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Publications (58)181.55 Total impact
Article: Fat gain with physical detraining is correlated with increased glucose transport and oxidation in periepididymal white adipose tissue in rats[Show abstract] [Hide abstract]
ABSTRACT: As it is a common observation that obesity tends to occur after discontinuation of exercise, we investigated how white adipocytes isolated from the periepididymal fat of animals with interrupted physical training transport and oxidize glucose, and whether these adaptations support the weight regain seen after 4 weeks of physical detraining. Male Wistar rats (45 days old, weighing 200 g) were divided into two groups (n=10): group D (detrained), trained for 8 weeks and detrained for 4 weeks; and group S (sedentary). The physical exercise was carried out on a treadmill for 60 min/day, 5 days/week for 8 weeks, at 50-60% of the maximum running capacity. After the training protocol, adipocytes isolated from the periepididymal adipose tissue were submitted to glucose uptake and oxidation tests. Adipocytes from detrained animals increased their glucose uptake capacity by 18.5% compared with those from sedentary animals (P<0.05). The same cells also showed a greater glucose oxidation capacity in response to insulin stimulation (34.55%) compared with those from the S group (P<0.05). We hypothesize that, owing to the more intense glucose entrance into adipose cells from detrained rats, more substrate became available for triacylglycerol synthesis. Furthermore, this increased glucose oxidation rate allowed an increase in energy supply for triacylglycerol synthesis. Thus, physical detraining might play a role as a possible obesogenic factor for increasing glucose uptake and oxidation by adipocytes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 05/2015; DOI:10.1590/1414-431X20154356 · 1.08 Impact Factor
Article: Pioglitazone Treatment Increases Survival and Prevents Body Weight Loss in Tumor– Bearing Animals: Possible Anti-Cachectic Effect[Show abstract] [Hide abstract]
ABSTRACT: Cachexia is a multifactorial syndrome characterized by profound involuntary weight loss, fat depletion, skeletal muscle wasting, and asthenia; all symptoms are not entirely attributable to inadequate nutritional intake. Adipose tissue and skeletal muscle loss during cancer cachexia development has been described systematically. The former was proposed to precede and be more rapid than the latter, which presents a means for the early detection of cachexia in cancer patients. Recently, pioglitazone (PGZ) was proposed to exhibit anti-cancer properties, including a reduction in insulin resistance and adipose tissue loss; nevertheless , few studies have evaluated its effect on survival. For greater insight into a potential anti-cachectic effect due to PGZ, 8-week-old male Wistar rats were subcutaneously inocu-lated with 1 mL (2×10 7) of Walker 256 tumor cells. The animals were randomly assigned toPLoS ONE 03/2015; 10(3):1-16. DOI:10.1371/journal.pone.0122660 · 3.53 Impact Factor
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ABSTRACT: Melatonin, the main hormone produced by the pineal gland, is secreted in a circadian manner (24-h period) and its oscillation influences several circadian biological rhythms, such as the regulation of clock genes expression (chronobiotic effect) and the modulation of several endocrine functions in peripheral tissues. Assuming that the circadian synchronization of clock genes can play a role in the regulation of energy metabolism and it is influenced by melatonin, our study was designed to assess possible alterations as a consequence of melatonin absence on the circadian expression of clock genes in the epididymal adipose tissue of male Wistar rats, and the possible metabolic repercussions to this tissue. Our data show that pinealectomy indeed has impacts on molecular events: it abolishes the daily pattern of the expression of Clock, Per2 and Cry1 clock genes and Pparγ expression, significantly increases the amplitude of daily expression of Rev-erbα, affects the pattern of and impairs adipokine production, leading to a decrease in leptin levels. However, regarding some metabolic aspects of adipocyte functions, such as its ability to synthesize triacylglycerols from glucose along 24 hour, was not compromised by pinealectomy, although the daily profile of the lipogenic enzymes expression (ATP-citrate lyase, malic enzyme, fatty acid synthase and glucose-6-phosphate dehydrogenase) was abolished in pinealectomized animals. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Journal of Pineal Research 01/2015; 58(3). DOI:10.1111/jpi.12211 · 7.81 Impact Factor
Article: Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation[Show abstract] [Hide abstract]
ABSTRACT: Palmitoleic acid was previously shown to improve glucose homeostasis by reducing hepatic glucose production and by enhancing insulin-stimulated glucose uptake in skeletal muscle. Herein we tested the hypothesis that palmitoleic acid positively modulates glucose uptake and metabolism in adipocytes. For this, both differentiated 3 T3-L1 cells treated with either palmitoleic acid (16:1n7, 200 muM) or palmitic acid (16:0, 200 muM) for 24 h and primary adipocytes from mice treated with 16:1n7 (300 mg/kg/day) or oleic acid (18:1n9, 300 mg/kg/day) by gavage for 10 days were evaluated for glucose uptake, oxidation, conversion to lactate and incorporation into fatty acids and glycerol components of TAG along with the activity and expression of lipogenic enzymes. Treatment of adipocytes with palmitoleic, but not oleic (in vivo) or palmitic (in vitro) acids, increased basal and insulin-stimulated glucose uptake and GLUT4 mRNA levels and protein content. Along with uptake, palmitoleic acid enhanced glucose oxidation (aerobic glycolysis), conversion to lactate (anaerobic glycolysis) and incorporation into glycerol-TAG, but reduced de novo fatty acid synthesis from glucose and acetate and the activity of lipogenic enzymes glucose 6-phosphate dehydrogenase and ATP-citrate lyase. Importantly, palmitoleic acid induction of adipocyte glucose uptake and metabolism were associated with AMPK activation as evidenced by the increased protein content of phospho(p)Thr172AMPKalpha, but no changes in pSer473Akt and pThr308Akt. Importantly, such increase in GLUT4 content induced by 16:1n7, was prevented by pharmacological inhibition of AMPK with compound C. In conclusion, palmitoleic acid increases glucose uptake and the GLUT4 content in association with AMPK activation.Lipids in Health and Disease 12/2014; 13(1):199. DOI:10.1186/1476-511X-13-199 · 2.31 Impact Factor
Article: l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation.[Show abstract] [Hide abstract]
ABSTRACT: Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.Nutrients 04/2014; 6(4):1364-73. DOI:10.3390/nu6041364 · 3.15 Impact Factor
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ABSTRACT: Numerous studies address the physiology of adipose tissue (AT). The interest surrounding the physiology of AT is primarily the result of the epidemic outburst of obesity in various contemporary societies. Briefly, the two primary metabolic activities of white AT include lipogenesis and lipolysis. Throughout the last two decades, a new model of AT physiology has emerged. Although AT was considered to be primarily an abundant energy source, it is currently considered to be a prolific producer of biologically active substances, and, consequently, is now recognized as an endocrine organ. In addition to leptin, other biologically active substances secreted by AT, generally classified as cytokines, include adiponectin, interleukin-6, tumor necrosis factor-alpha, resistin, vaspin, visfatin, and many others now collectively referred to as adipokines. The secretion of such biologically active substances by AT indicates its importance as a metabolic regulator. Cell turnover of AT has also recently been investigated in terms of its biological role in adipogenesis. Consequently, the objective of this review is to provide a comprehensive critical review of the current literature concerning the metabolic (lipolysis, lipogenesis) and endocrine actions of AT.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 03/2014; 47(3):192-205. DOI:10.1590/1414-431X20132911 · 1.08 Impact Factor
- Arquivos brasileiros de endocrinologia e metabologia 02/2014; 58(1):81-2. · 0.68 Impact Factor
Article: Chronic glucocorticoid treatment enhances lipogenic activity in visceral adipocytes of male Wistar rats.[Show abstract] [Hide abstract]
ABSTRACT: Glucocorticoid (GC) in excess promotes the redistribution of adipose tissue from peripheral to central sites of the body. In this study we characterized an experimental condition of prolonged GC excess and investigated its effect on the lipogenic metabolism in white adipose tissue. Twenty male Wistar rats were divided into control (CON) and dexamethasone treated (DEX) groups. DEX group received dexamethasone (0.25 mg/kg/day) during 4 weeks, while CON group received saline. Animals were sacrificed and subcutaneous (SC), retroperitoneal (RP) and mesenteric (MS) fat pads were excised, weighed and processed for adipocyte isolation, morphometric cell analysis and incorporation of glucose into lipids. The treatment effectively blocked hypothalamic-pituitary-adrenal axis, as verified by a 58% decrease in plasma corticosterone levels and 19% atrophy in adrenal glands in DEX group. Animals from DEX group presented insulin resistance, glucose intolerance, dyslipidemia and increased insulin and leptin plasma levels and hypertrophied adipocytes. They showed increased lipogenesis in RP and MS depots, with increased incorporation of glucose into fatty acids of triacylglycerol. Increased activity of lipogenic enzymes ATP-citrate liase, fatty acid synthase, glucose-6-phosphate dehydrogenase and malic were only seen in the MS depot in DEX group, while gene expression of these enzymes was enhanced in SC and MS fat depots. The adaptations promoted by GC treatment in adipose metabolism seemed to be mainly due to the increased activity of enzymes that supply the NADPH required for lipogenesis than to the increase in enzymes that more directly deal with fatty acid synthesis itself. This article is protected by copyright. All rights reserved.Acta Physiologica 01/2014; DOI:10.1111/apha.12226 · 4.25 Impact Factor
- Arquivos Brasileiros de Endocrinologia & Metabologia 01/2014; 58(1):81-82. DOI:10.1590/0004-2730000002727 · 0.68 Impact Factor
- AJP Endocrinology and Metabolism 12/2013; 305(12):E1521. DOI:10.1152/ajpendo.00580.2013 · 4.09 Impact Factor
Article: Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipases content in a PPARα dependent manner.[Show abstract] [Hide abstract]
ABSTRACT: Here we investigated whether palmitoleic acid, a fatty acid that enhances whole body glucose disposal and suppresses hepatic steatosis, modulates triacylglycerol (TAG) metabolism in adipocytes. For this, both differentiated 3T3-L1 cells treated with either palmitoleic acid (16:1n7, 200 µM) or palmitic acid (16:0, 200 µM) for 24h and primary adipocytes from wild type or PPARα deficient mice treated with 16:1n7 (300 mg/kg/day) or oleic acid (18:1n9, 300 mg/kg/day) by gavage for 10 days were evaluated for lipolysis, TAG and glycerol 3-phosphate synthesis and gene and protein expression profile. Treatment of differentiated 3T3-L1 cells with 16:1n7, but not 16:0, increased basal and isoproterenol-stimulated lipolysis, mRNA levels of adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL) and protein content of ATGL and pSer660-HSL. Such increase in lipolysis induced by 16:1n7, which can be prevented by pharmacological inhibition of PPARα, was associated with higher rates of PPARα binding to DNA. In contrast to lipolysis, both 16:1n7 and 16:0 increased fatty acid incorporation into TAG and glycerol 3-phosphate synthesis from glucose, without affecting glyceroneogenesis and glycerokinase expression. Corroborating in vitro findings, treatment of wild type, but not PPARα deficient mice with 16:1n7 increased primary adipocytes basal and stimulated lipolysis and ATGL and HSL mRNA levels. In contrast to lipolysis, however, 16:1n7 treatment increased fatty acid incorporation into TAG and glycerol 3-phosphate synthesis from glucose in both wild type and PPARα deficient mice. In conclusion, palmitoleic acid increases adipocyte lipolysis and lipases by a mechanism that requires a functional PPARα.AJP Endocrinology and Metabolism 09/2013; 305(9). DOI:10.1152/ajpendo.00082.2013 · 4.09 Impact Factor
Article: Cessation of physical exercise changes metabolism and modifies the adipocyte cellularity of the periepididymal white adipose tissue in rats[Show abstract] [Hide abstract]
ABSTRACT: The adaptations to physical training are reversible with inactivity. Although significant reductions in maximal oxygen uptake (VO2Max) are observed following detraining, its consequences to the adipose tissue are poorly known. Our aim was therefore to investigate effects of discontinuing training (detraining) on the metabolism and adipocyte cellularity of rat periepididymal (PE) adipose tissue. Male Wistar rats, aged 6 weeks, were divided into 3 groups (studied for 12 weeks) under the following conditions: (1) trained (T) throughout the period; (2) detrained (D), trained (first 8 weeks) and detrained (last 4 weeks); and (3) age-matched sedentary (S). Training consisted of treadmill running sessions (1 h/day, 5 d/week, 50-60% VO2Max). The PE adipocyte size enlarged. The cross-sectional area (in µm(2)) was larger in D than in the T and S groups (3474 ± 68.8; 1945.7 ± 45.6; 2492.4 ± 49.08, respectively, p<0.05). Compared with T, the isolated adipose cells (D rats) showed a 48% increase in both basal and maximally insulin-stimulated lipogenesis and in isoproterenol-stimulated lipolysis. A 15% reduction in apoptotic adipocytes was observed in groups T and D compared to S. The levels of adiponectin (3x) and PPAR-gamma (2x) gene expression were up-regulated in D vs. S. PREF-1 gene expression was 3-fold higher in T vs. S. From these results, we hypothesize that adipogenesis was stimulated in group D and accompanied by significant hypertrophy and increased lipogenic capacity of the adipocytes. And with the reduced fat cell apoptosis in D and T rats, it raises the possibility that these changes are obesogenic.Journal of Applied Physiology 05/2013; 115(3). DOI:10.1152/japplphysiol.01272.2012 · 3.43 Impact Factor
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ABSTRACT: Background Kinins participate in the pathophysiology of obesity and type 2 diabetes by mechanisms which are not fully understood. Kinin B1 receptor knockout mice (B1−/−) are leaner and exhibit improved insulin sensitivity. Methodology/Principal Findings Here we show that kinin B1 receptors in adipocytes play a role in controlling whole body insulin action and glucose homeostasis. Adipocytes isolated from mouse white adipose tissue (WAT) constitutively express kinin B1 receptors. In these cells, treatment with the B1 receptor agonist des-Arg9-bradykinin improved insulin signaling, GLUT4 translocation, and glucose uptake. Adipocytes from B1−/− mice showed reduced GLUT4 expression and impaired glucose uptake at both basal and insulin-stimulated states. To investigate the consequences of these phenomena to whole body metabolism, we generated mice where the expression of the kinin B1 receptor was limited to cells of the adipose tissue (aP2-B1/B1−/−). Similarly to B1−/− mice, aP2-B1/B1−/− mice were leaner than wild type controls. However, exclusive expression of the kinin B1 receptor in adipose tissue completely rescued the improved systemic insulin sensitivity phenotype of B1−/− mice. Adipose tissue gene expression analysis also revealed that genes involved in insulin signaling were significantly affected by the presence of the kinin B1 receptor in adipose tissue. In agreement, GLUT4 expression and glucose uptake were increased in fat tissue of aP2-B1/B1−/− when compared to B1−/− mice. When subjected to high fat diet, aP2-B1/B1−/− mice gained more weight than B1−/− littermates, becoming as obese as the wild types. Conclusions/Significance Thus, kinin B1 receptor participates in the modulation of insulin action in adipocytes, contributing to systemic insulin sensitivity and predisposition to obesity.PLoS ONE 09/2012; 7(9). DOI:10.1371/journal.pone.0044782 · 3.53 Impact Factor
Article: Identification of intracellular peptides in rat adipose tissue: Insights into insulin resistance[Show abstract] [Hide abstract]
ABSTRACT: Intracellular peptides generated by the proteasome and oligopeptidases have been suggested to function in signal transduction and to improve insulin resistance in mice fed a high-caloric diet. The aim of this study was to identify specific intracellular peptides in the adipose tissue of Wistar rats that could be associated with the physiological and therapeutic control of glucose uptake. Using semiquantitative mass spectrometry and LC/MS/MS analyses, we identified ten peptides in the epididymal adipose tissue of the Wistar rats; three of these peptides were present at increased levels in rats that were fed a high-caloric Western diet (WD) compared with rats fed a control diet (CD). The results of affinity chromatography suggested that in the cytoplasm of epididymal adipose tissue from either WD or CD rats, distinctive proteins bind to these peptides. However, despite the observed increase in the WD animals, the evaluated peptides increased insulin-stimulated glucose uptake in 3T3-L1 adipocytes treated with palmitate. Thus, intracellular peptides from the adipose tissue of Wistar rats can bind to specific proteins and facilitate insulin-induced glucose uptake in 3T3-L1 adipocytes.Proteomics 08/2012; 12(17):2668-81. DOI:10.1002/pmic.201200051 · 3.97 Impact Factor
Article: Metabolic Disorders and Adipose Tissue Insulin Responsiveness in Neonatally STZ-Induced Diabetic Rats Are Improved by Long-Term Melatonin Treatment[Show abstract] [Hide abstract]
ABSTRACT: Diabetes mellitus is a product of low insulin sensibility and pancreatic β-cell insufficiency. Rats with streptozotocin-induced diabetes during the neonatal period by the fifth day of age develop the classic diabetic picture of hyperglycemia, hypoinsulinemia, polyuria, and polydipsia aggravated by insulin resistance in adulthood. In this study, we investigated whether the effect of long-term treatment with melatonin can improve insulin resistance and other metabolic disorders in these animals. At the fourth week of age, diabetic animals started an 8-wk treatment with melatonin (1 mg/kg body weight) in the drinking water at night. Animals were then killing, and the sc, epididymal (EP), and retroperitoneal (RP) fat pads were excised, weighed, and processed for adipocyte isolation for morphometric analysis as well as for measuring glucose uptake, oxidation, and incorporation of glucose into lipids. Blood samples were collected for biochemical assays. Melatonin treatment reduced hyperglycemia, polydipsia, and polyphagia as well as improved insulin resistance as demonstrated by constant glucose disappearance rate and homeostasis model of assessment-insulin resistance. However, melatonin treatment was unable to recover body weight deficiency, fat mass, and adipocyte size of diabetic animals. Adiponectin and fructosamine levels were completely recovered by melatonin, whereas neither plasma insulin level nor insulin secretion capacity was improved in diabetic animals. Furthermore, melatonin caused a marked delay in the sexual development, leaving genital structures smaller than those of nontreated diabetic animals. Melatonin treatment improved the responsiveness of adipocytes to insulin in diabetic animals measured by tests of glucose uptake (sc, EP, and RP), glucose oxidation, and incorporation of glucose into lipids (EP and RP), an effect that seems partially related to an increased expression of insulin receptor substrate 1, acetyl-coenzyme A carboxylase and fatty acid synthase. In conclusion, melatonin treatment was capable of ameliorating the metabolic abnormalities in this particular diabetes model, including insulin resistance and promoting a better long-term glycemic control.Endocrinology 02/2012; 153(5):2178-88. DOI:10.1210/en.2011-1675 · 4.64 Impact Factor
Article: Effects of antipsychotics with different weight gain liabilities on human in vitro models of adipose tissue differentiation and metabolism[Show abstract] [Hide abstract]
ABSTRACT: Weight gain and metabolic abnormalities are serious side effects associated with the use of several second generation antipsychotics (SGA). The adipose tissue has been considered a direct SGA target involved in the development of these adverse effects. Recent studies, mainly using murine cells, have suggested that SGA increase both adipogenesis of preadipocytes and lipid accumulation in mature adipocytes. However, to date there has been little research comparing the effects of antipsychotics with different propensities to induce weight gain on human in vitro models of white adipose tissue neoformation and metabolism. The present study aimed to investigate the effects of antipsychotics either strongly associated with weight gain, such as the SGA clozapine and olanzapine, or not, such as the SGA ziprasidone and the classical antipsychotic haloperidol, on proliferation and adipocyte differentiation of human adipose-derived stem cells (ADSCs) and lipogenesis in human mature adipocytes. Whereas ziprasidone induced elevated levels of cell death during adipogenesis and could not be investigated further, we observed that clozapine, olanzapine and haloperidol had slight stimulatory effects on the transcriptional program of ADSCs adipogenesis. However, the observed changes in adipocyte-specific genes were not accompanied by a significant increase in triglyceride accumulation within differentiated adipocytes. Our data also showed that these three antipsychotics displayed inhibitory effects on the proliferation rates of undifferentiated ADSCs. Regarding mature adipocyte metabolism, we observed that olanzapine slightly inhibited insulin-stimulated lipogenesis at the highest concentration used, and haloperidol exerted the strongest inhibitory effects on both basal and insulin-stimulated lipogenesis. Taken together, our results suggest that a direct and potent effect of clozapine and olanzapine on adipose tissue biology is not an important mechanism by which these SGA induce metabolic disturbances in humans. On the other hand, the haloperidol-mediated downregulation of the lipogenic capacity of human adipose tissue may be a possible mechanism contributing to its lower propensity to induce serious metabolic side effects.Progress in Neuro-Psychopharmacology and Biological Psychiatry 08/2011; 35(8):1884-90. DOI:10.1016/j.pnpbp.2011.07.017 · 4.03 Impact Factor
Article: Exercise Training and Caloric Restriction Prevent Reduction in Cardiac Ca2+-Handling Protein Profile in Obese Rats[Show abstract] [Hide abstract]
ABSTRACT: Previous studies show that exercise training and caloric restriction improve cardiac function in obesity. However, the molecular mechanisms underlying this effect on cardiac function remain unknown. Thus, we studied the effect of exercise training and/or caloric restriction on cardiac function and Ca(2+) handling protein expression in obese rats. To accomplish this goal, male rats fed with a high-fat and sucrose diet for 25 weeks were randomly assigned into 4 groups: high-fat and sucrose diet, high-fat and sucrose diet and exercise training, caloric restriction, and exercise training and caloric restriction. An additional lean group was studied. The study was conducted for 10 weeks. Cardiac function was evaluated by echocardiography and Ca(2+) handling protein expression by Western blotting. Our results showed that visceral fat mass, circulating leptin, epinephrine, and norepinephrine levels were higher in rats on the high-fat and sucrose diet compared with the lean rats. Cardiac nitrate levels, reduced/oxidized glutathione, left ventricular fractional shortening, and protein expression of phosphorylated Ser(2808)-ryanodine receptor and Thr(17)-phospholamban were lower in rats on the high-fat and sucrose diet compared with lean rats. Exercise training and/or caloric restriction prevented increases in visceral fat mass, circulating leptin, epinephrine, and norepinephrine levels and prevented reduction in cardiac nitrate levels and reduced:oxidized glutathione ratio. Exercise training and/or caloric restriction prevented reduction in left ventricular fractional shortening and in phosphorylation of the Ser(2808)-ryanodine receptor and Thr(17)-phospholamban. These findings show that exercise training and/or caloric restriction prevent cardiac dysfunction in high-fat and sucrose diet rats, which seems to be attributed to decreased circulating neurohormone levels. In addition, this nonpharmacological paradigm prevents a reduction in the Ser(2808)-ryanodine receptor and Thr(17)-phospholamban phosphorylation and redox status.Hypertension 10/2010; 56(4):629-35. DOI:10.1161/HYPERTENSIONAHA.110.156141 · 7.63 Impact Factor
Article: Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPβ transcriptional activity[Show abstract] [Hide abstract]
ABSTRACT: Considering that melatonin has been implicated in body weight control, this work investigated whether this effect involves the regulation of adipogenesis. 3T3-L1 preadipocytes were induced to differentiate in the absence or presence of melatonin (10(-3) m). Swiss-3T3 cells ectopically and conditionally (Tet-off system) over-expressing the 34 kDa C/EBPbeta isoform (Swiss-LAP cells) were employed as a tool to assess the mechanisms of action at the molecular level. Protein markers of the adipogenic phenotype were analyzed by Western blot. At 36 hr of differentiation of 3T3-L1 preadipocytes, a reduction of PPARgamma expression was detected followed by a further reduction, at day 4, of perilipin, aP2 and adiponectin protein expression in melatonin-treated cells. Real-time PCR analysis also showed a decrease of PPARgamma (60%), C/EBPalpha (75%), adiponectin (30%) and aP2 (40%) mRNA expression. Finally, we transfected Swiss LAP cells with a C/EBPalpha gene promoter/reporter construct in which luciferase expression is enhanced in response to C/EBPbeta activity. Culture of such transfected cells in the absence of tetracycline led to a 2.5-fold activation of the C/EBPalpha promoter. However, when treated with melatonin, the level of C/EBPalpha promoter activation by C/EBPbeta was reduced by 50% (P = 0.05, n = 6). In addition, this inhibitory effect of melatonin was also reflected in the phenotype of the cells, since their capacity to accumulate lipids droplets was reduced as confirmed by the poor staining with Oil Red O. In conclusion, melatonin at a concentration of 10(-3 ) m works as a negative regulator of adipogenesis acting in part by inhibiting the activity of a critical adipogenic transcription factor, C/EBPbeta.Journal of Pineal Research 09/2009; 47(3):221-7. DOI:10.1111/j.1600-079X.2009.00705.x · 7.81 Impact Factor
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ABSTRACT: Obesity is one of the major Public Health problems. Obese individuals are more susceptible to develop cardiovascular diseases and type 2 diabetes mellitus. The obesity results from the increase in size and number of the adipocytes. The balance between adipogenesis and adiposity determines the degree of obesity. Mature adipocytes secrete adipokines, such as TNFalpha, IL-6, leptine and adiponectin, and lipokine, the palmitoleic acid omega-7. The production of adipokines is increased in obesity, contributing to the onset of peripheral insulin resistance. The knowledge about the molecular events that regulate the differentiation of pre-adipocytes and mesenchymal stem cells into adipocytes (adipogenesis) is important for the comprehension of the genesis of obesity. Activation of transcription factor PPARgamma plays an essential role in the adipogenesis. Certain fatty acids are PPARgamma ligands and can control adipogenesis. Moreover, some fatty acids act as signaling molecules regulating their differentiation into adipocytes or death. Accordingly, the lipid composition of the diet and PPARgamma agonists can regulate the balance between adipogenesis and death of adipocytes and, therefore, the obesity.Arquivos brasileiros de endocrinologia e metabologia 07/2009; 53(5):582-94. · 0.68 Impact Factor
Article: Effect Of Leucine And Exercise On Fat And Metabolism Of Glucose In Previously Obese Rats: 2316Medicine & Science in Sports & Exercise 01/2009; 41. DOI:10.1249/01.MSS.0000355481.46162.ae · 4.46 Impact Factor
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University of São Paulo
San Paulo, São Paulo, Brazil
- Department of Physiology and Biophysics (ICB)
São Paulo State University
San Paulo, São Paulo, Brazil
- Department of Physics and Biophysics


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Where's the innovation?March 06,2014Windham County will receive from Entergy $10 million facilitating economic development replacing Vermont Yankee in Vernon and neighboring towns, which are being asked at town meeting to raise and appropriate their property taxes to support Southeastern Vermont Economic Development Strategies (SeVEDS).
Self-appointed SeVEDS recently quietly completed its Comprehensive Economic Development Strategy (CEDS) and submitted it to the U.S. Economic Development Administration (EDA). "Once accepted by the EDA, the CEDS will serve as a blueprint for economic development activity in the Windham region" (seveds.com).
The best jobs are created and sustained by proven innovative employers whose skilled employees add unique value to materials, then sell the competitive result for significantly more than it cost: the foundation of Windham County's prosperity and where the $10 million should be spent.
There are many proven innovative employers in Windham County, just three of which are represented on the 18-member SeVEDS board of directors: Chroma Technology (optical filters, employee-owned); Grafton Village Cheese (Windham Foundation); and New Chapter (nutritional supplements, Procter & Gamble, Cincinnati).
Local businesses are represented, not by the Brattleboro Area Chamber of Commerce, but by the Mount Snow Valley Chamber of Commerce, in another world than Vernon and neighboring towns.
Seven board members represent government, supported by taxpayers: Towns of Brattleboro (two), Putney and Rockingham; Brattleboro Development Credit Corporation; Windham Regional Commission and Bennington County Regional Commission ("southeastern" Vermont?).
Seven board members represent conventional service businesses and organizations supported by clients, shoppers, sponsors or tourists: Bartleby's Books (Wilmington); Brattleboro Retreat (mental health and addiction treatment); Richards Group (insurance and financial services); Stevens and Associates (architecture and engineering); Stratton Mountain Ski Resort (Intrawest Resorts Holdings, Denver); Strolling of the Heifers (event promoter, Brattleboro); and Vermont Geeks (two computer consultants, Wilmington).
Why are just three of Windham County's proven innovative employers represented on a board of directors planning to spend $10 million to facilitate economic development replacing Vermont Yankee with equivalent jobs?
Is the current 18-member SeVEDS board of directors, dominated by 14 members representing government and conventional service businesses and organizations, qualified to do this?
VernonMORE IN LettersThe rain in (and) drain falls mainly in the Champlain. Full StoryThank you for your excellent historical perspectives on Vermonts unique contribution to the... Full StoryOn behalf of the hundreds of families who will benefit, bravo to everyone who helped make Pack... Full Story
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- RICHARD'S POOR ALMANACK: On this day 1739, 'Richard Palmer' identified in prison at York Castle as the notorious outlaw DICK TURPIN; IN 1836, Battle of the Alamo begins near San Antonio de Bexar, Texas; 1896, the Tootsie Roll invented by LEO HIRSCHFELD.
- RICHARD'S POOR ALMANACK: On this day in 1472, Orkney, Shetland islands put up as collateral by Norway to Scotland in lieu of dowry for MARGARET OF DENMARK on her marriage with JAMES III, king of Scotland; 1962, JOHN GLENN first American to orbit Earth.
- TOMORROW'S HEADLINES TODAY: City mayoral candidates debate campaign issues; Hartford, Conn., woman still missing; Neal Goswami reports attempts to legislate suicide; local woman loses 100 pounds through TOPS program.
- RICHARD'S POOR ALMANACK: On this day in 1878, JOHN TUNSTALL murdered near Lincoln, New Mexico, by the outlaw JESSE EVANS; in 1930, ELM FARM OLLIE first cow to fly in aircraft, first to be milked airborne; 1955, nuke test WASP; '79, snow in Sahara.
- TOMORROW'S HEADLINES TODAY: Rutland Herald News Editor Alan J. Keays and staff writer Gordon Dritschilo discuss stories planned for the February 18, 2015, edition of the newspaper: Winter budgets maxed, legal marijuana, Springfield bank job, USPS slowdown
- RICHARD'S POOR ALMANACK: On this day in 1249 AD, ANDRE of LONGJUMEAU is dispatched by LOUIS IX of France to meet the KHAGAN, ruler of the Mongol Empire; in 1804, during 1st Barbary War, STEPHEN DECATUR scuttles the pirate-held USS Philadelphia in Tripoli.

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The marshmallow was formed by 2 guitarist/vocalist:Dex & Collin In the year 2010.They journey in music start at year of 1994 when there play at several underground gigs around kk,Sabah.( 1st generation of punk/grunge/alternative scene band in Kota Kinabalu)Dex is the ex-member of Unexplained & Collin is ex member of Frankensteins.In the year 1998, Dex with Collin formed a band called De javu with 2 other band members Jacob(Bass) and the late of Wai-Ex -Molly lip's(Drums-R.I.P.).De javu have performed in few clubs around KK,Sabah from 1999 - 2000 before the band split up.On year 2011, Collin a co-founder of the band is quitting and replace by Zamlee(Ex-Fairytales)and Athosh on Bass(Goth-Doom) The marshmallow music is influenced by The Beatles,The Doors, The Who,Cream,Pink Floyd,Led Zeppelin,Jimi Hendrix,Rolling Stones & others 60's& 70's Classic rock band.


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Tag: diversity
Jun 29, 2015
Long-term Survey to Follow College Students' Experiences With Faith, Diversity
An NC State education professor is helping lead a national, four-year study of college students' interfaith experiences at 130 campuses.
May 21, 2015
Race, Politics, and Neighborhood Schools: What You Can Learn From a School Board Election
Local school board elections can be sleepy affairs, but the past decade saw heated debate over elections to the Wake County Board of Education in North Carolina – a debate that raised issues of race, social ties, and what K-12 schools should do in order to best serve their students.
Apr 20, 2015
What Science Looks Like at NC State
At NC State, science is more than labs, computers and experiments. Science is a story. Science is a calling. Science is diverse. These are the stories of the dual identities of our scientists – the researcher and the everyday man or woman.
Jan 15, 2015
5 Questions on Langston Hughes – MLK Link
English professor Jason Miller takes on five questions about his new book, Origins of the Dream, which makes a tangible link between the poetry of Langston Hughes and the prose of Martin Luther King Jr.
Jan 7, 2015
Woodson Urges Tolerance, Respect
Chancellor Randy Woodson kicks off the new semester by urging the campus community to embrace our shared values of empathy, respect, tolerance and equality.
Jan 7, 2015
Higher Ed Leader Rosalind Fuse-Hall to Speak at NC State
Rosalind Fuse-Hall, president of Bennett College, will be giving the College of Humanities and Social Sciences Martin Luther King Lecture on "The Strength of Diversity."
Nov 24, 2014
First-Year Class Boasts Highest Percentage of Female Engineers
NC State's 2014 first-year engineering class includes the highest percentage of female students in university history. A change in focus and a series of programs help draw those students and support their studies.
Nov 4, 2014
Intersectionality: The Importance of Acknowledging Diverse Experiences to Make STEM More Inclusive
Fay Cobb Payton recently published a book on what can be done to make STEM more inclusive. We sat down to talk with Payton about the book, her work, and why STEM diversity matters for both the research community and the corporate world.
Oct 8, 2014
Report Outlines Efforts to Boost Diversity in Materials Science and Engineering Community
NC State played a leadership role in crafting a new national report addressing the lack of diversity in materials science and engineering.
Sep 18, 2014
NC State Leads in Promoting Diversity
The nation's largest higher-ed diversity magazine has honored NC State for its commitment to diversity and inclusion.


text:
Early detection can even help reverse dementia, say PGI doctors
Top Stories
- PM Modi should resign if he can't ask four ministers to step down: Congress
- Lalit Modi names 2 Indian, 1 West Indian cricketer who were bribed
- Kerala bar bribery case: Relief for Mani as anti-corruption body decides against chargesheet
- No charging check-in baggage: Government on budget airlines' move
- Delhi court allows TERI chief R K Pachauri to travel to USA
If you have recurrent memory loss of the same functions that you perform everyday, besides disorientation of time and place, chances are that you may be suffering from dementia. However, doctors at the PGIMER say that early detection can even reverse the condition and dementia can be cured.
Says Dr Prabhakar, "There is no single test that can determine if someone has Alzheimer's disease, and the diagnosis requires a full physical and neurological examination to rule out other causes of dementia".
Says Dr Modi, in order to avoid suffering from dementia or memory loss, one should stay active physically and mentally in order to prevent occurrence of dementia.
Eating foods high in Vitamin E, walnuts, green leafy vegetables has recently been shown to have a protective effect against Alzheimer's disease. There is evidence that people who have lot of mental, physical, and social stimulation have lower rates of AD.
The number of people living with dementia worldwide is currently estimated at 35.6 million. This number will double by 2030 and more than triple by 2050. Many different conditions and diseases cause dementia.
Alzheimer's Disease (AD) is a specific type of dementia. It is a progressive, degenerative disease that causes the slow decline of nerve cells in the brain. Individuals with Alzheimer's Disease experience progressive and irreversible loss in thinking abilities, including language and memory. Changes are also witnessed in mood, personality, sleep-wake cycles, and behaviour.
The average worldwide lifetime risk of developing any degenerative dementia is about 5 percent by age 65, 10 to 15 percent by age 75, and 20 to 40 percent by age 85. Individuals who have a parent with Alzheimer's disease have about twice the average risk of getting the disease, that is, among 65-year-olds with an affected parent, about 10 per cent will develop Alzheimer's disease, says Dr Modi.
... contd.


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Sunset Cocktails and (free) Live Jazz
- Music
- 420 Park Avenue South, New York, NY, 10021
What's holding up open access?
Wednesday, October 17, 2012 from 7:00 PM to 9:00 PM
In September, the high-energy physics community and 10 publishers came to an agreement: all future papers in the field would be published open access. In biology, the US government and a number of private foundations are also pushing for publications to be open access. Although there are an increasing number of open access publishing options, lots of scientific results still sit behind paywalls. Our panel will discuss the challenges faced by open access publishing platforms, and the barriers that are limiting its wider adoption. We'll also consider whether opening up the publishing process at an earlier stage could be beneficial to science. Panelists:
SpotOn NYC (#sonyc) is a monthly discussion series organised by Nature Publishing Group and Ars Technica and hosted at Rockefeller University. The organisers are Lou Woodley, John Timmer, Jeanne Garbarino and Joe Bonner.
More information about our events, including related blog posts and Storify and livestream archives can be found on the SpotOn website.
Join millions of people on Eventbrite.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Long Beach's Day Labor Marketplace
Get help moving your stuff. California day labor has never been this easy to hire.
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Using Day Labor as Move Help
If you're searching for day labor in Long Beach to help load a moving truck or get your new furniture unloaded, picking someone up off the street is a risky move. Use the HireAHelper California day laborer marketplace to quickly browse through dozens of Long Beach laborers, compare reviews and clear pricing. Then book online within a few clicks.
Now, you can hire day labor throughout Long Beach confidently (or anywhere in California), knowing your payment is securely held in escrow via HireAHelper. No more awkward confusion about how much cash to have on hand to pay workers you weren't pleased with. HireAHelper charges your credit card one day before your job date, then holds the funds in a trust until you authorize those funds be released to the Long Beach day laborers you hired.
But do they work hard?
Read reviews on all the Long Beach area helpers to find the day labor crew that works the hardest. Some of the laborers might be cheaper for a reason. Average quality work means they can't charge as much. Every HireAHelper customer gets to leave an honest review of the Long Beach move help they received from their day laborers.
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Haven't rented your moving truck or container yet? We can help! Our brand spankin new Moving 101 section has all the information you need to help you compare all your moving options and plan your move. Read real reviews and compare average pricing for local & long distance truck rentals and moving containers. Find must-know tips, tricks, & reminders to make an easier move. Plus, discover more about why making a Hybrid Move with HireAHelper will save you time & money. Happy moving!Make An Easier Move
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text: Lana Del Ray confirms how much she was paid for Kimye's wedding Thu-29-May-14 16:00 Share this Tell Us What You Think WTF 0 LOL 0 FAIL 0 OMG 0 HOT 0 CUTE 0 ] By Sharyn CaseyRumours this week have been going mental about Kimye paying 2.8 million dollars to Lana Del Ray to sing at their rehearsal dinner. Lana has come out and slammed these reports saying "I would never let a friend pay me to sing at the wedding" – so the 2.8 Million is FALSE. She did it for FREE. You May Also Like Happy 10 year wedding anniversary Jay-Jay & Dom! See the beautiful winter wedding pics Quite possibly the best Best Man's speech ever All you need to know about Kim & Kanye's wedding Become a fan of The Edge on Facebook and on Twitter .


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On the playground at Kyffin Elementary, Mia Towl's classmates like to play on the monkey bars, but Mia can only watch the other girls. Her tiny hands are too small to grasp the bars securely, and a fall from that height could be especially dangerous for her. "If I fall off the monkey bars, I could literally break an arm," said Mia, a 9-year-old who possesses vocabulary and maturity beyond her years. Soccer, the favorite sport of girls her age, also is too dangerous. Mia was born with a form of dwarfism called achondroplasia and is only 39 inches tall.
"She can't have balls hitting her head, or high impact on her head, because of the way the head connects to the spine," said her mom, Lyssa. "It's anatomically different. It's more fragile."
But Mia's limitations dissolve in the swimming pool. Swimming makes her feel free.
"I don't know what the feeling is, it just makes me feel happy," Mia said. "Happy and glad my mom signed me up."
Swimming makes her feel accomplished, too. "From not being able to do the monkey bars to be able to do something my fellow students can't do."
Mia can swim all four strokes and is training in earnest to compete in the World Dwarf Games on Aug. 4 in East Lansing, Mich. She can hardly wait — for the first time, she will get to compete with girls her age who are "little people," too. She wants to find out how good she is. She has the heart of a competitor, and she wants to win.
Mia is an athlete.
"I'm very excited for it because my other little people friends can't swim as well as I can," Mia said. "I have to stay in the shallow end if I'm with them."
Mia can't compete with average-height swimmers her age because they are so much bigger — the average 9-year-old is more than a foot taller — and she doesn't get opportunities locally to compete with little people her age. She wants to win a gold medal at the world meet.
"She's a very strong swimmer," said her coach, Laurie Hakala. "Her level in the water is perfect, and her strokes are beautiful."
When doing the butterfly, the most difficult stroke to learn, she utilizes a strong core and remarkably developed shoulder muscles.
"You have to have two kicks per one pull, and she has a little bit of drag on her feet," Hakala said. "But her trunk is so strong, she can rotate it just right and have the right timing. She's very good at fly. Very, very good."
In the winter, she finds her freedom in skiing. She typically skis 15 days a year and is a graceful intermediate who can comfortably navigate the many green and blue runs on the front side of Keystone. Her parents often bring "average-height" kids along to ski with her, and Mia holds her own.
"I like to ski because I go fast," Mia said, "and I can't go fast on my normal legs."
Home modifications
Going into the fourth grade this fall, Mia is barely the height of a typical kindergartner, and probably will be about 4 feet tall when she is an adult.
Her parents have made modifications to their Green Mountain home to accommodate her. Steps slide like drawers out of a cabinet in a bathroom so she can climb up and reach the sink to wash her face and hands. The kitchen has a "tower" she climbs so she can reach upper shelves in cabinets and the refrigerator. Her parents want Mia, an only child, to be self-reliant.
Sometimes her legs hurt when she runs. Her joints can be tender, and jumping causes pain in her knees. She has to be careful because people with achondroplasia are prone to dislocations. But she almost never feels sorry for herself. She is a cheerful child, with a smile and a spunky spirit that melt hearts.
"I think of her often because she just makes life come alive," said Hakala, who has coached Mia for three years. "She's just so free and so happy. She just never seems to get down. Always up and always makes people feel happy."
Mia's dwarfism is the result of a genetic mutation, but when her parents joined a support group for parents of little people so they could learn about dwarfism, they heard talk of the "happy gene." They're sure Mia got that one.
"We didn't understand what they meant, but there is some connection there," said Mia's father, Dean. "I don't know what it is, but little people tend to be very happy. They just have this zest for life."
Mia likes to show off how she can jump rope on one leg, and she loves to learn. Recently, she attended a kids biology summer camp at the University of Colorado at Boulder, followed by a chemistry camp at CU Denver.
"She really is academic-minded," said Lyssa. "She really enjoys it. She asked every one of her little friends to go with her to summer camp — biology and chemistry — and she didn't get one kid to join her."
She also went kayaking in the ocean with her mom, exploring sea caves in the Channel Islands near Santa Barbara, Calif. The kayak leader gave her a starfish.
"The sea star stuck to my finger. It doesn't have suckers — it has glue," said Mia, ever the science student. "It uses its own glue to glue onto things." She also learned that sea lions are really stinky, waving her hand in front of her nose comically to make the point.
Trips to the pool
Mia was born two months prematurely — unrelated to her achondroplasia — and spent her first 19 days as a newborn in the neonatal intensive care unit at Exempla St. Joseph's Hospital. That was followed by 18 months of physical therapy to improve her muscle tone.
At six months, Lyssa began taking her to the pool so she could learn to swim.
"Swimming is important for a life skill," Lyssa said. "It's a great sport for (people with achondroplasia) because it's low-impact. When you look at all the choices you have for your kids to play sports, and all of a sudden it gets really narrow, you focus on where they're going to be the most successful and safest. Then you start pursuing those pretty heavily."
Skiing is a more risky choice. Mia's parents worry about a skier or snowboarder colliding with her. Once, when Mia was 3 or 4, a snowboarder thought it would be amusing to jump over her on his board. Fortunately, she wasn't hit.
She does fall while skiing, but she doesn't have far to fall, and her balance is exceptional.
"You have to take some risks in life, and we're willing to do some of those type of things," said Dean, director of project planning for M.A. Mortenson Construction in Denver. "We don't want her to be sequestered. We want her to have the same experiences other kids have. Skiing can be more dangerous for little people, because if she falls, she has a harder time stopping her head, so she could be hurt more severely. She likes it so much and she loves sports. We like to let her have the opportunity to do those things. We try to be careful, but we like to have some fun, too."
Because of her stature, people often think she's younger than she is. When she was 4, people were shocked by the way she could walk and talk and ride a bike. Now when people see how well she can ski, they ask how old she is. When she tells them, they're incredulous.
"We get a lot of stares and double-takes," Lyssa said.
Sometimes other children ask innocent questions that can hurt. Why is Mia so short? Why is she only half as tall as me? Her parents explain that she is just like other kids except her arms and legs are shorter. The Towls don't like to call other kids "normal," preferring to describe them as "average-height" because Mia is normal in so many respects.
"For the most part, kids have been curious and very accepting," Dean said. "We've had a few incidents with teasing. She'll say occasionally, 'I don't want to be little anymore,' but for the most part, we've had great experiences."
When someone is mean to Mia — innocently or deliberately — her parents "coach" her through the experience.
"When we were in California, we went to a playground — just stop the car, get out, run around," said Lyssa, a health care consultant. "There were these two little girls that were about her age that were completely rude — staring at her, walking away, talking about her behind her back. She was very upset about it.
"You have to say, 'You have a choice. You can go play and enjoy yourself, and not let them bother you, or you can cry and be upset about it. You have to choose how you're going to respond.' "
Mia's kindergarten teacher, Kirsten Wagner, remembers being moved by her courage and a heart for fairness that was extraordinary for a child of 5.
"What struck me was her ability to advocate for herself, to stand up for herself and for her friends," Wagner said. "She's taken what she learned from her mother about herself and applied it to taking care of her friends, making sure everyone is treated fairly and everyone is kind to each other."
She's an "old soul"
Mom says Mia is an "old soul," and Dad says she's "very comfortable in her own skin." Maybe she can't play on the monkey bars or compete with the other kids at school on field days, and she will never be allowed on a roller coaster because of her size, but Mia and her parents focus on the things she can do.
She can hardly wait to compete at the World Dwarf Games, which have been held every four years since 1993. More than 400 athletes from 19 countries will compete in 13 sports, with the opening ceremony set for Aug. 3 and the closing ceremony Aug. 10.
"We're going to the world games mostly to meet other people, share in the experience," Dean said. "We're not there to win, necessarily."
Mia didn't like the sound of that at all, shooting her father a mock dirty look that was good-natured but adamant.
"Dean and I wanted Mia to swim for exercise and safety," Lyssa said. "We don't care if she competes or not, but she is a competitor. She's a fierce competitor. That's where it becomes her own."
Mia's tenacity inspires her coach, who has done more than 40 triathlons.
"She came into my life, we matched each other and she learned the skills so quickly, we just bonded," Hakala said. "She does more good for me. She's just a really hard worker, always has a positive attitude toward anything. I just look forward to being in her life for a long, long time."
Mia has that effect on people.
"She's so happy," Lyssa said. "And excited, smart, athletic. There's not anything I would change. She's a delight."
John Meyer: 303-954-1616, email@example.com or twitter.com/jmeyer26
Facts on Achondroplasia
Achondroplasia is one of approximately 200 forms of dwarfism. Abnormal cartilage formation caused by a genetic mutation prevents normal bone growth in the arms and legs, which are severely shortened. Average height in adulthood is slightly over 4 feet.
Figures on the prevalence of achondroplasia vary from one in 10,000 births to one in 40,000 because the condition is sometimes misdiagnosed. The most commonly cited figure is one in 25,000.


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I just copied some sample from book HTML5 Canvas, which loads video in the javascript and show that video on Canvas;
the Basic code is as following:
videoElement = document.createElement("video");
videoDiv = document.createElement("div");
videoElement.setAttribute("src", "url to the video");
videoElement.addEventListener("canplaythrough", videoLoaded, false);
suppose the videoLoaded should be called after when loading video, but it isn't;
I checked it in firebug, it shows that the browser just keeps loading the video, but no content fetched;
I just upgrade firefox from v17 to v18.
And it worked in V17.
Could some help me out of this? thanks.


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Ends today. At Qdoba, buy one entree and get another for Free when you mention the "mid-week buddy pass". Here's their restaurant locator.
Deal has expired
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By STEPHANIE A. JAMES
Staff Writer
A long-standing athletic symbol for Appomattox County High School may soon be no more.
With the exception of colors, it has been pointed out to the school that school's "Block A" design as part of its logo is similar to the University of Arizona's trademarked design.
Now the high school is looking to make changes to its logo design, after the similarities were pointed out by the Collegiate Licensing Corporation, a trademark licensing company that represents the university.
The corporation requested the school stop using the logo.
"We are in the process of going through changes and phasing it out. We have to change everything," said ACHS athletic director Chris Dodge.
Those changes include items such as sports merchandise and printed material. The design of the "A" is located on scoreboards on the football, baseball, and softball fields, whether it is on the school's mascot pirate or stand alone. Also, the design is located on sports uniforms, as well as on stickers on floors and walls.
Dodge said he believes that the high school has been using the "Block A" for about 10 years.
After a new logo design is established, Dodge estimates that it will take four to five years for the removal of all of the current "Block A" designs.
For the changes, there has been a plan outlined and submitted. The university's attorney already has approved the plan, according to the school division's attorney Frank Wright, who said that he is waiting for a formal letter stating the university's approval of the plan.
In that plan, it lists any items that the "Block A" is featured on.
So far, the "Block A" has been removed from all school related and social media websites.
After this year's season, school officials expect to remove the "Block A" from the back of the football helmets, when they are repainted.
In addition, clothing and items with the "Block A" on them will no longer be sold.
Other plans for removal after the new design is established include the following:
* Floor mats that have the design on them will be removed
* There will be an attempt to remove stickers on the floors of the Career and Technical Education building and gym lobby that have wax on the floors. This will be done when the floors are stripped and re-waxed during the summer of 2014.
* It will take about one to three years to replace the logo on the scoreboards, when they are painted.
Each item that has the current design will be removed depending on funding and resources, said Dodge. There is no estimate on how it would cost to replace design on the items.
Dodge said that the school division hopes to have a new logo in place before August 2014, when the new school year begins.
Prior to choosing a new logo, Dodge said school officials plan to solicit input from the community.
"We want it to be a community decision. They are the ones that support us so we want their input as well. We want it to be a true representation of Appomattox County," said Dodge.
Since the quest for the search for another logo design, school board member Wyatt Torrence has already offered about 30 new design drawings.
When the school does get a new logo, it will need to be registered with the Virginia High School League.
Before registering it, the school will need to be sure that the new design does not match other schools. An intellectual property attorney, who handles trademark issues, may handle this, said Wright.
ACHS is not alone. Licensing companies are locating similar or identical logos and sending out cease and desist letters requesting that educational institutions change its logo, if it matches another institution.
On a regional level, Liberty University requested that Lipscomb University change its logo after discovering similarities, according to media reports.
In a lot of cases, Wright said that the licensing company sues.
"Fortunately, this was not the case for Appomattox," added Wright.
This summer, ACHS principal Martha Eagle received a letter dated July 31, from James Aronowitz, attorney of the Collegiate Licensing Company, after they noticed ACHS logos on the school's website and the Raiders football Facebook page.
Aronowitz explains in the letter the university's stance on the use of the Block A design.
"Your school's use of a design that is nearly identical to the Block A design mark may cause consumers to erroneously believe that the University has authorized Appomattox County High School to use its marks. Additionally, it will dilute the distinctiveness of the mark that the public associates with the University," wrote Aronowitz. "It will also interfere with the University's ability to effectively market and license the use of the marks in the marketplace."


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- Willamette
- Alumni Association
- Alumni Weekend
- Schedule
- Athletic Events
WU Alumni Weekend
Athletic Events
Friday, Sept. 18
Volleyball vs. Linfield
7:00 p.m.
Cone Field House, Sparks Athletic Center
Cheer on the Bearcats volleyball squad as it takes on rival Linfield!
Saturday, Sept. 19
Rowing Reunion
11:00 a.m.-12:30 p.m.
The Boathouse
Come out to the boathouse and celebrate 25 years of rowing at Willamette with current rowers, past and present coaches and fellow alumni. We'll BBQ right on the dock, share some stories, then head to the football game to cheer on the Bearcats.
Homecoming Football Game
12:30-3:00 p.m.
McCulloch Stadium
Cheer on your Willamette Bearcats as they take on the Cal Lutheran Kingsmen.
Men's Soccer vs. Whitworth
2:30 p.m.
Sparks Field
Cheer on the men's soccer team as it storms the pitch to take on Whitworth.
Sunday, Sept. 20
Men's Soccer vs. Whitman
2:30 p.m.
Sparks Field
Cheer on the men's soccer team as it storms the pitch to take on Whitman.


text:
Stock Photo:
Medical tablet showing cardiogram on display and a blue stethoscope, isolated on white background.
- Image ID: 107590424
- Copyright: Stepan Kapl
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text:
|Reviews for Just for You
| hama431 chapter 10 . 12/21/2014
Update the next chapter please
| Nathalie Crystalline of Asgard chapter 10 . 8/15/2014
OMG! Please update! I can't bear the suspense!
| SilverShadow123 chapter 10 . 5/12/2014
Update update update update update update (100x)
Pleeeeeeaaaaaaassse? I'm really starting to think I'm a masochist because my heart is breaking and mending over and over again as I read this. Especially in the last chapter where you ended with, "When he literally would have done anything to make me happy."
I was just like *holds hands up* Woah, major feels trip here. Thanks so much, just please keep breaking my heart. It's not like I need it anyways ;_;
So please update soon. I'm dying here, man. I don't care if everything ends up being sunshine and rainbows and unicorns or Tragedy-esque, I just wanna know how it all ENDS. PLEASE. END MY SUFFERING.
So, yeah. I really, really, REALLY, like your story. A lot.
| applepie1989 chapter 10 . 3/30/2014
I enjoyed it greatly. :D see the next update Soo. :)
| Halfmoon 68 chapter 10 . 12/13/2012
Please Continue! This Is Really Good!
| StarrySapphire77 chapter 10 . 11/29/2012
i can't wait for the next chapter. are the enemies people from the show?
| tohaunt chapter 10 . 10/17/2012
Ummmmm... time flies doesn't it? It's already been two years... I beginning to question if your still alive;) Hehe, hopefully you are in good health and I'm not being an insensitive beoch :( I hope that some day you might look at this and continue your stories that we all enjoy immensly. I look forward to that day, cliffhanger's kill... ;)
| TheGuardian'sOfTheFishbowl chapter 10 . 10/13/2012
Oh man! Sooooo close! Please update soon Sempai! This one of my favorite stories
| Guest chapter 10 . 7/27/2012
Hey you, you need to finish this story now!
| Guest chapter 10 . 7/18/2012
Yeah post 300
You need to continue this story. I need you to continue this story please :( I will cry and kill you.
| Guest chapter 6 . 7/7/2012
Please finish this story! I like it!
| Rubellite Game chapter 10 . 6/26/2012
keep it going
| Guest chapter 5 . 6/4/2012
Finish this story please!
| Guest chapter 10 . 4/11/2012
Please continue this story.
| AkuZeku chapter 10 . 4/7/2012
Even though your last update was one and a half year ago, I really hope you will still continue this story, because it's really good, I needed to read it through even though I should be in bed ;D I've read your story "For you I'd do anything" once years ago and a second time a few month ago and I'm happy that I found out that you wrote another Yami/Yugi-story. I love your writing style and your ideas, I just wish you'd written more stories ... because I fear the best authors get older and aren't interested in writing fanfictions anymore - that's sad. I sincerely hope you haven't lost your interest. Please update someday. I promise to read it :)


text:
Ok guys, this following line was from what extremely hilarious comedy???
Ok guys, this following line was from what extremely hilarious comedy???
Seems like Something from "A Goofy Movie"?
Originally Posted by Disney Wrassler
Nope, sorry. I also forgot to mention that this is not a Disney related movie. It came out in the 60's.
Hitchhikers guide to the Galaxy
I think?
I spelled that wrong, Oh well)
Originally Posted by Tinkerbelle
No, that movie came out about a year ago, not in the 60's. Ok I hate to do this, but I will start giving hints. One of the characters was
Hmm Is it Flight of the Navigator?
No, sorry. Remember this is NOT a Disney movie. Here is another hint:Originally Posted by SummerInFL
The Great Leslie
There was a Disney actor in this movie. It was:
Keenan Wynn
"The Great Race"
BINGO, WE HAVE A WINNER!!! GOOD JOB.Originally Posted by Arnie
I was afraid nobody would have guessed that one.
Ok another question from this movie.
Who is this movie dedicated to???
Originally Posted by BULLWHIP GRIFFIN
If no one got the name of the movie what makes you think they will
get the bonus question???
Laurel and Hardy
I hear ya Redsix, but you did get it right, right on the money. BTW, are you from Downey? I grew up in Downey. Went to Warren HIgh, GO BEARS!!!Originally Posted by Redsix
Ok, another bonus question. After watching the movie several times I came across another individual who appeared in several Disney movies in the 60's. What was her name?


text:
Korean Air Lines YS-11 hijacking
|Hijacking summary
|11 December 1969
|South Korea
|51 (all)
|Flight origin
|Gangneung Airbase
|Gimpo International Airport
The Korean Air Lines YS-11 hijacking occurred on 11 December 1969. The aircraft, a Korean Air Lines NAMC YS-11 flying a domestic route from Gangneung Airbase in Gangneung, Gangwon-do to Gimpo International Airport in Seoul, was hijacked at 12:25 PM by North Korean agent Cho Ch'ang-hǔi (조창희).[1][2] It was carrying four crewmembers and 46 passengers (excluding Cho); 39 of the passengers were returned two months later, but the crew and seven passengers remained in North Korea, seen in the South as an example of North Korean abductions of South Koreans.[3]
According to passenger testimony, one of the passengers rose from his seat 10 minutes after takeoff and entered the cockpit, following which the aircraft changed direction and was joined by three Korean People's Air Force fighter jets.[4] The aircraft landed at Sǒndǒk Airfield near Wonsan at 1:18 PM.[5] North Korean soldiers boarded the aircraft afterwards, blindfolded the passengers, and instructed them to disembark.[4] The aircraft was damaged beyond repair on landing.[1] A member of the United States Air Force In South Korea was scheduled to be a passenger on the ill-fated flight, but instead caught a military transport flight at the last minute.[6]
North Korea claimed that the pilots had flown the aircraft there to protest the policies of then-President of South Korea Park Chung-hee. The passengers were subjected to attempts at indoctrination for up to four hours a day.[4] The South Korean police initially suspected that the co-pilot conspired with two North Korean agents in the hijacking.[7] The night after the hijacking, 100,000 South Koreans held a mass rally in freezing weather to protest the hijacking, and burned an effigy of Kim Il-sung.[8]
On 25 December, North Korea proposed to hold talks on the matter.[9] Talks were finally held in late January 1970.[10] Sixty-six days after the incident, North Korea released 39 of the passengers on 14 February through the Joint Security Area at Panmunjom, but kept the aircraft, crew, and remaining passengers.[11] The statements provided by the released passengers refuted North Korea's claims that the hijacking was led by the pilots; instead, they pinned the blame on one of the passengers. One man claimed to have looked out the window of the aircraft despite instructions from the North Korean guards, and saw the hijacker being driven away in a black sedan. Another passenger was reported to have become mentally deranged as a result of his captivity, and lost the ability to speak.[4]
The fate of most of the unreturned passengers has not been confirmed. They were educated, upper-class people; Song Yeong-in of the National Intelligence Service once commented that they were probably retained by North Korea specifically for their propaganda value.[12] In 1992, Oh Kil-nam claimed that the two flight attendants as well as Hwang and Gim were employed making propaganda broadcasts to the South; he also said he heard from his daughter that the captain and first officer were working for the Korean People's Air Force.[12] The mother of one of the flight attendants, Seong Gyeong-hui, was allowed to visit the North to see her daughter as part of the family reunions agreed to in the June 15th North–South Joint Declaration; during their meeting, she claimed that she and the other flight attendant Jeong Gyeong-suk remained friends and were living in the same town.[5][12]
Hwang In-cheol, the son of one of the unreturned victims Hwang Won, would go on to set up the Korean Air Flight YS-11 Families Committee in 2008 to press the South Korean government to further investigate the issue. In media comments in 2009, he stated that he felt particularly "alienated" by the mass media attention shown to the 2009 imprisonment of American journalists by North Korea, as compared to the relative lack of coverage of the fate of his father, whom he has not seen in 40 years.[13] In June 2010, he applied to the Working Group on Enforced or Involuntary Disappearances of the United Nations Human Rights Council to investigate the unreturned passengers as cases of forced disappearance; he spent six months preparing the application, with the help of his friends.[3]
The tail number of the aircraft, HL5208, was retired as a result of the incident.[14]
Hwang In-cheol eventually sued the North Korean spy who kidnapped his father. [15][16]
List of unreturned passengers and crew[edit]
All four crew, as well as seven passengers, were not returned to the South.[17]
- Yu Byeong-ha (유병하), captain
- Choe Seok-man (최석만), first officer
- Jeong Gyeong-suk (정경숙), flight attendant
- Seong Gyeong-hui (성경희), flight attendant
- Yi Dong-gi (이동기), manager of a printing company in Gangneung
- Hwang Won (황원), programme director at Munhwa Broadcasting Corporation (MBC)
- Gim Bongju (김봉주), cameraman at MBC
- Chae Heon-deok (채헌덕), doctor
- Im Cheol-su (임철수)
- Jang Ki-yeong (장기영)
- Choe Jeong-ung (최정웅)
Names are in Revised Romanization of Korean.
- ^ a b Hijacking description, Aviation Safety Network, retrieved 20 February 2009
- ^ Gim, Su-yeol (2008-12-12), "39년전 대한민국은 국민 11명을 北에 버렸다", Daily NK, retrieved 2007-07-06
- ^ a b "Son of NK Kidnap Victim Seeks UN's Help", The Dong-a Ilbo, 2010-06-10, retrieved 2010-07-07
- ^ a b c d "Freed Koreans Retell Hijacking", Milwaukee Sentinel, 1970-02-16, retrieved 2010-07-07
- ^ a b "KAL기피랍사건", Doosan Encyclopedia, 2010, retrieved 2010-07-07
- ^ "Piracy act charged by South Korea", The Bryan Times, 1969-12-11, retrieved 2010-07-07
- ^ "Copilot suspected in Korean hijacking", Los Angeles Times, 1969-12-15, retrieved 2010-07-07
- ^ "Hijacking Hit", Spokane Daily Chronicle, 1969-12-12, retrieved 2010-07-07
- ^ "Talks on Hijacking Proposed by North To South Koreans", The New York Times, 1969-12-16, retrieved 2010-07-07
- ^ "2 Sides Meet in Korea", The New York Times, 1970-01-27, retrieved 2010-07-07
- ^ "North Korea Releases 39 in Hijacking", The New York Times, 1970-02-15, retrieved 2010-07-07
- ^ a b c Um, Han-Ah (2007-10-05), "Fate of Abducted Korean Airlines Passengers Still Unclear", Open Radio for North Korea, retrieved 2010-07-07
- ^ Kim, Tae-Hong (2009-08-07), "141 Days of Hell, What about 40 Years?", The Daily NK, retrieved 2010-07-06
- ^ Kim, Rahn (2009-09-10), "Planes Have Retired Numbers", The Korea Times, retrieved 2010-07-06
- ^ https://www.koreatimes.co.kr/www/news/nation/2012/02/117_104850.html
- ^ http://english.yonhapnews.co.kr/northkorea/2012/02/14/0401000000AEN20120214011700315.HTML
- ^ "41년 만에 유엔서 재조명되는 북한의 국제범죄", Dongrip Shinmun, 2010-06-18, retrieved 2010-07-07
- Terrorist incidents in 1969
- 1969 crimes in South Korea
- 1969 in North Korea
- Aircraft hijackings
- Aviation accidents and incidents in 1969
- Aviation accidents and incidents in South Korea
- Korean Air accidents and incidents
- Terrorism in South Korea
- Kidnappings in South Korea
- Terrorism committed by North Korea
- North Korea–South Korea relations


text:
The Footballers were invited to West Bromwich Albion on the 22nd Feb to watch the match against Fulham resulting in a 1-1 draw.
Whilst there the lads were given a tour of the grounds and were given the amazing opportunity to train in the Dome!!
Aston Manor 54 King Edwards Aston 14
Congratulations to the KS4 basketball team who continued their winning streak last night with a victory over King Edwards Aston.
Special mention to Daunte Robin for representing year 8 in the KS4 basketball team, also to Hasani Simms for contributing 8 points and Osman Goni for a steady MVP performance………..Goni Style !…………. Well done to all the boys who played last night, you were a great credit to the school.
Sixth Form Intervention Evening takes place on Thursday 15th November 2012 from 4.00 pm – 6.00 pm. All parents / carers are welcome to attend Parent workshops take place at 4.30 – 5.00 pm and 5.30 – 6.00 pm. Refreshments available on the evening. If you wish to attend, please contact Mrs J Kular or Ms L Murray.
Myself and Ms Bartley took a group of Year 11 pupils to South-City College to attend Role Model Event where they had the opportunity to meet various exhibitors – local and national employers, talk to local role models about how they got to where they are today. They also had impartial careers, training and learning advice. All pupils really enjoyed this experience and now are thinking about their future.
Congratulations to Lekkari Moses, Josiah Panton and John Daley in year 7.
They have been selected to play for Aston, Saltley, Erdington and Sutton Coldfield U12's district football team.
Out of many schools from Aston, Saltley, Erdington and Sutton Coldfield these three pupils were successful over a two week trial. It's a great achievement.
Please visit our school calendar to get a view of all the up and coming events as well as all the term dates for the next two years. Please check regularly as more dates may be added.
Just added up and coming sports events
On Thursday 2nd March, Aston Manor's Debating Club sent two teams to Harborne Academy for the first round of DebateMate's Urban Debate League. Each team took part in a pre-prepared debate about the legalisation of euthanasia and an un-prepared debate about an 8pm curfew for under 16s! The 'A' team of debating veterans from last year included Reshma Begum, Ayan Abdullahi, Siham Omar, Cassandre Ndjendje and Muna Dirir. They beat teams from St Alban's Academy and Great Barr School with two excellent performances. The 'B' team, taking part in their first ever competition, included Younis Iqbal, Aleema Hoque, Jenine Smikle, Nadia Hoque and Shareen Mohammed. They did not let inexperience get in their way and beat teams from Harborne Academy and St Alban's Academy. Both teams did Aston Manor proud and are already preparing for the next round next half term!
If you are interested in taking part, learning how to argue properly and representing Aston Manor, come and see Mr O'Donoghue in E2. Debating Club runs afterschool every Monday with our University mentor from Aston University.
Following the success of our most recent Parent Workshop, our next work shop will be:
Tuesday 31st January 2012
Times: 10.45am – 12.00pm – this session will include lunch
3.30pm – 4.30pm – refreshments will be provided
If you wish to attend please fill in the attached form and return it Emma Smith in reception.
If you would like to join the Aston Manor Academy Sixth Form please fill in the application below and return to:
The AMA Sixth Form Office
We look forward to seeing you
The Y11 History trip to Goodrich Castle last week was a great success. The sun was shining and the students ate ice – cream. They also gathered information about the castle, which is required for their controlled assessment.
Thanks to the staff who helped run the trip and thanks to the students for making it an enjoyable day out.
Miss Sanghera


text:
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Bob Walls
member for 11 years, 1 month, 12 days
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I have been doing genealogy for about 15 years, and I love sharing the information that I have. That is why when you look up individuals that I have added, you will find more than birth and death information.
I have tried my best to get the right information listed on any memorials, that I have added to this site, but if you should see a mistake, or if I have submitted a memorial that you want to add corrections or a bio to, please let me know.
Transfers of all my non-relatives to you if they are related to you, upon a "polite" request.
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Nancy Hall Anderson
Walls Family
Thank you so much for the information on our Family, I am from Spencer Walls and Ann Higdon.
Would like to invite you to share my tree and see if there needs to be corrections.
Thank you ,
Nancy Hall Anderson
Added by
Nancy Hall Anderson
on Jul 06, 2015 5:26 AM
Curtis Elton Fields
Thanks for the birth month correction!
Randy O'Guin, ranny Find A Grave 47208269
Added by
on Jul 04, 2015 5:08 AM
Colleen Stokes
Wilhelmina Winterfeld Rose
Hi Bob,
This lady is my greatx3 grandmother. I have just had the church records from Zion Lutheran Church in Ottawa Lake Mich translated from the old scrip German records and some of the dates are changing for family members. Would it please transfer this grave to me? Hopefully I can link everyone up in this family. They are scattered all over Ohio and Michigan. Thank you
Added by
Colleen Stokes
on Jun 23, 2015 6:03 AM
Brenda Patten
Charley G. Phigley
Bob, Thank you so much for posting this memorial. I have been doing research on Ancestry. com for a few months and no one knew the death date of my great uncle. It's possible no one was able to find him because the family began spelling their name Phegley instead of Phigley shortly after this. His sister Luella Phegley Wilson is my grandmother.
I'm hoping you can post a picture of his headstone if there is one. I put in a request for one. His full name was Charles Gibson Phegley. His mother was Dena Bennett Phegley Schalk. I added her memorial number to his page for your review. His father was William George Washington Phegley. He's buried in a black cemetery in Caldwell Parish, Louisiana, but his headstone may have been destroyed in a fire.
Once again, thank you so much for posting, it is really appreciated.
Added by
Brenda Patten
on Jun 21, 2015 11:52 AM
Margaret C Cowles
memorial #14653547
If Tilla isn't in the "car photo" why did you put it in HER memorial? Would you like to delete it from there (the above memorial #) and place it on your mom's and Henry's?
Thanks for listening.
TTFN maragaret
Added by
Margaret C Cowles
on Jun 20, 2015 6:51 AM
Sharon Catalano
John Franklin Hicks
Thanks Bob for the DC on John. I appreciate you sending it to me. This IS my John Franklin Hicks, because he had a daughter Mary Rose Corzine, who was the informant on his DC. Although, John's father was Jesse Calvin Hicks, not John.
I like your Bio by the way. Very nice and refreshing.
Added by
Sharon Catalano
on Jun 15, 2015 5:21 AM
Sharon Catalano
John Franklin Hicks
Hi Bob,
I have a John Franklin Hicks in my tree. He is my great grandfather's son. I know John lived in Quilin in 1942, but can't track him after that.
I'm not sure this John Franklin is mine, so I was wondering where you got the info you placed on his memorial: Father listed as John Hicks and wife is Leona Hicks. Is this on his headstone?
Perhaps I can start researching from your information. I wish the Missouri death certificates were on line.
Anyway, any help you could provide would be very much appreciated.
Added by
Sharon Catalano
on Jun 14, 2015 2:49 PM
Mary Isabell Crosby
Bob thanks for pointing me in the right direction. She really is Kelly.
Her parents were Barney Kelley & Calferina Pettengill.
Then she married a Louis Pettengill and had several children with him.
Then she married Simeon Crosby.
Very confusing until you sort thru all the paperwork!
If anyone has any information on Louis Pettingill I would be grateful.
Calfernia's parents were Samuel Pettingill & Sarah Ann Baldwin.
Thanks again!
Added by
on May 16, 2015 12:18 PM
Eunice Crosby
Hi Bob,
I think Eunice Crosby's maiden name was Garnsey.
Do you have a higher res version of Simeon Wood Crosby's death cert?
Added by
on May 10, 2015 1:47 PM
Mary Isabell Crosby
Hi Bob, Just wanted to let you know I think the census that gives her maiden name as Kelly is erroneous. Her maiden name was Pettengill. Kelly was how they wrote Crosby in that particular year.
(no big but it did cause me extra research - you know how that goes, just trying to spare others the same).
Added by
on May 10, 2015 1:42 PM
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Editors' Note: The "Download Now" link directs you to the iTunes App Store, where you must continue the download process. You must have iTunes installed in order to open the link, and you must have an active iTunes account to download the application. This download may not be available in some countries.
VietTV Pro - Truyn Hnh Trc Tuyn
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Total Downloads:511
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Price:Purchase; iTunes account required.; $2.99 to buy
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From PPCLINK Mobile Software: VietTV Pro l chng trnh xem TV trn iPhone v iPod Touch th h (3Gs & 4). Vi tiu ch n gin & hiu qu chng ti mong mun mang li cho cc qu v mt phn mm cht lng ca ngi Vit.Hin ti VietTV Pro h tr xem 15 knh ph thng trn Internet: VTV1 VTV2 VTV3 VTV4 HTV1 (H Ni 1) VTC1 VTC2 VTC10 HTV7 (HCM TV 7) HTV9 (HCM TV 9) VPTV - Truyn hnh vnh phc DNTV1 - Truyn hnh ng nai 1 DNTV2 - Truyn hnh ng nai 2 THVL1 - Truyn hnh vnh long 1 THVL2 - Truyn hnh vnh long 2Chng ti mong mun nhn c nhiu ng gp ca qu v chng trnh ngy cng hon thin hn. Chng trnh yu cu Wi-Fi internet connection (cha h tr cho mng 3G). Khng h tr: iPhone 2G/3G v iPod Touch Gen 1 & Gen 2.--------------------VietTV Pro is the way to enjoy live internet TV channels.Current support 15 channels: VTV1 VTV2 VTV3 VTV4 HTV1 (H Ni 1) VTC1 VTC2 VTC10 HTV7 (HCM TV 7) HTV9 (HCM TV 9) VPTV - Truyn hnh vnh phc DNTV1 - Truyn hnh ng nai 1 DNTV2 - Truyn hnh ng nai 2 THVL1 - Truyn hnh vnh long 1 THVL2 - Truyn hnh vnh long 2 VietTV Pro requires Wi-Fi internet connection (not support 3G network). Not support devices: iPhone 2G/3G and iPod Touch Gen 1 & Gen 2.
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Arizona State Sun Devils
'Modern Family' stars stuck 1 hour in KC elevator
KANSAS CITY, Mo. (AP) - Three stars from the ABC comedy "Modern Family" got stuck in a Kansas City elevator for about an hour Friday night, delaying their appearance at a charity benefit.
Julie Bowen, Jesse Tyler Ferguson and Eric Stonestreet were in town for a fundraiser for the Boys & Girls Clubs of Greater Kansas City. Stonestreet grew up in Kansas City, Kan.
The Kansas City Star reports ( http://bit.ly/VmAe8W) the three actors were trapped in an elevator with about a dozen other people at the Sheraton Kansas City Hotel at Crown Center, where they were headlining the fundraiser.
Crews from the Kansas City Fire Department freed the group at about 10 p.m., an hour after they were scheduled to appear.
When they finally took the stage, the actors praised and thanked the Fire Department.
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
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Press release from CNW Group
Toronto Cyclists to Benefit from New Multi-Bike Parking Racks from the Coordinated Street Furniture Program
Tuesday, November 27, 2012
Toronto Cyclists to Benefit from New Multi-Bike Parking Racks from the Coordinated Street Furniture Program09:07 EST Tuesday, November 27, 2012TORONTO, Nov. 27, 2012 /CNW Telbec/ - Astral Out-of-Home, a division of Astral Media Inc. (TSX: ACM.A ACM.B), and the City of Toronto are launching a pilot program for new multi-bike parking racks that would make parking bicycles more convenient for Toronto cyclists.The pilot program is part of Astral Out-of-Home and the City of Toronto's ongoing commitment to develop street furniture solutions that make the best use of City streets. The new multi-bike rack will maximize available bicycle parking by allowing multiple bikes to be parked in each location.The program is meant to test the new style of bike rack and if adopted will be installed to supplement Toronto's iconic post-and-rings units. The new racks will expand the options currently available to the many Torontonians who choose to ride their bicycles around the City."Along with the City of Toronto we are committed to offering street furniture solutions that improve the beauty and functionality of Toronto's streets," said Luc Sabbatini, President of Astral Out-of-Home. "The new multi-bike racks will help improve the experience of the City's cyclists and is just one of the ways Astral and the City of Toronto are working to improve City streets and make Toronto's Coordinated Street Furniture Program the best in the world."The first of the new multi-bike parking racks are being installed in the following locations:138 Main StreetBloor Street West and Christie Street, northwest corner (Christie Pits)14 Roncesvalles Avenue1303 Queen Street West117 Jefferson Avenue1272 Dundas Street West589 Queen Street West401 Richmond Street WestThe Toronto Street Furniture program was launched in 2008 and provides essential street furniture elements including transit shelters, litter/recycling bins, newspaper bins and corrals, information/ wayfinding pillars, public posting columns, bicycle racks and benches across the City of Toronto. The program is fully funded by advertising and the 20 year contract has a value of $900 million for the City of Toronto in street furniture, repairs, maintenance and capital expenditures. For more information visit the Astral Out-of-Home website.Astral Out-of-Home is one of Canada's leading out-of-home advertising companies with more than 9,500 strategically-placed advertising faces in key markets in Québec, Ontario, and British Columbia. As a forward-looking company, Astral Out-of-Home has embarked on a series of green-and-clean initiatives to reduce its ecological footprint and actively participate in sustainable development.Founded in 1961, Astral is one of Canada's largest media companies. It operates several media properties—pay and specialty television, radio, out-of-home advertising and digital media properties—among the most popular in the country. Astral plays a central role in community life across the country by offering diverse, rich and vibrant programming that meets the tastes and needs of consumers and advertisers alike. To learn more about Astral, go to astral.com.SOURCE: ASTRAL MEDIA INC.For further information: Media Contacts: Amanda Santino Account Supervisor Weber Shandwick 416 642-7901 firstname.lastname@example.com Ron Hutchinson Senior Vice-President Real Estate Services, Ontario Astral Out-of-Home 416 924-6664 firstname.lastname@example.com


text:
Yes, they are talking about a government takeover of health care
This video is spreading quickly across the Internet. In their own words, via Naked Emperor News, here are Barack Obama, Jan Schakowsky, and Barney Frank exposing the true aim of the "public option." Yes, of course, it's a Trojan Horse for government-run health care and the elimination of private industry. They've been telegraphing it since the S-CHIP expansion efforts began in 2007 and Obama signed that "first step" into law in February.
Take them at their word:
Looking for an Obamacare poster for your local protest?
Obamacare poster contest: Coming to a hospital near you!; Updated with new entries
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Obama admin: Honor the spirit of Independence Day by convincing your family this gov't mandate is awesome
July 3, 2015 06:55 AM by Doug Powers
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text:
Request improved deployment...
Hi All,
I have downloaded and installed the jre update N and am pleased with the improvements so far. I have one recommendation regarding deployment. Since there have been so many issues regarding installing applications using webstart and Vista why not have an install work like an actual app but support dynamic updates the webstart provides? I found an interesting solution (on the JDIC forum http://forums.java.net/jive/thread.jspa?threadID=29833&tstart=0 ) you all might want to look at and give feedback about it. It is listed below:
I downloaded the netx software from http://jnlp.sourceforge.net/netx. This is an open source JNLP implementation. After some changes to the netx UI to use my splash page and progressbar, I wrapped it in an exe using Launch4j http://launch4j.sourceforge.net and created a setup.exe for it (I used Inno Setup).
Users run the Setup.exe on their Vista pcs to install netx. When they click the icon, netx launches the jnlp. Voila. I have a webstart enabled application running as a Vista application with full autoupdate.


text:
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