text:
|Kôji Fujiyama
|Dr. Tom Wallace
|Daigo Inoue
|Reiko Kasahara
|Kiyoko Ishikawa
|Daihachi Kita
|Goro Kumon
|Shin Minatsu
|Akira Natsuki
|Kei'ichi Noda
|Jigura (Japanese version) (voice)
|Isamu Saeki
|Dr. Yosuke Ishikawa
|Yasushi Sakagami
|Kenichi Ishikawa
|Mikiko Tsubouchi
|Mrs. Ishikawa
|Eiko Yanami
|Woman X / Chikako Sugawara
|Yoshio Yoshida
|Arlene Zoellner
|Margie Wallace
|Gloria Zoellner
|Helen Wallace
Directed by
|Noriaki Yuasa
Writing credits(in alphabetical order)
|Niisan Takahashi
|(as Fumi Takahashi)
Produced by
|Sandy Frank
|producer (US version)
|Yoshihiko Manabe
|Hidemasa Nagata
Original Music by
|Shunsuke Kikuchi
Cinematography by
|Akira Uehara
Film Editing by
|Yoshiyuki Miyazaki
Production Design by
|Akira Inoue
Art Direction by
|Tomohisa Yano
Second Unit Director or Assistant Director
|Masami Akise
|assistant director
Sound Department
|Hideo Okuyama
Special Effects by
|Kazufumi Fujii
|special effects director
|Ryosaku Takayama
|monster design
Camera and Electrical Department
|Heihachi Kuboe
|lighting technician
My Take: Toho could make art compared to this.
The giant rubber monster movies, or Kaiju as they called it in Japan, has been on the spotlight for many a year. From the fame of "Gojira" or "Godzilla: King of the Monsters", the same studio tried to top themselves with creating more and more of this monstrosities battling each other. "Godzilla", the most famous of these, also spawned rip-offs (They happen here to you know). One of these was Gamera. from the original "Gammera the Invincible", this also spawned sequels, which features our giant rubber terrapin pits fire against other giant monsters, and always impresses the kiddies, who look up to Gamera as their hero. While the other Gamera films maybe are entertaining (haven't seen them yet), "Gamera vs. Zigra", the last in the series is what I'd include in the category "Bottom-of-the-barrel". LAughable rubber monster movie. They would have learned from the start that this was silly. But no, they made it anyway.
The plot is mainly the basis of hundred previous Kaiju films. Alien entities try to take over the world. Led by Zigra, an alien lord resembling the Goblin shark, which can be found commonly near Japanese waters, the alien enemy (well, only one) cause massive earthquakes to prove their powers. Then the kids point at the skies as their hero approaches. Is it Superman? No, it's Gamera!!! Yes Gamera to the rescue once again. And Gamera does more than fight Zigra, he does many other silly things like breath fire...underwater(?!)and so much more. If you think that would be silly, wait 'till you see it.
This is admittedly one of the silliest movies I've seen in a while (although I have a hunch saying I'll be seeing more of this silliness with these rubber monster Kaiju), but some movies have reached a certain amount of ineptness, being Ed Wood's "Plan 9 from Outer Space" as a good example, that they can be entertaining, mostly for preposterous reasons. Camp buffs can rest their eyes on preposterous situations like fire-breathing underwater, an alien woman walking about wearing only a bathing suit as a disguise, silly dialog and, well, so much more than you can possibly laugh at, unintentionally.
Although this was indeed silly, at least it didn't bore me, I mean, with all the silliness going on. I give the film, at least, a *, for being completely hilarious on the parts that it shouldn't.
Rating: * out of 5.
|Gamera vs. Guiron
|Destroy All Monsters
|Gamera vs. Viras
|Daikaijû kûchûsen: Gamera tai Gyaosu
|Daikaijû kettô: Gamera tai Barugon
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|Company credits
|External reviews
|News articles
|IMDb Action section
|IMDb Japan section


text:
Obey 89 Burgundy T-Shirt
Item # 222258
Buy1 Get1 Free
Stash Points: 998
What is this?This is the number of points you get in The Zumiez Stash for purchasing this item. Stash points are redeemable for exclusive rewards only available to Zumiez Stash members. To redeem your points check out the rewards catalog on thestash.zumiez.com.
Step into a simple look that has no shortage of style in the Obey 89 crew neck t-shirt for girls.
|More Details

subset: commoncrawl


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Simulator helps Neb. cops train for real-life scenarios
The high-tech training program teaches cops how to make better decisions
Lincoln Journal Star
LANCASTER COUNTY, Neb. — Lancaster County Sheriff Terry Wagner points his gun at the suspect in the warehouse and tells him to show his hands.
"I work here," says the man, keeping one hand behind a box.
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Full story: Simulator helps Neb. cops train for real-life scenarios
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Come on! Join the party
Burma's festive spirit is its greatest charm. There are always parties, from shin pyu ceremonies, when young boys traditionally join a monastery, to nat pwes, or local spirit rituals, and pagoda festivals. The biggest is Thingyan (the water festival) for Burma's New Year (13-16 April). In rural areas, the old year is washed away with splashes of scented water, but in the cities huge spraying platforms (pictured) are erected and passers-by are drenched from fire hoses. Burma's most spectacular event is at Inle Lake, where the Phaung Daw Oo pagoda festival (5-22 Oct) sees Buddha statues taken around the lake in a gilded barge shaped like a mythical bird.
© independent.co.uk


text:
We need to pay much more attention to cardiovascular disease in pregnant women.
However, this increase was nearly completely due to cardiovascular disease.
It cuts down on the risk of cardiovascular disease, and doubles the deliciousness.
cardiovascular car·di·o·vas·cu·lar (kär'dē-ō-vās'kyə-lər)
Abbr. CV Of, relating to, or involving the heart and the blood vessels.
A descriptive term for the heart and the blood vessels.


text:
|Men's College Basketball
· Coaching changes
· Conferences
· Conference stats
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· Injuries (A-M)
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· News
· Current odds
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More Basketball
· Women
The Sports Network
DATE & TIME: Tuesday, December 4, 7:30 p.m. (ET)
FACTS & STATS: Site: Petersen Events Center (12,508) -- Pittsburgh, Pennsylvania. Television: ESPNU. Home Record: PSU 4-1, Pitt 4-0. Away Record: PSU 1-0, Pitt 0-0. Neutral Record: PSU 1-1, Pitt 3-0. Conference Record: PSU 0-0, Pitt 0-0. Series Record: Pittsburgh leads, 75-70.
GAME NOTES: The Pittsburgh Panthers will attempt to keep their unblemished mark alive at home on Tuesday night, as they welcome the Penn State Nittany Lions to Petersen Events Center as part of the Big Ten/ACC Challenge.
Penn State has played very well in the early going this season, as its 6-2 record marks its best start since opening up 7-1 in 2008. The Nittany Lions partook in last weekend's Barclays Classic, but after advancing to the championship game with a win over St. John's in the semifinals, 89-82 in overtime, they fell short of Ole Miss, 79-76.
Pitt also participated in a November tournament at the Barclays Center, as it dismissed Texas Tech (76-53) and Stanford (88-67) en route to the Legends Classic championship. The Panthers continued their perfect season on Nov. 30 in their annual bout with cross-town rival Duquesne, 84-67, to run out to a 7-0 start for the eighth time in the last 13 seasons.
These Keystone State rivals are very familiar with one another having played 145 times before, although they have not met up in eight years. The Panthers hold a slim 75-70 advantage.
The Nittany Lions trailed by as many as 13 in their latest game with Ole Miss, and even though they were able to climb back and take a seven-point lead midway through the second quarter, their advantage would not last long as the Rebels pulled away late. While they completed greater than 47 percent of their field goal attempts on the night, including 9-of-22 from beyond the arc, they had a disappointing showing at the foul line (11-of-18). D.J. Newbill shined in the setback with 23 points. Ross Travis tallied a double-double with 17 points and 13 rebounds, while Tim Frazier narrowly missed one with nine points and 10 assists. On the season, Penn State has typically been impressive on offense, shooting just a shade under 48 percent from the field for 82.2 points per game, good for a +10.4 scoring margin. Newbill (19.5 ppg, 6.9 rpg) and Frazier (18.5 ppg) are both elite scoring options, while Frazier also gets his teammates involved with 7.5 assists per game (fifth in the nation). Brandon Taylor (12.0 ppg) and Travis (11.6 ppg, 8.3 rpg) have also been solid.
Although the Panthers found themselves tied with Duquesne early in the second half, they caught fire from there and led by as many as 20 points down the stretch. They shot nearly 50 percent from the field, even though only 3-of-16 came from 3-point range, and they took care of the basketball with just seven turnovers. Cameron Wright led the way with 20 points and five assists, while Lamar Patterson stuffed the stat sheet with 18 points, eight rebounds, six assists and five steals. Talib Zanna and Durand Johnson netted 13 and 11 points, respectively, while James Robinson pitched in eight points and nine assists. As its record would indicate, Pitt has been dominant on both ends of the floor this season, as it posts eye-popping margins in terms of scoring (+23.7), rebounding (+12.7) and turnovers (+4.6). At least seven players score at least 6.1 points per game, led by Patterson (17.1 ppg, 4.9 rpg, 5.4 apg). Zanna (12.7 ppg, 6.8 rpg) is a steady presence in the paint, while Wright (11.4 ppg) and Johnson (10.3 ppg) are also off to great starts.
Despite Penn State's impressive start to the season, it will certainly have its hands full in this one playing on the road against a surging Panthers team. Pitt many not experience the blowout victory it has gotten used to this season, but it still shouldn't have much issue dismissing its intrastate rival.
Sports Network Predicted Outcome: Pittsburgh 80, Penn State 68
Powered by The Sports Network.


text:
A method as described for testing the susceptibility of a person to asthma. The person inhales an effective amount of sodium chloride, mannitol or another substance capable of altering the osmolarity of airway surface liquid in the subject. The substance is in the form of a dispersible dry powder containing an effective proportion of particles of a respirable size. The subject is then measured to detect airway narrowing which is indicative of a propensity for asthma. The same technique of dry powder inhalation can be used to test for the susceptibility of a person to rhinitus, to induce sputum and promote mucociliary clearance.
1. A method for attempting to provoke airway narrowing in a subject comprising the steps of (a) causing the subject to inhale into subject's airways an effective amount of a substance capable of increasing the osmolarity of airway surface liquid in the subject, which substance is in the form of a dry dispersable powder, other than a dry powder dissolved in a liquid, containing an effective proportion of particles of a respirable size, and (b) measuring in the subject a parameter indicative of the resistance to air flow of the subject's airway.
2. A method as claimed in claim 1 in which the subject is caused to inhale the substance into the airways of a lung.
3. A method as claimed in claim 1 in which the subject is caused to inhale the substance into a nasal airway.
4. A method as claimed in claim 1 in which the substance is selected from the group comprising mineral salts, sugars and sugar alcohols.
5. A method as claimed in claim 4 in which the substance is selected from the group comprising salts of sodium or potassium, hexose and pentose sugars and their corresponding sugar alcohols.
6. A method as claimed in claim 5 in which the substance is selected from the group comprising sodium chloride, potassium chloride, mannitol and dextrose.
7. A method as claimed in claim 1 in which an effective quantity of the dry particles have a maximum dimension of seven microns.
8. A method as claimed in claim 1 in which the proportion of the particles having a respirable size is at least 10% by weight of the substance, preferably at least 25%, more preferably at least 40% and most preferably at least 50%.
9. A method as claimed in claim 1 in which the parameter indicative of airway narrowing that is measured comprises measuring a reduction in forced expiratory volume in one second.
10. A method as claimed in claim 1 in which the substance is packaged in a rupturable hard capsule.
11. A method as claimed in claim 10 in which the capsule contains from 1 to 100 mg of the substance, preferably 5 to 40 mg.
12. A method for increasing mucociliary clearance or inducing sputum comprising the step of causing a subject to inhale into the subject's airways an effective amount of a substance capable of increasing the osmolarity of airway surface liquid, the substance being in the form of a dispersible dry powder, other than a dry powder dissolved in a liquid, containing an effective proportion of particles of a respirable size.
13. A method as claimed in claim 12 in which the subject is caused to inhale the substance into the airways of a lung.
14. A method as claimed in claim 12 in which the subject is caused to inhale the substance into a nasal airway.
15. A method as claimed in claim 12 in which the substance is selected from the group comprising mineral salts, sugars and sugar alcohols.
16. A method as claimed in claim 15 in which the substance is selected from the group comprising salts of sodium or potassium, hexose and pentose sugars and their corresponding sugar alcohols.
17. A method as claimed in claim 16 in which the substance is selected from the group comprising sodium chloride, potassium chloride, mannitol and dextrose.
18. A method as claimed in claim 12 in which an effective quantity of the dry particles have a maximum dimension of seven microns.
19. A method as claimed in claim 12 in which the proportion of the particles having a respirable size is at least 10% by weight of the substance, preferably at least 25%, more preferably at least 40% and most preferably at least 50%.
20. A method as claimed in claim 12 in which the substance is packaged in a rupturable hard capsule.
21. A method as claimed in claim 20 in which the capsule contains from 1 to 100 mg of the substance, preferably 5 to 40 mg.
The present invention relates to a method and device useful to provoke airway narrowing and/or the induction of sputum. More particularly the invention relates to the use of dry powdered substances to induce a change in the osmolarity of the airways to induce narrowing and/or the induction of sputum.
Asthma is a chronic inflammatory disease of the airways resulting in bronchial hyperresponsiveness to a wide variety of chemical, physical, and allergenic stimuli. This sensitivity is manifested by narrowing of the airways and a reduction in the forced expiratory volume in one second (FEV1). Bronchial provocation testing, measuring changes in FEV1 in response to inhaled stimuli, is well established as a technique for identifying and assessing the severity of airway hyperresponsiveness in persons suspected of having asthma (J Allergy Clin Immunol 1979; 64:1-250, Sterk et al Eur Respir J 1993,6(Supp 16):53-83. The most commonly used provocative agents are histamine and methacholine that act directly on specific receptors in the airways causing bronchial smooth muscle contraction. Challenges with these agents have a high negative predictive value but a low specificity for asthma when performed in a random population. Recently there have been problems with availability of these agents and accreditation for their use in humans. Currently the only product approved for human use by the Federal Drug Administration in the USA is Provoline (Hoffman La Roche) which is methacholine chloride.
Bronchial provocation testing with dry powders containing respirable particles of allergens (e.g. flour, red cedar wood dust, resins, gums) has also been used to identify specific allergens in order to establish a relationship between exposure to the suspected agent and the onset of asthma. These are most commonly used to investigate occupational asthma.
In the last 10 years the inventor's laboratory has developed and standardised a bronchial provocation test using wet aerosols of hyperosmolar saline generated by an ultrasonic nebuliser (Anderson et al., in Provocation Testing in Clinical Practice, pp 249-278, Marcel Dekker Inc. 1994). This test is now well established in Laboratories throughout Australia and is listed in the Medical Benefits Schedule Book. This challenge test is also included in the report of the working party of the European Community for Steel and Coal (Sterk et al., Eur Respir J, 1993,6(Supp 16):53-83). It has recently been recommended by the Bronchial Provocation Committee of the International Study of Asthma and Allergy in Children.
Hyperosmolar saline challenge appears to be a very useful technique to identify persons with current asthma and those who suffer exercise-induced asthma. It is also very useful to evaluate the drugs used in the treatment of asthma.
The major disadvantage of using wet aerosols of hyperosmolar saline is that an ultrasonic nebuliser is required and this is expensive. Another disadvantage is that ultrasonic nebulisers require maintenance for cleaning and sterilisation. Further a weighing machine is required to measure the output for each test as the nebulisers differ in output over time and between machines. Another disadvantage, as with other wet aerosols, is that the person administering the challenge is also exposed to the aerosol as more than half of the amount generated by the nebuliser is expelled into the environment. Further the personnel are also exposed to saliva from the patient. There are also some difficulties encountered by the patient and these include the use of a nose peg, the production of a lot of saliva and the taste of salt. The time taken to perform the challenge with a wet aerosol in a mild asthmatic or healthy control maybe 70 minutes. This comprises preparation of solution and apparatus (about 10 minutes), actual challenge time which for mild asthmatics may be up to 30 minutes, and finally post challenge cleaning and sterilisation (about 30 minutes).
It is also known that wet aerosols of salt can be used for the purpose of increasing mucociliary clearance and inducing sputum in a subject. This technique has been used since the 1970's by physiotherapists to enhance the clearance of secretions from the airways of subjects having cystic fibrosis and bronchitis. In recent years the technique has been used with patients with HIV who are suspected of having Pneumocystis carinii which causes pneumonia and needs to be treated. Sputum analysis in patients suspected of having tuberculosis is also known as a simple technique to look for the disease.
By increasing the osmolarity of the airway surface liquid, water moves towards the lumen of the airway. This movement of water and the increased mucociliary clearance induced by hyperosmolarity also stimulates sputum production. The problem associated with this treatment is similar to the problem associated with the hyperosmolar saline challenge for the determination of airway narrowing. An expensive nebuliser is required to carry out the procedure.
The present invention consists in a method for attempting to provoke airway narrowing in a subject comprising the steps of (a) causing the subject to inhale into the airways an effective amount of a substance capable of altering the osmolarity of airway surface liquid in the subject, which substance is in the form of a dispersible dry powder containing an effective proportion of particles of a respirable size, and (b) measuring in the subject a parameter indicative of the resistance to air flow of the subject's airways.
In another aspect the present invention consists in a method for inducing sputum comprising the step of causing a subject to inhale into his or her airways an effective amount of a substance capable of altering the osmolarity of airway surface liquid, the substance being in the form of a dispersible dry powder containing an effective proportion of particles of a respirable size.
In a still further aspect the present invention consists in a rupturable container containing an effective quantity of a substance capable of altering the osmolarity of airway surface liquid in a subject, the substance being in the form of a dispersible dry powder containing an effective proportion of particles of a respirable size.
The administration of a hyperosomolar challenge to a subject in the form of a dry powder rather than a wet aerosol enables the challenge to be administered through a conventional dry powder inhaler rather than through a nebuliser. This is highly advantageous as these inhalers are very cheap and are widely available. The time to perform a challenge is halved as there is no cleaning, sterilising, maintenance or weighing involved in the use of the dry powder test. It would also appear that smaller doses of challenge substance need to be administered in the dry state to achieve a desired response than was required with that substance in the form of a wet aerosol.
As used in this specification, the term "airways" includes both the upper airways of the nose and the lower airways of the lungs. While the invention is particularly applicable in the latter case it is also applicable in the former case for the detection of actual or incipient rhinitis, which may be due to dry air or allergens, and similar conditions. While the invention is hereinafter described with particular reference to the lower airways, this teaching could be applied with equal effect to the airways of the nose.
The substance to be inhaled may be any substance that is biologically compatible with the subject and is capable of altering, normally increasing, the osmolarity of the airway surface liquid of the subject. Preferably the substance is a mineral salt or a sugar or sugar alcohol, more preferably it is selected from the group comprising salts of sodium or potassium, hexose and pentose sugars and their corresponding sugar alcohols. It is most preferred that the substance is selected from the group comprising sodium chloride, potassium chloride, mannitol and dextrose. Of the more preferred groups of substances sodium chloride and mannitol are the most preferred for their cheapness, their availability in the required particle size and their biological compatibility.
The substance is required to be inhaled into the airways, usually the first 8-12 generations, and an effective quantity is required to deposit on the surface of the airways. Preferably the substance will make contact with the airways surface in the first twelve generations of the airways. For this to happen it is necessary for the inhaled substance to be present initially in a sufficient quantity, for it to be sufficiently dispersible that it can be entrained by the subject's inhaled breath or by a propellant gas, and a sufficient proportion must be of a respirable particle size. The term "respirable particle size" is taken to mean a size that is sufficiently small that the particle will not settle out or impact against the subject's throat rather than be drawn into the airways of the subject's lungs. In practice it has been found that particles of less than about seven microns are respirable.
In the case in which it is desired to induce airway narrowing, such as for testing for asthma, it may be desirable that as much of the powder is of a respirable size as is possible to reduce impaction on the oropharynx. In this case particles in the respirable range preferably comprise at least 10% of the substance by weight, more preferably at least 25%, even more preferably at least 40% and most preferably at least 50%. By contrast in the case where it is desired to induce sputum it may be desirable to include both respirable particles and non-respirable particles as the latter may induce coughing which will itself assist in the production of sputum. The desired dose in either case will depend upon individual circumstances and will be selected by the supervising health care personnel.
The method for attempting to provoke narrowing may be used for testing subjects for their susceptibility to asthma. In this case the subject may be administered a series of challenges each of a higher dose of the selected substance. After each challenge the subject will be tested for airway narrowing, usually by measuring the forced expiratory volume in 1 second (FEV1). Other known methods for measuring parameters indicative of airway narrowing could equally well be used and airway resistance is usually used for the nose. It will be appreciated that in many cases there will be no narrowing which is indicative of a negative propensity for asthma or rhinitis. In the case of subjects susceptible to asthma there will be a narrowing of the airways proportional to the sensitivity of the subject to the effective administered dose of the substance, that is the dose actually reaching the airway surface. In each case the parameter indicative of resistance to airflow after challenge is compared with the same parameter measured before the challenge to indicate the presence or absence of airway narrowing.
The substance is preferably packaged in a rupturable hard capsule, e.g. gelatin. The capsules preferably contain doses of from 1 to 100 mg, preferably 5 to 40 mg in the case of challenge testing for asthma or rhinitis. In the case of sputum induction and mucocilliary clearance, higher doses may prove desirable in subjects where airway narrowing is not a concern. In the case where it is desired to induce sputum from asthmatics or increase mucociliary clearance it may be necessary to premedicate the subject with a beta adrenoreceptor agonist, Intal or Nedocromil sodium before treatment to prevent the airways narrowing.
The present method for the induction of sputum may be used not only to collect sputum for analysis for the presence of viral or microbial pathogens but also in asthmatics to harvest inflammatory cells from the lung. This allows the state of activation of these inflammatory cells to be determined without invasive harvesting of the cells from the subject.
FIG. 1 is a graph showing the percentage of predicted FEV1 for healthy and asthmatic subjects before and after a dry powder challenge according to the present invention;
FIG. 2 is a graph showing the dose of dry powder relative to the dose of wet aerosol required to cause an asthmatic response in susceptible subjects;
FIG. 3 is a graph showing nasal airflow resistance before and after a dry powder challenge according to the present invention; and
FIG. 4 is a graph showing nasal airflow resistance before and after two successive dry powder challenges according to the present invention.
To establish the efficacy of using a capsule system to deliver sodium chloride or mannitol particles for inducing airway narrowing in patients being treated for asthma.
Asthmatics born between Jun30, 1951 and Aug19, 1975 aged between 19-55 years were recruited from the local community. All were clinically recognised asthmatics and were being treated for this disease. All subjects were non-smokers, had a baseline forced expiratory volume in one second (FEV1) greater than 50% and a provocation dose of 4.5% saline to cause a 20% fall in FEV1 (PD20)<30 ml.
The protocol for the 4.5% saline challenge was that described by Rodwell et al 1992, (American Review of Respiratory Disease, 1992; 146:1149-55). Subjects were excluded from the study if they had a chest infection in the previous six weeks. Subjects could not take bronchodilators for six hours before the lab visit, no corticosteroids were taken on the day of the study and no anti-histamines for three-five days before the study day.
This study was approved by the Royal Prince Alfred Hospital Ethics Committee and all subjects were required to sign a consent form prior to commencing the study. The study was performed under the Clinical Trial Notification Scheme (CTN No 94-492,94-633) of the Therapeutics Goods Administration of the Commonwealth Department of Health of Australia.
On the first visit to the laboratory each subject performed a standard hyperosmolar saline challenge with 4.5% saline delivered by an ultrasonic nebuliser. They were included in the study if they had a 20% reduction in FEV1 provoked by this challenge. An asthmatic response is considered to be a reduction in FEV1 greater than 15% from the pre-challenge value. They returned to the laboratory on 2 to 5 occasions. A minimum period of 48 hours separated each visit. On at least one of these occasions they inhaled an encapsulated dry powder of either sodium chloride or mannitol. Seventeen subjects performed the challenge with sodium chloride using a Halermatic(Fisons Pharmaceuticals)(Experiment 1), thirteen subjects performed a challenge with mannitol (Experiment 2) and 10 of these same subjects also performed a challenge with dry sodium chloride (Experiment 3) using a Ingelheim Inhalator (Boehringer Ingelheim).
Dry powder of sodium chloride or mannitol were prepared by spray drying an aqueous solution and milling, if necessary, so that particle size was in the respirable range (<7 microns). The powder was produced by Genentech Inc, South San Francisco, Calif. and sent in vials of 400 or 600 mg to our laboratory. There were two batches of sodium chloride and one of mannitol. Gravimetrically determined (change from known, known may be preferable) amounts (5, 10, 20 and 40 mg) of the dried powder were packaged in hard gelatin capsules (Gallipot, St Paul, Minn. 55120) by our laboratory staff. In order to reduce any possibility of re-hydration, this was carried out under controlled air conditions (temperature 16�-20� C. relative humidity 40%).
Either the Halermatic or Ingelheim Inhalator was loaded with a capsule containing either 5, 10, 20, or 40 mg of sodium chloride or mannitol. The capsule was broken and the subject inhaled either once or twice to empty the capsule.
The inspiratory flow rate through the Halermatic was measured indirectly by measuring the change in pressure at the mouth (Viggo-Spectromed DTX Disposable Pressure Transducer, Oxnard, Calif., USA) during a maximal forced inspiration and values between 29-188 L/min were recorded (Miniwriter Type WTR771A, Watanabe Instruments Corp). The low flow rates are due to the resistance of the device. For the Ingelheim Inhalator the inspiratory flow rate was measured by attaching it to a Minato Autospirometer (AS 800, Osaka, Japan) with the subject being asked to perform a maximum inspiratory manoeuvre through an empty Ingelheim Inhalator at the beginning of each study day. The Minato AS 800 was calibrated using a rotameter and variable flow.
The FEV1 was measured (Minato Autospirometer AS300, Minato Medical Science Co Ltd, Osaka, Japan) in duplicate, 60 seconds after the administration of the capsule.
The highest value was taken to calculate the airway response.
The reduction in FEV1 for each dose was expressed as a percentage of the value for FEV1 measured 60 seconds after an inhalation manoeuvre had been made from the inhaler containing an empty capsule.
The challenge was started by giving an empty capsule. The dose was started at 5 mg and was doubled with each exposure to a cumulative dose of 635 mg (5, 10, 20, 40, 2�40, 4�40, 4�40, 4�40 mg). This protocol for dosing was varied by repeating the same dose if the subject had a `significant` reduction in FEV1.
The subjects performed spirometry for at least 30 minutes following the completion of each challenge to assess spontaneous recovery.
The airway response has been expressed in terms of the dose delivered that was required to provoke a 20% reduction in FEV1 (PD20). A value for a 15% fall in FEV1 could equally have been used (PD15). These values were obtained by linear interpolation from a graph relating % fall in FEV1 to the dose of sodium chloride or mannitol delivered.
The particle size was measured on a multistage liquid impinger (Astra Pharmaceuticals). This device measures particles in the range of 13-6.8 mm, 6.8-3.1 mm and <3.1 mm. This device was used to measure the dose of sodium chloride that was in the respirable range (<6.8 mm). To do this 25 ml of sodium chloride or mannitol of known osmolarity was placed in each of the 3 stages of the impinger. Three 40 mg capsules of sodium chloride or mannitol were placed in either the Halermatic or an Inhalator and the powder was drawn, by a vacuum pump, through the impinger via a `throat` at 60 L/min. The osmolarity of the fluid in the 3 stages was measured. The results of this showed that for the sodium chloride delivered by the Halermatic approximately 30% was within the respirable range. For the mannitol via the Ingelheim Inhalator it was 22% and for the sodium chloride via the Inhalator it was 16%.
The geometric mean and 95% confidence intervals have been calculated for the PD20 for the wet aerosol challenge with 4.5% saline and the dry powder challenge with sodium chloride and mannitol. A paired t-test was carried out after log transformation of the values. Pre-challenge lung function (FEV1) was also compared using a paired t-test. The relationship between the PD20 to dry mannitol and sodium chloride and wet 4.5% saline was determined using a Piersons correlation coefficient. A value of p<0.05 was taken as significant.
Reference values
For spirometry were taken from either Goldman & Becklake (Am Rev Respir Dis 1956;79:457-467) or for the studies with the Ingelheim Inhalator from Quanjer et al (Eur Resp J 1993; 6(Supp 16)5-40). Reference values for normal responses to 4.5% saline are taken from Smith & Anderson (Eur Respir J 1990; 3:144-151). The upper limit of the fall in FEV1 in healthy control subjects is 12%.
Asthmatic subjects
The results are presented in the three accompanying tables and illustrated in FIGS. 1 & 2 for all tests. The asthmatic medication currently being used by the subjects, the FEV1 as a percentage of the predicted value on the initial visit (control day), the PD20 values for the challenge with the wet aerosol of 4.5% saline, the dry powder of mannitol or sodium chloride are given in Tables 1-3 for all subjects. For many subjects a second challenge was performed with the dry powder to demonstrate reproducibility of the airway response. For one study some of the subjects also performed a challenge test using methacholine and the PD20 values for these subjects are also given in Table 2. There was no significant difference between the pre-challenge values for FEV1 on each study day or the PD20 provoked by the capsule on two test days for any of the experiments.
FIG. 1 illustrates, for each test, the pre and end challenge values for FEV1 expressed as a percentage of the predicted normal value. This demonstrates clearly that the airway response to the dry powder challenge was different between the healthy control subjects and the asthmatic subjects and that the airways of the asthmatic subjects narrowed in response to inhaling the dry powders (in all but one case). FIG. 2 illustrates the PD20 to the dry powders of sodium chloride and mannitol in relation to the wet aerosol of 4.5% saline. This demonstrates that the subjects were somewhat more sensitive to the inhalation of the dry powders of sodium chloride and mannitol, compared with the wet aerosol of 4.5% saline delivered in a similar dose. This was particularly evident in Experiment 1 where there was a significantly lower dose of dry powder sodium chloride required to produce a 20% fall in FEV1 compared with the wet aerosol (p<0.02).
TABLE 1__________________________________________________________________________ EXPERIMENT 1DRY POWDER SODIUM CHLORIDE VIA HALERMATIC Steroids % Pred FEV1 4.5% Saline NaCl#1 NaCl#2Subject Dose Duration Pre chall PD20 PD20 PD20No Medications (ug/day) (mth) Control Day (mg) (mg) (mg)__________________________________________________________________________ 1 Fenoterol 96.8 651.2 146 127 2 Salbutamol BUD 800 3 94.2 149.4 161 96 3 Salbutamol 119.7 295.2 155 162 4 Salbutamol 88.1 249.8 121 118 5 Salbutamol 110.3 508.5 423 588 6 Salbutamol 75.7 232.7 126 105 7 Salbutamol 106.2 153.0 20.45 75.69 8 Salbutamol 103.3 166.5 106 52 9 Salbutamol 80.1 79.7 29 4010 Terbutaline BUD 1200 24 146.6 913.5 493.5 502.911 Salbutamol 86.4 725.4 36.1 79.512 Salbutamol BEC 500 4 122.4 515.3 340.7 268.613 Terbutaline prn BUD 800 6 81.5 205.7 257.99 128.814 Salbutamol BEC 1000 48 66.2 58.5 87.93 132.0315 Salbutamol BUD 2000 23 76.3 16.7 19.4 62.916 Salbutamol 88.2 254.3 630 283.117 Salbutamol BEC 400 48 79.6 137.7 52.6 19.16 Mean 95.4 Geomean 215.23 116.3 116.8 SD 20.6 95% CI 128.3,361.2! 66.53,203.4! 74.6,183.1! n = 17 n = 17 n = 17 p = 0.02 NS n = 17 n = 17__________________________________________________________________________
TABLE 2__________________________________________________________________________EXPERIMENT 2 □ DRY POWDER MANNITOL VIA INGELHEIM INHALATOR Steroids % Pred FEV1 4.5% Saline Mannitol #1 Mannitol #2 MecholylSubj Dose Duration Pre chall PD20 PD20 PD20 PD20No. Medications (ug/day) (mth) Control day (mg) (mg) (mg) (umol)__________________________________________________________________________ 1 Salbutamol 100 296.1 92 102 3.12 2 Salbutamol BECL 400 72 102 32.85 61.7 43.1 0.27 3 Fenoterol BECL 1000 60 65.7 7.2 20.5 53 0.22 4 Salbutamol BUD 1600 24 65.5 163.35 131.2 183.2 1.04 5 Salbutamol BECL 100 PRN 92.6 955.8 112.2 96.9 0.79 6 Salbutamol BUD 2400 6 67.4 99.9 225 7 Salbutamol BEC 800 8 61.2 38.7 11.6 6.2 8 Terbutaline BUD 1200 36 129 916.65 366 463.1 2.71 9 Salbutamol BUD 800 6 85.1 45.9 42.3 84.2 0.2110 Salbutamol BUD 800 24 87.1 378 295 337.1 1.7711 Terb,Theo BUD 6400 15 53.8 378 >635 >63512 Salbutamol 71.6 130.05 76 24.513 Salbutamol BEC 500 PRN 116 229.95 77.514 Salbutamol 67.2 363.15 113.9 Mean 83.16 Geomean 149.4 85.84 77.99 SD 22.4 CI 67.7,329.8! 47.8,156.9! 31.57,192.67! n = 14 n = 13 n = 10 NS NS n = 13 n = 10__________________________________________________________________________
TABLE 3__________________________________________________________________________EXPERIMENT 3DRY POWDER SODIUM CHLORIDE VIA INGELHEIM INHALATOR Steroids % Pred FEV1 4.5% Saline NaCl#1 NaCl#2Subject Dose Duration Pre chall PD20 PD20 PD20No Medications (ug/day) (mth) Control Day (mg) (mg) (mg)__________________________________________________________________________ 1 Salbutamol 100 296.1 73.7 172.1 2 Salbutamol BECL 400 72 102 32.85 22.1 151 3 Fenoterol BECL 1000 60 65.7 7.2 50.1 18.2 4 Salbutamol BUD 1600 24 65.5 163.35 67.2 151 5 Salbutamol BECL 100 PRN 92.6 955.8 107.7 103.8 6 Salbutamol BUD 2400 6 67.4 99.9 168.2 138.22 7 Terbutaline BUD 1200 36 129 916.65 407.2 8 Salbutamol BUD 800 6 85.1 45.9 105.6 55.08 9 Salbutamol BUD 800 24 87.1 378 151.5 56.3910 Terb, Theo BUD 6400 15 53.8 378 >635 >635 Mean 84.82 Geomean 152 95.3 86.67 SD 22.5 95% CI 49.7,464.7! 50.6,179.43! 50.6,183.6! n = 10 n = 9 n = 8 NS NS n = 9 n = 8 Mean p = 0.096 p = 0.69__________________________________________________________________________
Experiment No 3 dry sodium chloride through Inhalator
The mean �SD value for FEV1 expressed as a percentage of the pre-challenge pre-capsule value was 88.4%�10.6%, 30 minutes after challenge and 94.8%�7%, 60 mins after challenge.
TIME & NUMBER OF CAPSULES TAKEN for DRY CAPSULE CHALLENGE
For Experiment No 2
The mean time taken to perform the challenge with the dry capsule of mannitol was 10.0�3 min and varied from 6-14 minutes for the 13 subjects.
For Experiment No 3
The mean (�SD) time taken to perform the challenge with the dry capsule of sodium chloride was 10.6�3 min and varied from 6-15 minutes except in Subject 10 where it was 20 min. The mean number of capsules was 8.6�6.7 for subjects Nos 1-9. Subject 10 required 33 minutes but failed to respond. He was taking 6400 μg of Budesonide daily.
Inspiratory Flow Rates through the Halermatic
The inspiratory flow rates in all but a few inhalations exceeded 50 L/min. The flows became lower as the dose of powder in the capsule increased. Thus when the empty capsule was in the Halermatic the median flow was 96 L/min and when the 40 mg capsules were inhaled it was 73 L/min.
Inspiratory Flow rates through the Inhalator
These were only measured once on each day of study. In all subjects the flow rate exceeded 43 L/min and the range was 43-70 L/min median value was 57 L/min.
Oxygen Saturation during challenge
An Ohmeda Biox pulse oximeter (3700e Louisville, Colo. USA) was used to measure arterial oxygen saturation. This was performed as an index of safety to ensure that severe hypoxemia did not occur during the inhalation of mannitol. Only three subjects had a reduction in saturation of greater than 3% and all values for saturation remained within the normal range throughout the challenges with dry powders.
Healthy Control Subjects
Five healthy control subjects (aged 19-22 yr) were studied, four received a dose of 620 mg and one 540 mg. None of these healthy volunteers, who acted as control subjects, recorded a PD20 and the maximum % fall in FEV1 was 6.5% with the range being 0-6.5%.
The results of this study clearly demonstrate that both sodium chloride and mannitol, delivered from a capsule via either a Halermatic or Inhalator device, can provoke airway narrowing in the same asthmatic subjects who are sensitive to the wet aerosol preparation of saline. There was a good range in the severity of the hyperresponsiveness of asthma as demonstrated by the PD20 to the wet aerosol. There were no adverse experiences requiring medical intervention. The mannitol powder was extremely well tolerated. Some subjects found difficulty in inhaling the powder of sodium chloride, particularly in the 40 mg dose. We estimated that less than 30% of the dose deposited in the lower respiratory tract while the remainder impacted on the device and the throat. Ideally a greater percentage of the dose would have a particle size in the respirable range.
The advantages of the dry powder challenge over the wet aerosol challenge include; the faster time for challenge, the reduced necessity to clean apparatus and the potentially disposable nature of the inhalers.
This is the first ever report of the effect of inhalation of a dry powder of mannitol in human airways. This is the first report of the airway narrowing effects of dry particles of sodium chloride in known asthmatic subjects.
The only reference to inhalation of particles of sodium chloride in the respirable range is as a treatment for children suffering from bronchial asthma. Tikhomirov, Povlotska,& Zmievskaya (CC Number SU 1581325, Kind A Date 900730 Week 9113 (Basic) from the Soviet Union have reported that a course of 10-15 daily inhalations of a NaCl aerosol (containing 70-80% of 3 micron particles with a density of 9-12 mg/cubic meter) given in a chamber with air velocity of 0.1-0.2 m/sec, 40-60 vol % of relative humidity at 16-18 degrees for periods gradually increasing from 6-15 min would increase remission of asthma of up to 1 year in 61.5% of cases. The concentration of dry powder particles in our application is much higher, being typically between 2.5-10 mg/liter (250-1620 mg/cubic meter), and the application for our study is acute airway narrowing for diagnostic purposes not treatment.
This study was performed on a single subject. The subject was familiar with the methods and could perform reproducible results. The subject voluntarily activated his alar nasae muscles to prevent nasal airway narrowing on inspiration, and breathed at normal tidal volume and rate with peak inspiratory flow of at least 0.5 L/sec. The studies were performed in a seated position in an air conditioned room with ambient temperature controlled between 21.5� and 23.5� C. and relative humidity between 55 and 65%.
Transnasal pressure and flow were measured by posterior rhinomanometry. Flow was measured using a modified Sullivan mask (Rescare, Australia) attached to a No.2 Fleish pneumotachygraph. A firm air filled catheter was placed on the posterior tongue and sealed with the lips. This was referenced to the mask pressure and changes were measured with a Validyne MP45 pressure transducer (Validyne Corp, Northbridge, Calif.). Pressure and flow signals were recorded at a rate of 12 Hertz and were plotted simultaneously on a computer screen.
The pressure/flow data from a sample of between 5 and 7 breaths was recorded. Rohrer's equation (pressure drop=k1 *flow+k2 *flow2) was fitted to the data by least squares multiple linear regression. The nominal nasal resistance was then calculated from the fitted pressure drop at a flow rate of 0.5 L/sec in the inspiratory direction. Baseline nasal resistance was the average of at least 4 measurements. Once the baseline was established subjects underwent the challenge protocol and nasal resistance was measured at 1, 2, 4, 6, 8, 10, 15, and 20 minutes after the challenge.
The salt was delivered to the nasal mucosa using a Spinhaler device (Fisons Pharmaceuticals)loaded with half the total dose. The subject placed the loaded Spinhaler just inside one nostril and inhaled deeply. If the salt capsule was not empty after one inhalation, the subject performed another until the capsule was completely empty. The device was then reloaded and the other nostril was used.
The FIGS. 3 & 4 show nasal resistance over 4 baseline measurements before challenge, followed by measurements made after the challenge. Nasal resistance is expressed as cm H2 O/L/sec. Both illustrate an increase in nasal resistance at 1 minute with a gradual fall to baseline over 15 minutes. This pattern is very similar to that seen with cold dry air both in terms of the degree of increase and the pattern of the subsequent fall to baseline. FIG. 4 shows results following inhalation of 40 mg, measurements for 20 minutes then a repeat dose of 40 mg.
Method for measuring mucociliary clearance Mucociliary clearance is assessed using a radioaerosol technique (99 mTc-sulphur colloid is commonly used). The radioaerosol should be generated with a nebuliser that produces droplets that have a mass median aerodynamic diameter (MMAD) of about 6 mm and a geometric standard deviation (GSD) under 2. A monodisperse aerosol would be ideal. The radioaerosol should be delivered with a controlled breathing pattern to achieve deposition in the large airways or the conducting airways. This is best achieved by having a target, on a computer or an oscilloscope screen, that sets the tidal volume and the inspiratory and expiratory times. Experimental data have shown that a tidal volume of 450 ml and a peak inspiratory flow rate of about 60 L/min is a good breathing pattern for central deposition. The activity delivered in the lungs should be about 40 MBq, so the delivery time should be adjusted accordingly. Usually 2 to 3 minutes is sufficient if the starting activity in the nebuliser is about 1 GBq.
Measurement of mucociliary clearance should start as soon as possible after the delivery of the radioaerosol. The best way to assess mucociliary clearance is using a gamma camera. Collection of emission images with a gamma camera gives good information about the initial deposition of radioaerosol in terms of distribution and intensity. Serial anterior/posterior images for about one hour provide the best data for assessing mucociliary clearance. A big advantage is that a regional analysis can be achieved for assessing mucociliary clearance of the large and small airways. Mucociliary clearance follows, usually, a bi-exponential pattern and curve fitting is commonly used to smooth the data. The salt or mannitol is administered after the collection of the first images that are used to assess the initial deposition of the radioaerosol.
Dry powders of substances that have the potential to increase the osmolarity of the airway surface liquid, when inhaled in an adequate dose containing an adequate amount of respirable particles are suitable for use in bronchial provocation testing to identify persons with airway hyperresponsiveness consistent with asthma. These same substances can also be inhaled into the nose to identify persons with rhinitis. These same substances have the potential to be used to induce sputum and increase mucociliary clearance.
Patent Citations
Non-Patent Citations
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Lori Erskine: April Employee of the Month
The April Employee of the Month was awarded to Lori Erskine,
CMA, ROT, of Pen Bay Orthopaedics.
"Lori does an exceptional job, she is always willing to go
that extra mile and she does it with a smile on her face. Always willing to
stay late and make that extra effort to make sure the patients have an
excellent outcome."
From a patient: "I wanted to let you know how much I
appreciated Lori's patience and her kindness. It made all the difference in the
"Lori is motivated to better herself and the practice .She
initiated and went to a casting course and is now a Registered Orthopaedic
Technologist. This means she is the only clinical staff member, other than
providers, that can apply casts to patients. This helps out work flow and frees
up providers.
Alisa Munn: March Employee of the Month
The March Employee of the Month was awarded to Alisa Munn, Certified Nurse's Aid in the Surgical Care Center
"Alisa has a warm, welcoming way about her that sets her
patients at ease. She manages to stay one step ahead of the needs of the day
and keeps everything running smoothly. She comes in on her day off, is often
training new staff with great patience, and maintains a calm affect even when
the demands of the day may be more than most people could handle."
"Alisa is also very
devoted to her family. As a mother of 4 children, Alisa is constantly baking
for a school function, hosting a celebration for her grandchildren at her home,
or running her youngest child to wrestling practice. She does all this with
positive, can-do attitude and a smile on her face."
Shannon Wilson: Manager of the 1st Quarter, 2015
"(Shannon) is always willing to help or find a solution to
the problem. She is always so kind and pleasant that she sets the bar. She holds
her head high and carries on with her work. To me she is a power of example of
how I want to be! Kuddos!"
"She is caring, kind, professional, understanding,
respectful and overall a great person who I enjoy having as a manger."
"Shannon is a exceptional manager! Her door is ALWAYS open
for any of us to go in at any time…she drops what she is doing to listen and
offer advice and guidance. She always goes above and beyond for her department
and her employees. She is a beautiful person inside and out."
The Daisy Award of the 1st Quarter was awarded to
Nora Metcalf, RN Pen Bay OB/GYN
Nominated by a co-worker "When things get stressful around a possible
resuscitation of a baby, she is the one nurse I want available to help. On 2/15/15, we had a mom come in active
labor, an hour and a half later, the baby was born needing resuscitation. Because of this nurse's anticipatory assistance,
we had everything and everyone ready and things went smoothly. Even the Pediatrician commented that it made
his job so much easier with this nurse there, anticipating that what he needed
and having it ready."
1st Quarter nominees were April Totman, RN (SCU), Butch Allen, RN (Med/Surge), Kelly Jackson, RN (PARC), Darci Linscott, RN (Med/Surge) Michelle Smith, RN (Med/Surge), and Terri Lemieux, RN.
Seated Left to Right:
Madelyn Drinkwater, Charlotte Root, Louise Kinney, Debbie
Carson, Noreen Mellor, Sarah Thompson, Jane Staman, Eunice Stadler and A.
Jeanette Achorn.
Standing (left to right):
Suzanne Armstrong,
Kathy Bernier, Mike Conte, Roz Dillabough, Carol Robinson, Barbara Widdecombe,
Kathy Beck, Virginia Johns, Polly Grover, Karen Wincapaw, Karli DeHart, Jane
Piper, Dayle Goulding, Morris Dorenfeld, Nathan Perkins, Bette Hilton, Charlie
Merrill, Margaret Simmons, Dennis Haines, Nancie Burton and Pen Bay Medical
Center Volunteer Director, Judi Trenholm
Pen Bay Healthcare is a community health care system dedicated to caring for the sick and injured and to improving the health and quality of life of the people of mid-coast Maine.
Limited space available for this employee training.
Training will cover:-Functional Formatting -Basic Formulas & FunctionsWho should attend?
-Validating Data -Graphing & Charting
-Importing Data -Conditional Formatting
-"If" Statements -Vlookup Command
-Pivot Tables
-Anyone who wants to learn more about using Excel
-Anyone who knows some basics of Excel but wants to know more
-Managers or Supervisors who would like more information about how to make Excel work for them
For additional inquiries or to reserve your spot, please call x8210


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This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
Other areas nearby to Santa Cruz:
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Recent Santa Cruz reviews
"This house completely meets the description provided: spacious, well-furnished, stocked with amenities, comfortable, great views, and conveniently located. We were very pleased with our stay and would like to return again for another special occasion. Our 3 1/2 year old granddaughter was so excited by the bunk beds and assortment of toys that she squealed with joy while hopping up and down upon our arrival."Guest: Cantaur Date of Stay: April 2015 Review Submitted: April 20, 2015View listing
"The owners' couldn't be any nicer -- very accommodating! I needed to reach him just hours before our check-in time and he was easy to contact. Also, one of my guest accidentally took one of the parking permits home. The owner was very nice about arrangements for returning it and was not upset. The house was the cutest! Plenty of space to sleep 6 comfortably. Also, definitely enough space in the house for 12 to bbq and to play board games during the day. We had a blast! Sincere thanks for sharing their home! I will definitely be back -- next time for more than one night!"Guest: Janey Date of Stay: June 2015 Review Submitted: June 12, 2015View listing
"This historic cute bungalow is located a walk from the beach and a very nice part of town. My wife myself in our three kids stayed here for four days and loved it. The house has everything you need to stay at night you can hear the waves break in the bay. It's an easy walk to most everything you need to go to. We definitely plan i'm staying at this location again."Guest: Kenneth G. Date of Stay: March 2015 Review Submitted: March 26, 2015View listing
"My wife and I spent two months here from Feb. to April 2015. We found the place to be quiet, restful, spacious and full of light. The neighbourhood was also quiet, pleasant and safe. The weather was great for us, sunny, warm, without humidity and bugs. Convenient to many things in Santa Cruz without necessarily needing a car. We'll return."Guest: alan m. Date of Stay: February 2015 Review Submitted: April 26, 2015View listing
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text:
Original recipe yields 12 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Great recipe! Everyone loved it and it was super easy to make. I think next time I'll use less whipped topping though, it overpowered the cream cheese taste, IMHO.
This recipes is very good and very easy . It always gets rave reviews. The cheesecake layer is a little light so I usually call it strawberry cheese pie instead of cheesecake. I usually use s...
This is just what I was looking for-a fluffy, creamy cheesecake. I did use 6oz of whipped topping instead of the whole container. Everyone loved it!


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Baseball, Biglaw, Books, Non-Sequiturs
* If anything, baseball stadiums need less netting to prevent fans from catching foul balls. And if your six-year-old gets clocked in the head by a batted ball, it should be a lesson to wealthy fans in great seats to pay attention to the goddamn national pastime instead talking on your cell phone or watching the scoreboard or doing whatever non-baseball activity that distracted you from the 2-2 count with the lefty up at bat. [Legal Blog Watch]
* Pop quiz, law professors. What do you do? [Volokh Conspiracy]
* Here's a great review of Mark Hermann's book: Inside Straight, that focuses on Hermann's use of the commenters in his material. This will provide excellent research for my own project: How I Became An Affirmative Action Walrus. [Simple Justice]
* Don't you love how the Michigan Law walk-out on Rob Portman is now actually a bit of a thing in the VEEPstakes? [Gawker]
* It's been a while since I studied commercial paper, but I'm pretty sure SpongeBob Squarepants coins aren't going to pass muster. [Dealbreaker]
* Ohio tries to further regulate fracking, but efforts to frustrate fracking f**k-ups feel futile. [Fulbright Fracking Blog]
* Morrison & Foerster elects new firm leadership. [Thomson Reuters News & Insight]
Health Care / Medicine, Quote of the Day, Sex
Quote of the Day: Talk About a Poison Pill…
With a myriad of laws being proposed to regulate women's reproductive health, female lawmakers are using sarcasm in an effort to regulate men's reproductive health….
Kinney's Evan Jowers Now Permanently Based In Hong Kong
After a decade of 60+ trips to Hong Kong from his former Miami home, our Evan Jowers has finally taken the plunge and moved to Hong Kong on a permanent basis. Since '06, Evan has been head of Kinney's Asia recruiting and over that time Kinney has easily placed more US associates, counsels and partners at top tier US and UK firms than any other recruiting firm (we have also made many in-house placements). (…)
5th Circuit, Ann Althouse, Barack Obama, Books, Clerkships, Depositions, Drinking, Drugs, Fat People, Gay, Lesbians, Nauseating Things, Non-Sequiturs, Politics
* Pepsi lawyers offer a creative (if disturbing) defense to a lawsuit by a man who claims he found a mouse in his Mountain Dew. [Madison County Record via The Atlantic Wire] * Will birther queen Orly Taitz get to depose — i.e., "rupture the jurisprudential hymen" — of President Barack Obama? That would be […]
Biglaw, Music, Videos, Weirdness, YouTube
The Squire Sanders Attorney Who Made the 'Most Epically Awful' Video of 2011
We talk a lot here on Above the Law about the difficulties attorneys have in finding a work-life balance. Often Biglaw life becomes all work, all the time. Or sometimes, burned out attorneys run in the other direction entirely and open a bike shop, but it rarely feels like there is a viable in-between. I'm […]
Bad Ideas, Funny Headlines, Holy Crap, Lunacy, Nauseating Things, Pictures, Pranks, Romance and Dating, Rudeness
Love Hurts, Especially When Your Boyfriend Gives You a 'Tatt-poo'
As it turns out, the the crazy "poop tattoo" lawsuit story is full of crap. But it was fun while it lasted, no?
Football, Junk Email / Spam, Sports, Technology
Ohio Attorney Sues Over Misleading Emails, Even Though He Wasn't Misled
It's not like the general public needs more reasons to dislike attorneys, yet unfortunately, there's always more fuel for the fire. If you read the news, you might say they are boozers, they are arrogant, and they are tools. Now cynics can add "cherry-pickers" to that list. The attorney in the following case acted like […]
Constitutional Law, Free Speech, Law Schools, Minority Issues, Racism
Former 'Hate Group' Leader Chosen To Represent University of Toledo Students On Constitutional Panel
Last year, we wrote about Kyle Bristow, a student at the University of Toledo College of Law. Bristow had been the chairman of the Young Americans for Freedom student chapter at Michigan State University when he was in college. The MSU-YAF was designated a "hate group" by the Southern Poverty Law Center. Hey, we're living […]
Biglaw, California, Email Scandals, Facebook, Job Searches, Law School Deans, Law Schools, Money, Morning Docket, Pictures, Technology
* According to the Bureau of Labor Statistics, 100 new jobs were added to the legal industry last month. About 40,000 students graduated from law school this spring. You do the math. [Am Law Daily] * This Maryland law school dean thinks that the U.S. News rankings "generalize about things that are not generalizable." Come […]
DUI / DWI, Family Law, Lawyer Advertising, Small Law Firms, Solo Practitioners
Always Hire the Lawyer Who Can Break the Most Bricks
Every time we do a post about a crazy attorney website, our readers send in even more tips about the seemingly endless supply of wacky websites that are out there (which we appreciate, so keep 'em comin'). Rarely, however, do we get a tipster begging us to place a fellow attorney in Above the Law's crosshairs. Until now: "Can you please, please profile this guy, Mark Davis from Toledo, Ohio?" Well, since you asked so nicely….
Success Tips For New Associates
Succeeding as a new associate is a juggling act that will involve balancing your evolving legal expertise with managing your workload, creating relationships with partners, fellow associates and support staff at your firm, and building strong business relationships. Here are a few tips to help you thrive during this pivotal time in your legal career. […]
Cars, Rudeness, Stupid Lawyer Tricks
Law License Plates: Say It Loud, We're Lawyers and We're Proud
In this edition of the Law License Plates series, we are writing about legal professionals who are so proud of what they do that they've slapped their titles on their license plates. If this isn't an invitation to get rear-ended, then I don't know what is. These submissions come to us from New York, Ohio, and Tennessee, proving that stupid lawyer tricks know no bounds across state lines….
Cars, Crime, DUI / DWI, Rudeness, Texas
Law License Plates: Defenders Unite
In our last edition of the Law License Plates series, we wrote about Massholes. In this version, we're writing about a different kind of a-hole: criminal and DUI defense attorneys. It seems like defense attorneys are making straight cash, homey….
Cars, Lawsuit of the Day, Suicide
Lawsuit of the Day: Good Samaritans Sue Woman They Rescued
Before you've been through 1L Torts, this story is shocking. After you've been through 1Ls Torts, it's not that surprising. Two men saved a woman from the wreckage of a burning car, and now they're suing….
Crime, Prisons, State Judges, Technology, Trials, Videos
Video Arraignments Save Money and Make Judges Feel Safer
Maybe I'm just naive, but I find the concept of conducting any courtroom business via video enthralling but also a bit unnerving. It seems so inconsistent with the mythical and timeless ideals of the hallowed halls of justice, yadda yadda yadda. Whether we like it or not, however, video conferencing is creeping into courthouses across […]
Commencement, Evan Caminker, Gay, Gay Marriage, Law Schools, Politics
Dean Caminker Digs In To Support Anti-Gay-Marriage Commencement Speaker At Michigan Law
We told you yesterday that Michigan Law has decided to invite Sen. Rob Portman (R-OH) to speak to its 3L class for senior day. We told you that many Michigan Law students have objected to the choice of Senator Portman, because of his strong anti-gay rhetoric on the issue of gay marriage. We told you […]
Commencement, Evan Caminker, Gay, Gay Marriage, Law Schools, Politics
Michigan Law School Invites Ohio Senator With 'Anti-Gay Politics' To Speak At Senior Day
What's more strange about that headline? That Michigan Law would invite a guy who stands against the civil rights of certain members of the Michigan Law community, or that Michigan Law would invite a representative from Ohio to speak to its outgoing students? I'm going with the latter. Rob Portman graduated from the University of […]
Bar Exams, Law Schools, Legal Ethics, Student Loans
Character & Fitness Fail for Graduate With 'No Plan' To Pay Off His Debts
Wow. Guy goes to law school, guy racks up a huge amount of debt, guy has no idea how he'll pay off his debts. Sound familiar? Okay, here's the twist: the guy failed the "character and fitness" component of the Ohio bar because he has no plan to pay off his loans. What the hell […]
Cellphones, Constitutional Law, Drugs, Privacy, Technology
On Why It's Better To Be A Drug Dealer in Ohio Than in California
As a place to live, California has a lot going for it: the Pacific Ocean, pleasant weather, celeb spottings. But if you're concerned about the police perusing the contents of your smartphone without a warrant, you might prefer to spend your time further east, in the Buckeye State. The Supreme Courts of California and Ohio […]


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iad NubaNuba oomreakfast+wifiMorocco, Marrakesh-Tensift-El Haouz, Marrakesh
About This Listing
"Rockech a state of mind in Marrakech" is our life style, we have 3 hostel in the medina of Marrakech, very close to the Jemaa el Fna square.
we are ideally located close the markets and all major attractions.
Towels, bed sheets, soap, and toilet paper
Central heating or a heater in the listing
Continuous access in the listing
Breakfast is provided.
Space where guests can cook their own meals
Towels, bed sheets, soap, and toilet paper
Central heating or a heater in the listing
In the building, free or for a fee
In the building, free or for a fee
Continuous access in the listing
Breakfast is provided.
The listing can accommodate a gathering of 25 or more attendees
Easy access to the building and listing for guests in wheelchairs
Private or Shared
Free, in the building or nearby
Posted emergency information and resources
The Space
Riad Nuba
We offer a Room with private bathroom and 1 double room located at the ground floor.
We also have a beautiful terrace and a patio available for our guests.
Dinner and pasta nights are possible.
Wifi is free of charge for our travellers.
We can arrange excursion all over Morocco for our guests, and will assist you by booking your restaurants and your Hammams.
RocKech is the best place if you wish to know other travellers from all around the world, and if you are searching for a cheap but very nice hostel in Marrakech
Guest Access
Located only a few minutes far away from the main square, Rockech is also very easy to reach by car as we are located close the Ben Saleh parking.
You can reach us by bus nr 19 from the airport.
We also arrange taxi service
42 Reviews
Alberto & Co have been wonderful hosts ! Their riad Nuba Suite is absolutely beautiful and well situated, in the lively and popular neighborhood of the Medina of Marrakech. It makes your stay a unique and authentic experience. The cosy room was amazingly set up in an exquisite and quiet riyad with nice yard and terrace, all that for a very friendly price. The decoration is gorgeous: it makes you feel home. Alberto and his team have been extremely helpful in giving advices and contacts for visits in Marrakech, and elsewhere in Morocco. I definitely will stay again there for my next trip in Marrakech :) In few words, it was an amazing and charming experience.
E' stato bello trovare persone così disponibili, accoglienti e non invadenti.
Molto importanti le loro indicazioni per girare e vivere la città, dal momento che avevamo solo due giorni e mezzo a disposizione.
La suite Nuba è molto accogliente e pulita, posizionata in una zona ottima perché poco distante dalla vita della medina ma tranquilla e silenziosa.
Valore aggiunto la colazione e il relax in terrazza.
Riad consigliatissimo.
Tudo correu como planeado. Usámos o serviço de táxi do Riad e correu tudo lindamente. O Riad é muito central, muito bem localizado. O pequeno almoço no páteo é muito agradável.
Fantastic stay, the place was even more beautiful than expected. The hosts were extremely welcoming and explained to us how to get to the places we wanted to visit walking through Marrakech.
Lovely breakfast in the morning! My friend and I definitely recommend it!
Everything regarding communication and reception was excellent. Matteo was extremely friendly and also knowledgeable. Alberto walked me to my hostel (there are 3) and even tested me to make sure I had understood the way. I NEVER GOT LOST.
On the hostel itself: There are 3 hostels all owned by the friendly Italian triumvirate (matteo + alberto + simo). The main one is lovely, but unfortunately I did not stay there. My room was in a second one called Nuba, and I would say it felt a bit far away, while the main house is RIGHT in the main intersection of Medina. Nuba House is also new, and I felt like I was alone all the time, that exacerbated the feeling of being far away.
Nevertheless, everything about Nuba Hostel is IMPECCABLE. 100% clean, 100% good taste. The common rome is extremely lovely, I read there every night.
Breakfast: Extremely good, very friendly service.
Alberto Simone e Matteo sono stati molto accoglienti e disponibili per tutte le nostre richieste, la stanza è bellissima con bagno privato in camera e la colazione ottima! Anche gli spazi comuni sono molto belli, l'ideale per rilassarsi dopo una giornata nel centro di Marrakech.
As Tina Turner would say: "YOU are simply THE BEST!"...
LOVE THIS PLACE ! HIGHLY RECOMMENDED, thank you for everything!
This host has 399 reviews for other properties.View Other Reviews


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Amber Alert issued for 8-year-old Fresno girl
FRESNO, Calif. - FRESNO, Calif. (AP) - Authorities have issued an Amber Alert for an 8-year-old Fresno girl who was apparently abducted from her front yard while playing with a friend.
The California Highway Patrol says Elisa Cardenas was taken around 8:30 p.m. Monday.
CHP Sgt. Trent Cross tells KRON-TV the girl was taken by a stranger who managed to lure her to his vehicle.
She was last seen wearing blue jeans and a light purple Winnie the Pooh sweat shirt.
Fresno police say the suspect is described as a male around 6-feet tall and in his 20s with a shaved head. He was wearing a white tank top and blue jean shorts and driving an older model, reddish brown Ford two-door pickup truck. The vehicle had a 6-inch white stripe on it.
Information from: KRON-TV
Subscribe to the Ventura County Star
Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


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Delivery Man-35
for thematic elements, sexual content, some drug material, brief violence and language
- Release Date:
- 11/22/2013
- Genre:
- Comedy
- Runtime:
- 105 min.
- Director:
- Ken Scott
- Starring:
- Vince Vaughn, Chris Pratt, Cobie Smulders, Jack Reynor, Glenn Fleshler
This is the story of affable underachiever David Wozniak, whose mundane life is turned upside down when he finds out that he fathered 533 children through sperm donations he made twenty years earlier. In debt to the mob, rejected by his pregnant girlfriend, things couldn't look worse for David when he is hit with a lawsuit from 142 of the 533 twenty-somethings who want to know the identity of the donor. As David struggles to decide whether or not he should reveal his true identity, he embarks on a journey that leads him to discover not only his true self but the father he could become as well.


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In honor of National Picnic Month in July, we turned to LA food blogger Claire Thomas of The Kitchy Kitchen for her expert advice.
With the debut of "Endless Orchard," the produce-pushing art collective Fallen Fruit grows big, bigger, and into the record books.
All around LA, restaurants are seducing early-bird diners with ethereal drinks and chic little bites.
July 6, 2015
July 1, 2015
July 1, 2015
July 1, 2015


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$5.09They'd risk their lives for love--and they may have to.With a young daughter to raise and multi-million dollar hotel chain to run, the last thing Stephanie Mason wants is a relationship. But she's looking for a man--to keep her hotel safe. Enter Jack Kaufman. Ex-Navy Seal, former mercenary, and security specialist, not to mention dangerous and pulsing with raw sexuality, Jack is exactly what
$5.39Just because we have a past, doesn't mean we can't have a future. You think that because we've known each other forever, because we've been friends, we can't be lovers. You are absolutely wrong. You think that if you push me away, find me another woman, that I will give up the possibility of us. Wrong again. You think that what is between us can be ignored, but I think love always finds a way.
$5.39She's ready for something new. . .Hoping to start over after a painful divorce, Cassie Mancini moves to Texas and is ready to cut loose. When she attends her sister's bridal shower, she can't resist dancing with the sexy male stripper. There's just one problem. The man isn't a stripper. He's the groom's best man, Dr. Adam Hart, and he's a notorious player. Humiliated, Cassie plans to keep her
$4.99Azure Ellison may have undergone a total makeover, but she never expects to be romanced by Harper Hamilton, her former prep school friend. The ambitious journalist is after a career-making story about Harper's powerful Philadelphia family. But the charismatic attorney wants something from Azure in return: her vow to become his lawful wife in a marriage of convenience!Harper can't believe the girl
$4.99An heir to Southern California's most fabled vineyard, Donovan Drake works as hard as he plays. Betrayed by love in the past, the consummate bachelor prides himself on never committing to one woman. But Marissa Hayes isn't just any woman. And Donovan has just two weeks to show the guarded, voluptuous beauty exactly what she's been missing. Falling for her boss is number one on Marissa's list of
$4.99The youngest of five siblings, Marissa Hamilton is determined to prove herself in her family's powerhouse Philadelphia law firm. She has a close confidant in handsome and ambitious fellow attorney Griffin Jackson. But ever since the night they gave in to the passion smoldering between them, Marissa's world has been filled with lies, including one that could turn her whole life upside down.Griff
$4.99Alex Dovington is a man with a secret. The internationally famous jazz musician never learned to read. If the world-and his legions of fans-knew, it would be a disaster. When he learns Cara Williams has been hired to teach him, he is reluctant to follow the plan. The sultry teacher will be given only three days to teach the music legend everything she knows. But the instructor becomes the student
$4.99A little Southern comfort goes a long way To the world she's Vanessa Valentino, the poison-penned gossip columnist and blogger, but back in Georgia, she's just Tressie Valentine. After digging up one scandalous secret too many, she's forced back home to the sleepy town she thought she'd left behind forever. And now she must face Nathaniel Woodberry, who became her sworn enemy when one of her
$4.99When Kumi Walker found Veronica Hamlin stranded on a deserted road, he offered to fix her flat tire in exchange for a home-cooked meal. It wasn't long before the ex-marine realized that his attraction to the widowed Veronica was the real thing. But he was challenged to convince her that age was nothing but a number....Although Veronica had turned down countless numbers of Atlanta's most eligible
$4.99The baby of the family, Daniella Duvall has a passion for adventure in her blood. But the thrill-seeking travel writer gets more than she bargained for when the plane she's on spirals out of control in midair! The tall, dark stranger who comes to the rescue both intrigues and attracts her. When he disappears after their emergency landing, she's determined to find her vanished hero again.The man
$4.99He makes her feel like the most desirable woman in the world Sexy, magnetic Florida business owner and philanthropist Mikhail Coles is wrong for Cyanna Dupres in every way. And he's the one man who can give her what she wants. Seducing the commitment-wary bachelor is the easy part. But once Cyanna wants a lifetime connection, will she lose the lover who makes her feel like the world's most
$1.99When Sydney Harris' fiancé, Lance Edwards, develops cold feet and walks out of her life, ten days before their wedding day. She finds herself propositioning her former lover, Phoenix Sander.The moment she looks into Phoenix's smoldering sherry-chocolate eyes, she knows she's a goner. He is willing to marry Sydney, but only on his terms. Will Sydney give in to his ultimatum?


text: Finished my trip in Zanzibar at the Gold. We stayed three nights there. The hotel is new and perfectly located on the best beach on the island (no tides) I can't say more than "May N" (another member) who wrote an excellent complete review below which shows exactly what I think about the Gold Zanzibar. I couldn't say better.


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Caltrain's 'Freedom Train' Makes Its Last Voyage On Martin Luther King Jr. Day
After 30 years, the last of America's 'Freedom Trains' will take its final voyage down the rails on Monday.
4th Grader, His Nanny Narrowly Escape Burlingame Caltrain Crash After Car Gets Stuck On Tracks
A 4th grader and his nanny narrowly escaped injury when a Caltrain hit their car after it became stuck on the tracks in Burlingame.
Caltrain Strikes, Kills Person On Tracks Near Millbrae Station
A Caltrain struck and killed a person on the tracks south of the Millbrae station Saturday morning.
Caltrain's Switch From Diesel Fuel To Electrification Will Cause 'Significant' Backups For Drivers; Report Shows
Drivers on the Peninsula may soon be waiting even longer at some train crossings, according to a new report on Caltrain's switch to electrification.
New Year's Mass Transit Guide
If you choose to get hammered on New Year's Eve, rest assured you can get home safely for free via bus, train or light rail…
Palo Alto Community Pitches In For Holiday Gifts For 11 Guards Who Watch Dangerous Train Crossings
$350 gift cards were handed out this week to the 11 guards who keep watch at Palo Alto train tracks as part of the city's Track Watch program.
Caltrain 'Baby Bullet' Strikes, Kills Person On Tracks Between Mountain View And Sunnyvale
Caltrain service resumed but trains still experienced major delays hours after a northbound train struck and killed a person on the tracks between Mountain View and Sunnyvale on Friday evening.
Driver Survives After GPS Leads Him In Front Of Speeding Caltrain In Atherton
The driver of the Toyota Prius had mistakenly made a turn onto the tracks on the direction of his GPS unit.
Caltrain Delayed After Separate Crashes With 2 Vehicles
Caltrain is experiencing delays due to two separate incidents involving trains and cars this evening in Atherton and San Jose, Caltrain officials said.
Travel Guide From San Francisco For Thanksgiving's Seahawks Vs. 49ers Game
Refer to this travel guide when attending the San Francisco 49ers home game against the Seattle Seahawks on Thanksgiving.


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With a silhouette and materials inspired by a utilitarian piece, this interesting pair is elevated with artistic flair.


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The Noble Outfitters™ All Reins™ Glove combines a synthetic leather palm with a breathable stretch mesh back for a grippy glove that also offers good ventilation and fit. This riding glove has double-stitched critical seams and dual layers of SureGrip™ synthetic suede in key areas.
Ariat's Performer Mid-Rise Euro-Seat Breeches feature the V°3 waistband and Calf Fit System for comfort. Built-in core control provides tummy support and slenderizes the silhouette. Knee patches are made of durable synthetic suede.
The Ariat® Performer Full-Seat Breech in four-way stretch twill with core control is perfect for competition and schooling. Constructed to flatter, this ladies' full-seat breech has traditional styling plus Ariat's comfortable V3® waist for freedom of movement.
This Back On Track® Knee Brace Two-Pack offers convenience in treating both knees or for swapping out one brace while the other is cleaned. Ideal for riders and barn workers with sore knees, the braces use far infrared heat radiation to help relieve knee pain, disperse edema, reduce inflammation and relax muscles.
Riding Sport™ Bamboo Striped Socks incorporate bamboo fibers for natural moisture wicking and antimicrobial properties. These boot socks feature stay-put cuffs and thick cushioned soles for comfort.
Sized to hold an iPhone 4 or smaller phone, this Cell Phone Holder is an asset to any rider on the trail, in the barnyard or at the show grounds. Durable neoprene stands up to dirt and sweat. Tough hook-and-look closure keeps your phone secure.
The Charles Owen JL9 Body Protector offers a comfortable, non-restrictive fit. This JL9 protective riding vest by Charles Owen lets riders perform to the best of their abilities. ASTM F-1937-04/SEI Certified.


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Jeeves stories are the best of Wodehouse and Cecil is the best of narrators.Published 2 months ago by Sydney Wolf
Number four of four in the "Totleigh Towers series," Much Obliged, Jeeves is hilarious, weell written, and extremely entertaining, as always. If you already love P. G. Read morePublished 2 months ago by Craig
P.G.Wodehouse is a favorite writer of my families. Love Jeeves and Wooster and all their family and friends. Doesn't get any better!Published 15 months ago by Tay
wodehouse is always a 5 star guarantee and Much Obliged Jeeves is one of his best hits. I would always recommend it without hesitation.Published 16 months ago by manuel penia
This book is the only one where Jeeves concedes something at the end, unlike the usual MO of Bertie submitting to Jeeves' better judgment in the area of mustaches, dinner jackets,... Read morePublished 23 months ago by J. Henderson
ordered it, paid for it, got it, it's just that simple,,,, nine more words not needed at this time. capishPublished 23 months ago by Michael
Jeeves was a disappointing read for me unfortunately. Maybe my lack of interest was due to the events in my life at present, just couldn't warm to the book.Published on November 4, 2012 by Hannah
P.G is British humor at it's best! I've red most of his books and enjoyned each and every one of them.Published on September 1, 2011 by Diana
Fantastic wit! Loved it from start to finish.
My dad and I are huge Wodehouse fans and we quite enjoy trading quotes from this book. Read more


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Mayday Parade Post New Video
My review is coming along... Slowly!
Digging: Westkust - Last Forever
is it worth checking out? i know nothing about this band
this band is no longer really awesome
Digging: mewithoutYou - Pale Horses
I think it's anything but boring. It maybe needs to be a little more boring, in a strange kind of way.
Pretty good actually. Looking forward to hearing the whole album.
Wierdest video, but good song
• Brand New release new song as a f..• Tool + Mastodon supergroup• Slint guitarist survives suicide ..• Muse unleash new single• Scarlett Johansson forms band• Nickelback get groovy • New Muse song• Steven Wilson premieres new tune• B.B. King Dead• Brand New premiere new song
• Cattle Decap release 2nd song• Gravesite stream debut LP• New X Japan album and movie• New Celldweller song• Evergrey release third video• New Crystal Castles song• New Chief Keef song• New As Cities Burn Song• Soilwork tease new song• Riverside detail sixth album • New Christian Mistress Song• The Sword debut new tune• Rotting Christ to release live al..• Zao to release new material• New Zatokrev video» see all news
Bands: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


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A short 30-second TV spot for the upcoming season of awesome (read: 24) was picked up by SpoilerTV today and it shows exactly what we've come to expect from the season: intensity and action.
Titled "The World Hangs in the Balance," this trailer brings the power and energy as well as some looks at the new characters that the previous 24 Season 8 trailer from October didn't show. That one focused on the story and is a must-watch as well.
Check out the new teaser below.
Better yet, we get to see CTU New York start up again and some new characters added to the agency including Freddie Prinze, Jr. and Katee Sackhoff. Freddie Prinze Jr.!
Watch and enjoy:
I love 24 and I think Jack Bauer should fight terror forever until he ends it entirely.
What do you think of the latest for 24?
24 Season 8 is a mere few weeks away, premiering on January 17, 2010 on Fox.
Source: SpoilerTV


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After entering a guilty plea April 7 agreeing to a 12-year sentence for sex acts with a male relative, a Clarksville, Tennessee, man entered a pro se motion Tuesday in Hardin Circuit Court to withdraw the plea.
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The News-Enterprise is your source for local news, sports, events and information in Elizabethtown, KY, Hardin County and the surrounding area.


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Sidney James Mountain Lodge
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Suites
- Swimming pool
- Restaurant
- Free High-Speed Internet
- Wheelchair accessibility
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Historical Traveler Reviews Sidney James Mountain Lodge Gatlinburg
Deceived by brochure
We only lasted thirty minutes in our dark, dirty, and out-dated room.
Our room looked nothing like the ones in the brochure. There were black handprints on doors, and sticky stuff on light switch I went to use. We ate the cost of that night and left immediately and went somewhere else. The so-called balconies were a joke.
A great place to stay
We arrived at the Sidney James Mountain Lodge on 7/13/03 and stayed for 6 days - loved every minute of it. The desk staff and staff in the poolside cafe were exceptionally nice and accomodating. Inside and outside pools were very clean without the usual heavy chlorine pools that hotel pools tend to have. We had breakfast nearly every day in the poolside cafe which was quick with good food and very reasonable prices. My son loved playing in the creek! We will definitely be back!
Hated It
This was the worst place I have ever stayed in. You could call it a Roach Motel or better yet a Spider motel. We even asked for our money back right after we saw the room and they REFUSED to give us our money back.
What a dump!
The internet pictures made the Sidney James look very attractive when in fact the place is run down and filthy. I was so disappointed. They have a three-day cancellation notice and we were only staying 3 nights so we were stuck. I would not walk on the carpet after my shower because the carpet was sooooo dirty. With a lot of TLC the Sidney James could be nice but they obviously don't care about the upkeep. What a shame!
Loved it!
We recently stayed two nights at Sidney James and we loved it! Comfortable and convenient and the staff was VERY friendly and helpful. We definitely hope to go back again!
Great cottages and rooms!
We have stayed at the Sidney James 3 years in a row now, most recently in March of 2003. We have stayed in regular rooms, and rented a 3-bedroom cottage. The rooms are clean, the staff is friendly and courteous, and the rates are very reasonable. This appears to be a very family-friendly place to stay and is within easy walking distance to downtown. We will be back again next year!
Not so great
Entire facility is a little out of date. Was disappointed with the balcony size, its shallow depth prevented chairs. The HVAC unit mounted over the door had bare wires hanging out. And the fireplace wasn't operable. Overall experience was okay, but next time we'll look elsewhere. Townsend.
Great place to stay!
This hotel is AMAZING!
I highly recommend a small jaccuzzi suite...very nice for a low price....great staff friendly service...I have always and will continue still to stay at this hotel.
Great place to stay
The people have always been very professional. The rooms are wonderful.....get a jacuzzi suite overlooking the creek if you can. I have always stayed here and will continue to do so into the future.
Treated very rude and unprofessionally
we had reservations there 2 weeks ago on fri & sat night, we did not know until we checked in the room that was for "handicap". needless to say, with the way the room was adapted for such a person, we were quite inconvienced by it. upon calling the from desk to register several complaints, having to hold the shower head in your hand while showering, when heat was turned on there was an offensive odor, the smoke went off, the man who took the call was very rude and hung up on me. when we checked out a day early and went into the office to collect our refund for one night, no one in the office offered an apology, as a matter of fact they said nothing. we will never visit this hotel nor recommend it to anyone. sincerely, mitzi clayton
TripAdvisor Reviews Sidney James Mountain Lodge Gatlinburg
Travel Blogs from Gatlinburg
New Experiences!
... a chance to go above and beyond and learn more. I learned how to do weighted and unweighted transfers which is important skill to know for rescuing. I went above and learned how to set up top and bottom belay sights. I now feel comfortable going out and setting up a top rope sight by myself but having a certified knowledgeable body oversee. The instructor on this course even affirmed my knowledge of the ropes and encouraged me ...
Mission Support
... for as I have had limited chances to do so in the past. Implemented into the camp, I will be learning how to lead Bible studies and provide counseling and conflict resolution when needed.
The capstone of the summer with OMC is ...
... way clouds form from the ground up, and you can see what looks like campfire smoke rising
into the sky to become clouds or simply create a smoky haze.
We also drove part of the Blue Ridge Parkway and stepped onto the Appalachian Trail in the rain. The 4 of us put one foot in Tennessee and the other in South Carolina since both states straddle ...
Heigh Ho, Heigh Ho it's off to work we go!
... we pick on you, if means we like you." They teased us all day. We divided and conquered painting, sweeping, cleaning, and sharing the moment as we all put on our big girl pants. We embraced the stories they told and compared it to our own lives. We live in our own bubbles and hearing of the stories that take place blew our minds. The amount of poverty, suicide, and drug and alcohol abuse put things into perspective for us. Moral of the story it was an ...
Worship, Fellowship, Learning, and Fun, of course
Waking up in our cabins, feeling blessed in the beauty of our stay, our journey has officially begun. As we took off over the mountain for 11am church service at Living Waters. Pastor Jack and the congregation welcomed us with open arms and a sense of peace and serenity took over the room. A very small space with chairs lined up in rows facing one another Pastor Jack touched ...