text:
FIG. 1 is a front elevational view of a set of containers embodying our new design;
FIG. 2 is a top, front, right side perspective view of the first container in the set shown in FIG. 1;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a left side elevational view thereof, shown at an enlarged scale;
FIG. 5 is a right side elevational view of the bottle of FIG. 2;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.
The broken lines shown in the drawings are for illustrative purposes only and form no part of the claimed design.

subset: commoncrawl


text:
Photo Special10 Best Celeb Quotes This Week
Justin Bieber gets his "Boyfriend" buzz on, plus more from Madonna, Jennifer Lawrence and other stars
Credit: Andrew Kelly/Reuters/Landov
Updated: Friday Mar 30, 2012 | 06:00 AM EDT By: Christie LaRusso
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text:
Processing RAW files with RawTherapee
Chromatic Scales
Chromatic aberrations can be removed with the use of Remove chromatic aberration. Depending on whether you are removing a red or blue cast, you can move the slider to the left or right until the color cast disappears.
In the end, all photographers want to make the best of their images. Often this is done by selecting the perfect detail from a photograph. Configuration elements to help you do so are available below Detail. For easier orientation, the program will show you various guides, such as Golden Section or Diagonal (Figure 4). The Keep aspect option, which is enabled by default, keeps the detail in a photo-compatible format. You can enable the selection by clicking Select detail, which you can then move to any position in the image by pressing the Shift key and holding down the left mouse button.
RawTherapee is easily the best manipulation tool for RAW images on Linux right now. It can handle any format and holds its own with commercial programs. The lack of a batch mode and the broken color noise filter preview are the only minor niggles right now.
- RawTherapee: http://www.rawtherapee.com
- DCraw: http://www.cybercom.net/~dcoffin/dcraw/
- RAW converters compared: http://www.rawtherapee.com/RAW_Compare/
- RawTherapee manual: http://www.rawtherapee.com/?mitem=6
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text:
Chanel Iman On Chic: 12 Electrifying Looks view
Breakout Style Star: Kiersey Clemons' Top Looks view
Janet Jackson's Top 25 Looks Ever view
The sketches, design inspiration and the diva herself live on stage.
A close-up of Stuart Weitzman's ankle booties paired with the Givenchy costume....
A close-up of Stuart Weitzman's ankle booties paired with the Givenchy costume. The designer has customized footwear for Beyoncé's past two tours, The Beyoncé Experience and I Am...Tour as well as other special performances.
"Creating footwear for Beyoncé's shows has been one of my most inspiring projects. She and her entire team know exactly what they need, always focusing on the fashion and the function of the styles that will be worn," said designer Stuart Weitzman.
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text:
Luongo doesn't care about being the NHL's fourth-most overrated player
Jan 12, 2012, 4:42 PM EDT
Another day, another person not thrilled with Sports Illustrated's anonymous NHL players poll.
Today it was Vancouver Canucks goalie Roberto Luongo sharing his thoughts on the poll, which asked 161 NHLers to pick the league's most overrated players. Luongo finished fourth on the list, behind Toronto's Dion Phaneuf, Washington's Alex Ovechkin and Montreal's Scott Gomez.
"I don't care and I really don't pay attention," Luongo told the Vancouver Province.
Luongo might not care or pay attention, but his teammates seem to, at least a little. The Canucks featured prominently on the most overrated list (Ryan Kesler finished ninth) and that drew the ire of team captain Henrik Sedin.
"It bothers me that they have a poll," Sedin said. "How are they overrated? None of those on the list are bad players. I was really surprised by the poll and who was on it. Me and Danny were the most overrated in Sweden before we came over and it's nothing we cared about, and I hope Lui and Kes don't care. Do the best player or the MVP."
That Luongo made the overrated list shouldn't come as much of a surprise
because he is quite overrated. Sports Illustrated did the same poll in 2010 (though based on a survey of 272 NHLers) and Luongo was one of three goalies to get more than a single vote.
- bigtganks - Jan 12, 2012 at 4:51 PM
But let's not talk about Gomez, Ovechkin, or Phanuef…
- gooterbaby - Jan 12, 2012 at 5:15 PM
They don't play for the leagues most hated team.
- thatsdoinit - Jan 12, 2012 at 4:53 PM
Overrated? Questionable.
Overpaid? Absolutely.
- bigtganks - Jan 12, 2012 at 5:10 PM
Mike Halford: "…another person not thrilled with Sports Illustrated's anonymous NHL players poll."
Luongo: "I don't care and I really don't pay attention,"
Explain your logic please…
- Mike Halford - Jan 12, 2012 at 5:13 PM
Well, Luongo didn't sound thrilled. Pretty simple.
Another person not thrilled? Henrik Sedin.
"It bothers me that they have a poll," Sedin said.
- bigtganks - Jan 12, 2012 at 5:37 PM
You eluded it was Luongo.
"Another day, another person not thrilled with Sports Illustrated's anonymous NHL players poll.
Today it was Vancouver Canucks goalie Roberto Luongo"
He said he didn't care. That's my point. I see yours with Sedin though.
- blomfeld - Jan 13, 2012 at 1:56 AM
Luongo is "on record" for not caring about who he wins the cup with … it could be with the Mogadishu Bulldogs for all he cares … just as long as "he" wins the cup …
- haterzgonahate - Jan 12, 2012 at 5:24 PM
Jarome Iginla was on that poll.. which pretty much sums it up and speaks to the credibility of said poll. and Kesler? really? the guy just had his breakout season.. practically carried his team through round 2 of the playoffs last year..
lets do a quick poll on who thinks that poll is a joke. all in favor? thumbs up!
- whatswellydoing - Jan 12, 2012 at 5:27 PM
I don't really get how he's overrated. He's one of the biggest whipping boys in the league. Same goes for Gomez and several other players on the list. When I think overrated, I think players who are praised more than they should be.
- canuckdude82 - Jan 12, 2012 at 6:00 PM
I don't really get how he's overrated. He's one of the biggest whipping boys in the league. Same goes for Gomez and several other players on the list. When I think overrated, I think players who are praised more than they should be.
Because this is what overrated does mean. This poll looks more like a popularity contest…..
- waraggie - Jan 12, 2012 at 6:32 PM
As a Canucks fan, he is definitely overpaid and, combined with being a Canuck, that makes him overrated. I agree that a goalie making that kind of money should show up in big games…hell, at least play. I do think his heart isn't in the game from time to time. But it is what it is. He's playing well now and that's all that matters.
But the list is completely bogus. So is the way it is reported. Did anyone ask Ovi what he thought? How about Iginla? Chris Pronger is sitting at home with a concussion….think he cares?
- soxpatsbscelts - Jan 12, 2012 at 7:45 PM
Didn't even play in Boston. What a punk.
- gnazarov - Jan 13, 2012 at 3:14 PM
Not to mention he's a complete d-bag as well.
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New eBook is Released About THE ALZHEIMER'S EPIDEMIC
Author Danton H. O'Day, PhD has just released a new eBook, "The Alzheimer's Epidemic-Searching for Causes and a Cure" (US$14.99; ISBN 978-1-4566-1356-3), in which he provides breakthrough insight on Alzheimer's disease and the increasing, threatening Alzheimer's epidemic. With 80 original figures (most in colour) and 15 tables in 16 detailed chapters, O'Day's new book goes well beyond what the average person reads in newspapers and online. By reviewing the latest international research it delves deeply into our understanding of the dreaded descent into darkness that characterizes this terrifying disease.
There is a growing concern worldwide that the Alzheimer's epidemic will be a devastating economic problem. Its effect on healthcare resources will be immeasurable. But to those who suffer from the disease, their family and caregivers, the concerns are more real and much more personal. This is the first book to explain what the Alzheimer's epidemic is. It details what is known about the disease and what is being done to find a cure. In a no-holds-barred approach, it takes the reader beyond the simplicity of newspaper articles and web-based reporting by detailing the progressive changes that occur in Alzheimer's brain. It covers what causes those changes and how biomedical researchers are directing their efforts to find the causes and a cure for this devastating disease.
The following are just some of the questions that are answered:
What are the types of Alzheimer's disease? What causes Alzheimer's disease? What are plaques and tangles? How does the disease progress? How is the latest research helping? Which pharmaceuticals offer hope? What are biomarkers and how can they help? What genes are involved in the disease? Why is finding a cure taking so long? Why does Alzheimer's exist? Was there an evolutionary advantage to plaques & tangles? What does the future hold?
The answers to these questions will not only be enlightening, they will reveal what lies on the horizon. There is good news and bad news. Knowing what they are will help us all understand what we are up against as we deal with the Alzheimer's epidemic on a personal and global level.
The Alzheimer's Epidemic is written by Danton H. O'Day, PhD, Professor Emeritus in the Department of Biology at the University of Toronto Mississauga and The Department of Cell & Systems Biology at the University of Toronto. With over 130 original research publications and several books that include original research on the brain and on Alzheimer's disease proteins, he offers an insightful, unique and critical view on the subject.
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text:
A press fit machine for assembling an electric motor which includes a hub having an upper bearing and a stator assembly having a lower bearing, includes an upper and lower press fit fixtures for holding the hub and stator respectively in a preloaded condition prior to motor assembly and for a predetermined period of time afterward. The machine press fits the two halves of the motor together while maintaining appropriate preloads on the upper and lower bearings to prevent excess looseness in the bearings or excessive stiffness. The preload ensures that the bearing will function correctly after assembly because it is maintained during a period of time that the glue joining the hub and stator assembly together sets.
1. A method of assembling an electric motor, said motor including a hub assembly portion having an upper bearing, said bearing having an inside race and an outside race, and a stator assembly portion having a rotor shaft extending through a lower bearing, said lower bearing having an inside race and an outside race, comprising the steps of:
(a) placing the hub assembly portion in a first press fixture;
(b) placing the stator assembly portion in a second press fixture;
(c) impressing a first preload force on the upper bearing of the hub assembly portion;
(d) impressing a second preload force on the lower bearing of the stator assembly portion;
(e) pressing the first and second press fixtures together thereby joining the hub assembly portion to the stator assembly portion; and
(f) maintaining third and fourth preload forces, respectively, on the upper and lower bearings for a predetermined period of time.
2. The method of claim 1 wherein at least a portion of said first and second preload forces are maintained on their respective bearings during step (e).
3. The method of claim 1 wherein the first preload force is impressed on the inner race of the upper bearing.
4. The method of claim 3 wherein the second preload force is impressed on the outer race of the lower bearing.
5. The method of claim 1 wherein the third preload force is maintained on the inner race of the upper bearing and the fourth preload force is maintained on the outer race of the lower bearing.
6. The method of claim 1 further including the step of applying an anaerobic glue to selected surfaces of the hub portion and the stator portion prior to executing step (a).
7. The method of claim 6 wherein the predetermined period of time of step (f) is selected to be sufficiently long to allow the anaerobic glue to cure.
8. A press fit machine for assembling an electric motor, said electric motor including a hub portion having an upper bearing and a stator portion having a lower bearing. Said upper bearing and said lower bearing each including an inside race and an outside race, respectively comprising:
(a) an upper fixture for holding the hub portion, said upper fixture including means for impressing a preload force on the upper bearing;
(b) a lower press fit fixture for holding the stator portion, said lower fixture including means for impressing a preload force on the lower bearing;
(c) a press cylinder for pushing the upper and lower fixtures together; and
(d) means for holding said respective upper and lower bearings in a preloaded condition for a predetermined period of
time subsequent to pushing the upper and lower fixtures together.
9. The press fit machine of claim 1 wherein the means for impressing a preload force on the upper bearing includes a preload weight which bears against an inner race of said upper bearing.
10. The press fit machine of claim 8 wherein said stator assembly comprises a central section including a shaft journalled through said lower bearing and affixed to an inner race thereof and a rotary core portion affixed to an outer race of said lower bearing, the central section of said stator assembly being held in a chuck in the lower press fit fixture whereby the weight of the rotary core impresses the preload force on said outer race of said lower bearing.
11. The press fit machine of claim 9 further including preload weight support cylinders for relieving at least a portion of said preload weight while said upper and lower press fit fixtures are pushed together with the press cylinder.
12. The press fit machine of claim 8 wherein said upper press fit fixture includes vacuum means for holding the hub portion therein prior to assembly of the electric motor.
The present invention relates to a method and apparatus for assembling electric motors and in particular includes a provision for preloading the bearings of the electric motor during assembly.
Electric motors are generally manufactured in two major parts. A rotary hub assembly houses permanent magnet members and encloses a stator assembly which includes stator coils surrounding an electromagnet. The hub assembly is joined to the stator assembly which includes a rotor shaft through upper and lower bearings. The stator assembly shaft is joined to both upper and lower bearings along the inner race of each while the hub is affixed to the outer race of both the upper and lower bearings. When the coils of the stator are energized, the hub assembly and its permanent magnet members will rotate about the shaft.
A particular problem that is encountered in the use of such bearings is that, depending upon how the motor is assembled, the coupling between the rotary hub assembly and the stator assembly can be either too loose or too tight. If the bearings are too loose there is too much play in the hub assembly, and in tightly constructed configurations the hub assembly may actually be impeded in its attempt to rotate properly. On the other hand, if the bearings are too stiff there can be too much friction between the hub assembly and the stator, and the motor will not provide the necessary torque for the particular application.
Heretofore, the bearing stiffness that resulted from the way in which the hub and stator were joined together was largely a matter of chance because there was no attempt made to control the bearing stiffness during assembly. Whether the bearings were preloaded in any way was determined by the orientation of the parts when the glue joining the parts together set. This haphazard approach to motor assembly caused many motors to fail.
The present invention provides a method and apparatus for assembling an electric motor where the motor includes a hub portion having an upper bearing comprising an inside race and an outside race and a shaft assembly portion which includes a rotor shaft extending through a lower bearing where the lower bearing also has an inside race and an outside race. A press fit machine maintains a predetermined amount of preload force on the bearings both while the two motor halves are press fitted together and for a short while afterwards while the glue sets.
According to this method, the hub assembly portion is placed in an upper press fixture and a predetermined preload weight is placed on the inner race of the upper bearing. At the same time the shaft assembly portion with anaerobic glue applied to the shaft is placed in a lower press fixture and a predetermined preload force is maintained on the inner race of the lower bearing. The shaft assembly portion and the hub assembly portion are pressed together by the press fixtures so as to join the two together. The hub portion is then disengaged from the upper press fixture while at the same time a preload weight is maintained on the inner race of the upper bearings for a predetermined period of time and the lower bearing is preloaded by its core weight. After the predetermined period of time the glue sets and the assembled motor is removed from the press fitting machine.
The press fitting machine includes a preload weight which is supported by support cylinders which are selectively actuated to allow the preload weight to rest on the inner race of the upper bearing. The lower fixture of the press fitting machine includes a spring-loaded mounting base which allows the weight of the core of the stator assembly to preload the lower bearing. The lower press fitting includes a spring-loaded chuck that raises the shaft slightly so that the core weight is suspended by the outer race of the lower bearing. The upper press fitting includes a vacuum chamber for holding the hub assembly and further includes an alignment piston for aligning the shaft of the stator assembly with the center of the hub assembly to guide the shaft through the upper bearing. A preload weight is supported on a cylinder that surrounds the alignment piston and which bears against the inner race of the upper bearing.
This apparatus insures that a preload force is maintained on the inner races of the upper and lower bearings during motor assembly. Once the motor is assembled it will be neither too loose nor too stiff as a result of the aforementioned preload being maintained during manufacture, before the glue joining the upper and lower halves of the motor has had time to set. Once the glue sets, the bearings will have the proper degree of stiffness.
FIG. 1 is a side cutaway view of two halves of an electric motor to be assembled by means of the method and apparatus described herein.
FIG. 2 is a side cutaway view of the motor assembly apparatus of the present invention.
FIG. 3 is a side cutaway view of the motor assembly of FIG. 2 with the motor halves of FIG. 1 installed therein prior to assembly.
FIG. 4 is a side cutaway view of the motor and assembly apparatus of FIG. 3 with the motor shaft alignment piston extended.
FIG. 5 is a side cutaway view of the motor assembly apparatus and motor showing the step of pressing the two halves of the motor assembly together.
FIG. 6 is a side cutaway view of the motor and motor assembly machine of FIG. 5 illustrating the preload position for the motor assembly machine.
FIG. 7 is a side cutaway view of the motor assembly machine and motor llustrating the position of the motor assembly machine when a motor is completely assembled.
FIG. 8 is a partial side cutaway view showing in detail the shaft alignment step of FIG. 4.
FIG. 9 is a partial side cutaway view illustrating in detail the press fitting step of FIG. 5.
FIG. 10 is a partial side cutaway view illustrating in detail the preload step of FIG. 6.
FIG. 11 is a partial side cutaway view illustrating the completed motor assembly shown more generally in FIG. 7.
Referring to FIG. 1, an electric motor 10, shown in two parts prior to assembly, comprises a hub assembly 12 and a stator assembly 14. The stator assembly 14 includes a central shaft 16 and stator coils 18 surrounding stator poles 19. The shaft 16 extends through the stator coils 18 to a connector 20 at which electrical connections are made which provide power and timing signals for control of the motor. The shaft assembly includes a lower bearing 22 which permits the rotation of a core portion 24 joined to an outer race 26 of the bearing 22. The inner race of the bearing 22 is joined to the shaft 16.
The hub assembly 12 includes permanent magnet members 30 and a lower flanged portion 32 which will join with the rotary core 24 once the hub assembly 12 is press fitted to the stator assembly 14. The hub assembly includes an essentially cylindrical housing 34 which is joined to a bearing 36 (hereinafter referred to as "the upper bearing") at its outside race 38. The inner race 40 of the upper bearing 36 is intended to be joined to the rotor shaft 16 by glue or the like as will be described below.
Referring to FIG. 2, a press fit machine 42 includes an upper fixture 44 and a lower fixture 46. The upper fixture 44 includes a vacuum chamber 48 and a source of negative pressure 50 designed to hold the hub assembly 12 in the upper fixture 44 prior to assembly. The upper fixture 44 also includes a preload weight 52 and preload weight support cylinders 54a and 54b. An alignment piston 56 is controlled by an alignment cylinder 58.
The lower press fixture 46 includes an upper platform 60 which supports a stationary base 62. The stationary base 62 is rigid and does not move with respect to the platform 60. A cylindrical well inside the base 62 holds a spring-loaded chuck 64. The platform 60 rests on a frame 66 which houses an air intake line 68 and an air outlet line 70 for a press cylinder 72. In FIG. 2 the press cylinder 72 is shown in its retracted position, and the direction of air flow is shown by the arrows at the inlet line 68 and the outlet line 70. A second frame 74 houses air inlet and outlet lines 76 and 78, respectively, of a preload cylinder 80. In FIG. 2, the preload cylinder 80 is in the extended position. The arrows show the direction of air flow.
Referring now to FIG. 3, the first step in assembling the motor 10 is to load the hub assembly 12 into the vacuum chamber 48 of the upper press fixture 44. The vacuum line 50 is then vacuated which holds the hub assembly 12 in such a way that the preload weight 52 is pushed up by the hub assembly. This is shown in more detail in FIG. 8. The preload weight 52 is supported by a cylinder 82 which encloses the alignment piston 56 and which has a foot 84 of reduced radius that bears directly against the top of the inner race 40 of the upper bearing 36. The preload weight 52 weighs about three pounds, but the preload weight cylinders 54a and 54b relieve about two pounds of this weight with the result that a one-pound net force rests on the inner race 40. This preloads the bearing 36 while the two motor halves are being assembled, and prevents the shaft 16 from knocking the bearing 36 out of alignment. Also, the preload weight cylinders 54a,54b are designed to relieve some of the magnetic attraction force otherwise occasioned by the proximity of the permanent magnets 30 to the stator coils 18 as the motor halves are brought together. The outer race 38 is pulled up with the rest of the hub assembly 12 by the vacuum force 50 to bear against an upper O-ring 86 and a lower O-ring 81.
The stator assembly 14 rests partially on the stationary support 62 and partially on the spring-loaded chuck 64. A central section 15, which includes the shaft 16 and the connector 20, also includes a flanged portion 21 which supports the inner race 28 of the bearing 22. As FIG. 8 shows, the flanged portion 21 is relieved radially outwardly of the inner race 28 so that it does no bear against the outer race of the bearing 26. The flanged portion 21 has a foot 23 that rests directly on top of the spring-loaded chuck 64. The rotary core portion 24 also has a foot 25 and this foot nearly rests on top of the stationary support 62, but because the chuck 64 is slightly raised with respect to the support 62, the weight of the core 24 bears down on the outer race 26 of the bearing 22. The rotary core 24 is connected to the outer race 26 and it rotates with respect to the central section 15.
FIG. 4 shows an expanded view of the apparatus shown in FIG. 8. In FIG. 4 the alignment piston 56 extends to engage the center of the shaft 16. This will guide the shaft through the upper bearing 36. At this time preload cylinder 80 is extended but the press cylinder 72 remains retracted.
Referring now to FIGS. 5 and 9, once the alignment cylinder 58 has caused the alignment piston 56 to engage the shaft 16, the two halves of the motor 10 may be press fitted together. In order to do this, the press cylinder 72 is extended. This cylinder will push the rotor shaft assembly 14 into the hub assembly 12 until the flanged portion 32 fully engages the stationary support 62. Once this occurs there will be zero pressure on the outlet side 70 of the cylinder 72 and the cylinder will halt.
Once the two halves of the motor are press fitted together, glue that has been placed on the outside of the rotor shaft 16 and on the outside of the rotary support 24 will begin to harden. The glue is applied prior to placing the motor 20 in the press fit apparatus. This is an anaerobic glue that will begin to set only when the surfaces to be joined are press fitted together. It is important that the upper and lower bearings remain preloaded with a predetermined amount of force while the hardening of the glue takes place. In order to accomplish this, the vacuum source 50 is turned off and the preload cylinder 80 retracts. At the same time this occurs, the preload weight cylinders 54a and 54b retract allowing the entire amount of the preload weight 52 to be borne by the inner race 40 of the upper bearing 36. With the preload cylinder 80 retracted, the weight of the hub assembly which is affixed to the core 24 weights the outer race 26 of the lower bearing 22 because the spring-loaded chuck 64 lifts the central section 15 so that the foot of the core 24 is slightly above the stationary support 62. The bearings remain in this preloaded condition for about 15 seconds while the glue sets. Finally, as shown in FIGS. 11 and 7, the press cylinder 72 may be retracted allowing the motor to be removed. This resets all cylinders so that the machine is ready for the next motor.
The terms and expressions which have been employed in the foregoing specification are used therein as terms of description and not of limitation, and there is no intention, in the use of such terms and expressions, of excluding equivalents of the features shown and described or portions thereof, it being recognized that the scope of the invention is defined and limited only by the claims which follow.
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Don't get me wrong I know the movie is excellent. The problem,is .. I cannot view this movie with my DVD player due to region codes. I ordered it from Amazon. Read morePublished 1 month ago by Karen
Old movie but a great movie everyone should see it at least oncePublished 7 months ago by Vicki Rigsby
Fine film sent wrong region, part of an order the rest of which was OK.Published 9 months ago by Walter A. Babiak
I didn't realize that this DVD cannot be played in Canada, only in Europe! It should be stated explicitly right on the top that it is only for Region 2.Published 13 months ago by Michael Soltys
For any lovers of World War II history this is a wonderful older film. Donald Sunderland and Kate Nelligan are excellent in it, the story keeps you in its grip so curl up at home... Read morePublished 19 months ago by Christine Emmett
Great entertainment, however, odd that Donald Sutherlands hat remains glued to his head all through the movie despite rain and windPublished 19 months ago by James P Jones
It proves that when you are in the deprived of tenderness sometimes we do things that we regret afterwards. but I think that he did love her and he did let her kill him.Published 23 months ago by estelle cazelais
MARVELOUS, keeps you rivitrd to the story. One of my favorite Follrt works. ZThe book is sensational. I edon't have a DVDPublished on April 15 2004 by "2twocool"


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31 year old woman | Donora, PA, USA | Seeking men 25-36 in Pittsburgh, Pennsylvania, United States
Happy and Optimistic
Where do I start? I would say I am confident, independent and very hard working. I am driven and passionate about helping others. I like to keep active. I am caring and compassionate. If my family needs anything, I am always there to help them in an instant. I enjoy the simple things in life and enjoy taking it all in. I am very passionate about influencing the lives of my students in a positive way. I have a huge heart and wear it on my sleeve. I am always on the go and getting into some type of fun. I have a very strong faith in God and I live my life to do his will. My ideal match would be someone who puts God first, is trustworthy, loving, energetic and into helping others. Oh and you have to be able to make me laugh, either with me or laugh at me. :) If you want to know more, email me if your curious:)
Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing sports , Religion/Spiritual , Travel/Sightseeing , Volunteering , Watching sports
Basketball, Billiards / Pool, Dancing, Golf, Soccer, Walking / Hiking, Weights / Machines
I exercise 3-4 times per week.
I like Dogs
I like going to see concerts of local bands, sporting events, going out and eating at new places. Panama, Ft Lauderdale Florida,
I am really into art and culture, sunsets, my dog Emma, spending time with my family, laughing, going to church, worship music, teaching art, being a leader, coaching soccer and track.
concerts, music, salsa dancing, art, play my guitar, coach soccer, work with the youth at my church, missionary work. Spend time with my family, plan trips
Crazy Love! This is a great book and a must read.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'7" (170cms)
|5'7" (170cms) to 6'5" (195cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned
|Blue, Brown, Green, Hazel
|Dark blonde
|No preference
|No Way
|No Way
|Social Drinker
|Never, Social Drinker
|Education / Teacher / Professor
|No preference
I teach art and I love my job, it is a blessing to be able to get students excited about expressing themselves.
|I'll tell you later
|No preference
|Never Married
|No preference
|Have kids:
|No preference
|Wants kids:
|Definitely, Someday
|White / Caucasian
|No preference
|Christian / Other
|Christian / Catholic, Christian / Protestant, Christian / Other
|Graduate degree
|No preference


text:
Did you know? The heat in the upper six miles of the earth's crust contains 50,000 times much as energy as found in all the world's oil and gas reserves combined. Despite this abundance, only 10,500 megawatts of geothermal generating capacity have been harnessed worldwide. For more information view the text and data in Chapter 5 of Plan B 4.0: Mobilizing to Save Civilization.
Janet Larsen on National Journal's Blog on Energy & Environment - "A Paler Shade of Green?"
March 22, 2010
Janet Larsen, Director of Research, contributes to the National Journal's Blog on Energy and Environment, titled "A Paler Shade of Green?" Her response - "Americans Do Care About Climate." Posted March 22, 2010.


text:
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Town Square
Hospital district candidates finalized
Original post made on Aug 17, 2012
Read the full story here Web Link posted Friday, August 17, 2012, 10:45 AM
Comments (2)
a resident of Cuesta Park
on Aug 17, 2012 at 2:26 pm
Let us bring new blood! We can do better.
a resident of Whisman Station
on Aug 21, 2012 at 1:48 pm
" Both incumbents said that their experience on the board makes them the best choices for this election" Uhhh really? Running out the talent which cost the hospital loads of cash and floundering through your tenure there means your best fit for the job? Lets bring in some new blood!
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text:
Page 1
QSAR Models for Predicting Cathepsin B Inhibition by Small
Continuous and Binary QSAR Models to Classify Cathepsin B Inhibition Activities of Small
Zhigang Zhou, Yanli Wang, and Stephen H. Bryant*
National Center for Biotechnology Information, National Library of Medicine, National Institutes of
Health Bethesda, MD, 20894, USA
Cathepsin B is a potential target for the development of drugs to treat several important human
diseases. A number of inhibitors targeting this protein have been developed in the past several years.
Recently, a group of small molecules were identified to have inhibitory activity against cathepsin B
through high throughput screening (HTS) tests. In this study, traditional continuous and binary QSAR
models were built to classify the biological activities of previously identified compounds and to
distinguish active compounds from inactive compounds for drug development based on the
calculated molecular and physicochemical properties. Strong correlations were obtained for the
continuous QSAR models with regression correlation coefficients (r2) and cross-validated
correlation coefficients (q2) of 0.77 and 0.61 for all compounds, and 0.82 and 0.68 for the compound
set excluding 3 outliers, respectively. The models were further validated through the leave-one-out
(LOO) method and the training-test set method. The binary models demonstrated a strong level of
predictability in distinguishing the active compounds from inactive compounds with accuracies of
0.89 and 0.94 for active and inactive compounds, respectively, in non-cross-validated models. Similar
results were obtained for the cross-validated models. Collectively, these results demonstrate the
models' ability to discriminate between active and inactive compounds, suggesting that the models
may be used to pre-screen compounds to facilitate compound optimization and to design novel
inhibitors for drug development.
Binary QSAR; regression; partial least squares; docking; cathepsin B protein; screening; PubChem
As members of the papain superfamily,1 cathepsins are involved in many biological processes
related to human diseases and disorders.1–4 Previously identified cathepsins include cathepsin
B, D, H, K, L, and S. Several of these proteins have been selected as biological targets to
develop therapeutic treatments, and a number of inhibitors have been identified and developed
for many of these enzymes. Cathepsin B inhibitors are highly sought after chemical agents
since many diseases, such as neurodegenerative disorder, cardiovascular disease, cancer,
*Corresponding author. Tel: (301)-435–7792; Fax: (301)-480–9241; firstname.lastname@example.com, firstname.lastname@example.com. NCBI/
NIH, Bethesda, MD 20894.
NIH Public Access
Author Manuscript
J Mol Graph Model. Author manuscript; available in PMC 2011 June 1.
Published in final edited form as:
J Mol Graph Model. 2010 June ; 28(8): 714–727. doi:10.1016/j.jmgm.2010.01.009.
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inflammation, rheumatoid arthritis, and Alzheimer's disease5–12, have been connected with
unusual levels or abnormal function of cathepsin B. As an ubiquitous lysosomal cysteine
proteases, cathepsin B has been found to be responsible for intracellular as well as extracellular
proteolysis in mammalian cells and can facilitate cell migration by dissolving the extracellular
barriers, which result in tumor metastasis and angiogenesis.13–15 The biological activity and
function of cathepsin B is also important during viral infection and replication for several
viruses, such as Ebola, SARS (Severe Acute Respiratory Syndrome) in human cells.16, 17 Due
to its important biological functions, which are directly related to several important human
diseases, cathepsin B has been chosen as a drug development target in many efforts.
A number of compounds have been found to inhibit cathepsin B activity, and some of these
compounds have been tested and are effective in animal experiments.5–12, 18–20 Most of these
cathepsin inhibitors disable the biological activity of cathepsin B through forming irreversible
covalent chemical bond in the catalytic site of the enzyme. These irreversible inhibitors include
dipeptidyl nitriles21, vinyl sulfones, expoxysuccinates, acyloxymethyl ketones, fluoromethyl
ketones, hydrazides, and bis-α-amidoketones.22 Structural studies have provided detailed
insights into the biological mechanisms of these inhibitors. Inhibitors bind to the catalytic active
site of cathepsin B, and form an irreversible covalent bond with the protein in the active site.
21, 23 Meanwhile, computational studies, such as docking and virtual screening, were also used
to explore the binding and inhibition mechanism of these inhibitors.24–26 These computational
approaches have proved efficient and essential for optimizing and designing chemical agents
with improved biological activities.27–29
In an effort to identify chemical probes through high throughput screening technology (HTS),
a number of chemicals have been found to be active against cathepsin B in the screening
campaign for inhibitor identification, with the NIH Molecular Libraries Program (MLP). The
screening results were deposited into the PubChem (http://pubchem.ncbi.nlm.nih.gov), a
database for molecular structures and associated biological activities which is available to
general public. The database contains the 2D structures and the biological activity (IC50)
derived from dose-response HTS experiments for the active compounds tested.
In a previous study,30, 31 docking simulation was used to model the binding structures of the
active compounds identified by the high throughput screening (HTS) tests to the binding site
of the protein. A relative binding affinity was calculated for each compound studied based on
the respective modeled bound structure using the linear response molecular mechanics Poisson
Boltzmann-surface area method (LR-MM-PBSA). Strong correlations between the calculated
binding affinities and experimental biological activities were obtained.30, 31 Three-dimension
(3D) Comparative Molecular Field Analysis (CoMFA) quantitative structure-activity
relationships (QSAR) models were also established based on the multi-conformation method
with high correlation coefficients for these active compounds (to be published). Given the
importance of the enzyme in disease treatment and the broad research interest to screen and
identify potent inhibitors, efforts have been taken further to build the QSAR models to correlate
the molecular and physicochemical properties with the biological activities of the compounds
tested in the Cathepsin B inhibition screening experiments. Efforts were also undertaken to
build statistical models to classify inhibition activities against Cathepsin B for specific
compounds. This work reports the results of the continuous (continuous in bioactivity space)
and binary (two discrete bioactivity status, e.g. 'active' vs 'inactive') QSAR models in order
to obtain insight into the relationship of chemical structure and physicochemical properties/
biological activity. Additionally, the results of this work may provide means to pre-screen
compounds to facilitate in silico design of de novo cathepsin B inhibitors and the development
of drugs for the treatment of varies human diseases using some other molecular targets.
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Materials and Methods
Data Set and Molecule Preparation
The 3D chemical structures of all small molecule compounds were first converted from the 2D
molecular structures obtained from the PubChem database (PubChem bioAssay accession: 820
and 523),32 which were subsequently subjected to energy minimization calculation until the
root mean square deviation (RMSD) of potential energy was smaller than 0.001, using the
Optimized Potentials for Liquid Simulations (OPLS) force field33–36 by the Molecular
Operating Environment (MOE) program (Version 2007.09, developed by Chemical
Computing Group, Montreal, Canada). In Bioassay AID (Pubchem bioassay accession) 820,
75 compounds were tested by a dose response confirmatory screening experiment, whereas 37
compounds were confirmed to have inhibitory activity, 35 compounds were confirmed to have
no inhibitory activity, and the bioactivity outcome for the remaining 3 compounds were
reported as "inconclusive". By further examining these active compounds using different
experimental protocol, assay depositors suggested that some of them were likely artifacts.
Further investigation using several independent bioassay tests (different biological
experiments), which may be affected by similar causes of artifact, suggested that five
compounds bear greater chance as being false positives, and they were removed from the
current analysis. So, 32 active (37–5) and 35 inactive compounds from bioassay 820 were
included in the work. Bioassay 523 employed a similar experimental protocol to the Bioassay
820, where 27 compounds were tested, 10 compounds were confirmed having inhibitory
activity, 16 compounds were confirmed having no inhibitory activity, and one (1) compound
was reported as "inconclusive". Four out of the 10 active compounds are unique structures and
were added to the active compound list. Total 36 active compounds (32 from bioassay 820 and
4 from bioassay 523) and 51 inactive compounds (35 from bioassay 820 and 16 from bioassay
523) were used in the modeling. The average IC50 reported in the bioassay depositions was
used for the bioactivity of the active compounds. The PubChem compound accession (CID),
molecular formula, and biological activity (IC50) for the 86 compounds are listed in Table 1
(one active compound was not included in QSAR modeling as no 3D conformer was obtained
in docking simulation). Molecular structure and other information can be obtained from
PubChem website based on CIDs (http://pubchem.ncbi.nlm.nih.gov) and the bioassay protocol
information can be obtained from PubChem website by BioAssay ID (AID) 820 and 523
(http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=820 and
http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=523).32 The compounds tested in the
confirmatory assays were cherry picked based on the screening results for over 60,000
compounds in a single dose HTS assay for potential cathepsin B inhibition activity (PubChem
AID:453) by measuring the release of the fluorophore aminomethyl coumarin (AMC) from
the hydrolysis of an AMC-labeled dipeptide, The large number of inactive compounds from
the primary HTS assay were not included in the model since the statistical methods typically
do not perform well on unbalanced data sets. Therefore claiming all compounds as inactive
will yield an accuracy of 99.94% as pointed out by Weis and coworkers.37
The three dimensional structure coordinate of cathepsin protein with bound Dipeptidyl Nitrile
(DPN) was obtained from Protein Databank (PDB code: 1GMY21). The PDB file for the
crystallographic structure complex of cathepsin B contains three chains A, B and C. The first
two chains form a dimer and were used in docking simulation (Figure 1). Hydrogen atoms and
partial charges were added to the protein and then short steps of minimization were performed
to relax the newly-added hydrogen atoms and the potential steric contacts in the original PDB
coordinates. The minimizations were performed using an OPLS force field following the
standard protocol of the Glide program (version 8 in FirstDiscovery suite).38, 39 The minimized
protein structure was then used to generate a docking grid which was used to docked all active
compounds into the DPN binding site. A docking box (exterior box) of 16 × 18 × 22 Å for the
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placement of all ligand atoms and a restraining box (interior box) of 8 × 10 × 14 Å for the
placement of ligand geometric center were used to generate the docking grid. The boxes were
centered at the geometric center of DPN ligand. Default values were used for all other settings
within Glide (version 8).
Conformation Determination and Molecule Alignment
All active compounds were flexibly docked into the active site of the cathepsin protein based
on the generated docking grid. All docking simulations were carried out using Glide program.
Details of the docking simulation can be obtained from previously reported work.30, 31, 40
Docking simulation was used to determine the "active" conformation of each compound
according to the structural and physicochemical properties of the binding site. The 3D
conformation for each inactive compound was modeled by flexibly aligning it to the 3D
conformer of DPN, the ligand in the crystal complex. The alignment was carried out based on
molecular shape (volume) and pharmacophore elements using the flexible alignment module
implemented in MOE, Default parameters were used for the flexible alignment. The
conformation for each active compound was also obtained using the same alignment for the
comparison with the conformation obtained from docking simulations in QSAR modeling.
Statistical Analysis
Partial Least-Squares analysis (PLS) method was used to conduct statistical analysis and to
derive a continuous QSAR model based on the descriptors calculated for each inhibitor. The
PLS method has been proved to be a priority method for such statistical analysis especially in
the case where the number of descriptors is large. All PLS calculations were carried out with
the module implemented in MOE. The log10IC50 value was used as a dependent variable and
the calculated molecular and physicochemical properties were used as independent variables
for the analysis. Over 50 descriptors were calculated and preliminary factor analysis was
conducted to obtain the optimum correlation between each individual descriptor and the
biological activity (logIC50). The nine descriptors listed in Table 2 were selected and used to
build QSAR models. An optimal number of components (9 components for continuous models
and 8 for binary models) were used to build final models.
Model validation was carried out by the Leave-one-out (LOO) cross-validation procedure and
training-test set approach in which the compounds were split into training sets for model
building and test sets for which activities were predicted by the built model. Both continuous
and binary models were validated by LOO and three (3) training-test experiments in which
nine compounds were randomly selected as test compounds and all other compounds were
used as training set for QSAR model building. The LOO technique provides a good way to
quantitatively evaluate the predictive ability and robustness of a model by predicting each
compound s activity using a QSAR model built based on information of the remaining
compounds, which avoids the effect of a compound on its own activity prediction. This
approach tries to eliminate the over-fitting problem normally existing in conventional
regression method which includes all compounds in model construction. A cross-validated
correlation coefficient (q2) was used to measure the predictability of a model and the
conventional correlation coefficient (r2) was used to measure the quality of a model.
Results and Discussion
Conformation determination and alignment construction
In order to calculate the physicochemical and molecular property-based descriptors to build
QSAR models, 3D confirmation for each studied compound was needed. The 3D structures of
these compounds were first converted from their 2D structures. As stated in the method section,
totally 36 active compounds and 51 inactive compounds with unique structures were obtained
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from two confirmatory bioassay data entries (PubChem AID 820 and 523). Docking
simulations and molecular alignment methods were applied to obtain active 3D confirmers for
the 36 active compounds. In the docking simulations, the active compounds were docked into
the active site of cathepsin B using the same methodology and confirmation determination
procedure as described previously.30 Reliable docked poses were obtained for all but one
compound. Detail results and discussion on conformer selection and comparison for most
compounds can be found in previous report.30 As a result, the 35 compounds with docking
results were included in the QSAR modeling. The docked cluster of the active compounds is
depicted in Figure 2. It is seen that all these compounds were docked in the binding site with
comparable binding conformers and roughly the similar locations.
In the molecular alignment, all 86 (active and inactive) compounds were superposed onto DPN
using flexible molecular alignment method. The best fitted conformation of each compound
was selected. The fitting was scored based on molecular shape (occupied volume) and
pharmacophore matching which includes hydrogen donor, hydrogen acceptor, hydrophobic
atoms, polar hydrogen atoms, and aromaticity of the two molecules. The 3D conformation for
each compound was selected based on the best fit from MOE. Two separate sets of molecular
structures were prepared, one based on docked structures for active compounds and molecular
alignment for inactive compounds and the other based on the molecular alignment for all
compounds. The two sets of 3D structures were used to build QSAR models for comparison
and they yielded the very similar results. The information, including PubChem compound
accession, e.g. CID, molecular formula, SMILES (Simplified Molecular Input Line Entry
Specification) string, molecular weight (MW), and the activity (IC50), as obtained from
PubChem BioAssay database (AID: 820 and 523) of all 86 compounds used in the work are
listed in Table 1. To build a binary QSAR model, the activities of the active and the inactive
compounds were assigned as of 1 and 0, respectively.
Descriptor calculation
Over 250 descriptors are available with MOE QSAR module. Initial selection for the
descriptors was attempted empirically based on the nature of the descriptors, the features of
the studied molecular set, and the problem studied. Those which are not relevant to the
modeling, such as the total energy, heat of formation, the numbers of bromine, boron, fluorine,
or phosphorus atoms, were eliminated from further consideration in the work. Over 50
descriptors of physicochemical molecular properties were selected and calculated for all
studied compounds based on the constructed 3D conformations using the methods
implemented in MOE (version 2007.09). Factor analyses were performed to examine the
correlation between each individual descriptor and the biological activity (logIC50) of these
compounds. The nine descriptors that demonstrated an apparent correlation with the observed
biological activity were chosen to build QSAR models, which are listed in Table 2. Among
these descriptors, Nacc+don is the sum of the counts of hydrogen acceptor and donor. Apol, MR,
and Dipole are the sum of atomic polarizabilities,41 molar refractivity, and the dipole moment
of a molecule calculated from the partial charges of the molecule, respectively. SA and
SApol are the water accessible surface areas (WASA) of whole molecule and the hydrophilic
part of WASA calculated using a radius of 1.4 Å for the probe, respectively. Vol, Esol, and
logP(o/w) are the molecular volume, the empirical solvation energy calculated based on OPLS
force field, and the log value of octanol/water partition coefficient of a compound, respectively.
Most of these descriptors are related to the molecular solvation properties to some degree.
Calculation of molecular solvation or partition of a compound between hydrophobic and
hydrophilic compartments still remains challenging. Combination of various computational
methods would be a better choice to estimate the chemical s partition property which is well
regarded to have direct and large effect on its biological activities.
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text:
Bugzilla – Bug 15432
3D syntax for transform-origin conflicts with background-position-like syntax, causing ambiguity
Last modified: 2012-03-07 21:58:29 UTC
No browser appears to implement the three- or four-value versions of transform-origin per spec. IE9 and Opera Next 12.00 alpha don't seem to support three or more values at all. Firefox 12.0a1 and Chrome 17 dev seem to support three arguments (not documented on MDN: https://developer.mozilla.org/en/CSS/transform-origin), but not per spec. For instance, "-(moz|webkit)-transform-origin: left bottom -1px" works (is parsed), but "0% 100% -1px" does too, which the spec doesn't allow; and "bottom -1px left" doesn't work, although the spec says it should.
The easiest way forward seems like just dropping the three- and four-value variants of transform-origin. Aren't they redundant with calc() anyway? You can do things like "transform-origin: calc(0% - 10px) calc(100% + 5px)" instead of "transform-origin: left -10px bottom 5px".
The 2D version of transform-origin is intended to have exactly the same behavior as background-position. The 3D version adds a final option value which is the z-offset.
Do browsers plan to try implementing transform-origin as the spec says, though? AFAICT, none currently do.
I think WebKit's version matches background-position.
From black-box testing in Chrome 17 dev, background-position doesn't accept more than two arguments. Setting document.head.style.backgroundPosition = "left bottom 1px" has no effect.
Also, I just figured out that WebKit accepts three arguments to -webkit-transform-origin, but treats them completely differently from the spec. Setting document.head.style.webkitTransformOrigin = "left bottom 1px" adds the attribute style="-webkit-transform-origin-x: 0%; -webkit-transform-origin-y: 100%; -webkit-transform-origin-z: 1px; ". So the third argument is interpreted as z-axis, totally different from <http://dev.w3.org/csswg/css3-transforms/#transform-origin-property>. I suspect Gecko does the same, because it doesn't accept percentages for the third argument. They seem to implement it per <http://dev.w3.org/csswg/css3-3d-transforms/#transform-origin-property>.
So it looks like the 2D three-argument variant of transform-origin conflicts with the 3D variant. Browsers appear to implement the 3D variant or nothing, so as far as I can see it, the 2D spec should still not define a three-argument variant for transform-origin. Am I missing something?
The transforms spec matches the backgrounds & border spec:
Okay, I feel like we're talking past each other. Let me say what I mean in more detail:
The 2D and 3D transform specs conflict: <http://dev.w3.org/csswg/css3-transforms/#transform-origin-property> vs. <http://dev.w3.org/csswg/css3-3d-transforms/#transform-origin-property>. We can't give 2D transform-origin the same syntax as CSS 3's background-position if 3D transform-origin gives a different meaning to the same value. Per the current 2D transform spec,
transform-origin: left bottom 10px;
means the transform origin is ten pixels above the bottom-left corner of the element along the *Y*-axis. Per the current 3D transform spec, the exact same property declaration means that the transform origin is ten pixels above the bottom-left corner of the element along the *Z*-axis. They can't both be right. Gecko and WebKit both implement the 3D spec, not the 2D, as demonstrated by the following test-case:
data:text/html,<!doctype html>

Per the 2D transform spec, this should rotate the red box 45 degrees around the center of its left edge, same as this:
data:text/html,<!doctype html>

Per the 3D transform spec, it should rotate it 45 degrees around its bottom left corner, same as this:
data:text/html,<!doctype html>

Firefox 12.0a1 and Chrome 17 dev both do the latter. I suggest the 2D spec change to not conflict with the 3D spec here, since browsers follow the 3D spec. The easiest way to do this is to change the 2D spec to only accept two values.
This is the same as bug 14647.
*** Bug 14647 has been marked as a duplicate of this bug. ***
*** Bug 15631 has been marked as a duplicate of this bug. ***
21 Feb Informal editors meeting: resolution was to send to public-fx with the alternatives and suggestion:
- transform origin matches background-position up to a / character, after that is Z
- new property transform-origin-z which separates the Z value
- leave the properties inconsistent and define syntax only for transform origin Z
Discussion: http://lists.w3.org/Archives/Public/public-fx/2012JanMar/0112.html
(In reply to comment #11)
> Discussion: http://lists.w3.org/Archives/Public/public-fx/2012JanMar/0112.html
The CSS WG decided to go the way current implementation support "transform-origin", means just one argument per dimension. That means transform-origin will have 1 to 3 arguments. First two are translation-values, the last one length. The last two arguments will be optional each.
(In reply to comment #12)
> (In reply to comment #11)
> > Discussion: http://lists.w3.org/Archives/Public/public-fx/2012JanMar/0112.html
> The CSS WG decided to go the way current implementation support
> "transform-origin", means just one argument per dimension. That means
> transform-origin will have 1 to 3 arguments. First two are translation-values,
> the last one length. The last two arguments will be optional each.
I've implemented this decision: http://dvcs.w3.org/hg/csswg/rev/16db95fda02f


text:
Walid Phares
May 26, 2015 3:21 pm
The Unknown and suppressed story of the last days of South Lebanon's "belt"
by Walid A Phares
Dec 15, 2014 8:40 pm
Sydney's Lesson: The Mutant Jihadists are coming
by Walid A Phares
Dec 1, 2014 4:20 am
Both Pope and Patriarch now worried about Middle East Christians; too little, too late?
by Walid A Phares
Jul 1, 2014 3:00 am
The Free Iran we can work with
by Walid A Phares
May 27, 2014 4:22 pm
The Handshake in Paris that Could Undermine both Syria and Iran
by Walid A Phares
May 6, 2014 2:48 am
Washington's strategic mistake in Iraq: Abandoning Iran's exiled opposition
by Walid A Phares
Apr 25, 2014 1:40 pm
The Khomeinist Dome: Iran's Larger Nuclear Strategy
by Walid A Phares
Apr 13, 2014 1:40 am
Media elite's extreme fascination with the Jihadist individuals' personalities hurts the victims of the Boston bombing
by Walid A Phares
Apr 10, 2014 10:52 pm
Arab moderates' 'Iran problem' is in Washington
by Walid A Phares
Mar 6, 2014 1:06 am
by Walid A Phares
Mar 1, 2014 3:24 am
Iran' Nuclear Deal: Washington's greatest mistake
by Walid A Phares
Feb 23, 2014 12:13 am
The Strategic Consequences of an East-West Ukrainian Split
by Walid A Phares
Feb 11, 2014 8:58 pm
In Africa, France Must Lead or Fall
by Walid A Phares
Jan 27, 2014 7:28 pm
A Miracle on the Nile
by Walid A Phares
Jan 27, 2014 7:15 pm
A King for the oppressed—Not a King for the oppressors
by Walid A Phares
Aug 14, 2013 6:53 pm
Muslim Brotherhood's "Urban Jihad" Wages Terror War on Egypt's Secular Revolution
by Walid A Phares
Jul 8, 2013 8:06 pm
The Nile of Democracy will Flood Egypt's Jihadists
by Walid A Phares
Jun 17, 2013 3:59 am
The US Strategies for Syria
by Walid A Phares
May 23, 2013 1:38 pm
Woolwich's Jihadi butchers: their non-spontaneous words matter
by Walid A Phares
May 20, 2013 10:42 pm
How the State Department Gets the Niqab Wrong
by Walid A Phares
- Thomas Piketty accuses Germany of forgetting history as it lectures Greece
- Greek 'No' May Have Its Roots in Heroic Myths and Real Resistance
- 150 years later, schools are still a battlefield for interpreting Civil War
- Where are America's memorials to pain of slavery, black resistance?
- Richmond split over Confederate history
- Historian: "I don't want my students to simply choose sides in a polemic between heritage and hate"
- Harvard's Nancy Cott says the Chief Justice in the gay marriage case has a stilted idea of the history of marriage
- Did a historian who said he's a victim of McCarthyism get the story wrong?
- Stephanie Coontz's work on the history of marriage cited by the Supreme Court.
- How Does It Feel To Have One's Work as a Historian Cited by the Supreme Court? Cool. Very Cool. Thank You Very Much.


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text:
I am new to iphone development with objective C and XCode 4.2. Right now I successfully instantiated a UITableViewController and it can traverse a multi level json data tree. however, I'm having trouble establish the UI for the leaf page. Let me show you a snippet of code so far:
- (void)tableView:(UITableView *)tableView didSelectRowAtIndexPath:(NSIndexPath *)indexPath
[tableView deselectRowAtIndexPath:indexPath animated:YES];
int row = [indexPath row];
NSString * currentrow = [NSString stringWithFormat:@"%d.",row];
NSDictionary * item = [dataArray objectForKey:currentrow];
NSDictionary * children = [item objectForKey:@"children"];
if(children != nil)
uinavTableViewController *childView = [[uinavTableViewController alloc] init];
childView.dataArray = children;
[self.navigationController pushViewController:childView animated:YES];
uinavMenuItem * childView = [[uinavMenuItem alloc] init];
//uinavSecondViewController * childView = [[uinavSecondViewController alloc] init];
[self.navigationController pushViewController:childView animated:YES];
So the first part of the if statement will check if there are children nodes, if so create another uinavTableViewController. This part works perfectly.
The else statement creates a leaf page using the uinavMenuItem. When I run this in the simulator, the leaf page is just a black screen. I looked in my NSLog and can confirm that the uinavMenuItem viewDidLoad did get fired. So the controller code is working fine, but i just don't know how to link up to the view I've drawn in the storyboard.
What am I doing wrong that prevents the uinavMenuItem from displaying what I've drawn in the storyboarD?


text:
Sunset Cocktails and (free) Live Jazz
- Music
- 420 Park Avenue South, New York, NY, 10021
Emmanuel Baptist Church Jazz Vespers Featuring The Elan Trotman Group
Jazz Vespers at Emmanuel Baptist Church
Sunday, June 29, 2014 from 3:00 PM to 5:00 PM (EDT)
Join us as we celebrate Caribbean-American Heritage Month, featuring The Elan Trotman Group, comprised of Elan Trotman (Saxophone), Kareem Thompson (Steel Pan), Anthony Steele (Drums), Mark Copeland (Keyboards), Zack Rochester (Bass), and Tyrone Chase (Guitar).
There's nothing like the sound of a steel pan to transport you to a place in your mind where you can envision sandy beaches, beautiful clear waters, and sumptuous blue skies. Be prepared to experience this feeling, while grooving to melodic, Caribbean-inspired Jazz at the next Emmanuel Baptist Church Jazz Vespers honoring Caribbean-American Heritage Month, taking place on Sunday, June 29th from 3pm-5pm, featuring The Elan Trotman Group.
The Elan Trotman Group is comprised of 5 Berklee College of Music alumni, and showcases Trotman's compositions in a unique Caribbean Jazz setting, featuring sax and steel drums, along with a 4-piece rhythm section. Saxophonist Elan Trotman is an award-winning recording artist from the island of Barbados. Be sure to invite your friends and family!
With a wonderfully eclectic mix of jazz musicians, mind-blowing acoustics, and spirit-filled music that will touch your soul, our Jazz Vespers service is not to be missed.
To find out more about Emmanuel Baptist Church Jazz Vespers, visit http://ebcconnects.com/jazzvespers/
Join millions of people on Eventbrite.
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text:
Very seldom that history books would mention this but yes, Aguinaldo wrote a letter to the pope. The copy that survived to this day was actually just a draft and so we do not know if ever it had reached Rome. 1,250 more words
Tags » Philippine Revolution
347 more words
Debunk the claim of Leftists that their worldview is scientific. Remind them that they don't have a monopoly of truth and that grand narratives in the social sciences are no longer fashionable.
Philippine Independence
In 1896, the Philippine Revolution began. In December 1897, the Spanish government and the revolutionaries signed a truce, thePact Biak na Bato, requiring that the Spanish pay the revolutionaries 800,000 pesos and that Emilio Aquinaldo and other leaders go into exile in Hong Kong. 332 more words
VIRAL: Testimonial video of prisoners of war held by communist rebels
I wrote this roundup for the Philippine Online Chronicles.
A testimonial video of Philippine state security forces held as Prisoners of Wars (POWs) by the Communist Party-led New People's Army (NPA) has turned viral online with over 271,113 views, 7,498 likes, 5,928 shares, and 1,399 comments on… 547 more words
Mga Katanungan Ukol sa mga Hindi Makabayaning Gawain ni Emilio Auginaldo
May isang artikulo sa internet na naglista ng ilang "pagkakamali" daw ni Emilio Aguinaldo, mga dahilan kung bakit ayaw ng ilang Pilipino sa kanya. Bagaman naniniwala din ako sa pagiging tao ni Aguinaldo, naniniwala din ako na ang artikulo ay naging masyadong payak ang paglalahad sa mga pangyayari at hindi naging patas sa pagsusuri sa kasaysayan ukol kay Aguinaldo. 481 more words
Celebrating Rizal Day in the Philippines
Today is Rizal Day, a national holiday celebrated annually in the Philippines. Rizal Day commemorates the work and life of José Rizal. José Protacio Rizal Mercado y Alonso Realonda (June 19, 1861 – December 30, 1896) was a Filipino nationalist, novelist, poet, ophthalmologist, journalist and revolutionary. 214 more words


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Loraine Margaret (Phillips) Berg was born on March 20, 1916, at her Grandmother Higley's home in Eau Claire. She was the daughter of William and Ella (Higley) Phillips.
She was baptized on October 1, 1916, and later confirmed at Second Congregational Church. Loraine married Glen Berg on June 29, 1935. For many years they enjoyed living in their house on the lake in Chetek.
Loraine worked for many years in the state income tax office. She was talented in so many ways. A few of her many talents included: baking, sewing, knitting, quilting and crocheting. She greatly enjoyed being an active member of her church, Plymouth United Church of Christ. At the church she was involved with many groups such as Busy Hands Circle, Happy Hours Club, served on the worship commission team and always attended Monday morning bible study class. Loraine was an avid Packer fan and always greatly enjoyed watching football. Apple fritters and string cheese were her favorite little snacks, and a sure way to put a smile on her face. She was known for her laugh and great sense of humor, she was always very content and happy spirited. We were blessed to have Loraine in our lives, she lived a long and healthy life. She was always very sharp and will always be remembered as the true spit fire she was even up until her last days.
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Elizabeth Horn, President of Horn Productions, Inc., said: "Having support from two successful Silicon Valley industry leaders is a dream come true for us. Our mission, to bring the 'good news about autism' to families that need hope so desperately, will only be fulfilled with help from caring individuals. They are making a real difference for people who need it most."
For more information about the "Light of Hope" Event, go to www.findingthewords.org.
"Finding the Words"
"Finding the Words," a documentary about children recovering from autism, takes viewers on a journey from tragedy to triumph, and invites parents to follow a similar path to get their children well again. It's a film about hope that provides practical solutions for addressing the various physiological disorders that may affect children with autism, and an inspired view of how those who are dedicated to a better future can change the world for all of us.
Horn Productions, Inc.
For the past twenty years Elizabeth Horn has been the president of Horn Productions, Inc., a San Mateo, CA based film production company specializing in high-end corporate films. The company enjoys a reputation as one of the leading production companies in the San Francisco Bay Area. Prior to her work in the production field, she was director of marketing communications for a number of Silicon Valley firms, as well as a marketing consultant to several start-ups. She has a thirteen year old daughter who is recovering from autism.
For information about NetSuite Inc., please visit www.netsuite.com<
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Below is the program for April 25th, 2015.
We have a survey this night, to help decide what replace the regular series that are finishing. Tonight is the final "Psycho-Pass", and "Nozaki-kun" has only a couple more episodes to go. There are so many good thing to add to the
program, yet the room is limited. Choose wisely.
All items in the original Japanese language with English subtitles.
|Fairy Tail
|Ep 161/175
|Gekkan Shoujo Nozaki-kun
|Ep 11/12
|Yoru no Yatterman
|Ep 1
|dinner break
|door prize drawing, and announcements
|Log Horizon season 2
|Ep 9/25
|Ep 6/12
|Ep 9/12
|Sword Art Online 2
|Ep 15/24
|Late Break
|Akame ga Kill
|Ep 2/24
|Psycho Pass season 2
|Ep 11/11
|(vd) final
|Ep 9/13
Doors Open Screening:~4:55 PM
Program Finishes:~10:45 PM
Dates of Interest
- Sunday April 26th – Maids in MyriadeLand (the board game cafe in Perth 2.98 Lake St, Northbridge) 2PM-6PM. Maid Club Perth will be bringing a Japanese Maid Cafe experience.
- Sunday April 26th – live action "Parasyte" movie, part 1. Carousel cinema, 4:30PM.
- Saturday May 2nd – JAFWA's Fundraising Bunnings BBQ at Cannington. Come buy a sausage in a bun. Or even volunteer your sausage sizzling skills. Also, Free Comic Book Day at various retailers.
- Saturday May 16th – PANIC SGM
- Saturday June 20th – JAFWA's next Event Afternoon, where we have the hall before JAFWA (from ~12:30PM to ~4:30PM) and make our own entertainment.
- July – JAFWA AGM and elections to the JAFWA committee.
Fairy Tail
Magic and mayhem in the nation of Fiore. The members of the infamous mage's guild Fairy Tail spend their days sorting out problems for the residents of Magnolia and battling the odd apocalyptic demon or dark guild. Of course they don't let little things like that get in the way of having fun.
Tonight's Episode: "Chariot"
Finishing last and second last after the first day's events of the Grand Magic Games is reason enough to celebrate, or perhaps just drown your sorrows, for Fairy Tail. Both losses in the one on one battles were due to outside interference; for Jellal/Mystogan it was his guild-members making sure he didn't blow his cover before investigating the arena and the dark magic he sensed from it in previous years. For Lucy, it was Raven Tail's cheating… which is why she and Grey, the other Fairy Tail guild member undone by their antics, aren't at the pub.
Gekkan Shoujo Nozaki-kun (Monthly Girl's Nozaki-kun)
High school student Sakura Chiyo has a serious crush on her tall, stoic schoolmate Nozaki Umetarou. But when she finally plucks up the courage to tell him she always wants to be with him, she finds herself employed as his assistant. Turns out Nozaki is a shoujo manga artist, and by working alongside him Sakura gets to see her high school crush in action … and see the not-so-perfect inspiration for his stories.
Tonight's Episode: "Let's Rice"
A typical day of work on Nozaki's manga gives Sakura a chance to learn a bit more about the relationship between Nozaki and his editor Ken, how they first started working together and what Ken first did that won him so much admiration from Nozaki (aside from not being his insufferable old editor Maeno).
Preview – Yoru no Yatterman (Yatterman of the Night)
The Yatterman were the heroes, the Yatterman saved the world. The Yattermen made a wondrous place for people the live; the Yatter Kingdom. So why keep Leopard and her friends out just because of their ancestor's crimes? Why do they no longer help those who are in need? Any why, when Leopard decides to force her way in to teach them a lesson, is the kingdom nothing like the stories? Who are the real heroes now?
Tonight's Episodes: "The World is Pitch Black"
A pleasant and uneventful New Year's Day in Japan, until the first of a vast swarm of comets, strikes the peak of Mount Fuji. And in fire and wrath, everything ends… Or perhaps not. In a simple graveyard, with the lights of a city in the distance, a pregnant woman wishes that her child will get to live happily in the Yatter Kingdom. Little Leopard grows up a cheerful and rambunctious child, raised on tales of the heroic Yatterman and their victory over the villainous trio Doronbo …
Log Horizon season 2
Life continues for Shiroe and the others trapped within the world of Elder Tale. The city of Akihabara is now prosperous and thriving thanks to the efforts and innovations of the adventurers. But prosperity does not guarantee safety, Shiroe's skills have already been tested against the nefarious Nureha and her guild Plant Hwyaden, and now he must find a way to secure Akihabara's future against those who would seek to claim it for themselves.
Tonight's Episode: "Guild Master"
After finding themselves in a seemingly unwinnable battle, three raid bosses all at once, Shiroe experiences death for the first time. He is forced to confront his inability to fully trust others, but he comes out of the experience ready to confront his flaws. However, the battle in which he died was a total party wipe-out, and the members of the Silver Sword guild are now doubting that this raid can be beaten at all. Their Guild Master, William Massachusetts, must now find the words to rebuild their confidence.
Kazama Kenji goal in life was simple; become a famous and feared delinquent. Instead he finds himself mixed up with his school's struggling Game Development club and its various … eccentric … members. Yet the harder he tries to get away from them, the more he finds himself running into the other crazies in his school.
Tonight's Episode: "That Means We're in a Love Triangle!"
The Battle with the 14 Devils upgraded Ken's status from unknown delinquent … to Chitose's lackey. And Chitose revealing his little sister makes his lunch dragged it back down again. He's also attending class, very un-delinquent like, but Mr Konekone is an exception. He saved Ken and his buddies from a burning building when they were kids, not even a delinquent would insult such an awesome teacher by skipping class. But now that his class is over, there's no reason for Ken to stick around … except for a terrified Roka begging for protection from her 'enemy'.
Noragami (Stray God)
Hiyori Iki is introduced to the world of spirits and deities after her first encounter with Yato, a homeless war god, results in a near death experience. Now Hiyori needs the ambitious Yato to help stop her soul from disconnecting from her body, but a god who doesn't even have a shrine, let alone worshippers, doesn't really inspire much confidence.
Tonight's Episode: "Name"
Whilst Yato managed to help the bullied kid at Hiyori's school, the environment is the last straw for Yuki. Seeing everything he lost when he died and became Yato's Regalia sends him into a destructive rampage across the school. It is also the last straw for Yato, as the corruption Yuki's negative thoughts have caused finally overcomes him. Hiyori brings Yuki and the now unconscious, and infectious, Yato to Kofuku for help … only to have a barrier thrown up in front of them.
Sword Art Online 2
It has been a year since the victims of Alfheim Online were freed from their virtual prison, and more than a year since Sword Art Online was shut down. But now it has begun once again. A mysterious figure has been making appearances in the game Gun Gale Online, and other players drop dead in their wake. Kirito finds himself once again risking his life in the online world.
Tonight's Episode: "Queen of the Lake"
Shinkawa and his brother are now behind bars, the Death Gun incident is finally over and Kirito can return to Alfheim online. Which is good timing since the legendary sword Excalibur has now been spotted by other players in the game. Kirito and his sister discovered it some months ago and he had always planned to come back to it at some point. Now that other players know it is there for the taking, the race is on to be the one that claims the legendary sword.
Akame ga Kill
Tatsumi was hoping to find enough money in the capital to save his poverty stricken village, what he found instead was corruption and slaughter. The prime minister is the power behind the throne, manipulating the infant emperor for his own gain, and the common folk of the empire suffer under his reign. A group of assassins known as Night Raid prowl the city, leaving a trail of corpses in their wake. But as Tatsumi quickly discovers, they may be the only hope the empire has.
Tonight's Episode: "Kill the Authority"
Despite his heart-wrenching introduction to the darker side of life in the capital and the loss of his friends from the village, Tatsumi still isn't completely sold on the idea of joining the rather eccentric Night Raid. Still, he has been brought to their hideout (which limits his options), so Leone introduces him to the rest of the group.
Psycho-Pass 2
Makishima Shougo is dead, and Akane Tsunemori still works for Public Security. With a new junior inspector and two new Enforcers she struggles to protect the public from the latent criminals in their midst, whilst hiding from them the horrible truth of the Sybil System. But a new menace walks the streets, a new threat that once again cannot be judged by Sybil. And this time they're not just a lone psychopath, this time they're recruiting.
Tonight's Episode: "What Colour?" Finale
Kamui's purpose in hijacking and terrorizing so many people was to overload Sybil with judgements so he could pinpoint its location. Sybil meanwhile tries to kill them all with explosives, and tries to get Akane to push the button by revealing what happened to her grandmother (but not who actually did it). Akane, however, is no one's fool. She knows all about Enforcer Tougane, and his mother. Instead, she's going to bring Kamui to Sybil so that it can be judged. The system will be forced to evolve.
Hope's Peak Private Academy is a famous boarding school, known as a place for students who are the best in their field. When the unremarkable Makoto Naegi wins a lottery to enter the school he and fourteen other new students find the horrible truth hidden within; Hope's Peak is a prison, and the only way out is to kill one of the other inmates without getting caught.
Tonight's Episode: "The Junk Food of Despair for Racing Through Youth"
For the first time, a death in Hope's Peak Academy was not a murder. Oghami Sakura took her own life in order to allay the suspicion and mistrust that arose from learning she was the mastermind's agent amongst the students. Deprived of a student to execute, Monobear instead gets his amusement by revealing he has found the laptop with Alter Ego, and destroying that instead. But Kirigiri's solo investigations have turned up another bombshell. There is a sixteenth student somewhere in the school with them; Ikusuba Mukuro, the Super Duper High School Student of Despair.


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Offices Closed for Independence Day: All county offices will be closed on
Friday, July 3, for the holiday. This includes parks offices, public works, courts and all other administrative offices. Offices will re-open Monday, July 6.
Current Election Information
June 13, 2015 Joint General Run-Off Election:
General Election Information
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