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Hotel Arena
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TravelPod Member ReviewsHotel Arena Amsterdam
Well appointed hotel outside main part of Amsterdam (you need to access public transport to get around which was easy to find / navigate). Rooms very 'modern' with glass partitioning between bathroom / toilet & main lounge (if you never got the lighting right you will see a lot of your room mate!). Upstairs bed - rather steep. Lovely bar and food.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
Historical Traveler Reviews Hotel Arena Amsterdam
Arena Hotel - A great place to stay
The Arena hotel is simply one of the best budget hotels I've stayed at. It's a 10 minute tram ride from the centre and it's got everything you may need to enjoy a weekend break. The complex features a great bar, restaurant and nightclub as well as an amazing variety of rooms. We stayed in two of the rooms, we recommend them both:
C33 - This is what the hotel describes as a 'split level room'. It's quite narrow but it's really cool. It's the best 'split level room' in the hotel because it features a set of french doors that open into the garden. This is the only room that has this, so request this room if you are going for this type of accomodation.
On the second night, we asked if we could try one of the other rooms. We were sent to a room on the first floor that had not been done up, and had - as one of the reviewers said - scratches on the walls and looked quite dated. We were dissapointed so we called reception and on hearing this they immediately offered us one of their newest suites. Oh my God. This was not a suite, it was a mini appartment with two TV sets, a bathtub the size of a small swimming pool (honest) and beautiful decor. If you want to really enjoy your stay request this suite - the room number is 64. It's a bit more expensive than the 'split level' or 'first floor' level rooms but well worth it.
We had a fantastic dinner at the restaurant that came up to EURO 75, including two starters, two main courses a shared dessert, a bottle of excellect wine, water and a basket of bread. When was the last time you got this much in London? Exactly.
The breakfast is great too - plenty of breads, croissants, yoghurts, coffee and hot drinks and cooked eggs and bacon. Breakfast is included.\
The service overall was brilliant. I would recommend to anybody staying at the Amsterdam to speak to the staff if they are unhappy with their rooms or any element of their stay. They are really friendly and can't do enough for you.
I can see why some reviewers were dissapointed. The hotel's website is really good and it suggests that the hotel is more than it actually is. But, I would recommend this place to anybody who likes to stay somewhere different.
Business travellers will not find internet connection in the room. But then again, if you are staying at the Arena, you shouldn't be working all night, but enjoying the hotel's facilities.
There's a park nearby if you enjoy running, take your shorts and running shoes.
I would recommend the Arena to anybody going to Amsterdam. And I will defenitely stay there when I come back to this amazing city.
A ramshackle hostel!
We are all led to believe from the marketing and "image" this hotel tries to portray that it is an oasis of cool in what is (and i agree to this!) a very cool city. However, on arrival the dank room was full of flies, the shower next to useless with black mould on the grouting. The clencher was the broken blind which was straight out of Sarajevo! Nothing could justify the high room rates - but the breakfast and seating area outside provided 2 relative highlights. oh! a suggestion, stay somewhere more central... it will be worth it!
ArenA Hostel/Hotel, Trendy, Young, Overall, Pretty Cool
Arena Hostel - More like a hotel than a hostle, Arena is large, clean, relatively inexpensive & it also has a somewhat decent dance club. This place is perfect for the 18 - 35 crowd. Nearly everyone is young & trendy, etc. The location is safe, but a little out of the way, it's not far by tram though. The food at their bistro in the evenings is pretty damn good, and it is a pretty cool atmosphere. Too bad, it's not right in the middle of the Dam. Otherwise, a good value, we thought. I'm pretty picky! Amsterdam is fun, but not as quaint as I expected
Room average cool place
myself and my brother stayed in hotel arena last march and must say it has the greatest athmosphere and is really hip,the staff seem unfriendly at first but just ask a question and they are only too willing to help,our room was small but we were last minute,you could roam naked and no one seems to mind and thats what i loved about it,its not very central but walk five mins to underground station and it takes you to central station in minutes,I would love to stay there again
Hip but OK
We stayed here in early January 03. It is a cool place but we weren't very happy with our room. We reserved our room through STA travel so it was a hostel type of room and very cold. The shower and toliet were in the same room, nothing separating them so the water from the shower got all over the place! Our friends booked their room through the hotel, paid more but had a much nicer room--2 levels and warm. The breakfast was very good. The bar was fun.
Not for me
This is a 1 to 2 star hotel at best. The website makes it seem cool, but it's really more of an upscale youth hostel. I tried 2 different rooms, but then decided to say "thanks but no thanks" and left to find another hotel.
That said, it's a fun atmosphere, bar and club are cool and the people at the desk were very understanding.
A Fabulous Experience for Any Hip Traveller
My fiance and I just returned from a fantastic trip to Amsterdam...We stayed at the Arena Hotel, first in one of their absolutely perfect, couldn't-be-better large two floor rooms, and later in a medium room that was coolness in itself. Both rooms boasted super- high ceilings which I adored, huge windows, and hardwood floors. Our two-floor room came equipped with modern-art wallpaper, which we will never forget, and the medium room with cool lighting and 60's inspired chairs. The ultra-modern interior of the hotel contrasts beautifully with the old architechture and almost spooky exterior. The hotel staff were fantastic- after our initial check- in, we were not bothered for the rest of our trip. It was almost like having our own apartment, as the staff were unobtrusive and made it seem almost like they weren't there at all. We had never seen anything like it- all hotels should be so discreet.
The breakfast buffet in the morning must be the best in Amsterdam by far, served in the ultra-modern "To Drink" bar area of the hotel.
The only thing I can complain about is that it's a little outside the center of the city, but there's a tram station less than two minutes walking distance away, which solves the problem. Also, I believe in the summer it would make a beautiful walk into the center of Amsterdam...I can't wait to go back and find out if I'm right!!
In conclusion...If you want room service and pampering, the Arena is not for you. However, if you're hip, and going to Amsterdam for some time away from prying eyes and the everyday intrusions of society...the ARENA is The Place To BE.
I give it five stars because I can't rate it any higher.
Won't return to the Arena
Not convenient for walking to the city centre. Also, the rooms were ridiculously small, the door would barely open as the bed took up most of the floor space. The staff were not friendly at all, but thats not to say they were rude, just not too welcoming. I must say that the breakfast buffet was fantastic though. There was a huge selection of fresh food to choose from, by far the best I've come accross. I won't be going back though as it just was not within a short walk from the City Centre.
Arena is mod and hip
I loved the Hotel Arena. My husband and I stayed there in the spring of 2002. The staff was friendly and nice. The breakfast buffet has got to be the best in the city. It was plentiful and fresh. We felt pampered.
Convenient if you like to dance--a club is located in the building.
Wonderfull two-floor rooms
The Arena Hotel is a big 3 star hotel in the center of Amsterdam. My girlfriend and i had a two-Floor Room. Because of the high old rooms at the 18th Century. In the hotel there's a nightclub but we hered nothing in the room from the music. Breakfast was very good. We loved to stay their for 2 nights. Amsterdam itself is a very nicy city.
TripAdvisor Reviews Hotel Arena Amsterdam
Travel Blogs from Amsterdam
Canals and Museums
... closes at 8pm, and its already after 7pm, we are just not going to get into see this one - which is a real shame since Anne Frank's Diary was one of my first real primary school reads about WW2, and it made a lasting impression, but what can you do?
We had a booking for accommodation just outside Amsterdam itself, so, only seeing half of the things that we could have, we made for our hotel. Another big day tomorrow...but it will be nice if the sun continues to shine!
More Amsterdam, and last full tour day
... biblical scenes intended for private devotions while traveling! Who knew! Evalina told us that all of the treasures in the Rijksmuseum are available to be seen online at no cost! Check them out...my picture didn't turn out.
After this tour, we were on our own. We blitzed over to the Van Gogh--1.5 hour wait. Not. So we headed to the Dam for the best hot chocolate in the world, then went hunting for the Amsterdam Museum. Found it accidentally, and learned ...
Train to Amsterdam
Today we left Paris by train to Amsterdam. We arrived and liked the vibe of the city. Everybody was a bit more relaxed and there wasn't as much hustle and bustle as Paris. We checked into our hotel and soon we were ready to go for a walk. By this stage the sun had disappeared. We found a little restaurant called Poco Loco and had Tapas for dinner. We then took a walk through the red light ...
Underwhelmed in Amsterdam
... enamel; a wonderful selection of antique musical instruments; and some huge period dolls houses with incredibly detailed furnishings and figures. And all this housed in a gorgeous Gothic/Renaissance building, from the late 1880s, only reopened last year after extensive renovation, with elaborately decorated ceilings, stained glass windows, and a wonderful low-ceilinged basement. The only thing that I did not like about the museum, was that, ...
... to see to believe. Just don't take a wrong turn and end up wandering into the transgender district because after one double-take too many you can begin to look a little bit too interested.
Six-and-a-half hours is not nearly enough time to properly explore a city the size of Amsterdam. The day trip offers an affordable way to sample its many sights and sounds but if you can, find ...


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Hello, my name is Robbin Young. I'm a single, Caucasian woman, 5'6", 120 lbs, 36D-26-36, with no tattoos or piercings. I won Playboy's "Search For A James Bond Girl" contest, my prizes being a speaking role with '007' in a James Bond film and I was featured in a Playboy pictorial for the film. I've appeared in 6 (USA) & 8 (International) Playboy Magazine Pictorials, and am a former Playboy Bunny. I'm a SAG-AFTRA Actress, Printwork Model, Entertainer, and published Erotica Author. My goals are to be an Author and Motivational Speaker. And, yes, my photos are recent....I love being a 'Fantasy Woman' by changing my look with blonde, auburn, and brunette wigs...when Modeling, Acting, and Entertaining.
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Daniel Craig in 'Cowboys & Aliens': What the Reviewers Think
The actor's sci-fi-meets-western flick co-staring Harrison Ford hits theaters Friday.
Daniel Craig has mastered the tough-guy persona, he is the current James Bond after all. But, this weekend, the actor leaves the martini behind, replacing it daniel with a cowboy hat and lasso in Jon Favreau's sci-fi/western hybrid, Cowboys & Aliens, opening Friday.
See what reviewers are saying about the British actor's performance.
The Hollywood Reporter film critic Kirk Honeycutt writes that Craig's Jake Lonergan, the amnesia-addled stranger who rides into the western town of Absolution with a strange wrist adornment, "is not a man to be messed with."
STORY: 'Cowboys & Aliens' Daniel Craig: 5 Things to Know
Honeycutt, who praises director Favreau for letting "his actors do their thing," also adds, "that wrist accessory worn by Craig should be a merchandising stroke of genius."
The New York Times praised the actor saying he "makes for a surprisingly convincing cowboy." Adding that it's his onscreen presence that makes the character successful. "Mr. Craig, with his brutally handsome face and coiled physicality, looks like a rawhide whip that's just itching to get cracking."
VIDEO: 'Cowboys & Aliens': Behind the Scenes with Photographer Timothy White
"It's James Bond and Han Solo strapping on their six-shooters and taking on aliens, and if that's not one hell of an idea for a summer blockbuster, we don't know what is," champions Moviefone...before they blast the film for being "disappointingly familiar" and the cast "surprisingly forgettable."
"Daniel Craig gets it done when he's punching the tar out of people, but his turn as Jake Lonergan definitely doesn't rank with the likes of Eastwood and The Duke," they say.
STORY: 'Cowboys & Aliens' Invade 'Jimmy Kimmel Live'
Roger Ebert agrees with the familiarity of the role, but praises the actor for delivering a "high standard" performance in a role he was "more or less born into." The critic, who calls the film "the most cockamamie plot" he's seen in a long time, says "Craig cold-eyed and lean, plays a character familiar in the genre; think of the Ringo Kid or Doc Holliday, bad guys who rise to goodness."
The AP's David Germain blasts Craig's aloof characterization, saying he takes "the stony-faced lone rider thing to such stoic extremes it borders on blandness."
For his part, Craig told MTV that he focused a lot on his character's American accent, and intentionally kept his dialogue sparse. "I didn't want it to stand out -- I wanted it to sound as natural as possible," he said. "I cut as many lines as I could and got them down to one sentence or even one syllable sometimes."
Never miss a story. Stay up-to-date with THR's Daily Headlines.
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Paul Rudd and Marvel's Kevin Feige Reveal 'Ant-Man's' Saga, from Director Shuffle to Screenplay Surgery to Studio's "Phase Three" Plans
HBO's Real-Life Game of Thrones: The Fight to Stay Rich, on Top and Score Bill Simmons
Taraji P. Henson, Viola Davis and Drama Actress A-List Tackle Race, Sexism, Aging in Hollywood
Lena Dunham, Amy Schumer and Comedy Actress A-List in Raunchy, R-Rated Roundtable
Bob Odenkirk, David Oyelowo and Drama Actor A-List on Oscar Snubs, Bad Scripts and Getting Ignored by Robert Redford


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A little postcard like idea I had for the contact section. Still a lot of tweaking left but I like where this is going.
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E-Swab, Vitamin E GentleBright™Plus Lip Care Instructions for Use Light Activated Liquid Treatment INSIDE each cotton tip swab Single Patient Whitening Kit NET 1.8ml Item # 210064-P Moisturize and help protect lips. So unique, it's patented! Soft cotton tip swabs individually filled with Vitamin E lip care moisturizing formula. Complete Chairside Whitening, including a Take-Home Touch-up Kit DIRECTIONS: 1. Hold swab with the colored ring end up. Using the 2. Bend the colored ring tip gently to one side, until it "snaps", to release the liquid inside. Luma Whitening System 3. Liquid flows down into the white tip. 4. Apply liquid to lips, and then dispose. Use one before tooth whitening to Materials Included keep from drying out. Use one after the whitening procedure is completed to soften and smooth lips. In order of use Cotton Towel/Bib NOTE: Advise your patient that E-Swabs can be used twice a day to maintain Flour of pumice softness and help prevent fine lines and is available in a 72 pack from your dental Cheek retractor dealer. Braided cotton roll, 6" E-Swab Vitamin E lip & gum moisturizer (4 each) US Patent Protected GentleBright™Plus whitening material (dual-barrel syringe/w mixing tip) Aspirator Tip Teeth Whitening Shade Guide StayBright™Plus take-home whitening material Patient Take-Home Instruction sheet Additional Materials Required 1 pair Scissors 3% hydrogen peroxide (optional) 2830 Via Orange Way, Ste. B Gauze, several 2x2, dry Spring Valley, CA 91978 Toll Free 800-400-2262 The Procedure Phone 619-660-5410 NOTE: The material provided for this procedure is designed to lighten both upper Fax 619-660-5459 and lower arches simultaneously with increased whitening taking place for a number Made in the USA of days following the procedure. Lightening touch-ups can be performed on selected teeth only if needed. The light will not affect the untreated teeth in the absence of the lightening material. Crowns and bridges will not lighten with or be adversely affected by the lightening procedure. CAUTION: Mixture may discolor clothing. GentleBright™Plus protocol; rev 3 12/12/06 1) Remove the GentleBright™Plus dual-barrel syringe from package. Snap 20) Apply E-Swab Vitamin E lip & gum moisturizer (provided) to the upper and off the plastic cap covering the dispensing end. Attach the mixing tip to the lower gums. Remove the cheek retractor and apply the Vitamin E to the lips. dispensing end of the syringe and twist to lock in place. Make sure the tip is Determine the post-treatment shade with the provided Teeth Whitening Shade attached securely to the syringe bevel. Guide. 2) Determine the existing shade with the provided Teeth Whitening Shade Guide 21) Supply the patient with the StayBright™Plus take-home material and and note the pre-op upper and lower shade on the Shade Guide. Take a pre-op review the instructions on its proper use. Instruct the patient to begin the photo (optional). StayBright™Plus procedure that evening. Apply StayBright™Plus to 3) Place protective eyewear on patient. the teeth, following the "Instructions For Use" insert. If you wish, give the cheek 4) For tetracycline or A3.5 or darker shades, apply a 5-second acid etch to the teeth retractor to the patient for applying the StayBright™Plus at home. (optional). NOTE: It is important for the patient to complete the treatment by applying the 5) Use flour of pumice (included) to thoroughly clean the teeth, eliminate surface StayBright™Plus material starting after the in-office procedure. Instruct the stains, and remove pellicle/plaque layer. Do not use prophy gels or any patient that the lightening procedure continues throughout the use of the substances containing fluoride or glycerin, as this can interfere with the whitening process. Concentrate on yellow cervical areas of upper and lower StayBright™Plus to realize the full whitening potential. Have the patient teeth. If desired, the lingual areas can also be pumiced to remove stain and return a week following treatment for a follow-up examination and post shade provide a better overall result. Good preparation is the key to successful guide photo (Optional). Emphasize that the patient should avoid tobacco and results. teeth-staining type foods and beverages for at least 48 hours after the in-office 6) Insert cheek retractor. (included) (blue medium size provided, small tab keeps treatment, as teeth are especially vulnerable to staining during this period. the tongue away from the teeth) 7) Rinse and dry the teeth thoroughly. 8) Cut the 6" braided cotton roll in half than make a small cut in the middle of each, place in the vestibule of both the upper and lower arch with the small cut straddling the labial frenum. Warnings: 9) Apply E-Swab Vitamin E lip & gum moisturizer (provided) to the gums and lips, lower and upper. (See back page for instructions) 10) Inform the patient they could smell a slight chlorine or swimming pool type • Avoid contact with eyes. If product contacts the eye, flush immediately with smell; it's the activation of the material on the teeth. copious amounts of water for 15 minutes: consult physician if irritation or disturbance in vision occurs. 11) Dispense approximately 1/5 of the GentleBright™Plus material onto the • Should product cause a lasting noticeable skin reaction, flush with water for 15 teeth, both upper and lower arch, using a consistent coverage of 2-3mm thick, minutes and consult physician. including the cervical and incisal areas, ensuring the entire front tooth surface is covered. • If a substantial quantity is ingested, or in case of noticeable discomfort, drink 12) Insert a small saliva ejector into the patient's mouth to maintain a dry area water or milk and consult physician. (optional). 13) Set the patient in a semi-reclined position using the dental chair. 14) Position the Fullsmile Illuminator (head of the Luma unit) as close as possible to the surface of both arches to ensure complete coverage of the smile area. 15) Set the digital timer of the Luma system for 5 minutes. Start the first cycle. 16) When the audible alarm indicates the cycle is complete, the light will automatically turn off. 17) Once the cycle is completed remove the whitening material from the patient's teeth using suction (do not wet the teeth.) It is important to maintain a dry area. 18) Repeat steps 11-17 four more times for a total of five 5 minute cycles. 19) After the last cycle is completed, keep the cheek retractors in place, remove the whitening material from the teeth and rinse with suction and water to completely remove all the material for the mouth. GentleBright™Plus protocol; rev 3 12/12/06
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UPDATE IN COLON CANCER by: Gil Lederman, M. D. In a National Cancer Database report trends for variety of cancers especially the most common cancers. The data includes variations in stage or extent of disease as well as treatments implemented and overall survival. From 1985 through 1993, colon cancer data was evaluated including 36,937 patients in 1988 and 44, 812 in 1993. This is a project of the Commission on Cancer of the American College of Surgeons and the American Cancer Society. The goal is to evaluate cancer care outcome in America. Colon cancer is the fourth most common malignancy in adults and the second most common cause of cancer deaths. Treatment was analyzed by the stage or extent of disease. While 28% of the 1988 patients had no reported clinical or pathologic stage, only 9% of the 1993 cases were so unlabeled. This suggests improvement in cancer care. There were differences as well as similarities in patients who developed colon cancers. When analyzed for age, area of the country, sex, incidence, economic level or ethnic background, there were no discernible differences. However, in patients 80 years of age or older, the stage tended to be lower (less extensive disease) than in younger patients. Furthermore, black Americans were diagnosed at an earlier age than white Americans - with blacks being diagnosed on average at 66.4 years compared to 69.7 years for white Americans. Excluding African Americans, all other ethnic groups had similar stage of cancer at presentation. African Americans had the highest incidence of Stage IV disease - the most extensive amount of disease. African Americans averaged 25.4% of Stage IV disease compared to 17.9% to 19.9% in other ethnic groups. There was an increased incidence of right colon cancers in 1993 compared to 1988. This is a continuation of a previous trend on the right side of the bowel that has been long-standing. The grade of the tumor represents the aggressiveness as observed by the pathologist under the microscope. Sixty-four percent of Grade I - the lowest grade or the least aggressive cancer - were Stage I or II, the earliest stages of colon cancer. Thirty-five percent and 31% of Grade III or IV respectively were Stage I or II. Thus, the more aggressive the tumor under the microscope the more likely the tumor was to be a greater stage. Also, there was a relationship between the stage of disease and the location of the cancer. Sigmoid disease (located nearest the anus) had a likelihood of being Stage I in 25.6% of the cases while the ascending colon had only 19.4% of its primaries being early Stage I malignancies. Recently published data shows that adjuvant or additional therapy after surgery improves outcome for those with colon cancer. Those with Stage III colon cancer are the most likely to benefit with a resultant decreased lower recurrence rate and longer survival. According to data presented, 43% of patients received systemic or adjuvant chemotherapy. Chemotherapy was most commonly used in the Pacific area of the United States and least commonly in the Northeast area. Chemotherapy was also less likely to be used for patients older than 70 years of age where it was given in 18.6% of patients and only in 5% of patients older than 80 years. For patients under 50 years of age, 36.7% received chemotherapy. Additionally, small hospitals with less than 150 cases per year were less likely to administer chemotherapy than larger hospitals. Lower grade and distal site of the primary were associated with better outcomes, thought secondary to an earlier stage of cancer. Increasing age was noted to have a worse outcome by stage while sex and ethnic background did not. Low income adults had a 5 to 7% worse outcome than middle or higher income patients. This study authored by Jessup, et al and appearing in the journal CANCER found several important points. The first is that while patients younger than 50 years of age have more advanced cancers. The second point was that African Americans tend to have colon cancer at an earlier age than white Americans so increased vigilance may be most important for this group of high risk patients. The authors noted that staging systems to determine the extent of disease were better implemented in the later years. This would be a step toward improved treatment. Also emphasized was that the grade of the cancer is important in determining outcome of therapy. Adjuvant therapy clearly has increased in use being implemented in 7.2% of patients in 1985 but 22.3% in 1993. The impact of chemotherapy on survival most likely will be felt in subsequent years of analysis because of the short follow up rendered. The authors did note improvement in survival in Stage III patients receiving adjuvant therapy. Thus, this important demographic work should produce better care for patients and serve as a guideline for physicians caring for people with this highly common malignancy. Our group at Radiosurgery New York has pioneered stereotactic body radiosurgery, which allows for more precise than usual and higher dose than usual radiation. By utilizing this combination of precision and higher dose, we are able to treat recurrent colon cancers – even in the abdomen, pelvis, chest, liver or lymph nodes and have a high control rate in that treated area. It is an appealing option when more usual methods have failed to produce the desired outcome. Also, because of its precision, there is more relative protection of healthy tissues.
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Lin Ewen had never thought much about refugees, until living near two refugee families brought their plight home to her.
The dawn service is a fixture of our commemoration of Anzac Day, but there has been much debate and confusion about when it started.
Inspired by the Anzac spirit, artist Pamela Ruggera encourages viewers to explore the emotions of war through her surreal drawings.
As Albany marks 100 years since the departure of the first convoy we're inviting you to find out what the Anzac story means to people today.
Military heirlooms tell the stories of loved ones that went to war, and in some cases made the ultimate sacrifice.
A horse's hooves show the bond between a soldier and his horse during the First World War.
A POW remembers his time on a family farm in Broomehill.
A Japanese aircraft compass becomes a memento for a WW2 digger.
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A German prisoner of war transformed a shell case into a piece of art.
The story behind a rather intriguing sign once used regularly on the Albany Highway in southern WA.


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Raves: L.A. County Criticized on National Stage for its How-to-Take Ecstasy Campaign
An L.A County health department campaign that seeks to teach young people how to safety trip on ecstasy came under fire this week after Fox News picked up on the Weekly's story about the taxpayer-funded drug literature.
Jeffrey Reynolds, executive director of the Long Island Council on Alcoholism and Drug Dependence, told Fox the county was taking the wrong approach. He called the strategy "patently unsafe."
"You have to be careful of the message," he says. And what's that message?
The county advises ravers to "Aim low (dose AND frequency) ... Take frequent breaks ... Let your body cool and rest ... [and] Stay hydrated."
"There is no way to use ecstasy or any other substance like that safely. The reality is they're illegal drugs and come with significant health risks."
The targeted events for the health department's ecstasy fliers are countywide but specifically include four-times-a-year raves at the publicly-owned L.A. Coliseum and Sports Arena, where an strict 18-and-up policy has been instituted but remains an illusive goal. (The last event, Together As One on New Year's Eve at the Sports Arena, saw the ID-checking system break down).
"That [message] shouldn't be doled out to 14- and 16-year-old kids," Reynolds said. "The main message needs to be: 'You shouldn't be doing this and here's a way to get help."
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Primary Care Doctor, Family Practitioner
33 years of experience
33 years of experience
65 Water St
Blue Hill, ME 04614 Phone number & directions
Blue Hill, ME 04614 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Arthur Newkirk:
View the full profile to get information on:
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Patient Reviews
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Specialties & Research
Dr. Arthur Newkirk, MD is board certified in Family Medicine.
Education & Awards
Dr. Newkirk graduated from Upstate Medical University Physical Medicine and Rehabilitation, Syracuse. He has 1 awards.
Dr. Newkirk has 2 hospital affiliations:
- Blue Hill Memorial Hospital
- Eastern Maine Medical Center
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4 years experience
Blue Hill, ME
- Additional Information
- Dr. Arthur Doring Newkirk MD is a male Family Practitioner, has 33 years of experience and practices in Family Medicine.
- Where does Dr. Arthur D. Newkirk practice?
- Dr. Arthur Newkirk has 1 office location.
Dr. Arthur Newkirk practices Family Medicine near Blue Hill, ME.
See Blue Hill Primary Care Doctors.


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By Rachel Gordon on Tuesday 1st November 2005
Jack (Michael Caine) has recently died, leaving in his wake a widow, two children, and three close friends. His last wish is that lifelong companions Vic (Tom Courtenay), Lenny (David Hemmings), and Ray (Bob Hoskins) throw him out to sea at the honeymoon spot he shared with wife Amy (Helen Mirren). His son, Vince (Ray Winstone), joins them.
On the long drive out, each reflects and shares various life-changing experiences they had with Jack, which are seen in flashback. Intelligently, writer/director Schepisi chooses distinctive experiences to look back on. These are suavely detailed so that you know what is important to learn from that moment but don't become annoyed with the choices you know are about to occur. For instance, Vince is obviously going to have had difficult issues with his father during adolescence because that's normal. But the familial dynamic between Jack and Vince allows for their interaction to feel spontaneous, even though we've heard these arguments a thousand times in other films.
Unfortunately, like so many movies centered on the British working class, it can be hard to understand characters because the dialect is so heavy. Of course, this adds to the realism of camaraderie, but it defeats the purpose of explaining key emotional growths. You have to rely on facial expressions, and sometimes this doesn't work when certain "secrets" are forced into focus.
The other disadvantage to Last Orders is that the pacing appears solely based on Ray's history with Jack. True, he's not the only one who flashes to past events, but he is in almost every scene, the others thrown in for spice. If the whole film had been just about the friendship between Jack and Ray, this would have sufficed. There's almost no reason to have the others, though they do give fine performances.
This effects the pacing, which can get muddy in the time line a particular flashback. Besides, when there are separate actors for "old" and "young," with the added touch of a toupee for Hoskins, there are no emotional stepping stones to climb in the process of personal exploration provoked by the loss of a loved one.
Last Orders is a rare gem of acting and thematic perception. The cast ably pulls off the affectionate jocularity of a group that has stood many of life's tests together, and the human penchant for fault is easy to relate to. Maybe if some of the more powerful moments were stretched across several sudden realizations instead of being forced to fit a memory box, the plot would have held up to its courageous crew.
Last order: steak, rare.
Year: 2001
Run time: 109 mins
In Theaters: Friday 11th January 2002
Box Office USA: $2.2M
Distributed by: Sony Pictures Classics
Production compaines: winchester films, Future Films, MBP (Germany), Scala Productions
Contactmusic.com: 3.5 / 5
Rotten Tomatoes: 79%
Fresh: 70 Rotten: 19
Director: Fred Schepisi
Producer: Fred Schepisi, Elisabeth Robinson
Screenwriter: Fred Schepisi
Starring: Michael Caine as Jack, Tom Courtenay as Vic, David Hemmings as Lenny, Bob Hoskins as Ray, Helen Mirren as Amy, Ray Winstone as Vince, J. J. Feild as Young Jack, Cameron Fitch as Young Vic, Nolan Hemmings as Young Lenny, Anatol Yusef as Young Ray, Kelly Reilly as Young Amy, Stephen McCole as Young Vince, George Innes as Bernie, George Innes as June, Sally Hurst as Mandy
Also starring: Fred Schepisi, Elisabeth Robinson


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Flying with little kids is rarely straightforward, but long flights -- especially transcontinental flights -- pose a special challenge. Local writer Evelyn Shoop recently traveled overseas with her family, so I asked her to share her best tips with … [Read more]
Book Love: Better Than Before by Gretchen Rubin
My next Book Love is Better Than Before: Mastering the Habits of Our Everyday Lives, by Gretchen Rubin. I'm reasonably confident you already know Gretchen because her previous book, The Happiness Project, sits on so many peoples' shelves. I … [Read more]
6 satisfying meals to cook with a hotel coffeemaker or iron
This post is sponsored by Embassy Suites. I love traveling with my kids, especially now that they can walk, eat, and go to the bathroom by themselves. But even when they were little we traveled every year -- as much as time and budget … [Read more]
I've had a lightbulb moment about my kids' picky eating
I've been frustrated by my kids' picky eating for years. But I think I've had an epiphany. I just remembered how my appetite changed while I was pregnant. I, who had never been picky, suddenly became intensely opinionated about my food. I … [Read more]
Book Love: Design Mom by Gabrielle Blair
My first official Book Love is Gabrielle Blair's Design Mom: How to Live With Kids: A Room By-Room Guide. A surprising choice because I'm an ambivalent homemaker, a so-so decorator and a habitual underbuyer. (Fortunately I married a domestically … [Read more]
Introducing Book Love
You know how, when you're thinking about buying a new car, you suddenly notice that exact car all over town? It's sort of like that for me right now with books. Now that I'm writing another book, I find myself tuned in to other authors. … [Read more]
Consequences vs. Punishment: How They're Different and Why It Matters
How is giving kids consequences different from punishing them? Let's be honest: isn't a "consequence" really just a politically-correct term for "punishment?" To some parents, yes. But here's how I see the (often subtle) distinction between … [Read more]
My five favorite hacks for Easter
While I'm away on Spring Break with my family, I thought I'd leave you with something fun for the leadup to Easter: my five favorite Easter hacks. I gave these archive gems a little 2015 makeover. 1. Dye Easter eggs in a muffin tin Leah's Easter … [Read more]
An online learning challenge that reveals real buried treasure…and a $10K scholarship [Discount Code]
This post is sponsored by Brain Chase, a summer learning challenge like nothing I've ever seen before. Read on for details, plus a special discount code for Parent Hacks readers. I've long held that "summer brain drain" is an academic problem, … [Read more]
Chores for Older Kids: Hold Them Accountable
We've had a breakthrough with my kids' chores. Not because we discovered a magical new chore system for older kids -- but because we finally held our kids accountable to the chore system we're already using. Chores for Older Kids: Expect More As … [Read more]


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World Briefing | Europe: Germany: Inquiry Into Conservatives Dropped
By Victor Homola (NYT)
Published: January 4, 2002
Prosecutors in Munich dropped an inquiry into the Bavaria-based Christian Social Union, the sister party to the conservative Christian Democrats, the country's main opposition party. They said there were no grounds to investigate a report in the magazine Stern that said that the party had improperly obtained federal matching funds by counting subscriptions to party newspapers as donations. The senior prosecutor, Horst Lehmpuhl, said the practice had been approved by Parliament. Party officials said the accusations were part of a smear campaign against the party leader, Edmund Stoiber, who is a leading candidate to run for chancellor in September. Victor Homola (NYT)


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Washdown Shaft Collars Help Protect Equipment from ContaminationOctober 24, 2013 3:41 pm | by MDT Staff | Product Releases | Comments
Washdown shaft collars from Ruland help protect hygienic equipment from bacterial contamination. Washdown shaft collars feature a patent pending assembly containing a type 303 stainless steel shaft collar, a two-piece housing made from FDA compliant materials, and three O-rings with NSF H1 registered lubricant.LISTED UNDER: Cleaning Supplies | Assembly Equipment
Wet/Dry Vacuums Provide Versatile and Cost-Efficient PerformanceOctober 24, 2013 3:19 pm | by MDT Staff | Product Releases | Comments
Advance introduces the new VL500 Wet/Dry Vacuums, designed to provide a flexible, reliable cleaning solution for both wet and dry applications. Featuring a superior filtration system, easy-to-use functions and multiple accessories, the VL500 series satisfies diverse cleaning challenges, ranging from small office environments to large education and healthcare facilities.LISTED UNDER: Vacuums
Cylindrical Grinding MachineOctober 11, 2013 3:24 pm | by MDT Staff | Product Releases | Comments
Jones and Shipman has introduced their new Suprema 1000M cylindrical grinding machine with productivity enhancements not found in their current 1000mm machine. Jones and Shipman's "self teach" easy touch screen has been upgraded to a Fanuc Power motion.LISTED UNDER: Grinding Machines
Safety Light CurtainOctober 11, 2013 3:16 pm | by MDT Staff | Product Releases | Comments
Keyence has introduced their new GL-S safety light curtain. This exciting addition to the GL series offers a versatile solution for applications where space constraints are a major factor. The GL-S also provides increased ease of use and simplified installation compared to conventional safety light curtains.LISTED UNDER: Assembly Equipment | Production Tools
3D Design Capability to all Engineers with Mechanical Software ToolSeptember 16, 2013 5:09 pm | by MDT Staff | Product Releases | Comments
Allied Electronics (Allied) and RS Components (RS) has announced a significant development in the history of 3D design software with the unveiling of DesignSpark Mechanical, a new 3D solid modeling and assembly tool that is available to all – totally free of charge.LISTED UNDER: 3D Modeling
New Class II, Type A2 Biological Safety CabinetsSeptember 13, 2013 4:13 pm | by MDT Staff | Product Releases | Comments
Air Science has introduced its NEW line of Biological Safety Cabinets. The Purair BIO is designed to protect individuals, the environment, and products from a variety of biological particulates, serving as the primary barrier in life science research and experimentation.LISTED UNDER: Curtains/Dividers | Fume Hood | Furniture
Can Be Used for Safeguarding as Well as for HousekeepingSeptember 12, 2013 3:35 pm | by MDT Staff | Product Releases | Comments
Danray Products is offering free-standing shields that can be used in many applications for safeguarding as well as for housekeeping. Ideal for lathes and milling machines, these shields can be applied between machines, on the backside of machines, and along aisles.LISTED UNDER: Curtains/Dividers
Standalone DFX Validation SolutionSeptember 6, 2013 4:40 pm | by MDT Staff | Product Releases | Comments
Geometric Limited has announced the launch of Geometric DFX, a standalone application for carrying out DFX validation of product designs. Geometric DFX is powered by Geometric's award-winning design for manufacturability solution DFMPro and leverages the CGM 3D modeling kernel from Spatial Corp...LISTED UNDER: 3D Modeling | Product Design & MFG Software | Validation Software
750OF Electric Class 100 Cleanroom OvenAugust 21, 2013 3:50 pm | by MDT Staff | Product Releases | Comments
No. 836 is a 750OF electrically-heated Class 100 cleanroom oven from Grieve, currently used to bake various coatings onto products at a customer's facility. Workspace dimensions of this oven measure 36" wide x 36" deep x 39" high.LISTED UNDER: Cleanroom Ovens
New Multi-Tasking Robot PlatformAugust 14, 2013 5:29 pm | by MDT Staff | Product Releases | Comments
Fisnar has announced the launch of a new multi-tasking robot model F9960N for safe and secure dispensing applications ranging from miniature SMT circuit boards to larger PCB's and finished assemblies.LISTED UNDER: Robotic Systems
New Spot-Curing System Features Enhanced Unit Status and Notification DisplaysAugust 14, 2013 3:51 pm | by MDT Staff | Product Releases | Comments
Dymax Corporation has released a new spot-curing system, the BlueWave 200 version 3.0, which offers the highest intensity and most user-friendly operation in the industry. The automatic, controlled power-up sequence ensures proper lamp operating temperature to minimize scrap...LISTED UNDER: Adhesive-Curing Systems
Two-part Adhesive Dispenser Provides High Accuracy Using Bulk MaterialsAugust 12, 2013 3:42 pm | by MDT Staff | Product Releases | Comments
A new, pneumatic tabletop adhesive dispenser for two-part adhesives that is simple to refill and operate, has foot pedal control, and accurate piston metering has been introduced by Ashby Cross Company of Newburyport, MA.LISTED UNDER: Adhesive Dispensers
Strong, Improved Delta Robot Handles up to 100 Cycles Per MinuteAugust 9, 2013 5:45 pm | by MDT Staff | Product Releases | Comments
ABB Robotics has added an 8 kg model to its IRB 360 FlexPicker line, supplementing the existing 1 kg and 3 kg models and expanding the high speed picking and packing performance of the most widely used Delta robot in the industry to heavier items.LISTED UNDER: Robotic Systems
3D Inspection Profiling for Parts MeasurementJuly 31, 2013 8:03 pm | by MDT Staff | Heidenhain Corp. | Product Releases | Comments
Offering a new 3D Profiling capability to inspection measurement, Heidenhain's versatile IK 5000 QUADRA-CHEK PC software system now gives operators the ability to quickly measure and determine parts profiles within desired tolerance zones.LISTED UNDER: Production Software | Measurement Instruments
New Mobile Ductless Fume HoodsJuly 30, 2013 7:55 pm | by MDT Staff | Product Releases | Comments
The Mobile EDU is excellent for Classroom Demonstrations and Industrial Training. It is totally self-contained and provides all around visibility. The EDU is easily moved from laboratory to laboratory. The Ductless Design allows easy installation and the base is mounted on large heavy-duty wheels for ease of transport.LISTED UNDER: Fume Hood


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Publications (16)45.5 Total impact
- SourceAvailable from: Irena Loryan
Conference Paper: Estimation of unbound drug cerebral exposure using a merging approach of in vitro and in vivo assaysINTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY; 06/2012
Article: Application of a Loading Dose of Colistin Methanesulfonate in Critically Ill Patients: Population Pharmacokinetics, Protein Binding, and Prediction of Bacterial Kill[Show abstract] [Hide abstract]
ABSTRACT: A previous pharmacokinetic study on dosing of colistin methanesulfonate (CMS) at 240 mg (3 million units [MU]) every 8 h indicated that colistin has a long half-life, resulting in insufficient concentrations for the first 12 to 48 h after initiation of treatment. A loading dose would therefore be beneficial. The aim of this study was to evaluate CMS and colistin pharmacokinetics following a 480-mg (6-MU) loading dose in critically ill patients and to explore the bacterial kill following the use of different dosing regimens obtained by predictions from a pharmacokinetic-pharmacodynamic model developed from an in vitro study on Pseudomonas aeruginosa. The unbound fractions of colistin A and colistin B were determined using equilibrium dialysis and considered in the predictions. Ten critically ill patients (6 males; mean age, 54 years; mean creatinine clearance, 82 ml/min) with infections caused by multidrug-resistant Gram-negative bacteria were enrolled in the study. The pharmacokinetic data collected after the first and eighth doses were analyzed simultaneously with the data from the previous study (total, 28 patients) in the NONMEM program. For CMS, a two-compartment model best described the pharmacokinetics, and the half-lives of the two phases were estimated to be 0.026 and 2.2 h, respectively. For colistin, a one-compartment model was sufficient and the estimated half-life was 18.5 h. The unbound fractions of colistin in the patients were 26 to 41% at clinical concentrations. Colistin A, but not colistin B, had a concentration-dependent binding. The predictions suggested that the time to 3-log-unit bacterial kill for a 480-mg loading dose was reduced to half of that for the dose of 240 mg.Antimicrobial Agents and Chemotherapy 05/2012; 56(8):4241-9. DOI:10.1128/AAC.06426-11 · 4.45 Impact Factor
Article: Quantitative analysis of the opioid peptide DAMGO in rat plasma and microdialysis samples using liquid chromatography-tandem mass spectrometry[Show abstract] [Hide abstract]
ABSTRACT: A liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method for the quantification of the opioid peptide DAMGO in rat plasma, as well as DAMGO and the microdialysis recovery calibrator [(13)C(2),(15)N]-DAMGO in microdialysis samples, is described. The microdialysis samples consisted of 15 μL Ringer solution containing 0.5% bovine serum albumin. Pretreatment of the samples involved protein precipitation with acetonitrile followed by dilution with 0.01% formic acid. The lower limits of quantification were 0.52 ng/mL and 0.24 ng/mL for DAMGO and [(13)C(2),(15)N]-DAMGO respectively and the response was linear up to 5000 fold higher concentrations. The plasma samples (50 μL) were precipitated with acetonitrile containing the isotope labeled analog [(13)C(2),(15)N]-DAMGO as internal standard. The method was linear in the range of 11-110,000 ng/mL. The separations were conducted on a HyPurity C18 column, 50×4.6 mm, 3 μm particle size, with a mobile phase consisting of acetonitrile, water and formic acid to the proportions of 17.5:82.5:0.01. Low energy collision dissociation tandem mass spectrometric (CID-MS/MS) analysis was carried out in the positive ion mode using multiple reaction monitoring (MRM) of the following mass transitions: m/z 514.2→453.2 for DAMGO and m/z 517.2→456.2 for [(13)C(2),(15)N]-DAMGO. The intra-day precision and accuracy did not exceed 5.2% and 93-104% for both compounds and sample types described. The inter-day precision an accuracy were <6.8% and 95-105% respectively. The method described is simple, reproducible and suitable for the analysis of small sample volumes at low concentrations.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 05/2012; 900:11-7. DOI:10.1016/j.jchromb.2012.05.014 · 2.69 Impact Factor
Article: Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo[Show abstract] [Hide abstract]
ABSTRACT: Diphenhydramine (DPHM) and oxycodone are weak bases that are able to form cations. Both drugs show active uptake at the blood-brain barrier (BBB). There is thus a possibility for a pharmacokinetic interaction between them by competition for the same uptake transport system. The experiments of the present study were designed to study the transport of DPHM across the BBB and its interaction with oxycodone in vitro and in vivo. In vitro, the interaction between the drugs was studied using conditionally immortalized rat brain capillary endothelial cells (TR-BBB13 cells). The in vivo relevance of the in vitro findings was studied in rats using brain and blood microdialysis. DPHM was actively transported across the BBB in vitro (TR-BBB13 cells). Oxycodone competitively inhibited DPHM uptake with a K(i) value of 106 μM. DPHM also competitively inhibited oxycodone uptake with a K(i) value of 34.7 μM. In rats, DPHM showed fivefold higher unbound concentration in brain interstitial fluid (ISF) than in blood, confirming a net active uptake. There was no significant interaction between DPHM and oxycodone in vivo. This accords with the results of the in vitro experiments because the unbound plasma concentrations that could be attained in vivo, without causing adverse effects, were far below the K(i) values.Journal of Pharmaceutical Sciences 09/2011; 100(9):3912-23. DOI:10.1002/jps.22567 · 3.01 Impact Factor
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ABSTRACT: Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 1 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 microg/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 microg/ml but increased in the presence of meningitis (approximately 0.5 microg/ml or 34 to 67% of serum levels).Antimicrobial Agents and Chemotherapy 09/2010; 54(9):3985-7. DOI:10.1128/AAC.01799-09 · 4.45 Impact Factor
Article: Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS[Show abstract] [Hide abstract]
ABSTRACT: An analytical method for quantitation of colistin A and colistin B in plasma and culture medium is described. After protein precipitation with acetonitrile (ACN) containing 0.1% trifluoroacetic acid (TFA), the supernatants were diluted with 0.03% TFA. The compounds were separated on an Ultrasphere C18 column, 4.6 mm x 250 mm, 5 microm particle size with a mobile phase consisting of 25% ACN in 0.03% TFA and detected with tandem mass spectrometry. The instrument was operating in ESI negative ion mode and the precursor-product ion pairs were m/z 1167.7-->1079.6 for colistin A and m/z 1153.7-->1065.6 for colistin B. The lower limit of quantification (LLOQ) for 100 microL plasma was 19.4 and 10.5 ng/mL for colistin A and B, respectively, with CV <6.2% and accuracy <+/-12.6%. For culture medium (50 microL+50 microL plasma), LLOQ was 24.2 and 13.2 ng/mL for colistin A and B, respectively, with CV <11.4% and accuracy <+/-8.1%. The quick sample work-up method allows for determination of colistin A and B in clinical samples without causing hydrolysis of the prodrug colistin methanesulfonate (CMS).Journal of pharmaceutical and biomedical analysis 12/2008; 49(3):760-7. DOI:10.1016/j.jpba.2008.12.016 · 2.83 Impact Factor
Conference Paper: Population Pharmacokinetic Analysis of Colistin After Intravenous Administration in Critically Ill Patients With Gram Negative Infections[Show abstract] [Hide abstract]
ABSTRACT: Background: Colistin is used in infections by multi-drug resistant gram negative bacteria (MDR-GNB) but pharmacokinetic data are limited. It is administered intravenously in the form of colistimethate sodium (CMS) that is hydrolyzed in vivo to colistin. The pharmacokinetics of CMS and colistin in a population of critically ill was studied. Methods: Patients receiving colistin for infection by MDR-GNB were enrolled, excluding those on renal replacement. CMS was administered at a dose of 3 MU (240 mg) q8h. Venous blood was collected immediately before and at multiple occasions after the first and fourth infusion. Plasma CMS and colistin concentrations were determined with a novel LC-MS/MS method after a rapid precipitation step that avoids significant degradation of CMS and colistin. Population pharmacokinetic analysis was performed in NONMEM. The CMS and colistin data were modeled simultaneously and the formation rate of colistin was governed by the elimination rate of CMS. Results: Eighteen patients (6 female, mean age 63.6 years, mean creatinine clearance 82.3 ml/min) were included. For CMS a 2-compartment model best described the pharmacokinetics with the half-lives of the two phases estimated to 0.24 h and 2.7 h, respectively. Clearance of CMS was 20.1 L/h. For colistin a 1-compartment model was sufficient to describe the data with an estimated half-life of 21.1 h. Predicted colistin Cmax at steady state was 2.81 mg/L. CL/fm was 10.2 L/h and Vd/fm was 311 L for colistin. The estimated between patient variability (CV) in CL and CL/fm were 40% and 84% for CMS and colistin, respectively. Conclusions: Colistin displays significantly long half life in relation to the dosing interval. The implications include insufficient plasma concentrations before steady state, raising the question of the benefit of a loading dose.Infectious Diseases Society of America 2008 Annual Meeting; 10/2008
Article: Population pharmacokinetics of nevirapine in combination with rifampicin-based short course chemotherapy in HIV- and tuberculosis-infected South African patients.[Show abstract] [Hide abstract]
ABSTRACT: The aim was to develop a model to describe the population pharmacokinetics of nevirapine in South African human immunodeficiency virus (HIV)-infected patients who were taking nevirapine-based antiretroviral therapy concomitantly or in the absence of rifampicin-based tuberculosis therapy. Patients were divided into two groups: (1) patients receiving nevirapine-containing antiretroviral regimen (200 mg twice daily) and continuation phase rifampicin-containing tuberculosis therapy (n = 27) in whom blood samples were obtained before and not less than 14 days after they completed tuberculosis therapy; (2) patients without tuberculosis who were receiving a nevirapine-containing antiretroviral regimen for at least 3 weeks (n = 26). The population pharmacokinetics of nevirapine was described using nonlinear mixed effects modelling with NONMEM software. Based on the developed model, plasma concentration profiles after 300, 400 and 500 mg of nevirapine twice daily were simulated. Concomitant administration of rifampicin increased nevirapine oral clearance (CL/F) by 37.4% and reduced the absorption rate constant (k(a)) by almost sixfold. Rifampicin reduced the nevirapine average minimum concentration by 39%. Simulated doses of 300 mg twice daily elevated nevirapine concentrations above subtherapeutic levels in most patients, with minimum exposure above the recommended maximum concentration. The area under the concentration-time curve of 12-hydroxynevirapine was not different in the presence of rifampicin. 2-, 3- and 8-Hydroxynevirapine were not detectable (LLOQ = 0.025 mg/L). The developed model adequately describes nevirapine population pharmacokinetics in a South African population when taken with/and in the absence of rifampicin treatment. The simulations suggest that an increased dose of 300 mg twice daily would achieve adequate nevirapine concentrations in most patients during rifampicin-containing treatment for tuberculosis.European Journal of Clinical Pharmacology 09/2008; 65(1):71-80. DOI:10.1007/s00228-008-0481-y · 2.70 Impact Factor
Article: Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to investigate which principal human cytochrome P450 (CYP450) enzymes are affected by artemisinin and to what degree the artemisinin derivatives differ with respect to their respective induction and inhibition capacity. Seventy-five healthy adults were randomized to receive therapeutic oral doses of artemisinin, dihydroartemisinin, arteether, artemether or artesunate for 5 days (days 1-5). A six-drug cocktail consisting of caffeine, coumarin, mephenytoin, metoprolol, chlorzoxazone and midazolam was administered orally on days -6, 1, 5 and 10 to assess the activities of CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP2E1 and CYP3A, respectively. Four-hour plasma concentrations of parent drugs and corresponding metabolites and 7-hydroxycoumarin urine concentrations were quantified by liquid chromatography-tandem mass spectrometry. The 1-hydroxymidazolam/midazolam 4-h plasma concentration ratio (CYP3A) was increased on day 5 by artemisinin [2.66-fold (98.75% CI: 2.10-3.36)], artemether [1.54 (1.14-2.09)] and dihydroartemisinin [1.25 (1.06-1.47)] compared with day -6. The S-4'-hydroxymephenytoin/S-mephenytoin ratio (CYP2C19) was increased on day 5 by artemisinin [1.69 (1.47-1.94)] and arteether [1.33 (1.15-1.55)] compared with day -6. The paraxanthine/caffeine ratio (CYP1A2) was decreased on day 1 after administration of artemisinin [0.27 (0.18-0.39)], arteether [0.70 (0.55-0.89)] and dihydroartemisinin [0.73 (0.59-0.90)] compared with day -6. The alpha-hydroxymetoprolol/metoprolol ratio (CYP2D6) was lower on day 1 compared with day -6 in the artemisinin [0.82 (0.70-0.96)] and dihydroartemisinin [0.83 (0.71-0.96)] groups, respectively. In the artemisinin-treated subjects this decrease was followed by a 1.34-fold (1.14-1.58) increase from day 1 to day 5. These results show that intake of artemisinin antimalarials affect the activities of several principal human drug metabolizing CYP450 enzymes. Even though not significant in all treatment groups, changes in the individual metrics were of the same direction for all the artemisinin drugs, suggesting a class effect that needs to be considered in the development of new artemisinin derivatives and combination treatments of malaria.Fundamental and Clinical Pharmacology 07/2007; 21(3):307-16. DOI:10.1111/j.1472-8206.2007.00471.x · 2.08 Impact Factor
Article: Enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4′-hydroxymephenytoin in human plasma and urine by liquid chromatography/tandem mass spectrometry[Show abstract] [Hide abstract]
ABSTRACT: A sensitive method using enantiospecific liquid chromatography/tandem mass spectrometry detection for the quantitation of S- and R-mephenytoin as well as its metabolites S- and R-nirvanol and S- and R-4'-hydroxymephenytoin in plasma and urine has been developed and validated. Plasma samples were prepared by protein precipitation with acetonitrile, while urine samples were diluted twice with the mobile phase before injection. The analytes were then separated on a chiral alpha(1)-acid glycoprotein (AGP) column and thereafter detected, using electrospray ionization tandem mass spectrometry. In plasma, the lower limit of quantification (LLOQ) was 1 ng/mL for S- and R-4'-hydroxymephenytoin and S-nirvanol and 3 ng/mL for R-nirvanol and S- and R-mephenytoin. In urine, the LLOQ was 3 ng/mL for all compounds. Resulting plasma and urine intra-day precision values (CV) were <12.4% and <6.4%, respectively, while plasma and urine accuracy values were 87.2-108.3% and 98.9-104.8% of the nominal values, respectively. The method was validated for plasma in the concentration ranges 1-500 ng/mL for S- and R-4'-hydroxymephenytoin, 1-1000 ng/mL for S-nirvanol, and 3-1500 ng/mL for R-nirvanol and S- and R-mephenytoin. The validated concentration range in urine was 3-5000 ng/mL for all compounds. By using this method, the metabolic activities of two human drug-metabolizing enzymes, cytochrome P450 (CYP) 2C19 and CYP2B6, were simultaneously characterized.Rapid Communications in Mass Spectrometry 02/2006; 20(3):463-72. DOI:10.1002/rcm.2324 · 2.64 Impact Factor
Article: On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry[Show abstract] [Hide abstract]
ABSTRACT: A sensitive and reproducible method for the determination of morphine and the metabolites morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) was developed. The method was validated for perfusion fluid used in microdialysis as well as for sheep and human plasma. A C18 guard column was used to desalt the samples before analytical separation on a ZIC HILIC (hydrophilic interaction chromatography) column and detection with tandem mass spectrometry (MS/MS). The mobile phases were 0.05% trifluoroacetic acid (TFA) for desalting and acetonitrile/5 mM ammonium acetate (70:30) for separation. Microdialysis samples (5 microL) were directly injected onto the system. The lower limits of quantification (LLOQ) for morphine, M3G and M6G were 0.50, 0.22 and 0.55 ng/mL, respectively, and the method was linear from LLOQ to 200 ng/mL. For plasma, a volume of 100 microL was precipitated with acetonitrile containing internal standards (deuterated morphine and metabolites). The supernatant was evaporated and reconstituted in 0.05% TFA before the desalting process. The LLOQs for sheep plasma were 2.0 and 3.1 ng/mL and the ranges were 2.0-2000 and 3.1-3100 ng/mL for morphine and M3G, respectively. For human plasma, the LLOQs were 0.78, 1.49 and 0.53 ng/mL and the ranges were 0.78-500, 1.49-1000 and 0.53-500 ng/mL for morphine, M3G and M6G, respectively.Rapid Communications in Mass Spectrometry 08/2005; 19(15):2116-22. DOI:10.1002/rcm.2035 · 2.64 Impact Factor
Article: Quantitative determination of cetirizine enantiomers in guinea pig plasma, brain tissue and microdialysis samples using liquid chromatography/tandem mass spectrometry[Show abstract] [Hide abstract]
ABSTRACT: Sensitive enantioselective liquid chromatographic assays using tandem mass spectrometric detection were developed and validated for the determination of S-cetirizine (S-CZE) and R-cetirizine (R-CZE) in guinea pig plasma, brain tissue, and microdialysis samples. Enantioselective separation was achieved on an alpha1-acid glycoprotein column within 14 min for all methods. A cetirizine analog, ucb 20028, was used as internal standard. Cetirizine and the internal standard were detected by multiple reaction monitoring using transitions m/z 389.1 --> 200.9 and 396.1 --> 276.1, respectively. The samples were prepared using protein precipitation with acetonitrile. For guinea pig plasma, the assay was linear over the range 0.25-5000 ng/mL for both S-CZE and R-CZE, with a lower limit of quantification (LLOQ) of 0.25 ng/mL. For the brain tissue and microdialysis samples, the assays were linear over the range 2.5-250 ng/g and 0.25-50 ng/mL, respectively, and the LLOQ values were 2.5 ng/g and 0.25 ng/mL, respectively. The intra- and inter-day precision values were < or =7.1% and < or =12.6%, respectively, and the intra- and inter-day accuracy varied by less than +/-8.0% and +/-6.0% of the nominal value, respectively, for both enantiomers in all the matrices investigated.Rapid Communications in Mass Spectrometry 06/2005; 19(12):1749-57. DOI:10.1002/rcm.1983 · 2.64 Impact Factor
Article: Determination of cefuroxime in human serum or plasma by liquid chromatography with electrospray tandem mass spectrometry[Show abstract] [Hide abstract]
ABSTRACT: Cefuroxime is a second-generation cephalosporin used against different kinds of bacterial infections. To be able to optimize the dosing it is necessary to characterize the pharmacokinetics of cefuroxime which requires a selective and sensitive analytical method for cefuroxime in plasma or serum. A new rapid liquid chromatography/electrospray tandem mass spectrometry (LC/MS/MS) method, using cefotaxime as internal standard, was developed for analysis of cefuroxime in human serum. The work-up procedure consisted of protein precipitation with acetonitrile/cefotaxime, and after centrifugation the supernatant was dissolved in mobile phase. The sample was injected on a SB-CN column and the detection was performed using tandem mass spectrometry (MS/MS). The limit of quantification was determined to 0.025 microg/mL. The method was linear in the range 0.025-50 microg/mL with a coefficient of correlation >0.999. The limit of quantification and intra-day variability were found to be the same for plasma samples, which indicates that the method is valid for serum as well as plasma samples.Rapid Communications in Mass Spectrometry 03/2004; 18(6):707-10. DOI:10.1002/rcm.1396 · 2.64 Impact Factor
Article: The use of liquid chromatography/mass spectrometry for quantitative analysis of oxycodone, oxymorphone and noroxycodone in Ringer solution, rat plasma and rat brain tissue.[Show abstract] [Hide abstract]
ABSTRACT: Sensitive and reproducible methods for the determination of oxycodone, oxymorphone and noroxycodone in Ringer solution, rat plasma and rat brain tissue by liquid chromatography/mass spectrometry are described. Deuterated analogs of the substances were used as internal standards. Samples in Ringer solution were analyzed by direct injection of 10 microL Ringer solution diluted by an equal volume of water. The limit of quantification was 0.5 ng/mL and the method was linear in the range of 0.5-150 ng/mL for all substances. To analyze oxycodone and oxymorphone in rat plasma, 50 microL of plasma were precipitated with acetonitrile, and the supernatant was directly injected onto the column. To analyze oxycodone, oxymorphone and noroxycodone in rat plasma, 100 microL of rat plasma were subjected to a C18 solid-phase extraction (SPE) procedure, before reconstituting in mobile phase and injection onto the column. For both methods the limit of quantification in rat plasma was 0.5 ng/mL and the methods were linear in the range of 0.5-250 ng/mL for all substances. To analyze the content of oxycodone, oxymorphone and noroxycodone in rat brain tissue, 100 microL of the brain homogenate supernatant were subjected to a C18 SPE procedure. The limit of quantification of oxycodone was 20 ng/g brain, and for oxymorphone and noroxycodone 4 ng/g brain, and the method was linear in the range of 20-1000 ng/g brain for oxycodone and 4-1000 ng/g brain for oxymorphone and noroxycodone. All methods utilized a mobile phase of 5 mM ammonium acetate in 45% acetonitrile, and a SB-CN column was used for separation. The total run time of all methods was 9 min. The intra-day precision and accuracy were <11.3% and <+/-14.9%, respectively, and the inter-day precision and accuracy were <14.9% and <+/-6.5%, respectively, for all the concentrations and matrices described.Rapid Communications in Mass Spectrometry 01/2004; 18(21):2565-76. DOI:10.1002/rcm.1658 · 2.64 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Our goal was to investigate whether artemisinin autoinduction is caused by an increase in cytochrome P450 (CYP) 2B6 or CYP2C9 activities, we evaluated the effects of multiple-dose artemisinin administration on S-mephenytoin N-demethylation in healthy subjects. Fourteen subjects, 6 poor metabolizers of CYP2C19 and 8 extensive metabolizers, received a single oral dose of 200 mg racemic mephenytoin (CYP2B6 in vivo marker) before (day -28) and during multiple-dose artemisinin administration (250 mg/d orally for 9 days and 500 mg on the tenth day). A 500-mg single dose of artemisinin was administered on day -28. The CYP2C9 in vivo marker tolbutamide was administered on day -28 and on days 7, 12, and 17 to monitor the minor involvement of CYP2C9 in S-mephenytoin N-demethylation. Artemisinin oral clearance increased 5.3-fold (P <.001) by the tenth day of administration. Its pharmacokinetics was not different in the 2 CYP2C19 phenotypes. The oral clearance of R-mephenytoin increased 1.7-fold (P <.05) in both phenotypes during the period of artemisinin administration. The area under the concentration-time curve ratio of S-nirvanol/S-mephenytoin, an index of CYP2B6 activity, increased 1.9-fold (P <.05) in CYP2C19 poor metabolizers during artemisinin multiple-dose administration, whereas the urinary excretion ratio of hydroxytolbutamide plus carboxytolbutamide/tolbutamide remained constant during the study period. These results indicate that artemisinin induces the N-demethylation of S-mephenytoin probably by an increased capacity of CYP2B6. The autoinduction phenomenon of artemisinin may, therefore, be attributed, at least in part, to induction of CYP2B6, because this is the isozyme primarily involved in its metabolism. In addition, artemisinin alters the disposition of R-mephenytoin by an unidentified isozyme.Clinical Pharmacology & Therapeutics 08/2003; 74(1):32-43. DOI:10.1016/S0009-9236(03)00092-4 · 7.39 Impact Factor
Article: Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4 '-hydroxymephenytoin in human plasma by liquid chromatography[Show abstract] [Hide abstract]
ABSTRACT: A high-performance liquid chromatographic method for the enantiospecific quantitation of S- and R-mephenytoin and its metabolites S- and R-nirvanol and S- and R-4'-hydroxymephenytoin in plasma is described. The compounds were separated using a reversed-phase C(2) column in tandem with a chiral alpha(1)-acid glycoprotein column and were detected using ultraviolet detection at 205 nm. The lower limit of quantification was 10 ng/ml for all compounds using 0.5 ml human plasma (intra-day coefficient of variation <13%, accuracy <+/-20%). The method was validated for human plasma in the concentration range 10-2000 ng/ml for each of the six compounds. The method allows for the simultaneous characterisation of the metabolic capacity of two human drug-metabolising enzymes, CYP2C19 and CYP2B6, and may be used when investigating polymorphisms or changes in activity of these two enzymes.Journal of Chromatography B 07/2003; 791(1-2):179-91. DOI:10.1016/S1570-0232(03)00221-6 · 2.69 Impact Factor
Top Journals
Uppsala University
Uppsala, Uppsala, Sweden
- Department of Pharmaceutical Biosciences


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Mich. cop attacked, dragged before shooting suspect in pursuit
As the officer started to place the suspect under arrest, he began fighting the cop and reentered his vehicle – dragging the officer for a few feet as he sped off.
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text: Severn Bridge Upcycled Tea Towel Cushion by Hunted and Stuffed £50$104.66€72.65$81.37 In stock £33.00$69.07€47.95$53.70 delivery to United States - Receive this item 5-10 working days from dispatch International delivery available quantity by Hunted and Stuffed Location: London, GB read seller's profile see seller's complete range more items from this seller Sail Away Nautical Cushion £80$167.45€116.24$130.19 Upcycled Vintage Sik Brocade Wedding Kimon... £275$575.63€399.60$447.53 Upcycled Vintage Coffee Apron £30$62.79€43.59$48.82 Victorian Love Tea Towel Sailing Ship £14$29.30€20.34$22.78 Upcycled Vintage Grand National Cushion £50$104.66€72.65$81.37 Tartan Cushion The Duke Upcycled Vintage G... £95$198.85€138.04$154.60 view all you may also like PRODUCT DETAILS DELIVERY RETURNS Made in Britain eco-friendly ask seller a question save for later A vibrant up-cycled tea towel cushion featuring the Severn Bridge connecting England and Wales. Handmade by repurposing a vintage tea towel. A great gift for those who appreciate architectural design and engineering, have connections with England and Wales or the river Severn, or who love original vintage textiles and want to own something unique that's been handmade with love in the UK. Throw it on the sofa to create a cool vintage or even industrial look. This cushion is one of a kind, only one made, only one will ever be made. We have only made one of these so this is the only one available. A truly unique cushion. made from: Handmade using an original vintage tea towel with colours so fresh it looks brand new. Finished on the reverse with lovely luxury grey wool, the inside is fully over locked for strength and fastens with an original vintage brass anchor button. Comes with a British-made luxury feather and down pad included. We carefully clean all vintage textiles before up-cycling them. You can remove the cover for cleaning easily. Dry cleaning recommended. dimensions: H70 X W45 X D10cm product code: 246463 This product is dispatched to you by Hunted and Stuffed. MAINLAND UK order now and receive this item on or before price Free Delivery Wednesday 8 July FREEFREEFREEFREE Two Day Delivery Tuesday 7 July £3.95$8.26€5.73$6.42 Express Next Day 1pm Monday 6 July £6.95$14.54€10.09$11.31 Saturday Delivery Saturday 4 July £12.95$27.10€18.81$21.07 NON-MAINLAND UK estimated delivery price Highlands & Islands of Scotland 2-5 working daysfrom dispatch £4.75$9.94€6.90$7.73 Northern Ireland 2-5 working daysfrom dispatch £4.75$9.94€6.90$7.73 Other UK Islands 2-5 working daysfrom dispatch £4.95$10.36€7.19$8.05 INTERNATIONAL DELIVERY estimated delivery price Western Europe 2-5 working daysfrom dispatch £20.00$41.86€29.06$32.54 Rest of Europe 5-10 working daysfrom dispatch £20.00$41.86€29.06$32.54 USA & Canada 5-10 working daysfrom dispatch £33.00$69.07€47.95$53.70 Far East & Australasia 5-10 working daysfrom dispatch £38.00$79.54€55.21$61.84 Rest of the world 5-14 working daysfrom dispatch £38.00$79.54€55.21$61.84 You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Hunted and Stuffed's return policy


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Arrange 3 red, 3 blue and 3 yellow counters into a three-by-three square grid, so that there is only one of each colour in every row and every column
Jack has nine tiles. He put them together to make a square so that two tiles of the same colour were not beside each other. Can you find another way to do it?
Use the clues to work out which cities Mohamed, Sheng, Tanya and
Bharat live in.
These activities focus on finding all possible solutions so if you work in a systematic way, you won't leave any out.
These activities lend themselves to systematic working in the sense that it helps if you have an ordered approach.
These activities focus on finding all possible solutions so working in a systematic way will ensure none are left out.
Start with three pairs of socks. Now mix them up so that no
mismatched pair is the same as another mismatched pair. Is there
more than one way to do it?
If these elves wear a different outfit every day for as many days
as possible, how many days can their fun last?
Explore the different snakes that can be made using 5 cubes.
Make a pair of cubes that can be moved to show all the days of the
month from the 1st to the 31st.
How many different shapes can you make by putting four right-
angled isosceles triangles together?
In a bowl there are 4 Chocolates, 3 Jellies and 5 Mints. Find a way
to share the sweets between the three children so they each get the
kind they like. Is there more than one way to do it?
El Crico the cricket has to cross a square patio to get home. He
can jump the length of one tile, two tiles and three tiles. Can you
find a path that would get El Crico home in three jumps?
Lorenzie was packing his bag for a school trip. He packed four
shirts and three pairs of pants. "I will be able to have a
different outfit each day", he said. How many days will Lorenzie be
Moira is late for school. What is the shortest route she can take from the school gates to the entrance?
These activities lend themselves to systematic working in the sense that it helps to have an ordered approach.
My coat has three buttons. How many ways can you find to do up all
the buttons?
Frances and Rishi were given a bag of lollies. They shared them out evenly and had one left over. How many lollies could there have been in the bag?
Imagine that the puzzle pieces of a jigsaw are roughly a
rectangular shape and all the same size. How many different puzzle
pieces could there be?
Place eight dots on this diagram, so that there are only two dots
on each straight line and only two dots on each circle.
Seven friends went to a fun fair with lots of scary rides. They
decided to pair up for rides until each friend had ridden once with
each of the others. What was the total number rides?
Can you find out in which order the children are standing in this
How could you put eight beanbags in the hoops so that there are
four in the blue hoop, five in the red and six in the yellow? Can
you find all the ways of doing this?
Use the information to describe these marbles. What colours must be
on marbles that sparkle when rolling but are dark inside?
Place eight queens on an chessboard (an 8 by 8 grid) so that none
can capture any of the others.
Put 10 counters in a row. Find a way to arrange the counters into
five pairs, evenly spaced in a row, in just 5 moves, using the
The Red Express Train usually has five red carriages. How many ways
can you find to add two blue carriages?
These are the faces of Will, Lil, Bill, Phil and Jill. Use the clues to work out which name goes with each face.
Take three differently coloured blocks - maybe red, yellow and blue. Make a tower using one of each colour. How many different towers can you make?
These eleven shapes each stand for a different number. Can you use the multiplication sums to work out what they are?
In this maze of hexagons, you start in the centre at 0. The next
hexagon must be a multiple of 2 and the next a multiple of 5. What
are the possible paths you could take?
Chandra, Jane, Terry and Harry ordered their lunches from the
sandwich shop. Use the information below to find out who ordered
each sandwich.
In Sam and Jill's garden there are two sorts of ladybirds with 7 spots or 4 spots. What numbers of total spots can you make?
My briefcase has a three-number combination lock, but I have
forgotten the combination. I remember that there's a 3, a 5 and an
8. How many possible combinations are there to try?
The brown frog and green frog want to swap places without getting
wet. They can hop onto a lily pad next to them, or hop over each
other. How could they do it?
Use the clues to find out who's who in the family, to fill in the family tree and to find out which of the family members are mathematicians and which are not.
Place the numbers 1 to 8 in the circles so that no consecutive
numbers are joined by a line.
George and Jim want to buy a chocolate bar. George needs 2p more
and Jim need 50p more to buy it. How much is the chocolate bar?
Using the cards 2, 4, 6, 8, +, - and =, what number statements can
you make?
Tim had nine cards each with a different number from 1 to 9 on it.
How could he have put them into three piles so that the total in
each pile was 15?
Can you help the children find the two triangles which have the
lengths of two sides numerically equal to their areas?
On a digital clock showing 24 hour time, over a whole day, how many
times does a 5 appear? Is it the same number for a 12 hour clock
over a whole day?
Investigate the different ways you could split up these rooms so
that you have double the number.
You cannot choose a selection of ice cream flavours that includes
totally what someone has already chosen. Have a go and find all the
different ways in which seven children can have ice cream.
Nina must cook some pasta for 15 minutes but she only has a 7-minute sand-timer and an 11-minute sand-timer. How can she use these timers to measure exactly 15 minutes?
What do you notice about the date 03.06.09? Or 08.01.09? This
challenge invites you to investigate some interesting dates
Look carefully at the numbers. What do you notice? Can you make
another square using the numbers 1 to 16, that displays the same
Suppose we allow ourselves to use three numbers less than 10 and
multiply them together. How many different products can you find?
How do you know you've got them all?
Use your logical-thinking skills to deduce how much Dan's crisps and ice-cream cost altogether.


text:
Кирилл Кисселев о том как клубы относятся к аналитической статистике в НХЛ
City 3-1 Sunderland | SAMIR ON GOAL | Nasri reaction
Samir Nasri talks to CityTV about the wonder goals in the Capital One Cup final Subscribe for FREE and never miss another CityTV video. http://www.youtube.com/subscription_center?add_user=mcfcofficial Register with City to receive even more official con
Glenn Robinson III Hits Game-Winner vs. Purdue
Michigan's Glenn Robinson III beats his father's alma mater with a last second bucket off the glass.
KEVIN HART VISITS CITY | City Today 26 February
In today's episode Kevin Hart meets the Manchester City players, and scores a penalty past Joe Hart. We also see Nasri talking about the Capital One Final. Subscribe for FREE and never miss another CityTV video. http://www.youtube.com/subscription_cente
MESSI v RONALDO - decided by girls
Lionel Messi v Cristiano Ronaldo - it's the debate that has dominated modern football. It's been analysed from every angle expect one. Now, the fairer sex decided once and for all who wins between two of the greatest players of all time... Subscribe: htt
YAYA ON BARCELONA | Champions City v Barca Yaya Toure press conference
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ESPN FC: From London to Toronto
Shaka Hislop discusses the Brazilian National team and Queens Park Rangers goalie Julio Cesar joining Toronto FC on loan.
ESPN FC: Can Liverpool overcome the odds?
Special guest Mikael Silvestre gives this thoughts on Liverpool's Premier League title chances.
Dion Waiters Serves Up a Spin Move and Reverse Layup
Dion Waiters spins into the lane and throws up the reverse layup for the excellent circus play. Visit nba.com/video for more highlights. About the NBA: The NBA is the premier professional basketball league in the United States and Canada. The league is
TFC Media Day: Bradley Orr
Bradley Orr sits down with Paul Hendrick and Adrian Serioux of GOL TV Canada, to discuss the upcoming season.
Servicemen and family reunited at Bruins game
A servicemen surprises his family by coming home a week earlier than expected at the Bruins game on 2/8/14.
George Hill's CLUTCH Game-Tying Three Pointer
With under ten seconds to play, George Hill knocks down the three to tie the Pacers and Blazers at 103. The Pacers would go on to win 118-113 in OT. Visit nba.com/video for more highlights. About the NBA: The NBA is the premier professional basketball l
Andrew Wiggins nails halfcourt buzzer-beater #SCtop10
Andrew Wiggins was held scoreless in the first half until burying this last second heave for the Jayhawks.
INSIDE CITY 107 Yaya Toure can't stop scoring free kicks!
Fresh from his duel with Fernandinho (check it out here - http://www.youtube.com/watch?v=9QSxLLTMbsw&list=UUkzCjdRMrW2vXLx8mvPVLdQ&feature=share&index=10) Yaya Toure continues to score free kicks! Subscribe for FREE and never miss another CityTV video. h
ESPN FC: Sturridge in the wrong?
Is there something wrong with going for the glory? Shaka Hislop discusses Daniel Sturridge vs Everton.
Maurice Edu: 'I feel like I'm home again'
Hear from Maurice Edu following his presentation as Philadelphia Union's new Designated Player. Credit for Image: Greg Carroccio/Sideline Photos.
Mike Adams - Stuffed Animals & GI Joe #MediaDayQuestions
Mike Adams tells us whether he owned a stuffed animal as a kid. Uh, he didn't.
FREE KICKS Yaya v Fernandinho | Training at Manchester City
Watch as Fernandinho and Yaya Toure go head to head during training at Carrington. Who takes the better free kick? Let us know in the comments below! Subscribe for FREE and never miss another CityTV video. http://www.youtube.com/subscription_center?add_u
TFC Training Camp: Michael Bradley
Michael Bradley speaks to the media at TFC training camp in Florida.
TFC Training Camp: Bradley Orr
Bradley Orr speaks with the media at the start of training camp on Monday.
ESPN FC: One of the great debates
FC's Shaka Hislop and Steve Nicol discuss Maradona's remarks about Pele being "second-best" to himself.


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Arizona Aloha Festival 2014
Sunday, March 9, 2014 | 1 year ago
This weekend, Tempe Beach Park is filled with food, music, dancing, and jewelry celebrating the cultures of the Pacific Islands at the Arizona Aloha Festival.
Marking its 20th anniversary, there was no shortage of good food, refreshing sweets, and long lines at the event Saturday. Read the full recap of Arizona Aloha Festival 2014 here.
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We found 6 sites within 15 miles of Beaumont-cum-Moze with 3 bookable
Clacton-on-Sea, Essex, England Show on map
|Single-axle mixed touring caravan pitch - optional electric
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Clacton-on-Sea, Essex, England Show on map
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Fen Farm Caravan and Camping Site
Colchester, Essex, England Show on map
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|From £18/€25.02/AU$34.51/$26.86/25.84Fr per night
Ipswich, Suffolk, England Show on map
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Steadings Park Camping and Caravan Site
Woodbridge, Suffolk, England Show on map
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Join the Dana-Thomas House Foundation as they host their annual summer gala, "Jazz in Bloom" on Saturday, July 25, 2015 from 6-9 pm. The magnificent Frank Lloyd Wright-designed courtyard will be filled with great Jazz music by the Sam Crain Trio as guests enjoy delicious food and beverages and a truly fabulous silent/live auction. The event is $60 per person and includes all food and beverages. Reservations may be made online at dana-thomas.org.
Image via dana-thomas.org


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Key things you need to know aboutDr. Derhartounian:
Dr. Derhartounian's Experience
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Dr. Derhartounian's Specialties
- Dentistry
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Procedures Dr. Derhartounian Performs
- Composite Fillings
- Dental Bonding
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Conditions Dr. Derhartounian Treats
- Cavity
- Gingivitis
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Likelihood of recommending Dr. Derhartounian to family and friends is 2.5 out of 5 5 1 8
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Accepting new patients?
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- Flintridge Dental Studio
- Flintridge Dental Studio
- 4542 Rinetti Ln
- La Canada Flintridge, CA 91011
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The key to a successful appointment is communication. To get the most out of your visit, prepare ahead of time so you can lead the conversation with your doctor. These 7 tips will get you ready
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