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Publications (93)221.22 Total impact
- SourceAvailable from: Uwe Lendeckel[Show abstract] [Hide abstract]
ABSTRACT: ADAM 12 (meltrin alpha) belongs to a large family of molecules, consisting of members with both disintegrin and metalloproteinase properties. ADAMs have been implicated in several cell physiological processes including cell adhesion, cell fusion, proteolysis and signalling. ADAM 12 is widely expressed, including skeletal muscle, testis, bone, intestine, heart and kidney. In addition, a variety of tumours show elevated expression of ADAM12; among them being breast-, colon-, gastric- and lung-carcinoma. As to the brain, ADAM 12 has been shown previously to be expressed in rat and human oligodendrocytes. However, little is known about the expression of this protease in brain tumours. This study demonstrates the presence of ADAM 12 in non-neoplastic oligodendroglial cells of normal human brain as well as in neoplastic oligodendroglia and minigemistocytes arising from four pure oligodendrogliomas and three mixed oligoastrocytomas. Double stainings revealed a notable preference of ADAM 12 for the oligodendroglial over astroglial components. The results of immunohistochemistry are in accordance with the results obtained from the RT-PCR, which further demonstrated a mild difference concerning the mRNA concentration of ADAM 12 between similar grades of eight astrocytomas and eight oligodendrogliomas (namely four astrocytomas grade II versus four oligodendrogliomas grade II and four astrocytomas grade III versus four oligodendrogliomas grade III). Both cellular immunostaining for ADAM 12 and ADAM 12 mRNA content decrease with higher histologic grade of the tumour. Surprisingly, the latter parameter (ADAM12 mRNA) showed a significant opposite correlation to the degree of histologic tumour malignancy. From our data showing that ADAM 12 is highly expressed in, but not restricted to, oligodendrogliomas, we conclude that ADAM 12 immunohistochemistry may be a helpful tool in the diagnosis of brain tumours.Disease markers 01/2013; 34(2). DOI:10.3233/DMA-120953 · 2.17 Impact Factor
Article: Klinische und radiologische Analyse tödlicher intensivmedizinischer Verläufe nach schwerem Schädel-Hirn-Trauma[Show abstract] [Hide abstract]
ABSTRACT: Für Patienten mit einem nach schwerem Schädel-Hirn-Trauma (SHT) tödlichen Verlauf gelten folgende Todesursachen als häufig: die supratentorielle Herniation, der diffuse axonale Hirnschaden und extrazerebrale Komplikationen. Diese seit Jahrzehnten anerkannten Daten basieren auf autoptischen Untersuchungen bei noch am Unfallort Verstorbenen. Gegenstand dieser prospektiven Studie sind Todesfälle nach SHT im intensivmedizinischen Verlauf: Bei 30Patienten einer Intensivstation, die nach SHT verstarben, wies eine zu Lebzeiten, innerhalb von 8Tagen nach Unfall durchgeführte Kernspintomographie (MRT) in 26Fällen (87%) eine Hirnstammläsion nach. Diese war vermutlich zu etwa 50% primärtraumatischer Genese. Patienten, die bis zum Tode bewusstlos blieben, wiesen immer (und signifikant häufiger als Patienten, die zwischenzeitlich erwachten) Hirnstammläsionen auf, überwiegend eine beidseitige Ponsläsion. Betroffene, die intermediär vor dem Exitus aus dem Koma erwachten, wiesen zu 71% eine Hirnstammläsion auf. In dieser Gruppe war die Komadauer im Falle des Vorliegens eines Hirnstammschadens signifikant verlängert. Die traumatische Hirnstammläsion ist nach unseren Ergebnissen ein in Frequenz und Pathogenese entscheidender Faktor für das Versterben nach SHT auf der Intensivstation; 50% dieser Läsionen scheinen primärtraumatischer Genese zu sein. Die Beurteilung der Hirnstammveränderungen mittels MRT erlauben grundlegende Aussagen über den zum Tode führenden klinischen Verlauf. The following causes of death are suspected to be most frequent in patients with severe head trauma and fatal ending while in intensive care: supratentorial herniation, diffuse axonal injury, and extra-cerebral complications. Brainstem lesions caused by primary trauma are assumed to be seldom. Their impact in life-threatening courses is not thought to be statistically relevant. This study describes 30 patients with severe head trauma in intensive care who died. Within the first 8 days, an MRI was performed, which showed lesions within the brainstem in 26 cases (87%). In up to 50% of the cases, these brainstem lesions could be traced back to a primary trauma by clinical appearance or radiological findings. In patients who never regained consciousness, the MRI always showed a brainstem lesion. In most cases, there was a bilateral lesion within the pons. In patients who regained consciousness before dying, MRI showed brainstem lesions in 71 %. In this group, the duration of coma was significantly longer in the presence of a brainstem lesion. Loss of cortical answer in somato-sensible and early acoustic-evoked potentials correlates significantly with the evidence of brainstem lesions. It seems that the appearance of brainstem lesions represents a major factor associated with death after severe head trauma. Furthermore, 50% of these lesions are caused by the initial injury impact and are not due to herniation. Analyzing brainstem lesions on MRI allows prediction about life-threatening course after severe head trauma.Intensivmedizin + Notfallmedizin 01/2010; 47(1):59-64. DOI:10.1007/s00390-009-0045-0
Article: Clinical and radiological analysis of fatal courses in severe brain injuries during intensive care treatment
Article: Transcripts of PTTG and growth factors bFGF and IGF-1 are correlated in pituitary adenomas.[Show abstract] [Hide abstract]
ABSTRACT: The reasons for the increase of pituitary tumor-transforming gene (PTTG) transcripts in about 90% of pituitary adenomas are still not fully understood, although upregulation by basic fibroblast growth factor (bFGF) has been discussed as a potential cause. A possible influence of the Insulin like Growth Factor 1 (IGF-1) might be of interest, since this protein is also synthesized in most pituitary adenomas. Moreover, the principal regulation of the PTTG gene by IGF-1 and Insulin has been demonstrated in astrocytoma and breast cancer cells. We analyzed a large group (103 patients) of unselected clinical pituitary adenoma samples. From total RNA of frozen tumor samples (all subtypes) cDNA ( COMPLEMENTARY DNA) was synthesized and transcripts of PTTG, bFGF, IGF-1 were measured by Real-Time-PCR. Not only mRNA ( MESSENGER RNA) levels of bFGF, but also of IGF-1, correlated strongly with PTTG transcripts. This result was obtained, when all pituitary adenoma samples were included in the statistical calculations, irrespective of their subclassification. Our study suggests a connection between PTTG and IGF-1 in pituitary adenomas.Experimental and Clinical Endocrinology & Diabetes 06/2009; 118(2):121-6. DOI:10.1055/s-0029-1215588 · 1.76 Impact Factor
Article: Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma.[Show abstract] [Hide abstract]
ABSTRACT: Expression of the transforming growth factor-beta (TGF-beta) protein family in the peripheral nervous system is well established, but the role of their cognate receptors TGF-beta receptor type 1 (R1) and type 2 (R2) has been less well studied. TGF-beta plays an essential role in Schwann cell proliferation and differentiation, and is involved in neurotrophic effects of several neurotrophic substances. TGF-beta is also expressed in benign peripheral nervous system tumors such as vestibular schwannomas. In the present study, we aimed to detect TGF-beta R1 and R2 in a total of 40 sporadic vestibular schwannomas using immunohistochemistry, and correlated the findings to essential clinicopathologic data. TGF-beta, TGF-beta R1, and TGF-beta R2 mRNA was further analyzed by RT-PCR in six vestibular schwannomas. TGF-beta R1 immunoexpression was found in about 95% of the tumors. TGF-beta R1 was equally present in Antoni A and Antoni B areas of the tumors. TGF-beta R2 was found immunohistochemically in 77%. In addition, all tumors showed strong expression of TGF-beta. No correlation between TGF-beta R1 or R2 expression and clinicopathologic parameters such as age, sex, clinical symptoms, growth pattern, and proliferation acitivity as measured by Ki-67 (MIB-1) staining was found. Moreover, all schwannomas studied contained TGF-beta, TGF-beta R1, and TGF-beta R2 mRNA. Therefore, the TGF-beta/TGF-beta R1 and -R2 system is present in human schwannomas, but its biologic role for tumor development and growth remains unclear.Pathology - Research and Practice 02/2007; 203(4):245-9. DOI:10.1016/j.prp.2006.12.007 · 1.56 Impact Factor
Article: Analysis of a single nucleotide polymorphism in codon 388 of the FGFR4 gene in malignant gliomas.[Show abstract] [Hide abstract]
ABSTRACT: The FGFR4 codon 388 polymorphism (Arg(388), Arg/Gly(388) or Gly(388)) was determined in glioblastoma multiforme (GBM), anaplastic astrocytomas (AA), diffuse astrocytomas (DA), and control muscles. Arg(388) was rare in AA, GBM, muscles, and was absent in DA. The Arg/Gly(388) and the Gly(388) frequency was equal among GBM and controls. FGFR4 expression was not related to codon 388 in GBM, and no survival differences between Arg/Gly(388) and Gly(388) tumors were found. U87 cells (Arg/Gly(388)) did not show higher invasion than U138 cells (Gly(388)). This suggests that the FGFR4 codon 388 status does not play a major role in malignant gliomas.Cancer Letters 09/2006; 239(2):239-45. DOI:10.1016/j.canlet.2005.08.013 · 5.02 Impact Factor
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ABSTRACT: The transmembrane tyrosine-specific protein kinase TrkB has been shown to serve as a receptor for the neurotrophic factors BDNF and NT-4. Neurotrophin binding to TrkB isoformes mediates many intracellular signaling pathways, including calcium signalling. Two truncated isoforms of the receptor, lacking the tyrosine kinase activity, signal through a yet unknown pathway. Specific signals modulate the surface expression of TrkB, which is localized in considerable amounts in intracellular pools. These intracellular pools has not been specified so far. We therefore investigated the intracellular distribution of TrkB by colocalisation studies. In contrast to the unspecific neurotrophin receptor NGFRp75, TrkB immunohistochemistry showed a staining pattern very similar to mitochondrial stainings in adult human skeletal muscle fibers. Immunofluorescence techniques revealed in different types of permeabilized cells that TrkB is bound to mitochondrial membranes. This observation was confirmed on isolated astrocyte mitoplasts. Colocalisation of the TrkB ligand NT-4 and the specific mitochondrial marker cytochrome c oxidase was also observed. Western blot analysis of isolated mitochondria from rat brain and skeletal muscle verified that a truncated isoform of TrkB is present in both, brain and muscle mitochondria, and full-length TrkB is additionally present in brain mitochondria. Our results imply that neurotrophins can be stored in mitochondria and possibly act as signalling molecules on mitochondria.The International Journal of Biochemistry & Cell Biology 02/2006; 38(4):610-20. DOI:10.1016/j.biocel.2005.10.024 · 4.24 Impact Factor
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ABSTRACT: Although somatostatin receptors have been detected in many normal and neoplastic tissues, little is known of their expression and function in peripheral nerve tumors. In the present study, we examined the expression of all 5 somatostatin receptor subtypes (sst1-5) in 3 normal peripheral nerves, 3 traumatic neuromas, 27 schwannomas, 18 neurofibromas, and 177 malignant peripheral nerve sheath tumors (MPNSTs) by immunohistochemistry as well as by Western blot and reverse transcriptase-polymerase chain reaction investigations in 2 normal peripheral nerves, one neurofibroma, 5 schwannomas, and 5 MPNSTs. Immunoreactive somatostatin receptors were not detectable in normal peripheral nerve and in nonneoplastic Schwann cell proliferations. In contrast, sst2A mRNA and protein was present in 89% of schwannomas. This receptor subtype was less frequently detected in neurofibromas (22%) and MPNSTs (15%). Interestingly, sst4 was seen in 32% of MPNSTs and was almost exclusively expressed in this malignant tumor type. In support of a role in Schwann cell tumor growth control by somatostatin was the observation of induced internalization of sst2A and inhibition of cell proliferation in an NF1-associated MPNST cell line. Moreover, administration of an sst2A-selective agonist resulted in induction of MPNST cell apoptosis. We conclude that peripheral nerve sheath tumors often express at least one functional somatostatin receptor. Furthermore, our findings suggest a potential clinical role for somatostatin receptor agonists in tumor imaging and/or treatment of schwannomas and MPNSTs.Journal of Neuropathology and Experimental Neurology 01/2006; 64(12):1080-8. DOI:10.1097/01.jnen.0000190065.36182.25 · 4.37 Impact Factor
Article: Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas[Show abstract] [Hide abstract]
ABSTRACT: Activation of intracellular signaling cascades has been implicated in the growth control of benign meningiomas, but their role for meningioma progression and outcome is unknown. Here we determined the expression and function of proteins involved in mitogen-activated protein kinase (MAPK) and phosphinositol-3 kinase (PI3K)/Akt signaling in benign, atypical, and malignant meningiomas and studied their association with clinicopathologic data including meningioma recurrence. Expression of various MAPK and PI3K signaling proteins was determined in 70 primary meningiomas and, if present, in recurrent tumors by immunohistochemistry and Western blotting. The expression patterns in primary and recurrent tumors were related to clinical data. The effect of MAPK and PI3K pathway inhibition on cell proliferation and apoptosis was determined using a primary malignant meningioma cell culture. Atypical and malignant meningiomas showed higher levels of phospho-Akt compared with benign tumors, and their proliferation could be inhibited by PI3K blocking using wortmannin. PI3K inhibition did not induce apoptosis in malignant meningioma cells. In contrast, expression of phospho-Raf and phospho-MAPK was decreased in aggressive meningiomas compared with benign tumors, but MAPK inhibition by PD98059 resulted in tumor cell apoptosis and decreased proliferation. Reduced MAPK activation was associated with meningioma recurrence, and PI3K activation was associated with poor preclinical condition and brain invasion of malignant meningiomas. Both MAPK and PI3K/Akt pathways are activated at different levels in benign and malignant meningiomas. Activation of PI3K/Akt signaling contributes to the aggressive behavior of malignant meningiomas, whereas MAPK activation is involved in both proliferation and apoptosis of malignant meningiomas.Clinical Cancer Research 07/2005; 11(11):4074-82. DOI:10.1158/1078-0432.CCR-04-2550 · 8.19 Impact Factor
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ABSTRACT: A heterogeneous group of multisystem disorders affecting various tissues and often including neuromuscular symptoms is caused by mutations of the mitochondrial genome, which codes 13 polypeptides of oxidative phosphorylation (OXPHOS) complexes and 22 tRNA genes needed for their translation. Since the link between OXPHOS dysfunction and clinical phenotype remains enigmatic in many diseases, a possible role of enhanced apoptosis is discussed besides bioenergetic crisis of affected cells. We analyzed the proapoptotic impact of the mitochondrial 5kb common deletion (CD), affecting five tRNA genes, in transmitochondrial cybrid cell lines and found a slightly enhanced sensitivity to exogenous oxidative stress (H2O2) and a pronounced sensitization against death receptor stimulation (TRAIL) at a rather low CD heteroplasmy level of 22%. Mitochondrial deletions confer enhanced susceptibility against proapoptotic signals to proliferating cells, which might explain the elimination of deletions from hematopoietic stem cells.Biochemical and Biophysical Research Communications 07/2005; 332(1):43-9. DOI:10.1016/j.bbrc.2005.04.086 · 2.28 Impact Factor
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ABSTRACT: Gliomatosis cerebri (GC) is a rare brain tumor characterized by widespread infiltration of large parts of the brain and sometimes even the spinal cord. To determine the cause of this extraordinary degree of brain invasion, we studied immunoexpression of factors associated with brain infiltration in low-grade and high-grade tumor samples from nine GC cases. We further determined the allelic status of the fibroblastic growth factor receptor 4 (FGFR4) gene at position 388 (arginine [Arg(388)] or glycine [Gly(388)]) in eighteen GC patients, because the presence of at least one Arg(388) allele has been suggested to favor tumor cell motility compared to tumor cells homozygeous for the Gly(388) allele. Immunohistochemical analyses showed that tumor samples from three GC cases expressed Tenascin-C, whereas six cases had CD44 - immunopositive tumor samples. Expression of MMP-9 was not observed in any of the nine GC patients. FGFR4 genotyping revealed the presence of the Arg(388) in 72% of the eighteen GC cases, a frequency similar to the one found in 21 common astrocytomas (71%). In tumor-free control DNA, the Arg(388) phenotype was present in 60%. These data indicate that CD44 expression might be related to the tumor infiltration in GC, and that patients suffering from GC or other common astrocytomas do not have a significantly increased frequency of the tumor cell motility-favoring Arg(388) FGFR4 allele.Journal of Neuro-Oncology 07/2005; 73(2):109-15. DOI:10.1007/s11060-004-4206-5 · 2.79 Impact Factor
Article: Regulation of the pituitary tumor transforming gene by insulin-like-growth factor-I and insulin differs between malignant and non-neoplastic astrocytes.[Show abstract] [Hide abstract]
ABSTRACT: The reasons for overexpression of the oncogene pituitary tumor transforming gene (PTTG) in tumors are still not fully understood. A possible influence of the insulin-like growth factor I (Igf-I) may be of interest, since enhanced Igf-I signalling was reported in various human tumors. We examined the influence of Igf-I and insulin on PTTG expression in human astrocytoma cells in comparison to proliferating non-neoplastic rat embryonal astrocytes. PTTG mRNA expression and protein levels were increased in malignant astrocytes treated with Igf-I or insulin, whereas in rat embryonic astrocytes PTTG expression and protein levels increased only when cells were exposed to Igf-I. Enhanced transcription did not occur after treatment with inhibitors of phosphoinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK), blocking the two basic signalling pathways of Igf-I and insulin. In addition to this transcriptional regulation, both kinases directly bind to PTTG, suggesting a second regulatory route by phosphorylation. However, the interaction of endogenous PTTG with MAPK and PI3K, as well as PTTG phosphorylation were independent from Igf-I or insulin. The latter results were also found in human testis, which contains high PTTG levels as well as in nonneoplastic astrocytes. This suggest, that PI3K and MAPK signalling is involved in PTTG regulation not only in malignant astrocytomas but also in non-tumorous cells.Biochemical and Biophysical Research Communications 06/2005; 331(1):86-92. DOI:10.1016/j.bbrc.2005.03.124 · 2.28 Impact Factor
Article: Gastric adenocarcinoma with leptomeningeal carcinomatosis as the presenting manifestation: an autopsy case report[Show abstract] [Hide abstract]
ABSTRACT: Leptomeningeal carcinomatosis is a clinically important and severe complication in patients with cancer. Leptomeningeal involvement as a secondary event in gastric carcinoma is rarely reported and usually occurs late in advanced disease. Herein, we report a case of leptomeningeal carcinomatosis as the initial manifestation of a previously asymptomatic gastric adenocarcinoma. The clinical features and the appropriate diagnostic procedures are discussed.European Journal of Gastroenterology & Hepatology 06/2005; 17(5):577-9. DOI:10.1097/00042737-200505000-00016 · 2.15 Impact Factor
Article: Re-evaluation of the dysfunction of mitochondrial respiratory chain in skeletal muscle of patients with Parkinson's disease.[Show abstract] [Hide abstract]
ABSTRACT: The origin and tissue distribution of the mitochondrial dysfunction in Parkinson's disease (PD) remains still a matter of controversy. To re-evaluate a probably free radical-born, generalized mitochondrial impairment in PD, we applied optimized enzymatic assays, high resolution oxygraphic measurements of permeabilized muscle fibers, and application of metabolic control analysis to skeletal muscle samples of 19 PD patients and 36 age-matched controls. We detected decreased activities of respiratory chain complexes I and IV being accompanied by increased flux control coefficients of complexes I and IV on oxygen consumption of muscle fibers. We further investigated if randomly distributed point mutations in two discrete regions of the mitochondrial DNA are increased in PD muscle, and if they could contribute to the mitochondrial impairment. Our data confirm the previously debated presence of a mild mitochondrial defect in skeletal muscle of patients with PD which is accompanied with an about 1.5 to 2-fold increase of point mutated mtDNA.Journal of Neural Transmission 05/2005; 112(4):499-518. DOI:10.1007/s00702-004-0195-y · 2.87 Impact Factor
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ABSTRACT: Gliomatosis cerebri (GC) is regarded as a rare glial neoplasm of unknown origin, and a detailed analysis of molecular alterations underlying this disease has started only recently. However, because GC characteristically affects large parts of the brain and spinal cord, the distribution of genetic alterations may be highly variable between different tumor areas. Additionally, tumor areas with varying degrees of differentiation may be present, raising the possibility to model the genetic events associated with astrocytoma progression. Here we analyzed various tumor regions with features of low-grade and high-grade astrocytomas from 9 autopsy-proven GC cases for the immunoexpression of the cell cycle-controlling proteins mdm2, p21, p27/kip1, p16, and Rb. The samples were also screened for EGFR expression, and for amplification of the EGFR and MDM2 genes. Furthermore, allelic losses of the CDKN2A gene and of a PTEN flanking region of chromosome 10 were determined. We detected tumor regions with immunoexpression of p21 only rarely in our series, without association to the tumor grade. No MDM2 gene amplification was detected. In contrast, three cases demonstrated maintained Rb expression. The expression of p27(kip1) showed a clear reduction with increasing astrocytoma malignancy in 7 cases. Allelic loss of the CDKN2A gene occurred in 5 patients but was not related to the tumor grading, nor to the intensity of p16 immunoexpression. No homozygous CDKN2Adeletions were detected. EGFR amplification was also absent in our series, but one case demonstrated EGFR expression only in the high-grade tumor area. Allelic losses on chromosome 10 were found in one out of six informative cases. However, marked differences in the immunoexpression, as well as in the distribution of genetic aberrations were seen between different tumor samples within a given case. The distribution of the alterations suggests that these molecular genetic changes represent secondary events, which may develop within tumor clones derived from a common founder tumor clone characterized by extraordinary spreading through the brain. Moreover, the detected aberrations in gliomatosis cerebri can reflect the tumor progression associated with secondary malignant astrocytoma formation even within a single case.Journal of Neuro-Oncology 05/2005; 72(2):115-22. DOI:10.1007/s11060-004-2061-z · 2.79 Impact Factor
Article: Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton[Show abstract] [Hide abstract]
ABSTRACT: The purpose of this study was to investigate the potential effects of 2-methoxyestradiol, a natural mammalian steroid, in glioma cells, since antiproliferative effects of this compound had been shown earlier in several leukemia and carcinoma cell lines. The effects of 0.2, 2 and 20 microM concentrations of 2-methoxyestradiol were measured in three malignant human glioma cell lines (U87MG, U138MG, LN405) and one malignant rat glioma cell line (RG-2) using a microtiter-tetrazolium (MTT) assay. In all cell lines, a significant reduction of the viable cell number by more then 75% occurred ( P < 0.05) for concentrations of 2 and 20 microM 2-methoxyestradiol after 6 days. A concentration of 0.2 microM had smaller effects (10-40% cell reduction), which were significant in two of the cell lines tested. The apoptotic nature of cell death was further analyzed in U87MG and RG-2 cells. Caspase-3 activity was significantly induced to levels between 3.4- and 23-fold after 4 days for the two higher 2-methoxyestradiol concentrations (P < 0.05). In the cell line RG-2 nuclear fragmentation was visible in many nuclei, following stains with Hoechst H33258. A round cell morphology occurred in most treated cells, which was not accompanied by a complete destruction of the microtubule network, as it can be observed with other microtubule targeting drugs.Journal of Neuro-Oncology 03/2005; 72(1):11-6. DOI:10.1007/s11060-004-2158-4 · 2.79 Impact Factor
Article: Short incubation with 2-methoxyestradiol kills malignant glioma cells independent of death receptor 5 upregulation.[Show abstract] [Hide abstract]
ABSTRACT: We investigated the effects of 2-methoxyestradiol (2-ME), a promising new antitumor agent, on viable cell number and nuclear morphology of malignant glioma cells (three human and one rat glioma cell lines) and analyzed the controversial role of death recepor 5 (DR5) upregulation in 2-ME induced apoptosis. Microtiter-tetrazolium (MTT) assays showed a significant reduction of viable cells after incubation with 2 microM and 20 microM 2-ME for 48 and 72 hours in all cultures. In the 20 microM concentration, there were even significant effects in the majority of shorter incubation periods. Hoechst 33258 stains showed a substantial amount of cells with nuclear fragmentation indicating a late stage of apoptosis after 20 microM 2-ME treatments of 24 hours and more. The role of the DR5-mediated extrinsic apoptotic pathway was further studied in the three human glioma cell lines; 50 ng/ml of the DR5 ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and 2 microM 2-ME showed no synergism, as determined by MTT assays. Real-time PCR revealed no significantly increased amount of DR5 mRNA, suggesting that receptor upregulation does not play a major role for 2-ME-induced apoptosis in glioma cells, in contrast to data for a breast cancer cell line in the literature.Clinical neuropathology 01/2005; 24(4):175-83. · 1.31 Impact Factor
Article: Ein epileptologischer ProblemfallAktuelle Neurologie 12/2004; 31(10):504-508. DOI:10.1055/s-2004-828305 · 0.32 Impact Factor
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ABSTRACT: June 2004: Over the past year, this man in late-60s had complained about progressive weakness of concentration and memory disturbances, associated with word finding difficulties. MRI examination revealed an extra-axial, parasagittal tumor 3 cm in diameter located in the left frontoparietal region. Five years ago, a meningioma in the same region, with radiographic appearance comparable to the present tumor had been totally removed. The histological picture of the current tumor was dominated by sheets of large rounded pleomorphic tumor cells with abundant eosinophilic cytoplasm and eccentric nuclei (rhabdoid cells). Cytoplasmic inclusions were frequent; occasionally,multinucleatedtumorcellswereseen. Mitoticfigures were absent and the MIB was 3%. Meningothelial lobules were scarce, and regions with fibroblastic appearance were absent. There were no psammoma bodies, necrosis or brain invasion. Moderate immunoreactivity for EMA was found. Additionally, strong cytoplasmic immunoreaction for vimentin within the rhabdoid cells was observed. Review of the previous material showed small islets of rhabdoid cells. Rhabdoid meningioma is an uncommon meningioma variant. It has been suggested that rhabdoid meningiomas are highly aggressive tumors (WHO grade III)and that the rhabdoid phenotype represents a marker of malignant transformation in meningiomas. Histologically, rhabdoid meningiomas usually exhibit signs of anaplasia, a high mitotic activity, and a markedly increased MIB-1 labeling index. Extracranial metastases may occur in the course of the disease. However, not all rhabdoid tumors appear to have anaplastic features (as this case illustrates). Another interesting feature of rhabdoid meningiomas is that in a significant number of cases, the rhabdoid cells appear only at the time of recurrence. Alternatively, as seen in this case, the rhabdoid cells may be already present in the primary meningioma, but not as the predominating histological feature.Brain Pathology 11/2004; 14(4):457-9. · 4.35 Impact Factor
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ABSTRACT: There are only sparse data on viral CNS infections in patients with malignant glioma. We report a case of fatal herpes encephalitis in a patient with glioblastoma in partial remission and provide a short review of the literature.Clinical Neurology and Neurosurgery 10/2004; 106(4):335-6. DOI:10.1016/j.clineuro.2003.12.002 · 1.25 Impact Factor
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Otto-von-Guericke-Universität Magdeburg
Magdeburg, Saxony-Anhalt, Germany
- Institute for Neuropathology
University Hospital MagdeburgMagdeburg, Saxony-Anhalt, Germany


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The 'Partner exploitation and violence in teenage intimate relationships' research by the NSPCC and Bristol University provides us with an interesting (and alarming) glimpse at 'standardised relational pair' categories (Sacks, 1992) and the moral accountability attached to them (Jayussi, 1984). Sacks' work on categories and their deployment found that certain categories go together like 'boyfriend–girlfriend'. Members of these categories which form 'standardised relational pairs' have rights, responsibilities and duties to each other. In our example 'boyfriend–girlfriend', it is presumed that each person should provide a safe, supportive, caring and respectful relationship environment for each other to grow and develop. It follows then that category pairs and associated predicates (rights, responsibilities etc) are relational in the sense that one may be expected to follow the next with accountability as a moral-procedural requirement. Breaches between these categories and predicates 'one in six said they had been pressured into sexual intercourse and 1 in 16 said they had been raped', tend to generate moral outrage/alarm and interactional repair solutions 'parents and schools can perform a vital role in teaching them about loving and safe relationships, and what to do if they are suffering from violence or abuse'.
Teen girls abused by boyfriends warns NSPCC
Gender-Based Violence
Objectification Theory and Psychology of Women: A Decade of Advances and Future Directions
A tutorial on membership categorization
Social Psychology Eye
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Most Popular Titles With Cris Collinsworth
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1. The Tonight Show with Jay Leno (1992– )
TV-14 | 62 min | Comedy, Music, Talk-Show
After Johnny Carson's retirement from the show, Jay Leno stepped in as his permanent replacement. The format of the show has remained largely unchanged, consisting primarily of an opening ... See full summary »
Stars: Jay Leno, Kevin Eubanks, Edd Hall, Rickey Minor
Votes: 7,882
2. Entertainment Tonight (1981– )
30 min | News
"Entertainment Tonight" is the #1 syndicated entertainment newsmagazine in the world. Launched in 1981, ET is anchored by Mary Hart and Bob Goen. Primary substitute anchors are Jann Carl ... See full summary »
Creator: Alfred Masini | Stars: Mark Steines, Nancy O'Dell, Kevin Frazier, Mary Hart
Votes: 1,313
3. Mike & Mike (2005– )
240 min | News, Sport, Talk-Show
Mike Golic and Mike Greenberg debate sports.
Stars: Mike Golic, Mike Greenberg, Buster Olney, Kristen Balboni
Votes: 409
4. NFL Monday Night Football (1970– )
Coverage of professional football featuring teams from the National Football League airing on Monday nights during the NFL's regular season.
Stars: Frank Gifford, Al Michaels, Dan Dierdorf, Howard Cosell
Votes: 769
5. The Jay Leno Show (2009–2010)
TV-14 | 60 min | Comedy, Talk-Show
Stars: Jay Leno, Kevin Eubanks, Mikey Day, Ross Mathews
Votes: 1,742
6. Pardon the Interruption (2001– )
30 min | Sport, Talk-Show
Two former sportswriters discuss the day's top stories of the sports world.
Stars: Tony Reali, Michael Wilbon, Tony Kornheiser, Dan Le Batard
Votes: 1,161
7. Super Bowl XXXIX (2005 TV Movie)
The 39th renewal of the AFC-NFC World Championship Game pitted the New England Patriots, two-time defending champions, against the Philidelphia Eagles, who hadn't won a championship of any ... See full summary »
Director: Bob Levy | Stars: Rabih Abdullah, Keith Adams, Troy Aikman, David Akers
Votes: 302
8. Rome Is Burning (2003– )
Sport, Talk-Show
Superstar sports journalist Jim Rome hosts the biggest stars in the sporting world on this weekly ESPN talk show.
Stars: Jim Rome, Tom Friend, Roger Lodge, Eric Neel
Votes: 252
9. Super Bowl XLIX (2015 TV Movie)
The defending Super Bowl 48 champions Seattle Seahawks and the AFC champion New England Patriots play for the championship of the National Football League at University of Phoenix Stadium in Glendale, Arizona.
Director: Drew Esocoff | Stars: Paul Allen, Cliff Avril, Bill Belichick, LeGarrette Blount
Votes: 117
10. The NFL on CBS (1956– )
Stars: Al Del Greco, Roman Gabriel, Bart Starr, Tom Landry
Votes: 240
11. The NFL on NBC (1965–1997)
Stars: Joe Namath, Daryle Lamonica, Bob Griese, Don Shula
Votes: 118
12. NBC Sunday Night Football (2006– )
Professional football games played on Sunday night.
Stars: Ben Roethlisberger, Heath Miller, Rodney Harrison, Hines Ward
Votes: 532
13. Inside the NFL (1977– )
60 min | News, Sport
Stars: Cris Collinsworth, Phil Simms, Warren Sapp, Jenn Brown
Votes: 197
14. Madden NFL 2010 (2009 Video Game)
E | Sport
Stars: John Madden, Neil Brown Jr., Tom Hammond, Cris Collinsworth
Votes: 97
15. NFL Films Presents (1967– )
Documentary, Sport
Stars: Steve Sabol, Peter King, Steve Mariucci, Jim Mora Jr.
Votes: 67
16. Vancouver 2010: XXI Olympic Winter Games (2010 TV Mini-Series)
Family, Sport
U.S. coverage of the Winter Olympics in Vancouver.
Stars: Hilary Knight, Bryan Adams, Joe Biden, Justin Bieber
Votes: 224
17. Fox NFL Sunday (1994– )
Sport, Talk-Show
Stars: Terry Bradshaw, Howie Long, Jimmy Johnson, Rob Riggle
Votes: 252
18. NFL on FOX (1994– )
Stars: Jim Mora Jr., Andy McCollum, Steve Mariucci, Gary Anderson
Votes: 255
19. NFL Thursday Night Football (2006– )
180 min | Sport
Professional coverage of NFL games Thursdays night during the season.
Stars: Heath Miller, Ben Roethlisberger, Ike Taylor, Dick LeBeau
Votes: 245
20. Guinness World Records: Primetime (1998– )
A TV version of the popular book collecting the extremes of nature and human endeavors. Hosts Chris Collinsworth and Mark Thompson present a weekly look at the biggest, smallest, fastest ... See full summary »
Stars: Daniel Browning Smith, Mark Thompson, Cris Collinsworth, Tim Cridland
Votes: 26
21. Madden NFL 2009 (2008 Video Game)
E | Sport
Stars: Cris Collinsworth, Tom Hammond, John Madden, Al Michaels
Votes: 84
22. Super Bowl XLVI (2012 TV Movie)
The NFC champion New York Giants and the AFC champion New England Patriots meet for the championship of the National Football League.
Director: Drew Esocoff | Stars: Tom Brady, Rob Gronkowski, Al Michaels, Chad Johnson
Votes: 176
23. Inside the Vault (2011– )
Stars: Jill Wagner, Alonzo Bodden, Cris Collinsworth
24. Super Bowl XXIII (1989 TV Movie)
Director: Ted Nathanson | Stars: Jim Anderson, Leo Barker, Harris Barton, Lewis Billups
Votes: 50
25. Super Bowl XVI (1982 TV Movie)
Director: Neal Marshad | Stars: Charles Alexander, Ken Anderson, Dan Audick, John Ayers
Votes: 37
26. Costas Now (2005– )
60 min | Sport, Talk-Show
Stars: Bob Costas, Armen Keteyian, John McEnroe, Charles Barkley
Votes: 29
27. Madden NFL 11 (2010 Video Game)
E | Sport
Stars: Gus Johnson, Cris Collinsworth, Dean Napolitano
Votes: 99
28. Big Game XXIX: Bugs vs. Daffy (2001 TV Movie)
Writers: Dave Drabik, Chris 'Casper' Kelly | Stars: Nick Buoniconti, Cris Collinsworth, Len Dawson, Jerry Glanville
Votes: 8
29. Big Game XXVIII: Road Runner vs. Coyote (2000 TV Movie)
100 min
Writers: Craig Gordon, Steve Patrick | Stars: Len Dawson, Cris Collinsworth, Nick Buoniconti, Jerry Glanville
Votes: 17
30. 2014 NFL Pro Bowl (2014 TV Movie)
Stars: Grace Potter, Fall Out Boy, Al Michaels, Doug Flutie
31. 1997 AFC Championship Game (1998 TV Movie)
Stars: Dick Enberg, Phil Simms, Paul Maguire, Jim Gray
32. 2009 NFL Pro Bowl (2009 TV Movie)
Stars: David Archuleta, Tiki Barber, Cris Collinsworth, James Farrior
33. 1981 NFL Draft (1981 TV Movie)
Stars: Bob Ley, Chris Berman, Dave Ahrens, Robert Alexander
34. NFL Characters Unite (2012)
44 min | Documentary, Reality-TV, Sport
NFL Characters Unite features Atlanta Falcons' Pro Bowl Tight End Tony Gonzalez, New Orleans Saints' star Tight End Jimmy Graham, Pittsburgh Steelers Wide Receiver and Super Bowl XL MVP ... See full summary »
Director: Greg Frith | Stars: Cris Collinsworth, Tony Dungy, Tony Gonzalez, Jimmy Graham
35. 1988 AFC Championship Game (1989 TV Special)
Stars: Dick Enberg, Merlin Olsen, Paul Maguire, Bob Costas
36. 1981 AFC Championship Game (1982 TV Special)
Stars: Dick Enberg, Merlin Olsen, Pete Axthelm, Mike Adamle
37. The Record Breakers of Sports (1990 TV Movie)
Writer: Steven Stern | Star: Cris Collinsworth
38. 2013 NFL Pro Bowl (2013 TV Movie)
Stars: Al Michaels, Doug Flutie, Michele Tafoya, Cris Collinsworth
Votes: 5
39. Wimbledon '99 (1999 TV Mini-Series)
Stars: Cris Collinsworth, Billie Jean King, Jim Lampley, Larry Merchant
40. Wimbledon '94 (1994 TV Mini-Series)
Stars: Cris Collinsworth, Billie Jean King, Jim Lampley, John Lloyd
41. 1996 AFC Championship Game (1997 TV Special)
Stars: Dick Enberg, Phil Simms, Paul Maguire, Jim Gray
Votes: 6
42. Wimbledon '97 (1997 TV Mini-Series)
Stars: Cris Collinsworth, Jim Lampley
NBC Sunday Night Football (2006– )
2008 Kickoff Game: Washington Redskins at New York Giants
Stars: Jay Alford, Tiki Barber, Jerome Bettis, Ladell Betts
NBC Sunday Night Football (2006– )
2009 Kickoff Game: Tennessee Titans at Pittsburgh Steelers
Stars: Apl.de.Ap, Tyrone Carter, Ryan Clark, Cris Collinsworth
NBC Sunday Night Football (2006– )
2010 Kickoff Game: Minnesota Vikings at New Orleans Saints
Stars: Cris Collinsworth, Brett Favre, Al Michaels
The NFL on CBS (1956– )
Atlanta Falcons vs. Cincinnati Bengals
Stars: Charles Alexander, Jim Breech, Cris Collinsworth, Boomer Esiason
The NFL on NBC (1965–1997)
Buffalo Bills vs. Cincinnati Bengals
Stars: Charles Alexander, Ken Anderson, Jon Borchardt, Jim Breech
NFL Monday Night Football (1970– )
Cincinnati Bengals vs. Miami Dolphins
Stars: Frank Gifford, Howard Cosell, Don Meredith, O.J. Simpson
The NFL on NBC (1965–1997)
Cincinnati Bengals vs. New York Jets
Stars: Charles Alexander, Dan Alexander, Ken Anderson, Marion Barber
NFL Monday Night Football (1970– )
Cincinnati Bengals vs. Pittsburgh Steelers
Stars: Frank Gifford, O.J. Simpson, Joe Namath, Walter Abercrombie


text:
Even if your child's routine involves brushing and flossing twice a day, dental sealants still offer benefits.
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Angie's Answers
If you chose to go the other way, some Prosthodontists will place and restore the implants themselves. In other cases, an Oral Surgeon or Periodontist will place the implant and a Prosthodontist or General Dentist restores it. Fees can vary quite a bit from office to office and with the different options for restorative materials. Some offer free consultations, for others, they charge a fee that might be applied to any future treatment in some cases.
The first step is to schedule a few consultations with different providers, which it sounds like you've already done.
The most important factors when deciding which practitioner to work with:
.1. You should feel comfortable asking your doctor any questions so that you have a good understanding of the procedure itself, healing time and long-terem outcome, and possible complications. Write down a list of questions and take them with you to the consultation.
2. Ask about the experience of the practitioner. How many similiar procedures have they completed? Have they had any major complications with any cases? Ask to see photos if possible.
3..Figure out if it works out better for your schedule, to go to a "one stop" provider or to separate providers for the placement and the restoration of the implants.
4. Follow your instincts. If you feel rushed, didn't get direct answers to your questions, didn't communicate well or had any other negative feelings, this probably isn't the doctor for you.
5. Consider insurance coverage and financing options. If your dental plan covers implants and it is important to you to use a preferred provider, you will want to check your list. Many times, insurance does not cover implants, or at least not all of the steps. You may want to inquire about payment and financing options.
I hope this at least helps you feel a little less confused and a little more directed. Please don't hesitate to contact me if I can be of further help.
Beth L. Gehring,DDS, PC
816 NW Vesper
Blue Springs, Mo 64015
At any point in the process, did they have you sign something saying you were happy with the denture set up? Some practitioners will document the patient's acceptance at the try-in appointment, before the denture is processed. At that time, changes in tooth arrangement, size and color can be made with minimal lab expense.
If the letter doesn't get you anywhere, you might try going to the governing body of the dental profession in your area. I am a dentist in Blue Springs, Missouri, USA. Here, we have the Missouri Dental Board (or the Dental Division of the Missouri Department of Professional Registration.) This is the entity that licenses us to perform our professional duties in our state. They often have a process to file complaints against a provider if you were unable to resolve the problem yourself. After your complaint is received, they will contact the doctor to get their side of the story, then try to mediate a solution between the two parties.
As far as a new set of dentures, you might seek out the services of a Prosthodontist (specializes in dentures and removable appliances - extra training and certification beyond general dentistry) or go to a local dental school. The students are supervised and checked off at each step by professionals. Most dental schools also treat patients through their faculty practices, and you can often get the services of a specialist at a lower price.
I hope this information is helpful to your situation, and I wish you well.
Beth Gehring, DDS
816 NW Vesper
Blue Springs, MO 64015 USA
Have you checked Angie's List? Angie's List Answers is a great place to find advice from professionals, but for ratings, reviews and information to find the doctors you need, visit www.angieslist.com today.
Dentistry reviews in Kansas City
Dentists in Kansas City
Aarons, Dr. Kurt A
Kansas City
Abdulmola Al Salman DDS
Kansas City
Abernathy, Dr. Robert E
Adam Colombo D.D.S., P.A.
Adam Flack DDS
Kansas City
Adam Naler DDS
Kansas City
Adam Retallick DDS
Adam Westfall DDS
Platte City
Adams Dental Group
Addy, Dr. Nancy L
Adjemian, Dr. Arsen
Kansas City
Affordable Dental of Olathe
Aime Broyles DDS
Lees Summit
Akimoto, Dr. Stephen D
Kansas City
Alamachu, Dr. Kali N.
Alan Martin DDS
Albert Natanov DDS
Alex Motaref DMD
Kansas City
Alexander, Dr. Ronald W.
Alexandra Gier DDS
All Smiles Family Dentistry
Allan Reichman DDS
Allen, Dr. Charles H
Kansas City
Allen, Dr. Gregory
Allman, Dr. Kevin C
Altenburg, Dr. Stephanie
Kansas City
Altnether, Dr. Daniel
Altnether, Dr. Daniel J.
Alva Edwards DDS
Kansas City
Amanda Whiting DDS
Amara Burki Napper DDS
Amazing Smiles of Kansas City
Ameryun, Dr. Stephan A.
Kansas City
Amish Patel DDS
Kansas City
Amit Kumar DDS
Kansas City
Amy Bagley DDS
Kansas City
Amy Burleson DDS
Kansas City
Amy Fisher DDS
Kansas City
Amy Tasca DDS
Anderson & Associates
Kansas City
Anderson, Dr. Eugene F
Anderson, Dr. Eugene F.
Anderson, Dr. James R.
Kansas City
Anderson, Dr. Mark A
Anderson, Dr. Thomas L
Kansas City
Andrea Gordon DDS
Kansas City
Andrew Mark Sousa DMD
Kansas City
Andrew S Beyer, DMD
Kansas City
Andrew Sousa DMD
Andrew Vanblarcom DDS
Aniika Jackson DDS
Kansas City
Ann Fay DDS
Ann L Barber DDS
Anna Jones DDS
Anne Johnson DDS
Kansas City
Anthony Line DDS
Anthony Trakas DDS
Blue Springs
Anthony Williams DDS
Blue Springs
Antioch Dental
Antioch Dental Group Inc
Kansas City
Anton Vierthaler DDS
Kansas City
Anuja Buch DDS
Anush John DMD
Kansas City
April Champen-Washington DDS
Kansas City
Arjes, Dr. Douglas W
Kansas City
Arsen Adjemian DDS
Kansas City
Artis Clark DDS
Kansas City
Ashley & Gray DDS
Ashley Cox DDS
Kansas City
Ashley Knight DDS
Associates in Dentistry
Associates in Family Care
Asvin Vasanthan DDS
Kansas City
Audell Billingsley DDS
Audra Ward DDS,DMD,MS
Autumn Dental Care
Ayer, Dr. Dennis C.
B R Rommel
Kansas City
Bagby, Dr. Thomas K
Bahr, Dr. A. John
Blue Springs
Baker, Dr. Steven R
Baldwin, Dr. George A
Barbara Schupp DDS
Kansas City
Barber, Dr. Ann L
Barreca, Christopher DDS
Kansas City
Barrow, Dr. Bruce K.
Kansas City
Barry Burgess DDS
Barton, Dr. Hodes L
Barton, Dr. Thomas F
Kansas City
Bassam Badr DDS
Bastian, Dr. Robert S
Beard, Dr. Mark
Kansas City
Beauregard Michael
Beckman, Dr. Jason
Kansas City
Beckon Brown DDS
Kansas City
Bednarczyk, Dr. Daniel
Behrens, Dr. DeeAnn R.
Bel-Air Dental Care Chartered
Belfield Dr, James
Beltgens, Natalie
Blue Springs
Belton Modern Dentistry
Benjamin Sparks DDS
Benjamin Unruh DDS
Benjamin Westman DDS
Kansas City
Bennett Turnbow DDS
Berkvam, Dr. Dawn L
Kansas City
Bernard G Bruns DDS, LLC at Tremont Dental
Kansas City
Bernard Williams DDS
Beverly Moon DMD
Bhoot, Dr. Sonal
Lees Summit
Bhoot, Dr. Sonal
Biggs & Biggs DDS
Biggs, Dr. Robert
Bikson, Dr. Bruce
Bikson, Dr. Bruce
Bikson, Dr. Bruce
Billingsey, Dr. Ann
Billingsley, Dr. Ann
Billy Rommel DDS
Kansas City
Blacker, Dr. Mitch
Kansas City
Blackmon, Dr. Amanda M.
Blue Springs Dental Group
Blue Springs
Blue Valley Cosmetic and Family Dentistry
Blue Valley Cosmetic and Family Dentistry
Blue Valley Dental Care
Bob Craven DDS
Boland, Dr. Robert
Kansas City
Bono, Dr. Thomas J
Kansas City
Bono, Dr. V Michael
Boomsaad, Dr. Oscar
Boring, Dr. Charles A.
Bowden, Dr. Rand
Bowen, Dr. Jeremy L.
Bowles, Dr. Chad A.
Boydston, Dr. Harry L.
Boyle, Dr. Tara D.
Brad A Higgerson DDS
Bradford Place Family Dentist
Bradley Babcock DDS
Bradley Smith DDS
Lees Summit
Bradley Smith DDS
Brandon James
Brandon Tilts DDS
Brenda Bohaty DDS
Kansas City
Brendan Duede DDS
Brent Vonbehrens DDS
Brenton Reavley DDS
Kansas City
Brett Ferguson DDS
Kansas City
Brett Sullivan DMD
Kansas City
Breuckmann & Ross
Breuckmann, Dr. Karl A.
Breusing, Dr. Charles
Kansas City
Brian Ahern DDS
Brian Pannell DDS
Kansas City
Briarcliff Dental Care
Riverside (Kansas City)
Bridenstine, Dr. Kelly
Brobst, Dr. Edward
Brockmann, Dr. William
Kansas City
Brookside Dental Center
Kansas City
Brookside Family Dental
Kansas City
Brower Dental Group
Lees Summit
Brower, Dr. Harold
Lees Summit
Brower, Dr. Todd
Lees Summit
Brown Jr, Dr. William L
Kansas City
Brown, Dr. David V.
Brown, Dr. James
Kansas City
Brown, Dr. Jeffrey N
Kansas City
Brown, Dr. Laura E
Brown, Dr. Melissa L.
Browne, Dr. Jon E
Bruce Barker DDS
Kansas City
Bruce Derr DDS
Kansas City
Bruce E Rosenbaum DDS
Lees Summit
Bruce K. Barrow DDS
Kansas City
Bruner, Dr. Hugh H.
Bryan Shewanick DDS
Kansas City
Bryant Phye DDS
Bucher Family Dentistry
Budig, Dr. Christopher G.
Buford Hamilton DDS
Bunton, Dr. J. Garrett
Kansas City
Bunton, Dr. Ryan G
Kansas City
Burg, Dr. George F
Burgmeier, Dr. Ron J.
Burk, Dr. Kurt
Kansas City
Burks, Dr. William H
Burns Dental Care
Kansas City
Burns, Dr. David
Kansas City
Burns, Dr. F Robert
Burns, Dr. Robert
Kansas City
Burns, Robert C
Kansas City
Burris, Dr. Todd C.
Burrow Family Dentistry
Busch, Dr. Bill
Kansas City
C S Wolff
Kansas City
Cabot Westside Clinic
Kansas City
Caleb Gardner DDS
Kansas City
Callison, Dr. Anthony
Camille Hostetter DDS
Kansas City
Capstone Dentistry
Careswell, Dr. Holli
Lees Summit
Caring Dental Inc
Carla Daugherty DDS
Kansas City
Carla Evans DDS
Carla King DDS
Kansas City
Carlson, Dr. Steven R.
Kansas City
Carol Jones DDS
Carr, Dr. Lauren
Carter-Oshea, Dr. Susan
Caryl Earp DDS
Casey, Dr. Joanna L.
Casper, Dr. Roger L
Lees Summit
Cass County Dental Clinic LLC
Cass County Smiles Dentistry
Castaneda, Dr. Alberto R.
Castellano, Dr. Anthony R.
Kansas City
Catherine Mowry DDS
Catherine Uypeckcuat DMD
Cattaneo, Dr. Kevin A.
Chad Barth DDS
Kansas City
Chad Bulleigh DDS
Chad Heath DDS
Chad Wollard DDS
Kansas City
Chand, Dr. Suman
Kansas City
Chang, Dr. Youngjune
Charles Bishop DDS
Kansas City
Charles Dunlap DDS
Kansas City
Charles Haley DDS
Charles Kavanaugh DDS,PC
Kansas City
Charles Klestinske DDS
Charles Lee DDS,MS
Charles Pohl DMD
Charles Swain DDS
Charles Wolff DDS
Kansas City
Charlyne Mason-Dozier DDS
Kansas City
Chase Dansie DDS
Chesterfield Dental Associates
Children's Mercy Hospital CAR
Kansas City
Chris Wenburg DDS
Christopher Dumas DDS
Kansas City
Christopher Mcdaniel DMD
Kansas City
Christopher Thompson DDS
Kansas City
Christopher Vogel DDS
Kansas City
Christopher Wick DDS
Kansas City
Chyong-Ying Whang DDS
Kansas City
Ciminieri, Dr. Jason R
Claassen, Dr. Robert L.
Kansas City
Clarence Simmons DDS
Kansas City
Claudia Lopez DDS
Clemens, Dr. Mark A
Clement Schmitt DDS
Kansas City
Clemons, Dr. Trevor
Clifford Anderson DDS
Kansas City
Clifford Vanblarcom DDS
Clinton Johnson DDS
Kansas City
Cobb, Dr. David
Cochran, Dr. Douglas J.
Collins, Dr. Patrick H
Blue Springs
Comfort Dental - Noland Road
Complete Dental Care
Cope, Dr. John M.
Cope, Dr. Susan P
Copper Oaks Dental Arts LLC
Blue Springs
Corey Auch DDS
Kansas City
Corey Hinrichs DDS
Corinth Dental Care
Courtney, Dr. Gary D
Cox, Dr. Kenneth M
Kansas City
Craig & Tim Herre DDS
Craig Alexander DDS
Craig B Marshall DDS
Kansas City
Craig Winters DDS
Craig, Dr. Aaron M
Craven, Dr. Scott
Creighton Gallagher DDS
Crowder, Dr. Rick
Culp, Dr. Steven M
Cummings, Dr. Bruce C.
Kansas City
Cummings, Dr. Jane L.
Kansas City
Cummings, Dr. Kevin J.
Lees Summit
Cummings, Dr. Matthew J.
Lees Summit
Curtis Alexander DDS
Cynthia Petrie DDS
Kansas City
D M Monheiser
Blue Springs
D S Thomas
Kansas City
D Stanley Hite DDS
Dahlquist, Dr. Carlyle H.
Blue Springs
Dale Cipra DDS
Dale Greer DDS
Dale Watts DDS
Dale, Dr. Gregory W.
Kansas City
Dan Ang DDS
Kansas City
Dan Blackwell DDS
Lees Summit
Dan Miller DDS
Daniel C Chelius JR.
Kansas City
Daniel Colgan DDS
Daniel Gilstrap DDS
Daniel Huerter DDS
Daniel J Duello DDS
Lees Summit
Daniel Johnson DDS
Kansas City
Daniel Shin DDS
Daniel Tokar DDS
Kansas City
Daniel Wolf DDS
Darnall, Dr. Thomas M.
Darrell Davis DDS,DMD,PC
Darren Perry DDS
Davenport, Dr. Justin M
David A Schaefer DDS
David Ashley DDS
David Christensen DDS,DMD,MS
Kansas City
David Cohen DDS
David Dykhouse DDS
Blue Springs
David Ewing DDS
David Ferguson DDS
David Greenhalgh DDS
David Hanson DDS
Kansas City
David Jaeger DDS
David Juhn DDS
David Koepsel DDS
Kansas City
David M Swee
David M Swee DDS
Blue Springs
David Merello DDS,DMD,PC
Pleasant Hill
David Ruder DDS
David Stamos DDS,DMD,MS
David Tuttle DDS
David Vantasell DDS
Kansas City
David Vasquez DDS
Kansas City
David W Juhn DDS
David Western DDS
Kansas City
David, Juhn W
Davidson, Dr. Lindsay
Davis Family Dental
Kansas City
Davis, Dr. Ali
Kansas City
Davis, Dr. Carter
Davis, Dr. Darrell W
Davis, Dr. Robert
Davis, Dr. Robert
Kansas City
Dawn Berkvam DDS
Kansas City
Dayna Brinckman DDS
Dean F. Kirn DDS
Dean Kirn DDS
Deaun Regan DDS
Deay, Dr. Robert D
Debra Ann Wilkinson Dds
Blue Springs
Debra Wilkinson DDS
Blue Springs
Deer Creek Family Dental Care
Delightful Dental Care
Kansas City
Denise Hamlin DDS
Denise Hogard DDS
Dennis Ayer DDS
Dennis Demskey DDS
Dennis Edsall DDS
Kansas City
Dennis Gemar DDS
Dennis Haller DDS
Dennis Harper DDS,MS
Dennis Runser DDS
Dental Care Center
Kansas City
Dental Designs
Kansas City
Dental Elements of Overland Park
Dental Excellence
Dental Innovations
Dental Services
Kansas City
Dental Smilemakers: Michael S. Meilink, D.D.S.
Kansas City
Dentistry for Children - Gladstone
Dentistry for Children - Liberty
Dentistry On Douglas Street LLC
Lees Summit
Dentures & Dental Services
Derek Gilmore DDS
Derek Williams DDS
Kansas City
Derenzy, Dr. Brook A.
Deskin, Dr. Ronald
Deutch, Dr. Michelle B.
Dewain Whitmore DDS
Kansas City
Deyton, Dr. Guy S.
Kansas City
Dhyanesh Suresh DDS
Blue Springs
Dighton, Dr. Mary C
Discover Dental Care
Dix, Dr. Michael E.
Dixson, Dr. James J.
Dolson, Dr. Mark
O Fallon
Don Hite DDS
Don Macauley DDS
Donald Haun DDS
Donald Howe DDS
Lees Summit
Donald Meiners DDS
Donald Monheiser DDS
Blue Springs
Donna Deines DDS
Kansas City
Donna Gardner DDS
Dorsey Moore DDS
Kansas City
Dostal, Dr. Mike
Dotson, Dr. Peter H
Kansas City
Douglas Crawford DDS
Douglas Dr. Schulz DDS
Douglas Fain MD,DDS
Douglas Lerner DDS
Douglas Pearson DDS
Kansas City
Douglas Walters DDS
Kansas City
Dr Carter Davis DDS
Dr Douglas Knop
Dr. Anthony Marengo, Jr.
Dr. Baron Grutter DDS
Kansas City
Dr. Bellem
Kansas City
Dr. Betty Horstmann
Kansas City
Dr. David Mitchell DDS
Dr. David Platt
Kansas City
Dr. Hartman & Associates Dentistry
Dr. J Robert Mobley
Kansas City
Dr. Jill C Jenkins DDS
Dr. John H Mcknight, DDS
Dr. John R. Gordon, DDS
Kansas City
Dr. John Snow D.D.S.
Dr. Jon G. Bevan
Dr. Kelly F Grosdidier OD
Dr. Kristopher J. Bruso
Kansas City
Dr. Laura Bowden DDS, DMD
Dr. Lewendowski
Dr. Michael P. Berry and Dr. Andrew M. Sousa
Kansas City
Dr. Molly Frew Hodges
Kansas City
Dr. Nick Houk
Excelsior Springs
Dr. Nora Frandsen
Kansas City
Dr. Robert J. Seaman Jr, DDS
Dr. Sheila R Jungmeyer
Lees Summit
Dr. Steven C Mingos & Associates LLC
Kansas City
Dr. William Ledford, DDS
Kansas City
Duello, Dr. Daniel J
Lees Summit
Duensing Family Dentistry
Kansas City
Dustin Burleson DDS
Kansas City
Dyer-Chenoweth, Dr. Diane
Dyne, Dr. Stephanie Van
Earl Mchugh DDS
Kansas City
Eastland Family Dental LLC
Ed Hunter DDS
Excelsior Springs
Edgington, Dr. Blair
Kansas City
Ediger, Dr. Gordon
Edis Wu DDS
Kansas City
EDward Amet DDS,BS,MSD,FACP
Edward Cable DDS
Edward Cantrell DDS
Edward Dallam DDS
Edward Haggerty DDS
Lees Summit
Edward Nelson DDS,PA
Edward Oman DDS
Kansas City
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Kansas City
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Kansas City
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Kansas City
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Kansas City
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Kansas City
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Kansas City
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the nacis have become zombies and you're a military soldier who has to fight them to stay alive. kill all the zombies nacis to get money and buy new weapons
the nacis have become zombies and you're a military soldier who has to fight them to stay alive. kill all the zombies nacis to get money and buy new weapons
Play this unity 3D where you have to kill the zombies trying to attack you to eat your guts. Go on a military base where everyone is infected by a zombie virus. How long can you survive ?. Aim, shoot and explore
all Santa's helpers elves have become zombies and want to steal all the toys in the house of Santa Claus. you have to shoot the mutant zombies and try not to let the house of santa claus
turns your chainsaw and kill all humans who find in the hospital, if it survives any human try to find another devastating weapon
scampers zombies to shoot and destroy them all. you have to survive the massive waves of zombies coming to kill you. your mission is to escape alive with the help of a vehicle. kill the zombies to get new weapons.
approaching halloween night and this morning have raised all this cemetery not alive. he points to the head and bust all the heads of these zombies. get money to buy new weapons
cursed zombies have killed an entire population. It is a great plague and a pest that is, we must exterminate. aided by moving the cursor to the letter "z to shoot, the letter X to hit and the letter A is the action.
Play this exciting game to kill mutants. choose your favorite and kills all mutants that are released to you weapon. shoots the head to get the highest score
the apocalypse has come and the iron maiden wants to save from this nightmare. shoot all the enemies before they end up with your life
go in search of all persons who are unable to survive without you. salvales and kill all the zombies that can harm your refugees.
the city is plagued by zombies and your mission is to place dynamite in the most critical places to do the most damage. use your intelligence to blast all the zombies game
great shooting game where you have to kill zombies and terrorists. choose the game mode you want to play: Kill zombies or kill terrorists. earn points to redeem for upgrades and new weapons
have a good time playing this fun mini-game to kill zombies. you can choose between three different characters, you can also invest your money to buy new weapons and upgrades
a holeada zombie approaching your farm threatening to destroy everything in its path. you have to stop them. use a chainsaw to cut up the zombies, remember that you can not let these zombies
you are in the dark night in the middle of nowhere where zombies out of the ground and your goal is to survive until they rescue. looking objects to use the crafting table and create new weapons. create weapons to annihilate the zombies !.
It's night and it's all very dark, but the problem is that a wave of zombies are close to you. you have to kill the zombies to get money, with the money you collect can buy upgrades and new weapons
are 0:00 on the 1st of November and the dead from the area come to life. you have to kill all the zombies with your gun, kill more zombies the more money you will receive. get money to buy better weapons
a huge wave of hungry zombies are coming and you have to protect yourself with an AK-47 survives this wave and save your life
in the city where the boy lives around the world to become zombies. You have to survive the wave of zombies who want to eat and for this you have to kill all the zombies that approach
Kill all the zombies that come out on screen. Select the appropriate type of weapon and shoot without mercy. Must overcome several phases to reach the end of the game.
great action game where you`re an everyday citizen who wants to kill all the zombies in your city. your mission is to kill all the zombies and collect all the weapons that you offer
survives a huge wave of hungry zombies shooting your gun. get new weapons as you go from level. try to reach the end of the mission to save humanity
defend your truck zombies shooting your devastating weapon. get money to buy new weapons and upgrades
Play this fun shooting game where you are a mercenary old with a gun and you have to prevent a wave of zombies can enter the city downtown. You do not waste your money and invests in buy upgrades and new weapons
This bear must protect the walls protecting his village of evil zombies and it will have to fight them. combating all zombies and not let any alive
In this game you have to protect a holeada of hungry zombies who want to eat your brain. collect all the weapons you find on the screen so it will be easier to kill the zombies
zombies threaten to destroy the city and you have to stop creating elite soldiers to kill all the zombies in each building
a wave of zombies come running towards your truck and your mission is to shoot all the zombies to kill them all. get money to buy weapons and upgrades for the truck
collect all the weapons you can and get to shoot all the zombies that come through the window of your cusa. invests the money earned to purchase weapons and upgrades
you alone can exterminate the zombies in this city, you visit the cemeteries of zombies to annihilate everyone and not leave none alive, otherwise the zombies take control of the city and your life will be over
have a good time killing zombies. you have to survive the maximum number of massive waves of zombies. how long can you hold out?
zombies want to catch you because you`re the only human in town and still eat your tracks, you have to protect yourself using the weapons and use the car to run over the maximum possible zombies
a massive wave of zombies want to infect us with a deadly virus. we'll have to be careful with these zombies smokers, we have to point and shoot to eliminate them all. visit gun shop to compare improvements and new weapons
all your classmates have died from attacks by zombies. now you are alone with a gun. move around the building killing zombies to get away and call for help. be very careful not wrong to spend the ammunition you are short !.
see to kill all the zombies that there are around you before they kill you.
you are destined to explore an island full of mutant zombies in order to eliminate all the enemies zombies and find an antidote to cure the zombie virus
your spaceship is damaged and you have to fix it before the zombies on this planet completely shred and no longer be under not want to stay on this planet infested with zombies truth!
asian attack zombies is a survival game where you have a gun to hold the zombie invasion. how many waves can endure?
your pirate ship is shipwrecked on a strange island which is full of zombies pirates threaten to steal all the treasure ship. you have to defend your treasure from the zombies by shooting and killing them all.
Will you be able to protect the treasure of the pirate invasion ?. Pirates have become zombies and not fear death. They want to steal your treasure encañado boat and you have to protect it at all costs. Shoot without mercy to not leave any.
play this game of zombies in which you will be surrounded by them and must kill all.
a zombie has made you one of them, and you feel really bad, you should get your normal appearance with the antidote but beware going to trial.
It is the night of Halloween and all the dead have come to life. you have to stop the wave of zombies to protect all your friends and family in this city. Fight and learn new combos to make them easier to extermination
You have a mission to kill all zombies halloween night. It is the night of Halloween and all the dead are digging up and want to eat all living
They have become the final day started and the non-living into zombies. your mission is to kill all the zombies, buy upgrades and new weapons to find a way out
the city where you live is to produced an escape of a virus capable of turning into a zombie all who breathe in these bacteria, but luckily still alive and have to fight against dozens of zombies mutants to find a solution
If you love zombie games this insurance game you like. you're the only cop who is alive and your mission is to kill all the zombies and rescue humans from the clutches of these monsters
great action game where you have to kill all the zombies Avenue to get out alive. choose the character that you want and fight a wave of mutant zombies
I have many more !!!, play it without limits, free Kill zombies Games, Select your page


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Whether you're planning your own registry or looking to purchase something for someone else, narrowing down the options for purchase are daunting. When I created our registries, I was overwhelmed by the amount of options I could consider and the range of products and prices for which I could register. Now when I think about what I would ask for with a new home vs. what I did ask for when I shared a 600sq ft apartment, a number of helpful items come to mind. With that I compiled this list of 6 items every wedding registry needs that involves work in the kitchen. I'm going to start with sharing what the kitchen starter could really use.
- Nesting Bowls – A set like these can be inexplicably helpful in a tiny kitchen. I am especially fond of my set with rubber bottoms to keep them from slipping or hopping all over the countertops. Metal insides are perfect for hand mixers, while glass nesting bowls are timeless looking, can be heated (in most cases), and any set that comes with lids are so important for pulling double duty in a small kitchen. While I prefer to have 2 sets of nesting bowls in my kitchen, I keep my metal bowls close at hand and my glass bowls in the basement for when I need them.
- Cast Iron Enameled Oven – If I were stranded on a desert island, a cast iron enameled oven would be the second thing on my list (right after a water filter). A 6qt oven is large enough to roast a chicken but small enough that it will still fit in most cabinets without issue. They can be quite beautiful too! Sometimes I just like to leave mine on the stove, as its orange color adds to my kitchen nicely. Be sure to try and match the couple's registered items if possible (i.e. if they register for all blue dishware, sometimes a blue enameled oven is a nice touch. Other times it's nice to contrast). Whether you go with a cost-effective brand like Lodge or a gourmet brand like Le Creuset, be sure to check the cookware for warranty info and any flaws in the glaze.
- Storage Containers – Glass is where it's at. These Pyrex containers are mandatory for anyone looking to cook more at once or more often in general. The shelf life of this set with heavy use is about five years, which I find to be better than the snap on lids' shelf life. The bottoms are oven safe (great for reheating food in the oven, toaster oven, or microwave) and the sets are dishwasher safe. Any couple would get use out of the set for storing leftovers, lunches, or fresh ingredients for prep.
- Cuisinart Food Processor – When storage is limited, some items have to be versatile. I have found Cuisinart to be just that. It's great at blending things a blender can't handle, and also has extra graters and add-ons to speed up the prep process. At around $100 for a 7-cup processor, it's a good moderately priced gift option. Looking for a more affordable option for your registry? We have the 3-cup Cuisinart at home and it takes care of most small projects.
- Quality Kitchen Knives – A quality set should include a paring knife, a cook's knife, and a shorter utility knife is always nice. Quality high-carbon stainless steal will last and last. The only other item that I love that isn't in the above set is a pair of their Wusthof Kitchen Shears.
- Pepper Grinder & Salt Pot – I'm in a stage of my life at the moment where I want a salt pot instead of a shaker – but it's nice to get back to my classic salt and pepper shakers when we have guests over. While many households may already have a table set for salt and pepper, having a go-to pepper grinder next to the stove can help food immensely! A salt pot also looks tasteful next to the stove, and mine allows me easy access to a large opening should I decide to measure my salt out instead of using my hands (albeit more times than not I'm just using my hands – and have you ever tried to measure teaspoons of salt out of those tall salt canisters?! Impossible.) Remember to include some fresh salt (Himalayan sea salt perhaps?) and peppercorns if you're the one gifting! They add a lovely personal touch.
Just you wait–I'm compiling a list for kitchen pros as well 😉


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Hotel Resol Trinity Sapporo
Hotel Resol Trinity Sapporo
Hotel Freebies Available*
• Free Internet in Room show dates
Hotel Resol Trinity Sapporo
Stop at Hotel Resol Trinity Sapporo to discover the wonders of Sapporo. The hotel has everything you need for a comfortable stay. Free Wi-Fi in all rooms, luggage storage, Wi-Fi in public areas, car park, restaurant are on the list of things guests can enjoy. Some of the well-appointed guestrooms feature internet access - wireless (complimentary), internet access - wireless, wake-up service, non smoking rooms, air conditioning. The hotel offers various recreational opportunities. No matter what your reasons are for visiting Sapporo, Hotel Resol Trinity Sapporo will make you feel instantly at home. ...read more
Hotel Resol Trinity Sapporo Amenities
- Air Conditioning
- Bathtub
- Bicycle Rental
- Car Park
- Elevator
- Free Wi-Fi In All Rooms
- Hair Dryer
- Inhouse Movies
- Internet Access - Lan
- Internet Access - Lan (Complimentary)
- Japanese
- Laundry Service
- Luggage Storage
- Massage
- Non Smoking Rooms
- Refrigerator
- Restaurant
- Satellite/Cable Tv
- Shared Bathroom
- Shower
- Smoking Area
- Spa
- Television
- Television Lcd/Plasma Screen
- Vending Machine
- Washing Machine
- Wi-Fi In Public Areas
from $59
- Hotel Okura Sapporo from $167 (0mi)
- Nest Hotel Sapporo Odori from $226 (0.1mi)
- Apa Hotel Sapporo (0.2mi)
- Dormy Inn Premium Sapporo from $133 (0.2mi)
- Dormy Inn Sapporo Annex from $99 (0.2mi)


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STATE OF AFFAIRS, Starring Katherine Heigl, Gets Series Order at NBC
|Related Links
|New Sport Show ESCENA DEPORTIVA to Debut on NBC Universaro, Today
May 21, 2015
|Update: NBC Cancels CONSTANTINE, STATE OF AFFAIRS, MARRY ME & ABOUT A BOY
May 08, 2015
|Scoop: TODAY on NBC - Week of May 11, 2015
May 01, 2015
|NBC's SUNDAY NIGHT FOOTBALL is #1 Telecast Among Big 4
December 23, 2014
|Related: STATE OF AFFAIRS, NBC, Katherine Heigl, Universal TV
Variety reports that NBC has drafted STATE OF AFFAIRS to series. The CIA drama stars Katherine Heigl and comes from executive producer and writer/director Joe Carnahan (The Blacklist).
Read the original story here.
The drama centers on a key CIA attaché (Heigl) who "counsels the president on high-stakes incidents around the world." Alfre Woodard (12 Years a Slave) will take on the role of Commander in Chief.
Also in the cast are Adam Kaufman, Sheila Vand, Cliff Chamberlain, Tommy Savas and Leslie Odom, Jr.
Alexi Hawley and Carnahan will excutive produce along with Heigl, Bob Simonds, Henry Crumpton and Julia Franz.
About Author
- CNBC to Air THE MAKING OF DIG, the USA Network Event Series, 3/1
- NBC to Air One-Hour Season Finale of CHRISTINA MILIAN TURNED UP, 3/1
- NBC Universo to Present ROMEO SANTOS DESDE VINA Concert Exclusive, 3/1
- Kelly Clarkson to Visit CBS SUNDAY MORNING, 3/1
- VIDEO: Clark Gregg Teases New AGENTS OF S.H.I.E.L.D. Season Using Emojis
- Dakota Johnson to Host SNL Tonight; Alabama Shakes to Perform
- NBC Sports to Air Coverage of U.S. GRAND PRIX FROM PARK CITY
- Discovery Family to Premiere New Episodes of TRANSFORMERS RESCUE BOTS, Today
- Telemundo to Present FUTBOL ESTELAR: LEON VS SANTOS, Today
- Telemundo to Give Viewers Sneak Peek at Upcoming Programming on LO NUEVO, Today


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Just updated my home workspace. I'm now running a 13" MacBook Air (i7 processor, 8GB RAM, 512 SSD) on an mStand by Rain along with my old Samsung 24" LED monitor. Seems to be doing the job so far =)
More Adham Dannaway
keyboard shortcuts: ← previous shot → next shot L or F like Z toggle zoom


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
42 year old woman | Pompano Beach, FL, USA | Seeking men 40-51 within 50 miles
I'm a well rounded, energetic, and honest...
I'm a well rounded, energetic, and honest woman that loves to laugh and enjoys what life has to offer. I'm looking for someone with similar characteristics. I like to work out, go to sporting events, hang out with friends, go to concerts, and go out to nice dinners. Although I enjoy going out and being social, I also enjoy nights in. I'm looking for an honest and optimistic man who is a gentleman that makes me laugh and makes me a priority. I go out of my way to make someone feel special and needed; I give 110% and I expect the same in return. At the end of the day, I want to come home to my best friend. A best friend that shares my goals and interests. If you're interested in starting a friendship and seeing where it goes, let me know!
Coffee and conversation , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Aerobics, Baseball, Billiards / Pool, Bowling, Cycling, Dancing, Football, Other types of exercise, Swimming, Walking / Hiking, Weights / Machines, Yoga
I exercise 5 or more times per week.
I like Cats, Dogs
Middle of the Road
I enjoy going to las olas and Del ray for a nice dinner. sports bars are fun especially during football season.
The Art Institute of Fort Lauderdale, Fort Lauderdale, FL
I enjoy trying new restaurants and different types of cusines. I'm willing to try almost anything once. If I had to pick a favorite it would be a good steak and lobster. I also enjoy the random rainy day. It's great excuse to stay in bed and play.
Love to take my bike out and ride to the beach and local restaurants
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'6" (167cms)
|5'11" (180cms) to 6'5" (195cms)
|Body type:
|Athletic and toned
|About average, Athletic and toned
|No preference
|Light brown
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker
|Medical / Dental / Veterinary / Fitness
|No preference
I do cardiac ultrasound in a hospital
|$50,001 to $75,000
|$75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married, Widow / Widower, Currently Separated, Divorced
|Have kids:
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|I'll tell you later
|White / Caucasian
|Latino / Hispanic, White / Caucasian
|Christian / Catholic
|Agnostic, Atheist, Christian / Catholic, Christian / Protestant, Spiritual but not religious, Christian / Other
|Associates degree
|Some college


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Italian Pumpkin Strata
4 May 2010
|Vegetable oil
|1 Tablespoon
|Sweet italian sausage links
|1 Pound, casings removed
|Chopped onion
|1 Cup (16 tbs) (1 Small Sized)
|Chopped green bell pepper
|1⁄2 Cup (8 tbs)
|Chopped red bell pepper
|1⁄2 Cup (8 tbs)
|2 Clove (10 gm), finely chopped
|Italian bread/French bread
|3⁄4 Pound, cut into 1 1/2-inch cubes (12 Cups, About 3/4 Of 1 Pound Loaf)
|Shredded mozzarella cheese
|8 Ounce (2 Cups)
|Evaporated milk
|24 Fluid Ounce (3 Cups, 2 Cans, 12 Fluid-Ounce Each)
|Canned solid pack pumpkin
|15 Ounce (1 3/4 Cups)
|1 Teaspoon
|Ground black pepper
|1⁄2 Teaspoon
|Dried oregano
|1⁄2 Teaspoon, crushed
|Dried basil
|1⁄2 Teaspoon, crushed
|Dried marjoram
|1⁄2 Teaspoon, crushed
HEAT oil in large skillet over medium-high heat.
Add sausage, onion, bell peppers and garlic.
Cook, stirring to break up sausage, for 7 to 10 minutes or until sausage is no longer pink; drain.
COMBINE bread cubes, cheese and sausage mixture in large bowl.
BEAT eggs, evaporated milk, pumpkin, salt, pepper, oregano, basil and marjoram in medium bowl.
Pour over bread mixture, pressing bread into egg mixture.
Pour into 13 x 9-inch baking pan.
Recipe Summary
Difficulty Level:Easy
Rate It
0 Comments
Italian Pumpkin Strata Recipe


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Join us in building a healthy environment and promoting sensible security policies. Make a donation to Washington PSR today
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Picture yourself in front of a professional mixing board inside a modern Hollywood studio. If that sounds like your dream — turn up the volume.
Music is your life. Take it beyond the next level at the center of the music industry in Los Angeles.
Animation is about creating new worlds. True artists and illustrators at heart, our students are looking for a creative escape from the mundane to the fantastic. Armed with their imagination, they live an animated life.
Creativity is not just for the arts anymore. Our Entertainment Business program is focused on innovation and unique points of view.
Sometimes you have a dream so big, it's hard to fit it into your life, but in our digital age, it's not impossible to get those dreams in line when you can learn them online.
Currently, all of The Los Angeles Film School's on-campus degree programs will be available at reduced tuition rates for a limited time. If you're ready to start your education at The Los Angeles Film School, apply today for the July 6, 2015 start.


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1993 Nissan Altima Repair and Maintenance
A guide to problems, costs, maintenance and repair for your 1993 Nissan Altima
- My cars muffler has been very loose for about a month. Now it chugs and has no pick up. Is it the muffler that caused that? Thank you very much for any help.
- When Starting my car the idle doesn't stay above one without pressing the gas an
- I know how to get it out of the spindle, what I need to know does it split apart
- how to remove right side cv axle from 1993 nisson Altima?
- What parts do I need to replace my exhaust system?
- AC Compressor Replacement $736 - 992
- Intake Manifold Gasket Replacement $527 - 671
- Water Pump Replacement $324 - 462
- Oil Pump Replacement $1,036 - 2,014
- Head Gasket(s) Replacement $865 - 1,994
- Ray & Dana's Inman Auto Care (732) 856-5054 | 3.46mi
- 12 Volt Doctor (718) 412-9553 | 2.98mi
Related Content
1993 Nissan Altima Problems
The camshaft driven distributor can leak oil and cause a malfunction of the crankshaft position sensor. The engine may crank but not start or run very poorly.
Failure of the ignition power transistor can cause a "crank-no start" condition.
Regular maintenance is recommended to avoid timing chain failure. Rattles may develop in higher mileage vehicles. Regular oil changes will help reduce the incidence of this problem.
1993 Nissan Altima Questions
1993 Nissan Altima Recalls
Nissan is recalling 1993-1994 Altimas because engine movement can be transmitted to the airflow meter/filter housing and support bracket, which can cause the throttle cable housing to pull out of the cable guide. This may prevent the throttle from returning to the idle position when the gas pedal is released, resulting in loss of throttle control that can cause an accident. Nissan will examine and repair/replace the throttle cable housing, insert a rubber stopper to maintain position for the cable, and replace the throttle assembly, if necessary.
1993 Nissan Altima Reviews
Bought my 93 Altima 8/2001 had 89,000 miles at the time. Now 10 years later 303,000 miles and running strong. Dig this 5 speed with original clutch. Great car


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Does anyone have the rear hatch glass? Also want the rear quarter panels.
Type: Posts; User: DAVEG
Does anyone have the rear hatch glass? Also want the rear quarter panels.
where did you buy this I am looking for replacement glass.
Parts still available.
Do you have any Rabbit GTI interior parts such as door cranks or door panels?
I have some carpet templates so you can make your own custom carpet 11 piece easy to install and remove for cleaning.
I have the stock piece that fits on the bumper Three different parts.
I am looking for an arm rest, window cranks for a red GTI...
What condition are the arm rests? If they are nice I can buy.
How much for the entire car???????????
Yu will have to check the part #...if you have a 90-92 GTI/GLI or a MK III golf with rear disks theyshould be the right length. Tell me your cable length and I will measure. You can see the ends. ...
Still available
Still available yours for $40 including shipping.
Rear disks.
I have unused emergency brake cables for any Golf/Jetta using rear disk brakes 90-92 GTI GLI
Asking $30 for both +...
Still for Sale
Cables brand new available for Golf or Jetta


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This 2008 Dodge Charger SRT8 has a 6.1 Liter Supercharged Hemi V8 (672 HP), 5 Speed Automatic Transmission, Tuned by ''Mr. Norms Garage'', 672... More
2008 Dodge Ram 3500, Mega Cab, Cummins Diesel, Resistol Appearence, Navigation, DVD, Sunroof. One owner, Clean Carfax, This has been my personal, family, everyday vehicle... More
NAVIGATION, SRT-8, FREE 1 YEAR WARRANTY. The 2008 Dodge Challenger SRT8 is exactly what a modern version of an old muscle car icon should... More
2008 Dodge Challenger SRT8 6.1 HEMI First Edition. 2310/6400 garage kept in Hawaii. Excellent condition, like new.... More
2008 Dodge Sprinter 2500 144" wb High Top cargo van (VIN: WD0PE745185338544), arctic white ext. with black fabric seats, 116,000 original miles, 5-spd. auto... More


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New voices, big names and the best writing around
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Shilrley Knight, Brian Murray, Sam Waterston, et al. to Star in Simon Gray's The Old Masters
Andy Propst • Connecticut • Nov 17, 2010
The play takes place in Italy in 1937 and centers on two aging lions -- one an art historian (Waterston) and one an art dealer (Murray) -- who are jousting over the value of art and money.
Gray's other plays includes Quartermaine's Terms and The Common Pursuit.
For additional information, visit: www.longwharf.org.


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Jacksonville 67
(9-3, 3-0 A-Sun)
Campbell 65
(7-5, 1-2 A-Sun)
7:30 PM ET, January 3, 2011
Pope Convocation Center, Buies Creek, North Carolina
Top Performers
Jacksonville: R. Powell 14 Pts, 3 Reb, 5 Ast, 3 Stl
Campbell: L. Merthie 14 Pts, 3 Reb, 4 Ast, 1 Stl
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Engagement with patients in healthcare is something that we have heard so much about in the last couple of years, and really not very different from opening people up to conversations and education at a conference. The focus we hear so much about has been clinical engagement, making sure that patients understand their health condition and how to best manage it. While no doubt that this is important, what should not be overlooked is financial engagement, particularly when it comes to the financial health of a physician practice.
According to an annual survey by the American College of Healthcare Executives, financial challenges ranked at the top of the list of worrisome issues for hospital CEOs. Not surprisingly, anxiety about money is also a key concern among Americans. A 2013 study reported that 69 percent of participants cited money as a top stressor. Practices must engage in thoughtful patient education and communication at every point in the revenue cycle – before the patient arrives, with them during the visit, and even after they have left and returned home.
Eliminate the anxiety and confusion not only about your patients' health, but about their financial obligation as well as protecting your business' bottom line by following these simple steps:
Start with eligibility checks (http://www.clinicspectrum.com/
Many patients are unaware of costs for missed appointments. Automated appointment scheduling and follow-ups (http://www.clinicspectrum.com/
If patients do leave an appointment without paying, have auto collection (http://www.clinicspectrum.com/
Remember, engagement and education is the key. Start with advising your patients to ease anxiety and worry, and you will best enable your practice for financial success.
Vishal Gandhi
Vishal Gandhi