text:
Steve Jobs Admired Mark Zuckerberg
The Apple CEO expressed admiration for the young Facebook founder
By: Ashley Baylen
Walter Isaacson, author of the internationally bestselling biography entitled "Steve Jobs", discussed the late Apple CEO's admiration for Mark Zuckerberg at a recent event with Facebook board member, Don Graham of the Washington Post.
"I once asked Jobs who he admired in Silicon Valley… Mark's was the first name of his lips," Isaacson said.
Isaacson went on to explain that Jobs' admiration for the young CEO was partly due to his "intuitive feel" for the social network he created.
According to Business Insider, Isaacson shared that Jobs "felt an odd kinship to Mark" and appreciated Zuckerberg's passion and willingness to "do stuff that allows him to be on shifting sands- his willing to cannibalize old things."
Additionally, Issacson remarked that Jobs never pursued social media after his failed Ping effort "because Mark did it so well."
"There's not a need for a whole lot of social networks, and Facebook has got it licked," Jobs told Isaacson.
Spock Documentary Acquires Sufficient FundingJuly 02, 2015 | By Daina Goldfinger
The film has reached funding of $600,000
North Carolina Man Waves Nazi FlagJuly 02, 2015 | By Daina Goldfinger
The male does not see an issue with the swastika-labeled flag
Google Mistakenly Labels Black People as GorillasJuly 02, 2015 | By Daina Goldfinger
The automatic image labeling service made an offensive mistake
Amy Winehouse was on the Brink of Making a Third Album Before She DiedJuly 02, 2015 | By Daina Goldfinger
The demos that Winehouse had recorded were destroyed by her producer
Israeli Rehabilitation Program Pairs Prisoners with the DisabledJuly 01, 2015 | By Abigail Klein Leichman
An award-winning program pairs Israeli prisoners with severely disabled residents of ALEH Negev, benefiting both partners and, ultimately, society
Israeli Artist Draws Obama, Clinton, & Other Politicians as HipstersJuly 01, 2015 | By Viva Sarah Press
Amit Shimoni is the artist behind HIPSTORY and SHEPSTORY, depicting world leaders as hipsters
Hapoel Jerusalem Wins First Championship Game, Apparently Thanks to Their New StadiumJuly 01, 2015 | By B. Shane Morganstein
Team owner credits unlikely championship to building of brand new 10,000 seat arena
Study: Anti-Semitism is on the Decline in EuropeJuly 01, 2015 | By B. Shane Morganstein
A new ADL poll finds anti-Semitism down among general populations, but on the rise among Western European Muslims
The Ten Most Famous Jewish Porn Stars Culture » Society » News


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I'm taking a java class and the instructor has had us build a HashMap like this:
Map<String, SortedSet<Car>> makeSetMap = new HashMap<String, SortedSet<Car>>();
The Car objects are read in from a file of cars (like
Toyota Corolla 8 90000) and do some processing to get them into the Hashmap as described above. So the map's key is a string which ends up being a manufacturer name (Toyota) and then the values are SortedSet of Cars.
Later in the app i'm supposed to set it up so a user can select which model he wants to have displayed and then it will display just car data that are from that model. Right now I'm just stuck on figuring how to access all the data in the whole thing. I've written some code for the Hashmap and I can get the Manufacturer names to display with an iterator, but I can't figure out how to display the individual car data. :(
Here's what I have so far - it's a snippet, but I think you guys can figure it out:
//I'm starting to have trouble here..
Set<String> brands = makeSetMap.keySet();
System.out.println("Brands are: " + brands.toString());
Iterator<String> brandsIt = brands.iterator();
while (brandsIt.hasNext())
SortedSet<Car> brandmodels;
//brandmodels = brandsIt.next();
//System.out.println("Working on: " +brandmodels.toString());
Help! Thanks to anyone who can straighten me out.

subset: commoncrawl


text:
Trustworthy reviews are our priority. Businesses can't pay to change or remove reviews.
Robert was amazing from our first meeting through to our wedding day. His calm dimeanor and friendly attitude was much appreciated on such a hectic day. He listened to what we wanted and delivered. I absolutely loved working with Robert and we absolutely love our engagement and wedding photos. I'd absolutely recommend him. He is a natural artist who is passionate about what he does.
Robert photographed our wedding and he is awesome. There really is no other word I would use to describe him or his work. He is fast, efficient and above all his work is gorgeous! He truly has an artistic eye and respects his craft. He will capture the beauty in every moment, expression and happening. We couldn't be more pleased with our photos. It sounds cliché, but looking at our photographs really was like reliving the day all over again...and it was a good day. Worth every penny.
I would highly recommend Robert to any couple looking for sophisticated and modern wedding photography. My fiancé and I were initially concerned with some of the cheesy-ness and over-the top posing of many wedding shots we had reviewed. Being New Yorkers, we wanted something a little more on trend and artistic but yet elegant and timeless. Robert's pictures are exactly that. His pictures are absolutely stunning. He was a delight to work with and put us at ease immediately. He was genuinely concerned about our vision for the wedding photography and made sure that we had the chance to take all the pictures we had discussed despite weather and time pressures. He managed to capture our personalities and candid moments, rather than forcing the bridal party into awkward forced poses. I cannot recommend Robert enough.
From my initial phone conversation with Rob, I knew he was our guy. He was extremely professional yet personable from the start and we couldn't be happier with the quality of the pictures and the overall value of job he did for us. Rob captured every moment of our special day beautifully, yet you hardly knew he was there. I would definitely recommend Rob to all my friends and look forward to working with him again in the future.
I simply can't say enough about Robert as our wedding photographer. He was very easy to work with, amenable to our every request, and brilliant at capturing each moment. On the day of the wedding I hardly knew he was there, yet, when spotting a moment on the dance floor or in a speech, he was already snapping the photo.
I am FLOORED by our pictures. I have absolutely no idea how one man was in so many places at once. Our ceremony coverage looks like it was covered from 3 different angles and I can't recall ever even seeing him during it. His biggest strength is in capturing the candids. Although we absolutely loved our posed photos, the pictures of people caught in beautiful moments of laughter, hugs, dancing, and goofiness are where he really shines. His photos become a flip book of your event. You feel like you are truly reliving the feeling of each of them.
His hard work was evident when we saw him at the end of the night. He was soaked through his clothes with sweat and still beaming from ear to ear telling us what a wonderful time he had. That's just a quality of service that money can't buy. We are so grateful to have found him for our most special day. I can't imagine anyone else going to such lengths for complete strangers.
From the first night we met Robert my husband & I automatically made the decision to use Robert as our wedding photographer, in fact we hired him on the spot before even interviewing any other photographers. We were immediately drawn in by his enthusiasm, passion, and professionalism. It was clear from the beginning just how much Rob loves what he does, it was obvious after seeing his portfolio and even more so after meeting with him and hearing him talk about his experiences as a wedding photographer. Rob was super easy to work with, he went out of his way from day one to visit our venue on several different occasions to really get a feel for it prior to the wedding. He even attended our rehearsal all the way in NJ the night before the wedding, just to ensure that everything would be perfect the day of. And that it truly was...not only did Rob manage to capture all the magical moments of our amazing night, but he did it effortlessly and unintrusively. He made sure we got to spend a couple of minutes at our cocktail hour instead of taking pictures the entire time, and still managed to capture beautiful portraits in less than an hour! He also had our pics ready in less than 2 months from our wedding, and we couldn't be happier with the end result. We wholeheartedly recommend Rob for any event & had so much fun having him shoot our wedding!!!!!
I had an instant gut feeling about Robert when I looked at his site and saw the kind of work he did - very cool and natural, nothing too cheesy, just good photography in a classic, timeless style. He was very easy to talk with and discuss the wedding & very responsive always. On the actual day he was every part there when he needed to be, gave good direction when needed, and left the right moments alone. He was a welcome addition to the best day of my life (so far!) He even sent me some pictures ahead of time as my Father's birthday was soon after our wedding and I wanted to frame a picture for him for it. Professional and friendly - a great photographer and human all around (and with great turnaround!)
My husband and I had Robert take photos for both our Save the Date and our wedding. My husband was a little nervous, he did not think being followed around with a camera would be fun however, after our save the date pictures, he told me that it felt more like hanging out with a friend than staged photos. Everything just felt so natural with Robert. On our wedding day, guests commented on how professional and thorough he was. I have already recommended Robert to my friends who are now planning weddings. We love our wedding pictures SO much. Robert also has a unique style with his photography which we love, it makes our photos stand out. We hope to work with Robert in the future to capture other special events in our life.
After researching numerous photographers (too many to count), we finally found Robert and I'm so glad we did! From day 1 we had such a great experience working with him. We were able to meet with him prior to booking and he immediately put us at ease - he was open to all of our thoughts of what we were looking for, he was very genuine and up front about his work, and most importantly he was someone we both felt comfortable hanging out with. He was always very easy to get in touch with and quick to respond. The day of the wedding Robert and his 2nd shooter, Jen, were so attentive, professional, unobtrusive... and fun! We had such a great time working with both of them throughout the day and it shows in our photos. Robert has a great eye and was able to find beautiful, unique back drops for our portraits and he caught all of the natural moments of us and our guests. We received the edited photos back very quick considering the time and effort and that is put into post production. Overall, it was such an easy, collaborative, and fun process. Robert and Jen captured our day beautifully and for that we are so thankful.
Robert was extremely reachable, ultimate professional, and just an awesome person. Oh, and the photos, absolutely stunning! If you want the best, you've found the right photographer.
Robert was an absolute joy to work with. From the moment we contacted him he was easy going and accommodating. His passion for his craft is inspiring and he executes it with professionalism and perfection. His value is beyond his rate, the photos will speak for themselves. Our photos are art and went beyond a pretty backdrop and pose, with Robert behind the lense you can be sure these photos will evoke emotion. He is like a photography ninja capturing all the unnoticed details and moments of the day without ever getting in the way. When we received the photos we were so over joyed by the moments we missed. Robert also listened carefully to what we wanted like pictures of our beautiful son. He is open to all suggestions. Overall we are so happy we hired robert and without hesitation would recommend his services to everyone looking for an exceptional photographer.
Robert was absolutely fantastic from beginning to end. He was organized, professional, timely and super easy to work with. Robert captured every single smile, laugh, dance and much more so beautifully. He blended into the occasion and at times I barely knew he was even there! His photos are unique and stunning and beyond that, he has an awesome personality that meshed perfectly with ours. I would recommend Robert in a heartbeat!
We were so happy with the work Robert did with us at our wedding this past weekend. Since we are only a couple days removed, we haven't seen the full results yet. However, from the couple shots Robert couldn't resist showing us on his camera, we are so very excited to see what he came up with.
Robert's calm and enthusiastic demeanor was exactly what we needed to feel great about our day. We felt like we were in great hands all day and had a terrific time shooting with him as well. He went out of his way to make sure we got the shots we wanted, and several we had no idea we wanted - but are so glad we didn't miss the opportunity.
Robert also worked incredibly efficiently. We got through the formal family shots quickly which gave us extra time to explore the grounds and find more incredible shots. He was also very inconspicuous though out the ceremony and reception. Neither one of us were aware of him at all during the ceremony - although we have no doubt that we'll be well covered once we get to see the images. We were also thrilled to learn that Robert had experience shooting dance. He did not shy away from shooting movement, and as a result captured some really amazing moments.
Obviously, we highly recommend Robert if you're looking for a photo-journalistic style. He will shoot you interacting as a couple and let your personalities and energies drive the shoot. What better way to capture who you really are?
There is not enough stars to give this guy. Robert Carlo covered our wedding from start to end. He became our support team. He is extremely professional and has a passion for photography. He gave us so much more then we asked for both in time, number of photos and kindness. His pictures are unique and capture the moments' emotions. His portfolio speaks for itself, but I have to add that the photos are fantastic. We love our wedding pictures. We couldn't be happier with Rob. Thank you for your great work and passion for photography.
Anooshé & Pascal
I really tried to think of one thing that Robert Carlo could have improved on and I couldn't think of 1 thing. I am thankful that he was willing to travel to Los Angeles to grab our special day. We loved his wedding photos and completely filled when we saw his landscaping portraits. You pick a venue because you love it. He managed to capture us and the venue equally in the same shot. We are more than pleased with his professionalism and quality. There were moments he captured that I didn't think he was even around for, completely amazed!
Robert is creative and effective, instructive without being intrusive... everything you want in an event photographer. He was referred to me by the officiant who was performing our elopement ceremony and was extremely helpful in throwing together a ceremony for two in less than ten days! Our photos are fantastic! We look happy and relaxed - you can actually see how we were feeling! Couldn't ask for more!


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Back to the savings future?
Mar 20, 2012
Saving on an installment plan.
Is automated publishing the future?
Mar 20, 2012
Real books and bookstores are becoming a thing of the past. Does new technology mean authors are next to go?
Remembering the Encyclopedia Britannica
Mar 14, 2012
The paper version of the encyclopedia was killed off by its publisher yesterday, in order to focus on its digital editions.
Facebook: The Book
Feb 21, 2012
But printed on Facebook: The Site
Apple to introduce "Garage Band for books" on Thursday?
Jan 17, 2012
We can all be indie publishers
Investment book
Jan 9, 2012
On our local NPR station, WFYI, a guest Saturday morning on Marketplace Money recommended an investment advice book to a young caller. We can't recall the title of the book. Know which one we mean? Thanks in advance, Tom, Indianapolis, IN
Barnes & Noble could spin off the Nook
Jan 5, 2012
The company's e-reader has been a big success, while the rest of Barnes & Noble's business is suffering.
Got the Roth IRA: Now what?
Dec 30, 2011
I'm 25. After listening to your show, I decided, Hey, I ought to start saving for retirement, so I opened a Roth IRA. Now my question is: Is that it? Do I just put money in there and it grows? Or is this the type of thing where, once it's created, I then have to allocate the money in there to various investments? If it's the latter, what the HECK should I direct my first investments toward? Love the show, cheers! Sam, Concord, NH
The disappearing book
Dec 27, 2011
You'll see a lot of top ten lists this week, including one for books. But are those page turners about to vanish?
Not all "Books for Charity" go to charity
Dec 13, 2011
For-profit book recycler behind popular donation program sells many of the books received.


text:
Windover offers a lifestyle of comfort convenience - check out our walk score ! 1 2 bedroom garden apartments or 2 3 bedroom townhomes. Windover boasts tree lined streets with walking trails, Parquet foyers, French doors with transoms, gourmet kitchens with self-cleaning ovens, full service resident business center with high speed internet access, state-of-the art fitness center, resort inspired swimming pool, and two lighted tennis courts. We invite you to tour Knoxville's most elegant apartment interiors.
Sunday: 1:00 PM to 5:00 PM
Monday: 9:00 AM to 6:00 PM
Tuesday: 9:00 AM to 6:00 PM
Wednesday: 9:00 AM to 6:00 PM
Thursday: 9:00 AM to 6:00 PM
Friday: 9:00 AM to 6:00 PM
Saturday: 10:00 AM to 5:00 PM
|School Level
|Primary School
|Bearden Elementary School
|High School
|Bearden High School
|High School
|West High School
|This listing is priced
|Zip Code
|5% less than
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|Woodland Acres Apartments for Rent
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|High School
|8% more than
|Apartments for Rent near Bearden High School
|Unified School District
|5% more than
|Apartments for Rent near Knox County School District


text:
Pronunciation: psychochirurgie
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Global cooling is here
The Dodge County News
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Global cooling is here
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Wednesday, October 9. 2013
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Global cooling has arrived: Wyoming and South Dakota are experiencing heavy snow, shutting down Interstate highways for miles in both states. This is an unusually large snowfall for so early in October. It makes one wonder what winter will be like when it arrives. Of course, weather "experts" predicted in 1970 that we were headed for an Ice Age, even in summertime.
From Wild Bill on TheoSpark.net:
"Why should we trust government with the most important things in life! They can't even run the Post Office."
In the first two days of Obamacare in October, exactly zero Louisianans enrolled in the program. Yes, not one person in the state has enrolled in the new program. In Maryland in the same time period, fewer than 100 people enrolled. Source: ConservativeByte.com.
Several years back, West Virginia's liberal Democrat Senator Jay Rockefeller claimed Barack Obama was the president he had been waiting for all his life. That's how far left he is - just one more wealthy, out of touch liberal elitist who knows what's good for us. He is retiring next year. Good for West Virginia. That state has a lot of "hereditary" Democrats. Many vote Democrat by habit, a bad habit to cultivate.
"Politics is the conspiracy of the unproductive but organized against the productive but unorganized."
Joseph Sobran Sobran.com
The Reagan Museum in Simi Valley, California, about 40 miles north of Los Angeles, is staying open during the government shutdown.
"You know you are old when waitresses call you 'dear'."
Thomas Sowell TSowell.com
Remember South Carolina's former governor Mark Sanford running for his old Congressional seat in the May 7, 2013 special election? The national Republican party "experts" announced it would not help fund his campaign because of his personal indiscretions. They were willing to cede the seat to a liberal Democrat, just as they walked away from two almost sure Senate wins in Indiana and Missouri, effectively donating both Senate seats to the Democrats. Keep the actions of these fools in mind next time they contact you for a donation. Send money instead to the candidates, rather than the Republican Party, which cares almost as little as the Democrats about you. Could you imagine the elites in the Demoleft Party standing up to the many embarrassing loser candidates in their party and ever walk away from any of them? I can't.
Mark Sanford, with no help from the national Republican Party, won anyway. The people of his Congressional District did the right thing and sent him back to the House. Writer Scott Conroy on April 20, 2013, just 17 days before Mark Sanford won easily on May 7, wrote ominously: "Sanford was a slight favorite over Colbert Busch when the general election campaign began in the GOP - leaning district, but his chances of retaking the seat he held from 1995 to 2001 may be slipping away." Actually, it was the Democrat who saw her chances slipping away.
Imagine anyone being as out of touch as this writer, who underestimated the political savvy of South Carolina voters. Despite the huge influx of cash by the Democrats, they couldn't overcome the realization that a flawed Mark Sanford trumped a liberal Democrat any time.
New York Congressman Peter King and other Republican "moderates" do not like the new breed of Republicans conservatives. King says he's tired of conservatives in the party. Recently left-wing New York Senator Democrat Chucky Schumer advised Republicans to get rid of conservatives. It seems that the Republican Party in-crowd has a lot in common with Schumer.
Former Congressman Ron Paul's toll-free message number is 1-888-322-1414. You can read his weekly column at Free-Foundation.org.
Good websites: AMAC.us, Galganov.com, TheBlaze.com, GOPtheDailyDose.com, CapitolHillDaily.com, PoliticalOutcast.com, GeorgiaDogs.com, FatJewishGuy.com, JewishWorldReview.com, MaryGrabar.com, LewRockwell.com, VDare.com, CanadaFreePress.com, CowboyByte.com, HFontova.com, WeaselZippers.us, ColoradoGuy.com, MRC.org, PolitiChiks.tv, LibertyUnbound.com, OliverNorth.com, TincupCo.com, GhostTowns.com, BrianWilson.net, GoColorado.com, SisterToldjah.com, MrSEC.com, TheACRU.org, NetRightDaily.com. No need to capitalize.
Bumper sticker of the day: My Takehome Pay Won't Take Me Home.
My e-mail address is firstname.lastname@example.com.
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Christina McHugh
Laureen Marian Bird Helms
Tue, Jun 30, 2015 - 11:32 PM
My mother was a wonderful person inside and out, I'm completely great full for all the love and support to our fam [...]
County removes penalties, interest for Mosquito Creek Properties
Mon, Jun 29, 2015 - 09:17 PM
Dodge grand jury returns indictments
Fri, Jun 26, 2015 - 09:40 PM
I agree. Sending them to rsat is bs. All they do is take selfies with other dope addicts and laugh at the system.
Dixie Dan
Parade held
Fri, Jun 26, 2015 - 01:02 PM
Maybe Battle wasn't the old man beating a dead horse that you thought he was. He was easy to dismiss when that was [...]
Dodge grand jury returns indictments
Thu, Jun 25, 2015 - 03:29 PM
Omg, Penney you are soo right!! This dumb rsat program they keep sending these people doing is not doing any good. [...]
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Why Should We Care about High & Growing Inequality? How Unequal Are OECD Societies? Has Gap between Rich & Poor Widened? Possible Culprits in Growing Divide - What OECD Evidence Tells Us about Main Culprits - Importance of Tax/Benefit Systems - What Was the Impact of the Recent Great Recession? What Can Policies Do to Reduce Too-high Inequality?
Street protests are back on the global political scene. Do these movements reflect a frustrated middle class who feel the chill of the global economic crisis? Or are there more profound shifts at play?
Labour market reform to improve growth prospects and reduce inequality is a top priority in the face of rapid population ageing and a dualistic labour market. Sustaining output growth requires policies to mitigate the impact of rapid population ageing by increasing labour inputs from under-employed segments of the population.
Belgium has a good record in delivering accessible care, but adaptation to population ageing will be complicated by the fragmentation of responsibilities in the healthcare system and a strong reliance on government regulations.
Restoring fiscal sustainability is a major challenge in Slovenia. Yet, the performance in terms of expenditure control is poor and public expenditure on social spending increased briskly during the crisis, significantly more than on average across the OECD.
This paper proposes a new set of public health and long-term care expenditure projections until 2060, seven years after a first set of projections was published by the OECD. It disentangles health from long-term care expenditure, as well as the demographic from the non-demographic drivers, and refines the previous methodology, in particular by extending the country coverage.
This working paper reports on the work undertaken as part of the Tackling Long-term Unemployment Amongst Vulnerable Groups project. It includes the findings of a survey undertaken jointly by the OECD LEED Programme and the World Association of Public Employment Services in 2012, and also case studies and learning models from around the world on innovative practices to support the long-term unemployed into work.
This report provides an overview of the substantial ageing and employment policy initiatives already implemented in Norway over the past decade and identifies areas where more should be done, covering both supply-side and demand-side aspects.
To give better incentives to carry on working, the report recommends further reforms in the second-pillar pension schemes, particularly for public sector employees. On the side of
The number of people over 80 will double by 2050 rising from 3.9% of the population to 9.1% in 2050 across OECD countries and from 4.7% to 11.3% across 27 EU members. Estimates are that up to half of them will need help to cope with their daily needs. Yet even today governments are struggling to deliver high-quality care to elderly people with reduced physical and mental abilities, says a new OECD/EC report, A good life in old age? .
This publication presents an internationally agreed framework to support the joint analysis of micro-level statistics on household income, consumption and wealth. Its aim is to extend the existing international frameworks for measuring household income and consumption at the micro level to include wealth, and describes income, consumption and wealth as three separate but interrelated dimensions of people's economic well-being. The


text:
YogaGalNJ's review of Avon Avon Dew Kiss Lip Dew
126 reviews
84% would repurchase
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on 11/30/2003 6:23:00 AM
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AWESOME! I have loved this wonderful affordable lip balm for quite some time! It TRULY makes your lips moisturized & soft! I put this on every nite before going to bed. :o)
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text:
Ingram Micro house brand V7 has announced a new line of flat-panel TV wall mounts and plasma and LCD monitor stands for most brands of flat-panel TVs and LCD monitors, including V7's LCD TVs and LCD monitors.
The new mounts and stands are made from high-quality material and come with a locking quick-release bracket for easy installation and exchange. All are UL approved, conform to VESA standards and include all installation hardware.
Made of solid steel, V7's Universal Combo Display Wall Mounts are available in two sizes, one accommodating 23in to 37in displays, and the other 37in to 60in displays. The mounts can be installed flat against a wall for direct viewing of the flat-panel TV, or tilted down five degrees for an alternate viewing angle.
The Single Gas Arm Monitor Stand can support displays up to 28lbs. They are constructed of solid steel and will fit most brands of LCD monitors, 13in to 23in.
For more information, visit www.V7-world.com and www.ingrammicro.com.
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Huge Ultra HD Display Lights Up Times Square


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Tommy Hughitt
|Personal information
|Date of birth
|December 27, 1892
|Place of birth
|Genoa, British Columbia, Canada
|Date of death
|December 27, 1961(aged 69)
|Place of death
|Bartow, Florida, United States
|Career information
|Wide Receiver, Halfback, Quarterback, Punter, Place Kicker
|Career highlights
|1x George Halas: 1st team all-NFL (1922)
|Head coaching record
|Career record
|Playing stats
|Coaching stats
|Team(s) as a player
|Team(s) as a coach/administrator
Ernest Fredrick "Tommy" Hughitt[1] (December 27, 1892 – December 27, 1961) was a National Football League utility player and coach. He was also an All-American quarterback for the University of Michigan in 1913.
Hughitt was born in Genoa, British Columbia, but grew up in Escanaba, Michigan, where he attended high school. Upon graduation he went to the University of Michigan, where he played halfback and then quarterback for the Wolverines.[1]
From 1915 to 1916, Hughitt was the head football coach at the University of Maine.[1] He compiled a 6–7–3 overall record, including the Maine Intercollegiate Athletic Association championship in 1915. An article in The Michigan Technic commented on Hughitt's success at Maine:
"Due to the excellent coaching of 'Tommy' Hughitt, former varsity quarterback, the University of Maine football tam won the state championship this season. Hughitt showed the effectiveness of the Yost system of coaching by developing a bunch of green material, a tam which staged a real 'comeback' after a bad start last year. Maine is highly pleased with the work of Hughitt and has engaged him for this season."[2]
Hughitt went professional no later than 1917, when he signed with the Youngstown Patricians of the Ohio League. When the Patricians ceased operations due to the war and flu problems of 1918, Hughitt moved on to Buffalo Niagaras and Prospects of the Buffalo Semi-Pro Football League, returning to Youngstown in a brief and abortive attempt to relaunch the Patricians in 1919.
When the Prospects joined the ranks of the APFA (later known as the National Football League) in 1920, Hughitt was retained as the centerpiece of the now-renamed Buffalo All-Americans. During his APFA/NFL career, Hughitt was a triple threat man and player-coach at the same time, playing quarterback, wide receiver, running back, punter, placekicker, and playing on defense all the while coaching the team. He finished his career with an impressive 29–15–7 record, two state championships (1918 and 1919), two top-three finishes in the NFL (1920 and 1921), and statistically finishing at or near the top of the league in several scoring and receiving categories in 1920 and 1921 (the one-two punch of Hughitt and Ockie Anderson was one of the most potent in the nascent league); he never had a losing season in his entire time as coach. He retired from football in 1924, shortly after acquiring a stake in his team. After Hughitt's departure, he handed over the reins of the franchise to Walter Koppisch, and Hughitt spent time as a league official.
In 1937, he became a councilman for the City of Buffalo serving for a term of four years. He died in Bartow, Florida and was buried in Buffalo.[1] He was elected to Michigan's Upper Peninsula Sports Hall of Fame in 1992. However despite his record, Hughitt has never been considered for the Pro Football Hall of Fame.
Hughitt wore the number 1.
Head coaching record[edit]
|Maine Black Bears (Maine Intercollegiate Athletic Association) (1915–1916)
|National championship Conference title Conference division title
See also[edit]
- ^ a b c d "Tommy Hughitt Dies in Florida". The Escanaba Daily Press. December 29, 1961. p. 3. Retrieved May 7, 2015 – via Newspapers.com.
- ^ "Alumni Notes". The Michigan technic, Volumes 28-29. p. 231.
External links[edit]
- 1892 births
- 1961 deaths
- Canadian players of American football
- Canadian emigrants to the United States
- American football placekickers
- American football punters
- American football quarterbacks
- American football running backs
- Sportspeople from British Columbia
- Buffalo All-Americans players
- Buffalo Bisons (NFL) coaches
- Buffalo Bisons (NFL) players
- Maine Black Bears football coaches
- New York Pro Football League players
- Michigan Wolverines football players
- Youngstown Patricians players
- People from Escanaba, Michigan
- Players of American football from Michigan


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Dana Cranston is in the running for the prestigious NCAA Woman of the Year award.
July 26, 2013
INDIANAPOLIS, Ind. – Former Colorado State volleyball star Dana Cranston is in the running for another prestigious award. The NCAA announced Thursday its conference honorees for the 2013 NCAA Woman of the Year award.
Cranston, along with Wyoming's Chaundra Sewell, were named the two representatives from the Mountain West. In all, 146 female student-athletes – between Divisions I and III – were honored by their respective conference.
Originally nominated by her institution, each conference then selects one or two honorees to be reviewed by the NCAA. The Woman of the Year selection committee will then choose 30 honorees (10 from each division) to be recognized at a banquet in Indianapolis on Oct. 20, where this year's Woman of the Year will be named.
Since 1991, the Woman of the Year award honors graduating female student-athletes who have distinguished themselves throughout their collegiate careers in the areas of academic achievement, athletics excellence, service and leadership.
A total of 455 individuals were originally nominated by their institutions — including 214 Division I athletes. Of the 146 remaining, 58 competed at the Division I level, and 11 participated in Division I volleyball. For a complete list, click here.
Cranston, a four-time Mountain West champion who helped CSU to four NCAA tournament appearances, was named the 2012 Mountain West Player of the Year and an AVCA All-American. Away from the court, she became CSU volleyball's second-ever Capital One Academic All-American and was one of 10 finalists for the prestigious Senior CLASS Award, which, similar to the Woman of the Year, recognizes senior student-athletes who excel on the court, in the classroom, in the community and have great character.
In 2002, two-time AVCA first-team All-American and two-time Academic All-American Angela Knopf was recognized at the Woman of the Year banquet, after being named among the final 10 Division I honorees.
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Affordable Housing Rises Out Of Foreclosure Crisis
Lancaster, Calif., is a high desert community on the far outskirts of Los Angeles. Officials there are spending millions of dollars to fix up foreclosed properties and make them into affordable housing. The Department of Housing and Urban Development has announced $4 billion worth of grants to local development agencies nationwide to do the same thing.
Rob Schmitz of member station KQED talks with Renee Montagne about Lancaster's progress fighting the foreclosure crisis.
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"We believe such a decision, without justifiable reason, infringes our statutory right to submit shareholder proposals."
Related quotes
"Generally we don't like them as a basic principle. In some cases it is working reasonably well from a shareholder point of view and that has to do with the people involved."
"We're taking on Wall Street. We're buying 50 percent over the minimum number of shares required to submit a shareholder resolution."
"We would of course speak with any interested shareholder of relevant thoughts and perspectives. We have informed Icahn that we'd be happy to meet."
"That was the first flexing of shareholder muscle and that shareholders were emphasizing the importance of splitting those roles."
"The symptom was executive pay being non-aligned with shareholder interests and our response was to create an accountability mechanism for directors."
"We've had three years of shareholder gains and yet this is still a headline. Shareholders are still focusing on the issue."


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Proving once again that he's the master of merging musical universes, Bad Boy
Records impresario and rapper Sean "Puff Daddy" Combs takes to the stage
this weekend with legendary Led Zeppelin guitarist Jimmy Page for a special
performance on "Saturday Night Live."
The unlikely duo will be joined by a member of Fuzzbubble, the first rock band
signed to Puff Daddy's label, to perform the song "Come With Me," a track from
the upcoming soundtrack to the anticipated summer-blockbuster movie
Mimicking the sound of the recorded version, the performance will feature a 40-
piece orchestra, according to Fuzzbubble bass player Brett Rothfeld. "It
sounded amazing," said Rothfeld, who called just hours after the first run-
through of the song at the "SNL" studio on Thursday afternoon (May 7). Page,
who will join the band for a Saturday dry-run, did not attend the Thursday run-
through. Describing himself as a "huge Zeppelin fan growing up," Rothfeld said
he was excited to actually play with his hero Page on Saturday. The bassist
said the last time that he met the guitar god — during the mixing of the song — all
he really managed to do was slip in a handshake and photo op with Page.
Fuzzbubble do not appear on the album version of "Come With Me."
The song, based on the classic Zeppelin tune "Kashmir," had an unusual
genesis, according to Rage Against the Machine guitarist Tom Morello, who
also plays on the track. "We had, like, a day and a half in a studio in L.A. to do
it," Morello said of the sessions, which did not include Page.
Morello explained that he was surprised at how musically adept Puff Daddy was
in the studio, where the reigning king of hip-hop oversaw all aspects of the
recording session. Puff Daddy even brought in a large string section from the
L.A. Philharmonic for the session. "We all played the same part on the recorded
version," Morello said of the classic Zeppelin "Kashmir" riff that pervades the
tune. "And the song basically has five parts, so Puffy and I arranged it and
Jimmy [Page] had to learn our arrangement and then he recorded his part in
Although he was overjoyed to work with his hero Page, Morello said he had a
hard time learning the lifted riff from the song. "I love the album version, but I'm
going to also do a rock remix of it that will be real guitar-heavy," he said. "Both
Jimmy and I played a lot more 'guitar hero' parts than are on the album version,
which is maybe more hip-hop and hit-song oriented than crushing rock."
Morello said he doesn't know where or how his remix will be released just yet.
The guitarist, best known for his band's bombastic, hard-rock political anthems,
also said that despite the unlikelihood of the triple-threat combo on the song, he
had no qualms about working with Puff Daddy. "Whenever you go into a club
and his stuff comes on," Morello said, "it just goes off."
This isn't the first time that Puff Daddy has hit the stage with a rocker. He
performed his tribute to slain rapper Notorious B.I.G., "I'll Be Missing You" —
which samples the Police hit "Every Breath You Take" — with former Police
singer Sting at MTV's Video Music Awards and he brought in Foo Fighter Dave
Grohl and former Replacements bassist Tommy Stinson to do a rock remix of
the song "It's All About the
The all-star soundtrack to "Godzilla," Godzilla: The Album, features a
cover of the David Bowie song "Heroes" by the Wallflowers (the first single), as
well as new tracks by: Jamiroquai ("Deeper Underground"), Rage Against the
Machine ("No Shelter"), Ben Folds Five ("Air"), Foo Fighters ("A 320″), a remix of
Green Day's "Brainstew" and the recorded debut of Fuzzbubble with "Out
There." The soundtrack also features songs by Days of the New, Silverchair and
Michael Penn.


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Cognitive impairment, including dementia, is commonly seen in those afflicted with Parkinson disease (PD), particularly at advanced disease stages. Pathologically, PD with dementia (PD-D) is most often associated with the presence of cortical Lewy bodies, as is the closely related dementia with Lewy bodies (DLB). Both PD-D and DLB are also frequently complicated by the presence of neurofibrillary tangles and amyloid plaques, features most often attributed to Alzheimer disease. Biomarkers are urgently needed to differentiate among these disease processes and predict dementia in PD as well as monitor responses of patients to new therapies. A few clinical assessments, along with structural and functional neuroimaging, have been utilized in the last few years with some success in this area. Additionally, a number of other strategies have been employed to identify biochemical/molecular biomarkers associated with cognitive impairment and dementia in PD, e.g., targeted analysis of candidate proteins known to be important to PD pathogenesis and progression in cerebrospinal fluid or blood. Finally, interesting results are emerging from preliminary studies with unbiased and high throughput genomic, proteomic and metabolomic techniques. The current findings and perspectives of applying these strategies and techniques are reviewed in this article, together with potential areas of advancement.
Parkinson disease (PD), the second most common neurodegenerative disease after Alzheimer disease (AD), has been recently recognized as a disease that encompasses more than just nigrostriatal degeneration with motor dysfunction (43, 74). More specifically, a significant portion of PD patients suffer from non-motor symptoms, including anosmia, constipation, depression, autonomic failure, and cognitive dysfunction. There is growing evidence that cognitive symptoms are frequently present at the time of diagnosis (40), contribute heavily to disability (144), and progress to dementia at a rapid rate. PD with dementia (PD-D) shares a common neuropathological pattern, cognitive profile, and clinical course with a closely related condition, dementia with Lewy-bodies (DLB). The pathological hallmark of both PD-D and DLB is the presence of Lewy bodies — ubiquitin-positive and α-synuclein (α-Syn)-enriched intracytoplasmic neuronal inclusions — in neocortical and paralimbic regions, which seems to be one of the main pathological correlates of dementia in PD (3, 9). The cognitive profile of PD-D (and DLB for that matter) also overlaps partially with that of AD, the most common form of geriatric dementia, and AD-type pathology (such as neurofibrillary tangles and amyloid plaques) frequently co-exists with Lewy body pathology, making correct diagnosis of PD-D difficult even in the best hands. The sensitivity and specificity of the recently published PD-D diagnostic criteria (35, 38) have not yet been explored, but, as expected, the diagnosis will be challenging when patients fall in between the two classic profiles of DLB and PD-D (77). Even for clinical DLB, most studies based on the consensus criteria for clinical diagnosis of DLB (89, 90) have reported a high specificity (80–100%) but a low sensitivity (20–60%) (87), meaning that the consensus criteria are appropriate for confirmation of diagnosis but are of limited value in screening for DLB. In addition, distinguishing the Lewy body disorders from non-Lewy body dementias, including AD, remains difficult when atypical presentations occur during or at early stages of the diseases (78, 79, 88).
As such, identifying individuals who are predisposed to developing cognitive impairment and dementia in PD and other neurodegenerative disorders at early stages of disease progression will allow physicians to better assess the individual's prognosis and make informed decisions on the best course of management (141). In addition, potential neuroprotective or neurorestorative therapies and secondary prevention efforts might be expected to have their greatest impact during the earliest phases of the disease process. Therefore, during the development and implementation of neuroprotective therapies, it will be important to develop robust biomarkers - whether based on clinical assessment, structural/functional imaging, or biochemical measurement in body fluids - that can aid in specific and accurate diagnosis, particularly at early disease stages, and can objectively monitor progression and response to treatment. Biochemical/molecular markers, particularly, could also potentially reveal mechanisms involved in disease pathogenesis and thereby provide new targets for therapy.
Significant effort has been spent in several areas to define biomarkers for cognitive impairment in PD, including physiological/sensory testing, structural/functional neuroimaging, and biochemical determination of various molecules. Table 1 lists advantages, disadvantages, and the current status of the major techniques employed for PD-D and DLB biomarker discovery. Of note, the applications of structural and functional neuroimaging and electrophysiological techniques on the diagnosis of PD-D and DLB have already been extensively discussed previously (1, 6, 43, 112, 129).
Differences exist in the electrophysiological profiles of different types of dementia, both in the amount of slowing as well as the distribution of electrophysiological changes. Several electrophysiological studies have shown more slowing of electroencephalographic (EEG) rhythm in DLB than in AD (2). A recent study has shown that patients with DLB and PD-D have more posterior slow-frequency variation than patients with AD and healthy controls (18). Similarly, another study, which assessed mismatch negativity (MMN) of the auditory event-related potential (ERP), concluded that reduced latency and areas were found in PD-D, compared with AD, PD without dementia (PD-ND) patients, and healthy controls; furthermore, more pronounced changes were found in PD-D than those observed in DLB (22). Studies also reported that PD-D patients had distinctly slower baseline EEG activity than PD-ND patients (43), and that a positive correlation occurred between EEG frequency and cognitive scores (126). Although these results indicate that EEG and ERP may provide a potential diagnostic marker to distinguish between Lewy body disease (including PD-D and DLB) and other dementia diseases, most of these studies were based on small numbers of patients and provided no evidence indicating sensitivity and specificity values.
Additionally, olfactory dysfunction has been identified in PD-D and DLB (55, 117); but this observation is nonspecific because patients with AD have similar olfactory deficits. It could be that the main utility of olfactory testing may be to differentiate neurodegenerative diseases from non-neurodegenerative dementia, such as multi-infarct state, that have no impairment of olfaction (45).
Neuroimaging studies using structural magnetic resonance imaging (MRI) have demonstrated that PD-D is associated with cortical atrophy and that the pattern of atrophy differs from that of AD (24), with significant differences between PD-D and PD-ND reported bilaterally in the occipital lobes. Greater whole-brain atrophy rates were observed in PD-D patients than in PD-ND patients and healthy control subjects (23). Regional changes in key areas such as caudate (7), hippocampus (25), and amygdalae (69) were also reported to be associated with PD-D. Notably, atrophy of the amygdalae and the head of hippocampus were reported recently in PD patients without dementia, indicating early memory impairment (20, 68). Similarly, two recent studies (12, 92) have reported areas of brain atrophy in PD with mild cognitive impairment (MCI) for early changes. Still, there is considerable overlap of regional patterns of atrophy that occur between PD-D and PD-ND and between PD-D and DLB (25, 69). Moreover, sample sizes have not been large enough in most studies to allow for statistical modeling to control for the increased motor impairment and longer disease duration often seen in PD-D compared with PD-ND patients (38, 43).
Functional neuroimaging modalities, including positron emission tomography (PET), single photon emission computer tomography (SPECT), and functional MRI (fMRI), provide valuable information on brain function in the neuropsychiatric aspects of PD. A characteristic posterior perfusion deficit or decreased cerebral blood flow has been shown by SPECT in PD-D as well as DLB (8), but whether this observation is sufficiently distinctive for PD-D and clinically useful for diagnostic purposes remains to be investigated (38, 43). fMRI has also been used to identify brain changes associated with visual hallucinations in PD (132), and the use of 18F-fluorodeoxyglucose (FDG) PET to study non-demented PD patients while they were performing executive and memory tasks, has identified a metabolic pattern (60). It has appeared that changes in this network could distinguish PD with and without MCI (59), and more importantly, changes in this network with time (i.e. progression) were identified (61).
Both PET studies using 18F-fluorodopa and SPECT studies using a range of ligands that bind to the dopamine transporter (DAT) have been shown to identify dopaminergic deficits in PD (45). A growing body of literature shows that these same dopaminergic deficits can be found in PD-D or DLB and that these imaging modalities may be used to differentiate Lewy body disorders from AD. 18F-dopa uptake in PD-D has been reported to be significantly decreased in several areas compared with PD (64); however, in other studies, no differences in dopaminergic loss and rate of dopamine decline were found in PD-D and PD-ND patients (32, 115). Also, functional imaging of the cholinergic system has shown substantial cholinergic denervation in PD-D patients as compared with PD-ND patients (17, 57), although differences were not always significant (17).
In PET studies, 11C-Pittsburgh Compound B (PIB) binds to amyloid with a pattern similar to the histopathologically known distribution in AD. Elevated PIB-binding in the brain stem of PD was recently reported, and in a subgroup, cortical PIB binding was indeed found (81, 82), indicating that PIB-PET could be used to further differentiate PD-D with respect to cortical amyloid.
Finally, though currently preliminary, a few novel functional neuroimaging based biomarkers for PD-D have been investigated. For instance, lactate/N-acetyl aspartate ratio was found to be increased in the occipital lobes in PD, particularly in PD-D patients as compared to healthy controls, suggesting that the impairment of oxidative energy metabolism is greater in PD-D (21, 38). Additionally, using proton magnetic resonance spectroscopy, N-acetyl aspartate was found to be decreased in the occipital lobes in PD-D patients as compared to healthy control or PD-ND subjects (134). Also, the uptake of cardiac metaiodobenzylguanidine (MIBG), a specific marker for noradrenergic transporters, is significantly reduced in PD (135, 147) as well as in DLB (105). Although specific studies in PD-D are lacking, MIBG has been found to be more accurate than occipital hypoperfusion using SPECT (51) or CSF markers (140) as a means of discriminating between DLB and AD. Cardiac MIBG may differentiate Lewy body-related dementias from non-Lewy body related types, but cannot differentiate PD-D and DLB.
Taken together, group differences between PD-D/DLB and PD-ND patients have been documented in electrophysiological/sensory studies as well as structural and functional imaging investigations; however, none of these techniques can be recommended for current routine diagnostic purposes because of inadequate sensitivity or specificity, or relatively high expenses (43). Consequently, additional biomarkers with higher sensitivity and specificity, which can also be applied widely and at a reasonable cost, are needed for greater accuracy and diagnostic utility, ideally at preclinical or early stages of disease when therapy is likely to have the greatest impact.
Familial aggregation of PD-D and an increased frequency of dementia in the relatives of PD or PD-D patients have been reported in some studies (73, 85), probably reflecting an influence of genetic factors in the development of dementia in PD. The precise role of genetic factors in development of MCI and dementia in PD is unclear currently, though a few candidate genes have been implicated.
Based on these findings, it is clear that genetic testing, at least in its current form, is not a convenient or reliable source of biomarkers for diagnosis of cognitive impairment in PD.
Human CSF, being most proximal to the CNS, is one of the ideal sources for identifying biomarkers for neurodegenerative diseases. An important consideration is relative availability of CSF obtained by lumbar puncture, making it possible to conduct longitudinal molecular analyses of changes in CSF during the course of diseases. In addition to CSF, the use of plasma, urine, and saliva for biomarker discovery have also been explored as more practical/acceptable approaches; nevertheless, with only few exceptions these attempts have met with limited success, primarily because of the complexity of peripheral samples and confounding factors introduced by other organ systems (123). It was proposed that the best approach might be to establish an ensemble of effective biomarkers in well-characterized human CSF of a relatively small number of individuals involved in research settings, then subsequently pursue their quantification in plasma or urine/saliva for more wide spread application (148). The biochemical/molecular candidate markers will be reviewed in two categories – targeted analysis and unbiased profiling.
Other candidate molecular/biochemical markers include hypocretin, a protein related to the regulation of sleep and wakefulness (94, 146), tissue transglutaminase (138) and serpins (102) that might be associated with aggregation of α-syn, homocysteine (63), neurotransmitter metabolites such as homovanillic acid (HVA) and methoxy-hydroxy-phenyl-ethylene glycol (MHPG) (5, 27, 108), growth hormone in serum (31, 70, 110, 111, 118), osteopontin (80), amino acids relevant for synthesis of nitrogen monoxide (72, 84, 95), and metals such as iron and zinc (41, 42, 66, 114). Unfortunately, studies involving these candidate markers are either contradictory or very preliminary, and thus still difficult to interpret.
In summation, though the emerging body of work on the CSF and blood biomarkers of PD is encouraging (a list of recent findings, along with the associated references, is summarized in Table 2), one of the issues that has plagued the field is a lack of reproducibility between researchers. The disparity can be attributed to several factors, including variation in antibodies that might detect different species of the target protein, limited numbers of patients in some investigations, a less than vigorous quantitative method, or inadequate control for important confounding factors, particularly blood contamination in CSF (148). Further studies are needed to clarify these issues, ideally in CSF and blood samples with pathological verification of clinical diagnosis of each case.
While targeted analysis of biomarkers as discussed above is largely an extension of physiological studies that investigate known pathways involved in PD pathogenesis, emerging technologies are beginning to allow a systematic, unbiased characterization of variation in genes, messenger RNA (mRNA), proteins and metabolites associated with disease conditions and identification of novel biomarkers (49, 120, 123).
Over the last few years, proteomic techniques have been utilized to discover novel markers in different neurodegenerative disease settings, with AD being studied most extensively (33, 121, 123, 130). On the other hand, it has also become clear that the proteomics results reported by different groups vary substantially. Some of these variations may be biological, as human beings are extremely heterogeneous, and most diseases studied are very complex. To resolve this issue, multiple markers may be needed, as a combination of independent markers likely enhances the performance of the putative markers required (4, 29, 125). In addition, standardization of data reported is also critical to reducing inconsistency among different studies. It is almost certain that the differences in databases has contributed to the current inconsistent (and often contradicting) results in CSF biomarker discovery (148). As one of the initiatives to address this issue, we have recently summarized and standardized all of our CSF proteomics results, as well as made the original MS data available to investigators in the field (107) so that future discoveries can be compared to the published results meaningfully.
In proteomic studies for PD biomarker discovery in CSF, one recent study employed an unbiased quantitative proteomic approach called isobaric tagging for relative and absolute protein quantification (iTRAQ) to label human CSF from AD, PD, and DLB patients and healthy controls, and identified more than 1500 proteins; of those, 136, 72, and 101 proteins appeared to be uniquely associated with AD, PD, and DLB, respectively (4). Some of the unique proteins, including apolipoprotein H/beta-2-glycoprotein 1 (Apo-H), ceruloplasmin and chromogranin B (secretogranin I) that are unique to PD as well as apoC1 and T-cadherin that are unique to DLB, were further confirmed in the initial study using Western blotting. Additionally, the ability to distinguish DLB from PD and AD increased when several markers were combined. Besides the proteins confirmed in this initial investigation, several other markers have been tested in a different and larger set of subjects, in which a panel of eight CSF proteins (BDNF, IL-8, VDBP, β2-microglobulin, apoAII, apoE, plus tau and Aβ1-42) appears to be able to classify PD patients with 95% sensitivity and 95% specificity using bead-based Luminex multi-analyte profiling technology (149). Whether these markers are useful in detecting PD-D/DLB remain to be investigated.
It cannot be stressed enough that biomarker discovery does not have to start with body fluids. This is because protein biomarkers identified in human brain may also ultimately enter CSF and/or plasma that can be collected clinically in a living patient. These brain specific markers are difficult to identify in unbiased direct profiling of CSF because they are typically low in abundance, and all current proteomics technology is biased towards abundant proteins. Thus, defining proteins in well-characterized brain tissue, followed by targeted validation of candidate proteins in the CSF and blood is indeed an approach currently taken for PD and DLB biomarker discovery. In this regard, several tissue-based proteomics studies have identified many differentially expressed proteins in PD tissues with respect to controls (11, 67, 71, 106, 122, 124, 145). Some of the proteins, including mortalin (124) and glutathione S-transferase pi (122), were also identified to display significant differences between different PD stages. A subset of these proteins is under intensive investigation as to their contribution to PD development and progression. The deregulated proteins in PD tissue are also being interrogated as potential biomarkers in body fluids, including CSF and plasma.
The advantages of early diagnosis, combined with suboptimal clinical diagnostic accuracy, highlight the need for a valid biological marker(s) for PD with MCI and PD-D. Promising results have been reported from several neuroimaging and hypothesis-driven targeted analysis of proteins in CSF and blood. Unbiased discovery based on genomics, metabolomics, and proteomics has also yielded hopeful results. It is expected that future studies using these strategies will provide novel, more accurate, and less expensive biomarkers and explore whether a combination of different biomarkers can improve diagnostic accuracy. Another potential fruitful area in discovery of biomarkers for cognitive impairment might be the research on post-translational modifications (PTMs) of proteins, e.g. phosphorylation, ubiquitination, and glycosylation, as aberrant PTMs of proteins have now been recognized as an attribute of many mammalian diseases, including neurodegenerative diseases (10, 44, 91). To this end, phosphorylated and/or glycosylated α-syn have been clearly linked to PD pathogenesis, and it is possible that it is the modified α-syn, rather than the total level of α-syn, that reflects disease activity and prognosis. More detailed discussions of the current technologies being utilized as well as potential shortcomings and limitations of the analysis of PTMs as biomarkers of neurodegenerative disease can be found in recently published reviews (26, 148).
Finally, for future investigations, it is critical to address several important issues, including standardization of sample collection protocols, the specificity of the antibodies and the technologies used, and the need to recruit a larger number of subjects and controls, allowing for stratification against important variables typically associated with clinical investigations. These variables have likely contributed to inconsistent results, whether via targeted or unbiased profiling, obtained thus far by various investigators. Independent studies on different cohorts, including cases with pathological verification, are also needed for validation.
This work was supported by grants from the NIH (NS057567, NS060252, ES004696, AG033398, AG025327, and NS062684) and the C-M Shaw Endowment.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Yossi Benayoun really wants to come to MLS
May 31, 2013, 5:50 PM EDT
Headed out the door at Stamford Bridge, Chelsea's Yossi Benayoun has made it clear he wishes to play in the United States as soon as possible.
"I finish my contract on 30th June" Benayoun told Sky Sports. "At the moment I'm in talks with several European teams. I'm checking my options but, to tell you the truth, America is one of my favourite options. I'm trying to do everything I can to come to America and play in the MLS, and hopefully it works out in the next few weeks."
The Israeli international said he was very close to signing a deal with the New York Red Bulls last summer, but now he's "checking his options" says agent Ronen Katzav.
Katzav says the idea to come to Major League Soccer stems from Benayoun's desire for a new challenge. "We also have options in Europe – Spain, Germany and, of course, England a few clubs, top leagues" Katzav said. "But we're trying to change a little bit the mentality of life a little bit from Europe. You know when you are a football player, one of the things is to test. To test things and maybe to change some things to another country, another mentality, another way of life and another football."
New York have been on the lookout for a fit to be their third Designated Player – a slot which lies empty at the moment. Sporting Director Andy Roxburgh quieted talks of a move for Kaka or Eric Abidal, but it appears Benayoun would be willing to make the switch.
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Winter Wonderland: 17 Winter Patterns to Crochet
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Hooded Sweater
By: Bernat
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Who doesn't love a hooded sweater? The chunky yarn used in this free crochet pattern makes it quick and easy to make.
Crochet Hook: J/10 or 6 mm hook
Yarn Weight: (5) Bulky/Chunky (12-15 stitches for 4 inches)
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Franchise Opportunities
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A franchise provides franchisees with a certain level of independence where they can operate their business.
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The International Franchise Association is committed to educating prospective franchisees on the dynamics of franchising and providing them with information to begin their evaluation of whether to become a franchisee. Beginning with the adoption in 1970 of the first franchise disclosure requirement in California.
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