text: Malaria Journal - Latest Articles http://www.malariajournal.com The latest research articles published by Malaria Journal 2015-07-01T12:00:00Z Resistance of infection by <it>Plasmodium vivax</it> to chloroquine in Bolivia Background: Chloroquine (CQ) over three days plus primaquine (PQ) for seven days is the treatment of choice of infections by Plasmodium vivax in Bolivia, where 95% of the cases of malaria are attributed to this species. The aim of this study was to evaluate the therapeutic efficacy of CQ in this setting. Methods: Patients in the Amazon region of northern Bolivia, were included in the study from May to November 2011 and the therapeutic efficacy of CQ was evaluated over a 28-day follow-up period. Patients with P. vivax mono-infection received 25 mg/Kg body weight of CQ over three days. The concentrations of CQ + desethylchloroquine (DCQ) in blood were determined at days 7 and 28 of follow up; at follow-up and on the day of treatment failure was administered PQ. Results: One hundred patients fulfilled the inclusion criteria, two were lost to follow up and another two were later excluded for protocol violation. Of the 96 patients who completed the follow up 10 showed TF; one presented continued parasitaemia until day 7 of follow up, three on day 21 and six on day 28 of follow up. The geometric mean of CQ + DCQ on day 7 was 321.7 ng/ml (range 197–535 ng/ml). In six patients with TF the CQ + DCQ concentrations in blood on the day of TF were >100 ng/ml. The rate of resistance was 6.5%. Conclusion: The present study demonstrates the presence of resistance to CQ in the treatment of malaria by P. vivax in the Amazon region of Bolivia. New clinical trials are needed to establish alternative treatments against these parasites in this region of South America. http://www.malariajournal.com/content/14/1/261 Arletta Añez Manuel Moscoso Ángel Laguna Cecilia Garnica Viviana Melgar Mauren Cuba Sonia Gutierrez Carlos Ascaso Malaria Journal 2015, null:261 2015-07-01T12:00:00Z doi:10.1186/s12936-015-0774-4 A standard in vivo protocol is used to estimate Plasmodium vivax resistance to chloroquine in Bolivia. It is useful information to complete the map of P. vivax CQ-resistance in the Americas. /content/figures/s12936-015-0774-4-toc.gif Malaria Journal 1475-2875 ${item.volume} 261 2015-07-01T12:00:00Z XML Prevalence of malaria parasitaemia in school children from two districts of Ghana earmarked for indoor residual spraying: a cross-sectional study Background: Indoor residual spraying (IRS) is considered a valuable transmission control measure against malaria but exact efficacy data are not available for many epidemiological settings. This study was conducted to determine indicators for malaria epidemiology and transmission among school children as baseline assessment before IRS implementation in Ghana. Methods: A cross-sectional study was conducted in Adansi South District of the Ashanti Region and Wa West District of the Upper West Region of Ghana. Malarial parasitaemia and anaemia were determined in pupils between the ages of 2 and 14 years from Early Childhood Development Centres and primary schools. Plasmodium falciparum parasitaemia was detected by light microscopy. Results: Out of 1,649 pupils who were enrolled at participating schools, 684 were positive for plasmodia resulting in a baseline parasitaemia prevalence of 41.5%. Parasite rate was similar in the two districts (42.0% in Adansi South and 40.7% in Wa West), but differed across the nine sentinel schools ranging from 21 to 63% (p < 0.001). The mean haemoglobin concentration was 11.3 g/dl [standard deviation (SD) ±2.1]. Pupils who had moderate to mild anaemia (7.0–10.9 g/dl) constituted 41.7% of the study sample. Conclusion: The burden of parasitaemia, malaria and anaemia is a major public health problem among school children in rural Ghana with extensive heterogeneity between schools and warrants further investment in intervention measures. http://www.malariajournal.com/content/14/1/260 Nimako Sarpong Ellis Owusu-Dabo Benno Kreuels Julius Fobil Sylvester Segbaya Frank Amoyaw Andreas Hahn Thomas Kruppa Jürgen May Malaria Journal 2015, null:260 2015-06-25T00:00:00Z doi:10.1186/s12936-015-0772-6 Results of a baseline malaria survey among school children in Ghana. The authors report that 50% of children are infected with P. falciparum, with high rates of moderate anaemia and evidence for heterogeneity in malaria indices. /content/figures/s12936-015-0772-6-toc.gif Malaria Journal 1475-2875 ${item.volume} 260 2015-06-25T00:00:00Z XML 'A bite before bed': exposure to malaria vectors outside the times of net use in the highlands of western Kenya Background: The human population in the highlands of Nyanza Province, western Kenya, is subject to sporadic epidemics of Plasmodium falciparum. Indoor residual spraying (IRS) and long-lasting insecticide treated nets (LLINs) are used widely in this area. These interventions are most effective when Anopheles rest and feed indoors and when biting occurs at times when individuals use LLINs. It is therefore important to test the current assumption of vector feeding preferences, and late night feeding times, in order to estimate the extent to which LLINs protect the inhabitants from vector bites. Methods: Mosquito collections were made for six consecutive nights each month between June 2011 and May 2012. CDC light-traps were set next to occupied LLINs inside and outside randomly selected houses and emptied hourly. The net usage of residents, their hours of house entry and exit and times of sleeping were recorded and the individual hourly exposure to vectors indoors and outdoors was calculated. Using these data, the true protective efficacy of nets (P*), for this population was estimated, and compared between genders, age groups and from month to month. Results: Primary vector species (Anopheles funestus s.l. and Anopheles arabiensis) were more likely to feed indoors but the secondary vector Anopheles coustani demonstrated exophagic behaviour (p < 0.05). A rise in vector biting activity was recorded at 19:30 outdoors and 18:30 indoors. Individuals using LLINs experienced a moderate reduction in their overall exposure to malaria vectors from 1.3 to 0.47 bites per night. The P* for the population over the study period was calculated as 51% and varied significantly with age and season (p < 0.01). Conclusions: In the present study, LLINs offered the local population partial protection against malaria vector bites. It is likely that P* would be estimated to be greater if the overall suppression of the local vector population due to widespread community net use could be taken into account. However, the overlap of early biting habit of vectors and human activity in this region indicates that additional methods of vector control are required to limit transmission. Regular surveillance of both vector behaviour and domestic human-behaviour patterns would assist the planning of future control interventions in this region. http://www.malariajournal.com/content/14/1/259 Mary Cooke Sam Kahindi Robin Oriango Chrispin Owaga Elizabeth Ayoma Danspaid Mabuka Dennis Nyangau Lucy Abel Elizabeth Atieno Stephen Awuor Chris Drakeley Jonathan Cox Jennifer Stevenson Malaria Journal 2015, null:259 2015-06-25T00:00:00Z doi:10.1186/s12936-015-0766-4 LLINs offered the local population only a partial protection against malaria vector bites. The overlap of early biting habit of vectors and human activity indicates that additional methods of vector control are required to limit transmission. Regular surveillance of both vector behaviour and domestic human-behaviour patterns are needed in the planning of control interventions in each region. /content/figures/s12936-015-0766-4-toc.gif Malaria Journal 1475-2875 ${item.volume} 259 2015-06-25T00:00:00Z XML Therapeutic efficacy of artemether–lumefantrine for the treatment of uncomplicated <it>Plasmodium falciparum</it> malaria in Enfranze, north-west Ethiopia Background: Plasmodium falciparum accounts for approximately 60% of malaria cases in Ethiopia and artemether–lumefantrine has been used as a first-line treatment for uncomplicated P. falciparum malaria since 2004. The aim of this study was to assess the therapeutic efficacy of artemether–lumefantrine (AL) for the treatment of uncomplicated P. falciparum malaria in north-western Ethiopia. Methods: A 28-day one-arm, prospective evaluation of the clinical and parasitological response to the first-line treatment for uncomplicated P. falciparum malaria was conducted in Enfranze Health Centre in accordance with the 2009 WHO efficacy study guidelines. Patients were treated with a 3-day course of AL and clinical and parasitological parameters were monitored over a 28-day follow-up. All data from recruited patients were imported into an electronic data base and Kaplan–Meier survival analysis was used for analysing primary [early treatment failures (ETF), late clinical failure (LCF), late parasitological failures (LPF), and adequate clinical and parasitological response (ACPR)] and secondary (PCT, GCT and FCT) outcomes. Results: Eighty patients were enrolled and all of them completed the 28-day follow-up period. The PCR-corrected cure rate was 95.0% (95% CI 87.0–98.4%) and there were two ETF, one LCF and three LPF. Two of the LPF were classified as re infections by PCR. Seventy three point seven five percent, 91.25 and 95% of patients had cleared their parasitaemia by days 1, 2, and 3, respectively, and 75, 91.25 and 96.25% of patients had cleared their fever by days 1, 2, and 3. All patients completely cleared their gametocytes by day 7. Conclusion: The relatively high cure rate, low proportion of patients still positive on day 3 as well as parasite clearance times in this study would indicate no imminent threat of artemisinin resistance development in the region. However, the threat of spreading or de novo development of artemisinin resistance warrants regular monitoring of drug efficacy throughout the region. http://www.malariajournal.com/content/14/1/258 Gebeyaw Getnet Abebe Fola Agersew Alemu Sisay Getie Hans-Peter Fuehrer Harald Noedl Malaria Journal 2015, null:258 2015-06-24T00:00:00Z doi:10.1186/s12936-015-0775-3 Therapeutic efficacy of artemether-lumefantrine (AL) for the treatment of uncomplicated falciparum malaria was assessed in north-western Ethiopia. Eighty patients were enrolled and all of them completed the 28-day follow-up period. Parasite clearance times in this study indicate no imminent threat of artemisinin resistance in the region. /content/figures/s12936-015-0775-3-toc.gif Malaria Journal 1475-2875 ${item.volume} 258 2015-06-24T00:00:00Z XML Re-imaging malaria in the Philippines: how photovoice can help to re-imagine malaria Background: This paper responds to a recent call for malaria to be re-imagined by: explaining why it needs to be re-imagined; offering one possible way in which this can be done; and describing some of benefits for malaria control when it is. Methods: This study involved conducting a 15-week photovoice project with 44 predominantly ethnically Palawan school-going children in the municipality of Bataraza in the Philippines. The primary aim was to critically examine how facilitating children to take their own pictures of malaria could alter their understanding of it as well as the practices that they then engaged into prevent and treat it.Results and discussionDuring the photovoice process, participants responded to the question, 'what does malaria mean to you?' by photographing multiple versions of malaria. Some of these versions align with biomedical conceptions and mirror common images of: its sources (e.g. mosquitoes); symptoms (e.g. fever); prevention practices (e.g. use of mosquito nets); diagnostic practices (e.g. use Rapid Diagnostic Tests) and treatment practices (e.g. use of anti-malarial drugs). However, in addition to these depictions, participants also took images of malaria that aligned with more local understanding of the body, health and well-being, which are often neglected by health practitioners. In the case of the Palawan, these versions of malaria are structured around the central tenet of balance. Participants therefore photographed themselves and members of their family and community engaging in a number of practices, which are orientated towards restoring and maintaining balance. As well being an effective means to illuminate multiple malarias and the practices that surround them, photovoice also enabled participants to learn new things and significantly, teach these things to others using their images. Conclusion: Photovoice is an effective method for re-imaging malaria. It allowed participants to depict and describe multiple versions of malaria and the practices that they engage in in context. Photovoice also had a potentially transformative effect. It acted as a means for participants and researchers to: visually depict everyday practices; collectively gain a deeper understanding of this doing; and then seek ways in which to make changes in line with this joint understanding. http://www.malariajournal.com/content/14/1/257 Dalia Iskander Malaria Journal 2015, null:257 2015-06-24T00:00:00Z doi:10.1186/s12936-015-0770-8 A very creative use of Photovoice. The study involved a 15-week project with 44 Palawan school-going children in the Philippines. The primary aim was to critically examine how facilitating children to take their own pictures of malaria could alter their understanding of it. /content/figures/s12936-015-0770-8-toc.gif Malaria Journal 1475-2875 ${item.volume} 257 2015-06-24T00:00:00Z XML Human biting activity, spatial–temporal distribution and malaria vector role of <it>Anopheles calderoni</it> in the southwest of Colombia Background: Anopheles calderoni was first recognized in Colombia in 2010 as this species had been misidentified as Anopheles punctimacula due to morphological similarities. An. calderoni is considered a malaria vector in Peru and has been found naturally infected with Plasmodium falciparum in Colombia. However, its biting behaviour, population dynamics and epidemiological importance have not been well described for Colombia. Methods: To assess the contribution of An. calderoni to malaria transmission and its human biting behaviour and spatial/temporal distribution in the southwest of Colombia, human landing catches (HLC) and larval collections were carried out in a cross-sectional, entomological study in 22 localities between 2011 and 2012, and a longitudinal study was performed in the Boca de Prieta locality in Olaya Herrera municipality between July 2012 and June 2013. All mosquitoes determined as An. calderoni were tested by ELISA to establish infection with Plasmodium spp. Results: Larvae of An. calderoni were found in four localities in 12 out of 244 breeding sites inspected. An. calderoni adults were collected in 14 out of 22 localities during the cross-sectional study and represented 41.3% (459 of 1,111) of the collected adult specimens. Other species found were Anopheles albimanus (54.7%), Anopheles apicimacula (2.1%), Anopheles neivai (1.7%), and Anopheles argyritarsis (0.2%). In the localities that reported the highest malaria Annual Parasite Index (>10/1,000 inhabitants) during the year of sampling, An. calderoni was the predominant species (>90% of the specimens collected). In the longitudinal study, 1,528 An. calderoni were collected by HLC with highest biting rates in February, May and June 2013, periods of high precipitation. In general, the species showed a preference to bite outdoors (p < 0.001). In Boca de Prieta, two specimens of An. calderoni were ELISA positive for Plasmodium circumsporozoite protein: one for P. falciparum and one for Plasmodium vivax VK-210. This represents an overall sporozoite rate of 0.1% and an annual entomological inoculation rate of 2.84 infective bites/human/year. Conclusions: This study shows that An. calderoni is a primary malaria vector in the southwest of Colombia. Its observed preference for outdoor biting is a major challenge for malaria control. http://www.malariajournal.com/content/14/1/256 Lorena Orjuela Martha Ahumada Ivonni Avila Sócrates Herrera John Beier Martha Quiñones Malaria Journal 2015, null:256 2015-06-24T00:00:00Z doi:10.1186/s12936-015-0764-6 A nice study on Anopheles calderoni from southwest Colombia, a poorly studied malaria vector. The manuscript provides information on its distribution, biting patterns, seasonal abundance and infectivity rate. /content/figures/s12936-015-0764-6-toc.gif Malaria Journal 1475-2875 ${item.volume} 256 2015-06-24T00:00:00Z XML Modified mosquito landing boxes dispensing transfluthrin provide effective protection against <it>Anopheles arabiensis</it> mosquitoes under simulated outdoor conditions in a semi-field system Background: Efforts to control malaria vectors have primarily focused on scaling-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying. Although highly efficient against indoor-biting and indoor-resting vectors, these interventions have lower impact on outdoor-biting mosquitoes. Innovative vector control tools are required to prevent outdoor human–mosquito contacts. In this work, the potential of spatial repellents, delivered in an active system that requires minimal user compliance, to provide personal protection against exophagic mosquitoes active in the early evening was explored. Methods: A device previously used as an odour-baited lure and kill apparatus, the mosquito landing box (MLB), was modified to dispense the volatile synthetic pyrethroid, transfluthrin, as a spatial repellent. The MLB has an active odour-dispensing mechanism that uses a solar-powered fan and switches on at dusk to provide long duration dispensing of volatile compounds without the need for the user to remember to employ it. Two MLBs were located 5 m from a human volunteer to investigate the repellent effects of a transfluthrin 'bubble' created between the MLBs. Transfluthrin was emanated from polyester strips, hanging inside the MLB odour-dispensing unit. A fully randomized cross-over design was performed in a large, semi-field, screened cage to assess the effect of the repellent against laboratory-reared Anopheles arabiensis mosquitoes under ambient outdoor conditions. The knock-down capacity of the transfluthrin-treated strips was also evaluated at different time points up to 3 weeks after being impregnated to measure duration of efficacy. Results: The protective transfluthrin bubble provided 68.9% protection against An. arabiensis bites under these simulated outdoor conditions. Volatile transfluthrin caused low mortality among mosquitoes in the semi-field system. Transfluthrin-treated strips continued to knock down mosquitoes in laboratory tests, 3 weeks after impregnation, although this effect diminished with time. Conclusion: Modified MLBs can be used as efficient and long-lasting dispensers of volatile spatial repellents such as transfluthrin, thereby providing high levels of protection against outdoor-biting mosquitoes in the peri-domestic space. They have a potential role in combatting outdoor malaria transmission without interfering with effective indoor interventions such as LLINs. http://www.malariajournal.com/content/14/1/255 Marta Andrés Lena Lorenz Edgar Mbeleya Sarah Moore Malaria Journal 2015, null:255 2015-06-24T00:00:00Z doi:10.1186/s12936-015-0762-8 A very original approach/tool for a very timely problem. Reports on the use of modified mosquito landing boxes for dispensing transfluthrin as a spatial repellent for protection against malaria vector bites. This tool could be used for creation of outdoor 'protection bubbles' which targets outdoor biting malaria vectors responsible for residual malaria transmission. /content/figures/s12936-015-0762-8-toc.gif Malaria Journal 1475-2875 ${item.volume} 255 2015-06-24T00:00:00Z XML Preventing malaria transmission by indoor residual spraying in Malawi: grappling with the challenge of uncertain sustainability Background: In the past decade, there has been rapid scale-up of insecticide-based malaria vector control in the context of integrated vector management (IVM) according to World Health Organization recommendations. Endemic countries have deployed indoor residual spraying (IRS) and long-lasting insecticidal nets as hallmark vector control interventions. This paper discusses the successes and continued challenges and the way forward for the IRS programme in Malawi.Case descriptionThe National Malaria Control Programme in Malawi, with its efforts to implement an integrated approach to malaria vector control, was the 'case' for this study. Information sources included all available data and accessible archived documentary records on IRS in Malawi. A methodical assessment of published and unpublished documents was conducted via a literature search of online electronic databases.DiscussionMalawi has implemented IRS as the main malaria transmission-reducing intervention. However, pyrethroid and carbamate resistance in malaria vectors has been detected extensively across the country and has adversely affected the IRS programme. Additionally, IRS activities have been characterized by substantial inherent logistical and technical challenges culminating into missed targets. As a consequence, programmatic IRS operations have been scaled down from seven districts in 2010 to only one district in 2014. The future of the IRS programme in Malawi is uncertain due to limited funding, high cost of alternative insecticides and technical resource challenges being experienced in the country. Conclusions: The availability of a long-lasting formulation of the organophosphate pirimiphos-methyl makes the re-introduction of IRS a possibility and may be a useful approach for the management of pyrethroid resistance. Implementing the IVM strategy, advocating for sustainable domestic funding, including developing an insecticide resistance monitoring and management plan and vector surveillance guidelines will be pivotal in steering entomologic monitoring and future vector control activities in Malawi. http://www.malariajournal.com/content/14/1/254 Emmanuel Chanda Themba Mzilahowa John Chipwanya Shadreck Mulenga Doreen Ali Peter Troell Wilfred Dodoli John Govere John Gimnig Malaria Journal 2015, null:254 2015-06-24T00:00:00Z doi:10.1186/s12936-015-0759-3 Describes in much detail the numerous challenges that Malawi is facing with implementing malaria vector control using insecticides. It is a complete and balanced manuscript that represents the different backgrounds of the authors. It includes a comparison with how neighbouring countries are executing their programmes and ends with the lessons that can be learned from this. /content/figures/s12936-015-0759-3-toc.gif Malaria Journal 1475-2875 ${item.volume} 254 2015-06-24T00:00:00Z XML Optimization of a multi-well colorimetric assay to determine haem species in <it>Plasmodium falciparum</it> in the presence of anti-malarials Background: The activity of several well-known anti-malarials, including chloroquine (CQ), is attributed to their ability to inhibit the formation of haemozoin (Hz) in the malaria parasite. The formation of inert Hz, or malaria pigment, from toxic haem acquired from the host red blood cell of the parasite during haemoglobin digestion represents a pathway essential for parasite survival. Inhibition of this critical pathway therefore remains a desirable target for novel anti-malarials. A recent publication described the results of a haem fractionation assay used to directly determine haemoglobin, free haem and Hz in Plasmodium falciparum inoculated with CQ. CQ was shown to cause a dose-dependent increase in cellular-free haem that was correlated with decreased parasite survival. The method provided valuable information but was limited due to its low throughput and high demand on parasite starting material. Here, this haem fractionation assay has been successfully adapted to a higher throughput method in 24-well plates, significantly reducing lead times and starting material volumes. Methods: All major haem species in P. falciparum trophozoites, isolated through a series of cellular fractionation steps were determined spectrophotometrically in aqueous pyridine (5 % v/v, pH 7.5) as a low spin complex with haematin. Cell counts were determined using a haemocytometer and a rapid novel fluorescent flow cytometry method. Results: A higher throughput haem fractionation assay in 24-well plates, containing at most ten million trophozoites was validated against the original published method using CQ and its robustness was confirmed. It provided a minimum six-fold improvement in productivity and 24-fold reduction in starting material volume. The assay was successfully applied to amodiaquine (AQ), which was shown to inhibit Hz formation, while the antifolate pyrimethamine (PYR) and the mitochondrial electron transporter inhibitor atovaquone (Atov) demonstrated no increase in toxic cellular free haem. Conclusions: This higher throughput cellular haem fractionation assay can easily be applied to novel anti-malarials with a significantly decreased lead time, providing a valuable tool with which to probe the mechanisms of action of both new and established anti-malarials. http://www.malariajournal.com/content/14/1/253 Jill Combrinck Kim Fong Liezl Gibhard Peter Smith David Wright Timothy Egan Malaria Journal 2015, null:253 2015-06-24T00:00:00Z doi:10.1186/s12936-015-0729-9 A modified ´high throughput´ method to sequentially assay three haem species (haemoglobin [Hb], free haem and haemozoin) in isolated trophozoites by spectrophotometric detection of the haem-pyridine complex. Potentially very useful for drug testing, but needs to be validated for this purpose. /content/figures/s12936-015-0729-9-toc.gif Malaria Journal 1475-2875 ${item.volume} 253 2015-06-24T00:00:00Z XML Malaria and the mobile and migrant population in Cambodia: a population movement framework to inform strategies for malaria control and elimination Background: The relationships between human population movement (HPM) and health are a concern at global level. In the case of malaria, those links are crucial in relation to the spread of drug resistant parasites and to the elimination of malaria in the Greater Mekong sub-Region (GMS) and beyond. The mobile and migrant populations (MMP) who are involved in forest related activities are both at high risk of being infected with malaria and at risk of receiving late and sub-standard treatment due to poor access to health services. In Cambodia, in 2012, the National Malaria Control Programme (NMCP) identified, as a key objective, the development of a specific strategy for MMPs in order to address these challenges. A population movement framework (PMF) for malaria was developed and operationalized in order to contribute to this strategy. Methods: A review of the published and unpublished literature was conducted. Based on a synthesis of the results, information was presented and discussed with experienced researchers and programme managers in the Cambodian NMCP and led to the development and refinement of a PMF for malaria. The framework was "tested" for face and content validity with national experts through a workshop approach. Results: In the literature, HPM has been described using various spatial and temporal dimensions both in the context of the spread of anti-malarial drug resistance, and in the context of malaria elimination and previous classifications have categorized MMPs in Cambodia and the GMS through using a number of different criteria. Building on these previous models, the PMF was developed and then refined and populated with in-depth information relevant to Cambodia collected from social science research and field experiences in Cambodia. The framework comprises of the PMF itself, MMP activity profiles and a Malaria Risk Index which is a summation of three related indices: a vulnerability index, an exposure index and an access index which allow a qualitative ranking of malaria risk in the MMP population. Application of currently available data to the framework illustrates that the highest risk population are those highly mobile populations engaged in forest work. Conclusion: This paper describes the process of defining MMPs in Cambodia, identifying the different activities and related risks to appropriately target and tailor interventions to the highest risk groups. The framework has been used to develop more targeted behaviour change and outreach interventions for MMPs in Cambodia and its utility and effectiveness will be evaluated as part of those interventions. http://www.malariajournal.com/content/14/1/252 Philippe Guyant Sara Canavati Nguon Chea Po Ly Maxine Whittaker Arantxa Roca-Feltrer Shunmay Yeung Malaria Journal 2015, null:252 2015-06-20T00:00:00Z doi:10.1186/s12936-015-0773-5 Trying to define mobile populations and target appropriate interventions to them is very important and has been difficult - it is reassuring to see country programmes and partners attempting to do it and this paper might provide guidance to countries on how to conceptualize and intervene in these populations. /content/figures/s12936-015-0773-5-toc.gif Malaria Journal 1475-2875 ${item.volume} 252 2015-06-20T00:00:00Z XML


text:
Town Square
Dewatering after October
Original post made by Anonymous, Another Palo Alto neighborhood, on Nov 1, 2013
Web Link
Comments (5)
a resident of Old Palo Alto
on Nov 1, 2013 at 4:06 pm
This has been going on and off ( mostly on) since 2009-- what an outrageous loss and waste of water. Apparently this water is coming from an aquifer beneath the property that Larry Page is building his compound on.
Question: will Larry Page's house and all its outbuildings and landscaping EVER be completely finished? It has already been nearly five years.
Another question: Once construction is completed, will this pumping of water continue forever after?
a resident of Old Palo Alto
on Nov 6, 2013 at 1:00 pm
Yes, this insanity continues past the legal cutoff. I presume that the City approved a waiver, but who knows? For deep background, read the 2010 article, "Basement groundwater pumping raises concerns - Experts question safety of massive groundwater pumping for basements in Palo Alto." Web Link
a resident of Old Palo Alto
on Nov 6, 2013 at 9:24 pm
It is not the Page project. It is the project at 2121 Bryant. This appears to be another one of the City's capricious enforcement choices.
a resident of Professorville
on Nov 6, 2013 at 9:40 pm
Isn't that all part of Page's compound. If you look at Google Earth you can see that there are four contiguous lots with basements excavated.
a resident of Palo Verde
on Nov 6, 2013 at 10:45 pm
That's why sea level is rising.
(Actually when you pump too much water out, the ground sinks and it just looks like sea level is rising.)
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Lutticken's owner opens Main & Elm in Redwood City
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OK I Changed The Title
By Laura Stec | 24 comments | 1,702 views
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By Cheryl Bac | 0 comments | 864 views
Relay for Life, Menlo Park, August 8
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subset: commoncrawl


text:
Fox Sports LatAm Acquires Rights To Sochi, Rio Olympic Games
Fox Sports LatAm Acquires Rights To Sochi, Rio Olympic Games
NASCAR Fans Defend Confederate Flag at Daytona
Unlock your personal NFL Now stream by signing in to NFL.com
Fox Sports Latin America has acquired rights to the 2014 Winter Olympics in Sochi and the 2016 Summer Games in Rio de Janeiro. Set to begin Olympics coverage on Feb. 7, Fox will broadcast the games across all Spanish-speaking countries in Latin America via television and online services. The broadcast rights were purchased for an undisclosed amount from America Movil, the Mexican telecom outfit owned by Carlos Slim , the world's second-richest man.
NASCAR took a stance on the Confederate flag after last month's South Carolina church massacre. It backed Gov. Nikki Haley's call to remove it from the Statehouse grounds and noted it doesn't allow the flag on anything it sanctions. The series stopped short of banning fans from displaying the flag at its events, but Daytona and 29 other tracks asked fans to refrain from flying them. Not everyone obliged.
Kentucky authorities say two people were killed and three remain missing after the pontoon boat they were riding in hit a barge and capsized in the Ohio River. Louisville Fire Chief Greg Frederick corrected earlier reports that three people were killed and that the boat struck the Clark Memorial Bridge. Frederick said nine people were aboard and that four were rescued after the accident shortly before 10 p.m. Frederick said the fatalities include one adult and one child.
Proud #FutureHive member Meek Mill has nothing but candidly expressed love for Dreams Worth More Than Money collaborator Future. In a recent interview with Angie Martinez, Meek opened up about his current influences — citing Kendrick Lamar and J. Cole as "dope lyricists [and] great rappers," but reserving the true tip of the hat to Dej Loaf, Young Thug, and inarguable rock star of the year Future. In the video for Money standout "Jump Out the Face," Meek and Future take it to the kitchen after a fascinatingly low-key phone call — eventually joining Rick Ross and a slew of others for a song-specific romp through the joys of success and the importance of learning how to effortlessly embrace the style of Marty McFly circa Back to the Future Part III with as much as enviable grace as Future.
Earlier today, Power105 published a news post on a McDonald's employee who was fired after swapping out children's toys in Happy Meals for his mixtape. We wish it was true but unfortunately the site they sourced from, Huzlers, is pure satire. This has been an ongoing stolen Twitter joke for years and will, hopefully, one day be true.
From his fields in Turkey, farmer Huseyin Ozdemir can see Islamist militants digging trenches and planting mines as they ready for battle around the northern Syrian town of Jarablus. Like many villagers along this stretch of Turkey's 900 km border, Ozdemir welcomed the arrival of additional Turkish soldiers to bolster security in recent days but fears the consequences if they cross into Syria and intervene.
Various - New Look Wireless [Day 3]
Various - New Look Wireless REPLAY Day 2
New Look Wireless Festival - Arrested Development - Inner City Performance
New Look Wireless Festival - Arrested Development - Mama's Always on Stage Performance
New Look Wireless Festival - Arrested Development - Interview
New Look Wireless Festival - Ciara - Goodies Performance
Community Episode 1: Ladders
Community Episode 2: Lawnmower Maintenance and Postnatal Care
Community Episode 3: Basic Crisis Room Decorum
Community Episode 4: Queer Studies and Advanced Waxing
Community Episode 5: Laws of Robotics and Party Rights
Community Episode 6: Basic Email Security
Sin City Saints Episode 1: The Fool Monty
Sin City Saints Episode 2: Smoke and Mirrors
Sin City Saints Episode 3: Gone Catfishing
Sin City Saints Episode 4: Mrs. Wu's Tang
Sin City Saints Episode 5: A Basket Full of Rainbows
Sin City Saints Episode 6: You Booze, You Lose


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Dale M
Full time business manager part time programmer for in-house applications only - don't expect any polish!
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Original recipe yields 12 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Ready In
Very delicious cake and so easy to make. I did cut down the chocolate chips and walnuts to 1/2 cup each and that covered the cake nicely. To save time a cake mix can be used with the same great ...
I used to make this cake when my kids were little over 30 years ago and lost the recipe. It is wonderful! I added an additional 8 ounce can of fruit cocktail, drained, in addition to the 15 ou...
If you like fruit and chocolate combined, it's a very good recipe. It is very tasty. I've had alot of mixed reviews. Some people just don't like the taste. But I did, so it got 5 stars. The ...


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Categories: Fetish, Euro + Suggest
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5 months ago
FYI: you can tell when someone's lying when they tell you that feminism is bullshit, then they go on to tell you they're liberal. NO liberal would EVER be anti-feminist. So, that George guy is a straight-up typical right-winger: woman-hating, anti-feminist, & a liar. He's basing what he thinks feminism is on what the Republican Propaganda Channel (a.k.a. Fox News) has told him it is. Again, the ONLY cancer on our society is fake, phony people like George.
2 years ago
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As for your first sentence, I would expect that from someone who's anti-woman. And, the only people that I've known of who are anti-woman are those who ID as "anti-feminst", who also tend to be right-wingers. And, as far as ad hominems, that's your initial statement to a f*cking "T". Apparently, I know enough about you to be able to safely say that I hope NO woman EVER gets with you & if one does, may God have mercy on her.
5 months ago
Listen man. Being anti femenist is not the same as being anti women. Just because somebody isnt a femenist it doesn't mean that they hate women. I love how you just responded to my comment with ad hominems. You don't even know me. I do respect women. I believe in equal rights. I just don't agree with femenism.. Femenism is not like it was in the past. This third wave Femenism is hypocritical and sexist.
5 months ago
The ONLY cancer on our society I know of is anti-woman, little-dick, angry-boy douchebags like you, who probably live in their parents' basement & jerk to porn because they'll NEVER get laid by ANY women in her right mind. Maybe your mommy should have smacked you around a little more when you were younger to get you to respect women.
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City bans curbside scavenging
Published: Wednesday, June 8, 2011 at 10:18 a.m.
Last Modified: Wednesday, June 8, 2011 at 10:18 a.m.
TUSCALOOSA | Rifling through curbside debris in search of valuables or recyclable goods is now illegal.
The Tuscaloosa City Council unanimously passed an ordinance Tuesday that bans scavenging curbside garbage and debris piles for profit.
Copper and wire hunters who sifted through debris piles caused by the April 27 tornado spawned the vote, but the ban will also affect residents who took aluminum cans from recycle bins or major appliances from the roadside to sell at area scrap metal processors.
If caught, offenders will be required to appear in Municipal Court.
Additionally, the ordinance formally declares as city property any item placed at the curbside for collection by city crews.
Residents who placed the items in front of their home can still retrieve the items before collection, if desired.
— Staff report
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Hearty Roots is a family farm using sustainable practices to grow the freshest, healthiest, tastiest food for our community.
The farm is run by Ben and Lindsey Shute along with a great crew of ambitious and hard-working young farmers. Based on 70 acres in Clermont, NY, the farm currently grows about 25 acres of vegetables per year, cares for a flock of laying hens, and manages another 25 acres of pasture and fallow fields.
Our farming practices
Our goals in farming are to create a product that is healthy for you, for our community, and for the land. That means that we only use natural products that are organically approved in our soil and on our plants; we seek to improve our soil's health and fertility in the long term; we aim to play a positive role in our ecosystem rather than fighting against it; and we pay our workers a fair wage and offer health care.


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'WD My Net AC1300 is performing well'
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isoprene i·so·prene (ī'sə-prēn')
A colorless volatile hydrocarbon that is the naturally occurring basis of isoprenoids and that is used in the production of synthetic rubber.
A colorless, volatile liquid obtained from petroleum or coal tar and occurring naturally in many plants. It is used chiefly to make synthetic rubber. The isoprene in plants occurs in the chloroplasts and is used to build terpenes and other biologically important chemicals. Chemical formula: C5H8.


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Marcus Theatres is warming up for the Oscars with a string of past best-picture winners in January.
First up is "Ben-Hur," the 1959 epic that won a then-record 11 Academy Awards, including best actor for Charlton Heston and best director for William Wyler. ("Titanic" and "The Lord of the Rings: The Return of the King" later tied the record.)
"Ben-Hur" is showing at Marcus' Majestic, Menomonee Falls, North Shore and South Shore cinemas Monday through Thursday.
Other best-picture Oscar winners on Marcus' dance card, showing at those same theaters:
Jan. 13-16: "Out of Africa" (1985), directed by Oscar winner Sydney Pollack, with Meryl Streep and Robert Redford; and "Gladiator" (2000), directed by Ridley Scott, with Oscar winner Russell Crowe.
Jan. 20-23: "Gigi" (1958), directed by Oscar winner Vincente Minnelli, with Leslie Caron and Louis Jourdan; "Driving Miss Daisy" (1989), directed by Bruce Beresford, with Morgan Freeman and Oscar winner Jessica Tandy; and "A Beautiful Mind" (2001), directed by Oscar winner Ron Howard, with Russell Crowe and Oscar winner Jennifer Connelly.
Jan. 27-30: "The Sting" (1973), directed by Oscar winner George Roy Hill, with Robert Redford and Paul Newman; and "The Departed" (2006), directed by Oscar winner Martin Scorsese, with Jack Nicholson and Leonardo DiCaprio.
For showtime info and tickets, go to marcustheatres.com.


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Almonds make up less than 12 percent of the state's total irrigated farmland and use only eight percent of the state's agricultural (not total) water
Water used to grow almonds produces two crops; in addition to the kernels almond hulls are used to feed livestock, in particular dairy cattle.
The Almond Board of California recently released updated Stockpile Management Guidelines
CDFA has issued a zero-tolerance policy for crude fiber violations in almond hulls unless an Almond Hull Quality Assurance Plan is in place. AHPA developed, and ahd available to industry the day the zero-tolerance policy was announced, an Almond Hull Quality Assurance Plan.
Comments are closed.
Almond Hullers & Processors Association
E: email@example.com
© 2012 All Rights Reserved - AHPA
Almond Hullers & Processors Association


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Avanquest Software Games
Legends of Atlantis: Exodus
In Legends of Atlantis: Exodus, players are transported to the mythic continent of Atlantis on the verge of its inevitable destruction.
Midnight Mysteries 4: Haunted Houdini
Midnight Mysteries 4: Haunted Houdini is an adventure game from MumboJumbo.
GoGo's Crazy Bones
GoGo's Crazy Bones brings the toy characters and games to digital life on the Nintendo DS.
From sandy beaches to deep blue seas, explore it all with fun and silly hermit crab characters in Xia-Xia the game.
Pickers Adventures in Rust is a hidden-object game in which players assume the role of a "picker" who collects valuable items to sell or auction off.
Jewel Link Chronicles: Mountains of Madness
Decipher the mystery of the Mountains of Madness in Jewel Link Chronicles: Mountains of Madness.
Prison Tycoon: Alcatraz
This installment in the Prison Tycoon series takes place on the island of Alcatraz.
Hidden Mysteries: Vampire Secrets
Vampire Secrets mixes hidden object gameplay with adventure elements.
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Junior Brain Trainer 2
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Unlikely Suspects
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Becky Brogan: The Institute
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Hidden Mysteries: Salem Secrets - Witch Trials of 1692
This Hidden Mysteries game has you take the role of Constable Hawthorne as you investigate the rumors of witchcraft in the Salem witch trials.


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KAG West , a highway subsidiary of the Kenan Advantage Group , is now seeking Class A CDL Drivers out of Wenatchee, WA .... - Indeed
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Please help us! 3 Ways You Can Help
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text:
LOUISVILLE, Ky. (AP) — Kentucky authorities say two people have been killed and three remain missing after the pontoon boat they were riding in hit the Clark Memorial Bridge and capsized in the Ohio River.
By William James LONDON (Reuters) - Chancellor George Osborne on Sunday said he had found all 12 billion pounds of welfare cuts he needs as part of his plan to balance the budget by 2017/18, speaking ahead of his budget announcement on Wednesday. The budget is Prime Minister David Cameron's Conservatives' clearest chance in almost two decades to remould Britain into a low-tax, small-state economy after an unexpectedly decisive election victory. To meet his target, Osborne says he needs to cut the annual welfare bill by 12 billion pounds ($18.69 billion), make 13 billion pounds of departmental spending reductions, and to raise an extra 5 billion pounds by clamping down on tax evasion and avoidance.
An unmanned Russian cargo ship successfully docked with the International Space Station on Sunday following a string of failed attempts to resupply the orbital laboratory. "The transport cargo ship Progress M-28M has docked with the... Russian segment of the ISS at 10:11am Moscow time (0711 GMT)," the Russian federal space agency (Roscosmos) said in a statement. Russian cosmonauts Gennady Padalka and Mikhail Kornienko and US astronaut Scott Kelly are part of Expedition 44 currently in space, to be joined by three more people later this month.


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Climate Change: The Challenge to All of Us The Challenge to All of Us (Paperback)
|Author: Sean McDonagh
Learn more about Climate Change: The Challenge to All of Us:
Format: Paperback
Publisher: Columbia Press (IE)
Sku: 204193238
Publish Date: 5/23/2007
Dimensions: (in Inches) 8H x 5.25L x 0.5T
Pages: 200
Age Range: NA
See more in Environmental Conservation & Protection
|In this book. Sean McDonagh starts by describing how the threat of climate change comes about and shows the consequences of global warming. He then examines various responses to global warming and faces the question of whether nuclear power is the solution. He outlines a wide range of energy efficiencies and renewables. Finally. McDonagh examines how the churches have responded to this threat to date. Sean McDonagh is a Columban priest who has long been an activist in the field of ecological and environmental matters. He is a lecturer and a prolific author whose books include The Death of Life: The Horror of Extinction (also available from Dufour).


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New Information Released on Fatal Plane Crash
Posted: 12/19/2008 - A new report from the National Transportation Safety Board says an autopsy revealed Ross Franke had morphine, codeine and sleeping pills in his system when he died.
Posted: 12/19/2008 - A new report from the National Transportation Safety Board says an autopsy revealed Ross Franke had morphine, codeine and sleeping pills in his system when he died.
Posted: 12/19/2008 - The shelter will get $25,000 for being the overall winner, and $1,000 for being a weekly vote total winner.
Posted: 12/18/2008 - Wisconsin hospitals now want federal help, because hospital leaders say more charity cases are costing them more money.
Posted: 12/18/2008 - One percent more people are without a job in Wisconsin this year, than last year.
Updated: 12/18/2008 - Matthew R. Wegenke could face seven counts of possession of child pornography.
Posted: 12/18/2008 - The man convicted of murdering a college student decades ago now knows when he will be sentenced.
Updated: 12/18/2008 - Fire investigators met to try and pinpoint what caused a major apartment fire Monday.
Posted: 12/18/2008 - Pleads To Child Neglect
Updated: 12/17/2008 - Wisconsin-based Royal Credit Union is merging with Twin Cities-based Real Financial Credit Union.
Posted: 12/17/2008 - The Clark County Sheriff's Department says 45-year-old Mary C. Frick died in July of an accidental shooting.
Updated: 12/17/2008 - During the holiday season, many people look to help those in need. But some agencies in Eau Claire that help the homeless, like the Beacon House, are operating at full capacity, and the needs are only increasing.
Updated: 12/17/2008 - Winter Storm Watch Borders Eau Claire County
Posted: 12/16/2008 - Now that the snow is piling up and the fire danger is higher, the Eau Claire Fire Department is asking you to adopt a fire hydrant.
Posted: 12/16/2008 - The rules about firewood may be changing in Eau Claire County campgrounds.
Updated: 12/16/2008 - 49-year-old Jeffrey Rodrick of Augusta is accused of beating up and killing Kathryn Padilla
Updated: 12/16/2008 - Sheriff's investigators want you to know about a convicted sex offender moving into the area
Posted: 12/16/2008 - A woman is taken to the hospital after she was thrown from her vehicle, north of Wisconsin Dells, Monday
Posted: 12/16/2008 - Madison Police Say Woman Has Struck Several Times
Updated: 02/04/2009 - A local psychologist gives us some coping mechanisms to deal with today's economy
Updated: 12/15/2008 - On Monday, the court found probable cause for 53-year-old Randy Wolter to go to trial.
Posted: 12/15/2008 - Travel agents say the grim economic situation has slowed down the travel industry, and now many cruise lines and resorts are offering cheap fares. There are a lot of low prices advertised for Caribbean cruises and all-inclusive vacations that may seem like a great bargain, but sometimes what they aren't showing you are the extra costs.
Updated: 12/16/2008 - Officers arrested an area lawmaker for allegedly having marijuana and operating under the influence; Jeff Wood has a previous drunk driving conviction
Updated: 12/14/2008 - In tough times, many people turn to places of faith. But, one place of faith and worship in Eau Claire is having a tough time of their own. The Walk in the Light church may have to move, but the community says they need it to stay.
Updated: 12/14/2008 - Eau Claire North junior and University of Wisconsin basketball recruit Evan Anderson suffered a third-degree right ankle sprain and also tore ligaments that will sideline him for four to six weeks.
Updated: 12/13/2008 - Though economic times are tough, animal lovers say pets need our help. Thanks to some generous donations, homeless pets at the Eau Claire Humane Society will be getting special Christmas treats and toys.


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Aquarium Adventures
11 a.m. Fri, Mar 1 - Fri, May 31, 2013
Venue: Berkshire Musuem
39 South Street, Pittsfield, MA 01201Contact:
Lesley Ann Beck
0 people saved this
Fridays in March, April and May Redesigned with you and your child in mind. Spend quality time getting to know our aquarium friends with playtime, scavenger hunts, animal meet and greets, songs, stories and more. Geared towards children 18 months to 3 years. Older and younger siblings are always welcome!
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YIELD: Makes about 16 cups
With a mandoline or knife cut the potatoes into 1/16-inch slices and pat them dry with paper towels. In a deep fryer heat enough shortening to measure 2 inches to 380°F. and in it fry the potato slices in batches, turning them, until they are golden brown. Transfer the chips with a slotted spoon to paper towels to drain and sprinkle them with the salt.


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Recap: Star Trek Deep Space Nine S 06 E 05 Favor The Bold
After months of enduring heavy losses against the Dominion/Cardassian forces, Sisko presents a plan to take the offensive in the war. He convinces Starfleet Command to commit to 'Operation Return:' the recapture of Deep Space Nine. Unfortunately, Damar figures out a way to deactivate the minefield at the mouth of the wormhole within a week; forcing Starfleet to send its fleet before it's ready, without Klingon support.On the station, an incarcerated Rom and an indifferent Odo means that La Résistance has very little chance of preventing Damar from taking down the mines before Starfleet arrives.
This episode provides examples of:
- Batman Gambit: The Defiant crew fake damage to the ship in order to lure some Jem'Hadar ships into an ambush.
- Berserk Button: Do NOT manhandle Tora Ziyal in front of Major Kira.
- Big Brother Instinct: As Rom becomes resigned to his fate:Quark: Besides, do you think your big brother would let anything happen to you?
Rom: What can you do?
Quark: I'm not sure, but I will think of something. No matter what it takes, no matter what I have to do, I'm going to get you out of here.
- Chekhov's Gun: Morn visiting his mother.
- Character Development: This episode has Sisko declaring his love for Bajor, along with his intention to build a house there once the war is over. Quite a long way from the man who was treating the posting at Deep Space 9 as just another assignment.
- Darkest Hour: The Federation learns the minefield will soon come down, allowing a massive Dominion fleet to come through the wormhole. Lacking the time for additional Starfleet ships or Klingon support to arrive, Sisko has no choice but to take a limited fleet into battle.
- Field Promotion: Nog goes from Cadet to Ensign after spending months on the front lines. O'Brien jokes (though not really) he didn't know the war was going that badly.
- Genre Savvy/Foreshadowing: Damar tells Ziyal that her father knows the alliance with the Dominion is a dangerous one, and if Cardassia shows any weakness, they will become the Dominion's scapegoats. This is what eventually happens in Season 7.
- "Hell Yes" Moment: When Jadzia says they need a big victory to turn the war around, Sisko tells her he intends to propose a major plan to the brass."We're going to retake Deep Space 9."
- Hidden in Plain Sight: The Federation receives word that the minefield around the wormhole is coming down from Morn - Kira's Resistance cell had it encoded on the ribbon he used to wrap his mother's birthday present.
- I Like Those Odds: Averted. Everyone is shocked when they run into a Dominion fleet that outnumbers them two to one. But Sisko knows they have to try and push through anyway. Cue Title Drop.
- No-Holds-Barred Beatdown: See: Berserk Button.
- Oh, Crap: Damar's reaction upon learning that the Federation fleet is heading for the station. Of course, Dukat is more immediately concerned with what happened with Ziyal.
- Rejected Apology: Odo trying to apologize to Kira for what happened last episode:Kira: We are way, way past "Sorry."
- Teeth-Clenched Teamwork: The Bajoran deputy is more than a little uneasy at having to stand guard with a Jem'Hadar.
- Title Drop: "There's an old saying: Fortune favors the bold. Well, I guess we're about to find out."
- You Are a Credit to Your Race: Said to Quark.


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Reston, Va. (December 28, 2011) In a new review of imaging studies spanning more than ten years, scientists find that a method of positron emission tomography (PET) safely and accurately detects dementia, including the most common and devastating form among the elderly, Alzheimer's disease. This research is featured in the January issue of the Journal of Nuclear Medicine.
Researchers reviewed numerous PET studies to evaluate a molecular imaging technique that combines PET, which provides functional images of biological processes, with an injected biomarker called 18F-FDG to pinpoint key areas of metabolic decline in the brain indicating dementia. Having physiological evidence of neurodegenerative disease by imaging patients with PET could give clinicians the information they need to make more accurate diagnoses earlier than ever before.
"The new data support the role of 18F-FDG PET as an effective addition to other diagnostic methods used to assess patients with symptoms of dementia," says Nicolaas Bohnen, MD, PhD, lead author of the study and professor of radiology and neurology at the University of Michigan, Ann Arbor, Mich. "The review also identified new literature showing the benefit of this imaging technique for not only helping to diagnose dementia but also for improving physician confidence when diagnosing a patient with dementia. This process can be difficult for physicians, especially when evaluating younger patients or those who have subtle signs of disease."
Dementia is not a specific illness but a pattern of symptoms characterized by a loss of cognitive ability. These disorders can be caused by injury or progressive disease affecting areas of the brain that control attention, memory, language and mobility. While Alzheimer's is most commonly associated with progressive memory impairment, dementia with Lewy bodies, another form of the disease, can be associated with symptoms of Parkinson's and prominent halluci
|Contact: Rebecca Maxey
Society of Nuclear Medicine


text:
Stock Vector Illustration:
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Most Recent Articles In Print
Latest Print Articles
- InStyle Hires Danielle Prescod as Accessories Editor
- Former Town & Country Editor Frank Zachary Dies at 101
- Details Debuts E-Commerce
More Articles By
ROLLING IN THE VOGUE COVERS?: Adele has racked up a string of magazine covers this year, including Cosmopolitan, British Vogue and The Gentlewoman — and now she may land the biggest cover prize around with American Vogue. Designers have been asked by the title to make special cover outfits for the full-figured chart-topper for the all-important March issue, sources said. Adele is not a sample size, wearing a U.K. size 16, or U.S. 14. She was previously profiled in the April 2009 issue of Vogue. Her second album, "21," is this year's biggest-selling record, according to Billboard, and she was nominated last month for six Grammy awards. A spokeswoman for Vogue declined to comment.


text:
Can Google replenish this resource? If so, how are subscriptions billed when over quota? Costs? Anyone else using it for a real life large scale app? (tens or thousands of users/subcriptions?)
Take the 2-minute tour ×
Stack Overflow is a question and answer site for professional and enthusiast programmers. It's 100% free.
New subscriptions will fail when over the subscription quota. Other quota is still in play but this is a hard ceiling right now.
So, at the time of this writing, unless you plan to keep your number of subscriptions under 10k, you are hosed.
Prospective search is great and I can't wait for it to finally come out of experimental status.
Looking at the documentation here:
The life of a typical prospective search application looks something like this:
Based on that, looks like you are only subjected to the quotas limiting Task Queues, which can be found here.


text:
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Flower sees glimpses of bright future
Andy Flower believes England are gradually developing a formula that can end years of malaise in one-day international cricket, as the team director reflects on ICC Champions Trophy elimination.
Although they were knocked out by holders Australia in the semi-final last night, there were enough signs in progressing from Group B to encourage Flower ahead of the five-match one-day series in South Africa next month.
Flower will discuss winter squad selection with England captain Andrew Strauss and the selectors on Tuesday. It will include favourable reports for Kent opener Joe Denly and Middlesex left-hander Eoin Morgan in particular.
"Look, the bottom line is we didn't get through to the final, and it was disappointing to get that close to having a go at it, but I thought there were glimpses of some very positive things," said Flower.
"Certainly as a batting group I like the aggression that was shown and I think – of course you can't play every game the same – that that's the type of game we want to play as a batting side and our batsmen have to get used to that.
"Some of the individuals showed that they could excel in international cricket. I thought Morgan in the middle order a couple of times played match-winning innings and to do that out of four games is pretty special.
"I also liked the look of Denly up at the front. I know he didn't get any outstanding personal results but I thought he showed a bit of class with the bat, he looked like a good strokemaker, and now he has to improve on from getting his nice thirties to getting bigger scores for us."
England have been criticised for a lack of consistency with selection in the past and Flower is aware of how delicate some decisions could prove with the ICC World Cup now just 18 months away.
"It's always a tricky situation because if guys aren't getting good enough results sometimes you would be silly to carry on in the same vein," Flower said.
"If you look at the number of caps that England players get compared to other nations it does seem that we chop and change quite a lot.
"No-one has guaranteed positions but it would be a good idea, I think, to give guys exposure in their positions and give them time to grow into them.
"Strauss and I have had a lot of time out here to discuss things and discuss it with some of the other players and coaches.
"There aren't going to be wholesale changes, we've basically got the best one-day cricketers in England here.
"There might be the odd change but this tournament was hopefully the start of something a little different."
Having arrived in South Africa on the back of a 6-1 hammering by Australia in the NatWest Series, the victories over Sri Lanka and the host nation have increased optimism, particularly given that Kevin Pietersen is scheduled to return from his Achilles injury when England return here in November.
"We can't say yet but I am still thinking positively along the lines of him starting the South African tour," Flower confirmed.
"I am very hopeful that we can play good one-day international cricket out here.
"It is going to be a tough series - that South African side is a very good side - and it is also going to be important in the context of the Test tour."
After showing they have the talent to beat some of the world's best sides, the customary poor start against the Australians was made all the more disappointing.
"I must say once getting into the semi I felt that we had a very good chance of getting through," said Flower. "Australia played out of their skins - I wouldn't say we didn't compete but we weren't in the same ball park yesterday.
"But there were good things to come out of this tournament – the wins against South Africa and Sri Lanka were superb wins in high-pressure environments."


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Watch One Direction Work Out, Dirty Dance + Rap [VIDEOS]
Warning: These videos contain lots of shirtless, sweaty scenes of One Direction working out and getting in shape, as well as dirty dancing.
Warning: These videos contain lots of shirtless, sweaty scenes of One Direction working out and getting in shape, as well as dirty dancing.
One Direction won Favorite Pop/Rock Album at the 2013 American Music Awards (Nov. 24). It was their first AMA win ever!
The internet hath no fury like One Direction scorned. When Alicia Silverstone mistakenly called 1D "New Direction" on the red carpet at the 2013 American Music Awards (which was seen live on air on E!), Directioners were not pleased. The fans took to Twitter to voice their anger over the mistake.
The 2013 American Music Awards were rife with amazing performances from Katy Perry, Ariana Grande, One Direction, Rihanna, Miley Cyrus, Justin Timberlake, Christina Aguilera, Pitbull featuring Kesha and more. And you can catch them all here!
One Direction closed out their big 1D Day yesterday (Nov. 23) with a special guest -- Michael Buble!
One Direction are a billion dollar business with a new album out next week, so they are the current Billboard cover stars.
Former "Saturday Night Live" castmember Jimmy Fallon will make his return to the late-night comedy show in December, and he'll be joined by none other than his "History of Rap" and "Barry Gibb Talk Show" partner Justin Timberlake.
One Direction performed their new single 'Story of My Life' on 'X Factor' tonight (Nov. 21) and probably gave the show its best ratings of the season. It was, in a word, flawless.
Haylor are a looooooooong dead thing of the past, but almost a year after their split, we're still interested in anything involving Taylor Swift and One Direction's hunky Harry Styles.
Don't ask us which of the individual and super swoon-worthy One Direction covers for the December 2013/January 2014 issue of Seventeen is our favorite. We love them all!
One Direction revealed quite a bit about themselves on 'The Jonathan Ross Show' -- and about their love lives. Why does Niall Horan get so many girls? How does Harry Styles really feel about Taylor Swift and Cara Delevingne? What is Styles' bizarre physical abnormality? And Liam Payne gets even more personal ... and a little gross!
One Direction won two awards at the BBC Radio 1 Teen Awards. They couldn't be there to celebrate, so they accepted remotely by filming two hilarious videos.


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Backup Exec Upgradation from BE 2010 to BE 2012
I know DLO is a separate product now and the new version of DLO is 7.5. What will happen to the DLO that is present in BE 2010 when BE 2010 is upgraded to BE 2012? Please let me know.
Comments 2 Comments • Jump to latest comment
...it will probably be uninstalled seeing as how BE 2010's version of DLO was installed with the base software (activating a license key!).
Best bet to upgrade to DLO 7.5 first, then upgrade to BE 2012...
Alternative ways to access Backup Exec Technical Support:
Hello Shamee,
If DLO 2010 is still present on the server then it will not allow you to upgrade to BE 2012. You will either have to upgrade DLO to DLO 7.0 or higher or uninstall DLO option completely before upgrading to BE 2012.
Please refer to the following technotes
http://www.symantec.com/docs/TECH186023 : How to upgrade DLO when Backup Exec is being upgraded to Backup Exec 2012
http://www.symantec.com/docs/TECH180330 : Backup Exec 2012 upgrade reports the Backup Exec Desktop and Laptop Option feature has been detected and must be migrated or uninstalled before the installation can continue.
Hope this piece of Information Helps you... and if it does then mark this response as Solution....!!!


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You gotta 'Believe' in this YouTube hit
You gotta 'Believe' in this YouTube hit
Lynnfield musician/filmmaker John Michael Williams recorded a haunting song about love and faith and put it up on YouTube last month. He sent it out to family and friends, whereupon, he said, "It went out and made babies."
Less than a month later, "I Believe in You" has more than 41 million hits, it is the No. 1 video in 14 countries and has received three times as many views as Justin Bieber's "All Around The World," which went up the same day.
|The article you requested has been archived


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The San Antonio College GED-to-College transition program is currently accepting applications for the Fall 2015 semester. The award-winning GED-to-College program is tailored for individuals who want to enroll at SAC after earning their GED. Read More >
San Antonio College was recently named one of the nation's top producers of Latino graduates in the Science, Technology, Engineering and Math (STEM) fields. Read More >
President of San Antonio College, Dr. Robert Vela, earns "2015 Javelina Distinguished Alumnus" award. Read More >
San Antonio College celebrated Memorial Day with a special luncheon ceremony on Monday afternoon at the Loftin Student Center. Read More >
The Tino & Millie Duran Welcome Center gives San Antonio College a new "front door" on North Main Avenue.
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San Antonio College hosted its annual Commencement Ceremony at the Freeman Coliseum on Saturday where a record 1,009 students crossed the stage to ceremonially receive a diploma, certificate or associate degree. Read More >
On Friday, May 1, the Office of Academic Success hosted a faculty 'charrette' with some 120 members of the faculty, student services personnel, and administrators.
Read More >
Dr. Helen Vera, Director of the Department of Services for Women & Non-Traditional Students (SWANS), and her staff have been recognized by the National Academic Advising Association (NACADA) with an Outstanding Advising Program Award. Read More >
The William R. Sinkin Eco Centro at San Antonio College has been awarded a $200 mini-grant from the Native Plant Society of Texas (NPSOT). Read More >
The Early Childhood Center at San Antonio College has child care openings for the Summer 2015 and Fall 2015 semesters and is currently accepting applications. Read More >
The Scobee Education Center at San Antonio College will take teachers on a real-life space adventure with a pair of professional development workshops this summer. Read More >
The San Antonio College Interpreter Training Program has been named a Sorenson Video Relay Service (SVRS) Excellence and Innovation in Interpreter Education Award. Read More >
Kathryn Ramirez, an education major, is the winner of the annual president's holiday card design contest. She received a $500 scholarship on Dec. 7 at President Zeigler's annual holiday brunch for staff and faculty held in the Koehler House.
Kathryn's winning entry was a hand drawn trio of snowmen. It was among 12 entries this year. The card serves as the invitation to the holiday brunch.
Pictured: Kathryn Ramirez, accepts her scholarship with her parents, Robert and Annette Ramirez and San Antonio College President Dr. Robert Zeigler.
Photo by Leonard Ziegler
Photo by Leonard Ziegler
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