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INTRODUCTIONMany genes play important functions for the normal cell cycle or program. Whenever there is any problem in normal gene expression or when these genes are mutated all the mechanisms of cell proliferation, differentiation of cells and apoptosis which leads to the formation of cancerous cells. AZD6244 or selumetinib is one of the lethal drugs which cause mutations in these genes for example RAF, RAS and BRAF genes. This is a kinase inhibitor, and inhibits activity of MEK. MECHANISM OF ACTIONAZD6244 is a second generation inhibitor and selective for MAPK/ERK kinase 1/2. It does not compete with ATP, substrate for these kinases so it is non-competitive inhibitor. The genes of MAPK/ERK kinase 1/2 are located downstream to BRAF and RAS and they are efficient activator of ERK1/2 [2]. AZD6244 is under clinical evaluation phase II trials like angiogenesis inhibitors. The research on efficacy of this inhibitor has been done in good number of xenograft models of tumors for example pancreatic (BxPC3) and colorectal (HT-29) tumor models [2]. It is reported that 14nmol/L concentration of this drug has ability to inhibit the activity of MEK1. During in vivo studies, a chronic dose of AZD6244 at 25mg/kg resulted in inhibition of growth in Calu6, colo-205 and SW-620 xenografts. On the other hand acute dose also inhibit the phosphorylation of ERK1/2. However these results were variable for all these xenograft models [2]. However this is a selective inhibitor as normal fibroblast cells are not affected by it. And it was able to suppress the growth of tumor in case of mouse xenografts [1].EFFECT ON BRAFThose signaling pathways which are mediated by or through RAF/RAS/MEK/MAP kinases are having important roles in normal cell growth because the growth is influenced by different signals of these pathways. In case of cencer cell lines a large number of mutations are found in RAF and RAS genes. Only a single mutation in the BRAF gene kinase domain with single single substitution (V599E) is the cause of abnormal growth of myeloma cells [4]. Due to these mutations NIH3T3 cells are transformed because of high kinase activity. Mutated forms of BRAF gene enhance the sensitivity of cells to inhibition of MEK. Hence those agents which target the mutations in BRAF genes are able to control the cancerous growth in different cell lines [3]. It is also studied that these BRAF mutations are connected with the low expression of protein cyclin D1 thereby arresting cell cycle at G1 phase. These experimental researchs clearly showed the concept of tumor growth suppression due to inhibition of MEK1/2. However these mutations of MEK1/2 can also partially inhibit the tumor induction due to RAS mutations [3].EFFECT ON ERK1/2AZD6244 has ability to inhibit phosphorylation due epidermal growth factor (EGF) of ERK1/2 in case of A431 cell lines, resulting in the growth suppression [4]. This compound had no effect on normal cell lines while cells having BRAF or RAS mutations were strongly affected by this inhibitor. These findings suggested the action of this inhibitor because there was not any other cytotoxic agent activity. This inhibitor was much more active in case of SW-620 xenografts which are human based xenografts in nude mice. Research has been done and it is reported that in case of varyingsly originated cancer or tumor cell lines; there is no connection between kianse activity of mutated or phosphorylated protein (MEK/BRAF, RAS and PI3K) and MEK inhibitory effect [5].CONCLUSIONAZD6244 is a strong inhibitor of MEK1/2. This inhibitor is undergoing clinical trials and proved to be effective against cancer cell lines. The downstream genes of different kinases are inhibited by this agent. However this is not very effective in some of the cancer cell lines. Hence this agent can be used in combination with other anti cancer agents like Paclitaxel andTaxol.REFERENCES1. Yeh TC, Marsh V, et al. Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor. Clin Cancer Res 2007 March 1;13; 1576.2. Davies BR, Logie A, et al. AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal- regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. Mol Cancer Ther 2007 August 6; 2209.3. Solit DB, Garraway LA, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006 Jan 19; 439(7074):358-62.4. Davies H, Bignell GR, et al. Mutations of the BRAF gene in human cancer. Nature 2002 Jun 27; 417(6892):949-54.5. Dry JR, Pavey S, et al. Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244). Cancer Res 2010 Mar 15; 70(6):2264-73.Related Posts:BIRB 796 : ENHANCES THE EFFECT OF BORTEZOMIBBELINOSTAT (PXD101) - APOPTOSIS INDUCER OF CANCER CELLSRelated to AZD6244 (SELUMETINIB) - A MUTAGEN FOR RAF GENES AZD6244 (SELUMETINIB) - CHECKS MUTATIONS IN RAF GENES INTRODUCTION Certain vital genes are responsible for the maintenance of the normal cell program. When mutations in these genes get accumulated it disturbs cell proliferation, ... AZD6244 - REGULATES THE DOWNSTREAM KINASES TO BRAF AND RAS INTRODUCTION Most of the human tumors are related with the up regulation of the MAPK pathway. This pathway gets activated as a response to various ... Selumetinib (AZD6244) - A Unique Molecule with Versatile Actions and Anti-Tumor Properties INTRODUCTION: RAS-RAF-MEK-ERK pathway is one of the major deregulated and proliferative pathways which play a significant role in the pathogenesis of various malignancies. Approximately 30% ...
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Finale discussion thread (spoilerifictitle insided) *SPOILERS WITHIN*
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April 23 2013, 02:29 AM
Allyn Gibson
Vice Admiral
Location: South Pennsyltucky
Re: Finale discussion thread (spoilerifictitle insided) *SPOILERS WITH
Professor Zoom wrote:
I would love it if she was a TARDIS. (Of course, there would be endless fanboy jokes about getting inside, the inside being bigger, blah blah blah)
But, a humanoid as Tardis would be so weird on TV (didn't they do that on the radio stories?) that it would be fantastic.
Novels. Compassion was a human that was transformed into a TARDIS, and the eighth Doctor and Fitz traveled in her during a period when the TARDIS was destroyed.
Romana's insane third regeneration attempted to capture Compassion so she could give birth to a new race of humanoid TARDISes.
In the future of the War, the Time Lords bred humanoid War TARDISes to carry them into battle against the Enemy. Homonculete, a Time Lord from that era whom the eighth Doctor met in
Alien Bodies
, traveled in a humanoid TARDIS named Marie. I think she was a Type-104 or somesuch.
"When David Marcus cited the great thinkers of history -- "Newton, Einstein, Surak" -- Newt Gingrich did not make his list." --
24 January 2012
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Latest | Highest rated
Capitalism's End Game [View instapost]
How many people complaint agains Monsanto for example and they would be surprised that they hold them in Their 401k through the index ETFs or mutual funds.Jun 19, 2013. 11:40 AM | 1 Like |Link to Comment
Capitalism's End Game [View instapost]Jun 19, 2013. 11:33 AM | 0 Likes |Link to Comment
Protected Principal Retirement Strategy: Portfolio Update [View article]
Akaralph, would you please let me know if you were owning MIN what would you do?
I`ve read articles after I bought MIN that the bond market will be the worst performer in 2013, should I just quit and move to stocks now?May 28, 2013. 11:03 PM | 0 Likes |Link to Comment
Protected Principal Retirement Strategy: Portfolio Update [View article]May 22, 2013. 08:48 PM | 0 Likes |Link to Comment
Thrilling Friday 15,000 Finish [View article]
I very much like your view and style.
Unfortunately I`m a saver with not much money invested in stocks.
I came to realize that 7-10% inflation on my wealth is getting equal to what I`m able to put aside from my annual salary.
So basically I`m working for free for a corporation from this year :)
I`m debating if this is the right time for me to learn and jump into stocks as it seems to me the situation is more dangerous than ever.May 10, 2013. 10:02 PM | 0 Likes |Link to Comment
The Spark That Ignites A Hyperbolic Rise In Silver And Gold [View article]
So that means with a 30-year loan, in 10 years the amount I need to pay month by month will be a joke compared to my salary.
I don`t get it why people say inflation is coming, get rid of debt !
I think just the opposite.Feb 10, 2013. 10:27 AM | 1 Like |Link to Comment
When To Worry About Inflation [View article]
I`ve been to many other countries and have not seen such richness anywhere else. When I drive around the US neighborhood
four-six cars on front of every house, swimming pools, nice garden, RV in the back or a boat or both. Gas hits $4 and people are whining like babies. Let me tell you that in Europe 1 gallon is around 8-12 USD, depends which country.
Yeah, time may have come when you need to think! where you spend your money.Feb 10, 2013. 01:08 AM | 1 Like |Link to Comment
The U.S. Debt Crisis Explained In Layman's Terms [View article]
Why is it a big problem if US owes money to others? How they will take it back?
It is like some kids are 6 years old and lend money to the 13 years old big fat buddy at the end of the street. One they they may want to get back the loan, how they`re going to get it back?
It seems to me our politicians also feel very safe behind the destroyers, and drones and this army overall.Feb 5, 2013. 03:07 PM | 0 Likes |Link to Comment


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MaydanSF is a platform created by Ukrainians living in the San Francisco Bay Area to support Ukraine in its fight for Democracy, Independence, and Freedom. Our current goal is to help Ukraine stand up to Russian aggression by bringing awareness to people in the SF Bay Area about events in Ukraine, so that we can all support Ukraine together. MaydanSF collects donations and sends help to Ukrainian army. We arrange for the purchase and shipment of needed equipment directly to Ukrainian soldiers and army volunteers. We report all spending and purchases here, on our facebook page. Brave Ukrainian people are fighting for the Country's freedom now, they need our help.
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Updated last 2 pics!! Here it is!! Her nursery is 99.9% complete!! Pics included :)
Posted 01/27/2013
Beautiful! My little girl will share our room until we move then our girls will share a room
Ritakanet · Original Poster
Posted 01/27/2013
Thank you!!! :)
First baby! Princess Mila arrived 2/21/13!!
Posted 01/27/2013
Posted 01/27/2013
what a diva princess lol. beautiful
Ritakanet · Original Poster
Posted 01/27/2013
Thank you!! I'm telling you camarochic, you and I in this business and were golden!! Lol
First baby! Princess Mila arrived 2/21/13!!
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Your growing child
Your 27-month-old: Parallel play
It's normal at this age for kids to do play separately even when they're together. Read More
Your 27-month-old: Becoming bilingual
Is now a good time to expose your child to other languages? Read More
Your 27-month-old: Mastering motor skills
Doing actions repeatedly helps your child perfect her motor skills. Read More
Your 27-month-old: Read it again
Five Little Monkeys Sitting in a Tree again?! Oh yes. Reading the same book over and over provides a measure of comfort. Read More
Your 28-month-old: Making friends
First friendships are very real to your child. Read More


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XtremeMac at 2012 CES: Multi-iPad Charging Stations
XtremeMac is showcasing a number of new products at the 2012 International CES. Included in the mix is the Tango TT, an audio charging dock for the iPod, iPhone, iPad featuring a flexible 30-pin dock connector, that allows the device to be docked in landscape or portrait orientation, a sliding back support that raises and lowers the device for multiple viewing angles, multi-directional speakers, an auxiliary input, and a companion app. It will be available this summer.
Also being shown is the Soma BT, a portable combination Bluetooth stereo speaker and battery pack for the iPod, iPhone, iPad, and other compatible devices. It features a 2W x 2 speaker setup with a passive radiator for improved low-end performance, an internal 1150mAh battery that provides up to six hours of playtime and can be used to charge a separate device over USB, a high-power microphone for hands-free calling, and a line-in jack for connecting non-Bluetooth audio devices. It will be available in the second quarter of 2012.
Available in Duo Plus, X3, or X5 versions—signifying the number of devices that can simultaneously be charged. There is a Dock Connector plug for each, so that they may stand in an orderly line and no additional cables are required. Pricing for the Duo Plus has yet to be announced, while the X3 and X5 will sell for $100 and $150, respectively. All three charging stations are expected to hit the market in Q1.
The company is also showing a 3-in-1 USB Mobile Cable that offers micro USB, mini USB and 30pin tethered tips, the InCharge Boost, a portable battery pack with a 2300 mAh lithium polymer battery, an integrated 30-pin connector and USB connector, an integrated carabiner, a dedicated on/off switch, and LED status indicators, and the InCharge Micro Boost, a 500 mAh battery pack, which also features an integrated carabiner, 30-pin connector, and LED status indicator lights. All three will be available in Q1; pricing on the 3-in-1 cable has yet to be revealed, while the InCharge Boost and InCharge Micro Boost will sell for $50 and $25, respectively.
Finally, the company is showing a variety of cases, including options for the iPad, iPhone, and MacBook.
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Silicon Valley Soap Box Derby
Welcome to the greatest amateur racing program in the world. Please use the links above to learn more about our program, check past results, learn about future events, or just browse our growing library of pictures and movies of past races and past racers.
Visit us on Facebook
2015 Local Winners:
Amanda McVey – Super Stock
Anna Genna – Stock


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Rugby Union
Select a team
Six Nations
- England
- France
- Ireland
- Italy
- Scotland
- Wales
Aviva Premiership
- Bath
- Exeter
- Gloucester
- Harlequins
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- London Welsh
- Newcastle
- Northampton
- Sale
- Saracens
- Wasps
The Rugby Championship
- Australia
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Guinness PRO12
- Cardiff Blues
- Connacht
- Dragons
- Edinburgh
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- Leinster
- Munster
- Ospreys
- Scarlets
- Treviso
- Ulster
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Top 14
- Bayonne
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- Clermont Auvergne
- Lyon
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- Racing Metro
- Stade Francais
- Toulon
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|Home team
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|53 - 24
Match Links
- Aviva Premiership
- 2nd Apr 2011
- Ground: Franklin's Gardens
- Att: 13,312
Mallinder hails eight-try Saints
Try-chasing tactic a joint decision between coaches and players
Related links
Also see
Northampton boss Jim Mallinder praised his side's attacking play in the wake of their eight-try victory over Sale on Saturday.
The Saints director of rugby said it had been a joint decision between coaching staff and players to chase tries rather than kick their penalty opportunities during the game.
And the tactic paid off, with half of the hosts' tries coming as a direct result of the policy.
"It's about reading the situation," said Mallinder. "And when your forwards are in so much control it makes sense to keep the pressure on.
"The players know how the mauls and scrums are going and whether or not they should kick their goals."
Mallinder was particularly pleased with his pack, whose domination throughout the clash forced two penalty tries.
"Sale were struggling a little bit up front," he added. "But they put us under a lot of pressure in the first 40 or 50 minutes."
"They will have been disappointed to lose Peel to injury, and then with the sending-off.
"But they have some good players and people like Charlie Hodgson can make them play. At half-time we were still not in the clear, despite scoring our first-half tries."
The win provides Saints with a boost ahead next weekend's Heineken Cup quarter-final against Ulster at Milton Keynes.
But Mallinder is under no Illusions that his side will have to remain at the top of their game if they are to secure a place in the last four. "It's going to be a really tough game, but it's one we are capable of winning," he insisted.
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|Aviva Premiership
|Saturday 30th May
|Aviva Premiership
|Bath 16 - 28 Saracens
|Saturday 23rd May
|Bath 47 - 10 Leicester Tigers
|Northampton 24 - 29 Saracens
|Saturday 16th May
|Exeter 44 - 16 Sale Sharks
|Leicester Tigers 22 - 14 Northampton
|Bath 50 - 30 Gloucester
|Newcastle Falcons 37 - 21 Harlequins
|London Irish 40 - 40 Wasps
|London Welsh 17 - 68 Saracens
Experts & Blogs
Phil Edwards
Read the thoughts and opinions of Phil Edwards with skysports.com


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It's not 'new news' that the real estate market has picked up in many parts of the country. Though lots of buyers are out shopping, inventory is still low. Nobody can predict when that situation will improve, of course. But large national home builders, as well as small local ones, are buying up land, getting plans drawn up, and starting construction on new homes.
But is a new-construction home the right path for you?
The folks at
Synergy Real Estate Group: http://nwarkansashomes.com/
RLP Construction
and Highlands Mortgage: http://highlandsmortgage.com/
Can help!


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Buy houses in Copnor Road, Portsmouth PO3 - 2 bedrooms
Portchester Road, Portsmouth PO2Terraced house for sale - 2 bedrooms
No Forward Chain! This two bedroom, bay and forecourt house is located along Portchester Road, North End. This, in our opinion, well presented property boasts two double bedrooms, a 10'4 4 piece upstairs bathroom, two reception rooms, an 11' fitted ... More details
Note: Distances are straight line measurements
- Fratton (1.2 miles)
- Hilsea (1.2 miles)
Marketed by Jeffries, PO2. Call 023 9233 3313£176,500
Beresford Road, Portsmouth PO2Semi-detached house for sale - 2 bedrooms
Don't miss out on the opportunity to purchase this two double bedroom, semi detached house located in Beresford Road, North End and offered with No Forward Chain. In our opinion this spacious property boasts a range of desirable features including two ... More details
Note: Distances are straight line measurements
- Hilsea (1.1 miles)
- Fratton (1.4 miles)
Marketed by Jeffries, PO2. Call 023 9233 3313


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Reel World
By Devin D. O'Leary
Cup Runneth Over
Film Review
Girls Rock!
This one time, at band camp, I learned how to bring the noise
By Marisa Demarco
Film Review
Kung Fu Panda
Animated martial arts fable kicks it up a notch
By Devin D. O'Leary
Idiot Box
Hero Worship
"Comic Books Unbound" on Starz
By Devin D. O'Leary
Week in Sloth
The Week in Sloth
Today's Events
The Thing (1982) at KiMo Theatre
See John Carpenter's rendition of The Thing, featuring Kurt Russell and Wilford Brimley. Part of the Friday Fright Nights film series.
The Overnight at CCA Cinematheque
Tomorrow's Events
A Butterfly for Brooklyn at Belen Public LibraryMore Recommented Events ››
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14 years of experience
Accepting new patients
14 years of experience
Accepting new patients
167 N Main St
Tuba City, AZ 86045 Phone number & directions
Tuba City, AZ 86045 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Frank Dalichow:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
Have you visited Dr. Dalichow? Share your experience.
Write a Review
Write a Review
Specialties & Research
Dr. Frank Dalichow, MD is board certified in Internal Medicine.
Education & Awards
Dr. Dalichow graduated from New York Medical College, Valhalla.
Dr. Dalichow has 1 hospital affiliations:
- Tuba City Regional Health Care
Home > Find an Internist > AZ > Tuba City Internists > Dr. Frank Dalichow, MD
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- Additional Information
- Dr. Frank Eckhard Dalichow MD is a male Internist, has 14 years of experience and practices in Internal Medicine.
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- Dr. Frank Dalichow has 1 office location.
Dr. Frank Dalichow practices Internal Medicine near Tuba City, AZ.
See Tuba City Internists.


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On Feb. 10, the Northrop Grumman Corporation-built (NYSE:NOC) amphibious assault ship Makin Island (LHD 8) returned from successful three-day builder's sea trials held in the Gulf of Mexico. The ship is the eighth USS Wasp (LHD 1)-class amphibious assault ship being built by the company at its Gulf Coast facilities in Pascagoula, Miss.
"We worked collaboratively with the Navy to meet our program commitments, and complete this significant milestone," said Irwin F. Edenzon, sector vice president and general manager of Northrop Grumman Shipbuilding-Gulf Coast. "Our shipbuilders did an outstanding job overcoming some challenges in building the nation's most sophisticated LHD to-date. We are confident the Gulf Coast team will continue the steady progress made on LHD 8, and we're on our way to a second quarter 2009 delivery."
During builder's trials, Makin Island performed all required sea trial evolutions during the three days, including the operational achievement of the first gas turbine/electric-powered propulsion system ever used on large deck amphibious assault ships. The gas turbine engines and electric drive will provide significant ship life-cycle savings in manpower and maintenance costs over previous ships.
"The Navy and industry team overcame many challenges in getting to this trial," said U.S. Navy Capt. Jeffery Riedel, program manager of Amphibious Warfare Programs for PEO Ships. "The ship performed very well. This was the first time an LHD obtained full power on both Gas Turbines and on its electric drive. I look forward to acceptance trials and delivering Makin Island to the fleet."
The Gulf Coast shipbuilding team met several other milestones paving the way for builder's sea trials including the resolution of critical electrical cabling installation issues and a significant integrated propulsion system testing program. The Northrop Grumman Shipbuilding-Gulf Coast test and trials team will join U.S. Navy personnel at-sea for Makin Island acceptance trials.
The Makin Island is 844 ft long and 106 ft wide and weighs 42,800 tons. Its 70,000 horsepower hybrid propulsion system will drive it to speeds in excess of 20 knots. As a multi-purpose amphibious assault ship, it is designed to transport and land a Marine Expeditionary Unit, a force of almost 2,000 Marines, ashore by helicopter, landing craft and amphibious assault vehicle. It will also have secondary missions of sea control and power projection by helicopter and fixed-wing vertical short take-off and landing aircraft; command and control; and mission support, including a hospital with six operating rooms.
Makin Island is scheduled for commissioning at her San Diego homeport in October 2009.
The expansion of the number of wind turbines out at sea near the northern Dutch coast was reason enough for Ubels Offshore to expand its fleet with a fifth ship last year.
Hamburg based shipping company Hapag-Lloyd plans for 24 of the largest containerships in its fleet to get new bulbous bows by 2016, with some of the vessels also
In 2015 two significant developments are going to make many operators, owners and builders of professional vessels consider hybrid marine power. Firstly the new emissions laws in ports,


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It is almost a truism that marketing has become highly technology-intensive. A nearly ubiquitous component of any marketing technology portfolio is email marketing. In fact, there is a high probability your company is already using some form of it, even though you might not be aware of it. A related component is marketing automation. Customers often talk of these in the same breath. In this article, we will look at this distinction in some detail and also summarize what marketers should know when evaluating these technologies.
May 05, 2010
Above the Clouds: Managing Risk in the World of Cloud Computing Kevin T. McDonaldIT Governance Ltd.Paperback, Ebook$39.95
Cloud computing can save companies money without putting business information at risk. That is the message in Above the Clouds: Managing Risk in the World of Cloud Computing, a new book by cybersecurity expert Kevin T. McDonald, senior critical infrastructure protection (CIP) and cybersecurity analyst for ICF International, a leading provider of consulting services and technology solutions to government and commercial clients.
Through cloud computing, a company's information technology (IT) functions are moved to an external, shared service provider and accessed over the internet. Data is no longer stored in-house, and the company no longer owns software applications. Above the Clouds explains the potential benefits of adopting this approach.
Get Seen: Online Video Secrets to Building Your Business Steve GarfieldWileyHardcover$24.95
In the past year, the world of online video exploded. Hollywood got into the game, professional actors and writers joined in, and independent producers looked to find their niche. Now, companies are wide awake to the opportunities for product and brand promotion as well as customer engagement. So how do you want to fit into the new online video universe?
The must-have guide, Get Seen by Steve Garfield, the "Paul Revere of video blogging," offers a quick and complete toolkit to get you up-to-speed on the latest that online video and related media have to offer. This book examines success stories of how companies have used online video; presents a series of plans and tools that businesses can follow as they expand onto the social web; provides clear step-by-step directions on how to record, edit, and export videos; where to post them; how to build a community around their content; and what to do to increase views by making them go viral.
The new rules of social media are constantly changing. Video is the ideal way to tell your story; it can lead to more business. If you're ready to take full advantage of the newest resource in the social media arsenal, Get Seen is the guidebook you need.


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Please update your stories
The Enemy. My Love. My Mate. My Curse
if you had only two months to live unless you mated what would you do? Kaitlyn has never wanted a mate b...
******I'm thinking of starting to re-vamp or just update my stories soon so look out for that.******
I'm just your average male* medical student obsessed with anime/manga, along with yaoi.
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if you had only two months to live unless you mated what would you do? Kaitlyn has never wanted a mate b...
Jennifer has constantly been on the move for over three hundred years in an attempt to seem human. This...
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im half ... book love it please update
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Sunday, September 13, 2015
**Please note that online registration is the only means of registering for Open House. Please check back - registration is expected to be live in July.
Please check back for the schedule for the fall Open House. We look forward to seeing you!
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Original recipe yields 14 servings
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This recipe will make you a rock star! I have made it for the last 2 years as Christmas gifts, and my German friends all comment on how it reminds them of the holidays from when they were littl...
This is wonderful, I will add more ginger next time but really is great as is. I'll definitely make it again!!!


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My girlfriend and I were so lucky to find a place to stay here, we were two stranded ladies stuck in Tahoe in the midst of a crazy snowstorm (even the highway was closed!). This hostel was close to the highway exit (for Sugarbowl, Donner Ski Ranch). This is a new family business -- a combo hostel and restaurant run... More
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A battery monitoring system (10) supplies the user of a battery power system with information indicating the capacity remaining in the battery (9) during discharge. During discharge the system (10) monitors various parameters and calculates on a rapid sampling basis derived parameters from algorithms stored in memory in tabulated form. The recharging efficiency is also evaluated, stored and updated on each charge/discharge cycle so that ageing of the battery (9) is monitored.
1. A battery monitoring system comprising:
current measuring means for evaluating the level of instantaneous current drawn from a battery when supplying a load;
voltage measuring means for evaluating the level of instantaneous battery voltage when the battery is supplying the load;
means for selecting a final battery voltage level at which the capacity of the battery is to be considered exhausted; and
arithmetic means for continuously receiving measurement values outputted from said means and for computing continuously on a rapid sampling basis a measure of remaining battery life;
wherein said arithmetic means comprises:
a first arithmetic unit (13-16) for computing the instantaneous power level delivered by the battery and for evaluating continuously on a rapid sampling basis according to a first predetermined algorithm the total discharge duration (T) available from the battery when continuing to supply power at the measured instantaneous power level based upon the selected final battery voltage level;
a second arithmetic unit (17) for evaluating continuously on a rapid sampling basis according to a second predetermined algorithm a measure of elapsed discharge time (t) from the measured instantaneous battery voltage and battery current;
a third arithmetic unit (18) for evaluating continuously on a rapid sampling basis the remaining life of the battery if it continues to supply power at the measured instantaneous power level, by subtracting the measure evaluated by the second arithmetic unit (17) from that evaluated by the first arithmetic unit (13-16); and wherein
(i) said first predetermined algorithm comprises the hyperbolic equation
T=a+b(if)-1 +c(if)-2
where a,b,c are co-efficients which are a function of the final battery voltage level and which are held in sets in a storage table to be outputted according to the selected final battery voltage level; and
(i) said second predetermined algorithm comprises the cubic equation
V=A+Bt+Ct2 +Dt3
where A,B,C,D are co-efficients which are a function of instanteneous battery current (ip), and which are held in sets in a storage table to be outputted according to the measured value of instantaneous battery current (ip), and V is the measured value of instantaneous battery voltage.
2. A system as claimed in claim 1, wherein a temperature sensor is provided for monitoring battery temperature, the temperature sensor output being connected to the current measuring means to establish a temperature-corrected measure of the instantaneous current drawn from the battery and which temperature-corrected current measure is outputted to the arithmetic means.
3. A system as claimed in claim 2, wherein the first arithmetic unit and the second arithmetic unit each includes interpolation means to establish co-efficients of value intermediate those stored by the respective table.
This is a continuation of application Ser. No. 07/852,193, filed on May 29, 1992, now abandoned.
This invention relates to a battery monitoring system.
In the use of battery operated equipment, such as battery powered electric vehicles and standby power systems, it is desirable to monitor the battery in order to provide from time to time a prediction informing the user of the remaining capacity in the battery.
It is an object of the present invention to provide a battery monitoring system.
According to the present invention a battery monitoring system comprises,
first means for evaluating the level of instantaneous current drawn from a battery when supplying a load;
second means for evaluating the level of instantaneous battery voltage;
third means for computing from the output of the first and second means the level of instantaneous power delivered by the battery;
fourth means for determining a final battery voltage level at which the capacity of the battery is exhausted;
fifth means for evaluating from the output of the third and fourth means the estimated final battery current;
sixth means for calculating according to a first predetermined algorithm the total discharge duration of the battery according to the outputs of the fourth and fifth means;
seventh means for calculating according to a second predetermined algorithm the accumulated discharge duration according to the output of the first and second means;
eighth means for assessing the remaining discharge duration available from the battery from the outputs of the sixth and seventh means;
wherein said first predetermined algorithm comprises a hyperbolic equation having first co-efficients selected from a stored table of such first co-efficients by the output of the fourth means, and said second predetermined algorithm comprises a cubic equation having second co-efficients selected from a stored table of such second co-efficients by the output of said first means.
An embodiment of the present invention will now be described with reference to the accompany drawings in which:
FIG. 1 schematically illustrates a battery monitoring system according to the present invention; and
FIG. 2 illustrates two typical discharge curves, the upper set of curves illustrating a discharge rate of 15.5% of a 10 hour battery capacity, and the lower set of curves illustrating an 18% discharge rate, the solid lines reflecting data issued by the battery manufacturer and the broken lines reflecting evaluations using the cubic equation of box 17 of FIG. 1.
A battery monitoring system 10 in accordance with the present invention is illustrated in FIG. 1 and monitors the condition of battery 9 which is connected to supply a load 8. System 10 comprises a first evaluating arrangement 11 for evaluating the level of instantaneous current drawn from the battery 9, and a second evaluating arrangement 12 for evaluating the level of instantaneous battery voltage. The outputs of arrangements 11 and 12 are fed to a third arrangement 13 which computes the level of instantaneous power delivered by the battery. A fourth arrangement 14, in this embodiment containing a preset value, determines a final voltage level for the battery 9 when the capacity of the battery is exhausted and the outputs of arrangements 13 and 14 are delivered to a fifth arrangement 15 which evaluates the estimated final battery current. The output of arrangement 15, together with the output of arrangement 14, is delivered to a sixth arrangement 16 for calculating according to a first predetermined algorithm (as will be explained) the total discharge duration of the battery 9.
The outputs of the first and second arrangements 11, 12, in addition to being fed to the third arrangement 13 are fed to a seventh arrangement 17 which is arranged to evaluate according to a second predetermined algorithm (as will be explained) the accumulated discharge duration and the outputs of the sixth and seventh arrangements 16, 17, are fed to an eighth arrangement 18 which evaluates the remaining discharge duration available from the battery 9.
The algorithms which are used in the system 10 are formulated on the basis of the output from first arrangement 11 being in a normalised form, in part this simply being a percentage of the ten hour discharge rate but in part being modified by variations in temperature of the battery 9 with respect to a predetermined temperature (usually 15� C.). Accordingly, a temperature sensor 21 is provided for sensing battery temperature and the output of sensor 21 operates an arrangement 22 to establish a temperature correction factor which is fed to the first arrangement 11. The arrangement 11 therefore comprises a current sensor 11A, a temperature normalising unit 11B and a scaling unit 11C.
The second arrangement 12 comprises a voltage sensor 12A, a stored value, 12B reflecting the number of individual cells within the specific battery 9 and an arithmetic unit 12C which provides the output for arrangement 12 so that the output is measured volts per cell. The third arrangement 13 evaluates the level of instantaneous power delivered by the battery by multiplication of the values delivered to it by the first and second arrangements 11, 12. The fourth arrangement 14 is provided in this example in a present manner, with the final voltage level of each cell and the fifth arrangement 15 contains a calculating unit 15A which by division of the power value delivered to it by arrangement 13 and the voltage measure delivered by arrangement 14 evaluates the final current and this is scaled by unit 15B to the ten hour discharge rate.
The sixth arrangement 16 comprises an arrangement 16A which stores a first set of co-efficients and which is arranged to output a single set of such co-efficients to unit 16B according to the voltage value provided to unit 16A by arrangement 14. Unit 16B is a calculation unit which evaluates a hyperbolic equation having specified co-efficients as delivered by unit 16A and a specified variable as delivered by unit 15B. The evaluation of this hyperbolic equation establishes a total duration of battery discharge.
The seventh arrangement 17 comprises a unit 17A which stores a table of second co-efficients and according to the value of scaled current delivered to it by unit 11C provides a specific set of such second co-efficients to a calculating unit 17B which is arranged to evaluate the accumulated discharge time from a predetermined cubic equation relating instantaneous voltage with accumulated discharge time.
The eighth unit 18 is arranged to subtract the values delivered to it by units 16 and 17 to thereby provide a measure of the remaining time to final discharge of the battery 9. Arrangement 18 may also express the remaining discharge time available as a percentage of the total discharge time or may express the accumulated discharge time as a percentage of the total discharge time.
The cubic equation evaluated by unit 17B is derived from graphical data provided by battery manufacturers expressing the relationship between measured battery voltage and accumulated discharge time for a particular level of instantaneous current. It has been found that the divergence between the graphical data and the cubic equation is minimal as illustrated by FIG. 2 and by storing sets of co-efficients in unit 18A for particular values of current a substantial reduction of storage space is achieved together with an increased ability to interpolate for unstored sets of co-efficients. Likewise the hyperbolic equation evaluated by unit 16B is derived from graphical data provided by battery manufacturers expressing the total discharge period to a particular value of final battery voltage for a series of specific values of instantaneous battery voltage and the divergence between the hyperbolic equation and the graphical data is negligible. Interpolation of unstored co-efficients for the hyperbolic equation is readily effected by unit 16A.
By way of operation of the system 10 a specific example will now be evaluated for a battery of the lead acid HCP17 type having the following parameters:
______________________________________Ampere hour rate 800 = 10 hour capacityNo. of cells 164Temperature correction factor 1% per �C.Rated temperature 15� C.Final voltage 294Final volt/cell 1.79______________________________________
The following measurements are taken:
______________________________________Current 146 AmperesVoltage 314.8 VoltsTemperature 20� C.______________________________________
1) Sensor 11A measures the present current (iin) flowing through the battery leads as +146 amps, the positive sign indicating that the battery is being discharged.
Unit 11B normalises iin to rated temperature (15� C.) and because the measured temperature in the battery room is 20� C. the temperature correction factor provided by unit 22 is:
so that the temperature-corrected discharge current is 146.0�1.05=139.05
Unit 11C calculates current ip in terms of the 10 hour capacity of the battery, to give a percentage, so that the output of arrangement 11 is:
ip =(139.05�100)�800=17.38%
2) Sensor 12A measures the battery voltage as 314.8 volts d.c.
Unit 12B divides the battery voltage by the number of cells (164) to give cell voltage:
vin =314.8/164=1.9195
3) Arrangement 13 calculates power demand.
Power=vin �ip =1.9195�139.05=266.90 watts
4) Unit 15A calculates final current
if =power/vf
(vf is the preset final voltage, i.e. 1.79 established in arrangement 14).
if =266.90/1.79=149.11 amps
and this is scaled by unit 15B to be 18.64% of the 10 hour capacity.
5) Arrangement 16 calculates the finish time T, using final current (if) from a hyperbolic equation of the form
T=a+bi-1 +cif -2
where the hyperbolic co-efficients (a,b,c) are stored in unit 16A for specified final voltage values; e.g.
______________________________________Final volts a b c______________________________________1.85 -111.738 6662.29 3942.71.83 -95.1394 6645.34 5171.711.81 -87.7079 6939.18 3580.981.79 -74.9541 6913.18 3857.271.77 -65.1906 6880.4 4634.921.75 -56.4163 6826.9 5202.11______________________________________
From the above table unit 16A selects the co-efficients for the set end point voltage of 1.79:
______________________________________1.79 -74.9541 6913.18 3857.27______________________________________
and the finish time T for the specified final current of 18.64% is calculated using the hyperbolic equation:
6) Unit 17 calculates the accumulated discharge time t from a cubic equation of the form
V=a+bt+ct2 +dt3
where the cubic co-efficients (a,b,c,d) are stored in unit 17A for specified levels of current ip, e.g.
TABLE I______________________________________i p a b c d______________________________________172 1.655 -4.392 E-3 5.426 E-4 -2.127 E-4142 1.710 -5.985 E-3 -4.174 E-4 2.164 E-5106 1.776 -4.722 E-3 2.348 E-5 -2.609 E-688 1.804 -2.839 E-3 -1.082 E-5 -7.787 E-771 1.837 -1.240 E-3 -2.965 E-5 -1.203 E-760 1.852 -7.024 E-2 -3.478 E-2 6.180 E-336.9 1.913 -4.214 E-2 -4.087 E-3 3.903 E-327 1.940 -3.234 E-2 5.836 E-3 -3.533 E-321.6 1.951 -1.648 E-2 6.957 E-4 -1.331 E-318 1.964 -1.382 E-2 5.565 E-5 -5.936 E-417.38 1.96496 -1.432 E-2 5.77 E-4 -5.8 E-415.5 1.968 -1.592 E-2 2.232 E-3 -5.632 E-413.6 1.972 -1.361 E-2 2.811 E-3 -5.399 E-412.1 1.977 -1.277 E-2 2.092 E-3 -3.312 E-411 1.982 -1.310 E-2 2.065 E-3 -2.759 E-410 1.986 -9.299 E-3 1.381 E-3 -1.860 E-4______________________________________
(where E-2 represents 10-2 etc.) Accordingly the cubic equation is:
V=a+b�t+c�t2 +d�t3
We know the following variables
V=cell voltage=1.9195
a=calculated coefficient=1.96496
b=calculated coefficient=-0.01432
c=calculated coefficient=0.000577
d=calculated coefficient=-0.00058
and unit 17B solves this equation, by iteration, for t, the result being t=161 minutes.
7) Arrangement 18 evaluates the remaining time as the difference between final time and present time ##EQU1## so that if the discharge continues at the present rate the battery will last for a further 146 minutes.
Additionally arrangement 18 may evaluate the percent discharge remaining as ##EQU2## so that the battery has 47.5% of its charge remaining.
It will be appreciated that in the foregoing example, for both the cubic and hyperbolic equations the sets of stored co-efficients and their identifier contain an identifier equal in value to that produced by arrangement 11 and by arrangement 14 but, particularly for arrangement 11 which outputs a measure of instantaneous current which is likely continuously to change, there is no guarantee that the evaluated current value is identical to an identifier within store unit 17A. Accordingly, unit 17A is adapted to interpolate between the nearest stored identifiers and their stored co-efficients to obtain the required identifier and required co-efficients.
For example, in the event that the identifier and its co-efficients are not stored in unit 17A interpolation is made between the co-efficients stored for stored identifier 18.0 and those of stored identifier 15.5 (see the previous Table I) by calculating the ratio that 17.38 is between 15.5 and 18.0 (76%) and for each stored co-efficient evaluating the interpolated value. Thus, taking co-efficient a as the example: ##EQU3##
Interpolation may be carried out on a similar basis by unit 16A in the case where the final voltage Vf is not a preset value as dictated by the battery manufacturers which is normally a value specifically contained as an identifier in store unit 16A.
It will be understood that in the system 10 which has been described the system outputs on a continuous (very rapid sampling) basis the prediction of the battery capacity remaining at any point in time and this prediction can, if so desired, be used to set or operate alarm devices guarding the battery and load arrangement.
The system 10 may be modified to incorporate a self-learning regime by comparing the projected discharge of the battery 9 with the actual discharge by means of which the system 10 self-adjusts for inefficiencies of the battery and load arrangement and for battery ageing. This is achieved using "electrically erasable programmable read only memory" (EEPROM). Each time a discharge takes place, the system 10 records all the vital parameters and then integrates them with previously stored derived measurements.
For example calculations made during the discharge and recharge of the battery allow the system to calculate the effective "charging efficiency". That is to say the percentage of energy that has to be returned to the battery in order to return it to the fully charged state or to a predetermined percentage thereof. To achieve this the system stores the following data for each charge/discharge cycle:
Battery energy level at end of discharge (EEPD).
Energy returned to battery during recharge (ER).
Battery energy level at start of next discharge (ESND). The charging efficiency can be expressed as: ##EQU4## The result from each charge/discharge cycle is integrated into a continuous store, the "historical charge efficiency". The system therefore "learns" the charging efficiency of the battery, load and charging unit.
Logging of previous recharge rates, times and efficiencies allow the system to indicate the predicted recharge time required to return the battery to a charged state. In order to calculate the required recharge time the system records one further parameter:
Charge Rate (CR) Expressed in Ampere/minutes
and derives
Depth of Discharge (DD) as % Fully Charged energy level
The recharge time then can be expressed as: ##EQU5## where BC is the Battery Capacity expressed in Ampere/minutes. All the above variables are stored in electrically erasable programmable read only memory (EEPROM).
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The latest album from Portland native Tara Jane O'Neil is barren, sparse, and quite precious. From the lullaby instrumental "Primer", the musician moves into a quasi-Celtic folk feel with "A Partridge Song", bringing to mind the likes of Judy Collins or Joan Baez. Downbeat and morose, some of the songs come to life in this framework, especially "The Louder", which could have come from an Elliott Smith tribute album. O'Neil seems to have a light, flighty timbre in her voice during the simple but elegant "A Sparrow Song", as does the somber, Cowboy Junkies-tinged "Blue Light Room", which she shines on from start to finish. Just as gorgeous is the almost hypnotic "Need No Pony" that resembles an acoustic version of an Arcade Fire classic. One number that doesn't measure up is "The Looking Box". But generally, O'Neil manages to get the most out of these songs for an engaging, enjoyable, and soothing record.
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Additional Features ACES Because the Customer Management SERVICE CENTERS Tool is Internet-based, it allows inter- operability between installations and Relevant & Ready headquarters. Counselors may provide counseling services at any education center GUIDE TO once they are added to the coun- selor access list. IMCOM ACES - Counselors have oversight of cus- tomers waiting. CUSTOMER - Counselors move customers from the waiting to the service area and sign them out . MANAGEMMENT TOOL (CMT) The region can view customers wait- ing and those serviced at all education centers within the region to ensure SERVICES proper usage and address problems Directs customer traffic with the system. Enables counselor oversight of the waiting area Encourages greater customer feedback Provides hard statistical data for: - Reports - Improved Services IMCOM ACES April 2007 IMCOM ACES CMT Requirements Counselor Screen CHANGES NETCOM/DOIM approval Counselors view the names of customers Dedicated PC with static IP address for who are currently waiting to be serviced. Reorganization into ACES customer interface Once the customer enters the coun- Service Centers (hubs) that No customer access to any site other selor's office, the counselor will move the service one or more satellite than the CMT sign in screen customer's name from the waiting to the centers or locations. service area. User access list to control usage and New business practices that Upon completion of the counseling ses- the level of access allow for the most efficient and sion, the counselor will sign the customer effective service to the customer, Staff access authenticated through out. while utilizing leading-edge AKO technology. Statistical Data Customer Sign In Screen CollabWorx (CWx), a collaborative meeting and Statistical data is used to provide information Customer is prompted to fill in title, training tool to enhance for reports, to defend manpower and need name, phone number, email address, communication between for resources, as well as to determine future status, branch, unit, and reason for visit education centers. service improvements such as change in op- If the customer has filled in the erational hours to meet customer needs, re- IMCOM Army Education information in a prior visit, all of the quired appointments, etc. Queries are avail- Website, providing fields automatically fill once the name able to provide figures and create charts for: convenient, online services to has been entered. The customer will Wait times customers. verify that the information is correct. Service Times Customer Management Customer asked if s/he has an Reasons for visits Tool (CMT), providing appointment, and if yes, selects the name of the counselor from a drop Customers who leave without being seen management of customer traffic, a means for additional down list Peak service hours customer feedback, and Customer offered to join a Listserv to Averages by installation, ACES Service Cen- accurate statistical data for receive current ACES information ter or region reports and service ICE link is sent to customer's email Combinations of data improvements. upon pressing the "Submit" button
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Campbell's Kitchen
Original recipe yields 4 servings
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This was quite a hit around here! I used the "soup ready" cream of mushroom soup that had veggies in it instead of the usual boring stuff and added almost twice as much garlic salt and basil to...
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This recipe was delicious, and I would defentetly reccomend this to people who aren't the best cooks. It was so easy, even the worst cooks could make it taste delicious!


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Mardi Gras - Page 3
Fun Times at the Minden Fasching Festival
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Party Gras 2015 Saturday, February 14th
Party Gras 2015 is Saturday, February 14th and it's THE WAY to celebrate Mardi Gras for the Krewe of Gemini parade.
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The Message audio Bible is now available on Bible Gateway! Click to learn more.
(queen or counsel).
+ Daughter of Haran and wife of her uncle Nahor, Abraham's brother, to whom she bore eight children. (Genesis 11:29; 22:20,23; 24:15,24,47)
+ The fourth daughter of Zelophehad. (Numbers 26:33; 27:1; 36:11; Joshua 17:3)


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How Infiniti climbed quality chart
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Ferrari's value to exceed $11 billion in IPO, Marchionne says
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NASCAR, sponsors cool on Confederate flag, but fans still fly it
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Dubai Holding appoints new managing director, CEO
HSBC Bank Oman agrees to sell Pakistan business to Meezan Bank
European tour operators evacuate thousands from Tunisia after attack
French group to invest at least $150 mln in Saudi's Kingdom Holding
Gold ticks up from 2-week low as market eyes Greece
Car bomb aimed at UAE officials kills three Somali soldiers in Mogadishu
Abu Dhabi's Etisalat jumps 13.8 pct on looser ownership curbs
RSE, Qatar teaming up to buy stake in Formula One
Qatar building boom proves a challenge for foreign construction firms
Still, a recent string of economic data suggests the economy may slow in the summer months and has caused the market to stall just shy of the four-year highs reached earlier in the month. A much sharper-than-expected decline in Midwestern business activity in April reported on Monday by an industry group was the latest evidence of a slowdown.
May 1, 2012 4:13 by kippreport


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Things to do
Today: The Community Music School Information Night -- 7-8:30 p.m. at the University of Memphis Music Building, Harris Auditorium, 3775 Central. The Community Music School at the U of M hosts an information night for those interested in signing up children for a spring music program, private lessons or piano classes. The evening conclude with a mini-recital by students. This event is free. Call (901) 678-4244 or visit Memphis.edu/cms.
Saturday: Harlem Globetrotters -- 7 p.m. at FedExForum. See the basketball team perform tricks, stunts and more. Tickets start at $19. Call (800) 745-3000 or visit Ticketmaster.com
Sunday: Search Party -- 3 p.m. at The Children's Museum of Memphis. Find clues and complete challenging tasks to win a prize. The search theme will be "Elvis," in honor of his birthday. Event is included with museum admission.
Monday: Pre-School Storytime -- 10:15 a.m. at the Benjamin L. Hooks Central Library, 3030 Poplar. Join the Central Library staff in the Children's Department for the first Monday preschool storytime of the year. This event is free, and for children ages 3-5.
Tuesday: My First Book Club -- 10 a.m. at The Children's Museum of Memphis. The staff will read Dr. Seuss's classic "The Foot Book" to teach about opposites. For children ages 2-4. Admission, $10.
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There are few things cuter than a little kid killing it on the ukulele.
Trainor brought along a ukulele to her audition and blew him away.
1896, from Hawaiian 'ukulele, literally "leaping flea," from 'uku "louse, flea" + lele "to fly, jump, leap." So called from the rapid motion of the fingers in playing it. It developed from a Portuguese instrument introduced to the islands c.1879.


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What Do Voters Think About State Abortion Restrictions?
Category: Abortion, State Fights
Across the country, huge numbers of people have spoken up to oppose politicians' attempts to restrict women's access to health care—packing statehouses, attending rallies, and calling their representatives. But politicians are pushing forward with these extreme and dangerous policies anyway, in spite of both public opinion and medical expertise.
It begs the question: If you're elected to represent your constituents, why aren't you listening to them?
Here are the facts:
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Unexpected elements like putting greens, water features, and an over-scaled chess game (seriously) make an unforgettable impression.
7 Herbs With Gorgeous Blooms
Deirdre Heekin and Caleb Barber added windows and French doors to a potting shed and turned it into a studio and guest room in their Vermont cottage.
In Mark D. Sikes's West Hollywood house, the backyard features a tiered garden. The first level is all brick, centered around the fountain.
11 Cookies With a Mouthwatering Surprise Inside


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Magnify objects and study them closely with the iOptron ST-80 Digital Microscope in silver. This microscope is easy to use and features zoom from 4x all the way to 24x. The fully coated glass-optics electronic eyepiece can capture images or videos on your computer so you can view them directly on the screen. This microscope also includes a tweezers, software, USB cable, an eyedropper, 2x Barlow Lens, prepared slides, blank slides and a carrying case.
Telescope Features: Focus Knob
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Lens Coating: Glass Optics, Fully Coated
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- Online Item #: 14502530
- Store Item Number (DPCI): 091-04-0464
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1994 Chrysler Concorde Q&A
1994 Chrysler Concorde Question: How can you change a fuel filter in this car?
The car turns over, so the battery, alternator, and starter are fine, and we just replaced the spark plugs, but now it won't start. We think it is the fuel filter, but we are not sure, how can you be sure it is the fuel filter? And do you have any insite on how it can be fixed. - massagegirl
2 Answers
Answer 1
do you have any eng codes? poss bad fuel pump or timing belt has broken - globalhelper
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Barry Bonds
Love him or hate him, San Francisco Giants slugger Barry Bonds did the unthinkable twice in the home run category. In 2001, Bonds hit 73 home runs, breaking Mark McGwire's single-season record of 70. And in 2007, Bonds became the all-time home run king when he slugged his 756th home run, surpassing Hank Aaron.(Photo: Ezra Shaw/Getty Images)
2015 NBA Free Agency Tracker07/02/2015
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6 Crazy Things Critics Will Say If LeBron James Loses Game 606/16/2015
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Sports Buzz: Orlando Spoils Derrick Rose's Return04/09/2015
Storylines to Follow in Duke-Wisconsin National Title Game04/06/2015
Sports Buzz: LeBron James Passes Ewing on NBA Scoring List04/03/2015


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iHerb Customer Reviews
Stretch Island, All-Natural Fruit Strips, Harvest Grape, 30 Strips, 0.5 oz (14 g) Each (Discontinued Item)
Customer Ratings
Reviews 5-star
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the best flavor
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Stavros S. Niarchos Foundation Fellowships for Excellence in Graduate Education
|Stavros S. Niarchos Foundation Fellowships for Excellence in Graduate Education
In celebration of the 70th anniversary of Canada-Greece Relations
Value &
The value of the Fellowship is to cover travel, tuition and living expenses:
March 1st*
|How to
Students submit an application form and required documents to the academic unit where he or she will be registered at McGill.
*If on a weekend or statutory holiday, submit on the next business day.
Preference will be given to incoming students
The candidate must
- be a citizen of Greece
- have permanent resident status in Greece,
- be enrolled in a full-time graduate research program at McGill,
- hold a First Class CGPA as determined by McGill.
Required Documents
To qualify, candidates must submit a complete application package containing the following documents:
- The Application Form duly completed, dated, and signed;
- ALL university level transcripts. OFFICIAL transcripts with OFFICIAL translations for any that are not in English or French
- Copy of proof of citizenship
- Copy of proof of residency in Greece:
a) Research experience: abilities you have gained through your past research experience or relevant work experience;
b) Relevant activities: professional and extracurricular activities in which you are involved that demonstrate your communication, interpersonal and leadership skills;
c) Research career: discuss your career goals and how the proposed program will contribute to your objectives;
d) Special circumstances (if applicable): Describe any special considerations that may have had an effect of your performance or productivity (e.g. delays in research results, gaps in your experience or academic background).
- Summary of Research Proposal (1 page maximum);
Selection Criteria
|Academic excellence
|As demonstrated by past academic results, transcripts, awards and distinctions; Academic record (first class average), Scholarships and awards held, Duration of previous studies, Type of program and courses pursued, Course load, Relative standing (if available)
|Research Potential
|As demonstrated by the proposed research; its potential contribution to the advancement of knowledge in the field, and any anticipated outcomes; significance, feasibility, and merit of proposed research, Scholarships and awards held, as well as by the applicant's research history
|Personal Characteristics
|As demonstrated by the applicant's personal statement; candidate's interest in discovery, and enthusiasm for research, leadership experience, academic and community involvement
|Recommendation of Academic Unit
|As demonstrated by the nomination letter


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Hello from MTTS2014: Day 1
Day one is now behind us and it's been an epic day! We're told that there were 1,400 MINI enthusiasts gathered at Golden Gate Fields this morning driving over 750 MINIs! Last night Todd and I attended the kick-off party at MINI of San Francisco, which was amazing! We walked around and talked to a few people that were there, listen in below.
Don't forget to play the home game with White Roof Radio on Instagram, Twitter and Facebook.
Written By: DB
Sort by MINI model
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MINI Model Cheat Sheet
1st Gen MINI
R50: One & MC Hatch
R52: All 1st Gen MINI Convt.
R53: MCS Hatch
2nd Gen MINI
R55: Clubman
R56: Hatch
R57: Convertible
R58: Coupe
R59: Roadster
R60: MINI Crossover
R61: MINI Crossover Coupe
3rd Gen MINI
F54: Clubman
F55: Five Door Hatch
F56: Hatch
F57: Convertible
F60: MINI Crossover
F58: Traveller
R50: One & MC Hatch
R52: All 1st Gen MINI Convt.
R53: MCS Hatch
2nd Gen MINI
R55: Clubman
R56: Hatch
R57: Convertible
R58: Coupe
R59: Roadster
R60: MINI Crossover
R61: MINI Crossover Coupe
3rd Gen MINI
F54: Clubman
F55: Five Door Hatch
F56: Hatch
F57: Convertible
F60: MINI Crossover
F58: Traveller
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R53 ('02-'06 MCS) Buyers Guide
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Camaro Textured Nylon Jacket - Graphite$79.00Lightweight, wind-resistant jacket constructed of waterproof and static-free nylon fabric with an overall diamond pattern texture. Two zippered front pockets, one zippered left chest pocket and one interior zippered pocket to secure valuables. Double zipper head for two way opening. Stow-away hood behind collar. Velcro™ adjustable cuffs. Embroidered Camaro logo on left chest. Shell: 100% nylon. Mesh lining: 100% polyester. Imported. Learn More
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Camaro Soft Shell Adventure Jacket - Grey$84.00Be ready for any adventure. This comfortable jacket will keep you warm and dry with its water-resistant and breathable smooth soft shell outer layer. Pockets everywhere you need them – inside and out. Zip-off hood (not shown) and adjustable Velcro® cuffs for a customized fit. Camaro logo embroidered on left chest. 95% polyester/5% spandex. Imported. Learn More


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Male , 31-35
Last Seen Now
Member Since Feb 09, 2010
Favorite Quote
- a little Austrian
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Politics Moderate
Horoscope Capricorn
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Local Time June 29th, 8:56 PM
Profile Whiteboard Recent Activity 62 Stories 1398 Experiences 158 Friends 24 Photos 3 Questions Trophies
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The Epic of GilgameshPaperback Penguin Epics
Free delivery worldwide
Dispatched in 2 business days
When will my order arrive?
- Publisher: Penguin Books Ltd
- Format: Paperback | 80 pages
- Dimensions: 110mm x 176mm x 8mm | 281g
- Publication date: 26 December 2006
- Publication City/Country: London
- Sales rank: 106,374
Product description
This work talks about a great king, strong as the stars in Heaven. Enkidu, a wild and mighty hero, is created by the gods to challenge the arrogant King Gilgamesh. But instead of killing each other, the two become friends. Travelling together to the Cedar Forest, they fight and slay the evil monster Humbaba. But when Enkidu is killed, his death haunts and breaks the mighty Gilgamesh. Terrified of mortality, he resolves to find the secret of eternal life.
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Author information
N. K. Sandars studied, soon after the war, with Professor Gordon Childe at the Institute of Archaeology, University of London, and took the diploma of the Institute. She continued to work at Oxford, taking a B.Litt. degree in the prehistory of Europe, and thereafter she worked on the prehistory of the Aegean, receiving a studentship at St. Hugh's College, Oxford, a scholarship from Oxford University and a travelling prize from the University of Liverpool. She has travelled extensively in Europe and in the Near and Middle East, and has taken part in excavations in the British Isles and overseas. She has contributed article to various journals and is the author of "Bronze Age Cultures in France," "Prehistoric Art in Europe," "Poems of Heaven and Hell from Ancient Mesopotamia," and "The Sea Peoples." She is a fellow the British Academy and of the Society of Antiquaries of London and a corresponding member of the German Archaeological Institute.
Review quote
"Andrew George has skillfully bridged the chasm between a scholarly re-edition and a popular work"--"London Review of Books" "Humankind's first literary achievement..."Gilgamesh "should compel us as the well-spring of which we are inheritors...Andrew George provides an excellent critical and historical introduction."--Paul Binding, "Independent on Sunday" "This volume will endure as one of the milestones markers...[George] expertly and easily conducts his readers on a delightful and moving epic journey."--Samuel A. Meier, "Times Literary Supplement" "Appealingly presented and very readably translated...it still comes as an exhilarating surprise to find the actions and emotions of the Sumerian superhero coming to us with absolute immediacy over 30-odd centuries.--"Scotsman" "Andrew George has formed an English text from the best of the tablets, differentiating his complex sources but allowing the general reader a clear run at one of the first enduring stories ever told."--Peter Stothard, "The Times" "An exemplary combination of scholarship and lucidity...very impressive...invaluable as a convenient guide to all the different strands which came together to produce the work we now call "Gilgamesh.""--Alan Wall, "Literary Review"


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ChuckysBaby's review of Unlisted Brand Color Oops - Regular Strength Hair Color Remover
94 reviews
77% would repurchase
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The 'Before Sunrise'/'Before Sunset' Team Are Getting Back Together
Warner Independent
Hawke spoke with the French site AlloCine, and because we don't speak French we had to rely on the nice people at Vulture to explain what the heck he said. They provided a translation:
"I don't know what we're going to do but I know the three of us have been talking a lot in the last six months," Hawke said. "All three of us have been having similar feelings that we're ready to revisit those characters. There's nine years between the first two movies and, if we made the film next summer, it would be nine years again so we've really started thinking that would be a good thing to do. We're going to try write it this year."
Yes, we're all sick of sequels, but we confess to being curious about how a third "Before" film would play out. Sort of like the appeal of the "7 Up" documentary series -- director Michael Apted goes back to interview the same group of people every seven years -- the "Before" movies have become about how these two characters have aged and changed over time. Plus, "Before Sunset" ended with a cliffhanger: Did they stay together or not? So unlike a lot of sequels, there actually is more to explore and discover. Sure, you could argue that the first two films were so good you wouldn't want them to screw the whole thing up with a bad third film. But, be honest: You've thought about these two people and wondered what happened to them. So have we.
Ethan Hawke and Julie Delpy to Begin Writing Third Before Sunrise Film [Vulture]


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Bill Gross thinks conditions are ripe for a liquidity crisis, and he points a finger at his old firm for its potential to be at the center of the storm.» Read More
Recently my friend Jennifer Wright at TheGloss.com came across another study purporting to show that men prefer to date women who are less intelligent than they are. She asked me about why this might be, assuming it was true at all.
I guess I can kind of see it.
Municipal bond defaults could hit the $100 billion market over the next five years, according to a new estimate from Roubini Global Economics.
This comes just after Moody's chief economist Mark Zandi estimated the chance of significant defaults to be zero.
Although $100 billion of defaults spread over five years would be much higher than the estimates of the muni optimists, his firm's figures would appear to be less cataclysmic than those suggested by Meredith Whitney.
As each day passes, with oil, gold and other commodities scaling either multi-year or historic highs, the denials of inflation become harder to maintain.
Call it the "inflation effect,"—the antithesis of Fed Chairman Ben Bernanke's "wealth effect" that helped convince Americans rising stock prices equated to greater wealth even while employment and housing lagged far behind.
In the case of inflation, some of the more conventional measures insist the phenomenon of too much money chasing too few goods has not taken hold. Government indicators for personal and producer prices remain tame, while there appears to be little of the wage pressure that also is a typical partner to rising inflation.
Ed Burns will play an unemployed former Bear Stearns employee in a new series produced by the creator of Entourage.
We have been seeing the budget battles of some states playing out in the form of protests and now more than ever the fiscal challenges facing many states are making headlines almost on a daily basis.
One of the expenditures states are required to pay for is providing Medicaid coverage and with the passage of health care reform more individuals will be rolled into the program.
On Tuesday, three governors—Haley Barbour (R-MS), Gary Herbert (R-UT) and Deval Patrick (D-MA) descended into Washington, testifying before the House Energy Commerce Committee on the burdens imposed by health care reform.
I caught up with two House members, both former practicing MD's—Rep. Michael Burgess \(R-TX\) and Rep. Paul Broun \(R-GA\) on the price tag of health care reform and the impact it could have on the quality of health care.
McKinsey & Co is reeling from the revelation that the Securities and Exchange Commission believes one of its most high-flying alumni gave corporate secrets to a hedge fund manager who is now accused of being at the center of a large and complex insider trading scheme.
For a firm that thrives on its reputation, proximity to misdeeds of this sort could be fatal, according to former McKinsey consultants who spoke on the condition of anonymity.
So, during tough economic times, you'd think people drink their sorrows away. Apparently not so much. I was surprised to find that US beer sales were down an estimated 2.7 percent by volume for the first half of 2010.
So who's winning? The craft, microbrews, like the newly-public Kona Brewing . The CEO rolled on set this morning in flipflops and a Hawaiian shirt, straight off the plane from paradise. \(Seriously, he gets paid to drink beer and live in Hawaii—tough life but someone's gotta do it.\)
Earlier this week the U.S. Treasury released its Preliminary Report on Foreign Holdings of U.S. Securities.
This report contains the preliminary revised annual numbers from the Department of Treasury.
As Cardiff Garcia at the Financial Times Alphaville explains , these revised annual reports are generally thought to be more accurate than the monthly Treasury International Capital System \(TIC\) data.
"Goldman knows, even though it's a mighty company, it survives at the sufferance of the U.S. government," Steve Forbes said as my guest host on the show this morning.
Nobel Prize-winning economist Robert Shiller says that his key valuation indicator is flashing warning signs.
The Fed is in the early stages of an analysis on changes in bond market liquidity, amid signs that liquidity may be less resilient than in past.
Janus Capital acquired a majority interest in Kapstream Capital and said Kapstream's Palghat will support Bill Gross as co-portfolio manager of the Janus Global Unconstrained Bond strategy.


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New Mutants 98 | 1st Deadpool | Cgc 9.8 | Mint White Pages For SaleLocated in Australia.
Welcome and hope you find something you will like and love.
Selling only due to study costs. I have one of the biggest Harley Quinn collections Now everything is being sold off.
I'm sorry I don't have the time to spend taking perfect pictures. I have study commitments.
International Buyers will be charged postage cost and for any special box I need to ensure it comes undamaged. Nothing more.
Any excess will be refunded. Postage for multiple purchases will be advised. You can thank the monopolistic Australia Post Office for excess charges.
Rough Guide for overseas: 1 comic $7 ; 2-3 comics $11; 3-5 comics $15.50.
Upto 1 kg Sea Mail is $20 or 1kg Airmail is $29 to the USA
International Postage for this Item includes Tracking
COMES IN MYLAR BAG and Backing Board
Mylar protects it against everything including sunlight.
I don't do the hard sell and I won't add the wonderful sales adjectives. You are well aware of what you are buying. It's down to you now
I think you will find that these items I list are extremely attractive for quality and investment.
You know you will be getting QUALITY from someone who is a Collector and knows how to care for his APPLY ON POSTAGE AS YOU WILL BE PAYING WHAT THEY CHARGE MEWHILE AND PAYPAL CHARGE THEIR FEES WHICH I DO NOT PASS OFF.Please be aware I will not pay extra postage charges like I have done before. I will advise the exact cost our astute Monopolistic Australia Post Office charges.If you do not like this then you can cancel. It's simple.
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New Mutants 98 | 1st Deadpool | Cgc 9.8 | Mint White Pages:
The Incredible Hulk 240 239 238 237 236 - 1968 Huge Run Lot
Vampirella #111 Warren Jan 1983 Vg
Vampirella #109 Warren Oct 1982 Fn
Harley Quinn #2 , 2nd Print Cgc 9. 8 The New 52
Wizard 1/2 Image & Top Cow "the Darkness" New With Certificate Of Authenticity
Vampirella #104 Warren Apr 1982 Vf
Underworld Unleashed Apokolips Dark Uprising #1 1995 Dc Comics Nm
Ms. Marvel Annual #1 Marvel Comics Nm/nm+ Unread
The Incredible Hulk 268 267 266 265 264 - 1968 Huge Run Lot
Vampire Tales 1st Appearance Of Morbius #1 Curtis By Marvel Vg+