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Eylea Outperforms Other Drugs for Diabetic Macular Edema »
"In an NIH-supported clinical trial comparing three drugs for diabetic macular edema (DME), Eylea (aflibercept) provided greater visual improvement, on average, than did Avastin (bevacizumab) or Lucentis (ranibizumab) when vision was 20/50 or w"...
Read the Eylea Outperforms Other Drugs for Diabetic Macular Edema article »
In a clinical study in patients with Type 2 diabetes, Starlix® (nateglinide) was administered in increasing doses up to 720 mg a day for 7 days and there were no clinically significant adverse events reported. There have been no instances of overdose with Starlix in clinical trials. However, an overdose may result in an exaggerated glucose-lowering effect with the development of hypoglycemic symptoms. Hypoglycemic symptoms without loss of consciousness or neurological findings should be treated with oral glucose and adjustments in dosage and/or meal patterns. Severe hypoglycemic reactions with coma, seizure, or other neurological symptoms should be treated with intravenous glucose. As nateglinide is highly protein bound, dialysis is not an efficient means of removing it from the blood.
Starlix® (nateglinide) is contraindicated in patients with:
- Known hypersensitivity to the drug or its inactive ingredients.
- Type 1 diabetes.
- Diabetic ketoacidosis. This condition should be treated with insulin.
Last reviewed on RxList: 9/7/2011
This monograph has been modified to include the generic and brand name in many instances.
Starlix FDA Prescribing Information
Additional Starlix Information
Starlix - User Reviews
Starlix User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Here is a collection of user reviews for the medication Starlix sorted by most helpful.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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I have a few hundreds of output files, of which some contain error messages. Lets say I want to automatically put all files containing the string "ERROR_1" in a "subfolder_1", and the rest in a second "subfolder_2". This should be possible by piping grep somehow. What would be a useful syntax?
Take the 2-minute tour ×
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This should work.
This script will move the files into the subfolders. Modify the wildcard

subset: commoncrawl


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It was comradely of the BBC to screen a drama, The Road to Coronation Street, to mark the 50th anniversary of television's longest-running soap opera (the pride of rival ITV). And while the story-line was at times confusing for those of us not altogether familiar with the cast, what cannot be denied is the role played by soaps, from Corrie to EastEnders, in holding up a mirror to our national life. Nor is there any sign that the genre is on the wane. Channel 4 is about to pioneer a real-life soap, starring real people, set in the real London suburb of Notting Hill.
Whether or not Britain can claim authorship of the original television soap opera, however, the distilled vicissitudes of daily life have followed the spread of television around the world – with possibly unheralded effects. In the early summer of 1992, I reported briefly from Kishinev (now Chisinau), capital of newly independent Moldova. The region of Transnistria was trying to break away – it still is, but no longer violently. Shelling resounded from the hills; armed fighters were a common sight in city streets.
To sit in the reception of the main hotel in the early evening, however, was to witness a peculiar sight. The space gradually filled with young men in fatigues; they sought out somewhere to sit, casually laid down their weapons, and fell progressively silent as the appointed hour approached. For an hour or so they sat riveted to the latest episode of a Mexican soap opera. The Rich Also Cry, a Dallas-style romp about life, love and catastrophe, was broadcast across the vast territory of what had been the Soviet Union. That night's episode over, the shelling resumed and the fighters returned to their task.
You could argue that, as the Soviet Union collapsed into its various parts, The Rich Also Cry was a big factor, perhaps the decisive factor, in preventing all-out civil war. As a distraction, it was second to none. It kept Russian-speaking audiences anaesthetised from Kaliningrad in the west, where the naval base was disintegrating, to Vladivostok, where I and other Sakhalin-bound passengers were grounded for days by fog. The airport lounge was crammed when it came on, and if by chance you missed an episode, anyone could fill you in.
Russians now have their own, home-grown, TV soaps. But the racy imported kind are now playing big in, among other places, Iran, where they are dubbed into Farsi and shown on a half-heartedly banned satellite channel partly owned by Rupert Murdoch. Elsewhere in the Muslim world, television soap operas and sitcoms can be credited with keeping the public temperature down in Ramadan, through the long daylight hours of fasting.
Which might bring us back home with a bump. If the Government wants to draw the sting of threatened street protests this winter, it might encourage the broadcasters to make their soap operas extra-compulsive viewing as the dark and the cold set in.
Fast forward to the Seventies (the 1970s, that is)
Nothing makes you feel older than the return of phenomena you remember from ... well, let's just say long ago. I've recently felt as though I'm watching a 1970s, even late 1960s, replay. Drinks companies want to reintroduce returnable bottles (good for the environment and for extra pocket money). There is a loud lament for the return of flat-sharing, now it's so difficult to get that first "foot on the property ladder" – though I can't for the life of me understand why this is so terrible. Everyone did it in my day, and a fine rite of passage it was. No one expected to be able to buy a house straight from college.
Two more signs of the times. Teachers are apparently at a loss – all over again – to know what to do about the "distractingly" brief skirts girls are wearing to school, and calling for a ban on the 12-inch long (i.e. short) uniform skirts sold at a certain supermarket. What used to happen was that head-mistresses (as we called them then) got the girls down on their knees and measured the distance from ground to hem with a ruler. That was the apocrypha, at least.
And now, praise be, that ugly-American import, "dress-down Friday" is going. Civil servants have been told to smarten up on all five days of the working week, and the rest of us will surely have to follow. Eliminating that ill-defined "smart casual" strand from our wardrobes will not only save money, but enhance the street and office scene, too. Why didn't anyone think of that before?
Miliband junior must escape from his T-free zone
A few weeks ago, I tipped Ed Miliband to beat David to the Labour leadership on the grounds that traditional leadership qualities, as exemplified in elder siblings (confidence, bossiness, etc) were now less in demand that the softer skills (sociability, compromise) more characteristic of their younger brothers and sisters. If Ed wins, though, he will have to perform at the despatch box against David Cameron, and he is going to have to find a few Ts from somewhere, if he wants to persuade anyone beyond the vanishing New Labour caste.
I've heard several interviews with the younger Miliband recently, and I listened in vain for a letter T, so completely has he assimilated the Blairite glottal stop. In the family, I suppose, he doesn't need one, what with brother David, his late father Ralph, his mother, Marion, and his son, Daniel, though a T might come in useful for his partner, Justine.
Talking of annoying speech habits, I'm preparing a quiver of tranquilliser darts to shoot at the next speaker who fills the non-existent space between the end of a sentence and the full-stop with the phrase "going forward". It's otiose and it doesn't mean anything.
Migrants have far more to offer than hard work and wealth creation, yet too many exist in isolation from the rest of society
Children are being segregated in British schools, report warns
Lieutenant Colonel Robin Davies: Marine who saved Britain's Resident in Borneo from hanging and averted an Iraqi invasion of Kuwait
Man dies instantly after shooting firework from top of his head
British astronomers discover five supermassive black holes
Greek debt crisis: Yanis Varoufakis resigns after being forced out by EU chiefs
Dorothy Bohm interview: 91-year-old photographer on portraying humanity and hope after escaping the Nazis as a teenager
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It may seem a little insane, but we promise it's worth it. We're bringing you the live music you shouldn't miss for every night of the week in Louisville.
All about AROTR Saturday!
The Pixies stop by Louisville Palace
All about AROTR Friday!
Bike rentals to be offered at the the Parklands
Starlight, Indiana is hosting the annual Strawberry Festival this Memorial Day weekend!
ReSurfaced is back!
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Spending a Saturday afternoon tasting beer sound good?
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All about AROTR Thursday!
This is NOT Paramore
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Low Risk / Return investment
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High Risk / Return investment
Since 04/04/11
Following a number of years of in-house testing, our Standard strategy was launched in October 2009. In early 2011, two new strategies were added to our service portfolio to meet the needs of the more conservative and aggressive forex investors.
The Foreign Exchange trading system adopted by RTFX for its managed account service is based on different algorithms developed in-house. These algorithms generate daily transactions on the spot Forex market and more specifically on the EUR/USD and EUR/JPY currency pairs.
RTFX Ltd is a pioneer in the online Foreign Exchange market with a history dating back to 1995 and forms part of a group of strategic partnering companies. RTFX is one of the very few regulated entities licensed to offer managed accounts on the FX market for private individuals. RTFX is licensed and authorised to provide its services throughout Europe.
22nd April, 2015 at 14:21
The first quarter of 2015 marked the beginning of the European Central Bank's Quantitative Easing program and was stunned by the Swiss National Bank's decision to drop its floor on the EUR/CHF. These were arguably the major news headline, in a market dominated by uncertainty and "Currency Wars".
8th April, 2015 at 14:30
his month started on a sour note for both currencies; in fact, , the first week of April has registered a series of pretty significant data misses for the US while the single currency is highly under pressure with massive debt repayment deadlines approaching for Greece.
27th March, 2015 at 15:22
On Wednesday 18th March Yellen addressed the post-FOMC news conference communicating the latest update on the Federal Reserve's monetary policy. Here are the most important takeaways from Yellen's speech.


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Photos of Joe and Kevin Jonas, Camilla Belle in LA
The Jonas Brothers Get Ready to Leave on a Jet Plane
by Celebrity
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The eldest Jonas brothers were out and about in LA this week, though Nick stayed out of sight. Joe posed with some fans while his girlfriend Camilla Belle waited in the car. Meanwhile, Kevin went shopping with friends. The boys' 3D movie comes out tomorrow and they are getting ready to spend the weekend surprising fans around the country. ICYMI, we'll be chatting with them aboard their jet on Sunday, so don't forget to leave us your questions here!
Read More Joe JonasKevin JonasCamilla Belle
Joe Jonas
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italianblonde 6 years
I don't see anything wrong with how Joe is dressed. I guess it's true that the most popular celebs are also the most hated..
Joygirl 6 years
Um, the whole dog-in-a-purse thing needs to end....
floppyfish1986 6 years
I actually love their style, at least they have style. They do wear some crazy colors and clothing at times but I think its all on trend and its an expression of their personalities. Plus they're still young!
care0531 6 years
Who is helping dress these guys? If they weren't going through woman like crazy I would think they were gay.
ilanac13 6 years
i agree! i'm tired of them too and i've never been a fan. i hope that their movie does ok but that they just go away!
PensaGrey 6 years
They really need a long absence after this.


text: My story with the "La Peonia" had started much more earlier than I arrived there. High level service was felt even from the emailing with the owners. Antonello was so kind to offer to pick up us from the airport (I was travelling with two children and it was my first time in Sardinia so I was anxious about all... More


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When Dana Pourkomeylian's little sister was born, she was determined that her sister should never have to experience the injustices that she herself had been through. This silent promise to her sister was the start of a political journey that over time took her from involvement in party politics to starting an association for children and youth.
Sofia Lindman, 19, wanted to do something about social inequalities, the stalled gender equality debate and the male-dominated hip hop industry. So she started GeniusRAP – a rap choir for girls!


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Board of Governors Fee Waiver:
The Board of Governors Fee Waiver program is a State financial aid program administered
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Only California residents may apply. This fee waiver waives the enrollment and student center fees portion of your registration.
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Students who received a BOG for 2014-2015 must reapply for the 2015-2016 school year. Summer 2015 is the start of the new year for BOG. If you have completed the 2015-2016 financial aid application (FAFSA or Dream Act), please check myHancock to see if your BOG has been awarded to you.
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Attention Students!! Beginning 2015-16 school year, BOG will be implementing academic standards. These changes may affect your BOG eligibility for 2015-16 school year. Keep checking Allan Hancock's website and/or myHancock financial aid messages/deadlines for updates.
Lacey Hemeon
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"I am getting the hands-on training that I need for my medical assisting certification. Hancock is convenient for me to commute to and is very affordable. The instructors are very helpful and knowledgeable. After this program, I plan on getting either my RN or going on to get my physician assistant license."
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TK Kelly
A native New Yorker, TK Kelly now lives in Los Angeles as a writer and blogger for Tosh.0 on Comedy Central.
He has performed at clubs across the country like Gotham, the Improv, the Comedy Store, and Standup NY, and has written for Comedy Central Studios, Second City, Funny or Die and SportsNet NY.
He co-hosts "Movie Night," a weekly podcast with fellow comedian Dwayne Perkins, and also runs the popular LA standup show, Warp Zone Comedy at the Virgil.
TK Kelly's Upcoming Events
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- Another great All-Stars show 2nite at 8p w/ @Deanofcomedy @ComicMikeV @ryanreiss @marinayfranklin & more! Tix bit.ly/1CNq2Yo Jul 02
- Great lineup 2nite at 7:30p @RyanHamilton, @MacioComedian, @bscottmcfadden, Leonard Ouzts, Marion Grodin! Tix at bit.ly/1Nst8HJ Jun 30
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This Place was not even on yelp! I live just up the block. Pool, beer, and burgers. Play, eat and drink. What more can you ask for


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Gary D'Amato offers news and insights on Wisconsin golf, new technology, courses and instruction
Begay to receive GWAA award
Notah Begay, whose passion, commitment and advocacy for the health and well-being of American Indian youth led to the founding of the Notah Begay III (NB3) Foundation in 2005, has been named recipient of the Golf Writers Association of America's Charles Bartlett Award.
Begay, 39, is half Navajo, one-quarter San Felipe and one-quarter Isleta and is the only full-blooded American Indian to play on the PGA Tour. A four-time Tour winner, he founded the NB3 Foundation to battle the epidemic of childhood and type 2 diabetes and obesity among American Indian children.
He has raised more than $3.23 million through the annual NB3 Foundation Challenge golf event to support the foundation's programs.
The Charles Bartlett Award, named for the first secretary of the GWAA, is given to a professional golfer for his or her unselfish contributions to the betterment of society.
Begay will be honored at the annual GWAA awards dinner on April 4 in Augusta, Ga., along with players of the year Luke Donald, Yani Tseng and Tom Lehman; William D. Richardson Award winner Maj. Dan Rooney; Ben Hogan Award winner Sophie Gustafson; and Jim Murray / ASAP Award winner Brad Faxon.
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What's so good?
By Bri Guy | Jan 18, 2013 | Total plays: 15,075
"Girl I Can't Forget" is a shoegaze track with bouncy guitar play, chill keyboard work and reverbing vocals. In total, the band has released four total tracks (including this one) to thier SoundCloud page.
If you're feeling it, grab The Death Of Pop's songs off SoundCloud or on Bandcamp at "name your price." And be sure to follow them on Facebook as we wait for their next move.


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The supply of housing inventory exceeds demand. Buyers have the advantage over sellers due to the abundance of homes on the market, with homes often selling at reduced prices. Price drops are common as sellers compete to find buyers.
Rent prices are relatively stable, and availability is good. If your yearly income is around $45,000, you can afford to rent in this market. Rent prices have increased by 13% over the past 3 months. This is 20% lower than the state average of $1,322 and 116% lower than the country average of $2,388.
Trend data coming soon.
|For Sale: 165
|New: 26
|Recently Sold: N/A
|Reduced: 69
|Average Home Price
|Average Sold Price
|Property Records: 10,685
|Foreclosed: N/A
The average home price in 84403 is $273,189. The average home price per square foot in 84403 is $90 and about 0% of all homes in 84403 sold in the last 6 months. For 84403 home values, real estate prices, and city market trends, research the 10,685 property records or search our 0 recently sold or 165 homes for sale listings. The listings and properties in 84403 are only a part of the 750,485 properties and 15,247 homes for sale in Utah. Because of this, the average home price and average home value of 84403 also influence the average home price $421,977 and average sale price $176,618 of Utah. Listing counts, 84403 home prices and home values in 84403 are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.
|Median Age
|Median Household Income


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Rock Valley has 4 schools. Some of the best schools in Rock Valley are Rock Valley Jr-Sr High School with a GreatSchools rating of 6/10 and a parent rating of 5/5 stars, and Rock Valley Elementary School with a GreatSchools rating of 4/10 and a parent rating of 5/5 stars. The average GreatSchools rating for Rock Valley public schools is 5/10, with an average student/teacher ratio of 14:1.
School data provided by National Center for Education Statistics, Maponics, and GreatSchools. Intended for reference only. GreatSchools Ratings compare a schools test performance to statewide results. To verify enrollment eligibility, contact the school or district directly.
Good values on homes are still available, as the number of homes listed for sale is greater than the number of homes being sold. Great deals can be found by determined buyers.
Not enough data to determine market type. Consult a local REALTOR® for up-to-date market summaries
Trend data coming soon.
Trend data coming soon.
|For Sale: 2
|New: N/A
|Recently Sold: N/A
|Reduced: 1
|Average Home Price
|Average Sold Price
|Property Records: 24
|Foreclosed: N/A
The average home price in Rock Valley is $269,000, which is 52.9% higher than the average sold price in Rock Valley ($175,882) . The average home price per square foot in Rock Valley is $137 and about 0% of all homes in Rock Valley sold in the last 6 months. For Rock Valley home values, real estate prices, and city market trends, research the 24 property records or search our 0 recently sold or 2 homes for sale listings. The listings and properties in Rock Valley are only a part of the 1,062,336 properties and 16,196 homes for sale in Iowa. Because of this, the average home price and average home value of Rock Valley also influence the average home price $125,211 and average sale price $160,326 of Iowa. Listing counts, Rock Valley home prices and home values in Rock Valley are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.
|Median Age
|Median Household Income


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Devonport House
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
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Historical Traveler Reviews Devonport House London
Great Weekend Value
We stayed at Devonport House for 3 nights in mid-February 2005. Weekend rates were excellent value and though the hotel itself was not exactly exciting, our room was bright, clean, and spacious with an unusually comfortable bed - all very nice after tramping round exhibitions all day. Set just a bit off the main drag, it has the advantage of being unusually quiet for London while being really well located for the local sights, a range of eating opportunities and transport into Docklands or central London.
Apart from a fiddly arrangement with the TV and a remote which only worked if we werent (remote that is!), facilities in-room were fine and we particularly liked the lockable wardrobe idea for your valuables.
Reception service was brisk and efficient on check-in (though a touch on the `chilly' side) but took a little too long on checking out but they were training a new member of staff.
Being exceptionally lazy, we never took breakfast and there were far too many other options locally for us to bother with the hotel bar/dining, so can't comment on these. If you like Thai, nearby Kum Luang gets a big thumbs up from us!
Overall, an excellent value base for exploring London.
We have just returned from a weekend break staying at Devonport House. The location in Greenwich is perfect with easy access on public transport into London for sightseeing. The hotel was very comfortable and the food was excellent. We could not find any faults at all with the standard of accomodation and friendliness of the staff. We will definitely be returning to this hotel for our next visit to London.
Really enjoyed my relaxing stay here once I found the place ( or rather once I found the entrance, which is not that easy under cover of darkness!).
Everthing was top class- breakfast, rooms, staff.
Great weekend value and I hope to return.
Location, location, location!
Although primarily used as a conference centre, my boyfriend and I spent the weekend at Devonport House to fully explore Greenwich and found it to be a clean, friendly and very pleasant hotel. The rooms are comfortable, well-equiped and decorated to a high standard, much nicer than the usual 'chain hotel' garish carpet and curtain prints! Location-wise, Devonport House cannot be beaten... very close to everything you would want to visit (Greenwich park, Cutty Sark, Maritime museum, observatory, market, shops, restaurants etc.) but noise isn't a concern as when we returned to the hotel late on Saturday night we didn't hear a peep out of the local revellers! (Of which we were two...) My only tip would be to ask for a fan in the room on a hot day as the windows didn't open more than a crack.
Nice place, excellent location but.....
.......there might be a problem.
I tend to judge any Hotel against my favourite Hotel chain, Travel Inn. For easy booking, spacious clean rooms, ease of parking and no mini bar hassle checkout the no frills chain takes some beating.
I used Devonport House when on business in central London and wanted to try it for possible use for a later leisure trip when I would be coming by car with my family.
It is actually a conference centre where you can book their surplus rooms as a hotel. It is situated in the old Seaman's Hospital nurses home next to the old Naval school, adjacent to the centre of Greenwich.
The old building has been well refurbished and the rooms are bright, modern and the one I had was spacious enough with a lovely bathroom. The situation was excellent being yards from the Greenwich Park ( I walked up to the Observatory before breakfast) and within an easy walk to the Docklands light railway which connects to the tube -it took me 35 minutes into Holborn in London. Opposite there is a real ale pub and plenty of restaurants a few yards away. Outside they have parking for 60 cars.
Devonport House was quiet, comfortable, clean well situated. I was particularly impressed with how they has completely modernised the old building and was delighted find free internet access in the coffee room and a proper table and chair to work at in my room.
If I had to pay the rack rate I would be back at the Travel Inn but at �79 including breakfast for one through Active Hotels it passed the Travel Inn test. Had I booked through laterooms the week before I could have got it for �59!
So what of the sourhead who wrote the negative review. Well I looked at the 24 hour conference rates (which is obviously their core business) and they were a little pricey, but it is obviously a smart place and someone has invested a lot of money in it. The breakfast room wasn't large and the tables were mostly (but not exclusively) laid out in rows to accommodate a lot of people who which to talk together as you would get at a conference. The buffet breakfast set up was typical of a 4* hotel, I liked the fact that you could help yourself to the coffee, but I could imagine that if a whole conference of people descended to breakfast at the same time there could be a queue. When I was there it was quite pleasant with people taking their breakfast eat at the tables outside.
So full marks to Devonport House. So what might the problem be ?
Well Shhhh.... don't tell anyone about it or it will get fully booked, the deals through Active Hotels and Laterooms will go and I will have to go back to the Travel Inn.
Loved the devonport
excellent hotel. stayed here august, 2003
only one problem no air conditioning.
Great weekend rates!
We have visited the Devonport House a number of times and found it fantastic value for money at weekends. We have always found the rooms clean, spacious and bright, with good facilities. The staff have been polite and friendly and the breakfast perfectly adequate. It has provided a great base for exploring Greenwich but we have also used it for central London as well. Highly recommended!
Absolutely average for a conference centre
If you want to stay in a conference centre with canteen style breakfast and offhand staff but pay the price of a 4 star hotel (which is what it claims to be on the website), then Devonport House is for you.
Overpriced for the standard of room and service, although the location is good, central in Greenwich and a stone's throw from the park.
A winner in Greenwich!
This gets my vote for best new hotel in 2003! The Devonport opened in January 2003 as a conference center located in the old Naval College in Greenwich. However, it also offers B&B in high quality rooms for as low as �59 per room per night! It's location in Greenwich can't be beat: about three blocks from the light rail (10 minutes to Canary Wharf and 20 to the City) and only a stone's throw (literally) from the Maratime Museum. Greenwich is a tourist magnet by itself and it is very convenient by rail to London Bridge Station( 15 minutes). So I can't recommend highly enough this location (and hotel) as an alternative base for London. Just to round things out I have some downsides: No airconditioning in the otherwise all-mod-cons room can be a disadantage in the summer and the check out is posted as 9am (though I don't think they're tight about it.)
Perfect in every way
the devonport house hotel was perfect from walking through the door,reception was clean and spacious and manned by some very nice polite staff, the rooms were absolutly spotless,with enough space to loose a small country, the breakfast menu was extensive with a wide range of food to satisfy all tastes,polite,helpful waiting staff combined to make a very pleasent atmosphere, the admirals bar was excellent with a wide range of drinks and an even wider range of whiskeys,quiet surroundings and a beer garden in which to wind down after taking in londons vast attractions,so many infact i would not have known where to start if it was not for the help of Tash,the bar maid,whose intimate knowledge of london and underground made for a grade A holiday,highly recommended hotel!!
TripAdvisor Reviews Devonport House London
Travel Blogs from London
High Culture
... my favourite songs from that era turn out to be theirs. And in fact, my phone's ringtone is "Waterloo Sunset." The show was a sort of biography of the band, and the songs fitted in well with the plot, and were well-performed. The finale was "Lola" and the whole audience was standing and clapping and dancing - fantastic! The theatre was full, which surprised me, and although many people were older than us, there were quite a few younger ...
London: Third time's a charm
... for his stay so I took a train over to London early on Wednesday to spend the day in town before he came in. I had the day to myself until Rob joined me in the evening so I saw the changing of the guard in the morning and then spent the early afternoon reading The Secret Life of Bees in Hyde Park near Buckingham Palace (I've gotten to read so many books that have been on my list for years!). Even though it was pretty brisk, there were so many people out running ...
Super Bowl Funday(!!!!)
I hope everyone is enjoying the Super Bowl this fine Sunday evening. I know I am. I am just so anxious to see the turnout. Patriots, Seahawks?? AH the suspense is just killing me.. Just kidding. I had someone from England ask me yesterday who was playing in the game... Had no idea. My grandma would cringe with my lack of knowledge in football haha.
Anyways, I spent most of the weekend traipsing around London. We left on Friday morning to go ...
There's nowhere else like London.
... triptych, which was cool. Then we listened to another guide talk about a Turner (of Turner Prize fame). Then we caught up with her again to listen to her talk about some Pre-Raphaelite paintings. I don't usually like guided tours of galleries, but these guides were great, mostly they gave us some back-stories and showed us some interesting parts of the paintings. I just hate it when they get all interpretive.
We have another week in London. YAY!
We're going on a job hunt...
... In fact the only two things I have ruled out are stripping and 'standing on the corner'.
But I've still got time. A whole week and a lot can happen in a week. So I am not stressing yet.
I have put in an application to work at Wicked. They were looking so if I get that, ...


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Golden Brooks - BET Black Girls Rock CoverGirl Style Stage on the Red Carpet at New Jersey Performing Arts Center - Arrivals - Newark, NJ, United States - Saturday 26th October 2013
The Rolling Stones are set to celebrate their long career as a band next year (2016) with their first exhibition at London's Saatchi Gallery.
The star makes his superhero debut in the upcoming movie.
The 'Game of Thrones' actress has given some hope to Jon Snow's legions of fans.
The video for Kendrick Lamar's latest single 'Alright' was shot in San Francisco, California.
'Secret In Their Eyes' is the upcoming re-boot of the 2009 Argentine Academy Award winning movie of the same name.
Disclosure go sci-fi thriller on us in the new video for their single 'Holding On', featuring the vocals of Gregory Porter.
The new movie mixes old and new territory.
The male stripper sequel hit US theatres today (July 1st) and stars Channing Tatum, Matt Bomer, and Joe Manganiello.


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Publications (19)146.41 Total impact
- SourceAvailable from: Kai Zacharowski
Article: Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts[Show abstract] [Hide abstract]
ABSTRACT: It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an association with the risk of disease development. This study aims to examine the response associated with genetic variations of TLR4, the receptor for bacterial LPS, and a central intracellular signal transducer (TIRAP/Mal) on cytokine release and for susceptibility and course of severe hospital acquired infections in distinct patient populations. Three intensive care units in tertiary care university hospitals in Greece and Germany participated. 375 and 415 postoperative patients and 159 patients with ventilator associated pneumonia (VAP) were included. TLR4 and TIRAP/Mal polymorphisms in 375 general surgical patients were associated with risk of infection, clinical course and outcome. In two prospective studies, 415 patients following cardiac surgery and 159 patients with newly diagnosed VAP predominantly caused by Gram-negative bacteria were studied for cytokine levels in-vivo and after ex-vivo monocyte stimulation and clinical course. Patients simultaneously carrying polymorphisms in TIRAP/Mal and TLR4 and patients homozygous for the TIRAP/Mal SNP had a significantly higher risk of severe infections after surgery (odds ratio (OR) 5.5; confidence interval (CI): 1.34 - 22.64; P = 0.02 and OR: 7.3; CI: 1.89 - 28.50; P < 0.01 respectively). Additionally we found significantly lower circulating cytokine levels in double-mutant individuals with ventilator associated pneumonia and reduced cytokine production in an ex-vivo monocyte stimulation assay, but this difference was not apparent in TIRAP/Mal-homozygous patients. In cardiac surgery patients without infection, the cytokine release profiles were not changed when comparing different genotypes. Carriers of mutations in sequential components of the TLR signaling system may have an increased risk for severe infections. Patients with this genotype showed a decrease in cytokine release when infected which was not apparent in patients with sterile inflammation following cardiac surgery.Critical care (London, England) 06/2010; 14(3):R103. DOI:10.1186/cc9047
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ABSTRACT: Calgranulins are a family of powerful chemoattractants, which have been implicated as biomarkers in inflammatory diseases. To determine how different respiratory diseases affect the expression of calgranulins, we measured the expression of S100A8/A9 and S100A12 in bronchoalveolar lavage fluid (BALF) of acute respiratory distress syndrome (ARDS) patients and healthy volunteers by ELISA. Analysis of calgranulin expression revealed a high level of S100A12 in the lavages of patients suffering from ARDS compared to controls (p<0.001). Based on the hypothesis that the increased expression of S100A12 relative to the S100A8/A9 heterodimer was a characteristic of respiratory diseases with neutrophilic inflammation, we measured calgranulin expression in BALF of cystic fibrosis (CF) patients. Despite similarly elevated levels of S100A8/A9, S100A12 was significantly higher in ARDS compared to CF BALF (p<0.001). The differential expression of calgranulins was unique for inflammatory markers, as an array of cytokines did not differ between CF and ARDS patients. Since ARDS is an acute event and CF a chronic inflammation with acute exacerbations, we compared calgranulin expression in sputum obtained from CF and patients with chronic obstructive lung disease (COPD). Levels of S100A12 and S100A8/9 were elevated in CF sputum compared to COPD sputum, but the ratio of S100A12 to S100A8/A9 was similar in COPD and CF and reflected more closely than seen in healthy controls. The results indicate that the regulation of human calgranulin expression and the ratio of S100A8/A9 to S100A12 may provide important insights in the mechanism of respiratory inflammation.Respiratory Medicine 04/2008; 102(4):567-73. DOI:10.1016/j.rmed.2007.11.011 · 2.92 Impact Factor
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ABSTRACT: The family of the toll-like receptors comprises a minimum of 10 members identified in humans so far. These transmembrane receptors act as important signaling intermediates between the host and the invading pathogens. The following review describes the complexities encountered by researchers studying toll-like receptor (TLR) expression changes during bacterial infections. Mutations in some of the TLRs, most prominently TLR4 and TLR2, have been associated with increased susceptibility to infectious diseases. While it is tempting to correct the phenotypic effect of such mutations, in vitro and in vivo research has shown that TLR activity and function comprises a complex regulatory network. Heterodimer formation, synergy, and cross-tolerance have previously been described. More recently, interdependence of TLR2 and TLR4 expression has been identified. In addition, TLR expression follows a specific timeline that may be dependent on the invading pathogen. Lastly, mutations in invading pathogens have been shown to alter the expression profile of TLR2 and TLR4, indicating that therapies against bacterial pathogens will have to target multiple TLRs. Despite the complexities involved in TLR function, the significant progress made in our understanding of the role these proteins play in human diseases also indicates their potential value as therapeutic agents.Current pharmaceutical design 02/2006; 12(32):4185-93. DOI:10.2174/138161206778743547 · 3.29 Impact Factor
Article: Differential involvement of toll-like receptors 2 and 4 in the host response to acute respiratory infections with wild-type and mutant Haemophilus influenzae strains.[Show abstract] [Hide abstract]
ABSTRACT: We used a mouse model of acute respiratory infections to investigate the role of Toll-like receptor 2 (TLR2) and TLR4 in the host response to Haemophilus influenzae. Acute aerosol exposures to wild-type strains of H. influenzae showed that TLR4 function was essential for TNF-alpha induction, neutrophil influx, and bacterial clearance. To determine how lipooligosaccharide (LOS) modifications would affect the role of TLR4 in inducing the host response, we used acute infections with an H. influenzae strain expressing a mutation in the htrB gene. This mutant strain expresses an LOS subunit with decreased acylation. In response to H. influenzae htrB infection, tumor necrosis factor alpha (TNF-alpha) secretion remained TLR4 dependent. But the decrease in LOS acylation made the neutrophil influx and the bacterial clearance also dependent on TLR2, as shown by the decreased host response elicited in TLR2 knockout mice compared to C57BL/6 mice. A subsequent analysis of TLR2 and TLR4 gene expression by quantitative PCR indicated that TLR4 function induces TLR2 expression and vice versa. These results indicate that some changes in the LOS subunit of H. influenzae can favor signaling through non-TLR4 receptors, such as TLR2. The results also indicate a close interaction between TLR4 and TLR2 that tightly regulates the expression of both receptors.Infection and Immunity 05/2005; 73(4):2075-82. DOI:10.1128/IAI.73.4.2075-2082.2005 · 4.16 Impact Factor
Article: Toll-like receptor 2 represses nonpilus adhesin-induced signaling in acute infections with the Pseudomonas aeruginosa pilA mutant.[Show abstract] [Hide abstract]
ABSTRACT: Expression of pili and associated proteins is an important means of host invasion by bacterial pathogens. Recent evidence has suggested that the binding of Pseudomonas aeruginosa through nonpilus adhesins may also be important in respiratory diseases, since adhesins bind mucins. Using wild-type C57BL/6 and TLR2KO mice, we compared the induction levels of the host response to P. aeruginosa that either expressed pili or lacked pilus expression due to a mutation in the structural gene pilA. In C57BL/6 mice, deletion of pili led to a decreased immune response, evidenced by a lower secretion of cytokines and a lack of neutrophil chemotaxis. By contrast, the P. aeruginosa pilA mutant induced a hyperresponsive phenotype in TLR2KO mice. TLR2KO mice showed an increased number of neutrophils in lavage fluid compared to the levels seen when either mouse strain was exposed to wild-type P. aeruginosa. Further analysis indicated that the increased neutrophil influx was associated with an increased expression of calgranulins, possibly through an induction of Toll-like receptor 4 (TLR4) expression. The hyperresponsive phenotype of TLR2KO mice exposed to the P. aeruginosa pilA mutant was associated with TLR4 induction and indicated that nonpilus adhesin-induced signaling was repressed by TLR2 function and, if not blocked by the host, could induce airway hyperresponsiveness.Infection and Immunity 09/2004; 72(8):4561-9. DOI:10.1128/IAI.72.8.4561-4569.2004 · 4.16 Impact Factor
Article: Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses.[Show abstract] [Hide abstract]
ABSTRACT: While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.Infection and Immunity 04/2004; 72(3):1828-31. DOI:10.1128/IAI.72.3.1828-1831.2004 · 4.16 Impact Factor
- Shock 01/2004; 21(Supplement):19. DOI:10.1097/00024382-200403001-00076 · 2.73 Impact Factor
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ABSTRACT: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with heterogeneous pathological features, disease courses and genetical backgrounds. In this study we determined whether genetic variants of toll-like receptor (TLR) 4, which confer substantial differences in the inflammation elicited by bacterial lipopolysaccharide, are related to the development of MS. We found no differences in the frequencies of the cosegregating TLR4 Asp299Gly and Thr399Ile polymorphisms between Austrian MS patients (11.6%) and age-matched controls (13.7%). Furthermore, we could not detect any influence of these mutations on clinical parameters and serum levels of soluble adhesion molecules of MS patients. Our data indicate that these TLR4 polymorphisms have no influence on the incidence, progression and inflammatory parameters of MS.Tissue Antigens 02/2003; 61(1):85-8. DOI:10.1034/j.1399-0039.2003.610108.x · 2.35 Impact Factor
Article: Association between the Asp299Gly Polymorphisms in the Toll-like Receptor 4 and Premature Births in the Finnish Population[Show abstract] [Hide abstract]
ABSTRACT: Premature birth causes significant health risks of the neonate and increases the cost for neonatal care. Urogenital infection, often caused by Gram-negative bacteria, is a known risk factor. Toll-like receptor-4 (TLR4) is the major endotoxin-signaling receptor and as such is crucial for the initiation of the innate immune response against Gram-negative bacteria. Recently, a variant in the human TLR4 gene was shown to be associated with impaired receptor function and an increased likelihood of Gram-negative sepsis. In the present study, we determined whether the same polymorphism in TLR4 gene is associated with an increased risk for premature birth. We analyzed genotypes for a Finnish study population consisting of a total of 351 term infants and 440 premature infants (gestational age <35 wk; 282 singletons, 158 multiples) and 94 mothers for the presence of the TLR4 polymorphisms Asp299Gly and Thr399Ile. These polymorphisms were in linkage disequilibrium. The 299Gly allele frequencies were 10.6% (93 of 880) in premature infants and 8.3% (58 of 72) in term infants. Excluding multiple pregnancies that often result in premature births, 23.8% (67 of 282) of premature infants and 24.2% (15 of 62) of the mothers of premature infants compared with 15.9% (55 of 345) of term infants and 15.0% (3 of 20) of the mothers delivering at term were carriers of the TLR4 variant. The frequencies of 299Gly allele and Asp/Gly or Gly/Gly genotype carrier status in premature singleton infants were higher than in term singleton infants (p = 0.024, p = 0.028, respectively) or in premature multiples (p = 0.036, p = 0.044, respectively). According to the present results an allelic variation in the TLR4 receptor was associated with increased risk of premature birth.Pediatric Research 10/2002; 52(3):373-6. DOI:10.1203/00006450-200209000-00011 · 2.84 Impact Factor
Article: Toll-Like Receptor 4 (TLR4)-Deficient Murine Macrophage Cell Line as an In Vitro Assay System To Show TLR4-Independent Signaling of Bacteroides fragilis Lipopolysaccharide[Show abstract] [Hide abstract]
ABSTRACT: Bacterial lipopolysaccharides (LPS) activate cells of innate immunity, such as macrophages, by stimulating signaling through toll-like receptor 4 (TLR4). We and others have hypothesized that LPS derived from different bacterial species may function through TLR4-independent mechanisms. To test this hypothesis, we have generated using a nonviral transformation procedure a bone marrow-derived macrophage cell line called 10ScNCr/23 from mouse strain C57BL/10ScNCr. This mouse strain has a deletion of the TLR4 locus, causing the mouse strain to be nonresponsive to stimulation by LPS from Escherichia coli while responding normally to other bacterial substrates, such as lipoteichoic acid (LTA) from Staphylococcus aureus, which signal TLR4 independently. Stimulation with LTA induces five- and sixfold increases in 10ScNCr/23 cell line tumor necrosis factor alpha and macrophage inflammatory protein-2 (MIP-2) secretion, but no increases in either cytokine were found when cells were stimulated with E. coli LPS. Bacteroides fragilis-derived LPS, however, can effectively stimulate MIP-2 expression in the absence of functional TLR4 in the 10ScNCr/23 cell line. This gives rise to the notion that LPS from some bacterial species will utilize alternative receptors to stimulate the innate immune response.Infection and Immunity 10/2002; 70(9):4892-6. DOI:10.1128/IAI.70.9.4892-4896.2002 · 4.16 Impact Factor
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ABSTRACT: The ability to mount a prominent inflammatory response to bacterial pathogens confers an advantage in innate immune defense but may signal an increased risk of atherosclerosis. We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial lipopolysaccharide are related to the development of atherosclerosis. As part of the five-year follow-up in the Bruneck (Italy) Study, we screened 810 persons in the study cohort for the TLR4 polymorphisms Asp299Gly and Thr399Ile. The extent and progression of carotid atherosclerosis were assessed by high-resolution duplex ultrasonography. As compared with subjects with wild-type TLR4, the 55 subjects with the Asp299Gly TLR4 allele had lower levels of certain proinflammatory cytokines, acute-phase reactants, and soluble adhesion molecules, such as interleukin-6 and fibrinogen. Although these subjects were found to be more susceptible to severe bacterial infections, they had a lower risk of carotid atherosclerosis (odds ratio, 0.54; 95 percent confidence interval, 0.32 to 0.98; P=0.05) and a smaller intima-media thickness in the common carotid artery (regression coefficient, -0.07; 95 percent confidence interval, -0.12 to -0.02; P=0.01). The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminishes the inflammatory response to gram-negative pathogens, is associated with a decreased risk of atherosclerosis. This finding is consistent with the hypothesis that innate immunity may play a part in atherogenesis.New England Journal of Medicine 08/2002; 347(3):185-92. DOI:10.1056/NEJMoa012673 · 54.42 Impact Factor
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ABSTRACT: Septic shock remains a significant health concern worldwide, and despite progress in understanding the physiological and molecular basis of septic shock, the high mortality rate of patients with septic shock remains unchanged. We recently identified a common polymorphism in toll-like receptor 4 (TLR4) that is associated with hyporesponsiveness to inhaled endotoxin or lipopolysaccharide in humans. Since TLR4 is a major receptor for lipopolysaccharide in mammals and gram-negative bacteria are the prevalent pathogen associated with septic shock, we investigated whether these specific TLR4 alleles are associated with a predisposition to a more severe disease outcome for patients with septic shock. We genotyped 91 patients with septic shock as well as 73 healthy blood donor controls for the presence of the TLR4 Asp299Gly and TLR4 Thr399Ile mutations. We found the TLR4 Asp299Gly allele exclusively in patients with septic shock (P =.05). Furthermore, patients with septic shock with the TLR4 Asp299Gly/Thr399Ile alleles had a higher prevalence of gram-negative infections. Mutations in the TLR4 receptor may predispose people to develop septic shock with gram-negative microorganisms.Archives of Internal Medicine 06/2002; 162(9):1028-32. DOI:10.1001/archinte.162.9.1028 · 13.25 Impact Factor
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ABSTRACT: For several decades, the mouse strains C3H/HeJ and C57BL/10ScNCr have been known to be hyporesponsive to endotoxin or lipopolysaccharide (LPS). Recently, mutations in Toll-like receptor (TLR) 4 have been shown to underlie this aberrant response to LPS. To further determine the relationship between TLR4 and responsiveness to LPS, we genotyped 18 strains of mice for TLR4 and evaluated the physiological and biological responses of these strains to inhaled LPS. Of the 18 strains tested, 6 were wild type for TLR4 and 12 had mutations in TLR4. Of those strains with TLR4 mutations, nine had mutations in highly conserved residues. Among the strains wild type for TLR4, the inflammatory response in the airway induced by inhalation of LPS showed a phenotype ranging from very sensitive (DBA/2) to hyporesponsive (C57BL/6). A broad spectrum of airway hyperreactivity after inhalation of LPS was also observed among strains wild type for TLR4. Although the TLR4 mutant strains C3H/HeJ and C57BL/10ScNCr were phenotypically distinct from the other strains with mutations in the TLR4 gene, the other strains with mutations for TLR4 demonstrated a broad distribution in their physiological and biological responses to inhaled LPS. The results of our study indicate that although certain TLR4 mutations can be linked to a change in the LPS response phenotype, additional genes are clearly involved in determining the physiological and biological responses to inhaled LPS in mammals.AJP Lung Cellular and Molecular Physiology 12/2001; 281(5):L1106-14. · 4.04 Impact Factor
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ABSTRACT: For several decades, the mouse strains C3H/HeJ and C57BL/10ScNCr have been known to be hyporesponsive to endotoxin or lipopolysaccharide (LPS). Recently, mutations in Toll-like receptor (TLR) 4 have been shown to underlie this aberrant response to LPS. To further determine the relationship between TLR4 and responsiveness to LPS, we genotyped 18 strains of mice for TLR4 and evaluated the physiological and biological responses of these strains to inhaled LPS. Of the 18 strains tested, 6 were wild type for TLR4 and 12 had mutations in TLR4. Of those strains with TLR4 mutations, nine had mutations in highly conserved residues. Among the strains wild type for TLR4, the inflammatory response in the airway induced by inhalation of LPS showed a phenotype ranging from very sensitive (DBA/2) to hyporesponsive (C57BL/6). A broad spectrum of airway hyperreactivity after inhalation of LPS was also observed among strains wild type for TLR4. Although the TLR4 mutant strains C3H/HeJ and C57BL/ 10ScNCr were phenotypically distinct from the other strains with mutations in the TLR4 gene, the other strains with mutations for TLR4 demonstrated a broad distribution in their physiological and biological responses to inhaled LPS. The results of our study indicate that although certain TLR4 mutations can be linked to a change in the LPS response phenotype, additional genes are clearly involved in determining the physiological and biological responses to inhaled LPS in mammals.AJP Lung Cellular and Molecular Physiology 11/2001; 281(29):1106-1114. · 4.04 Impact Factor
- BioTechniques 08/2001; 31(1):22-4. · 2.75 Impact Factor
Article: Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation[Show abstract] [Hide abstract]
ABSTRACT: Lipopolysaccharide (LPS) has been implicated in the pathogenesis of graft-versus-host disease (GVHD). The toll-like receptor (TLR)-4 has been recently identified as a major receptor for LPS. Mutations of TLR4 have been associated with LPS hyporesponsiveness. We hypothesized that TLR4 mutations reduce the risk of acute GVHD in allogeneic marrow transplant recipients. In a preliminary study to determine the frequency of TLR4 mutations and their possible association with GVHD, we tested 237 patients and their HLA-identical sibling donors for 2 TLR4 polymorphisms. All patients received methotrexate and cyclosporine for GVHD prophylaxis. One or more mutants were detected in 10.8% of patients and 10.6% of donors. Multivariable logistic regression models were used to analyze the association between TLR4 mutations and probability (1-sided) of GVHD. The odds ratio (adjusted for advanced disease, total body irradiation dose, and patient age) for development of grades II to IV GVHD when a mutation was present in the recipient was 0.63 (95% confidence interval [CI], 0.25-1.60; P = .16). When a mutation was present in the donor, the adjusted odds ratio was 0.88 (95% CI, 0.36-2.17; P = .40). When a mutation was present in both recipient and donor, the odds ratio was 0.72 (95% CI, 0.22-2.32; P = .29). Among 24 patients with TLR4 mutations in either donor or recipient, 4 (16.7%) developed gram-negative bacteremia. Among 213 patients without mutations, 14 (6.6%) developed gram-negative bacteremia (P = .09). The data indicate that a reduced risk of acute GVHD is associated with TLR4 mutations and that TLR4 mutations may increase the risk for gram-negative bacteremia. However, these associations are not statistically significant in recipients of HLA-matched sibling marrow transplants who are prophylactically treated for infections and GVHD. A much larger study population would be needed to confirm the role of LPS in the pathogenesis of GVHD in humans.Biology of Blood and Marrow Transplantation 02/2001; 7(7):384-7. DOI:10.1053/bbmt.2001.v7.pm11529488 · 3.35 Impact Factor
Article: A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection.[Show abstract] [Hide abstract]
ABSTRACT: The toll-like receptor 2 (TLR2) has gained importance as a major mammalian receptor for lipoproteins derived from the cell wall of a variety of bacteria, such as Borrelia burgdorferi, Treponema pallidum, and Mycoplasma fermentans. We were interested in identifying mutations in the TLR2 gene that might prove to be associated with altered susceptibility to septic shock. We performed a mutation screen of the TLR2 gene using single-stranded conformational polymorphism in 110 normal, healthy study subjects and detected an Arg753Gln mutation in three individuals. No other missense mutations were detected in the TLR2 open reading frame. Functional studies demonstrate that the Arg753Gln polymorphism, in comparison to the wild-type TLR2 gene, is significantly less responsive to bacterial peptides derived from B. burgdorferi and T. pallidum. In a septic shock population, the Arg753Gln TLR2 polymorphism occurred in 2 out of 91 septic patients. More importantly, both of the subjects with the TLR2 Arg753Gln polymorphism had staphylococcal infections. These findings suggest that a mutation in the TLR2 gene may predispose individuals to life-threatening bacterial infections.Infection and Immunity 12/2000; 68(11):6398-401. DOI:10.1128/IAI.68.11.6398-6401.2000 · 4.16 Impact Factor
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ABSTRACT: There is much variability between individuals in the response to inhaled toxins, but it is not known why certain people develop disease when challenged with environmental agents and others remain healthy. To address this, we investigated whether TLR4 (encoding the toll-like receptor-4), which has been shown to affect lipopolysaccharide (LPS) responsiveness in mice, underlies the variability in airway responsiveness to inhaled LPS in humans. Here we show that common, co-segregating missense mutations (Asp299Gly and Thr399Ile) affecting the extracellular domain of the TLR4 receptor are associated with a blunted response to inhaled LPS in humans. Transfection of THP-1 cells demonstrates that the Asp299Gly mutation (but not the Thr399Ile mutation) interrupts TLR4-mediated LPS signalling. Moreover, the wild-type allele of TLR4 rescues the LPS hyporesponsive phenotype in either primary airway epithelial cells or alveolar macrophages obtained from individuals with the TLR4 mutations. Our findings provide the first genetic evidence that common mutations in TLR4 are associated with differences in LPS responsiveness in humans, and demonstrate that gene-sequence changes can alter the ability of the host to respond to environmental stress.Nature Genetics 07/2000; 25(2):187-91. DOI:10.1038/76048 · 29.65 Impact Factor
Top Journals
University of North Carolina at Chapel Hill
North Carolina, United States
- • Thurston Arthritis Research Center
- • Department of Pediatrics
Wake Forest University
Winston-Salem, North Carolina, United States
- Department of Internal Medicine
Wake Forest School of Medicine
Winston-Salem, North Carolina, United States
- • Section of Molecular Medicine
- • Section on Infectious Diseases
University of IowaIowa City, Iowa, United States
Duke University
Durham, North Carolina, United States
- Department of Medicine
Duke University Medical Center
Durham, NC, United States
- Department of Medicine


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4. Laugh away your week's sorrows at the Wonderland Ballroom's Don't Block the Box comedy show Friday. Featured comedians include Last Comic Standing's Aparna Nancherla and DC Improv's Keith Irvin. 7 PM; $2. For more details, click here.
5. As part of the I Love the '90s outdoor-film series, Edward Scissorhands is playing at Rosslyn Gateway Park Friday at dusk. The Johnny Depp/Tim Burton classic is free. For more information about upcoming movies, click here. Want to know about other outdoor-film series in Washington? Check out our roundup here.
6. Friday from 7 to 9, take a look at the work of artists Ryan Hill and Lindsey Raymond at the Civilian Art Projects. Hill's work—organized in an exhibit called SuperFacial—is mostly found images and word associations, while Raymond's Killing Me Softly display shows embroidered and hand-sewn pieces that combine tradition with horror. The show opens at 7; free. Click here for more information.
7. Pulitzer Prize-winning journalists Scott Higham and Sari Horwitz discuss their book, Finding Chandra: A True Washington Murder Mystery—which is based on the 13-part Washington Post series on Chandra Levy's disappearance—at Politics and Prose Saturday at 3:30. Free. For more details, click here.
8. Beautiful Losers, a film directed by Aaron Rose and Joshua Leonard, discusses the graffiti-influenced, DIY visual aesthetic popularized by artists such as Shepard Fairey and Barry McGee. It's at the National Portrait Gallery's McEvoy Auditorium at 3:30 Saturday. The event is free, and no tickets are required. Click here for more information.
9. Famed DJ Will Eastman brings his punk/pop/club/indie Bliss dance night to U Street Music Hall. Guest DJs include VS Wild and Phil Real. Doors open at 10 PM Saturday, and tickets are $10. Get more information here.
10. Sunday is the DC Record Fair at the Black Cat. You can browse through records from more than 30 vendors—plus, DJs Dredd, Fort Knox Five, Alec MacKaye, John Foster, and more will spin. The record-palooza runs from noon to 6, and admission is $2.
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Two of Canada's most exciting strikers will be in action in Saskatoon on August 23, as lightweight veteran Sam "Hands of Stone" Stout and fellow 155-pound standout Shane "Shaolin" Campbell read news >>
Ultimate Fighting Championship (UFC) will make its debut in Saskatoon for the upcoming UFC Fight Night 74 mixed martial arts (MMA) event on FOX Sports 1, locked and loaded for Aug. 23, 2015 inside Sa read news >>
Bellator 138 and UFC Fight Night 69 are in the books, and the featherweight division had a big weekend for top-tier talent.Filed under: Bellator, MMA Rankings, News, UFC, WSOF read news >>
UFC Fight Night 74 Saskatoon fight card and start times for August 23, 2015, in Saskatoon, Saskatchewan, Canada. read news >>
The UFC® makes its debut in the province of Saskatchewan on Sunday, August 23 at the SaskTel Centre in Saskatoon. UFC FIGHT NIGHT™: HOLLOWAY vs. OLIVEIRA will feature a five-round main read news >>
Ultimate Fighting Championship (UFC) is bringing its brand of mixed martial arts (MMA) to the SaskTel Centre in Saskatoon, Saskatchewan, Canada, for the first time ever on Aug. 23, 2015, featuring a read news >>
A high stakes five-round featherweight affair between Max Holloway and Charles Oliveira will headline the UFC's debut event in Saskatoon, Sask., Canada, on Aug. 23.Filed under: News, UFC read news >>
MEXICO CITY – Patrick Williams knew he accomplished something special at Saturday's UFC 188 event, but it took a post-fight chat with UFC President Dana White to confirm it.Filed under: Featured Vide read news >>
Check out the results of the four televised preliminary card bouts on FX, including the flyweight clash between Henry Cejudo and Chico Camus. UFC 188 came up empty on finishes in the opening three fi read news >>
MEXICO CITY – A couple right hands, one very tight choke, and a total of 23 seconds from start to finish. That's how Patrick Williams got his first UFC victory, putting Alejandro Perez to sleep with read news >>
British heavyweight Chi Lewis-Parry (6-1, 2 KO's) is chasing a showdown with Pat 'HD' Barry (16-6-1, 10 KO's) under the GLORY banner. The one-time LA Lakers tryout is doing all he can to provoke Barr read news >>
Glory 23 is official for August 7, and we've got news on the main event, right here. This past weekend saw Glory putting on an excellent show in Glory 22 France; it also saw the announcement of what read news >>
With Joseph Valtellini vacating the GLORY welterweight title due to post-concussion syndrome, GLORY announced a welterweight battle between Nieky Holzken and Raymond Daniels for the vacant title at G read news >>
GLORY is hitting Sin City and bringing a title fight with it. Dutch knockout artist Nieky Holzken will take on the always-exciting Raymond Daniels for the welterweight title in the main event of GLOR read news >>
UFC contenders Andrei Arlovski and John Dodson are riding high after their wins at May 23's UFC 187 event in Las Vegas. The Team Jackson-Winkeljohn MMA standouts apparently wasted no time getting bac read news >>


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MADGE: Community feedback is the key to stop gang crime
By Molly Trotter/KTVL.COM
TALENT, Ore. -- Jackson County Gang Task Force is holding its last community forum to address gang related problems in county.
Law enforcement officials are expressing the importance of community feedback.
"The most important thing is getting that communication engagement. Some have had really good turnouts, some not as much and people should voice their opinions on where the communication is and what the gang issues are," said Lt. Brett Johnson, a member of the Medford Area Drug and Gang Enforcement Team.
These forums have been scheduled across Jackson County to explore the perceptions community members and parents have about local gang activities.
The primary reason for gathering information is to determine how community members and parents view gang activity and how they believe gangs affect their community.
Phoenix and Talent are the last two cities in the county to have the forum.
The forum will take place Dec. 12 at the Talent Library, 101 Home St., starting at 5:30 p.m.
Business News
Applications for US jobless aid rise to still-low 281,000
WASHINGTON (AP) -- More people sought U.S. unemployment benefits last week, but the level of applications is still low and points to an improving job market.
Consumer Info
WEST PALM BEACH, FL -- (Marketwired) -- 03/21/14 --
Companies that pride themselves on being eco-friendly may have conflicted
ideas between marketing with ad specialties and maintaining their green
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LOS ANGELES (AP) -- It's magic versus Arnold at the nation's movie theaters this holiday weekend.
Get This
SHELBY TOWNSHIP, Mich. (AP) -- Some Detroit-area cops are dealing with some real animals.
Science/Tech News
PHILADELPHIA (AP) -- Philadelphia has legalized and plans to tax Airbnb and other short-term rentals ahead of Pope Francis' visit in September and next year's Democratic National Convention.
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Tasty TopicsWe've all seen News10's Trish Glose tasting food on West Coast Flavors. Now she has more space to talk about food and drink!
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Portland, you don't know how good you have it! This is an awesome venue on so many levels. My wife and I saw an amazing solo show with Rhett Miler. If this show was in LA, it...
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Waterfront Bike Path to Kelly Point Park
Sauvie Island - Wapato Greenway State Park
Ponytail Falls and Triple Falls Loop Hike
Portland, you don't know how good you have it! This is an awesome venue on so many levels. My wife and I saw an amazing solo show with Rhett Miler. If this show was in LA, it would be packed, the tickets would be twice as much, and the beers would be far more than $5. The sound here is...
Went by for a couple of drinks on a Saturday before dinner. Nice place and decent selection, but they were obsessed with IDs for everyone. We're in our mid 30s and still needed to show ID for everything. We even had to get a stupid stamp on the hand to verify age just for sitting outside.
Well planned space with good acoustics and a warm, friendly ambience. We also tried their food before the show started.
Great experience at an affordable price.
Truly the best music venue in Portland. Great acts in a small, accessible stage area which is mostly standing, but with seating upstairs. A good selection of beers in the studio, along with simple eats next door in the restaurant. A friendly place to meet the bands before and after their sets.
My wife and I tried to go on Ausgust 23, but to no avail. The host did not accept our drivers licenses, demanding our passport, which hadn' t happened in any of the music venues we' ve been on our 3 week trip in the West coast. We are on our mid THIRTIES! I was sooo desappointed. Really poor treatment...
After a small mishap in ticket purchase, Kevin was incredibly gracious, stopping at nothing to ensure that I felt heard and taken care of. I look forward to visiting again.
My husband and I love seeing live music, and we loved the atmosphere and excellent acoustics of this great find. Good beer selection and we saw 2 awesome bands for only a $15 cover! Highly recommended. We'll come back next time we are in town.
Love this place...great music...great food...great drinks...great time. A super fun venue in all respects. It doesnt get much better than this!!
Took the train down to Portland from Vancouver (about 8 hrs) to check out Matthew Good solo and acoustic at this place that I had never heard of. It is definitely one of the best venues I have ever been to see a concert. It is a relatively small venue which makes for a great atmosphere and intimate feeling with...
this music club has been a great discovery, a few concerts in two years, including some great plays like Shearwater and Husky in 2012 + Vieux Farka Touré and Tezeta Band in 2013. Great concerts and great musicians, if you like music and the new proposals do not miss the less known names... Visit www.mississipistudios.com for the updated calendar of...
Register now for free — and start getting automatic notification of new reviews, responding to traveler feedback, adding new photos to your listing and much more.


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Samoa wing Alesana Tuilagi cannot wait to face New Zealand at home in Apia on July 8, saying his team will give 120 percent in the game.
Northampton Saints have announced that Luke Eves will be heading to the club over the next few months on a short-term deal.
Toulouse prop Census Johnston has been named in the Samoa squad to face New Zealand despite previously retiring.
The Chiefs have confirmed their coaching staff for the next two Super Rugby seasons.
Racing 92 lock Tomas Lavanini has committed to the new Argentina Super Rugby franchise until at least the end of 2018.
This week we will mostly be concerning ourselves with World Rugby's need to act to preserve the integrity of the Rugby World Cup.
Relive all the drama from the clash in Sydney
The best pictures from Wellington.
Twenty years on from their historic World Cup victory, the Springbok squad reunited at Ellis Park in Johannesburg.
A tribute to Norm Berryman, who's passed away.
Relive all the drama from the clash in SydneyPhoto galleries home
It is time for our weekly round-up of who has their name in lights at the moment... and who is making the headlines for the wrong reasons.
Two superb semi-finals captivated audiences on Saturday. Here are the winners and losers from those games in Wellington and Sydney.
A new name will be added to the Super Rugby trophy following Saturday's final between the Hurricanes and Highlanders in Wellington.
Heyneke Meyer has named eight uncapped players in his preliminary squad for the Rugby Championship with 49 players included in total.


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Drink between: 2007 - 2019 (Add My Dates)
741 Tasting Notes
604 Tasting Notes
Jonah's Whale Beach.
69 Bynya Road, Whale Beach, Sydney, Australia 2107
Decanted 30 minutes.
Mid-yellow translucent gold.
Mild nose of beeswax and honey then white stone fruit from the glass. Smells like Vouvray.
Medium body, medium tart citrus flavours to the fore. Underripe lemon/ lime, underlying honey provides a hint of sugar though this is not the focus. Finishes with mid palate tang, mineral cut and lemony lingering.
Really unfortunate. I love Huet with all my heart and their wines can be almost immortal. This one sadly had oxidized a little bit and wasn't showing it's best. Acids were still firm and the texture was surreal - perhaps in full bottles it's still showing as it should. If you have one to spare, I'd recommend testing it soon to see how your own cellar is treating this glorious wine.
Probably didn't show as well as it should have? Developed yellow, more like a riesling of the same age. Hard kero-like nose points to age but suggests 20 years, not 12. Lemon citrus and bitter lemon to taste, barely wine-like. I wonder if this was not well stored prior to my purchase?
Blind tasted and wrongly guessed a Chablis. Zesty nose with lemon and grapefruit rind. Extreme bitter lemon flavor with massive acidity, rapier like. Perhaps better on the second night where it became a focused light beam, sharp but warm...
Served right after opening. Nose suspicious of dry mushrooms. But mouth is straight , linear, fresh without flaw. Fine and mineral. Just a hint of honey and perhaps tilleul to show shy clues of chenin. Very good, but I think it has passed his colors, even if the structure is still very strongh. Matching very well pork rillettes.


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Email Alerts
Column: Wi-Fi makes cities more dangerous - great news for security resellers!
London is lagging behind Manchester, Amsterdam, Paris and Stockholm in mobile cybercrime, according to a new risk analysis report commissioned by Norton. But a new initiative involving the GSMA and the Wireless Broadband Alliance (WBA) could see Lond... Opinion
Stordis picks up UK network start-up Gnodal
High performance storage and networking distie Stordis has signed a deal with Bristol-based switching start-up Gnodal to help the fledgling company take its first steps in the channel. Gnodal, which was set up five years ago, specialises in 10 and 40... News
Daisy recruits new reseller support team
Business comms provider Daisy Group has formed a new product specialist partner support team to help underpin growth in the breadth of its product lines. Sitting behind its channel-centric account and sales teams, with specialisms in data, hosted IP ... News
Mobile management demand driving managed services
Coping with consumerisation offers managed service providers a much greater opportunity in the short term than cloud computing. Those selling managed services products are being inundated with customer demands for solutions that can manage tablets a... News
Riverbed gets technical with VAR programme enhancements
In a move billed as a response to its increasing breadth of product lines, Riverbed is to shake up its Partner Network programme to put the emphasis firmly on technical expertise. The key selling point of the revamped programme is the addition of a n... News
Azlan services team to drive VAR annuity biz
C2000 enterprise wingman Azlan has today announced the formation of a services team designed to help resellers target more services-based annuity revenues. Headed up by IBM and Services Business Unit director Kevin Markwick, who clambered aboard the ... News
Cisco piles into video acquisition game with $5bn offer for NDS
Just hours after rival Avaya swooped on Radvision, Cisco has piled in with a $5bn (£3.18bn) purchase of its own in the shape of video software and content security solutions developer NDS Group Ltd from current owners Permira and Rupert Murdoch... News
Avaya extends video options with Radvision acquisition
Avaya has bolstered its videoconferencing capabilities with the acquisition of Radvision which provides the technology to provide video to mobile devices. With the consumerisation trend firmly in mind the telecommunications vendor has made the acqui... News
Column: It's in the public interest
In the public interest, this column spear phished Piers Morgan, so we could help put the record straight and prove his innocence of all the disgraceful charges of phone hacking. Opinion
Start-up offers Cisco $1 for WebEx
Private equity-backed meeting platform software specialist SalesCrunch has made an apparently genuine offer to Cisco to buy its WebEx web-conferencing service for a single dollar (63p), plus 15% equity in the business. SalesCrunch reckons that in lig... Opinion


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3 Ways Sequestration Is Taking a Toll on Struggling Americans
Congress recently sprang into action to save air travelers from flight delays brought on by sequestration. But for the millions of Americans who can't afford to get on a plane, they have yet to repeal devastating cuts to important programs for struggling families, seniors, and children—leaving us all to wonder where our nation's most vulnerable fit into Congress's priorities. Here are three programs where sequestration is already taking a toll on struggling Americans.
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Hot answers tagged contacts-group
Contacts Click the New Group button: "+" with 2 people. Give it a name and click ok. Go back to My Contacts (or whichever grouping is appropriate) and select users. On the right, click Groups and select the group to add to. Compose an email and use the group name in the To field
When you add a contact to a group you choose the email address that you want to add to it and not the actual contact. When the contact are displayed in the group list you will have the email you have chosen and +x depending on how many other email address the person has, however, when you send an email to that group it will be only sent to the email ...
In your compose window, simply start typing the name of the contact group in the Cc field. When you see the contact group you want to use, just click on it (or use the arrow keys to highlight it then press enter). All of the email addresses for the contacts in that group will be added to the field. Of course, this works for To and Bcc as well.
Please follow these steps to be able see your groups and to add/remove/modify group properties: 1- If you are in Outlook, then click on the down arrow beside the Outlook logo on the top left. Alternatively, go to the People page here and sign in if you aren't already signed in. 2- You should see something along these lines: Now, your groups and ...
Only top voted, non community-wiki answers of a minimum length are eligible


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Dr Stephen Johnston gave an impassioned presentation at the 2013 ZAAQ conference hosted by Australia Zoo illustrating ways zoos, researchers and wildlife workers can save the koala in a collective community effort. The role of Queensland wildlife parks in the fine scale genetic management of captive and fragmented koala populations – Stephen Johnston, A Mucci, W Ellis, M Pyne…read more
The role of Queensland wildlife parks in the fine scale genetic management of captive and fragmented koala populations
Koalas' conservation status downgraded
Koalas' conservation status downgraded February 26, 2014 Tony Moore brisbanetimes.com.au senior reporter Experts have recommended Queensland's koala population be downgraded to 'vulnerable'. Photo: Ian Waldie Fauna experts have recommended the conservation status of the koala in Queensland be downgraded and broadened to "vulnerable" throughout the state. However, the recommendation is yet to be accepted by Environment Minister…read more
Koalas on the outer live life differently
Koalas on the outer live life differently Friday, 13 September 2013 Katie Silver – ABC Koalas living in the eastern parts of the range rely on the moisture of their leaves for water(Source: Josh Berglund/Flickr) Related Stories Koalas reject rehab field of dreams, Science Online, 20 Feb 2013 Koalas added to threatened species list, Science…read more
Eurobodalla Koala Project breakthrough
Koala project breakthrough By EMILY BARTON Nov. 8, 2013, 10:19 a.m. Keith Joliffe and volunteer Daniel Baumann check for eucalypt on a recent field survey as part of the Eurobodalla Koala Project. Koalas may be back in the Eurobodalla Shire sooner rather than later. The Eurobodalla Koala Project, lead by Keith Joliffe, has been going since 2010…read more
Adam France is krafting for the koala kause
K is for koalas Our cosy and beloved – yet disappearing and nearly dead friends. Koalas are too cute to be true, but when turned into bloodied and smashed roadkill they loose points on presentation. Humans have helped kill almost 90% of the population and it's time we think about saving them. Crafting for their…read more
Koala population under dire threat
Koala population under dire threat Jade Kidd | 12:01am August 18, 2013 KOALAS could become extinct on the Gold Coast soon after after the city council's relocation program ends in June next year, according to the Australian Koala Foundation. Foundation chief executive officer Deborah Tabart said hundreds of koalas in the area would be left in…read more
Koalas' future now up to council
Koalas' future 'now up to council' 9th Aug 2013 11:55 AM The image of the mother and baby koalas Natalie Richardson distributed.Contributed WILDLIFE conservationists say Henderson Park's koala population is far from safe – despite the developer putting a hold on bulldozing and offering to sell the land to the council. Natalie Richardson said it…read more
Scientific questions simmer over koala plot data
A long-running issue relating to the reliability of vegetation data is causing major tensions in North Hawks Nest. Planners, landowners and even scientists are now in dispute over the location of missing plots of feed trees in an undeveloped area of core koala habitat. QUESTIONS FOR ECO-PRO/ KHAALYD BROWN 3 concerned scientists, Graeme Wells, Anthony…read more
The Koala Land Report
The objective of this report is to explore ways of creating a sustainable future for koalas on the Koala Coast, South East Queensland, Australia. For the purpose of this report, the Koala Coast includes the local government areas of Moreton, Redland, Gold Coast, Sunshine Coast, Brisbane, Ipswich and Logan. As indicated by its name, this…read more
Report Preview : Lock Dogs Up At Night
Image Source : Mark Gerada The Koala Coast koala populations dropped by 68% in the ten years leading up to 2008. According to the Department of Environment and Resource Management's Koala Coast Koala Population Report 2010, a comprehensive survey of the koala population showed that it dropped by more than 50% between 2005 and…read more
Lesbian koala sex revelation
The animal kingdom is ripe with examples of society's sex and gender norms being challenged in a range of species. Science has a long history of imposing a human centric filter, ignoring the fluidity and diversity of animal sexuality in the natural world. It appears that koalas can be added to that list, more precisely female koalas in captivity,…read more
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koalas on reddit
- X-post from r/Australia: Barry the camera operatorsubmitted by DoppelSechser [link] [comment]
- Touching Photos Show A Baby Koala Clinging To Mom While She Has Surgerysubmitted by StarFuryG7 [link] [2 comments]
- All Mine!submitted by d_kreindler [link] [comment]
- epic koala. (/r/itookapicture/ /u/bigroly)submitted by badchung [link] [4 comments]
- Baby koala bear hugs mum during life-saving surgerysubmitted by beary-important [link] [3 comments]
- Archer's All Grown Upsubmitted by d_kreindler [link] [1 comment]
- The Koala Project: studying how Chlamydia antibiotics affect the Koala gut microbiomesubmitted by staticscream [link] [comment]
- Best place in Australia to hold and take a picture with a koala?Hello friends! American here about to venture to Asia/Oceania for a while, and I would love to be able to see a koala outside of a zoo. Does anyone have suggestions for good koala sanctuaries or places where I could take a picture with a koala? I'm willing to pay/donate for the privilege. I also obviously want the place to be a legitimate establishment
- Canned Koalasubmitted by duranger4 [link] [19 comments]
- Koala after this weekend's storms in Otway, Victoriasubmitted by Deathisfatal [link] [1 comment]


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J. J. G. McCue
Born: December 25th, 1913
Died: February 2011
J.J. Gerald McCue grew up in West Orange, NJ and graduated high school at age 16. Shortly after, he was employed by Bell Labs in Greenwich Village working as a technical assistant in vacuum tube development.
Aftre two years at Bell Labs, McCue enrolled at Harvard and graduated cum laude with a degree in Physics in 1936. He received his Ph.D. from Cornell in 1940 and began teaching at Hamilton College, where he remained for four years. After this time, he was employed by the MIT Rad Lab.
In 1945, McCue became an Associate Professor of Physics at Smith College and joined the MIT's Lincoln Laboratory in 1949.


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Auto Enthusiast Day presented by Nitto Tire
- Auto, Boat & Air
- 2000 E Gene Autry Way, Anaheim, CA, 92806
ALPFA OC Holiday Mixer & Toy Drive sponsored by the Disneyland Resort
ALPFA Orange County Chapter
Saturday, December 8, 2012 from 7:00 PM to 10:00 PM (PST)
We've had such a fantastic year!
Come celebrate with us in Downtown Disney at the wonderful Tortilla Jo's with 50 other ALPFA friends. Help us make a child's Christmas a little more magical as we donate the proceeds of our annual toy drive to Cops 4 Kids, an Anaheim based charity.
The premier Orange County organization for developing the leadership skills of Latino business professionals, ALPFA OC is dedicated to enhancing opportunities for Latinos and building leadership and career skills. Visit us at: http://orangecounty.alpfa.org
Join over 600 Orange County professionals and student members and discover the ALPFA business leader in you!
ALPFA is celebrating its 41st anniversary with over 40 professional chapters and 112 student chapters, ALPFA impacts the lives of over 23,000 Latino business professionals and students. www.alpfa.org
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Eric Ray
An Oakland, Ca. native and a University Of Southern California graduate, Eric began his journalism career in the magazine business and got his first break at In Touch Weekly magazine where he worked as a field reporter and quickly learned the trade of celebrity entertainment and gossip. While there, Eric's beat was any and all things Britney Spears and is credited with breaking stories surrounding Britney during her public meltdown back in 2007.
By then, Eric knew he had one it took to be one the best celebrity reporters in the business and took his skills to the freelance market, where he's worked with just about every magazine on the newsstands. The fearless reporter is now a daily contributor to HollywoodLife.com and continues to deliver countless exclusive material, specifically his coverage of the on-going love saga between Chris Brown and Rihanna.
Eric is an avid runner and feels crappy if he's not in the gym six days a week. He resides in the Miracle Mile district of Los Angeles.
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On June 26, history was made when the Supreme Court ruled to legalize same sex marriage in all 50 states, and Caitlyn Jenner couldn't be happier. But… Read Article ▶
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Caitlyn Jenner's on a crusade to look her best at the 2015 ESPY Awards on July 15. HollywoodLife.com has EXCLUSIVELY learned that she wants to feel… Read Article ▶
Caitlyn Jenner's Dream Is To Be A 'Video Vixen' In Kanye West's Next Music Video7 days ago 8
Move over, music video girls -- there's a new woman in town! Caitlyn Jenner wants to experience the life of a 'video vixen' and is asking Kanye West… Read Article ▶
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Kanye West got a little flack for dozing off during a 'Frozen' show on North West's second birthday. HollywoodLife.com has EXCLUSIVELY learned that… Read Article ▶
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Karrueche Tran now believes her relationship with Chris Brown was doomed from the start. HollywoodLife.com has EXCLUSIVELY learned that when they… Read Article ▶
Chris Brown Upset Karrueche Tran Doesn't Thank Him For Lifestyle He Gave Her2 weeks ago 40
Is a 'thank you' in order? Chris Brown is furious at ex Karrueche Tran for biting the hand that gave her a career. The rapper is so mad all he wants… Read Article ▶
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Caitlyn will NEVER forget June 1 -- the day she finally revealed herself as a woman on the cover of 'Vanity Fair.' She's telling her friends she… Read Article ▶
Chris Brown Is Completely 'Miserable' Without Karrueche Tran & 'Jealous' Of Tyson Beckford1 month ago 6
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