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Publications (31)96.83 Total impact
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Article: A Matched Cohort Study of Standard Chemo-Radiotherapy versus Radiotherapy Alone in Elderly Nasopharyngeal Carcinoma Patients[Show abstract] [Hide abstract]
ABSTRACT: The impact of standard chemo-radiotherapy (CRT) as preferred therapy for elderly patients (age≥60 years) with nasopharyngeal carcinoma (NPC) remains unclear. Therefore, a strict matched cohort study was conducted to compare the survival and treatment toxicity of standard chemo-radiotherapy in the elderly NPC patients with those of radiotherapy (RT) alone. From 1998 to 2003, total 498 newly diagnosed elderly non-metastatic NPC patients were abstracted and classified into two groups by the treatments they received. For each patient in the CRT group, a matched pair in RT group was identified by matching for gender, age, histological type, T and N classifications, RT dose to primary tumor and neck nodes, and days of radiotherapy. Treatment tolerability and toxicity were clarified, and treatment outcomes were calculated and compared between the two groups. Two groups were well balanced in clinical characteristics because of the strict matching conditions. Totally 87 pairs can be assessed according to the criteria. The 5-year OS, CSS, FFS, and LR-FFS for CRT and RT groups were 62% versus 40% (P=0.013), 67% versus 47% (P=0.018), 65% versus 53% (log-rank: P=0.064, Breslow: P=0.048), and 88% versus 72%, (P=0.019), respectively. There was no significant difference in 5-year D-FFS between the two groups (75% vs. 73%, P=0.456). The CRT group experienced significantly more Grade ≥3 acute mucositis (46.0% vs. 28.7%, P= 0.019). We concluded that standard chemo-radiotherapy can achieve a reasonable local and regional control in elderly NPC patients with acceptable and reversible acute toxicity. However, distant metastasis remains the dominant failure pattern. When the elderly NPC patients are in good performance status following a complete evaluation of overall functional status and comorbidity conditions, standard chemo-radiotherapy is worthy of recommendation.PLoS ONE 03/2015; 10(3):e0119593. DOI:10.1371/journal.pone.0119593 · 3.53 Impact Factor
Article: WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis.[Show abstract] [Hide abstract]
ABSTRACT: Nasopharyngeal carcinoma (NPC) has the highest metastasis rate among head and neck cancers with unclear mechanism. WNT5A belongs to the WNT family of cysteine-rich secreted glycoproteins. Our previous high-throughput gene expression profiling revealed that WNT5A was up-regulated in highly metastatic cells. In the present study, we first confirmed the elevated expression of WNT5A in metastatic NPC tissues at both the mRNA and protein levels. We then found that WNT5A promoted epithelial-mesenchymal transition (EMT) in NPC cells, induced the accumulation of CD24-CD44+ cells and side population, which are believed to be cancer stem cell characteristics. Moreover, WNT5A promoted the migration and invasion of NPC cells in vitro, while in vivo treatment with recombinant WNT5A promoted lung metastasis. Knocking down WNT5A diminished NPC tumorigenesis in vivo. When elevated expression of WNT5A coincided with the elevated expression of vimentin in the primary NPC, the patients had a poorer prognosis. Among major signaling pathways, protein kinase C (PKC) signaling was activated by WNT5A in NPC cells. A positive feedback loop between WNT5A and phospho-PKC to promote EMT was also revealed. Taken together, these data suggest that WNT5A is an important molecule in promoting stem cell characteristics in NPC, leading to tumorigenesis and metastasis.Oncotarget 03/2015; · 6.63 Impact Factor
Dataset: journal.pone.0100843
Article: Downregulation of Ras Association Domain Family Member 6 (RASSF6) Underlies the Treatment Resistance of Highly Metastatic Nasopharyngeal Carcinoma Cells[Show abstract] [Hide abstract]
ABSTRACT: Radiation and cisplatin-based chemotherapy are major treatments for nasopharyngeal carcinoma (NPC). However, a major impediment for further improving the cure rate is the development of treatment resistance with an undetermined molecular mechanism in metastatic NPC cells. Our established, highly metastatic NPC cells have been reported to be more resistant to cisplatin chemotherapy. In the present study, we found that Ras association domain family member 6 (RASSF6) was downregulated in highly metastatic cells but upregulated in low metastatic cells in comparison to their parental cell line. Ectopic-expression of RASSF6 enhanced the sensitivity of highly metastatic NPC cells to cisplatin or radiation by enhancing apoptosis. RASSF6 depletion conversely reduced treatment sensitivity by decreasing the apoptosis rate. Over-expression of RASSF6 in highly metastatic NPC cells could enhance the phosphorylation of JNK when exposed to cisplatin or radiation treatment, while knocking down RASSF6 in low metastatic NPC cells could reduce the level of phospho-JNK when exposed to the same treatments. The activation of JNK signaling by RASSF6 and its subsequent sensitivity to apoptosis in NPC cells could be inhibited by applying the JNK inhibitor SP600125. In conclusion, the downregulation of RASSF6 in highly metastatic NPC cells contributed to their treatment resistance, and over-expression of RASSF6 conferred treatment sensitivity to highly metastatic NPC cells by activating JNK signaling. RASSF6 could be a valuable molecular marker for identifying sensitive metastatic NPC tumors during cisplatin treatment or radiotherapy.PLoS ONE 07/2014; 9(7):e100843. DOI:10.1371/journal.pone.0100843 · 3.53 Impact Factor
Article: Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis[Show abstract] [Hide abstract]
ABSTRACT: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in southern China and Southeast Asia, with the highest metastasis rate among head and neck cancers. The mechanisms underlying NPC progression remain poorly understood. Genome-wide expression profiling on 18 NPC vs. 18 noncancerous nasopharyngeal tissues together with GeneGo pathway analysis and expression verification in NPC cells and tissues revealed a potential role of urokinase-type plasminogen activator receptor (uPAR) in NPC progression, which has not been investigated in NPC. We then observed that uPAR expression is increased in poorly differentiated, highly metastatic NPC cells compared with lowly metastatic cells or differentiated NPC cells. In vitro studies demonstrated that uPAR regulates NPC cell growth, colony formation, migration, and invasion and promotes the epithelial-mesenchymal transition (EMT). Additional tumor xenograft and spontaneous metastasis experiments revealed that uPAR promotes NPC cell growth and metastasis in vivo. The JAK-STAT pathway is involved in uPAR-regulated signaling in NPC cells as determined by immunoblotting. Moreover, uPAR-mediated growth and motility is partially abolished upon treatment with the Jak1/Jak2 inhibitor INCB018424. We suppressed uPA expression in uPAR-overexpressing NPC cells and found that uPAR-mediated cellular growth and motility is not exclusively dependent on uPA. In summary, uPAR is a significant regulator of NPC progression and could serve as a promising therapeutic target.Cell cycle (Georgetown, Tex.) 04/2014; 13(12). DOI:10.4161/cc.28921 · 5.01 Impact Factor
Article: Genetic Variations in Radiation and Chemotherapy Drug Action Pathways and Survival in locoregionally Advanced Nasopharyngeal Carcinoma Treated with Chemoradiotherapy.[Show abstract] [Hide abstract]
ABSTRACT: Treatment outcomes vary greatly in patients with nasopharyngeal carcinoma (NPC). The purpose of this study is to evaluate the influence of radiation and chemotherapy drug action pathway gene polymorphisms on the survival of patients with locoregionally advanced NPC treated with cisplatin- and fluorouracil-based chemoradiotherapy. Four hundred twenty-one consecutive patients with locoregionally advanced NPC were prospectively recruited. We utilized a pathway approach and examined 18 polymorphisms in 13 major genes. Polymorphisms were detected using the LDR-PCR technique. Multifactor dimensionality reduction (MDR) analysis was performed to detect potential gene-gene interaction. After adjustment for clinicopathological characteristics, overall survival was significantly decreased in patients with the MPO rs2243828 CT/CC genotype (HR=2.453, 95% CI, 1.687-3.566, P<0.001). The ERCC1 rs3212986 CC (HR=1.711, 95% CI, 1.135-2.579, P=0.010), MDM2 rs2279744 GT/GG (HR=1.743, 95% CI, 1.086-2.798, P=0.021), MPO rs2243828 CT/CC (HR=3.184, 95% CI, 2.261-4.483, P<0.001) and ABCB1 rs2032582 AT/AA (HR=1.997, 95% CI, 1.086-3.670, P=0.026) genotypes were associated with poor progression-free survival. Prognostic score models based on independent prognostic factors successfully classified patients into low-, intermediate-, and high-risk groups. Furthermore, MDR analysis showed no significant interaction between polymorphisms. Four single nucleotide polymorphisms were associated with survival in patients with locoregionally advanced NPC treated with cisplatin- and fluorouracil-based chemoradiotherapy. Combining clinical prognostic factors with genetic information was valuable in identifying patients with different risk.PLoS ONE 12/2013; 8(12):e82750. DOI:10.1371/journal.pone.0082750 · 3.53 Impact Factor
Article: Functional polymorphisms of matrix metalloproteinase-9 and survival in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy[Show abstract] [Hide abstract]
ABSTRACT: To investigate the prognostic role of major matrix metalloproteinase (MMP) gene polymorphisms in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated with chemoradiotherapy. Four hundred twenty-one consecutive NPC patients were prospectively recruited. Two hundred patients were randomly selected as the training cohort, and the remaining 221 patients were the validation cohort. Twelve polymorphisms in the MMP-1, 2, 3, 7, 8, and 9 genes were genotyped by ligase detection reaction-PCR. MMP-9 rs2250889 PR/RR (HR = 2.287, 95 % CI 1.400-3.735) and rs17576 RQ/QQ (HR = 2.347, 95 % CI 1.431-3.849) genotypes were significantly related with increased death risk in the training cohort. Analysis of the validation cohort confirmed these results (rs2250889: HR = 2.231, 95 % CI 1.281-3.886; rs17576: HR = 2.987, 95 % CI 1.674-5.330). Multivariate analysis showed that rs17576 (HR = 2.284, 95 % CI 1.123-4.643, P = 0.023) was still an independent prognostic factor. The MMP-9 rs17576 is a novel independent prognostic marker in patients with locoregionally advanced NPC treated with chemoradiotherapy.Medical Oncology 12/2013; 30(4):685. DOI:10.1007/s12032-013-0685-6 · 2.06 Impact Factor
Article: The Impact of Baseline Serum C-Reactive Protein and C-Reactive Protein Kinetics on the Prognosis of Metastatic Nasopharyngeal Carcinoma Patients Treated with Palliative Chemotherapy[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to determine whether baseline C-reactive protein (CRP) levels and CRP kinetics predict the overall survival in metastatic nasopharyngeal carcinoma (mNPC) patients. A total of 116 mNPC patients from January 2006 to July 2011 were retrospectively reviewed. Serum CRP level was measured at baseline and thereafter at the start of each palliative chemotherapy cycle for all patients. Patients with higher values of baseline CRP (≥ 3.4 mg/L) had significantly worse survival than those with lower baseline CRP values (< 3.4 mg/L). Patients were divided into four groups according to baseline CRP and CRP kinetics: (1) patients whose CRP < 3.4 mg/L and never elevated during treatment; (2) patients whose CRP < 3.4 mg/L and elevated at least one time during treatment; (3) patients whose CRP ≥ 3.4 mg/L and normalized at least one time during treatment; and (4) patients whose CRP ≥ 3.4 mg/L and never normalized during treatment. The patients were further assigned to non-elevated, elevated, normalized, and non-normalized CRP groups. Overall survival rates were significantly different among the four groups, with three-year survival rates of 68%, 41%, 33%, and 0.03% for non-elevated, elevated, normalized, and non-normalized CRP groups respectively. When compared with the non-elevated group, hazard ratios of death were 1.69, 2.57, and 10.34 in the normalized, elevated, and non-normalized groups (P < 0.001). Baseline CRP and CRP kinetics may be useful to predict the prognosis of metastatic NPC patients treated with palliative chemotherapy and facilitate individualized treatment. A prospective study to validate this prognostic model is still needed however.PLoS ONE 10/2013; 8(10):e76958. DOI:10.1371/journal.pone.0076958 · 3.53 Impact Factor
Article: Prospective Study of Tailoring Whole-Body Dual-Modality [F-18] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography With Plasma Epstein-Barr Virus DNA for Detecting Distant Metastasis in Endemic Nasopharyngeal Carcinoma at Initial Staging[Show abstract] [Hide abstract]
ABSTRACT: PURPOSETo evaluate which patients with nasopharyngeal carcinoma (NPC) obtained the greatest benefits from the detection of distant metastasis with [(18)F]fluorodeoxyglucose positron emission tomography and computed tomography (PET/CT) combined with plasma Epstein-Barr virus (EBV) DNA levels. PATIENTS AND METHODS Consecutive patients with NPC were prospectively enrolled. PET/CT, conventional work-up (CWU), and quantification of plasma EBV DNA were performed before treatment. The accuracy of these strategies for distant metastases was assessed. The costs of the diagnostic strategies were compared.ResultsEighty-six (14.8%) of the 583 eligible patients were found to have distant metastases; 71 patients (82.6%) by PET/CT and 31 patients (36.0%) by CWU. In the multivariable analysis, advanced N stage (odds ratio, 2.689; 95% CI, 1.894 to 3.818) and pretreatment EBV DNA level (odds ratio, 3.344; 95% CI, 1.825 to 6.126) were significant risk factors for distant metastases. PET/CT was not superior to CWU for detecting distant metastases in very low-risk patients (N0-1 with EBV DNA < 4,000 copies/mL; P = .062), but was superior for the low-risk patients (N0-1 with EBV DNA ≥ 4,000 copies/mL and N2-3 with EBV DNA < 4,000 copies/mL; P = .039) and intermediate-risk patients (N2-3 disease with EBV DNA ≥ 4,000 copies/mL; P < .001). The corresponding patient management changes based on PET/CT were 2.9%, 6.3%, and 16.5%, respectively. The costs per true-positive case detected by PET/CT among these groups were ¥324,138 (≈$47,458), ¥96,907 (≈$14,188), and ¥34,182 (≈$5,005), respectively. CONCLUSIONPET/CT detects more distant metastases than conventional staging in patients with NPC. The largest benefit in terms of cost and patient management was observed in the subgroup with N2-3 disease and EBV DNA ≥ 4,000 copies/mL.Journal of Clinical Oncology 07/2013; 31(23). DOI:10.1200/JCO.2012.46.0816 · 17.88 Impact Factor
Article: A prognostic model predicts the risk of distant metastasis and death for patients with nasopharyngeal carcinoma based on pre-treatment serum C-reactive protein and N-classification[Show abstract] [Hide abstract]
ABSTRACT: PURPOSE: Chronic inflammation plays an important role in nasopharyngeal carcinoma (NPC) development and progression. Aim of this study is to determine whether inflammation-related parameters predict distant metastasis in NPC patients. MATERIALS AND METHODS: 335 newly diagnosed non-metastatic NPC patients were recruited. The values of the C-reactive protein (CRP), lactate dehydrogenase, albumin, globulin, white blood cell and neutrophil at baseline were measured. RESULTS: Among the above six parameters, only CRP was independently associated with distant metastasis-free survival (DMFS). CRP concentration of advanced T-/TNM-classification patients was higher than those with early classification (P=0.001). Higher-CRP (CRP⩾2.46mg/L) predicted shorter overall survival, disease-free survival and DMFS than lower-CRP (CRP<2.46mg/L). In a multivariable model, higher-CRP and advanced N-classification were independent predictors of distant metastasis. On the basis of these two parameters, a prognostic NC-model was developed as following: (1) low-risk (early N-classification and lower-CRP); (2) intermediate-risk (advanced N-classification or higher-CRP) and (3) the high-risk distant metastasis (advanced N-classification and higher-CRP). When compared with the low-risk group, the hazard ratios (HRs) for distant metastasis and death for the intermediate-/high-risk patients were 3.6/16.1 and 2.26/7.61, respectively (both P<0.001). CONCLUSION: We developed a new prognostic model based on CRP and N-classification for predicting distant metastasis and death of NPC patients, which may facilitate patient counselling and individualised treatment.European journal of cancer (Oxford, England: 1990) 04/2013; 49(9). DOI:10.1016/j.ejca.2013.03.003 · 4.82 Impact Factor
Article: Prospective study of prognostic value of Raf kinase inhibitory protein and pretreatment plasma Epstein-Barr virus DNA for distant metastasis in locoregionally advanced nasopharyngeal carcinoma[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: The purpose of this prospective study was to investigate the predictive significance of Raf kinase inhibitory protein (RKIP) in locoregionally advanced nasopharyngeal carcinoma (NPC) and its effect on distant metastasis. METHODS: The usual immunohistochemical stainings were performed to detect RKIP expression of cancer tissues from 210 patients with advanced NPC. After DNA samples from pretreatment plasma from these patients were extracted, real-time polymerase chain reaction (PCR) was performed to quantitatively analyze plasma Epstein-Barr virus (EBV) DNA. RESULTS: RKIP expression was significantly different for different N classifications and WHO pathologic grades, respectively (p < .05). Cox regression confirmed RKIP and EBV DNA were independent prognostic markers for 5-year distant metastasis-free survival (DMFS). In the high RKIP expression group, chemotherapy had a positive effect on improved DMFS, but not in the low RKIP expression group. CONCLUSIONS: RKIP could be identified as an independent prognostic factor on DMFS. For each combined treatment modality, the different impact of chemotherapy on distant metastasis might be related to the RKIP expression level. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.Head & Neck 04/2013; 35(4). DOI:10.1002/hed.23009 · 3.01 Impact Factor
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ABSTRACT: The female sex is traditionally considered a favorable prognostic factor for nasopharyngeal carcinoma (NPC). However, no particular study has reported this difference. To explore the prognostic impact of gender in patients with NPC after definitive radiotherapy, we reviewed the clinical data of 2063 consecutive patients treated between 1st January 2000 and 31st December 2003 in the Sun Yat-sen University Cancer Center. The median follow-up for the whole series was 81 months. The female and male patients with early stage disease comprised 49.4% and 28.1% of the patient population, respectively. Both the 5-year overall survival (OS) and disease-specific survival (DSS) rates of the female patients were significantly higher than those of the male patients (OS: 79% vs. 69%, P < 0.001; DSS: 81% vs. 70%, P < 0.001). For patients with locoregionally advanced NPC, the 5-year OS and DSS rates of female vs. male patients were 74% vs. 63% (P < 0.001) and 76% vs. 64%, respectively (P < 0.001). A multivariate analysis showed that gender, age, and the TNM staging system were the independent prognostic factors for the 5-year OS and DSS of NPC patients. The favorable survival of female patients is not only attributed to the early diagnosis and treatment but might also be attributed to some intrinsic feature of female patients.Chinese journal of cancer 09/2012; 32(5). DOI:10.5732/cjc.012.10058
Article: As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial–mesenchymal transition and activation of AKT signaling[Show abstract] [Hide abstract]
ABSTRACT: Nasopharyngeal carcinoma (NPC) has the highest metastatic potential among head and neck cancers. Distant metastasis is the major cause of treatment failure. The role of interleukin-8 (IL-8) in NPC progression remains unknown. Our multivariate survival analyses of 255 patients with NPC revealed that higher IL-8 expression in primary NPC tissue was an independent prognostic factor for overall survival, disease-free survival, and distant metastasis-free survival of the patients. In vitro study revealed that IL-8 was highly expressed in the established high-metastasis NPC clone S18 relative to the low-metastasis cells. Suppression of IL-8 by short-hairpin RNA reduced the expression of IL-8 in S18 cells and subsequently inhibited migration, invasion, and hepatic metastasis of the cells without influencing cellular growth. Overexpression of IL-8 in S26 cells resulted in increased migration, invasion, and metastasis capabilities of the cells without affecting cellular growth. Exogenous IL-8 enhanced the migration and invasion of low-metastasis CNE-2 cells in a dose-dependent manner. An epithelial-mesenchymal transition (EMT) could be induced by IL-8 in various NPC cell lines. The high level of phosphorylated AKT in S18 cells could be suppressed by knocking down IL-8 expression. Further, IL-8-promoted migration and invasion could be abolished by either the application of the phosphoinositide-3-kinase inhibitor LY294002 or the knock down of AKT expression by using small-interfering RNA. In summary, IL-8 serves as an independent prognostic indicator of overall survival, disease-free survival, and metastasis-free survival for patients with NPC. IL-8 promotes NPC metastasis via autocrine and paracrine means, involving activation of AKT signaling and inducing EMT in NPC cells.Carcinogenesis 05/2012; 33(7):1302-9. DOI:10.1093/carcin/bgs181 · 5.27 Impact Factor
Article: A randomized trial of induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus radiotherapy for locoregionally advanced nasopharyngeal carcinoma[Show abstract] [Hide abstract]
ABSTRACT: The aim of this randomized study was to compare the efficacy of induction chemotherapy plus concurrent chemoradiotherapy (IC+CCRT) versus induction chemotherapy plus radiotherapy (IC+RT) for patients with locoregionally advanced nasopharyngeal carcinoma. From August 2002 to April 2005, 408 patients were randomly divided into two groups: an IC+CCRT group and an IC+RT group. Patients in both groups received the same induction chemotherapy: two cycles of floxuridine (FuDR)+carboplatin (FuDR, 750mg/m(2), d1-5; carboplatin, area under the curve [AUC]=6). The patients received radiotherapy 1week after they finished the induction chemotherapy. The patients in the IC+CCRT group also received carboplatin (AUC=6) on days 7, 28, and 49 of radiotherapy. Eight patients did not meet the inclusion criteria, and the remaining 400 cases were analyzed. Grade III or IV toxicity was found in 28.4% of the patients in the IC+CCRT group and 13.1% of those in the IC+RT group (P<.001). Five-year overall survival rates were 70.3% and 71.7% (P=0.734) in the IC+CCRT and IC+RT groups, respectively. No significant differences in failure-free survival, locoregional control, and distant control were found between the two groups. Compared with the IC+RT program, the IC+CCRT program used in the present study did not improve the overall survival and failure-free survival in patients with locoregionally advanced nasopharyngeal carcinoma. Using carboplatin in the concurrent chemoradiotherapy was not suitable for nasopharyngeal carcinoma.Oral Oncology 05/2012; 48(10):1038-44. DOI:10.1016/j.oraloncology.2012.04.006 · 3.03 Impact Factor
Article: A Posteriorly Pedicled Middle Turbinate Mucoperiosteal Flap Resurfacing Nasopharynx after Endoscopic Nasopharyngectomy for Recurrent Nasopharyngeal CarcinomaOtolaryngology Head and Neck Surgery 03/2012; 146(3):409-11. DOI:10.1177/0194599811430918 · 1.72 Impact Factor
Article: Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial.[Show abstract] [Hide abstract]
ABSTRACT: Concurrent chemoradiotherapy (CCRT) has been shown to improve outcomes for stage III-IV nasopharyngeal carcinoma (NPC) patients compared with radiotherapy (RT) alone, but the effectiveness of the combined therapy for stage II NPC patients is unknown. Patients with Chinese 1992 stage II NPC were randomly assigned to receive either RT alone (n = 114) or CCRT (n = 116). The CCRT patients were given concurrent cisplatin (30 mg/m(2) on day 1) weekly during RT. The primary endpoint was overall survival (OS). Secondary endpoints were progression-free survival (PFS), distant metastasis-free survival, and locoregional relapse-free survival. All patients were analyzed by the intent-to-treat principle. The Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) and in multivariable analyses to test the independent statistical significance of treatment intervention. Toxic effects and the response to treatment were analyzed using the χ(2) test. All statistical tests were two-sided. With a median follow-up of 60 months, adding chemotherapy statistically significantly improved the 5-year OS rate (94.5% vs 85.8%; HR of death = 0.30, 95% CI = 0.12 to 0.76; P = .007), PFS (87.9% vs 77.8%; HR of progression = 0.45, 95% CI = 0.23 to 0.88; P = .017), and distant metastasis-free survival (94.8% vs 83.9%; HR of distant relapse = 0.27, 95% CI = 0.10 to 0.74; P = .007); however, there was no statistically significant difference in the 5-year locoregional relapse-free survival rate (93.0% vs 91.1%; HR of locoregional relapse = 0.61, 95% CI = 0.25 to 1.51; P = .29). Multivariable analysis showed that the number of chemotherapy cycles was the only independent factor that was associated with OS, PFS, and distant control in stage II NPC. The CCRT arm experienced statistically significantly more acute toxic effects (P = .001), although the rate of late toxic effects did not increase statistically significantly. Concurrent chemotherapy and radiotherapy is associated with a considerable survival benefit for patients with stage II NPC.CancerSpectrum Knowledge Environment 11/2011; 103(23):1761-70. DOI:10.1093/jnci/djr432 · 15.16 Impact Factor
Article: Prospective validation of the prognostic value of elevated serum vascular endothelial growth factor in patients with nasopharyngeal carcinoma: More distant metastases and shorter overall survival after treatment[Show abstract] [Hide abstract]
ABSTRACT: The purpose of this prospective study was to investigate the prognostic value of serum vascular endothelial growth factor (sVEGF) in patients with nasopharyngeal carcinoma (NPC). sVEGF was prospectively detected in 306 patients with NPC with enzyme-linked immunosorbent assay before treatment. The correlations between sVEGF and the survival of these patients were evaluated. Patients were followed for at least 36 months. The mean sVEGF was 387.0 ng/L. sVEGF showed no difference in sex, age, and local recurrence. However, sVEGF was positively associated with histology, TNM classification, distant metastasis, and overall survival (OS; p < .05). The 4-year OS and distant metastasis-free survival (DMFS) of the high-sVEGF versus low-sVEGF groups were 68% versus 86% and 70% versus 89%, respectively (p < .05). Stratified analysis showed that patients with stage IV(a,b) , T(4) , N(1) , or N(positive) disease with high VEGF levels had worse 4-year OS and 4-year DMFS than those with low VEGF levels (p < .05). Multifactorial Cox regression confirmed sVEGF was among the independent prognostic factors. Elevation of sVEGF in patients with NPC predicts more posttreatment distant metastases and shorter OS and can be used as an independent poor prognostic indicator.Head & Neck 06/2011; 33(6):780-5. DOI:10.1002/hed.21541 · 3.01 Impact Factor
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ABSTRACT: Nasopharyngeal carcinoma (NPC) is known for its high-metastatic potential. Here we report the identification of the proteoglycan serglycin as a functionally significant regulator of metastasis in this setting. Comparative genomic expression profiling of NPC cell line clones with high- and low-metastatic potential revealed the serglycin gene (SRGN) as one of the most upregulated genes in highly metastatic cells. RNAi-mediated inhibition of serglycin expression blocked serglycin secretion and the invasive motility of highly metastatic cells, reducing metastatic capacity in vivo. Conversely, serglycin overexpression in poorly metastatic cells increased their motile behavior and metastatic capacity in vivo. Growth rate was not influenced by serglycin in either highly or poorly metastatic cells. Secreted but not bacterial recombinant serglycin promoted motile behavior, suggesting a critical role for glycosylation in serglycin activity. Serglycin inhibition was associated with reduced expression of vimentin but not other epithelial-mesenchymal transition proteins. In clinical specimens, serglycin expression was elevated significantly in liver metastases from NPC relative to primary NPC tumors. We evaluated the prognostic value of serglycin by immunohistochemical staining of tissue microarrays from 263 NPC patients followed by multivariate analyses. High serglycin expression in primary NPC was found to be an unfavorable independent indicator of distant metastasis-free and disease-free survival. Our findings establish that glycosylated serglycin regulates NPC metastasis via autocrine and paracrine routes, and that it serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in NPC patients.Cancer Research 02/2011; 71(8):3162-72. DOI:10.1158/0008-5472.CAN-10-3557 · 9.28 Impact Factor
Article: Serum CCL2 and serum TNF-α – Two new biomarkers predict bone invasion, post-treatment distant metastasis and poor overall survival in nasopharyngeal carcinoma[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the prognostic potential of serum CCL2 (sCCL2) and serum TNF-α (sTNF-α) in nasopharyngeal carcinoma (NPC) before treatment by analysing the expression of these two markers. Both sCCL2 and sTNF-α were prospectively detected in 297 NPC patients with enzyme-linked immunosorbent assay (ELISA) before treatment. The correlations between sCCL2 level or sTNF-α level and patient's survival were evaluated. For sCCL2, the 5-year overall survival (OS) and 5-year distant metastasis-free survival (DMFS) of high expression group and low expression group were 64% versus 81% and 67% versus 84% (P < 0.05), respectively. For sTNF-α, the 5-year OS and 5-year DMFS of high expression group and low expression group were 62% versus 79% and 66% versus 82% (P < 0.05), respectively. The 5-year OS and 5-year DMFS for both positive patients, one marker positive patient and both negative patients were 53% versus 77% versus 85% and 58% versus 80% versus 86% (P < 0.05), respectively. Concentrations of sCCL2 and sTNF-α in patients with large skull base invasion were higher than those without or with small skull invasion (P < 0.05). Patients who developed bone metastasis alone after radical treatment had higher pre-treatment concentrations of sCCL2 and sTNF-α than those without metastasis (P < 0.001). Multifactorial Cox regression analyses demonstrated that T/N/M classification, chemotherapy, sCCL2 level and sTNF-α level were independent predictors of OS and DMFS of NPC patients. High expression levels of sCCL2 and sTNF-α predict bone invasion, post-treatment distant metastasis and poor overall survival in NPC patients.European journal of cancer (Oxford, England: 1990) 10/2010; 47(3):339-46. DOI:10.1016/j.ejca.2010.09.025 · 4.82 Impact Factor
Article: Detection of nasopharyngeal carcinoma using surface-enhanced laser desorption and ionization mass spectrometry profiles of the serum proteome.[Show abstract] [Hide abstract]
ABSTRACT: Early diagnosis of nasopharyngeal carcinoma (NPC) is difficult due to the insufficient specificity of the conventional examination method. This study was to investigate potential and consistent biomarkers for NPC, particularly for early detection of NPC. A proteomic pattern was identified in a training set (134 NPC patients and 73 control individuals) using the surface-enhanced laser desorption and ionization-mass spectrometry (SELDI-MS), and used to screen the test set (44 NPC patients and 25 control individuals) to determine the screening accuracy. To confirm the accuracy, it was used to test another group of 52 NPC patients and 32 healthy individuals at 6 months later. Eight proteomic biomarkers with top-scored peak mass/charge ratios (m/z) of 8605 Da, 5320 Da, 5355 Da, 5380 Da, 5336 Da, 2791 Da, 7154 Da, and 9366 Da were selected as the potential biomarkers of NPC with a sensitivity of 90.9% (40/44) and a specificity of 92.0% (23/25). The performance was better than the current diagnostic method by using the Epstein-Barr virus (EBV) capsid antigen IgA antibodies (VCA/IgA). Similar sensitivity (88.5%) and specificity (90.6%) were achieved in another group of 84 samples. SELDI-MS profiling might be a potential tool to identify patients with NPC, particularly at early clinical stages.Chinese journal of cancer 08/2010; 29(8):721-8. DOI:10.5732/cjc.010.10037
Top Journals
Sun Yat-Sen University Cancer Center
Shengcheng, Guangdong, China
- Department of Radiation Oncology
Sun Yat-Sen UniversityShengcheng, Guangdong, China


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
27 year old man | San Francisco, CA, USA | Seeking women 21-28 within 7 miles
Outdoorsy guy with a gentle disposition. Thoughtful and optimistic.
I'm an East Coast transplant, born and raised in the suburbs of Philadelphia. I came to the Bay Area for college and never looked back. I spend my weekdays in front of a computer earning my living, but find myself happiest while surrounded by the beauty of nature. The coastal cliffs and rocky beaches of the Sonoma Coast never fail to inspire me. I try to lead a mindful life, and invest a fair amount of energy in learning and improving myself. Though I love the outdoors, I don't expect my partner to share my passion to the same degree. That being said, she should at least be willing to go hiking or camping once in awhile. I'm looking primarily for an open-minded person who can contribute her own perspective to an intellectually stimulating conversation. Someone who I can learn from, and someone who can appreciate what I have to offer.
Book club , Camping , Coffee and conversation , Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Playing sports , Political interests , Travel/Sightseeing , Wine tasting
Cycling, Running, Swimming, Walking / Hiking
I exercise 3-4 times per week.
I don't believe in astrology
I like Cats, Dogs
Love dogs, but allergic to them.
Trouble Coffee, Bi-Rite, Green Apple Books, King of Noodles, Arizmendi Bakery, Mt. Sutro, Golden Gate Park, Mt. Tam
Stanford University, Stanford, CA
Movies: The Graduate, The Princess Bride, Rushmore, Burn After Reading Books: The Bonfire of the Vanities, Rabbit Run, Buddhism Without Beliefs Music: Bob Dylan, Neil Young, M. Ward, Wilco, Yo La Tengo, Elliott Smith TV: The Wire, Twin Peaks
Bicycles are my primary passion -- riding, building, maintaining and appraising them.
Blood Meridian The Adventures of Augie March
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'7" (170cms)
|5'0" (152cms) to 5'7" (170cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned
|No preference
|No preference
|No Way
|No preference
|Social Drinker
|No preference
|Technical / Science / Computers / Engineering
|No preference
|I'll tell you later
|No preference
|Never Married
|Never Married
|Have kids:
|Wants kids:
|I'll tell you later
|No preference
|Asian, East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian
|Spiritual but not religious
|No preference
Buddhism Without Beliefs, a book by a former Tibetan Buddhist monk, outlines a philosophy I am very much aligned with. It's essentially the practice of Buddhism, but stripped of all the elements of dogma and mysticism.
|Graduate degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral

subset: commoncrawl


text:
Request a Deal
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People make it happen. Spread the word to request a deal!
2 signed up for this.
From Our Editors
The Woodcraft name stretches from coast to coast with locations peppered throughout the United States, ensuring that Americans are well equipped with the brand-name tools and woodworking supplies needed to pursue handyman endeavors. At Woodcraft of Birmingham, a collection of hand tools waits patiently to hammer down nails and saw brave magician assistants in half, and a variety of power tools—including drills, sanders, and grinders—adds electric oomph to construction projects. In addition to performing in-store demonstrations of new products, the shop's wise whittlers call upon more than 80 years of collective knowledge to lead various crafts classes, in which participants learn how to carve sophisticated pens, assemble wooden step stools, and use table saws.


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RECAP: Marlins Get To Kimbrel In Ninth, Beat Braves 3-2
The Marlins were able to score the go-ahead run against Craig Kimbrel in the ninth inning of what was a 2-2 tie game at the time.
RECAP: Marlins Can't Solve Ervin Santana In 6-1 Loss To Braves
The Marlins win streak ended at three games tonight as they ran into Ervin Santana who allowed just one run over 7 1/3 innings with 10 strikeouts.
RECAP: Early Lead Sends Marlins Over Braves In Game Two 6-5
The Marlins were able to win their third consecutive games last night behind an early 6-0 lead over Mike Minor and the Braves.
RECAP: Garrett Jones Delivers Go-Ahead Hit In Extra-Innings Win
Garrett Jones delivered a go-ahead two-run single in the tenth inning of tonight's game to give the Marlins a 3-1 win over the Braves in ten innings.
Braves Release Dan Uggla
The Atlanta Braves have finally released Dan Uggla. The Braves signed Uggla in hopes of having his power help them in the NL East but that hasn't been the case. Since coming to Atlanta, Uggla has struggled mightily and
Video: Upton Brothers Homer In Same Game, Tie MLB Record
The Upton brothers, B.J. and Justin, both homered in last night's game against the Astros, tying an Major League Baseball record.
What is the Biggest Suprise in the American League?
Tuck and O'Neill talks to Ryan Fagan of SportingNews.com about the Biggest Suprises in the American League. Why you should listen: Jerry O'Neill and Mike Tuck talks to MLB writer Ryan Fagan of SportingNews.com about how the Kansas City
Braves' Kimbrel Passes John Smoltz's Save Record
Atlanta Braves closer Craig Kimbrel has made Braves history by passing John Smoltz for the franchise record with 155 saves. Still only 26 years old, Kimbrel has the potential to reach the MLB all-time saves list if he remains
RECAP: Marlins Can't Overcome Early Deficit, Lose To Braves 9-5
The Marlins couldn't come back from an early 5-0 deficit and fall two games out of first place.
RECAP: Giancarlo Stanton Sets New Marlins RBI Record In Loss To Braves
Stanton Sets New Marlins Record In Loss To Braves The Marlins failed to build on their 2-0 lead after the first inning and lost to the Braves 3-2 tonight. The Marlins record now sits at 28-26 and they are


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LDS apostles return to southern South America to visit Mormon members, missionaries and political leaders
President Cartes, who was approaching his first 100 days in office, noted his connection with the church in improving the lives of the Paraguayan people through service and self-reliance.
"Everything is interrelated," he said. "I am working on finding more jobs for my people and you are teaching them how to obtain one."
President Cartes spoke of his admiration for the humanitarian work the church performs in his nation, often done in cooperation with local service organizations. He noted the efforts of the LDS Employment Resource Services in offering workshops about finding job and opening small businesses. The president also offered thanks for the church's involvement in the Instituto Nacional de Cancer where Latter-day Saint doctors have trained local medical professionals and the church has provided medical equipment. This undertaking was initiated following Elder David A. Bednar's visit with the former President of Paraguay a year ago.
Elder Christofferson also presented President Cartes with a "Family Ties" statue that portrays a family reading the scriptures together. The apostle said he was confident the family was reading verses from the Bible or the Book of Mormon.
The Paraguayan leader appropriately placed the family-themed statue in the family room of the president's official residence.
The president spoke of his own appreciation for the scriptures. "I read a Psalm every morning before starting my day," he said. "I have confidence in doing that and in praying to the Lord."
President Cartes then made a simple yet heartfelt request: "Please pray for me." Elder Christofferson responded, "We do and we will."
All who attended the meeting noted a feeling of brotherhood between President Cartes and the visiting church leaders, who left hopeful for strengthened relations and further opportunities to help and serve the Paraguayan people.
While in Paraguay, Elder Christofferson also called on Monsignor Pastor Cuquejo, Catholic Archbishop of Asunción. The two religious leaders met in Monsignor Cuquejo's office in Asunción.
During the 30-minute meeting, the two men spoke of their common, faith-based interests, along with shared humanitarian projects between LDS Humanitarian Services and the Catholic charitable organization "Pastoral Social," including a project to provide wheelchairs to disabled people in Paraguay.
The monsignor also announced, with a smile, that he was a fan of the Mormon Tabernacle Choir.
Elder Christofferson presented the monsignor with a replica statue of the "Christus" Elder González, along with Elder Nicolas L. Di Giovanni, an Area Seventy, and Brother Gustavo Galeano also participated in the visit.
- 24 inspiring quotes from President Boyd K....
- Funeral services for President Boyd K. Packer...
- President Boyd K. Packer, champion of...
- Elder Ballard, other LDS Church leaders...
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- LDS Church donates to Utah Pride... 66
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- President Boyd K. Packer, champion of... 40
- Defending the Faith: Treasures in... 24
- Elder Ballard, other LDS Church leaders... 23
- Ten Commandments decision prompts... 17
- Utah senators seeking support for... 16
- Not everyone has given up on God 8


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2008 GMC Yukon Denali Q&A
2008 GMC Yukon Denali Question: Doors Lock Actuator Keeps Going out
The automatic door locks keep failing. I have had all four actuators on each door replaced several times. What is the problem??? Is there a recall? - gstarnes
7 Answers
Answer 1
Your Denali should still be under warranty ( 3yr-36,000 ) . I would complain to GM about this. This could fall under the lemon law i.e 3 failures in the same system. As to what it could be, who did the diagnosis on your GMC? Maybe they aren't really dialed in to the real problem and are just replacing the parts that break and not the cause? Best of Luck!\ I did find some info on these GMC Yukon Denali Door Lock problems. Apparently there is a known pattern failure with the wiring harness that causes the the door locks, power windows, stereo speakers and courtesy lights to burn out repeatedly. GM knows about it but have not yet 'stepped up' to stand behind their poor design. According to a Lemon Law Attorney, owners of these Yukons DEFINITELY have a Lemon Law case and should pursue it. Best of Luck!! - dandd
Answer 6
i've been throuh this same scenerio,,,,,buy your parts from the gm dealer and not o'riellys or autozone - hippiegearhead
Answer 7
I had this happen to my driver side door summer 2010. I was a few miles over my warranty but the dealership honored it and fixed it anyway. Now my backseat driver side lock has failed! I already know I will have to come out of my pocket to get this one fixed! There is also a problem with the outside door handles becoming separated from the vehicle when you open the door. I called the dealership and they said that yes they had seen several vehicles like mine to have that problem too. But, once again there is no recall listed for this either!...GM needs to do better than what they are doing! - Visitor
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Gunmetal Black Ep 01
episode 14.25 / 5.00 4,111 Views
Lucina's First Day
A look at the first day of Lucina in Super Smash4.23 / 5.00 12,954 Views
BATMAN v SUPERMAN final showdown
SPOILERS!!4.16 / 5.00 11,893 Views
you should have made it longer and worked out the lypsyncing
belive it or not
i say it was funny but i got the WORST sense of humor but it will be 3/10 2/5
good idea
it was a good clip, just needs a bit more humour and maybe a bit longer.
but good idea!
wat the fuck was that?try making it longer with more storyline
Eh, well...I've seen worse. But honestly, it didn't make any sense. It looks like you have tried, but at the same time, it seems like you didn't. It's as though you were trying to make fun of Egoraptor's style but did a very poor job at it. Well, it seems you didn't try at all, but if you did....then try harder next time. (That 3rd star is just me being genorous)


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1996 GMC 2500 Pickup Q&A
1996 GMC 2500 Pickup Question: engine transplant
Engine is dead and the lowest quote was about 5000 to repair. I want to put a cummins from a 96 dodge in and I am wondering what all I will need to replace - bowtechtomkat
Answer 1
I used to do this type of work before it was fun but I had access to professional tools, welder wiring schematics and metal working tools top fabricate anything I needed. This type of work particularly on newer vehicles becomes difficult due to all the electrics/electronics involved. You have to figure out how to mate the engine to the transmission, so you would end up using a Cummins compatible transmission and electronics associated with that, then every single component exhaust ect.... are all custom made parts. It becomes a very expensive proposition. You may also run into problems registering the truck (need to get it re-certified with the DMV (and your insurance company may look at it as a custom/modified car"). I always tell people considering a project like this to sell there truck and buy the truck they want unless it is a labor of love and you realize you are going to get into a real expensive project (I work on race cars, I love that type of work). - patrick mannion
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text:
Rihanna heads to The Box following her debut at London Fashion Week on Feb. 16, 2013. The singer presented a collection for River Island.
She's ready for the summer!
Work it, girl.
Mariah Carey, her boobs and her new beau James Packer, aka the fourth richest man in Australia, took their love to Ibiza, Spain where they gallivanted on a yacht with her kids.
Bad Girl RiRi? More like Braless RiRi.


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All regions
Russia & CIS
East Asia & Australia
Latin America
Middle East & North Africa
South Asia
USA & Canada
The publication period from
The CIA is fighting congressional demands to release a report on its covert program for torturing "war on terror" suspects, even as the spy agency contemplates a reorganization that could give the covert-action side more ways to bend the truth, writes ex-CIA analyst Ray McGovern.
Following disclosure of Brennan's weekend visit to the Ukrainian capital, the White House was evidently caught on the back foot. The Oval Office made the somewhat unconvincing attempt to portray it as a perfunctory meeting between security officials. Well, if it was merely a routine itinerary then why was the fact of the meeting such a closely guarded secret... The timing of Brennan's sojourn in Kiev comes at a crucial juncture. The unelected Western-backed junta in Kiev is threatening a violent crackdown on pro-Russian protesters in the east and south of the country...
Finian CUNNINGHAM | 15.04.2014
Central Intelligence Agency director John O. Brennan has been cooking up a storm in Ukraine and «Brennan Kiev» is the entrée on the menu. Brennan recently paid a secret visit to the Ukrainian capital to discuss with coup leaders their response to the insurgency sweeping eastern Ukraine. It has been reported by various European news agencies that Brennan landed on April 12 in Kiev with a diplomatic passport under a false identity... Brennan, who has been called a «knuckle-dragging thug» by current and retired CIA officials who know him, is not the most welcomed figure in Ukraine if the Kiev authorities actually desire a peaceful outcome with its opponents...
Wayne MADSEN | 15.04.2014
General Petraeus, the head of CIA, resigned admitting to a scandalous extramarital love affair. It made Barack Obama rush to find someone to replace him. As an intelligence veteran, John Brennan was the likely candidate. His nomination for the position popped up for the first time in 2009, but it didn't go through. Back then he realized there was no chance because of his involvement in the CIA "dubious techniques of interrogation", or the use of brutal tortures, to be more exact...
Nil NIKANDROV | 12.02.2013
The steppes of Central Asia give away their secrets only grudgingly. The deserving ones have to convincingly show their capacity for persistence and tenacity – and, of course, sheer audacity. That was how Genghis Khan succeeded in conquering Bukhara...
Melkulangara BHADRAKUMAR
Former career diplomat in the Indian Foreign Service. Devoted much of his 3-decade long career to the Pakistan, Afghanistan and Iran desks in the Ministry of External Affairs and in assignments on the territory of the former Soviet Union. After leaving the diplomatic service, took to writing and contribute to The Asia Times, The Hindu and Deccan Herald. Lives in New Delhi.
Republishing is welcomed with reference to Strategic Culture Foundation on-line journal www.strategic-culture.org.


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Originally Posted by mnwrestlingfan And yet you read an article and decide something is amiss. Some how I don't see guys like gable or robinson squirming because public opinion on a forum has taken a hit or a teleconferance from the NCAA. Defending him? Tou guys want to bury J-Rob with no allegations by the NCAA. Your Info is one article of an over zealous reporter that is expressing their own point of view Damn you are paranoid. Don't be such a homer that you think everyone is out to get you. Show me where I'm trying to bury Robinson.
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about 2 years ago
hi i'm jodie i wish i was born into a different era and i love photography. i heart what ever really not one type off stuff, i also follow back i'm not here for follows though :-) have a lovely day xx
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First-gen Moto G getting Lollipop in India
Now that Lollipop has graced the world with its Material design beauty, manufacturers are updating their devices one by one to the latest version of Android. We've seen Samsung, LG, HTC, and Motorola start updating new devices already. But what about older devices?
Motorola proves itself once again to be ... Read More »


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Select Local Merchants
Forever Young MedSpa DCRead MoreThe cosmetic procedures at Forever Young MedSpa DC in Glenn Dale will enhance your look and confidence. Recapture a healthy and glowing complexion with a facial from this clinic. Keep your skin looking young and fresh with a painless injection, such as Botox. For effective skin care treatments, such as acne treatment, facial peels, microdermabrasion, and spider vein removal, head to Forever Young MedSpa DC. If alternative medical services are more appealing to you, check out this clinic. Take advantage of the various hair removal methods at this establishment and celebrate being bare. Avoid stress build up with a relaxing massage from this clinic. Parking is not available, but you can hop on public transportation as nearby stops such as Mt Vernon Sq/7th St-Convention Center (Green, Yellow) and Shaw Metro (Green, Yellow). Cosmetic surgery is a change toward the life you want.12200 Annapolis RoadGlenn Dale, MD US
Painted FacesRead MoreLittle did Alicia Imani know at 14 years old that her first jobs in salons and spas would inspire a passion for the beauty industry and a future career. Now at Painted Faces, the licensed cosmetologist provides makeup services including wedding-day applications for brides and their attendants and on-set applications for photo shoots. Using cosmetics from MAC, Chanel, and Lancôme, Alicia leads classes where she teaches clients how to apply makeup properly and create looks that work best with their features.9430 Annapolis RoadLanham Seabrook, MD US
Dr Banks Plastic SurgeryRead MoreBoard-certified plastic surgeon Dr. Nia Banks and her team of trained beautifiers offer an eclectic array of appearance-boosting services. Surgical options to fulfill patients' Christmas wishes include tummy tucks, liposuction, and rhinoplasty. For a lighter touch, nonsurgical treatments include injections of Botox—the wrinkle-fading serum that tricks muscles into thinking they are bears that must fall into deep hibernation for months.8116 Good Luck Rd, Ste 215Glenn Dale, MD US
Sonya Michelle Hair SpaRead MoreSonya Fletcher's career started in an unlikely place: her neighbor's scalp. While growing up, Fletcher tended to the hair of neighbors and her own mother, beginning a lifelong love for styling and cosmetology that led her to open Sonya Michelle Hair Spa. Her expertise in braiding, twisting, and weaving keeps her nimble fingers in high demand, but that's not all the salon offers its clients. The service menu also includes moisturizing treatments for curly, kinky, and wavy hair that can be prone to dryness, as well as keratin treatments that imbue locks with smoothness, shine, and the ambition to audition for shampoo commercials. Clients can also come in for color services that can transform looks with vibrant hues.10565 Greenbelt Rd.Lanham, MD US
M and M Tanning Hair and Nail Beauty SalonRead MoreTame your mane at M and M Tanning Hair and Nail Beauty Salon in Lanham, a luxury hair salon that aims to please. No makeover is complete without changing up your hair. This salon provides a number of services including hair cuts and color and highlights so head on over. While this salon in Lanham doesn't accommodate walk-ins, appointments are always quick and easy to schedule. M and M Tanning Hair and Nail Beauty Salon understands some of us live in a cashless society. Guests are invited to pay with any major credit card. Your mane will never look better after a day at M and M Tanning Hair and Nail Beauty Salon, so be sure to swing for either a quick trim or major makeover.9035 Lanham Severn RdLanham, MD US
Seabrook Barber ShopRead MoreTreat yourself to a new 'do at Seabrook Barber Shop in Lanham, a high-quality hair salon. Clients of this salon will experience fashion-forward hairstyle trends to match their personal style. There's no need to make an appointment for your next beauty service because this salon always welcomes walk-ins. A nearby parking lot is readily available for Seabrook Barber Shop's customers. Seabrook Barber Shop's customers can store their bikes safely at the rack around the corner. Whether you're coming in for just the usual cut or a special styling, Seabrook Barber Shop will meet your needs with nothing short of excellence.9424 Lanham Severn RdLanham, MD US


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"Selling Upstate Catskill Mountain Properties Since 1889"
D. Todd Ogden, Principal Broker233 Delaware StreetWalton NY 13856607-865-7000
Welcome to our paradise in the foothills of the Catskill Mountains and the Delaware River Valley. If you are looking to purchase real estate in this beautiful, rural, Upstate New York area, you need to look no further. With our team of professional and experienced real estate salespeople, along with a great inventory of Upstate NY Catskill Mountain properties, we are ready to help you obtain your goal of purchasing land, a home, cabin or other seasonal getaway. If you are looking for investment properties, we also have commercial and multi-family listings. Give us a call today at 607-865-7000 to set up an appointment to view any of our Catskill Mountain properties!
Nice package with 97+ acres!
Beautiful home with mother/daughter apartment!
31+ acres with nice views and road frontage!
Asking: $150,000Listing #: 916853 bdrms/1.5 bths14+ Acres
Asking: $130,000Listing #: 9474640.54 Acres
Reduced to: $240,000Listing #: 96431Lrg Home w/5 bdrms, 2.5 bthsLrg Renovated Barn, 16+AcsMany Pluses!
Asking: $79,900Listing #: 994683 bdrms/1 bth.25 Acre
Asking: $90,000Listing #: 993453 bdrms, 1.5 bths.93 Acre
Asking: $119,000Listing #: 973914 bdrms, 1.5 bths.25
Asking: $149,000Listing #: 944293 bdrms/1 bthBeautiful Village Home!
Asking: $124,900Listing #: 974123 bdrms/1.5 bthsImmaculate, Like New!
Asking: $215,000Listing #: 9702568 acs With Cabin& Many Extras
[Home] [Listings] [About Us] [Agents] [Our Area] [Local Information] [Directions] [Contact] [Disclaimer]


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Libby Molyneaux
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The Abercrombie Hotel is located just near Broadway on your way into Sydney's CBD.
View the venue listing
Invite friends
Ticket + booking fee /
$40.00General admission
- Event admin /
- kali
- Update this event
Line-up /
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- Picnic
Ivan Smagghe, Pachanga Boys, Kali
Four days off work means big celebrations, and we've arranged the biggest of all. Picnic are proud to present a night at The Abercrombie Hotel with IVAN SMAGGHE AND PACHANGA BOYS. Seriously. Dunno if the Easter Bunny works the same way that Santa does, but you've all been good boys and girls and we think you've earned it.
It may be more time efficient to talk about the things that Ivan Smagghe hasn't done than the things that he has. As Black Strobe he played a crucial role in the rise of (tasteful) electroclash. He has released a whole stack of incredible mix albums, including 2004's seminal Death Disco as well as contributions to the Fabric, Bugged Out! and Live At Robert Johnson series. As head of A&R he led Tigersushi sub-label Kill The DJ to become a hugely respected imprint worldwide. He's one half of It's A Fine Line (with Tim Paris), he produces with German production powerhouse Roman Flugel as RMVN, and he can be found spinning back to back with the legendary Andrew Weatherall on a semi-regular basis ever since the pair ran Wrong Meeting at London's T Bar until 2008.
There's plenty more to add to the resume, but you get the picture. Smagghe's remarkable musical intuition has made him one of the world's most respected and sought after acts, both in the studio and behind the decks. With one of the deepest record bags in the business, his sound is never the same from one moment to the next, yet it's always distinctly Smagghe.
The purveyors of love, joy and the power of Pachanga: when Superpitcher and Rebolledo joined forces back in 2010 the world became a more partyful place for everybody. Their Hippie Dance imprint, a sub of Cologne powerhouse label Kompakt, was born out of the perfect partnership between a German master of shimmering techno and grooving house and a Mexican oddball whose releases on Matias Aguayo's Còmeme celebrate a humorous, fun-loving approach to dance music. Together, the pair have put out three unbelievable 12-inches, including 2011's 15 minute massive euphoric burning odyssey 'Time', and their recent debut LP 'We Are Really Sorry' which was a huge favourite of 2012 for dancers and DJs around the globe. The "Hippie Dance Atelier Super Limited Collectors Edition" of the album included a 36 page psychedelic coloring book with special crayon pack, a postcard to send the one you love and an organic cotton and Alpaca knitted tortilla chip broche - yeah, they're pretty fun dudes. Peace, Love, Power and Pachanga!
It'll be Ivan's first visit in 7 years and the debut of the Pachanga Boys in Aus, so this is a very special occasion!
Doors 10pm
KALI on warm up.
$40 Presale
Resident Advisor: http://www.residentadvisor.net/event.aspx?452935
Pulse Radio: http://pulseradio.net/events/view/1047
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1804 10C 14 Stars on Reverse -- Stained -- NGC Details. AU. JR-2, R.5....
2011 August Chicago Signature US Coin & Platinum Night Auction #1158
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Marriott - Chicago O Hare
8535 W. Higgins Road
Chicago, IL 60631
|Printable auction results for all items in the 2011 August Chicago Signature US Coin & Platinum Night Auction.
1804 JR-2 Dime, 14 Stars Reverse1804 10C 14 Stars on Reverse -- Stained -- NGC Details. AU. JR-2, R.5. The 14 Stars reverse and the 13 Stars reverse were both used for 1804 dimes and quarter eagles. Both varieties of dime and the 13 Stars quarter eagle are rarities, and even the 14 Stars quarter eagle is elusive, regardless of grade. This example has modest surface roughness with unusual brown and gray coloration that suggests it may have once been buried. However, it is extremely sharp for an 1804 dime, and would rank high in the Condition Census if the surfaces were smooth and original. Here is an extremely important opportunity for the early dime collector, as few have an 1804 dime in any grade.
AU Details, Extraordinarily Sharp
AU Details, Extraordinarily Sharp
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Take a cakewalk on Halloween in this adorable Strawberry Shortcake Deluxe girls costume. You'll be the apple of everyone's eye in this darling, 100% polyester dress, complete with character hat and tights.
Collect plenty of treats on Halloween when you wear the officially licensed Lalaloopsy Crumbs Sugar Cookie child costume. Be careful, the 100% polyester dress is cute enough to eat!
Feeling hot, hot, hot! Ultra cute for any photo, this chili pepper baby bunting is a treat of an infant Halloween costume. And as long as you keep your little one in this bunting, he won't be chili through any of the festivities. Pair with the matching adult costume (sold separately) for family fun!


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The Journal Sentinel's team of Packers beat writers provide the latest news, notes and analysis
Lions hand over control of NFC North to Packers, Bears
Green Bay - The Packers created their own breaks Sunday against the Dallas Cowboys and then the Detroit Lions delivered them another one Monday night.
As a result of the Lions' 18-16 loss to the Baltimore Ravens at Ford Field, the Packers control whether they win the NFC North.
If the Packers beat Pittsburgh at Lambeau Field Sunday and the Chicago Bears at Soldier Field Dec. 29, they would win the division and host a first-round playoff game.
Ravens kicker Justin Tucker hit a 61-yard field goal with 38 seconds left to provide the winning points Monday night. The Lions lost for the third time in four games, their only victory during that span a 40-10 drubbing of the Packers on Thanksgiving Day.
Here are the standings in the NFC North heading into Week 16:
- Chicago (8-6)
- Green Bay (7-6-1)
- Detroit (7-7)
- Minnesota (4-9-1)
Here are the remaining games on each team's schedule:
- Chicago: at Philadelphia (8-6), Green Bay (7-6-1)
- Green Bay: Pittsburgh (6-8), at Chicago (8-6)
- Detroit: New York Giants (5-9), at Minnesota (4-9-1)
- Minnesota: at Cincinnati (9-5), Detroit (7-7)
Regardless of what Chicago does this weekend, the Packers have to beat the Bears to win the division. If Chicago lost to Philadelphia and Green Bay beat Pittsburgh, the Bears would be 8-7 and the Packers 8-6-1.
If Chicago loses to Philadelphia and beats Green Bay, Detroit could win the division by winning its final two games. The Lions beat the Bears twice and have a head-to-head tiebreaker.
Now that the Packers control their own destiny it will be interesting to see if it changes the way they view the risk-reward factor with QB Aaron Rodgers. It will be seven weeks on Sunday since he broke his left collarbone and with the playoffs definitely possible, the reward part of the equation jumps precipitously.
Rodgers is expected to be evaluated on Wednesday and could be cleared to play then. Or he could go through the same thing as last week when he practiced Wednesday and Thursday on a part-time basis and a decision on his status was made on Friday.
The Packers have won two straight under backup Matt Flynn and are 2-1 in games that he has started.
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Sunday Meetup
- Panera Bread
- 765 Elmwood Avenue, Buffalo, NY (map)
Hosted by: Bojidar K. (Organizer)
This Meetup repeats on the 1st Sunday of every month
Sunday Meetup 1 going Sun Aug 2 2:00 PM Sunday Meetup 1 going Sun Sep 6 2:00 PM Sunday Meetup 1 going Sun Oct 4 2:00 PM
Sunday Meetup #2
- Panera Bread
- 5311 Main Street #100, Williamsville, NY (map)
Hosted by: Bojidar K. (Organizer)
This Meetup repeats on the 3rd Sunday of every month
Sunday Meetup #2 1 going Sun Aug 16 2:00 PM Sunday Meetup #2 1 going Sun Sep 20 2:00 PM Sunday Meetup #2 1 going Sun Oct 18 2:00 PM
Recent Meetups
May 3 · 2:00 PMSunday MeetupHey everyone,It seems like its been a while since our last LW meetup. I recently read this post on LW and thought it would be great thing to actually try out. Let... Learn more
March 16 · 7:00 PMMonday MeetupHey guys,Lets discuss science reporting. Scott Alexander provides a wonderful critique of recent paper that has been widely reported upon claiming to have discovered the... Learn more
February 22 · 2:00 PMGaming MeetupHey all,We talked about some cool ideas about developing games that encourage rational problem solving. Let's try out those ideas and see how what works. I'm excited to... Learn more
February 1 · 2:00 PMSunday MeetupThis week we're going to discuss rational characters in fiction and media. We will also discuss ways of making games that teach thinking skills and rationality.
January 19 · 7:00 PMMonday MeetupHey guys, I'm interested in talking about "the quantified self" movement. Simply put, this is a movement to use technology to gather data about yourself (eating behavior... Learn more
- See all past Meetups


text:
Often one wants to print out additional information if an
assert fails. A way to do that is this:
assert(vec.size() > i ||
!(std::cerr << "False: " << vec.size() << ">" << i))
This way the actual sizes are printed when the
assert fails. But it's ugly, and also it's easy to forget the
! , which will make the assertion condition true and the program will just continue.
What do people use instead to print additional information on assertion failure, like above?


text:
5 things you should do to keep your tyres in check
The hot summer months do take their tollJuly 5, 2015 12:00
Register for our free newsletter
Abu Dhabi's Dana Gas hits 9-wk high after wins Kurdistan case
Saudi Telecom Co to pay Q2 dividend of 1 riyals/share
UAE non-oil business growth slows to 22-month low in June
MIDEAST STOCKS-Gulf likely to be subdued by oil price drop, Greece
Abu Dhabi's TAQA drops 5.4 pct after saying no merger talks
Qatar's Doha Bank raises 2 bln riyal Tier 1 capital-boosting bond
Dubai's Drake & Scull increases GCC ownership limit to 100 pct
Abu Dhabi's TAQA says not holding merger talks
Gold languishes below $1,170 ahead of U.S. jobs data
Kuwait parliament approves budget with $27 billion deficit
The Dubai index rose by…
August 23, 2009 2:56 by kippreport
The Dubai Financial Market General Index climbed 2.5 percent on August 23, its most since August 18, and Abu Dhabi's index added 1 percent, thanks to increasing oil prices, reports Bloomberg. Oil prices went up by 1.9 percent to $73.89 a barrel after existing- home sales in the U.S. increased by 7 percent in July.
The shares of property developer Emaar increased 4.3 percent to AED3.15, its highest since August 16.
1 Comment
Why this market is always driven by sentiments rather thank the real performance of listed companies?
No Matuirty
Keep walking
August 23 2009
Equity funds in GCC up 30 percent in Q2
August 23 2009


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Image Unavailable
|Item Weight
|399 g
|Product Dimensions
|11.6 x 6.9 x 4.2 cm
|Item model number
|Best Sellers Rank
|24,607 in Computers (See top 100)
|Shipping Weight
|399 g
|Date First Available
|2 Oct. 2009
The Razer Naga is the ultimate MMO Gaming mouse that shifts the balance between keyboard and mouse by putting an unprecedented number of in-game commands in one place. A multi-button thumb grid and Razer's MMO game interface add-on combine to place every command you need in the palm of your hand. An ergonomic form shaped to maximize ease of use lets you game in comfort for hours on end. With the Razer Naga, you will Get Imba.
Program up to thousands of different in-game commands.
Game for days with the Razer Naga's ergonomic design, optimized for easy access to every button.
Organize your skills and eliminate visual clutter with the Razer Naga's in-game custom interface AddOns (available for World of WarcraftTM and Warhammer Online: Age of ReckoningTM, and more).
good mouse but it does not last. It double clicks, i have tried fixing it with web tutorials and still double clicking. AVOIDPublished 7 days ago by J. Barnor
I don't know how I ever managed to play games without this fantastic mouse!!Published 28 days ago by Optymyst
Great mouse, only downside is I got a faulty one that I have to plug into my computer every time I reboot, But saying that had it years now and still working.Published 1 month ago by Richard R.
Had this years now - I would not do without it. If mine breaks I will be buying another exactly the same to replace it!Published 2 months ago by Daniel Westwater
Excellent feel and super accurate for any game.I love it..A must have for any gamer.Bought it a good while ago and even with all the use, there are no issues with this.Published 3 months ago by Racing Junkie
The best & also last mouse I will ever own. This is an absolute beauty to use, it feels great in your hand as if it were specifically moulded for your own hand. Read morePublished 5 months ago by Khalid Junaid
Had this for years and couldn't uses anything less now.
The only issue I'm having now is when I click the left button it's double clicking. Read more


text:
List all words starting with disfurnishes
Only the word disfurnishes was found, nothing longer.
Some random words: eohippus wirable no pias juba ahimsa via
This is not a dictionary, it's a word game wordfinder.
- Help and FAQ - Examples - Home
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text:
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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
51 year old woman | New Albany, IN, USA | Seeking men 38-55 within 25 miles
Active within 24 hours
Classy, Sassy Single Mom
Strong Christian mom of four, my oldest son is just starting a new job working for the University of Illinois after a two year long internship working for the University of Minnesota and my oldest daughter at Ball State. The two at home are teenagers with their own social life. This leaves me with time to have a social life of my own. I have been divorced for thirteen years now (not of my own choosing). I have been in a couple long term relationships that ended up just not being the right match. I am self - employed and stay very busy with everything that is asked of me. However I can always make time for some fun time and getting to know that special someone. I am looking for an attractive, confident man, a man who likes the outdoors. Emotionally stable, positive, and self-sufficient. Someone who loves the family life and all that comes with that. Someone who knows how to treat a lady like one and good manners is a must. Not looking for a father for my kids but someone who will be a good role model for them. I am also not someone who will be the pursuer. Tend to be a little old school with that. The bar scene is really not me would rather go out to the theater, dinner, the park or a sporting event. I am looking for my best friend someone who would like to talk by phone when we cannot be together. Someone who wants to share their life with me and I in turn share mine with him. For those who are not willing to share a picture or those who want to show their pets and vacation pictures but not themselves I am really not interested in chatting. While we all know it is not all about looks the truth is it has to start with an attraction. I do my best to live a healthy life style and take care of myself and exercise and I would like the same in a partner. Equally important is your teeth. A matter of fact teeth are more important than the perfect body. I would also like to add I do not need or want a pen pal. So for those of you who just want to exchange emails and never ask someone out please do not waste my time or yours. I will just kindly stop responding.
Camping , Coffee and conversation , Business networking , Cooking , Dining out , Gardening/Landscaping , Hobbies and crafts , Movies/Videos , Music and concerts , Exploring new areas , Performing arts , Playing cards , Playing sports , Religion/Spiritual , Travel/Sightseeing , Volunteering , Watching sports
Bowling, Dancing, Golf, Running, Skiing, Swimming, Tennis / Racquet sports, Walking / Hiking
I exercise 3-4 times per week.
I have Fish
I love to go horseback riding. However I have not been in a long time.
I love the beach or anywhere warm. Really anywhere in the great outdoors. I have lived all over the US and also in Australia. So I would have to say Australia was my favorite.
Ball State University, Muncie, IN
I love to run for my mental health. Spending fun time with my kids. Picnics in the park, long walks, sharing a cappicinno, and great back rubs. I also enjoy going to the lake and being on the boat.
I like running, playing tennis, water sports and camping. I love a dinner for two by the fireplace. Cookouts with friends and family. Really I am happy being around lots of friends and or family and also being alone at home with that special someone.
I do not have alot of time to just sit down and read. I read my Bible and look at facebook friends at night to unwind. I have read Your Best Life Now. Uncommon, Lies women believe, Bringing up girls & boys, Five love languages. His needs Her needs.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'4" (162cms)
|5'6" (167cms) to 6'3" (190cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned, A few extra pounds
|Black, Blue, Brown, Grey, Green, Hazel
|Dark brown
|Black, Light brown, Dark brown, Blonde, Salt and pepper, Silver, Dark blonde, Grey, Platinum, Bald
|No Way
|No Way
|Never, Social Drinker, Moderately
|Self-Employed / Entrepreneur
|No preference
|I'll tell you later
|No preference
|Never Married, Widow / Widower, Divorced
|Have kids:
|Yes, and they live at home (2)
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|No, but it's OK if my partner has kids
|No, but it's OK if my partner has kids
|White / Caucasian
|White / Caucasian
|Christian / Other
|Christian / Catholic, Christian / LDS, Christian / Protestant, Christian / Other
I attend Northside Christian Church in New Albany
|Bachelors degree
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


text:
The Rise & Fall of ECW: Extreme Championship Wrestling
Simon and Schuster, May 22, 2007 - Sports & Recreation - 272 pages
Independent wrestling promotions were once the norm all across the country. However, with the rise of World Wrestling Entertainment and the creation of World Championship Wrestling -- out of three Southern promotions -- the possibility of an independent succeeding grew fainter and fainter. As the nineties began, independents were looking for creative ways to survive. In the East, several banded together to share cost and talent; they were known as Eastern Championship Wrestling. Based out of a warehouse in Philadelphia that stored parade floats and hosted bingo, this promotion seemed doomed to be just one more ninety-day wonder. When they hired a brash New Yorker, Paul Heyman, he warned Eastern Championship Wrestling that the job was just temporary. He would come in, shake up a lot of the wrestlers, and then leave. But what Heyman did redefined professional wrestling in the nineties. What he created was a company that dared to push the boundaries of sports entertainment. What he created became Extreme Championship Wrestling.
As the person responsible for booking -- who was going to wrestle and who was going to win -- Heyman dared to break with tradition. Rather than relying on local talent and down-and-out veterans to draw in crowds, he created new characters and story lines that would appeal to the core wrestling fans: eighteen- to twenty-four- year-old men. Paul also realized that to persuade them to come, you had to get their interest and keep it. You had to offer the fans more than just the match. ECW became known for the interview, the shoot. Heyman got to know each wrestler's style, and in their interviews he would encourage them to speak from their hearts. When it came to the matches, ECW broke even farther from the mainstream. Tables, ladders, chairs, barbed wire, and even frying pans were used with abandon. Wrestlers not wanting to be topped put their bodies on the line, taking ever greater risks, daring to jump, leap, and fall from places never tried before. ECW matches became the stuff of legend.
Word spread as savvy wrestling fans began talking about the promotion and exchanging tapes. To keep the buzz building, wrestlers used the age-old trick of taunting the fans, and ECW fans responded in kind. By including the fans in the shows, ECW attracted a rabid, cult-like following that is still going strong today.
For nearly a decade, ECW redefined professional wrestling with a reckless, brutal, death-defying, and often bloody style that became synonymous with "hardcore." Through extensive interviews with former ECW talent and management -- Paul Heyman, Mick Foley, Tazz, Tommy Dreamer, Rob Van Dam, and many more -- The Rise & Fall of ECW reveals what made this upstart company from Philadelphia great -- and what ultimately led to its demise.
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Review: The Rise & Fall of ECW: Extreme Championship WrestlingUser Review - Frank Gurrieri - Goodreads
Being a huge pro wrestling fan, ECW was something I got into later after they already closed. I went to a show when I was younger on Staten Island but I didn't know anyone back then. This book had a ... Read full review
Review: The Rise & Fall of ECW: Extreme Championship WrestlingUser Review - Goodreads
One of my least favorite wrestling books that I've read. It was essentially a work, just giving results of ecw shows in chronological order. No real "behind the scenes" dirt or anything interesting. Read full review
Selected pages
Section 2
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Section 5
Section 6
Section 7
Section 8
Section 14
Section 15
Section 16
Section 17
Section 18
Section 19
Section 20
Section 21
Section 9
Section 10
Section 11
Section 12
Section 13
Section 22
Section 23
Section 24
Common terms and phrases
babyface Bam Bam beat belt Beulah Bubba Buffone Cactus Jack called chair Champion chanting Chris Benoit Cold Scorpio crowd D-Von Dean Malenko defeated Dudley Boyz Dudleyz Eastern Championship Wrestling ECW Arena ECW Heavyweight ECW Tag Team Eric Bischoff feud fuck gimmick going happen hardcore Heavyweight Championship heel Heyman explains Heyman recalls Heyman says Japan Jerry Lawler Joey Styles knew locker room look loved match Meanie Mick Foley microphone Mike Mikey Whipwreck Mysterio named never night Nova Paul Heyman Pay-Per-View Philadelphia Pitbulls professional wrestling promotion Psicosis Public Enemy Raven remember ring Rob Van Dam Sabu Sandman Shane Douglas Singapore cane Spike star started Steve Austin Stevie Richards tag team title talent talk Tazz television Terry Funk thing Tod Gordon told Tommy Dreamer took Vince McMahon walked World wrestlers Wrestling Federation


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Town Make Stearman Enquiry
Wednesday, 27th Jul 2011 22:58
Town have made an enquiry to Saturday's friendly opponents Wolves regarding their versatile defender Richard Stearman. The 23-year-old's opportunities at Molineux look likely to be limited during the season ahead with manager Mick McCarthy having signed Roger Johnson from Birmingham for £4 million earlier this summer.
Wolverhampton-born Stearman started his career with Leicester, making his debut for the Foxes in 2004.
Four years later, having been a regular in the Leicester side for the previous three seasons, he joined his hometown club for an undisclosed fee.
A member of the 2008/09 Wolves Championship-winning side, £1 million-rated Stearman primarily plays at centre-half but also at right-back, both areas where the Blues currently need cover.
Last season, 6ft 3in tall Stearman made 32 starts and four sub appearances, scoring one goal, largely covering for injured skipper Jody Craddock, who has just signed a new deal at Molineux.
An England U17, U18, U19 and U21 international, Stearman, who is contracted to Wolves until 2014, was linked with a switch of allegiance to the Republic of Ireland, the country of a grandparent's birth, earlier in the year.
Get two free £10 bets on Brentford v Ipswich Town (or other matches) by opening a new account at William Hill. Place an initial bet of a minimum of £10 and William Hill will give you two £10 bets. You must enter the promotional code "F20" when signing up as a new customer.
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So, How Have They Done? by GeorgeITFC24
It's been roughly 12 months now since last year's summer signings have been at the club. There have been some great moments from our new players, and equally a few lows! But how well have they done in their debut seasons?
Who's Next Between the Sticks (Or Be Careful What You Wish For)? by MedwayTractor
Having read so many recent comments about our perceived goalkeeping problem, I have put my own thoughts together on this subject.
Norwich Promotion: A Good Thing Or A Bad Thing? by calumberjack
Now I know what you're thinking but hear me out. Celebrating the promotion of our greatest rivals seems spineless and cowardly, especially as they were the ones that dumped us out of the play-offs, but as I sat watching the second spectacular goal scored by that **** Nathan Redmond, I couldn't help but ask myself whether this was really such a bad thing.
Gerken Vs Bialkowski by GeorgeITFC24
Looking back on the season our two goalkeepers shared the starting spot this campaign. Dean Gerken spent almost every match of the 2013/14 in the Town goal as the undisputed number one.
Goals From Midfield by rickw
Looking back on this season and most of us would admit Ipswich reached or exceeded our expectations, but after coming so close to success we are now all hungry for more - and for Ipswich to take that next step and challenge for automatic promotion.
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10 Finalists Announced for 2014 USA Softball Collegiate Player of the Year
OKLAHOMA CITY, Okla. — The Amateur Softball Association (ASA) of America and USA Softball have announced the Top 10 Finalists for the 2014 USA Softball Collegiate Player of the Year award, which will be announced on Tuesday, May 27 just prior to the start of the 2014 NCAA Women's College World Series (WCWS) in Oklahoma City.
This award, which is considered the most prestigious honor in Division I women's softball, is designed to recognize outstanding athletic achievement by female collegiate softball players across the country.
Click here to see the Top 10 finalists for USA Softball Collegiate Player of the Year
Now in its 13th year, previous recipients of the USA Softball Collegiate Player of the Year award are UCLA catcher Stacey Nuveman (2002), Texas pitcher Cat Osterman (2003, 2005 and 2006), Florida State pitcher Jessica Van der Linden (2004), Tennessee pitcher Monica Abbott (2007), Virginia Tech pitcher Angela Tincher (2008), Washington pitcher Danielle Lawrie (2009 and 2010), Stanford shortstop Ashley Hansen (2011) and Oklahoma pitcher Keilani Ricketts (2012 and 2013).
This year's finalists are comprised of four seniors, three juniors, and three sophomores. The student-athletes selected represent seven NCAA Division I universities and five athletic conferences. Alabama, Florida State and Oregon lead the way among universities with two athlete representatives each.
The top three finalists selected from this list will be announced May 21, with the winner of the 2014 USA Softball Collegiate Player of the Year Award revealed on May 27.
The USA Softball Collegiate Player of the Year award is voted on by coaching representatives from 11 Division I Conferences in the 15 ASA Regions as well as members of the media who consistently cover Division I Softball across the country, and previous Player of the Year recipients.
In addition to bestowing the USA Softball Collegiate Player of the Year award, ASA/USA Softball is now in its 12th season of presenting the ESPN.com/USA Softball Collegiate Top 25 Poll and the USA Softball Collegiate Player of the Week, which are announced Tuesdays during the regular season.
** release courtesy of USA Softball


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Represents the kind of day I had
vaporizing my brain with my son's alien gun.
please dont vaporize your brain.
no brain left to vaporize.
Haha, classic!
Yeah try having 4 kids, they can do that to you too. Great Pic!
I wish I could blame it on the kids. kids would never cause this kind of crap. adults are the problem. we suck.
True we really do sometimes.
but hey, what a way for your brain to go. vaporized. beats drugs. well done.
haha, thanks Jeffrey, always looking on the positive.
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Tel: (714)758-1500
Private, for profit
Maric College is an institution of higher learning dedicated to providing quality programs that integrate the curriculum with professional skill development, empowering students to achieve their lifelong personal and professional goals.
School Highlights:
Minority enrollment is 100% of the student body (majority American and Asian), which is less than the state average of 63%.
School Overview
|Maric College-Anaheim
|Community College Avg.
|Institution Level
|At least 2 yrs but < 4 yrs
|At least 2 but less than 4 years
|Institution Control
|Private, for profit
|Diversity ScoreThe chance that two students selected at random would be members of a different ethnic group. Scored from 0 to 1, a diversity score closer to 1 indicates a more diverse student body.
School Notes:
Maric College is part of a network of over 75 schools nationwide offering quality career-focused education. The tradition of excellence began in 1987 when Educational Medical, Inc. purchased three well-respected Maric Colleges - a group of career colleges offering training in the allied health fields - in Southern California. In 1998, Educational Medical, Inc. changed its name to Quest Education Corporation to better reflect the diversity of programs within the 30 schools operating in 11 states. In August of 2000, Quest Education Corporation was purchased by Kaplan, Inc., a division of the Washington Post. Quest Education Corporation changed its name to Kaplan Higher Education Corporation in 2002. Maric College provides the best in career education. The college offer hands-on career education for today's fastest-growing careers in the Arts & Design, Business, Healthcare and Legal fields. There are different program options at each of our locations across California. Our campuses are located at Modesto, Sacramento, Bakersfield, Stockton, Fresno, Anaheim, Palm Springs, North County, Riverside, San Diego, Carson, Los Angeles, North Hollywood, Panorama City and Pomona. Programs Offered at the Anaheim campus includes Legal Administrative Assistant, Medical Assisting and Paralegal/Legal Assistant.
Nearby Schools:
- College Location Mi. Students
Orange South Coast College
2011 W. Chapman Avenue
Orange, CA 92868
(714)867-5009 2.6 Mi | 363 students
Garden Grove Concorde Career College-Garden Grove
12951 Euclid Street Suite 101
Garden Grove, CA 92840
(714)703-1900 3.3 Mi | 868 students
Orange Career Networks Institute
702 W Town and Country Rd
Orange, CA 92868
(714)437-9697 3.7 Mi | 570 students
Santa Ana Santa Ana College
1530 W. 17th Street
Santa Ana, CA 92706
(714)564-6000 4 Mi | 16596 students
Fullerton Fullerton College
321 E Chapman Avenue
Fullerton, CA 92832
(714)992-7033 4.2 Mi | 23989 students
Recent Articles
Updated June 19, 2015
Community colleges have responded to the needs of working adults with online options.
Leading the country in slashing public education spending, Arizona voted to defund higher education, including Pima and Maricopa Community College Districts, leaving many Arizona college students wondering what this new state legislation means for the future of their education.
Not all community college students spend their winter and summer break on vacation. Some utilize that time to take a few extra classes and earn credits that can help them graduate early. Other students test out of courses and receive credit for work experiences in order to get ahead. In this article, learn about the various methods you can use to pursue extra college credits.


text: The "Ode To Herbert" From Family Guy [Video] By Monster December 2, 2011 9:15 PM Share on Facebook Share on Twitter Without a doubt "Family Guy" is one of my favorite shows and one of the characters that makes me laugh the most is Herbert. Check out this video that the guys from Adult Swim have made in his honor. Filed Under: adult swim, family guy, herbert, Morning Show Category: Morning Show, Morning Show Video, Videos Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of KLAQ Recommended For You Best of the Web