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Why CHOC?Because our mission is your mission: to nurture, advance and protect the health and well being of children.
OhioHealth Riverside Methodist Hospital is looking for experienced, full-time Staff RNs to work in our Emergency Department.
Join one of the Top 100 health care systems in the nation. With 38 locations throughout Central Texas, Seton Healthcare Family is a growing center for medical research and education and is home to the region's only 4 Magnet® recognized hospitals.
We are currently looking for an Emergency Nurse for both Part-Time and Per Diem positions.
Director of Nursing - Multi Specialty and Multi Site Medical Clinic - based in Gastonia with travel to surrounding cities where offices are located - MUST have years of supervisory and operating room experience
Poplar Springs Hospital
We have an exciting opportunity for an experienced Nurse Manager to join our dynamic, quality-focused Emergency Services team at Legacy Good Samaritan Medical Center.
Arrowhead LLC
Forest View Hospital
Northern Nevada Medical Center
Wellington Regional Medical Center


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This review is from: EVGA 01G-P4-3655-KR GeForce GTX 650 Ti BOOST 1GB 192-Bit GDDR5 PCI Express 3.0 x16 SLI Support Video Card
Pros: great, stable card
Cons: wish I had bought the 2GB version
Other Thoughts: I'm running larger dual monitors now and wish I had gotten the 2GB modelREAD FULL REVIEW
This review is from: Microsoft SIDEWINDER X4 Keyboard - Retail
Pros: backlight, works great
Cons: none
Other Thoughts: Fantastic keyboard, I have been using it for over almost 2 years and it has worked very well, I am considering getting another one for my brotherREAD FULL REVIEW
This review is from: ASUS M4N98TD EVO AM3 NVIDIA nForce 980a SLI ATX AMD Motherboard
Pros: great board with one exception
Cons: wish it had a 6th sata port
Other Thoughts: board does everything except run my front eSATA port on my case, I came up one short on number of ports, but that would be my fault for not paying attention to the details pageREAD FULL REVIEW
Display Name: Joseph L.
Date Joined: 07/08/11
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Technology Briefing | Internet: Broadband Growth Prediction
Published: July 9, 2004
Broadband Internet access is expected to have 325 million subscribers worldwide by 2008, up from about 100 million at the end of 2003, according to research from the Yankee Group. Of the 325 million, about 200 million will use digital subscriber line service, up from the 85 million expected to be using it by the end of 2004, the study said. D.S.L. growth will be fed mostly by the Asia-Pacific region, according to the Yankee Group. D.S.L. is expected to add 25 million to 30 million subscribers a year, while cable modem service will add around 8 million a year. The Yankee Group expects steeper year-over-year growth for satellite, broadband wireless and other technologies as well. In North America, though, cable service will maintain its lead, rising to about 75 million subscribers in 2008 from 34 million at the end of 2003.


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33 year old woman | Cincinnati, OH, USA | Seeking men 31-38 within 30 miles
Don't take life too seriously, have fun and laugh often!
I have lived a few other places, but Cincinnati is my home. This city, in my opinion, has it all! I value my family and my friends and am the happiest when I am spending time with them. I have a nephew and two nieces (about to be three) and they mean the world to me – kids are such a blessing. I volunteer at Cincinnati Children's and it is the highlight of my week. We are lucky to be healthy and these children are incredibly brave and so strong. It is inspiring. I work for a local non-profit and this work is rewarding because I believe in our mission. I do believe that we are leaving a lasting impact on the community. This work also allows me to embrace one of my passions – traveling. I love experiencing new cultures and exploring the beauty and history around the world. A few simple pleasures I love the most: sports (playing and watching), cooking (and eating sushi), camping (campfires are the best), boating (there is something heavenly about being on the water), being outdoors (hiking or just relaxing in a park) and coffee (especially on my balcony). A few things I would still like to do: take a cooking class, learn another language, go skydiving, write a book, and travel to Australia. What I'm looking for right now: I enjoy meeting new people and hearing their stories but ultimately I am ready to meet someone who is interested in making plans and tackling life together. I am excited about the next chapter and am hoping to be able to share those moments with someone special.
Camping , Coffee and conversation , Business networking , Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Playing cards , Playing sports , Religion/Spiritual , Travel/Sightseeing , Video games , Volunteering , Watching sports , Wine tasting
Baseball, Basketball, Billiards / Pool, Bowling, Cycling, Dancing, Football, Other types of exercise, Running, Skiing, Soccer, Swimming, Tennis / Racquet sports, VolleyBall, Walking / Hiking, Weights / Machines, Yoga
I exercise 3-4 times per week.
Middle of the Road
University of Cincinnati, Cincinnati, OH
I think favorites are really hard to pick because it really depends on the situation. Here are a few: Overall: Friends and family Food: Seafood Sushi Vacation: Italy Movie: Serendipity Holiday: Christmas
I enjoy cooking, boating, camping, checking out local restaurants, museums and new attractions, sports.
Lean In by Sheryl Sandberg
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'2" (157cms)
|5'8" (172cms) to 6'4" (193cms)
|Body type:
|Slender, Athletic and toned
|No preference
|Light brown
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker
|Sales / Marketing
|No preference
Marketing Director for a local non-profit.
|I'll tell you later
|No preference
|Never Married
|No preference
|Have kids:
|No preference
|Wants kids:
|Definitely, Someday
|White / Caucasian
|No preference
|Christian / Catholic
|No preference
|Graduate degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral


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This 1971 Ferrari 246 GT Dino is a very original California car that's been under the same ownership for the last 25 years. Blue... More
Yellow Brake Calipers; Central Tunnel in Leather; Scuderia Ferrari Schields; Front and Rear Parking Sensors; 20in Diamond Finish Sport Wheels;... More
This 1972 Ferrari 246GT Coupe. Red with Tan interior. Car was owned by the same Gentleman since 1979. Excellent paperwork. Very desirable Euro model... More
1971 Ferrari GTC/4 Coupe (U.S. Version) Chassis No. 14619 One of only 500 units produced from 1971-1972 Documented by Ferrari historian Marcel Massani Striking Original Color Combination of Verde... More
Ferrari 328 GTS LHD in superb throughout condition! Third owner car with only 45000 kms from new with full (service) history, books and tools!... More
Beautiful Ferrari 412i LHD with a five speed manual gearbox (One of only 270 made)! Original Swiss car, now with German papers and registration.... More
6 Speed Manual Transmission, Red With Crema Leather Interior. Only 11,644 Documented Miles. Electrically Operated Seats, Original Boot Cover, Original Manuals. It's As... More
Meticulously Serviced And Maintained With Service Records. Red With Black Leather Interior Driven Only 14,457 Documented Miles. Original Emergency Tire. Original Booth Cover.... More
Call 440-914-0000 or email [contact seller] 1992 Ferrari 512 TR The Tubi exhaust digs this car's already considerable claws even deeper into your psyche. Description... More
1978 Ferrari 308 GTS '78 Ferrari 308GTS with 84,938 on the odometer in silver with black interior. Excellent color combination. Comes with a 5 speed... More
This 1972 Ferrari 365GTC/4 is matching numbers example that's been sitting in a garage for the last 5 years and is ready for a... More
F40 Motorsports is proud to offer this stunning 1984 Ferrari 512bbi. S/N 49027 is in spectacular condition and has only 8,419 Original Miles. This... More
1986 Ferrari 328GTS '86 Ferrari 328GTS in Rosso corsa with tan interior. A timeless color combination on this car and very presentable. Comes with a... More
1987 Ferrari 328GTS '87 Ferrari 328GTS in nero with black interior. Comes equipped with a 5 speed manual transmission, alloy wheels, power windows and air... More
This listing is for a beautiful 1990 Ferrari Testarossa in like new condition. Garage kept and perfectly maintained, with restorations that make it like... More


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Aliases for COPZ1 Gene
Aliases for COPZ1 Gene
External Ids for COPZ1 Gene
- Entrez Gene: 22818
- Ensembl: ENSG00000111481
- UniProtKB: P61923
Previous Symbols for COPZ1 Gene
Summaries for COPZ1 Gene
This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for COPZ1 Gene
COPZ1 (Coatomer Protein Complex, Subunit Zeta 1) is a Protein Coding gene. Among its related pathways are COPI Mediated Transport and COPI Mediated Transport.
UniProtKB/Swiss-Prot for COPZ1 Gene
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex


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The year 2015 has begun with some high-profile legal cases pitting the Church against the State. The following six cases will impact Church/State relations, and should be of particular interest to concerned Catholics. 1. CONESTOGA WOOD SPECIALTIES On Friday, January 23, the Obama Administration was required to pay $570,000 to cover attorney fees for Conestoga Wood Specialties, costs incurred in its federal lawsuit challenging the Obama administration abortion-pill mandate. The mandate forces … [Read more...]
Church Vs. State: Six Court Cases To Watch
EWTN Gets Its Day in Court
February 4, 2015. Mark your calendar. That's the day when oral arguments will be heard in the Eternal Word Television Network's case against the HHS Mandate.The Becket Fund for Religious Liberty, which is defending EWTN in the 11th Circuit Court of Appeals, in its media advisory called EWTN "a Catholic network whose sole purpose is to spread the word of God," and noted that EWTN must fight for the right to remain faithful to the very religious message it advances.If they were to lose, E … [Read more...]
BREAKING: Ave Maria School of Law Wins Its HHS Mandate Case in Federal Court
The Obama Administration has suffered another defeat in its quest to force Catholics and people of faith to pay for abortion-causing drugs, as required by the HHS Mandate. Today the U.S. District Court for the Middle District of Florida came down in favor of Ave Maria School of Law, ruling that the Catholic law school cannot be forced to implement portions of the HHS Mandate which compel faith-based organizations to pay for abortion-causing drugs for their employees. Attorneys from Alliance De … [Read more...]


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Mahtab Moayeri
Cell Biology, Microbiology, Molecular Biology
Article: Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines[Show abstract] [Hide abstract]
ABSTRACT: Background Lethal and edema toxin contribute to shock and lethality with Bacillus anthracis. We showed previously in a 96-h sedated canine model that raxibacumab, a monoclonal antibody against protective antigen, augmented hemodynamic support (HS) and improved survival with lethal toxin challenge. Here we study raxibacumab further. Using this model, we have now studied raxibacumab with 24 h edema toxin challenges (Study 1), and lethal and edema toxin challenges together (Study 2). Methods Using our canine model, we have now studied raxibacumab with 24h edema toxin challenges (Study-1), and lethal and edema toxin challenges together (Study-2). Results In Study 1, compared to no treatment, HS (titrated fluid and norepinephrine) increased mean arterial blood pressure (MAP, p ≤ 0.05) but not survival [0 of 10 (0/10) animals survived in each group] or median survival time [43.8 h (range 16.8 to 80.3) vs. 45.2 h (21.0 to 57.1)]. Compared to HS, HS with raxibacumab treatment at or 6 h after the beginning of edema toxin increased MAP and survival rate (6/7 and 7/8, respectively) and time [96.0 h (39.5 to 96.0) and 96.0 h (89.5 to 96.0), respectively]; (p ≤ 0.05). HS with raxibacumab at 12 h increased MAP (p ≤ 0.05) but not survival [1/5; 55.3 h (12.6 to 96.0)]. In Study-2, survival rate and time increased with HS and raxibacumab at 0 h (4/4) or 6 h after (3/3) beginning lethal and edema toxin compared to HS [0/5; 71.5 h (65 to 93)] (p = 0.01 averaged over raxibacumab groups). Conclusions Raxibacumab augments HS and improves survival during shock with lethal and edema toxin.02/2015; 3(1). DOI:10.1186/s40635-015-0043-4
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ABSTRACT: Inflammasomes are cytosolic protein complexes that respond to diverse danger signals by activating caspase-1. The sensor components of the inflammasome, often proteins of the nucleotide-binding oligomerization domain-like receptor (NLR) family, detect stress, danger stimuli, and pathogen-associated molecular patterns. We report that the eicosanoid 15-deoxy-Δ(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 activation by the NLR family leucine-rich repeat protein (NLRP)1 and NLRP3 inflammasomes. This inhibition was independent of the well-characterized role of 15d-PGJ2 as a peroxisome proliferator receptor-γ agonist, its activation of NF erythroid 2-related factor 2, or its anti-inflammatory function as an inhibitor of NF-κB. Instead, 15d-PGJ2 prevents the autoproteolytic activation of caspase-1 and the maturation of IL-1β through induction of a cellular state inhibitory to caspase-1 proteolytic function. The eicosanoid does not directly modify or inactivate the caspase-1 enzyme. Rather, inhibition is dependent on de novo protein synthesis. In a mouse peritonitis model of gout, using monosodium urate crystals to activate NLRP3, 15d-PGJ2 caused a significant inhibition of cell recruitment and associated IL-1β release. Furthermore, in a murine anthrax infection model, 15d-PGJ2 reversed anthrax lethal toxin-mediated NLRP1-dependent resistance. The findings reported in this study suggest a novel mechanism for the anti-inflammatory properties of the cyclopentenone PGs through inhibition of caspase-1 and the inflammasome.
Article: A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model[Show abstract] [Hide abstract]
ABSTRACT: Anthrax disease is caused by a toxin consisting of protective antigen (PA), lethal factor (LF) and edema factor (EF). Antibodies (Abs) against PA have been shown to be protective against the disease. Variable domains of camelid heavy chain-only Abs (VHHs) with affinity for PA were obtained from immunized alpacas and screened for anthrax neutralizing activity in macrophage toxicity assays. Two classes of neutralizing VHHs were identified recognizing distinct, non-overlapping epitopes. One class recognizes domain 4 of PA at a well-characterized neutralizing site through which PA binds to its cellular receptor. A second neutralizing VHH (JKH-C7) recognizes a novel epitope. This antibody inhibits conversion of the PA oligomer from 'pre-pore' to its SDS and heat-resistant 'pore' conformation while not preventing cleavage of full length 83-kDa PA (PA83) by cell surface proteases to its oligomer-competent 63-kDa form (PA63). The antibody prevents endocytosis of the cell surface generated PA63 subunit but not pre-formed PA63 oligomers formed in solution. JKH-C7 and the receptor-blocking VHH class (JIK-B8) were expressed as a heterodimeric VHH-based neutralizing agent (VNA2-PA). This VNA displayed improved neutralizing potency in cell assays and protected mice from anthrax toxin challenge with much better efficacy than the separate component VHHs. The VNA protected virtually all mice when separately administered at a 1:1 ratio to toxin, and protected mice against Bacillus anthracis spore infection. Thus, our studies show the potential of VNAs as anthrax therapeutics. Due to their simple and stable nature, VNAs should be amenable to genetic delivery or administration via respiratory routes. Copyright © 2015, The American Society for Biochemistry and Molecular Biology.Journal of Biological Chemistry 01/2015; 290(10). DOI:10.1074/jbc.M114.627943 · 4.60 Impact Factor
Article: Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii[Show abstract] [Hide abstract]
ABSTRACT: Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent on the activation of the innate immune response. In this study, we investigated the role of cytoplasmic nucleotide-binding domain and leucine-rich repeat containing a pyrin domain (NLRP) inflammasome sensors during acute toxoplasmosis in mice. We show that in vitro Toxoplasma infection of murine bone marrow-derived macrophages activates the NLRP3 inflammasome, resulting in the rapid production and cleavage of interleukin-1β (IL-1β), with no measurable cleavage of IL-18 and no pyroptosis. Paradoxically, Toxoplasma-infected mice produced large quantities of IL-18 but had no measurable IL-1β in their serum. Infection of mice deficient in NLRP3, caspase-1/11, IL-1R, or the inflammasome adaptor protein ASC led to decreased levels of circulating IL-18, increased parasite replication, and death. Interestingly, mice deficient in NLRP1 also displayed increased parasite loads and acute mortality. Using mice deficient in IL-18 and IL-18R, we show that this cytokine plays an important role in limiting parasite replication to promote murine survival. Our findings reveal T. gondii as a novel activator of the NLRP1 and NLRP3 inflammasomes in vivo and establish a role for these sensors in host resistance to toxoplasmosis.mBio 12/2014; 5(1). DOI:10.1128/mBio.01117-13 · 6.88 Impact Factor
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ABSTRACT: The pathophysiological effects resulting from many bacterial diseases are caused by exotoxins released by the bacteria. Bacillus anthracis, a spore-forming bacterium, is such a pathogen, causing anthrax through a combination of bacterial infection and toxemia. B. anthracis causes natural infection in humans and animals and has been a top bioterrorism concern since the 2001 anthrax attacks in the USA. The exotoxins secreted by B. anthracis use capillary morphogenesis protein 2 (CMG2) as the major toxin receptor and play essential roles in pathogenesis during the entire course of the disease. This review focuses on the activities of anthrax toxins and their roles in initial and late stages of anthrax infection.Trends in Microbiology 03/2014; DOI:10.1016/j.tim.2014.02.012 · 9.81 Impact Factor
- Cell metabolism 03/2014; 19(3):345-346. DOI:10.1016/j.cmet.2014.02.002 · 16.75 Impact Factor
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ABSTRACT: Toxoplasma gondii is an intracellular parasite that infects a wide range of warm-blooded species. Rats vary in their susceptibility to this parasite. The Toxo1 locus conferring Toxoplasma resistance in rats was previously mapped to a region of chromosome 10 containing Nlrp1. This gene encodes an inflammasome sensor controlling macrophage sensitivity to anthrax lethal toxin (LT) induced rapid cell death (pyroptosis). We show here that rat strain differences in Toxoplasma infected macrophage sensitivity to pyroptosis, IL-1β/IL-18 processing, and inhibition of parasite proliferation are perfectly correlated with NLRP1 sequence, while inversely correlated with sensitivity to anthrax LT-induced cell death. Using recombinant inbred rats, SNP analyses and whole transcriptome gene expression studies, we narrowed the candidate genes for control of Toxoplasma-mediated rat macrophage pyroptosis to four genes, one of which was Nlrp1. Knockdown of Nlrp1 in pyroptosis-sensitive macrophages resulted in higher parasite replication and protection from cell death. Reciprocally, overexpression of the NLRP1 variant from Toxoplasma-sensitive macrophages in pyroptosis-resistant cells led to sensitization of these resistant macrophages. Our findings reveal Toxoplasma as a novel activator of the NLRP1 inflammasome in rat macrophages.PLoS Pathogens 03/2014; 10(3):e1003927. DOI:10.1371/journal.ppat.1003927 · 8.06 Impact Factor
Article: Arsenic Trioxide and Other Arsenical Compounds Inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 Inflammasomes[Show abstract] [Hide abstract]
ABSTRACT: Inflammasomes are large cytoplasmic multiprotein complexes that activate caspase-1 in response to diverse intracellular danger signals. Inflammasome components termed nucleotide-binding oligomerization domain-like receptor (NLR) proteins act as sensors for pathogen-associated molecular patterns, stress, or danger stimuli. We discovered that arsenicals, including arsenic trioxide and sodium arsenite, inhibited activation of the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes by their respective activating signals, anthrax lethal toxin, nigericin, and flagellin. These compounds prevented the autoproteolytic activation of caspase-1 and the processing and secretion of IL-1β from macrophages. Inhibition was independent of protein synthesis induction, proteasome-mediated protein breakdown, or kinase signaling pathways. Arsenic trioxide and sodium arsenite did not directly modify or inhibit the activity of preactivated recombinant caspase-1. Rather, they induced a cellular state inhibitory to both the autoproteolytic and substrate cleavage activities of caspase-1, which was reversed by the reactive oxygen species scavenger N-acetylcysteine but not by reducing agents or NO pathway inhibitors. Arsenicals provided protection against NLRP1-dependent anthrax lethal toxin-mediated cell death and prevented NLRP3-dependent neutrophil recruitment in a monosodium urate crystal inflammatory murine peritonitis model. These findings suggest a novel role in inhibition of the innate immune response for arsenical compounds that have been used as therapeutics for a few hundred years.The Journal of Immunology 12/2013; 192(2). DOI:10.4049/jimmunol.1301434 · 5.36 Impact Factor
Article: Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin.[Show abstract] [Hide abstract]
ABSTRACT: Anthrax lethal toxin is a classical AB toxin comprised of two components: protective antigen (PA) and lethal factor (LF). Here, we show that following assembly and endocytosis, PA forms a channel that translocates LF, not only into the cytosol, but also into the lumen of endosomal intraluminal vesicles (ILVs). These ILVs can fuse and release LF into the cytosol, where LF can proteolyze and disable host targets. We find that LF can persist in ILVs for days, fully sheltered from proteolytic degradation, both in vitro and in vivo. During this time, ILV-localized LF can be transmitted to daughter cells upon cell division. In addition, LF-containing ILVs can be delivered to the extracellular medium as exosomes. These can deliver LF to the cytosol of naive cells in a manner that is independent of the typical anthrax toxin receptor-mediated trafficking pathway, while being sheltered from neutralizing extracellular factors of the immune system.Cell Reports 11/2013; DOI:10.1016/j.celrep.2013.10.019 · 7.21 Impact Factor
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ABSTRACT: Anthrax edema factor (EF) is a calmodulin-dependent adenylate cyclase that converts adenosine triphosphate (ATP) into 3'-5'-cyclic adenosine monophosphate (cAMP), contributing to the establishment of Bacillus anthracis infections and the resulting pathophysiology. We show that EF adenylate cyclase toxin activity is strongly mediated by the N-end rule, and thus is dependent on the identity of the N-terminal amino acid. EF variants having different N-terminal residues varied by more than 100-fold in potency in cultured cells and mice. EF variants having unfavorable, destabilizing N-terminal residues showed much greater activity in cells when the E1 ubiquitin ligase was inactivated or when proteasome inhibitors were present. Taken together, these results show that EF is uniquely affected by ubiquitination and/or proteasomal degradation.PLoS ONE 08/2013; 8(8):e74474. DOI:10.1371/journal.pone.0074474 · 3.53 Impact Factor
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ABSTRACT: Bacillus anthracis, the causative agent of anthrax disease, is lethal owing to the actions of two exotoxins: anthrax lethal toxin (LT) and oedema toxin (ET). The key tissue targets responsible for the lethal effects of these toxins are unknown. Here we generated cell-type-specific anthrax toxin receptor capillary morphogenesis protein-2 (CMG2)-null mice and cell-type-specific CMG2-expressing mice and challenged them with the toxins. Our results show that lethality induced by LT and ET occurs through damage to distinct cell types; whereas targeting cardiomyocytes and vascular smooth muscle cells is required for LT-induced mortality, ET-induced lethality occurs mainly through its action in hepatocytes. Notably, and in contradiction to what has been previously postulated, targeting of endothelial cells by either toxin does not seem to contribute significantly to lethality. Our findings demonstrate that B. anthracis has evolved to use LT and ET to induce host lethality by coordinately damaging two distinct vital systems.Nature 08/2013; DOI:10.1038/nature12510 · 42.35 Impact Factor
Article: Small molecule inhibitors of lethal factor protease activity protect against anthrax infection.[Show abstract] [Hide abstract]
ABSTRACT: Bacillus anthracis, the causative agent of anthrax, manifests its pathogenesis through the action of two secreted toxins. The bipartite lethal and edema toxins, a combination of lethal factor or edema factor with the protein protective antigen, are important virulence factors for this bacterium. We previously developed small molecule inhibitors of lethal factor proteolytic activity (LFIs) and demonstrated their in vivo efficacy in a rat lethal toxin challenge model. In this work we show that these LFIs protect against lethality caused by anthrax infection in mice when combined with sub-protective doses of either antibiotics or neutralizing monoclonal antibodies that target edema factor. Significantly, these inhibitors provided protection against lethal infection when administered as a monotherapy. As little as two doses (10 mg/kg) administered at 2 h and 8 h after spore infection was sufficient to provide a significant survival benefit in infected mice. Administration of LFIs early in the infection was found to inhibit dissemination of vegetative bacteria to the organs in the first 32 h following infection. In addition, neutralizing antibodies against edema factor also inhibited bacterial dissemination with similar efficacy. Together, our findings confirm the important roles that both anthrax toxins play in establishing anthrax infection, and demonstrate the potential for small molecule therapeutics targeting these proteins.Antimicrobial Agents and Chemotherapy 06/2013; DOI:10.1128/AAC.00941-13 · 4.45 Impact Factor
Article: Anthrax Lethal Toxin Downregulates Claudin-5 Expression in Human Endothelial Tight Junctions[Show abstract] [Hide abstract]
ABSTRACT: Vascular leakage pathologies such as pleural effusion and hemorrhage are hallmarks of anthrax pathogenesis. We previously reported that anthrax lethal toxin (LT), the major virulence factor of anthrax, reduces barrier function in cultured primary human microvascular endothelial cells. Here, we show that LT-induced barrier dysfunction is accompanied by the reduced expression of the endothelial tight junction (TJ) protein claudin-5 but no change in the expression of other TJ components occludin, ZO-1, ZO-2, or the adherens junction (AJ) protein VE-cadherin. The downregulation of claudin-5 correlated temporally and dose-dependently with the reduction of transendothelial electrical resistance. LT-induced loss of claudin-5 was independent of cell death and preceded the appearance of actin stress fibers and altered AJ morphology. Pharmacological inhibition of MEK-1/2, two kinases that are proteolytically inactivated by LT, showed a similar reduction in claudin-5 expression. We found that LT reduced claudin-5 mRNA levels but did not accelerate the rate of claudin-5 degradation. Mice challenged with LT also showed significant reduction in claudin-5 expression. Together, these findings support a possible role for LT disruption of endothelial TJs in the vascular leakage pathologies of anthrax.PLoS ONE 04/2013; 8(4):e62576. DOI:10.1371/journal.pone.0062576 · 3.53 Impact Factor
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ABSTRACT: Background Signals of danger and damage in the cytosol of cells are sensed by NOD-like receptors (NLRs), which are components of multiprotein complexes called inflammasomes. Inflammasomes activate caspase-1, resulting in IL-1-beta and IL-18 secretion and an inflammatory response. To date, the only known activator of rodent Nlrp1 is anthrax lethal toxin (LT), a protease secreted by the bacterial pathogen Bacillus anthracis. Although susceptibility of mouse macrophages to LT has been genetically linked to Nlrp1b, mice harbor two additional Nlrp1 paralogs in their genomes (Nlrp1a and Nlrp1c). However, little is known about their expression profile and sequence in different mouse strains. Furthermore, simultaneous expression of these paralogs may lead to competitional binding of Nlrp1b interaction partners needed for inflammasome activation, thus influencing macrophages susceptibility to LT. To more completely understand the role(s) of Nlrp1 paralogs in mice, we surveyed for their expression in a large set of LT-resistant and sensitive mouse macrophages. In addition, we provide sequence comparisons for Nlrp1a and report on previously unrecognized splice variants of Nlrp1b. Results Our results show that macrophages from some inbred mouse strains simultaneously express different splice variants of Nlrp1b. In contrast to the highly polymorphic Nlrp1b splice variants, sequencing of expressed Nlrp1a showed the protein to be highly conserved across all mouse strains. We found that Nlrp1a was expressed only in toxin-resistant macrophages, with the sole exception of expression in LT-sensitive CAST/EiJ macrophages. Conclusions Our data present a complex picture of Nlrp1 protein variations and provide a basis for elucidating their roles in murine macrophage function. Furthermore, the high conservation of Nlrp1a implies that it might be an important inflammasome sensor in mice.BMC Genomics 03/2013; 14(1):188. DOI:10.1186/1471-2164-14-188 · 4.04 Impact Factor
Article: Engineering Anthrax Toxin Variants That Exclusively Form Octamers, and Their Application to Targeting Tumors.[Show abstract] [Hide abstract]
ABSTRACT: Anthrax toxin protective antigen (PA) delivers its effector proteins into the host cell cytosol through formation of an oligomeric pore, which can assume heptameric or octameric states. By screening a highly directed library of PA mutants, we identified variants that complement each other to exclusively form octamers. These PA variants were individually nontoxic and demonstrated toxicity only when combined with their complementary partner. We then engineered requirements for activation by matrix metalloproteases and urokinase plasminogen activator into two of these variants. The resulting therapeutic toxin specifically targeted cells expressing both tumor associated proteases, and completely stopped tumor growth in mice when used at a dose far below that which caused toxicity. This scheme for obtaining intercomplementing subunits can be employed with other oligomeric proteins, and potentially has wide application.Journal of Biological Chemistry 02/2013; DOI:10.1074/jbc.M113.452110 · 4.60 Impact Factor
Article: Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages[Show abstract] [Hide abstract]
ABSTRACT: Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin. In rats, the sensitivity of macrophages to toxin-induced cell death is determined by the presence of an LF cleavage sequence in the inflammasome sensor Nlrp1. LF cleaves rat Nlrp1 of toxin-sensitive macrophages, activating caspase-1 and inducing cell death. Toxin-resistant macrophages, however, express Nlrp1 proteins which do not harbor the LF cleavage site. We report here that mouse Nlrp1b proteins are also cleaved by LF. In contrast to the situation in rats, sensitivity and resistance of Balb/cJ and NOD/LtJ macrophages does not correlate to the susceptibility of their Nlrp1b proteins to cleavage by LF, as both proteins are cleaved. Two LF cleavage sites, at residues 38 and 44, were identified in mouse Nlrp1b. Our results suggest that the resistance of NOD/LtJ macrophages to LT, and the inability of the Nlrp1b protein expressed in these cells to be activated by the toxin are likely due to polymorphisms other than those at the LF cleavage sites.PLoS ONE 11/2012; 7(11):e49741. DOI:10.1371/journal.pone.0049741 · 3.53 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Detection of microbial products by host inflammasomes is an important mechanism of innate immune surveillance. Inflammasomes activate the caspase-1 (CASP1) protease, which processes the cytokines interleukin (IL)-1β and IL-18, and initiates a lytic host cell death called pyroptosis. To identify novel CASP1 functions in vivo, we devised a strategy for cytosolic delivery of bacterial flagellin, a specific ligand for the NAIP5 (NLR family, apoptosis inhibitory protein 5)/NLRC4 (NLR family, CARD-domain-containing 4) inflammasome. Here we show that systemic inflammasome activation by flagellin leads to a loss of vascular fluid into the intestine and peritoneal cavity, resulting in rapid (less than 30 min) death in mice. This unexpected response depends on the inflammasome components NAIP5, NLRC4 and CASP1, but is independent of the production of IL-1β or IL-18. Instead, inflammasome activation results, within minutes, in an 'eicosanoid storm'--a pathological release of signalling lipids, including prostaglandins and leukotrienes, that rapidly initiate inflammation and vascular fluid loss. Mice deficient in cyclooxygenase-1, a critical enzyme in prostaglandin biosynthesis, are resistant to these rapid pathological effects of systemic inflammasome activation by either flagellin or anthrax lethal toxin. Inflammasome-dependent biosynthesis of eicosanoids is mediated by the activation of cytosolic phospholipase A(2) in resident peritoneal macrophages, which are specifically primed for the production of eicosanoids by high expression of eicosanoid biosynthetic enzymes. Our results therefore identify eicosanoids as a previously unrecognized cell-type-specific signalling output of the inflammasome with marked physiological consequences in vivo.Nature 08/2012; 490(7418):107-11. DOI:10.1038/nature11351 · 42.35 Impact Factor
Article: Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain[Show abstract] [Hide abstract]
ABSTRACT: Four core structures capable of providing sub-nanomolar inhibitors of anthrax lethal factor (LF) were evaluated by comparing the potential for toxicity, physicochemical properties, in vitro ADME profiles, and relative efficacy in a rat lethal toxin (LT) model of LF intoxication. Poor efficacy in the rat LT model exhibited by the phenoxyacetic acid series (3) correlated with low rat microsome and plasma stability. Specific molecular interactions contributing to the high affinity of inhibitors with a secondary amine in the C2-side chain were revealed by X-ray crystallography.Bioorganic & medicinal chemistry letters 03/2012; 22(6):2242-6. DOI:10.1016/j.bmcl.2012.01.095 · 2.33 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms. Their activation in response to a wide range of intracellular danger signals leads to formation of the inflammasome, caspase-1 activation, rapid programmed cell death (pyroptosis) and maturation of IL-1β and IL-18. Anthrax lethal toxin (LT) induces the caspase-1-dependent pyroptosis of mouse and rat macrophages isolated from certain inbred rodent strains through activation of the NOD-like receptor (NLR) Nlrp1 inflammasome. Here we show that LT cleaves rat Nlrp1 and this cleavage is required for toxin-induced inflammasome activation, IL-1 β release, and macrophage pyroptosis. These results identify both a previously unrecognized mechanism of activation of an NLR and a new, physiologically relevant protein substrate of LT.PLoS Pathogens 03/2012; 8(3):e1002638. DOI:10.1371/journal.ppat.1002638 · 8.06 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: A phase 1 study of a recombinant mutant protective antigen (rPA) vaccine was conducted in 186 healthy adults aged 18 to 45 years. Volunteers were randomized to receive one of three formulations of rPA (formalin treated, alum adsorbed, or both), in 10- or 20-μg dosages each, or the licensed vaccine, AVA. Three injections were given at 2-month intervals and a 4th 1 year after the 3rd. Vaccinees were examined at the clinic once following each injection, at 48 to 72 h postinjection. Adverse reactions were recorded in diaries for 7 days. Sera were collected before each injection and 1 week after the 1st, 2 weeks after the 3rd and 4th, and 1 year after the 4th. Serum anti-PA IgG was assayed by enzyme-linked immunosorbent assay (ELISA) and toxin neutralization assay (TNA). All formulations at both dosages were safe and immunogenic, inducing booster responses, with the highest antibody levels following the 4th injection (354 to 732 μg/ml). The lowest levels were induced by the formalin-only-treated rPA; there was no statistical difference between levels induced by alum-adsorbed and formalin-treated/alum-adsorbed rPA or by the two dosages. The antibody levels declined in all groups during the 1-year intervals after the 3rd and 4th injections but less so during the 2nd year, after the 4th injection (fold decreases were 10 to 25 versus 3.4 to 7.0, P < 0.001). There were too few AVA recipients for statistical comparisons, but their antibody levels followed those of rPA. Anti-rPA measured by ELISA correlated with TNA titers (r = 0.97). These data support studying alum-adsorbed rPA in children.Clinical and vaccine Immunology: CVI 12/2011; 19(2):140-5. DOI:10.1128/CVI.05556-11 · 2.37 Impact Factor
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Kat Graham
'The Vampire Diaries' Recap: No Vampires Allowed
Television recap of "The Vampire Diaries" season 6 episode 1, discussing the repercussions from last season's finale. After the fallout with Bonnie and Damon stuck on the other side, the Mystic Falls Gang each grieve in different ways.
CW Celebrities' Must-See Fashion This Month
We're taking a look at CW celebrities' fashion this past month.
'The Vampire Diaries' Poster Gives Clues About Season 6
By the looks of the Mystic Falls crew caught mid-stride with "All spell breaks loose" as the poster's tag — drama is heavily foreshadowed in the season 6 poster for "The Vampire Diaries."
CW shows to be featured at San Diego Comic Con
Fanbolt.com is reporting that for this year's San Diego Comic Con, Warner Brothers is putting together a number of panels featuring CW shows such as "Arrow," "The Vampire Diaries," "Supernatural," "The Flash," "The 100." […]
Kat Graham's Best Dressed
Kat Graham's Best Dressed. Glamour, Kat Graham knows it.
2014 Oscars: How CW Celebs Celebrated
Oscars 2014: How CW Celebs Celebrated. Now that we have digested the best and worst moments from the Oscars, let's get to what's really important… how did our favorite CW celebs celebrate the Oscars?
Crush on Kat Graham's Outfit
Crush on Kat Graham's Outfit. "The Vampire Diaries" Kat Graham did it again. The actress/singer mastered fierce fashion but this time in a soft way.
Crave These CW Celeb Shades
Crave These CW Celeb Shades. My spring fever has been boiling ever since I laid eyes on Katie Cassidy, Kat Graham and Phoebe Tonkin's sunglasses.
Who Wore Red Better: Kat Graham or AnnaSophia Robb?
Who Wore Red Better: Kat Graham or AnnaSophia Robb? "The Vampire Diaries" co-star Kat Graham and "The Carrie Diaries" star AnnaSophia Robb celebrated New York fashion week the right way, walking the runway.
February Fashion: Kat Graham & Katie Cassidy Approved
February Fashion: Kat Graham & Katie Cassidy Approved. Before you know it February will be here and let's face it your wardrobe is probably hibernating (Mine is, I've been following an assembly line full of dull colors, big sweaters and comfy pants). It's time for a change. Freshen up your wintery blues and fight those fashion scares with these items you MUST try


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linen flutter sleeve tee
Pure linen knit delivers an airy feel, billowy movement and a semi-sheer finish with organic texture. Cut in an easy shape with fluttery sleeves, it makes for a tee that's uniquely smart and effortlessly feminine.
- Deep V-neck, scoop back
- Cap flutter sleeves with rolled trim
- Easy fit, hi-lo hem
- Textured, semi-sheer finish
- Linen
- Hand wash
- Imported


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1987 Audi 5000 • 175,000 miles
1987 Audi 5000CS Turbo. 175,000 miles. My brake lights don't work, fuse is good, bulbs are good, what could be the problem? (Where is the fuse for the actuator for the shifter?)
October 12, 2010.
October 12, 2010.
Check the brake light switch. It might work the lights and the shift lock-out.
Oct 12, 2010.
Oct 12, 2010.
My brake lights went out on my 1985 ford ltd, fuses & bulbs are good. What else can it be? Also a few months back my hazard lights, and dash lights went out too. The fuses are all good...
2 answers • 1985 Ford LTD • 160,000 miles
When I'm parked I can press on my brake pedal and the brake lights come on. When I'm driving, if I don't press hard on my brake pedal, my brake lights don't seem to come on. If I press ...
1 answer • 1998 Plymouth Breeze • 140,000 miles
The brake lights on my 2001 Jeep Grand Cherokee are out completely. Tail lights and headlights work. The brake lights were staying stuck on when my headlights were on, but now the top ...
1 answer • 2001 Jeep Grand Cherokee • 120,000 miles
2002 chev cavalier no lower brake lights uppers work fine. Replaced bulbs, checked fuses OK all other lights work as suppose to.
1 answer • 2002 Chevrolet Cavalier • 178,000 miles


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Mitch's Feed
How many more passwords can we change? The eBay data breach: Now what? http://t.co/1ja5CnnFQQ
Answer your phone with care: Junk calls using threats, lies to dupe consumers http://t.co/K6TiRMwJkd
How to get compensated for air travel delays
May 15 (Reuters) – Last summer, Mark Wilson waited in a Rome
airline terminal for a connecting flight to London on his way
home to New York. And waited. And waited. By the time he arrived
in London four hours late, the final New York-bound flight had
Wilson was offered a room at an airport hotel, which he
declined. He was also due a $550 cash penalty by U.S. law but
says he never knew about the rule. The money sat unclaimed for
more than two months, until he used the service Refund.me to


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» Print Recipe
Ben O'Donoghue whips up a local version of this salmon recipe while in The Grampions.
To make the sauce heat the olive oil in a pot. When hot add the olive and gently fry until fragrant (1-2 minutes). Then add the garlic, anchovy and capers and fry for another 1-2 minutes.
When the flavours have blended add the cream and remove from the heat and stir well.
Add the chopped herbs and lemon juice. Season the fish on the skin side and place into a non-stick pan skin side down. Cook on a medium heat until the fish is halfway cooked. (The flesh will change to a whitish color as it cooks) turn the fish over and turn of the heat and allow to rest in the pan.
Boil the asparagus at this point until tender. Drain and divide between four plates. By this time the salmon will be perfectly cooked to medium. Spoon the sauce between each plate and garnish with a little extra chopped herbs.
» Metric Converter
Sauvignon Blanc, Riesling and Semillon are the best wines to pair with Salmon with Warm Olive Sauce.
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Recipe by Ben O'Donoghue
Recipe by Ben O'Donoghue from The Best In Australia
We offer fresh cut bank instrument for lease, such as BG, SBLC, MTN, Bank Bonds, Bank Draft, T strips and others. Leased Instruments can be obtained at minimal expense to the borrower compared to other banking options. This offer is opened to both those and corporate bodies. We are RWA ready to close leasing with any interested client in few banking days, if interested do not hesitate to contact us via email: All relevant business information will be provided upon request. If Interested kindly contact me via Email:~ Contact : Mr. Petrovic Dorde Email: firstname.lastname@example.com Skype ID: petrovic.dorde
» 7h ago


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The 2015-16, 2016-17, 2017-18 KYRC contract plan outlined in this document was developed in collaboration with the Early Intervention parent support group, parents involved in the Peer Support Partner program coordinated through the KYRC, and staff from LRC's Early Intervention Unit.
13th Annual Housing Rights Summit: Creating Safe and Healthy Communities
The Housing Rights Center presents its annual summit, which will feature panels with discussions on bed bugs, lead poisoning, legal rights of tenants in slum housing, civil rights and housing, domestic violence, and more.
The summit is an educational conference aimed at addressing the wide‐range of civil rights and social justice issues impacting communities throughout California. The conference brings together community advocates, attorneys, government officials, organizers and members of the concerned public to share information and resources, build and strengthen partnerships among community allies, and exchange ideas and strategies on how to overcome the core challenges facing low‐income communities.
Seating is limited. There is a registration fee of $25, which includes breakfast, lunch and educational materials.
For questions or concerns, contact Amy Ly, Outreach Coordinator, at 213.387.8400, x. 19 or email@example.com.
Ronald F. Deaton Auditorium
100 W. 1st Street
Los Angeles, CA 90012


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Vocabulary Word
Word: precipice
Definition: cliff; dangerous position; Ex. on the edge of the precipice
Definition: cliff; dangerous position; Ex. on the edge of the precipice
Sentences Containing 'precipice'
But all my care and pains were unavailing, for my master made the discovery that I was not a man, and harboured the same base designs as my servant; and as fortune does not always supply a remedy in cases of difficulty, and I had no precipice or ravine at hand down which to fling the master and cure his passion, as I had in the servant's case, I thought it a lesser evil to leave him and again conceal myself among these crags, than make trial of my strength and argument with him.
His association with Django Bates has led to many diverse projects away from the jazz environment they normally occupy with Human Chain and Delightful Precipice.
In an attempt to run over the summit of the Rigi, the travelers crash at the bottom of a precipice.
It is protected on one side by a precipice and on the others by a single ditch, in depth and in width; a vallum of large dimensions.
Other islands in the immediate vicinity include Culbertson Island, Mark Island, McAllister Island, Mitchell Island, and Precipice Island.
The inner coast around the caldera is a sheer precipice of more than 300 m drop at its highest, and exhibits the various layers of solidified lava on top of each other, and the main towns perched on the crest. The ground then slopes outwards and downwards towards the outer perimeter, and the outer beaches are smooth and shallow.
The most tremendous waterfall in our country is Niagara Falls, which every minute hurls millions of gallons of water down a 163 foot precipice.
The prow of the boat is partially unbroken, and is drawn just balancing upon the monster's spine; and standing in that prow, for that one single incomputable flash of time, you behold an oarsman, half shrouded by the incensed boiling spout of the whale, and in the act of leaping, as if from a precipice.
There was a dark gloom in my solitary chamber, when I at length returned to it; but I was tired now, and, getting into bed again, fell--off a tower and down a precipice--into the depths of sleep.
This flapper is likewise employed diligently to attend his master in his walks, and upon occasion to give him a soft flap on his eyes; because he is always so wrapped up in cogitation, that he is in manifest danger of falling down every precipice, and bouncing his head against every post; and in the streets, of justling others, or being justled himself into the kennel.
This had to change and by the time of the Treaty debates in 1922 which established the Irish Free State he said he preferred 'a slippery slope to a precipice' and voted in favour.
More Vocab Words::: ingratiate - become popular with; bring (oneself) in favor of another; Ex. ingratiate himself with the boss
::: disapprobation - disapproval; condemnation
::: consequential - self-important; significant; consequent; following as a result; Ex. consequential air; CF. subsequent
::: eerie - weird; causing fear because strange
::: heterogeneous - dissimilar; mixed; not homogeneous; consisting of dissimilar elements or plants
::: provision - act of providing; something provided; preparatory measure; provisions: necessary supplies (esp. food); stipulation; condition in an agreement; Ex. According to the provisions of the agreement
::: ultimatum - last demand; last warning; last statement of conditions that must be met; Ex. They have ignored our ultimatum.
::: ethos - underlying character of a culture, group, etc.; character or ideas peculiar to a specific person, group, or culture; Ex. the company ethos
::: rendezvous - meeting place; meeting at a set time or place; V.
::: underscore - underline; emphasize


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Credits & Info
- Uploaded
- Jan 30, 2012 | 9:13 PM EST
- Daily 2nd Place February 1, 2012
If you liked this, check these out!
Author Comments
Rated 5 / 5 stars
so...scared....*cries in corner*
I cant even get passed the first two minutes...
dear god...Its like...it's..........................
Rated 5 / 5 stars
GAAAAAAAAHHH its cool and all but this made my stomach go all the waay up and nearly gave me night mares!!!!!!!
Haha, mission success. Thanks. >:)
Rated 5 / 5 stars
Wonderful story.
The quality of the story, as well as the storytelling was phenomenal. To complement this, fitting music and sound effects were used to put emphasis on the mood of the story.
The art style was interesting, and it fit very well. It appeared to be hand drawn, but you may correct me if I'm wrong.
Lastly, the voice acting was superb as well. Although the audio quality wasn't perfect, the voice acting completely made up for this, as it was interesting and not without emotion.
Great job on this, especially for a first animation. :)
Rated 5 / 5 stars
whew, that was creepy. it was hard to hear the narrater sometimes, sounds like you might need a better microphone. it was awesome though, loved the animations style. :D
Rated 5 / 5 stars
Absolutely Love It..
This is really great work. Dark, brooding, and draws you in. Definitely strikes a personal chord... For that, 10 stars!


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The town voted to keep the school closed in a reconsideration vote Tuesday.
The public hearing will be held three days before the town votes on the fate of the school.
The history of Town Meeting Day in Vermont dates back to 1762, when the first town meeting was held in Bennington, before Vermont's creation.
Cornwall will now vote for a third time to take a clear stance on proposed terms from Vermont Gas on their pipeline.
Voters are waking up to a previously failed idea that passed with a twist.
On Town Meeting Day people said 'yes' to a new town office complex; but now some people want to reverse that decision.
Some say "no" to Waterbury's pending municipal office building.
People in Vergennes headed to the polls to cast a vote on the Vermont Gas Systems pipeline. A 'no' vote does not guarantee that the pipeline won't come through Addison County. But voters say at least their opinions will be heard.


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China Science Festival to host "1001 Inventions and the World of Ibn Al-Haytham"
1001 Inventions Bahrain anchored 'Zedni Elman'
Cairo University joins 1001 Inventions partners in Egypt
Blockbuster exhibition will be anchor attraction at 'Zidni Ilman'
VIP Audience Celebrates Central European Premiere of Muslim Heritage Exhibition
Award-winning production arrives at the Scientific Center of Kuwait
High profile launch for new global campaign
The Scientific Center of Kuwait & Kuwait Foundation for the Advancement of Science
UNESCO partners with 1001 Inventions for 2015 campaign
National Educational Programme to launch in Egypt
Professor George Saliba Lectures
George Saliba has been a Professor of Arabic Science at the Department of Middle East and Asian Languages and Cultures, Columbia University, New York, United States, since 1979.
Having gained a Master of Science degree in Semitic Languages and a doctorate in Islamic Sciences from the University of California, Berkeley, he is the recipient of numerous awards and honours including the History of Science Prize given by the Third World Academy of Science in 1993 and the History of Astronomy Prize in 1996 from the Kuwait Foundation for the Advancement of Science.
On his website he describes himself as studying 'the development of scientific ideas from late antiquity till early modern times, with a special focus on the various planetary theories that were developed within the Islamic civilization and the impact of such theories on early European astronomy." (*)
1. London Lecture:
Professsor George Saliba Lecture at The School of Oriental and African Studies (SOAS), University of London, co-ordinated by 1001 Inventions.
Photos from the Lecture:.
Professor Salim T S Al-Hassani and Professor George Saliba.
Other lectures:
Photos from 1001 Inventions Birmingham Exhibition:.
please click the pictures to enlarge.
Dr. Ibrahim Sheikh, Prof. George Saliba, Prof. Salim Al-Hassani


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Thursday Sep 26, 2013
The Java Community Keynote presented inspiring technologies that reflected the hard work of the Java ecosystem.[Read More]
At the Java Demogrounds: The Internet of Things at JavaOne 2013
By Janice J. Heiss on Sep 26, 2013
The Internet of Things was everywhere at JavaOne 2013.[Read More]
Session Report: DataFX: The Best Way to Get Real-World Data into Your JavaFX Application
By Janice J. Heiss on Sep 26, 2013
Johan Vos and Hendrik Ebbers explained how to make use of the free and open source DataFX project.[Read More]
Recent Posts
- JavaOne Latin America Highlights
- Meet the JavaOne Java EE Track Committee: David Heffelfinger
- Discover the Java Hub
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- Java EE Track at JavaOne
- Announcing JavaOne Keynote Speakers
- JavaOne Call for Proposals Deadline Extension
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- JavaOne 2015 Call for Proposals Open


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11 Copycat Recipes for Baking Ingredients: Recipes for Homemade Bisquick & More
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Homemade Bisquick
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- 12 cups sifted flour
- 6 tb baking powder
- 6 ts salt
- 3 cups shortening
Yield: 4 Quarts. Sift dry ingredients together 3 times; cut in the shortening; stir and mix until you have a granular texture, like cornmeal; put mixture in glass jars and cover lightly; makes about 4 quarts.
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Sep 27, 2012
I would like to use this mix, can you offer more recipes using it? What about making plain biscuits or a short bread or coffee cake? Thank you.
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You could go to: [http://www.recipelion.com/?task=search&search_term=Bisquick+Recipes], here on RecipeLion for some recipes using Bisquick.
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Child Killed in Burlington Township Crash
A 9-year old girl died following an accident in Mt. Holly Sunday night.
A 9-year old girl died following an accident in Mt. Holly Sunday night.
A driver at the wheel of a tractor trailer lost control of the rig today in Runnemede, taking out nine utility poles and leaving local residents without power.
A speeding driver lost control of his sport utility vehicle on the Black Horse Pike in Egg Harbor Township and crashed just before midnight last night. The vehicle landed on its roof sending the driver to the hospital and shutting down traffic for two hours.
An investigation is underway in Pine Hill, Camden County after a driver, reportedly taken off-guard by this morning's icy road ways, crashed into a New Jersey Transit bus.
I'll admit, there are times that I've put the 'pedal to the metal'. After I saw this ad, everything changed.
Two students on the bus home from Toms River Intermediate School were taken to a local medical center after the bus collided with a vehicle on Old Freehold Road today.
A crash involving two vehicles and a New Jersey Transit bus happened in Atlantic City a short time ago, sending several people to the hospital.
A school bus carrying senior citizens was involved in an accident this morning in Glendora, Camden County.
Several people, including a young child, were injured today after a serious accident on route 47 near Fulling Mill Road in Middle Township, Cape May County.
Authorities say 10 people, including six children, have been injured in rollover crash on the Atlantic City Expressway.
SoJO Traffic reports one eastbound lane has been reopened on the Atlantic City Expressway following this afternoon's fatal accident.


text:
Leaders remain hopeful Warwickshire will join new West Midlands Combined Authority
Long-running Ricoh Arena dispute will be revived in the Court of Appeal on Wednesday as Sky Blues owners try to secure appeal against judicial review defeat
Cases before Coventry Magistrates Court on June 24
A milder few days ahead but the heat could return for the weekend
Organisers hail huge success of free music event, with police making just one arrest over the weekend
Coventry and Warwickshire news plus weather, traffic and sport on Friday, July 3
Coventry and Warwickshire area news plus weather, traffic and sport on Monday, July 6
New authority to cover four million people - and could eventually expand to the whole of Warwickshire
Organisers are still searching for car owners to get involved in the event which is being resurrected after being axed for the first time in 30 years
Closures will be in force for next two weeks as work to transform notorious Coventry roundabout continues
Desi Fusion was followed by TV food guru Russell Norman in The Restaurant Man
The phone which was lost in the Isle of Wight was seized after a man tried to pawn it in Coventry Cash Converters
Brian Banda will appear before Coventry magistrates charged with GBH after allegedly failing to disclose he was HIV positive for three years
Lightning strikes kept us all awake on Friday night - and there could be more to come during the final day of Godiva Festival
Police are looking to speak to a man after a theft on June 25 in Lloyds Chemist in Earlsdon
The best of the pictures from our readers, and Coventry and Warwickshire residents, as the weather turned wild last night
Fun Lovin' Criminals performed last night and Liverpudlian band The Wombats are today's headliners
Roisin McCourt's girl group, Roisin and The Contractions, will take to the stage at the Godiva Festival
'Pinch point' work around Woodway Lane in Walsgrave will be put on hold for weeks while BT fixes mistake
Trio chat to the Telegraph before headlining the main stage at the War Memorial Park on Friday night
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Videos tagged "policy"
Wireless 2010: Predictions for the year ahead - MobileMonday Toronto01:58:47
103 Plays / 1 Likes / 0 Comments
Thoughts/Predictions of the wireless industry for 2010 •mobile devices •applications •storefronts •social media •market forces, government policy, capital markets, Canadian mobile industry, global environment with panelists: Michael Urlocker Director, Equity Research Technology Hardware Analyst GMP Securities L.P. Krista Napier Senior Analyst, Canadian Competitive Intelligence and Emerging Technology IDC Canada Ronald Gruia Principal Analyst, Telecom Frost & Sullivan Moderated by Jeff Mucci, Arden Operating Company, Managing Partner RCR Wireless, Publisher Telecomcareers, CEO+ More details
DESIRE Meeting Almeria 2011 - Policy Panel Discussion01:57:31
90 Plays / 0 Likes / 0 Comments
Panel discussion with 4 Spanish policy related people connected to Spanish environment and desertification related issues. The discussion was held during the 5th plenary meeting of the DESIRE project (www.desire-project.eu), on October 6th 2011. This 2-hour discussion was led by Dr. Karen Witsenburg, team member of BothENDS. The Spanish Panel consisted of: 1. Leopoldo Rojo (member of the UNCCD focal point for Spain) 2. Juan Puigdefabregas (retired professor in Desertification and degradation) 3. Miguel Angel Fernandez Carrillo (Works at the office for knowledge transfer and training of the regional ministry of agriculture in Murcia) 4. David Ucles-Aguilera (Works at the environmental part of an agricultural research station and is based in Almeria) (c) DESIRE project and Partners. production: Erik van den Elsen - ALTERRA, NL The audience consisted of DESIRE project partners.+ More details
Update from Fukushima with Tetsunari Iida01:56:56
18 Plays / 0 Likes / 0 Comments
OSEA and York University's Sustainable Energy Initiative's recent webinar/live presentation with Tetsunari Iida, Director of Japan's Institute for Sustainable Energy Policy.+ More details
Biochar Protocol Development webinar: Biochar Science, Feedstocks and Technology01:56:50
127 Plays / 1 Likes / 0 Comments
As part of our effort to develop a greenhouse gas emission reduction offset quantification protocol for biochar projects, Biochar Protocol Develoment held a webinar with members of the biochar community June 15, 2010, titled Biochar Science, Feedstocks and Technology. For more information, visit www.biocharprotocol.org+ More details
Public Problems, Private Money: Can Global Philanthropy Make the Right Kind of Difference in Today's World?01:55:22
28 Plays / 0 Likes / 0 Comments
Georgetown University's Center for Public and Nonprofit Leadership (CPNL) presents the 2012 Waldemar A. Nielsen Issue Forum in Philanthropy: Public Problems, Private Money: Can Global Philanthropy Make the Right Kind of Difference in Today's World? This event was held on February 29th at Georgetown University in Washington, DC and was cosponsored with the Walsh School's Institute for the Study of Diplomacy. The speakers are experts in philanthropy, international development and human rights. Kavita Ramdas, CPNL's 2012 Waldemar A. Nielsen Fellow and Former President and CEO of the Global Fund for Women, provided opening remarks. Our distinguished panel also included Lisa Mensah, Executive Director of the Initiative on Financial Security at the Aspen Institute and Raymond C. Offenheiser, President of Oxfam America. Stanley Katz, Professor of Public and International Affairs at Princeton University and renowned specialist on philanthropy and nonprofit institutions, moderated this lively discussion.+ More details
Social Assistance Review Webinar: Understanding the Options01:53:40
18 Plays / 0 Likes / 0 Comments
Recorded on February 17, 2012 - The Commission for the Review of Social Assistance in Ontario released its second discussion paper on February 3, 2012 and is asking for feedback on a number of approaches it could take in reforming social assistance. The options could have far-reaching implications for people on low incomes. In this webinar, Jennefer Laidley of the Income Security Advocacy Centre (ISAC) will provide an overview and initial analysis of the various options and key issues in the discussion paper.+ More details
Urban Laboratory Annual Lecture 2012: Margit Mayer01:53:06
15 Plays / 0 Likes / 0 Comments
CITY Journal and UCL Urban Laboratory annual lecture from October 2012. The keynote speech is by Margit Mayer on 'The Urban Question Under Conditions of Globalization'. You can read more about it here: http://www.ucl.ac.uk/urbanlab/news/MargitMayerarticle+ More details
Science and Society 2013 - Influencers Panel01:50:47
7 Plays / 0 Likes / 0 Comments
October 23rd, 2013 Title: Panel of influential decision-makers discussing results of the Science and Society 2013 symposium Chair: Yves St-Onge Vice-President, Public Affairs and Marketing, Canada Science and Technology Museums Corporation Panelists: Scott Findlay Associate Professor, Department of Biology, University of Ottawa Evidence for Democracy Pat Mooney Executive Director, ETC Group Louise Vandelac Professor, Department of Sociology, Université du Québec à Montréal Denise Amyot President and CEO, Association of Canadian Community Colleges+ More details
Patent Law and Policy Conference 201001:50:38
29 Plays / 0 Likes / 0 Comments
Full conference video+ More details
Webinar on the Science of Policy Communication Part II01:49:38
16 Plays / 0 Likes / 0 Comments
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Tags are keywords that describe videos. For example, a video of your Hawaiian vacation might be tagged with "Hawaii," "beach," "surfing," and "sunburn."


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|Assembly Information
|Flat packed for easy home assembly - Instructions and fixings supplied
|Assembly Required
|88 x 29 x 60cm
|Oak Effect
|Fixings Included
|Product Type
|Display Units
|Tables, Shelving & Units
Delivered from £2.95
by Saturday 11 July
by Saturday 11 July
|Standard: 3-5 days
|Next day
|Named day
|Named day and time
|More delivery info
Returns for UKIf for any reason you are not satisfied with your George Clothing or George Home product, simply return it within 100 days with proof of purchase for an exchange or refund. George branded products only. Excludes watches, jewellery, hair accessories, part assembled flat pack furniture and mattresses. The 100 Day Guarantee only applies to George branded products. Please refer to our terms and conditions for details of our returns and refund process for non-George branded products. Your statutory rights are not affected. UK Mainland stores only. Excludes franchises.
6 Questions & 4 Answers
Asda Q&A is a customer to customer community forum, and as such Asda does not endorse any customers ideas or advice. If you are a Wine Shop customer Asda may respond to questions posted when appropriate to do so regarding product details. If you have a customer service query you can contact us here. Thank you.
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is unit going to be reduced any further as iv got everything in that range an need another unit
Gender: Female
0 answers
what size tv will the unit hold ?
Gender: Female
Additional information about fitzy83 could not be loaded.
Kent, UK
Gender: Male
Additional information about charliefromkent could not be loaded.
Answer:We did not wall mount our but it did come with fixings for that. Personally I think it might be a bit heavy for wall mounting.
Lanivet, Bodmin, Cornwall PL30, UK
Gender: Female
Additional information about KernowCousin could not be loaded.
Answer:It has a small bracket to steady it against a wall but too heavy to hang on the wall
Dundee, Dundee City, UK
Gender: Female
Additional information about Sal50 could not be loaded.
Kent, UK
Gender: Male
Additional information about charliefromkent could not be loaded.
Answer:Yes the pack contains two units which you can use separately or put together to form the square/cube type shape.
Lanivet, Bodmin, Cornwall PL30, UK
Gender: Female
Additional information about KernowCousin could not be loaded.
Answer:Yes and you can put them together as a box or as a tv type unit
Dundee, Dundee City, UK
Gender: Female
Additional information about Sal50 could not be loaded.
0 answers
Dimensions when assembled
The picture shows the two L shapes put together to form a cube. What are the dimensions of this shape put together, not just the L shape on its own.
Additional information about SianyD could not be loaded.
Rated 4.1 out of 5 by 62 reviewers.
Rated 4 out of 5 by Craftyann The products fine The directions were a nightmare they have all the component parts listed 1 to 6 then used 2 sixes in build up of course you don't realise this until you start building. The directions show screws to the outside dowels to the inside, it's the other way about. They have you building it from the small side down, it's so much easier to build the coffee table part first and then put the box peice on top. They don't tell you you have to put the box peice at a specific ideas there is a slightly smaller side. We took 4 hours to build the first one, 10 minutes to build the second. 18 April 2015
Rated 5 out of 5 by elli11 read instruction properly then no probs i saw this item when on a birthday visit to leeds couldnt wait to get back and order on line . all visitors have remarked and asked where purchased have been very suprised at cost. looks far more expensive, im very pleased.instructions were clear to follow and read through twice and experienced no probs fitting together . 03 October 2012
Rated 2 out of 5 by Sal50 Not good quality but ok for the money I know this unit doesn't cost much so I wasn't expecting great things. The manufacturers need to rewrite the assembly instructions as they are wrong from the very first step so don't put the dowels where they tell you to....put them in the next hole along. Unit finish is actually paper with a wood effect print so damages really easy. However if you can build it without damaging it and keep it in a corner out of harms way then it does look good. 25 April 2014
Rated 3 out of 5 by Partygirl1xoxo Nice but not for me!! I bought this product to fit in a space i have in the living room. The measurements were.. 88/29/60.. My space i had measured 78. So i expected it to fit it. As i thought it would be 88 high and 60 width! I was soo wrong. The measurements they gave are for the individual L shape not for when its completely built together as shown in photo! So sadly as it was built i cant return it.. So had to give it away! Very disappointed as i did like it!! 14 August 2013
Rated 5 out of 5 by sparkles0314 Recommended! Was a bit concerned after reading previous comments of the quality, but got to say mine was absolutley fine. Its fitted together with no probs and being the flat pack queen builder in our household it was one of the easiest ive built. Would definatley recommend this as a reasonably priced bit of furniture that actually looks more expensive in the flesh! Looking forward to ordering the tv unit and corner bookcase v.soon :) 10 August 2013
Rated 3 out of 5 by PAngry Product is just ok nothing like what it looks like The shelves are ok although I think the image looks much better than the product in reality. The instructions that are provided are really poor. And to top it all off, I personally dont think the nails etc that were provided are actually the correct hardware that should be provided to to put this piece together. PS: Just to clarify I had a male friend this piece so I dont think the problem is with me being a female 13 January 2012
Rated 5 out of 5 by sharnie really happy wiv this i love this item, really modern, really quick del, and simple to build, looks gr8 25 September 2012
Rated 5 out of 5 by Fussy247 Just what was needed We searched long and hard to find a unit that would fit a specific place in our living room after a makoever. This fitted the bill. We think it is excellent value for money and looks extremely good in our newly decorated room. Family and friends have commented on how well they look and I have recommended them to others. 23 December 2012
Rated 5 out of 5 by elephant1234 Ancona L units in Oak this product was delivered the very next day. We are very pleased with this product-they were easy to assemble and are excellent value for money. we will be buying 2 more after Christmas. we have them the way up in the picture but of course they could be turned the other way for tall vases etc. They are a really good match with our oak table we bought beforehand and guests have commented on their quality and design. 08 December 2012
Rated 1 out of 5 by xbeetlebabeonx L Units wanted this product for some time , read the reviews which were not bad, and decided to take the chance as other people who had brought this product had real bad problems with screws, when they arrived myself and daughter exclaimed the contents, and i was very disappointed scratches , dents and not a very good finish on edges, i have since sent this product back and hope to get a full refund 23 June 2012
Rated 3 out of 5 by Tazz247 Disappointed Overall, the units are good and match the other furniture I have. My main issue is that there are holes in the side of the unit when assembled which are covered with plastic caps, making the furniture look like it came from the 70's. Also, one of the pieces did not have holes drilled properly and so couldn't be assembled completely. Typically, it was the last piece to be connected and I couldn't face dismantling the whole thing to return it to Asda. 24 February 2015
Rated 5 out of 5 by Sandersons Great! Little shorter/slimmer then originally realised. However, it's a great product and we are considering buying another! They are easy to assemble and a lot sturdier then we thought they would be! Also, you can move the 2 pieces around and have them however YOU want! We have them in 2 separate positions next to each other and they look great! We even got a compliment on how unique they looked! Highly recommend! 01 May 2015
Rated 5 out of 5 by Sunsetgirl Great little unit Bought the L unit in oak love the fact that you can change the style of it when you want and it gives a different look, was easy to assemble and the price was great it looks as though it cost more, like it so much I'm thinking of buying another one for my dining room. Would recommend to all. 10 March 2013
Rated 3 out of 5 by Alibongo1 Really nice but a few problems They look nice but are a pain to put together and the implement provided for doing so bends out of shape before you can finish the job. The veneer also chips easily. That being said, so long as you are aware of this, once they are put together they 'look' good quality and modern and chunky 03 March 2013
Rated 5 out of 5 by thea24 Really impressed. We ordered this to take our tv and to rearrange our living area. We were impressed with how easily the instructions were to read, and how easily the units went together. A single ''L' shape is easy to move but is really stable when put together and has items on or in it. Would recommend 30 April 2015
Rated 4 out of 5 by WeeRosey L is for Love I recently bought these online and they were delivered on time.They were a little difficult to assemble,but the right tools are necessary(1 boyfriend and a ratchet screwdriver) The shelves look great and are very modern and stylish and I got them on sale too,so L really is for Love. 20 September 2012
Rated 5 out of 5 by mich111111 Brilliant piece of furniture I love this unit! so good because you can set it out different ways, easy to put together, good sturdy wood, great value for money looks more expensive than it is. I bought a second one a week after the first one as i liked it that much i decided to use it as a tv unit aswell 26 December 2013
Rated 5 out of 5 by Homzi Best quality This L unit is the best one i have seen. It looks great in my room. I have bought all of the Ancona sets and they are all of a high quality and I would recommend these to anyone. Once they have been built up They look great I could not be more pleased with purchasing theses. 31 January 2013
Rated 5 out of 5 by granto4 very good purchase collected my L units on tue 16-9-13 very pleased with this lovely piece of furniture.We built it up easily,they stand at each side of my tv unit as I have my side lamps on them. The units together looks fantastic,would definetly buy more of this range,very happy shopper. 19 September 2013
Rated 4 out of 5 by Brange Good Buy I bought this along with the matching tv unit for my teenage son's bedroom.It was really easy to put together and looks really good!I didn't put the plastic covers over screw fittings as I thought they looked better exposed.Overall pleased with this item. 05 March 2013
Rated 5 out of 5 by smlux78 Great Look - great Value for money Easy to assemble, look great we have 2 sets (i.e. 4 "L" shapes in total) We have 3 together as shelves and the 4th is separate on it own with our phone and broadband hub on it standing tall. Their contemporary shape gives the lounge a really nice look. 04 August 2013
Rated 5 out of 5 by bazaman67 Top quality purchase. Really nice shelving unit with versatile system so shelves can be placed in such a way that the appearance can be altered to suit personal preferences. Overall a lovely unit which looks far more expensive than its price tag (we bought it in the sale). 06 January 2013
Rated 5 out of 5 by desbrenda very good quality no problems assembling this product. i read the reviews before purchase ,and no snags at all. asda in my opinion has taken on board the previous comments and learnt. the screws are very good quality. all the holes line up. very good product asda 31 August 2013
Rated 5 out of 5 by netbowler Ancona L shaped units Bought these to go either side of chimney. Fitted perfectly and along with ornaments it housed set top box and dvd player side by side. Worth noting that if assembled as pictured, the unit is 86 cm high. Good value and looks. 02 March 2013
Rated 4 out of 5 by oldgitious looks fantastic easy to put together but did need a bit of muscle to tighten some of the screws. the pictures on the instructions were different in places to the actual wood but easy to get round. very pleased with end product. 04 September 2013
Rated 5 out of 5 by heather011 L shape units purchased in the sale-which made them excellent value for money. good solid units and they look great. easy to assemble and can be arranged together in a few different ways to get a variety of display units. 05 February 2015
Rated 5 out of 5 by nort reallyy good item modern/and neat looking smashing item needed to fill a space in house, also great to display books/candles/photos just about anything also very pleased with asda direct communication and delivery made very easy Grrrreat 08 December 2012
Rated 5 out of 5 by Gymboy Great made really modern bedside cabinets! Got these for my Neice,to bring her Bedroom up to the way she wanted it!! she was delighted, as was I at how simple they were to construct,and how great they looked!! worth every penny and more!! 13 November 2014
Rated 5 out of 5 by 7yFSABJ Slick purchase, slicker delivery Nice and easy buy from the website and the ability to choose the required delivery slot was spot on, as it allowed me to plan ahead for that day and decide exactly when I needed to be in. 06 November 2014
Rated 3 out of 5 by the58loch OK for the price We have a similar set of shelves purchased from Next and the difference in price reflects the quality. Overall the shelves are fine and as used in a spare room they will do the job . 16 June 2012


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I've been getting a lot of FriendFeed notifications about new people subscribing to my feed. Based on anecdotal comments from people I have talked with, it appears I am not alone and that makes me wonder what is happening that is suddenly causing a bump in activity. Could it be Facebook's own efforts to do something similar raising awareness?
FriendFeed is like Facebook's news feed. But it's more of a dynamic conversation among close friends about what they're up to all over the web — and not so much a social network.
[From Friendfeed, the best software for conversations, raises round and launches publicly » VentureBeat]
More on this topic (What's this?)
Google Is Facing A Strong Threat To Its Core Digital Ad Market From Facebook (Green World Investor, 5/27/15)
Facebook's Internet.org stirs up net neutrality fears in India (Telecom Ramblings, 5/28/15)
Stock Update (NYSE:IBM): Facebook Partners with IBM to Provide Relevant Ads to Its Users (Jutia Group, 5/7/15)
Infinera Lights Some Facebook Fiber (Telecom Ramblings, 3/31/15)


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This is a breakdown of some of the VFX made for the Metamorphosis (2014)
It is a combination of live footage and CG elements completed using Houdini and Nuke. In this project I supervised three of our team members in production of the CG crystals. This video demonstrates tests, tools and techniques I developed.
Made with:
Vikram Chadha
Deniz Cinar
Arnau Lopéz
Nina Cohagen
Silja Hendriksdottir
Ona Eslape
Emma Cooper
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text:
Say I do I do I do I do I do
So we can float up outta here in this hot air balloon
Lets put a baby butterfly up in your lil' cocoon
And maybe 2030 our baby, she'll be nerdy make the whole club swoon
from Jeezy (Ft. Andre 3000 & Jay Z) – I Do Lyrics on Genius
They will get married and start their journey together. They'll make a baby girl that'll grow up to have his nerdiness and her goods. (First class brains and ass FTW!)
Also a clever continuation of wordplay. A hot air ballon is Benjamin Bixby's clothing logo.
To help improve the quality of the lyrics, visit Jeezy (Ft. Andre 3000 & Jay Z) – I Do Lyrics and leave a suggestion at the bottom of the page


text:
When you just don't know how to express your inner feelings, let one of these sassy tees say it for you.
3 Outfits That Will Land You An Internship In Fashion
"This year, it's all about taking risks, going on adventures, trying new styles, and turnin' it up—pump up the volume!"—Sam
"I actually took the liner out of this jacket to make it look like an oversized denim jacket, which I love. Oversized patchworked men's jackets are my staples and favorite."—Cailli
Steal The 8 Best Grammy Dresses For Prom!


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Discover what's up in the business of marketing each Friday.
Google's Home Page Clears United States Patent Office
Gawker reports Google's home page patent application, which was filed back in March 2004, has finally been approved yesterday, September 1, 2009. The patent is for the simplicity of the Google home page.
Here is a picture of the patented home page:
Postscript From Danny Sullivan: It's unclear yet whether Google intends to enforce its patent against other search engines that might feature a "clean" home page, such as Bing. If they tried, I think the patent would get defeated. Plenty of search engines prior to Google's 1998 launch had clean pages. I'm kind of amazed they got a patent here. If we have more, we'll update.
Be a part of the world's largest search marketing conference, Search Engine Land's SMX East. The robust agenda covers the latest tactics in paid search, SEO, mobile, analytics and more. Register today and save $300, or come as a team and save 10%-20%.


text:
|User Rating
|(50 Votes)
awesome movie...loved it
my heart went out for kundan...his innocence, adorable nature and above all love for zoya
Dhanush, Sonam, Abhay rocked it !!!!!
Excellent movie-Dhanush and Sonam clearly rocked
Dhanush indeed made my heart bleed.. he just breathed life in his role.. sonam was good too.. but for me it was a dhanush show.. no doubts in it.
The whole movie undoubtedly belonged to dhanush! First time watching his movie,, great actor
aww m so happy for my sona angel...finally shez getting the success she deserve...Raanjhanaa is worth watching movie and dhanush, sonam kapoor, abhay deol, rocks!!
I actually cried for five minutes after the movie was over! Dhanush you've made a new fan!
it is a must watch movie...great love story...u cant afford to miss this one..
I'm so thrilled by the success of this movie...espy for Dhanush and Sonam!
Its really an Awesome Movie, touching movie !!!!!!!!!!!!!!! A must watch, I must say!! Really loved a movie after so long!!!!
Wohooo!!!! Dhanush at his best
The actress recorded the song in 20 minutes flat thereby surprising ...
Actors Abhishek Bachchan, Rishi Kapoor, Asin and Supriya Pathak along ...


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Original recipe yields 4 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Ready In
We like venison steaks as well as beef and they have less fat. I'm glad to see that not everyone thinks venison must be soaked or marinated. The only thing I do different is add more spices, s...
I don't really consider this a recipe because its just frying up some meat with basic S&P and butter BUT it is good! However, to keep the meat tender, you need to add a couple TBLS of water. I...
I give it five stars only because it doesn't require the steaks to be grilled and I love fried venison. I honestly cook all steaks and chops this way most of the time. It's faster and easier. ...


text:
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so in the AngularJS docs I saw this about the injector:
// You write functions such as this one.
function doSomething(serviceA, serviceB) {
// do something here.
// Angular provides the injector for your application
var $injector = ...;
// the old-school way of getting dependencies.
var serviceA = $injector.get('serviceA');
var serviceB = $injector.get('serviceB');
// now call the function
doSomething(serviceA, serviceB);
// the cool way of getting dependencies.
// the $injector will supply the arguments to the function automatically
$injector.invoke(doSomething); // This is how the framework calls your functions
it looks nice. but i don't get it. in the last line where the injector looks for dependencies, isn't it exactly like having global variables serviceA, serviceB? I mean, say I would rewrite it like this:
var serviceA, serviceB;
function doSomething() {
// access serviceA, serviceB
what is the benefit of having the injector do that? I mean, if he can magically find the right objects for the arguments, doesn't it mean I can find them just as easily if they are global variables?
I hope my question is clear...


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Other identifiers for this part: SPY #: ALT-YD-TTU07-LED-SM, .
- Each product conforms to US Motor Vehicle Safety Standards
- All products are brand new, NOT used or refurbished
- Packaging is secure to prevent shipping damage
- As good as or better than the original OEM part
- DOT/SAE Certified
This part will fit the following vehicles:
|2007 - 2008
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Thanks to a winter frost heave and a tiny canvas carport I had the misfortune of accidentally breaking my side mirror when the car rolled over a bump in the driveway due to the tire positioning and the closer than close proximity of the poles holding up the carport wall. My neighbor who owns a garage tried to help me find a new mirror "preloved" so that I could save a few bucks. Even if he went to the junk yard himself and pulled it I was going to be paying at least $80. This was money that I didn't have for a side mirror I needed to have. He gave me his contact list & the website he uses to try and find the part on my own because I was getting ready for a road trip through a few states and we thought I would have better luck elsewhere. So online I went. Lots of phone calls made & websites searched but it wasn't until I came upon your website that I found what I was looking for at a price I could afford. I couldn't believe it. With shipping I was saving over $40 and the part which arrived 2 days after I got home from my trip looked perfect and still works great! I shared your website with my neighbor and he too was shocked by the price. We both love your website and while I haven't damaged anything since or needed any additional parts I will always visit your site 1st because I am confident that based on my experience with your customer service team and the pricing as well as shipping time and fantastic communication that I will always find the best deal when ordering from you.
Price Quality Average: 4.5 / 5 starsMy drivers side headlight was damaged in a hit and run accident with a deer. The deer hit me and ran away (no joke) The Go-Part replacement cost was 1/4 of the cost from the dealership which would have also charged me to install it. Thank you Go-Parts.by aliciaj
Price Quality Average: 5 / 5 starsYou should indicate when a product will ship and be delivered before requiring the completion of the purchase.by COD
Price Quality Average: 4.5 / 5 starsOrder was shipped in a timely manner. Part fit great.by olde77
Price Quality Average: 4.5 / 5 starsIt is professionally done on time, I got my parts as promisedby ttecle


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Bacalao Portuguese
11 Jul 2009
|Salted cod
|1 Pound
|Cold water
|2 Cup (32 tbs)
|Olive oil
|3 Tablespoon
|Frozen shoestring potatoes
|2 Cup (32 tbs)
|1 Large, chopped
|6 , beaten
|1⁄2 Cup (8 tbs)
|Tabasco sauce
|3⁄4 Teaspoon
|Chopped parsley
|2 Tablespoon
|Black olives
|1⁄2 Cup (8 tbs)
|Fresh parsley sprigs
Soak cod overnight in cold water, changing water 3 or 4 times before bedtime; drain and rinse in running water.
Cover fish with water in a large saucepan; bring to a boil. (Taste water; if too salty, replace with fresh.)
Simmer fish, uncovered, 20 minutes, or until fish flakes when tested with a fork; drain, flake fish and set aside.
Heat oil in a large skillet; saute potatoes until golden, about 7 minutes.
Stir in onion; cook until soft.
Add fish; mix well.
Beat eggs in a small bowl; add milk, Tabasco sauce and parsley, mixing well.
Pour egg mixture over fish and potatoes; stir until eggs form soft curds.
Cover and cook over low heat until eggs are set.
Garnish with black olives and fresh parsley sprigs.
Recipe Summary
Course:Side Dish
Rate It
0 Comments
Bacalao Portuguese Recipe


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• Our warming blend of Hinoki, Juniper, Orange, Ginger, and Patchouli essential oils entice the senses
• Epsom Salts are known to help with sore muscles and detoxification
• Himalayan Pink Salt is an exotic fossilized marine salt formed more than 250 million years ago. Its rare and exotic pink hue and high mineral content have made pink salt one of the most sought after bathing salts in the world
• California Sun Dried Sea Salts are high in trace minerals
• Vitamin E supports healthy skin
Sodium Chloride (California Sea Salt, Himalayan Pink Salt), Magnesium Sulfate (Epsom Salt), EO Essential Oil Blend [Chamecyparis Obutus (Hinoki) Oil, Juniperus Communis Fruit Oil, Citrus Nobilis (Mandarin Orange) Peel Oil, Zingiber Officinale (Ginger) Root Oil, Juniperus Virginiana Oil, Pogostemon Cablin) Oil], Tocopherol
Pour generously into warm, running water. As the salts blend with your bath, inhale the warm scent of ginger and hinoki. Slip into this stimulating bath and let the warmth infuse you. Indulge in warm thoughts.
EO is Essential Oils. For over twenty beautiful years the aromatic essences of flowers, trees, resins, spices and plants have been the heart and soul of everything we do. We believe in real scents made from real plantss and we think clean, healthy skin is beautiful.


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Note: It's come to my attention that some of the schadenfreude-afflicted, both here on LiveJournal and elsewhere, are angry at the idea that schadenfreude could be considered to be a mental defect of its own, and that their attitude about "fun" could be characterized in such a fashion.
All I can say is that if an individual finds it "fun" to verbally pummel another human being until tears come forth, and/or to the point of causing suicides (as happened in Vermont in 2003, Missouri in 2006, Florida in both 2008 and 2009, and Massachusetts in 2010, and several more each year in other states since), then there is in fact something wrong with that individual's personality and corrective action is needed, whether it be psychiatric, judicial, or a combination of the two.
|Depression is NOT shameful
| You scored as Ravenclaw. You have been sorted into Ravenclaw -- you value intelligence, and love the chance to use your cleverness (and maybe even show it off...just a little). You're keen and incisive, and you just love a challenging problem to solve.
The Hogwarts Sorting Hat!
created with QuizFarm.com
|Ravenclaws are intellectual.
|Everyone Feels This Pain
|Show your support
Greece is the Birthplace of Democracy
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