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Company Overview of LexisNexis Group Inc.
Company Overview
125 Park Avenue
Suite 2200
New York, NY 10017
United States
Founded in 1973
Key Executives for LexisNexis Group Inc.
LexisNexis Group Inc. Key Developments
LexisNexis Legal & Professional announced the launch of LexisNexis Newsdesk, a comprehensive media aggregation, monitoring and analytics solution enabling business, legal and information professionals to confidently find, analyze and share key insights about the company, industry and competitive environment of their business or client. LexisNexis Newsdesk comes to market as a result of the LexisNexis acquisition of Moreover Technologies last year. Since that transaction, LexisNexis has integrated its collection of licensed news and business information with the deep selection of news, open Web content, and analytical and distribution features from the Moreover Newsdesk solution. These resources are now delivered seamlessly through a single, easy-to-use interface that helps users quickly discover, review and disseminate vital information. Catering to the needs of business strategy, corporate communications, marketing, legal and information professionals as well as other roles seeking current awareness information, LexisNexis Newsdesk offers the most comprehensive collection of global news and business information available. This includes more than four million daily news articles, broadcast media, blogs, and social media channels from more than 150 countries and in 75 languages - all specifically curated and indexed to provide actionable insights quickly. LexisNexis Newsdesk adds value to this rich selection of content with several new capabilities. For example, improved analytics features offer data visualization to create and share market intelligence through live charts and graphs measuring key metrics such as sentiment, share of voice and coverage by geography. Further, a new information panel appears with each search result and displays metadata such as MozRank, Kloutscore and sentiment, enabling a user to quickly determine relevance. And, LexisNexis content has been fully integrated to enable a seamless search experience. Additional capabilities, such as integrated legal content, additional administrative features, and the proprietary LexisNexis SmartIndexing Technology to further enrich content will be added later this year. LexisNexis Newsdesk also offers customization and integration options for a more streamlined workflow. For example, users can build personalized dashboards tailored to their interests or view shared dashboards for collaboration across an organization. It also allows customers to aggregate specified owned and licensed content and directly integrate it into users' workflow. Users also have the option to export relevant news via newsletters, alerts, RSS or ATOM feeds. LexisNexis Newsdesk easily integrates with corporate and law firm portals, intranets and applications such as CRM. It also enables the use of customer branding for a customized look and feel.
LexisNexis Group Inc. Presents at FICO World 2014 Conference, Nov-11-2014 . Venue: San Diego, California, United States. Speakers: Ankush Tewari, Director, Product Management.
Internal Revenue Service, National Office Procurement OS, has awarded a $13,538,297 federal contract to Lexis Nexis on July 1 for 'Electronic Research Services (Award Group 2)'.
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One of the fall books that I'm really looking forward to is Benjamin Moser's biography of Clarice Lispector entitled Why This World, which, according to the back jacket, is "based on previously unknown manuscripts, numerous interviews, and years of research on three continents."
Moser replaced the late John Leonard as the author of Harper's "New Books" column, and is also a contributor to New York Review of Books. (And his mom runs Brazos Bookstore—a future featured indie bookstore.)
Lispector was born in the Ukraine, but grew up in Brazil and wrote all of her works in Portuguese. Most of her books are available from New Directions, including The Hour of the Star, Selected Cronicas, and Soulstorm. (University of Texas did Apple in the Dark a number of years ago, but it's currently out-of-print.)
She was a fascinating writer, and her life sounds equally intriguing. I'm hoping to write a full review of this bio in the not-too-distant future, but here's a bit from the beginning about the mysterious, beautiful Clarice Lispector:
In this void of information a whole mythology sprang up. Reading accounts of her at different points in her life, one can hardly believe they concern the same person. The points of disagreement were not trivial. "Clarice Lispector" was once thought to be a pseudonym, and her original name was not known until after her death. Where exactly she was born and how old she was were also unclear. Her nationality was questioned and the identity of her native language was obscure. One authority will testify that she was right-wing and another will hint that she was a Communist. One will insist that she was a pious Catholic, though she was actually a Jew. Rumor will sometimes have it that she was a lesbian, though at one point rumor also had it that she was, in fact, a man.
What makes this tangle of contradictions so odd is that Clarice Lispector is not a hazy figure known from shreds of antique papyrus. She has been dead hardly thirty years. Many people survive who knew her well. She was prominent virtually from adolescence, her life was extensively documented in the press, and she left behind an extensive correspondence. Still, few great modern artists are quite as fundamentally unfamiliar. How can a person who lived in a large Western city in the middle of the twentieth century, who gave interviews, lived in high-rise apartments, and traveled by air, remain so enigmatic?
Founded in 1960 by such creative pioneers as George Perec, Raymond Queneau and Italo Calvino, the Oulipo, shorthand for Ouvroir de littérature potentielle, came about in when a group of writers and mathematicians sought constraints to find new structures and. . .
There's little to say about a series of prose poems that willfully refuse to identify pronoun antecedents. Or perhaps there are a million things. The poems in Morse, My Deaf Friend— the chapbook by Miloš Djurdjević published by Ugly Duckling. . .
The Crimson Thread of Abandon is the first collection of short fiction available in English by the prolific Japanese writer and all-around avant-garde trickster Terayama Shūji, who died in 1983 at the age of 47. This collection would be important. . .
Last year, NYRB Classics introduced English-language readers to Catalan writer Josep Pla with Peter Bush's translation of The Gray Notebook. In that book, Pla wrote about life in Spain during an influenza outbreak soon after World War I, when. . .
"Your bile is stagnant, you see sorrow in everything, you are drenched in melancholy," my friend the doctor said.
bq. "Isn't melancholy something from previous centuries? Isn't some vaccine against it yet, hasn't medicine taken care of it yet?" I. . .
What to make of Vano and Niko, the English translation of Erlom Akhvlediani's work of the same name, as well as the two other short books that comprise a sort of trilogy? Quick searches will inform the curious reader that. . .
The opening of Jón Gnarr's novel/memoir The Indian is a playful bit of extravagant ego, telling the traditional story of creation, where the "Let there be light!" moment is also the moment of his birth on January 2nd, 1967. Then. . .
Mahasweta Devi is not only one of the most prolific Bengali authors, but she's also an important activist. In fact, for Devi, the two seem to go together. As you can probably tell from the titles, she writes about women. . .
The prolific Spanish author Benito Pérez Galdós wrote his short novel, Tristana, during the closing years of the nineteenth century, a time when very few options were available to women of limited financial means who did not want a husband.. . .
Pedro Zarraluki's The History of Silence (trans. Nick Caistor and Lorenza García) begins with the narrator and his wife, Irene, setting out to write a book about silence, itself called The History of Silence: "This is the story of how. . .

subset: commoncrawl


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Janelle Monáe: The Billboard Women In Music 'Rising Star' Q&A
Billboard Rising Star honoree Janelle Monáe celebrates 'unconventional, universal stories'
This is an excerpt. For the full story, buy this week's issue of Billboard.
When Janelle Monáe graced the cover of Billboard in June, her second album, "The Electric Lady," existed mostly on secret MP3s in the basement of her creative cooperative in Atlanta known as the Wondaland Arts Society. It was closely guarded, but there for the listening if you wanted to kick off your shoes and dance.
In the five months since, "The Electric Lady" has been unleashed into the world with a spark and good will only a feminist "android" like Monáe could muster, led off by instant anthems like the power-funk "Q.U.E.E.N." (featuring Erykah Badu) and the dreamy rubdown "Primetime" (featuring Miguel). The album features additional collaborations with Prince, Solange Knowles and Esperanza Spalding, while Sean "Diddy" Combs and OutKast's Big Boi were co-executive producers.
• Janelle Monae Named Billboard's 'Rising Star'
The album debuted at No. 5 on the Billboard 200, and she's performed its songs on "Saturday Night Live," "The Arsenio Hall Show" and more, all with the signature professionalism, aplomb and enthusiasm she's been flossing since her 2010 debut—an electric lady in her own right.
Recognizing both her critical and commercial acclaim, Monáe will be honored as Billboard's Rising Star of 2013 at the Billboard Women in Music event on Dec. 10 at the Capitale in New York. Monáe will join P!nk, who will be feted with this year's Woman of the Year accolade.
"From her distinctive style to her unexpected collaborations, Janelle is truly carving her own path in this industry," Billboard editorial director Bill Werde says. "We are thrilled to celebrate her talents as this year's Rising Star and look forward to seeing what she does next."
For her fans, "The Electric Lady" has come to serve as a well-considered tome and guiding light for young women to feel good about themselves, no small feat in today's climate, but exactly what she's always set out to do. It's how she can present herself as a fantastical android, but remain one of the more relatable pop icons.
Monáe is a beacon of humility, with a centered confidence, and naturally disinclined to brag. But a top executive at her record company offers praise on her behalf.
"Janelle's a real artist, a beautiful woman with a stunning voice," Atlantic Records Group chairman/COO Julie Greenwald says. "When she's in my office and she sings her voice is so gorgeous. Then she starts to dance right there in my office and you're just drawn in to her world.
"She's a real entertainer, she has it all, she takes risks, and creates great art.
"Janelle wants to make big music that doesn't depend on a sample or loop," Greenwald continues. "She makes an album that you're going to want to put on five to 10 years from now. It doesn't sound like it's part of 2014—it's great music, which she backs up with her performances.
"She's paved the way for women to take a risk, to not to conform and copy the sound of the day. You don't have to mold yourself or conform to any stereotype. She understands she's a role model. Janelle's so positive, humble and appreciative, she's a truly lovely person."
Billboard spoke with Monáe the weekend she opened BET's Black Girls Rock! special, with a performance of "Electric Lady" replete with a dazzling step team celebrating their inherent badass-ness. She was eating carrots, and in good spirits.
We spoke in June, long before your album arrived. In the months since, you've been bestowed with many honors, now including Billboard's Rising Star award. How do you feel about this year?
I just want to first acknowledge how amazing this honor is, and how humbled I am, how unexpected it was. This is just the beginning of my career, and we've worked very hard, and we've built something with Wondaland Arts Society. We've been working very hard to construct this angle, the music in the music industry, and from the perspective of what it means to be a young female artist these days in the music industry.
My journey is continuing. We're not stopping or sitting back and reflecting or saying, "Hey, I've made it, I've arrived." I've acknowledged it, and am acknowledging now, how encouraging it is to be recognized. This year, releasing "The Electric Lady" — which is deeply rooted in community and the female protagonist story of our community—has been such a great joy to be able to tell stories about these women—these unconventional, universal stories that don't get talked about or discussed all the time.
I made sure that "The Electric Lady" had strong themes, so many walks of life. And now going out and performing the songs and looking at young girls in the audience being inspired by the album, to tour and know that these stories are really encouraging young girls—to know that they see themselves in the album, as a part of this movement—it's a sign of success. I feel as though we're continuing to try to be successful and being just that.


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36 year old woman | Miami, FL, USA | Seeking men 34-43 within 50 miles
Active within 3 days
I can be dif.
I am a sweet, kind hearted professional who would like someone special to be my partner in crime, someone mature who knows how to laugh, live and enjoy life. We can spoil each other. I am very health conscience, athletic, and enjoy trying new things. I have old fashion moral values and would only desire a real gentleman who knows how to treat a real lady. I am very laid back and only desires the same in a partner. I've been told I'm difficult but some of the best things in life aren't easy to get but well worth it.
Book club , Camping , Coffee and conversation , Business networking , Cooking , Dining out , Fishing/Hunting , Movies/Videos , Museums and art , Music and concerts , Performing arts , Shopping/Antiques , Travel/Sightseeing , Wine tasting
Aerobics, Dancing, Martial arts, Other types of exercise, Running, Walking / Hiking, Weights / Machines, Yoga
I exercise 3-4 times per week.
I like Dogs
Depends on my mood
Still Deciding
Will tell you later
Gideon Series by Eric Jerome
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'3" (160cms)
|5'9" (175cms) to 8'11" (271cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned
|No preference
|Dark brown
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker
|Political / Govt / Civil Service / Military
|No preference
|I'll tell you later
|$75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married
|Never Married, Widow / Widower, Divorced
|Have kids:
|Yes, and they live at home (1)
|Yes, and they sometimes live at home
|Wants kids:
|Probably not
|No, No, but it's OK if my partner has kids
|Black / African descent
|No preference
|Spiritual but not religious
|Spiritual but not religious
|Bachelors degree
|Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


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04-13-2010 #1
- Join Date
- Sep 2009
- Posts
- 28
How can we implement a CA(certificate authority) in linux(Which distribution better?)
Could you introduce me some references about this topic or share your experiences with me?!
Any help will be highly appreciated.
04-13-2010 #2
The choice of the distribution should not matter too much, as long as it is a general purpose distribution.Debian GNU/Linux -- You know you want it.


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"A.D.: The Bible Continues" Comes Home on Blu-ray and DVD November 3
The Uplifting "A.D.: The Bible Continues" Comes Home on Blu-ray and DVD November 3 From Executive Producers Roma Downey & Mark Burnett The Spectacular 12-part Series Comes Home on Blu-ray™ and DVD November 3! LOS ANGELES, CA (July 8, 2015) –Metro-Goldwyn-Mayer (MGM) and Twentieth Century Fox Home Entertainment bring A.D.: The Bible Continues, the uplifting … Continue reading
"Patterns of Evidence: The Exodus" Releases on DVD and Blu-Ray Aug. 4
"PATTERNS OF EVIDENCE: THE EXODUS" RELEASES ON DVD AND BLU-RAY, AUGUST 4, 2015 THROUGH CAPITOL CHRISTIAN DISTRIBUTION AWARD-WINNING DOCUMENTARY ALSO OFFERS COMPANION BOOK AND ORIGINAL MOTION PICTURE SOUNDTRACK CD "PATTERNS OF EVIDENCE is an engaging, visually pleasing and fascinating piece of film-making, whatever one believes." – Rabbi Adam Jacobs, Huffington Post Los Angeles, Calif. – … Continue reading
"Star Wars Rebels: Complete Season One" on Blu-ray 9/1
A Spark of Rebellion Ignites the Galaxy in Star Wars Rebels: Complete Season One! On Blu-ray™ and DVD September 1, 2015 BURBANK, California, June 26, 2015 –– Star Wars Rebels: Complete Season One delivers all 15 action-packed episodes plus never-before-seen bonus material and cast/crew interviews revealing the magic behind the … Continue reading
Invaluable Partners with Profiles in History to Offer Online Bidding on "Morris Everett, Jr. The Auction, Part I," June 29-30, 2015
Invaluable Partners with Profiles in History to Offer Online Bidding on "Morris Everett, Jr. The Auction, Part I," June 29-30, 2015 The collection of Morris Everett, Jr., amassed over 53 years, features lots from more than 196,000 vintage movie lobby cards, posters and other memorabilia BOSTON–(BUSINESS WIRE)–Invaluable, the world's leading online live auction marketplace, and Profiles in … Continue reading
168 FILM FESTIVAL TO SHOWCASE FILMMAKER SUCCESSES PAST AND PRESENT 10% off tickets available with code "freedom10" BURBANK, CA – The 13th annual 168 Film Festival will unspool at Regal Cinemas Premiere House at LA Live on August 29 and 30, 2015. Film teams from around the globe have created engaging stories based on … Continue reading
WORD FILMS ACQUIRES AWARD-WINNING 'ADRENALINE' FOR DISTRIBUTION International Christian Film Festival winner starring John Schneider set for late summer NASHVILLE, Tenn. – (June 18, 2015) – Word Films proudly announces it has reached a distribution deal with the makers of "Adrenaline," the International Christian Film Festival winner starring John Schneider and written, produced … Continue reading
LightWorx Inks Multi-film Deals With JC Films and CDI
LIGHTWORX ENTERTAINMENT INKS MULTI-PICTURE DEALS WITH JC FILMS AND COLLECTIVE DEVELOPMENT, INC Faith-based Marketing, Development and Distribution Company Also Set to Market Highly Anticipated Theatrical Release "Caged No More" SOURCE: Springboard Entertainment Nashville, TN (June 16, 2015) – Recently-launched film company, LightWorx Entertainment, has signed multi-picture deals with JC Films and Collective Development, Inc. (CDI) … Continue reading
OPEN SEASON: SCARED SILLY coming Spring 2016
OPEN SEASON is Back with a Brand New Comedy Adventure! Sony Pictures Animation Announces OPEN SEASON: SCARED SILLY for Spring 2016 Culver City, CA (June 10, 2015) – Continuing one of its most successful franchises, Sony Pictures Animation today announced the upcoming release of OPEN SEASON: SCARED SILLY, the fourth installment in the titled … Continue reading
"Cinderella" on Blu-ray Combo Pack 9/15
"Believe in Magic" – Claudia Puig, USA Today DISNEY'S BELOVED AND EMPOWERING FAIRYTALE TOLD IN A NEW BEAUTIFUL AND MAGICAL WAY CINDERELLA ON BLU-RAY™ COMBO PACK, DIGITAL HD AND DISNEY MOVIES ANYWHERE on September 15, 2015 Over 12 Minutes of Additional Scenes, Including an Alternate Opening, Plus the "Frozen Fever" Theatrical Short! … Continue reading
"2 Broke Girls: The Complete Fourth Season" – TV's favorite comedic duo is back and more hilarious than ever!
They May Be Poor, But Their Humor Is Rich! 2 BROKE GIRLS: THE COMPLETE FOURTH SEASON Serving You The DVD On August 11, 2015 Contains All 22 Episodes From The Fourth Season Plus Never-Before-Seen Extras BURBANK, CA (June 11, 2015) – TV's favorite comedic duo that manages to turn life's lemons into lemon cupcakes … Continue reading
Blake Lively Stars in Timeless Romance "The Age of Adaline" Arriving on Digital HD August 25 and Blu-ray Combo Pack and DVD September 8
Blake Lively Stars in Timeless Romance The Age of Adaline Arriving on Digital HD August 25 and Blu-ray Combo Pack and DVD September 8 SANTA MONICA, CA (June 15, 2015) – Blake Lively (TV's "Gossip Girl"), Michiel Huisman (HBO's "Game of Thrones") andKathy Baker (Edward Scissorhands) along with Academy Award® nomineeHarrison Ford (Best Actor, Witness, … Continue reading
Inspirational Film for the Whole Family "Where Hope Grows" Arrives on Digital HD on August 11 and Blu-ray, DVD and On Demand August 25
An Inspirational Story For The Whole Family About Finding Redemption Through Faith, Hope And Love Arrives On Digital HD August 11 And Blu-Ray™, DVD And On Demand August 25 Los Angeles, Calif. (June 15, 2015) – Experience the power of faith, courage and friendship when the moving drama Where Hope Grows arrives on Digital … Continue reading
MegaFest Adds Tyler Perry's "Madea On the Run" Play to Line Up
MEGAFEST ADDS TYLER PERRY'S "MADEA ON THE RUN" PLAY TO LINE UP MegaFest Marks Debut of Tyler Perry Production for Dallas Tour Stop DALLAS (JUNE 12, 2015) – MegaFest, the nation's largest inspirational family festival, today announced Tyler Perry's new stage play, "Madea on the Run," will make a tour stop in Dallas during … Continue reading
Spy Comedy "Barely Lethal" Arrives This August For Home Viewing
Spy Comedy Barely Lethal Arrives This August For Home Viewing A teenage undercover agent discovers graduating from high school may be a bigger challenge than being an international spy in the action comedy Barely Lethal, arriving on Blu-ray™ (plus Digital HD) and DVD (plus Digital) August 4th from Lionsgate Home Entertainment. Released theatrically by A24, … Continue reading
Heirs to Madagascar's Royal Throne Are Born: Two New Baby Ring-Tailed Lemurs Named Princess Julien and … Princess Julien
Heirs to Madagascar's Royal Throne Are Born: Two New Baby Ring-Tailed Lemurs Named Princess Julien and … Princess Julien In a Milestone for the Planet's Most Threatened Group of Mammals, the Duke Lemur Center Welcomes Two Baby Ring-Tailed Lemurs – Both Named in Honor of (and Deference to) King Julien XIII DURHAM, … Continue reading


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User talk:Nibblesnbits
Hello, Nibblesnbits, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are some pages that you might find helpful:
- The five pillars of Wikipedia
- How to edit a page
- Help pages
- Tutorial
- How to write a great article
- Manual of Style
I hope you enjoy editing here and being a Wikipedian! Please sign your name on talk pages using four tildes (~~~~); this will automatically produce your name and the date. If you need help, check out Wikipedia:Questions, ask me on my talk page, or place
{{helpme}} on your talk page and someone will show up shortly to answer your questions. Again, welcome! Cheers, TewfikTalk 18:01, 11 August 2006 (UTC)
- 1 Molecular and Cellular Biology Wikiproject Newsletter!
- 2 This month's WP:MCB Article Improvement Drive article
- 3 FA nomination Enzyme inhibitor
- 4 Molecular and Cellular Biology WikiProject Votes
- 5 This month's WP:MCB Article Improvement Drive article
- 6 One more vote for the coordinator of the Molecular and Cellular Biology Wikiproject
- 7 Molecular and Cellular Biology Wikiproject Newsletter
- 8 This month's winner is proteasome!
- 9 This month's winner is RNA interference!
- 10 This month's MCB Collaboration of the Month article is Peripheral membrane protein!
- 11 Louisiana wikipedia users
- 12 Hi there
- 13 Wikipedia Campus Ambassadors wanted at LSU
- 14 Research into the user pages of Wikipedians: Invitation to participate
Molecular and Cellular Biology Wikiproject Newsletter![edit]
We have a new newsletter!
|As you've no doubt noticed, there's a new Molecular and Cellular Biology Wikiproject newsletter, which will be sent out about once a month to all WP:MCB members. This newsletter is designed to perform two equally important functions. Firstly (and obviously, perhaps) it will serve to inform the members of the MCB project of such things as important discussions, votes, and article improvement drives. Secondly, and perhaps more importantly, the periodic correspondance will hopefully encourage a greater level of participation from the MCB community by acting as a gentle reminder of many of the the interesting tasks that are awaiting completion. If you prefer to receive this newsletter in the form of a link, or not receive it at all, you can add your name at Wikipedia:WikiProject Molecular and Cellular Biology/Newsletter/Opt Out List.
New project feature: MCB Article Improvement Drive
|Have any pet MCB subjects that you think need attention? Have you been longing to be part of a team of like-minded editors working toward a common goal? If so, the MCB Article Improvement Drive is for you! On the first of every month a new article is selected by the MCB with the goal of promoting it to good article status. Make your nominations and cast your votes now, because the first article will be chosen on September 1!
Discussion: do we need an MCB director?
|In an effort to organize and motivate the MCB activities, it has recently been proposed that a member of the MCB project take the role of "director", who would be responsible for the administrative side of the MCB project, including but not limited to coordinating recruiting efforts, spamming the newsletter, and maintaining the Article Improvement Drive and MCB Portal. A special discussion/vote page has been created for this proposal, and the vote will run until 23:59, 10 September 2006 (UTC), unless the community decides otherwise.
Odds and ends: what else you got?
If you wish to opt out of having the newsletter posted on your talk page in the future, you may add yourself to the opt out list
Newsletter concept and layout blatantly "borrowed" from the Esperanza newsletter.
This month's WP:MCB Article Improvement Drive article[edit]
|Cell nucleus
The Molecular and Cellular Biology WikiProject's current Collaboration of the Month article is cell nucleus.
– ClockworkSoul 22:53, 4 September 2006 (UTC)
FA nomination Enzyme inhibitor[edit]
Hi there. Since you listed your interests in Mol Biol as including enzyme inhibition, I was wondering if you might have a look at this page and give me some advice and suggestions. Thanks. TimVickers 21:09, 17 September 2006 (UTC)
Molecular and Cellular Biology WikiProject Votes[edit]
|The Molecular and Cellular Biology WikiProject has recently opened two surveys that will help to decide the direction of the project. First, nominations are currently being accepted for the position of coordinator of the project. Second, votes and additional suggestions for the official title of that position are also being taken. As a member of the project, we hope that you'll drop by and voice your opinion. – ClockworkSoul 03:53, 18 September 2006 (UTC)
This month's WP:MCB Article Improvement Drive article[edit]
|Adenosine triphosphate
The Molecular and Cellular Biology WikiProject's current Collaboration of the Month article is adenosine triphosphate.
– ClockworkSoul 21:08, 2 October 2006 (UTC)
One more vote for the coordinator of the Molecular and Cellular Biology Wikiproject[edit]
Since two of the three editors nominated for Coordinator of the MCB Wikiproject declined their nominations, one more vote has been posted: should the remaining nominee, ClockworkSoul, be named as the coordinator, or should nominations be reopened? Every opinion counts, so please vote! – ClockworkSoul 17:50, 17 October 2006 (UTC)
Molecular and Cellular Biology Wikiproject Newsletter[edit]
The project main page has gotten a facelift!
|When people visit the project, the very first thing that they see tends to be the project's main page, and with this in mind, the main page has been completely overhauled. To enhance readability the various "goals" sections have been merged, and a detailed "how you can help" section has been added. To increase accessibility for more established members, the links to any resources that were in the main body text have been moved onto the navigation bar on the right. Finally, the whole page has been nicely laid out and given a nice attractive look.
New project feature: peer review
|I'm proud to announce the addition of out newest feature: peer review! The MCB peer review feature aims serve as a stepping stone to improve articles to featured article status by allowing editors to request the opinions of other members about articles that they might not otherwise see or contribute to.
Project progress
The article worklist
|We've had quite a bit of progress on the worklist article in the past month. Not only has the list itself nearly doubled in size from 143 to 365 entries, but an amazing three articles have been advanced to FA status, thanks in great part to the efforts of our very own TimVickers! Remember, the state of the worklist is the closest thing we have to quantifying the progress of the project, so if you get the chance, please take a look at the list, pick a favorite article, and improve it!
Collaboration of the Month
|Last month's Collaboration of the Month, cell nucleus, was a terrific success! In one month, the article went from a dismal stub to an A-class article. Many thanks to all of the collaborators who contributed, especially ShaiM, who took on the greatest part of the burden. This month's Collaboration of the Month, adenosine triphosphate, isn't getting nearly the attention of its predecessor, so if you can, please lend a hand!
|The project has a new coordinator, ClockworkSoul! The role - my role - of coordinator will be to harmonize the project's common efforts, in part by organizing the various tasks required to make the project run as smoothly and completely as possible. Many thanks to those who supported me and those participated in the selection process.
If you wish to opt out of having the newsletter posted on your talk page in the future, you may add yourself to the opt out list
Newsletter concept and layout blatantly "borrowed" from the Esperanza newsletter.
This month's winner is proteasome![edit]
The Molecular and Cellular Biology WikiProject's current Collaboration of the Month article is proteasome.
– ClockworkSoul 22:13, 1 November 2006 (UTC)
This month's winner is RNA interference![edit]
|RNA interference
The Molecular and Cellular Biology WikiProject's current Collaboration of the Month article is RNA interference.
– ClockworkSoul 14:40, 2 December 2006 (UTC)
This month's MCB Collaboration of the Month article is Peripheral membrane protein![edit]
|Peripheral membrane protein
The Molecular and Cellular Biology WikiProject's current Collaboration of the Month article is Peripheral membrane protein.
– ClockworkSoul 18:56, 14 January 2007 (UTC)
Louisiana wikipedia users[edit]
Hi, my name is Cory, and I'm working on a story for the Advocate about people in Louisiana who create and maintain Wikipedia pages, particularly ones about the area and its inhabitants. If you would be willing to participate in an interview for it, could you reply by e-mail?
Thanks, Cory
Hi there[edit]
Hi, fellow enzymologist! I wondered if you would be OK with me adding you as a contact on the Enzyme, Enzyme Kinetics and Enzyme inhibitor talk page templates. TimVickers 20:22, 21 March 2007 (UTC)
Wikipedia Campus Ambassadors wanted at LSU[edit]
Hi! I'm leaving you this message because you indicated an association with Louisiana State University. The Wikipedia Ambassador Program is currently looking for Campus Ambassadors to help with Wikipedia assignments at LSU, which will be participating in the Public Policy Initiative for the Spring 2011 semester. The role of Campus Ambassadors will be to provide face-to-face training and support for students on Wikipedia-related skills (how to edit articles, how to add references, etc.). This includes doing in-class presentations, running workshops and labs, possibly holding office hours, and in general providing in-person mentorship for students.
Prior Wikipedia skills are not required for the role, as training will be provided for all Campus Ambassadors (although, of course, being an experienced editor is a plus).
If you live near Baton Rouge and you are interested in being a Wikipedia Campus Ambassador, or know someone else from the area who might be, please email me or leave a message on my talk page.--Sage Ross - Online Facilitator, Wikimedia Foundation (talk) 17:04, 6 December 2010 (UTC)
Research into the user pages of Wikipedians: Invitation to participate[edit]
My name is John-Paul and I am a student with the University of Alberta specializing in Communications and Technology.
I would like to include your Wikipedia user page in a study I am doing about how people present themselves online. I am interested in whether people see themselves in different ways, online and offline. One of the things I am looking at is how contributors to Wikipedia present themselves to each other through their user pages. Would you consider letting me include your user page in my study?
With your consent, I will read and analyze your user page, and ask you five short questions about it that will take about ten to fifteen minutes to answer. I am looking at about twenty user pages belonging to twenty different people. I will be looking at all user pages together, looking for common threads in the way people introduce themselves to other Wikipedians.
I hope that my research will help answer questions about how people collaborate, work together, and share knowledge. If you are open to participating in this study, please reply to this message, on your User Talk page or on mine. I will provide you with a complete description of my research, which you can use to decide if you want to participate.
John-Paul Mcvea
University of Alberta
Johnpaulmcvea (talk) 17:43, 17 September 2011 (UTC)


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I am a newbie in IPhone programming.I was sending one of my views screen shot as email.How can i rotate my screen shot image to 270 degree to make it suitable for me ? Any help will be greatly appreciated..
Take the 2-minute tour ×
Stack Overflow is a question and answer site for professional and enthusiast programmers. It's 100% free, no registration required.
Load your image in UIImageview and try.
Open the photo in Preview, find "rotate right"/"rotate left" in the tools menu.
This question would be better asked on supper user -- stack overflow is reserved for programing or near programing questions.


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The filibuster has been used to delay many things over the years: Civil rights, spending bills, presidential nominees and, most recently, Obamacare. But this may be the first time in history that a group of senators filibustered themselves.
About 30 Democratic senators — calling themselves the Senate Climate Action Task Force — kept the Senate open overnight Monday into Tuesday morning. "We're not going to rest until Congress wakes up and acts on the most pressing issue of our time," declared Sen. Brian Schatz of Hawaii, the organizer of the sleepless senators.
Seeking action on global warming is a worthy endeavor, and the night owls deserve praise for the enthusiasm. But burning the midnight oil in this manner is peculiar. Usually, when a lawmaker talks all night, he's trying to stop the majority from passing something. But these people are trying to persuade the majority — themselves — to pass something.
Joining the late-night guerrilla action was Harry Reid, D-Nev., who as the Senate majority leader is usually a target of filibusters, not a sponsor. If he and his colleagues really want action, they don't have to lose sleep. They could bring a climate-change bill to the floor.
The problem is that Reid doesn't have the votes in his caucus to pass such a measure. A year ago, the last time the Senate considered a fee on carbon emissions, 13 Democrats joined with all 45 Republicans in defeating it. Democrats facing difficult re-election fights this year were conspicuously absent from Monday night's lineup.
"I think if we went immediately to a vote, we probably wouldn't be successful," said Sen. Sheldon Whitehouse of Rhode Island, an organizer of the all-nighter.
Reid, who kicked off the 13-hour talkathon at 6:30 p.m., didn't mention the problems among his fellow Democrats. He praised his colleagues for "standing up to the deniers" and "the oil-baron Koch brothers and their allies in Congress."
Apparently, those allies were not intimidated by the Democrats' late-night show. Sen. Jim Inhofe, R-Okla., crashed the party, needling his colleagues for more than half an hour. "All night long? That's going to be fun," said Inhofe, who calls global warming a "hoax" and frequently sights cold snaps as confirmation. "They'll have an audience of themselves and I hope that they enjoy it."
Late-night antics
The participants did seem to enjoy it. They had a Twitter hashtag, #Up4Climate, and gave energetic speeches long and short on the science of climate change. They figured their antics in the wee hours would display their dedication for all Americans to see, or at least insomniacs who watch C-SPAN2. It also might impress Democratic donors. As The Washington Post's Ed O'Keefe reported, Democratic senators discussed plans for the filibuster last month at a fundraiser held by liberal billionaire Thomas Steyer.
"We hope that by (senators) staying up all night to discuss climate change, tomorrow will signal a new dawn of climate-change action in Congress," said Sen. Ed Markey of Massachusetts.
That's a lofty sentiment, but there's no real prospect of the Senate, much less the Republican-controlled House, moving to limit carbon emissions in the next few years. For now, environmentalists are putting their hope inPresident Barack Obama's Climate Action Plan, which includes efforts by the Environmental Protection Agency to limit carbon dioxide emissions from power plants and other polluters.
That's about all that can be done for now, organizers of the all-nighter acknowledged. In fact, the sleepless senators weren't advocating any particular action on climate change. "Tonight is not about a specific legislative proposal," Whitehouse said. "It's about showing the environmental community … that the Senate is starting to stir."
Starting to stir. But it won't awaken with so many Democrats hitting the snooze button.


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San Francisco and Los Angeles, cafes, juiceries, farmers markets, the mission, Hayes Valley, Santa Monica, Los Feliz. Anywhere with sunshine, water and good spicy food. Hawaii, Vancouver, Manhattan, Paris, Spain, Venice, Libya, India, Japan, China
University of California, Los Angeles, Los Angeles, CA
Long Drives, 80s and 90s Music, Moz, The Smiths, Classical Music, Haydn, Mozart, South Park, Curb your Enthusiasm. Adam Curtis documentaries, Economics, Soccer, Tennis, NPR, Humor, Lip balms, Solitude, Meditation, sunshine and rain, together
Meeting new people. Hearing new stories. Helping someone. Traveling. Volunteering and helping little kids learn. Nice massage after long day. Trying new restaurants and ethnic cuisines. Being a foodie. Enjoying glass of wine. Trying something new.
Anything intellectually stimulating. The Economist. The New Yorker.
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Psychology and Economics


text:
Today's Paper, also known as the e-Edition, is an online replica of the
printed newspaper. You can view today's paper or previous issues.
The MFD is not planning on making any changes to its procedures in the wake of a shooting of a firefighter early Monday morning while responding to a medical call, Fire Chief Mark Rohlfing said.
The beer's slogan is "Mild Light and Smooth," but there's nothing mild or light about this cone-top beer can. At more than 40 feet high and boasting a capacity of 2,319,241 ounces, it's the world's largest.
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View more prep sports galleries
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Behind every LeapFrog toy is the promise of a fresh and engaging learning experience that inspires and delights! LeapFrog toys captivate children on an emotional and intellectual level, encouraging interaction and enlightenment at every turn. With LeapFrog's multi-sensory, hands-on approach, children of all ages and learning needs, do more than just play with LeapFrog toys, they learn with them.
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Karina Flores Model
AMADEUSPhotographer Male Honolulu, Hawaii, US
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*I have been contracted to assist a strong contact of mine with looking for talent that is interested in doing Reality footage on a topic that I am truly passionate on. I will often shoot as a stills photographer for the reality shoots, but mostly I will be searching for males and females that have the ability to show a good personality and strong presence in front of the camera. We have worked in several cities and have completed many shoots. Maybe you will be a participant in one of the upcoming ones that is or will be scheduled soon.
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Directions to Gertrude Ederle Recreation Center
Know Before You Go
Gertrude Ederle Recreation Center
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With the intention to modulate gene expression in vascular mural cells of remodeling vessels, we generated and characterized transgenic mouse lines with Cre recombinase under the control of the platelet-derived growth factor receptor-β promoter, referred to as Tg(Pdgfrb-Cre)35Vli. Transgenic mice were crossed with the Gt(ROSA)26Sortm1Sor strain and examined for Cre activation by β-galactosidase activity, which was compared with endogenous Pdgfrb expression. In addition, Pdgfrb-Cre mice were used to drive expression of a conditional myc-tagged Cthrc1 transgene. There was good overlap of β-galactosidase activity with endogenous Pdgfrb immunoreactivity. However, dedifferentiation of vascular mural cells induced by carotid artery ligation revealed a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb promoter driven Cre dependent myc-tagged Cthrc1 transgene expression. Our studies demonstrate the capability of the Pdgfrb-Cre mouse to drive conditional transgene expression as a result of prior Cre mediated recombination in tissues known to express endogenous Pdgfrb. In addition, the study shows that ROSA26 promoter driven reporter mice are not suitable for lineage marking of smooth muscle in remodeling blood vessels.
Blood vessel development is guided by receptor ligand interactions that allow for crosstalk between the endothelial cells and the surrounding mesenchyme. The role of platelet-derived growth factor (Pdgf) in recruiting mural cells during blood vessel formation has been demonstrated through gene targeting of the ligand (Pdgfb) (Hellstrom et al., 1999; Leveen et al., 1994) and the platelet-derived growth factor receptor beta (Pdgfrb) (Soriano, 1994); however, major arteries and the heart appeared to develop normally in Pdgfrb deficient embryos (Soriano, 1994). The dependence of pericyte/smooth muscle cell (SMC) recruitment on Pdgfb/Pdgfrb signaling was shown to be variable between different tissues, with vascular mural cells expressing Pdgfrb in most tissues except liver, as determined by in situ hybridization (Hellstrom et al., 1999).
The expression of Pdgf receptors has been well characterized and the expression of the Pdgfrb has been demonstrated in fibroblasts, kidney mesangium (Alpers et al., 1993; Seifert et al., 1998), myoblasts and muscle lineages (Crosby et al., 1998), smooth muscle (Majesky et al., 1990), pericytes (Lindahl et al., 1999), and neurons (Smits et al., 1991). In the developing embryo, Pdgfrb expression was prominent in the developing mesenchyme and in the developing gastrointestinal tract (Shinbrot et al., 1994).
In mice and rats, endothelial cells are typically the only cell type that is found in the tunica intima of arteries. Various models have been developed to induce intimal thickening in carotid arteries and our laboratory developed and characterized the mouse carotid artery wire denudation (Lindner et al., 1993) as well as the carotid artery ligation model (Kumar and Lindner, 1997). Intimal lesion formation in these models is preceded by dedifferentiation and proliferation of SMC in the media with subsequent migration of proliferating SMC into the intima where they give rise to the neointima (Kumar and Lindner, 1997; Lindner et al., 1993; Reidy et al., 1992). The dedifferentiation of SMC in this process is characterized by a reduction in SMC specific markers such as smooth muscle alpha actin, SM22-alpha, and smooth muscle myosin heavy chain (SM-MHC) (Lindner et al., 1993; Regan et al., 2000).
Pdgf signaling also plays important roles in arteries and in the response to arterial injury by promoting migration of SMC from the media into the developing neointima (Buetow et al., 2003; Ferns et al., 1991; Jackson et al., 1993; Jawien et al., 1992; Majesky et al., 1990). Using the rat balloon injury model we previously demonstrated that the activated and dedifferentiated SMC of the neointima expressed elevated levels of Pdgfrb (Lindner et al., 1995; Lindner and Reidy, 1995). In the present study we describe the generation of transgenic mice using a Pdgfrb promoter fragment to drive Cre expression. Pdgfrb-Cre mice were crossed with Gt(ROSA)26Sortm1Sor reporter mice as well as mice carrying a Cre inducible transgene in order to characterize the sites of prior Cre recombinase activity in embryonic tissues, postnatal tissues and in remodeling arteries.
We generated transgenic mice with Cre recombinase under the control of the Pdgfrb promoter and crossed them to the Cre reporter strain B6;129S4-Gt(ROSA)26Sortm1Sor (Soriano, 1999). In this reporter strain LacZ expression is silent until the transcriptional stop, flanked by LoxP sites, is excised by Cre recombinase (Fig. 1). Tg(Pdgfrb-Cre)35Vli mice were also bred with transgenic mice expressing Cre inducible collagen triple helix repeat containing 1 (Cthrc1) with a myc epitope tag fused to its C-terminus, designated strain name Tg(CagGfp-Cthrc1myc)11Vli. In the absence of Cre recombination this transgenic mouse line expresses GFP under the control of the CAG promoter. Upon Cre recombination, the GFP cassette, flanked by LoxP sites, is removed and Cthrc1-myc is expressed (Fig. 1). This allowed for comparison of β-galactosidase staining and myc tag immunoreactivity localization.
The distribution pattern of β-galactosidase activity in various postnatal tissues seen in the Tg(Pdgfrb-Cre)35Vli/Gt(ROSA)26Sortm1Sor mice was similar to the immunoreactivity of the Cre inducible transgene driven by the Pdgfrb promoter in Tg(Pdgfrb-Cre) 35Vli/Tg(CagGfp-Cthrc1myc)11Vli mice (Fig. 2). Consistent with endogenous Pdgfrb expression, β-galactosidase activity and transgene immunoreactivity were seen in vascular and alimentary tract smooth muscle, kidney mesangium, skeletal muscle, adult myocardium and dermal fibroblasts (Fig. 2). The blood vessels of the liver showed no β-galactosidase activity, transgene expression or Pdgfrb immunoreactivity (not shown). The recombination efficiency in esophageal smooth muscle and skeletal muscle of four adult Tg(Pdgfrb-Cre)35Vli/Gt(ROSA)26Sortm1Sor mice was determined to be 99.5±0.6% and 99±2.0%, respectively (Table 1). In embryonic tissues, β-galactosidase activity was present in the developing dermis, skeletal muscle, mesenchymal condensation/perichondrium, lung tissue, spinal cord/ectoderm, kidney mesangial cells and the myocardium. Serial sections displaying Pdgfrb immunoreactivity showed an analogous staining pattern (Fig. 3).
We analyzed β-galactosidase activity staining on sections of remodeling and normal carotid arteries from Tg(Pdgfrb-Cre)35Vli/Gt(ROSA)26Sortm1Sor mice to assess recombination efficiency in vascular SMC. Activity of β-galactosidase was restricted to medial SMC with no detectable staining observed in the adventitia. The percentage of carotid artery SMC exhibiting β-galactosidase activity in uninjured common carotid arteries was similar for the left and right side (not shown), with a range from 35.5% to 79.0% and an average of 61.9±17.9%. Surprisingly, remodeling carotid arteries responding to ligation revealed very few β-galactosidase positive cells in the neointima (Fig. 4). In addition, the percentage of SMC in the media exhibiting β-galactosidase activity also declined. Quantification of β-galactosidase staining in the ligated (left) and corresponding contralateral (non-injured) carotid artery is shown in Table 2 for five adult mice. The medial SMC and dedifferentiated SMC of the neointima did express endogenous Pdgfrb as well as the Pdgfrb-Cre driven myc-tagged transgene (Fig. 4).
To address the utility of the Gt(ROSA)26Sortm1Sor reporter line for analyzing Cre recombinase activity in remodeling arteries we applied the carotid artery ligation model to B6;129S-Gt(ROSA)26Sor mice with constitutive expression of LacZ under ROSA26 promoter control (Friedrich and Soriano, 1991). β-galactosidase activity localization in these mice also exhibited a significant decrease in the number of β-galactosidase positive SMC in the media as well as in the developing neointima of the remodeling artery (Fig. 4). Quantitative real time reverse transcription PCR (qRT-PCR) data revealed a 21.98 ± 1.56 fold decrease (p=0.00003) in LacZ expression in remodeling carotid arteries when compared to expression in normal carotid arteries (Fig. 5). These findings indicate that the decrease in ROSA26 reporter activity is independent of Cre mediated recombination.
One major reason for developing Pdgfrb-Cre transgenic mice was the high activity of the Pdgfrb promoter in dedifferentiated vascular smooth muscle of remodeling and injured arteries (Lindner and Reidy, 1995; Majesky et al., 1990). While a Pdgfrb-Cre transgenic mouse line has been previously developed by others (Abraham et al., 2008; Foo et al., 2006), a detailed analysis of this mouse line has not been published. The purpose of the study conducted here was to characterize a Pdgfrb-Cre transgenic mouse line with emphasis on vascular smooth muscle and mural cells. The Tg(Pdgfrb-Cre)35Vli/Gt(ROSA) 26Sortm1Sor mice displayed β-galactosidase activity in most medial SMC of the carotid arteries, indicating that these cells were indelibly tagged by Cre recombination. With β-galactosidase now under the control of ROSA26 regulatory elements and the ROSA26 promoter thought to be active in most cells and tissues, we anticipated that SMC forming the neointima would display β-galactosidase activity because they originated from cells in the media (Reidy et al., 1992). The low β-galactosidase activity seen in dedifferentiated SMC was therefore surprising and raised the question whether the ROSA26 reporter is suppressed in dedifferentiated SMC.
Using Gt(ROSA)26Sor mice that have constitutive β-galactosidase activity (in the absence of any prior Cre mediated recombination), we found low β-galactosidase activity levels (Fig. 3) and a significant reduction in LacZ expression (Fig. 5) in dedifferentiated SMC. These data indicated a relative reduction of ROSA26 reporter activity in dedifferentiated SMC. We ruled out the possibility that only LacZ negative cells from the media contributed to neointima formation because SMC undergoing dedifferentiation in the media also lost expression of LacZ (Table 2). We could also rule out a potential discrepancy between LacZ expression and β-galactosidase enzyme activity because remodeling and control tissue specimens were meticulously treated in an identical fashion and because β-galactosidase activity was still detectable in some SMC that had not undergone dedifferentiation within the remodeling artery.
We previously discovered Cthrc1 as a gene expressed in remodeling arteries and we generated a transgenic mouse expressing myc-tagged Cthrc1, Tg(CagGfp-Cthrc1myc)11Vli, in the presence of Cre recombinase (Fig. 1). Using myc-tagged Cthrc1 transgene expression as an alternative readout for prior Cre recombinase activity, we clearly demonstrated that Cre recombination had occurred in the SMC that dedifferentiated in response to carotid artery ligation in Tg(Pdgfrb-Cre) 35Vli/Tg(CagGfp-Cthrc1myc)11Vli double mutant mice. We were not able to directly demonstrate Cre protein expression in remodeling arteries by immunohistochemistry due to the lack of suitable antibodies.
We previously generated transgenic mouse lines that constitutively overexpress Cthrc1 under the control of the CMV promoter (Pyagay et al., 2005). When we crossed two different transgenic mouse lines, we observed brittle bones with reduced collagen matrix deposition (Pyagay et al., 2005). Yamamoto et al. (Yamamoto et al., 2008) as well as Kimura et al. (Kimura et al., 2008) reported that targeted disruption of the Cthrc1 in mice did not result in any developmental abnormalities. Here we used a mutant mouse strain with inducible expression of Cthrc1 following Pdgfrb-Cre mediated recombination. We deliberately chose expression of the myc-tagged Cthrc1 transgene as a readout for prior Cre activity for this study because we anticipated no major developmental abnormalities that would have complicated the interpretation of the transgene expression results. Although not investigated in any detail here, we did not observe any obvious developmental abnormalities in Tg(Pdgfrb-Cre)35Vli/Tg(CagGfp-Cthrc1myc)11Vli double mutant mice. Because Cthrc1 is an efficiently secreted protein and Pdgfrb is a cell surface receptor, the distribution of the immunoreactivity for these two proteins is different at the cellular level.
Our results indicate that the Pdgfrb −4.7/+0.1kb regulatory sequence of the Pdgfrb gene used here drives Cre mediated recombination and subsequent transgene expression in most cell types that express endogenous Pdgfrb. The Tg(Pdgfrb-Cre)35Vli strain should be a useful tool for researchers in various fields including vascular and kidney biology. We also show that the Gt(ROSA)26Sortm1Sor reporter mice are not suitable for cell lineage tracking in blood vessels undergoing remodeling because LacZ expression as well β-galactosidase activity under direct control of the ROSA26 locus are decreased in dedifferentiated SMC. These results may be limited to reporter mice driven by the endogenous ROSA26 promoter and may not apply to more recent ROSA26 reporter strains such as those with the CAG promoter knocked into the ROSA26 locus (Yamamoto et al., 2009). The most likely explanation for these results is that the activity of the ROSA26 promoter is decreased in remodeling vasculature. However, in the absence of any in-depth characterization of the ROSA26 promoter we cannot rule out decreased stability of the LacZ transcript as an alternative explanation.
A −4.7/+0.1 kb fragment of the Pdgfrb promoter including the first exon was amplified from mouse genomic DNA using the forward primer (CGTTGCTTCCTTGATGTTTGCTTGTGA) and the reverse primer (GCTGTCTTCTGTTATTTTGCTGGACCCA). The amplified sequence was fused to a nuclear targeted Cre recombinase sequence.
All studies involving mice were approved by the Institutional Animal Care and Use Committee of the Maine Medical Center Research Institute, which adheres to all applicable federal laws and rules, and the guidelines and recommendations spelled out in the "Guide for Care and Use of Laboratory Animals."
Oocytes from an FVB female mated with a homozygous male of the B6;129S4-GT(ROSA)26Sortm1Sor1 strain (JAX #003309) (Soriano, 1999) were injected with the construct using standard methodologies. Founder animals were identified and crossed to Gt(ROSA)26Sortm1Sor mice to analyze Cre recombinase activity by examining β-galactosidase activity in embryonic tissue (E10.5, E13.5 and E17.5), adult organs and after vascular injury. Three month old animals (n=5) were used in the carotid artery flow cessation model as described (Kumar and Lindner, 1997). The carotid arteries, aortae and organs were harvested 4 weeks later for analysis of β-galactosidase activity.
Cre-inducible transgenic mice expressing myc-tagged Cthrc1, Tg(CagGfp-Cthrc1myc)11Vli, were generated (Fig. 1) and bred with Tg(Pdgfrb-Cre)35Vli mice to obtain double transgenic mice. The myc tag allowed for specific detection of the transgene by immunohistochemistry. Three month old animals (n=5) were used in the carotid artery flow cessation model as described (Kumar and Lindner, 1997). The carotid arteries, aortae and organs were harvested 4 weeks later for anti-myc and Pdgfrb immunohistochemistry.
To assess the utility of the ROSA26 promoter driven reporter mice in remodeling arteries more directly, B6; 129S-Gt(ROSA)26Sor mice (JAX # 002073) (Friedrich and Soriano, 1991) with constitutive expression of LacZ under ROSA26 promoter control were subjected to carotid artery ligation to induce arterial remodeling. The carotid arteries, aortae and hearts were harvested 4 weeks later for histological analysis of β-galactosidase activity or one week later for analysis of LacZ expression.
Frozen sections of carotid arteries, aortae and embryonic tissues (20μm thick) were prepared for β-galactosidase activity localization with nuclear Fast Red counterstain as described (Weiler et al., 2001). Immunohistochemistry for Pdgfrb (Epitomics, Inc., #1469-1, 1:250 dilution) and the myc epitope tag were performed with rabbit monoclonal antibodies on serial sections of paraformaldehyde fixed tissues embedded in paraffin following antigen retrieval with heat in citrate buffer pH=6.0 (LeClair et al., 2007). The myc epitope tag specific rabbit monoclonal antibody (clone Vli-1, 10ng/ml dilution) was raised against a synthetic peptide derived from the human c-myc proto-oncogene (EQKLISEEDL). Adjacent sections were also stained without a primary antibody to serve as negative immunohistochemistry controls.
Image analysis was used to quantify β-galactosidase activity on cross-sections of aortae and ligated as well as contralateral carotid arteries as previously described (LeClair et al., 2007). These measurements were also used to assess recombination efficiency. In all cases, recombination efficiency was similar in left and right common carotid arteries from unmanipulated mice. The percentage of medial and neointimal area exhibiting blue β-galactosidase staining in the remodeling artery was determined and expressed as a percentage of the blue area determined for the non-ligated carotid artery. Recombination efficiency for esophageal smooth muscle and skeletal muscle was determined by quantifying the percentage of muscle tissue showing β-galactosidase activity in tissue sections from four adult mice.
Levels of LacZ transcript in remodeling and normal carotid arteries from Gt(ROSA)26Sor mice with constitutive expression of LacZ under ROSA26 promoter control were compared by isolating RNA from remodeling (left) and normal (right) carotid arteries (n=7). cDNA was prepared by reverse transcription and transcript levels were determined using qRT-PCR with glyceraldehyde-3-phosphate dehydrogenase (Gapdh) as a reference gene. qRT-PCR was performed on the Bio-Rad iQ5 cycler using the iQ-SYBR Green Supermix (Bio-Rad). Primers amplifying LacZ (GGTAAACTGGCTCGGATTAGGG and GCTGATGTTGAACTGGAAGTCGC) and mGAPDH (ATCACTGCCACCCAGAAGACTG and ATCCACGACGGACACATTGG) were used. A non-template control was included for all qRT-PCR reactions. All samples were run in triplicate. The thermal profile was 95°C for 10 min, 40 cycles of 95°C for 15 sec and 58°C for 1 min. Samples were normalized with respect to Gapdh and expression levels in the remodeling carotid arteries were expressed as a fold change relative to the normal carotid arteries using the comparative Ct method (ΔΔCt = ΔCt sample − ΔCt reference).
Supported by NIH Grants HL69182 (V.L.) and P20 RR-15555 from the National Center for Research Resources. The Histopathology Core Facility is supported by P20RR181789 (Director Dr. Don Wojchowski). The Mouse Transgenic Core was supported by P20 RR-15555 (Director Dr. Robert E. Friesel).
The authors thank Anne Harrington for her services related to transgenic animal generation and Kathleen Carrier for excellent histology services.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Keeping Holocaust Stories Alive: As More Survivors Pass Away, New Ways to Remember Are Found
For decades, men and women have visited classrooms to give firsthand accounts of the systematic elimination of Europe's Jews. As survivors, they were the exception, because far more perished than made it out alive. Stories from eyewitnesses to the Holocaust have been seen as the best way to help students understand how a civilized, educated society could collaborate as 6 million Jews were murdered.
That is coming to an end. People who were teenagers when the war began in 1939 are now in their 80s. So educators are looking for new ways to reach students before the Holocaust becomes just one historical event.
"We are going to lose the reservoir" of living experience, said Michael Berenbaum, a founder of the U.S. Holocaust Memorial Museum and a past president of the Shoah Foundation, an organization that preserves survivors' testimonies. "Despite all of the power in establishing memory, there's a fragility to it, because it depends on a certain generation of men and women."...
...Of course, the basic demographic shift applies equally to veterans of World War II, whose ranks at Veterans Day celebrations diminish every year. But Holocaust education has always placed special emphasis on individual stories, with advocates arguing that abstract facts and numbers alone don't do justice to the memories of those who died. For decades, groups such as the Yale Fortunoff Video Archive and the Shoah Foundation have worked to film survivors' testimony for posterity. Those videos aren't going anywhere. But time is ticking on the interactions between survivors and students...
One group is taking a wholly different approach. The Peabody, Mass.-based Holocaust Legacy Partners project is asking volunteers to sign contracts committing themselves to getting to know a survivor now so that they can tell their story later."No less than twice each year," the materials state."You will represent their memory by providing firsthand eyewitness testimony to current and to future generations." About 35 people have signed up so far, said Sonia Weitz, a survivor and the head of the program.
Another group is turning to the children and grandchildren of survivors. Facing History and Ourselves, a Brookline, Mass.-based education organization that has worked with Holocaust survivors for more than 30 years, recently started meeting with the children and grandchildren of survivors to talk about how to tell their stories in classrooms. That approach is controversial, with some wondering whether the younger generation's own experience is what needs to be retold.
Even if advocates disagree on how to respond to the shift taking place, most agree that some response is necessary...
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David Hastings - 8/13/2009
All history is in the past. All historical personages, perpetrators and victims fade into the mist of history.
This, quite frankly, seems a determined effort of a small minority in the US to remain in a "victim" role.
One would think the U.S.A. had been the regime that instituted the WWII-era "Holocaust" by the sounds of it: why should American school children be inundated by this history? Why should the country that gave lives to stop this horror PAY for museums and force this historical "remembrance" upon our children?
How many innocent civilians perished during WWII should be the focus: ALL war is horror, ALL war is hell.
We now have confessed proof that some of these "Holocaust Victims" made their tales out of whole cloth, like the woman claiming to have been "raised by wolves" after "escaping" a Concentration Camp. This is just one example, and I see no reason to subject American schoolchildren to possible myths.
Genocides, regrettably, have occurred through the eons, and are ongoing today.
In point of fact, we now (Sibel Edmond's Deposition, 8/8/09) have credible testimony that the Turkish government blackmailed sitting US Representatives to hide and deny the Armenian Genocide.
Are those WWI-era victims of the Armenian Genocide by the "Young Turks" LESS of a victim than the Jews of Nazi Germany? Are the present-day Palestinians LESS of a victim?
Are we going to spend hundreds of millions to not let those fade from memory? Will we build Armenian Genocide Museums?
Both of the above Genocides, as well as others (some stated quite clearly in the Old Testament, btw) should get as much focus as the Nazi Genocide of Jews: a passing reference to the horrors committed by man against man.
This article demonstrates an unacceptable preference, and is of questionable value.
- The Memorial Where Slavery Is Real
- Thomas Piketty accuses Germany of forgetting history as it lectures Greece
- Greek 'No' May Have Its Roots in Heroic Myths and Real Resistance
- 150 years later, schools are still a battlefield for interpreting Civil War
- Where are America's memorials to pain of slavery, black resistance?
- Historian: "I don't want my students to simply choose sides in a polemic between heritage and hate"
- Harvard's Nancy Cott says the conservatives in the gay marriage case have a stilted idea of the history of marriage
- Did a historian who said he's a victim of McCarthyism get the story wrong?
- Stephanie Coontz's work on the history of marriage cited by the Supreme Court.
- How Does It Feel To Have One's Work as a Historian Cited by the Supreme Court? Cool. Very Cool. Thank You Very Much.


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Meredith Tangen '08, '10 MBA, recognized by the Iowa Association for Career and Technical Education.
Rev. Charles Nigawaba '09 MEA built a school in his native Ugandan village
Martin Coe '84, '92 MBA, '13 DBA teaches accounting at Western Illinois University.
While pursuing her SAU Master of Social Work degree, Miracle Leach '14 serves as in-house manager for homeless families
Jim Collins' commitment to enhancing diversity has made a large impact at his alma mater
Matt Ehlman '02 will use award to build a template for nonprofit fundraising
Martha Garcia Tappa '91 found a release from cancer by sharing stories of fellow survivors.
A new industry award for the Emmy-winning costume designer "whose work has gone beyond mere beginner's promise."
Steve Roell '71 shared lessons of a career that led to the CEO chair at Johnson Controls Inc.
Alumni are producing a reality show for NHL team's website
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
Feel the Bix Beat at the Alumni House!
Gather with fellow Ambrosians at the Bix 7 finish line.
Join St. Ambrose alumni and friends for a great day of golf.


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28 year old man | Astoria, NY, USA | Seeking women 25-32 within 15 miles of New York, NY
Something you should read.
What's going on?! Some facts: 55% introvert, 45% extrovert. Try to seamlessly navigate between seriousness and spontaneity. I wouldn't hesitate to swat a fly out of the sky, but think keeping a fish in a fish tank is somewhat limiting to the poor animal. I spend a lot of time thinking about who's cooler: The Dos Equis guy or James Bond. Know the capitals of most countries. Stay cool through MTA service disruptions. Distinguished at both work and play. Have a healthy interest in the Eastern school of thought and apply it to my professional and personal life. I like thinking of my own Zen proverbs from time to time, like: He who smelt it probably dealt it. Like assembling IKEA furniture. Wonder how and why the Kardashians generate so much air time. About me: Work as an accounting manager and am pursuing law school. What I'm looking for: meeting someone interesting, fun, kind and challenging and seeing where things go. What I'm not looking for: If the bulk of your pictures are poses struck in a dark bar setting and you moved to NYC with some absurd fantasy of becoming a hipster. Admit it, you enjoyed reading my profile!!
Coffee and conversation , Dining out , Gardening/Landscaping , Hobbies and crafts , Movies/Videos , Music and concerts , Exploring new areas , Playing sports , Shopping/Antiques , Travel/Sightseeing , Video games , Watching sports
Aerobics, Baseball, Basketball, Bowling, Cycling, Dancing, Football, Martial arts, Other types of exercise, Skiing, Walking / Hiking, Weights / Machines, Yoga
I exercise 3-4 times per week.
I like Birds, Cats, Dogs, Fish, Horses
When I've got more time on my hands, I'd like to have a Beagle and name him after some historical military leader. We'd be inseparable and unstoppable. :) How does Charlemagne the Beagle sound?
Some other viewpoint
New York is my favorite hot spot. I loved Amsterdam when I visited because any city you can walk across in two hours or bike around is cool in my book.
My friends and family mean the world to me.
Long sprints on a distant beach and bear hugging the occasional tiger are right up my alley.
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|What he is looking for
|6'0" (182cms)
|5'1" (154cms) to 6'0" (182cms)
|Body type:
|Athletic and toned
|Slender, Athletic and toned, Full-figured, A few extra pounds
|Black, Blue, Brown, Grey, Green, Hazel
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Dark blonde
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|Never Married
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|Have kids:
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I'm actually from Krypton.
|Agnostic, Atheist, Buddhist / Taoist, Spiritual but not religious, Other
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|Bachelors degree
|Some college, Bachelors degree, Graduate degree
I'm currently studying for LSAT.


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Physical Therapy
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Our post-professional programs enable physical therapists to be leaders in their practice, their profession, and their communities.
Health Policy & Practice Management Faculty Institute
Friday, Aug. 14 – Saturday, Aug. 15, 2015, in King of Prussia, PA. Gain real-life expertise in choosing content and designing teaching and learning activities in the areas of health policy and practice management.
Our Research
Our faculty research areas include skeletal muscles, neurologic injuries, shoulder and knee movement, running biometrics and athletic performance, and the effects of exercise on Parkinson's Disease.
Upcoming Events
Physical Therapy Information Session
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Arcadia DPT has won Honorable Mention in the 14-2015 Miami–Marquette Challenge #DPTstudent #physicaltherapy t.co/pCcRK5QBgd
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Healthy runners needed for a research study at Arcadia... -Need to be between 30-55 years old. -Injury-free for the previous year. -Time com [...]
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Does Exchange Fragmentation Really Hurt the Equity Market?
In today's commentary, RegOne's David Weisberger looks back at the "good old days" when there were two exchanges. He said this setup was not necessarily that good and, despite the fear of the unknown, technology and venue competition generally lead to progress.
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Trillion-Dollar Stock Managers See Chaos on Greek No Vote
July 6, 2015 – Equity managers overseeing more than $3.7 trillion said the game of chicken between Greek Prime Minister Alexis Tsipras and creditors threatens lasting damage to a European stock rally that earlier in 2015 added as much as $2.17 trillion to share prices.
Surge in Europe Stock Options Volume Shows Race to Hedge Greece
July 6, 2015 – Whatever happened after Greeces vote, stock investors had time to prepare beforehand.
HKEx to Resume Closing Auction, Impose Temporary Price Limits
July 6, 2015 – Hong Kong Exchanges & Clearing Ltd. will reintroduce a daily auction to set closing stock prices and impose temporary price controls to limit extreme share moves.
Three Seconds Has Become an Eternity in the Chinese Stock Market
July 6, 2015 – For international investors accustomed to speed, trading in Chinas stock market is like flying blind.
Active ETFs Gain in Canada as Challenge to High-Fee Mutual Funds
July 2, 2015 – Actively managed exchange-traded funds are surging in Canada, posing a challenge to the mutual-fund industry that has the highest management fees in the world.
Chinese Stocks Rise as Regulators Move to Stem Losses
July 2, 2015 – Chinese stocks rose after securities regulators relaxed margin-trading rules and cut equity- transaction fees in their latest attempts to prevent the countrys slide into a bear-market from deepening.
India Might Seek to Curb HFT and Algorithmic Trading
July 2, 2015 – The market regulator for India's equity markets is close to hopping on the anti-high-frequency trading bandwagon and seeking market controls to curb their activity. Regulations could also be in the wings for algorithmic trading as well.
Nasdaq Joins BATS Global in Push for Equity Market Pricing Changes
July 2, 2015 – Echoing a tune the was sung recently by BATS Global, exchange operator NasdaqOMX is also now publicly advocating for changes to the way equity prices are determined.
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Deutsche Asset & Wealth Management's Mike Bellaro Overhauled His Trading Desk. Here's How.
Bellaro's mission was clear - update his trading desk, deploy new technology and beat the competition. Traders gets an inside look at just how he did this and how it might help make DB bigger than Goldman Sachs.
An Inside Look at Luminex, the ATS Built By the Buyside
With Luminex, a collection of elite asset managers is creating a new buyside trading venue that is not-for-profit.
Celebs Hit the BTIG Trading Floor For Charity
Global brokerage firm BTIG raised more than $5 million for its Commissions from Charity Day 2015 thanks to Kristin Davis, Eli Manning, Hannah Storm, Lawrence Taylor, and other celebs.
After 45 years on Wall Street, Bank of Americas Sylvia Rocco Retires
Bank of America Merrill Lynch's senior trader and managing director Sylvia Rocco has finally decided, after more than four decades on the trading desk and floor, to leave the firm and the only job she has ever known.
Dark Pool Dilemma - Aggregation Aggravation
In this final "Tales from the Dark Side," Greenwich's Craig Viani examines how venue proliferation has driven the need for algo aggregation, and brought to light the challenges in accessing non-displayed liquidity via an intermediary.
SEC Set to Begin Debate on Order Protection Rule on May 13
The first meeting of the Securities and Exchange Commission's newly formed equity market structure committee, set for next month, will focus on the so-called "order protection rule."
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VTI UF Series 29" Fixed Height Speaker Stand
VTI UF Series 29" Fixed Height Speaker Stand
Weights & Dimensions
|Material: Metal
|Powder Coated Finish: Yes
|Adjustable Height: No
|Cable Management: Yes
|Stabilizer Feet: Yes
|Isolation Spikes: Yes
|Limited Speaker Compatibility: Yes
|Weight Capacity: 100 Pounds
|Number of Items Included: 2
|Sold as a Pair: Yes
|Country of Manufacture: China
About the ManufacturerVTI Manufacturing, Inc. specializes in manufacturing metal and wood furniture for home and office use. Their goal is to provide their customers with the best quality products, very affordable prices and excellent service. Their products are divided into two main categories: Commercial & Residential. VTI commercial lines mainly include metal TV carts, computer tables, book / tape trucks and easels for use in offices, schools, computer labs, libraries, showrooms, churches and training centers, etc.
All products are constructed with durable solid steel, designed for easy mobility and flexibility, and finished smoothly and beautifully. All units are equipped with long cord electric outlets and are readily assembled. VTI residential lines mainly include audio / video racks and speaker stands for home theatre use. All the audio racks are constructed with steel frame and tempered glass or MDF shelves.
VTI racks offer deeper and taller shelving space to accommodate the most-up-to date electronic equipment. Both the stackable and fixed racks give you the most beautiful display of your equipment matching with your furniture at home. VTI speaker stands, on the other hand, are all metal construction with cast iron base. This special feature not only offers flexible and beautiful design, but also stability and sturdiness. The rapid development of technology is changing our world. VTI, as a manufacturer, is also constantly updating their design and products to accommodate the changes.
VTI UF Series 29" Fixed Height Speaker Stand
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Pairs Great with my Studio 00's
Luke from Mechanicsville, VA – Verified Buyer
Got these to pair with Paradigm Studio 20's instead of the J29's that retail for $500. 30 minutes worth a drill work to line up matching screw holes and I got an equal stand for 1/4 of the price. Looks great and much more reasonably priced. Well worth it.
OUR SKU # VI1171UF Series 29" Fixed Height Speaker Stand is also sometimes listed under the following manufacturer numbers: UF29B, UF29S