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Full name Simon James Arnold Taufel
Born January 21, 1971, St Leonards, Sydney, New South Wales
Current age 44 years 163 days
Other Umpire
|Test debut
|Australia v West Indies at Melbourne, Dec 26-29, 2000 scorecard
|Last Test
|England v South Africa at Lord's, Aug 16-20, 2012 scorecard
|Test matches
|Test statistics
|ODI debut
|Australia v Sri Lanka at Sydney, Jan 13, 1999 scorecard
|Last ODI
|England v South Africa at Lord's, Sep 2, 2012 scorecard
|ODI matches
|ODI statistics
|T20I debut
|Kenya v New Zealand at Durban, Sep 12, 2007 scorecard
|Last T20I
|Sri Lanka v West Indies at Colombo (RPS), Oct 7, 2012 scorecard
|T20I matches
|T20I statistics
In a field where middle-age has been the norm, it was a supreme vote of confidence that Simon Taufel was asked to umpire his first Test at 29. Over the next decade, he repaid that faith by being named the ICC's Umpire of the Year every year from 2004 to 2008. His rise was so rapid that he quickly became one of the most experienced officials on the Elite Panel, despite being by far its youngest member. But that heavy workload also took its toll on Taufel, who in 2008 said he wanted to spend more time with his wife and children and was taking his cricket future "year by year". Respected by the players for his consistently accurate decision-making, Taufel stood in three World Cups and earned the chance to officiate in the 2011 final, when Australia failed to reach the decider for the first time in five World Cups. A calm and confident official who worked hard on his fitness, Taufel developed while on the international scene. When he first arrived he hunched over as the bowler let fly, lowering his eyeline like umpires of old. That habit disappeared as Taufel's self-assurance increased, although his concentration did not wane.
His early entry into the umpiring ranks came after his playing career stalled due to a back injury. A promising fast bowler, in 1988-89 Taufel took the new ball in a New South Wales schoolboys' representative team captained by Michael Slater with Adam Gilchrist behind the stumps. He played for the North Sydney and Mosman clubs before first officiating in fifth-grade games at 20. Taufel was 27 when he stood in his first ODI, a match where his old team-mate Gilchrist scored a century, and 29 when his Test debut came in the 2000 Boxing Day match. Occasional internationals followed while he worked as the operations manager in a printing firm, and in 2003 he was added to the ICC's Elite Panel, where he and the New Zealander Billy Bowden were viewed as the next generation of umpires. In 2012, Taufel retired at the age of 41, deciding to spend more time at home with his family. He also took up the newly-created role of umpire performance and training manager with the ICC.
Brydon Coverdale
ICC Umpire of the Year 2004, 2005, 2006, 2007, 2008
A squad without pace, keepers, or future planning
Five questions for the selectors who picked the second-string squad for the tour of Zimbabwe
Highest totals without a century, and dream ODI debuts
Also: the most team changes made by a country in successive one-day internationals, and highest individual Test scores in the second innings
Johnson back to intimidate with word and deed
At the age of 33, Johnson does not expect to be back for another Ashes campaign and, since being forced to miss last year's World Twenty20 with a toe injury, he has played every game as if it is his last
'If you play your game, you are fearless' - Vijay
M Vijay opens up about surfing, his unimpressive record in ODIs and the chance to improve on that, and about learning to express himself more freely
The kid who was competition to Bradman
The player who many thought was a better batsman than the greatest of them all
Johnson back to intimidate with word and deed (119)
At the age of 33, Johnson does not expect to be back for another Ashes campaign and, since being forced to miss last year's World Twenty20 with a toe injury, he has played every game as if it is his last
Despite England's recent surge, Australia will likely prevail in the Ashes thanks to their lethal pace attack, which is suited to all types of pitches
A squad without pace, keepers, or future planning (80)
Five questions for the selectors who picked the second-string squad for the tour of Zimbabwe
Must Buttler keep in all formats? (48)
England could further exploit his worth as a batsman by relieving him of wicketkeeping duties in Tests
Dhoni and Kohli: a clash of ideologies? (43)
The personalities and philosophies of India's two captains could not be more different. That makes for a tricky situation, which India's cricket administration must handle well


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7th Heaven
The Last Call for Aunt Julie
- Episode Description
Matt, Mary and Lucy are eager to spend the Thanksgiving holiday with their friends, but plans change as Eric's sister Julie arrives for an extended visit. Her longtime reputation as Eric's docile, ultra-responsible baby sister is suddenly destroyed when the Camdens learn a secret about her that physically threatens Simon and throws the entire family into turmoil.
- Cast & Crew
Stephen Collins
Catherine Hicks
Barry Watson
David Gallagher
Jessica Biel
- Fan Reviews (9)
Quite possibly the best episode ever of '7th Heaven.'
Aunt Julie Debrah Raffin comes for Thanks Giving and I'm very happy that they chose Debrah for the chrachter i thought she did a fantastic job in this episode we learn that aunt Julie has a dangerous secret
See what drinking can do?
Another wonderful episode!
7th Heaven's premiere season brings memories of this wonderful episode about love, family, and the redemption that ties them together.
- Trivia & Quotes
Quotes (22)
Simon: (to Ruthie) Batman is the world's greatest athlete! Julie: (walks in) Hi kids. Ruthie: Aunt Julie, Simon thinks he's the world's greatest...something. Julie: That's nice...
Eric: Come on, Julie, we're going home. Jack: Who are you, the world's oldest Boy Scout? The lady doesn't want to go yet. Julie: That's right, Jack. You tell him! Eric: (to Jack) I'm the last person you want to mess with right now. I'm taking my sister out of here, and if you don't get your hand off of me, I swear I will beat you to it.
Ruthie: Daddy, she's too old to be your sister. Julie: (on the way upstairs) I heard that.
Simon: (after receiving his sweater) Wow! Julie: And I hope Happy's fits her. I hear she is expecting. Simon: Oh, they're great. Thank you Aunt Julie. Bless you Aunt Julie. May the good Lord bless you and keep you... Eric: (to Julie) Say you're welcome or we'll be here all day. Julie: You're welcome Simon.
Ruthie: You got all pretty again. Julie: Thank you, sweetheart. Ruthie: And you got all nice again, too.
Notes (2)
Stephen Collins and Deborah Raffin worked on many various projects together before "7th Heaven", including the 1984 movie; Threesome.
"7th Heaven" had two more Thankgiving episodes during the show's 9th & 10th seasons.
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subset: commoncrawl


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Far Cry 3
Question from GBP38
What is the best strategy for getting XP fast and easy?
i almost have all of my skills,tattoo is almost complete,outposts are almost all done and i need to find out another way to get xp??????HELP
2 years ago
If you need to level up and have already completed all the quests and liberated all the outposts, then I would suggest relic hunting, and trials of the Rakyat. Relics give you 250 XP each, and trials have an XP reward if you score high enough.
I was maxed out before liberating all outposts but I found like 100 relics. If you need XP I would suggest relic hunting.
2 years ago
I became max level at about the same time I finished the main story. The best and fastest way to earn xp and money is through the main story line in my opinion. I also found all letters of the lost, liberated all outposts, and found 60 relics by the time I finished the main story. Side quests like supply drops can give very good xp as well, if you'd rather not search for relics and such.
2 years ago
My suggestion is to finish the outposts, just clear them all.
This unlocks a setting in the options>gameplay menu to "reset all outposts"
This brings all outposts back under pirate control. (obviously)
Then you can continue to kill pirates and rack up money and Xp to your heat's content.
11 months ago
This question is open with pending answers, but none have been accepted yet
Answer this Question
You must be logged in to answer questions. Please use the login form at the top of this page.
More Questions from This Game
|Can you fast travel between islands?
|How do i make in-game time go by fast?
|Highest fast travel location on the map?
|What is the best strategy for Bow hunting?
|Having trouble finding a couple of chests at the following locations??


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Appointment Booking Calendar allows you to accept online bookings from a set of available time-slots in a calendar.
It's a perfect plugin for people giving classes, like yoga. You can make several bookings for the same date and time, like I need it.
This plugin is really good. I think that is the only plugin for appointments that writes the appointment in your database and has all the features you need to design an appointment system. You are no dependant of other Webs.
New features in the last version are really usefull, and the traslation has been included. Great!
Congratulatios to the development team. They have others plugins really good, as Calculated Fields Form, for instance.
I have bought the pro version of appointments and looking forward to buy the pro version of Calculated Fields Form.
We´re using the software for the organisation of appointments with job applicants.
I can recommend it really very much. I would buy it again - and I WILL buy it again for another project.
Greetings from Austria
Great support by Karen, they are very flexible in adjusting the plugin to our wishes. Keep up the good work!
Hi 5 to Codepeople.
The plug-in is really powerful and easy to customize. As for the support.. A member stood by me during 3 days to solve an issue I had. I'm now using their appointment booking calendar plug-in on my client's web.
5 stars are well deserved, for both the product and the support.
And concerning the paypal feature in the free version... Guys, what else would you use? :D
I'm using it in a photo session booking form where customers can pick the available times to book a session and pay in advance to confirm the it. The plugin fits very well for this purpose, specifically the calendar area for entering the available times are defined and the automatic availability counter that blocks a time after reaching to the maximum capacity specified. I also received free support for changing the calendar size and colors, thank you, I appreciate that.
The calendar in the admin area takes a few seconds in the load process but once is loaded its fast ajax interface excellent, well done. The (email-based) support provided is also efficient.
I thought this was a great plugin, until I tried to figure out how to turn off PayPal forwarding. I spent a day wrestling with it. I then found out - it is not at all obvious in the plugin, and I'm an experienced developer - that this "feature" of PayPal redirection can only be disabled on the pro version.
Codepeople seem to think that paying to *remove* features is a way to make people buy their products. Instead, it's dishonest, especially since they're not at all upfront about it. Codepeople will never get any of my money, and I'll be sure to warn others off their products too.
I like the administration calendar, easy to understand and errors free. The bookings list may be improved with more features, for example buttons to manage the bookings without having to go to the calendar. It's a good plugin and well supported.
Already tried an old version and it doesn't convinced me due to lack of features but I've just re-downloaded it for a second chance and found huge improvements and new features, now I'll keep it installed in my WP, please keep the good work and add more features.
You must log in to submit a review. You can also log in or register using the form near the top of this page.


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A Secular-Humanist, Rational Empiricist, Agnostic Strong-Atheist, Libertarian-Communist, A Pessimistic Irrational Sadist, A Chartalist & Occasional Autodidact!
No members were found matching the criteria specified. We suggest you try the memberlist with no filter applied, to browse all member profiles.
Also why don't you join the community, its fast, easy and free and opens up plenty of great features for you to enjoy.


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Denard Span extended his streak of reaching base to 29 games and added two stolen bases in Sunday's 4-0 Nationals win.
Nationals Talk
Stephen Strasburg brought the heat Sunday against the Phillies.
Stephen Strasburg was just a little bit better than Cole Hamels on Sunday in leading the Nationals to a four-game split.
With Stephen Strasburg and Cole Hamels on the mound, this game was billed as a pitchers duel. It did not disappoint.
It's a marquee pitching matchup at Nationals Park with Stephen Strasburg (7-9, 3.55) going up against Cole Hamels (6-5, 2.55).


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Lovin my new waffle maker. Bin lookin around 4 one 4 so long and wen i saw that amazon had them i was so happy! It works well and definately worth my money i thinkPublished 8 months ago by Crystal
I wish it had more buttons, one that tells you when it is done.Published 11 months ago by Nola Muschett
This buying experience was not a good one. It was purchased as a Christmas gift, guaranteeing delivery by the 24th and it showed up in January. Read morePublished 21 months ago by Trishe Stock
I fairly pleased with the product. The only thing is I wished it would make the waffles a bit thicker.Published 21 months ago by douglas k murray


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People tend to check in during these times:
Add hours
One of the only good pinball spots in DC.
The scene is what's good
It's a nice, kitschy venue for small bands. Everything is cash only inside, but they do have ATMs. That said, DO NOT waste money on their food downstairs. It's microwaved in front of you and subpar.
Great for dancing. Very random in its events. Diverse nights.
Great bar, first class concerts, dance back room, theme parties, live music and food. One of the best places in DC.
Make sure you bring the cash and don't show up late. But a ticket early and hang in the red room.
Was here for a very solid deep house evening.
I see white people
Interesting selection of music on the jukeboxes. A lot of punk rock you can't find elsewhere
Show was great and drinks were good. Will be back soon and so should you!
Live show! Throwing Shade!
Cool atmosphere and great place to catch some indie shows.
Awesome venue for bands.
Take a break from the loud music and dancing by relaxing in the Red Room with fully stocked bar, pool, and pinball or nosh on vegetarian and vegan-friendly delights at the Food for Thought Café. Read more
Practically around the corner from the 9:30 Club this equally amazing music experience offers DC the best of local, national and international indie and alternative music. Read more
Pinback is totally worth getting into and seeing on 9/11/14 at the Black Cat Read more
Love the back room, but the big room is good, too
They use Ticketfly now, not Ticket Alternative.
This is the worst place in DC. Disrespect.
Don't go to the Red Room. Go to El Centro or Masa 14 instead. They're way better. I repeat: do not hang out in the Red Room with its awesome bartenders, couches and great jukebox.
Amazing gig by Public Service Broadcasting last night
Always a good time!
The dance parties in the backstage are the best
Where am I?
Awesome music venue, awful gin&tonic
It was awesome but pee first.
Don't get here early. They won't let you in. Or get there early and drink next door haha
DJ Rich Morel was burning the turntables tonight at The Backstaget. Mixture of club music genres. New fan!
redroom = backbar, 80s, depeche mode vs cure vs smiths vs morrisey, blisspop former home, djs, bands, rock, death, metal, pop, emo, all of the above, seth my fave arnold! jukebox...dive! <3 pass out
Great music fun environment. Eclectic fun crowd!
If you ever see Punk Rock Karaoke on the schedule, ATTEND THAT EVENT! Not only is the event itself a blast, but all proceeds go toward progressive causes!
Doctor Who Happy Hour every Friday @ 7pm
A welcome change from the usual DC nightlife scene. We love coming here for the laidback, rocker vibes. Read more
bring cash
Black Cat Black Cat. Little change for the hooooomeless
My musical go-to spot in DC for the Cure vs. Smiths, Depeche Mode and Duran Duran/New Order nights alone. Party Lights, usually in the back room downstairs, is also fantastic
Awesome Depeche Mode dance party!!!!
The Red Room bar is one of our favorite Happy Hour spots, with an assortment of craft-brews, a pool table, jukebox and pinball machine hang out enough and it will feel like an episode of Cheers!
Cash bar only.. bring cash
Cash only bar in the red room
White Rabbits put on an amazing show! But the sound mixing on the opening act "Guard" was completely hosed; the drummer overrode the rest of the band and the vocals were incomprehensible.
This is the place to see the next big thing! Grab tickets at ticketalternative.com Read more
Best place to see your bands up close-- elevated floorboards near the right wall. Tho, Mr. chubby, diva, bartender there is a poop, bet on the left bar pre show for attentive service. 'laxin. B.C<3.
If you've been drinking, be careful climbing to the seating area in the back. The stairs are kind of steep.
Food was very good, grab a table at the back on the riser for a great view of the evening.
I shoot some great bands here. Must make it a point to hang outside of work like I used to back in my 20s - and the food is way better now ;-)
Beware of jingly drink thief!
If you're not here, you're missing out
Bring enough five dollar bills and quarters to drink PBR tall boys, play the velvet underground on the jukebox and shoot pool all night long.


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Whenever I ask someone what their favorite Final Fantasy game is I often get one of three answers. These answers typically are Final Fantasy VI, Final Fantasy VII or Final Fantasy X. I can understand and respect this. But I'm not here to talk about them. Despite popular opinion Final Fantasy 9 is my favorite game in the series personally and is the second RPG I ever completed.
It can be hard to find variety in local restaurants that offer Halal. In the Dearborn and Metro Detroit area, Halal restaurants that can be found are typically of the traditional Arabic cuisine genre. But, what if there was a restaurant that served delicious Halal entrees Italian style? And, on top of the delectable Halal filet mignon and mouthwatering chicken dishes offered upon request, perhaps some live music and a spectacular view?
"The goal is to be better than I was the day before." That simple ideology seems to be the secret recipe for success in acquiring and maintaining that summer body. Coming from both the pros and from some beginners that have dropped some serious pounds recently, this seems to be the unanimous trick of the trade. Of course, talking to your Doctor before beginning any weight loss or exercise program is strongly recommended.
May isn't typically a time of year associated with voting, but Michigan residents will be hitting the polls on May 5 to decide if our taxes should increase.
Voters will be deciding on State Proposal 15-1, which is slated to adjust Michigan's state sales tax from 6% to 7% if it passes. This is the percentage paid on sales of goods, often appearing at the bottom of retail receipts. The proposal also adjusts how the state manages gas taxes and the programs these taxes fund.
Club room controversy and a crime spree take center stage this issue. This article tells the story of the poster board caper that happened and became unraveled in the three weeks surrounding Globefest. This year Globefest was all fun and games on the surface, as a twist was added, it was made into a completion. But when a completion is made, a dark underbelly of deceit grows beneath it. It all started a week prior to Globefest. The first kidnapping happened on Tuesday, March 31st. A poster board from the past was given to the Community Service club as inspiration for their own Mexico board.
"When you are young you think you are invincible. You can do anything. It's not going to happen to you. I never thought in a million years that it'd happen to us. That happens to other people. You hear it on television…But, it will and it can. It hits home." These words slip out of widower Ann Marie's mouth who lost her husband while he was riding home on his motorcycle. He was hit and killed by a drunk driver in his twenties who made an illegal left turn and fatally struck husband, father, and Desert Sand Storm war veteran Russ Gray.


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List all words ending with benni
Only the word benni was found, nothing longer.
Some random words: pfennig oubliette hyacinth eicosanoid ikat be other
This is not a dictionary, it's a word game wordfinder.
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Find estate agents and letting agents in Little Hadham
Can't find agent? | Report an error
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Lime Property Ltd
Bridge End Albury Road, Little Hadham, Ware, SG11 2DL
Lime Property deliver a highly professional and efficient guaranteed residential letting and ... more
The Gatehouse, Hadham Hall Little Hadham, Ware, SG11 2EB
Residential for sale: 4
Avg. asking price: £520,000
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Residential to rent: 2
Avg. asking rent: £2,102 pcm
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Avg. asking rent: £9,360 pa
Avg. rental listing age: 75 weeks


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Helios Software, LLC, et al. v. Spectorsoft Corporation, C.A. No. 12-81-LPS -MPT, May 22, 2015
Stark, C. J. The court makes various pretrial rulings in advance of a June 15, 2015 jury trial.
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UP BTC Recruitment Application Form 2015
UP BTC Recruitment Application Form 2015 Details of Online A
UP BTC Recruitment Application Form 2015 Details of Online Application & Registration at upbasiceduparishad.gov.in
The Uttar Pradesh Basic Education Board has revealed the complete details of online applications for recruitment in the 15,000 vacancies available under Assistant Teacher Posts. The candidates can submit their application forms at the website mentioned latest by the closing dates specified for this purpose i.e. 6th February 2015. The candidates in order to participate in concerned recruitment must be at least graduation passed from any disciplines along with BTC qualified. The willing and eligible candidates shall be hired in the post mentioned through test/ interview conducted for this purpose on dates scheduled.
View More For Latest Sarkari Naukri Details
Details of UP BTC Recruitment Application Form 2015-
The candidates should submit their application forms online at the website of the Board i.e. upbasiceduparishad.gov.in in the manner as prescribed in notification as well as website concerned. Only eligible candidates should apply online for the post of Assistant Teachers. Follow the steps as detailed below to submit your applications online for UP BTC Recruitment 2015.
Steps to Apply Online for UP BTC Recruitment 2015-
1) The applicants should log on to the official website of UP Basic Education Board.
2) Read the complete instructions available online for the online registration to the concerned recruitment.
3) The application forms can be filled in only English Language.
4) Find the online registration links for concerned recruitment from the website "Recruitment" section.
5) Fill all the required details in the application form and upload your latest photograph as well as signatures (if compulsory).
6) Submit the application form after confirming that all details are duly entered in the form.
7) The applicants must pay the required amount of application fee through E- Challan or SBI Online Application Fee Payment link provided for this purpose.
8) Print your online filled in application form after submitting it to be retained for future references, if any.
9)Application forms incomplete or submitted after the due dates mentioned shall not be accepted by Board.
Important Dates-
Last Date for Online Application: 6th February 2015
Last Date for Payment of Application Fee Online: 10th February 2015
Last Date for Application Form Print: 5th March 2015
To get more details on UP BTC Recruitment Application Form 2015 & Online Application, click here
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posted by k.k. saxena at october 12,2012
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Silly Thing is a Hong Kong based multi-disciplinary creative production agency. It publishes the Chinese language fashion/culture weekly periodical Milk (Hong Kong/China/Taiwan), monthly magazine Milk X, and quarterly magazine Obscura, alongside offering visual production services for global clients, branding services, digital production, and event management.
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Category: Eat + Drink Articles
Frustrated with the area's dearth of delicious late-night eats—the kind you wolf down on your tipsy way home from the bar—Campagne alums Taber Turpin and Michael Pitts decided to fill the void by opening Taco Gringos (Capitol Hill, 1510 E Olive Way; no phone; tacogringos.com), a takeout-only taco shop that doesn't even open 'til 8 p.m. (and usually stays open past 2:30 a.m.). Taco Gringos roughly translates to "white guy tacos," and Turpin and Pitts make no claims about authenticity. The shop's name drives home the point that they're making tacos in their own unique style. That style involves tender, warm, palm-size corn tortillas enclosing one of the three rotating fillings offered each night. On my visits I devoured a braised-pork taco topped with a little chopped cilantro and a squeeze of lime (it reminded me of some of the best carnitas I've ever had), and a pulled-chicken taco, whose nice acidic twang from the tomatillo in its sauce balanced the meat's deeply savory flavor. Some nights you'll find chorizo tacos; on others, roasted-rabbit tacos in an incredible house-made pasilla sauce. All tacos are just $2, and worth every penny.


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
27 year old woman | San Diego, CA, USA | Seeking men 25-30 within 10 miles of Philadelphia, PA
No more rhymes now, I mean it! Anybody want a peanut??
I am passionate about my family and caring for others - although nursing lends itself to these things it is also a huge part of my personality and how I choose to spend my time. Although I grew up in San Diego, I just moved back from the east coast so time to get used to the ocean being on the other side (right side) lol I would love to travel - especially to Italy, Greece, Morocco, Portugal, Australia/New Zealand, basically everywhere! Love trying new things and interesting restaurants in the city, being active/outdoors, hanging with friends/family, playing sports (vb, tennis). I am looking for someone who is trustworthy, has a sense of humor, and is goal oriented. I would like someone who has their own passions that I can mesh with mine. Random Stuff: I will school anyone who wants to play Mariokart or Supersmash brothers on Nintendo 64 ... bring it on; Dogs make me extremely happy, they are the best kind of therapy out there; I will only eat dark chocolate, it's the only type of chocolate to like; I'm very skiddish (I run) around bugs, especially spiders and bees so I need someone who can kill spiders for me!; I would be lying if I said I wasn't competitive, even in boardgames/cardgames I am in it to win it haha; I love the color blue and the smell of roses; I'm possibly the most accident prone person you will ever meet, have had my dad put several casts on me in my backyard haha; I wish I could trap the smell of the ocean, it's one of my favorite things!
Cooking , Movies/Videos , Music and concerts , Nightclubs/Dancing , Playing cards , Playing sports , Travel/Sightseeing , Watching sports
Aerobics, Bowling, Dancing, Running, Tennis / Racquet sports, VolleyBall, Walking / Hiking, Yoga
I exercise 3-4 times per week.
Don't display my sign
I like Cats, Dogs, Horses
Middle of the Road
Love to be near the ocean/beach, mission beach for vb. Just moved back so I have yet to re-explore my hometown! Really like to try out new restaurants, farmer's markets, live music/concerts.
University of California, Berkeley, Berkeley, CA
Favorite TV shows= new girl, glee, lost, friends, sherlock, modern family Music = EVERYTHING except rap - right now imagine dragons, jason mraz Food = definitely greek/mediterranean, good salads :), sushi, indian
Going on a good run or playing tennis/vb. I also love to go to sporting events, dancing, good restaurants or out in the city. Enjoy staying in to watch a good movie, read a favorite book, play boardgames, exploring! Random road trips are always good!
Last book was Name of the Wind / Game of Thrones Book 5 - I like scifi/fantasy so if you are into those kinds of books I'll tell you what I'm reading haha; next possible is re-reading Hobbit!
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'5" (165cms)
|5'7" (170cms) to 6'3" (190cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned
|No preference
|Light brown
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker, Moderately
|Medical / Dental / Veterinary / Fitness
|Administrative / Secretarial, Artistic / Creative / Performance, Executive / Management, Financial / Accounting / Real Estate, Legal, Medical / Dental / Veterinary / Fitness, Political / Govt / Civil Service / Military, Sales / Marketing, Self-Employed / Entrepreneur, Student, Education / Teacher / Professor, Technical / Science / Computers / Engineering, Nonprofit / Volunteer / Activist, Law enforcement / Security / Military, Architecture / Interior design
I am an acute care nurse practitioner in the medical ICU
|$50,001 to $75,000
|$35,001 to $50,000, $50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married
|Never Married
|Have kids:
|Yes, and they sometimes live at home, No, Yes, and they live away from home
|Wants kids:
|Definitely, Someday
|White / Caucasian
|Asian, East Indian, Latino / Hispanic, Pacific Islander, White / Caucasian
|Christian / Catholic
|Christian / Catholic, Spiritual but not religious, Christian / Other
|English, Spanish
|Graduate degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral


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Dan Peters Memorial Scholarship Golf Outing at Portage Country Club
- Sports & Fitness
- 240 North Portage Path, Akron, OH, 44303
Walsh University's 47th Annual Business Club Scholarship Luncheon
Presented by Walsh University
Friday, April 12, 2013 from 11:30 AM to 1:00 PM (EDT)
Walsh University's DeVille School of Business & the ICF Institute for the Study of the Intelligent Community invite you to attend the
47th Annual Business Club Scholarship Luncheon:
A Story of Entrepreneurship and the Technology Revolution in Northeast Ohio
Friday, April 12
11:30 a.m. to 1 p.m.
Keynote Speaker
A.J. Hyland
Former CEO, Hyland Software
Widely regarded as the poster child of Northeast Ohio's information technology industry, at just 29, AJ became CEO of Hyland Software, one of the largest independent software vendors in the world. Hyland has since grown to employ 1500 worldwide, the majority being here in Northeast Ohio. In 2012, AJ received Ernst & Young's Entrepreneur of the Year Award in the field of technology. Come hear firsthand this amazing story of entrepreneurship and how it's helping to reenergize and revolutionize the field of technology in Northeast Ohio.
$25 per person
$800 for Event Sponsorship
(Includes a table of 8 at the luncheon, special recognition in the event program and verbal recognition during the event.)
All proceeds benefits Walsh University business scholarships.
For more information, please contact Karen Khourey
at firstname.lastname@example.com or by phone at (330) 490-7111.
Registration is now closed.
Presenting Sponsor:
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Are you Niklas Lindegardh?Claim your profile
Publications (131)620.35 Total impact
Article: Population pharmacokinetics of piperaquine in young Ugandan children treated with dihydroartemisinin-piperaquine for uncomplicated malaria[Show abstract] [Hide abstract]
ABSTRACT: This prospective trial investigated the population pharmacokinetics of piperaquine, given with dihydroartemisinin to treat uncomplicated malaria in 107 Ugandan children 6 months to 2 years old, an age group previously unstudied. Current weight-based dosing does not adequately address physiological changes in early childhood. Patients were administered standard three-day oral doses and provided 1,282 capillary plasma concentrations from 218 malaria episodes. Less than 30% of treatments achieved 57 ng/mL on day 7. A three-compartment model with first-order absorption described the data well. Age had a statistically significant effect (p<0.005) on clearance/bioavailability in a model that accounts for allometric scaling. Simulations demonstrated that higher doses in all children, but especially in those with lower weight for age, are required for adequate piperaquine exposure, though safety and tolerance will need to be established. These findings support other evidence that both weight and age-specific guidelines for piperaquine dosing in children are urgently needed. This article is protected by copyright. All rights reserved. © 2015 American Society for Clinical Pharmacology and Therapeutics.Clinical Pharmacology & Therapeutics 03/2015; DOI:10.1002/cpt.104 · 7.39 Impact Factor
Article: Efficacy and Day 7 Plasma Piperaquine Concentrations in African Children Treated for Uncomplicated Malaria with Dihydroartemisinin-Piperaquine[Show abstract] [Hide abstract]
ABSTRACT: One promising new Artemisinin-based combination therapies (ACTs) is dihydroartemisinin-piperaquine (DHA-PQ). However, the pharmacokinetics of piperaquine and the relationship between drug levels and clinical efficacy are incompletely characterized, particularly in children.PLoS ONE 08/2014; 9(8):e103200. DOI:10.1371/journal.pone.0103200 · 3.53 Impact Factor
Article: Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum infection in Burkina Faso[Show abstract] [Hide abstract]
ABSTRACT: Objectives: Mefloquine/artesunate has recently been developed as a fixed-dose combination, providing a promising rescue/alternative treatment for malaria during pregnancy. However, limited data are available on the effect of pregnancy on its pharmacokinetic properties. This study was conducted to assess the pharmacokinetic properties of mefloquine/carboxymefloquine and artesunate/dihydroartemisinin in pregnant and non-pregnant women with uncomplicated malaria. Methods: Twenty-four women in their second and third trimesters of pregnancy and 24 paired non-pregnant women were enrolled. All patients were treated for uncomplicated Plasmodium falciparum malaria with a standard fixed-dose combination of oral mefloquine and artesunate one daily over 3 days. Frequent blood samples were collected before treatment and at scheduled times post-dose for the drug measurements and pharmacokinetic analyses. The study was registered at www.clinicaltrials.gov (identifier: NCT00701961). Results: The total median exposure to mefloquine and dihydroartemisinin was not significantly different between the pregnant and non-pregnant women (P.0.05). Therewas a trend of higher exposure tomefloquine in the pregnant women, but this difference did not reach statistical significance (656700 versus 542400 h×ng/mL; P¼0.059). However, the total exposure to carboxymefloquine was 49% lower during pregnancy (735600 versus 1499000 h×ng/mL; P,0.001) and the total drug exposure to artesunate was 42% higher during pregnancy (89.0 versus 62.9 h×ng/mL; P¼0.039) compared with non-pregnant controls. Conclusions: The plasma levels of mefloquine and dihydroartemisinin appeared to be similar in both pregnant and non-pregnant women, but there were significant differences in carboxymefloquine and artesunate exposure. The data presented here do not warrant a dose adjustment in pregnant patients, but an extensive analysis of the data could provide a better understanding of these findings.Journal of Antimicrobial Chemotherapy 06/2014; 2014 Jun 2.(9). DOI:10.1093/jac/dku154 · 5.44 Impact Factor
Article: Benefits of a Pharmacology Antimalarial Reference Standard and Proficiency Testing Program Provided by the Worldwide Antimalarial Resistance Network (WWARN)[Show abstract] [Hide abstract]
ABSTRACT: Comprehensive assessment of antimalarial drug resistance should include measurements of antimalarial blood or plasma concentrations in clinical trials and in individual assessments of treatment failure, so that true resistance can be differentiated from inadequate drug exposure. Pharmacometric modelling is necessary to assess pharmacokinetic-pharmacodynamic relationships in different populations to optimize dosing. To accomplish both effectively, and to allow comparison of data from different laboratories, it is essential that drug concentration measurement is accurate. Proficiency testing (PT) of laboratory procedures are necessary for verification of assay results. Within WWARN, the goal of the quality assurance/quality control (QA/QC) programme is to facilitate and sustain high-quality antimalarial assays. The QA/QC programme consists of an international PT programme for pharmacology laboratories and a reference material (RM) programme for the provision of antimalarial drug standards, metabolites and internal standards for laboratory use. The RM programme currently distributes accurately weighed quantities of antimalarial drug standards, metabolites and internal standards to 44 pharmacology, in vitro and drug quality laboratories. The pharmacology PT programme has sent samples to 8 laboratories in 4 rounds of testing. WWARN technical experts have provided advice for correcting identified problems to improve performance of subsequent analysis, and ultimately improved the quality of data. Many participants have demonstrated substantial improvements over subsequent rounds of PT. The WWARN QA/QC programme has improved the quality and value of antimalarial drug measurement in laboratories globally. It is a model that has potential to be applied to strengthening laboratories more widely and improving the therapeutics of other infectious diseases.Antimicrobial Agents and Chemotherapy 04/2014; 58(7). DOI:10.1128/AAC.02362-14 · 4.45 Impact Factor
Article: Preliminary pharmaceutical development of antimalarial-antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas.[Show abstract] [Hide abstract]
ABSTRACT: Artemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas. The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective against both malaria and bacterial infections. Analytical and pharmacotechnical development, followed by in vitro and in vivo evaluation, were conducted for various AMAZ coformulations. Of the formulations tested, stability was highest for dry solid forms and bioavailability for hard gelatin capsules; AM release from AMAZ rectodispersible tablet was suboptimal due to a modification of its micro-crystalline structure.International Journal of Pharmaceutics 04/2014; DOI:10.1016/j.ijpharm.2014.04.023 · 3.79 Impact Factor
Article: Pharmacokinetics of Orally Administered Oseltamivir in Healthy Obese and Nonobese Thai Subjects[Show abstract] [Hide abstract]
ABSTRACT: Oseltamivir is the most widely used anti-influenza drug. In the 2009 H1N1 pandemic, in which the influenza viruses were oseltamivir sensitive, obesity was identified as a risk factor for severe disease and unfavorable outcomes. The aim of this study was to investigate the pharmacokinetic properties of oseltamivir and its active metabolite, oseltamivir carboxylate, in obese and nonobese healthy subjects. A single-dose, randomized, two-sequence crossover study was conducted in 12 obese and 12 nonobese healthy Thai volunteers. Each volunteer was given 75 mg and 150 mg oseltamivir orally with an intervening washout period of more than 3 days. The pharmacokinetic properties of oseltamivir and oseltamivir carboxylate were evaluated using a noncompartmental approach. The median (range) body mass indexes (BMIs) for obese subjects were 33.8 kg/m2 (30.8 to 43.2) and 22.2 (18.8 to 24.2) for nonobese subjects. The pharmacokinetic parameters of oseltamivir carboxylate, the active metabolite of oseltamivir, were not significantly different between obese and nonobese subjects for both 75-mg and 150-mg doses. Both doses were well tolerated. Despite the lower dose per kilogram body weight in obese subjects, there was no significant difference in the exposure of oseltamivir carboxylate between the obese and nonobese groups. Standard dosing is appropriate for obese subjects. (The study was registered at ClinicalTrials.gov under registration no. NCT 01049763.) FOOTNOTES Received 3 September 2013. Returned for modification 20 November 2013. Accepted 17 December 2013. Address correspondence to Podjanee Jittamala, podjanee{at}tropmedres.ac. Published ahead of print 23 December 2013 Copyright © 2014 Jittamala et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.Antimicrobial Agents and Chemotherapy 03/2014; 58(3). DOI:10.1128/AAC.01786-13 · 4.45 Impact Factor
Article: Population Pharmacokinetic Assessment of the Effect of Food on Piperaquine Bioavailability in Patients with Uncomplicated Malaria[Show abstract] [Hide abstract]
ABSTRACT: Previously published literature reports a varying impact of food on the oral bioavailability of piperaquine. The aim of this study was to use a population modeling approach to investigate the impact of concomitant intake of a small amount of food on piperaquine pharmacokinetics. This was an open randomized comparison of piperaquine pharmacokinetics when administered as a fixed oral formulation once daily for three days with (n=15) and without (n=15) concomitant food to patients with uncomplicated P. falciparum malaria in Thailand. Nonlinear mixed-effects modeling was used to characterize the pharmacokinetics of piperaquine and the influence of concomitant food intake. A modified Monte-Carlo mapped power approach was applied to evaluate the relationship between statistical power and a varying degree of covariate effect sizes of the given study design. Piperaquine population pharmacokinetics were described well in fasting and fed patients by a three-compartment distribution model with flexible absorption. The final model showed a 25% increase in relative bioavailability per dose occasion during the recovery from malaria but demonstrated no clinical impact of concomitant intake of a low-fat meal. Body weight and age were both significant covariates in the final model. The novel power approach concluded that the study was adequately powered to detect a food effect of at least 35%. This modified Monte-Carlo mapped power approach may be a useful tool for evaluating the power to detect true covariate effects in mixed-effects modeling and a given study design. A small amount of food does not affect piperaquine absorption significantly in acute malaria.Antimicrobial Agents and Chemotherapy 01/2014; 58(4). DOI:10.1128/AAC.02318-13 · 4.45 Impact Factor
Article: Disposition of amodiaquine and desethylamodiaquine in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy.[Show abstract] [Hide abstract]
ABSTRACT: Artesunate plus amodiaquine is used for malaria treatment in regions with overlapping HIV endemicity. Co-administration of artesunate/amodiaquine with antiretroviral therapy (ART) may result in drug-drug interactions, but minimal data exist. This study evaluated the impact of nevirapine-based ART, containing a backbone of zidovudine and lamivudine, on the disposition of amodiaquine and its active metabolite, desethylamodiaquine (DEAQ). This was an open-label, parallel-group pharmacokinetic comparison between HIV-infected, adult subjects receiving steady-state nevirapine-based ART (n = 10) and ART-naive subjects (control group, n = 11). All subjects received a loose formulation of artesunate/amodiaquine (200/600 mg) daily for 3 days, with serial pharmacokinetic sampling over 96 h following the final dose of artesunate/amodiaquine. Amodiaquine and DEAQ were quantified using a validated HPLC method with UV detection. Pharmacokinetic parameters were determined using standard non-compartmental methods. Exposures to both amodiaquine and DEAQ were significantly lower in the nevirapine-based ART group compared with the control group (amodiaquine AUC0-24 145 versus 204 ng·h/mL, P = 0.02; DEAQ AUC0-96 14 571 versus 21 648 ng·h/mL, P < 0.01). The AUCDEAQ/AUCamodiaquine ratio was not different between groups (ART group 116 versus control group 102, P = 0.67). Subjects on nevirapine-based ART had lower exposure to both amodiaquine and DEAQ (28.9% and 32.7%, respectively). Consequently, this may negatively impact the effectiveness of artesunate/amodiaquine in HIV-infected individuals on this ART combination.Journal of Antimicrobial Chemotherapy 01/2014; DOI:10.1093/jac/dkt513 · 5.44 Impact Factor
Article: Transient increase of interferon-stimulated genes and no clinical benefit by Chloroquine treatment during acute SIV infection of macaques.[Show abstract] [Hide abstract]
ABSTRACT: Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected Rhesus macaques similarly to HIV-infected humans. In contrast, SIV infection of natural hosts is characterized by a down regulation of innate acute responses to the virus within few weeks from the infection and results in limited pathology. Chloroquine (CQ) has been used in the treatment or prevention of malaria and has recently been shown to cause a decrease of immune-activation and CD4-cell loss in HIV infected individuals treated with antiretroviral therapy. Here, we treated Rhesus macaques with CQ during the acute phase of SIVmac251 infection with intent to decrease viral-induced immune activation, and possibly limit disease progression. Contrary to what is expected, CQ treatment resulted in a temporary increased expression of IFN-stimulating genes and it worsened the recovery of CD4+ T cells in the blood. Our findings confirm recent results observed in asymptomatic HIV infection patients, and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy.AIDS research and human retroviruses 11/2013; DOI:10.1089/AID.2013.0218 · 2.46 Impact Factor
Article: Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda[Show abstract] [Hide abstract]
ABSTRACT: Pregnancy alters the pharmacokinetic properties of many antimalarial compounds. The objective of this study was to evaluate the pharmacokinetic properties of lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Uganda after a standard fixed oral artemether-lumefantrine treatment. Dense venous (n = 26) and sparse capillary (n = 90) lumefantrine samples were drawn from pregnant patients. A total of 17 nonpregnant women contributed with dense venous lumefantrine samples. Lumefantrine pharmacokinetics was best described by a flexible absorption model with multiphasic disposition. Pregnancy and body temperature had a significant impact on the pharmacokinetic properties of lumefantrine. Simulations from the final model indicated 27% lower day 7 concentrations in pregnant women compared with nonpregnant women and a decreased median time of 0.92 and 0.42 days above previously defined critical concentration cutoff values (280 and 175 ng/ml, respectively). The standard artemether-lumefantrine dose regimen in P. falciparum malaria may need reevaluation in nonimmune pregnant women.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e83; doi:10.1038/psp.2013.59; advance online publication 13 November 2013.11/2013; 2(11):e83. DOI:10.1038/psp.2013.59
Article: Liquid chromatographic-mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria[Show abstract] [Hide abstract]
ABSTRACT: Acidosis is an important cause of mortality in severe falciparum malaria. Lactic acid is a major contributor to metabolic acidosis, but accounts for only one-quarter of the strong anion gap. Other unidentified organic acids have an independent strong prognostic significance for a fatal outcome. In this study, a simultaneous bio-analytical method for qualitative and quantitative assessment in plasma and urine of eight small organic acids potentially contributing to acidosis in severe malaria was developed and validated. High-throughput strong anion exchange solid-phase extraction in a 96-well plate format was used for sample preparation. Hydrophilic interaction liquid chromatography (HILIC) coupled to negative mass spectroscopy was utilized for separation and detection. Eight possible small organic acids; l-lactic acid (LA), α-hydroxybutyric acid (aHBA), β-hydroxybutyric acid (bHBA), p-hydroxyphenyllactic acid (pHPLA), malonic acid (MA), methylmalonic acid (MMA), ethylmalonic acid (EMA) and α-ketoglutaric acid (aKGA) were analyzed simultaneously using a ZIC-HILIC column with an isocratic elution containing acetonitrile and ammonium acetate buffer. This method was validated according to U.S. Food and Drug Administration guidelines with additional validation procedures for endogenous substances. Accuracy for all eight acids ranged from 93.1% to 104.0%, and the within-day and between-day precisions (i.e. relative standard deviations) were lower than 5.5% at all tested concentrations. The calibration ranges were: 2.5-2500μg/mL for LA, 0.125-125μg/mL for aHBA, 7.5-375μg/mL for bHBA, 0.1-100μg/mL for pHPLA, 1-1000μg/mL for MA, 0.25-250μg/mL for MMA, 0.25-100μg/mL for EMA, and 30-1500μg/mL for aKGA. Clinical applicability was demonstrated by analyzing plasma and urine samples from five patients with severe falciparum malaria; five acids had increased concentrations in plasma (range LA=177-1169μg/mL, aHBA=4.70-38.4μg/mL, bHBA=7.70-38.0μg/mL, pHPLA=0.900-4.30μg/mL and aKGA=30.2-32.0) and seven in urine samples (range LA=11.2-513μg/mL, aHBA=1.50-69.5μg/mL, bHBA=8.10-111μg/mL, pHPLA=4.30-27.7μg/mL, MMA=0.300-13.3μg/mL, EMA=0.300-48.1μg/mL and aKGA=30.4-107μg/mL). In conclusion, a novel bioanalytical method was developed and validated which allows for simultaneous quantification of eight small organic acids in plasma and urine. This new method may be a useful tool for the assessment of acidosis in patients with severe malaria, and other conditions complicated by acidosis.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 10/2013; 941C:116-122. DOI:10.1016/j.jchromb.2013.10.005 · 2.69 Impact Factor
Article: Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial[Show abstract] [Hide abstract]
ABSTRACT: Abstract OBJECTIVE: To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza. DESIGN: Double blind randomised trial. SETTING: Thirteen hospitals in Indonesia, Singapore, Thailand, and Vietnam. PARTICIPANTS: Patients aged ≥ 1 year admitted to hospital with confirmed severe influenza. INTERVENTIONS: Oral oseltamivir at double dose (150 mg twice a day/paediatric equivalent) versus standard dose (75 mg twice a day/paediatric equivalent). MAIN OUTCOME MEASURE: Viral status according to reverse transcriptase polymerase chain reaction (RT-PCR) for influenza RNA in nasal and throat swabs on day five. RESULTS: Of 326 patients (including 246 (75.5%) children aged <15), 165 and 161 were randomised to double or standard dose oseltamivir, respectively. Of these, 260 (79.8%) were infected with influenza virus A (133 (40.8%) with A/H3N2, 72 (22.1%) with A/H1N1-pdm09, 38 (11.7%) with seasonal A/H1N1, 17 (5.2%) with A/H5N1) and 53 (16.2%) with influenza virus B. A further 3.9% (13) were false positive by rapid antigen test (negative by RT-PCR and no rise in convalescent haemagglutination inhibition titers). Similar proportions of patients were negative for RT-PCR on day five of treatment: 115/159 (72.3%, 95% confidence interval 64.9% to 78.7%) double dose recipients versus 105/154 (68.2%, 60.5% to 75.0%) standard dose recipients; difference 4.2% (-5.9 to 14.2); P=0.42. No differences were found in clearance of virus in subgroup analyses by virus type/subtype, age, and duration of illness before randomisation. Mortality was similar: 12/165 (7.3%, 4.2% to 12.3%) in double dose recipients versus 9/161 (5.6%, 3.0% to 10.3%) in standard dose recipients. No differences were found between double and standard dose arms in median days on supplemental oxygen (3 (interquartile range 2-5) v 3.5 (2-7)), in intensive care (4.5 (3-6) v 5 (2-11), and on mechanical ventilation (2.5 (1-16) v 8 (1-16)), respectively. No important differences in tolerability were found. CONCLUSIONS: There were no virological or clinical advantages with double dose oseltamivir compared with standard dose in patients with severe influenza admitted to hospital. REGISTRATION: Clinical Trials NCT00298233.
Article: Comparison of Oseltamivir and Oseltamivir Carboxylate Concentrations in Venous Plasma, Venous Blood, and Capillary Blood in Healthy Volunteers[Show abstract] [Hide abstract]
ABSTRACT: Oseltamivir and oseltamivir carboxylate concentrations were measured in venous plasma, venous blood, and capillary blood taken simultaneously from 24 healthy volunteers. Median (range) venous blood to plasma ratios were 1.42 (0.920-1.97) for oseltamivir and 0.673 (0.564-0.814) for oseltamivir carboxylate. Capillary blood/venous plasma ratios were 1.32 (0.737-3.16) for oseltamivir and 0.685 (0.502-1.34) for oseltamivir carboxylate. Oseltamivir concentrations in venous and capillary blood were similar. Oseltamivir carboxylate showed a time-dependent distribution between venous and capillary blood.Antimicrobial Agents and Chemotherapy 03/2013; 57(6). DOI:10.1128/AAC.02408-12 · 4.45 Impact Factor
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ABSTRACT: Plasmodium falciparum resistance to artemisinins, the first line treatment for malaria worldwide, has been reported in western Cambodia. Resistance is characterized by significantly delayed clearance of parasites following artemisinin treatment. Artemisinin resistance has not previously been reported in Myanmar, which has the highest falciparum malaria burden among Southeast Asian countries. A non-randomized, single-arm, open-label clinical trial of artesunate monotherapy (4 mg/kg daily for seven days) was conducted in adults with acute blood-smear positive P. falciparum malaria in Kawthaung, southern Myanmar. Parasite density was measured every 12 hours until two consecutive negative smears were obtained. Participants were followed weekly at the study clinic for three additional weeks. Co-primary endpoints included parasite clearance time (the time required for complete clearance of initial parasitemia), parasite clearance half-life (the time required for parasitemia to decrease by 50% based on the linear portion of the parasite clearance slope), and detectable parasitemia 72 hours after commencement of artesunate treatment. Drug pharmacokinetics were measured to rule out delayed clearance due to suboptimal drug levels. The median (range) parasite clearance half-life and time were 4.8 (2.1-9.7) and 60 (24-96) hours, respectively. The frequency distributions of parasite clearance half-life and time were bimodal, with very slow parasite clearance characteristic of the slowest-clearing Cambodian parasites (half-life longer than 6.2 hours) in approximately 1/3 of infections. Fourteen of 52 participants (26.9%) had a measurable parasitemia 72 hours after initiating artesunate treatment. Parasite clearance was not associated with drug pharmacokinetics. A subset of P. falciparum infections in southern Myanmar displayed markedly delayed clearance following artemisinin treatment, suggesting either emergence of artemisinin resistance in southern Myanmar or spread to this location from its site of origin in western Cambodia. Resistance containment efforts are underway in Myanmar. Australian New Zealand Clinical Trials Registry ACTRN12610000896077.PLoS ONE 03/2013; 8(3):e57689. DOI:10.1371/journal.pone.0057689 · 3.53 Impact Factor
Article: Effect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria[Show abstract] [Hide abstract]
ABSTRACT: Background. The emergence of Plasmodium falciparum resistance to artemisinins on the Cambodian and Myanmar-Thai borders poses severe threats to malaria control. We investigated whether increasing or splitting the dose of the short-half-life drug artesunate improves parasite clearance in falciparum malaria in the 2 regions. Methods. In Pailin, western Cambodia (from 2008 to 2010), and Wang Pha, northwestern Thailand (2009–2010), patients with uncomplicated falciparum malaria were randomized to oral artesunate 6 mg/kg/d as a once-daily or twice-daily dose for 7 days, or artesunate 8 mg/kg/d as a once-daily or twice-daily dose for 3 days, followed by mefloquine. Parasite clearance and recrudescence for up to 63 days of follow-up were assessed. Results. A total of 159 patients were enrolled. Overall median (interquartile range [IQR]) parasitemia half-life (half-life) was 6.03 (4.89–7.28) hours in Pailin versus 3.42 (2.20–4.85) hours in Wang Pha (P = .0001). Splitting or increasing the artesunate dose did not shorten half-life in either site. Pharmacokinetic profiles of artesunate and dihydroartemisinin were similar between sites and did not correlate with half-life. Recrudescent infections occurred in 4 of 79 patients in Pailin and 5 of 80 in Wang Pha and was not different between treatment arms (P = .68). Conclusions. Increasing the artesunate treatment dose up to 8 mg/kg/d or splitting the dose does not improve parasite clearance in either artemisinin resistant or more sensitive infections with P. falciparum. Clinical Trials Registration. ISRCTN15351875.Clinical Infectious Diseases 03/2013; 56(5):e48-e58. DOI:10.1093/cid/cis958 · 9.42 Impact Factor
Article: Pharmacokinetic predictors for recurrent malaria after dihydroartemisinin-piperaquine treatment of uncomplicated malaria in Ugandan infants.[Show abstract] [Hide abstract]
ABSTRACT: Background. Despite its primary use in children, pharmacokinetic/pharmacodynamic (PK/PD) data on dihydroartemisinin-piperaquine (DP) in young children is lacking.Methods. We conducted a prospective PK/PD study of piperaquine in 107 young children in Uganda. Samples were collected up to 28 days after 218 treatments for malaria occurring over 5 months of follow-up. Malaria follow-up was conducted actively to day 28 and passively to day 63.Results. Median day-7 capillary piperaquine concentration was 41.9 ng/mL. Low piperaquine concentrations were associated with the risk of recurrent malaria up to 42 days, primarily in those receiving trimethoprim-sulfamethoxazole (TS) prophylaxis. In children not taking TS, piperaquine concentrations were only modestly associated with the risk of recurrent malaria. However, for children on TS, associations were strong and evident for all sampling days. Day 7 concentrations ≤27.3 ng/mL were highly predictive of the risk for recurrent malaria. Notably, of 132 cases of recurrent malaria, 119 had detectable piperaquine concentrations at the time of presentation with recurrent malaria.Conclusions. These piperaquine PK/PD data represent the first in children <2 years of age. Piperaquine exposure on day 7 correlates with risk of recurrent malaria after DP treatment in children on TS prophylaxis. Interestingly, despite strong associations, infants remain at risk for malaria even in the presence of residual levels of piperaquine.The Journal of Infectious Diseases 02/2013; DOI:10.1093/infdis/jit078 · 5.78 Impact Factor
Article: Population Pharmacokinetics of Intramuscular Artesunate in African Children With Severe Malaria: Implications for a Practical Dosing Regimen[Show abstract] [Hide abstract]
ABSTRACT: Parenteral artesunate (ARS) is the drug of choice for the treatment of severe malaria. Pharmacokinetics data on intramuscular ARS are limited with respect to the main treatment group that carries the highest mortality, namely, critically ill children with severe malaria. A population pharmacokinetic study of ARS and dihydroartemisinin (DHA) was conducted from sparse sampling in 70 Tanzanian children of ages 6 months to 11 years. All the children had been admitted with severe falciparum malaria and were treated with intramuscular ARS (2.4 mg/kg at 0, 12, and 24 h). Venous plasma concentration-time profiles were characterized using nonlinear mixed-effects modeling (NONMEM). A one-compartment disposition model accurately described first-dose population pharmacokinetics of ARS and DHA. Body weight significantly affected clearance and apparent volume of distribution (P < 0.001), resulting in lower ARS and DHA exposure levels in smaller children. An adapted dosing regimen including a practical dosing table per weight band is proposed for young children based on the pharmacokinetic model.Clinical Pharmacology & Therapeutics (2013); advance online publication 20 March 2013. doi:10.1038/clpt.2013.26.Clinical Pharmacology & Therapeutics 02/2013; 93(5). DOI:10.1038/clpt.2013.26 · 7.39 Impact Factor
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ABSTRACT: Neuraminidase inhibitors are the mainstay of anti-influenza treatment. Oseltamivir is the most widely used drug but is currently available only as an oral formulation. Resistance spreads rapidly in seasonal H1N1 influenza A viruses, which were universally resistant in 2008, because of the H275Y mutation in the neuraminidase (NA) gene. Oseltamivir is a prodrug for the active carboxylate metabolite. Ex vivo conversion in blood samples may have confounded early pharmacokinetic studies. Oseltamivir shows dose linear kinetics, and oseltamivir carboxylate has an elimination half-life (t(1/2) β) after oral administration in healthy individuals of approximately 7.7 hours. Oseltamivir carboxylate is eliminated primarily by tubular secretion, and both clearance and tissue distribution are reduced by probenecid. The H275Y mutation in NA confers high-level oseltamivir resistance and intermediate peramivir resistance but does not alter zanamivir susceptibility. Zanamivir is available as a powder for inhalation, and a parenteral form is under development. Zanamivir distributes in an apparent volume of distribution approximating that of extracellular water and is rapidly eliminated (t(1/2) β of approximately 3.0 hours). Peramivir is slowly eliminated (t(1/2) β of 7.7-20.8 hours) and is prescribed as either a once-daily injection or as a single infusion. Laninamivir is a recently developed slowly eliminated compound for administration by inhalation.The Journal of Clinical Pharmacology 02/2013; 53(2):119-39. DOI:10.1177/0091270012440280 · 2.47 Impact Factor
Article: Combination therapy with amantadine, oseltamivir and ribavirin for influenza A infection: safety and pharmacokinetics[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Antiviral resistance among influenza A viruses is associated with high morbidity and mortality in immunocompromised hosts. However, treatment strategies for drug-resistant influenza A are not established. A triple combination antiviral drug (TCAD) regimen consisting of amantadine, oseltamivir, and ribavirin demonstrated good efficacy in an animal model. METHODS: We first analyzed pharmacokinetics of TCAD therapy in healthy volunteers. We then performed a pilot study of TCAD in patients undergoing chemotherapy or hematopoietic cell transplantation. Amantadine (75 mg), oseltamivir (50 mg), and ribavirin (200 mg) were administered three times a day for 10 days. The safety and pharmacokinetics of TCAD therapy were monitored. RESULTS: Pharmacokinetics (PK) of TCAD therapy in healthy volunteers was shown to be similar to the PK of each drug individually from a single dose. In the pilot study, six immunocompromised patients received TCAD therapy and one patient received oseltamivir monotherapy. All but one patient completed 10 days of TCAD therapy without side effects; one patient receiving TCAD was withdrawn from the study because of respiratory failure and ultimately recovered. Viral load was decreased after TCAD therapy despite the presence of either amantadine- or oseltamivir- resistant virus in two cases. One patient with 2009 influenza A/H1N1 receiving oseltamivir monotherapy developed confirmed oseltamivir-resistance during treatment. CONCLUSIONS: TCAD therapy had similar pharmacokinetics to each individual antiviral during monotherapy following a single dose and can be administered safely in immunocompromised patients.Antiviral therapy 12/2012; 18(3). DOI:10.3851/IMP2475 · 3.14 Impact Factor
Top Journals
University of Oxford
Oxford, England, United Kingdom
- Centre for Tropical Medicine
Mahidol University
Krung Thep, Bangkok, Thailand
- Faculty of Tropical Medicine
University of Melbourne
Melbourne, Victoria, Australia
- Department of Biochemistry and Molecular Biology
University of Khartoum
Al Kharţūm, Khartoum State, Sudan
- Faculty of Medicine
Shoklo Malaria Research UnitBranch Amphoe Mē Sōhd, Tak, Thailand
Universidade do Algarve
Фару, Faro, Portugal
- Centre for Molecular and Structural Biomedicine (CBME)
Mahidol Oxford Tropical Medicine Research Unit (MORU)Krung Thep, Bangkok, Thailand
University of California, San Francisco
San Francisco, CA, United States
- Division of Hospital Medicine
National Institute of Health Research and DevelopmentBatavia, Jakarta Raya, Indonesia
Uppsala UniversityUppsala, Uppsala, Sweden
Dalarna UniversityFahlun, Dalarna, Sweden


text: Home > Lifestyle > Teen > Your relationships Your relationships All sections in Teen » Your body » Your future » Your life » Your relationships » Teen News Teens and sex The mere thought that your 14-year-old could be considering having sex is enough to give parents permanent insomnia. So what makes some teenagers decide to go ahead anyway? Ask Teen Expert » Join Heart to Heart » Quiz Will the relationship last? » Test Push-ups » Types of drugs teens use Teens keep cyberbullying alive How to deal with your teen's first love Your love-strung teenager has gone from being your little angel to someone's high-school sweetheart. How best to handle it? Nag, nag, nag – but are your parents right? Eat your vegetables, phone when you are going to be late, early to bed on school nights, do your homework, don't slouch. It is at this point where the glazed look comes in handy. Make nice with mom When it comes to mothers and teen daughters, you can bet there are conflicts about hair, friends and messy bedrooms. How can two people who love each other disagree so much? The beginner's guide to dating boys Need a little help on how to, un-complicate "The Date"? Even if you don't feel quite ready yet for your first date you can tuck this stuff away for later. Get along with your parents Negotiating with your parents to loosen up a little is a skill, so here; we show you how to take the pressure off. Parents driving you crazy? Are there things you can do to reduce the fighting and get them to listen to what you have to say before they bluntly refuse to let you do something you really would like to? " Latest comment on Health24 Christine Barbier says... Greetings you want to buy or sell your kidney, Artemis Hospitals is urgently in need for O+ve and A+ve kidney donors with any passports require. If any one is willing to sell... The dark world of internet kidney trafficking " When young love hurts For one in three teenagers their first love is an introduction to physical, emotional or sexual abuse. Dumped! So what now? There is a big difference between being dumped after ten years or after three days of furious flirting. So how does one deal with being dumped? Is he interested or what? You take a detour between Biology and Maths and walk up three extra flights of stairs, just because you might walk past him on his way to his English class. load more articles advertisement From our sponsors Soothe your family's coughs and colds Why hydration is important while exercising Taking charge of your health Man, take care of your health! Live healthier Up for grabs » Win with NuSeed Win with MySmartkid Win a Canderel hamper Win a LED 3D smart TV Stand a chance of winning a Samsung UA55H8000 Smart 55 inch Curved LED TV valued at R20 000 from Save Hyper! Medical marijuana » 'I used cannabis oil to cure my cancer' Could your doctor could be high? Dagga in medicine? Medicinal dagga: the dangers can't be ignored There is not sufficient evidence to support the potential medicinal benefit from cannabis use cautions an academic from Stellenbosch University.


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English codebreaker, mathematician, biologist, and a founder of computer science, Alan Turing's contributions are responsible for the technology we rely upon and take for granted.
When he was a teen, his teachers and parents criticized him for sloppy handwriting, being unorganized, and only spending time studying math and science. Few appreciated his genius until Turing reached university. At the age of 23, he wrote a paper known as "On Computable Numbers…" which established the concept of the modern computer.
During World War II, Turing played a decisive role in breaking German Enigma codes. He designed a machine, called a bombe, which decoded enigma messages faster than people could. Turing was also responsible for other major advances in codebreaking. Most historians believe that Turing and other codebreakers helped shorten the war by two years.
After the war and up to 1954, Turing focused on artificial intelligence, mathematical biology, and writing the first software programs. He created the Turing Test which is a test to see if a computer can fool an individual into thinking that it is human. If it can, the computer has proven that it is intelligent. He created the first computer chess game, even though at the time there was no computer powerful enough to run the program until years later. His last years focused on morphogenesis or how animals get their spots and stripes, and flowers and cones their patterns. He used computers to help mathematically explain these processes. Sixty years later, his theories were proven correct!
Alan Turing should have lived a long life where he would have made even more discoveries and received the recognition he deserved. Instead, in 1952, he was charged and convicted for 'gross indecency' when the police discovered his affair with his boyfriend. Homosexuality was illegal in Great Britain, as in the United States at this time. Turing's security clearance was withdrawn and he could no longer be a consultant for the British code breaking center. During the trial, Turing insisted that he did nothing wrong and refused to apologize to the court. Since he showed no remorse, the judge made him choose between prison and being a subject in a medical experiment – having weekly injections of estrogen for one year. In order to keep working, Turing choose the injections. Little was known of the side effects of estrogen therapy. It was supposed to decrease male sex drive, but it did not for Turing. Instead, it caused depression, weight gain, impotency, and breast growth. Some of these effects were supposed to be temporary, but in many cases they were not. On June 7, 1954, Alan Turing died of cyanide poisoning at the age of 41. Many believe it was suicide brought about being hounded by British Security, who now saw him as a security threat. Also, the depression brought about by the estrogen injections never went away. Others believe Turing accidently poisoned himself in his home lab and he was known for his sloppy lab work. Yet a few others think he may have been murdered by British Security or the CIA because of the secrets he discovered while he worked for British intelligence. Only one fact is certain, Alan Turing deserved more from the society he protected and enriched with his genius.


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|Reviews for Make Love, Not War
| Puppetshow chapter 1 . 3/12
Oh I bloody loved it,could't stop myself from laughing.
| aalens chapter 1 . 11/18/2014
Hilarious and erotic a great combination. Thank you!
| Animosh chapter 1 . 2/23/2014
God I love this so much! Snack, next to Snarry is my favourite Pairing and this was so brilliant! I laughed so much about this, both Sirius and Severus were hilarious and bottom!Sev is always a plus
| Zugor chapter 1 . 2/16/2014
the most hilarious fanfic i've read in a while!
| Sai121 chapter 1 . 1/6/2014
I don't usually enjoy dialogue bantering when reading these types of stories but you did an awesome job of it. Twas' freaking hilarious to read. Thanks for making me laugh! : )
| Lil Kitsune-chan chapter 1 . 12/6/2013
I loved this. I laughed through out the read and I found them to be mostly in character.
| serenityselena chapter 1 . 11/25/2013
a really entertaining story :)
| Visitkarte chapter 1 . 11/25/2013
I love this. My fingers are itching to translate this... Maybe... I don't know... :D


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29 year old woman | Birmingham, AL, USA | Seeking men 30-34 within 50 miles
Ready for summer....
I am pretty laid back. I am not a jealous person and find jealousy difficult to tolerate. I am trusting and loyal and those two things are very important to me in a relationship. I am quiet but I love to have fun. I am equally happy with dancing the night away or just chilling watching movies. My friends and family are very important to me. Hmmm....I love NASCAR, NFL, MLB and most important Alabama football, Roll Tide!! Because of my parents' profession I have been fortunate to have been able to travel a lot. Traveling has helped make me very well rounded. I have 2 dogs. I am practical and believe in spending money wisely and preparing for the future. Right now school and work have me pretty busy.
Camping , Coffee and conversation , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports
Aerobics, Auto racing / Motorcross, Baseball, Basketball, Billiards / Pool, Bowling, Dancing, Football, Running, Swimming, Walking / Hiking
I exercise 3-4 times per week.
I have Dogs
I like Horses
Jade is a Pomahua. She thinks she is a doberman and definitely thinks she is the boss. I also have Fred a Heinz 57 we found on the side of the road near the lake house.
Middle of the Road
I have traveled a lot US and Europe. Favorite places I have been are Rome, Munich, Athens, Santorini and Turkey. I love to go to Bama Football games and like NASCAR races. 5 points or Lakeview.
Pasta,Color yellow,musical theater, music, my dogs, CSI, Grey's Anatomy, The Hills, American Idol, So You Think You Can Dance, NCIS, riding my jet ski, sweat pants, shoes, NY Yankees, Football, Bama football RTR!!!
I love going to movies, hanging out with friends, traveling, watching sports and playing with my dogs.
Not much of a reader. Mostly I read magazines and right now my nursing school books, not time to read much else.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'0" (152cms)
|5'2" (157cms) to 6'1" (185cms)
|Body type:
|Slender, About average, Athletic and toned
|Black, Blue, Brown, Grey, Green, Hazel
|Dark brown
|Light brown, Dark brown, Blonde
|No Way
|No Way
|Social Drinker
|Social Drinker
|Medical / Dental / Veterinary / Fitness
|No preference
I work in a hospital. I used to teach dance but the hospital and school to be an RN take a lot of time. I dance when I can, but finally had to realize making a living in it wasn't going to work.
|I'll tell you later
|No preference
|Never Married
|No preference
|Have kids:
|Wants kids:
|Latino / Hispanic, White / Caucasian
|White / Caucasian
I was actually born in Honduras and came to the US at 8 months when I was adopted. Unfortunately I haven't learned Spanish yet and my accent is a southern one.
|Christian / Protestant
|Christian / Catholic, Christian / Protestant, Christian / Other
I am a person of very strong faith and grew up in church and church activities. However I am not a fundamentalist and while I am not afraid to share my faith I don't try and force my beliefs on someone else.
|Some college
|High school, Some college, Associates degree, Bachelors degree, Graduate degree
After HS I attended a Fine Arts College in Dance in Florida. Now I am attending Jeff State to be a registered nurse.


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37 year old woman | Indianapolis, IN, USA | Seeking men 32-42 within 60 miles
Active within 1 week
C'mon man!
I have a good life...I love my job, I have great friends, and a great family. I spend a lot of time with my niece and nephews; they light up my life and keep me on my toes! I love to travel and do so as often as I can. I am as comfortable dressed up for a night out on the town as I am in a sweatshirt staying in for the night. I like to hit downtown for a nice dinner, try out a new place, or find a little hole in the wall to hang out and maybe listen to some live music. I have a dry, sarcastic sense of humor and love to laugh! I am a very laid back, fun, giving, thoughtful person. I will go the extra mile and do the "little things" for the people I care about. I am looking for someone to build a life with; someone who makes me smile, laugh, think, and someone who just "gets" me. I want someone who is affectionate, laid back, but not lazy, slow to anger, and just an all around "good" guy. Also looking for a sports fan, anyone, anyone?!
Coffee and conversation , Cooking , Dining out , Hobbies and crafts , Music and concerts , Exploring new areas , Travel/Sightseeing , Watching sports , Wine tasting
Swimming, Walking / Hiking, Weights / Machines
I exercise 1-2 times per week.
I like Dogs
Middle of the Road
Catching some live music, especially outdoors, at the pool, grabbing a glass of wine with dinner, a hole in the wall bar or nice steak house, Colts or Pacers games
University of Evansville, Evansville, IN
I love the beach, sushi, travel, photography...a good day is driving with the windows down and the radio up!
I am usually game for anything...
Home Front
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
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|5'10" (177cms)
|5'10" (177cms) to 8'11" (271cms)
|Body type:
|About average
|No preference
|No preference
|Dark brown
|No preference
|No Way
|No Way, Occasionally
|Social Drinker
|Never, Social Drinker
|Medical / Dental / Veterinary / Fitness
|No preference
|I'll tell you later
|No preference
|Never Married
|Never Married, Widow / Widower, Divorced
|Have kids:
|No preference
|Wants kids:
|Definitely, Someday
|White / Caucasian
|No preference
|Christian / Other
|No preference
|Bachelors degree
|No preference


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IT Services
We provide a digital campus to support the University's staff and students.
News, Events and What's New
Search the IT Services website
News, Events & What's New
Program requirements for teaching in 2015/16
The list of proposed programs for teaching in 2015/16 have been published. Let us know your thoughts on these and other programs you require for next year.
IT courses for Staff & PhD students - places still available
IT Services provide a range of workshops to develop your IT skills and make the most effective use of technology for your work.
Explore the ALICE Supercomputer on one of the regular tours
On this fifteen minute tour you will have the opportunity to find out more about the world class research that has been produced using ALICE.
Microsoft Skype for Business (Lync) available for Corporate Services staff
Corporate Services including staff, externals and Postgraduate Researchers (PGRs) can now install and use Microsoft Skype for Business (previously called Lync).
Update your mobile devices and personal laptop when you change your password
When you change your University IT account password, you should also update the password on any mobile phones, tablets and personal laptops you use.
Have a comment, complaint or suggestion? Let us know
A new online comments, complaints and suggestions form is available so that staff and students can give their feedback about IT.


text: HTC CEO Says the Sexy "Sense" Android Interface Coming to Existing… Dan Nosowitz and 36 othersEditDelete Invite manuallyPromoteXDismissXUndismissBlock for gizmodoHide HTC's been known to slap a polished finish on an existing smartphone OS, first with WinMo's TouchFlo and now Android's Sense. But fret not, HTC G1 and/or Magic/MyTouch owners: HTC's CEO hinted that Sense is coming to existing Android phones. » 6/24/09 10:40pm 6/24/09 10:40pm