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Anti-Semitic attacks in Russia have remained rare in 2011 and 2012, even as anti-Muslim vitriol spread, according to a new report by a Russian-Jewish group.
"During the reviewed period, the number of attacks of anti-Semitic character in Russia has remained relatively low," according to the report published last week by the Euro-Asian Jewish Congress.
The report lists five physical assaults and 38 instances of anti-Semitic vandalism. The report's authors wrote that the low level of anti-Semitic attacks correlates with an increase in anti-Muslim vitriol, connected to religious tensions in the country's south.
RIA Novosti, the Russian news service, quotes the report's authors as saying that "anti-Muslim sentiments have fuelled a renewed interest in Israel as a country combating aggressive Islam."
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Russian FM Lavrov met in Vienna with Iran's Zarif in an unsuccessful bid to break a deadlock in nuclear talks.
When it comes down to it, it's really about the milk. Minister Ariel just cut the price by nearly 5 percent.
The IDF plans to form a new elite commando unit.
Israeli leaders and families of fallen IDF soldiers gather to mark one year since Operation Protective Edge in Gaza.
Tel Aviv has closed a deal to build its Light Rail with a Chinese firm that is doing business with Iran.
F.A.O. Schwarz is closing its iconic flagship store on NYC's Fifth Avenue due to rising rent prices.
Some Chareidi Jews wore sackcloth (and probably ashes) yesterday, while praying at the Kotel on the 17th of Tammuz, a fast day.
The Shin Bet arrested six Negev Bedouin as budding members of a new ISIS terror cell.
The EU is warned that terrorists infiltrating among migrants via the Mediterranean Sea.
"Unfortunately, there are those who seek to exploit the sanctity of Ramadan, and distort its meaning in favor of … terrorism."
In his first public comments following the tenure extension crisis, Rabbi Riskin delivered up some harsh criticism of the Chief Rabbinate.
Instead of accepting reality, the President is trying to hold on to an illusion.
He wants to show everything is "business as usual," which everyone knows is not.
The Palestinian Authority Jawwal mobile phone company is back in business in Gaza after Hamas allowed it to resume operations following last week's forced shutdown. Hamas claimed that Jawwal, part of the Paltel conglomerate run b one of Mahmoud Abbas' closest confidantes, owed taxes. The terrorist organization did not explain why it was allowing Jawaal […]
Jordanian authorities seized 100 pounds of explosives carried by a member of an Iranian-backed group.
Police closed in on a ring of Israeli and Palestinian Authority Arabs who smuggled eggs and sold to supermarkets in urban centers in Israel. The gang raked in more than $2.5 million a year in the operation that stamped the eggs with forged approval. Police investigator Shai Kovnator noted, "The phenomenon of smuggling eggs from […]
More than 20 cars and buildings in a Jewish community in north London were vandalized with swastikas. The Nazi symbol was drawn on approximately 27 cars in the Osbaldeston Road area of Stoke Newington on Sunday night, The Daily Mail reported. An unnamed 32-year-old man was arrested in connection with the vandalism Tuesday. The neighborhood […]
New York State Assemblyman Dov Hikind called on the Jewish community to attend the funeral of an assassinated New York police officer. "The brave men and women of the NYPD risk their lives every day to protect us. We value them and stand with them," Hikind, a Democrat who represents Brooklyn, said in a statement […]
"Move Jew" scrawled on a Philadelphia home and slurs written on a synagogue and 10 garages in Chicago.
The Nazis nearly destroyed the 17th synagogue.
Cuba has "the largest pool of untapped baseball talent in the world, and Major League Baseball may tap and leave Cuba dry.
Someone is finally waking up.
Argentina's president Christina Fernandez has accepted an official Jewish godson for the first time in the country's history to help counter legend of death to a seventh son. She described in seven tweets her meeting with her new godson, Yair Tawil, a member of a Chabad-Lubavitch family. He was adopted as a godson under a […]
A fundraising campaign started quietly by two first graders two years ago to help find a cure for a rare genetic disease just passed the $1 million mark.
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Night of the Jaguarby Michael Gruber
Synopses & Reviews
Publisher Comments:
Science and mysticism, nature and greed collide in this mind-bending, compulsively readable thriller from the author of Tropic of Night and Valley of Bones, hailed by the Washington Post as "miracles of intelligent fiction...among the essential novels of recent years."
Deep in the jungles of Colombia, an American priest is shot dead in his makeshift church. A few weeks later an Indian shaman called Moie arrives in south Florida, armed only with a bag of totems and the fearsome power of Jaguar, his god. In Miami, retired detective Jimmy Paz, his wife, and his seven-year-old daughter are plagued by dreams of giant jungle cats that haunt both their sleeping and waking hours.
When affluent Miami businessmen begin to die in gruesome fashion, the local police are baffled by the lack of clues — other than the massive, catlike footprints that appear at the scene of each murder. They turn to Paz, famous throughout the city for cracking open two previous, impossible-to-solve cases, and for reasons he doesn't dare share, he agrees to come out of his self-imposed retirement to track the killer.
As Paz investigates, Moie finds refuge with a group of ecologically minded activists who treat the strange little man as a pet until they find out exactly what mission brought him to the United States and that it's somehow connected to the grisly murders that are occurring with frightening regularity. The deeper Paz digs into the case, the closer to home the danger gets: his investigation opens the door to his mysterious and shocking past and he slowly begins to realize that the dreams he and his family are having could mean the death of his beloved daughter. To save her life — and his own — he must reach into the deepest corners of his soul and find the strength to hold fast against the irresistible pull of the spirit world.
"Gruber's highly entertaining supernatural thriller completes the trilogy that began with Tropic of Night and Valley of Bones. All feature Miami cop Jimmy Paz, though the real star of this outing is the supposedly dull-witted Jenny Simpson, a gofer for the Forest Planet Alliance. When someone starts murdering Cuban-American businessmen in grisly fashion, suspicion falls on Moie, an Indian from a remote area of Colombia the victims had plans to develop. But how could the tiny Indian leave footprint evidence indicating he weighs over 450 pounds? Summoned out of retirement, Jimmy takes on the case, though he and his seven-year-old daughter, Amelia, are soon troubled by dreams of a jaguar with evil designs on Amelia. Every time Moie glides onto the page, the book shines, but it's Jenny, helping to shelter Moie, who steals the show (e.g., she's baffled that her boss would have a wife, Portia, named after a car). Hotly spiced with hit men and guns, demon gods and piranhas, this one offers more social satire than its predecessors, mostly at the expense of do-gooder environmentalists. 3-city author tour. (Apr.)" Publishers Weekly (Copyright Reed Business Information, Inc.)
"Unlike most writers in this genre, Gruber gives more to ponder than intriguing clues to the identity and motive of the killer...and he does it with prose that is efficient yet rich and hip." Oregonian
"When Gruber explores the religious rites and culture of Santeria and a South American shaman named Moie, he's at his gripping best." Booklist
"Night of the Jaguar remains that rarest of creatures: superior entertainment that raises sincere, provocative questions of intellect and faith." Seattle Times
"For those who haven't yet read his novels, Michael Gruber's Jimmy Paz trilogy is like settling down with a Gabriel Garcia Marquez novel...if it was rewritten by James M. Cain." Denver Post
"Like settling down with a Gabriel Garcia Marquez novel—if it was rewritten by James M. Cain."
Michael Grubers Night of the Jaguar—like his earlier novels featuring
As a Miami Homicide Detective, Jimmy Paz saw terrible things that defied rationality. Now retired, he's put the darkness behind him. But suddenly he, his wife, and their young daughter are being haunted by horrific dreams—terrifying visions of a giant jungle cat. And when affluent Miami businessmen begin dying gruesomely in their fortress-like homes—with the footprints of a massive animal found at the crime scenes—the baffled police must turn to Paz, who has experience with the impossible. Paz cannot refuse, for he's tied to this case by a shocking secret from his past. And what he loves most may be the next thing devoured in this nightmare of carnage and sacrifice.
About the Author
Michael Gruber has a Ph.D. in marine biology from the University of Miami. He lives in Seattle, Washington, and is currently at work on a new novel.
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Courtney Stodden at her home in the Hollywood Hills. (January 31, 2013) -Photo: Glen McCurtayne/Coleman-Rayner
This is completely and utterly ridiculous.
you are right. her udders must be huge to need that kind of padding.
at least she put some shorts on.
thats my dog-walking outfit too
I see a cow and a hairless mole rat. Where's the dog?
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rustic+glamour all in one!
handmade, leather, weaving what else you can ask for? this is very charming!
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Kashkari defies GOP's low expectations
He'll still lose, but governor's candidate soared in debate
SACRAMENTO "When one's expectations are reduced to zero, one really appreciates everything one does have," the physicist Stephen Hawking once said. Those words jumped out Thursday night, as I watched the one and only California gubernatorial debate pitting Democratic Gov. Jerry Brown against Republican political rival Neel Kashkari.
Republicans have zero expectations for winning the race. In fact, Kashkari's only selling point early on was that he is not Tim Donnelly, the loose-lipped conservative Assemblyman that GOP leaders feared would embarrass them at some point during a long campaign. Bullet dodged and expectations met.
But a funny thing happened on the way to the still-likely blowout. Kashkari, despite polls showing that few Californians even have an opinion of him, is running a dogged campaign that is spotlighting some sensible issues. And he's going a step further — clearly explaining why GOP-oriented policies offer hope to people who rarely vote Republican.
During the debate, Brown — as expected — centered his arguments on a California comeback, given the newly balanced budget following the 2012 passage of Proposition 30 tax increases. He touted an expanded minimum wage and the state's newfound momentum. "A lot of people forget the mess California was in just four years ago," he said.
In response, Kashkari focused on the state's highest-in-the-nation poverty rates, on businesses that are fleeing and on high unemployment rates. He pledged to "rebuild the middle class" and to improve California's low ratings in school performance and job creation. He rejected Brown's "incremental" approach toward turning around the state.
With the debate focused heavily on economic issues, it's no surprise that California-based electric-car manufacturer Tesla's announcement earlier Thursday that it was opening its massive new battery plant at a site outside of Reno, Nev., was a major point of contention.
"Governor Brown frequently said businesses come and go. It's not businesses coming and going. It's Tesla. It's Toyota. It's Schwab. It's Nestle. On and on and they're all going," Kashkari said. "Governor Brown has said we need CEQA reform, the environmental laws that are stymying business investment, and then you threw in the towel … so instead you try to get one-off deals to big companies that hire high-priced lobbyists."
I'm glad he made the point about the need to improve the economic situation for all businesses, and not just tout special deals for those politically well-connected companies.
Kashkari said the anti-global-warming cap-and-trade program that Brown champions will — according to state officials — boost gasoline prices. Brown called such claims "scare tactics" and said they were of the same sort used by automobile companies to oppose California's past efforts to boost miles-per-gallon ratings.
Kashkari turned even unrelated questions back to the governor's decision last Friday to appeal the Vergara decision, in which a Los Angeles Superior Court judge tossed out the state's system of public-school job protections as unconstitutional because they make it nearly impossible for school districts to fire bad teachers. Brown said he has expanded funding for public schools, while Kashkari admonished Brown for siding with the teachers' unions in a case that could have helped the neediest students.


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Saturday, December 26, 2009, 1:00pm
Redskins TE Todd Yoder (toe probable) took reps Friday.
Thursday, December 24, 2009, 6:28pm
Redskins TE Todd Yoder (toe) took reps Thursday.
Friday, November 27, 2009, 6:51pm
Redskins TE Todd Yoder (foot questionable) was limited at practice Friday.
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Doctor insights on:
Watery Discharge Third Trimester
Discharge with yellowish green tint during third trimester of pregnancy means?
Time to call OB: Suspicious for presence of an infection. Might be nothing, but should ask your OB. He/she may want to do an exam and microscopic evaluation of discharge to be certain nothing concerning.. ...Read moreGet help from a doctor now ›
Discharge (Definition)
Discharge can be a noun or a verb; it has multiple meanings in physics, chemistry, military, and legal usage. The most common medical meaning is a substance that is being excreted. Examples: pus is the discharge from a pimple; a vaginal discharge can mean infection; an ear discharge can mean an infection of the outer ear tract; a nasal discharge ...Read more
What is the brown discharge in third trimester my mucus plug already came down 1 wk ago?
Early labor signal?: Old blood appears brownish. Did your OB examine you recently? Did you have intercourse? Is it still there, more profuse, reddish? Are you having contractions, pressure or pain in the pelvis? These are some questions you will be asked by your OB or his associate. Discharge can herald labor. A third trimester baby can have risks if born before term. So most obs would want to evaluate or speak to you. ...Read moreGet help from a doctor now ›
Is white discharge normal in the 3rd trimester?
Yes: Vaginal discharge changes in the 3rd trimester. It can get thick and white or thin and watery. White discharge is usually normal, however, if it is clumpy or accompanied by itching, pain, or a fishy odor it may be a sign of a yeast or bacterial infection. ...Read moreGet help from a doctor now ›
Is it normal to have brown discharge during the early 3rd trimester?
Not normal: Please call your OB as you may have a vaginal infection, but u need to make sure your cervix is not starting to open or nothing bad is going on with the placenta your OB can do an exam and an ultrasound and vaginal cultures. ...Read moreGet help from a doctor now ›
Is it normal to have wet underwear in the third trimester?
Yes: The mucous discharge in the third trimester increases. It is also normal to leak small amounts of urine. If the discharge is heavy your should be checked for vaginal infections and to make sure you are not leaking amniotic fluid. ...Read moreGet help from a doctor now ›
Third trimester, what allergy medicines can I use? Cat allergy runny nose, and itchy rash.
OTC: Otc antihistamines are considered category b for pregnancy. The only rx nasal spray in this category is rhinocort aqua. ...Read moreGet help from a doctor now ›
Is it normal for your vagina to smell like your going to start your period at the end of your third trimester?
Vaginal odor: There are several causes of bad smelling vaginal discharge and testing is needed to determine the cause and treatment. The most likely is bacterial vaginosis. Bacterial vaginosis is an overgrowth of normal vaginal bacteria. It causes a watery discharge with a fishy odor. It is not sexually transmitted and your partner does not require treatment. It is treated with antibiotics. ...Read moreGet help from a doctor now ›
How soon will symptoms of listeria appear? I ate some recalled cheese and within 12 hours was nauseated. I am currently in my third trimester.
Listeria: The incubation period for Listeria gastroenteritis is substantially shorter than other gastrointestinal illnesses, mean incubation period is 24 hours (range 6 hours to 10 days). Common symptoms include fever, watery diarrhea, nausea, vomiting, headache, and pains in joints and muscles. You should see you doctor if you have above symptoms and have blood and stool cultures performed ...Read moreGet help from a doctor now ›
In my third trimester just started my seventh month three weeks ago and now I'm leaking a grayish white mucous and I'm wondering what it means?
Get it checked: An increased discharge in the third trimester may be normal but it can also be a sign of an infection or ruptured membranes. Its best to have it checked out by your OB. As your pregnancy progresses and the uterus enlarges, blood flow to the mucus membranes of the vagina and cervix increase causing more discharge. ...Read moreGet help from a doctor now ›
Is it normal to have clear fluid leaking from my vagina in the third trimester?
Yes: There is more discharge as the pregnancy progresses and many women find they are more comfortable wearing a panty shield for the last few months. If you think you could have broken your water, you should see your doctor. ...Read moreGet help from a doctor now ›
Drainage (Definition)
Fluid coming out of an open area or wound. This can be infected ...Read more
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- Brown discharge during third trimester
- Light brown discharge during third trimester
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- White discharge during pregnancy in third trimester
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- Edward Aschoff
Jawon Pass closing in on decision
5hDerek Tyson
You have questions? These Power 5 teams have answers
4dTravis Haney
Former head coaches embrace roles as SEC coordinators
4dGreg Ostendorf
The Opening Hot Board
4dGerry Hamilton
Alabama breakout candidate: TE O.J. Howard
5dAlex Scarborough
Ultimate SEC road trip: Week 7
5dAlex Scarborough
Scout's Take: DE Quinnen Williams to Alabama
5dCraig Haubert
Alabama breakout candidate: LB Reuben Foster
6dAlex Scarborough
Did SEC SIDs get their conference championship game right?
6dEdward Aschoff and Alex Scarborough
Early Offer: ESPN 300 DE Xavier Kelly narrows list
6dJeremy Crabtree
Haubert: The Opening scouting report
6dCraig Haubert
Ultimate SEC road trip: Week 6
6dAlex Scarborough and Greg Ostendorf
Watch J.J. Watt tackle a fan disrupting the Zac Brown Band
6dTania Ganguli
Alabama breakout candidate: WR ArDarius Stewart
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Best and worst of the SEC bowls


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STAGE TUBE: Dat Phan Performs On Last Comic Standing
Dat Phan appeared on Last Comic Standing.
From www.datphan.com: Dat Phan is the Original Winner of NBC's Last Comic Standing, and is a Headlining Comedian touring live across the U.S. He has made numerous TV and Movie appearances including "The Tonight Show with Jay Leno", "The Family Guy" voiceover, "Cellular", and "The Tyra Banks Show". The DVD "Dat Phan Live" was released in January 2010 and is available from Amazon.com. CD "You Touch, You Buy" is now available on Itunes. Preproduction on a movie titled "Yellow Fever" is in the works.
Dat was born in Saigon, Vietnam and grew up struggling and poor in San Diego, CA. His culturally insightful comedy inspects ridiculous stereotypes, and shares his experience of being a regular American guy with a Vietnamese heritage. He has been included in The Smithsonian Institution's exhibition of The Top 10 Most Influential Vietnamese-American Individuals.
More info available at: www.datphan.com or: http://www.facebook.com/datphancomedian
Dat Phan's mission is to bring a more positive portrayal of Asian-Americans to mainstream entertainment and Hollywood. "We want to be seen as more than just martial artists, or bad stereotype token roles in American TV & Movies."
Dat Phan is also available for corporate or private performances. He has performed at countless Comedy Clubs, Universities & Colleges, Casinos, and Corporate events. Notably: Harvard Law, Sacramento Asian Chamber of Commerce, Penn State, Foxwoods, and the U.S. Marine Corps to name a few.
About Author
- STAGE TUBE: Watch Blooper Real from Season 4 of HBO's GAME OF THRONES!
- STAGE TUBE: Idina Menzel, Glom Gazingo Bury the Hatchet at Oscars
- STAGE TUBE: John Legend, Common Perform 'Glory' from SELMA at Oscars
- STAGE TUBE: Jennifer Hudson Pays Tribute to Those Lost with Shaiman, Wittman Song
- STAGE TUBE: Rita Ora Performs 'Grateful' from BEYOND THE LIGHTS at Oscars
- STAGE TUBE: Neil Patrick Harris Strips Down in Ode to BIRDMAN, WHIPLASH
- STAGE TUBE: Tim McGraw Pays Tribute to Glen Campbell with 'I'm Not Gonna Miss You' at Oscars
- STAGE TUBE: The Lonely Island, Tegan and Sara Perform 'Everything Is Awesome' at Oscars
- STAGE TUBE: Adam Levine, Maroon 5 Sing Nominated Song 'Lost Stars' from BEGIN AGAIN
- STAGE TUBE: New Clip from Upcoming Season of Fox's HELL'S KITCHEN!


text: Our Lady of Guadalupe Catholic Church 1003 N. 6th St., Carrizo Springs TX Fr. Jerzy Krzywda, PastorFr. Francisco Quiroz VicarDeacon Jose F. Perez Phone:(830) 876-2239Fax:(830) 876-5023Email:firstname.lastname@example.com: Office Hours:Monday-Friday 8:ooam-5:oopm Mass Schedule:Saturday 6:00pm (Español) Sunday 9:00am(Bilingual) & 11:00 am (English)Monday to Wednesday 8:00am (Bilingual) Thursday and Friday 6:00pm (Bilingual) More Pictures Confessions: 30 Minutes before mass, by appointment, Sunday during Holy Mass 9:00am and 11:00am (Convent) Saturday 5:00-6:00 pm (Church) Map / Directions Matrimony:Should be scheduled at least six (6) months in advance with Pastor Quinceañeras:Should be scheduled at least six (6) months in advance with Pastor More info Parish Secretary: Lisa S. Jaime Bookkeeper: Estella Arce Custodian: Ramon B Glavan CCD Coordinator: Tina Vargas (830) 876-0153 The Vatican United States Conference of Catholic BishopsTexas Catholic Conference Diocese of Laredo KHOY 88.1 Radio Catholic Social Services


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Asthma Health Center
Seasonal Asthma Directory
Asthma may be worse in certain kinds of weather: some people may experience heightened symptoms in hot, humid summers while others suffer in the cold, dry winters. Still others might find their asthma worst in the spring when flowers start blooming. Seasonal allergy can all but ruin a normally fun time of year. Learn how to control seasonal asthma symptoms in all kinds of weather.
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This family space was invigorated with new fixtures, mixed metals, and some good old-fashioned rearranging.
2009 Kips Bay Show House - William T. Georgis's Safe Room
"I wanted to make it a sort of all-in-one room so that you could do everything in this room. You could sit; you could work on your computer; you could watch television. To me it would be your ideal one-bedroom apartment in a very grand space, so the challenge is to make a space like this inviting and comfortable for one person as well as a lot of people." -Bunny Williams
See more photos of Bunny Williams' amazing design here.
2009 Kips Bay Show House - Chris Coleman's Modern Media Room


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Are you Rudi Bao?Claim your profile
Publications (10)79.85 Total impact
- SourceAvailable from: cancerres.aacrjournals.org[Show abstract] [Hide abstract]
ABSTRACT: Animal models of ovarian cancer are crucial for understanding the pathogenesis of the disease and for testing new treatment strategies. A model of ovarian carcinogenesis in the rat was modified and improved to yield ovarian preneoplastic and neoplastic lesions that pathogenetically resemble human ovarian cancer. A significantly lower dose (2 to 5 mug per ovary) of 7,12-dimethylbenz(a)anthracene (DMBA) was applied to the one ovary to maximally preserve its structural integrity. DMBA-induced mutagenesis was additionally combined with repetitive gonadotropin hormone stimulation to induce multiple cycles of active proliferation of the ovarian surface epithelium. Animals were treated in three arms of different doses of DMBA alone or followed by hormone administration. Comparison of the DMBA-treated ovaries with the contralateral control organs revealed the presence of epithelial cell origin lesions at morphologically distinct stages of preneoplasia and neoplasia. Their histopathology and path of dissemination to other organs are very similar to human ovarian cancer. Hormone cotreatment led to an increased lesion severity, indicating that gonadotropins may promote ovarian cancer progression. Point mutations in the Tp53 and Ki-Ras genes were detected that are also characteristic of human ovarian carcinomas. Additionally, an overexpression of estrogen and progesterone receptors was observed in preneoplastic and early neoplastic lesions, suggesting a role of these receptors in ovarian cancer development. These data indicate that this DMBA animal model gives rise to ovarian lesions that closely resemble human ovarian cancer and it is adequate for additional studies on the mechanisms of the disease and its clinical management.Cancer Research 11/2004; 64(22):8177-83. DOI:10.1158/0008-5472.CAN-04-1702
Article: Anomalous expression of epithelial differentiation-determining GATA factors in ovarian tumorigenesis[Show abstract] [Hide abstract]
ABSTRACT: Tumor cells often appear in a deviant differentiated stage, and dedifferentiation is a hallmark of malignancy; however, the causative mechanism of the global changes in dedifferentiation is not understood. The GATA transcription factors function in cell lineage specification during embryonic development and organ formation. The transcriptional targets of the GATA factors in early embryonic development include Disabled-2 and collagen IV, markers for epithelial lineages. GATA-4 and GATA-6 are expressed strongly and are localized in the nucleus in ovarian surface epithelial cells in tissues or primary cell cultures. By immunohistochemistry, we found that 82% of the 50 tumors analyzed had lost GATA-6 function, either by a complete absence of expression or by cytoplasmic mislocalization. The frequent loss of GATA-6 was also confirmed in a panel of ovarian surface epithelial and tumor cell lines. Although GATA-4 is absent only in a small percentage (14%) of ovarian tumors, it is lost in the majority of established cell lines in culture. The loss of GATA-6 correlates with the loss of Disabled-2, collagen IV, and laminin, markers for epithelial cell types. Loss of GATA factors was also found in an in vitro model for spontaneous transformation of rat ovarian epithelial cells. Repression of GATA-6 by small interfering (si)RNA approach in cultured cells leads to dedifferentiation as indicated by the loss of Disabled-2 and laminin expression. Restoration of GATA factors expression by ectopic transfection suppresses cell growth and is incompatible with the maintenance of the cells in culture. However, restoration of GATA-4 and GATA-6 expression is not able to induce expression of endogenous Disabled-2 in tumor cells, suggesting that the loss of GATA factors and dedifferentiation are irreversible processes. In conclusion, we observed the inappropriate expression and cellular localization of the GATA transcription factors in ovarian tumor tissues and cancer cell lines, and we have demonstrated that down-regulation of GATA factor expression leads to dedifferentiation. We propose that alterations of GATA transcription factor expression and aberrant nucleocytoplasmic localization may contribute to the anomalous epithelial dedifferentiation of the ovarian tumor cells.Cancer Research 09/2003; 63(16):4967-77.
Article: Generation of tumors in transgenic mice expressing the SV40 T antigen under the control of ovarian-specific promoter 1[Show abstract] [Hide abstract]
ABSTRACT: The ovarian-specific promoter, OSP-1, which was cloned from the transcript of a rat retrovirus-like element specifically expressed in ovarian tissue, was tested for its ability to drive ovary-specific transcription in transgenic mice. Transgenic mice were generated with the lacZ reporter gene (OSP-lacZ) or the early region of SV40 virus (OSP-TAg) placed under the control of the OSP-1 promoter. OSP-lacZ and OSP-TAg transgenic animals were examined, respectively, for the expression of lacZ (OSP-lacZ) or the development of tumors (OSP-TAg). The expression of lacZ in the resulting OSP-lacZ mice was restricted to the ovary as determined by X-gal staining of multiple organs. Immunohistochemical detection of beta-galactosidase showed lacZ expression mainly in the granulosa cells and ovarian surface epithelial cells. OSP-TAg mice developed tumors in a variety of tissues, including unilateral granulosa cell tumors in two of three female founder mice. In the contralateral ovary of one mouse with a granulosa cell tumor, there were alterations in the ovarian surface epithelial cells suggestive of preneoplasia. Although the OSP-1 promoter was able to restrict reporter gene expression to the ovary in transgenic mice, the expression of TAg in the OSP-TAg mice resulted in ovarian tumors as well as tumors in numerous other organs. This indicated that although transcription from the OSP-1 promoter occurs predominantly in the ovary, this promoter is sufficiently leaky in cells in other tissues to permit their tumorigenic conversion by SV40 TAg.Journal of the Society for Gynecologic Investigation 06/2003; 10(4):244-50. DOI:10.1016/S1071-5576(03)00073-X
Article: Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines.[Show abstract] [Hide abstract]
ABSTRACT: Ovarian cancer is the leading cause of death among women from gynecological malignancies inthe United States. Resistance to the chemotherapeutic agent cisplatin isa major limitation for the successful treatment of ovarian cancer. In an effort to overcome the cisplatin resistance problem in ovarian cancer treatment, we have sought to enhance cisplatin cytotoxicity by perturbing the nucleotide excision repair (NER) pathway. The NER pathway is responsible for repairing cisplatin bound to DNA. Expression of one of the NER components, ERCC1, is correlated with cisplatin drug resistance. Hence, we targeted ERCC1 by antisense RNA methodologies, and we show that we could sensitize a relatively sensitive A2780 cell line and also the highly resistant OVCAR10 cell line to cisplatin by expressing antisense ERCC1 RNA in them as measured with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. The A2780 cell lines expressing antisense ERCC1 had 1.9-8.1-fold enhancements in cisplatin sensitivity. The OVCAR10 antisense ERCC1 cell lines had IC(50) values ranging from 2.28 microM to 2.7 microM cisplatin as compared with 9.52 micro M for control OVCAR10 cells. The OVCAR10 antisense ERCC1 cells also show reduced DNA-damage repair capacity as assessed by host cell reactivation. Furthermore, immunocompromised mice transplanted with the antisense cell lines survived longer than the mice bearing control cells after response to cisplatin treatment. These data suggest that it is possible to substantially enhance the cisplatin cytotoxicity by disturbing the NER pathway in cisplatin-resistant cell lines and to enhance the survival capacity of mice in an ovarian cancer xenograft model.Cancer Research 04/2003; 63(6):1311-6.
Article: Female mice chimeric for expression of the simian virus 40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer.[Show abstract] [Hide abstract]
ABSTRACT: In women, >80% of malignant ovarian tumors are of epithelial origin. Early detection of these tumors is very challenging,and extensive i.p. dissemination is common by the time of diagnosis. The lack of adequate geneticmouse models of ovarian carcinomas significantly delays advances in early detection and treatment. We report that female transgenic mice expressing the transforming region of SV40 under control of the Mullerian inhibitory substance type II receptor gene promoter develop bilateral ovarian tumors in approximately 50% of cases. Histologically, these tumors are poorly differentiated carcinomas with occasional cysts and papillary structures present at the surface of the ovary. These tumors disseminate i.p., invade omentum, and form ascites as do human ovarian carcinomas. The epithelial origin of these tumors is supported by detection of cytokeratins 8 and 19, and the absence of alpha-inhibin, a protein characteristically expressed in normal granulosa cells and most granulosa cell tumors. Cell lines derived from the ascites exhibit the properties of epithelial ovarian cancer, such as anchorage-independent growth, tumorigenicity in immunocompromised mice, expression of epithelial cell markers, and organotropic implantation. The availability of a transgenic mouse model of disseminated ovarian carcinoma and respective cell lines should advance our understanding of this neoplasm, and serve as a useful tool for the evaluation of emerging detection and treatment strategies.Cancer Research 03/2003; 63(6):1389-97.
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ABSTRACT: Survivin, a member of the IAP (inhibitor of apoptosis) gene family, appears to be overexpressed in common cancers but not in corresponding normal adult tissues. To investigate whether the survivin promoter controls cancer cell-specific gene expression, we determined whether the survivin gene promoter could regulate reporter gene expression in cancer cell lines and xenografts. Survivin protein levels were determined in human and murine cancer cell lines and in normal tissues of adult C57BL/6 mice by Western blot analysis. A reporter construct in which a portion of the survivin gene promoter was used to drive transcription of a human secreted alkaline phosphatase (SEAP) gene was transiently transfected into cancer cells, and promoter activity was extrapolated from SEAP activity. A2780 human ovarian cancer cells were transfected with this construct, and stable transfectants were injected into the intrabursal ovarian space of immunodeficient mice. Tumor growth was monitored, and plasma SEAP levels were used as a measure of survivin promoter activity in vivo. Survivin protein was detected in all cancer cell lines examined but not in most normal adult mouse tissues. After transfection, the survivin promoter was more active in all cancer cell lines than in normal ovarian surface epithelial cells or mouse 3T3 cells. After 0.8 x 10(6) stable transfectant cells were injected into the intrabursal cavity of mouse ovaries, plasma SEAP activity was detected within 24 hours, and the activity increased with time and tumor growth. Transfection experiments indicate that survivin protein expression in cancer tissue appears to be regulated, at least in part, transcriptionally. Thus, the survivin promoter may be useful in controlling gene expression in cancer cells.JNCI Journal of the National Cancer Institute 05/2002; 94(7):522-8.
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ABSTRACT: The "suicide" gene therapy of cancer using promoters such as cytomegalovirus could cause severe toxicity to normal tissues due to a lack of specificity of prodrug activation. Therefore, we investigated gene therapy of ovarian cancer using ovarian-specific promoter (OSP1) to limit the synthesis of the prodrug activating enzyme HSVtk to ovarian cancer cells. The HSVtk expressing plasmid pOSP1-HSVtk was created and transfected into an ovarian cancer cell line OVCAR3. The ganciclovir (GCV) sensitivity of the stable transfectants was evaluated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Tissue specificity of this promoter was evaluated by comparing the sensitivity to GCV between ovarian and nonovarian cancer cell lines after they were transfected with pOSP1-HSVtk. One transfectant sensitive to GCV was implanted intraperitoneally to immunocompromised mice which were treated subsequently with GCV. Furthermore, this ovarian cancer survival model was used to evaluate the in vivo efficacy of cationic lipid mediated pOSP1-HSVtk gene delivery followed by GCV treatment. Stable transfectants of OVCAR3 cells bearing OSP1-HSVtk became more sensitive to GCV treatment compared to the parental cell line and vector transfected OVCAR3 cell line. OSP1-HSVtk could specifically sensitize the OVCAR3 ovarian cancer cell line to GCV. SCID mice transplanted with the OVCAR3 transfectant and treated with GCV survived longer than the mice without GCV treatment (P = 0.032). In vivo gene delivery mediated by a cationic lipid (GL67) followed by GCV treatment yielded a longer survival in the OVCAR3 survival model (P = 0.016). The OSP1 promoter can selectively direct suicide gene therapy of ovarian cancer and the in vivo efficacy is improved by using a cationic lipid GL67 as delivery vehicle as opposed to the direct injection of plasmid.Gynecologic Oncology 03/2002; 84(2):228-34. DOI:10.1006/gyno.2001.6490
Article: Oarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element[Show abstract] [Hide abstract]
ABSTRACT: We have isolated 462 bp of sequence termed ovarian-specific promoter 1 (OSP-1) that is part of a retrovirus-like element specifically expressed in the rat ovary. We have evaluated the ability of OSP-1 to activate gene expression in normal and neoplastic cell lines derived from the ovaries of rats and women. We have found that there was marked specificity in the ability of OSP-1 to drive reporter gene expression in an ovarian epithelial cell lineage manner. The expression of herpes simplex virus thymidine kinase (HSV-TK) under OSP-1 control was sufficiently ovarian cancer cell line specific to render ganciclovir approximately 50-fold more toxic in the A2780 human ovarian cancer cell line compared with clones of the HCT-116 and HT-29 colon cancer cell lines. Furthermore, ganciclovir had marked antitumor efficacy in vivo in severe combined immunodeficient mice bearing A2780OSP-1-HSV-TK as a s.c. xenograft. We suggest that these data support the use of OSP-1 as a tool to provide specificity to the gene therapy of ovarian cancer and to drive ovarian-specific oncogene expression for the creation of transgenic mouse models of ovarian cancer.Cancer Research 03/2001; 61(4):1291-5.
Article: Use of a Surrogate Marker (Human Secreted Alkaline Phosphatase) to Monitor in Vivo Tumor Growth and Anticancer Drug Efficacy in Ovarian Cancer Xenografts[Show abstract] [Hide abstract]
ABSTRACT: A limitation to preclinical evaluation of possible anticancer therapy is the objective assessment of efficacy, especially in the presence of small tumor burden or inaccessible disease. This study is designed to test whether human secreted alkaline phosphatase (SEAP) could be used as a soluble marker for in vivo tumor burden. A SEAP expression construct under control of the CMV promoter was created. The SEAP activity in the conditioned medium was evaluated at 24 h and 48 h after the A2780 cell line was transiently transfected with the SEAP vector using Superfect reagent. Stable transfection of A2780 was accomplished by selection of transfectants in G418. SEAP activity of the stable transfectant was determined in conditioned medium and its relationship to tumor cell number was examined. A highly expressing stable transfectant was implanted into immunocompromised mice (2 x 10(6) subcutaneously and 5 x 10(6) intraperitoneally) and peripheral blood was obtained by orbital puncture every 5 days. The relationship between blood SEAP activity and tumor burden was studied. The usefulness of this marker in preclinical assessment of anticancer drug efficacy was evaluated by studying the plasma SEAP activity in xenografted mice treated or not treated with paclitaxel. After transient transfection of the A2780 cell line (5 x 10(5)) with the plasmid, SEAP activity was found in the medium at 24 h (482.0 +/- 2.0 ng/ml) and 48 h (1296.0 +/- 1.0 ng/ml). The in vitro study using a stable transfectant demonstrated that SEAP activity was linearly related to cell numbers (r = 0.99). The in vivo study demonstrated that SEAP was detectable in plasma one day postinjection, long before measurable tumor or detectable intraperitoneal tumor was present. Once detectable SC tumor was present, the SEAP activity correlated well with tumor volume (r = 0. 94-0.97). The plasma SEAP level was reduced after xenografted mice were treated with paclitaxel (20 mg/kg, weekly x5) compared with untreated mice in both SC and IP tumor models (P = 0.05, P = 0.025, respectively). These data suggest that the plasma SEAP activity can be used as an alternative to survival or tumor measurement in evaluating anticancer agents for efficacy, especially in the case of minimal or inaccessible disease.Gynecologic Oncology 10/2000; 78(3 Pt 1):373-9. DOI:10.1006/gyno.2000.5925
Article: LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein.[Show abstract] [Hide abstract]
ABSTRACT: We previously reported cloning the rLot1 gene, and its human homolog (hLOT1), through analysis of differential gene expression in normal and malignant rat ovarian surface epithelial cells. Both human and rat ovarian carcinoma cell lines exhibited lost or decreased expression of this gene. Interestingly, the LOT1 gene localized at band q25 of human chromosome 6 which is a frequent site for LOH in many solid tumors including ovarian cancer. In this report we have further characterized the potential role of LOT1 in malignant transformation and developed evidence that the gene is a novel target of growth factor signaling pathway. Assays using transient transfections showed that LOT1 is a nuclear protein and may act as a transcription factor. In vitro and in vivo studies involving ovarian cancer cell lines revealed that expression of LOT1 is directly associated with inhibition of cellular proliferation and induction of morphological transformations. Additionally, we show that in normal rat ovarian surface epithelial cells Lot1 gene expression is responsive to growth factor stimulation. Its mRNA is strongly down-regulated by epidermal growth factor receptor (EGFR) ligands, namely EGF and TGF-alpha. Blocking the ligand-activated EGFR signal transduction pathway by the specific EGF receptor inhibitor, tyrphostin AG1478, and the MEK inhibitor, PD098059, restores the normal level of Lot1 gene expression. It appears that the regulation of Lot1 gene is unique to these ligands, as well as the growth promoting agent TPA, since other factors either did not affect Lot1 expression, or the effect was modest and transient. Altogether, the results suggest that Lot1 expression is primarily mediated via EGF receptor or a related pathway and it may regulate the growth promoting signals as a zinc-finger motif containing nuclear transcription factor.Oncogene 12/1999; 18(47):6477-87. DOI:10.1038/sj.onc.1203067
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Fox Chase Cancer Center
Philadelphia, PA, United States
- Department of Medical Oncology


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Georgia Perimeter College's 50th and final graduation under the GPC banner will take place Friday, May 8, at 10:30 a.m. at the Georgia World Congress Center. The college expects to become a unit of Georgia State University next January.
With the fiscal year winding down, the city of Covington got word that it is "in good, good financial shape," according to Miller Edwards of Mauldin and Jenkins CPAs, LLC, which presented its audit to the council Monday.
IN BRIEF: Interstate 20 westbound at Salem Road is shut down due to a tractor trailer fire. No injuries are reported. Check back later for more.
As a way to promote downtown businesses and eateries, Main Street Covington is working with area shops and restaurants on "Love for Mom," Day, Saturday, 10 a.m.-2 p.m.
There's nothing a termite likes more than a damp, dark place rich.
The Board of Commissioners is preparing to vote on whether to allow SRG Global to carry out testing around its Covington plant to determine the extent of chemical contamination after a 2013 test revealed trichloroethylene (TCE) in the groundwater.
A new proposal to cap county attorney fees at $800,000 could help bring the county's legal spending within the upper range of other Georgia counties, but it would also be a significant budget increase at a time of severe financial constraints and is already facing pushback from critics.
The strains of '80s and '90s classic rock will be heard over lunch in downtown Covington beginning Thursday, May 7, with the launch of the 25th season of Concerts on the Square.
Superior Court Judge Horace J. Johnson, Jr., Alcovy Judicial Circuit, Covington, became President-Elect of the Council of Superior Court Judges on Friday, and his term will run through April 30, 2016.
One of the first items on Newton County School Superintendent Samantha Fuhrey's agenda for the 2015-16 school year was filling the vacancies led by South Salem and Porterdale elementary schools principals Holly Dubois and Dr. Lizella Dodson, respectively.
Newton County faces some tough decisions for next year's budget with the Sheriff seeking a $6.2 million increase and county employees impatient for raises.
Newton County School System will hold its annual Kindergarten Round-Up during the week of May 4- May 7. Children must be 5 years old by Sept. 1, 2015 (child must have been born on or before September 1, 2010) to register for the 2015-2016 school year. Parents should bring the prospective kindergarten student with them to the roundup so teachers can conduct screenings with the children.
Showers and thunderstorms over the next day or so are expected to give way to sun by Christmas, as the National Weather Center warned of possible hailstorms Tuesday morning.
Oxford is the only city of its kind.
When Rebecca Bates shared the news she had stage two breast cancer in the spring of 2013, her family was worried. For the next year, her husband, Kevin Bates, and children, Gavin and Grace, now 11 and 9 respectively, struggled with their fears as they supported her through chemotherapy and radiation treatments.
A Social Circle man will serve five years of a 20-year sentence in prison after pleading guilty to three counts of child molestation, the Walton County assistant district attorney confirmed Thursday.
County Chairman Keith Ellis presided Wednesday over the groundbreaking ceremony for improvements to the notorious intersection of Georgia Highway 81 and Crowell Road in Porterdale, where cars were lined up 10-deep well after rush hour.
A man was dragged from the bathroom and restrained to the floor, before being shot at a Covington residence Wednesday morning.
In the wake of the recent outbreak of gastroenteritis at Oak Hill Elementary, the Newton County School Board concluded an action needed to disinfect the school during its meeting Tuesday night.
The Covington Police Department is getting even more high tech and started preparing for the future Monday night.
The Georgia State Superintendent's Office released the Georgia College and Career Ready Performance Index, CCRPI, scores for the 2013-2014 school year Tuesday.
Donation boxes in the city of Covington now has to kept to strict guidelines after the city council approved a text amendment to the zoning ordinance regulating unmanned donation boxes Monday.
Update 12/18/2014: Due to inclement weather, the event will be postponed to next Saturday, Dec. 27 at the same time.
The first 2015 Ford F-150 sold in Georgia will be driven in Covington, as Newton County resident Mike Poole made the purchase at Covington Ford.
The City of Covington agreed to purchase a new excavator and trailer during Monday night's public meeting.
Alcovy United Methodist Church is working with the Salvation Army's Toy Drive for the third year, and helped supply toys to those who might otherwise not have anything for Christmas.
A group of concerned citizens spoke up to the Covington Planning and Zoning Department and the Covington City Council, and had their voices heard Monday night.
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Vera Wang
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Vera Wang
Fashion Designer
Vera Ellen Wang (Chinese: 王薇薇; pinyin: Wáng Wēiwei, born June 27, 1949) is an American fashion designer based in New York City and former figure skater. She is known for her wide range of haute couture bridesmaid gowns and wedding gown collections, as well as for her clientele of elite lady figure skaters, designing dresses for competitions and exhibitions. Wikipedia
27th June, 1949, New York, NY
5' 3" (160 cm)
Wedding Dress Designs
Vanessa Hudgens Reveals Whether She Helped Selena Gomez Avoid Justin Bieber at the Met Gala—Watch the Video!


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Everything tagged
Latest from The Spokesman-Review
Bloomsday's Taking Shape Experts Offer Step-By-Step Tips For Getting Ready For The Big Race
March 15, 1998 in City on Page B1 Runners in the YWCA Bloomsday training group stretch their legs before an evening run on Wednesday. Photo by Shawn Jacobson/The Spokesman-Review
Bloomsday Expectations Running Wild Event Official Predicts 65,000 Racers This Year
March 4, 1998 in Nation/World on Page A1 Jerry Kapelke, city maintenance shop foreman, welds the boy runner sculpture back on its base Tuesday. It had been stolen from Riverfront Park. "This one's tough because it's so small," …
Corporate Cup Results
May 7, 1997 in City on Page B1 Want to see how your company's Corporate Cup team placed in Bloomsday's Corporate Cup competition? Interested in the finish times for the top 25 Bloomsday runners in each age group? …
Bloomsday Numbers Off, But Who's Counting? Organizers See Nothing To Suggest Any Serious Problems
May 6, 1997 in Nation/World on Page A1 This year's drop in the number of people entering and finishing Bloomsday doesn't suggest any serious problems for Spokane's annual exercise in sweat and camaraderie, race officials said Monday. It …
Bloomsday Volunteers Looking For Trouble Veteran Problem Solvers Help Ease Confusion For Entrants
May 3, 1997 in Nation/World on Page A1 With pastel balloons following them like shadows, the trouble-shooters inevitably became targets. "Can you help me?" people asked constantly. "Where am I supposed to go?" For several hours, the balloon …
Race Hoopla A Difficult Time For One Family It's Been 5 Years Since Donald Kamp Died
May 3, 1997 in City on Page B1 1. Bloomsday is a tough time of year for Brian Kamp and his family. Photo by Sandra Bancroft-Billings/The Spokesman-Review 2. Jane McDonald helps organize volunteers at Bloomsday registration on Friday. …
First-Run Films Not All Running Movies Will Get You In Bloomsday Mood
May 1, 1997 in Features on Page D1 1. Top: Harrison Ford runs from authorities in "The Fugitive," the film adaptation of the TV series. 2. Middle: Tom Hanks takes off on a three-year jog in the 1994 …
Flexible Routine A Regimen Of Warmup Exercises Will Keep Your Running Machine In Tip-Top Shape For Bloomsday
April 29, 1997 in Features on Page D1 Stretch or die … stretch or die … stretch or die. If only runners would heed physical therapist Chuck Strickell's advice, maybe he could catch his …
Resetting The Pace Some Bloomsday Junkies See Times Skyrocket When They Add Kids, Strollers
April 28, 1997 in Nation/World on Page A5 Many of Bloomsday's competitive runners, such as Tim Thomas, have had to downshift their running times after becoming parents. Photo by Colin Mulvany/The Spokesman-Review
Reaching The Golden Years Of Running Just 149 Bloomies Recorded Times Lower Than Their Ages
April 25, 1997 in City on Page B1 For inspiration, George Boulden, 80, keeps a wall of past race numbers and awards in his basement workout room. Photo by Shawn Jacobson/The Spokesman-Review
Intensity Grows In Boston Marathon Field Strongest In Years As Kenyans, Mexicans Eye Supremacy
April 20, 1997 in Sports on Page C3 The 101st Boston Marathon is being billed as "The Rematch," another confrontation between defending champion Moses Tanui and three-time winner Cosmas Ndeti, both of Kenya. A more appropriate title would …
He Hopes Volunteers Will Roll In Bloomsday Enthusiasts In Wheelchairs Need A Push
April 9, 1997 in City on Page B1 1. John MacBrayne is looking for a partner so he can compete this year. 2. John MacBrayne has collected 14 Bloomsday pins - one for each race he has participated …
Web Page Gives Bloomies Leg Up
April 6, 1997 in City on Page B1 You don't have to leave home this year to register for Bloomsday. For the first time in the race's history, Bloomies can download the registration form from the Internet. The …
20th Bloomsday Comes With Changes
Feb. 29, 1996 in City on Page B1 Bloomsday '96 is more than two months away, but some people are already racing. The Bloomsday staff is off and running to get registration forms out and posters up for …
Pregnant Runner Returns For 24-Hour Marathon
June 24, 1995 in Sports on Page C2 Sue Olsen, the pregnant Burnsville runner whose marathon finish last week received worldwide attention, plans to be at the starting line today for the beginning of the FANS (Family Advocate …
New Guinea Couple Plans To Visit On The Run
March 11, 1995 in City on Page B2 Mike and Angela Baker picked their destinations carefully when they planned their trip around the world this spring. The Bakers, who live in Papua New Guinea, decided to fly to …
Inflation Hits Bloomsday Officials Increase Entry Fee By A Dollar, Hope To Be Part Of Road-Running Championships
March 3, 1995 in Nation/World on Page A1 FOR THE RECORD: (March 7, 1995): This year's Bloomsday poster was designed by artists Ken Spiering and John Mraz. A photo cutline in the paper Friday incompletely listed the artists. …


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- 06/29 Facing the music: Eric Whitacre
- 06/22 Kirill Petrenko to succeed Simon Rattle at the Berlin Philharmonic
- 06/22 James Horner, Film Composer, Dies in Plane Crash
- 06/22 Recognition of Ernest Tomlinson, orchestral composer
- 06/21 R.I.P. Gunther Schuller, Pulitzer-winning jazz and classical musician
- 06/06 Are We All Mistuning Our Instruments, and Can We Blame the Nazis?
- ♬ Special Note: Carla Dirlikov becomes first opera singer to be named to The
President's Committee on the Arts and Humanities' Turnaround Arts
- 06/03 Remembering Margaret Juntwait
- ♬ Special Note: Kansas City Symphony players take Haydn, Mozart to prison
- 05/30 JoAnn Falletta to remain at BPO through 2021
- ♬ Special Note: Daniel Barenboim reveals radical new piano design
- 05/28 UB chamber music series combines classical music, architectural history
- 05/20 Minnesota Orchestra signs deals with Vänskä, musicians
- 05/16 Leif Ove Andsnes: my key to a modern Beethoven
- 05/11 Symphonic diplomacy is goal of Minnesota Orchestra's Cuba trip
- 05/08 How the CSO engineered its turnaround
- 05/05 The little orchestra that leads itself
- 05/04 Eric Jacobsen new music director of Orlando Philharmonic
- 05/04 The Rakes Progress Makes a Brief Visit at the Met
- 05/03 Paul Bryan inducted into the NC Bandmasters Association Hall of Fame
- 04/29 Iconic Portrait of Composer J.S. Bach Returns to Germany
- 04/28 Trumpeter Rolf Smedvig Dies Suddenly
- 04/27 A World of Spanish Songs
- 04/20 Julia Wolfe Wins Music Pulitzer
- 04/15 North Carolina native Caroline Shaw ignores the divides
- 04/14 ECU Chamber Singers win international choral competition
- 04/11 Listen to the Future
- 04/09 Twitter Outrage Takes Toronto, Canceling Two Pianists
- 04/09 Music by living composers is faring well
- 04/02 Vienna Philharmonic will do 3-year residency in Naples
WCPE Home Page
This week Great Sacred Music will feature music by American composers William Billings, Daniel Gawthrop and Morten Lauridsen as we celebrate our nation's independence.
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Our Bach cantata is BWV 88 "Siehe, ich will viel Fischer aussenden" which will be followed by Elinor Remick Warren's "The Harp Weaver".
Our featured work is Horatio Parker's oratorio "Hora Novissima".
Great Sacred Music. The best choirs and organists. Every Sunday morning. 8 until 11 eastern. With your host Rob Kennedy.
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WCPE's 'Preview!'
Sunday July 5th at 6PM EST
This week on WCPE's Preview! we'll hear music of Camille SaintSaens from a brand new disc by the Kansas City Symphony, Michael Stern conducting.
Tara Lynn speaks with Barry Douglas about his latest recording of the works of Brahms for solo piano.
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And trumpeter Paul Merkelo joins Kent Nagano and the Montreal Symphony to play modern French trumpet concertos.
Preview! the best in new classical recordings and arts news each Sunday from 6 to 9 p.m. Eastern Time, on The Classical Station, WCPE.
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Sunday July 5th at 9PM EST
We celebrate American music this weekend on WCPE, so on our next Wavelengths we'll feature Richard Danielpour's Concerto for Orchestra "Zoroastrian Riddles" played by the Pittsburgh Symphony.
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We'll also hear John Alden Carpenter's jazzera ballet Skyscrapers, and two Duets for Violin and Cello by Robert Ashford.
Wavelengths brings you the best in contemporary classical music, Sunday at 9 p.m. Eastern time on The Classical Station, WCPE.
Questions? Comments? Please write to us here:
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Monks and their devotional singing were not heard in Norcia for nearly two hundred years, until 1998 when Friar Cassian Folsom, an American who studied voice at Indiana University, founded a monastery there. Father Cassian recently joined us on Preview! to discuss the monks new album of Marian chant, Benedicta, which was recorded on location at the monastery. Benedicta includes chants that have not been previously recorded, and an original composition by the monks choirmaster.
Please click here to listen to this, and many other Preview Interviews!
WCPE FM, The Classical Station, announces five grants totaling more than $8,000 from its WCPE Education Fund for the 201516 season.
WCPE Education Fund
When your contribution is at least $50.00, you may, in lieu of choosing a gift, designate that 10% of your donation go toward the WCPE Education Fund. Please check the appropriate box in the Secure Pledge Form!
The Metropolitan Opera Announces the 2014-15 Season
The Mets 2014-15 Season Will Feature 26 Operas, Including Three Met Premieres, In Six New Productions and 18 Revivals!
Be sure to sign up for WCPE's 'Crescendo', our Monthly Newsletter!
Online playlists
"What was that beautiful piece of music??" Find out now by browsing through a week's worth of playlists!
Meet the Announcer
Ever wonder what your favorite voice looks like? See photos and read brief biographies of WCPE's announcers!
"Quarter Notes"
WCPE's Member Magazine
Published quarterly, this magazine and listener guide offers featured works and program highlights for the WCPE season to come, plus station news, reviews, interviews and other articles designed to enhance your classical music journey.
Quarter Notes is sent to WCPE members in print version, and members may also choose to view this website's "green" online version. To become a WCPE member (your gift is tax-deductible!) and receive a year's subscription to Quarter Notes, click here.
Donate your car to WCPE!
If your automobile (truck, boat, motorcycle, RV, or aircraft) is no longer of use to you, it can still go a long way as a donation in support of the Great Classical Music you rely on from WCPE. Learn how!
Tell us how you feel about WCPE!
Record your message on the WCPE Listener Comment Line. Please phone (919) 570-0204 and tell us what WCPE means to you.
Find out more about a fun way to support your home for Great Classical Music.
Live Metropolitan Opera Saturday radio broadcasts can be heard on this website. To see the Metropolitan Opera schedule click here.


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Revenge Music: Songs From Season 2, Episode 3, "Confidence"
Ready to pop your collar and bust a move? Check out the latest and greatest songs from this week's episode of Revenge, Season 2, Episode 3! Nothing says "fan-girl" like downloading these bad boys and listening to them on repeat all week, so buy 'em while they're hot!
PS: They're always hot.
1. "I Will Be Back One Day" by Lord Huron
Emily wanders over to The Stowaway to ask Fauxmanda for a favor.
2. "Everything Trying" by Damien Jurado
Jack and Amanda have a late-night bonding session at The Stowaway. Another shot of milk, please!
What did you think of last night's music? Weigh in below!
Wanna share theories with fellow Revenge fans? Join the discussion on our Revenge Facebook page!
Follow @RevengeWetpaint on Twitter
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Public Safety & Justice
Mayors Meet with Obama to Discuss Youth Violence
President Obama and Attorney General Eric Holder met with a group of 18 mayors on Tuesday to discuss strategies to cut down on youth violence, the White House said.
President Obama and Attorney General Eric Holder met with a group of 18 mayors on Tuesday to discuss strategies to cut down on youth violence, the White House said.
Newark's Cory Booker, the Democratic nominee in New Jersey's Senate race was among the attendees, as were Atlanta's Kasim Reed, Philadelphia's Michael Nutter and Washington's Vincent Gray. The meeting comes just a day before the 50th anniversary of Martin Luther King Jr.'s "I Have a Dream" speech and as Obama prepares to deliver his own speech Wednesday to mark the anniversary.
Obama applauded the mayors for their efforts to fight violence in their cities, the White House said, and "solicited their input about proven methods and pledged his administration's partnership."
The president also said he would "continue doing everything in his power to combat gun violence through executive action and to press Congress to pass common-sense reforms like expanding the background check system and cracking down on gun trafficking."
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Real Estate
I Achieved the American Dream — and It Was Awful
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This facility is greatly understaffed. It took 20 minutes for a nurse's aide to respond to my mom's call light. No wound care was provided for my mom's ulcers on her legs. My mom sustained a fall out of bed due to no safety rails on the beds, with this facility knowing that my mom was in a state of delirium. A bed alarm was placed in her bed after she fell. She hit her head when she fell & with...
Tendercare Health Center of Leelanau is an average sized, for profit, nursing home with 72 beds based in Suttons Bay, MI. At last check, the facility had 61 residents indicating that it is 85% occupied which is about average within the state of Michigan. The provider accepts both medicare and medicaid programs, and provides resident counseling services.
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Respite Care
Tendercare Health Center of Leelanau can be found at W 4th St 124. The following is offered: Doctors & Clinics. The entry is present with us since Sep 10, 2010 and was last updated on Nov 14, 2013. In Suttons Bay there are 7 other Doctors & Clinics. An overview can be found here.


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- Elk Ridge Resort jobs
It's Time.. to change your career path from boredinary to the extraordinary! Join our team and learn how to mix work and play. Apply Today!
Located 90km north of Prince Albert, Saskatchewan, Elk Ridge Resort is the province's premiere all season resort. Anchored by a 27-hole championship golf course, Elk Ridge Resort offers four-star accommodation with full amenities including a spa and indoor recreation facility, as well as luxury condominiums, estate lots and a brand new cottage development.Elk Ridge Resort is seeking a full-time Guest Services Agent to work with the high performing team at Saskatchewan's Premiere Resort.
The Guest Services Agent will reside at Elk Ridge Resort and be an energetic and experienced hospitality professional who thrives on customer service excellence. The Guest Services Agent provides exceptional service to guests and potential guests through courteous and professional interaction. Reporting to the Assistant Manager of Guest Services, the Guest Services Agent will work with a dynamic Front Office team.
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World Association for Medical Law
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Briefly: Garage sale to fund memorial for fallen
The Wichita County Sheriff's Office Citizen's Academy Alumni Association Garage Sale will be 7 a.m. to 2 p.m. Saturday. The sale is at the old Koch's Liquor Store at 3124 Seymour Highway in front of Fre-Mar Valley Shopping Center.
Anyone who would like to donate items for the sale should call 940-733-8435 or 940-631-8435.
All proceeds go to build a memorial for fallen deputies and volunteer firefighters of Wichita County.
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The Journal Sentinel Editorial Board's blog on the day's happenings as they happen
Thanks, Badgers
Our congratulations and thanks to the University of Wisconsin men's basketball team for a terrific season and a thrilling ride through the NCAA tournament. That the team fell just short of the championship game is no reflection of the effort, the coaching or the ability of the true student athletes who played tough throughout. Luck does not play everyone the same, and life is not always fair. Thanks again to coach Bo Ryan and all those associated with the team for a great season; here's hoping for another successful run next year. Go, Bucky!
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Creamy Sausage Casserole with Biscuits
Santa Fe Chicken Bread Bowls
Beef Stroganoff Pot Pie
Hungry Boys' Casserole
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For a golden crowning touch, bake biscuits on top of this meaty stew, filled with easy frozen and canned vegetables.
Next time, use beef stew meat instead of round steak.
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There is disclosed herein a step lighting fixture including an extrusion having a single channel for receiving a light directing member which directs light from a single lighting string both upwardly and downwardly with respect to a stair edge or stair nose. This enables the edge of a stair and the riser thereof or next lower step to be readily seen by one either descending or ascending the stair or stairway. The light directing member can include a pair of reflectors for reflecting light upwardly and downwardly. Alternatively, it can include a single reflector for reflecting light upwardly, and another section, either clear, segmented or both clear and segmented, for directing light downwardly.
1. A step lighting fixture comprising
an extrusion having a channel for receiving a light directing member and lighting string holder, the extrusion having first and second sections substantially at a right angle to each other for mating with a step edge,
a light directing member disposed in the channel of the extrusion and being configured to slide into the channel and be retained therein, the light directing member having a first reflector area for reflecting light upwardly through the extrusion to direct light upwardly from the step lighting fixture capable of being viewed by one walking down a step, and the light directing member further including a second area for enabling light to be directed downwardly toward a riser and/or a step below, and including a holder section for holding and supporting a lighting strip member, and
a lighting strip member including a plurality of light sources disposed in the holder section of the light directing member for thereby providing a fixture for directing light from the lighting strip member both upwardly and downwardly from a single lighting strip member.
2. A step lighting fixture as in claim 1 wherein the extrusion is formed of extruded PVC and with a lens section in the first section thereof through which light reflected from the reflector area of the light directing member can pass through.
3. A step lighting fixture as in claim 2 wherein the lens section is translucent.
4. A step lighting fixture as in claim 1 including a second reflector area for reflecting light to enhance the light directed downwardly toward the step below.
5. A step lighting fixture as in claim 1 wherein the light directing member has a segmented section for directing light downwardly toward a riser below.
6. A step lighting fixture as in claim 5 wherein the segmented area is a prism type section.
7. A step lighting fixture as in claim 1 wherein the light directing member includes a substantially clear section for allowing light from the lighting strip member to impinge downwardly toward the step below.
8. A step lighting fixture as in claim 7 wherein the light directing member also includes a segmented section for directing light toward a riser below.
9. A step lighting fixture as in claim 1 wherein the light directing member has first and second edges for mounting with interior areas of a channel of the extrusion for supporting and securing the light directing member within the extrusion, and wherein the light strip member comprises a plurality of LED's disposed in a spaced apart relationship from one end to the other of the light directing member.
10. A step lighting fixture as in claim 9 wherein the light directing member includes a holder section for receiving and holding the lighting strip member.
11. A step lighting fixture as in claim 10 wherein the light directing member includes a clear lens section for directing light toward a step below and a segmented section for directing light toward a riser below.
12. A method of providing low level illumination at a stair edge via a step lighting fixture having a plurality of light sources extending substantially across the vicinity of a stair edge comprising reflecting light from the light sources upwardly from an upper stair edge, and directing light from the light sources downwardly toward a next lower stair, all with a single string of light sources providing the upwardly and downwardly directed illumination.
13. A method as in claim 12 comprising the step of further reflecting light from the light sources to enhance the downwardly directed illumination.
14. A method as in claim 12 further including refracting light from the light sources downwardly.
15. A method as in claim 12 including transmitting light downwardly toward a step below and refracting light downwardly toward a riser below.
The present invention relates to lighting systems, and more particularly to step lighting for stairway steps for providing light directed upwardly and downwardly from a single lighting system.
Various forms of lighting systems have been devised for lighting aisles, stairs, floors, ceilings, and the like. Typically, low voltage string lighting systems are used which incorporate an incandescent or LED lighting strip having a number of spaced light bulbs or light sources.
In the case of steps and stairs, typically one or more stair "nosing" strips are provided at the edge or "nose" of each stair. For a number of years these devices have been provided for illuminating either upwardly from the forward edge of the stair or downwardly onto the riser and/or the next lower step so that the edge of each stair is illuminated whether one is walking up or down the stairway. Lighting systems of this nature are particularly desirable and useful in environments where the lighting level is low, such as in motion picture theaters and the like. With the advent of "stadium" type seating in motion picture theaters, stairs are more common in these theaters today, thereby creating a further need for suitable stair edge nose lighting.
Various forms of extrusions, either of metal such as aluminum, or plastic have been devised for holding a string of spaced light sources on a stair nose for either illumination upwardly or downwardly, or both. Typical lighting systems of this nature for illuminating both upwardly and downwardly involve either an extrusion for containing two sets of lights, or plural extrusions which are joined together with each holding a set of lights, for providing the upward and downward lighting. Generally, these lighting systems are relatively complicated to because of the dual lighting systems involved.
Accordingly, the present invention provides an improved step lighting system for the stair edge or nose, and wherein a single lighting string provides both the upward and downward illumination. In one embodiment, a combined lens and reflector is provided to allow light from a string of lights to be reflected upwardly and light from that string to impinge through the lens downwardly toward the riser and/or step below. In another embodiment, the extrusion houses a prism-type lens assembly for directing light both upwardly and downwardly. In another embodiment, the extrusion houses a dual reflector system for reflecting light from a light string both upwardly and downwardly. In a still further and preferred embodiment, the extension houses a lens and prism-type lens assembly for directing light both upwardly and downwardly but with improved downward illumination. In each instance, the extrusion may include slots at either end thereof for receiving the ends of carpet, such as carpet on the step and carpet on the riser.
Accordingly, it is an object of the present invention to provide an improved lighting system.
An additional object of the present invention is to provide an improved step nose lighting system.
A further object of the present invention is to provide a single extrusion for a stair nose for holding a light directing member for directing light from a single string of lights both upwardly and downwardly from the vicinity of a stair edge.
These and other objects and features of the present invention will become better understood through a consideration of the following description taken in conjunction with the drawings in which:
FIG. 1 is a perspective view of part of a stairway illustrating exemplary step lighting of the present invention;
FIG. 2 is a cross-section view of a first embodiment of a step lighting system of the present invention;
FIG. 3 illustrates another embodiment thereof using a prism lens assembly;
FIG. 4 illustrates a further embodiment of a light directing member of a step lighting system of the present invention using a dual reflector system;
FIG. 5 illustrates a preferred embodiment of a light directing member of a step lighting system of the present invention using a combined lens and prism lens assembly; and
FIG. 6 shows a cross-section view of a wireway for use with the stair nose extrusions hereof.
Turning now to the drawings, and first to FIG. 1, a portion of a stairway is shown comprising first and second steps 10 and 12 each comprising a respective step top 10a and 12a and riser 10a and 12b. A step nose extrusion 16 is provided for the step 10 and extrusion 18 is provided for the step 12, it being understood that a fewer or greater number of steps than those shown may be involved. These extrusions are, for example, typically thirty inches or so wide and extend substantially from end to end of the step edge. They contain a plurality of spaced, small sources of light. Wireways 20 and 22 on the respective sides of the steps 10 and 12 are illustrated, and these contain the electrical wiring harnesses for supplying power to lights mounted in the nose extrusions 16 and 18. The wireways can be installed on both sides as shown or on only one side of the steps, depending on the wiring requirements of the particular installation, and these typically include an extrusion 20, 22 as shown, along with snap-on cover sections such as 18b and 18c as seen to the upper right in FIG. 1 for step 12. Each of the extrusions has an upper clear or frosted lens section 16a, 18a which will be explained in greater detail in connection with a discussion of FIGS. 2-4.
Each of the extrusions 16 or 18, as will be described in detail below, preferably is a plastic extrusion and includes a light directing member therein for directing light upwardly and downwardly, and includes therein a string of lights, either incandescent, LED or the like extending substantially from end to end of the extrusion. The light directing member can be designed to reflect the light from the string of lights, or to refract the light as by prism elements or sections, or both reflect and transmit the light upwardly and downwardly, or both transmit and refract the light so as to provide suitable illumination for the top edge of the step when someone is walking down the stairs, and further to provide suitable illumination for the riser and/or the top of a step or steps below as one ascends the stairway. Furthermore, the extrusions preferably include slots for receiving carpet edges of carpet on the tops of the steps and on the risers of the steps.
Turning now to FIG. 2, a first embodiment of the present invention is illustrated. This Figure is a cross-section view of a stair nose extrusion as well as of a light directing member, along with a lighting strip. For discussion purposes, the extrusion shown in FIG. 2 is considered to be that of the top step, namely extrusion 18 of FIG. 1. It includes top 18d and riser 18e sections at a substantially right angle or L-shaped cross-section to mate and be secured to the top and front edges of a step (not shown in FIG. 2). It further includes a channel 24 for receiving a light directing member 26 and a lighting strip 28. In this embodiment, light from the strip 28 is reflected by a reflector 30 of the member 26 upwardly, and the strip 28 is positioned to direct light downwardly from the strip 28 through a clear or translucent section 32 of the member 26. The light reflected upwardly passes through the clear or frosted lens 18a of the extrusion 18 thereby emanating from the top of the stair nose, and the light through section 32 impinges downwardly directly toward the top of the next lower step and/or onto the riser 12b. The lighting strip typically has LED's spaced 2-4 inches apart across the width of the extrusion (note the light sources 28a as seen in FIG. 1 which extend across the nose of each of the steps).
Considering the light directing member 26 in greater detail, the same preferably is extruded of clear PVC into the cross-sectional shape as seen in FIG. 2, and extends substantially from one end to the other of extrusion 18. The reflector 30 thereof preferably is provided via silver polyester tape applied directly to the member at 30 so as to reflect light from light sources 28a of the strip 28 upwardly through the lens 18a of the extrusion 18. The extrusion 18 typically is extruded PVC, with the lens 18a being extruded simultaneously therewith of clear or no translucent PVC in a conventional manner.
The light directing member 26 has a forward edge 34 which abuts a rear facing edge 18f of the extrusion 18, and has a rear facing edge 35 that abuts a forward face 18g of the extrusion 18. Each of 34, 35, 18f and 18g preferably can be a flat surface or flat edges as seen in FIG. 2 to facilitate sliding the member 26 into the channel 24 of the extrusion 18. The rear facing edge 35 of member 26 angles or curves rearwardly at 36 thereby forming a hook for causing the member 26 to be retained and secured within the channel 24 by virtue of a corner 18h of the extrusion 18 as well as the surfaces 18f and 18g thereof.
The light directing member 26 further includes a concave or essentially a V-shaped upper section 37 which has fingers or ears 38 and 39 for engaging and holding light sources 28a of the strip 28. These light sources 28a are conventional, and typically comprise LED's as noted earlier, and which are connected together by suitable electrical conductors which, in turn, are connected to a low voltage power supply (not shown) for supplying current to the light sources. With the configuration of the upper section 37 of the member 26, it is relatively easy to slide the light sources 28 into the section 37 during manufacture such that members 26 of an appropriate length (e.g., of a length to fit into the extrusions 16 and 18 as seen in FIG. 1) can be provided. Similarly, the extrusions 16 and 18 can be cut to the appropriate lengths at the factory so that when the extrusions and the light directing members are delivered to the job site, they are already cut to the appropriate lengths to thereby simplify assembly onto the edge or nose or the stairs with screws, adhesives, or any other suitable fastening means conventionally used.
The extrusion 18 also includes an upper slot 42 for receiving the end of carpet on top of the step, and a lower slot 44 for receiving the end of carpet or other decorative material provided on the riser below.
Another embodiment is illustrated in FIG. 3 wherein a light directing member 60 uses a reflective surface 62 (similar to 30 of FIG. 2) for reflecting light upwardly from the lighting string 28, and a Fresnel or prism type lens section 64 for refracting and directing the light downwardly. The structure and shape of the member 60 is otherwise the same as member 26. The extrusion 18 and lighting string 28 are the same as those of FIG. 2, except the extrusion at the carpet slot 44a does not have a rear vertical leg as in FIG. 2 and thus an end of the carpet is held between the extrusion 18 at 44a and the face of the step. The section 18e of the extrusion 18 thus does not extend out as far (as that of FIG. 2) and accordingly blocks less light aimed at the riser and step below.
As in the case of FIG. 2, light directing member 60 preferably is extruded from clear polycarbonate to provide both the lens and a holder for the lighting string 28. A silver polyester or other reflective tape can also be provided at 60. This light directing member 60 includes a plurality of segments on each side, such as 64a and 64b, to provide the degree of illumination desired for the downwardly directed light to the riser and step below. The remainder of the member 60 is like member 26 in FIG. 2, the difference being in sections 32 in FIG. 2 and 60 in FIG. 3, and each is extruded preferably of clear PVC.
The third embodiment of a light directing member 80 is shown in FIG. 4 and is like that of FIG. 2 but uses an additional reflector. It is used with the same type nose extrusion 18 (not shown in FIG. 4). A first reflector 82 (like 30 of FIG. 2 and 62 of FIG. 3) is used and an additional reflector 84, along with a clear lens section 86 for the light directing member 80. The extrusion for the member 80 is the same as in FIG. 2 with the exception of the added reflector 84, and the lighting string 28 is the same. The reflectors 84 and 82 are provided by silver polyester tape as in the previous embodiments.
FIG. 5 illustrates a preferred embodiment of a light directing member 90, and which is similar to that of FIGS. 2 and 3 and combines the best features of both. It has been found that in some applications the prism 64 arrangement of FIG. 3 may not provide as much light as is desired on the step below. In the embodiment of FIG. 5 the overall lens section 92 has both a clear lens section 94 and a prism-type lens section 96. By eliminating the upper prism section and providing a clear lens section 94, more light is directed downwardly toward the step below, whereas the prism section 96 directs light toward the riser. It is believed that this configuration provides a better balance of light onto the riser and the step below in some applications than the full prism 64 arrangement of FIG. 3 which provides more light on the riser and less on the step below than the arrangement of FIG. 5. The light directing member 90 of FIG. 5 includes a reflector 98 similar to the reflectors 30, 62 and 82 of FIGS. 2-4, and the structure and shape of the member 90 is otherwise the same as member 26.
Finally, FIG. 6 illustrates a cross-sectional view of a typical wireway extrusion 100 used with the stair nose extrusions 16, 18 to provide a channel for wires connecting the lighting strips for each of the extrusions to a suitable source of electrical power. This extrusion 100 includes an interior channel 102 for receiving the connecting wires (not shown), and which is covered by a cover 104 similar to 18b and 18c of FIG. 1. The cover 104 snaps in at 105, 106 as seen in FIG. 6 to provide a suitable cover over the electrical conductors.
While embodiments of the present invention have been shown and described, various modifications may be made without departing from the scope of the present invention, and all such modifications and equivalents are intended to be covered.
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