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While Google made no official announcement, its Android One website now boasts that each new device "runs the latest and fastest version of Android," 5.1 Lollipop.
With an efficient diesel engine and an extendable bed, the Santa Cruz aims to be a compact pickup for millennials who don't want or need a truck.
Nonprofit Feeding Forward hits a global chord with its on-demand food-donating service.
The loudest protest so far against smartphone-era car services involves burning tires, blocked traffic, riot police and an assault on a celebrity taking an Uber ride from the airport.
Car company Lexus is working on a hoverboard, teasing the product with a short video showing off its prototype that flies using magnetic levitation.
Lengthy download times have been reported by European users.
An unexpected announcement in the Bethesda E3 showcase: The developer unveiled its first ever Fallout mobile game.
A scientist examining frog samples found an unexpected surprise in one of the frogs: another frog.
Sony will be steadily rolling out online access, following launch.
Check out all of Ubisoft's news from the greatest gaming show on Earth, streaming live -- expect Assassin's Creed and The Division to feature.


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Unlike the block towers kids usually build, the goal of this set is to keep it standing as long as possible. Just stack it up, roll the dice, then pull blocks out one by one without knocking the tower over.
Details, details
- Helps develop hand-eye coordination
- 60 piece set includes 2 dice for taking turns
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Show 'em what you're made of
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Kingsport Times News
Rogersville youth theater group presents 'Cinderella KIDS'
Kingsport Times News
Rogersville Arts Council recently announced its 2015 Broadway KIDS Theatre Arts Camp production of Disney's Cinderella KIDS. This production Cinderella features beloved songs such as "A Dream Is a Wish Your Heart Makes" and "Bibbidi Bobbidi Boo" ...
Rogersville Playhouse prepares for Broadway KIDS Theatre Arts Camp
ROGERSVILLE—The Rogersville Arts Council has announced that its 2015 Broadway KIDS Theatre Arts Camp production will be Disney's Cinderella KIDS. A timeless fairytale, Disney's Cinderella KIDS becomes a new audience favorite in this adaptation of ...
and more »
NPC Children's Theatre Project presenting 'Cinderella Kids' musical June 18-19
White Mountain Independent
SNOWFLAKE — Northland Pioneer College's Children's Theatre Project will presents three free performances of Disney's "Cinderella Kids" at 12 p.m. Thursday, June 18, and from 12-6 p.m. Friday, June 19, at the NPC Performing Arts Center on the Snowflake ...
Theater presents musical version of 'Cinderella'
Experience enchantment and magic as the Fort Bend Theatre presents "Disney's Cinderella Kids" now through June 28 on Saturdays and Sundays at 3 p.m. Tickets are $10 to the musical version of the timeless fairy tale. The theater is located at 2815 N ...
SLT to present Disney Cinderella KIDS
Shreveport Times
Tickets are now on sale for Disney's Cinderella KIDS, produced by Shreveport Little Theatre Academy. The timeless fairy tale becomes a new audience favorite in Disney's Cinderella KIDS, an adaptation of the treasured animated film. Disney's "rags to ...
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Letters from a Stoic (Penguin Classics) (edition 1969)
by Seneca
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Letters from a Stoic by Seneca
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Series of letters from an ageing Stoic philosopher, writing in 64AD on topics from travel to disease to death. Enjoyable stuff, I'm fond of the Stoics as a rare variety of philosopher I find useful as well as interesting, although my engagement did vary from letter to letter. No Marcus Aurelius, but one I would return to.
Brilliant. I love letters because they provide such an authentic voice which the historian cannot provide. I love the indignance of Seneca when he is staying above the bath house in Pompeii and telling his student about the massage parlour downstairs. Oh the horror!!
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The power and wealth which Seneca the Younger (C.4 B.C.- A.D. 65) acquired as Nero's minister were in conflict with his Stoic beliefs. Nevertheless he was the outstanding figure of his age. The Stoic philosophy which Seneca professed in his writings, later supported by Marcus Aurelius, provided Rome with a passable bridge to Christianity. Seneca's major contribution to Stoicism was to spiritualize and humanize a system which could appear cold and unrealistic.… (more)
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Multiple Mares 2 years to 10 years of age AMHA / AMHR These pretty mares have been a asset to our farm, consistently producing quality foals. All…$1,000
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This Show pony/ small Horse will be good for Barrels or Jumping . I have practiced Jumping with her. But i also have done a fun show/barrel race with her…$2,000
Very gentle tri-color Rocky Mountain/ Missouri Fox Trotter. This mare is the calmest horse I have ever seen before, she is 3 years old, and around 15.3…$4,500
Whitesboro, TX


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A dermal, transdermal, mucosal or transmucosal delivery device is provided. The device includes a backing layer, defining an ingredient containing reservoir, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the dermis or mucosa.
1. An ingredient delivery device, comprising:
a backing member defining an ingredient containing reservoir, said backing member being made of a material which is substantially impermeable to ingredients contained in said reservoir;
an ingredient contained in said reservoir comprising an organic solution, wherein said organic solution comprises:
a topically active drug agent;
an alkylene glycol;
a fatty acid ester;
a dialkylene glycol alkyl ether; and
a polymeric thickening agent;
a cover for said reservoir, said cover being made of a material substantially impermeable to ingredients contained in said reservoir, but having at least one opening therein, such that ingredients to be delivered from said reservoir will flow through said opening, but will not readily flow through said material of which said cover is made;
said cover being sealed to said backing member at the perimeter of said reservoir by a first seal which is not subject to degradation by any ingredient to be contained in said reservoir;
an adhesive layer adhered to said backing member for adhering said device to a patient's skin or mucosa, said adhesive layer not extending to the perimeter of said opening in said cover, such that a portion of said cover surrounding said perimeter of said opening is exposed to thereby define a cover sealing surface; and
a liner covering said sealing surface of said cover and said opening in said cover, said liner being releasably sealed to said sealing surface of said cover by a second seal which is not subject to degradation by any ingredient contained in said reservoir; whereby ingredients contained in said reservoir are sealed therein during storage and non-use by said first and second seals, said cover and liner, but are free to flow through said opening and onto a subject's skin or mucosa when said liner is removed from said device and said device is applied to such skin or mucosa.
2. The device of
3. The device of
4. The device of
an outer protective layer and a barrier layer with an adhesive coating therebetween, and a release coating on the exposed surface of said barrier layer;
said barrier layer, including its adhesive coating and its release coating, having an opening therein which is sufficiently large to expose said opening and said sealing surface of said cover, whereby said outer protective layer is sealed directly to said sealing surface of said cover by said second seal.
5. The device of
a first adhesive coating, a second adhesive coating and a barrier layer therebetween;
said barrier layer, including its first adhesive coating and its second adhesive coating, having an opening therein which is sufficiently large to expose said opening and said sealing surface of said cover, whereby said outer protective layer is sealed directly to said sealing surface of said cover by said second seal.
6. The device of
7. The device of
8. The device of
9. The device of
10. The device of
11. The device of
12. The device of
[0001] This application claims the benefit U.S. Provisional Patent Application No. 60/433,203, filed Dec. 13, 2002, the disclosure of which is hereby incorporated by reference in its entirety.
[0002] The present invention relates generally to dermal, transdermal, mucosal or transmucosal ingredient delivery devices. Such devices are designed to deliver ingredients to the skin or exposed mucosa of a subject. The device is referred to "dermal" or "transdermal," as a function of whether or not the ingredients are formulated in such a way as to remain on the user's skin and be active there, or pass through the skin. The same distinction applies with respect to "mucosal" or "transmucosal" devices, but with reference to an exposed mucosal layer.
[0003] The ingredients to be delivered may vary widely. They may be "drug" ingredients, oral care ingredients such as flavors, drugs, etc., or they could be cosmetic ingredients such as perfumes, creams or the like. The term "active" ingredient as used herein is intended to refer to the primary ingredient or ingredients to be delivered by the device, and is not intended to be used in its "FDA" sense as referring only to "drugs."
[0004] Devices for transdermal or percutaneous drug delivery and devices are typically characterized by delivering an amount of a drug or other ingredients, e.g., nitroglycerin, estrogen, estradiol, corticoid, levonorgestrel, etc. to the patient's skin at a rate controlled by the device. In a transdermal or transmucosal device, the drug is delivered systemically to the intended site of treatment within the body. Although effective for their intended use, such controlled release devices have limited utility for providing the kind of treatment which requires maximum delivery of the drug or active ingredient for local skin conditions, for example, lesions or abnormal skin features such as corns, warts, calluses, bunions, actinic keratoses and hard hyperkeratotic skin as is often found on the face, arms, legs or feet.
[0005] U.S. Pat. No. 4,849,224 to Chang et al. discloses an ingredient delivery device comprising a backing layer which defines an ingredient containing reservoir covering a microporous membrane that is permeable to the ingredients contained in the reservoir. The microporous membrane is heat sealed to the backing layer in the area surrounding the perimeter of the reservoir. An adhesive layer is adhered to the backing layer in the area surrounding the mircoporous membrane. A release liner covering both the adhesive layer and the microporous membrane is heat sealed to the backing layer concentric to and outwardly from the heat seal between the microporous membrane and the backing layer. In a second embodiment, Chang '224 discloses a similar arrangement, but with a peel sealable inner liner which underlies the microporous membrane and portions of the backing film. It is the inner liner, rather than the release liner, which is then heat sealed to the backing layer with a peelable heat seal which is concentric with the heat seal between the microporous membrane and the backing layer. In this device, both the release liner and the inner liner must be removed prior to application of the device to a patient.
[0006] Chang et al. U.S. Pat. No. 4,983,395 discloses a device which is similar to the second embodiment of the Chang '224 patent, except that 1) the membrane layer underlies some or all of the backing layer, 2) the inner liner, membrane and backing layer are all sealed together at the perimeter of the reservoir, and 3) the inner liner is adhered by an adhesive layer to the release liner.
[0007] Other types of delivery devices such as medicated plasters have been used for corns, warts, calluses, etc. However, the amount of active ingredient that can be delivered by such plasters is limited by the dimensions of the plaster and solubility of the active ingredient in the plaster. Consequently, repetitive applications are required for effective treatment. It would be desirable to provide a device which would provide maximum delivery of dermatological ingredients for local skin conditions or therapeutic drugs for delivery to the bloodstream.
[0008] The ingredient delivery device of the present invention comprises a backing layer, sometimes referred to herein as a base member, defining an ingredient containing reservoir, and a cover for the reservoir which is made of a material substantially impermeable to ingredients to be contained in the reservoir, but having at least one opening therein such that ingredients will flow readily through the opening but will not readily flow through the material of which the cover is made. The cover is sealed to the backing member at the perimeter of the reservoir by a first seal which is not subject to degradation by any ingredient to be contained in the reservoir. An adhesive layer is adhered to the backing layer for adhering the device to a patient's skin or mucosa. The adhesive layer does not extend to the perimeter of the opening in the cover, such that a portion of the cover surrounding the perimeter is exposed and thereby provides a cover sealing surface. A liner, preferably a release liner for the device, covers the sealing surface of the cover and is releasably sealed to the sealing surface by a second seal which is also not subject to degradation by any ingredient to be contained in the reservoir. The ingredients contained in the reservoir are thereby sealed therein during storage and non-use by the first and second seals, the cover and the liner, but are free to flow through the opening in the cover and onto a patient's skin or mucosa when the liner is removed from the device and the device is applied to the skin or mucosa.
[0009] These and other features, objects and advantages of the invention will be more fully understood and appreciated by reference to the written description and appended drawings.
[0010]FIG. 1 is an exploded cross-sectional view of the principle subassemblies of the device of the preferred embodiment;
[0011]FIG. 2 is an exploded cross-sectional view, showing portions of the major subcomponents of the device of the preferred embodiment;
[0012]FIG. 3 is a plan view of the device of FIGS. 1 and 2, showing the device which is applied to a patient's skin or mucosa;
[0013]FIG. 4 is a similar plan view of an alternative embodiment device having a somewhat different configuration from the device of FIGS. 1-3; and
[0014]FIG. 5 is a chart displaying a comparison of flux in salicylic acid formulas contained in devices of the preferred embodiment to medicated plasters in the prior art.
[0015] It will be appreciated that the thicknesses and shapes for the various layers have been exaggerated in the drawings to facilitate understanding of the device. The drawings are not "to scale."
[0016] In the preferred embodiment, device 1 comprises a backing layer (sometimes referred to as a base member) 10 defining a reservoir 16 for containing an ingredient or ingredients 18 (FIGS. 1 and 2). A cover 14 having an opening 15 therein is sealed to backing member 10 around the periphery of reservoir 16 by a seal which is not subject to degradation by ingredients to be contained in reservoir 16. Adhesive layer 11 is adhered to backing member 10 and serves to adhere the device to a patient's skin or mucosa. Adhesive layer 11 may cover a portion of cover 14, but does not cover opening 15, and preferably leaves a portion of the surface of cover 14 exposed in the area surrounding opening 15, the area being referred to herein as cover sealing surface 14A. Liner 12 covers at least opening 15 and sealing surface 14A of cover 14, and is sealed to sealing surface by a second seal which is not subject to degradation by any ingredient to be contained in the reservoir. Preferably, liner 12 comprises the release liner for the device, and therefore covers not only opening 15 and sealing surface 14, but also releasably covers adhesive layer 11. When device 1 is to be used, release liner 12 is removed, thereby exposing opening 15. Device 1 is then applied to the patient's skin or mucosa via adhesive layer 11, with reservoir 16 and cover opening 15 positioned over the area to which ingredients 18 are to be delivered.
[0017] Backing layer or base member 10 is made of a material which is substantially impermeable to ingredients 18, for example, 3.0 mil, 3M� 9722 polyethylene film. Ring-shaped cover 14 is also made of a material which is substantially impermeable to ingredients 18 contained in reservoir 16, for example, 4.0 mil ROLLPRINT� polyethylene film that forms a reservoir 16.
[0018] The size or diameter of opening 15 may vary, as a function of the speed with which one wants to deliver active ingredients, or the total amount of active ingredient one wants to deliver from reservoir 16. Depending on intended use, the diameter of opening 15 may range from 0.05 to 5.0 inch. The larger openings would require the use of hydrogel in the reservoir, so the ingredient solution does not immediately run out of reservoir 16 when liner 12 is removed. In the preferred embodiment as shown, the diameter of the opening is approximately 0.125 inches.
[0019] Ingredients 18 may be contained within reservoir 16 in any of a variety of ways. For example, ingredients 18 can simply be in liquid form within reservoir 16. The ingredients may be contained in a pad of hydrogel material, which basically comprises a gel matrix containing ingredients to be delivered through opening 15. Alternatively, ingredients 18 may be contained in a woven or non-woven absorbable material pad located in reservoir 16, made of, for example, 5.0 mil STRATEX� 90% polypropylene/10% non-woven rayon. Other suitable materials for the absorbable woven or non-woven material include any non-dimensionally stable materials, such as woven polyester cloth, bonded nylon fibers, cotton gauze, fiberglass, polyester fibers and cotton fibers. This material may partially or completely contain the ingredient or ingredients to be delivered to the user's skin or mucosa.
[0020] The term ingredient or ingredients as used herein refers to all ingredients contained within reservoir 16, and not only to those of the ingredients which are to be delivered to or through the user's skin or mucosa. The latter may be referred to as "active" ingredients in the broadest sense. However, the term "active" ingredient is not intended to limit the ingredients to be delivered to drugs, since other types of ingredients may be delivered for purposes other than to serve as a drug.
[0021] Adhesive layer 11 is preferably a composite of three different layers (FIG. 2) as follows: first or upper adhesive layer 20, made of, for example, a 1.0 mil, NATIONAL STARCH 80-1197™ acrylic adhesive; barrier layer 22, made of, for example, a layer of 0.5 mil, PET film; and second or lower adhesive layer 24, made of, for example, 3.0 mil, NATIONAL STARCH 80-1197™ acrylic adhesive that comes into contact with the patient's skin. Other suitable materials for attaching the device 10 to the skin or mucosa can include waterproof tape or other materials that have an adhesive underside. Pressure sensitive adhesive is preferred. The adhesive may be resistant to permeation and/or dissolution by the ingredients in reservoir 16, but this is not essential in view of the first and second seals discussed above. Other suitable adhesives may include but are not limited to the following: A. Solvent-based acrylic adhesives such as: Monsanto GMS 737, trademark of Monsanto Corporation, St. Louis, Mo.; National Starch Durotak 72-9720 and 80-1197, trademark of National Starch & Chemical Corp., Bridgewater, N.J.; Ashland's AROSET 11 13-AD-40 and 1085-A-45, trademark of Ashland Oil Co., Ashland, Ky.; B. Solvent-based rubber adhesives such as: National Starch 36-6172; C. Acrylic emulsion adhesives such as: Monsanto GME 2397 Rohm & Haas N580, trademark of Rohm & Haas Co., Philadelphia, Pa.; Unocal 76 RES 9646, trademark of Unocal Corp., Los Angeles, Calif.; and Ashland's AROSET 2022-W-50. C. Adhesive Transfer Tapes such as: 3M F-9465 PC, trademark of 2M Co., St. Paul, Minn. Avery-Denison MED 1116, trademark of Avery Dennison Corp., Pasedena, Calif.; ARCare 7530, trademark of Adhesive Research Inc., Glen Rock, Pa.; and RX230U, trademark of Coating Science Inc., Bloomfield, Conn.
[0022] The upper and lower adhesive layers 20 and 24 are both adhered to the intermediate barrier layer 22. Adhesive layer 20, in turn, is adhered to backing member 10, and also partially to cover 14, but does not extend beyond and over the sealing surface 14A of cover 14.
[0023] Release liner 12 also preferably is comprised of a plurality of layers of material as follows: release coating layer 26 made of, for example, LOPAREX� (REXAM�) 92A release coating; barrier layer 28 made of, for example, 3.0 mil, PET film; adhesive layer 30, made of, for example, 1.0 mil NATIONAL STARCH 80-1197™ acrylic adhesive; and outer protective layer 32, which is a co-laminated film of polyamide and polyolefins layer, made of, for example, TOLAS™ 4050.
[0024] Release coating layer 26 is bonded to barrier layer 28. Adhesive layer 30 is bonded to the other side of barrier layer 28, and to outer protective layer 32. This entire assembly of layers functions as a unitary release liner.
[0025] As best seen in FIG. 2, release coating layer 26, barrier layer 28 and adhesive layer 30 preferably have openings which are coextensive with the opening left in adhesive layer 11. In other words, layers 26, 28 and 30 of release liner 12 only partially overlie cover 14, and leave sealing surface 14A and opening 15 exposed. Outer protective layer 32, on the other hand, has no such opening and entirely covers sealing surface 14A and opening 15 of cover 14. Thus it is preferably the exposed inner surface portion 32A of outer protective layer 32 which is sealed to sealing surface 14A of cover 14 by the previously referred to second seal which is not subject to degradation by any ingredient to be contained in reservoir 16.
[0026] While those skilled in the art could probably select adhesives for the first and second seals which would not be degradable by the particular ingredients to be contained in reservoir 16, the first and second seals are preferably heat seals. Thus, cover 14 is preferably heat sealed to backing layer 10 in the area thereof surrounding reservoir 16, and outer layer 32 of release liner 12 is preferably heat sealed in area 32A to sealing surface 14A. The materials and sealing conditions used to seal area 32A to sealing surface 14A are preferably such that this second seal is "releasable" when force is applied to remove release liner 12 from adhesive composite 11. In contrast, the first seal between cover 14 and backing layer 10 should be "permanent" to the extent that cover 14 is not peeled away from backing layer 10 when a force is applied to remove release liner 12 from the assembly.
[0027] The preferred embodiment device may also include a shell covering the exterior of reservoir 16. The shell of the device should be impermeable or impervious to the liquid being delivered to the treatment site, in order to prevent loss by evaporation or wetting. The shell may also protect the active ingredient and/or liquid against radiant energy sources such as ultraviolet and visible light. The shell can be either dimensionally stable or dimensionally non-stable, preferably dimensionally non-stable. A dimensionally non-stable shell is not capable of withstanding a compressive force of one psi or less, i.e. will at least partially crush or collapse. Suitable materials for the shell can include but are not limited to ceramics, metals such as titanium, aluminum or steel, plastics such as polyolefins, barex, styrene, polyesters, polyacrylics, vinyl polymers, polyamides, polyfluorocarbons, polyimides, polylactams, polyaramides, polycarbonates, polysulfones, polyethylene, polypropylene, nylon, polyvinyl chloride or composites thereof. It will be appreciated that the shell could replace the reservoir defining portion of the film of material comprising backing layer 10. In that case, the reader should consider the shell to be a part of backing layer 10 for purposes of this discussion. The shell would then be the portion of backing layer 10 defining reservoir 16 for containing the ingredients to be delivered. Reservoir 16 of the device is a structure having sufficient interior surface area to retain the ingredients against a gravitational force by means of surface energy to prevent the liquid from readily draining out of the reservoir. The reservoir can be either dimensionally stable or dimensionally non-stable, as discussed above. The heat seal around reservoir 16 should also be resistant to permeation, disintegration or degradation e.g., dissolving by the ingredients and actives contained herein.
[0028] Turning to FIG. 3 which is a plan view of the device of the present invention, there is an opening 15 in cover 14 for release of the medication to the patient's skin from the reservoir 16 that contains thin absorbable ingredient containing woven or non-woven layer 18, which, in turn, is contained within the cover 14 that is sealed to backing layer 10. A kiss cut line 12 a is present in release liner 12 to aid in removing the disposable release liner 12. FIG. 4 is an alternative shape of the object of the present invention.
[0029] Preferred embodiment device 1 delivers active ingredients at high concentrations over short periods of time (i.e. ranging from about 0.1 hour to about 24 hours per wear). Some active ingredients at lower concentrations may be delivered for more than about 24 hours. The preferred embodiment device 1 is useful for delivering active ingredients in liquid solution without adding or incorporating an adhesive film (i.e. with no layer between the skin and the liquid containing the active ingredient) into the preferred embodiment device 1. Preferred embodiment device 1 may be used to treat the following conditions or to deliver the following active ingredients, the conditions and active ingredients including, but not limited to: warts (i.e. salicylic acid, and/or other keratolytic agents); acne (i.e. salicylic acid, benzoyl peroxide, antibiotics, and/or other keratolytic agents); pain (i.e. local anesthetics, non-steroidal anti-inflammatory drugs); moisturizers (i.e. urea, water); finger and toenail beds (i.e. urea, water, anti-fungal agents); skin buffering (i.e. buffering agents); vaccines (i.e. small pox, measles, flu, anthrax, polio, etc.); poorly soluble drugs; larger molecular weight molecules (i.e. about 500 to about 1500 molecular weight molecules such as heparin, LHRH); wound care (i.e. water, debriding agent(s), enzymes); sampling and diagnostic agents (i.e. glucose, lactic acid, potassium, allergens, etc.); iontophoresis, electroporation, sonophoresis, radio frequency, thermal enhancement (reservoir) (i.e. electrode (anode, cathode)); microneedles (reservoir) (i.e. alone or in combination with iontophoresis, electroporation, sonophoresis, radio frequency, thermal enhancement). The preferred embodiment device 1 may also be combined with other components, deliver other active ingredients, and/or deliver molecule(s) for diagnostic purposes to the skin.
[0030] Preferred embodiment device 1 was tested using an organic keratolytic agent solution which is basically non-aqueous not withstanding trace amounts of water. Such keratolytic agents include salicylic acid or salts or esters thereof, glacial acetic acid, glycolic acid, phenoxyacetic acid, ascorbic acid, retinoic acid (tretinoin), fluorouracil, calcium pantothenate, cantharidin, podophyllum, phenol, zinc chloride, tannic acid, castor oil, or mixtures thereof. The amount of active ingredient in the liquid can range from about 1 to about 40% by weight, preferably from about 5 to about 30%, most preferably 20% by weight. Most preferably, the active ingredient is salicylic acid or a salt or ester thereof. Suitable salts include the sodium, potassium, calcium or magnesium salts thereof. Suitable esters include C1 to C4 esters thereof, such as methyl salicylate. Other esters include salsalate (salicylsalicylic acid), the salicylate ester of salicylic acid. Salicylic acid was used in the examples below.
[0031] Salicylic acid has a history of safe use for the treatment of a variety of skin conditions. The topical uses of salicylic acid under the OTC monographs considered to be safe and effective are: a topical acne treatment (21 CFR 333.310; at 0.5-2%); the removal of warts (21 CFR 358.110) when used in a plaster vehicle (12-40%), in a collodion-like vehicle (5-17%) or in a karaya gum, glycol vehicle (15%); the removal of calluses and corns (21 CFR 358.510) when used in a plaster vehicle (12-40%) or in a collodion-like vehicle (12-17.6%); and the control of dandruff, seborrheic dermatitis and psoriasis (21 CFR 358.710; at 1.8-3%).
[0032] Salicylic acid produces desquamation of the horny layer of skin while not affecting the structure of the viable epidermis by dissolving intercellular cement substance. The keratolytic action causes the cornified epithelium to swell, soften, macerate and then desquamate. (Drug Facts and Comparisons, 2000).
[0033] The organic solution described below has been shown to enhance the mobility of salicylic acid through the skin as can be seen from flux measurements on cadaver skin shown in FIG. 5 as set forth below. The organic solution provides an improved vehicle for salicylic acid and/or other medicaments, which promotes the removal of warts, corns, calluses, and other keratolytic skin lesions.
[0034] The medicated devices of this embodiment, containing this solution, overcome problems existing with currently available medicated pads because the rate and extent of transfer of salicylic acid from the device across the stratum corneum is much faster than the rate of and extent of salicylic acid transfer in other commercially available solutions as demonstrated below in FIG. 5. The medicated devices of this embodiment deliver topically at the site of the wart, corn, or callus, thereby avoiding any significant systemic absorption.
[0035] Furthermore, the organic solution has a low volatility at ambient temperatures. Previous formulas showing high flux (transfer rates) of salicylic acid across the skin were composed of lower molecular weight, more volatile solutions that are difficult to contain. Therefore the described salicylic acid solution has the advantage of being more stable and having a longer shelf-life than previous formulas. The organic solution is described in more detail below.
[0036] One component of the organic solution is a solvent composed of compounds such as C2-Cg alkylene diols, e.g., butylene diol, pentylene glycol, neopentyl diol, propylene glycol being preferred. Also included solvents are such as diethylene glycol, monoethyl ether or like compounds such as Di C2-C5 alkylene dio, mono C1-C4 alkyl ethers, e.g., dipropylene glycol, mono propyl ether, polypropylene glycol and co-polymers, mono poropy ether, polyethylene glycol, mono ethyl ether. Suitable surfactants for the organic solution include, for example, monoglycerides or like compounds such as glyceryl mono-oleate, -laurate, -behenate, -eicosadioate, -sterate, or other fatty acid mono substituted glycerides. Suitable film formers for the organic solution include, for example, polyacrylamide or other like compounds which act as thickening agents such as other acrylamide copolymers, polyacrylate copolymers, cellulosic polymers and copolymers, and poly vinyl pyrolidone polymers and copolymers.
[0037] The device can be applied to cover the wart, corn or callus for an appropriate time period, such as for example, 4 to 24 hours, or optionally it may be removed after 8-10 hours of treatment. Alternatively, the device can be applied to cover the wart, removed after 8-10 hours of treatment, after which the procedure can be repeated.
[0038] The following is the listing of ingredients of keratolytic treating solution discussed above.
[0039] The salicylic acid is present as an active ingredient. The Propylene Glycol USP, Monoglycerides NF and Diethylene Glycol Monoethyl Ether NF are present as solvents. The Sepigel 305 is present as a viscosity modifier. The salicylic acid is preferably in an amount of 125 mg/patch. Preferably, the ingredients are present in the following amount by weight of ingredient per formulation.
[0040] The following procedure is representative of the manufacturing process for the bulk Salicylic Acid Topical Solution 20% drug product. Into a suitable vessel equipped with a propeller mixer, add Propylene Glycol. Begin mixing. With continued mixing (400 rpm); add Sepiegel 305 and mix until an essentially clear viscous material is produced (2-4 hours). Add Diethylene Glycol Monoethyl Ether; mix until uniform (1 hour). Add Glycerol Monooleate and mix until dissolved (1 hour). The solution will be hazy. Add Salicylic Acid slowly over 2 hours and continue to mix for 4 hours. The product will be a viscous, clear solution (less viscous than after step 2).
[0041]FIGS. 1 and 2 show the layers of materials used to manufacture the preferred embodiment device 1. The layers of materials that may be used in the manufacture of the device are listed below. Generally, the preferred embodiment device 1 includes a backing layer 10, an adhesive layer 11 and a release liner 12.
[0042] The following is a description of from the backing layer to the release liner (top to bottom on FIGS. 1 and 2) by layer number and description:
[0043]10. Backing layer, i.e. 3.0 ml, 3M� 9722 polyethylene film;
[0044]18. Reservoir ingredients, i.e. 5.0 mil STRATEX� 90% polypropylene/10% non-woven rayon;
[0045]14. Cover, i.e. 4.0 mil ROLLPOINT� polyethylene film;
[0046]11. Adhesive layer
[0047]20. First adhesive coating, i.e. 1.0 mil National Starch 80-1197 acrylic adhesive
[0048]22. Barrier layer, i.e. 0.5 mil PET film; and
[0049]24. Second adhesive coating, i.e. 3.0 mil National Starch 80-1197 acrylic adhesive;
[0050]12. Release liner;
[0051]26. Release coating layer, i.e. LOPAREX� (REXAM�) 92A release coating;
[0052]28. Barrier layer, i.e. 3.0 mil PET film;
[0053]30. Adhesive coating, i.e. 1.0 mil NATIONAL STARCH 80-1197™; and
[0054]32. Outer protective layer, i.e. TOLAS™ 4050;
[0055] Any commercially known method of manufacturing the preferred embodiment device 1 may be employed. However, one preferred method of producing device 1 includes the following steps: 1) pre-cut the materials used in the backing 10 and the reservoir layer 16 (i.e, pre-cut cover 14 and any woven and/or non-woven ingredients); 2) peel away the strip layers from first adhesive layer 10 and second adhesive layer 24 and adhere the skin contact adhesive layer 11 to the release liner 12; 3) place cover 14 in position on completed step 2 assembly, heat seal cover 14 to the outer protective layer 32 and set aside; 4) form reservoir 16 in the backing material; 5) place ingredients 18 in the formed reservoir, insert any active ingredient(s), place completed step 3 assembly in position over reservoir 16 and heat seal backing 10 to cover 14; 6) die cut finished shape; 7) inspect for defects and contamination; and 8) place the finished device 1 in a pouch and seal the pouch.
[0056] The following examples were carried out in accordance with the above procedures. The following formulations were placed in the reservoirs 16 of devices made in accordance with embodiment 1.
[0057] The flux in salicylic acid for Formulas 1 and 2 dispensed in a device made in accordance with preferred embodiment device 1 were compared as shown in FIG. 5 to the flux achieved using Clear Away� wart remover of the prior art. Flux was compared to 10 hours at micrograms absorbed by cm2. As can be seen, the Clear Away� wart remover of the prior art had less than 50 micrograms absorbed/cm2. The devices of preferred embodiment 1 using formulas greater than nearly 700 and 800 cm2, respectively.
[0058] Having described specific preferred embodiments of the invention with reference to the accompanying drawings, it will be appreciated that the present invention is not limited to those precise embodiments and that various changes and modifications can be effected herein by one of ordinary skill in the art without departing from the scope or spirit of the invention as defined by the appended claims.
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Special friendship blossoms after loss of loved one
Friendship is something no one can predict. Some friendships are formed on the jungle gym in elementary school trying to see who can get to the top fastest, some are made in the classroom on the first day of college when no one knows what to expect, and some are made at the funeral home in your hardest hour.
Wait, what?
That's right, no one else expected it either. But for Katie Stroud, Scott Peoples, 35, of Memorial Funeral Home, was a blessing in disguise when she lost her mother in December of 2010.
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The saga of Candy Crush
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BBC: Candy Crush Saga - the "match-three" mobile game - was the highest grossing app on both iPhone and iPad in 2013.
Oregon needs a Grand Bargain energy planLinda Baker
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Undersea PowerJune 2015
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Mike Morrow and Mike Delos-Reyes first came up with the idea of an ocean power device 23 years ago, when they were students at Oregon State University. They realized a long-held vision last summer, when their startup, M3 Wave, successfully launched the first ocean power device that works underwater.
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Modern design defines new Portland indoor marketThe Latest
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An international architecture firm known for its design of the National September 11 Memorial Museum Pavilion in New York unveiled its plan this week for a modern indoor/outdoor food market at the foot of the Morrison Bridge in downtown Portland.
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Cherry RaincoatJune 2015
Tuesday, May 26, 2015
Spring rains are the bane of an Oregon cherry farmer's existence. Even a few sprinkles can crack the fruit so badly it's not worth picking. Science to the rescue: Researchers at Oregon State University have developed a spray-on film that cuts rain-related cracking in half, potentially saving a season's crop. The coating, patented as SureSeal, is made from natural chemicals similar to those found in the skins of cherries: cellulose, palm oil-based wax and calcium.
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|If you are going to wear stockings you will need a suspender belt to hold up your nylons. We have 6 or 8 strap belts and all have metal clips and adjustable straps to make your belt feel comfortable on you.
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Published: January 16, 2004
Europe Seeking Approval For Sanctions Against U.S.
The European Union asked the World Trade Organization for permission to impose sanctions on the United States for failing to change a law that the W.T.O. has already ruled an unfair subsidy for American corporations. That law allows American corporations to receive antidumping fines collected from foreign nations by the United States government.
The Europeans said they would begin retaliating with new duties on United States goods as soon as the W.T.O. approves their petition, a move sure to further heighten trans-Atlantic trade tensions. [Page C2.]
Bank of America Profits Increase
Strong mortgage lending and investment banking helped Bank of America increase profits by 4 percent in the fourth quarter. The bank's proposed merger partner, FleetBoston Financial, said its profit nearly tripled in the quarter. The chief financial officer of Bank of America said the bank had $274 million of exposure to Parmalat at the end of 2003. [C3.]
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Profits at Samsung Increase 24%
Samsung Electronics reported that profits rose 24 percent in the fourth quarter as demand for its liquid crystal display screens and flash-memory chips used in digital cameras charged ahead. [World Business, Section W.]
Daimler Adding to Mitsubishi Stake
DaimlerChrysler will buy an additional 22 percent of Mitsubishi Fuso Truck and Bus from Mitsubishi Motors for about 52 billion yen ($489 million). The move will give Mitsubishi Motors, one of the most indebted carmakers in the industry, cash to develop new models. Rolf Eckrodt, left, the president of Mitsubishi Motors, said the decision would help the carmaker focus on its passenger car operations. [World Business, Section W.]
Dow and S.&P. Gain; Nasdaq Dips
Investors facing strong earnings but tepid revenue outlooks left stocks little changed. The Dow Jones industrial average gained 15.48 points, to 10,553.85, and the Standard & Poor's 500-stock index finished up 1.53 points, at 1,132.05. The Nasdaq composite index, however, fell 2.05 points, to 2,109.08. [C4.]
Retail sales rose 0.5 percent in December, to $325 billion, the Commerce Department said. In another report, the Labor Department said consumer prices edged up 0.2 percent in December, capping a year in which costs, excluding food and energy, rose 1.1 percent, the smallest increase in 43 years. [C2.]
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The developer Bruce Ratner is negotiating to buy the New Jersey Nets and install the team in a glamorous new home designed by a world-renowned architect, at the corner of Flatbush and Atlantic Avenues in Brooklyn. [A1.]
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Education Nation: Questions for Milton Chen
Individual teachers and entire school districts are reinventing the learning model and pushing the boundaries of traditional teaching methods with great success. Milton Chen's new book Education Nation: Six Leading Edges of Innovation in Our Schools, chronicles these examples and pushes for major reform in education. Chen is a senior fellow and executive director emeritus … Continue reading Education Nation: Questions for Milton Chen →


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Abuse Support Group
10267 Members Strong and Growing!
6 hours ago in Abuse
right now just thinking that if every one try to make other happy than i hope no one will be sad but everyone is busy do always good things only for their selves not for others even as a human being we are all same and everyone have feelings and emot...
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12 hours ago in Abuse
Can anyone HELP.......For the longest time I've been Masturbating I mean countless times a day from the time I wake up till the time I go to bed sun up till sun down. I guess my question/concern is this healthy. It's to the point and all have been I ...
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I need help I have been addicted to masturbation for 6 month now. I want it to stop but I need help. I want to go on a 30 days challenge. Would appreciate any help I can get. Thanks in advance
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WALLA WALLA — A man who was shot and left for dead in an Eastgate alley in April identified his assailant to a jury Tuesday.
Blake D. Nelson testified it was the defendant, Timothy T. Parlor, who shot him as Parlor's first-degree assault trial began in Walla Walla County Superior Court.
But the defense maintains Nelson is lying because he's afraid of retaliation from the real shooter and a drug-dealing enterprise to which the shooter belongs.
Parlor's attorney, Richard Wernette, told the seven-man, five-woman panel that Shawn A. Crump actually pulled the trigger and has "skated" with a "sweetheart" deal from the prosecution, landing him in prison for about a year after pleading guilty to a reduced charge.
The conflicting theories of the case unfolded in opening statements and testimony following jury selection in Parlor's trial, which might last through the week.
Prosecuting Attorney Jim Nagle said in his opening statement that Parlor, Nelson and Crump were at a gathering at Lucas Hancock's residence on Figueroa Street the night of April 12.
About 3 a.m., Parlor asked Nelson for a ride home, but Crump wanted Nelson to take him somewhere first.
The three, with Nelson driving his car, arrived in an alley behind the 1700 block of Portland Avenue where Crump and Parlor got out, and Parlor "took a .22-caliber pistol and he shot Blake Nelson," Nagle said.
Crump, 21, and Parlor ran to a nearby residence where Parlor allegedly made self-incriminating statements.
Meanwhile Nelson — who suffered three wounds, including a life-threatening one to his chest — staggered into Aziz Chevron, 1916 Isaacs Ave. He was taken to Providence St. Mary Medical Center where he was hospitalized for several days. He has since recovered.
The defense has quite a different theory of the assault.
Wernette told the jury in his opening statement that Parlor, 19, moved with his family to Walla Walla only 13 days before, was "a complete stranger to this town" and had just happened to meet Hancock.
Wernette maintained that Parlor had no motive to hurt Nelson, but Crump — "the true shooter in this case" — did. Wernette called Crump a liar, substance abuser and violent man who was a member of a "criminal association" called "The Regulators."
They believed Blake Nelson was a police informant and somehow had already "snitched" on their illegal drug enterprise, according to Wernette.
"Blake Nelson is literally scared for his life of Shawn Crump and his cronies," Wernette said.
Later, when Nelson, 27, took the witness stand under direct questioning by Nagle, he acknowledged having a problem with illegal drugs, including using "a lot of opiates, pain killers, heroin" at various times, and methamphetamine the night in question.
Nelson testified he drove to the alley at Crump's direction, but said he was shot by Parlor.
"I ask myself that every day. I don't even know him," Nelson replied.
Under cross-examination by Wernette, Nelson reiterated having had no problems with Parlor, conceded he had bought drugs from Crump in the past, and acknowledged he was concerned that some people at Hancock's residence might have thought he was a police snitch.
"Yeah, just how they were acting. They weren't really talking to me, like they had something set up like they were going to do something," he said.
Nelson also confirmed it was Crump — not Parlor — who gave directions to the alley and told Nelson where to stop.
Wernette asked Nelson if it occurred to him that Crump set him up. "He may have set me up, but he didn't pull the trigger," Nelson said.
He also admitted not being forthcoming to police early on in the investigation about who shot him because it crossed his mind he "wanted revenge."
In addition, Nelson conceded he probably was shot because one or more of "The Regulators" thought he was a police snitch.
"But it's funny. I'm not a snitch. I got shot for no damn reason."
Crump, who is expected to testify at Parlor's trial, pleaded guilty in July to lying to authorities by at first telling them he wasn't at the scene of the shooting. He's serving a 13-month prison term.
If Parlor is convicted as charged, including a firearm enhancement, he faces about 13-15 years behind bars.
Terry McConn can be reached at email@example.com or 526-8319.
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|2011 Pétrus
Dark red and black fruits, like many other 2014s, this wine shows more finesse than usual. There is great class and compacted substance. All coiled up right now, but should unfold nicely.
Already showing a multidimensional personality. Powerful, yet restrained. Silky. Long Long finish. I left Ausone with a smile on my face. The best of the 'Classe A' group, and probably the best of St. Emilion of the vintage.
A beautiful wine, very floral with great purity. Red fruits and rose petals, delicate, This will be quite pleasurable to drink, showing great elegance. It did feel a little thin, and lacking complexity at this stage. I assume this should gain weight in the bottle, but left me a tad underwhelmed. Has the substance and every right to improve once bottled. 94+
Very fragrant, great purity and alluring cashmere like texture. I found the Right Bank to bed bait of a mixed bad for 2014. The best have great balance, but show substantial finesse and elegance. Should be interesting to revisit once bottled. VCC for 2014 is very harmonious, and classy. Long, long finish. Not a blockbuster, but regal and stunning. This may very well be the top wine for the Right Bank, and one of better clarets for the entire region of Bordeaux. This is First Growth quality. 96+


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Ingredients: Water, brandy, infusion (1:6000) of ruta graveolens flowers organic and biodynamic®.
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Faulkner's Failures
Before becoming an acclaimed novelist, William Faulkner was a failed poet. NPR looks at what drove Faulkner from poetry to prose....more
Before becoming an acclaimed novelist, William Faulkner was a failed poet. NPR looks at what drove Faulkner from poetry to prose....more
At The Daily Beast, Nathaniel Rich riffs on William Faulkner's New Orleans:
William Faulkner had recently begun a draft of "Dark House," the novel that would ultimately become Absalom, Absalom!, when he arrived in New Orleans on February 15, 1934.
There are two Faulkners, and each of these Faulkners is embodied by one of the author's two favorite drinks, as Robert Moor posits in a recent Paris Review article.
The julep is High Faulknerian. Taking in the dense, lush language in his most lauded works—As I Lay Dying, The Sound and the Fury, and Absalom, Absalom!…But the other Faulkner, the one who stayed down south, exemplified by the Snopes trilogy and Sanctuary and Light in August, is more like a cold toddy: light, citrusy, superficially graceful, yet deceptively complex.
For Bookish, music writer and self-described "karaoke ho" Rob Sheffield lists which songs famous authors of the past would have belted out on karaoke night.
He's unquestionably right about Oscar Wilde crooning something from The Smiths, though it seems a missed opportunity not to have given James Joyce "Baby Got Back."
Which tunes do you think your favorite writers would have favored?...more
Take a look at William Faulkner's resignation from his postmaster job, which appears at Letters of Note:
As long as I live under the capitalistic system, I expect to have my life influenced by the demands of moneyed people. But I will be damned if I propose to be at the beck and call of every itinerant scoundrel who has two cents to invest in a postage stamp.
Maria Popova of Brain Pickings got her hands on a copy of William Faulkner's only children's book, written for his stepdaughter (and a few other children in his life) and published in a print run of 500.
With words like "choss" and "youall," it may not be the best way to teach kids new vocabulary, but if the beautiful description of waking up doesn't instill a lifelong desire to read, nothing will....more
Marco Kaye's "As I Lay Buying" takes Faulkner's classic backwoods family, The Bundrens, and throws them into a modern Macy's for some Holiday shopping.
What more can we say–it's funny. And even if you didn't like As I Lay Dying, we think you'll like Kaye's clever rendition....more
When William Faulkner originally published The Sound and the Fury, he wished Benjy's narrative could be printed in different colors to denote different time periods, lamenting that "I'll just have to save the idea until publishing grows up."
Now it has: The Folio Society is publishing an edition of the novel colored as Faulkner envisioned it....more
William Faulkner secured the first Writers-in-Residence position at UVA and held the position for two terms. This site has sonically preserved Faulkner's residency in the form of these recordings.
He held readings, gave a couple addresses and answered questions from UVA audiences, of which this site preserved 1690 minutes....more
There are bodies, and there are words. The bodies shift sides and see their components replaced; they look in mirrors and see themselves made horrific, the mechanical overtaking the organic, and they ask themselves whether they can still feel, still love....more


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Ripple of Hope Gala
Taylor was one of the honorees at the 2012 Ripple of Hope Gala. She was 2012 Ripple of Hope Award for her humanitarian works.
Taylor performed Starlight from her new album, Red, which was inspired by Ethel Kennedy.
Read more here.
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Post Categories: Charity, Gallery Updates, News


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Taking tips, chasing leads, and solving problems
Netflix error phishing scam warns of 'unusual activity' on account
Netflix users beware: If you try to log into your account and get an error notice stating that your username has been suspended because "unusual activity" has been detected on your account, it may be a phishing scam.
Criminals behind the Netflix scam will try to trick you into calling a fake Netflix customer service center or "tech support" team. If you call, a rep will not only try to convince you to pay to fix a non-existent problem with your computer. The scammers will also ask you to download software that gives them access to your computer and secretly download your personal files while you're on the phone with them.
MalwareBytes Unpacked first exposed the Netflix phishing scam a few days ago. Today, the Better Business Bureau Serving Wisconsin posted a warning about it.
The Netflix scam starts when the user tries to log into their accounts. A pop-up screen with the Netflix logo and the company's characteristic red logo color states:
"Important Notice: We have detected unusual activity on this account. To Protect your account from unauthorized use, we have temporarily suspended this username. To regain access to your account, please contact Member Services at 1-800-947-6570."
The message contains an error code, such as ERR19902881811.
MalwareBytes Unpacked got one of those scam messages and -- being tech experts -- played along to find out what happens and who the scammers are. (Don't do this!)
As the writer for MalwareBytes Unpacked explains, the phone number is not for Netflix. The call actually goes to a company in India, where an alleged customer service rep will ask you to download "Netflix support software." The software is really a remote login program called TeamViewer, which allows the scammer to access your computer.
"After remotely connecting to my PC, the scammer told me that my Netflix account had been suspended because of illegal activity," the MalwareBytes Unpacked writer explains. "This was supposedly due to hackers who had infiltrated my computer."
The rep showed the writer a fake "scan result" showing alleged hackings from Russia and China. The rep said a Microsoft-certified technician would need to fix the writer's computer. He gave the writer an invoice for anti-virus and software totaling nearly $400 -- as well as a fake $50 Netflix coupon.
The scary part is, while the supposed customer service person was on the phone with the MalwareBytes writer, scammers went through his personal files and uploaded interesting-looking files, including one that appeared from the title to contain banking information as well as a calendar.
The scammers also asked the writer for a photo ID and a picture of his credit card as proof of his identity. When he didn't have a photo, they tried to activate his web cam so he could show them. That's where the call ended.
"This was a clever plan which not only is about stealing money for bogus services but also about identity theft by gathering personal details from the victim (photo, name, email, address, password, etc.)," the MalwareBytes writer says. He posted a video of the call, which you can watch below.
As the BBB points out, if the victim refuses to send photos, the call will end, but the scammers may still get away with sensitive documents on the person's computer or their Netflix credentials.
"Although seeing it all in writing may raise numerous red flags, people are more likely to fall for this scam when it actually happens to them. This is because few people fully understand the inner workings of a computer or how to recognize fraudulent activity even if it is right in front of their eyes," the BBB writes in a blog post warning. "Many people are willing to trust anyone who claims to be a computer support specialist or professional, without asking any questions."
The BBB advises consumers who may have fallen victims to the scam to immediately change their username and password. Change the password if you use it for other websites as well.
If you have problems with your Netflix account, call the real customer support number, (866) 579-7172 or visit Netflix's help center online.
Microsoft and Windows "tech support" scams have been going around since at least last summer. They are still targeting Wisconsin consumers. You can read how those scams work and what to watch for in this Public Investigator story.
For more tips, scam alerts, consumer stories and an occasional freebie, follow Gitte Laasby on Twitter @GitteLaasbyMJS or like her Facebook page.
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I'm 14, and my boyfriend wants me to give him dry sex, I am very uneasy about this because I've been sexually abused before, what should I tell him?
I am 22 years old and have been with my one and only boyfriend for over 2 1/2 years now. I love him very much and we get along well, but our sexual life has always had problems. These are the main issues: 1) I cannot orgasm except through the use of a vibrator, 2) I'm often not interested in sex/don't really feel anything enjoyable from sex, and 3) I never initiate anything, which makes my boyfriend very frustrated. We've been having sex for about 2 years now, and these issues are as much of a problem as they were when we first started. Regarding the problem #1 (no orgasm except with vibrator), my boyfriend has tried everything. He will pleasure me for long periods of time, try to make me feel sexy, but NOTHING happens--I don't even come close to orgasming (in fact, I usually just get sore from the contact). I've tried to pleasure myself, but this is even worse--I hate the feeling of masturbating and don't derive any pleasure from it. When we discovered that I CAN orgasm via a vibrator, we were both thrilled; however, it usually takes me a good 15-25 minutes to orgasm from the vibrator (on the highest setting), and the orgasm usually lasts only a few seconds--it just feels like a lot of work for barely any result to me. Because I'm not interested in sex very often and I cannot orgasm via penetration or manual stimulation, my boyfriend believes I'm not sexually attracted to him and is quite upset. I don't know what to do and it is ruining our relationship. I am religious and come from a home schooled background where sex was not talked about much, and so I often feel awkward when my boyfriend tries to discuss it with me (and going to a sex therapist is out of the question).
Depending on your view, the answer to that question might seem really obvious or very tricky and hazy.
This is a subject that's talked about all the time, however, when it is, there's often little to no clear definition about what healthy sexual development is. Many easy assumptions get made, and ideas about what's healthy for all people are often based in or around personal agendas, ideas and personal experiences of sexuality, rather than being based in broader viewpoints, truly informed and comprehensive ideas about all that human sexuality and development involves and real awareness of possible personal or cultural bias.
We think this question is very, very tricky and that the answers aren't at all obvious or easy: sexuality is incredibly complex, especially given its incredible diversity, not just among a global population, but even within any one person's lifetime. Our cultures also are often sexually unhealthy in many ways, and so ideas about healthy sexual development, deeply iRead more...
Hello! I've been a big fan of Scarleteen for a while now. I'll be fully honest: I love Scarleteen!
So, it's truly an honor, thrill, and excitement to get to call Scarleteen a new home for my writing. Hey, they say home is where the heart is! While here, I'll be mostly writing about that magnificent phenomenon we call consent. And I can't wait to share with, hear from, and learn with you!
In my experience, getting to the heart of consent has usually involved paying close attention to detail. For example, I host consent workshops professionally, and at one point during past workshops, when the audience is generally settled and feeling comfortable opening up, I have asked, "Who here has ever had something silly and awkward happen during a hookup? Even slightly awkward." (When I say hooking up, I'm referring to sexual activity.) Hands have shot straight up and we all ended up getting a good laugh out of it. It just goes to show how awkward connecting with sex can be, whether you're in beRead more...
My best friend just came out to me and I came out to him... now he wants to have sexual relations, what do I do?
It all happened a week ago. He told me he was bi, I told him that I am gay. After an awkward conversation he told me that he wanted to have sex with me minus an actual relationship and he told me that he prefers women but likes men as well. This is all troubling to me because I don't have any interest in him as a partner and telling me that he likes women is a big turn off. But the guy has never had a relationship with a man or woman. I kind of feel bad for him, he has had a lonely life. I have had several relationships both platonic and sexual. I would like to find a way to tell him that I am not his guy without hurting his feelings. We have been friends for 6 years now and the only reason why I haven't told him that I was gay before this point is because of his families very conservative views.
On a side note, What is the best way to tell girls who are infatuated with you that you are gay without offending them? For whatever reason, people have a hard time actually believing that I am gay. Thank you for your help!
I'm a Christian, and I have decided to save myself till marriage. I'm perfectly fine with that. My boyfriend is fine with that too (we've been together a month), and respects my decision. However, like any celibate person would admit, sometimes I get these truly surreal urges for sex: I catch myself thinking that maybe even a little bit of touching while kissing would be fine, or I just think about what it would be like if we ever got married and ended up sleeping together. I have said nothing to my boyfriend, in case he misconstrues it as an invitation, but it has recently been very, very difficult to resist, especially with all these hormones making me want sex. I want to stay true to my decision to stay premaritally celibate, and I will pride myself on not being tempted, however my urges make the battle all the harder sometimes. Any suggestions?
I've been seeing this guy from school for a couple months: three to be exact. From the moment we've met he's been interested in having sex, especially after he found out that I am a virgin and now he wants to be my first. He's pressuring me for pictures and oral sex, which we did but now he's pressuring me more for full on sex. We're not dating or in a relationship, all he says is that we're connected, which I don't understand. A couple days ago he said that he would give me 8 weeks to decide if I am gonna have sex, which will be in March.
He's the first guy to give me any sort of sexual attention, any attention more like it, I've always felt unsure of myself because I'm not a size six. I want to have sex, but with him I feel as if giving into finally have sex will just end up becoming sex and then the door. I don't want my first time to be a one night stand affair, he's assured me that it wouldn't be that way, but he's a guy looking for some. I'm real confused about what I should do with him. I want more than just sex, but I feel as if I wait it out long enough a relationship will grow. Please give me some help.
I'm 15 and my bf told me about a week ago that he thought I should be loosing my virginity and a few days ago I did. I was ok with this and only said once that if it was ok with him I'd like to stop (the way he was looking at me was creeping me out), but it wasn't ok with him so he kept going. Afterwards I really creeped out and for some reason I started crying all over the place, which I can't explain. He doesn't get this either and got really upset about it. I wanna make things back up with him so I've said that we can try again and that I wont react so badly. Is there anyway I can calm down enough so that I don't upset him again by freakin out? Hope you can help xxx
Okay, well here is the thing: I'm a girl and I'm so afraid to be in a relationship for too long, because I think that I'm going to have to have sex. I know that my boyfriend right now wants it, but I really don't. He says he'll wait for me, but I'm still scared. I don't think that I will ever be ready to do it, and so I'm worried. What if I am NEVER ready?!
Information on this site is provided for educational purposes. It is not meant to and cannot substitute for advice or care provided by an in-person medical professional. The information contained herein is not meant to be used to diagnose or treat a health problem or disease, or for prescribing any medication. You should always consult your own healthcare provider if you have a health problem or medical condition.


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- Film, Media & Entertainment
- Hammersmith Road, Kensington, London, Gt Lon, W14 8UX
Visual Studio 2012 Launch Event - Reading
Tim Leung (VBUG)
Friday, October 5, 2012 from 6:00 PM to 9:00 PM (GMT)
Join us at the Microsoft's headquarters in Reading where we'll be celebrating the launch of Visual Studio 2012.
During the evening, you'll learn what Visual Studio 2012 has to offer, and also find out what's new.
Our guest speaker will be Shanku Niyogi from Microsoft. Shanku is actively involved in the development of Visual Studio and you can find more about his work below.
Pizza and refreshments will be provided free of charge during the evening.
If you work with Microsoft .NET and Visual Studio, you won't want to miss this event! Places are limited so make sure to sign up today!
Shanku Niyogi leads the team responsible for testing the next generation of Microsoft's developer tools, including the Visual Studio product line and the .NET Framework.
Most recently, as Director of Program Management, Shanku led the design team for Visual Studio Pro and Express, developer tools for platforms such as Windows, Office, and Azure, and managed and JavaScript programming languages.
Shanku joined the Visual Studio leadership team as GM in 2008, and delivered the first set of Visual Studio tools for Azure, and the Chakra Javascript runtime in Internet Explorer. Previously, Shanku had been a part of the .NET Developer Platform organization for nearly seven years, where he helped ship several version of ASP.NET, and helped incubate technologies such as ASP.NET AJAX, ASP.NET MVC, WCF RIA Services for Silverlight, and ASP.NET Mobile Controls. Shanku has been with Microsoft since 2008. Shanku holds a Bachelor of Mathematics degree in Computer Science from the University of Waterloo.
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Registration takes less than 1 minute.
Ocean carrier will offer two departures from Los Angeles and one from Oakland to Honolulu.
SeaLand and APL ships will call Packer Avenue Terminal at the Port of Philadelphia.
Several trade preference bills and Trade Adjustment Assistance also passed in addition to fast-track Trade Promotion Authority, and will now go to the House for another round of voting.
International Longshoremen's Association and employers represented by the United States Maritime Alliance will begin full wage scale meetings in mid‐September.
Total shipments and total revenues for third party logistics providers both fell in first quarter 2015 compared to fourth quarter 2014, according to a recent benchmarking report from the Transportation Intermediaries Association.
Daseke, Inc., an open-deck and specialty transportation company, announced it would merge with Charleston, S.C.-based Bulldog Hiway Express.


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Folks, we are so excited for what's to come in the next month or so. Celebrations abound! Here at Plowsharing, we'd like to celebrate 3 really important things coming soon... MOMS! FAIR TRADE! 30th ANNIVERSARY! Mother's Day is this Sunday, May 10! I don't know about you, but I love...
Our Fair Trade Mission
Plowsharing Crafts has provided meaningful income to skilled artisans around the world by marketing their products in the St. Louis area since 1985. We are a ministry of the St. Louis Mennonite Fellowship, one of two Mennonite churches located in the St. Louis area. Plowsharing Crafts is a member of the Fair Trade Federation, and a 501c3 not-for-profit organization. We are largely staffed by volunteers from the community, and we always welcome new friends to join our team.
Many of the products are made with sustainable and recycled materials.
Our food products are grown all over the world by small farmers using sustainable methods.


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Raw News
- FOX45's one on one conversation with Sheila Dixon ahead of mayoral campaign run
- US, Cuba reach agreement to open embassies
- 3 suspects indicted for alleged role in brutal murder of Arnesha Bowers
- Police: 3 officers identified after police involved shooting on Thursday
- Supreme Court extends same-sex marriage nationwide
- Maryland Governor Larry Hogan diagnosed with aggressive form of cancer
- Baltimore riots: raw footage
- Dylann Roof makes first court appearance; judge sets $1M bond
- Heidi Bernadzikowski's family responds to her killer's guilty sentence
- Obama expresses sadness, urges national reckoning on gun violence
- Most talked-about moments from Donald Trump's presidential announcement
- Donald Trump says he's running for president in 2016
- Former Spokane NAACP leader Rachel Dolezal: 'I identify as black'
- 11 indicted, charged with conspiracy and distribution of drugs
- Baltimore Mayor: we continue to assess the cost of the unrest
- Commissioner Batts Addresses Rise in Crime, Violence Against Juveniles, and Short-Staffed Police Force
- Child in critical condition after hit-and-run in Cherry Hill
- Sinclair Broadcast Group rings NASDAQ closing bell
- Rick Perry announces 2016 bid, a re-do from 2012
- Your Voice: Mayor Rawlings-Blake answers viewer questions
- Baltimore police union requests release of tapes, texts between command staff, city hall during riots
- One-on-one interview with Baltimore Police Commissioner Anthony Batts
- Lindsey Graham launches 2016 bid
- Martin O'Malley announces presidential bid for 2016 election
- Baltimore Mayor asked about recent spike in shootings
- Grand jury indicts 6 officers in death of Freddie Gray
- Baltimore: Moving Forward
- FOX45's Kathleen Cairns asks Baltimore Mayor about response time during riots
- AG Lynch opens civil rights investigation into Baltimore Police Dept.
- Ed Reed returns to Baltimore to announce retirement
- Hogan rescinds State of Emergency, all National Guard removed from Baltimore
- Baltimore Mayor asks DOJ to investigate whether police have 'pattern' of violating 4th amendment
- In Arkansas, Huckabee launches second White House bid
- Governor Hogan attends call for "Day of Prayer and Peace"
- Mayor Stephanie Rawlings-Blake attends the reopening of Mondawmin Mall
- MEMA director discusses upcoming weekend plans
- All six charged Baltimore officers in custody
- 6 Baltimore officers charged in Freddie Gray murder case
- City leaders applaud citizens' peaceful protests, discuss weekend's marches in press conference Thursday evening
- Baltimore Police Turn Freddie Gray Investigation Over to State's Attorney
- City School CEO: Police Want to do the Right Thing, Our Children Don't Perceive It
- NAACP: Future of Baltimore Will Be Forged by Citizens Who Care About Their Communities
- City-Wide Curfew of 10PM-5AM Starts Tuesday in Baltimore
- Governor Hogan: Baltimore City Families Deserve Peace & Safety
- Mayor Stephanie Rawlings-Blake and Family of Freddie Gray Speak
- The Latest: Large Crowds Expected for Freddie Gray Protest
- Baltimore Mayor Wants Answers in Freddie Gray's Death [4/24]
- Baltimore Police Commissioner Batts Discusses Reaction, Reform Surrounding Freddie Gray's Death
- Baltimore Police Presser on Arrest Leading to Freddie Gray's Death [4/20]
- Baltimore Hospital Says Man Injured in Police Encounter Dies [4/19]
PC Batts: Suspect Gregg Thomas has Turned Himself In
Updated: Tuesday, March 18 2014, 07:46 PM EDT
Police Commissioner Batts announced that Gregg Thomas, the primary suspect in shooting a police officer, has turned himself in.
Batts announced at a second conference held Sunday evening that Thomas turned himself in after an earlier presser Sunday afternoon.
The motive is "still an open question" at this time, according to Commissioner Batts.
Now that police have Thomas in custody, Batts vowed "our job is to bring him to justice."
Batts also reissued the warning that anyone who may have helped or harbored Thomas will be held responsible.
"Anyone who had an opportunity to give him a piece of bread, a car ride, a place to lay his head, we're going after them," promised Batts.
The Commissioner also thanked his officers who "stood tall in the face of an attack on one of our own, a member of our family."
Batts also read a statement to officers from Sgt. McNeill's wife who said, "I appreciate everyone's prayers, support and the long hours you put in to catch the man who shot Keith."
The Baltimore City Police Department was joined in the two-day search by the U.S. Marshals Service, the FBI SWAT Team, the city's Hostage Negotiation Team, the Anne Arundel SWAT Team, the Baltimore County SWAT Team and police officers, and Maryland State Police officers.
To see the original story, click here


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Professional Ratings: 90 Connoisseurs' Guide
Region: Napa Valley, California
Varietal: Cabernet Sauvignon
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