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Another section of Manteca's planned 20.7 miles of separated bicycle paths was put in place this week.
LATHROP - River Islands at Lathrop is just the latest in a series of bold investments by a firm that traces its roots back to 1854 in England when it got its start managing and owning the famous Tea Clippers.
Janet Powell McKee hopes that her new book – entitled "Counseling Letters to God: A Psychological Paraphrase of Psalms" – will help make a difference in the lives of those who read it.
Seven new members are joining the Manteca Youth Advisory Commission.
RIPON - A corps of Ripon volunteers is stepping up to the plate to knock down weeds that the reduced numbers of city workers have not had time to touch.
Theresa Daniels and her husband, Rodney, are missing being a part of Sierra High.
One of the two missing gaps on Atherton Drive will break ground this fall.
Manteca is on pace to again lead the Northern San Joaquin Valley in housing starts.
The 2010 Manteca Idol season is officially underway.
RIPON - The City of Ripon got on board Tuesday night with a state mandated Assembly Bill 2572 ruling that water meters be installed on all residential properties in the community.
Manteca's elected leaders have created an on-street handicapped parking space in front of 221 N. Poplar Ave. to accommodate a resident who does not have a driveway.
A regional government consortium consisting of 16 of the San Joaquin Valley's largest cities from Stockton to Bakersfield is trying to devise a collective approach to "sustainable growth."
For the first time in about half a century, a dinner-dance will be held to kick off the annual St. Anthony's Harvest Festival.
It's a safe bet playing at the upcoming Manteca-Lathrop Boys & Girls Club Texas Hold 'Em & Bingo Night will benefit kids.
STOCKTON – The San Joaquin County Office of Education will dedicate the Education Service Center today in honor of Manteca resident and recently retired Superintendent of Schools Fredrick "Rick" Wentworth.
The stories come all too frequently.
Cecily Ballungay smiled as she chatted with elected officials, developers and the titans of Manteca's businesses community beneath a shade structure at the Matthews home at Delicato winery.
A Tracy motorist was ordered to stand trial for his part in a June 11 road rage incident on Highway 99.
Baby JoJo, an 18-month-old toddler involved in a Fathers' Day crash at Airport Way and Lathrop Road, died of his injuries Wednesday at the Oakland Children's Hospital.
Farmers in at least two California irrigation districts - South San Joaquin and Oakdale - are considering whether to ignore a letter from the state calling for historic cuts in water use during the drought, a lawyer said Thursday.
Manteca Unified is launching educational tours for community members this fall to help people understand how the Going Digital initiative is being used to enhance learning in the classroom.
Vince Hernandez believes the time has come for serious movement toward the city expanding Manteca's library facilities.
A bookmobile is coming to a Manteca park near you.
Enforcement and rebates to save water are trumping further restrictions so far in the Manteca Citizens Committee on Water Conservation's deliberations.
The South San Joaquin Irrigation District is not going to sign documents that say they will comply with the curtailment order issued to pre-1914 water right holders nearly two weeks ago by the state Department of Water Resources.
The Spring Creek Golf and Country Club usually gets nostalgic come this time of the year.
The Manteca Unified School District board wanted to do as much as possible to make Tuesday's meeting about the appointment of a trustee to fill the vacant term left by Alexander Bronson's resignation.
The California Attorney General's office stunned senior water rights holders in San Joaquin County Superior Court Tuesday by stating State Water Resources Control Board curtailment orders have no teeth.
Nicholas Tejeda will be leaving Doctors Hospital of Manteca on July 3 as its chief executive officer for a similar post in El Paso at the Sierra Providence East Medical Center.
The sun shaved $1.4 million off the Manteca Unified electricity bill during the first full year that solar panels were in place at 25 campuses and the district office complex.
Contents of this site are © 2015 Manteca Bulletin - All Rights Reserved Privacy policy and Terms of service | Contact Us


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What color/themes are you planning for your nursery?
Comments (9)
I am thinking green, not really sure if I want to paint the room but we will see. DH and I really are not good painters, the rest of our house we painted and it's not so good lol. But I already got a green-ish neutral bedding set, this baby's gender will be a surprise and luckily my fave color is green.
Nikon D7100 Momtogapher www.facebook.com/kldpic
Crunchy, CDing, BWing, BFing, Vaxing mommy to 3
| SUPERMOM | wife | student |
Boy: gray walls, navy accents (we already have a navy rug and navy blackout curtains from my DS), aqua blue.
Girl: gray walls, navy rug and curtains, watermelon pink, yellow.
No "themes" for either. Just colors and textures. I'm thinking fabric hoops in a girl's room, and maybe canvas art my DS made for a boys room.
Cara ODS 4.5 *SPD, Speech delays YDS 2 *ASD, Speech delays
Grey walls. Blue and orange accents for a boy; turquoise and purple for a girl.
We don't really do themes--my son's theme is "circles" in a very modern way. This baby's nursery will be similarly modern--we are thinking elephants, too, but in a very non-obvious abstract way.
We are doing a gender neutral nursery. We love reading and want to instill that in our children. We are going with an ABC theme with bright colors. We are going to stay way from the generic neutral colors though - most nurseries I see with a lot of browns and neutrals look sad and not child-like at all, so we want bright and bold colors.
To give you an idea of our inspiration nursery, check this out (minus the airplanes...just the overall feel of the room and the ABC wall):
We also like some of the ideas of this nursery. They framed pictures of children's book covers! This is an adorable and inexpensive decorating idea. The image is from this site and is found on image 2: www.hgtv.com/decorating/10-decorati...
I also have a "For future reference" board if anyone is interested in seeing some more ideas we have.
Kendra (27) & Tom (30)
Married October 23, 2010
Wyatt Alexander born July 1, 2013
Baby Girl due July 2, 2014
Gender Neutral here, going with stars and moon theme and bears.Thinking about green tone walls.
Married to Chad on June 2nd, 2012
Expecting our first on July 4th, 2013 :)

subset: commoncrawl


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XPS_JOB_STATUS structure
[XPS_JOB_STATUS is not supported and may be altered or unavailable in the future. ]
Contains a snapshot of job status.
typedef struct _XPS_JOB_STATUS { UINT32 jobId; INT32 currentDocument; INT32 currentPage; INT32 currentPageTotal; XPS_JOB_COMPLETION completion; HRESULT jobStatus; } XPS_JOB_STATUS;
- jobId
The spooler job ID that is assigned to the print job. If no job ID has yet been assigned, jobId will be 0.
- currentDocument
The zero-based index of the most recently processed document in the print job; 0 is the first document, 1 is the next, and so on. If no documents have been processed, currentDocument will have a value of -1.
- currentPage
The zero-based index of the most recently processed page in the current document; 0 is the first page, 1 is the next, and so on. If no pages have been processed, currentPage will have a value of -1.
- currentPageTotal
A running total of the number of pages that have been processed by the print job. At the beginning of the job, this value is 0. As each page in each document is processed by the job, this value increases monotonically.
- completion
The XPS_JOB_COMPLETION value that indicates the completion status of the job. This value will change when the event passed in the completionEvent parameter of StartXpsPrintJob is signaled at the end of a job. If the print job fails, this value will be XPS_JOB_FAILED, with jobStatus containing the error code of the failure.
- jobStatus
The error state of the job. If the job finishes without an error, this value will be S_OK. If an error causes the print job to exit, this value will be the error code of the failure.
Minimum supported client
|Windows 7 [desktop apps only]
Minimum supported server
|Windows Server 2008 R2 [desktop apps only]
End of client support
|Windows 8.1
See also


text:
Apple Store
Carrefour Laval
3035, boulevard Le Carrefour, local C14BLaval, Quebec H7T 1C8
(450) 902-4400Driving directions and map
|Store hours:
|Mon - Fri:
|10:00 a.m. to 9:00 p.m.
|9:00 a.m. to 5:00 p.m.
|10:00 a.m. to 5:00 p.m.
Apple Store
Carrefour Laval
3035, boulevard Le Carrefour, local C14BLaval, Quebec H7T 1C8
(450) 902-4400
How to get here:Back
The Apple Store is located in Carrefour Laval in the La Baie wing, opposite American Eagle Outfitters. Carrefour Laval is located on the North Shore of Montreal, near the intersection of Autoroute 15 and Autoroute 440. Parking: North end of the mall, near La Baie. Public transit: Montmorency Station on the Orange Line; STL bus; or express bus #902 from Côte-Vertu Terminal.
Apple Camp
Free workshops where kids can make their own movies or interactive books.Learn more
Schedule a try-on appointment.
Make an appointment to try on Apple Watch in an Apple Retail Store.Learn more
Reuse and Recycling Program
Get credit when you recycle your eligible iPhone, iPad or select smartphone from another manufacturer.
Personal Setup
We can help you set up your Apple Watch the way you like. And we'll point out some great apps to help you personalize it.Learn more
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Service tools
Navigation path
Selection results
Applications by country
Selection results of the Development – Single Projects, deadline 1, EACEA/17/2014 have been published.
Read more
Selection results of the deadline 22/01/2015 for the Access to Markets call (EACEA/29/2014) have now been published
Selection results of the first deadline (04/12/2014) for the Distribution Selective Support call (EACEA/23/2014) have now been published.
Selection results have been published.
Call for proposals has been published.
All News


text:
Tori Spelling Lops Off Her Hair; Shares Photo on Instagram!
Tori Spelling shared her new hair do on Instagram today. The actress, who decided to lop off her locks on a whim late last night, captioned the photo: "Here's my new hair cut.I Chopped it all off myself last nite at midnite. #FutureHairStylist #ShortHairDontCare #MultitaskingMama"
What do you think of her new look?
Source: Instagram
Spelling's first major role was Donna Martin on Beverly Hills, 90210 in 1990. She appeared in a string of made-for-television films, such as A Friend to Die For (1994) and Mother, May I Sleep with Danger?(1996). Spelling also rose to prominence through independent films such as The House of YES (1997), Trick (1999) and Cthulhu (2007). She reprised her prominent role in the spinoff, 90210, in 2009.
Her autobiography, Stori Telling, debuted on top of the New York Times Best Seller list and was named the best celebrity autobiography of 2009.
About Author
- CNBC to Air THE MAKING OF DIG, the USA Network Event Series, 3/1
- NBC to Air One-Hour Season Finale of CHRISTINA MILIAN TURNED UP, 3/1
- NBC Universo to Present ROMEO SANTOS DESDE VINA Concert Exclusive, 3/1
- Kelly Clarkson to Visit CBS SUNDAY MORNING, 3/1
- VIDEO: Clark Gregg Teases New AGENTS OF S.H.I.E.L.D. Season Using Emojis
- Dakota Johnson to Host SNL Tonight; Alabama Shakes to Perform
- NBC Sports to Air Coverage of U.S. GRAND PRIX FROM PARK CITY
- Discovery Family to Premiere New Episodes of TRANSFORMERS RESCUE BOTS, Today
- Telemundo to Present FUTBOL ESTELAR: LEON VS SANTOS, Today
- Telemundo to Give Viewers Sneak Peek at Upcoming Programming on LO NUEVO, Today


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- About
- Adopt & Help
- Donate
- Events & Fun
- Rabbit Care
- Services
- Shop
Hi! Nice to meetcha. I am a cute little girl, born August 17, 2004. I'm the adventurous one!
My rabbit family and I are used to getting a lot of love and attention as we are living in a foster home with a great human mom and dad and 3 kids.
I would like to be adopted along with one of my rabbit siblings or as a companion for your rabbit, so I won't get lonely. I'm ready for fun and adventure. Please adopt me soon!
Tired of wasted hay being kicked all over or wet hay that gets um..."tinkled" on?
We've created a space efficient and elegant way to give your little fur friend the fresh, clean hay they love and need for a proper diet.


text:
Special requirements
Students must complete 37 credits in chemistry and 16 to 18 credits of collateral requirements.
A minimum grade of C is required in each prerequisite course: CHEM 100 Introductory Chemistry (if required through placement qualifiers), CHEM 101 General Chemistry, CHEM 102 General Chemistry, CHEM 301 Organic Chemistry and CHEM 302 Organic Chemistry.
The curriculum in chemistry prepares students for graduate study in chemistry and related fields and for admission to schools of medicine, dentistry, pharmacy and veterinary medicine. It prepares students to teach in secondary schools or to work in chemical and industrial laboratories and in related fields of business and industry. The department also offers required and elective courses in chemistry to students in other programs of study.
The Department of Chemistry offers five areas of concentration for completing the Bachelor of Science in Chemistry: chemical science, professional chemist, professional chemist with honors, biochemistry and chemical modeling. With proper selection of electives, the degree satisfies admission requirements to most schools of medicine, dentistry, pharmacy and veterinary medicine.
The chemical science concentration is tailored for the pre-professional study of the health sciences and other interdisciplinary areas where an emphasis on chemistry is sought. This concentration for the bachelor's degree in chemistry permits students to select more courses from other disciplines. With fewer requirements in mathematics, physics and chemistry, this concentration is one option for students planning to study medicine or dentistry.
Learning outcomes
|General Education requirements (32-46 credits)
|University Core Education Curriculum (minimum 21 credits)
|UNIV 111 Focused Inquiry I
|UNIV 112 Focused Inquiry II
|UNIV 200 Inquiry and the Craft of Argument
|Approved humanities/fine arts
|Approved natural/physical sciences
|Approved quantitative literacy
|Approved social/behavioral sciences
|Additional College of Humanities and Sciences requirements (11-23 credits)
|HUMS 202 Choices in a Consumer Society
|Approved H&S diverse and global communities
|Approved H&S general education electives
|Approved H&S human, social and political behavior (fulfills University Core social/behavioral sciences)
|Approved H&S literature and civilization (fulfills University Core humanities/fine arts)
|Approved H&S science and technology (fulfills University Core natural/physical sciences)
|Experiential fine arts (course offered by the School of the Arts)
|Foreign language through the 102 level (by course or placement)
|Collateral requirements (16-18 credits)
|MATH 200-201 Calculus with Analytic Geometry
|PHYS 201-202 General Physics or PHYS 207 and PHYS 208 University Physics I and II
|STAT 210 Basic Practice of Statistics or STAT 212 Concepts of Statistics (fulfills quantitative literacy)
|Major requirements (37 credits)
|Chemistry core (34 credits)
|CHEM 101 and CHEZ 101 General Chemistry and Laboratory I
|CHEM 102 and CHEZ 102 General Chemistry and Laboratory II
|CHEM 301 and CHEZ 301 Organic Chemistry and Laboratory I
|CHEM 302 and CHEZ 302 Organic Chemistry and Laboratory II
|CHEM 303 and CHEZ 303 Physical Chemistry and Laboratory I
|CHEM 304 Physical Chemistry
|CHEM 309 and CHEZ 309 Quantitative Analysis and Laboratory
|CHEM 320 Inorganic Chemistry I
|CHEM 398 Professional Practices and Perspectives Seminar
|Chemistry elective (3 credits)
|Choose at least one of the approved electives below (three credits minimum) or any 500-level CHEM class for which prerequisites have been met.
|Open electives (19-35)
|Open electives
|Total minimum requirement
CHEM 306/CLSE 306 Industrial Applications of Inorganic Chemistry
CHEM 310/MEDC 310 Medicinal Chemistry and Drug Design
CHEM 401 Applications of Instrumental Techniques in Organic and Forensic Chemistry
CHEM 403 Biochemistry I
CHEM 404 or Biochemistry II
CHEM 406 and CHEZ 406 Inorganic Chemistry and Laboratory II
CHEM 409 and CHEZ 409 Instrumental Analysis and Laboratory
CHEM 492 Independent Study
CHEM 493 Chemistry Internship
CHEM 510 Atomic and Molecular Structure
CHEZ 304 Physical Chemistry Lab
Click here to download a sample outline.
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Virginia Commonwealth University
Richmond, Virginia
Contact us: email@example.com
Last update: 7/2/2013
The VCU Bulletin is in transition! As we move from this first iteration of our online Bulletin to a new product and process, what you find on this website is information for the 2014-15 academic year.
While much of the curricular information remains the same, changes that were approved with the effective date of fall 2015 will not be reflected on this website. Prospective students may wish to contact the school or department that administers their program of interest in order to discuss the most current curriculum and concentration options.
Enrolled students who are completing their studies under an effective Bulletin may continue to access the archives at http://www.pubapps.vcu.edu/Bulletins/archives.aspx, where past Bulletins are available to reference or download.
Our anticipated launch of the new VCU Bulletin is July 2015. To follow our progress, visit the new Bulletin blog.


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covering over 29,115 products. See what the press says about ReviewGist here.
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text:
Transition Richmond Message Board › community garden/Urban farm 1.5 ac meeting place, learning environment
|Ken D.
user 10851211
Richmond, VA
Hi, I just joined this group and wanted to introduce myself and offer up a possible project for this group. I have a 1.5 ac piece of land with a 2 story garage/barn on it, electricity and water. It was a florist/greenhouse operation at one time and presently has the old greenhouse and retail building on it which I will be demolishing soon because of it's condition and obsolescence. I've been trying to get people interested in creating a community garden/Urban farm on this property for a few years now although I must admit, I haven't been trying as hard as I could! It's located on Cool Ln, near Farm to Family, easy access from I95, I64, Rt 360 on the back end of Church Hill, it's not the best neighborhood, but not the worst either!
My vision is to create an environment, an incubation zone keeps popping up in my mind, where like minded people can gather, grow food, work on natural building techniques, sustainability, self reliance and the things this group seems to foster, with a opportunities to expand on those concepts on a 40 acre farm we presently live on in King and Queen county. We moved out of Richmond 6 years ago after... do I dare say... living downtown for 24 years, the last 18 in Jackson Ward where we still own the house we bought and renovated. We've been learning to farm naturally starting with vegetables, then, we realized we needed to add animals to the farm to help balance the system. We now have heritage pigs including a litter 9 days old today along with their mama and a group of 11 that are 13 weeks old, unfortunately, their mama died after raising them 9 weeks and weening them... she had them July 3rd, in the middle of that intense hot spell we had and never fully recovered, she sacrificed herself for her young. We also have a flock of heritage Spotted Sussex chickens that are natural free rangers including one hen who is sitting on a clutch of eggs and should be hatching them in about 2 weeks!
Anyway, as you might imagine, I have my hands full! I'd love to find someone or... a ... group... of people that would like to help push forward on this concept. The urban farm property sits, underutilized and could be transformed into a vibrant gathering and learning place.... anyone interested?
I also have a bunch of alternative energy stuff to play with... love to build some cabins on the farm... rocket stoves... cob pizza ovens... the list goes on!
|Heather H.
user 11493343
Richmond, VA
This sounds like a great opportunity for some re-skilling workshops! I look forward to talking to you about this more at our meeting!
user 20610931
Arlington, VA
Hope you check out the Richmond Cohousing meetup and come to a meeting! Our group is going to need a site!
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


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The Coolest Graphic Design Projects on Kickstarter
Kickstarter is a great way to fund creative, innovative projects that might not otherwise reach the masses. And while it's often the cool gadgets that get the spotlight, you can find some great stuff in the Graphic Design category, from posters (those seem to be particularly popular) to games and things like books and playing cards.
Below are some of the coolest recent projects in the graphic design category – including two that you can still fund (but hurry, one of them closes later this afternoon).
Seen any cool graphic design projects on Kickstarter that you think we should review? Let us know.
The Beautiful Bicycle Print
Designer: Andy Scullion
Status: 158% funded on August 2
Learn more: http://www.etsy.com/uk/shop/AndyScullion | @wyatt_design
Designer and bike devotee Andy Scuillion combines his two great loves with this print. Scuillion understands that bike lovers like him... keep reading


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Stock Photo:
Tiny people climbing ladders to get to the top. Teamwork concept
- Image ID: 113049874
- Copyright: Mopic
High quality images curated from over 150 countries.
Over 50 million photos, vectors, illustrations, and more.
Simple and flat pricing by image or by month.
Over 230,000 images downloaded every day.


text:
MINI to Produce 3 Door Beachcomber Variant?
Scott26 (or whatever name he's going by today) has long been a great source of information for BMW fans. He works for the company and has insider information that is often on target years before a new model is launched. So that makes this new rumor Scott27 rumor all the more interesting to MINI fans.
As we have reported last May MINI is seriously considering putting a version of the Beachcomber into production in the coming years. But what form will it take? That's where we pick up Scott27's latest insider information. But one quick caveat before we get to that. The following is his opinion and not ours. While it seems very plausible (and we hope it's correct) we know first hand how quickly product decisions can be made and then reversed. Now we turn it over to Scott27:
With the expansion set to continue with MINI we are looking at alternatives to widen out the MINI Brand with a new model expansion that will be inherited with the Countryman and the next generation MINI.
The beachcomber Concept was an idea to officially preview the Countryman in light of the MINI Crossover Concept.
The Problem with the Beachcomber is that not everybody is around sea and sand 24/7 especially for a five door concept. Whilst the Beachcomber is a practical solution for a surfer or triathlete and their friends , it does not sit well with the corporate image of having a five dr beach orientated vehicle.
A Solution once conceived in 2005 by the MINI design team is a 3dr more sport orientated activity MINI which is being looked at as a brother vehicle to the MINI Countryman. Using the Countryman's platform but shortened and All4 four wheel drive drivetrain.
MINI Canyon is an idea that takes the formula as used with the MINI Coupe but translates that to a small Activity MINI , utilising 3drs and space for four.
Comparisons with the Land Rover Evoque are welcomed but MINI had this idea in 2005 and before that.
What is unique is the unusual "Origami" roof line that like the Evoque swoops down giving the car and extremely dynamic roofline which seperates two rear windshields , as shown here a full sized spare tyre is retained , but the design also utilises a luggage box built into the roof for extra flexibility. Aswell as removable roof panels which would make a Beachcomber more possible with this car.
The car is on the Design wall in Munich to decide how to further progress the MINI portfolio. And the overall look remains but the details will be brought into line with the other MINI family.
The proposal goes that if the MINI can spawn a Coupe Can the MINI Countryman propose a smaller 3dr activity Concept.
Official decision has not been taken but it looks likely that the MINI Canyon could become a reality. Although Canyon is the design project name it could retain the original title or use a classic MINI title or something new.
Written By: Gabe
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- //Music
- //The Smithereens
The Smithereens are a great power-pop bar band. That may read like an oxymoron, but it's the truth. Vocalist Pat DiNizio might sing the lost-my-girl-blues with songs like "Only a Memory" and "Drown in My Own Tears", but his fellow band mates—guitarist Jim Babjak, drummer Dennis Diken, and bassist Severo Jornacion—also help him work up a powerful head of steam. Sure, you can pick up these songs on a greatest hits collection. But it's far better when DiNizio sings his great line, "She stood just like Bill Wyman", in front of a sweaty, beer-soaked audience. Many of these songs are a few decades old now, but you wouldn't gather that from this live date. It still sounds like there are a few open wounds left. Better still, in addition to the group's high-powered musical pain formula, there's also a cover of the Batman theme tacked on at the end.
- Multiple songs MySpace
Colette Carr "Static" (video) (Premiere) // Music
House of Blondes "First of July" (audio) (premiere) // Music
Digisaurus 'No More Room For Love' (EP stream) // Music
Fave Five: Alpine
// Sound Affects
"Australian sextet Alpine's newest album is a fantastic expansion of their joyous pop sound, but two members give us five records apiece that helped define their unique musical identities.READ the article


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Fisherman's Chowder
19 Aug 2010
|Yellow perch fillets/Bass / substitute fillet
|1 1⁄2 Pound, skin removed, cut into 1 inch pieces (Each Fillets Of 6 Ounces)
|All purpose flour
|1⁄4 Cup (4 tbs)
|2 Tablespoon
|Canned condensed cream of mushroom soup
|21 1⁄2 Ounce (2 Cans, 10 3/4 Ounce Each)
|2 Cup (32 tbs)
|Peeled diced red potato
|2 Cup (32 tbs) (3 Medium Ones, Cut Into 1/2 Inch Cubes)
|Chopped carrots
|1 Cup (16 tbs)
|Canned lump crabmeat
|6 Ounce, rinsed, drained and cartilage removed (1 Can)
|Chopped celery
|1⁄2 Cup (8 tbs)
|Dried parsley flakes
|1 Tablespoon
|Dried dillweed
|1⁄2 Teaspoon
|Garlic powder
|1⁄2 Teaspoon
|1⁄4 Teaspoon
In shallow mixing bowl, combine perch pieces and flour.
Toss gently to coat.
In 6-quart Dutch oven or stockpot, melt margarine over medium-high heat.
Add fish.
Cook for 3 to 5 minutes, or until lightly browned, stirring constantly.
Add remaining ingredients.
Bring to a boil over medium-high heat.
Reduce heat to low.
Simmer, uncovered, for 30 to 40 minutes, or until fish is firm and opaque and just begins to flake, stirring occasionally.
Recipe Summary
Difficulty Level:Easy
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Fisherman's Chowder Recipe


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Unapologetically bold as brass, the Roadhouse is an American-inspired diner overlooking the hubbub of Covent Garden Piazza. Slot into a booth and tuck into generous portions of unpretentious American staples such as burgers, fajitas and grills. With live music every night and a 60-strong cocktail list, whipped up by one of the flamboyant bartenders, it can also cater for large groups and parties.

Please note that the Roadhouse is strictly an over 18's only venue.
This content has been supplied by Roadhouse
Events at Roadhouse
Venue Details & Map
- Address
35 Covent GardenCovent GardenLondonWC2E 8HB
- Public transport:
- Covent Garden, Underground
One of recommendations when I visited London.
My cousin and his wife live about 3 hours away from London though they had been to this place a couple of times. Ambience was good as i really don't know what to expect. As dinner time passes by, they do hold live bands for entertainment. Its kind a weird for me as when do they take a break, then it turns into a clubby scene for like 20 minutes...more
Love the atmosphere here, food is great and drinks are reasonably priced.
It's open til 3am which is good for an after-event to wind down whilst still listening to music and able to dance.
The staff are all very friendly too.more
I have been to Roadhouse a few times now, and overall I love it!
The first time I tried to participate in Rockaoke on a Wednesday I got there too late to sign up (9.15pm), so GET THERE EARLY on a Wednesday if you want to sing! They were really good about it and the three of us got a free drink each as apology, and we had a really good night in the end (despite me starting out so...more
Set in the heart of covent garden this underground venue takes you back to the 1960's American dar/dinner experience with the bright red shiny coloured booths in one area and the tables and seats everywhere else coupled with the art work all over the walls but for me it is the Harley Davidson sitting on the top self of the spirits section in the middle of the central bar.
There are smaller bar...more
This is Not a bad review- it's just not a good one.
When someone said 'lets go to the Roadhouse' I agreed as I mistook it for another place around the corner. Surprised we were headed for the heart of Covent Garden.
My first thought *oh god tourist trap* and I was right. It's a big garish place with motorbikes and neon lights here there and everywhere. A big bar surrounded by tables and...more


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Getting regions and cities 'right', adapting policies to the specificities of where people live and work, is vital to improving citizens' well-being. View the country fact sheets from the publication OECD Regional Outlook 2014.
Regions and cities are on the front lines of many challenges faced by OECD countries today, from education and jobs to health care and quality of life. Getting regions and cities "right", adapting policies to the specificities of where people live and work, is vital to improving citizens' well-being. This second edition of the OECD Regional Outlook aims to help countries do just that. Part I describes the main trends and
How's life? The answer can depend on the region in which you live. Many factors that influence people's well-being are local issues, such as employment, access to health services, pollution and security. Policies that take into account regional differences beyond national averages can therefore have a greater impact on improving well-being for the country as a whole.
This report presents the OECD analytical framework for
The International Forum on Open Government gathered open government leaders from around the world in order to debate the contribution of the principles of transparency, accountability and citizens' participation to good governance and socio-economic development.
The OECD Open Government Reviews are a series of reports analysing open government policies and practices in countries. The reports examine institutional and legal frameworks for implementation against OECD instruments.
The workshop on "Learning from crises and fostering the continuous improvement of risk governance and management", jointly organised with the governments of the Netherlands, Norway and Sweden, was held in Oslo, Norway on 17-18 September 2014.
This report summarises the results of the joint project of the Greek Ministry of Administrative Reform and e-Government and the OECD on measuring and reducing administrative burdens in 13 key sectors of the Greek economy.
On 22-23 September 2014, the Danish Government and the OECD will organise the next meeting of the OECD Network on E-Government (E-Leaders 2014) in Copenhagen, Denmark to discuss "Improving Governance for Better Digital Strategies".
Cities are home to over half of the world's population. Cities characterise many of today's global economic and environmental challenges and deliver cost-effective policy responses. Latest news: Policy Perspectives on Cities and Climate Change.
Helping improve public governance and management in European Union Candidate Countries, Potential Candidates, and European Neighbourhood Policy partners is the mission of a joint OECD-EU initiative, the SIGMA programme.


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chicken, cock, bird, comic, grin, face, happy, funny, witty, cool, smile, Design, Style, crazy, head, smiley, nice, laugh, egg, motif, hot, cartoon, cockscomb, farm, motif
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The quintessential treatment before you bare your back. Get a full back exfoliation using Visage microbeads and a body brush to reach areas you did not know existed, to get a beach ready back. We can also tailor this treatment to treat the back of thighs or buttocks depending on your problem area. Suitable for both men and women.
If you have acne on your back and are concerned, please call us first as we will try to schedule you in for a more thorough/longer consultation to keep the problem in check. We would however be able to offer other management to get the acne under control and potentially in beach shape.
Skin Clinic
Online bookings let you pick date/time for your visit.
If you purchase an eVoucher you will need to book with the venue directly.
Our old Wahanda Gift Vouchers can still be redeemed at over 3,000 locations. Use them to pay as you would with cash. Please note, the Wahanda Gift Voucher's successor – the Wahanda Gift Card – can only be used for online purchases.


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Civil War Soldiers - Confederate - MS
These records contain card abstracts of entries relating to each soldier as found in original muster rolls, returns, rosters, payrolls, appointment books, hospital registers, Union prison registers and rolls, parole rolls, and inspection reports. They may also contain the originals of any papers relating solely to a particular soldier. Browse by military unit, then name of soldier, or use the search box related to this title.…More
Watch! Receive email when more records or Member Discoveries are added.Watch
Recent discoveries in Civil War Soldiers - Confederate - MS
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Compiled Service Records of Confederate Soldiers Who Served in Organizations from the State of Mississippi. Original data from: The National Archives
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Crail, Fife, Scotland Show on map
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Crieff, Perthshire, Scotland Show on map
|Serviced hardstanding electric pitch
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Haggerston Castle Holiday Park
Berwick-upon-Tweed, Northumberland, England Show on map
|Electric hardstanding touring pitch (no awning)
|8 x
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|Electric hardstanding touring pitch (with awning)
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Mortonhall Caravan & Camping Park
Edinburgh, Lothian, Scotland Show on map
East Calder, Lothian, Scotland Show on map
Belhaven Bay Caravan & Camping Park
Dunbar, Lothian, Scotland Show on map
Craigtoun Meadows Holiday Park
St Andrews, Fife, Scotland Show on map
Aberfoyle, Stirlingshire, Scotland Show on map
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PRLog - Aug. 7, 2012 - NEW ROCHELLE, N.Y. -- Contact: John Sterling, Ph.D 914-740-2196, email@example.com
Genetic Engineering & Biotechnology News Unveils "Biotech Boulevard"
New Rochelle, NY—Genetic Engineering & Biotechnology News (http://www.genengnews.com)
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Compete for the opportunity to represent the United States in international competition.
See the entire Los Angeles City Section Division I bracket as teams vie for a CIF title.
See the results from the top high school football games in Southern California.
Team: Football ( Prep2Prep - 8/26/2014)
Team: Football ( Prep2Prep - 7/28/2014)
Team: Football ( SportsJournalLA - 9/13/2013)


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Posted| Updated
A baby Colobus monkey is welcomed to Canberra's National Zoo and Aquarium, the first to be born at the zoo in 11 years, but the paternal lineage of the new addition is in question.
Topics: animals, zoology, zoos, act, canberra-2600
Makaia the tree kangaroo was saved after being transferred into the pouch of a surrogate wallaby mother.
Topics: animals, lifestyle-and-leisure, zoos, adelaide-5000
Posted| Updated
A tree kangaroo joey, which has been saved after being transferred into the pouch of a surrogate wallaby mother, makes its first public appearance at Adelaide Zoo.
Topics: animals, human-interest, animal-science, zoos, adelaide-5000, sa, australia
Lions will return to Rwanda for the first time in more than two decades after the endangered animal was wiped out in Rwanda's human genocide.
Topics: animals, animal-behaviour, animal-attacks, zoos, national-parks, conservation, rwanda, south-africa, tanzania-united-republic-of
Topics: zoos, animals, perth-6000
Topics: animals-and-nature, zoos, perth-6000
Melbourne Zoo's baby pygmy hippo takes a dip in the big pool for the first time.
Topics: animals, human-interest, zoos, melbourne-3000
Posted| Updated
Tigers, lions, jaguars, bears, wolves and hippos roam the Georgian capital Tbilisi after deadly flooding turns their zoo enclosures into "a hellish whirlpool".
Topics: zoos, floods, disasters-and-accidents, animals, animal-welfare, georgia
Posted| Updated
Melbourne Zoo's new baby pygmy hippo, the first to be born at the zoo since 1981, makes its media debut.
Topics: animals, human-interest, zoos, melbourne-3000
Posted| Updated
A female gorilla at Melbourne Zoo has died of complications from injuries inflicted by a young male silverback gorilla.
Topics: zoos, zoology, death, melbourne-3000, parkville-3052
Posted| Updated
A colony of little penguins from Sydney's Taronga Zoo makes a debut at the Bronx Zoo in the US as part of a breeding program.
Topics: animals, animal-science, zoos, human-interest, united-states
Posted| Updated
Primate handlers at Taronga Zoo are celebrating the birth of a western lowland gorilla, but are yet to identify its gender.
Topics: animals, zoos, sydney-2000, mosman-2088
Topics: animals, zoos, adelaide-5000
Topics: zoos, endangered-and-protected-species, currumbin-4223, perth-6000
Posted| Updated
A two-month-old chimpanzee named Keeva has moved from Baltimore to Florida in search of a surrogate chimp mother after her birth mother was unable to care for her.
Topics: animals, zoos, surrogacy, united-states
Posted| Updated
A Japanese zoo rethinks its decision to name a baby monkey Charlotte following complaints it was disrespectful to Britain's newborn princess.
Topics: zoology, animal-science, zoos, royal-and-imperial-matters, offbeat, japan
Posted| Updated
There's a new addition at Mogo Zoo with the birth of an endangered silvery gibbon on the New South Wales far south coast.
Topics: animals, animals-and-nature, zoos, mogo-2536, bega-2550
Posted| Updated
Two male meerkats are set loose in an enclosure at a Darwin zoo, where they will attempt to woo a solitary female meerkat, after her previous companion passed away.
Topics: animals, zoos, darwin-0800
Posted| Updated
Six African painted dogs take up residence in the newest exhibit at Canberra's National Zoo, which has been recently opened to the public.
Topics: zoos, human-interest, animals, canberra-2600, act, sa
Two mice-like marsupials settle into their new home at a tourist centre in a small Queensland outback town.
Topics: animals, human-interest, zoos, julia-creek-4823
Keepers at Melbourne Zoo are "99 per cent sure" a baby western lowland gorilla born over the weekend is a girl as they prepare for the newborn's first public outing.
Topics: animals, zoology, zoos, endangered-and-protected-species, melbourne-3000
A baby gibbon hand-raised at Perth Zoo after his mother had trouble caring for him is now back with his family and doing well.
Topics: animals, zoos, animal-science, perth-6000
Posted| Updated
Kimya the western lowland gorilla gives birth at Melbourne Zoo, with the "momentous occasion" marking the first arrival for the species there in 15 years.
Topics: zoology, zoos, endangered-and-protected-species, melbourne-3000
Posted| Updated
Melbourne zoo keepers listen to the heartbeat of an unborn gorilla, in what is believed to be an Australian first, with mother-to-be Kimya experiencing the telltale signs of pregnancy, including "squishy feet".
Topics: zoos, animals, melbourne-3000
Posted| Updated
Zoos SA will introduce a "predator experience" with overnight safari-style accommodation as well as a gorillas exhibit and treetop monkey runs as part of its plans to transform Adelaide and Monarto zoos over the next 20 years.
Topics: zoos, animal-science, sa, adelaide-5000


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Apoptosis Apoptosis is also thought to play a role in the progression of many auto- immune diseases. For example, in the Phil Dash case of rheumatoid arthritis excessive Basic Medical Sciences, St.George's, University of London proliferation of synovial cells is thought www.sgul.ac.uk/dept/immunology/~dash to be due in part to the resistance of these cells to apoptotic stimuli. In other Apoptosis, or programmed cell death, is a in the case of cancer cells mutations may cases poor regulation of apoptosis in T- normal component of the development and have occurred that prevent cells from lymphocytes can result in auto-reactive health of multicellular organisms. Cells undergoing apoptosis. In these cases there T-cells entering the circulation and die in response to a variety of stimuli and is no check on the cellular proliferation contributing to the onset of autoimmune during apoptosis they do so in a controlled, and consequently the disease can progress diseases. regulated fashion. This makes apoptosis to the formation of tumors. In many cases distinct from another form of cell death these tumors can be difficult to kill as The apoptotic process called necrosis in which uncontrolled cell many cancer treatments rely on damaging death leads to lysis of cells, inflammatory the cells with radiation or chemicals and Upon receiving specific signals instructing responses and, potentially, to serious mutations in the apoptotic pathway often the cells to undergo apoptosis a number health problems. Apoptosis, by contrast, produce cells that are resistant to this type of distinctive changes occur in the cell. is a process in which cells play an active of attack. Understanding how apoptosis is A family of proteins known as caspases role in their own death (which is why regulated in cancer is therefore of major are typically activated in the early stages apoptosis is often referred to as cell interest in the development of treatments of apoptosis. These proteins breakdown suicide). for this disease. or cleave key cellular components that are required for normal cellular function Apoptosis in health and disease If cancer is a disease where too little including structural proteins in the apoptosis occurs there are other diseases cytoskeleton and nuclear proteins such as Apoptosis occurs during the normal where too much apoptosis is thought DNA repair enzymes. The caspases can development of multicellular organisms to be part of the problem. For example also activate other degradative enzymes and continues throughout adult life. in neurodegenerative diseases such as such as DNases, which begin to cleave The combination of apoptosis and cell Parkinson's or Alzheimer's Diseases the DNA in the nucleus. proliferation is responsible for shaping apoptosis is thought to account for much tissues and organs in developing embryos. of the cell death and the progressive loss Apoptotic cells display distinctive For example the apoptosis of cells located of neurons. morphology during the apoptotic process, in-between the toes allows for their and this can be seen in Figure 1. Typically, separation. Apoptosis is also important for normal the cell begins to shrink following the placental development. During pregnancy cleavage of lamins and actin filaments Apoptosis is also an important part of trophoblast cells from the placenta invade in the cytoskeleton (A). The breakdown the regulation of the immune system. the uterine environment in order to of chromatin in the nucleus often leads T lymphocytes are cells of the immune remodel the maternal blood vessels and to nuclear condensation and in many system that are responsible for destroying help establish and maintain a successful cases the nuclei of apoptotic cells take infected or damaged cells in the body. pregnancy. Strict control over cell on a "horse-shoe" like appearance (B). They mature in the thymus, but before proliferation and apoptosis is required to Cells continue to shrink (C), packaging they can enter the bloodstream they are achieve this. In some cases this process can themselves into a form that allows for tested to ensure that they are effective be compromised and excessive apoptosis their removal by macrophages. These against foreign antigens and are also not of the trophoblast cells is thought to be phagocytic cells are responsible for reactive against normal, healthy cells. implicated in the failure to fully remodel clearing the apoptotic cells from tissues Any ineffective or self-reactive T-cells the maternal environment that is observed in a clean and tidy fashion that avoids are removed through the induction of in complications of pregnancy such as many of the problems associated with apoptosis. preeclampsia. necrotic cell death. In order to promote Problems with the regulation of apoptosis have been implicated in a number of diseases. Cancer is a disease that is often characterized by too little apoptosis. Cancer cells typically possess a number of mutations that have allowed them to ignore normal cellular signals regulating their growth and become more proliferative Figure 1: Morphology of an apoptosic trophoblast cell as captured by time- than normal. Under normal circumstances lapse microscopy (images taken over a 6 hour period). damaged cells will undergo apoptosis, but 1 APOPTOSIS www.sgul.ac.uk/depts/immunology/~dash their phagocytosis by macrophages, alpha and TRAIL. They play an important associated death domain) via interactions apoptotic cells often ungergo plasma role in apoptosis and can activate a caspase between death domains. TRADD has the membrane changes that trigger the cascade within seconds of ligand binding. ability to recruit a number of different macrophage response. One such change Induction of apoptosis via this mechanism proteins to the activated receptor. is the translocation of phosphatidylserine is therefore very rapid. Recruitment of TRAF2 (TNF-associated from the inside of the cell to the outer factor 2) can lead to activation of NF-kB surface. The end stages of apoptosis are Apoptotic signalling from the death and the JNK pathway. TRADD can also often characterised by the appearance of receptors associate with FADD, which leads to the membrane blebs (D) or blisters process. induction of apoptosis via the recruitment Small vesicles called apoptotic bodies are Although there are differences in the and cleavage of pro-caspase 8. also sometimes observed (D, arrow). signalling pathways activated by the different death receptors it is possible There are a number of mechanisms to outline a general apoptotic signalling through which apoptosis can be induced pathway. Binding of the death inducing in cells. The sensitivity of cells to any ligand to its receptor can lead to a of these stimuli can vary depending on a the generation of ceramide, typically number of factors such as the expression produced by acid sphingomyelinase. This of pro- and anti-apoptotic proteins (eg. ceramide release is thought to promote the Bcl-2 proteins or the Inhibitor of lipid raft fusion which results in a large Apoptosis Proteins), the severity of the scale clustering of the death receptors. stimulus and the stage of the cell cycle. The large scale receptor clustering is Some of the major stimuli that can induce important because it helps amplify the apoptosis include virus infection, cell apoptotic signalling. In the absence of stress and DNA damage. receptor clustering some cells, such as lymphocytes, are still able to trigger In some cases the apoptotic stimuli apoptosis but in most cases amplification comprise extrinsic signals such as the of the signalling pathway is needed to binding of death inducing ligands to cell activate the full apoptotic response. surface receptors called death receptors. Following ligand binding a conformational These ligands can either be soluble change in the intracellular domains of the factors or can be expressed on the surface receptors reveals the presence of a "death of cells such as cytotoxic T lymphocytes. domain" which allows the recruitment of The latter occurs when T-cells recognise various apoptotic proteins to the receptor. damaged or virus infected cells and This protein complex is often called the initiate apoptosis in order to prevent DISC, or Death Inducing Signalling damaged cells from becoming neoplastic Complex. The final step in this process (cancerous) or virus-infected cells from is the recruitment of one of the caspases, Figure 2: Illustration of the main TNF spreading the infection. Apoptosis can also typically caspase 8, to the DISC. This receptor signalling pathways. be induced by cytotoxic T-lymphocytes results in activation of caspase 8 and the using the enzyme granzyme. inititation of apoptosis. Signaling by Fas (CD95) In other cases apoptosis can be initiated TNF receptor signalling following intrinsic signals that are The ligand for Fas (FasL or CD95L) produced following cellular stress. TNF is produced by T-cells and activated activated apoptosis in a similar way to Cellular stress may occur from exposure macrophages in response to infection. the TNF receptor. Binding of the ligand to radiation or chemicals or to viral By activating its receptor, TNFR1, TNF promotes receptor clustering, DISC infection. It might also be a consequence can have several effects (see Figure 2). formation and the activation of the caspase of growth factor deprivation or oxidative In some cells it leads to activation of NF- cascade. However, signalling through stress caused by free radicals. In general kB and AP-1 which leads to the induction the Fas receptor is slightly simpler than intrinsic signals initiate apoptosis via the of a wide range of genes. In some cells, through the TNF receptor. The adapter involvement of the mitochondria. The however, TNF can also induce apoptosis, protein FADD can be recruited directly relative ratios of the various bcl-2 proteins although receptor ligation is rarely enough to the death domain on the Fas receptor, can often determine how much cellular on its own to initiate apoptosis as is the without requiring the prior recruitment stress is necessary to induce apoptosis. case with Fas ligand binding. of TRADD. In addition the Fas receptor is generally though to only activate Death Receptors Binding of TNF alpha to TNFR1 results apoptosis and does not play an important in receptor trimerisation and clustering role in other aspects of cell signalling like Death receptors are cell surface receptors of intracellular death domains. This the TNF receptor. that transmit apoptotic signals initiated by allows binding of an intracellular adapter specific ligands such as Fas ligand, TNF molecule called TRADD (TNFR- 2 APOPTOSIS www.sgul.ac.uk/depts/immunology/~dash Induction of apoptosis by TRAIL be important in the formation of the PT The role of mitochondria in the induction pore. of apoptosis is summarised in Figure 3. In a number of ways TRAIL (TNF-related apoptosis inducing ligand) is similar The pro-apoptotic bcl-2 proteins are Caspases and apoptosis in action to FasL. Binding of TRAIL to often found in the cytosol where they act its receptors DR4 or DR5 triggers rapid as sensors of cellular damage or stress. The caspases are a family of proteins apoptosis in many cells. Interestingly there Following cellular stress they relocate that are one of the main executors of the are also decoy receptors that compete for to the surface of the mitochondria where apoptotic process. They belong to a group binding of TRAIL with the DR4 and DR5 the anti-apoptotic proteins are located. of enzymes known as cysteine proteases receptors. The decoy receptors are called This interaction between pro- and anti- and exist within the cell as inactive pro- DcR1 and DcR2. Both of these receptors apoptotic proteins disrupts the normal forms or zymogens. These zymogens are capable of competing with DR4 or function of the anti-apoptotic bcl-2 can be cleaved to form active enzymes DR5 receptors for binding to the ligand proteins and can lead to the formation of following the induction of apoptosis. (TRAIL), however ligation of these pores in the mitochondria and the release receptors does not initiate apoptosis since of cytochrome C and other pro-apoptotic Induction of apoptosis via death receptors DcR1 does not possess a cytoplasmic molecules from the intermembrane space. typically results in the activation of an domain, while DcR2 has a truncated death This in turn leads to the formation of the initiator caspase such as caspase 8 or domain lacking 4 out of 6 amino acids apoptosome and the activation of the caspase 10. These caspases can then essential for recruiting adapter proteins. caspase cascade. activate other caspases in a cascade. This cascade eventually leads to the activation Role of mitochondria in apoptosis The release of cytochrome C from the of the effector caspases, such as caspase mitochondria is a particularly important 3 and caspase 6. These caspases are Mitochondria play an important role in event in the induction of apoptosis. Once responsible for the cleavage of the key the regulation of cell death. They contain cytochrome C has been released into cellular proteins, such as cytoskeletal many pro-apoptotic proteins such as the cytosol it is able to interact with a proteins, that leads to the typical Apoptosis Inducing Factor (AIF), Smac/ protein called Apaf-1. This leads to the morphological changes observed in cells DIABLO and cytochrome C. These recruitment of pro-caspase 9 into a multi- undergoing apoptosis. factors are released from the mitochondria protein complex with cytochrome C and following the formation of a pore in Apaf-1 called the apoptosome. Formation the mitochondrial membrane called the of the apoptosome leads to activation of Permeability Transition pore, or PT pore. caspase 9 and the induction of apoptosis. These pores are thought to form through the action of the pro-apoptotic members of the bcl-2 family of proteins, which in turn are activated by apoptotic signals such as cell stress, free radical damage or growth factor deprivation. Mitochondria also play an important role in amplifying the apoptotic signalling from the death receptors, with receptor recruited caspase 8 activating the pro-apoptotic bcl-2 protein, Bid. Role of Bcl-2 proteins The bcl-2 proteins are a family of proteins involved in the response to apoptosis. Some of these proteins (such as bcl-2 and bcl-XL) are anti-apoptotic, while others (such as Bad, Bax or Bid) are pro-apoptotic. The sensitivity of cells to apoptotic stimuli can depend on the balance of pro- and anti-apoptotic bcl- 2 proteins. When there is an excess of pro-apoptotic proteins the cells are more sensitive to apoptosis, when there is an excess of anti-apoptotic proteins the cells will tend to be more resistant. An excess of pro-apoptotic bcl-2 proteins at the Figure 3: Illustration of the main apoptotic signalling surface of the mitochondria is thought to pathways involving mitochondria 3 APOPTOSIS www.sgul.ac.uk/depts/immunology/~dash The apoptosome 1) Inactivation of enzymes involved in immune function. Nitric oxide has also DNA repair. been demonstrated to be involved in the There are a number of other mechanisms, regulation of apoptosis. aside from activation of the death receptors, The enzyme poly (ADP-ribose) through which the caspase cascade can be polymerase, or PARP, is an important The effects of apoptosis vary depending activated. Granzyme B can be delivered DNA repair enzyme and was one of the upon the dose of NO and the type of into cells by cytotoxic T lymphocytes and first proteins identified as a substrate for cell used and has been shown to be able is able to directly activate caspases 3, 7, caspases. The ability of PARP to repair to both induce apoptosis and to protect 8 and 10. The mitochondria are also key DNA damage is prevented following from apoptosis in different cell types. regulators of the caspase cascade and cleavage of PARP by caspase-3. Nitric oxide has been demonstrated to apoptosis. Release of cytochrome C from inhibit apoptosis in a number of cell mitochondria can lead to the activation 2) Breakdown of structural nuclear types including leukocytes, hepatocytes, of caspase 9, and then of caspase 3. This proteins. trophoblasts and endothelial cells. effect is mediated through the formation of Generally the anti-apoptotic effects of an apoptosome, a multi-protein complex Lamins are intra-nuclear proteins that NO can be mediated through a number consisting of cytochrome C, Apaf-1, pro- maintain the shape of the nucleus and of mechanisms such as the nitrosylation caspase 9 and ATP. The formation of the mediate interactions between chromatin and inactivation of many of the caspases apoptosome is illustrated in Figure 4. and the nuclear membrane. Degradation including caspase 3, caspase 1 and caspase of lamins by caspase 6 results in the 8. Other mechanisms include activating chromatin condensation and nuclear p53, upregulating heat shock protein 70 fragmentation. (and consequently blocking recruitment of pro-caspase 9 to the Apaf-1 apoptosome), 3) Fragmentation of DNA. upregulating Bcl-2 and Bcl-XL (with subsequent inhibition of cytochrome The fragmentation of DNA into C release from the mitochondria) and nucleosomal units is caused by an enzyme activating cGMP signaling leading to known as CAD, or caspase activated activation of cGMP-dependent protein DNase. Normally CAD exists as an kinases and suppression of caspase inactive complex with ICAD (inhibitor of activity. CAD). During apoptosis, ICAD is cleaved by caspases, such as caspase 3, to release The effects of NO on apoptosis are CAD. Rapid fragmentation of the nuclear generally classified as cGMP dependent DNA follows. or independent. Nitric oxide is able to activate cGMP signaling through the Role of Nitric Oxide in Apoptosis interaction of NO with the haem group of guanylate cyclase. The production of Nitric oxide (NO) is an important signaling cGMP leads to the activation of cGMP- molecule that acts in many tissues to dependent protein kinases and possibly regulate a diverse range of physiological to increased expression of anti-apoptotic processes including vasodilation, proteins. neuronal function, inflammation and Figure 4: Formation of the apoptosome Caspases and chromatin breakdown One of the hallmarks of apoptosis is the cleavage of chromosomal DNA into nucleosomal units. The caspases play an important role in this process by activating DNases, inhibiting DNA repair enzymes and breaking down structural proteins in the nucleus. The role of the caspases in the breakdown of chromatin is illustrated in Figure 5. Figure 5: Breakdown of chromatin during apoptosis 4 APOPTOSIS www.sgul.ac.uk/depts/immunology/~dash Further Reading Death Differ 10, 864-9 (2003). cell line SGHPL-4. Human 13. Brune, B., von Knethen, A. & Reproduction 18, 959-968 Sandau, K. B. Nitric oxide and (2003). 1. Adams, J. M. & Cory, S. its role in apoptosis. European 24. Dash, P. R., Whitley, G. S., Life-or-death decisions by the Journal of Pharmacology 351, Ayling, L. J., Johnstone, A. Bcl-2 protein family. Trends in 261-272 (1998). P. & Cartwright, J. E. Tropho- Biochemical Sciences 26, 61-6 14. Brune, B., von Knethen, A. blast apoptosis is inhibited (2001). & Sandau, K. B. Nitric oxide by hepatocyte growth factor 2. Ahern, G. P., Klyachko, V. A. (NO): an effector of apoptosis. through the Akt and beta- & Jackson, M. B. cGMP and Cell Death and Differentiation catenin mediated up-regulation S-nitrosylation: two routes for 6, 969-975 (1999). of inducible nitric oxide syn- modulation of neuronal excitabil- 15. Budihardjo, I., Oliver, H., thase. Cellular Signalling 17, ity by NO. Trends Neurosci 25, Lutter, M., Luo, X. & Wang, 571-80 (2005). 510-7 (2002). X. Biochemical pathways 25. Datta, S. R. et al. Akt 3. Algeciras-Schimnich, A. et al. of caspase activation during phosphorylation of BAD Molecular ordering of the initial apoptosis. Annu Rev Cell Dev couples survival signals to the signaling events of CD95. Mol Biol 15, 269-90 (1999). cell-intrinsic death machinery. Cell Biol 22, 207-20 (2002). 16. Cardone, M. H. et al. Regula- Cell 91, 231-241 (1997). 4. Allaire, A. D., Ballenger, K. tion of cell death protease 26. Downward, J. How BAD phos- A., Wells, S. R., McMahon, M. caspase-9 by phosphorylation. phorylation is good for survival. J. & Lessey, B. A. Placental Science 282, 1318-1321 (1998). Nature Cell Biology 1, E33-E35 apoptosis in preeclampsia. 17. Carey, G. B. et al. B-cell recep- (1999). Obstetrics and Gynecology 96, tor and Fas-mediated signals 27. Engelmann, I. & Bauer, G. 271-276 (2000). for life and death. Immunol Rev How can tumor cells escape 5. Ashkenazi, A. & Dixit, V. M. 176, 105-15 (2000). intercellular induction of apop- Apoptosis control by death 18. Chang, D. W. et al. c-FLIP(L) tosis? Anticancer Research 20, and decoy receptors. Current is a dual function regulator for 2297-2306 (2000). Opinion in Cell Biology 11, caspase-8 activation and CD95- 28. Engels, I. H., Totzke, G., 255-60 (1999). mediated apoptosis. Embo J 21, Fischer, U., Schulze-Osthoff, 6. Barnhart, B. C., Alappat, E. C. 3704-14 (2002). K. & Janicke, R. U. Caspase- & Peter, M. E. The CD95 type 19. Chen, M. & Wang, J. Initiator 10 sensitizes breast carcinoma I/type II model. Semin Immunol caspases in apoptosis signaling cells to TRAIL-induced but not 15, 185-93 (2003). pathways. Apoptosis 7, 313-9 tumor necrosis factor-induced 7. Bedi, A. On the TRAIL from (2002). apoptosis in a caspase-3- death receptors to prostate 20. Chou, J. J., Matsuo, H., Duan, dependent manner. Mol Cell cancer therapy. Cancer Biol H. & Wagner, G. Solution Biol 25, 2808-18 (2005). Ther 1, 638-9 (2002). structure of the RAIDD CARD 29. Eramo, A. et al. CD95 death- 8. Beere, H. et al. Heat-shock and model for CARD/CARD inducing signaling complex protein 70 inhibits apoptosis interaction in caspase-2 and formation and internalization by preventing recruitment caspase-9 recruitment. Cell 94, occur in lipid rafts of type I and of procaspase-9 to the Apaf- 171-180 (1998). type II cells. Eur J Immunol 34, 1 apoptosome. Nature Cell 21. Curtin, J. F. & Cotter, T. G. 1930-40 (2004). Biology 2, 469-475 (2000). Live and let die: regulatory 30. Garofalo, T. et al. Association 9. Belka, C. et al. Differential role mechanisms in Fas-mediated of the death-inducing signaling of caspase-8 and BID activation apoptosis. Cell Signal 15, 983- complex with microdomains during radiation- and CD95- 92 (2003). after triggering through CD95/ induced apoptosis. Oncogene 22. Dash, P. R., Cartwright, J. E., Fas. Evidence for caspase-8- 19, 1181-1190 (2000). Baker, P. N., Johnstone, A. P. ganglioside interaction in T 10. Benhar, M. & Stamler, J. S. A & Whitley, G. S. Nitric oxide cells. J Biol Chem 278, 8309-15 central role for S-nitrosylation protects human extravillous (2003). in apoptosis. Nat Cell Biol 7, trophoblast cells from apoptosis 31. Guo, F. & Bhalla, K. The FLIP 645-6 (2005). by a cyclic GMP-dependent variation on the TRAIL DISC: 11. Blanchard, H. et al. The mechanism and independently doxorubicin conducts the swan three-dimensional structure of of caspase 3 nitrosylation. Exp song. Cancer Biol Ther 1, 528-9 caspase-8: an initiator enzyme Cell Res 287, 314-24 (2003). (2002). in apoptosis. Structure with 23. Dash, P. R., Cartwright, J. Folding & Design 7, 1125-1133 E. & Whitely, G. S. Nitric (1999). oxide inhibits polyamine- 12. Brune, B. Nitric oxide: NO induced apoptosis in the apoptosis or turning it ON? Cell human extravillous trophoblast 5 APOPTOSIS www.sgul.ac.uk/depts/immunology/~dash 32. Grassme, H., Cremesti, A., inducing signaling complexin Kolesnick, R. & Gulbins, E. lymphocytes. J Clin Immunol Ceramide-mediated clustering 23, 333-53 (2003). is required for CD95-DISC 43. Weber, C. H. & Vincenz, formation. Oncogene 22, 5457- C. A docking model of key 70 (2003). components of the DISC 33. Hennino, A., Berard, M., complex: death domain Casamayor-Palleja, M., superfamily interactions Krammer, P. H. & Defrance, edefined. FEBS Lett 492, 171-6 T. Regulation of the Fas death (2001). pathway by FLICE-inhibitory 44. LaCasse, E. C., Baird, S., protein in primary human B Korneluk,R. G. & MacKenzie, cells. J Immunol 165, 3023-30 A. E. The inhibitors of apoptosis (2000). (IAPs) and their emerging role 34. Krueger, A., Schmitz, I., in cancer. Oncogene 17, 3247- Baumann, S., Krammer, P. 59 (1998). H. & Kirchhoff, S. Cellular 45. Mahajan, N. P. et al. Bcl- FLICE-inhibitory protein splice 2 and Bax interactions in variants inhibit different steps mitochondria probed with of caspase-8 activation at the green fluorescent protein and CD95 death-inducing signaling fluorescence resonance energy complex. J Biol Chem 276, transfer. Nature Biotechnology 20633-40 (2001). 16, 547-552 (1998). 35. Kruidering, M. & Evan, G. 46. Medema, J. P., Scaffidi, C., I. Caspase-8 in apoptosis: Krammer, P. H. & Peter, M. The beginning of "The End"? E. Bcl-xL acts downstream IUBMB LIFE USA 50, 85-90 of caspase-8 activation by the (2000). CD95 death-inducing signaling 36. Lloyd, A. Caspase-8: an initiator complex. J Biol Chem 273, of Fas-mediated apoptosis. Drug 3388-93 (1998). Discovery Today 3, 525-525 47. Nuessler, V. et al. Bcl-2, bax (1998). and bcl-xL expression in human 37. Medema, J. P. et al. FLICE is sensitive and resistant leukemia activated by association with the cell lines. Leukemia 13, 1864- CD95 death-inducing signaling 1872 (1999). complex (DISC). Embo J 16, 48. O'Connor, L., Huang, D. C., 2794-804 (1997). O'Reilly, L. A. & Strasser, A. 38. Ozoren, N. & El-Deiry, W. Apoptosis and cell division. S. Defining characteristics of Current Opinion in Cell Biology Types I and II apoptotic cells in 12, 257-63 (2000). response to TRAIL. Neoplasia 49. Sawada, N. et al. Ordering of 4, 551-7 (2002). ceramide formation, caspase 39. Scaffidi, C. et al. Two CD95 activation, and Bax/Bcl-2 (APO-1/Fas) signaling expression during etoposide- pathways. Embo J 17, 1675-87 induced apoptosis in C6 (1998). glioma cells. Cell Death and 40. Sprick, M. R. et al. FADD/ Differentiation 7, 761-772 MORT1 and caspase-8 are (2000). recruited to TRAIL receptors 50. Stennicke, H. R. et al. Pro- 1 and 2 and are essential for caspase-3 is a major physiologic apoptosis mediated by TRAIL target of caspase-8. J.Biol. receptor 2. Immunity 12, 599- Chem. 273, 27084-27090 609 (2000). (1998). 41. Srivastava, R. K. TRAIL/ 51. Tan, Y., Demeter, M. R., Ruan, Apo-2L: mechanisms and H. & Comb, M. J. BAD Ser-155 clinical applications in cancer. phosphorylation regulates BAD/ Neoplasia 3, 535-46 (2001). Bcl-XL interaction and cell 42. Walsh, C. M., Luhrs, K. survival. Journal of Biological A. & Arechiga, A. F. The Chemistry 275, 25865-25869 "fuzzy logic" of the death- (2000). 6
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text: Hotel was very good. 2 pools.lounge/pool bar and kitchen. English t.v. amusement park opp. Drinks 2 for 1. 2x English bars next door. Very close to shops and supermarkets and 5 mins from the beach. Unfortunately I had some young clubbers above me who were very noisy at different times of day and night. Staff did sort out next day... More


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Breakfast with the Easter Bunny
Various venues
Until Sun Mar 24 2013
- $$
Photograph: Courtesy Aviator Sports
Not yet rated
Time Out says
Mon Apr 11 2011
Skip your usual Sunday brunch routine in favor of this festive feast, where families chow down with the Easter Bunny at a buffet and then pose for pictures with the larger-than-life rabbit. The celebration continues through the afternoon with an egg hunt, arts and crafts, cupcake decorating and candy bags. Reservations required; must RSVP by March 18. All ages.
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Product description: 'Vanya is the most important soldier in the regiment. Vanya is a Dragon Rider. Only women can tame dragons because only women can connect with the beasts on an instinctive level; by mating with them, the women gain control over the dragon. But when Vanya's commander orders her into the sky, she enters a world where her dragon is in control. The dragon plucks Vanya from her saddle, intent on teaching her who rules the skies, whether she likes it or not.'
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Details and Shopping
Customer Favorite
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Oversized boxy long-sleeve tee with cool cutout detailing on the back. Dolman sleeves that create a cool caplet shape.
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Measurements for One Size:Length: 21"
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Sleeve Length: 26 1/2"
Rated 4.3 out of 5Â by 48 reviewers.
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Rated 5 out of 5Â by kryn dress up or dress down! For sizing, it is loose, but I wouldn't say it runs "large". It's hard to say since it's a one size shirt, but It really is a perfect baggy/flowy shirt which can be worn with a pair of leggings and boots for the day, or dressed up with heels. The detailing on the back is awesome and really makes it stand out. The front is shorter than the back, as well as the sides, so your belly can show a bit if you throw your arms up because the shirt is flowy, but nothing too crazy...great buy! 3.10.2013
Rated 5 out of 5Â by tanfox #'s 2 & 3 are on their way! I am so excited that the others are on their way, I created an account just to write this review! I bought the ivory one as it was in store as a return... I was looking for things to wear on my babymoon to Antigua... I love this top more than anything... I got home from my trip wanting the black and grey and they only just came into stock. I am glad that I will have grey and black because I am so afraid to ruin the light one. It is one of my very favorite tops. Soft soft soft! I am tall, 5'9'' and I think it's good to have height to pull off so it doesn't look like a blob. I have been 6-8 months prego when wearing and my height has helped pull off the top with my big bump! I will be wearing this home from the hospital with my little one in a couple weeks... I will feel comfortable and cute! -ENJOY! 2.20.2013
Rated 5 out of 5Â by lynard Love it! I adore this shirt. Everytime I wear it I get compliments. It fits true to size and it's just adorable. It is now my new favorite. It also washed really well. I'm 5'4" and the length is perfect. 1.23.2013
Rated 5 out of 5Â by Maga Surprisingly Sexy! As a petite woman, it is hard to work the oversized look. I also have the issue of large bust/small waist/curvy hips to take into consideration- my hourglass shape looks awesome in fitted tops, but oversized pieces tend to scream "maternity shirt!" This little beauty, however, looks PERFECT on me! It drapes beautifully and highlights some of the features that are... ahem.... "overshadowed" by my chest, shall we say? LOVE the cutouts on the back, love the neckline, love the sleeves. I'm rocking this with a pair of leather shorts, tights, and boots for a boho rock look; or with a long black skirt and a cami for work. Either look gets me tons of compliments. 1.22.2013
Rated 4 out of 5Â by katieh Like, But Not Love I usually wear a large, so when it comes to "one size fits all" I tend to be a little skeptical. This did fit and looked cute, but it did not fit me like it did the model. The length in front was much shorter than I would like. It fell just past the waist of my pants as opposed to hip level like it is on the model. The length in back was nice but again shorter than I would have liked. The fabric is soft, the drape is beautiful, and the comfort is outstanding. I was hoping for a fit like the Big Dipper Over-sized Tee, but this was not quite there. This is a great top for all year. 1.16.2013
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Latest News
Project Inform has published a new informative treatment guide for patients who have been recently been diagnosed with Hepatitis C. As the options for treating hepatitis C (HCV) are increasing, so is the confusion. This is a good problem to have: with more treatment options come more opportunities for people with various HCV genotypes (GT), treatment history and varying levels of cirrhosis to get cured. For more information visit: http://www.projectinform.org/hepc/i-have-hepatitis-c-what-are-my-treatment-options/
Pangaea's Inaugural Global Health Leadership Dinner 12th May 2015.
Three hundred supporters joined Pangaea for our inaugural Global Health Leadership Dinner on May 12th in Oakland, California. As well as reinforcing the importance of keeping public attention focused on the global response to AIDS, supporters learned more about the important work we do to support countries around the world in their fight against HIV.
Photographs from the evening are available at http://drewaltizer.com/events/5739/pangaea-global-health-leadership-dinner-at-rotunda/album/top-picks/
The theme of the evening was Africa's dynamism and creativity, which was reflected in the entertainment provided by Berkeley-based Zimbabwean song and dance troupe, Chinyakare, and venue décor provided by Arts Africans.
We honored four extraordinary local and global heroes who have made a significant difference, saving lives and preventing new HIV infections around the world:
- Dr Peter Piot, Director, London School of Hygiene and Tropical Medicine, and Founding Executive Director of UNAIDS
- Dr Huma Abbasi, General Manager of Global Health and Medical, Global Health Champion, Chevron
- Dr Tsi Tsi Appollo, Deputy Director, HIV and TB Program, Ministry of Health and Child Welfare, Zimbabwe
- Miss Gloria Lockett, Executive Director, California Prostitutes Education Project (CALPEP)
In addition, Pangaea's CEO, Ben Plumley announced two new major initiatives:
- Helping vulnerable LGBTI communities, in countries with strong anti-gay laws and practices, access HIV related services through networks of supportive healthcare professionals. Pangaea will collaborate with the Global Forum on MSM and HIV/AIDS, www.msmgf.org, on this initiative.
- Identifying research and program delivery gaps in Pre Exposure Prophylaxis (PREP) for girls and women in the Global South.
For more information about how you can support Pangaea's mission, please visit http://pangaeaglobal.org/how-you-can-help/donate. You may wish to become a regular contributor, or make a single contribution that is meaningful to you; every cent matters and without your help, we could not support innovative, effective AIDS responses in Africa, Asia, and here at home in Oakland.
In the meantime, Pangaea proudly thanks our honorees, sponsors and supporters for making the evening such a memorable event, with a shared commitment made by all to speak out and loudly about the need for a continued strong global response to AIDS!
This World AIDS Day is a promising one with several new HIV prevention interventions for young women on the horizon.
It is in Zimbabwe's best interest to prepare for these emerging strategies now. Just last year, HIV prevalence among pregnant women aged 15-24 in Zimbabwe was a startling 10.4 percent. This number is indicative of a larger trend in southern Africa where adolescent women are up to eight times more likely to become infected with HIV than young men.
Young women's high rates of HIV are due in part to biological, social and economic factors making them more susceptible. Because efforts to promote abstinence, monogamy and the use of male condoms have not been enough to stop HIV among girls and young women, researchers have been working to develop women-initiated biomedical prevention interventions. Years of scientific exploration here in Zimbabwe and around the world are finally starting to pay off. PrEP (pre-exposure prophylaxis), microbicide gels and rings are three methods that could potentially turn around the endemic rates of HIV in young women.
Recommendation on Integrase Inhibitor Use in Antiretroviral Treatment-Naive HIV-Infected Individuals from the HHS Panel on Antiretroviral Guidelines for Adults and Adolescents
In the February 12, 2013, version of the Health and Human Services (HHS) Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents, the Panel recommendations on initial combination regimens for the antiretroviral therapy (ART)-naive, HIV-infected patient include raltegravir (RAL) plus tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as the preferred integrase strand transfer inhibitor (INSTI)-based regimen, and elvitegravir (EVG)/cobicistat (cobi)/TDF/FTC as an alternative regimen for patients with estimated creatinine clearance (CrCl) ≥70 mL/min. Since the release of the Guidelines, a new INSTI, dolutegravir (DTG), was approved for use in ART-naive and ART-experienced patients. Additionally, long-term follow-up data (up to 144 weeks) from randomized clinical trials have demonstrated the durable safety and efficacy of EVG/cobi/TDF/FTC.
On the basis of these new findings, the Panel now recommends the following 4 INSTI-based regimens as preferred regimens for ART-naive patients (arranged in order of drug approval):
On 30th October 2013, Medecin Sans Frontieres launched a variety of new reports and advocacy tools at the Union Conference, including the DR-TB Drugs Under the Microscope, 3rd Edition report, and the "Test Me, Treat Me" TB Manifesto. You can find the press release by clicking here
The DR-TB Drugs Under the Microscope report aims to provide information on the prices, sources, access environment and R&D landscape for DR-TB medicines. It includes an analysis of the progress being made globally for the development of life-saving medicines for TB patients as well as the many remaining challenges. The report is available for download on our website, here.


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Ranch home in immaculate condition located on a private wooded lot. Open great room with bay/bow window and vaulted/beamed ceiling. Large brick hearth fireplace. New carpet throughout. Eat-in kitchen and separate dining room. Master bedroom suite with walk-in closet. French doors leads to private fenced yard with mature trees. Large custom mini barn with power. All Appliances included. Home Warranty provided by seller.


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After a program has been thrown into the world in binary form, it can boomerang back as source code. The Boomerang reverse engineering framework is the first general native executable decompiler available to the public.1,841 weekly downloads
The Sleuth Kit
The Sleuth Kit is a C++ library and collection of open source file system forensics tools that allow you to, among other things, view allocated and deleted data from NTFS, FAT, FFS, EXT2, Ext3, HFS+, and ISO9660 images.744 weekly downloads
dlib C++ Library
Dlib is a C++ toolkit containing machine learning algorithms and tools for creating complex software in C++ to solve real world problems.787 weekly downloads
Cscope is a text screen based source browser652 weekly downloads
Dos2Unix / Unix2Dos - Text file format converters574 weekly downloads
A BibTeX replacement for users of biblatex, with full Unicode support543 weekly downloads
Audio and video streams generator661 weekly downloads
Enhanced CTorrent
Enhanced CTorrent is a BitTorrent client for unix-like environments. High performance with minimal system resources and dependencies is a priority.365 weekly downloads
owfs and owhttpd
Easy way to use the 1-wire sensors like temperature, voltage and more.281 weekly downloads
APBS is a software package for the numerical solution of the Poisson-Boltzmann equation, a popular continuum model for describing electrostatic interactions between molecular solutes over a wide range of length scales. <http://www.poissonboltzmann.org/>. Please register at http://goo.gl/LGVU5j before downloading!191 weekly downloads
GraphicsMagick provides a set of commandline tools and programming APIs for manipulating, editing, and converting raster and vector images. It is derived from ImageMagick, with the objective of providing better stability and performance than ImageMagick.1,051 weekly downloads
Virtual PC Simulator
VPCS600 weekly downloads
MiXiM is a simulator for wireless and mobile networks using the OMNeT++ simulation engine.209 weekly downloads
Implementation of GlobalPlatform smart card specification186 weekly downloads
Bit-Twist (Packet Generator)
Libpcap-based Ethernet packet generator for Mac OS X, Linux & Windows185 weekly downloads
Moscrack is a perl application designed to facilitate cracking WPA keys on a cluster of computers. This is accomplished with any one of Mosix clustering software, ssh, rsh or Pyrit connectivity to nodes. Cluster nodes can run any Un*x variant (includ231 weekly downloads
Tools for flashing Rockchip devices128 weekly downloads
DAR - Disk ARchive
For full, incremental, compressed and encrypted backups or archives113 weekly downloads
BCU SDK with eibd
BCU SDK is a C based, high level development system for creating programs for EIB/KNX BCU devices. It includes the GNU toolchain for the m68hc05 architecture (m68hc05-gcc, m68hc05-gdb, newlib). Bus access is possible using multiple methods.83 weekly downloads
JSBSim Flight Dynamics Model
JSBSim is an object-oriented (C++), multi-platform, 6-DOF, Flight Dynamics Model (FDM). It can be run as a standalone, batch-mode flight simulator (no graphical displays), or integrated with FlightGear or other flight simulator. The aircraft models included in this project and distribution do not include any proprietary, sensitive, or classified data. This should be rather obvious. All data is derived from textbooks, freely available technical reports, or other public data. Likewise, no proprietary code is included. All code included within JSBSim has been developed on a volunteer basis using publicly available information, and is often directly linked to a particular textbook, for educational reference.96 weekly downloads
open source production planning208 weekly downloads


text:
The best news in mobile marketing every Thursday.
There's No SEO Without Mobile SEO
It's 2014, which means we are officially one year away from the year that Kelsey Group predicted mobile search will eclipse desktop search. Are you making your mobile resolutions to ensure you're ready for when that time comes?
I'd like to start the new year with a short reflection of how far mobile SEO as a discipline has come in less than five years.
When I started researching mobile SEO back in 2005, Motorola Razr was the preferred handset, and most of the advice that was given was to validate your XHTML code in order to provide a better user experience for the majority of people in the hopes that Google would reward the webmaster's efforts in search results. My how things have changed in such a short time.
For more of my views on the progression of mobile SEO, check out my full column on Marketing Land.
Some opinions expressed in this article may be those of a guest author and not necessarily Search Engine Land. Staff authors are listed here.
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