text:
Cardiff owner Vincent Tan makes more news by offering an illegal bonus to his players
Mar 3, 2014, 9:50 PM EDT
Cardiff City owner Vincent Tan, like most owners, really would like to stay up in the Premier League and reap the fiscal and spiritual rewards of playing in England's top flight.
As such, he reportedly offered his players a bonus of nearly $6.2 million if they're able to stave off relegation. Such bonuses are nothing new, so what's the problem?
Well, Tan made the offer before this weekend's match between his Bluebirds and Tottenham Hotspur, meaning it's come long after the due date for such bonuses (which have to come before the start of the Premier League season).
A spokesman for Tan told the Daily Mail that they didn't realize they were breaking any rules by extending the bonus offer, and that they would be rescinding it.
If you're looking for a bit of a laugh out of this relatively dry ordeal, Tan apparently told the players they "needed to shoot more" while notifying the players of his offer.
- digbysellers - Mar 3, 2014 at 9:58 PM
This guy is a real clown show
- judgereed - Mar 3, 2014 at 10:11 PM
How was this lunatic able to buy a team?? Like do they screen owners like sports in the US do????
- Matthew - Mar 3, 2014 at 10:31 PM
Reblogged this on Carolina Mountain Blue and commented:
…and people still think Vincent Tan's a good owner? He's starting to make both Jeffrey Loria and Donald Sterling look like fricken geniuses…and that's sad.
- mdac1012 - Mar 4, 2014 at 8:07 AM
If the next James Bond movie doesn't have an Asian football club owner as it's villain I will be very disappointed.
- frankdlaw - Mar 4, 2014 at 11:24 AM
This story has really plumbed the depths of yellow journalism and struck a raw nerve! Vincent Tan is probably right. The British press IS RACIST!
As a United supporter, I thought the "green and gold" campaign was bad, but this latest diatribe against Vincent Tan violates every principle of fair play and is clearly a shiver looking for a spine to run up! For an owner on an obvious learning curve to receive this amount of flack smacks of an inquisition! You mean he has to be up to speed instantly and be totally conversant with the rules of football plus all the obscure and archaic rules of the Premier League even when trying to motivate his players?
The British press reflects a reflexive hostility to the man when an innocent mistake made out of genuine ignorance results in him being pilloried on the stake of racial prejudice?
It was Duncan Spaeth who said:"I know why the sun never sets on the British Empire. God wouldn't trust a Britisher in the dark!" Now how does that feel, you racists? What's happened to Britain? You've prided yourself as a land where freedom reigns. Now it looks like prejudice and racial bias is the best that Britain can muster. It can be put down to "stuff happens" and people change. There's a more scatological way to put it, but you get my drift?
- thesublimeylimey - Mar 4, 2014 at 11:39 AM
I surprised you managed to write all that with your knee jerking so much.
- frankdlaw - Jul 17, 2014 at 12:14 AM
I'm surprised you're able to write all that with your brain short-circuiting so much!
Top Posts
- 2015 Gold Cup predictions: Can the USMNT win back-to-back titles? Here's our picks… 1
- Where does Andrea Pirlo joining New York City FC rank in history of MLS mega-deals? 2
- 2015 Gold Cup: USMNT player profiles – Midfielders 0
- Reflecting on Michael Bradley from 1-99, as he hits 100 USMNT caps vs. Honduras 0
- Gold Cup Today: USMNT face Honduras, Panama vs. Haiti kick things off – Day 1 2
- Transfer Rumor Roundup: Darmian to Manchester United, Clasie to Southampton 0


text:
Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1β converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##
1. A pharmaceutical composition for inhibiting ICE comprising a pharmaceutically acceptable carrier and a non-toxic therapeutically effective amount of compound of formula I which is gamma-pyrone-3-acetic acid ##STR3## or a pharmaceutically acceptable salt thereof wherein said effective amount is 5 mg to 500 mg of formula I.
2. A method of treating inflammation in a patient in need of such treatment comprising: administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of gamma-pyrone-3-acetic acid.
3. A method according to claim 2 wherein said inflammation is due to septic shock.
4. A method according to claim 2 wherein said inflammation is due to arthritis.
This invention relates to gamma-pyrone-3-acetic acid and a process of making this compound. Applicants have found that gamma-pyrone-3-acetic acid is useful in the treatment of inflammation in lung, central nervous system, kidney, joints, endocardium, pericardium, eyes, ears, skin, gastrointestinal tract and urogenital system. Interleukin-1β converting enzyme (ICE) has been identified as the enzyme responsible for converting precursor interleukin-1β (IL- 1β) to biologically active IL-1β.
Mammalian interleukin-1 (IL-1) is an immunoregulatory protein secreted by cell types as part of the inflammatory response. The primary cell type responsible for IL-1 production is the peripheral blood monocyte. Other cell types have also been described as releasing or containing IL-1 or IL-1 like molecules. These include epithelial cells (Luger, et al., J. Immunol. 127:1493-1498 (1981), Le et al., J. Immunol. 138:2520-2526 (1987) and Lovett and Larsen, J. Clin. Invest. 82:115-122 (1988), connective tissue cells (Ollivierre et al., Biochem. Biophys. Res. Comm. 14 1: 904-911 (1986), Le et al, J. Immunol. 138:2520-2526 (1987), cells of neuronal origin (Giulian et al., J. Esp. Med. 164:594-604 (1986) and leukocytes (Pistoia et al., J. Immunol. 136:1688-1692 (1986), Acres et al., Mol. Immuno. 24:479-485 (1987), Acres et al., J. Immunol. 138: 2132-2136 (1987) and Lindenmann et al., J. Immunol 140:837-839 (1988).
Biologically active IL-1 exists in two distinct forms, IL-1α with an isoelectric point of about pI 5.2 and IL-113 with an isoelectric point of about 7.0 with both forms having a molecular mass of about 17,500 (Bayne et al., J. Esp. Med. 163:1267-1280 (1986) and Schmidt, J. Esp. Med. 160:772 (1984). The polypeptides appear evolutionarily conserved, showing about 27-33% homology at the amino acid level (Clark et al., Nucleic Acids Res. 14:7897-7914 (1986).
Mammalian IL-1β is synthesized as a cell associated precursor polypeptide with a molecular mass of about 31.4 kDa (Limjuco et al., Proc. Natl. Acad. Sci USA 83:3972-3976 (1986). Precursor IL-1β is unable to bind to IL-1 receptors and is biologically inactive (Mosley et al., J. Biol. Chem. 262:2941-2944 (1987). Biological activity appears dependent upon some form of proteolytic processing which results in the conversion of the precursor 31.5 kDa form to the mature 17.5 kDa form. Evidence is growing that by inhibiting the conversion of precursor IL-1β to mature IL-1β, one can effectively inhibit the activity of interleukin-1.
Mammalian cells capable of producing IL-1β include, but are not limited to, karatinocytes, endothelial cells, mesangial cells, thymic epithelial cells, derreal fibroblasts, chondrocytes, astrocytes, glioma cells, mononuclear phagocytes, granulocytes, T and B lymphocytes and NK cells.
As discussed by J. J. Oppenheim, et al. Immunology Today, vol. 7(2):45-56 (1986), the activities of interleukin-1 are many. It has been observed that Catabolin, a factor that promotes degradation of cartilage matrix, also exhibited the thymocyte comitogenic activities of IL-1 and stimulates chondrocytes to release collagenase neutral proteases and plasminogen activator. In addition, a plasma factor termed proteolysis inducing factor stimulates muscle cells to produce prostaglandins which in turn leads to proteolysis, the release of amino acids and, in the long run, muscle wasting, and appears to represent a fragment of IL-1 with fever-inducing, acute phase response and thymocyte co-mitogenic activities.
IL-1 has multiple effects on cells involved in inflammation and wound healing. Subcutaneous injection of IL-1 leads to margination of neutrophils and maximal extravascular infiltration of the polymorphonuclear leukocytes (PMN). In vitro studies reveal IL-1 to be a chemotactic attractant for PMN to activate PMN to metabolize glucose more rapidly to reduce nitroblue tetrazolium and to release their lysozomal enzymes. Endothelial cells are stimulated to proliferate by IL-1 to produce thromboxane, to become more adhesive and to release procoagulant activity. IL-1 also enhances collagen type IV production by epidermal cells, induces osteoblast proliferation and alkaline phosphatase production and stimulates osteoclasts to resorb bone. Even macrophages have been reported to be chemotactically attracted to IL-1 to produce prostaglandins in response to IL-1 and to exhibit a more prolonged and active tumoricidal state.
IL-1 is also a potent bone resorptive agent capable upon infusion into mice of causing hypercaleemia and increase in bone resorptive surface as revealed by his to morphometry Sabatini, M. et al., PNAS 85: 5235-5239, 1988.
Accordingly, disease states in which the ICE inhibitors of Formula I may be useful as therapeutic agents include, but are not limited to, infectious diseases where active infection exists at any body site, such as meningitis and salpingitis; complications of infections including septic shock, disseminated intravascular coagulation, and/or adult respiratory distress syndrome; acute or chronic inflammation due to antigen, antibody, and/or complement deposition; inflammatory conditions including arthritis, cholangitis, colitis, encephalitis, endocarditis, glomerulonephritis, hepatitis, myocarditis, pancreatitis, pericarditis, reperfusion injury and vasculitis. Immune-based diseases which may be responsive to ICE inhibitors of Formula I include but are not limited to conditions involving T-cells and/or macrophages such as acute and delayed hypersensitivity, graft rejection, and graft-versus-host-disease; auto-immune diseases including Type I diabetes mellitus and multiple sclerosis. ICE inhibitors of Formula I may also be useful in the treatment of bone and cartilage resorption as well as diseases resulting in excessive deposition of extracellular matrix. Such diseases include peridonate diseases interstitial pulmonary fibrosis, cirrhosis, systemic sclerosis, and keloid formation. ICE inhibitors of Formula I may also be useful in treatment of certain tumors which produce IL 1 as an autocrine growth factor and in preventing the cachexia associated with certain tumors.
The invention is directed to gamma-pyrone-3-acetic acid, which has been found to be potent inhibitor of interleukin-1β converting enzyme (ICE). The invention is also directed to a process for making gamma-pyrone-3-acetic acid by the fermentation of the fungus MF5809, Xylaria sp.ATCC accession No. 74223, by submerged aerobic culture of a suitable aqueous medium, containing assimilable sources of carbon, nitrogen and inorganic salts.
In one embodiment the invention encompasses compound I, gamma-pyrone-3-acetic acid ##STR2## which has been found to be potent inhibitor of interleukin-1β converting enzyme (ICE).
In a second embodiment the invention is directed to pharmaceutical compositions for inhibiting ICE and for treating ICE mediated diseases as disclosed herein comprising a non-toxic therapeutically effective amount of gamma-pyrone-3-acetic acid and a pharmaceutically acceptable carrier.
In a third embodiment the invention is directed to methods of inhibiting ICE and methods of treating ICE mediated diseases comprising: administration to a patient in need of such inhibition or treatment of a non-toxic therapeutically effective amount of gamma-pyrone-3-acetic acid.
Illustrative of these aspects, this invention concerns pharmaceutical compositions and methods of treatment of diseases selected from septic shock, allograft rejection, inflammatory bowel disease and rheumatoid arthritis in a patient in need of such treatment.
In a fourth embodiment the invention is directed to a process for making gamma-pyrone-3-acetic acid by the fermentation of the fungus MF5809, Xylaria sp. (AscomyCotina, Xylariales), ATCC accession No. 74223, by submerged aerobic culture of a suitable aqueous medium, containing assimilable sources of carbon, nitrogen and inorganic salts.
Within this embodiment the invention concerns a process for the preparation of gamma-pyrone-3-acetic acid which comprises:
(a) culturing a microorganism MF5809, Xylaria sp., ATCC accession No. 74223, or a mutant thereof, in a nutrient medium containing assimilable sources of nitrogen and carbon under aerobic conditions until a substantial amount of the compound is produced, and
(b) isolating the compound so produced.
In a fifth embodiment the invention is directed to the present invention involves a biologically pure culture of MF5809, Xylaria sp., ATCC accession No. 74223, or a mutant thereof, capable of producing compound gamma-pyrone-3-acetic acid.
The culture was deposited under the Budapest Treaty with the American Type Culture Collection, Rockville, Md., on Apr. 15, 1993 under ATCC accession No. 74223 and is currently maintained as a biologically pure culture in the Merck Culture Collection as MF5809.
As indicated above, the present invention is not limited to a single strain of microorganism. Included within the scope of this invention is the use of other natural or artificial mutants or variants derived from the described culture. The artificial production of mutant strains of MF5809, Xylaria sp., ATCC accession No. 74223, may be achieved by physical or chemical mutagens, for example, ultraviolet irradiation or N-nitrosoguanidine treatment and the like. Recombinant. DNA techniques such as protoplast fusion, plasmid incorporation, gene transfer and the like are also envisioned.
The producing organism, MF5809, was isolated from living bark of a live oak (Quercus sp.) in Columbia, S.C. and was grown in medium CYG40 for 21 days at 25� C. The isolation and description of the species is as follows:
Isolation--Bark discs were obtained by use of a leather punch (3/8") and a hammer. The punch was hammered through the bark until it enters the xylem. The punched material was surface sterilized by dipping the material in ethanol for 1 minute; sodium hypochlorite for 3-5 minutes and finally ethanol for an additional half minute. The sodium hypochlorite dip is made from Chlorox� or similar product diluted 1:3. The punched bark disc was placed in 100 mm petri dishes and incubated on agar media at 20�-25� C. until growth was observed. Mycelium of the above mentioned organism emerged from internal bark tissue. Mycelium was transferred to slants of potato dextrose agar (DIFCO) to initiate an axenic culture. In culture, MF 5809 exhibits the following morphological features.
Xylaria sp. (MF 5809)
Colony on oatmeal agar (Difco) covering a 9 cm Petri dish after 15 d at 25� C. and 50% relative humidity in 12 hr photo period; growing edge appressed, margin indistinct, scalloped, roycellium at first white, velvety, followed by a distinct zone of velvety, olive-black, carbonaceous mycelium which is the color and texture at maturity, is aerial mycelium at colony center (inoculation point) white, cottony, sparse. Stromata few, restricted to colony center, robust, base villose, "mole" type, 1.0-1.5�0.4-0.6 cm, olive-black, apical portion white to tan, dissected. Teleomorph and anamorph absent. Carbonaceous hyphae thick-walled, bristle-like appearance, olivaceous, 6.0-7.0 gm wide. Hyphae from white, underlying mycelium, hyaline, thin-walled, smooth, 4.0-5.0 gm. Reverse uncolored. Exudate clear droplets on colony surface and stromata.
Because of the characteristic stromata and colony morphology, this endophytic fungus is easily placed in the genus Xylaria. The isolate produces no teleomorph (sexual state) or anamorph (asexual state) in culture. The characteristics present in MF 5809 do not fit into any of the species described in Callan, B. E. and J. D. Rogers. 1992. A synoptic key to Xylaria species from continental United States and Canada based on cultural and anamorphic features. Mycotaxon. 46: 141-154). Some individual key characters of this isolate, such as growth rate or stroma morphology, may be similar to those of different Xylaria species, but the panoply of characters do not fit any of the reported species.
Compound I may be obtained by cultivating MF5809, Xylaria sp., ATCC accession No. 74223 in a suitable nutrient medium under conditions hereinafter described until a substantial amount of the product is formed in the culture medium, harvesting by filtration and chromatographic separation of the active component from the fermentation medium, then concentrating the solution containing the active components, and subjecting the concentrated solution to a second chromatographic separation procedure to isolate Compound I.
Suitable nutrient medium contain sources of carbon and nitrogen assimilable by the microorganism and also containing low levels of inorganic salts. The medium may be supplemented with trace metals, although if complex sources of carbon and nitrogen are employed, trace metals are usually present in the complex sources.
Suitable sources of carbon include glycerol, sugars, sugar alcohols, starches and other carbohydrates, or carbohydrate derivatives such as dextran, cerelose, as well as complex nutrients such as oat flour, corn meal, millet, corn and the like. The exact quantity of the carbon source which is utilized in the medium will depend, in part, upon the other ingredients in the medium, but it is usually found that an amount of carbohydrate between 0.5 and 40 percent by weight of the medium is satisfactory. These carbon sources can be used individually or several such carbon sources may be combined in the same medium.
The sources of nitrogen include amino acids such as glycine, arginine, threonine, methionine and the like, ammonium salt, as well as complex sources such as yeast hydrolysates, yeast autolysates, yeast cells, tomato paste, soybean meal, casein hydrolysates, yeast extracts, corn steep liquors, distillers solubles, cottonseed meal, meat extract, and the like. The various sources of nitrogen can be used alone or in combination in amounts ranging from 0.2 to 10 percent by weight of the medium.
Among the nutrient inorganic salts, which can be incorporated in the culture media are the customary salts capable of yielding sodium, potassium, magnesium, calcium, phosphate, sulfate, chloride, carbonate, and like ions. Also included are trace metals such as cobalt, manganese, iron, molybdenum, zinc, cadmium, and the like.
The cultivation generally is carded out first by growing the culture in a seed medium such as KF seed medium 3 days and then employing a portion of the cultivated seed medium to inoculate the production medium such as CYG40 production medium. The production cultures are then grown for up to 21 days, preferably 7 to 21 days.
The seed production media most frequently employed in cultivation are as follows:
TABLE 1______________________________________Composition of KF Seed Medium per liter of distilled H2 O______________________________________Corn Steep Liquor 5 gTomato Paste 40 gOat flour 10 gGlucose 10 gTrace Element Mix* 10 mlpH = 6.8FeSO4.7H2 O 1 gMnSO4.4H2 O 1 gCuCl2.2H2 O 25 mgCaCl2 100 mgH3 BO3 56 mg(NH4)6 Mo7 O24.4H2 O 19 mgZnSO4.7H2 O 200 mg______________________________________ *Trace Element Mix
TABLE 2______________________________________Composition of CYG40 Production Medium per liter of distilled H2 O______________________________________Cornmeal (yellow) 50 gYeast Extract 1 gDextrose 40 gNo pH adjustment______________________________________
After completion of the fermentation period, in the preferred procedure, whole broth at near neutral pH (6.5) was filtered and passed through an anion exchange resin such DOWEX 1. Active compound was eluted with a suitable salt such as 2.5% NaCl, and the ICE-active NaCl fractions from the resin were pooled and passed through a reverse-phase resin such as SP 207 and eluted with water. The ICE-active fractions were lyophilized, reconstituted and filtered through a microporous filter.
Compound can be isolated further by purification using HPLC such as by passage through a C4 radial compression column. An isocratic flow rate of 10 mL per minute of water is preferred for eluting the active compound. Compounds of the instant invention are conveniently prepared using the procedures described generally below and more explicitly described in the Example section thereafter.
This invention also relates to a method of treatment for patients (including man and/or mammalian animals raised in the dairy, meat, or fur industries or as pets) suffering from disorders or diseases which can be attributed to ICE as previously described, and more specifically, a method of treatment involving the administration of the ICE inhibitor of formula (I) as the active constituents.
Accordingly, disease states in which the ICE inhibitor of Formula I may be useful as therapeutic agents include, but are not limited to, infectious diseases where active infection exists at any body site, such as meningitis and salpingitis; complications of infections including septic shock, disseminated intravascular coagulation, and/or adult respiratory distress syndrome; acute or chronic inflammation due to antigen, antibody, and/or complement deposition; inflammatory conditions including arthritis, cholangitis, colitis, encephalitis, endocarditis, glomerulonephritis, hepatitis, myocarditis, pancreatitis, pericarditis, reperfusion injury and vasculitis. Immune-based diseases which may be responsive to ICE inhibitors of Formula I include but are not limited to conditions involving T-cells and/or macrophages such as acute and delayed hypersensitivity, graft rejection, and graft-versus-host-disease; auto-immune diseases including Type I diabetes mellitus and multiple sclerosis. ICE inhibitors of Formula I may also be useful in the treatment of bone and cartilage resorption as well as diseases resulting in excessive deposition of extracellular matrix such as interstitial pulmonary fibrosis, cirrhosis, systemic sclerosis, and keloid formation. ICE inhibitors of Formula I may also be useful in treatment of certain tumors which produce IL 1 as an autocrine growth factor and in preventing the cachexia associated with certain tumors.
For the treatment the above mentioned diseases, the compounds of formula (I) may be administered orally, topically, parenterally, by inhalation spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intracistemal injection or infusion techniques. In addition to the treatment of warm-blooded animals such as mice, rats, horses, cattle, sheep, dogs, cats, etc., the compounds of the invention are effective in the treatment of humans.
The pharmaceutical compositions containing the active ingredient may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, or syrups or elixirs. Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavoring agents, coloring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets contain the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets. These excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example, cornstarch, or alginic acid; binding agents, for example starch, gelatin or acacia, and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate may be employed. They may also be coated by the techniques described in the U.S. Pat. Nos. 4,256,108; 4,166,452; and 4,265,874 to form osmotic therapeutic tablets for control release.
Formulations for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin, or olive oil.
Aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethyl-cellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally-occurring phosphatide, for example lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyl-eneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides; for example polyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more preservatives, for example ethyl, or n-propyl, p-hydroxybenzoate, one or more coloring agents, one or more flavoring agents, and one or more sweetening agents, such as sucrose or saccharin.
Oily suspensions may be formulated by suspending the active ingredient in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavoring agents may be added to provide a palatable oral preparation. These compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid.
Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example sweetening, flavoring and coloring agents, may also be present.
The pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions. The oily phase may be a vegetable oil, for example olive oil or arachis oil, or a mineral oil, for example liquid paraffin or mixtures of these. Suitable emulsifying agents may be naturally-occurring gums, for example gum acacia or gum tragacanth, naturally-occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol anhydrides, for example sorbitan monooleate, and condensation products of the said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monooleate. The emulsions may also contain sweetening and flavoring agents.
Syrups and elixirs may be formulated with sweetening agents, for example glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavoring and coloring agents. The pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleagenous suspension. This suspension may be formulated according to the known an using those suitable dispersing or wetting agents and suspending agents which have been mentioned above. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, for example as a solution in 1,3-butane diol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables.
The compounds of formula (I) may also be administered in the form of suppositories for rectal administration of the drug. These compositions can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug. Such materials are cocoa butter and polyethylene glycols.
For topical use, creams, ointments, jellies, solutions or suspensions, etc., containing the compounds of Formula (I) are employed. (For purposes of this application, topical application shall include mouth washes and gargles.)
Dosage levels of the order of from about 0.05 mg to about 140 mg per kilogram of body weight per day are useful in the treatment of the s above-indicated conditions (about 2.5 mg to about 7 gms. per patient per day). For example, inflammation may be effectively treated by the administration of from about 0.01 to 50 mg of the compound per kilogram of body weight per day (about 0.5 mg to about 3.5 gms per patient per day).
The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. For example, a formulation intended for the oral administration of humans may contain from 0.5 mg to 5 gm of active agent compounded with an appropriate and convenient amount of carrier material which may vary from about 5 to about 95 percent of the total composition. Dosage unit forms will generally contain between from about 1 mg to about 500 mg of an active ingredient.
It will be understood, however, that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, rate of excretion, drug combination and the severity of the particular disease undergoing therapy.
The following Examples are intended to illustrate the preparation of compounds of Formula I, and as such are not intended to limit the invention as set forth in the claims appended, thereto.
Production of the ICE- active gamma-pyrone-3-acetic acid, by fermentation of fungus MF5809, Xylaria sp.
Organism MF5809 was isolated from a living bark of a live oak (Quercus sp.) in Columbia, S.C. and was initially grown in medium CYG40 (Table 2) for 21 days at 25 � C.
General Growth Conditions: MF5809 was grown in cotton-plugged, 250-ml Erlenmeyer flasks containing either 54 ml of the KF seed medium (Table 1 ) or 45 ml of CYG40 production medium (composition in Table 2). Cultures were incubated at 25� C. on a rotary shaker at 5-cm throw at 220 rpm for 3 days in seed medium or for up to 21 days in production medium.
Preparation of Standardized Frozen Inoculum: An initial source material of MF5809 was used to inoculate KF seed medium. The resulting 3-day culture was used to make frozen vegetative mycelia by mixing the broth with an equal volume of 20% glycerol and dispensing 2-ml portions of the mixture into sterile vials for storage at -80 � C. A second set of frozen vegetative mycelia was made by the same procedure from a KF culture that had been inoculated with mycelia from the first set of vials.
Preparation of the Seed Culture: A flask of KF seed medium was inoculated with a 2-ml portion of frozen vegetative mycelia and incubated for 3 days.
Production Protocol: A 2-ml aliquot of the seed culture was used to inoculate each 45-ml portion of CYG40 production medium. These production cultures were grown at for up to 21 days in 250 ml flasks. A study of the course of production showed that production of the active compound began by day 7 and that activity remained at day 21.
Harvest: After 10-21 days, the contents of the flasks were pooled for isolation of gamma-pyrone-3-acetic acid.
Whole broth at pH 6.5 (300 mL) was filtered through a glass Buchner funnel (fine porosity) yielding 250 mL. Filtered broth was passed through 50 mL DOWEX 1 (1�2) anion exchange resin. Active compound was eluted with one column volume of 2.5% NaCl. The ICE-active NaCl fractions from the DOWEX 1 resin were pooled and passed through 50 mL of the MITSUISHI reverse-phase resin SP 207 and eluted with water. The ICE-active fractions eluted between 0.5 and 2.0 column volumes. The ICE-active fractions were pooled and lyophilized for 24 hours. The lyophilized fractions were reconstituted with 10 mL of water and filtered through a 0.20μ filter.
Compound was isolated further by purification using HPLC. Two mL of filtered solution was passed through a C4 radial compression column (25�100 mm, WATERS ASSOCIATES) and an isocratic flow rate of 10 mL per minute of water was used to elute the active compound. A total of 5 runs were performed with fractions being collected at one minute intervals. The fractions were tested for ICE-activity. The active fractions eluted between 9-10 minutes. The ICE-active-rich cuts from each run were pooled and lyophilized. The resulting material appeared to be an oily brown substance that was soluble in water, methanol, and DMSO. Estimates of 7 mg of compound can be isolated from 300 ml of whole broth.
The molecular formula C7 H6 O4 was determined by high resolution EI-MS (calc. 154.0266; found 154.0268).
13 C NMR (D2 O, 125 MHz) 34.6, 116.4, 126.6, 157.0, 158.9, 179.1, 182.1 ppm referenced to internal dioxane at 67.4 ppm downfield of TMS.
1 H NMR (D2 O, 500 MHz) δ3.02 (d, j=1,2H), 6.28 (d, j=5.5, 1H), 7.86 (dt, j=1.0, 1.0, 1H), 7.89 (dd, j=1.0, 5.5, 1H), referenced to internal dioxane at δ3.53 downfield of TMS.
Gamma-pyrone-3-acetic acid was assessed for ICE activity by the procedure of Thomberry, et al (1992) Nature Vol. 356 pp 768-774. The compound was found to possess an IC50 of 0.2 μg/ml at pH 6.5 and 1 mM DDT; and an IC50 of 0.7 ∞g/ml at pH 7:5 and 1 mM DDT.
Patent Citations
Non-Patent Citations
Referenced by
Legal Events
Original Image

subset: commoncrawl


text:
Final Audio Design Heaven IV
"Final Audio Design is a relatively new company to the IEM scene, with them releasing their first models in 2009. They are a Japanese company, with their roots extending back to 1974 where they first made high-end MC cartridges and booster transformers. The model that I will be reviewing today is their Heaven IV, which is the second cheapest model in their Heaven IEM series, the most basic one..." --lin0003
Final Audio Design FI-BA-SS
"We wants it, we needs it. Must have the precious. They cursed us. Murderer they called us. They cursed us, and drove us away. And we wept, Precious, we wept to be so alone. And we only wish to catch fish so juicy sweet. And we forgot the taste of bread... the sound of trees... the softness of the wind. We even forgot our own name. My Precious. " --tomscy2000
Final Audio Design Adagio V
" Hi Guys, this is my second review on a new earphone, just in time that my friend is looking for a good earphone, I was recommend him to look for this Final Audio Design brand. He loves detail, clarity type of earphone, and mostly enjoys vocal, acoustic music type. And hey!! He picked a final audio adagio V!! I didn't expect this will happen, but well, i got his..." --SpringBiscuit
Final Audio Design Adagio III
"Final Audio Adagio III Quick Review Thanks to Hifiheadphones for the sample. Full review here http://www.head-fi.org/t/744122/final-audio-adagio-iii-review-by-mark2410 Brief: Oh god, oh dear god, so much bass!!!!! Price: £59. In the US they seem to vary wildly Specification: Earphone Type: Intraaural (in the ear), Driver Unit:..." --mark2410
Final Audio Design Heaven II
"Final Audio Design Heaven II – A Taste of Heaven Intro First of all, I would like to sincerely thank Yoko at Final Audio Design for sending me a review sample of the Heaven II for review. I would like to clarify that I am in no way affiliated with Final Audio Design or any of its staff, and that I am not being compensated or paid by writing this review. All..." --thatBeatsguy
Ironbuds from Acoustic Forge - under $50 ecobuds
" I am tired of: throwing away earphones, wasting money, and destroying the environment. Ironbuds promised to be an answer to all three - imho they've cracked it. What is surprising is how good they sound. Been waiting a year for Acoustic Forge to release these. I posted in the forums about 8 months ago about them - but Thomas (the CEO) announced they were having some difficulties..." --intelegant
Final Audio Design FAD-BA-SB
Specifications: Driver: Balanced Armature Sensitivity: 112dB Impedance: 16Ω Cable length: 1,4m Weight: 23g
Final Audio Design Heaven Viii
"Details: Single balanced armature flagship universal IEMs from Final Audio Design Price: Heaven VII EU 550; Heaven VIII EU 600 Specs: Driver: Single BA | Imp: 24Ω | Sens: 106 dB | Freq: not stated | Cable: 1.2m straight plug Preferred tips: As supplied Wear Style: Straight down Disclosure: I purchased the Heaven VIIIs with my own..." --newzild
Final Audio Design Adagio II
"Final Audio Design Adagio II – Sonic Boom Intro Before I begin, I would like to sincerely thank Yoko at Final Audio Design for providing a sample of the Adagio II for review. I would like to clarify that I am neither affiliated with Final Audio Design or any of its staff, nor am I being paid or compensated in any form by writing this review..." --thatBeatsguy
Heaven VII
Heaven VII pursues the special attributes of final audio design products – a vast sound stage and vivid vocals. The vocals reverberate warmly across the full-range of clear sounds achieved with the product. With MIM (Metal Injection Molding), a special metal working process, a housing that optimizes acoustics not possible through regular machining is achieved. Compared to before, a new...


text:
Friday, October 14, 2011
Rick DiPietro Is Probably Made Of Glass
This being the latest injury in the oft-injured DiPietro's career. A career which is highlighted by a contact signed in 2006 that locked DiPietro up for 15 years with a $4.5 million annual cap hit. However, injuries have recently kept DiPietro from being the Islanders' go to goalie.
Last season, after DiPietro suffered facial fractures (pictured above) courtesy of a one punch knockout by Brent Johnson, of the Pittsburgh Penguins, Scott Lewis at the Score was generous enough to put together this snapshot of DiPietro's history of injuries.
Hip surgery: nine games
Knee surgery: 60 games
Swollen right knee: 41 games
Various knee injuries: 36 games
Lower body injury: one game
Groin: 13 games
Neck injury: two games
Concussion: one game
Personal reasons: three games
Flu: two games
Headache: eight games
Those injuries have limited DiPietro to just 39 games played since the beginning of the '08-'09 season.
Now DiPietro will have to go through the necessary steps that goes along with recovery from a concussion. Hopefully he doesn't stub his toe while hes is recovering because who knows when we'll see him back on the ice if that happens.
3 comments:
- AnonymousMay 6, 2012 at 10:02 AM
This sounds like an insurance scam/laundering repayment between the DiPietro family and the Islanders. The Islander owner repays the money he owes to the DiPietro family through Rick's contract and they recoup their costs by letting the insurance company pay ricks contract due to "injuries". They never intended this stiff to play goalie for them. This is a masterpiece that should be studied in business school. Or in a court of law. haReplyDelete
- AnonymousMay 6, 2012 at 10:04 AM
That black eye was given to him by his own family members when he demanded to play net because he's tired of being "injured".ReplyDelete
The produces the trendy Appearance any quite significantly less tag heuer replica, even more fashion-friendly possibility meant for giving wearable mechanic towards your clothes. There are several different kinds of touchscreen timepieces these days, thru choices the fact that appearance hardly any distinct from an individual's standard wind-up see in an effort to personal pc timepieces the fact that rado replica undertake just about everything your own private cell phone is capable of. Any World See Provider (IWC) is without question among the many top-ranking Swiss providers for high-end timepieces. rado replica gives the great set the fact that caters to most of flavor together with replicate hassle-free layout together with love. Rolex, any type the fact that alongside one another blends greatest elegance & richness, mirrors a good great culture for rolex replica earning. Lovely variations together with flawless workmanship are definitely the several good behavior for Rolex swiss watches. Those pieces happen to be when the alloys encounter wonderfully; hardly any consider, so why Rolex stands out as the most desired type worldwide. During the story of fabricating dust-proof timepieces, Rolex was initially the main to undertake any breitling replica. At this time, any identity usually means a good popularity icon.ReplyDelete


text:
The pending list of free agents for the Washington Capitals includes several big names, but while there is little question that players like Braden Holtby and Evgeny Kuznetsov will be re-signed, the future remains much more cloudy for defenseman Mike Green.
Green was selected 29th overall by the Caps in the 2004 draft and has spent his entire NHL career with the organization. He will turn 30 in October so while his 30-plus goal seasons are likely behind him, he still has plenty of good years left in his career.
Yet, the final year of Green's contract has now come and gone with no extension in place. While there remains time between now and the start of free agency for the team to work out a deal, the chances of that happening seem unlikely.
But why? [Read more…]


text:
I like peace & quiet, loud music, drums, foreign foods, weird antiques that no-one understands, tropical fish, gigs, watching the world go by, confounding expectations, long showers with hot water on the back of my neck, lie-ins and surprising people.
I can be random, unpredictable, annoying, frustrating, dependable, supportive, funny, weird and intense. I can overthink things and/or benefit from a slap on occasion to keep in line/on course.
Oh, and I'd never send someone an unsolicited photo of my privates. Seriously, do guys on here do that as a chat-up technique??


text:
Men's Health
Anabolic Steroids - References
Other Works Consulted
Hagen TJ (2007). Medical aspects of sports medicine. In PJ McMahon, ed., Current Diagnosis and Treatment in Sports Medicine, pp. 1–27. New York: McGraw-Hill.
National Institute on Drug Abuse (2006). Research Report Series—Anabolic Steroid Abuse. Available online: http://www.drugabuse.gov/publications/research-reports/anabolic-steroid-abuse.
Pope HG, Brower KJ (2008). Treatment of anabolic-androgenic steroid-related disorders. In M Galanter, HD Kleber, eds., American Psychiatric Publishing Textbook of Substance Abuse Treatment, 4th ed., pp. 237–245. Washington, DC: American Psychiatric Publishing.
Pope HG, Brower KJ (2009). Anabolic–androgenic steroid-related disorders. In BJ Sadock et al., eds., Kaplan and Sadock's Comprehensive Textbook of Psychiatry, 9th ed., vol. 1, pp. 1419–1431. Philadelphia: Lippincott Williams and Wilkins.
In this article
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise
Anabolic Steroids Topics
Today on WebMD
Loaded with tips to help you avoid food allergy triggers.
Sending your email...
This feature is temporarily unavailable. Please try again later.
Now check your email account on your mobile phone to download your new app.


text: The Sword of Omens wiki last edited by NightFang on 09/01/13 05:36AM View full history Sword of OmensThe Sword of Omens is the legendary sword wielded by the leader of the Thundercats. The sword is believed to be the source of the Thundercats power. In the center of the hilt lies the Eye of Thudera, a mystical jewel that is sought after by many such as the mutants of Plundarr and Mumm-Ra. The Eye is red with a black slit down the middle (like a cat's eye) The Sword of Omens was passed to Lion-O by his father (safeguarded by Jaga until Lion-O was of age). The sword has many great abilities:The sword of omen changes sizes starting as a compact blade but extends out to several feet.It can protect the wielder with a force field.The sword never dulls and has been known to cut through the strongest of stones.In times of need the Eye will imbue the sword with great amounts of energy to create a devastating blow when it hits its mark.It also will warn the wielder when danger approaches.When need be it can be used to see far off places or find danger, giving its wielded "sight beyond sight."Also when the wielder says "Thunder, Thunder, Thunder, Thundercats HO!" The eye sends forth a large red catsignal to summon other Thundercats to aide Lion-o.The sword also has its drawbacks, one of which is it is only useful against evil, and can not be used for hunting or just for pointless killing. If it is used to attack another member of the Thundercats the blade will break, initiating what is known as the curse of Balthas, releasing all its energy. The only way to regain the power is to reforge it in star fire.


text:
by Jim Ridley
At Ombi this Sunday, Sept. 14, at 6 p.m., Hoyt Hill and Village Wines will host a tasting of Nicolas Potel Burgundies ranging in price from $13.99 to $89.99. On the docket: the 2006 Potel-Aviron Beaujolais Villages, the 2006 Potel-Aviron Julienas, the 2006 Potel Cuvee Gerard Pinot Noir, the 2006 Potel Volnay Vieilles Vignes, the 2006 Potel Nuits St.-Georges 1er Cru Les Pruliers, the 2005 Potel Pommard 1er Cru Les Fremiers, the 2006 Potel Pommard 1er Cru Rugiens, and the 2006 Potel Gevrey-Chambertin.
The Burgundy Report was especially complimentary of the Volnay Vieilles Vignes: "The nose is wide with a nice complexity of dried berries; cranberry, red currant and black cherries—very nice. The palate has good intensity and a background of ripe tannin." Admission for the tasting is $10, and anyone who stays for dinner gets a 10 percent discount.
Should you have plans, Hill will host another wine tasting 6 p.m. Tuesday, Sept. 16, at Ombi, this time featuring Roda Spanish wines. Then, at 6 p.m. Sept. 22, Hill will host a tasting of wines from New Zealand's Nobilo Wine Group with professional golfer Frank Nobilo in attendance. (Nobilo, as it turns out, is related to the winery's founder and now serves officially as a brand ambassador.) Call 320-5350 for reservations.
Showing 1-2 of 2


text:
DEFINITION of 'Net Debt To Estimated Valuation'
A ratio comparing the net value of a municipal bond issue to the estimated market value of the property secured by the debt. This ratio can differ significantly from a municipal bond's net debt to assessed valuation if real-estate prices for the municipality's holdings incur large increases or decreases.
INVESTOPEDIA EXPLAINS 'Net Debt To Estimated Valuation'
One of the factors that determines the quality of a municipal bond issue is the lower an organization's debt is relative to the estimated market value of its property, the less risky its bonds are deemed to be since there is less risk the government would not have the ability to finance repayment of the bond issue.
Real EstateLand plus anything on it, including buildings and natural resources.
Assessed ValueThe dollar value assigned to a property for purposes of measuring ...
Bond RatingA grade given to bonds that indicates their credit quality. Private ...
AssessorA local government official who determines the value of a property ...
Municipal BondA debt security issued by a state, municipality or county to ...
Net Debt To Assessed ValuationIn a municipal bond issue, a ratio measuring the value of the ...
Where can I buy government bonds?The type of bond determines where you can purchase it, so you need to decide which type of bond you would like to purchase ... Read Full Answer >>
Why is term structure theory of importance to economists?The term structure theory, also known as the term structure of interest rates, is important to economists because it lets ... Read Full Answer >>
Where can I find year-to-date (YTD) returns for benchmarks?Benchmarks are securities or groups of securities against which investment performance is analyzed. Examples of popular equity ... Read Full Answer >>
What is the effective interest method of amortization?The effective interest method is an accounting practice used for discounting a bond. This method is used for bonds sold at ... Read Full Answer >>
Under what circumstances would someone enter into a repurchase agreement?In finance, a repurchase agreement represents a contract between two parties, where one party sells a security to the other ... Read Full Answer >>
What are the main risks to the economy of a country that has implemented a policy ...The main risk to the economy of a country that has implemented a policy of austerity is the potential for a self-reinforcing, ... Read Full Answer >>
Bonds & Fixed Income
The Basics Of Municipal BondsInvesting in these bonds may offer a tax-free income stream but they are not without risks.
Weighing The Tax Benefits Of Municipal SecuritiesFind out how to determine whether the tax exemption offered by "munis" benefits you.
Explaining Term DepositsA term deposit (more often called a certificate of deposit or CD) is a deposit account that is made for a specific period of time.
What's a Maturity Date?Maturity date is the final date when any remaining principal and any unpaid interest are due on a debt.
Worried About Stocks? Try on ConvertiblesConvertibles are a good hedge against equity market risk (if you're o.k. with losing a bit of upside potential).
Stock Analysis
Playing Rising Rates with Ultra-Short Term BondsWith rising rates likely, investors may want to consider adding a dose of ultra-short bonds to their portfolios. Here are some ETFs to consider.
Why Investors Are Bailing on Bond ETFsInvestors are fleeing bond ETFs. Should you follow the herd? Hint: It depends on the type of bond.
Is a Bond Market Selloff Coming?A big investment management company is concerned about bond market conditions and allocating more capital to cash. Should you follow?
Credit & Loans
What is a Syndicated Loan?A syndicated loan is one that involves a group of lenders (called the syndicate) who pool their lending resources to make a loan.
Investing Basics
What is an Asset-Backed Security?An asset-backed security (ABS) is a debt security collateralized by a pool of assets.


text:
The North Face Arbulo T-Shirt - Short-Sleeve - Boys'View Larger Image
Given that it dries fast, blocks harmful sun, stretches, and feels great against his skin, The North Face Boys' Arbulo T-Shirt is sure to be a great asset to your young man's active attire.
Share your thoughts
What do you think of the
The North Face Arbulo T-Shirt - Short-Sleeve - Boys'
? Share a...
Now review from the App. Download


text:
Nathalia Alvares
Sorry, no videos found
Your membership in this group is pending until moderator approval
Nathalia Alvares
Created by Nathalia Alvares
Browse This Group
Related RSS Feeds
This is a Vimeo Group. Groups allow you to create mini communities around the things you like. Check out other interesting groups.


text:
Tuesday, June 30
By DJ Big Bink
Full Story »
By Miranda Ashley
By Jeff Mays
By mycolumbuspower Staff
By D.L. Chandler
By HelloBeautifulStaff
By ronekholland
By Shamika Sanders, Staff Writer
By Nia Noelle
By Danielle Young, Associate Editor
Copyright ©2015,
Interactive One, LLC . All Rights Reserved
Powered by WordPress.com VIP
Get every new post delivered to your Inbox.
Join 610 other followers


text:
Is it possible to establish connection between Galaxy Nexus Jelly Bean (4.1.1.) mobile and any regular desktop contactless reader (ISO 14443 A/B)?
As I know, android does not support card emulation mode, so it should be done only by p2p mode. Is p2p based on ISO 14443, so any reader can be used, or it needs also a specific NFC chip, not the standard ISO14443 chip used in older readers?


text:
8 years of experience
Suite 640
New York, NY 10032 Phone number & directions
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Joshua Willey:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
The overall average patient rating of Dr. Joshua Willey is Average.
Specialties & Research
Dr. Joshua Willey, MD, MS is board certified in Neurology and Vascular Neurology.
- He has special expertise in 6 areas:
- Alzheimer Disease
- Basal Ganglia Cerebrovascular Disease
- Epilepsy
- Migraine Disorders
- Multiple Sclerosis (MS)
- Stroke
Education & Awards
Dr. Willey graduated from Columbia University, New York. He has 2 awards.
Dr. Willey has 9 hospital affiliations:
- NewYork-Presbyterian / Weill Cornell
- New York Presbyterian Hospital / Columbia
- Spanish
Similar doctors nearby
Dr. Claudia Chiriboga
Dr. Carolyn Britton
Dr. Alison Pack
Dr. Claire Riley
Dr. Megan Moran
Dr. Kathleen Poston
- Additional Information
- Dr. Joshua Zebadiah Willey MD and MS is a male Neurologist, has 8 years of experience and practices in Neurology and Vascular Neurology.
- Where does Dr. Joshua Z. Willey practice?
- Dr. Joshua Willey has 1 office location.
Dr. Joshua Willey practices Neurology and Vascular Neurology near New York, NY.
See New York Neurologists.


text:
Cottage Location 3 bed room Floor plan
Grounds were beautiful. Cottages were nicely spaced with most having some view of the sea. Staff were very pleasant and helpful. Waimea is a nice small town with local flavour and convenient to amazing long beaches and the Waimea Canyon
Kitchen cupboards and frig could use some fresh paint
Excellent service, very nicely appointed rooms, truly oceanfront experience without the gaudy mega resort layout to navigate to get a great view and easy beach access. We had a garden view room, but unlike big hotels where that means a view of the parking lot, this faced a nicely manicured and quiet lawn area, and all you had to do was step out and you could see the ocean. Every time we passed the big vacation club next door with the screaming kids, aqua-aerobics, and vacationers packed like sardines next to each other, I was grateful that I had booked this place.
Pool bar was not open for many hours, pool was too warm and shallow for any real swimming, and it would be nice if there was self parking allowed, but it's a small hotel, and I get they don't have the space!
We Really liked the easy access to all the amenities. Large resorts are a drain on a laid back vacation... Large resort this is NOT. We really enjoyed being just steps away from the beach and pool area. We would definitely come back!!
The reviews for Red Salt sounded astounding. We are there our first night and wasn't impressed. The food was definitely okay but just not as astounding as the reviews led us to believe.
The location was convenient to where I needed to be. The staff was friendly.
The building I stayed in was quite far from the main desk area and the valet car pick up area.
We spent one night and two days on Kauai while visiting family on Oahu. The Sheraton was perfect for this. We were able to check in early and to check out late, making the most of our little time on the island. The room was clean, bed super comfortable and the staff were all helpful and friendly.
Like most resorts, most things on the grounds were pretty expensive.
The room was spacious, clean, and very well-equipped with a full kitchen with all the appliances and a washer/dryer. The staff was very friendly and helpful.
The public spaces are under construction.
Could have been more honest about construction.
The pools and fitness center were great.
The room decor was dated and food prices were extremely unreasonable. We paid $32 for a garden salad with 4oz of chicken.
location and service
high pricei booked the fifth night free but they didn't do itI talked to front desk they say we can't do any thingthere was no person to make descion
Staff and location
The door kept getting stuck.
Great location with beautiful swimmable beach right in front. Very close to Restaurants and grounds are beautiful.
Extremely late check-in 4:00 pm,early check-out 10:30 am. For the price you should have a bit more time in the room. Thankfully we did not have a room with pool or ocean view as those rooms seemed to be the loudest for the roosters, but we still heard.
Here's why:
We're not the seller
At KAYAK we don't set prices, so it's not possible for us to guarantee what other companies are selling.
We aggregate tonnes of data for you
Our service lets you quickly and easily compare results from hundreds of travel sites at once. In this sense, KAYAK is a search engine and we don't guarantee prices we find.
Why aren't prices accurate 100% of the time?
Prices on airline seats, hotel rooms and car hires can change frequently. Several people may also be trying to buy the same travel option simultaneously. As a result, you may find on occasion that certain prices are no longer available.
More questions or if you have a bad price to report to us
Please send us an
and someone from our team will get back to you promptly.


text:
Helsinki Blood by James Thompson
Things were pretty grim when we last saw Finnish Inspector Kari Vaara and his crew at the end of Helsinki White. Though they'd brought the high profile Lisbet Söderlund case to a conclusion–more or less–it was not without great cost, both personally and professionally.
Already physically battered from previous years on the job (Snow Angels, Lucifer's Tears) and emotionally numb as a side effect of surgery to remove a brain tumor, Vaara once again suffered debilitating gunshot injuries to the knee and jaw. His right-hand man, the über intelligent if slightly unstable Milo Nieminien, was also left crippled by a gunshot to the wrist, while Vaara's wife, Kate, was forced to take an action so extreme it has left her with post-traumatic stress disorder.
The only one who escaped relatively unscathed was the team's third member, Sulo "Sweetness" Polvinen, though Sweetness was already carrying around a drinking problem, one which hasn't gotten any better in the aftermath. Of course, the team also managed to make ten million in ransom money "disappear," and that's going a long way toward easing their respective pain.
Until, that is, Kate finally snaps and runs off back home to America, and the people Vaara and his team have made enemies of–and their numbers are legion–decide it's time to start pushing back. Now Vaara must once again rally his dysfunctional team around him, this time with the goal of getting out from under the sword hanging over their heads once and for all…whatever it takes.


text:
0 item
Now your mouse pad can be as unique as you and your family are. Combine up to 20 photos to create a collage that will tell a story and brighten any desk.
Can't decide on your favorite photo? Now you don't have to! Use up to 20 photos to tell a story with this unique photo collage mousepad. Made with high-density black foam and a tough, stain-resistant, inter-woven cloth cover. Personalize with a single photo. High-density foam construction stands up to everyday wear and tear. Measures 9.125" x 8.25".
At Rite Aid, we provide you with the support, products, pharmacy services, and the
wellness+ with Plenti saving opportunities you need to keep your whole family healthy. With us, it's personal.
© 2001-2015 Rite Aid Corp. All rights reserved


text:
Telephone & Addresses
(1 - 4 from 111
Christine Ross, Escondido, US, W El Norte Pkwy, Apt 155
View Christine's social profiles and photos on Facebook, MySpace, and +40 Networks.
Christine Ross, New York, US, E 83rd St
View Christine's social profiles and photos on Facebook, MySpace, and +40 Networks.
Christine Ross, Pampa, US, Lynn St
View Christine's social profiles and photos on Facebook, MySpace, and +40 Networks.
Christine A Ross (Age: 38)
11731 East Northport NY
Yellow Page contacts
Network Profiles
(1 - 4 from 218
LinkedIn: Christine Ross - New Zealand | LinkedIn
View Christine Ross's (New Zealand) professional profile on LinkedIn. LinkedIn is the world's largest business network, helping professionals like Christine Ross ...
lastFM: (diddybub1949)
Age: 65, female
fotocommunity: Anja Christine Roß
Berlin, 13 Pictures with 194 Comments, since 07/2013
USTA Leagues
Discover what 330,000 USTA League players already know and join the country's largest recreational tennis league – USTA League!
Business Profiles
(1 - 4 from 7
Xing: Christine Roß PREMIUM Premium Welche Vorteile hat diePremium-Mitgliedschaft? MODERATOR Moderator Was ist ein Moderator? AMBASSADOR Ambassador Was ist ein Ambassador? XPERT Xpert Was ist ein Xpert?
Accounting / Frankfurt am Main, Deutschland
Xing: Christine Ross PREMIUM Premium Welche Vorteile hat diePremium-Mitgliedschaft? MODERATOR Moderator Was ist ein Moderator? AMBASSADOR Ambassador Was ist ein Ambassador? XPERT Xpert Was ist ein Xpert?
CEO / Virginia Beach, Vereinigte Staaten
Seven Simple Steps to Create Abundance
Seven Simple Steps to Create Abundance. By Christine D. Ross ... freedom. You may be able to grasp this idea better if you understand the ...
Private Homepages
Christine Ross Makeup Artist portfolio books showcasing her work on studio sets and commercial sets and samples of makeup on women of all ages.
Christine Ross
Vitajte na našom webe. Žijeme v mestách a ďaleko od matky prírody. Nie veľmi často máme príležitosť tešiť sa z krásnych a unikátnych vecí, ktoré nám ponúka.
Anja Christine Roß
Please help and click here: http://www.yumpu.com/de/document/view/16528545/anja-christine-ross. From 1408 Views to 1500 Views untill 23h. Better 22h 30 ...
Christine Ross at Longwood University - RateMyProfessors.com
Rating and reviews for Professor Christine Ross from Longwood University Farmville, VA United States.
New Jersey Highlands Council | Christine Ross
Christine Ross at McGill University - RateMyProfessors.com
Rating and reviews for Professor Christine Ross from McGill University Montreal, QC Canada.
(1 - 4 from 83
classmates: Christine Ross
Stobart High School, Duck Lake, SK, 1988-1992
classmates: Christine Ross
Lindsay High School, Lindsay, TX, 2005-2009
classmates: Christine Ross
Brooke High School, Wellsburg, WV, 1970-1974
ratemyteachers: Christine Ross - Crieff High School | RateMyTeachers.com
Rate Christine Ross from Crieff High School in Crieff on RateMyTeachers.com
Celebrities & Politicians
IMDB Filmography: Christine Ross - IMDb
Christine Ross, Self: Working Lunch
Bad news
(1 - 4 from 17
legacy.com: Christine Ross
Christine Ross -FORT VALLEY - Services for Christine Ross will be 1P.M., Saturday, April 19 at Shiloh Baptist Church; burial in Willowlake Memorial. -Survivors; children, Gloria
legacy.com: Christine Ross
Christine Ross, 79, beloved mother and grandmother, passed away Friday, May 14, 2010. Funeral: 1 p.m. Wednesday at Salem Baptist Church, 3400 Mitchell Blvd., the Rev. A.V.
legacy.com: Christine Ross
Mrs. Christine Ross, 78, Kansas City, MO, passed away November 9, 2002, at Myers Nursing Home. Funeral services will be 11 a.m. Friday, November 15, at Spruce St. Matthews Baptist
legacy.com: Christine Ross
Mrs. Christine Ross, 78, Kansas City, MO, passed away Saturday, November 9, 2002, at Myers Nursing Home. Funeral services will be 11 a.m. Friday, November 15, 2002, at Progressive
Christine D. (Ross) Ring (born 1967) - Genealogy and History
Christine D. (Ross) Ring, born on ca. 1967, family history photos and genealogy at AncientFaces.
Christine D Ross in the 1940 Census | Ancestry.com
View Christine D Ross's 1940 US census record to find family members, occupation details & more. Access is free so discover Christine D's story today.
CHRISTINE ROSS - people search, genealogy, find deceased relatives...
CHRISTINE ROSS - people search, genealogy, find deceased relatives and locate ancestors
Obituary For: Dr. Karen Christine Ross-Taylor | Low Country Cremation...
St. Simons Island. Dr. Karen Christine Ross-Taylor, age 58 passed away Monday, April 29, 2013 at her residence with her loving husband by ...
Books & Literature
(1 - 4 from 6
Child Care Quality Matters: How Conclusions May Vary With Context -...
John M. Love, Linda Harrison, Abraham Sagi-Schwartz, Marinus H. Van IJzendoorn, Christine Ross, Judy A. Ungerer, Helen Raikes, Christy Brady-Smith,
Books by Christine Ross (Author of In a Dark, Dark Wood)
Christine Ross has 28 books on Goodreads with 70 ratings. Christine Ross's most popular book is In a Dark, Dark Wood (The Story box).
The Aesthetics of Disengagement — University of Minnesota Press
The Aesthetics of Disengagement shows how contemporary art is a powerful player in the articulation of depression in Western culture. Christine Ross examines ...
Intergenerational Christian Formation: Bringing the Whole Church...
One generation commends your works to another; they tell of your mighty acts. Psalm 145:4 Most churches and faith communities segment their ministries by age...
Related Documents
CHRISTINE D. ROSS. State Certified Real Estate Appraiser, FHA Certified. EXPERIENCE. Appraise various types of residential properties, income residential, ...
Scientific Publications
Christine Ross
View Christine Ross's professional profile. Publications: 12 | Citations: 1 Field Rating: 1. Fields of study: Political Science
Video & Audio
Christine Ross et Olivia Boudeau : Le temps suspendu on Vimeo
Cet événement s'inscrit dans le cadre du Cycle de conférences et de conversations L'art contemporain entre le temps et l'histoire, du 16 janvier au 23 mai…
Expert Tax Advice - Christine Ross (SG Hambros) - YouTube
In response to the new UK top tax rate, Christine Ross, Head Financial Planning for SG Hambros, gives expert advice on preparing for the 50% world.
Person of the Year winner: Christine Ross | The News-Press ...
Christine Ross is the President and CEO of the Bonita Springs Area Chamber of Commerce. She is pictured on Thursday, December 15, 2011. / Amanda Inscore/news-press
Schenectady County Community College
Misty L. Rogers, Schenectady, NY. Megan E. Rooney, Rotterdam, NY. Christine D. Ross, Rennselear, NY. Chelsea N. Ruchalski, Schenectady, ...
Reports & Statements
(1 - 4 from 6
Wikipedia: Christine Ross - Wikipedia, the free encyclopedia
Christine Ross is a Canadian scholar specializing on contemporary media arts, in particular: the relationship between media, aesthetics and subjectivity; ...
Wikipedia: Andrea Ross - Wikipedia, the free encyclopedia
Andrea Christine Ross (born April 8, 1991) is an American singer and actress. She has been an award-winning lead actress on stage in her local area of Boston ...
Wikipedia: West Mesa Bone Collector – Wikipedia
Der Fall . Am 2. Februar 2009 entdeckte der Hund der Spaziergängerin Christine Ross den Knochen eines Oberschenkels auf dem Grundstück eines verlassenen ...
Rubios invisibility on flood insurance issue drawing questions
14.01.2014 - WASHINGTON - When Christine Ross shows up at Sen. Marco Rubios office Wednesday, shes looking for an answer to a
(1 - 20 from 28
Christine Ross
Biography. Presenter Bios Christine Ross is a New Zealand based communications professional. Formerly a journalist, she has worked for research and ...
Christine Ross 1 | Free Listening on SoundCloud
Christine Ross 1 Christine Ross. Follow Share a track Share. Facebook Twitter Tumblr Email WordPress StumbleUpon Blogger MySpace. Less. Did you know ...
Christine Ross Architect - 11506 3A Hwy, Sanca, BC
Christine Ross Architect - Sanca - phone number, website & address - BC - Architects.
Christine Ross Biography - The Banff Centre
Christine Ross Biography - The Banff Centre Christine Ross is Associate Professor in the Department of Art History and Communication Studies at McGill ...
Christine Ross is awarded the inaugural Artexte Prize for Research in...
Artexte honours Christine Ross, first recipient of the Artexte Prize for Research in Contemporary Art. Christine Ross is Professor and James McG...
Christine Ross wins inaugural Artexte Prize - Canadian Art
Today Montreal's Artexte announced that McGill University professor Christine Ross has won its inaugural Artexte Prize for Research in ...
Christine Ross | BLOUIN ARTINFO
Christine Ross. Cory Arcangel and the Problem of the Depressive Internet Art Bro · The Problem of the Depressive Internet Art Bro. by Joseph Henry.
Christine Ross, MA. Ed. | Felician College, New Jersey Catholic
I began my career in education as a middle school teacher in multiple subject areas, and then became an elementary school principal. While principal, my...
ATG Star of the Week: Christine Ross, University of Florida | Against...
Name Christine Ross Title Scholarly Communications Librarian Organization University of Florida Address P.O. Box 117000, Gainesville, ...
Memories of Old Skelmersdale
Memories of Old Skelmersdale. Here are memories of some Old Skemmers of Skelmersdale. Contents: Chapter 1: "Top o' Lane and T' Miners" by Christine Ross
Residency Program Current Residents - Department of Obstetrics &...
Department of Obstetrics & Gynecology - School of Medicine - UT Health Science Center at San Antonio, Texas. The Department of Obstetrics and Gynecology at...
Mugs of suspects booked into jail in muskogee
Christine Ross
Christine D Ross at Stockton, California specialized in Certified Residential Property Appraiser. Check client reviews or rate Christine Ross.
Christine Ross
Christine Ross. The following is excerpted from an article which appeared in Revue d'art canadienne/Canadian Art Review (RACAR) XXIV:1, 1997; pub. 1999 ...
Akimbo - Events - Dr. Christine Ross, Public Talk: Contemporary Art's...
Canada's online source for visual art information, news and listings
Fiche de personne
Christine Ross is Professor and James McGill Chair in Contemporary Art History in the Department of Art History and Communication Studies at McGill ...
Christine Ross » strategy
Christine Ross, founder, Spider Marketing Solutions, Toronto
Poem by Christine Ross - The Silence of Christmas Morning
THE SILENCE OF CHRISTMAS MORNING ..by Christine Ross in memory of Lucas Christopher Ross 1979 - 2001. The silence of Christmas morning,
Ross, Christine / Welcome
Christine Ross 9th - 12th. Algebra 2 and Algebra 2 PreAP. Room Number: 2311 281-641-7657 firstname.lastname@example.com. Algebra 2 - 1st, 6th, and 7th.
Christine Ross
... Math - Middle Level · Music · PE and Health · Specials - Elementary · Strive · TAG. Skip Navigation Links Monarch K-8 > Faculty and Staff > Christine Ross ...
Related search requests for Christine D. Ross
|James McGill
Michael Ross
John Ross
Forename "Christine" (63383)
Name "D. Ross" (172)
sorted by relevance / date


text:
Book your room at Koh Jum Resort
Cottage (Bamboo)Max Occupancy: 3 guests (up to 2 children, 1 infant)
House (Teak Wood)Max Occupancy: 3 guests (up to 2 children, 1 infant)
Villa (Teakwood)Max Occupancy: 3 guests (up to 2 children, 1 infant)
Villa, BeachfrontMax Occupancy: 3 guests (up to 2 children, 1 infant)
Get an overview of this hotelBeachfront resort with calming spa services
This Ko Jum resort is by the sea and is set on its own private white sand beach within easy reach of Ko Jum Beach. Regional attractions also include Kawkwang Beach and Sala Dan Community School.
Resort Features
Along with a private beach, this resort has a restaurant and an outdoor pool. WiFi in public areas is free. Additionally, a bar/lounge, a beach bar, and a poolside bar are onsite.
Room Amenities
All 19 rooms offer furnished balconies, room service, and safes.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
This Ko Jum resort has its very own private beach. Dining options at the resort include a restaurant and a coffee shop/café. Guests can unwind with a drink at one of the resort's bars, which include a beach bar, a poolside bar, and a bar/lounge. A complimentary breakfast is offered. Public areas are equipped with complimentary high-speed wireless Internet access.
This beach resort also offers an outdoor pool, tour/ticket assistance, and a garden.
- Airport transportation - pickup (surcharge)
- Total number of rooms - 19
- Bar/lounge
- Coffee shop or café
- Free breakfast
- Pool umbrellas
- Tours/ticket assistance
- Free WiFi
- Garden
- Poolside bar
- Beach bar
- On private beach
- Restaurant
- Pool sun loungers
- Beach towels
- Outdoor pool
Family Friendly Amenities
- On private beach
- Outdoor pool
- Free Wi-Fi
Available in some public areas: Free WiFi
Room Amenities
- Furnished balcony
- Daily housekeeping
- Private bathroom
- Free toiletries
- In-room safe
- Room service (limited hours)
Where to Eat
A complimentary breakfast is offered.
Ocean Terrace - Overlooking the ocean, this restaurant specializes in international cuisine and serves breakfast, lunch, and dinner.
Room service (during limited hours) is available.
Nearby Things to Do
Recreational amenities at the resort include a private beach and an outdoor pool.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Kayaking nearby
- Scuba diving nearby
- Snorkeling nearby
- Bicycle rentals on site
Spa Services
- Massages
Hotel Policies
Check-in time starts at 7:30 AM
Check-out time is noon
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No cribs (infant beds) available
- New Year's Eve gala dinner fee
- Airport shuttle fee: THB 3000 per vehicle (one-way)
- Rollaway bed fee: THB 845.00 per night
We should mention
A fee for a mandatory New Year's Eve gala dinner is included in the total price displayed for stays on 31 December. One child 8 years old or younger stays free when occupying the parent or guardian's room, using existing bedding.


text:
Previous versions of my app have used the Settings.bundle method to have some user preferences managed in the (external) settings app. I've done away with that now, but I'd like to be able to de-register my application so that old users who upgrade don't have a useless entry in their settings app. Any idea if this is possible? Thanks.
Take the 2-minute tour ×
Stack Overflow is a question and answer site for professional and enthusiast programmers. It's 100% free, no registration required.
Delete the Settings.bundle file and Move to Trash, Clean All Targets, Then Build and Go.
Have you tried removing the Settings.bundle?


text:
30 Minutes Facial Massage -
Depending on your will / concerns appropriate Aromatherapy oils are mixed with either a cream or oil base medium.
Can be preformed as a treatment on its own or can be incorporated in any of the facials on offer or any treatment you would like.
Please come in loose comfortable clothing
Please add an extra 15-20 on your first visit for a consultation. (which means if your treatment is for 1 - you come at 1 then we do the consultation form and only after that will the treatment start, there is no need to come earlier)
Treatment Room - Beauty
Online bookings let you pick date/time for your visit.
If you purchase an eVoucher you will need to book with the venue directly.
Our old Wahanda Gift Vouchers can still be redeemed at over 3,000 locations. Use them to pay as you would with cash. Please note, the Wahanda Gift Voucher's successor – the Wahanda Gift Card – can only be used for online purchases.


text:
March 18, 2013
March Madness has descended upon the nation once again, and our friends at the Mizzou Network have put together a bracket of their own: a 16-video list of the best Mizzou men's basketball plays of the year. Tiger fans are encouraged to vote every day for their favorite videos, and the winners will advance to the next day's round.
Voting begins Monday with eight "first-round" matchups, and continues daily until the top play - earning Play of the Year honors - is announced Thursday, just before tipoff of Mizzou's NCAA Second Round game vs. Colorado State.
View today's eight videos, then vote at the bottom of this page, or you can just skip there now!
#1 vs. #16: Pressey's Knees vs. Brown's "And One"
#8 vs. #9: Keion's Dunk vs. Flip Behind-the-back
#5 vs. #12: Earnest vs. A.O.
#4 vs. #13: Alex's Ole Miss Dunk vs. Keion's S.C. Alley-Oop
#6 vs. #11: Flip Coast-to-Coast vs. L-Bo's Put-Back
#3 vs. #14: Bowers Dunks on Hogs vs. Stefan Dunkovic
#7 vs. #10: Alley-Oop, Braggin' Rights Style vs. #SECVille Dunktacular
#2 vs. #15: Keion Goes 360 vs. Earnest's 3
More Headlines
Andersons Kick Off Tigers on the Prowl Charity
Mizzou Men's Basketball head coach Kim Anderson and wife, Melissa, are set to serve as campaign...
Top Shooting Guard Walton Signs with Mizzou Hoops
Mizzou Men's Basketball head coach Kim Anderson has announced the signing of 6-3 guard K.J....
Mizzou Men's Basketball Program Mourns Passing ...
The Mizzou Men's Basketball program and head coach Kim Anderson were saddened today to learn of...
Former Tiger Tate Joins Anderson's Mizzou...
Corey Tate, who amassed more than 250 victories in 11 seasons as head coach at Mineral Area...
Mizzou Adds Highly Touted JUCO Teammate Hoopsters
Mizzou Men's Basketball head coach Kim Anderson has announced the signing of 6-2 guard Martavian ...
Men's Basketball Eyes Next Season at Annual...
Mizzou Men's Basketball held its annual banquet on Monday, April 20, at Mizzou Arena, with the...
#LevelUp: Phillips Already Embracing Life as a ...
Mizzou Men's Basketball added a new signee, 5-11 guard Terrence Phillips, to its 2015 recruiting ...
Phillips Signs with Mizzou Men's Basketball
Mizzou Men's Basketball head coach Kim Anderson has announced the signing of Terrence Phillips to...
Online Stores
Official StoreOfficial Online
AUCTIONSOfficial Mobile APP
Top Videos
- Schedules


text:
G2D Games
Most Played Games
New Games
Dressup Games
Makeover Games
Girls Games
Celebrity Games
Cool Games
Cooking Games
Baby Games
Fun Games
Game Name
Honeymoon Travel Couple
Dressup Games
Game Tags
Couple,Dress up,Girls,Outfits,Honeymoon,Beauty,Modern
Click Here to Play
Game Details :
The both boys are very nice. But which boy would the girl like best? Choose one and dress up the girl with beautiful clothes. They will have a honeymoon travel.
New Games
Winter Streetshot Anim
Barbie Princess Design
Hot 16 Dress Up
Kitty Princess
Peach Princess
Black Laces
Seeing Jewelry
Loose Denim Anime
Bikini Season
Neutral Pastel
Comfy Cozy Anime
Pleated Fashion


text:
The Medical College of Wisconsin will create its new pharmacy school in the college's existing buildings on its Wauwatosa campus.
Medical College of Wisconsin officials have decided to proceed with opening a pharmacy school at the college's Wauwatosa campus with startup costs of about $30 million.
Collaboration is key to the success of the University of Wisconsin-Milwaukee's Innovation Accelerator building. The first building at UWM's budding Innovation Park campus, the accelerator is a convergence in multiple senses.
Two local universities saw leadership shifts midway through the month, bidding "goodbye" to a prolific Marquette University dean and welcoming a new face at Concordia University Wisconsin.
Newaukee's sold-out "Speaker Crawl" drew big names and more than 350 young professionals to the Milwaukee Public Museum Wednesday.
The Medical College of Wisconsin is getting closer to a decision on opening a pharmacy school and the college's board is likely to consider the plan by May.
Mequon officials are reaching out to Concordia University Wisconsin and Columbia St. Mary's to pitch in for construction of a new Interstate 43 interchange at Highland Road.
Interstate 43 will be expanded to six lanes between Glendale and Grafton, and a new interchange will be added at Highland Road in Mequon under a project plan federal officials approved.
Conversion of a historic Pabst Brewing Co. building into housing for international college students gained an important city of Milwaukee approval Monday.
Blue Ribbon Management LLC is seeking city of Milwaukee approval to build a hotel and student housing in a former Pabst Brewing Co. building in The Brewery development.
The Medical College of Wisconsin will explore the feasibility of opening a pharmacy school and the location most likely would not be near Wisconsin's two existing pharmacy schools, which are in Mequon at Concordia University Wisconsin and in Madison at the University of Wisconsin.
Marquette University isn't alone in seeking a presence at the University of Wisconsin-Milwaukee's Innovation Campus in Wauwatosa; it's one of four.
Meanwhile, several Wisconsin colleges competed for high marks among regional universities, based on the newest rankings from U.S. News & World Report.
Concordia University is affiliated with The Lutheran Church-Missouri Synod and is a member of the Concordia University System, a nationwide network of 10 colleges and universities. It is committed to developing its students in mind, body and spirit through its values-based curriculum and emphasizes Christian principles focusing on stewardship, excellence, truth and integrity, global-mindedness, and the integration of faith and learning.
One thing seems to be consistent throughout the state when it comes to master of business administration (MBA) programs: More students are looking to specialize.


text:
India Says Yes Award
Winner for categories:
- Resorts
- Awesome Food
- Excellent Service
65 traveller reviews for Vaity Ropeway ResortWRITE A REVIEW
- Samruddha Shah
- Lives in Dhule
- 1 Review
"One of the best resort with good service"
- Posted 3 months ago
I love this resort. It is luxurious hotel and also in authentic rope way place at hill. Rooms are spacious. Service and food is as good as five star hotel. So you can go for it. It's advantage is, it is near sunset point in Saputara, you love there service and also try rope way.More » « Less
- Was this review useful?
- Be the first to vote.
- Sachin patil
- Lives in Nasik
- 1 Review
"Lake view room, delicious food and a good garden"
- Posted Feb 24, 2015
I visited Saputara for a family vacation and stayed in Vaity Ropeway Resort. This hotel was close to the city with good surroundings. The staff was good, friendly in behaviour and the services were helpful and prompt. The check-in and check-out process was done on time. The veg food that I had ordered at the restaurant was delicious and reasonably priced too. The room that was provided to me was neat and clean with good working amenities and there was a good lake view from the room, there was a garden available at this hotel too. There were no activities or sightseeing games organised at the hotel. Overall, this destination was very good and the hotel sure is worth, like to visit it again and would suggest it to other travellers too.More » « Less
- Was this review useful?
- 4 votes
- Mansi
- Lives in Surat
- 3 Reviews
"Overall cleanliness of the hotel needs to improve"
- Posted Jan 10, 2015
Fabulous location! Sightseeing trip was managed by our own. I traveled there before two years with my family. Location wise, the hotel was situated on the Table top. Overall cleanliness of the hotel was not very good and also level of room was not nice. Surrounding of the hotel was very nice. They provided only veg food there and it was awesome and cost of the food was reasonable. Behaviour of the staff members was very nice and they gave on time services. There was no delay in check-in and check-out facility. Outer look of the hotel was good but inner look was not very nice. There should be renovation in the interior and also they should maintain their room. Room was bit tidy but not spacious and well-maintained. Geyser, AC and TV were available there and they all were in working condition. Bedsheet and other furnishing were not very tidy. Valley view was visible from my room and it was fantastic. Hot and cold water facility was available there all the time. Indoor activities were available there like carom, badminton, etc and I did use them. Money wise, the hotel was value for money. I did not like the overall cleanliness of the hotel. I will not recommend this hotel to other travellers because rooms were not well-maintained. They also arranged the local folk dance activity and it was very nice. I have one suggestion for other travellers that the location and food was fabulous but rooms were not well-maintained. As a destination, Saputara place is fantastic.More » « Less
- Was this review useful?
- 4 votes
- Nikul Amipara
- Lives in Surat
- 1 Review
"Good appearance ; Well maintained rooms"
- Posted Nov 19, 2014
Location of the hotel was good. Staff behaviour was helpful and friendly. Appearance of the hotel was nice. Rooms were spacious, neat, clean, and well maintained. A nice view was visible from hotel rooms. I took only veg food in the hotel. Quality and variety wise, food was good. Check-in and check-out process was not delayed. Hotel was value for money paid. I will recommend this hotel to other travellers. It was a sightseeing trip with my family. Room's tariff was above Rs. 1500 per day.More » « Less
- Was this review useful?
- 4 votes
- Sanjiv
- Lives in Jalgaon
- 1 Review
"Good hotel with many activity"
- Posted Oct 28, 2014
The room was neat, clean and well maintained. We had food in the hotel and it was awesome in terms of quality and taste. Staff behaviour was good and they were friendly in nature. They arranged some activities like table tennis, magic shows and cultural program for guest. There was no difficulty in the hotel. Parking facility was there in the hotel. We didn't ask for transportation facility because we had our own car. I would definitely recommend this hotel to other travellers. This hotel was value for money.More » « Less
- Was this review useful?
- 4 votes
- Pratibha Kulkarni
- Lives in Mumbai
- 1 Review
"Value for money, good hospitality"
- Posted Sep 28, 2014
We stayed there for two days and all the time the hotel was covered with clouds n cold breeze. It was just an amazing experience and we played table tennis after a long time, staff was very polite and good hospitality. Food was average and there was still can be lot of work can be done with the interior, anyway still its value for money for stay.More » « Less
- Was this review useful?
- 5 votes
- Lalit Chowdhary
- Lives in Mumbai
- 1 Review
"Maintenance was very poor in the hotel"
- Posted Sep 26, 2014
Hotel food was good but room cleanliness was very poor. Bed sheets were also dirty there. Outside look of the hotel was not maintained. Overall, things and facilities were not up to the mark at all. Staff behaviour was good in this hotel. They were professional. Very good view was available from the room. Resort quality was not good. Overall, my stay there was very bad. They should improve the quality and cleanliness of rooms. It was fully wastage of money. Saputara is a good place. I visited there with my family before 11 months.More » « Less
- Was this review useful?
- 4 votes
- Suraj Poojary
- Lives in Mumbai
- 1 Review
"Overall good experience ; reasonable hotel"
- Posted Sep 19, 2014
There was no problem in locating the hotel. The staff behaviour and the service good. The overall experience in the hotel was good. The amenities in the room were working properly. The quality of the food in the hotel was good. There was no delay in check-in or check-out. The hotel had a garden and no other activities. I had managed my own sight seeing. The money spent at the hotel was value for money. I would recommend this hotel to other travellers.More » « Less
- Was this review useful?
- 4 votes
- Motisariya Jignesh
- Lives in Surat
- 1 Review
"Hotel with good rooms and staff"
- Posted Sep 15, 2014
Hotel was conveniently located. Location was good. There was no difficulty in locating the hotel. Staff behaviour was good. Room allotted was good. Bed Sheets, pillows, blankets etc were clean. There was good view from the room. Amenities like AC, TV, Geyser etc. were working properly. Food was taken from outside due to sight seeing. There was no delay in check in and check out. Overall it was value for money. There are no suggestions and everything was good. It was a relaxation trip.More » « Less
- Was this review useful?
- 4 votes
- Velliyangiri
- Lives in Surat
- 1 Review
"Excellent location and ambience"
- Posted Sep 9, 2014
I did online booking through travel agent. It was a good picnic spot. There were very few places there in Gujarat to go and see. The rush was there but they will not be able to manage the crowd. They could not manage the restaurant. The taste of the food was very nice but the problem was the managing of the crowd. There was particularly, Punjabi food available but few dishes of Gujarati food were also there. I liked the food. Swimming pool was there. Hotel was located in the main place. It was at walkable distance from the road side and in monsoon this was very nice. It was hill station kind in Gujarat. The behaviour of the staff was good. I took my own vehicle but they provided pickup and drop on chargeable basis. Parking facility was there and it was fine. It was value for money. Saputara as a destination is excellent. Location of the resort was excellent. Ambience of the resort was also excellent. Booking and front office facility was good. Overall services were very good. Food and drink was also very good. I did not explore activities so it was average. Room was good. I went there with my parents for relaxation.More » « Less
- Was this review useful?
- 4 votes
Have you stayed at Vaity Ropeway Resort?
Vaity Ropeway Resort Overview
Vaity Ropeway Resort is located in Saputara. The resort is 172 km away from Dumas Airport in Surat. The nearest railheads are Nashik Road Railway Station, which is 77 km away and Bilimora Railway Station, which is 110 km away.
Rooms and Amenities at Vaity Ropeway Resort
Vaity Ropeway Resort has 40 rooms, out of which 10 are A.C rooms and 30 Non A.C rooms. The resort also has an in-house restaurant. The amenities provided by the resort are Doctor on call, Travel desk, Car rental, Conference hall, Laundry service, Credit cards acceptance and Car parking.
|Facilities at a Glance
Car Rental Facility
Conference Facilities
Doctor on Call
Laundry Service
Parking Facility
Travel Desk
Vaity Ropeway Resort Address
Gujarat - 394720
Are you the business owner?
There are tremendous benefits of signing up with HolidayIQ.com for the CenterStage hotel reputation program.
Manage your listing >


text:
Pizza Salad Recipe
- 1 pound spiral macaroni, cooked and drained
- 3 medium tomatoes, diced and seeded
- 16 ounces cheddar cheese, cubed
- 1 to 2 bunches green onions, sliced
- 3 ounces sliced pepperoni
- 3/4 cup canola oil
- 2/3 cup grated Parmesan cheese
- 1/2 cup red wine vinegar
- 2 teaspoons dried oregano
- 1 teaspoon garlic powder
- 1 teaspoon salt
- 1/4 teaspoon pepper
- Croutons, optional
- In a large bowl, combine macaroni, tomatoes, Cheddar cheese, green onions and pepperoni. In a small bowl, combine oil, Parmesan cheese, vinegar and seasonings. Pour over macaroni mixture; toss to coat. Cover and refrigerate for several hours. Top with croutons just before serving if desired. Yield: 16 servings.
Light-Bodied White Wine
Enjoy this recipe with a light-bodied white wine such as Sauvignon Blanc or Pinot Grigio.
Reviews for Pizza Salad
Sort By :
"Pizza salad was delicious, I prepared it for a bowling banquet & it was a success, several people asked for the recipe. They told me they had tried to make this before but it was never this good. I must say that I cut back on the cheese cubes, I also cut the peperoni in halve."
"I make this all the time. I use a couple bottles of zesty Italian dressing (or regular) then you don't have to use the vinegar, oil, or oregano. I also mince fresh garlic instead of the powder. Works great using salami with pepper jack cheese."
"I want to make this, but I don't have any red wine vinegar. I'm not able to get out to store due to recent surgery. I have white distilled vinegar. Is it ok to use that instead or should I use something else as a substitute for the red wine vinegar? Thanks"
"Yummy! I followed exactly, using turkey pepperoni. I don't dine on swine! This was fast and easy."
"Always called it Pasta Salad but love the addition of Oregano. Will try this! Looks so good!"


text:
Langkawi holds many hidden treasures and the Mat Chinchang rainforest is definitely one of the precious gems on this tropical island. Experience one of the most ancient rainforests by spending 4 hours of jungle trekking through this lush forest that hosts unique species of flora and fauna. Led by an experienced guide, you'll discover up to 400 different species in this dense jungle. Make sure to keep your eyes peeled for exotic animals like flying lemurs, squirrels, civets, snakes, birds, monkeys and more. Have a break with 2 bottles of mineral water and light lunch as well as a leisure bicycle ride that's included with today's deal. Don't forget to bring a camera and a backpack when you go on today's tropical adventure!
What You Get:
Offer 1: (RM99) Child
Offer 2: (RM119) Adult
- 4Hr Jungle Trekking at Mat Chinchang
- Experienced Guide
- 2 Bottles of Mineral Water
- Light Lunch
- Leisure Bicycle Ride
- Insurance included
Travel Period:
• Voucher valid from 28 August 2013 - 23 December 2013
• Reservation must be made within 5 working days from the day of purchase; subject to room availability
Additional Terms & Conditions:
• Tour is based on Sit-In-Coach and English-speaking basis
• Inclusive of all entrance fees and transfers unless stated otherwise
• Pick-up time is at 8.30am
• Pick-up is not applicable for the following hotels: The Datai, Tanjang Rhu Resort, Four Seasons and The Andaman
• Not valid for children aged 5 years and below
• Guests are required to fill up a liability form
• Guests are required to wear proper sports shoes or trekking shoes and long pants
• Printed vouchers must be presented upon redemption for verification purposes
• No refund permitted once voucher is purchased
• No amendments allowed after confirmed reservation; voucher subject to forfeiture for cancellation, no-show or unused voucher
Redemption Instructions:
1) To redeem, email firstname.lastname@example.com with the email subject 'Jungle Trekking Discovery at Matchinchang Mountain' with your:
- Name
- Mobile number
- Email address
- IC number (Malaysian citizens only)
- Attached LivingSocial Vouchers
2) Present printed LivingSocial voucher upon tour pickup
3) Enjoy!


text:
Sable Island horses may face extinction
Many thoughts come to mind when reading this story. The big one is the fact that there will always be arguments as to how animals in an environment affect one another. Whether you are in Canada, the US, Australia – any where there are wild horses, there will always be those who claim horses destroy Full Article
Amazing Horse Head Sculpture Lights up Scottish Skyline
The Kelpies have been a long time in coming. We first posted about them many months ago. At first they looked like an ugly tangle of metal sitting against ...Full Article
No feed? No hay? No barn? You can still adopt a horse!
A great Christmas gift for any horse lover in your family or for that horse loving friend or best of all for yourself. The adopter will receive a framed ...Full Article
Society continues work with vaccine, shelter for Alberta's wild horses
Wildies – as Canadians call their wild horses – have stout supporters much like our own American wild horses do. Contraceptive programs are being looked to as a means ...Full Article
Happy Thanksgiving from Habitat for Horses
Happy Thanksgiving Too many of our national days of celebration get lost in the cornucopia of American consumerism. Even the moments of family togetherness once shared during Thanksgiving have ...Full Article
Fazio: BLM must rethink wild horses, contraception
From: Casper Star Tribune By: Patricia M Fazio, PhD Is Wyoming waking up to the reality of our nation's unworkable approach to managing wild horses? The horse issue is ...Full Article
Drink Budweiser or it will kill these horses
We can only hope that this article is joking. The Budweiser Clydesdales are so well known, surely the Budweiser company could sell them, if they are deemed unprofitable. (Caution ...Full Article
Can a stallion save the Corolla Wild Horses from extinction?
From: WTKR By: Todd Corillo Can a stallion named Gus save the Corolla Wild Horses from extinction? Corolla, North Carolina (WTKR) – A young stallion named Gus just might ...Full Article
Woman Teaches Horse Scared of Water How To Conquer His Fear (Video)
From: Reshareworthy Anna Paterek was riding her horse Magic through the woods when they approached a calm river. Magic immediately stopped. The horse was frightened to step into the ...Full Article
Horse Pants – The Hottest Innovation in Horsewear (Video)
A pick-me-up laugh-out-loud for your Pre-Monday Commute. Jimmy Kimmel pitches his great new idea to Shark Tank: Horse Pants. (Thank you to everyone who shared this on Facebook – ...Full Article