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Congress votes to open up ski areas on federal land for more uses, including eight in Washington
WASHINGTON — If you've ever dreamed of a summer wedding at a ski area on federal lands, then today is your lucky day.
Following the lead of the House, the Senate voted late Tuesday night to approve the Ski Area Recreational Opportunity Enhancement Act, which will allow ski areas in national forests to be used for much more than skiing.
According to U.S. Sen. Maria Cantwell, D- Washington, one of the bill's cosponsors, new activities could include mountain biking, "expanded scenic opportunities," summit hiking, and "expanded hospitality opportunities" such as restaurants and summer weddings.
She said eight ski areas in …


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Trinidad and Tobago : Exercise a high degree of caution
Last Updated: June 10, 2015 16:31 EST1. RECENT UPDATESA minor editorial change was made.2. ADVISORIESTRINIDAD AND TOBAGO - Exercise a high degree of cautionThere is no nationwide advisory in effect for Trinidad and Tobago. However, you should exercise a high degree of caution due to a high crime rate.3. SECURITYThe decision to travel is your responsibility. You are also responsible for your personal safety abroad. The purpose of this Travel Advice is to provide up-to-date information to enable you to make well-informed decisions.CrimeViolent robberies, assaults and rape occur frequently. Cruise ship passengers should take particular care when walking around the docks in Port of Spain. Gang and drug-related violence, including shootings and kidnappings, occurs and can affect bystanders. Crimes of opportunity such as petty theft tend to increase during the annual Trinidad Carnival in February or March and during the Christmas holidays.Remain highly vigilant in Laventille and at popular tourist sites such as Fort George, La Brea (Pitch Lake) and Las Cuevas beach, where crimes targeting foreigners have been reported. Incidents of gangs following cars leaving Trinidad's Piarco International Airport and robbing travellers once they reach their destination have been reported. Avoid unpopulated areas such as scenic overlooks, especially after dark.Avoid visiting isolated and unpatrolled beaches due to the risk of crime. On certain beaches, security is provided from 8 a.m. to 6 p.m. only.Tourists and foreign nationals are also victims of crime in Tobago. Maintain a high level of vigilance and personal security awareness at all times. Avoid visiting isolated and unpatrolled beaches due to the risk of crime, even in daylight. 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subset: commoncrawl


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Physiologic doses of urocanic acid do not alter the allostimulatory function or the development of murine dendritic cells in vitro
Article first published online: 6 SEP 2011
DOI: 10.1111/j.1600-0781.1997.tb00222.x
1997 Blackwell Munksgaard
Photodermatology, Photoimmunology & Photomedicine
Volume 13, Issue 5-6, pages 163–168, October-December 1997
Additional Information
How to Cite
Lappin, M. B., Weiss, J. M., Schöpf, E., Nerval, M. and Simon, J. C. (1997), Physiologic doses of urocanic acid do not alter the allostimulatory function or the development of murine dendritic cells in vitro. Photodermatology, Photoimmunology & Photomedicine, 13: 163–168. doi: 10.1111/j.1600-0781.1997.tb00222.x
Publication History
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted for publication September 11, 1997
- Abstract
- References
- Cited By
- urocanic acid;
- dendritic cell
Exposure to UVB results in the isomerization of trans-urocanic acid (UCA), localized in the stratum corneum, to cis-UCA. Cis-UCA can mediate at least some of the immunosuppressive effects of UVB, though the mechanism of cis-UCA action remains incompletely defined. Alterations in Langerhans cells, and other dendritic antigen presenting cell populations in the skin, may contribute to the loss of skin immune function following UVB exposure. Hence, this study was designed to investigate whether cis-UCA directly can induce changes in the immunostimulatory capacity of dendritic cells (DC) and the development of DC from precursor cells. Murine DC were generated from C57BL/6 bone marrow (BM) using granulocyte-macrophage colony-stimulating factor (GM-CSF), and were used as stimulator cells in mixed lymphocyte reactions (MLR) using BALB/c lymph node cells (LNC) as responders. The addition of cis- and trans-UCA at concentrations ranging from 0.1–500 μg/ml to the MLR did not affect proliferative responses. Cis- or trans-UCA (100 μg/ml) was added to GM-CSF stimulated mouse BM cells on day 0, day 3 or day 5 of culture, and the phenotype and allo-stimulatory function of the DC were analysed on day 7. Treatment with cis- or trans-UCA did not affect the numbers or the viability of cells in the BM cultures. In addition, the expression on DC of Iab, CD11c or the costimulatory molecules ICAM-1, B7-1, B7-2 and CD40 was not altered by the addition of cis-UCA to BM cultures. The inability of cis-UCA to alter the development of DC in vitro was confirmed by analysing the functional capacity of DC in MLR. DC generated in the presence of cis-UCA were equally efficient in the induction of allo-stimulation, when compared with control DC. These results suggest that cis-UCA does not exert its immunosuppressive activity through direct effects on DC. Such activity may be independent of DC, or alternatively, cis-UCA may influence DC function indirectly, through the induction of secondary mediators.


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I'm not surprised that the minimum wage will eventually be raised to $15 per hour in Seattle. The cost of living and housing is very high in that prosperous city. Some conservatives worry that businesses cannot afford to hire workers at $15 per hour so jobs would be lost. That's probably true in more depressed areas like rural Kansas where there is less prosperity and things are cheaper. When President Obama talks about raising the minimum wage, he is not talking about $15 per hour. Proposals to raise the national minimum wage are a lot more modest. There is a big difference between various areas of this country when it comes to cash flow, prosperity and the cost of things like housing. It's almost like comparing apples and oranges. To a large extent the politics of wages and prices is local due to wide gaps between circumstances in different parts of the country. The cost of housing is one thing that can make a really big difference.
Robert Ashworth


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Oil, Gas and Consumable Fuels
Company Overview of Rice Energy Inc.
Company Overview
400 Woodcliff Drive
Canonsburg, PA 15317
United States
Founded in 2008
308 Employees
Key Executives for Rice Energy Inc.
Rice Energy Inc. Key Developments
Rice Energy Inc. announced unaudited consolidated earnings and operating results for the first quarter ended March 31, 2015. For the quarter, the company reported total operating revenues were $109,539,000 compared to $90,477,000 a year ago. Operating loss was $31,080,000 compared to $33,795,000 a year ago. Income before income taxes was $13,217,000 compared to $138,829,000 a year ago. Net income was $4,687,000 compared to $129,454,000 a year ago. Net income attributable to Rice Energy Inc. was $152,000 or nil per diluted share compared to $129,454,000 or $1.03 per diluted per share a year ago. Adjusted net loss was $3,094,000 or $0.02 per diluted per share compared to adjusted net income of $62,611,000 or $0.50 per diluted per share a year ago. Adjusted EBITDAX was $84,276,000 compared to $64,803,000 a year ago. Net debt was $964,867,000 as on March 31, 2015. During the first quarter 2015, daily net production averaged 440 MMcfe/d, an 11% increase over fourth quarter 2014 volumes and 111% increase over pro forma first quarter 2014 production. Total production was 39,621 MMcfe. The company increasing 2015 annual production guidance to 470 - 490 MMcfe/d, due to accelerated well timing from increased operational efficiencies. The company reaffirming 2015 capital budget of $890 million including E&P and retained midstream investments. For the second quarter, The company expects to bring online 17 net wells and production to average 470 million to 475 million cubic feet per day, which is a 7% to 8% increase above first quarter 2015 average.
On April 30, 2015, Rice Energy Inc. entered into the Fourth Amendment to its Third Amended and Restated Credit Agreement, among the company, Wells Fargo Bank, N.A., as administrative agent, and the lenders and other parties thereto (the Amended Credit Agreement). The lenders under the Amended Credit Agreement completed their semi-annual redetermination of the borrowing base scheduled for on or about May 1, 2015 (which was originally scheduled for on or about April 1, 2015 but postponed as a result of the company's March 2015 senior notes issuance). Following the redetermination, the company's borrowing base increased from $550 million to $650 million. Additionally, the company added three new lenders to the bank group. The next redetermination of the borrowing base is scheduled for October 2015.
Rice Energy Inc. Presents at Hart Energy Publishing LP 6th Annual DUG East Conference, Jun-24-2015 04:15 PM. Venue: David L. Lawrence Convention Center, 1000 Fort Duguesne Blvd, Pittsburgh, PA 15222, United States. Speakers: Derek A. Rice, Executive Vice President of Exploration.
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To contact Rice Energy Inc., please visit www.riceenergy.com. Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at email@example.com.


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The new A3 aPen is the hottest new gadget for back to school. aPen is a digital pen that lets you digitize and record handwritten notes or photo skteches via wireless sync to your PC, Blackberry or Android phone using Bluetooth technology.
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Natural Immunity Journal Impact Factor & Information
Journal description
Covers current research relating to all aspects of tumor biology. Discontinued in 1998.
Current impact factor: 0.00
Impact Factor Rankings
|2015 Impact Factor
|Available summer 2015
|2000 Impact Factor
|1999 Impact Factor
|1998 Impact Factor
|1997 Impact Factor
Impact factor over time
Additional details
|5-year impact
|Cited half-life
|Immediacy index
|Article influence
|Natural Immunity website
|Material type
|Periodical, Internet resource
|Document type
|Journal / Magazine / Newspaper, Internet Resource
Publisher details
- Pre-print
- Author can archive a pre-print version
- Post-print
- Author can archive a post-print version
- Conditions
- On author's server or institutional server
- Server must be non-commercial
- Publisher's version/PDF cannot be used
- Publisher copyright and source must be acknowledged
- Must link to publisher version
- Classification green
Publications in this journal
Article: Andrei Sulica, MD, 1938-2000.[Show abstract] [Hide abstract]
ABSTRACT: Copyright 2000 S. Karger AG, BaselNatural Immunity 10/1998; 16(5-6):176-177.
Article: Influence of an interferon inducer on bone marrow transplant reconstitution in irradiated, leukemic mice: elevated natural killer cell numbers and improved life span.[Show abstract] [Hide abstract]
ABSTRACT: Interferon-gamma and interferon inducers such as polyinosinic-polycytidylic acid (poly I:C) promote natural-killer (NK)-cell-mediated killing of a wide range of tumor cells both in vitro and in vivo. The aim of the present work was to administer poly I:C to irradiated, leukemic mice, both before and after syngeneic bone marrow transplant with the intent of boosting the host's natural immunity in the critical peritransplant period. Briefly, DBA/2 mice were injected with Friend-virus-induced erythroleukemia cells. After 5 days of tumor growth, some mice received daily injections of poly I:C for the next 4 days while control, leukemic mice received the saline vehicle only. All mice were then irradiated (450 R x 2 at 4-hour intervals) and transplanted 1 day following irradiation with bone marrow from age- and sex-matched, normal DBA/2 donor mice. After transplant, daily injections of poly I:C (or vehicle) continued for 8 more days. On day 9 after transplant, treated and control mice were killed, and the total cellularity, total numbers of lymphoid cells, the total numbers of NK cells (identified by the presence of an immuno-labelled, specific cell surface marker) were obtained from both the spleen and the bone marrow. Other identically treated mice subjected, however, to several additional rounds of poly I:C treatment were sampled 3 and 6 months after irradiation and bone marrow transplant. The results indicated that (a) poly I:C administered in the peritransplant period (before and after transplant) significantly increases the absolute numbers of NK cells in both the bone marrow and spleen of the transplanted host at all time intervals studied, (b) no erythroleukemic tumor cells were found, even as late as 6 months after transplant in the poly-I:C-treated hosts in spite of the fact that poly I:C treatment in this group had been terminated more than 2 months prior to tissue sampling, and (c) survival was significantly improved by pre- and posttransplant treatment with poly I:C.Natural Immunity 02/1998; 16(1):6-17. DOI:10.1159/000069425
Article: Natural killer cell levels in older adult mice are gender-dependent: thyroxin is a gender-independent natural killer cell stimulant.[Show abstract] [Hide abstract]
ABSTRACT: The present study aimed to quantitatively analyze the effects of thyroxin on natural killer (NK) cells in the bone marrow and spleen of older adult (6 months) mice of both sexes. Five intraperitoneal injections of thyroxin were administered over 10 days in an attempt to stimulate the virtually negligible levels of NK cells in these older mice. Immunoperoxidase labeling of an NK cell surface marker, together with a tetrachrome hematologic counterstain, permitted morphological microscopic identification of mature NK cells, distinct from all other hemopoietic and immune (lymphoid) cells in the spleen and bone marrow. The results revealed that in spite of similar total cell content in both the spleen and bone marrow in both sexes at this age, there were significant, gender-based differences in NK cells and various other hemopoietic and immune cells. NK cells in the 6-month-old female mice are significantly more abundant than those of males at this age. Granulocytes in females were also significantly more numerous in both the spleen and bone marrow than in males. By contrast, monocytes and nucleated erythroid cells were significantly more numerous in males of this age. In both sexes, at this postbreeding age, the immunostimulant, thyroxin, had the common effect of significantly elevating the levels of NK cells. Our results underline the need for considering the two basic parameters of age and gender, as potentially confounding variables, prior to therapeutic administration of thyroxin, and possibly a host of hormones, cytokines and other regulators of hemopoietic and immune phenomena.Natural Immunity 02/1998; 16(4):165-74. DOI:10.1159/000069441
Article: No evidence of IFN-gamma increase in the serum of HIV-positive and healthy subjects after subcutaneous injection of a non-fermented viscum album L. extract.[Show abstract] [Hide abstract]
ABSTRACT: Iscador, an aqueous extract of Viscum album L., has been used for more than 80 years as an anticancer drug. Due to its immunomodulatory potential, since the onset of the AIDS epidemic it has also been applied in the treatment of HIV-positive and AIDS patients in the form of the preparation V. album QuFrF (VaQuFrF; Labor Hiscia, Arlesheim, Switzerland). In in vitro investigations, incubation of peripheral blood mononuclear cells with V. album L. extracts resulted in stimulation of lymphocyte activity with increased gene expression and release of various cytokines and also of interferon gamma (IFN-gamma). In the latent phase, HIV positives exhibit only slightly elevated IFN-gamma concentrations in serum in comparison with HIV negatives, but in the acute phase of AIDS, there is an increase in levels of IFN-gamma. As the assay of cytokine levels in serum is a simple method of measuring immune system reactions, the aim of this trial was to determine whether increases in serum IFN-gamma levels in HIV positives and HIV negatives can be detected using this method after repeated injections of VaQuFrF. Five healthy subjects and 13 HIV-positive patients were investigated. IFN-gamma concentrations in serum were assayed using an ELISA test kit (ELISA test; ENDOGEN, Cambridge, Mass., USA). No drug-related elevation of serum IFN-gamma was observed at any time point during the trial. It can thus be concluded that this method is not suitable for direct investigation of the immunomodulatory effects of VaQuFrF in vivo.Natural Immunity 02/1998; 16(4):157-64. DOI:10.1159/000069440
Article: Impaired T lymphocyte function and differential cytokine response pattern in members from cancer families.[Show abstract] [Hide abstract]
ABSTRACT: In an attempt to understand the basis of lowered natural killer (NK) and T cell functions in unaffected members from cancer families, we investigated cytotoxic T lymphocyte function (CD3-directed lysis) and the ability of the lymphocytes to respond to cytokines such as IL-2, IFN-alpha and IL-12. We observed lower CD3-mediated cytotoxic activity in these individuals supported by significantly lower numbers of circulating CD3+ lymphocytes. The cytokine treatment studies revealed impaired response to IFN-alpha and IL-12 in unaffected members and breast cancer patients. The observations presented herein not only reinforce our earlier finding that lower NK and T lymphocyte function may be a feature of cancer families, but also suggest that such impaired responses may be one of the factors contributing to lower cytotoxic potential of the circulating lymphocytes.Natural Immunity 02/1998; 16(4):146-56. DOI:10.1159/000069439
Article: Immunomodulatory effects of IL-12 in relation to the pineal endocrine function in metastatic cancer patients[Show abstract] [Hide abstract]
ABSTRACT: In addition to IL-2, IL-12 would constitute one of the most promising cytokines in the treatment of human neoplasms. IL-2 has been proven to induce in vitro and in vivo several evident changes in the secretion of cytokines and various other immunoinflammatory substances. In contrast, very little data are available about the immune effects of IL-12 in humans. The present study was carried out to investigate the in vivo immunoinflammatory effects of IL-12 by analyzing the secretions of neopterin, soluble IL-2 receptor (SIL-2R), tumor necrosis factor alpha (TNF), IL-2 and IL-6 in relation to the neuroendocrine function of the pineal gland, which is one of the most important organs involved in neuroimmunomodulation. Pineal endocrine function was investigated by evaluating the whole daily urinary excretion of the main catabolite of its hormone melatonin, 6-sulfatoxymelatonin (6-MTS). The study was performed on metastatic renal cell cancer patients. Each course of IL-12 consisted of 1.25 microg/ kg b.w. subcutaneously in the morning once a week for 3 consecutive weeks. The study evaluated 10 IL-12 courses. Mean serum levels of neopterin, SIL-2R and TNF significantly increased in response to IL-12, whereas no significant change occurred in IL-6 and IL-2 mean concentrations. Finally, 6-MTS urinary excretion was significantly reduced by IL-12 injection, particularly during the dark phase of the day. This preliminary study would suggest that IL-12 may induce important changes in the in vivo immunoinflammatory response. Moreover, IL-12 administration would suppress pineal endocrine activity, thus confirming its previously suggested involvement in the neuroimmunomodulatory processes. Because of the fundamental role of the pineal gland in neuroimmunomodulation, IL-12-induced immune variations could depend at least in part on its action at central neuroendocrine sites.Natural Immunity 02/1998; 16(5-6):178-84. DOI:10.1159/000069444
Article: Decrease of activated lymphocytes four and nine hours after a subcutaneous injection of a Viscum album L. extract in healthy volunteers.[Show abstract] [Hide abstract]
ABSTRACT: The immunomodulatory substance, VaQuFrF (an aqueous extract of Viscum album L. of the oak tree) is used as an adjuvant and as monotherapy in the treatment of cancer and AIDS. After subcutaneous injection, there is a local inflammatory reaction at the injection site and systemic elevation of activated lymphocytes. The immunomodulatory effect of VaQuFrF in the first 24 h after subcutaneous injection on blood leukocyte and lymphocyte subpopulation was investigated. Because a significant natural circadian variation of these cellular parameters exist, the influence was studied in regard to this. In two groups of healthy volunteers, one group receiving VaQuFrF, the following parameters were measured every 2-3 h over a period of 24 h: leukocytes, band form, segmented and eosinophilic granulocytes, monocytes, total lymphocytes and CD4-, CD8-, CD3/25- and CD8/38-positive lymphocytes in count and percentage. In regard to the natural circadian variation 24 h after injection of VaQuFrF, a statistically significant fall in the absolute numbers and percentage of CD3/ 25- and CD8/38-positive lymphocytes was observed. Also, monocytes in percent and absolute numbers show a transient fall 6-9 h, lymphocytes only in absolute and CD4-positive lymphocytes only in percentage 2 h after injection. The results demonstrate that there is increased extravasation of (activated) lymphocytes and monocytes after subcutaneous injection of 1 mg VaQuFrF.Natural Immunity 02/1998; 16(5-6):185-97. DOI:10.1159/000069445
Article: Expression of Fas and Fas ligand and apoptosis in tumor-associated lymphocytes and in tumor cells from malignant pleural effusions.[Show abstract] [Hide abstract]
ABSTRACT: The CD95 (APO-1/Fas)-Fas ligand (FasL) system is an important mediator of antitumor T cell cytotoxicity. The aim of the current study was to assess its significance in human cancer. Malignant effusions were selected as an environment allowing direct cell-to-cell contact in a fluid phase. Malignant pleural effusions collected from 23 patients with metastatic carcinoma of the bronchus, ovary, stomach or breast were examined by means of flow cytometry. The expression ofFas and FasL, probed with the appropriate antibodies, apoptosis of tumor cells and the characteristics of tumor-associated lymphocytes (TAL) were determined by TUNEL reaction in malignant and nonmalignant (control) effusions. All malignant cells had partially or completely lost the expression of CD95 and expressed an elevated level of FasL. In contrast, TAL obtained from malignant pleural effusions demonstrated a marked decrease in the expression of surface FasL and an increase in surface-bound Fas. The percentage of apoptotic malignant cells was significantly decreased, as compared to TAL and lymphocytes from nonmalignant pleural effusions. There were also differences in the expression of Fas and FasL among mononuclear cells from malignant and nonmalignant pleural effusions. The ability of TAL from malignant pleural effusions to induce apoptosis of K562 cells was diminished, as compared to peripheral blood lymphocytes. Taken together, these data suggest that tumor cells in the microenvironment of malignant pleural effusions can evade immune attack by downregulation of the CD95 receptor and by killing lymphocytes through the expression of FasL. These results confirm earlier reports which showed that lymphocytes from a tumor microenvironment appear to have a depressed cytotoxic action.Natural Immunity 02/1998; 16(5-6):244-55. DOI:10.1159/000069450
- [Show abstract] [Hide abstract]
ABSTRACT: The present investigation was carried out to study the effect of tumor growth on the spleen of an aged host. Dalton's lymphoma (DL), a spontaneous T cell lymphoma, was grown in mice of different age groups classified as young, adult or old on the basis of their reproductive status. Splenocytes obtained from normal and tumor-bearing young, adult and old mice were checked for an in vitro blastogenic response to concanavalin A (Con A), colony-forming ability and apoptosis. There was an enhanced apoptosis of splenocytes and a concomitant inhibition of splenocyte blastogenesis and their responsiveness to the mitogenic stimulus of Con A in aged mice. The counts of granulocyte macrophage- and macrophage-colony forming units were significantly enhanced in the spleen of tumor-bearing adult mice. It is proposed that the DL-growth-dependent increase in the size of the spleen in adult mice is due to an increased blastogenesis of splenocytes, which, however, may not be applicable in the case of old tumor-bearing mice. The role of splenic macrophages in the regulation of the functions of the spleen by macrophage-derived NO is shown.Natural Immunity 02/1998; 16(5-6):215-27. DOI:10.1159/000069448
Article: Effect of a recombinant lectin, Viscum album agglutinin on the secretion of interleukin-12 in cultured human peripheral blood mononuclear cells and on NK-cell-mediated cytotoxicity of rat splenocytes in vitro and in vivo.[Show abstract] [Hide abstract]
ABSTRACT: A plant lectin, Viscum album agglutinin-I (VAA-I) has been shown to increase the number and cytotoxic activity of natural killer (NK) cells in animal models, but the mechanisms underlying these effects are poorly understood. We investigated the effects of the recombinant form of this lectin (rVAA) on secretion of interleukin (IL)-12 and on NK-mediated cytotoxicity against K562 target cells in cultures of human peripheral blood mononuclear cells (PBMC) as well as against YAC-1 target cells in cultured rat spleen cells. In 24-hour cultures of PBMC, 10 ng/ml plant VAA-I and 50 ng/ml rVAA induced significant increases in the secretion of total IL-12. Its biologically active heterodimeric form, p70, was also significantly induced by rVAA. Preincubation of PBMC or splenocytes for 48 h with rVAA in concentrations ranging between 10 pg/ml and 100 pg/ml resulted in moderate enhancements of NK-mediated cytotoxicity. However, coincubation of a low dose of rVAA (100 pg/ml) together with IL-2 and IL-12 (60 U/ml and 2 U/ml, respectively) led to additive stimulation of NK activity. In in vivo experiments, rVAA showed an enhancing effect on NK activity with a bell-shaped curve of efficacy. Forty-eight hours after a single intravenous injection of its most effective doses, 0.5 and 1 ng/kg, into Wistar rats, the NK cytotoxicity of splenocytes against YAC-1 targets doubled, and the frequency of large granular lymphocytes in peripheral blood showed 2.1- and 3-fold increases as compared to control animals. Twenty-four hours following these low lectin doses, the number of large granular lymphocytes was also significantly elevated. After 48 h, 0.5 ng/kg rVAA induced a significant augmentation in the percentage of peripheral Mac-1+ mononuclear cells, including activated monocytes and NK cells. The present results suggest that rVAA augments the secretion of an active form of IL-12 and potentiates the cytokine-induced NK activation. These effects of rVAA may be related to its stimulatory effects on MHC-unrestricted cytotoxicity in vivo.Natural Immunity 02/1998; 16(1):34-46. DOI:10.1159/000069428
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ABSTRACT: The role of Ikaros in early stages of natural killer (NK) cell differentiation was investigated using an in vitro system that promotes proliferation and differentiation of NK cell precursors into mature NK1.1+ cells. Day 14.5 fetal liver cells from mice, either homozygous for Ikaros Null or dominant negative (DN) mutations, had severe 55- to 79-fold reductions in functional NK cell precursors. Although there was no statistically significant difference between values for +/+ and +/- Null mice, the mean precursor frequency for DN mutant (+/-) mice was significantly above that for DN -/- mice and below that for DN +/+ mice. The NK activity values for cells generated from the NK cell precursors followed the same respective relationships found for NK cell precursor frequencies. These data suggest that the deficiency of mature NK cells in Ikaros mutant mice is related to lack of functional precursors.Natural Immunity 02/1998; 16(4):137-45. DOI:10.1159/000069438
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ABSTRACT: The CD95/CD95L (Fas/Fas ligand) receptor/ligand system plays an important role in regulation of cell survival and induction of a programmed cell death. It is also involved in regulation of effector phase of T and NK cell cytotoxicity, establishment of immune privilege sites, and tumor escape from immune recognition. In this study, we assessed expression of CD95L in tumors obtained from patients with neuroblastoma (NB) and in established NB cell lines. We measured the presence of intratumoral T cell infiltrates and T cell survival in tumor tissue samples. High levels of apoptosis were observed in tumor-associated lymphocytes as well as in Jurkat T cells cocultured with NB cells in vitro. T cell death was reduced after treatment of NB cells (in vitro) with antibody to FAS ligand (FasL). Overall, our data suggest that NB-induced apoptosis of Fas-sensitive Jurkat T cells is mediated by functional FasL expressed on NB and Fas/FasL interaction may be responsible for the elimination of T cells in the NB microenvironment.Natural Immunity 02/1998; 16(5-6):263-74. DOI:10.1159/000069452
Article: Natural killer cell frequency and function in pigs selectively bred for high or low antibody and cell-mediated immune response: response to vaccination with modified live transmissible gastroenteritis virus.[Show abstract] [Hide abstract]
ABSTRACT: Porcine NK cells are small to medium lymphocytes which are lytic for tumours and virally infected cells when co-cultured for long periods ( approximately 16 h). The frequency and function of NK cells were examined in generation 8 of pigs genetically selected for high (H), low (L), and control (C) antibody (Ab) and cell-mediated immune response (CMIR). The NK phenotype was identified using a pan-species NK-specific murine monoclonal antibody (5C6) and both binding and lysis of the NK target, K562. Vaccination with modified live transmissible gastroenteritis virus (TGEV) had no effect on blood leucocyte NK cell frequency. In interactions with K562 targets, NK cells of H and C pigs responded similarly in frequency of conjugate formation and lytic activity, while L pigs had very little or no response. Therefore, in pigs selected for high Ab and CMIR, there was no correlated enhancement of NK-cell-related traits following vaccination with TGEV, while selection for low immune response was associated with reduced NK response in pigs. This may suggest that low immune response can reflect reduced contribution of NK cells in pigs.Natural Immunity 02/1998; 16(1):18-26. DOI:10.1159/000069426
Article: The concept of an immune mechanism of chemical homeostasis and its importance in biology and medicine.[Show abstract] [Hide abstract]
ABSTRACT: This paper outlines research that has led to the concept of the inevitable participation of the immune system in an organism's chemical homeostasis. This function of the immune system is tentatively named the 'immune mechanism of the chemical homeostasis' (IMCH). It is based on the theory of a permanent physiological synthesis of antibodies to endogenous biologically active substances. Minimal accumulation of biologically active substances as a result of the influence of different factors specifically activates the immune system in order to maintain its chemical homeostasis. The concept suggests the necessity of widening the notion of the range of the immune system's censorial functions. The concept explains the preexistence of immunocompetent cells preadapted to biologically active substances and autoantibodies specific to them; the natural clonality of the B lymphocyte pool; the polyclonal lymphocyte activation triggered by mitogens, foreign proteins, erythrocytes, and microbes, and tolerance to drugs.Natural Immunity 02/1998; 16(5-6):198-206. DOI:10.1159/000069446
Article: CSF-1 (M-CSF) enhances the inflammatory response of fibronectin-primed macrophages: pathways involved in activation of the cytokine network.[Show abstract] [Hide abstract]
ABSTRACT: We have previously reported that the priming of thioglycollate-elicited peritoneal macrophages (PMphi), as a representative population of mononuclear phagocytes (MNP), by macrophage-colony-stimulating factor (M-CSF or CSF-1) rendered these cells more susceptible to secondary stimulation by extracellular matrix (ECM) proteins, in particular fibronectin (FN), and that at least two beta1 integrins, VLA 4 (alpha4beta1 or CD49d) and VLA 5 (alpha5beta1 or CD49e), regulate IL-6 gene expression when PMphi come into contact with FN. In this report, we focused our attention on resident PMphi, as a more mature/differentiated MNP subpopulation. By using granulocyte-macrophage colony-stimulating factor (GM-CSF)- and IL-6-knockout (null) mice, we demonstrated that the cooperative effect between CSF-1 and FN in IL-6 release was a result of a sequential stimulation of the GM-CSF, but not the TNF-alpha, gene via interaction with VLA 5. We also showed that regardless of the presence or absence of CSF-1 or FN, IL-6 inhibits GM-CSF and TNF-alpha gene expression in an autocrine manner. The observed effects were specific because CSF-1 enhanced VLA 5 expression and blocking FN-treated resident PMphi in vitro with VLA 5 monoclonal antibodies inhibited the IL-6 response. We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release. An increased level of VLA 5 expression was observed in PMA-treated resident PMphi. We concluded that in inflammatory processes, CSF-1 drives a number of pathways involved in the regulation of the expression of several genes and renders MNP highly susceptible to stimulation by ECM proteins that transform the MNP into secretory inflammatory cells.Natural Immunity 02/1998; 16(5-6):228-43. DOI:10.1159/000069449
Article: Clinical implications of natural killer cytotoxicity in patients with squamous cell carcinoma of the penis.[Show abstract] [Hide abstract]
ABSTRACT: Impairment of natural cytotoxicity mediated by natural killer (NK) cells may play a role in the pathogenesis of penile carcinoma. The aim of this study was to examine the NK activity profile and its prognostic significance in patients with squamous cell carcinoma of the penis. The NK activity was measured in peripheral blood mononuclear cells (PBMCs) from 39 patients diagnosed histologically as having invasive squamous cell penile carcinoma and 4 patients with verrucous carcinoma of the penis. Of 39 patients with invasive squamous cell carcinoma, 4 had undergone previous penile amputation. According to the prognosis, the patients with invasive squamous cell carcinoma were divided into two groups: with metastasis and without metastasis. The patients were evaluated in relation to clinicopathologic variables using univariate analyses. NK cell activity was significantly decreased in all patients with penile carcinoma when compared with the control groups (p < 0.0001). There was no statistically significant difference between the groups with and without metastasis. We conclude that there is a decrease in NK activity in PBMCs from patients with penile carcinoma and that the presence of advanced disease or metastatic involvement is not responsible for this reduction.Natural Immunity 01/1998; 16(5-6):256-62. DOI:10.1159/000069451
Article: Andrei Sulica, MD, 1938–2000Natural Immunity 01/1998; 16:176-177. DOI:10.1159/000069443
Article: Autoantibody level modification in adult patients with idiopathic thrombocytopenic purpura following intravenous immunoglobulin treatment.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to determine whether treatment of patients with immune thrombocytopenic purpura (ITP) with intravenous immunoglobulin (IVIg) is associated with a modification in the antiplatelet glycoprotein (GP) antibodies (Abs). Fourteen patients with ITP (11 females and 3 males, mean age 36.6 years, range 18-72) received one to four IVIg treatment courses. The preparation used was ISIVEN that was given in a dose of 2 g/kg body weight in a 5-day schedule and in monthly intervals. Levels of IgG, IgM and IgA isotypes of Abs to GPs IIb/IIIa and Ib/IX were measured before the treatment, and before and after each treatment course. Two patients did not respond to IVIg, 6 had a temporary response, 5 had a sustained response and 1 patient responded well to the treatment but was lost to follow-up. The patients had a high prevalence of serum Abs directed against GPs IIb/IIIa and Ib/IX before the treatment, and the mean IgG isotype levels of both Abs increased after each treatment course, and decreased again before the following course began. Whenever high Ab levels of either isotype (> 10 U/ml) were detected before the treatment, they were significantly decreased before the last treatment course. The elevated levels of IgG Abs to IIb/IIIa and Ib/IX after every course are probably a result of displacement of these Abs from Fc receptors by the IVIg, rather than of exogenous infusion of these Abs contained within the IVIg, whereas the decrease in high Ab levels after a few treatment courses results from the immunomodulatory effects of IVIg: suppression of Ab formation, and the presence of anti-idiotypes.Natural Immunity 01/1998; 16(5-6):207-14. DOI:10.1159/000069447
Article: Natural killer cell frequency and function in Yorkshire pigs selectively bred for high or low antibody and cell-mediated immune response.[Show abstract] [Hide abstract]
ABSTRACT: Porcine NK cells are small to medium-size lymphocytes having a variety of functions that may include the regulation of immune response. Thus frequency and function of NK cells were examined in generations 6 and 8 (G6, G8) of pigs selectively bred for high (H) and low (L) antibody and cell-mediated immune response (CMIR). Using the monoclonal antibody 5C6 as a pan NK phenotype marker and target cell binding and lysis as assays of function, it was found that H and L immune response pigs had high and low NK cell frequency, respectively, at G6 and G8. Function of NK cells differed by line, with the control (unselected) pigs being higher (with respect to target cell binding) or similar (with respect to lytic activity) to H which were higher than the L line pigs. Frequency of NK cells after primary immunization was in significant negative correlation with antibody after secondary immunization with hen egg white lysozyme (HEWL). Therefore, simultaneous selection for antibody and CMIR altered the frequency and function of NK cells in pigs with C > or = H > L.Natural Immunity 01/1998; 16(4):127-36. DOI:10.1159/000069437
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.


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In the run up to the general election in May we are asking all MPs a simple question: Do you support nurses? We have written to each and every one of them calling on them to support our Safe Staffing Alliance manifesto which sets out the key issues on safe nurse staffing.
Our manifesto makes it clear that one registered nurse to eight patients, plus a nurse in charge (during the week) is unsafe, and not a satisfactory minimum staffing level. Missed care occurs at one nurse to seven patients, so a lower ratio is needed.
Evidence shows that 45 per cent of wards in England are operating at unsafe levels. When you add the 27 per cent drop in district nurse numbers over the past four years, and the fact that 25 per cent of nursing directors are only in post for one year, it is little wonder the health service is in meltdown.
The NHS needs a reboot. Trust chief executives across the UK should each declare a week-long internal major incident to put the focus back on patient flow. In trusts where this has already happened, directors have been hands on in leading the initiative, working closely with community services, while non-clinical staff volunteered to support clinicians.
The result has been 85-90 per cent bed occupancy, no so-called 'bed-blockers', no cancelled elective operations, A&E targets met, patients discharged before noon, equipment fixed, staff smiling, improved patient experiences and our cherished NHS restored to normality.
The way forward is clear: we need effective planning of care and the workforce, clear and recognised standards, and transparency in the system. Employing sufficient nurses and midwives to ensure that patients are treated with dignity and respect should be viewed as an investment, not a cost.
Please take a moment to sign up in support of our campaign or you can download our Never More Than 8 leaflet here.
Also you can read our response to the NICE staffing guideline consultation.
Susan Osborne
Chair, Safe Staffing Alliance
Patients are sicker than ever before. The Safe Staffing Alliance believes that meeting those patients' needs through compassionate care can only be achieved by adequate nurse staffing levels. Given the compelling evidence of a link between registered nurse (RN) numbers and quality of care, ensuring there are sufficient nurses, in all areas of service provision, is a priority.
Members of the Commons health committee were among MPs and peers who signed up to the safe staffing campaign at a reception at the Houses of Parliament.
In addition to these organisations, the Safe Staffing Alliance also has the support of a number of individuals. Find out about them.
The Safe Staffing Alliance has brought together some of the vast body of evidence that staffing levels are linked to quality.
The Alliance is made up of nurse leaders who came together as part of the Nursing Standard / Patients Association Care campaign.
Find out about our organisation and the arguments for safe staffing levels.
We emailed all MPs with a copy of the Safe Staffing Manifesto and asked them: Do you support nurses?
Here are the MPs who responded...
We would like to hear what's going on in your area so we have an up-to-date picture of the staffing situation nationally.


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Planned Parenthood embraces more gendercide: The monstrous consequences of "non-judgementalism"
Lila Grace Rose and Live Action are once again exposing the gendercide-endorsing zealots of Planned Parenthood. This time, it's PP staff in Hawaii who blithely encourage and coddle a young girl who tells them she wants to abort her unborn baby girl because she's the wrong sex.
Watch as the PP staff condemn a doctor for questioning the sex-selection scheme and champion taxpayer-subsidized sex-selection murder:
Much more at Live Action.
Sign this petition to Protect Our Girls.
Posted in: Abortion
Open thread: 'Pro-abortion progressive laments Tsarnaev death sentence' edition
May 17, 2015 11:19 AM by Doug Powers
Mother's Day open thread: Mark Halperin embarrassingly tests Ted Cruz's Cuban cred; Al Gore finds religion
May 10, 2015 12:45 PM by Doug Powers
Just great: Hillary Clinton dusts off 'It Takes a Village'; Says '**every life matters'
April 30, 2015 06:47 AM by Doug Powers
Hillary: Killing unborn babies will never be copacetic until you clingers let go of your religious hangups
April 25, 2015 05:58 AM by Doug Powers
The Crusade continues: Obama defers further criticism of 'less than loving' Christians for another day
April 7, 2015 11:58 AM by Doug Powers
Categories: Abortion, Al Qaeda, Barack Obama, Islam


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Martin Handley presents Leonard Bernstein's comic operetta Candide, recorded at London's Coliseum in July. Robert Carsen's controversial production for English National Opera updates Voltaire's savage 18th century satire from Europe to the Unites States of the 1950s, revealing the dystopian reality of the American Dream.
Voltaire/Pangloss/Martin: Alex Jennings
Candide: Toby Spence (tenor)
Cunegonde: Marnie Breckenridge (soprano)
Old Lady: Beverley Klein (mezzo-soprano)
Grand Inquisitor/Captain/Governor: Bonaventura Bottone (tenor)
Paquette: Mairéad Buicke (soprano)
Maximilian: Mark Stone (baritone)
Cacambo: Ferlyn Brass
Rumon Gamba: Conductor
Orchestra and Chorus of English National Opera
Act I
In Westphalia, Maximilian and Cunegonde, the children of the most powerful baron in the country, live in perfect harmony with their chambermaid Paquette and their poor relation Candide. They are tutored by Doctor Pangloss, who teaches them that 'everything is for the best in this best of all possible worlds'. But one day Candide is caught kissing Cunegonde and is thrown out.
He becomes a soldier, but is soon accused of desertion and sentenced to death, only to be pardoned at the last minute. War breaks out in Westphalia. As the fighting subsides, Candide discovers Cunegonde's body among the dead, and also finds his old teacher Pangloss, who is suffering from syphilis.
James, an Anabaptist, offers to help find a cure for Pangloss and suggests that they all set sail on his ship. But James's ship sinks, which doesn't stop Pangloss from insisting that everything is still for the best. As Candide and Pangloss manage to reach dry land an earthquake flattens the entire country, killing thousands. Pangloss and Candide are arrested and accused of being responsible for the catastrophe. An auto-da-fé is ordered to avoid any further disasters. The defendants are brought before the court, tried, and sentenced to death by hanging.
Cunegonde miraculously survived her death in Westphalia and has now begun to regain her previous quality of life. She shares herself between two rival protectors, Don Issachar and Don Cardinale. In order to make sure that the two men never meet, she relies on the help of an Old Lady with a mysterious past. Candide (who has miraculously survived being hanged) is amazed to discover that Cunegonde is alive and well. As they fall into each other's arms, Don Issachar appears and insults Cunegonde. Candide kills him. Don Cardinale then appears, and the same fate befalls him. Encouraged by the Old Lady, Candide and Cunegonde decide to flee. With the help of a Captain, they all set sail for the New World, in search of a better life.
Act II
Candide, Cunegonde, the Old Lady and Cacambo (a Native American Indian recruited by the Captain to help Candide on his travels), arrive in the New World. The Officer who selects the immigrants is immediately attracted to Cunegonde. Cacambo informs Candide that even in the New World he is still wanted for murder. They have no choice but to leave Cunegonde behind and flee once again.
As they begin their travels, Candide and Cacambo come across a religious group which includes Maximilian. Recognizing Cunegonde's brother, Candide tells him that his sister is still alive and that he intends to marry her. When Maximilian opposes this idea, an argument breaks out and Candide kills Maximilian. Yet again Candide and Cacambo are forced to flee. Discovering Eldorado, Candide becomes incredibly rich, but he is unable to enjoy his new-found wealth by himself. He sends Cacambo back to try and find Cunegonde, while he looks for a ship to take them all to safety.
During his search, Candide meets Martin, a poor man who is as pessimistic as Pangloss is optimistic. Martin tells Candide that the world is a horrible place, full of horrible people. In spite of this new lesson, Candide puts his trust in a greedy businessman, Vanderdendur, who pretends to help Candide while selling him a leaky boat and stealing all his money. The boat sinks, but Candide finds his stolen money floating on the water along with the half-drowned Pangloss (who has also miraculously survived being hanged), who continues to repeat his mantra of optimism.
They end up in a casino where Paquette and Maximilian (who has miraculously survived being killed by Candide) also work. Ragotski, the owner of the casino, encourages Cunegonde and the Old Lady to use their charms to steal Candide's money. Cunegonde's mask falls from her face, and Candide is forced to recognize that she is not the faithful woman he always imagined her to be. He further realizes that human happiness is to be found neither in Pangloss's unconditional optimism nor in Martin's die-hard pessimism, but somewhere in between.
Candide concludes that it would be best to try and 'make our garden grow'...
©Robert Carse


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Hebrew for "home," Bayit is an independent organization that gathers together a diverse community of Evanston, Chicago and Skokie children and families at a daily afterschool program that echoes the Jewish summer camp experience.
We believe that all children deserve the opportunity to participate in activities that help them explore their Jewish identities.
Every school day, the warm, welcoming professionals at our positive afterschool program create an environment where children can experience Judaism, build confidence, and develop life-long friendships.
Visit our Program page for more information about our project-based, community approach.


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with everything going to a Pixar theme, I can see the old People Mover being themed to The Incredibles... remember the "bubble tram" on the island; a perfect modern version of the People Mover!
with everything going to a Pixar theme, I can see the old People Mover being themed to The Incredibles... remember the "bubble tram" on the island; a perfect modern version of the People Mover!
But that's the fault of individual idiocy, not the ride itself. I get the feeling that CalOSHA goes overboard sometimes.
At WDW it is FAR easier to jump out of your TTA PeopleMover vehicle as you aren't being locked in a "caged" vehicle, but when was the last time you heard of any issues with that?
That said, would anyone seriously suggest sticking mechanical motors and rubber tires in the track again? There's hardly anything "tomorrow" about it. Future of mass-transit will be more reliant on forms of transportation that don't require as much mechanical operation and minimize friction.
If today's Disney and Bob Iger wanted to leave a real, lasting legacy, they'd seriously consider investing the $1 billion or whatnot that the PeopleMover would cost to reinvent. From the ground up. Tear down the leaf-strewn, ugly, abandoned tracks and start all over again. Why?
Because the future is here and it's not what we thought it would be. THIS IS NOT A POLITICAL STATEMENT: The future of our cities depends on mass transportation, and no one has figured out a system that meets with widespread acceptance. The PeopleMover could, as it was in the 1960s, be a visible demonstration of how creativity, imagination and ingenuity can solve the problems we face.
Disney has become an entertainment company without peer, but it is ONLY an entertainment company. It no longer innovates or stretches itself. A completely re-thought PeopleMover could be a showcase for a world of tomorrow, a system like the first one that exists in "miniature" to show what could work in a real-world setting for the future.
They could extend it so that you have an option to ride a "fun" PeopleMover INSIDE the park and a "real" PeopleMover between the Esplanade and the parking garage.
It would cost a fortune. No company could build it ... except Disney.
No, I know it's not to be ... but imagining a world where the impossible is possible, where Disney creates entertainment AND revolutionizes the world, that's sort of fun.
I think ripping out the PeopleMover isn't a bad idea. The neat thing about that particular ride is that it was above everything else! Made great use of 3D space as opposed to most theme parks. Along those same lines, if I was anyone with power at Disney *and* had an unlimited budget I would make the following changes:
- Rip out the PeopleMover and replace it with a new ride that goes above Tomorrowland. Something easy and transportation related. Possibly a zero friction transport tube (cool) or some very next gen thinking kind of item that would bring you around the park / Tomorrowland in interesting ways, but above everyone else.
- Rip out the current monorail and replace it with a PRT system (or similar) for actually transporting guests not just acting as a ride. The PRT would have stations at the parking structure, Toy Story lot, Pumbaa lot, Cast Member Lot, Anaheim Train Station (next to the Anaheim Angles stadium) and possibly even at Garden Walk (although that one is very questionable). A future expansion would have the line go all the way to LAX and/or the Orange Airport so you could fly in and be right on your way to Disney. The PRT would swing through each of the parks depending on where you're coming from, but stop outside at the Esplanade somewhere. There should also be a stop at each side of Downtown Disney. More info on PRT here: Personal rapid transit - Wikipedia, the free encyclopedia
- Get rid of Autpoia (not really a 'tomorrow' kind of ride, and really anyone can drive a car now) and replace it with something like Mission: Space. This will likely be an unpopular decision, but I think having some really awesome space based stuff in tomorrowland would be fun.
- Get rid of Innoventions completely. I believe Disney owns the rights to Marvel, so I would suggest instead turning that area in to Stark Expo 2012 (and increment the number each year). This is the ginormous forward looking fair that they had in the Iron Man movies. This probably goes against the Disney grain, but give companies free access to display uber modern technology in here for 3 to 12 months at a time. That keeps the technology new and fresh and gives companies a great way to advertise within Disney. Yeah, I know dreaming. Anyhow, if you have forgotten about Stark Expo, check this out: Stark Expo 2010 : Better Living Through Technology
- Get rid of Astro Blasters. We already have Toy Story in the other park, don't need two of these rides. Instead make this a ride about particle physics or similar. Do something fun here!
I have a few more ideas, but figured I would post these and let the community either love it or hate it. Would love to hear what I can tweak in my personal Tomorrowland master plan to make it even better, or what I got wrong and should be reconsidered.
snopes.com: Disneyland Deaths
Not only that, but this could EASILY be remedied by changing the car design to have bars or cages, much like open air gondolas on ferris wheels or sky trams. Death by crushing is NOT why they are closed or not coming back, so let's not get that rumor running rampant.
As for the subs, where in the heck did that rumor even come from? They just refurbished them to great fanfare a few years ago. Why would anyone think they would get rid of them now?
So what are they going to do with the track and that stupid antenna thing?
But that's just my point - where is the Disney ingenuity? Granted safety and building standards are more stringent, but if Imagineering was worth it's salt it would find ways to accomodate those standards and still deliver the magic. OSHA's guidelines are good for Disney in that they help the company keep out of costly lawsuits, but to use those guidelines as a reason why things can't be done is plain lazy.
Sure I get that but I'm not getting why the fans are being asked to do Disney PR work.Remember that Tony was talking to 400 Disney fans. What a better audience to explain why things are and why some things just can't come back.
Walt may be surprised that some of his attractions are still around after 50 years, but I think he would totally understand why. He used to say that "quality will win out." I don't know that Walt would want evolution at the expense of quality. But that's not the point - the point is that if Walt were still around, you can bet that Imagineering would have had a replacement for Peoplemover long ago - and they certainly wouldn't have left empty, deteriorating tracks for everyone to see.When people want something that is gone to return I think they forget what Walt wanted with his little park. It was to constantly evolve. I have a feeling he would be surprised that some things have been around for 30, 40 and 50 years!
We can only hope for the best - but since we're talking of Walt, I don't think his idea of Tomorrowland being "a living blueprint of the future" will be part of the plans.Who know what might be done with Tomorrowland...I for one can't wait and see what they might come up with. (As long as it isn't blue people :P)
Tear down the castle???? Don't forget, Disneyland is the original! All other parks are the, "also ran" entries! Please, as someone said, the size is in perfect perspective with everything else, like the Matterhorn! Tear down the castle, I can't believe that would even be considered in someone's mind! As for the People Mover, I would love to see it back! I realize the safety issues and other limitations, etc. but as Walt said, as long as there is imagination in the world, Disneyland will never be finished! It CAN be done, get 'er done Tony!!! You charge us $650 a year for a Deluxe pass, most people want it!!!! Do something the people want for a change instead of your "suits" vision of the park. DANG, YOU HAVE THE FREAKING TRACK THERE!!!! Criminy sakes, put the P.M. back or freaking tear down the track/supports! Why have you left it there all these years!!!!!! By the way, I was at Knott's Halloween Haunt a couple years a go and saw Tony and another guy in line for the Mine Train ride and rode in train with him! I said, you look an aweful lot like a Disney imagineer I know of! He said, that is because that's me! I wish I'd run into him now! I'd love to give him my thoughts! : >
---------- Post added 08-08-2012 at 12:56 PM ----------
Amen to all you said! They can do anything, just about but do they want to! Disneyland, it seems has turned into what the powers at be want, is the most financially rewarding and less about Walt's vision and what the public wants! So, all we can do is speak up, make calls, send letters and say how we feel and back it up with spending or not spending money there and let that talk for us also!!!
The Alice in Wonderland ride operated uneventfully for 50 years, then suddenly laws change? The Matterhorn operated safely for 50 years, then suddenly laws change?
Disneyland and The Walt Disney Company need only make an appeal and fight the fight, but its ultra-conservative legal team chooses not to. Disney literally spends millions of dollars a year on lobbying. Lobbying Spending Database - Walt Disney Co , 2012 | OpenSecrets
But when Disney doesn't WANT to do something, it doesn't. No matter what its consumers say or want.
"Greetings, Starfighter! You have been recruited by the Star League to defend the Frontier against Xur and the Ko-Dan Armada."
Although I'm willing to accept the Finding Nemo Submarines are here to stay (with a possible update, for NEMO 2 - because that sells a film like a happy meal @ McDonalds); I think Team Disney Anaheim should redraw the border to Tomorrowland & move that Ride to Fantasyland (its just not a Tomorrowland ride, in my opinion). A better themed Alice In Wonderland railing would be nice (the current CAL-OSHA approved guard rail is fugly, in my opinion!) ...
I want New (& Better) Rides - or Attractions - bringing life back to Tomorrowland (that whole area needs tlc & lots of it before Disneyland's 60th Anniversary in 2015); however it makes me sad that Team Disney Anaheim is letting the idea of a PeopleMover become an "eisner" (a great ride, or attraction that will no longer function due to lack of quality care and / or maintenance). Putting in Rocket Rods may have sounded like a great idea on paper; however that doesn't translate into a real situation without the necessary budget for making sure the ride can operate without causing damage to the existing elevated track ....
What to bring as a new PeopleMover / Tomorrowland Transit Authority for Disneyland? Something that predicts improved Hybrid Technology (ie Electric Vehicles)? Something which hints at a Mass Transit High Speed Bullet Train (mimics the idea without creating a CAL-OSHA headache)? Whatever comes to Tomorrowland, I hope it is with the same thought that an actual ride which takes you through all of Tomorrowland offers a quality experience (& a moment to sit down to enjoy your theme park moment for a good 10 minutes) ....
I <3 Making Friends Who Share The Same Interests :-)


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Friday, 06. September 2013
Save the Date! – First Iberian FSC Business Encounter
The Forest Stewardship Council® (FSC®) is glad to invite you to join the First Iberian FSC Business Encounter in Lisbon, Portugal, on the 21st November 2013. read more …
Thursday, 05. September 2013
FSC represented at the 41st International Forestry Students' Symposium in Madrid
On 14 August 2013, FSC was represented at a conference entitled 'All about Forest Certification'. Organized by the International Forestry Students' Association (IFSA), the … read more …
Thursday, 22. August 2013
Celebrate FSC Friday in Latin America
26-27 September 2013
Lima, Peru
In recent years there has been a steady increase in the use of FSC certified products, both sawn wood and finished products, in the green … read more …
Wednesday, 24. July 2013
FSC's 'In Good Company' Event in Denmark 2013
'In Good Company' is FSC International's annual global conference to engage with the private sector. This third 'In Good Company' event will be hosted by FSC Denmark in … read more …
Friday, 05. July 2013
Save the Date – FSC Friday 2013
27 September 2013 read more …
Thursday, 20. June 2013
Save the Date – FSC® General Assembly 2014
The Forest Stewardship Council® (FSC®) Board of Directors has decided to hold the 7th FSC General Assembly in Seville, Spain, from 7–14 September 2014. read more …


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Wow! Roman is not short on superlatives for this one! First he shows you several positions where the discussion is whether a bishop is good or bad, then you get to see both sides' misunderstanding of this concept. But our author saves his highest opprobrium for a simple pawn move. "This is the worst move I've seen in months." One side clearly wasn't thinking about squares gained and taken away - it turns out to be the pivotal mistake. Enjoy the lesson! | Watch video
GM Dzindzi wants to be a trend setter. For years he has played and studied 3...d6 in the Spanish Game and he can't figure out any clear route to an advantage for White. Today you'll see more of why he thinks top players will eventually switch from the Berlin to the Steinitz. He covers all the missing gaps from part one, including early c3 and c4 systems, as well as similarities to pawn structures from other openings like the Yugoslav attack in the Dragon. Be a trend setter and play the Steinitz! | Watch video
Sure, the Closed Spanish, Open Spanish and Berlin have all been popular at times in the last 30 years, but don't forget about another solid variation against the Lopez: the Steinitz Defense. Players looking for a solid structure with a minimal space disadvantage might just catch their opponents by surprise with 3...d6. Today GM Dzindzichashvili focuses on 4. d4 and both possible recaptures. If it is good enough for a preeminent theoretician, it it surely good enough for you! | Watch video
What happens when a member takes Dzindzi's exact advice in the opening? Watch and see the student imitate the teacher by using an optimistic system versus the French. He's clearly done his homework, but the question is, how will he perform once the theoretical phase ends? As you might guess, not every move is grandmaster level, so watch and see what Roman would have done differently. Let us know in the comments if you've ever had success with this or other Roman systems! | Watch video
GM Dzindzichashvili concludes his Trompowsky Trio with an edition focused on 3. Bh4. He doesn't hide his disdain for the variation but he does caution you about many traps that could befall the unwary player. Black often has open g- and c-files, while White opens his d- and f-files. That's a strange imbalance, but it rewards the more prepared player. Watch and see how Black can attempt to punish White, but take note of the plentiful ways the second player can get mated right out of the opening! | Watch video
GM Dzindzichashvili is not a believer in the Trompowsky. Today he is not satisfied with equality as Black - he wants the computer's evaluation to start with the "minus" symbol! He will walk you through the intricacies of 3. Bf4 and show you positional plans from White and the more popular fighting systems. Have you ever chosen the really smart student as your study partner? That's what it's like getting to hear Roman's analysis! | Watch video
GM Dzindzi starts with a discussion of a trap that nearly everyone falls into! Although it wasn't mentioned, regular Chess.com video author GM Sam Shankland also had it happen to him earlier in 2014. Then we get down to business with an elaborate discussion of how to face the Trompowsky. Our author advocates the 2...Ne4 and 3...c5 system, with the queen venturing all over the queenside. Watch and learn how GMs analyze! | Watch video
Placing your bishop on an inferior square is a recoverable mistake, but opening up your king without reason can be decisive. Today GM Dzindzichashvili shows a game between two experts in the Boleslavsky Sicilian, an opening Fischer, Geller, and Gligoric all essayed (and of course Boleslavsky!). Watch the maneuvering required and the attack White gets with his f4 advance. Dzindzi isn't as critical as in recent videos, so the players must have done something right! | Watch video
The Queen's Gambit Declined. Game doesn't heat up until move 20, right? Not today - GM Dzindzichashvili shows you that some early queen sorties can create dynamic play before either king gets castled. Watch and learn when White or Black can go pawn grabbing, and when the pawns are laced with hemlock. Take the wrong pawn at the wrong time, and Dzindzi will give you a big batch of "I told you so." | Watch video
If the CIA had files on opening theory, then consider GM Dzindzi a latter-day Daniel Ellsburg. He didn't steal the files so much as he wrote them! Today you get the most well-researched look at an opening that Roman doesn't even name. Still, Kasparov and our author have used it. Black goes for center pawn advances at the expense of his king - a high-risk/high-reward endeavor. You'll also see a position that was considered equal until GM Lev Polugaevsky changed everything in one simple stroke! | Watch video
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About me, I am 44, never been married, no kids. No particular aversion to either, but as I alluded in the previous paragraph, things just haven't worked out for me in that way. I've been fortunate enough to have known some lovely women and to have been in some fulfilling relationships. But life being what it is, each of them concluded for one reason or another. In many instances it was due to timing and where each of us was in our respective lives. And in some cases, mistakes were made, sometimes by me and sometimes by her. None of us are infallible, which is something that I've grown to understand over the years. So I carry the scar tissue of loves lost and lessons learned in the crucible of circumstance. But I would have it no other way, as I am in a great place in my life, and would not have arrived here were it not for the multitude of experiences, good and bad, I've had along the way.
While on the surface I appear to to be a linear thinker, and operate in that realm professionally, I have the colorful soul of a creative. Indeed, I love art, and I appreciate artists because I'm not one and am fascinated by what they are able to create from nothing more than an idea or concept. If you truly appreciate beautiful and passionate art- in all of its vibrant colors and varietal of textures- then you already have much more insight into who I am than these few paragraphs will provide.
As for the person I would like to meet… I work very hard in a structured and conservative profession that I love, but it offers no outlet for creativity or artistic endeavor. So, because of my affinity for such things, I tend to gravitate towards women who work in the arts or other professions that make allowances for self expression. Of course, if you are like me and work in the buttoned down world but enjoy playing in the other, I feel that, too. Maybe you have an inner hippie chick that pulls at your heart strings and yearns to be free the moment you leave the office; I understand.
I am a positive person, a natural optimist, and desire the same in a partner. Also, if you are passionate, assertive, and independent...... Well, I've learned to appreciate that these are three of the most alluring qualities any woman can possess. And an axiom comes to mind here- Confidence is sexy; knowing you are sexy is even sexier....
Lastly, a sense of humor is a must, with the ability to laugh at the mundane, as well as find the hilarity in the complex. And if you have a dry sense of humor similar to mine, I can already tell you that our first date will lead to at least one more.


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Hey Dribbblers,
After almost an entire year working on Cardwee, we finally launched last week the company. The time to generate the product has been tough, but we've put all the effort and passion into it, for making our dream come true.
Cardwee takes loyalty cards to the smartphones. Vendors can create real-time promotions who can join the customers when they reach on a shop, and also they can obtain detailed analytics of their trade performance, promotions and customers.
You can follow me on Twitter at @menpalapps or if you want to know the latest news about Cardwee, here is our Twitter.
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text: Tasty Asian Fusion cuisine in a quiet and cozy atmosphere. We ordered the Chicken pad Thai and Cantonese Noodles. Both were very good. The noodles did not taste like they had been sitting out all night. Both dishes were flavorful and we are picky when it comes to our Asian dishes. The menu was... read more


text: Pauly D Opens Up About Baby by Free Britney at November 25, 2013 1:06 pm. Comments Share Tweet Email Pauly D opens up about his baby and being a dad in a new interview. Edit Delete Follow Pauly D? Star: Pauly D Tag: Celebrity Babies Related Videos: Pauly D Videos, Celebrity Babies Videos Related Post: Pauly D Meets Baby Girl For First Time: It Was Amazing! Uploaded by: Free Britney Uploaded: November 25, 2013 Duration: 63 seconds


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Universal Studios Vacation Packages All Inclusive? Yeah, mostly people search for the all inclusive packages to Universal Studios, but the most enthusiasm one for searching adventure to Universal Studios usually are teenagers, so here I am about to give you guys information about Universal Studios Vacation packages all inclusive one for the teenagers.
Yeah, you know that Universal Studios is a paradise for teenagers, where teenagers can find a lot of ride, thrilling effects, scenic backdrops, and many thrilling adventurous to experience, and the Universal Studios Vacation Packages All Inclusive one here, offered you guys to enjoy the rides there without have to wait in line to purchase the tickets. Also the packages you provide you to enjoy several privileges that especially for you guys who bought the packages, and really comfortable accommodation and it is so relaxing. The cuisine provided here are also marvelous and you will get the world's best service is guaranteed.
There if you pay full attention and enjoy everything, you can enjoy a lot of things which needed more than one day to enjoy it. You guys and your family will very enjoy the moment there, For example, for the first, you can pretend to become a reporter which will interview Peter Parker as a Spiderman, then you can enjoy the sensation being in New York in 3D, and there're more, there're villains in the Sequel where you can meet there. Also you can enjoy riding hulk as a coaster, which you will never feel the speed on any other coaster, you can enjoy to become either as a fire or ice dragon, like in the Dueling Dragon Sequels.
So if you are really interested to have Universal Studios Vacation Packages all inclusive, here are several tips for you guys to find a cheap packages:
1. Contact Travel Agency, the travel agency usually bulk the tickets and packages separately and sometimes it's cheaper than usual, and they can inform where the best hotels to stay, and where the good restaurant to eat,
2. Search Online, If you search online on the internet there's a lot of packages offered by online travel agencies which is cheaper than usual.
3. Buy your tickets early, if you really planned to go to Universal Studios, plan it early and you can get the cheapest tickets available there, but if you wait to the last minute to bulk the tickets, then prepare to pay more even pay for premium
4. Travel when the off season, if you travel during the off season, usually the tickets here are cheaper than usual, you can save a lot of bundle, which maybe you can spend on other things.
Universal Studios Vacation Packages All Inclusive are very intimidating packages, I hope this article can help you guys to know more information about the packages, and hope the tips I shared help you guys a lot, which maybe you already know but just to remind you guys. Travel cheap, enjoy it, be happy guys.
Read more Cheap Vacation Packages From Nyc & All Inclusive Resorts In Hawaii to get your another vacation packgaes informations !


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little-cuties.org - Little Cuties
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Domain Name:LITTLE-CUTIES.ORG Domain ID: D160701564-LROR Creation Date: 2010-11-18T10:54:53Z Updated Date: 2014-10-21T19:50:33Z Registry Expiry Date: 2015-11-18T10:54:53Z Sponsoring Registrar:Fabulous.com Pty Ltd. (R133-LROR) Sponsoring Registrar IANA ID: 411 WHOIS Server: Referral URL: Domain Status: clientTransferProhibited -- http://www.icann.org/epp#clientTransferProhibited Registrant ID:c87213ac8888db55more


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Delta CEO objects to TSA allowing small knives
Posted: 03/08/2013 - The CEO of Delta Air Lines is objecting to plans by the Transportation Security Administration to allow small knives back on planes.
Posted: 03/08/2013 - The CEO of Delta Air Lines is objecting to plans by the Transportation Security Administration to allow small knives back on planes.
Updated: 03/08/2013 - It's the weekend to spring ahead for daylight saving time. Most Americans will get an hour less sleep but will gain an hour more of evening sunlight in the coming months.
Posted: 03/07/2013 - The GOP has split over a Republican senator's filibuster of President Barack Obama's CIA nominee and claims about the use of drones in the Unites States.
Updated: 03/07/2013 - Almost 13 hours after he began speaking, Sen. Rand Paul ended his day-long filibuster at 12:38 a.m. today because he had to go to the bathroom. The Kentucky Republican stalled a confirmation vote on CIA Director nominee John Brennan.
Updated: 03/07/2013 - A prosecutor has told a jury that a New York City police officer was a would-be cannibal who was plotting to eat women before his arrest last year.
Posted: 03/07/2013 - A new survey suggests most consumers can't tell legitimate telemarketing calls from cons.
Updated: 03/07/2013 - The founder of a California wild animal park says a worker killed by a lion was a female intern-volunteer.
Posted: 03/06/2013 - Valerie Harper, who played Rhoda Morgenstern on television's "The Mary Tyler Moore Show" and its spinoff, "Rhoda," has been diagnosed with terminal brain cancer.
Posted: 03/06/2013 - A relative of some of the six victims killed in a Kentucky interstate crash says the Wisconsin couple who died was dedicated to raising foster children.
Updated: 03/06/2013 - The Duchess of Cambridge may have inadvertently dropped a hint about the gender of the baby she and Prince William are expecting.
Posted: 03/06/2013 - The double-barreled winter storm that moved through Kentucky is now bearing down on the Mid-Atlantic region.
Updated: 03/05/2013 - Airline passengers will be allowed to carry small knives, souvenir baseball bats, golf clubs and other sports equipment on planes beginning next month.
Updated: 03/06/2013 - Dow Jones industrial average closes at a record high, erasing losses since the Great Recession.
Posted: 03/05/2013 - Emergency officials in a number of states are urging commuters to stay off the roads today and take public transportation to work.
Posted: 03/05/2013 - The Dow Jones industrial average jumped more than 100 points this morning to reach an all-time high
Posted: 03/04/2013 - LEXINGTON, Ky. - Kentuckians might be some of the 'bluest' people in the country, according to a national survey ... and we're not talking about the Bluegrass or the Big Blue Nation.
Updated: 03/04/2013 - Casey Anthony says she doesn't pay rent or utilities and is living off the kindness of others.
Posted: 03/04/2013 - Kentucky freshman Nerlens Noel is among eight players announced by the U.S. Basketball Writers Association (USBWA) as a finalist for the Wayman Tisdale Award, honoring the nation's top freshman for the 2012-13 college basketball season on Monday.
Posted: 03/04/2013 - The child is now 2½ and has been off HIV drugs for about a year with no signs of infection.
Updated: 03/04/2013 - An 87 year old, being cared for at a California retirement facility, died after a nurse refused to perform CPR.
Posted: 03/01/2013 - President Barack Obama has signed an order authorizing the government to begin cutting $85 billion from federal accounts, officially enacting across-the-board reductions that he opposed but failed to avert.
Posted: 03/01/2013 - Florida authorities say a sinkhole that has swallowed the bedroom of Tampa-area house with a man in it is likely to grow.
Updated: 02/27/2013 - A tycoon and space experts have announced an audacious but bare-bones private plan to send a married couple around Mars in 2018.
Updated: 02/27/2013 - Prosecutors say a shooting at a wood-processing company in central Switzerland has left three people dead and seven injured.
Posted: 02/26/2013 - About 80,000 homes and businesses in northwest Missouri, northeast Kansas and western Oklahoma awoke to no power.


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With water-cooling support, tool-free trimmings and excellent-looking cable routing, could the PC-B16 (right) and PC-161 (left) be a return to form for Lian Li?
Originally Posted by AlienwareAndy
Silver insides? how 2001. Seriously, Lian Li need to give their designers a slap.
Hex Gear R40 Preview Build
25th June 2015
SilverStone Kublai KL05 Review
25th June 2015


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KSPS FitKids Day Member Meet n' Mingle 2015
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KSPS Take A Peek
KSPS Public Television
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KSPS Public Television serves US and Canadian citizens with programs offering new discoveries, diverse opinions, world news and first-class entertainment thanks to support from our viewers, the Friends of KSPS. Tune in for life-long learning opportunities.
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This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
Recent Victoria reviews
"My husband and I have been coming to Jim and Judy's spectacular waterfront home for 6 weeks every spring, for 5 years now. We have enjoyed it's wonderful location for water sports (kayaking and fishing), golfing at nearby courses, biking the fabulous trails found on the peninsula and general enjoyment of the scenery and wildlife viewing. The home is so well appointed that we felt instantly at home. We have no reservations about giving this property our highest recommendations."Guest: Carol and Brian Date of Stay: May 2015 Review Submitted: June 24, 2015View listing
"My husband, his sister, her fiance, and me stayed in this amazing condo right in downtown Victoria. It was the perfect place to getaway with great views of Parliament. Everything was easy walking distance and the concierge who met us upon arrival was wonderful, full of wonderful inside information about the city."Guest: mallori h. Date of Stay: August 2014 Review Submitted: September 4, 2014View listing
"Hi Steve and Trish, Just thinking about the month of October and our stay at the condo. We couldn't have wished for better accommodation. As always, the condo made our stay a memorable one. So close to everything and we must say the condo building was quiet and well cared for. Thank you for everything. Merry Christmas to you both Bob and Enid"Guest: Bobo Date of Stay: September 2014 Review Submitted: December 23, 2014View listing
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Featured Destinations: The Villages, Rosemary Beach, Destin Condo Rentals, Amelia Island, Myrtle Beach, Outer Banks


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A mystery most sinister and some say supernatural. But the detective doesn't believe in such things. When you've eliminated the impossible, whatever is left no matter how improbable must be the truth.


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Aliases for GATA6 Gene
Aliases for GATA6 Gene
External Ids for GATA6 Gene
- Entrez Gene: 2627
- Ensembl: ENSG00000141448
- UniProtKB: Q92908
Summaries for GATA6 Gene
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
GeneCards Summary for GATA6 Gene
GATA6 (GATA Binding Protein 6) is a Protein Coding gene. Diseases associated with GATA6 include atrial septal defect 9 and atrioventricular septal defect 5. Among its related pathways are Heart Development and Hemostasis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein kinase binding. An important paralog of this gene is GATA5.
UniProtKB/Swiss-Prot for GATA6 Gene
Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).


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I can only go back 6000 years, early then that there wasn't anything. No universe,no time, no space no DNA.<quoted text>"Universal Common Descent" as in all life on Earth came from the same microscopic parents if you go back far enough in time. Monkeys and Apes are our cousins.
Just plan old nothing.
You can be a cousin with anything you wish. All of my cousins are human just like me. No apes here.