with acquired haemophilia A - a two-centre experience[Show abstract] [Hide abstract]
ABSTRACT: The management of bleeding in haemophilia patients with inhibitors can be challenging when using monotherapy with either activated prothrombin complex concentrate (APCC) or recombinant activated FVII (rFVIIa) fail. The antifibrinolytic agent tranexamic acid (TXA) increases clot stability and is used concomitantly with coagulation factor replacement to improve haemostasis in haemophilia patients without inhibitors in many countries in Europe. Combined treatment with TXA and rFVIIa is not contraindicated in haemophilia patients with inhibitors. However, the combined approach of TXA and APCC has not been investigated due to safety concerns of increased risk of thrombosis or disseminated intravasal coagulation (DIC). The aim of this study is to report our experience of concomitant use of APCC and TXA in haemophilia A patients with inhibitor and in patients with acquired haemophilia A with respect to safety and efficacy. Seven (n = 6) haemophilia A patients with inhibitors and one (n = 1) with acquired haemophilia A from Oslo (Norway) and Stockholm (Sweden) were included in the study. The APCC was given at doses consistent to the manufacturers' recommendation. TXA was administered concomitantly either 10 mg kg(-1) every 6-8 h intravenously or 20 mg kg(-1) every 6-8 h orally. Haemostatic response was assessed by thromboelastography (TEG) and thrombin generation assay (TGA) in three of the patients. A total number of three bleeding episodes and two minor and six major surgical procedures were performed under the coverage with APCC and TXA. Haemostatic outcome was rated excellent or good in 10 of 11 (91%) treatment episodes. One episode was rated with poor effect. No episodes of arterial, venous thrombosis or DIC occurred during or after the treatment. Data from TEG and TGA analysis showed no signs of hypercoagulability following the combined treatment. This report demonstrates that, in a limited number of patients, combined treatment with APCC and TXA seemed to be safe, tolerated and relatively effective in management of bleeding episodes and in preventing haemorrhage during surgery in haemophilia patients with inhibitors and in a patient with acquired haemophilia A. Further studies should be performed to confirm these data.Haemophilia 02/2012; 18(4):544-9. DOI:10.1111/j.1365-2516.2012.02748.x · 2.47 Impact Factor
Article: Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial.[Show abstract] [Hide abstract]
ABSTRACT: Conventional anticoagulant treatment for acute deep vein thrombosis (DVT) effectively prevents thrombus extension and recurrence, but does not dissolve the clot, and many patients develop post-thrombotic syndrome (PTS). We aimed to examine whether additional treatment with catheter-directed thrombolysis (CDT) using alteplase reduced development of PTS. Participants in this open-label, randomised controlled trial were recruited from 20 hospitals in the Norwegian southeastern health region. Patients aged 18-75 years with a first-time iliofemoral DVT were included within 21 days from symptom onset. Patients were randomly assigned (1:1) by picking lowest number of sealed envelopes to conventional treatment alone or additional CDT. Randomisation was stratified for involvement of the pelvic veins with blocks of six. We assessed two co-primary outcomes: frequency of PTS as assessed by Villalta score at 24 months, and iliofemoral patency after 6 months. Analyses were by intention to treat. This trial is registered at ClinicalTrials.gov, NCT00251771. 209 patients were randomly assigned to treatment groups (108 control, 101 CDT). At completion of 24 months' follow-up, data for clinical status were available for 189 patients (90%; 99 control, 90 CDT). At 24 months, 37 (41·1%, 95% CI 31·5-51·4) patients allocated additional CDT presented with PTS compared with 55 (55·6%, 95% CI 45·7-65·0) in the control group (p=0·047). The difference in PTS corresponds to an absolute risk reduction of 14·4% (95% CI 0·2-27·9), and the number needed to treat was 7 (95% CI 4-502). Iliofemoral patency after 6 months was reported in 58 patients (65·9%, 95% CI 55·5-75·0) on CDT versus 45 (47·4%, 37·6-57·3) on control (p=0·012). 20 bleeding complications related to CDT included three major and five clinically relevant bleeds. Additional CDT should be considered in patients with a high proximal DVT and low risk of bleeding. South-Eastern Norway Regional Health Authority; Research Council of Norway; University of Oslo; Oslo University Hospital.The Lancet 12/2011; 379(9810):31-8. DOI:10.1016/S0140-6736(11)61753-4 · 45.22 Impact Factor
Article: Recovery, survival, and function of transfused platelets and detection of platelet engraftment after allogeneic stem cell transplantation[Show abstract] [Hide abstract]
ABSTRACT: Recovery and survival of transfused platelets (PLTs) are usually assessed by radioisotope labeling methods for evaluation of transfusion efficacy and new progress in the processing of PLT concentrates. Alternative, nonradioactive methods are warranted. A multicolor flow cytometry method was developed for simultaneous studies of recovery, survival, and function of transfused PLTs. Eight consecutive patients undergoing allogeneic stem cell transplantation (TX) were transfused with apheresis PLTs of nonself human leukocyte antigen (HLA) Class I types, and HLA Class I discrepancy between donor and recipient was used to identify transfused PLTs. Hematologic status and HLA Class I surface expression were analyzed immediately before transfusion, 1 and 6 hours after transfusion, and daily during the subsequent week. PLT activation was assessed by surface expression of CD63, CD62P, or CD42a, before and after stimulation with thrombin receptor agonist peptide. PLT recovery was 43, 41, and 31% for fresh (5-72 hr old) and 30, 27, and 17% for stored (73-148 hr old) PLTs, after 1, 6, and 15 to 28 hours, respectively. Survival of fresh versus stored PLTs were 160 and 105 hours, respectively. Spontaneous PLT activation and residual activation potential were almost equal for fresh and stored PLTs. PLT engraftment was detected between Day 7 and Day 9, which was significantly earlier than first sign of neutrophil engraftment (Days 11-19; p=0.01). Flow cytometry is an attractive alternative to radiolabeling of PLTs for simultaneous studies of survival, recovery, and function of transfused PLTs and early detection of PLT engraftment after allogeneic stem cell TX.Transfusion 11/2011; 52(6):1321-32. DOI:10.1111/j.1537-2995.2011.03442.x · 3.57 Impact Factor
Article: Nordic Haemophilia Council's Practical Guidelines on Diagnosis and Management of von Willebrand Disease[Show abstract] [Hide abstract]
ABSTRACT: Von Willebrand disease (VWD) is the most common inherited bleeding disorder characterized by spontaneous or tissue injury-related, mostly mucocutaneous, bleeding events. VWD affects both males and females and is caused by quantitative or qualitative deficiency of Von Willebrand factor. The diagnostic procedure is complicated because VWD is highly heterogeneous, and differential diagnosis from platelet disorders may be challenging. Moreover, these defects may even coexist, impacting the bleeding phenotype. Mild and moderate VWD can be difficult to distinguish from the normal population, and VWD subtyping may also be problematic. This article summarizes the guidelines of the Nordic Haemophilia Council (NHC), which are intended to serve as a practical tool and provide the standards for diagnosing and treating VWD patients. The complete Nordic Guidelines on VWD are available at the NHC Web site (http://nordhemophilia.org).Seminars in Thrombosis and Hemostasis 07/2011; 37(5):495-502. DOI:10.1055/s-0031-1281034 · 3.69 Impact Factor
Article: rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency[Show abstract] [Hide abstract]
ABSTRACT: The use of recombinant FVIIa (rFVIIa) to control bleed in individuals with FVII deficiency has been proven to be effective. The main problems associated with its use are that it requires frequent bolus injections to counteract its short half-life and high cost. Our study aimed to evaluate whether any advantage could be gained by providing rFVIIa by continuous infusion during surgery with regard to haemostatic efficacy, safety and cost. The prospective study included 10 patients with severe FVII deficiency, who underwent 25 surgical procedures (13 major and 12 minor procedures) and were treated with rFVIIa administered by continuous infusion. Tranexamic acid was given concomitantly every 8 h. Prothrombin time, FVII:C assay and thrombin generation assay were used to monitor the treatment. The mean total dose given was 10 mg during a major surgery and 4.4 mg during a minor surgery for a mean treatment duration of 7.5 and 4.0 days respectively. This corresponds to a reduction of 70-90% in drug usage and medication cost compared with bolus injections. Except for one major perioperative bleeding, excellent haemostasis was achieved in all procedures. One patient developed a transient inhibitory activity. None of these events affected the postoperative course or prolonged the hospital stay. Our study demonstrated that continuous infusion of rFVIIa during surgery is safe, effective and highly cost effective.Haemophilia 06/2011; 17(5):764-70. DOI:10.1111/j.1365-2516.2011.02596.x · 2.47 Impact Factor
Article: Recurrent venous thrombosis, post-thrombotic syndrome and quality of life after catheter-directed thrombolysis in severe proximal deep vein thrombosisJournal of Thrombosis and Haemostasis 06/2011; 9(6):1261-3. DOI:10.1111/j.1538-7836.2011.04298.x · 5.55 Impact Factor
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ABSTRACT: Immune thrombocytopenia (ITP) is caused by immune-mediated platelet destruction and reduced platelet production. The aim of this review article is to provide an updated overview of pathophysiology and new therapeutic modalities in ITP. The article is based on literature identified through a non-systematic search in PubMed and our own clinical experience. ITP is diagnosed in patients with platelet count < 100 × 10(9)/l after excluding other causes of thrombocytopenia. Anti-platelet autoantibodies are important in the platelet destruction mechanism, but other important mechanisms have been identified in recent years. Patients with very low platelet count < 30 × 10(9)/l are particularly susceptible to bleeding complications. The goal of treatment so far has been to increase the platelet count to a level that reduces the risk of serious bleeding. Thrombopoietin receptor agonists are new therapeutic agents that target the thrombopoietin receptor to increase platelet production. These drugs are shown to be effective in treatment of ITP. New knowledge about pathophysiological mechanisms, such as sub-optimal platelet production in ITP, has led to the development of new therapeutic options which focus on stimulation of platelet production.Tidsskrift for den Norske laegeforening 11/2010; 130(21):2120-3. DOI:10.4045/tidsskr.09.1119
Article: Non-genetic risk factors and the development of inhibitors in haemophilia: a comprehensive review and consensus report[Show abstract] [Hide abstract]
ABSTRACT: SUMMARY: The development of inhibitors to the infused factor in patients with haemophilia is a serious clinical problem. Recent evidence suggests that alongside the strong genetic contribution to inhibitor formation, there are a number of non-genetic factors--perceived by the immune system as danger signals--which promote formation of inhibitors. This study provides a comprehensive review of clinical studies relating to these factors and also presents a survey of opinion concerning their importance and clinical influence, conducted among the members of the European Haemophilia Treatment Standardisation Board (EHTSB). Taken together, this information highlights the lack of robust data concerning the influence of several non-genetic risk factors on inhibitor development, and an urgent need for prospective, well-conducted studies that adhere to recommendations made by the European Medicines Agency (EMEA) for studying inhibitors. Based on current literature, the EHTSB formulated consensus recommendations. It is desirable to minimize intensive treatment wherever possible, given the clinical situation. Prophylaxis should be offered to all children, although we still need to determine optimal dosing with respect to inhibitor development, and age for starting treatment. Vaccinations should be given subcutaneously and concomitant factor concentrate infusions avoided. According to the board, there is no evidence in the literature supporting suggestions that the type of concentrate influences inhibitor risk; but all patients should be monitored during their first exposures. Furthermore, there is no evidence to support an association between pregnancy-related issues, breast feeding and treatment-related factors (e.g. route of administration, or use of blood components) and inhibitor development.Haemophilia 09/2010; 16(5):747-66. DOI:10.1111/j.1365-2516.2010.02231.x · 2.47 Impact Factor
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ABSTRACT: Acquired hemophilia is a rare, but often severe, bleeding disorder caused by autoantibodies against a coagulation factor, usually factor VIII (FVIII). The most common clinical presentations are diffuse bruising, soft tissue bleeds, and hematuria. As acquired hemophilia is associated with severe bleeding complications with high mortality, early diagnosis and intervention are crucial. The bypassing agents, recombinant activated factor VII (rFVIIa) and activated prothrombin complex concentrate (aPCC), have been shown to be effective as first-line treatment for bleeds, and treatment should be switched to the other product if the first choice fails. Starting immune therapy to eradicate the autoantibodies should not be postponed. The combination of oral corticosteroids and cyclophosphamide is effective in eradicating the neutralizing autoantibodies, and should probably be the choice for first-line treatment. Rituximab is a promising drug in acquired hemophilia, but should perhaps be limited to second-line treatment.This paper reviews the current literature in management of bleeds and immune therapy to eradicate autoantibodies in patients with acquired hemophilia.
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University of Oslo
Kristiania (historical), Oslo, Norway
- • Department of Haematology
- • Research Institute for Internal Medicine (IIM)
Oslo University Hospital
Kristiania (historical), Oslo County, Norway
- Department of Haematology


text:
" Dudley Mead
Andrew Bloss, Reporter / / News
The council's war against illegal subletters has seen three properties freed up to families.
Croydon Council launched an amnesty which ran throughout February.
It meant tenants illegally subletting their council homes were able to come forward with the promise no further action would be taken against them.
Three properties being illegally sublet in New Addington and Selhurst have now been freed up and four further cases of housing fraud were reported to the council.
The campaign was part of a drive to crack down on tenancy fraud.
Councillor Dudley Mead, the council's cabinet member for housing, said: "We're delighted with the successful outcome of the amnesty.
"But those who think they can get away with illegally subletting their home need to think again."
To report any suspected illegal subletting call the anti-fraud hotline on 0800 328 9270 or visit croydon.gov.uk/housingfraud.
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Croydon Council 'illegal sublet amnesty' frees up three properties
This would not be a problem if councils did their job properly. It's all about organisation and common sense.
We are also one of only a handful of countries in the northern hemisphere where you don't need an ID card - This is why fraud is so easy here!
We are also one of only a handful of countries in the northern hemisphere where you don't need an ID card - This is why fraud is so easy here!

subset: commoncrawl


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Email AddressVerified
Phone Number▒▒▒▒▒▒▒▒▒ 03
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Hey, I'm Marie-Charlotte!
I am a photographer and journalist in her mid-thirties, who loves to explore unknown horizons and find herself among strangers-to-be-friends. Originally French, I lived in New York for ten years, then back in France for a bit, and now in Amsterdam, Netherlands (and... soon to be in Australia!).
Since first grade my teachers have sent reports home with comments such as "Marie loves to participate in class, but she sure is chatty." That hasn't changed much, but I also enjoy peace and quiet, and having my own space (and not impeding on others'). I'm clean and respectful, I usually go to bed earlier than my grandmother, I don't smoke, and I only rarely forget to screw the cap back on to the bottle of olive oil.
I've actually been told by a few reliable sources that I am easy to live with. I'm pretty sure they were lying.
Don't hesitate to ask if you have any other questions or comments!


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EPiServer is looking for top talent!
As we are growing, we are looking to fill several new technical positions. If you are interested in working for a successful global product company, with a flat organizational structure, visit our careers section. Openings include:
Senior Developer for our Digital Marketing Team, Stockholm
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Blog posts
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Major headache when working with EPiServer add-ons and continuous releasePosted: Jul 04 2015This blog is syndicated
EPiServer is currently releasing updates according to the "continuous release" approach. I think this is a nice approach as the customer can take advantage of the new features without having to go through large migration projects. However a problem occurs when you are using official add-ons with EPiServer and the add-ons don't use the same […]
Supporting SVG imagesPosted: Jul 02 2015Views: 222Rating:
Scalable Vector Graphics (SVG) is a very handy image format when working with icons or logos that need to be used in different sizes. Adding support for SVG image files in EPiServer is very easy to do. Adding a vector image content type is done in the same way as adding an image content type. The main difference is obviously the filename...
Planned breaking changes 2015Posted: Jul 02 2015Views: 426Rating:
An update to let you know what breaking changes we are doing in CMS later this year. For many sites the changes will go unnoticed, just another major version number, the latest version of the Alloy templates for example requires no code changes - just recompile and you are done. Breaking Changes Remove hard dependency on Log4Net. This will make ... 3
Why We're Excited About EPiServer Ascend '15Posted: Jul 01 2015This blog is syndicated
Learn why we're excited about the EPiServer Ascend '15 conference and why we think you should be too!
Creating a custom promotion with the new EPiServer Commerce 9 promotion engine (BETA) - Part 2Posted: Jul 01 2015This blog is syndicated
In my previous post I desribed how to programmatically create a custom promotion in EPiServer Commerce 9 beta . The post was developer focussed and showed how we can create custom promotions/discounts in EPiServer 9 than previously possible. In this post I will contrate on the experience of our editors and merchandisers as we want them to see...
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Clarissa Malinda Elizabeth "C.M.E."
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Aug. 17, 1846
Overton County
Tennessee, USA
Aug. 31, 1899
Webb City
Jasper County
Missouri, USA
Encyclopedia of the History of Missouri
January 21, 1866, Mr. Joseph Wheeler Aylor was married to Miss C. M. E. Webb in Grayson County Tx., Clarissa had passed her early childhood in Tennessee, coming from there to Jasper County, Missouri. She was in every way a worthy helpmate to her husband up to the time of her death, in 1899, and their union was a long and happy one. Of four children born to them, two were living in 1900. Their eldest child, Ida Aylor, married Mr. S. Nilson, and they now reside in the Aylor homestead in Webb City. Mrs. Nilson was educated in the public schools of Webb City and at St. Ann's Academy at Osage Mission, Kansas. Mr. & Mrs. Aylor's other surviving child, Ben C. Aylor, married Miss Anna Hardy, and resides at Webb City, where he is interested in the management of his father's affairs and in mining operations of his own. Ben C. Aylor was educated in the public schools of Webb City and at Neosho College under Dr. J. C. Wood, and completed his studies at Washington University of St. Louis.
Joseph W. Aylor, one of the leading capitalists and mine owners of Jasper County, was born September 29, 1839, in Rappahannock County, Virginia, son of Staunton and Malinda (Quaintance) Aylor. Mr. Aylor was reared in Virginia, and enjoyed limited educational advantages, attending school in all but two months and nineteen days. He had a natural genius for business affairs, however, and by dint of industry and the best use of his opportunities acquired much of that kind of knowledge which helps to build up fortunes. When he was twenty years old he went to work for himself, and soon afterward came to Missouri, where he went to work on a farm, receiving twenty dollars per month as wages. He was thus employed until 1861, when he entered the Confederate Army, serving first under Captain Grigsby and later in the battalion commanded by Major Brace, now Judge Brace, of the Missouri Supreme Court. In 1862 he was mustered into the regular service, Confederate States Army, and served thereafter until the close of the war, first under General Martain Green, ithen in General Parsons' brigade of General Price's division. When the war closed, and his regiment was disbanded at Shreveport, Louisiana, he went to Texas and again began work as a farm laborer. In 1866 he returned to Missouri and engaged in farming and stock raising operations on his own account. About 1880 he became interested in various mining enterprises, among these being the Eleventh Hour Mines and the McCorkle Hill Mines, of which he is sole owner. More than two million dollars' worth of lead and zinc ore has been taken from the Eleventh Hour Mine within the past sixteen years, and the McCorkle Hill Mine has produced half a million dollars' worth of ore. These operations have made Mr. Aylor a conspicuous figure among the mine magnates of southwest Missouri, and there are few men in the State whose operations have been so uniformly successful as have his. He has built up a splendid fortune.
Clarissa & Joseph also had two young boys who passed in childhood & are buried at Harmony Grove Cemetery in Jasper
County Mo:
James U Aylor Birth: 1867 Death: 1876
William F Aylor Birth: 1872 Death: 1876
As well Mrs. "Webb" Aylors parents James & Clarissa Webb are buried in Harmony Grove Cemetery in Jasper County Mo.
Mrs Aylors sister Eliza Webb "Jane Chinn" built Jane Chinn Hospital & her cousin John Cornwall Webb, founded Webb City Mo.
This prominent family must have garnered great esteem in the tri-state mining district.
Joseph, Ben, & Ida are buried in Mt Hope Cemetery in Jasper County Mo.
Also buried in Webb City cemetery are her in-laws Staunton & Melinda Aylor.
Family links:
James Crittenden Webb (1805 - 1873)
Clarissa Melinda Elizabeth
Webb (1805 - 1874)
Joseph Wheeler Aylor (1839 - 1917)
James U Aylor (1867 - 1871)
Ida Laura
Nilson (1868 - 1926)
Benjamin C Aylor (1870 - 1941)
William F Aylor (1872 - 1876)
Wiley Warren Webb (1828 - 1907)
Elizabeth Jane
Chinn (1829 - 1913)
Nancy Emaline
Taggard (1832 - 1890)
John C Webb (1834 - 1921)
James Benjamin Webb (1837 - 1862)
Clarissa Malinda Elizabeth
Aylor (1846 - 1899)
Calculated relationship
Webb City Cemetery
Webb City
Jasper County
Missouri, USA
Created by:
Webb City Mo
Record added: Mar 20, 2011
Find A Grave Memorial# 67206578
Added by:
Webb City Mo
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Webb City Mo
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Webb City Mo
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text: Ribosomes are essential for life, generating all of the proteins required for cells to grow. Mutations in some of the proteins that make ribosomes cause disorders characterized by bone marrow failure and anemia early in life, followed by elevated cancer risk in middle age. These disorders are generally called "ribosomopathies."


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Collection The Life of a City: Early Films of New York, 1898-1906
Results 1 - 2 of 2
Refined by:Sites and Collection: The Life of A City: Early Films of New York, 1898 to 1906 Remove Sites and Collection: American Memory Remove Subject: Sidewalks Remove
What happened on Twenty-third Street, New York City /
A street level view from the sidewalk, looking along the length of 23rd Street. Following actuality footage of pedestrians and street traffic, the actors, a man in summer attire and a woman in an ankle-length dress, walk toward the camera. As they cross a grate on the sidewalk they pause, and the escaping air blows the woman's dress to her knees. From a contemporary ...
- Contributor: Thomas A. Edison, Inc - Paper Print Collection (Library of Congress)
- Original Format: Film, Video
- Date: 1901
At the foot of the Flatiron /
This street level view is of the Broadway side of the Flatiron, or Fuller Building, near the narrow north corner. Filmed on a very windy day, pedestrians of various descriptions are seen passing by the camera, clutching hats and skirts against the wind. According to some New York City historians, this corner was known as the windiest corner of the city, and in the ...
- Contributor: Weed, A. E. - American Mutoscope and Biograph Company - Paper Print Collection (Library of Congress)
- Original Format: Film, Video
- Date: 1903


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800 still without power after violent thunderstorms
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800 still without power after violent thunderstorms
Roughly 800 utility customers remained without power Friday afternoon, nearly 24 hours after brief but violent thunderstorms moved through Rockland and Westchester counties. The storms had knocked
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National Aeronautics and Space Administration--Reconsideration
B-408112.3: May 14, 2014
Additional Materials:
- Full Report:
Ralph O. White
(202) 512-8278
(202) 512-4800
(202) 512-8278
Office of Public Affairs
(202) 512-4800
The National Aeronautics and Space Administration (NASA) requests reconsideration of our decision in Wyle Laboratories, Inc., B-408112.2, Dec. 27, 2013, 2014 CPD para. 16, in which we sustained the protest of Wyle Laboratories against NASA's award of a contract to Science Applications International Corporation (SAIC), pursuant to request for proposals (RFP) No. NNJ12399614R, for medical, biomedical, and health services supporting NASA's human spaceflight programs. NASA asserts that our earlier decision was incorrect as a matter of fact and law, and should now be reversed.
We deny the request for reconsideration.
Jun 30, 2015
- Precise Management, LLC--ReconsiderationB-410912.2
Jun 29, 2015
- Bode Aviation, Inc.B-411265
- Decisive Analytics CorporationB-410950.2,B-410950.3
Jun 26, 2015
- SageCare, Inc.B-411260
- Computer World Services Corporation; CompQSoftB-411216,B-411216.3,B-411216.4,B-411216.5
- WKF Friedman EnterprisesB-411208
Jun 25, 2015
- K-MAR Industries, Inc.B-411262,B-411262.2
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Wavves Unveil Album Details, New Song, Announce Tour With FIDLAR
The wait is over. Last night, Wavves threw the curtains back and unveiled all the details surrounding their eagerly-anticipated Mom+Pop debut, Afraid of Heights. That's the cover art up above. Heights is available for pre-order — in multiple configurations including pins, t-shirts, and Nathan's long awaited Negative Dad comic — right here.
In other news, Wavves also announced a run of March and April dates with our very own FIDLAR. When we say that this tour is going to be insane, believe us. The bands will be playing in small rooms throughout the US. How small? We're talking a pair of NYC gigs at Shea Stadium and Glasslands. Prepare to get kicked in the face and like it. Tickets go on sale Friday, February 1st. Get them quick.
Stream the album's lead single, "Demon To Lean On," here, and check out the tracklist and full run of dates below the fold.


text:
Allied Materials & Equipment Company, Inc.
B-293231: Feb 5, 2004
Additional Materials:
- Full Report:
Ralph O. White
(202) 512-8278
(202) 512-4800
(202) 512-8278
Office of Public Affairs
(202) 512-4800
Allied Materials & Equipment Company, Inc. protests the award of a contract by the Defense Logistics Agency (DLA), Defense Supply Center to ILC Dover, Inc., under request for proposals (RFP) No. SP0560-03-R-0186, for chemical-biological filter elements. Allied alleges that the agency's failure to post the solicitation to FedBizOpps, the government-wide point of entry (GPE), as required by the Federal Acquisition Regulation (FAR), improperly denied it the opportunity to compete for the contract.
We deny the protest.
Jun 30, 2015
- Precise Management, LLC--ReconsiderationB-410912.2
Jun 29, 2015
- Bode Aviation, Inc.B-411265
- Decisive Analytics CorporationB-410950.2,B-410950.3
Jun 26, 2015
- SageCare, Inc.B-411260
- Computer World Services Corporation; CompQSoftB-411216,B-411216.3,B-411216.4,B-411216.5
- WKF Friedman EnterprisesB-411208
Jun 25, 2015
- K-MAR Industries, Inc.B-411262,B-411262.2
Looking for more? Browse all our products here


text:
$7.99The fight for Apollo was a bloodbath, the King is dead, and civil war grips the Empire, forcing humans everywhere to shed human blood or flee in terror. Planets fall, fleets are destroyed, and now the throne itself hangs in the balance. Caerwyn and Kalila wage open war to claim it, knowing its fate will determine the future of humanity—if any future can still be hoped for.Watching the chaos from a
The Phoenix Conspiracy (Book #4)A fearful Empire anticipates King Akira's next move: will he abandon them to the corrupt hands of Caerwyn Martel or doom them to bloody civil war, leaving them defenseless against an imminent alien invasion?Just beyond human space, the crows are circling. Across the DMZ, the Rotham Republic prepares its war fleets with hungry eyes fixed on the weakened Empire. Spurred on to war by the pervasive
The Phoenix Conspiracy (Book #3)A storm is brewing. Eager war fleets patrol the edges of human space, waiting.The leaders of the Phoenix Conspiracy are poised to usher in The Hour of Ascension. And it is up to Calvin to expose the conspiracy before the Empire collapses in a firestorm of civil war.Deadly isotome weapons remain at large, forces across every border are arming for war, and now even the monarchy itself is threatened
$7.99The world might have ended five years ago. For the second time. Had Caythis not raced to Andar City to stop the one man who could destroy everything. Antares. The man with the power of a god. The man whose fiery inferno reduced Andar to ashes. The man who'd already annihilated a fourth of the human race. Caythis fought him on the cliffs of Andar. Fought to save the world. They both vanished. Their
The Phoenix Conspiracy (Book #2)As the most serious threat ever facing the galaxy now looms over them—weapons able to destroy stars—Calvin and his enterprising crew continue their mission to expose and eliminate the dark conspiracy that has taken root inside the Empire. Now a fugitive on the run, Calvin has no choice but to work alongside Raidan's mysterious Organization. And accept help from the unlikeliest band of fair-weather
The Phoenix Conspiracy (Book #1)On the surface, the galaxy seems peaceful. Humankind prospers from the Capital World to the far reaches of The Corridor. But to those who can see the signs, it's clear something is wrong. Long, dark fingers are pulling strings inside the military, making clandestine deals with enemy states, and fulfilling some dark design.Calvin is an intelligence agent working for the Imperial government. He's
$0.99Jason is a member of Nexus, a secret organization with a singular purpose: eliminate crime and protect the innocent. As a Nexus operative, he is a Mind Bender and can implant thoughts into the minds of others. It is a dangerous and powerful gift that sometimes has lethal consequences, and forces even the best Mind Bender to see the world through a lens of doubt and suspicion—constantly wondering
The Cyber Chronicles IV: Cyborg
The Cyber Chronicles (Book #4)For three long years, Tassin has tried to find a way to travel to the stars and free Sabre. Her hunt for the sword the Core lives in has proven futile, until one day a serving boy finds a key, and she discovers where Sabre hid the sword. She persuades the malevolent weapon to take her to Sabre, and arrives on the planet Ferrinon Four. Lost in a modern city, Tassin goes to a private detective who,
Demon Lord VIII: When Angels FallThe archangel Majelin has been imprisoned and tortured in the underworld of Sherinias' domain for five centuries. Eventually, his light will die and he will fall to the darkness. Whispers of a tar'merin travelling with Kayos have reached Airedene, the Sacred City of Angels, giving Sarmalin hope that her husband might be saved, and she goes to plead with the Demon Lord.The archangel is in a chamber
Peace Army, Book 2 of the Peace Warrior TrilogyPeace ArmyIt's been six years since Grant Justice was brought back to life to help the Peaceful citizens of Earth defeat the Minith.Life should be good. The Minith are gone. Grant now has a loving wife and a remarkable son. He is a hero to the society that once shunned him.But Grant hasn't been taking life easy. He's been recruiting fighters away from Peace. He's been cobbling together an army
$2.99A Grey God's impregnable shield sphere is his last defence, but a domain Key might unravel it and force him to flee into the unknown, for to Move in the God Realm is to be lost… Bound and powerless, the Demon Lord is doomed unless a light god comes to his aid, but he can no longer wield the shadows. Kayos waits for his dark son to free him, and his time is running out…
$4.99Starforce Ganymede is the first book in the epic new science fiction adventure series that chronicles the creation of the first interplanetary Starforce to battle humanity's descent into crime and corruption.One man is chosen to spearhead the new paramilitary organisation in a desperate attempt to return law and order. This elite team of officers is honed into a force ready to take on the gangs in


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John Mulaney Breaks Down Why Robert Durst Deserves an Emmy on 'The ...
The Meltdown with Jonah and Kumail returned to Comedy Central last night, and among the standup guests was John Mulaney, who makes a pretty solid case for The Jinx's Robert Durst as a very deserving Emmy contender. As Mulaney explains to ...
LA Weekly
Jeff Garlin Honors...Special Guest John Mulaney
LA Weekly
Tonight, Garlin sits down with John Mulaney for his new conversation series, which he kicked off in May with Bill Hader. Mulaney fans disappointed over the recent cancellation of his FOX sitcom have been able to keep up with the former Saturday Night ...
Huffington Post (satire)
Bill Hader Recalls The Real-Life Inspiration For His Iconic 'SNL' Character Stefon
Huffington Post (satire)
The actor, who stars in Pixar's latest film "Inside Out," said that John Mulaney, the writer behind Stefon, got a bizarre email that provided the foundation for Stefon's schtick. "He got an email from some guy saying, 'You have to come to this club ...
and more »
Reginald D Hunter, Nick Kroll, John Mulaney and more announced for Vodafone ...
Get those ribs primed for a tickling, the Vodafone Comedy Festival is back again this year and will once again see a wealth of the best homegrown and international talent taking to five different stages in the Iveagh Gardens over four days this July.
and more »
Irish Mirror
Vodafone Comedy Festival line up: Reginald D Hunter, Nick Kroll, John Mulaney ...
Irish Mirror
International talent performing at the festival includes US comedians Reginald D Hunter, Nick Kroll, John Mulaney, Michelle Wolf, Aparna Nancherla, Joe List, Seaton Smith and the unique talents of The Pajama Men. Canadians Tom Stade and Glenn Wool ...
and more »
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text:
When the user (client) tries to get into the application by typing the URL, i need to get that machine's windows logged in username.
I have tried with
System.getProperty("user.name") but when I access the application from some other machine (client) then this still shows username of logged in user on server. I want this is to be changed according to the client machine username every time.
And also I have tried with some JavaScript code, it only works on IE but we are using Firefox.
Kindly suggest the possible ways to work with all kind of browsers.
Application Details:
View: Struts
Application Framework: Spring 3.1.1
Application Server: jboss-6.1.0.Final
Server OS: CentOS 5


text:
Panthers wide receiver Steve Smith told Mike and Mike in the Morning that he ended the career of former Redskins cornerback Fred Smoot.
"A guy that I think, and I take pride in, I destroyed his career, is Fred Smoot," Smith said.
"Coming out of Mississippi, he was considered a really good corner back, and I thought he was," Smith said. "And then after coming in Bank of America Stadium, things just went downhill from there."
Smoot made an appearance on 106.7 The Fan's Washington Game Day Uncensored on Sunday morning and fired back at Smith.
"He's a Grade A receiver. I was a Grade A corner and here go the thing about it. Grade A's cannot hurt Grade A's," Smoot said
"The only person that could have hurt my career is a Grade F," he said. "That means a guy with no name on the back of his jersey come in and beat me to death, he can ruin my career. But for me to go out and get beat by a Jerry Rice, is to me to give up yards to Jerry Rice. And my coach is gonna look me in the face and say 'You did a good job. Nobody can stop him.' Alright?
"Well, for me to go get beat by Megatron is for me to go get beat by Megatron, alright. So I don't get him on that. And the thing about Steve, me and him hate each other. If I run into Steve Smith in a Giant right now, I'll fight Steve Smith in a Giant right now. I don't give a — I don't care."
"We don't like each other," he tacked on. "We've never liked each other. We came out of school together. We've ran into each other and we just don't like each other."
Smoot was then asked if he's run into Smith at any NFL events.
"I don't," Smoot said. "And I think he's a bully. Actually, I think he's a weak bully at that. And I'll be honest with that. I don't care about saying that. He's Steve Incognito to me. I call him Steve 'Pinocchio' Smith, cause he's a liar. He went on national t.v. and lied. He's a liar.
"And I like to keep it real and I like to be honest. This guy wants to sit here and say he ruined my career, and I played you two to three times after that, and you did nothing. I played you actually ten times before that, as a Redskin, and you gonna talk about the one time that you actually got me.
"I can say this about Steve Smith, and I can say this, my worst day in the NFL, he had a part in. He's the guy that beat me. But I don't say he beat me. [Jake] Delhomme threw great passes all day long, and beat me. I had Ted Cottrell as a defensive coordinator call Cover 3 all day, and got me beat. So it's fine, I don't make excuses. He beat me. But no, you didn't ruin my career, and yes, I'm happy and I'm still smiling, and I'm good, and I'm fine Steve Smith. So don't worry about it Steve Incognito. You're so soft. Hey, I'm gonna tell you what he did.
Smoot ritereated that Smith is "soft."
"He's soft!" Smoot declared. "I've seen him jump on Ken Lucas. Ken Lucas, anybody will tell you about Ken Lucas."
Smoot explained why Smith is always getting into it with opposing players during games.
"Only reason he wants to fight people during a game, is because we got helmets on, we got shoulder pads on, and somebody's gonna rush and break it up. Referee, teammate, it doesn't matter," Smoot said.
"Put it like this, if I'm in a dark alley and I'm gonna fight a couple guys, I don't want Steve Smith with me," he added. "He's nothing but a talker, he's soft. Come to Mississippi with that. That's what you do. You come to Mississippi and we'll teach you a couple lessons out there. We'll show you how to be tough. He's not tough. He wants to fight everybody in front of everybody, when he knows everybody's gonna break the fight up, do this, do that.
"They're not tuning in for a UFC fight," Smoot said of football fans. "They're tuning in for NFL football. And what he wants to do is show out in front of people, try to fight people while you got helmets on, while you got this on, you want to do this. You soft, man. Let's be honest. I like to be honest and I like to be a good person. He's soft. I don't really care about it."


text: کس چاق کس دادن به اسب Its pretty pathetic when the first fight scene with Goku and the `bullies` is the best and he never threw even threw a punch. کس چاق hopefully its getting better. کس سفید When does instinct and experience pay off? Another big negative to the series is the reliance on the green computer goggles. کس چاق Dragonball is a hot cult in Asia and it hits the western market because of the stylistic action and fight sequences. Where is the human element, the character? i don`t know who has made the sigma six but its awful what happened to the other characters what happened to general hawk ltd. Vegeta, both the prince, his king father and the Saiyan home planet originally named Planet Plant, means Vegetable; Raditz is not `radish`, and Kakkorotto is not `carrot`. کس دادن به اسب For one of the most action packed animes around they sure did the opposite with the movie. کس سفید These goggles keep the Sigma Six team connected to Hi-Tech and the various Sat Links, but it also turns the GI Joe team into nothing more than drones controlled by the mainframe. کس وکون and this shall also be asked that what is also happening to the new generation buy watching such things? کس سفید The villain Freeza originally Friezer comes obvious, and his brother Cooler and their father King Cold.


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How is the Sheraton Hotel at the Tokyo Bay?
How is Cirque Zed?
Best place to eat dinner at in TDR version of DTD?
How early should I get to the entrance?
Which rides have a single rider line?
Best restaurants at TDL and TDS, lunch and dinner?
How does the popcorn bucket. Basically buy the souvenier and refill with any flavor I want to try? Side note can I grab and eat or drink while I walk? I know the Japanese don't do that, but i thought it might be different there.
Best location to watch shows or parades?
Basic entry plan
at Tokyo Disneyland i will get to park an hour early. Get a FP for Monsters Inc, ride Space Mountain, get FP for Pooh, use FP and ride Monsters Inc, then ride something before using FP for Pooh
at Tokyo Disney Seas i will get to the park an hour early. Get a FP for Journey, ride Journey, then ride 20k, then use FP to ride Journey.
Planned for Tokyo in general:
Mt Fuji Tour, bus, cruise, sky ride, and then bullet train back.
Tokyo Depot and go to Joyopolis and Muscle Park
Tokyo Dome baseball game, La Qua, and Tokyo Dome Amusement park
Any other recommendations, answers, or comments?


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I am looking to create an SEO friendly URL after a filter has been submitted in an html form.
After playing around for a while I have found a way, however I was wondering what otehr people think of it as I'm new to development.
I have added some rewrite rules in the .htaccess file to make the urls more friendly. Examples below:
Original URL: site-nane/list.php?brand=brand1&min-price=0&max-price=2000
URL after rewrite: site-name/section/brand1/0-200
Currently I have the form that submits the information to a separate php page which collects the variables and creates a new url from it which then redirects with a 301. Example of php below:
$min = $_GET['min-price'];
$max = $_GET['max-price'];
$brand = $_GET['brand'] ;
header ('HTTP/1.1 301 Moved Permanently');
header('Location: http://site-name/section/' . $brand . '/'. $min.'-'.$max );
As you can see it collects the info and takes you back to the page and declares the previous page has permanently moved.
Although this maybe quite primitive, will this still be ok to use without causing too much trouble?
Will google hate me for creating so many 301's
Just noticed the code header("Location: /foo.php",TRUE,301); would it be best to use this or no difference?


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Michigan State Beats Virginia 61-59
Branden Dawson had 24 points and 10 rebounds as Michigan State beat top-seeded Virginia 61-59 to advance to East Regional final.
Arizona Holds Off San Diego State 70-64
Arizona rallied to beat San Diego State 70-64 Thursday night and advance to the final eight of the NCAA tournament.
Haith: Tigers Pleased to Play in NIT
For the first time in six years, the Missouri Tigers are left out of the NCAA tournament.
10 Sports Pilgrimages Every Guy Should Make Once In His Life
Which sports events are worth planning a vacation around? Check out these ten sports happenings every guy should make a trip for.
Billikens Flash Past Fordham
Dwayne Evans scores 21 and has 10 rebounds to lead the way as SLU moves to 17-2.
Ackerman: How Bob Knight Comforted Me After Losing My Dad
As Father's Day approaches, KMOX Sports Director Tom Ackerman reflects on how Indiana basketball coach Bob Knight helped him through a difficult time in his life–losing his father.
Charlie Brennan: Phil Jackson
Jackson, also known as the "Zen Master", joined Charlie to discuss his new book, Eleven Rings: The Soul of Success.
Cleveland Cavaliers Claim Top Draft Pick
The Cleveland Cavaliers claimed the No. 1 overall pick at the 2013 NBA Draft Lottery on Tuesday night.
Sports Verdict: Who's The Bigger X-Factor? Kevin Durant Vs. Carmelo Anthony
With the game, series, or season on the line, would you rather have Carmelo Anthony or Kevin Durant on your squad?
Hawks Lose to Raptors 113-96, Tied With Chicago For #5 Seed
DeMar DeRozan scored 30 points, Rudy Gay added 22 and the Toronto Raptors ran all over playoff-bound Atlanta, routing the Hawks 113-96 Tuesday night.


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Jytte Klausen writes on Charlie Hebdo shooting in Foreign Affairs and Time Magazine
Jill Greenlee publishes in Politics, Groups, and Identities
Interview with Jytte Klausen on Research and Open Access
Supreme Court case could set standard for Internet threats
Bernard Yack to give keynote address at nationalism conference in Hong Kong
Yasser Kureshi (Ph.D. candidate) publishes in volume on civil wars in South Asia
Jill Greenlee interviewed on WGBH News
Jytte Klausen interviewed on PBS Newshour and Global News
Midterm elections: motherhood, age and gender's influence on political behavior
Jill Greenlee discusses the Massachusetts gubernatorial election with the Boston Globe
Jytte Klausen publishes in Foreign Affairs
Eva Bellin publishes in Middle East Brief
Crown Center panel covers major topics in Middle East
"Global Terrorism" course to host two special guest speakers
Shai Feldman publishes in Middle East Brief
Shai Feldman publishes in The National Interest
Jill Greenlee discusses her new book with MSNBC's Melissa Harris-Perry
Shai Feldman publishes in World Politics Review
Danielle Higgins (MA '14) publishes on Huffington Post
Jill Greenlee publishes The Political Consequences of Motherhood
Shai Feldman publishes in The National Interest
Ehud Eiran (Ph.D. '10) publishes on The Monkey Cage
Matthew Isaacs (Ph.D. candidate) publishes on Political Violence at a Glance
Karim Elkady (Ph.D. candidate) receives Truman Library research grant
Shai Feldman publishes in The National Interest
Eva Bellin's research on Arab Spring cited in The Boston Globe
Adam Smith (Ph.D. candidate) receives Outstanding Teaching Fellow award
Danielle Gewurz (B.A. '11) to pursue MS in Public Policy at Carnegie Mellon
Hailey Magee (B.A. '15) accepted to NEW Leadership New England summer program
Funding Opportunities from the Research Circle on Democracy and Cultural Pluralism
Shai Feldman publishes in Middle East Brief
Jeffrey G. Karam (Ph.D. candidate) accepted to Summer Institute at Elliott School of International Affairs
Experts say Ukraine must bond with West
Seth Werfel (B.A. '10) publishes on The Monkey Cage
Jill Greenlee publishes in Journal of Political Science Education
New Brandeis Textbook Offers Even-Handed Look at Israeli-Palestinian Conflict
Sarah Feuer (Ph.D. candidate) wins ASMEA Best Student Paper Award
Professors ponder how JFK's presidency could have turned out
Justice Brandeis Semester expands its offerings
Shai Feldman co-authors Crown Center book
Six new Politics courses for Spring 2014
Jill Greenlee's research on race cited in Washington Post
Bernard Yack's most recent book to be subject of symposium at LSE
Jill Greenlee participates in Gender and Political Psychology Research Workshop
Eva Bellin publishes in Middle East Brief
Eugene B. Kogan (PhD '13) accepts post-doctoral position at Harvard University
Summer institute takes Israel studies around the globe
Steven Burg publishes in Nationalism and Ethnic Politics
New Board of Trustees chair Perry Traquina '78 believes in giving back by investing in the next generation
Kerry Chase Awarded Provost's Innovations in Research Award
Kerry Chase Awarded Provost's Innovations in Teaching Grant
Ryan LaRochelle wins prestigious Robert C. Wood Prize
Melissa Schwartzberg, New York University, gives public lecture, "Supermajority Rule and Democracy."
Jill Greenlee participates in Gender and Political Psychology Research Workshop
Oct. 08, 2013
This summer, Professor Jill S. Greenlee was selected to participate in the Gender and Political Psychology Research Workshop at Northern Illinois University.
The overarching purpose of this workshop was to form a network of political scientists and psychologists who are employing new research approaches and techniques to the study of gender with emphasis on intersectionality.
Professor Greenlee's research focuses on political socialization, gender and politics, and racial attitudes. Her forthcoming book, The Political Consequences of Motherhood (University of Michigan Press) combines a historical overview of how motherhood has been used in the American political landscape over time with individual-level analysis exploring how and when motherhood shapes the thoughts and preferences of women. In addition to research on gender, Professor Greenlee has investigated questions related to racial attitudes and generational change. She has published work in journals such as Political Psychology, Politics and Gender, and P.S. Political Science and Politics. Professor Greenlee teaches courses in American Politics, Women and Politics, Political Behavior, and Research Methods.


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Reduction of capital without court approval now possible for Jersey companies weblink
A summary of the new out-of-court procedures for reductions of capital.
Civil liability for breaches of the codes of practice and AML/CFT Handbook – an update weblink
The Jersey FSC now has the power to impose civil financial penalties for significant and material contraventions of the codes.
Does the intention required for a Quistclose trust differ onshore to offshore? weblink
Recent English case law has served to emphasise the requisite levels of intention needed on the part of the transferor for the creation of a Quistclose trust or any other sort of analogous resulting trust.
A guide to Jersey property unit trusts weblink
Jersey property unit trusts are frequently used to acquire and hold interests in UK commercial real estate due to the ease with which they can be established and the fiscal advantages they can potentially bring.
Basel III and the demise of cash as king weblink
Expect to see investors ask more frequently about a fund's cash management solution.
Cayman: mutual funds and understanding form MF1 weblink
Any changes that materially affect the information filed in the offering document or MF1 be filed with CIMA within 21 days.
Cayman Islands Court of Appeal rules on rights of non-registered investors to enforce shareholder rights weblink
The Cayman Islands Court of Appeal (CA) considered whether a beneficial owner of shares in a fund could seek to prove in the liquidation of that fund in respect of rights granted under a side letter.
Weavering litigation – Cayman hedge fund directors' duties and indemnity/exculpation clauses back in the spotlight weblink
The Cayman Islands Court of Appeal has issued its much-anticipated decision in Weavering Macro Fixed Income Fund Limited (In liquidation) vs Stefan Peterson and Hans Ekstrom...
BVI funds products for start-up investment managers weblink
The BVI has published the Securities and Investment Business (Incubator and Approved Funds) Regulation. These Regulations introduce two new funds products into the BVI's funds offering,...
BVI launches two funds products weblink
The British Virgin Islands Financial Services Commission has introduced two new funds products, the 'Incubator Fund' and the 'Approved Fund'.
Luxembourg: anti-money laundering – find the beneficial owner weblink
Several mechanisms and arrangements are available for someone who wants to conceal his involvement in a transaction.
Audit extensions in Cayman weblink
In what circumstances will the Cayman Islands Monetary Authority grant a registered mutual fund an extension of time to file its annual statements?
Transparency of beneficial ownership in Guernsey weblink
Guernsey has commenced consultation on the introduction of a central register of beneficial ownership.
Jersey trusts and divorce – submission and exclusion weblink
Two judgments have provided some insight into the exercise of the Royal Court's supervisory jurisdiction over Jersey trusts.
Jersey and the capital markets – AIMing for the top weblink
What makes Jersey so attractive to companies? (And there's more to it than tax.)...
Funds update: AIFMD implementation under fire; European agreement on beneficial ownership registers; and more weblink
Also: new Jersey accounts documentation and recent case law.
Jersey investment funds – the regulatory options weblink
One of the key features of Jersey's funds industry is the range of structures and regulatory approaches that can be used.
Guernsey's collective investment rules – a welcome change weblink
Registered collective investment schemes may be offered direct to the public in Guernsey for the first time.
Transfer of shares of Cayman companies in liquidation weblink
In response to a growing number of cases where clients want to sell or transfer shares in a Cayman Island company which is in liquidation, this report clarifies the rules.
Family offices defy generalisation weblink
Family offices are highly differentiated and need advisers who can understand the variety of needs inherent in looking after wealthy and entrepreneurial families.
Cayman Islands FATCA portal for TIA notification now open weblink
The Cayman Islands Department for International Tax Cooperation has launched its Automatic Exchange of Information portal and released an accompanying user guide.
Representation of Z Trusts – an equitable remedy weblink
A case concerns whether or not there is a form of equitable remedy which would justify an earlier trustee who had disposed of assets.
Increased obligations when charging for improvements could prove a headache for landlords weblink
A recent decision of the UK Upper Tribunal (Lands Chamber) could influence Jersey's Royal Court in interpreting the 'reasonableness' of service charge items.
Jersey: civil liability for breaches of the codes – an update weblink
The Jersey Financial Services Commission consultation paper indicates that there will be three levels of penalty for material contraventions of the Codes of Practice.
Portfolio insurance companies in the Cayman Islands weblink
The Cayman Islands legislature recently enacted The Insurance (Portfolio Insurance Companies) Regulations, 2015 and related sections of The Insurance (Amendment) Law, 2013.
Jersey legislation overview weblink
There have been a number of significant legislative developments in Jersey since November 2012, as reflected in the length of this briefing.
No solvency test for payment of redemptions from Cayman funds? weblink
Decisions over the past 12 months will provide considerable comfort to those concerned about exposure to clawback action.
Insolvency proceedings and foreign companies weblink
The High Court of England and Wales may refuse to exercise its discretion to wind up companies incorporated abroad where there would be little likelihood of the petitioners deriving benefit from the winding-up.
Acquiring commercial property in the Channel Islands: a brief comparison with England weblink
A brief synopsis of the main differences between Jersey, Guernsey and English Law in relation to property transactions.
Luxembourg new tax measures 2015 weblink
On 19 December 2014 the Luxembourg Parliament enacted Bill no. 6720 and Bill no. 6722 introducing new Luxembourg tax measures applicable for corporations and individuals as of 2015.
Luxembourg joint ventures weblink
Joint ventures are not a particular term of art under Luxembourg law.
The new statutory test for mistake under the microscope weblink
These two cases are helpful in terms of how the court sees the inter-relationship between the new article 47 test for mistake and the pre-existing provision of the TJL at article 11.
Changes to the ability to restore a company to the register in Guernsey weblink
On 24 November 2014 Guernsey's Legislation Select Committee passed the Companies (Guernsey) Law, 2008 (Amendment) Ordinance, 2014 with immediateeffect.
The Security Interests (Jersey) Law 2012: changes to Jersey's security regime weblink
This article summarises the main changes under the new law (particularly advantages for lenders) and the transitional provisions which apply to old law security.
The new Charities Law — a bright new dawn weblink
This briefing is primarily intended to help service providers and charities understand how the law might affect them, and how they should respond.
Guernsey Companies Law: migrations into and out of Guernsey weblink
This memorandum has been prepared for the assistance of our clients in connection with the provisions relevant to migration of companies into and out of Guernsey under the Companies (Guernsey) Law, 2008 (as amended) (the Companies Law).
Special-purpose acquisition companies weblink
This client briefing gives a brief overview of the structure and benefits of using special-purpose acquisition companies.
Channel Island Securities Exchange Authority: listing of securities of investment funds weblink
The CISX is licensed to operate as an investment exchange under the Protection of Investors (Bailiwick of Guernsey) Law 1997.
Guernsey's insolvency regime set to reform weblink
On 24 October 2014, the Commerce & Employment department published its consultation paper on various options for reforming Guernsey's insolvency regime.
Enhancements to the Companies (Jersey) Law 1991 weblink
The Companies (Amendment No. 11) (Jersey) Law 2014 came into force on 1 August 2014. The law made a number of changes to the Companies (Jersey) Law 1991.
Luxembourg-Cayman private equity structures weblink
This briefing summarises some key characteristics of such structures.
Enforcement of pre-2014 Jersey security agreements weblink
The Security Interests (Jersey) Law 2012 came into force on 2 January 2014, introducing a new regime for creating security over intangible movables under Jersey law.
Insolvency procedures in respect of Jersey companies weblink
Lenders, borrowers and other counterparties are looking more closely at the impact of possible insolvency proceedings.
Channel Islands Securities Exchange Authority: continuing obligations chapter 8 debt securities weblink
This briefing sets out certain of the continuing obligations that an issuer is required to observe once any of its securities have been admitted to listing.
Luxembourg corporate: foreign direct investment — structuring the equity weblink
This briefing summarises some of the areas frequently encountered in relation to equity structuring choices.
Luxembourg — Cayman private equity structures weblink
This briefing summarises some key characteristics of such structures.
Issues for trustees of Guernsey trusts when foreign couples divorce weblink
This briefing discusses some of the issues to be considered by trustees of Guernsey trusts and their advisers when foreign couples connected with the trust divorce.
FATCA update — now is the time to review your position weblink
The US Foreign Account Tax Compliance Act (FATCA) Regulations came into effect on 1 July 2014.
Migration of companies into and out of Jersey weblink
A company registered in a foreign jurisdiction can migrate from its home jurisdiction to Jersey provided the laws of the foreign jurisdiction allow it to do so.
Investec and Ors v Glenalla and Ors — Court of Appeal judgment 27 June 2014 weblink
This judgment in the Court of Appeal considered an appeal on one part of the judgment of Lieutenant Bailiff Chadwick (the Judge) of December 2013.
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Lucas' Papaw Ointment makes a comeback as beauty's latest miracle product
This 100-year-old product is fast becoming a favorite of beauty insiders and celebrities.
Beauty buzz from the editors of StyleBakery.com, including product reviews, beauty how-tos, celebrity style and more.
This 100-year-old product is fast becoming a favorite of beauty insiders and celebrities.
Six products are all you need for a gorgeous, natural, summer-proof look that takes less than four minutes from start to finish. Best of all? No makeup brushes needed, so it's perfect for a weekend getaway.
This drugstore find features one of the thinnest, most accurate brushes on the market, allowing you to create a smooth, precise line in seconds.
The oceans have long been revered for their restorative properties, both of body and soul.
For years, hair stylists have been trying to convince women to skip their daily shampoo and go a few days without washing to keep hair healthier. These products make skipping the shampoo easier than ever.
The easiest way to get beachy waves in minutes — on any hair texture.
Basic mani/pedis just won't do this summer, not with all the gorgeous colors available. Case in point: this adorable seaside beach house box from Ciate.
We all know how important it is to use sunscreen every day, especially on the face, and the best way to ensure your daily coverage is to choose a daily moisturizer with SPF 15 or higher. But not all SPF moisturizers are created equal.
Actress Shailene Woodley is well known for her dedication to eco-living and in this month's InStyle, she shares recipes for her favorite at-home eco-beauty fixes.
Headed away for the weekend? Lighten your load with 10 on-the-go beauty must-haves.


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Conferences at Lied Lodge
Amazing events start with an amazing location.
You've lined up great speakers. You've outlined a power-packed agenda. Now let us help you turn your conference into one that will have attendees asking about next year's event.
- 144 guest rooms
- 14,000 square feet of adjustable space
- Designated Conference Planning Managers
- Complete meeting packages
- On-site audio-visual equipment and support
- Airport shuttle service from Omaha Eppley Airfield
Add to this 260 beautiful wooded acres, miles of hiking trails, world-class golf, excellent food, and stunning architecture, and you'll see why meeting planners all across the country choose Lied Lodge.
phone Call 402-873-8705
email Email email@example.com
More testimonials
The audio/visual staff was so prompt it almost seemed magical! We pushed a button, and a staff person was there, taking care of whatever we needed. Good job!Heartland Baptist District


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A look at the private life of Hermann Goring, Hitler's devoted follower and second-in-command.
The wonderful and bizarre story of the Mount Rushmore National Memorial's creation is detailed. Watch Preview.
WOSU TV features award-winning children's shows, public affairs, science, and nature programs from PBS and award-winning locally produced programming.
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