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Office of Scientific and Technical Information
Engineering of a High-Throughput Screening System to Identify Cellulosic Biomass,
E-Print Network [OSTI]
- grated high-throughput (HTP) screening pipeline. Herein, we report on the engineering of a novel HTP
California at Riverside, University of
High-Throughput and Combinatorial Screening of Hydrogen Storage...
Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site
High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation) High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation)...
High Throughput/Combinatorial Screening of Hydrogen Storage Materials...
Broader source: Energy.gov (indexed) [DOE]
UOP LLC. All rights reserved. High ThroughputCombinatorial Screening of Hydrogen Storage Materials: UOP Approaches High ThroughputCombinatorial Screening of Hydrogen Storage...
High throughput protein production screening
DOE Patents [OSTI]
Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.
Beernink, Peter T. (Walnut Creek, CA); Coleman, Matthew A. (Oakland, CA); Segelke, Brent W. (San Ramon, CA)
Materials: UOP Approaches High ThroughputCombinatorial Screening of Hydrogen Storage Materials: UOP Approaches Presentation by Adriaan Sachtler from the High Throughput...
Materials (presentation) High ThroughputCombinatorial Screening of Hydrogen Storage Materials (presentation) Presented at the U.S. Department of Energy's Hydrogen Storage Meeting...
High Throughput Combinatorial Screening of Biometic Metal-Organic...
High Throughput Combinatorial Screening of Biometic Metal-Organic Materials for Military Hydrogen-Storage Materials (New Joint Miami UNREL DoDDLA Project) (presentation) High...
Microfluidic Technologies for High-Throughput Screening Applications
Microfluidic Technologies for High-Throughput Screening Applications Thesis by Todd Thorsen, patiently giving me advice on a large variety of subjects, ranging from microfluidics to optics of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed
Quake, Stephen R.
Development and optimization of high-throughput zebrafish screening platform
The high-throughput zebrafish screening platform is a revolutionary tool that enables subcellular precision in vivo whole animal screening of Danio Rerio. It can perform laser surgery and/or imaging in less than twenty ...
Koo, Bryan Kyo
High-throughput vertebrate total analysis/screening platform
High-throughput screening (HTS) is seen as one of the most promising technologies to facilitate biomedical studies and pharmaceutical discoveries. Although large varieties of in vitro HTS technologies have opened great ...
Chang, Tsung-Yao, Ph. D. Massachusetts Institute of Technology
High throughput optical sensor arrays for drug screening
In the world of drug discovery, high throughput whole cell assays are a critical step in discovering therapeutically relevant drug compounds [1]. This report details the development of several novel sensor systems capable ...
Harjes, Daniel I
DOE Workshop HIGH THROUGHPUT/COMBINATORIAL SCREENING
Optimization: 2o Screening Lab Reactor Pilot Plant Plant Experiments per day Symyx Industry 1000's 100's 10's 1 · Parallel Reactor Technology · HT Polymer Characterization · Heterogeneous Catalysis · Substrate Synthesis · Catalyst Preparation · Parallel Reactor Technology · HT Product Characterization · Specialty Polymers
Research Focus High-throughput screens for fluorescent dye discovery
Research Focus High-throughput screens for fluorescent dye discovery Vebjorn Ljosa and Anne E of a combinatorial library of fluorescent compounds discovered fluorescent dyes that were able to distinguish myoblasts from differentiated myotubes. New fluorescent dyes that respond to biologically relevant changes
Carpenter, Anne E.
High throughput chemical munitions treatment system
A new High-Throughput Explosive Destruction System is disclosed. The new system is comprised of two side-by-side detonation containment vessels each comprising first and second halves that feed into a single agent treatment vessel. Both detonation containment vessels further comprise a surrounding ventilation facility. Moreover, the detonation containment vessels are designed to separate into two half-shells, wherein one shell can be moved axially away from the fixed, second half for ease of access and loading. The vessels are closed by means of a surrounding, clam-shell type locking seal mechanisms.
Haroldsen, Brent L. (Manteca, CA); Stofleth, Jerome H. (Albuquerque, NM); Didlake, Jr., John E. (Livermore, CA); Wu, Benjamin C-P (San Ramon, CA)
Agenda from the U.S. Department of Energy's High Throughput Screening...
from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Agenda from the U.S. Department of Energy's High Throughput...
technologies and software to increase R&D efficiency in chemical, energy, electronics, pharmaceutical and academic labs. * Pioneer of High Throughput Research (HTR) for...
Advances in High Throughput Screening of Biomass Recalcitrance (Poster)
SciTech Connect (OSTI)
This was a poster displayed at the Symposium. Advances on previous high throughput screening of biomass recalcitrance methods have resulted in improved conversion and replicate precision. Changes in plate reactor metallurgy, improved preparation of control biomass, species-specific pretreatment conditions, and enzymatic hydrolysis parameters have reduced overall coefficients of variation to an average of 6% for sample replicates. These method changes have improved plate-to-plate variation of control biomass recalcitrance and improved confidence in sugar release differences between samples. With smaller errors plant researchers can have a higher degree of assurance more low recalcitrance candidates can be identified. Significant changes in plate reactor, control biomass preparation, pretreatment conditions and enzyme have significantly reduced sample and control replicate variability. Reactor plate metallurgy significantly impacts sugar release aluminum leaching into reaction during pretreatment degrades sugars and inhibits enzyme activity. Removal of starch and extractives significantly decreases control biomass variability. New enzyme formulations give more consistent and higher conversion levels, however required re-optimization for switchgrass. Pretreatment time and temperature (severity) should be adjusted to specific biomass types i.e. woody vs. herbaceous. Desalting of enzyme preps to remove low molecular weight stabilizers and improved conversion levels likely due to water activity impacts on enzyme structure and substrate interactions not attempted here due to need to continually desalt and validate precise enzyme concentration and activity.
Turner, G. B.; Decker, S. R.; Tucker, M. P.; Law, C.; Doeppke, C.; Sykes, R. W.; Davis, M. F.; Ziebell, A.
High-Throughput Thin Film Approach for Screening of Temperature-Pressure-Composition Phase Space
Many solar energy technologies, for example CIGS and CdTe photovoltaics, utilize materials in thin film form. The equilibrium phase diagrams for these and other more novel solar energy materials are not known or are irrelevant because of the non-equilibrium character of the thin film growth processes. We demonstrate a high-throughput thin film approach for screening of temperature-pressure-composition phase diagrams and phase spaces. The examples in focus are novel solar absorbers Cu-N, Cu-O and p-type transparent conductors in the Cr2O3-MnO system. The composition axis of the Cr2O3-MnO phase diagram was screened using a composition spread method. The temperature axis of the Mn-O phase diagram was screened using a temperature spread method. The pressure axes of the Cu-N and Cu-O phase diagrams were screened using rate spread method with the aid of non-equilibrium growth phenomena. Overall these three methods constitute an approach to high-throughput screening of inorganic thin film phase diagrams. This research is supported by U.S. Department of Energy as a part of two NextGen Sunshot projects and an Energy Frontier Research Center.
Zakutayev, A.; Subramaniyan, A.; Caskey, C. M.; Ndione, P. F.; Richards, R. M.; O'Hayre, R.; Ginley, D. S.
Methods and technologies for high-throughput and high-content small animal screening
High-throughput and high-content screening (HTS and HCS) of whole animals requires their immobilization for high-resolution imaging and manipulation. Here we present methods to enable HTS and HCS of the nematode Caenorhabditis ...
Rohde, Christopher, 1979-
Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium tuberculosis
infection. High Throughput Screening can be used to both find and analyze promising drug candidates. Using automation, thousands of compounds can be tested against an attenuated strain of Tuberculosis and separate the promising compounds from the ineffective...
LaiHing, Steven 1983-
Combined Catalysis and Optical Screening for High Throughput Discovery of Solar Fuels Catalysts
Combined Catalysis and Optical Screening for High Throughput Discovery of Solar Fuels Catalysts J,b a Joint Center for Artificial Photosynthesis, California Institute of Technology, Pasadena, California 91125, USA b Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720
Faraon, Andrei
High throughput solar cell ablation system
A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.
Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John
Droplet microfluidic technology for single-cell high-throughput screening
Droplet microfluidic technology for single-cell high-throughput screening Eric Brouzesa,b,1 (received for review March 31, 2009) We present a droplet-based microfluidic technology that enables high our droplet microfluidic platform is modular, robust, uses no moving parts, and has a wide range
Perrimon, Norbert
Optical microplates for high-throughput screening of photosynthesis in lipid-producing algae{,
Optical microplates for high-throughput screening of photosynthesis in lipid- producing algae-producing algae of interest in 2nd generation biofuels. By conducting 96 experiments in parallel, photoirradiance the study of photosynthesis in algae. Societal challenges in energy sustainability have renewed interest
Basu, Amar S.
High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays
High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays RANDOLPH S. ASHTON,a JOSEPH PELTIER,b CHRISTOPHER A. FASANO,c ANALEAH O'NEILL,b JOSHUA LEONARD,b SALLY TEMPLE,c DAVID. Sox2 transcription factor � Akt1 � Neural progenitor cells � Soft lithography ABSTRACT We describe
Schaffer, David V.
Discovery and High-Throughput Screening of Heteroleptic Iridium Complexes for Photoinduced Hydrogen Production
high-throughput photophysical techniques, to identify six potential photosensitizers for use researchers. Simple solar devices focus or collect sunlight, harnessing radiation in order to heat dwellings or drive turbines. Photovoltaic cells can convert solar radiation directly to electrical current
Bernhard, Stefan
The Materials genome : rapid materials screening for renewable energy using high-throughput density functional theory
This thesis relates to the emerging field of high-throughput density functional theory (DFT) computation for materials design and optimization. Although highthroughput DFT is a promising new method for materials discovery, ...
Jain, Anubhav, Ph.D. Massachusetts Institute of Technology
Constant pressure high throughput membrane permeation testing system
The disclosure relates to a membrane testing system for individual evaluation of a plurality of planar membranes subjected to a feed gas on one side and a sweep gas on a second side. The membrane testing system provides a pressurized flow of a feed and sweep gas to each membrane testing cell in a plurality of membrane testing cells while a stream of retentate gas from each membrane testing cell is ported by a retentate multiport valve for sampling or venting, and a stream of permeate gas from each membrane testing cell is ported by a permeate multiport valve for sampling or venting. Back pressure regulators and mass flow controllers act to maintain substantially equivalent gas pressures and flow rates on each side of the planar membrane throughout a sampling cycle. A digital controller may be utilized to position the retentate and permeate multiport valves cyclically, allowing for gas sampling of different membrane cells over an extended period of time.
Albenze, Erik J.; Hopkinson, David P.; Luebke, David R.
High Throughput Sample Preparation and Analysis for DNA Sequencing, PCR and Combinatorial Screening of Catalysis Based on Capillary Array Technique
Sample preparation has been one of the major bottlenecks for many high throughput analyses. The purpose of this research was to develop new sample preparation and integration approach for DNA sequencing, PCR based DNA analysis and combinatorial screening of homogeneous catalysis based on multiplexed capillary electrophoresis with laser induced fluorescence or imaging UV absorption detection. The author first introduced a method to integrate the front-end tasks to DNA capillary-array sequencers. protocols for directly sequencing the plasmids from a single bacterial colony in fused-silica capillaries were developed. After the colony was picked, lysis was accomplished in situ in the plastic sample tube using either a thermocycler or heating block. Upon heating, the plasmids were released while chromsomal DNA and membrane proteins were denatured and precipitated to the bottom of the tube. After adding enzyme and Sanger reagents, the resulting solution was aspirated into the reaction capillaries by a syringe pump, and cycle sequencing was initiated. No deleterious effect upon the reaction efficiency, the on-line purification system, or the capillary electrophoresis separation was observed, even though the crude lysate was used as the template. Multiplexed on-line DNA sequencing data from 8 parallel channels allowed base calling up to 620 bp with an accuracy of 98%. The entire system can be automatically regenerated for repeated operation. For PCR based DNA analysis, they demonstrated that capillary electrophoresis with UV detection can be used for DNA analysis starting from clinical sample without purification. After PCR reaction using cheek cell, blood or HIV-1 gag DNA, the reaction mixtures was injected into the capillary either on-line or off-line by base stacking. The protocol was also applied to capillary array electrophoresis. The use of cheaper detection, and the elimination of purification of DNA sample before or after PCR reaction, will make this approach an attractive alternative to current methods for genetic analysis and disease diagnosis.
Yonghua Zhang
E-Print Network 3.0 - automated high-throughput screening Sample...
Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)
more rapidly screen large numbers of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio- Summary: in the cost of biofuel...
Getter sputtering system for high-throughput fabrication of composition spreads
We describe a sputtering system that can deposit composition spreads in an effectively UHV environment but which does not require the high-throughput paradigm to be compromised by a long pump down each time a target is changed. The system deploys four magnetron sputter guns in a cryoshroud (getter sputtering) which allows elements such as Ti and Zr to be deposited with minimal contamination by oxygen or other reactive background gases. The system also relies on custom substrate heaters to give rapid heating and cool down. The effectiveness of the gettering technique is evaluated, and example results obtained for catalytic activity of a pseudoternary composition spread are presented.
Gregoire, John M.; Dover, R. B. van; Jin Jing; Di Salvo, Francis J.; Abruna, Hector D. [Department of Physics, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States)
High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
and negative controls to make the calculation. Robust statistics [32], which minimizes the effects of outliers on the statistical analysis, were used to calculate the median, robust standard deviation (rSD) and the robust percent coefficient of variance (%r....041 � 13 rSD). The Microsource compounds were part of a previously published screen [29] that had a Z-factor of 0.62 � 0.09. The Z-factors for the TimTec and Analyticon screens were 0.77 � 0.18 and 0.64 � 0.14, respectively. The %rCV for the screens...
Davenport, Jason; Blach, Maurie; Galam, Lakshmi; Girgis, Antwan; Hall, Jessica; Blagg, Brian S. J.; Matts, Robert L.
A General Framework for Development and Data Analysis of Competitive High-Throughput Screens for Small-Molecule Inhibitors of Protein-Protein
). Recent advances in chemical biology and high-throughput (HTP)1 screening (13-15) have introduced the use sensitive, robust, and widely used HTP methods for the study of protein interactions and drug discovery (19, can serve as a sensitive molecular sensor. HTP FP assays usually detect changes in polarization caused
Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis
P.J. , & Lee, L.P. , Microfluidics-based systems biology.T.M. & Quake, S.R. , Microfluidics: Fluid physics at theand applications of microfluidics in biology. Annu Rev
Hui, Lawrence Kwan Yeung
A High-Throughput Screen for Wnt/?-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors
Wnt/?-catenin signaling has emerged as a central player in pathways implicated in the pathophysiology and treatment of neuropsychiatric disorders. To identify potential novel therapeutics for these disorders, high-throughput ...
Zhao, Wen-Ning
Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System
This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...
Sobahi, Nebras MohammedKamal A.
Integrated Controlling System and Unified Database for High Throughput Protein Crystallography Experiments
An integrated controlling system and a unified database for high throughput protein crystallography experiments have been developed. Main features of protein crystallography experiments (purification, crystallization, crystal harvesting, data collection, data processing) were integrated into the software under development. All information necessary to perform protein crystallography experiments is stored (except raw X-ray data that are stored in a central data server) in a MySQL relational database. The database contains four mutually linked hierarchical trees describing protein crystals, data collection of protein crystal and experimental data processing. A database editor was designed and developed. The editor supports basic database functions to view, create, modify and delete user records in the database. Two search engines were realized: direct search of necessary information in the database and object oriented search. The system is based on TCP/IP secure UNIX sockets with four predefined sending and receiving behaviors, which support communications between all connected servers and clients with remote control functions (creating and modifying data for experimental conditions, data acquisition, viewing experimental data, and performing data processing). Two secure login schemes were designed and developed: a direct method (using the developed Linux clients with secure connection) and an indirect method (using the secure SSL connection using secure X11 support from any operating system with X-terminal and SSH support). A part of the system has been implemented on a new MAD beam line, NW12, at the Photon Factory Advanced Ring for general user experiments.
Gaponov, Yu.A.; Igarashi, N.; Hiraki, M.; Sasajima, K.; Matsugaki, N.; Suzuki, M.; Kosuge, T.; Wakatsuki, S. [Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba (Japan)
Automated high-throughput flow-through real-time diagnostic system
An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system.
Regan, John Frederick
Development of High-throughput and Robust Microfluidic Live Cell Assay Platforms for Combination Drug and Toxin Screening
the labor-intensive and time-consuming limitations, they are too costly for general users. Microfluidic live cell screening platforms can allow precise control of cell culture microenvironments by applying accurate doses of biomolecular mixtures...
Wang, Han
HiTSEE: A Visualization Tool for Hit Selection and Analysis in High-Throughput Screening Experiments
importantly the lack of temporal control required to study dynamic processes, since a protein cannot be turned a cellular system and to elucidate the function of proteins. As genes encode proteins, gene function can be modu- lated through a mutation, which in turn perturbs the function of the protein of interest
Deussen, Oliver
High Throughput Web Inspection System using Time-stretch Real-time Imaging
successfully report a dark-field web inspection system withsample substrate for our dark-field web inspection systemweb inspection system exploiting time- stretch and utilizing the merits coming from dark-
Kim, Chanju
Applied Catalysis A: General 254 (2003) 97106 Photoionization detection (PID) as a high throughput
Applied Catalysis A: General 254 (2003) 97106 Photoionization detection (PID) as a high throughput 2002 Abstract A versatile photoionization detection (PID) system has been developed to rapidly screen libraries of catalytic materials. The PID approach involves the use of an appropriately selected dc
Senkan, Selim M.
High throughput optical scanner
A scanning apparatus is provided to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction, comprising a light source, a scanning mirror to receive light from the light source and sweep it across a steering mirror, a steering mirror to receive light from the scanning mirror and reflect it to the substrate, whereby it is swept across the substrate along a scan arc, and a photodetector to receive emitted or scattered light from the substrate, wherein the optical path length from the light source to the photodetector is substantially constant throughout the sweep across the substrate. The optical train can further include a waveguide or mirror to collect emitted or scattered light from the substrate and direct it to the photodetector. For phase-sensitive detection the light source is intensity modulated and the detector is connected to phase-sensitive detection electronics. A scanner using a substrate translator is also provided. For two dimensional imaging the substrate is translated in one dimension while the scanning mirror scans the beam in a second dimension. For a high throughput scanner, stacks of substrates are loaded onto a conveyor belt from a tray feeder.
Basiji, David A. (Seattle, WA); van den Engh, Gerrit J. (Seattle, WA)
High-Throughput Screening for Functional Adenosine to Inosine RNA Editing Systems
and Peter A. Beal* Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah sequence changes to maintain an open reading frame and create a stop codon *Corresponding author, beal
Beal, Peter A.
automating high-throughput blast: Topics by E-print Network
to electron transfer dissoci- ation (ETD) mass spectrometry Shorter, James 15 Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium...
Robofurnace: A semi-automated laboratory chemical vapor deposition system for high-throughput nanomaterial synthesis and process discovery
Laboratory research and development on new materials, such as nanostructured thin films, often utilizes manual equipment such as tube furnaces due to its relatively low cost and ease of setup. However, these systems can be prone to inconsistent outcomes due to variations in standard operating procedures and limitations in performance such as heating and cooling rates restrict the parameter space that can be explored. Perhaps more importantly, maximization of research throughput and the successful and efficient translation of materials processing knowledge to production-scale systems, relies on the attainment of consistent outcomes. In response to this need, we present a semi-automated lab-scale chemical vapor deposition (CVD) furnace system, called �Robofurnace.� Robofurnace is an automated CVD system built around a standard tube furnace, which automates sample insertion and removal and uses motion of the furnace to achieve rapid heating and cooling. The system has a 10-sample magazine and motorized transfer arm, which isolates the samples from the lab atmosphere and enables highly repeatable placement of the sample within the tube. The system is designed to enable continuous operation of the CVD reactor, with asynchronous loading/unloading of samples. To demonstrate its performance, Robofurnace is used to develop a rapid CVD recipe for carbon nanotube (CNT) forest growth, achieving a 10-fold improvement in CNT forest mass density compared to a benchmark recipe using a manual tube furnace. In the long run, multiple systems like Robofurnace may be linked to share data among laboratories by methods such as Twitter. Our hope is Robofurnace and like automation will enable machine learning to optimize and discover relationships in complex material synthesis processes.
Oliver, C. Ryan; Westrick, William; Koehler, Jeremy; Brieland-Shoultz, Anna; Anagnostopoulos-Politis, Ilias; Cruz-Gonzalez, Tizoc [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States)] [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Hart, A. John, E-mail: email@example.com [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)
Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods
This report summarizes the work completed under the U.S. Department of Energy Project Award No.: DE-FE0001181 titled �Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods.� The project started in October 1, 2009 and was finished September 30, 2014. Pall Corporation worked with Cornell University to sputter and test palladium-based ternary alloys onto silicon wafers to examine many alloys at once. With the specialized equipment at Georgia Institute of Technology that analyzed the wafers for adsorbed carbon and sulfur species six compositions were identified to have resistance to carbon and sulfur species. These compositions were deposited on Pall AccuSep� supports by Colorado School of Mines and then tested in simulated synthetic coal gas at the Pall Corporation. Two of the six alloys were chosen for further investigations based on their performance. Alloy reproducibility and long-term testing of PdAuAg and PdZrAu provided insight to the ability to manufacture these compositions for testing. PdAuAg is the most promising alloy found in this work based on the fabrication reproducibility and resistance to carbon and sulfur. Although PdZrAu had great initial resistance to carbon and sulfur species, the alloy composition has a very narrow range that hindered testing reproducibility.
Lewis, Amanda; Zhao, Hongbin; Hopkins, Scott
494 IEEE TRANSACTIONS ON VERY LARGE SCALE INTEGRATION (VLSI) SYSTEMS, VOL. 13, NO. 4, APRIL 2005 Memory Sub-Banking Scheme for High Throughput
decoding latency, and reduced memory energy consumption. Our contributions include deriva- tion, and energy consumption and provide a tradeoff analysis between the different parameters. The main implementations (both single port and dual port) of the SW SISO decoder that achieves high throughput, low
Kambhampati, Subbarao
High-Throughput and Combinatorial Screening
, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL Hydride + H2 Complex Hydride Boride + Binary Hydride + H2 Metal Borohydride We can test six samples per vessel design complete 15 sample hotplates, 3 gas detectors Achieve sample temperatures of 1200 K and H
Attendees list from the U.S. Department of Energy's High Throughput...
Attendees list from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Attendees list from the U.S. Department of...
High-throughput quantification of glycoprotein sialylation
Sialic acid can improve qualities of therapeutic glycoproteins, such as circulatory half-life, biological activity, and solubility. In production of therapeutic glycoproteins, a high-throughput method (HTM) is required for ...
Markely, Lam Raga Anggara
High Throughput Materials Characterization John M. Gregoire
Paper for Establishing a User Facility for Synchrotron-based High Throughput Materials Characterization John M. Gregoire 1 , Matthew J. Kramer 2 , Apurva Mehta 3 1 Joint Center for...
High-throughput Process Development
.2 Screening experiments in PreDictor plates vs small-scale columns....................................5 1 Chromatography Principles and Methods 18-1022-29 Antibody Purification Handbook 18-1037-46 Ion Exchange Protein Purification Handbook Principles and Methods 18-1142-75 Protein Purification Handbook 18
Lebendiker, Mario
High-Throughput/Combinatorial Techniques in Hydrogen Storage...
High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation) High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation)...
Potential of High-Throughput Experimentation with Ammonia Borane...
of High-Throughput Experimentation with Ammonia Borane Solid Hydrogen Storage Materials (presentation) Potential of High-Throughput Experimentation with Ammonia Borane Solid...
High-throughput metal nanoparticle catalysis by pulsed laser ablation Selim Senkan a,*, Michael Kahn a
High-throughput metal nanoparticle catalysis by pulsed laser ablation Selim Senkan a,*, Michael online 18 July 2006 Abstract A high-throughput pulsed laser ablation (HT-PLA) system was developed-TEM) and energy dispersive X-ray (EDX) spectroscopy, respectively. The supported nanoparticles created by HT
A high-throughput infrastructure for density functional theory calculations Anubhav Jain, Geoffroy Hautier, Charles J. Moore, Shyue Ping Ong, Christopher C. Fischer,
A high-throughput infrastructure for density functional theory calculations Anubhav Jain, Geoffroy-throughput computation Density functional theory Materials screening GGA Formation enthalpies a b s t r a c t The use of high-throughput density functional theory (DFT) calculations to screen for new materials and conduct
Ceder, Gerbrand
HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC SEPARATION Michael D. Vahey conductivity. Using a re- cently developed separation method - iso-dielectric separation (IDS) - we character for developing new screens. THEORY We recently developed a separa- tion method, called iso-dielectric sepa
Voldman, Joel
A microfluidic platform for high-throughput multiplexed protein quantitation
We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of capture and detection antibody. Samples are quantitated in each unit cell by four independent MITOMI detection areas, allowing four samples to be analyzed in parallel for a total of 1,536 assays per device. We show that the device can be pre-assembled and stored for weeks at elevated temperature and we performed proof-of-concept experiments simultaneously quantitating IL-6, IL-1\\b{eta}, TNF-{\\alpha}, PSA, and GFP. Finally, we show that the platform can be used to identify functional antibody combinations by screening 64 antibody combinations requiring up to 384 unique assays per device.
Volpetti, Francesca; Maerkl, Sebastian
High Throughput Operando Studies using Fourier Transform Infrared...
Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman Spectroscopy. High Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman...
A High-Throughput Macromolecule Characterization System
stability of macromolecules in response to various environmental perturbations. Numerous proteins and macromolecular complexes have been analyzed by EPDs to summarize results from large data sets from multiple biophysical techniques. The current EPD method...
Kim, Jae Hyun
ORIGINAL ARTICLE Combining high-throughput sequencing with fruit
ORIGINAL ARTICLE Combining high-throughput sequencing with fruit body surveys reveals contrasting communities were mostly confined to fruit bodies, whereas mycelial interactions were studied in the laboratory. Here we combine high-throughput sequencing with a fruit body inventory to study simultaneously mycelial
Bruns, Tom
- 50 cm -1 ) red-shifts upon adsorption *Can be complex, depending on exact adsorption environment *Partial charge transfer weakens H-H bond, red-shift *Are such strong...
method The sintering technique is used by groups at: U. Geneva (Switzerland), MPI (Germany), Stockholm University (Sweden), IFE (Norway), SRNL (USA), U. Tohoku, AIST (Japan)...
High Throughput Combinatorial Screening of Biometic Metal-Organic Materials
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground Hawaii HIGH PERFORMANCE andHighWellsfor Military
High Throughput/Combinatorial Screening of Hydrogen Storage Materials
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High Throughput/Combinatorial Screening of Hydrogen Storage Materials: UOP
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High-Throughput and Combinatorial Screening of Hydrogen Storage Materials
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NETL Studies High Throughput Membrane Screening | netl.doe.gov
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Opticalhttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gifAEnergy Scientist Named FinalistNETLNETL
FastForward: High-Throughput Dual-Radio Streaming Gholamhossein Ekbatanifard
amount of data at high throughput and/or low latency. For example, structural health of the Golden Gate end-to-end throughput is limited to 1/2 the radio capacity. To bridge this performance gap we present Bridge was sampled at 1 KHz in [1]. Brimon, a railway monitoring system, generates about 7 KB in each
Kuzmanov, Georgi
Storage (New DoDDLA Project), Ali T-Raissi, University of Central Florida, Florida Solar Energy Center High-Throughput Methodology for Discovery of Metal-Organic Frameworks...
Temperature response of the ultra-high throughput mutational spectrometer
The Ultra-High Throughput Mutational Spectrometer is an instrument designed to separate mutant from wild type DNA through capillary electrophoresis. Since this technique uses the melting point of the molecule to distinguish ...
Suen, Timothy W. (Timothy Wu)
New Tools for High Throughput Chemistry and Biology�
New strategies for the high-throughput determination of protease substrate specificity using a dual colour microarray based format with a small library of FRET-based peptides were developed. Integral to this process was ...
Galveia, Luciano Paulo Rosa
High Throughput Spectrum-aware Routing for Cognitive Radio Networks
High Throughput Spectrum-aware Routing for Cognitive Radio Networks Ashwin Sampath, Lei Yang, Lili, wireless nodes equipped with cognitive radios [11] do not operate on statically as- signed spectrum who own the spectrum, e.g. analog TV broadcast stations. Such flexibility means cognitive radios can
Zhao, Ben Y.
High Throughput Spectrumaware Routing for Cognitive Radio Networks
High Throughput Spectrumaware Routing for Cognitive Radio Networks Ashwin Sampath, Lei Yang, Lili, wireless nodes equipped with cognitive radios [11] do not operate on statically as signed spectrum. Instead, they identify and use locally unused licensed spectrum while avoiding disruptions to legacy users
High throughput liquid absorption preconcentrator sampling instrument
A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.
Zaromb, S.; Bozen, R.M.
Updating Interconnection Screens for PV System Integration
Abraham Ellis, Roger Hill Sandia National Laboratories Tom Key, Kristen Nicole, Jeff Smith Electric Power Research Institute Updating Interconnection Screens for PV System...
IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 32, NO. 10, OCTOBER 2013 1791 DevStaR: High-Throughput Quantification
of C. elegans embryonic viability in high-throughput (HTP) applications. A leading genetic model organism for the study of animal development and behavior, C. elegans is particularly amenable to HTP the algorithmic design of the DevStaR system and demonstrate its performance in scoring image data acquired in HTP
Sontag, Eduardo
A high throughput (>90%), large compensation range, single-prism femtosecond pulse compressor
We demonstrate a high throughput, large compensation range, single-prism femtosecond pulse compressor, using a single prism and two roof mirrors. The compressor has zero angular dispersion, zero spatial dispersion, zero pulse-front tilt, and unity magnification. The high efficiency is achieved by adopting two roof mirrors as the retroreflectors. We experimentally achieved ~ -14500 fs2 group delay dispersion (GDD) with 30 cm of prism tip-roof mirror prism separation, and ~90.7% system throughput with the current implementation. With better components, the throughput can be even higher.
Kong, Lingjie
This white paper evaluates the origins and usefulness of the capacity penetration screen, offer short-term solutions which could effectively allow fast-track interconnection to many PV system applications, and considers longer-term solutions for increasing PV deployment levels in a safe and reliable manner while reducing or eliminating the emphasis on the penetration screen. Short-term and longer-term alternatives approaches are offered as examples; however, specific modifications to screening procedures should be discussed with stakeholders and must ultimately be adopted by state and federal regulatory bodies.
Coddington, M.; Mather, B.; Kroposki, B.; Lynn, K.; Razon, A.; Ellis, A.; Hill, R.; Key, T.; Nicole, K.; Smith, J.
Generalized schemes for high throughput manipulation of the Desulfovibrio vulgaris Hildenborough genome
The ability to conduct advanced functional genomic studies of the thousands of sequenced bacteria has been hampered by the lack of available tools for making high- throughput chromosomal manipulations in a systematic manner that can be applied across diverse species. In this work, we highlight the use of synthetic biological tools to assemble custom suicide vectors with reusable and interchangeable DNA �parts� to facilitate chromosomal modification at designated loci. These constructs enable an array of downstream applications including gene replacement and creation of gene fusions with affinity purification or localization tags. We employed this approach to engineer chromosomal modifications in a bacterium that has previously proven difficult to manipulate genetically, Desulfovibrio vulgaris Hildenborough, to generate a library of over 700 strains. Furthermore, we demonstrate how these modifications can be used for examining metabolic pathways, protein-protein interactions, and protein localization. The ubiquity of suicide constructs in gene replacement throughout biology suggests that this approach can be applied to engineer a broad range of species for a diverse array of systems biological applications and is amenable to high-throughput implementation.
Chhabra, S.R.; Butland, G.; Elias, D.; Chandonia, J.-M.; Fok, V.; Juba, T.; Gorur, A.; Allen, S.; Leung, C.-M.; Keller, K.; Reveco, S.; Zane, G.; Semkiw, E.; Prathapam, R.; Gold, B.; Singer, M.; Ouellet, M.; Sazakal, E.; Jorgens, D.; Price, M.; Witkowska, E.; Beller, H.; Hazen, T.C.; Biggin, M.; Auer, M.; Wall, J.; Keasling, J.
Soft inertial microfluidics for high throughput separation of bacteria from human blood cells
Soft inertial microfluidics for high throughput separation1 Introduction Microfluidics has gained significant advancesof mammalian cells using microfluidics 3,4 , there have been
Wu, Zhigang
Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide.
??Abstract Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide by Dennis Pleskot Master of Science, Graduate Program in Materials Science and Engineering University� (more)
Pleskot, Dennis
Smart Screening System (S3) In Taconite
The conventional screening machines used in processing plants have had undesirable high noise and vibration levels. They also have had unsatisfactorily low screening efficiency, high energy consumption, high maintenance cost, low productivity, and poor worker safety. These conventional vibrating machines have been used in almost every processing plant. Most of the current material separation technology uses heavy and inefficient electric motors with an unbalanced rotating mass to generate the shaking. In addition to being excessively noisy, inefficient, and high-maintenance, these vibrating machines are often the bottleneck in the entire process. Furthermore, these motors, along with the vibrating machines and supporting structure, shake other machines and structures in the vicinity. The latter increases maintenance costs while reducing worker health and safety. The conventional vibrating fine screens at taconite processing plants have had the same problems as those listed above. This has resulted in lower screening efficiency, higher energy and maintenance cost, and lower productivity and workers safety concerns. The focus of this work is on the design of a high performance screening machine suitable for taconite processing plants. SmartScreens{trademark} technology uses miniaturized motors, based on smart materials, to generate the shaking. The underlying technologies are Energy Flow Control{trademark} and Vibration Control by Confinement{trademark}. These concepts are used to direct energy flow and confine energy efficiently and effectively to the screen function. The SmartScreens{trademark} technology addresses problems related to noise and vibration, screening efficiency, productivity, and maintenance cost and worker safety. Successful development of SmartScreens{trademark} technology will bring drastic changes to the screening and physical separation industry. The final designs for key components of the SmartScreens{trademark} have been developed. The key components include smart motor and associated electronics, resonators, and supporting structural elements. It is shown that the smart motors have an acceptable life and performance. Resonator (or motion amplifier) designs are selected based on the final system requirement and vibration characteristics. All the components for a fully functional prototype are fabricated and have been tested.
Daryoush Allaei
HIGH-THROUGHPUT/COMBINATORIAL TECHNIQUES IN HYDROGEN STORAGE MATERIALS R&D WORKSHOP U.S. Department 26, 2007, DOE's Hydrogen Storage Program held a one-day High- Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D meeting to identify how to better implement high
High throughput energy efficient multi-FFT architecture on FPGAs (Draft)
computing, High throughput FFT, Energy efficient design I. INTRODUCTION As FPGAs are programmed specifically in spread spec- trum receiver [4]. In the design of high throughput FFT architectures, energy-efficient design techniques can be used to maximize performance under power dissipation constraints. The power
Prasanna, Viktor K.
High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation
High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation a microfluidic approach for high-throughput generation of 3D microenvironments with different elasticity for studies of cell fate. The generation of agarose microgels with different elastic moduli was achieved by (i
Zandstra, Peter W.
Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo Decoder
Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable email@example.com, firstname.lastname@example.com Abstract--Parallel architecture is required for high throughput turbo decoder to meet also shows great flexibility and scalability compared to prior work. Index Terms--VLSI, turbo decoder
Mellor-Crummey, John
Grid Workflow Software for a High-Throughput Proteome Annotation Pipeline
Grid Workflow Software for a High-Throughput Proteome Annotation Pipeline Adam Birnbaum1 , James-Throughput Proteome 69 Protein Data Bank [9]. Despite the advent of high throughput crystallization pipelines [25 Annotation Pipeline (iGAP) [28]. iGAP, which incorporates a number of well established bioinformatics
Bourne, Philip E.
CONTINUOUS ROLL-TO-ROLL SERPENTINE DEPOSITION FOR HIGH THROUGHPUT a-Si PV MANUFACTURING
a number of advantages in a fully automated high throughput PV module production plant [l-18--a significant problem in many glass substrate amorphous silicon alloy PV module manufacturing plants. ECDCONTINUOUS ROLL-TO-ROLL SERPENTINE DEPOSITION FOR HIGH THROUGHPUT a-Si PV MANUFACTURING M. Izu, H
Deng, Xunming
Heterogeneous High Throughput Scientific Computing with APM X-Gene and Intel Xeon Phi
Electrical power requirements will be a constraint on the future growth of Distributed High Throughput Computing (DHTC) as used by High Energy Physics. Performance-per-watt is a critical metric for the evaluation of computer architectures for cost- efficient computing. Additionally, future performance growth will come from heterogeneous, many-core, and high computing density platforms with specialized processors. In this paper, we examine the Intel Xeon Phi Many Integrated Cores (MIC) co-processor and Applied Micro X-Gene ARMv8 64-bit low-power server system-on-a-chip (SoC) solutions for scientific computing applications. We report our experience on software porting, performance and energy efficiency and evaluate the potential for use of such technologies in the context of distributed computing systems such as the Worldwide LHC Computing Grid (WLCG).
David Abdurachmanov; Brian Bockelman; Peter Elmer; Giulio Eulisse; Robert Knight; Shahzad Muzaffar
automated high throughput: Topics by E-print Network
of such a more database-centric approach. Roehm, Uwe 2009-01-01 31 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites...
Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing
High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...
Larman, Harry Benjamin
An instrument for high-throughput measurements of fiber mechanical properties
In this thesis, an instrument is designed and constructed for the purpose of measuring the mechanical properties of single fibers. The instrument is intended to provide high throughput measurement of single fiber geometric ...
Kristofek, Grant William, 1980-
E-Print Network 3.0 - alphascreen high-throughput assay Sample...
Session Chair: James F. Leary 3:20-4:05 James F. Leary, "High throughput cell analysis... French and Jiyan Chen Long Lifetime Measurements in High ... Source: Xu, X. Nancy -...
High-Throughput, High-Precision Hot Testing Tool for High-Brightness...
Energy Savers [EERE]
Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting Diode Testing High-Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting...
A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a
A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a Manjunath Hegde of biofilm community formation. Here, we describe the development of a PDMS-based two-layer microfluidic flow
Wood, Thomas K.
Cell bioprinting as a potential high-throughput method for fabricating cell-based biosensors (CBBs)
Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...
Xu, F.
Microelectroporation device for genomic screening
We have developed an microelectroporation device that combines microarrays of oligonucleotides, microfluidic channels, and electroporation for cell transfection and high-throughput screening applications (e.g. RNA interference screens). Microarrays allow the deposition of thousands of different oligonucleotides in microscopic spots. Microfluidic channels and microwells enable efficient loading of cells into the device and prevent cross-contamination between different oligonucleotides spots. Electroporation allows optimal transfection of nucleic acids into cells (especially hard-to-transfect cells such as primary cells) by minimizing cell death while maximizing transfection efficiency. This invention has the advantage of a higher throughput and lower cost, while preventing cross-contamination compared to conventional screening technologies. Moreover, this device does not require bulky robotic liquid handling equipment and is inherently safer given that it is a closed system.
Perroud, Thomas D.; Renzi, Ronald F.; Negrete, Oscar; Claudnic, Mark R.
Miniaturized Analytical Platforms From Nanoparticle Components: Studies in the Construction, Characterization, and High-Throughput Usage of These Novel Architectures
The scientific community has recently experienced an overall effort to reduce the physical size of many experimental components to the nanometer size range. This size is unique as the characteristics of this regime involve aspects of pure physics, biology, and chemistry. One extensively studied example of a nanometer sized experimental component, which acts as a junction between these three principle scientific theologies, is deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). These biopolymers not only contain the biological genetic guide to code for the production of life-sustaining materials, but are also being probed by physicists as a means to create electrical circuits and furthermore as controllable architectural and sensor motifs in the chemical disciplines. Possibly the most common nano-sized component between these sciences are nanoparticles composed of a variety of materials. The cross discipline employment of nanoparticles is evident from the vast amount of literature that has been produced from each of the individual communities within the last decade. Along these cross-discipline lines, this dissertation examines the use of several different types of nanoparticles with a wide array of surface chemistries to understand their adsorption properties and to construct unique miniaturized analytical and immunoassay platforms. This introduction will act as a literature review to provide key information regarding the synthesis and surface chemistries of several types of nanoparticles. This material will set the stage for a discussion of assembling ordered arrays of nanoparticles into functional platforms, architectures, and sensors. The introduction will also include a short explanation of the atomic force microscope that is used throughout the thesis to characterize the nanoparticle-based structures. Following the Introduction, four research chapters are presented as separate manuscripts. Chapter 1 examines the self-assembly of polymeric nanoparticles exhibiting a variety of surface chemistries and attempts to deconvolute general adsorption rules for their assembly on various substrates. Chapter 2 extends the usage of self-assembly of polymeric nanoparticles through a layer-by-layer deposition concept and photolithography methodologies to create analytical platforms with a vertical height controlled within the nanometer regime. This platform is then furthered in Chapter 3 by employing this integrated concept as a bio-recognition platform, with the extension of the method to a high-throughput screening system explored. Chapter 4 exploits two different types of nanoparticles, silica and gold, as multiplexed, self-assembled immunoassay sensors. This final research chapter is followed by a general summation and future prospectus section that concludes the dissertation.
Andrew David Pris
A search model for topological insulators with high-throughput robustness descriptors
Topological insulators (TI) are becoming one of the most studied classes of novel materials because of their great potential for applications ranging from spintronics to quantum computers. To fully integrate TI materials in electronic devices, high-quality epitaxial single-crystalline phases with sufficiently large bulk bandgaps are necessary. Current efforts have relied mostly on costly and time-consuming trial-and-error procedures. Here we show that by defining a reliable and accessible descriptor {cflx X}TI, which represents the topological robustness or feasibility of the candidate, and by searching the quantum materials repository aflowlib.org, we have automatically discovered 28 TIs (some of them already known) in five different symmetry families. These include peculiar ternary halides, Cs{l_brace}Sn,Pb,Ge{r_brace}{l_brace}Cl,Br,I{r_brace}{sub 3}, which could have been hardly anticipated without high-throughput means. Our search model, by relying on the significance of repositories in materials development, opens new avenues for the discovery of more TIs in different and unexplored classes of systems.
Yang, Kesong; Setyawan, Wahyu; Wang, Shidong; Nardelli, Marco B.; Curtarolo, Stephano
A microreactor array for spatially resolved measurement of catalytic activity for high-throughput catalysis science
We describe a 100 channel microreactor array capable of spatially resolved measurement of catalytic activity across the surface of a flat substrate. When used in conjunction with a composition spread alloy film (CSAF, e.g. Pd{sub x}Cu{sub y}Au{sub 1-x-y}) across which component concentrations vary smoothly, such measurements permit high-throughput analysis of catalytic activity and selectivity as a function of catalyst composition. In the reported implementation, the system achieves spatial resolution of 1 mm{sup 2} over a 10�10 mm{sup 2} area. During operation, the reactant gases are delivered at constant flow rate to 100 points of differing composition on the CSAF surface by means of a 100-channel microfluidic device. After coming into contact with the CSAF catalyst surface, the product gas mixture from each of the 100 points is withdrawn separately through a set of 100 isolated channels for analysis using a mass spectrometer. We demonstrate the operation of the device on a Pd{sub x}Cu{sub y}Au{sub 1-x-y} CSAF catalyzing the H{sub 2}-D{sub 2} exchange reaction at 333 K. In essentially a single experiment, we measured the catalytic activity over a broad swathe of concentrations from the ternary composition space of the Pd{sub x}Cu{sub y}Au{sub 1-x-y} alloy.
Kondratyuk, Petro; Gumuslu, Gamze; Shukla, Shantanu; Miller, James B.; Morreale, Bryan D.; Gellman, Andrew J.
Screening for high-performance piezoelectrics using high-throughput density functional theory
We present a large-scale density functional theory (DFT) investigation of the ABO3 chemical space in the perovskite crystal structure, with the aim of identifying those that are relevant for forming piezoelectric materials. ...
Armiento, Rickard R.
Using Clustering Techniques to Improve Hit Selection in High-Throughput Screening
control. This makes the correct identification of active compounds quite difficult. The incoherencies and Makarenkov,7 and Makarenkov et al.8,9 Another factor that influences the identification of active compounds plate or in the bulk of the data). This method is not statistically justified and can lead to some
Makarenkov, Vladimir
A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae
criteria defined 29 type III proteins from P. syringae pv. tomato, and 19 from P. syringae pv. phaseolicola [disease resistance (R) pro- teins], a battery of host responses is triggered, including localized
Dangl, Jeff
iv v vii ix x xii 3.3.1 Gradient Generation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
A high-throughput in vivo micronucleus assay for genome instability screening in mice
? pH meter (e.g. Meter Toledo MP220) 275 ? Biological safety cabinet (e.g. Fisher Scientific, #12372419) ? Reciprocating shaker (e.g. Stuart SSL2) ? Aluminum foil (e.g. Terinex) ? Single-use 0.22 �m filters (e.g. Corning, #430521) ? 10 ml...
Balmus, Gabriel; Karp, Natasha A; Ng, Bee Ling; Jackson, Stephen P; Adams, David J; McIntyre, Rebecca E
High throughput screen for cells with high extracellular metabolite consumption--secretion rates using microfluidic droplets
Metabolic engineering has contributed significantly to the improvement of strains for the industrial production of various compounds. Traditionally, enzymatic steps closely associated with the product-forming pathway have ...
Wang, Benjamin L. (Benjamin Lu chen)
NSF ITR Project ABSTRACTION HIERARCHY MODELING OF HIGH-THROUGHPUT SCREENING
that are also integrated in the HTS line), this equipment has no proprietary control #12;software. The labeling/configuration" dialogs presented through an assay method programming application/interface used to control the entire AUTOMATION David B.Kaber & Steffen Junginger Overview: This document presents abstraction hierarchy (AH
Kaber, David B.
High-Throughput Computational Screening of thermal conductivity, Debye temperature and Gruneisen parameter
thermal properties such as the Debye temperature and the thermal conductivity of materials. We demonstrate studied for the past few decades6 . Low thermal conductivity mate- rials constitute the basis of a new and predict the thermal conductivity of differ- ent materials8,9,1116 . Such evaluation of the higher
Curtarolo, Stefano
Agenda from the U.S. Department of Energy's High Throughput Screening of
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartment of EnergyAdministrative2|DepartmentDOEHydrogen Storage Materials
Improved Algae-based Biorefining and High-throughput Screening of Algal
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching.348 270 300 219 255 135 1982-2015 East
Quantum-Dot-Based Electrochemical Immunoassay for High-Throughput Screening
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298, and 323 K. |Quantum Field Theory &formats forof
Postdoctoral opportunities are available immediately in a project investigating molecular mechanisms of neurogenic hypertension. We take a systems biology
mechanisms of neurogenic hypertension. We take a systems biology approach involving high-throughput data
Pillow, Jonathan
An apparatus for high throughput muscle cell experimentation
The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...
Garcia-Webb, Michael G. (Michael Gregory)
Treatability studies on different refinery wastewater samples using high-throughput microbial electrolysis cells (MECs)
Treatability studies on different refinery wastewater samples using high-throughput microbial, University Park, PA 16802, USA h i g h l i g h t s Refinery wastewaters were tested as fuels in MECs effective for treatment or pre-treatment of some refinery wastewaters. The best way to start up MECs
ORIGINAL ARTICLE GeoChip 3.0 as a high-throughput tool for analyzing
significantly changed with the plant species diversity. As expected, GeoChip 3.0 is a high-throughput powerful Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA and 8 Virtual Institute Keywords: microarray; functional genes; microbial community; plant diversity Introduction Microorganisms
Hazen, Terry
significantly changed with the plant species diversity. As expected, GeoChip 3.0 is a high-throughput powerful Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA and 8 Virtual Institute in microbial ecology Keywords: microarray; functional genes; microbial community; plant diversity Introduction
Weiblen, George D
High-throughput imaging of heterogeneous cell organelles with an X-ray laser
DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]
Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.
Hantke, Max, F.
A High-Throughput Method to Examine Protein-Nucleotide Interactions Identifies Targets of the Bacterial
A High-Throughput Method to Examine Protein- Nucleotide Interactions Identifies Targets can easily be applied to examine multiple protein-protein, protein-nucleotide and nucleotide-nucleotide Protein-Nucleotide Interactions Identifies Targets of the Bacterial Transcriptional Regulatory Protein Fur
High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo Decoder
High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo paral- lel turbo decoder architectures have been developed. However, the interleaver has become a major that can efficiently solve the memory conflict problem for parallel turbo decoders with very high
High-throughput analysis of thin-film stresses using arrays of micromachined cantilever beams
High-throughput analysis of thin-film stresses using arrays of micromachined cantilever beams Hyun-throughput residual stress measurements on thin films by means of micromachined cantilever beams and an array of parallel laser beams. In this technique, the film of interest is deposited onto a silicon substrate
Determination of Monomethylhydrazine with a High-Throughput, All-Fiber Near-Infrared
Determination of Monomethylhydrazine with a High-Throughput, All-Fiber Near-Infrared Spectrometer-throughput near-infrared spectrophotometer has been successfully constructed by synergistic use of this integrated and wide spectral band- width in the near-infrared region from 1500 to 1600 nm. This spectral region
Reid, Scott A.
Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome
Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome Annotation software on a high performance computing platform such as the grid. The Encyclopedia of Life (EOL) project application to drive grid software development. It is a flagship application for the TeraGrid project [3
HIGH-THROUGHPUT COOPERATIVE TRANSMISSIONS USING ADAPTIVE COMPLEX-FIELD NETWORK CODING Guobing Li1 , Alfonso Cano2 , and Georgios B. Giannakis2 1 School of Elect. and Info. Engr., Xi'an Jiaotong University. In this pa- per, a novel cooperation protocol is developed based on adap- tive complex-field wireless network
Pleite, Alfonso Cano
We developed a new approach to separate bacteria from human blood cells based on soft inertial force induced migration with flow defined curved and focused sample flow inside a microfluidic device. This approach relies on a combination of an asymmetrical sheath flow and proper channel geometry to generate a soft inertial force on the sample fluid in the curved and focused sample flow segment to deflect larger particles away while the smaller ones are kept on or near the original flow streamline. The curved and focused sample flow and inertial effect were visualized and verified using a fluorescent dye primed in the device. First the particle behavior was studied in detail using 9.9 and 1.0 {micro}m particles with a polymer-based prototype. The prototype device is compact with an active size of 3 mm{sup 2}. The soft inertial effect and deflection distance were proportional to the fluid Reynolds number (Re) and particle Reynolds number (Re{sub p}), respectively. We successfully demonstrated separation of bacteria (Escherichia coli) from human red blood cells at high cell concentrations (above 10{sup 8}/mL), using a sample flow rate of up to 18 {micro}L/min. This resulted in at least a 300-fold enrichment of bacteria at a wide range of flow rates with a controlled flow spreading. The separated cells were proven to be viable. Proteins from fractions before and after cell separation were analyzed by gel electrophoresis and staining to verify the removal of red blood cell proteins from the bacterial cell fraction. This novel microfluidic process is robust, reproducible, simple to perform, and has a high throughput compared to other cell sorting systems. Microfluidic systems based on these principles could easily be manufactured for clinical laboratory and biomedical applications.
Wu, Zhigang; Willing, Ben; Bjerketorp, Joakim; Jansson, Janet K.; Hjort, Klas
High-throughput liquid-absorption preconcentrator sampling methods
Zaromb, S.
High-Throughput Mode Liquid Microjunction Surface Sampling Probe
A simple and automated spot sampling operation mode for a liquid microjunction surface sampling probe/electrospray ionization mass spectrometry (LMJ-SSP/ESI-MS) system is reported. Prior manual and automated spot sampling methods with this probe relied on a careful, relatively slow alignment of the probe and surface distance (<20 m spacing) to form the probe-to-surface liquid microjunction critical to successful surface sampling. Moreover, sampling multiple spots required retraction of the surface from the probe and a repeat of this careful probe-to-surface distance alignment at the next sampling position. With the method described here, the probe was not positioned as close to the surface, the exact probeto-surface positioning was found to be less critical (spanning distances from about 100-300 m), and this distance was not altered during the sampling of an entire array of sample spots. With the probe positioned within the appropriate distance from the surface, the liquid microjunction was formed by letting the liquid from the sampling end of the probe extend out from the probe to the surface. This was accomplished by reducing the selfaspiration liquid flow rate of the probe to a value less than the volume flow rate pumped into the probe. When the self-aspiration rate of the probe was subsequently increased, analytes on the surface that dissolved at the liquid microjunction were aspirated back into the probe with the liquid that created the liquid microjunction and electrosprayed. Presented here are the basics of this new sampling mode, as well as data that illustrate the potential analytical capabilities of the device to conduct highthroughput quantitative analysis.
Van Berkel, Gary J [ORNL; Kertesz, Vilmos [ORNL; King, Richard C. [PharmaCadence
Broader source: Energy.gov [DOE]
Screening is typically performed by an outside party or an independent renewable energy expert or team. It is a review of the possible technology options that identifies dead-ends and further...
Screening system and method of using same
An integrated apparatus and method for screening an object for a target material is provided. The integrated apparatus comprises a housing and an integrated screener. The housing is positionable adjacent the object, and has a channel therethrough. The integrated screener is positionable in the housing, and comprises a fan, at least one filter, a heater and an analyzer. The fan is for drawing air carrying particles and vapor through the channel of the housing. The filter(s) is/are positionable in the channel of the housing for passage of the air therethrough. The filter(s) comprise(s) at least one metal foam having a plurality of pores therein for collecting and adsorbing a sample from the particles and vapor passing therethrough. The heater is for applying heat to the at least one metal foam whereby the collected sample is desorbed from the metal foam. The analyzer detects the target material from the desorbed sample.
Jones, David A; Gresham, Christopher A; Basiliere, Marc L; Spates, James J; Rodacy, Philip J
High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)
This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.
Gore, Brooklin [Morgridge Institute for Research] [Morgridge Institute for Research
Evaluation of Tavorite-Structured Cathode Materials for Lithium-Ion Batteries Using High-Throughput Computing
Cathode materials with structure similar to the mineral tavorite have shown promise for use in lithium-ion batteries, but this class of materials is relatively unexplored. We use high-throughput density-functional-theory ...
Mueller, Tim
High-throughput data mined prediction of inorganic compounds and computational discovery of new lithium-ion battery cathode materials
The ability to computationally predict the properties of new materials, even prior to their synthesis, has been made possible due to the current accuracy of modern ab initio techniques. In some cases, high-throughput ...
Hautier, Geoffroy (Geoffroy T. F.)
ScienceCinema (OSTI)
Gore, Brooklin [Morgridge Institute for Research
Advances in high-throughput speed, low-latency communication for embedded instrumentation ( 7th Annual SFAF Meeting, 2012)
Scott Jordan on "Advances in high-throughput speed, low-latency communication for embedded instrumentation" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.
Jordan, Scott [Physik Instrumente
High Throughput Plasmid Sequencing with Illumina and CLC Bio (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)
Ajay Athavale (Monsanto) presents "High Throughput Plasmid Sequencing with Illumina and CLC Bio" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.
Athavale, Ajay [Monsanto
High Throughput Synthesis of Uniform Biocompatible Polymer Beads with High Quantum Dot Loading Using Microfluidic Jet-Mode Breakup
Uniform polymer microbeads with highly loaded quantum dots (QDs) are produced using high-throughput coherent jet breakup of a biocompatible poly(ethylene glycol) diacrylate (PEGDA) prepolymer resin, followed by in-line ...
Lee, Seung-Kon
Infrared-Based Screening System Oak Ridge National Laboratory
Infrared-Based Screening System (IBSS) Oak Ridge National Laboratory managed by UT-Battelle, LLC underperforming or overworking components are identified. These thermal-based systems integrate infrared (IR) sensors or cameras, video images, and vehicle position sensors, and are generically known as infrared
Managing System of Systems Requirements with a Requirements Screening Group
Figuring out an effective and efficient way to manage not only your Requirement�s Baseline, but also the development of all your individual requirements during a Program�s/Project�s Conceptual and Development Life Cycle Stages can be both daunting and difficult. This is especially so when you are dealing with a complex and large System of Systems (SoS) Program with potentially thousands and thousands of Top Level Requirements as well as an equal number of lower level System, Subsystem and Configuration Item requirements that need to be managed. This task is made even more overwhelming when you have to add in integration with multiple requirements� development teams (e.g., Integrated Product Development Teams (IPTs)) and/or numerous System/Subsystem Design Teams. One solution for tackling this difficult activity on a recent large System of Systems Program was to develop and make use of a Requirements Screening Group (RSG). This group is essentially a Team made up of co-chairs from the various Stakeholders with an interest in the Program of record that are enabled and accountable for Requirements Development on the Program/Project. The RSG co-chairs, often with the help of individual support team, work together as a Program Board to monitor, make decisions on, and provide guidance on all Requirements Development activities during the Conceptual and Development Life Cycle Stages of a Program/Project. In addition, the RSG can establish and maintain the Requirements Baseline, monitor and enforce requirements traceability across the entire Program, and work with other elements of the Program/Project to ensure integration and coordination.
Ronald R. Barden
High-throughput, single-worm tracking and analysis in Caenorhabditis elegans
significantly impact worm phenotype. An assessment of the statistical ? indicates that, for popular behavioral features, roughly 10 worms discriminate a mean difference of two standard deviations from wild-type behavior with well over 90% power and, 20 worms... Measu remen ts Enviro nment al Restri ctions Other Benef its Table 2.1: Single-Worm Tracker Comparison High-Throughput, Single-Worm Tracking and Analysis in C. elegans 20 Figure 2.1: WT1 Tracking Hardware A picture of the WT1 hardware...
Yemini, Eviatar
The conventional vibrating machines used in processing plants have had undesirable high noise and vibration levels. They also have had unsatisfactorily low screening efficiency, high energy consumption, high maintenance cost, low productivity, and poor worker safety. These conventional vibrating machines have been used in most every processing plant. Most of the current material separation technology uses heavy and inefficient electric motors with an unbalance rotating mass to generate the shaking. In addition to being excessively noisy, inefficient, high-maintenance, these vibrating machines are often the bottleneck in the entire process. Furthermore, these motors along with the vibrating machines and supporting structure shake other machines and structure in the vicinity. The latter increases maintenance costs while reducing worker health and safety. The conventional vibrating fine screens at taconite processing plants have had the same problems as those listed above. This has resulted in lower screening efficiency, higher energy and maintenance cost, and lower productivity and workers safety concerns. The focus of this work is on the design of a high performance screening machine suitable for taconite processing plants. SmartScreens{trademark} technology uses miniaturized motors, based on smart materials, to generate the shaking. The underlying technologies are Energy Flow Control{trademark} and Vibration Control by Confinement{trademark}. These concepts are used to direct energy flow and confine energy efficiently and effectively to the screen function. The SmartScreens{trademark} technology addresses problems related to noise and vibration, screening efficiency, productivity, and maintenance cost and worker safety. Successful development of SmartScreens{trademark} technology will bring drastic changes to the screening and physical separation industry. The conceptual designs for key components of the SmartScreens{trademark} have been developed. These key components include: smart motors and resonators. It is shown that the smart motors have a good life and performance. The resonators are utilized to amplify motion generated by smart motors. Resonator designs are selected based on the final system requirement and vibration characteristics. In addition, a tabletop demo unit was developed and demonstrated during a conference in 2003. This demo is reviewed in this report. The concept has shown promise and the program is on schedule.
Daryoush Allaei; Asim Syed Mohammed
Development of a high-throughput microfluidic integrated microarray for the detection of chimeric bioweapons.
The advancement of DNA cloning has significantly augmented the potential threat of a focused bioweapon assault, such as a terrorist attack. With current DNA cloning techniques, toxin genes from the most dangerous (but environmentally labile) bacterial or viral organism can now be selected and inserted into robust organism to produce an infinite number of deadly chimeric bioweapons. In order to neutralize such a threat, accurate detection of the expressed toxin genes, rather than classification on strain or genealogical decent of these organisms, is critical. The development of a high-throughput microarray approach will enable the detection of unknowns chimeric bioweapons. The development of a high-throughput microarray approach will enable the detection of unknown bioweapons. We have developed a unique microfluidic approach to capture and concentrate these threat genes (mRNA's) upto a 30 fold concentration. These captured oligonucleotides can then be used to synthesize in situ oligonucleotide copies (cDNA probes) of the captured genes. An integrated microfluidic architecture will enable us to control flows of reagents, perform clean-up steps and finally elute nanoliter volumes of synthesized oligonucleotides probes. The integrated approach has enabled a process where chimeric or conventional bioweapons can rapidly be identified based on their toxic function, rather than being restricted to information that may not identify the critical nature of the threat.
Sheppod, Timothy; Satterfield, Brent; Hukari, Kyle W.; West, Jason A. A.; Hux, Gary A.
Nanoelectrospray ion generation for high-throughput mass spectrometry using a micromachined ultrasonic ejector array
Ultrasonic electrospray ionization (ESI) for high-throughput mass spectrometry is demonstrated using a silicon micromachined microarray. The device uses a micromachined ultrasonic atomizer operating in the 900 kHz-2.5 MHz range for droplet generation and a metal electrode in the fluid cavity for ionization. Since the atomization and ionization processes are separated, the ultrasonic ESI source shows the potential for operation at low voltages with a wide range of solvents in contrast with conventional capillary ESI technology. This is demonstrated using the ultrasonic ESI microarray to obtain the mass spectrum of a 10 {mu}M reserpine sample on a time of flight mass spectrometer with 197:1 signal-to-noise ratio at an ionization potential of 200 V.
Aderogba, S.; Meacham, J.M.; Degertekin, F.L.; Fedorov, A.G.; Fernandez, F.M. [G.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States)
Development and operation of a high-throughput accurate-wavelength lens-based spectrometer
A high-throughput spectrometer for the 400�820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm{sup ?1} grating is matched with fast f/1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy ?0.075 arc sec. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount at the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.
Bell, Ronald E., E-mail: firstname.lastname@example.com [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)
Development and Operation of High-throughput Accurate-wavelength Lens-based Spectrometer
A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.
Bell, Ronald E
Uranium Transport in a High-Throughput Electrorefiner for EBR-II Blanket Fuel
A unique high-throughput Mk-V electrorefiner is being used in the electrometallurgical treatment of the metallic sodium-bonded blanket fuel from the Experimental Breeder Reactor II. Over many cycles, it transports uranium back and forth between the anodic fuel dissolution baskets and the cathode tubes until, because of imperfect adherence of the dendrites, it all ends up in the product collector at the bottom. The transport behavior of uranium in the high-throughput electrorefiner can be understood in terms of the sticking coefficients for uranium adherence to the cathode tubes in the forward direction and to the dissolution baskets in the reverse direction. The sticking coefficients are inferred from the experimental voltage and current traces and are correlated in terms of a single parameter representing the ratio of the cell current to the limiting current at the surface acting as the cathode. The correlations are incorporated into an engineering model that calculates the transport of uranium in the different modes of operation. The model also uses the experimentally derived electrorefiner operating maps that describe the relationship between the cell voltage and the cell current for the three principal transport modes. It is shown that the model correctly simulates the cycle-to-cycle variation of the voltage and current profiles. The model is used to conduct a parametric study of electrorefiner throughput rate as a function of the principal operating parameters. The throughput rate is found to improve with lowering of the basket rotation speed, reduction of UCl{sub 3} concentration in salt, and increasing the maximum cell current or cut-off voltage. Operating conditions are identified that can improve the throughput rate by 60 to 70% over that achieved at present.
Ahluwalia, Rajesh K.; Hua, Thanh Q.; Vaden, DeeEarl [Argonne National Laboratory (United States)
An infrared imaging method for high-throughput combinatorial investigation of hydrogenation-dehydrogenation and new phase
An infrared imaging method for high-throughput combinatorial investigation of hydrogenation Received 9 April 2009; accepted 30 June 2009; published online 30 July 2009 We have developed an infrared imaging setup enabling in situ infrared images to be acquired, and expanded on capabilities of an infrared
Rubloff, Gary W.
PIPA: A High-Throughput Pipeline for Protein Function Annotation Chenggang Yu, Valmik Desai, Nela Zavaljevski, and Jaques Reifman
PIPA: A High-Throughput Pipeline for Protein Function Annotation Chenggang Yu, Valmik Desai, Nela of multisource predictions. We developed Pipeline for Protein Annotation (PIPA), a genome-wide protein function annotation pipeline that runs in a high-performance computing environment. PIPA integrates different tools
PIPELINED PARALLEL ARCHITECTURE FOR HIGH THROUGHPUT MAP DETECTORS Ruwan Ratnayake, Gu-Yeon Wei and Aleksandar Kavcic
PIPELINED PARALLEL ARCHITECTURE FOR HIGH THROUGHPUT MAP DETECTORS Ruwan Ratnayake, Gu-Yeon Wei performance close to the channel capacity limits. Deep pipelined architecture for the forward only method, where as FB-BCJR only allow sequential state metric computations. Parallelism facilitates pipelining, re
Kavcic, Aleksandar
A Cross-Referencing-Based Droplet Manipulation Method for High-Throughput and Pin-Constrained Digital Microfluidic Arrays*
-Constrained Digital Microfluidic Arrays* Tao Xu and Krishnendu Chakrabarty Department of Electrical and Computer Engineering Duke University, Durham, NC 27708, USA {tx, email@example.com Abstract Digital microfluidic. As high-throughput bioassays are mapped to digital microfluidic platforms, the need for design automation
Chakrabarty, Krishnendu
array-based high throughput: Topics by E-print Network
Roehm, Uwe 2009-01-01 13 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...
aureus strains high-throughput: Topics by E-print Network
Roehm, Uwe 2009-01-01 14 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...
antileishmanial high-throughput drug: Topics by E-print Network
Roehm, Uwe 2009-01-01 22 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...
E-Print Network 3.0 - automated high-throughput platform Sample...
more rapidly screen large numbers of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio- Summary: -Riverside (UCR), developed a...
E-Print Network 3.0 - automated high-throughput assay Sample...
more rapidly screen large numbers of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio- Summary: analysts, and can require...
High-Throughput Screening of Mg-Functionalized Metal-Organic Frameworks for Hydrogen Storage near Room Temperature
The hydrogen storage capabilities of 18,383 porous crystalline structures possessing various degrees of Mg functionalization and diverse physical properties were assessed through combined grand canonical Monte Carlo (GCMC) and quantum mechanical...
Col�n, Yamil J.; Fairen-Jimenez, David; Wilmer, Christopher E.; Snurr, Randall Q.
Development of High-Throughput Screens to Target SAM-I Riboswitches (2014 DOE JGI Genomics of Energy & Environment Meeting)
Scott Hickey of the University of California Berkeley speaks at the 9th Annual Genomics of Energy & Environment Meeting on March 20, 2014 in Walnut Creek, Calif.
Hickey, Scott [UC Berkely
The Development of Microfabricated Microbial Fuel Cell Array as a High Throughput Screening Platform for Electrochemically Active Microbes
: Illustration of the 24-well air-cathode MFC array. (1) Anode layer, (2) anode chamber layer, (3) air-cathode layer (PEM/carbon cloth assembly), (4) air-cathode interface. B: Air-cathode interface microfabrication steps. (1) Au/Ti deposited PMMA substrate...
Hou, Huijie
Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes involved in antioxidant defense through binding to Antioxidant Response Elements (ARE) located in the promoter regions...
Wu, Kai Connie; McDonald, Peter R.; Liu, Jie Jerry; Chaguturu, Rathnam; Klaassen, Curtis D.
PHYSICAL REVIEW B 84, 014103 (2011) Screening for high-performance piezoelectrics using high-throughput density functional theory
-throughput density functional theory Rickard Armiento,1 Boris Kozinsky,2 Marco Fornari,3 and Gerbrand Ceder1 1-scale density functional theory (DFT) investigation of the ABO3 chemical space in the perovskite crystal-throughput density functional theory19,20 calculations. The last decades have seen a rapid increase of computational
A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies
treatment for sickle cell disease (SCD) is increased fetal hemoglobin (HbF). Identification of a drug specific for inducing c-globin expression in pediatric and adult patients, with minimal off-target effects, continues to be an elusive goal. One hurdle has..., Kansas, United States of America �c Current address: SRI International, Harrisonburg, Virginia, United States of America Introduction Sickle cell disease (SCD) is the most common monogenetic disease diagnosed in the United States, affecting approximately...
Peterson, Kenneth R.; Costa, Flá via C.; Fedosyuk, Halyna; Neades, Renee Y.; Chazelle, Allen M.; Zelenchuk, Lesya; Fonteles, Andrea H.; Dalal, Parmita; Roy, Anuradha; Chaguturu, Rathnam; Li, Biaoru; Pace, Betty S.
High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons
The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation ...
Nieland, Thomas J.
A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus
-based higsyncytial virus Dong-Hoon Chung1,2, Blake P Moore3,5, Daljit S Matharu4, Jennifer E Golden4, Clinton Maddox3, Lynn Rasmussen3, Melinda I Sosa3, Subramaniam Ananthan3, E Lucile White3, Fuli Jia3,6, Colleen B Jonsson1,2 and William E Severson1* Abstract... syncytial virus. Handbooks in Health Care Co. In Edited by Weisman LE, Groothuis JR. Newtown: PA; 2000:7�23. 18. Hall CB, et al: Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection. a randomized double-blind study. N Engl J...
Chung, Dong-Hoon; Moore, Blake P.; Matharu, Daljit S.; Golden, Jennifer E.; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I.; Ananthan, Subramaniam; White, E. Lucile; Jia, Fuli; Jonsson, Colleen B.; Severson, William E.
PHYSICAL REVIEW B 90, 174107 (2014) High-throughput computational screening of thermal conductivity, Debye temperature, and
for the past few decades [6]. Low thermal conductivity materials constitute the basis of a new generation such as the Debye temperature and the thermal conductivity of materials. We demonstrate that the AGL method, which ranking of the thermal conductivity for several different classes of semiconductor materials
High Throughput Software for Powder Diffraction and its Application to Heterogeneous Catalysis
In this thesis we investigate high throughput computational methods for processing large quantities of data collected from synchrotrons and their application to spectral analysis of powder diffraction data. We also present the main product of this PhD programme, specifically a software called 'EasyDD' developed by the author. This software was created to meet the increasing demand on data processing and analysis capabilities as required by modern detectors which produce huge quantities of data. Modern detectors coupled with the high intensity X-ray sources available at synchrotrons have led to the situation where datasets can be collected in ever shorter time scales and in ever larger numbers. Such large volumes of datasets pose a data processing bottleneck which augments with current and future instrument development. EasyDD has achieved its objectives and made significant contributions to scientific research. It can also be used as a model for more mature attempts in the future. EasyDD is currently in use by a number of researchers in a number of academic and research institutions to process high-energy diffraction data. These include data collected by different techniques such as Energy Dispersive Diffraction, Angle Dispersive Diffraction and Computer Aided Tomography. EasyDD has already been used in a number of published studies, and is currently in use by the High Energy X-Ray Imaging Technology project. The software was also used by the author to process and analyse datasets collected from synchrotron radiation facilities. In this regard, the thesis presents novel scientific research involving the use of EasyDD to handle large diffraction datasets in the study of alumina-supported metal oxide catalyst bodies. These data were collected using Tomographic Energy Dispersive Diffraction Imaging and Computer Aided Tomography techniques.
Taha Sochi
Screening portal, system and method of using same
A portal, system and method for screening an object for a target substance is provided. The portal includes an inflatable bladder expandable to form a test space for receiving the object and a plurality of nozzles positioned about the inflatable bladder. The nozzles are in fluid communication with a fluid source for directing air over the object whereby samples are removed from the object for examination. A collector is operatively connected to the inflatable bladder for collecting the samples removed from the object. A detector is operatively connected to the collector for examining the removed samples for the presence of the target substance. At least one preconcentrator may be operatively connected to the collector for concentrating the samples collected thereby.
Linker, Kevin L.; Hunter, John A.; Brusseau, Charles A.
Integrated crystal mounting and alignment system for high-throughput biological crystallography
A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.
Nordmeyer, Robert A.; Snell, Gyorgy P.; Cornell, Earl W.; Kolbe, William; Yegian, Derek; Earnest, Thomas N.; Jaklevic, Joseph M.; Cork, Carl W.; Santarsiero, Bernard D.; Stevens, Raymond C.
Improving the Yeast Three-Hybrid System for High-Throughput Target Discovery
of the requirements for the degree of Master of Science. ________________________________ Chairperson Dr. Blake R. Peterson ________________________________ Dr. Gary Grunewald ________________________________ Dr.... Gary Grunewald and Dr. Jeff Krise, and my research advisor Dr. Blake Peterson. Additional thanks to Dr. Peterson for guidance, patience, and support over the past years. v TABLE OF CONTENTS ABSTRACT...
Bailey, Kyle
Nordmeyer, Robert A. (San Leandro, CA); Snell, Gyorgy P. (Richmond, CA); Cornell, Earl W. (Antioch, CA); Kolbe, William F. (Moraga, CA); Yegian, Derek T. (Oakland, CA); Earnest, Thomas N. (Berkeley, CA); Jaklevich, Joseph M. (Lafayette, CA); Cork, Carl W. (Walnut Creek, CA); Santarsiero, Bernard D. (Chicago, IL); Stevens, Raymond C. (La Jolla, CA)
Application of High Throughput Pretreatment and Co-Hydrolysis System to Thermochemical
Introduction Sustainable energy sources are needed to supplement petroleum use in light of limited reserves economically, a large number of factors such as feedstock quality, conversion conditions, and catalyst loadings as well as their complex interactions must be better evaluated to identify combina- tions that can
and enzymatic hydrolysis conditions. Although hydrothermal pretreatment is currently being employed in most high were compared to results from hydrothermal pretreatments, providing new insights in understanding their recalcitrance and consolidating processing of enzymes and microorganisms to overcome biomass recalci- trance
Development of a multiplexed microbioreactor system for high-throughput bioprocessing
. However, this is a challenge with current bioreactor technology. The high cost and labor required and fluidic connectors, their sterilization, and disassembly and cleaning. While some fermentation parameters), for example, operates six reactors in parallel, and the ``Fedbatch-Pro'' (DASGIP AG, Germany) includes up
Sinskey, Anthony J.
High-Throughput Genetic Analysis and Combinatorial Chiral Separations Based on Capillary Electrophoresis
Capillary electrophoresis (CE) offers many advantages over conventional analytical methods, such as speed, simplicity, high resolution, low cost, and small sample consumption, especially for the separation of enantiomers. However, chiral method developments still can be time consuming and tedious. They designed a comprehensive enantioseparation protocol employing neutral and sulfated cyclodextrins as chiral selectors for common basic, neutral, and acidic compounds with a 96-capillary array system. By using only four judiciously chosen separation buffers, successful enantioseparations were achieved for 49 out of 54 test compounds spanning a large variety of pKs and structures. Therefore, unknown compounds can be screened in this manner to identify optimal enantioselective conditions in just one rn. In addition to superior separation efficiency for small molecules, CE is also the most powerful technique for DNA separations. Using the same multiplexed capillary system with UV absorption detection, the sequence of a short DNA template can be acquired without any dye-labels. Two internal standards were utilized to adjust the migration time variations among capillaries, so that the four electropherograms for the A, T, C, G Sanger reactions can be aligned and base calling can be completed with a high level of confidence. the CE separation of DNA can be applied to study differential gene expression as well. Combined with pattern recognition techniques, small variations among electropherograms obtained by the separation of cDNA fragments produced from the total RNA samples of different human tissues can be revealed. These variations reflect the differences in total RNA expression among tissues. Thus, this Ce-based approach can serve as an alternative to the DNA array techniques in gene expression analysis.
Wenwan Zhong
New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era (2010 JGI/ANL HPC Workshop)
Cedric Notredame from the Centre for Genomic Regulation gives a presentation on "New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era" at the JGI/Argonne HPC Workshop on January 26, 2010.
Notredame, Cedric [Centre for Genomic Regulation
Definition, Expansion and Screening of Architectures for Planetary Exploration Class Nuclear Electric Propulsion and Power Systems
Nuclear Electric Propulsion and Power Systems By Bryan K. Smith Submitted to the System Design, expansion and screening of Nuclear Electric Propulsion and Power concepts capable of achieving planetaryDefinition, Expansion and Screening of Architectures for Planetary Exploration Class Nuclear
Microfluidic Glycosyl Hydrolase Screening for Biomass-to-Biofuel Conversion
Microfluidic Glycosyl Hydrolase Screening for Biomass-to-Biofuel Conversion Rajiv Bharadwaj such as cellulases and hemicellulases is a limiting and costly step in the conversion of biomass to biofuels strategies. Advances in both areas in turn strongly depend on the progress in developing high- throughput
Singh, Anup
Attendees list from the U.S. Department of Energy's High Throughput
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTie Ltd: Scope Change #1Impacts5)Integration - Strategy andNameScreening
Scheduling screening inspections for replaceable and non-replaceable systems
. For instance, the American Cancer Society recommends three tests to detect signs of breast cancer: mammography, clinical breast exam and breast self-examination. Additionally, the American Medical Womens Association recommends annual mammography and clin- ical... cancer. For instance, mammography?s ability to detect a breast cancer when it is already started is estimated to 77.6% in (Houssami, Ciatto, Irwig, Simpson and Macaskill, 2002). Therefore, when designing screening inspection schedules, the fallibility...
Aral, Bahadir
Six-flow operations for catalyst development in Fischer-Tropsch synthesis: Bridging the gap between high-throughput experimentation and extensive product evaluation
Design and operation of a �six-flow fixed-bed microreactor� setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controllers, assuring an identical isothermal zone of at least 10 cm along six fixed-bed microreactor inserts (4?mm inner diameter). Such a lab-scale setup allows running six experiments in parallel, under equal feed composition, reaction temperature, and conditions of separation and analysis equipment. It permits separate collection of wax and liquid samples (from each flow line), allowing operation with high productivities of C5+ hydrocarbons. The latter is crucial for a complete understanding of FTS product compositions and will represent an advantage over high-throughput setups with more than ten flows where such instrumental considerations lead to elevated equipment volume, cost, and operation complexity. The identical performance (of the six flows) under similar reaction conditions was assured by testing a same catalyst batch, loaded in all microreactors.
Sartipi, Sina, E-mail: firstname.lastname@example.com, E-mail: email@example.com; Jansma, Harrie; Bosma, Duco; Boshuizen, Bart; Makkee, Michiel; Gascon, Jorge, E-mail: email@example.com, E-mail: firstname.lastname@example.com; Kapteijn, Freek [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)] [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)
Determination of gene expression patterns using high-throughput RNA in situ hybridizaion to whole-mount Drosophila embryos
We describe a high-throughput protocol for RNA in situ hybridization (ISH) to Drosophila embryos in a 96-well format. cDNA or genomic DNA templates are amplified by PCR and then digoxigenin-labeled ribonucleotides are incorporated into antisense RNA probes by in vitro transcription. The quality of each probe is evaluated before ISH using a RNA probe quantification (dot blot) assay. RNA probes are hybridized to fixed, mixed-staged Drosophila embryos in 96-well plates. The resulting stained embryos can be examined and photographed immediately or stored at 4oC for later analysis. Starting with fixed, staged embryos, the protocol takes 6 d from probe template production through hybridization. Preparation of fixed embryos requires a minimum of 2 weeks to collect embryos representing all stages. The method has been used to determine the expression patterns of over 6,000 genes throughout embryogenesis.
Weiszmann, R.; Hammonds, A.S.; Celniker, S.E.
High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics
Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: � A novel computational framework was developed for mechanistic study of SADRs. � Off-targets of drugs were identified in large scale and in a high-throughput manner. � SADRs like cardiac disorders were systematically explored in molecular networks. � A number of ADR-associated proteins were identified.
Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: firstname.lastname@example.com [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)
High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury
Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical library of mitochondrial toxicants, and no reliable methods for predicting mitochondrial toxicity. We hypothesized that discrete toxicophores defined by distinct chemical entities can identify previously unidentified mitochondrial toxicants. We used a respirometric assay to screen 1760 compounds (5 ?M) from the LOPAC and ChemBridge DIVERSet libraries. Thirty-one of the assayed compounds decreased uncoupled respiration, a stress test for mitochondrial dysfunction, prior to a decrease in cell viability and reduced the oxygen consumption rate in isolated mitochondria. The mitochondrial toxicants were grouped by chemical similarity and two clusters containing four compounds each were identified. Cheminformatic analysis of one of the clusters identified previously uncharacterized mitochondrial toxicants from the ChemBridge DIVERSet. This approach will enable the identification of mitochondrial toxicants and advance the prediction of mitochondrial toxicity for both drug discovery and risk assessment. - Highlights: � Respirometric assay conducted in RPTC to create mitochondrial toxicant database. � Chemically similar mitochondrial toxicants aligned as mitochondrial toxicophores � Mitochondrial toxicophore identifies five novel mitochondrial toxicants.
Wills, Lauren P. [MitoHealth Inc., Charleston, SC 29403 (United States); Beeson, Gyda C.; Trager, Richard E.; Lindsey, Christopher C. [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Beeson, Craig C. [MitoHealth Inc., Charleston, SC 29403 (United States); Peterson, Yuri K. [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Schnellmann, Rick G., E-mail: email@example.com [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Ralph H. Johnson VA Medical Center, Charleston, SC 29401 (United States)
E-Print Network 3.0 - automated high-throughput cultivations...
and assay system... that within the next 5-10 years miniaturized and automated microfluidicsnanotech platforms that ... Source: Kjellstrm, Hedvig - School of Computer...
Pathway-centric approaches to the analysis of high-throughput genomics data.
??In the last decade, molecular biology has expanded from a reductionist view to a systems-wide view that tries to unravel the complex interactions of cellular� (more)
H�nzelmann, Sonja, 1981-
A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using He+ 30.4nm
A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using Entrance slit farm with ~ 1000 slits Photon counting imager Concave grating used near normal incidence >> Need a higher throughput diffuse EUV spectrometer solar wind respond to coronal
California at Berkeley, University of
Exploring Flexible Strategies in Engineering Systems Using Screening Models Applications to Offshore Petroleum Projects
to Offshore Petroleum Projects by Jijun Lin B.E., Mechanical Engineering, Beijing University of Aeronautics Flexible Strategies in Engineering Systems Using Screening Models Applications to Offshore Petroleum, such as offshore petroleum exploration and production systems, generally require a significant amount of capital
de Weck, Olivier L.
Screening for Real Options �In� an Engineering System: A Step Towards Flexible System Development
The goal of this research is to develop an analytical framework for screening for real options �in� an
Bartolomei, Jason E.
On-the-fly machine-learning for high-throughput experiments: search for rare-earth-free permanent magnets
Advanced materials characterization techniques with ever-growing data acquisition speed and storage capabilities represent a challenge in modern materials science, and new procedures to quickly assess and analyze the data are needed. Machine learning approaches are effective in reducing the complexity of data and rapidly homing in on the underlying trend in multi-dimensional data. Here, we show that by employing an algorithm called the mean shift theory to a large amount of diffraction data in high-throughput experimentation, one can streamline the process of delineating the structural evolution across compositional variations mapped on combinatorial libraries with minimal computational cost. Data collected at a synchrotron beamline are analyzed on the fly, and by integrating experimental data with the inorganic crystal structure database (ICSD), we can substantially enhance the accuracy in classifying the structural phases across ternary phase spaces. We have used this approach to identify a novel magnetic phase with enhanced magnetic anisotropy which is a candidate for rare-earth free permanent magnet.
Kusne, Aaron Gilad [University of Maryland; Gao, Tieren [University of Maryland; Mehta, Apurva [SLAC National Accelerator Laboratory; Ke, Liqin [Ames Laboratory; Nguyen, Manh Cuong [Ames Laboratory; Ho, Kai-Ming [Ames Laboratory; Antropov, Vladimir [Ames Laboratory; Wang, Cai-Zhuang [Ames Laboratory; Kramer, Matthew J [Ames Laboratory; Long, Christian [University of Maryland; Takeuchi, Ichiro [University of Maryland
Systems level characterizations of single and combination drug mechanisms of action in vitro and in vivo
Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical ...
Pritchard, Justin (Justin Robert)
In vivo robotics: the automation of neuroscience and other intact-system biological fields
Robotic and automation technologies have played a huge role in in vitro biological science, having proved critical for scientific endeavors such as genome sequencing and high-throughput screening. Robotic and automation ...
Forest, Craig R.
Assessment of advanced coal-gasification processes. [AVCO high throughput gasification in process; Bell High Mass Flux process; CS-R process; and Exxon Gasification process
This report represents a technical assessment of the following advanced coal gasification processes: AVCO High Throughput Gasification (HTG) Process, Bell Single - Stage High Mass Flux (HMF) Process, Cities Service/Rockwell (CS/R) Hydrogasification Process, and the Exxon Catalytic Coal Gasification (CCG) Process. Each process is evaluated for its potential to produce SNG from a bituminous coal. In addition to identifying the new technology these processes represent, key similarities/differences, strengths/weaknesses, and potential improvements to each process are identified. The AVCO HTG and the Bell HMF gasifiers share similarities with respect to: short residence time (SRT), high throughput rate, slagging and syngas as the initial raw product gas. The CS/R Hydrogasifier is also SRT but is non-slagging and produces a raw gas high in methane content. The Exxon CCG gasifier is a long residence time, catalytic fluidbed reactor producing all of the raw product methane in the gasifier.
McCarthy, J.; Ferrall, J.; Charng, T.; Houseman, J.
High-throughput system can analyze thousands of poplar, maize, and switch grass samples at a time to help determine
to help determine which biomass feedstocks are best suited for biofuels. Researchers at the National
Apparatus for combinatorial screening of electrochemical materials
A high throughput combinatorial screening method and apparatus for the evaluation of electrochemical materials using a single voltage source (2) is disclosed wherein temperature changes arising from the application of an electrical load to a cell array (1) are used to evaluate the relative electrochemical efficiency of the materials comprising the array. The apparatus may include an array of electrochemical cells (1) that are connected to each other in parallel or in series, an electronic load (2) for applying a voltage or current to the electrochemical cells (1), and a device (3), external to the cells, for monitoring the relative temperature of each cell when the load is applied.
Comparative performance of modern digital mammography systems in a large breast screening program
Purpose: To compare physical measures pertaining to image quality among digital mammography systems utilized in a large breast screening program. To examine qualitatively differences in these measures and differences in clinical cancer detection rates between CR and DR among sites within that program. Methods: As part of the routine quality assurance program for screening, field measurements are made of several variables considered to correlate with the diagnostic quality of medical images including: modulation transfer function, noise equivalent quanta, d? (an index of lesion detectability) and air kerma to allow estimation of mean glandular dose. In addition, images of the mammography accreditation phantom are evaluated. Results: It was found that overall there were marked differences between the performance measures of DR and CR mammography systems. In particular, the modulation transfer functions obtained with the DR systems were found to be higher, even for larger detector element sizes. Similarly, the noise equivalent quanta, d?, and the phantom scores were higher, while the failure rates associated with low signal-to-noise ratio and high dose were lower with DR. These results were consistent with previous findings in the authors� program that the breast cancer detection rates at sites employing CR technology were, on average, 30.6% lower than those that used DR mammography. Conclusions: While the clinical study was not large enough to allow a statistically powered system-by-system assessment of cancer detection accuracy, the physical measures expressing spatial resolution, and signal-to-noise ratio are consistent with the published finding that sites employing CR systems had lower cancer detection rates than those using DR systems for screening mammography.
Yaffe, Martin J., E-mail: firstname.lastname@example.com; Bloomquist, Aili K.; Hunter, David M.; Mawdsley, Gordon E. [Physical Sciences Division, Sunnybrook Research Institute, Departments of Medical Biophysics and Medical Imaging, University of Toronto, Ontario M4N 3M5 (Canada)] [Physical Sciences Division, Sunnybrook Research Institute, Departments of Medical Biophysics and Medical Imaging, University of Toronto, Ontario M4N 3M5 (Canada); Chiarelli, Anna M. [Prevention and Cancer Control, Cancer Care Ontario, Dalla Lana School of Public Health, University of Toronto, Ontario M4N 3M5, Canada and Ontario Breast Screening Program, Cancer Care Ontario, Toronto, Ontario M5G 1X3 (Canada)] [Prevention and Cancer Control, Cancer Care Ontario, Dalla Lana School of Public Health, University of Toronto, Ontario M4N 3M5, Canada and Ontario Breast Screening Program, Cancer Care Ontario, Toronto, Ontario M5G 1X3 (Canada); Muradali, Derek [Ontario Breast Screening Program, Cancer Care Ontario, Toronto, Ontario M5G 1X3 (Canada)] [Ontario Breast Screening Program, Cancer Care Ontario, Toronto, Ontario M5G 1X3 (Canada); Mainprize, James G. [Physical Sciences Division, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5 (Canada)] [Physical Sciences Division, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5 (Canada)
Combinatorial Chemistry & High Throughput Screening, 2007, 10, 111-119 111 1386-2073/07 $50.00+.00 2007 Bentham Science Publishers Ltd.
chemicals and intermediates [1]. For example, propylene can be converted into acrolein and acrylic acid carbons are weaker, propylene readily is oxidized to acrolein and to acrylic acid rather than
Genome-Wide High-Throughput Screening to Investigate Essential Genes Involved in Methicillin-Resistant Staphylococcus aureus Sequence Type 398 Survival
) [21] and S. aureus RN4220 were grown in Brain Heart Infusion (BHI) (Oxoid, Difco) broth at 37uC with aeration. S. aureus SH1000 pMARGH2b, S. aureus SH1000 pFA545 and S. aureus RN4220 pFA545gen were grown in BHI or Tryptic Soy Broth (TSB) (Oxoid) with 5...
Christiansen, Mette T.; Kaas, Rolf S.; Chaudhuri, Roy R.; Holmes, Mark A.; Hasman, Henrik; Aarestrup, Frank M.
Advances in High-Throughput Screening for Drug Discovery The UIC Center for Clinical and Translational Science is sponsoring a translational technology symposium on
the Harvard/MIT Broad Institute, Sam Michael, from the NIH Chemical Genomics Center, Annie Mak, from the Genomics Institute of the Novartis Research Foundation, and Marcie Glicksman, from the Harvard Neuro-Scanning-Coupled Microscopy Sam Michael, Group Leader, Automation and Compound Management, NIH Chemical Genomics Center 11
Illinois at Chicago, University of
Use of Time-Aggregated Data in Economic Screening Analyses of Combined Heat and Power Systems
Combined heat and power (CHP) projects (also known as cogeneration projects) usually undergo a series of assessments and viability checks before any commitment is made. A screening analysis, with electrical and thermal loads characterized on an annual basis, may be performed initially to quickly determine the economic viability of the proposed project. Screening analyses using time-aggregated data do not reflect several critical cost influences, however. Seasonal and diurnal variations in electrical and thermal loads, as well as time-of-use utility pricing structures, can have a dramatic impact on the economics. A more accurate economic assessment requires additional detailed data on electrical and thermal demand (e.g., hourly load data), which may not be readily available for the specific facility under study. Recent developments in CHP evaluation tools, however, can generate the needed hourly data through the use of historical data libraries and building simulation. This article utilizes model-generated hourly load data for four potential CHP applications and compares the calculated cost savings of a CHP system when evaluated on a time-aggregated (i.e., annual) basis to the savings when evaluated on an hour-by-hour basis. It is observed that the simple, aggregated analysis forecasts much greater savings (i.e., greater economic viability) than the more detailed hourly analysis. The findings confirm that the simpler tool produces results with a much more optimistic outlook, which, if taken by itself, might lead to erroneous project decisions. The more rigorous approach, being more reflective of actual requirements and conditions, presents a more accurate economic comparison of the alternatives, which, in turn, leads to better decision risk management.
Hudson II, Carl Randy [ORNL
'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care
the system of governance also serves other, more institutional purposes. The prospect of internet-based marketing corporations using access to research data and to electronic health records as an op- portunity to market more products seems both manipu- lative...
Clarke, Angus J; Cooper, David N; Krawczak, Michael; Tyler-Smith, Chris; Wallace, Helen M; Wilkie, Andrew O M; Raymond, Frances L; Chadwick, Ruth; Craddock, Nick; John, Ros; Gallacher, John; Chiano, Mathias
High-throughput on-chip in vivo neural regeneration studies usingfemtosecond laser nano-surgery and microfluidics
In recent years, the advantages of using small invertebrate animals as model systems for human disease have become increasingly apparent and have resulted in three Nobel Prizes in medicine or chemistry during the last six ...
Samara, Chrysanthi
Development of a semi-automated ZLC system for rapid screening of adsorbents for carbon capture�
In this dissertation a novel ZLC setup has been developed as part of a DOE-funded grant in collaboration with UOP, to provide rapid screening of novel adsorbent materials for carbon capture (CC). The key features of the ...
Hu, Xiayi
High throughput reproducible cantilever functionalization
A method for functionalizing cantilevers is provided that includes providing a holder having a plurality of channels each having a width for accepting a cantilever probe and a plurality of probes. A plurality of cantilever probes are fastened to the plurality of channels of the holder by the spring clips. The wells of a well plate are filled with a functionalization solution, wherein adjacent wells in the well plate are separated by a dimension that is substantially equal to a dimension separating adjacent channels of the plurality of channels. Each cantilever probe that is fastened within the plurality of channels of the holder is applied to the functionalization solution that is contained in the wells of the well plate.
Evans, Barbara R; Lee, Ida
High-Throughput Plasmonic Nanolithography
by a thin layer of Perfluoropolyether (PFPE) as a lubricant2-nm thick lubricant Perfluoropolyether (PFPE) was also dip-
Pan, Liang
Engineering task plan for the development of a high pressure water drill system for BY-105 saltwell screen installation
This engineering task plan identifies the activities required for developing an ultra high pressure water drill system for installation of a saltwell screen in Tank BY-105. A water drill system is needed to bore through the hard waste material in this tank because of the addition of Portland cement in the 1960s and/or 1970s. The activities identified in this plan include the design, procurement, and qualification testing of the water drill along with readiness preparations including developing operating procedures, training Operations personnel, and conducting an assessment of readiness.
Plant Phenotype Characterization System
This report is the final scientific report for the DOE Inventions and Innovations Project: Plant Phenotype Characterization System, DE-FG36-04GO14334. The period of performance was September 30, 2004 through July 15, 2005. The project objective is to demonstrate the viability of a new scientific instrument concept for the study of plant root systems. The root systems of plants are thought to be important in plant yield and thus important to DOE goals in renewable energy sources. The scientific study and understanding of plant root systems is hampered by the difficulty in observing root activity and the inadequacy of existing root study instrumentation options. We have demonstrated a high throughput, non-invasive, high resolution technique for visualizing plant root systems in-situ. Our approach is based upon low-energy x-ray radiography and the use of containers and substrates (artificial soil) which are virtually transparent to x-rays. The system allows us to germinate and grow plant specimens in our containers and substrates and to generate x-ray images of the developing root system over time. The same plant can be imaged at different times in its development. The system can be used for root studies in plant physiology, plant morphology, plant breeding, plant functional genomics and plant genotype screening.
Daniel W McDonald; Ronald B Michaels
Development & Optimization of Materials and Processes for a Cost Effective Photoelectrochemical Hydrogen Production System. Final report
The overall project objective was to apply high throughput experimentation and combinatorial methods together with novel syntheses to discover and optimize efficient, practical, and economically sustainable materials for photoelectrochemical production of bulk hydrogen from water. Automated electrochemical synthesis and photoelectrochemical screening systems were designed and constructed and used to study a variety of new photoelectrocatalytic materials. We evaluated photocatalytic performance in the dark and under illumination with or without applied bias in a high-throughput manner and did detailed evaluation on many materials. Significant attention was given to ?-Fe2O3 based semiconductor materials and thin films with different dopants were synthesized by co-electrodeposition techniques. Approximately 30 dopants including Al, Zn, Cu, Ni, Co, Cr, Mo, Ti, Pt, etc. were investigated. Hematite thin films doped with Al, Ti, Pt, Cr, and Mo exhibited significant improvements in efficiency for photoelectrochemical water splitting compared with undoped hematite. In several cases we collaborated with theorists who used density functional theory to help explain performance trends and suggest new materials. The best materials were investigated in detail by X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet-visual spectroscopy (UV-Vis), X-ray photoelectron spectroscopy (XPS). The photoelectrocatalytic performance of the thin films was evaluated and their incident photon
McFarland, Eric W
From screen to structure with a harvestable microfluidic device
Advances in automation have facilitated the widespread adoption of high-throughput vapor-diffusion methods for initial crystallization screening. However, for many proteins, screening thousands of crystallization conditions fails to yield crystals of sufficient quality for structural characterization. Here, the rates of crystal identification for thaumatin, catalase and myoglobin using microfluidic Crystal Former devices and sitting-drop vapour-diffusion plates are compared. It is shown that the Crystal Former results in a greater number of identified initial crystallization conditions compared with vapor diffusion. Furthermore, crystals of thaumatin and lysozyme obtained in the Crystal Former were used directly for structure determination both in situ and upon harvesting and cryocooling. On the basis of these results, a crystallization strategy is proposed that uses multiple methods with distinct kinetic trajectories through the protein phase diagram to increase the output of crystallization pipelines.
Stojanoff V.; Jakonic, J.; Oren, D.A.; Nagarajan, V.; Navarro Poulsen, J.C.; Adams-Cioaba, M.A.; Bergfors, T. and Sommer, M.O.A.
Verifying Distributed Real-time Properties of Embedded Systems via Graph Transformations and Model Checking
S properties, such as low latency, low energy consumption, bounded jitter, high reliability, high throughput and data acquisition (SCADA) systems that manage regional power grids. Key un- resolved challenges include
Abdelwahed, Sherif
A screening model to explore planning decisions in automotive manufacturing systems under demand uncertainty
Large-scale, complex engineering systems, as for automotive manufacturing, often require significant capital investment and resources for systems configuration. Furthermore, these systems operate in environments that are ...
Yang, Yingxia
Preliminary Screening
The first step in assessing renewable energy options is to conduct a preliminary screening to decide which technologies are worth investigating and which can be eliminated immediately. Preliminary...
Screening Analysis for the Environmental Risk Evaluation System Fiscal Year 2011 Report Environmental Effects of Offshore Wind Energy
Potential environmental effects of offshore wind (OSW) energy development are not well understood, and yet regulatory agencies are required to make decisions in spite of substantial uncertainty about environmental impacts and their long-term consequences. An understanding of risks associated with interactions between OSW installations and avian and aquatic receptors, including animals, habitats, and ecosystems, can help define key uncertainties and focus regulatory actions and scientific studies on interactions of most concern. During FY 2011, Pacific Northwest National Laboratory (PNNL) scientists adapted and applied the Environmental Risk Evaluation System (ERES), first developed to examine the effects of marine and hydrokinetic energy devices on aquatic environments, to offshore wind development. PNNL scientists conducted a risk screening analysis on two initial OSW cases: a wind project in Lake Erie and a wind project off the Atlantic coast of the United States near Atlantic City, New Jersey. The screening analysis revealed that top-tier stressors in the two OSW cases were the dynamic effects of the device (e.g., strike), accidents/disasters, and effects of the static physical presence of the device, such as alterations in bottom habitats. Receptor interactions with these stressors at the highest tiers of risk were dominated by threatened and endangered animals. Risk to the physical environment from changes in flow regime also ranked high. Peer review of this process and results will be conducted during FY 2012. The ERES screening analysis provides an assessment of the vulnerability of environmental receptors to stressors associated with OSW installations; a probability analysis is needed to determine specific risk levels to receptors. As more data become available that document effects of offshore wind farms on specific receptors in U.S. coastal and Great Lakes waters, probability analyses will be performed.
Copping, Andrea E.; Hanna, Luke A.
Exploring flexible strategies in engineering systems using screening models : applications to offshore petroleum projects
Engineering Systems, such as offshore petroleum exploration and production systems, generally require a significant amount of capital investment under various technical and market uncertainties. Choosing appropriate designs ...
Lin, Jijun, Ph. D. Massachusetts Institute of Technology
Objective: Determine the energy use of two greenhouse insulation technologies (a bubble insulation system and an energy/shade screen) retrofitted into plastic covered greenhouses, and compare the
compared to the unimproved house. The bubble insulation system was more energy efficient than the other two roughly twice the savings stated above. Novel Approaches to Improve Energy Efficiency in Northern New system and an energy/shade screen) retrofitted into plastic covered greenhouses, and compare
Vermont, University of
Usability Heuristics and Qualitative Indicators for the Usability Evaluation of Touch Screen Ventilator Systems
system provides respiratory support to critically ill patients in the Intensive Care Unit. Increasing, multi-parameter monitoring system, defibrillator, ECG analyzer, etc. Mechanical age medical equipments evaluation. A ventilator system gives respiratory support to critically ill patients [5]. Ventilators can
Boyer, Edmond
A Screening Model to Explore Planning Decisions in Automotive Manufacturing Systems under Demand Uncertainty
of Philosophy IN ENGINEERING SYSTEMS At the MASSACHUSETTS INSTITUTE OF TECHNOLOGY © 2009 Massachusetts of the Requirement for the Degree of Doctor of Philosophy In Engineering Systems Abstract Largescale, complex linear optimization. The identified solution is then examined with Value at Risk and Gain chart
Screening of mixed surfactant systems: Phase behavior studies and CT imaging of surfactant-enhanced oil recovery experiments
A systematic chemical screening study was conducted on selected anionic-nonionic and nonionic-nonionic systems. The objective of the study was to evaluate and determine combinations of these surfactants that would exhibit favorable phase behavior and solubilization capacity. The effects of different parameters including (a) salinity, (b) temperature, (c) alkane carbon number, (c) hydrophilic/lipophilic balance (HLB) of nonionic component, and (d) type of surfactant on the behavior of the overall chemical system were evaluated. The current work was conducted using a series of ethoxylated nonionic surfactants in combinations of several anionic systems with various hydrocarbons. Efforts to correlate the behavior of these mixed systems led to the development of several models for the chemical systems tested. The models were used to compare the different systems and provided some guidelines for formulating them to account for variations in salinity, oil hydrocarbon number, and temperature. The models were also evaluated to determine conformance with the results from experimental measurements. The models provided good agreement with experimental results. X-ray computed tomography (CT) was used to study fluid distributions during chemical enhanced oil recovery experiments. CT-monitored corefloods were conducted to examine the effect of changing surfactant slug size injection on oil bank formation and propagation. Reducing surfactant slug size resulted in lower total oil production. Oil recovery results, however, did not correlate with slug size for the low-concentration, alkaline, mixed surfactant system used in these tests. The CT measurements showed that polymer mobility control and core features also affected the overall oil recovery results.
Llave, F.M.; Gall, B.L.; Lorenz, P.B.; Cook, I.M.; Scott, L.J.
Synthesis and Screening of Thin Films in the CeCl3-CeBr3 System...
compositions, crystal structures, and luminescence characteristics. Citation: Matson DW, GL Graff, JL Male, BR Johnson, Z Nie, AG Joly, and LC Olsen.2010."Synthesis and Screening...
System and method for generating and/or screening potential metal-organic frameworks
A system and method for systematically generating potential metal-organic framework (MOFs) structures given an input library of building blocks is provided herein. One or more material properties of the potential MOFs are evaluated using computational simulations. A range of material properties (surface area, pore volume, pore size distribution, powder x-ray diffraction pattern, methane adsorption capability, and the like) can be estimated, and in doing so, illuminate unidentified structure-property relationships that may only have been recognized by taking a global view of MOF structures. In addition to identifying structure-property relationships, this systematic approach to identify the MOFs of interest is used to identify one or more MOFs that may be useful for high pressure methane storage.
Wilmer, Christopher E; Leaf, Michael; Snurr, Randall Q; Farha, Omar K; Hupp, Joseph T
, charts or computer-generated graphics are included. Screens whose main use is to show television or film or PC based environment, e.g. engineering machinery control applications, process control systems etc
Projection screen having reduced ambient light scattering
An apparatus and method for improving the contrast between incident projected light and ambient light reflected from a projection screen are described. The efficiency of the projection screen for reflection of the projected light remains high, while permitting the projection screen to be utilized in a brightly lighted room. Light power requirements from the projection system utilized may be reduced.
Sweatt, William C. (Albuquerque, NM)
Investigating the Operational Capabilities of Custom and Pedestrian Portal Monitoring Systems for Screening Livestock for Radioactive Contamination
radionuclide identification capabilities. An array of six sodium iodide detectors was mounted on a panel and field-tested beside a cattle chute and in a walkway. The custom portal, the Bovine Screening Portal (BSP), observed increased count rates (>10?) from a...
Erchinger, Jennifer
Wafer screening device and methods for wafer screening
Wafer breakage is a serious problem in the photovoltaic industry because a large fraction of wafers (between 5 and 10%) break during solar cell/module fabrication. The major cause of this excessive wafer breakage is that these wafers have residual microcracks--microcracks that were not completely etched. Additional propensity for breakage is caused by texture etching and incomplete edge grinding. To eliminate the cost of processing the wafers that break, it is best to remove them prior to cell fabrication. Some attempts have been made to develop optical techniques to detect microcracks. Unfortunately, it is very difficult to detect microcracks that are embedded within the roughness/texture of the wafers. Furthermore, even if such detection is successful, it is not straightforward to relate them to wafer breakage. We believe that the best way to isolate the wafers with fatal microcracks is to apply a stress to wafers--a stress that mimics the highest stress during cell/module processing. If a wafer survives this stress, it has a high probability of surviving without breakage during cell/module fabrication. Based on this, we have developed a high throughput, noncontact method for applying a predetermined stress to a wafer. The wafers are carried on a belt through a chamber that illuminates the wafer with an intense light of a predetermined intensity distribution that can be varied by changing the power to the light source. As the wafers move under the light source, each wafer undergoes a dynamic temperature profile that produces a preset elastic stress. If this stress exceeds the wafer strength, the wafer will break. The broken wafers are separated early, eliminating cost of processing into cell/module. We will describe details of the system and show comparison of breakage statistics with the breakage on a production line.
Sopori, Bhushan; Rupnowski, Przemyslaw
A high-throughput distributed DNA
of royalty provided that (1) each reproduction is done without alteration and (2) the Journal reference, of this paper may be copied or distributed royalty free without further permission by computer-based and other
Weller, Jennifer Walsh
High-throughput hyperdimensional vertebrate phenotyping
Most gene mutations and biologically active molecules cause complex responses in animals that cannot be predicted by cell culture models. Yet animal studies remain too slow and their analyses are often limited to only a ...
Pardo-Martin, Carlos
High Throughput Single Molecule Investigation of Transcription
Dots. Nano Letters 9, 1598�1603. 4. Ebenstein, Y. , Gassman,Dots. Nano Letters 9, 1598-1603 (2009). Ebenstein, Y. ,
Kim, Soohong
Single Molecule Protein Folding in a Coaxial Mixer. Biophys.Kinetic Studies of Protein Folding. Anal. Chem. 76, 7169-Molecule Measurement of Protein Folding Kinetics . Science
Approaches to High Throughput Physical Organic Chemistry�
compounds, using positive electrospray MS as the sole analytical tool. A version of the construct allowed HT reactivity profiling to be carried out on a range of ten carboxylic acids, ten aldehydes and ten isonitriles in the Ugi 4-component condensation...
Portal, Christophe
Optimal Assembly for High Throughput Shotgun Sequencing
suf- ficient conditions for success in terms of repeat-between the sufficient condition guaranteeing the success ofby a read). Condition (a) K > ? interleaved for success of
Bresler, Guy; Bresler, Ma'ayan; Tse, David
High-throughput proteomics : optical approaches.
Realistic cell models could greatly accelerate our ability to engineer biochemical pathways and the production of valuable organic products, which would be of great use in the development of biofuels, pharmaceuticals, and the crops for the next green revolution. However, this level of engineering will require a great deal more knowledge about the mechanisms of life than is currently available. In particular, we need to understand the interactome (which proteins interact) as it is situated in the three dimensional geometry of the cell (i.e., a situated interactome), and the regulation/dynamics of these interactions. Methods for optical proteomics have become available that allow the monitoring and even disruption/control of interacting proteins in living cells. Here, a range of these methods is reviewed with respect to their role in elucidating the interactome and the relevant spatial localizations. Development of these technologies and their integration into the core competencies of research organizations can position whole institutions and teams of researchers to lead in both the fundamental science and the engineering applications of cellular biology. That leadership could be particularly important with respect to problems of national urgency centered around security, biofuels, and healthcare.
Davidson, George S.
Squires, T. & Quake, S. Microfluidics: Fluid physics at themerged two techniques: microfluidics and single- moleculeassay equipped with microfluidics. Chapter three describes
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Erkitinib, a novel EGFR tyrosine kinase inhibitor screened using a ProteoChip system from a phytochemical library
Receptor tyrosine kinases (PTKs) play key roles in the pathogenesis of numerous human diseases, including cancer. Therefore PTK inhibitors are currently under intensive investigation as potential drug candidates. Herein, we report on a ProteoChip-based screening of an epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitor, Erkitinibs, from phytochemical libraries. PLC-{gamma}-1 was used as a substrate immobilized on a ProteoChip and incubated with an EGFR kinase to phosphorylate tyrosine residues of the substrate, followed by a fluorescence detection of the substrate recognized by a phospho-specific monoclonal antibody. Erkitinibs inhibited HeLa cell proliferation in a dose-dependent manner. In conclusion, these data suggest that Erkitinibs can be a specific inhibitor of an EGFR kinase and can be further developed as a potent anti-tumor agent.
Kim, Eung-Yoon; Choi, Young-Jin [Biochip Research Center, Hoseo University, Asan 336-795 (Korea, Republic of) [Biochip Research Center, Hoseo University, Asan 336-795 (Korea, Republic of); Innopharmascreen, Inc., Asan 336-795 (Korea, Republic of); Park, Chan-Won [Biochip Research Center, Hoseo University, Asan 336-795 (Korea, Republic of) [Biochip Research Center, Hoseo University, Asan 336-795 (Korea, Republic of); Dept. of Biological Science, Hoseo University, Asan 336-795 (Korea, Republic of); Kang, In-Cheol, E-mail: email@example.com [Biochip Research Center, Hoseo University, Asan 336-795 (Korea, Republic of) [Biochip Research Center, Hoseo University, Asan 336-795 (Korea, Republic of); Dept. of Biological Science, Hoseo University, Asan 336-795 (Korea, Republic of); Innopharmascreen, Inc., Asan 336-795 (Korea, Republic of)
Site Screening, Site Selection,
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The BioASP Library: ASP Solutions for Systems Biology
The BioASP Library: ASP Solutions for Systems Biology Martin Gebser, Arne K¨onig, Torsten Schaub--Today's molecular biology is confronted with enor- mous amounts of data, generated by new high-throughput tech- nologies, along with an increasing number of biological models available over web repositories. This poses
Schaub, Torsten
Reverse Ecology: From Systems to Environments and Back
Chapter 15 Reverse Ecology: From Systems to Environments and Back Roie Levy and Elhanan Borenstein the environments in which they evolved and are adapted to. Re- verse Ecology--an emerging new frontier's ecology. The Reverse Ecology framework facilitates the translation of high-throughput genomic data
Borenstein, Elhanan
The purpose of this report is to evaluate and document the screening of the clad degradation features, events, and processes (FEPs) with respect to modeling used to support the Total System Performance Assessment-License Application (TSPA-LA). This report also addresses the effect of certain FEPs on both the cladding and the commercial spent nuclear fuel (CSNF), DOE-owned spent nuclear fuel (DSNF), and defense high-level waste (DHLW) waste forms, as appropriate to address the effects on multiple materials and both components (FEPs 2.1.09.09.0A, 2.1.09.11.0A, 2.1.11.05.0A, 2.1.12.02.0A, and 2.1.12.03.0A). These FEPs are expected to affect the repository performance during the postclosure regulatory period of 10,000 years after permanent closure. Table 1-1 provides the list of cladding FEPs, including their screening decisions (include or exclude). The primary purpose of this report is to identify and document the analysis, screening decision, and TSPA-LA disposition (for included FEPs) or screening argument (for excluded FEPs) for these FEPs related to clad degradation. In some cases, where a FEP covers multiple technical areas and is shared with other FEP reports, this report may provide only a partial technical basis for the screening of the FEP. The full technical basis for shared FEPs is addressed collectively by the sharing FEP reports. The screening decisions and associated TSPA-LA dispositions or screening arguments from all of the FEP reports are cataloged in a project-specific FEPs database.
R. Schreiner
Screening study for evaluation of the potential for system 80+ to consume excess plutonium - Volume 1. Final report
As part of the U.S. effort to evaluate technologies offering solutions for the safe disposal or utilization of surplus nuclear materials, the fiscal year 1993 Energy and Water Appropriations legislation provided the Department of Energy (DOE) the necessary funds to conduct multi-phased studies to determine the technical feasibility of using reactor technologies for the triple mission of burning weapons grade plutonium, producing tritium for the existing smaller weapons stockpile, and generating commercial electricity. DOE limited the studies to five advanced reactor designs. Among the technologies selected is the ABB-Combustion Engineering (ABB-CE) System 80+. The DOE study, currently in Phase ID, is proceeding with a more detailed evaluation of the design`s capability for plutonium disposition.
Not Available
Screening study for evaluation of the potential for system 80+ to consume excess plutonium - Volume 2. Final report
Clad Degradation - FEPs Screening Arguments
The purpose of this report is to document the screening of the cladding degradation features, events, and processes (FEPs) for commercial spent nuclear fuel (CSNF). This report also addresses the effect of some FEPs on both the cladding and the CSNF, DSNF, and HLW waste forms where it was considered appropriate to address the effects on both materials together. This report summarizes the work of others to screen clad degradation FEPs in a manner consistent with, and used in, the Total System Performance Assessment-License Application (TSPA-LA). This document was prepared according to ''Technical Work Plan for Waste Form Degradation Modeling, Testing, and Analyses in Support of LA'' (BSC 2004a [DIRS 167796]).
E. Siegmann
GPU Computational Screening
GPU Computational Screening of Carbon Capture Materials J. Kim 1 , A Koniges 1 , R. Martin 1 , M. Haranczyk 1 , J. Swisher 2 , and B. Smit 1,2 1 Lawrence Berkeley National...
Algorithm for Screening Phasor Measurement Unit Data for Power System Events and Categories and Common Characteristics for Events Seen in Phasor Measurement Unit Relative Phase-Angle Differences and Frequency Signals
A network of multiple phasor measurement units (PMU) was created, set up, and maintained at the University of Texas at Austin to obtain actual power system measurements for power system analysis. Power system analysis in this report covers a variety of time ranges, such as short- term analysis for power system disturbances and their effects on power system behavior and long- term power system behavior using modal analysis. The first objective of this report is to screen the PMU data for events. The second objective of the report is to identify and describe common characteristics extracted from power system events as measured by PMUs. The numerical characteristics for each category and how these characteristics are used to create selection rules for the algorithm are also described. Trends in PMU data related to different levels and fluctuations in wind power output are also examined.
Allen, A.; Santoso, S.; Muljadi, E.
Bose-Einstein Condensation on Holographic Screens
We consider a boson gas on holographic screens of the Rindler and Schwartzschild spacetimes. It is shown that the gas on the stretched horizon is in a Bose-Einstein condensed state with the Hawking temperature $T_c=T_H$ if the particle number of the system be equal to the number of quantum bits of spacetime $ N \\simeq {A}/{{\\l_{p}}^{2}}$. A boson gas on a holographic screen $(r>2M)$ with the same number of particles and at Unruh temperature is also in a condensed state. Far from the horizon, the Unruh temperature is much lower than the condensation temperature $(T_c=T_{{Unruh}}+\\sqrt {f(r)} T_{Planck})$. This analysis implies a possible physical model for quantum bits of spacetime on a holographic screen. We propose a unique and physical interpretation for equipartition theorem on holographic screens. Also, we will argue that this gas is a fast scrambler.
Mirza, Behrouz; Raissi, Zahra
Preliminary Screening Analysis for the Environmental Risk Evaluation System: Task 2.1.1: Evaluating Effects of Stressors � Fiscal Year 2010 Progress Report: Environmental Effects of Marine and Hydrokinetic Energy
Possible environmental effects of marine and hydrokinetic (MHK) energy development are not well understood, and yet regulatory agencies are required to make decisions in spite of substantial uncertainty about environmental impacts and their long-term effects. An understanding of risk associated with likely interactions between MHK installations and aquatic receptors, including animals, habitats, and ecosystems, can help reduce the level of uncertainty and focus regulatory actions and scientific studies on interactions of most concern. As a first step in developing the Pacific Northwest National Laboratory (PNNL) Environmental Risk Evaluation System (ERES), PNNL scientists conducted a preliminary risk screening analysis on three initial MHK cases - a tidal project in Puget Sound using Open Hydro turbines, a wave project off the coast of Oregon using Ocean Power Technologies point attenuator buoys, and a riverine current project in the Mississippi River using Free Flow turbines. Through an iterative process, the screening analysis revealed that top-tier stressors in all three cases were the effects of the dynamic physical presence of the device (e.g., strike), accidents, and effects of the static physical presence of the device (e.g., habitat alteration). Receptor interactions with these stressors at the four highest tiers of risk were dominated by marine mammals (cetaceans and pinnipeds) and birds (diving and non-diving); only the riverine case (Free Flow) included different receptors in the third tier (fish) and the fourth tier (benthic invertebrates). Although this screening analysis provides a preliminary analysis of vulnerability of environmental receptors to stressors associated with MHK installations, probability analysis, especially of risk associated with chemical toxicity and accidents such as oil spills or lost gear, will be necessary to further understand high-priority risks. Subject matter expert review of this process and results is required and is planned for the first quarter of FY11. Once expert review is finalized, the screening analysis phase of ERES will be complete.
Anderson, Richard M.; Copping, Andrea E.; Van Cleve, Frances B.
Hydropower Potential Screening Study
Hydropower Potential Screening Study Gillian Charles GRAC 5/28/14 #12;Latest Hydropower Potential Study Creating a Buzz 2014 DOE study on undeveloped stream reaches 84.7 GW undeveloped hydropower in undeveloped stream reaches hydropower in the PNW #12;Studies at both National
Conventional Medical Screening Program
Medical screening is a strategy used to identify diseases or conditions in a select population at an early stage, often before signs and symptoms develop, and to refer individuals with suspicious findings to their personal physician or a specialist for further testing, diagnosis, and treatment. The program is not intended to serve as a substitute for routine medical exams through an individual's personal physician.
www.emsl.pnnl.gov New Decade, New Tools, New Science: SyStemS biology
, including high-throughput genomics, transcriptomics, proteomics, and metabolomics analyses as well as high
Cosmic Web and Environmental Dependence of Screening: Vainshtein vs. Chameleon
Theories which modify general relativity to explain the accelerated expansion of the Universe often use screening mechanisms to satisfy constraints on Solar System scales. We investigate the effects of the cosmic web and the local environmental density of dark matter halos on the screening properties of the Vainshtein and chameleon screening mechanisms. We compare the cosmic web morphology of dark matter particles, mass functions of dark matter halos, mass and radial dependence of screening, velocity dispersions and peculiar velocities, and environmental dependence of screening mechanisms in $f(R)$ and nDGP models. Using the ORIGAMI cosmic web identification routine we find that the Vainshtein mechanism depends on the cosmic web morphology of dark matter particles, since these are defined according to the dimensionality of their collapse, while the chameleon mechanism shows no morphology dependence. The chameleon screening of halos and their velocity dispersions depend on halo mass, and small halos and subhalos can be environmentally screened in the chameleon mechanism. On the other hand, the screening of halos in the Vainshtein mechanism does not depend on mass nor environment, and their velocity dispersions are suppressed. The peculiar velocities of halos in the Vainshtein mechanism are enhanced because screened objects can still feel the fifth force generated by external fields, while peculiar velocities of chameleon halos are suppressed when the halo centers are screened.
Bridget Falck; Kazuya Koyama; Gong-bo Zhao
Theories which modify general relativity to explain the accelerated expansion of the Universe often use screening mechanisms to satisfy constraints on Solar System scales. We investigate the effects of the cosmic web and the local environmental density of dark matter halos on the screening properties of the Vainshtein and chameleon screening mechanisms. We compare the cosmic web morphology of dark matter particles, mass functions of dark matter halos, mass and radial dependence of screening, velocity dispersions and peculiar velocities, and environmental dependence of screening mechanisms in $f(R)$ and nDGP models. Using the ORIGAMI cosmic web identification routine we find that the Vainshtein mechanism depends on the cosmic web morphology of dark matter particles, since these are defined according to the dimensionality of their collapse, while the chameleon mechanism shows no morphology dependence. The chameleon screening of halos and their velocity dispersions depend on halo mass, and small halos and subhal...
Falck, Bridget; Zhao, Gong-bo
Page 1 of 9 Full Screen
Evolution of Database Systems Graph-Based Relational Object-Relational 1960's-1970's 1980's-1990's 1990's-Oriented programming language with a DBMS 3 One approach is to implement on top of a relational DBMS. · Object #12;Home Page Title Page Page 5 of 9 Go Back Full Screen Close Quit Object-Relational Evolution
Levene, Mark
Can infrared gravitons screen $?$?
It has been suggested that infrared gravitons in de Sitter space may lead to a secular screening of the effective cosmological constant. This seems to clash with the naive expectation that the curvature scalar should stay constant due to the Heisenberg equation of motion. Here, we show that the tadpole correction to the local expansion rate, which has been used in earlier analyses as an indicator of a decaying effective $\\Lambda$, is not gauge invariant. On the other hand, we construct a gauge invariant operator which measures the renormalized curvature scalar smeared over an arbitrary window function, and we find that there is no secular screening of this quantity (to any given order in perturbation theory).
Jaume Garriga; Takahiro Tanaka
Dynamic Screening and Thermonuclear Reaction Rates
We show that there are no dynamic screening corrections to the Salpeter's enhancement factor in the weak-screening limit.
Andrei V. Gruzinov
Screening Analysis for the Environmental Risk Evaluation System Task 126.96.36.199: Evaluating Effects of Stressors Fiscal Year 2011 Progress Report - Environmental Effects of Marine and Hydrokinetic Energy
Potential environmental effects of marine and hydrokinetic (MHK) energy development are not well understood, and yet regulatory agencies are required to make decisions in spite of substantial uncertainty about environmental impacts and their long-term consequences. An understanding of risks associated with interactions between MHK installations and aquatic receptors, including animals, habitats, and ecosystems, can help define key uncertainties and focus regulatory actions and scientific studies on interactions of most concern. As a first step in developing the Pacific Northwest National Laboratory (PNNL) Environmental Risk Evaluation System (ERES), PNNL scientists conducted a preliminary risk screening analysis on three initial MHK cases. During FY 2011, two additional cases were added: a tidal project in the Gulf of Maine using Ocean Renewable Power Company TidGenTM turbines and a wave project planned for the coast of Oregon using Aquamarine Oyster surge devices. Through an iterative process, the screening analysis revealed that top-tier stressors in the two FY 2011 cases were the dynamic effects of the device (e.g., strike), accidents/disasters, and effects of the static physical presence of the device (e.g., habitat alteration). Receptor interactions with these stressors at the highest tiers of risk were dominated by threatened and endangered animals. Risk to the physical environment from changes in flow regime also ranked high. Peer review of this process and results will be conducted in early FY 2012. The ERES screening analysis provides an analysis of vulnerability of environmental receptors to stressors associated with MHK installations, probability analysis is needed to determine specific risk levels to receptors. �Risk� has two components: (1) The likelihood, or �probability�, of the occurrence of a given interaction or event, and (2) the potential �consequence� if that interaction or event were to occur. During FY 2011, the ERES screening analysis focused primarily on the second component of risk, �consequence�, with focused probability analysis for interactions where data was sufficient for probability modeling. Consequence analysis provides an assessment of vulnerability of environmental receptors to stressors associated with MHK installations. Probability analysis is needed to determine specific risk levels to receptors and requires significant data inputs to drive risk models. During FY 2011, two stressor-receptor interactions were examined for the probability of occurrence. The two interactions (spill probability due to an encounter between a surface vessel and an MHK device; and toxicity from anti-biofouling paints on MHK devices) were seen to present relatively low risks to marine and freshwater receptors of greatest concern in siting and permitting MHK devices. A third probability analysis was scoped and initial steps taken to understand the risk of encounter between marine animals and rotating turbine blades. This analysis will be completed in FY 2012.
Copping, Andrea E.; Blake, Kara M.; Anderson, Richard M.; Zdanski, Laura C.; Gill, Gary A.; Ward, Jeffrey A.
Updating Technical Screens for PV Interconnection: Preprint
Solar photovoltaics (PV) is the dominant type of distributed generation (DG) technology interconnected to electric distribution systems in the United States, and deployment of PV systems continues to increase rapidly. Considering the rapid growth and widespread deployment of PV systems in United States electric distribution grids, it is important that interconnection procedures be as streamlined as possible to avoid unnecessary interconnection studies, costs, and delays. Because many PV interconnection applications involve high penetration scenarios, the process needs to allow for a sufficiently rigorous technical evaluation to identify and address possible system impacts. Existing interconnection procedures are designed to balance the need for efficiency and technical rigor for all DG. However, there is an implicit expectation that those procedures will be updated over time in order to remain relevant with respect to evolving standards, technology, and practical experience. Modifications to interconnection screens and procedures must focus on maintaining or improving safety and reliability, as well as accurately allocating costs and improving expediency of the interconnection process. This paper evaluates the origins and usefulness of the capacity penetration screen, offers potential short-term solutions which could effectively allow fast-track interconnection to many PV system applications, and considers longer-term solutions for increasing PV deployment levels in a safe and reliable manner while reducing or eliminating the emphasis on the penetration screen.
Coddington, M.; Ellis, A.; Lynn, K.; Razon, A.; Key, T.; Kroposki, B.; Mather, B.; Hill, R.; Nicole, K.; Smith, J.
Statistical Algorithms for High-throughput Biological Data /
Nat Genet, Jun 2012. [LHW + 09] Heng Li, Bob Handsaker, Alec25(16):2078�2079, [Li11] Heng Li. Tabix: fast retrieval ofYang, Chun-Qing Song, Le-Heng Wang, Chao Liu, Yan Fu, Zuo-
Jeong, Kyowon
Operational streamlining in a high-throughput genome sequencing center
Advances in medicine rely on accurate data that is rapidly provided. It is therefore critical for the Genome Sequencing platform of the Broad Institute of MIT and Harvard to continually strive to reduce cost, improve ...
Person, Kerry P. (Kerry Patrick)
Methods and devices for high-throughput dielectrophoretic concentration
Disclosed herein are methods and devices for assaying and concentrating analytes in a fluid sample using dielectrophoresis. As disclosed, the methods and devices utilize substrates having a plurality of pores through which analytes can be selectively prevented from passing, or inhibited, on application of an appropriate electric field waveform. The pores of the substrate produce nonuniform electric field having local extrema located near the pores. These nonuniform fields drive dielectrophoresis, which produces the inhibition. Arrangements of electrodes and porous substrates support continuous, bulk, multi-dimensional, and staged selective concentration.
Simmons, Blake A. (San Francisco, CA); Cummings, Eric B. (Livermore, CA); Fiechtner, Gregory J. (Germantown, MD); Fintschenko, Yolanda (Livermore, CA); McGraw, Gregory J. (Ann Arbor, MI); Salmi, Allen (Escalon, CA)
Integrated microbioreactor arrays for high-throughput experimentation
Bioprocesses with microbial cells play an important role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve ...
Lee, Harry, 1976-
ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D Ned Stetson, Larry Blair 1 , Grace Ordaz, Carole Read, George Thomas 2 , and Sunita Satyapal Suite 900, 7475...
Robust, High-Throughput Analysis of Protein Structures
described here, which the research team believes will help usher in the next phase of genomics research. The high flux, brilliance, and focus of the x rays from ALS Beamline 12.3.1...
High-Throughput Transfer Imprinting for Organic Semiconductors
focused infrared laser heats stamping layer(PMMA) up to glass transition temperature within very short time. And the pressure applied through the roller presses the flat mold and the pattern is imprinted on the PMMA layer. This method can imprint... with higher speed and achieved wider area of imprinting than conventional imprint method. [17] MOLD Substrate PMMA IR Roller Figure 8 Concept of roller imprinting based on focus infrared heating. 17 CHAPTER II PROBLEM STATEMENT...
Choo, Gihoon
Computational tools for high-throughput discovery in biology
approach of a Service Oriented Architecture, where softwaredescribed as a �service oriented architecture. � Several ofWhile a Service Oriented Architecture (usually implemented
Jones, Neil Christopher
Technology Offer High-throughput Algorithm for Automated
reliability enables the same LC-MS analyses with less human resources as manual correction is not necessary Chemical industry: identification and quantitation of chemical composition of various analytes, e.g. oils
High throughput analysis of samples in flowing liquid
Apparatus and method enable imaging multiple fluorescent sample particles in a single flow channel. A flow channel defines a flow direction for samples in a flow stream and has a viewing plane perpendicular to the flow direction. A laser beam is formed as a ribbon having a width effective to cover the viewing plane. Imaging optics are arranged to view the viewing plane to form an image of the fluorescent sample particles in the flow stream, and a camera records the image formed by the imaging optics.
Ambrose, W. Patrick (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Goodwin, Peter M. (Los Alamos, NM); Jett, James H. (Los Alamos, NM); Orden, Alan Van (Fort Collins, CO); Keller, Richard A. (White Rock, NM)
Optical Multiplexing for High-Throughput Spectroscopic Analysis.
in optical biosensor testing as it provides greater throughput and scalability while being an economical and compact solution. v NOMENCLATURE MFPF Multi Frequency Phase Fluorometer MUX Multiplexer LED Light Emitting Diode DIO Digital Input... oxidase in hybrid silicate microsphere that is coated with nanofilm and reference dye (RITC) (Fig. 1) [2]. The phosphorescent dye is excited by a green light from a LED (light emitting diode) to emit luminescence, the intensity of which is dependent...
Ahmed, Saadiah
High-throughput comparison of gene fitness among related bacteria
licenses/by/2.0), which permits unrestricted use,Mutations in this gene permit second site mutations in hnsIt is known that rpoS mutants permit mutations in hns in
Vectorized AES core for high-throughput secure environments
`odul D6 Campus Nord, 08034 Barcelona, Spain Phone: +34 934 017 001, Fax: +34 934 017 055 mpericas the evaluation of an encryption core capable of handling multiple data streams. The de- sign is oriented towards cryptographic engines with multiple streams to better exploit the available bandwidth. Several specific cases
High-throughput Synthesis and Metrology of Graphene Materials
24 2.5 Demonstration of PGN based Supercapacitor2-11 (a) CV curves of supercapacitor based on as-grown PGNFigure 2-12 CV curves of supercapacitor based on HNO3 acid
Ghazinejad, Maziar Ghazinejad
and theory - Materials Discovery DOE BES Hydrogen Fuel Initiative * Structure and dynamics (Neutron and NMR) - Experimental and computational studies of di- hydrogen bonding...
Low inlet gas velocity high throughput biomass gasifier
The present invention discloses a novel method of operating a gasifier for production of fuel gas from carbonaceous fuels. The process disclosed enables operating in an entrained mode using inlet gas velocities of less than 7 feet per second, feedstock throughputs exceeding 4000 lbs/ft.sup.2 -hr, and pressures below 100 psia.
Feldmann, Herman F. (Worthington, OH); Paisley, Mark A. (Upper Arlington, OH)
Targeted Tandem Mass Spectrometry for High-Throughput Comparative
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Catalyst Structure-Performance Relationship Identified by High-Throughput
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High Throughput Operando Studies using Fourier Transform Infrared Imaging
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AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared0 Resource Program SeptemberRobertIntelligentRobust,Robust,
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared0 Resource Program SeptemberRobertIntelligentRobust,Robust,Robust,
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Potential of High-Throughput Experimentation with Ammonia Borane Solid
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion | Department ofT ib l L d FNEPA/309 Reviewers | DepartmentSiteMaryland | YieldHydrogen Storage
High-Throughput Analytical Model to Evaluate Materials for Temperature
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High-Throughput Characterization of Porous Materials Using Graphics
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Automated Purification of Recombinant Proteins: Combining High-throughput
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Advancing the High Throughput Identification of Liver Fibrosis Protein
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Antibody Microarrays for High-Throughput, Multianalyte Analysis. | EMSL
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Electron screening in nickel
In order to further investigate electron screening phenomenon we studied proton induced nuclear reactions over an energy range from 1.35 to 3.08 MeV for different environments: Ni metal and NiO insulator. The measurements were based on observation of the {gamma}-ray yields of {sup 59,61,63,64,65}Cu and {sup 58,60,62}Ni. Also, we have studied the decay of {sup 61}Cu produced in the reaction {sup 60}Ni(p,{gamma}), in order to find a possible decay rate perturbation by atomic electrons and found a small difference in half-life for metallic compared to oxide environment, respectively. The present results clearly show that the metallic environment affects the fusion reactions at low energy and that it might also affect the decay rate.
Gajevic, Jelena; Lipoglavsek, Matej; Petrovic, Toni; Pelicon, Primoz [Jozef Stefan Institute, Jamova cesta 39, Ljubljana (Slovenia); Jozef Stefan Institute, Jamova cesta 39, Ljubljana (Slovenia) and Cosylab d.d, Teslova ulica 30, Ljubljana (Slovenia); Jozef Stefan Institute, Jamova cesta 39, Ljubljana (Slovenia)
Protein Dynamics Hit the Big Screen
Protein Dynamics Hit the Big Screen Protein Dynamics Hit the Big Screen Now playing at a supercomputer near you: proteins in action June 29, 2005 Contact: Dan Krotz,...
Mixed Alcohol Synthesis Catalyst Screening
National Renewable Energy Laboratory (NREL) and Pacific Northwest National Laboratory (PNNL) are conducting research to investigate the feasibility of producing mixed alcohols from biomass-derived synthesis gas (syngas). PNNL is tasked with obtaining commercially available or preparing promising mixed-alcohol catalysts and screening them in a laboratory-scale reactor system. Commercially available catalysts and the most promising experimental catalysts are provided to NREL for testing using a slipstream from a pilot-scale biomass gasifier. From the standpoint of producing C2+ alcohols as the major product, it appears that the rhodium catalyst is the best choice in terms of both selectivity and space-time yield (STY). However, unless the rhodium catalyst can be improved to provide minimally acceptable STYs for commercial operation, mixed alcohol synthesis will involve significant production of other liquid coproducts. The modified Fischer-Tropsch catalyst shows the most promise for providing both an acceptable selectivity to C2+ alcohols and total liquid STY. However, further optimization of the Fischer-Tropsch catalysts to improve selectivity to higher alcohols is highly desired. Selection of a preferred catalyst will likely entail a decision on the preferred coproduct slate. No other catalysts tested appear amenable to the significant improvements needed for acceptable STYs.
Gerber, Mark A.; White, James F.; Stevens, Don J.
Optimal Screening for Preclinical Diseases
for our model, and that it can be quickly found by any greedy-search algorithm. We further conduct numerical experimentations by which we identify sensitive model inputs. We lastly apply our model to breast cancer screening using practical information...
Li, Ang
Rare earth phosphors and phosphor screens
This invention relates to rare earth phosphor screens for converting image carrying incident radiation to image carrying visible or near-visible radiation and to the rare earth phosphor materials utilized in such screens. The invention further relates to methods for converting image carrying charged particles to image carrying radiation principally in the blue and near-ultraviolet region of the spectrum and to stabilized rare earth phosphors characterized by having a continuous surface layer of the phosphors of the invention. More particularly, the phosphors of the invention are oxychlorides and oxybromides of yttrium, lanthanum and gadolinium activated with trivalent cerium and the conversion screens are of the type illustratively including x-ray conversion screens, image amplifier tube screens, neutron imaging screens, cathode ray tube screens, high energy gamma ray screens, scintillation detector screens and screens for real-time translation of image carrying high energy radiation to image carrying visible or near-visible radiation.
Buchanan, Robert A. (Palo Alto, CA); Maple, T. Grant (Sunnyvale, CA); Sklensky, Alden F. (Sunnyvale, CA)
Screening of quark-monopole in N=4 plasma
We study a quark-monopole bound system moving in N=4 SYM plasma with a constant velocity by the AdS/CFT correspondence. The screening length of this system is calculated, and is smaller than that of the quark-antiquark bound state.
Wei-shui Xu; Ding-fang Zeng
Control System Design for Automatic Cavity Tuning Machines
A series of four automatic tuning machines for 9-cell TESLA-type cavities are being developed and fabricated in a collaborative effort among DESY, FNAL, and KEK. These machines are intended to support high-throughput cavity fabrication for construction of large SRF-based accelerator projects. Two of these machines will be delivered to cavity vendors for the tuning of XFEL cavities. The control system for these machines must support a high level of automation adequate for industrial use by non-experts operators. This paper describes the control system hardware and software design for these machines.
Carcagno, R.; Khabiboulline, T.; Kotelnikov, S.; Makulski, A.; Nehring, R.; Nogiec, J.; Ross, M.; Schappert, W.; /Fermilab; Goessel, A.; Iversen, J.; Klinke, D.; /DESY
Brighter Screens for Nondestructive Digital X-ray Radiography
Fine resolution, bright X-ray screens are needed for digital radiography and material characterization at the Y-12 National Security Complex (Y-12). Current technology is simply not adequate for transferring high-energy X-ray images to visible light for demanding digital applications. Low energy radiography and especially emerging tomographic technologies are severely hampered for Y-12 nondestructive evaluation (NDE) applications by dim screens with poor resolution. Also, the development of more advanced materials characterization techniques, such as electron backscatter diffraction (EBSD), is driven by a design agency desire for tighter specifications and more uniform materials. Brighter screens would allow us to probe materials on a finer scale, leading to a better understanding of material behavior. A number of X-ray screen materials were studied that would be suitable for direct replacement in existing digital imaging systems. Spectroscopic evaluations were first made for a several candidates and indicated that lutetium orthosilicate (LSO) would be a promising candidate for MeV images. A relative comparison of brightness at various energies was then completed which showed that cesium iodide (CsI) could increase brightness by over an order of magnitude. Since image quality is also important for better screens, the resolving capabilities of candidate materials were measured. Resolution measurements were completed at X-ray peak energies up to 420KeV with magnified optical imaging systems, and indicated that LSO and Industrial Quality Incorporated glass (IQI) exhibited higher resolution than the CsI screen. The results give a choice of materials that can be tailored to the particular test under consideration. If high-speed images are necessary and some resolution can be sacrificed, the CsI screen will be a good choice. The screen can be replaced by an IQI or LSO unit if higher resolution is needed later, for instance to focus in on a region of interest. A number of significant findings were obtained from this study. Most important of the findings was that materials are commercially available that are much brighter than screens currently in use. This finding meets the original objective of the project. Two objectives of the study; however, were not met. We hoped to evaluate a 'quantum dot' (nanometer-sized particles of semiconductor material) wavelength conversion screen, but the manufacturer ceased production of the screen shortly before the project was started. The dot screen could be efficient in converting ultraviolet light to visible light which would have proved important for utilizing a Cherenkov screen. Since this was a very new, cutting-edge technology, an alternative supplier was not found during the study. Also, high-energy testing of a Cherenkov light screen was not performed due to difficulties in obtaining appropriate approvals for locating test equipment in the high-energy X-ray vault at Y-12. The test is still important, and is being pursued through follow-on funding sources. Although many film shots will be eliminated by the availability of high quality digital images, the largest potential gains result from the availability of clearer images that show fine detail in the parts under analysis. Digital radiographic data also offers the possibility of easily sharing data with other sites. This could prove invaluable when critical material, placement, assembly, or quality issues are pressing. Also, increased throughput in the NDE facility allows statistically significant numbers of units to be analyzed. Digital technologies may in fact be needed just to meet minimum requirements of future demands. Increased brightness screens allow for such innovations as 3-D tomographic images to be acquired in a reasonable time. Much of the skill required to interpret 'flattened' X-ray images is not needed to maneuver around the reconstructed tomogram. This study showed that several commercially available materials are much brighter than screens currently in use. The study also showed that materials othe
Miller, Jr., A. C.; Bell, Z. W.; Carpenter, D. A.
Walla Walla River Basin Fish Screens Evaluations, 2006 Annual Report.
Pacific Northwest National Laboratory evaluated Gardena Farms, Little Walla Walla, and Garden City/Lowden II Phase II fish screen facilities and provided underwater videography beneath a leaking rubber dam in the Walla Walla River basin in 2006. Evaluations of the fish screen facilities took place in early May 2006, when juvenile salmonids are generally outmigrating. At the Gardena Farms site, extended high river levels caused accumulations of debris and sediment in the forebay. This debris covered parts of the bottom drum seals, which could lead to early deterioration of the seals and drum screen. Approach velocities were excessive at the upstream corners of most of the drums, leading to 14% of the total approach velocities exceeding 0.4 feet per second (ft/s). Consequently, the approach velocities did not meet National Marine Fisheries Service (NMFS) design criteria guidelines for juvenile fish screens. The Little Walla Walla site was found to be in good condition, with all approach, sweep, and bypass velocities within NMFS criteria. Sediment buildup was minor and did not affect the effectiveness of the screens. At Garden City/Lowden II, 94% of approach velocities met NMFS criteria of 0.4 ft/s at any time. Sweep velocities increased toward the fish ladder. The air-burst mechanism appears to keep large debris off the screens, although it does not prevent algae and periphyton from growing on the screen face, especially near the bottom of the screens. In August 2006, the Gardena Farm Irrigation District personnel requested that we look for a leak beneath the inflatable rubber dam at the Garden City/Lowden II site that was preventing water movement through the fish ladder. Using our underwater video equipment, we were able to find a gap in the sheet piling beneath the dam. Erosion of the riverbed was occurring around this gap, allowing water and cobbles to move beneath the dam. The construction engineers and irrigation district staff were able to use the video footage to resolve the problem within a couple weeks. We had hoped to also evaluate the effectiveness of modifications to louvers behind the Nursery Bridge screens when flows were higher than 350 cubic feet per second, (cfs) but were unable to do so. Based on the one measurement made in early 2006 after the modified louvers were set, it appears the modified louvers may help reduce approach velocities. The auxiliary supply water system gates also control water through the screens. Evaluating the effect of different combinations of gate and louver positions on approach velocities through the screens may help identify optimum settings for both at different river discharges.
Chamness, Mickie; Abernethy, Scott; Tunnicliffe, Cherylyn [Pacific Northwest National Laboratory
Screening Pumping Systems for Energy Savings Opportunities
engineering study of, in some cases, hundreds of pumps within their facilities to understand the energy costs and the potential opportunity for reduction. Under the auspices of the Department of Energy's (DOE) Motor Challenge Program, prescreening... improvement opportunities. This paper describes the general methodologies employed and shows case study examples of the prescreening and software application. Oak Ridge National Laboratory Oak Ridge, Tennessee BACKGROUND Motor Challenge The main goal...
Casada, D.
AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism inS-4500II Field Emission SEM with EDAXUpdated CapitalMichael
DOE: Former Worker Medical Screening Program (FWP)
FWP provides no-cost medical screenings to all former DOE Federal, contractor and subcontractor employees. The screening exams are offered by third party providers from universities, labor unions,...
Generalized charge-screening in relativistic Thomas�Fermi model
In this paper, we study the charge shielding within the relativistic Thomas-Fermi model for a wide range of electron number-densities and the atomic-number of screened ions. A generalized energy-density relation is obtained using the force-balance equation and taking into account the Chandrasekhar's relativistic electron degeneracy pressure. By numerically solving a second-order nonlinear differential equation, the Thomas-Fermi screening length is investigated, and the results are compared for three distinct regimes of the solid-density, warm-dense-matter, and white-dwarfs (WDs). It is revealed that our nonlinear screening theory is compatible with the exponentially decaying Thomas-Fermi-type shielding predicted by the linear response theory. Moreover, the variation of relative Thomas-Fermi screening length shows that extremely dense quantum electron fluids are relatively poor charge shielders. Calculation of the total number of screening electrons around a nucleus shows that there is a position of maximum number of screening localized electrons around the screened nucleus, which moves closer to the point-like nucleus by increase in the plasma number density but is unaffected due to increase in the atomic-number value. It is discovered that the total number of screening electrons, (N{sub s}?r{sub TF}{sup 3}/r{sub d}{sup 3} where r{sub TF} and r{sub d} are the Thomas-Fermi and interparticle distance, respectively) has a distinct limit for extremely dense plasmas such as WD-cores and neutron star crusts, which is unique for all given values of the atomic-number. This is equal to saying that in an ultrarelativistic degeneracy limit of electron-ion plasma, the screening length couples with the system dimensionality and the plasma becomes spherically self-similar. Current analysis can provide useful information on the effects of relativistic correction to the charge screening for a wide range of plasma density, such as the inertial-confined plasmas and compact stellar objects.
Akbari-Moghanjoughi, M. [Department of Physics, Faculty of Sciences, Azarbaijan Shahid Madani University, 51745-406 Tabriz, Iran and International Centre for Advanced Studies in Physical Sciences and Institute for Theoretical Physics, Ruhr University Bochum, D-44780 Bochum (Germany)
MR SCREENING FORM FOR RESEARCH STAFF Page 1 of 2
MR SCREENING FORM FOR RESEARCH STAFF Page 1 of 2 (PLEASE PRINT) NAME DATE: Before entering the MR environment or MR system room, you must remove all metallic objects including hearing aids, dentures, partial may be advised or required to wear earplugs or other hearing protection during the MR procedure
Undergraduate research semester internship spring 1999 abstracts and research papers
This report consists of the following titles: (1) Development of Sieving Media for DNA Sequencing; (2) Protein-Protein Interaction Specificity of a Human Exonuclease; (3) Cascading Modular Biotreatment System--From Conceptual Design to Field Tests; (4) Detecting the Unseen Enemies--Biological Warfare; and (5) Development of a Functional Chip for High-Throughput Screening of Protein-DNA Interactions.
Dibble, S; Fernandez, A; Mayers, C; Omikunle, A; Weiss, O
Federal Renewable Energy Screening Assistant
The Federal Renewable Energy Screening Assistant is a software tool to be used by energy auditors to prioritize future studies of potentially cost-effective renewable energy applications at federal facilities. This paper describes the structure and function of the tool, gives an inventory of renewable energy technologies represented in the tool, and briefly describes the algorithms used to rank opportunities by the savings-to-investment ratio.
Shelpuk, B [Natural Energy Resources Unlimited, Evergreen, CO (United States); Walker, A [National Renewable Energy Lab., Golden, CO (United States)
This new system will allow researchers to much more rapidly screen large numbers of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio-
of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio- fuels conversion processes. NREL will be screening thousands of variants of different biomass feedstocks to link to develop the next generation of low-cost, easily convert- ible biomass feedstocks. To identify superior
Decision trees and integrated features for computer aided mammographic screening
Breast cancer is a serious problem, which in the United States causes 43,000 deaths a year, eventually striking 1 in 9 women. Early detection is the only effective countermeasure, and mass mammography screening is the only reliable means for early detection. Mass screening has many shortcomings which could be addressed by a computer-aided mammographic screening system. Accordingly, we have applied the pattern recognition methods developed in earlier investigations of speculated lesions in mammograms to the detection of microcalcifications and circumscribed masses, generating new, more rigorous and uniform methods for the detection of both those signs. We have also improved the pattern recognition methods themselves, through the development of a new approach to combinations of multiple classifiers.
Kegelmeyer, W.P. Jr.; Groshong, B.; Allmen, M.; Woods, K.
Former worekrs' notification adn medical screening Hanford
CPWR is carrying out a screening program for former Hanford construction workers. This program includes continuing screening and re-screening services for the former worker population. The Program contains the following general components: Start-up planning/needs assessment: A modified exposure assessment will be conducted to identify high-risk buildings or areas, primary exposures, and worker populations at risk. Outreach: CPWR, as the research arm of the Building and Construction Trades Department, AFL-CIO, has direct access to workers. CPWR will rely on direct mailings to lists of former workers, and work through and rely on existing organizations (unions, union pension funds, employers, DOE site administrators, etc.) to reach former workers and "get the word out." CPWR will establish/maintain an outreach office at each site listed above. This office will serve as the face of the Program to workers and their communities. Communications and intake center: CPWR has two established toll-free phone numbers (1-800-866-9663 and 1-888-464-0009). There is also a dedicated website for the program (btmed.org). Workers can register with the Program by mail, telephone, or on-line. Work history: A standardized, structured work history is administered with modules that accommodate unique exposure scenarios for different occupations and different DOE sites. A work history interview is administered by a trained program interviewer. The work histories are used to determine whether a participant is eligible for the medical examination and to interpret the findings from the medical examination. Medical evaluation: The Program contracts with local medical providers qualified to deliver occupational medical screening services. All providers are credentialed. The Program contracts with a certified national laboratory and with NIOSH certified B-readers to review x-rays. Based on the work history, the participant is referred to a credentialed medical provider who is located close to the participant's home. If it is not convenient to use a credentialed provider, the Program will make arrangements, if necessary, for the participant to receive a physical exam through the National Supplemental Screening Program. Eligible participants will receive the same core medical exam (including a Beryllium Lymphocyte Proliferation Test, BeLPT), and in addition, based on their work history, they may be assigned to exposure specific modules for asbestos, silica, lead, noise, cadmium, and chromium. Lab work will be sent to a national laboratory for processing, except the blood samples for the BeLPT, which will be sent to a DOE-approved laboratory for evaluation. Determination of work-relatedness and follow-up: A letter of findings will be sent to the participant within 60 days of the exam. The letter is written and/or reviewed by occupational medical health personnel with knowledge of the DOE site(s) where the participant has worked and will include specific follow-up recommendations. Urgent findings are followed up by the provider without delay. Evaluation and quality assurance: All data are entered into the Program Data Management System (DMS). The DMS is web-based and relies on electronic submission of results, whenever possible. A de-identified data set on all participants is provided to Duke University Medical Center for evaluation and analysis. Each participant is asked to complete a satisfaction survey. The DMS will be used for quality assurance purposes and to also report summary data to the DOE. The BTMED.ORG website is encrypted using the industry-standard Secure Sockets Layer (SSL) technology (128-bit encryption keys). Each individual that accesses the website is assigned a unique login ID, password, and token. Passwords are required to meet standards for "strength," including minimum length, multi-case, and use of numbers. The website is also protected by additional security layers including additional encryption, hardware and software firewalls, Virtual Private Networks (VPNs), and virus protection.
Patricia Quinn
Reverberatory screen for a radiant burner
The present invention relates to porous mat gas fired radiant burner panels utilizing improved reverberatory screens. The purpose of these screens is to boost the overall radiant output of the burner relative to a burner using no screen and the same fuel-air flow rates. In one embodiment, the reverberatory screen is fabricated from ceramic composite material, which can withstand higher operating temperatures than its metallic equivalent. In another embodiment the reverberatory screen is corrugated. The corrugations add stiffness which helps to resist creep and thermally induced distortions due to temperature or thermal expansion coefficient differences. As an added benefit, it has been unexpectedly discovered that the corrugations further increase the radiant efficiency of the burner. In a preferred embodiment, the reverberatory screen is both corrugated and made from ceramic composite material.
Gray, Paul E. (North East, MD)
Screening masses in thermal and dense medium
Screening masses of different hadronic states are studied in thermal and dense medium on lattice. It has been found that screening masses increase with the temperature. In deconfinement phase, chemical potential enhances the screening masses. We use the normalization with respect to lowest Matsubara frequency to characterize dissolving of hadronic bound states at high temperatures. It has been found that different hadronic states have different dissolving temperatures and their survivals are considerably improved at finite chemical potentials.
A. Tawfik
Screen Electrode Materials & Cell Chemistries and Streamlining...
& Cell Chemistries and Streamlining Optimization of Electrode Screen Electrode Materials & Cell Chemistries and Streamlining Optimization of Electrode 2010 DOE Vehicle Technologies...
Phase Behavior of Pseudobinary Precious Metal?Carbide Systems
Transition metal carbides exhibit a variety of interesting material properties, including electrochemical stability. When combined with precious metals, Ta and W carbides have shown promise as fuel cell electrode materials; yet, the phase behavior of these precious metal?carbide systems is largely unexplored. We investigated P-M-C phase behavior with P = Pt, Pd, and Ru and M = Ta and W using composition spread thin films. We attained limited control of the deposited carbide phase through variation of the sputter atmosphere and demonstrated decreased corrosion of W?C materials with increasing C content. A high-throughput X-ray diffraction and X-ray fluorescence experiment was employed for thin film characterization, which revealed solubility of Pt, Pd, and Ru in cubic WC. Density functional calculations of the lattice parameter dependence on carbon concentration enabled the determination of carbon concentration from the X-ray data as a function of transition metal stoichiometry. Our measurement of variations in the C stoichiometry and evolution of thin film texture with transition metal composition yielded surprising results. We detail how the combination of the composition spread technique, the high-throughput thin film characterization, and the density functional modeling of ternary carbide alloys provided a deep understanding of the chemical systems.
Gregoire, John M.; Tague, Michele E.; Smith, Eva H.; Dale, Darren; DiSalvo, Francis J.; Abru�a, H�ctor D.; Hennig, Richard G.; van Dover, R. Bruce
NARES CULTURE FOR MRSA SCREENING I. INTRODUCTION Active Surveillance Testing (AST) to detect newly admitted patients who are nasally colonized with MRSA is required in 2009 to comply with California Health an anterior nares specimen for MRSA screening. III. SUPPLIES 1. For children, adolescents and adults: BD BBL
Kay, Mark A.
RICE UNIVERSITY Screened Coulomb Hybrid Density Functionals
in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy Approved, Thesis Committee-Scuseria-Ernzerhof (HSE) screened Coulomb hybrid density functional is designed to produce exchange energies comparable to traditional hybrids while only using the short range, screened HF exchange. #12;The accuracy of the HSE
Scuseria, Gustavo E.
Page 1 of 100 Full Screen
()d. #12;Home Page Title Page Contents Page 7 of 100 Go Back Full Screen Close Quit The behavior of bothHome Page Title Page Contents Page 1 of 100 Go Back Full Screen Close Quit Scenario Generation Uncertainty Quantification in Industrial and Energy Applications: Experiences and Challenges, Minneapolis
Römisch, Werner
Portuguese Ships on Japanese Namban Screens
Namban screens are a well-known Japanese art form that was produced between the end of the 16th century and throughout the 17th century. More than 90 of these screens survive today. They possess substantial historical value because they display...
Yamafune, Kotaro
What is Systems Biology? Computational Biology Laboratory
of high-throughput experimental techniques micro-array (1995), mass spectrometry of proteins (1987), 2D* Proteins, energy, functions, etc. Building Blueprint Machines & workers Energy & supplies Physical plant gene-disruption data ·(proteinprotein interaction) yeast two- hybrid data ·Many high-throughput exp
Lee, H.C. Paul
U.S. Department of Energy Categorical Exclusion Determination...
2) LBNL & Wildcat Disc. Tech - High Throughput Tools to Screen New Metal Organic Framework Materials Location: California Proposed Action or Project Description: American Recovcl)'...
artificial neural analysis: Topics by E-print Network
Databases and Resources Websites Summary: Applications of Artificial Neural Networks and Fuzzy Models in High Throughput Screening to the existing HTS method, via Quantitative...
E-Print Network 3.0 - anti-arrhythmic anti-hypertensiveanti...
Chemistry & High-Throughput Screening., in press Summary: on the reductive amination and Ugi reactions using as queries a known anti-arrhythmic agent and a product inhibitor...
E-Print Network 3.0 - advance lab-on-a-chip devices Sample Search...
Detlev Belder... * droplets high-throughput screening lab-on-a-chip microfluidics Microfluidic laboratories, ... Source: Ismagilov, Rustem F. - Department of...
E-Print Network 3.0 - automated cell-based assay Sample Search...
array could potentially assay 100 different cell-based experiments... . Keywords: microfluidics; microbioreactor; cell culture; high-throughput screening; ... Source: Lee, Luke...
HT Combinatorial Screening of Novel Materials for High Capacity...
HT Combinatorial Screening of Novel Materials for High Capacity Hydrogen Storage HT Combinatorial Screening of Novel Materials for High Capacity Hydrogen Storage Presentation for...
Renewable Energy Resource Maps and Screening Tools | Department...
Resource Maps and Screening Tools Renewable Energy Resource Maps and Screening Tools Renewable energy resources are available across the United States but vary greatly depending on...
Disposable Carbon Nanotube Modified Screen-Printed Biosensor...
Carbon Nanotube Modified Screen-Printed Biosensor for Amperometric Detection of Organophosphorus Pesticides and Nerve Disposable Carbon Nanotube Modified Screen-Printed Biosensor...
The purpose of this report is to evaluate the potential for penetration of the Alloy 22 (UNS N06022) waste package outer barrier by localized corrosion due to the deliquescence of soluble constituents in dust present on waste package surfaces. The results support a recommendation to exclude deliquescence-induced localized corrosion (pitting or crevice corrosion) of the outer barrier from the total system performance assessment for the license application (TSPA-LA). Preparation of this report, and supporting laboratory studies and calculations, were performed as part of the planned effort in Work Package AEBM21, as implemented in ''Technical Work Plan for: Screening Evaluation for Dust Deliquescence and Localized Corrosion'' (BSC 2004 [DIRS 172804]), by Bechtel SAIC Company, LLC, and staff from three national laboratories: Sandia National Laboratories, Lawrence Livermore National Laboratory (LLNL), and Lawrence Berkeley National Laboratory (LBNL). The analysis and conclusions presented in this report are quality affecting, as determined in the controlling technical work plan. A summary of background information, based on work that was not performed under a quality assurance program, is provided as Appendix E. In this instance, the use of unqualified information is provided for transparency and corroboration only, and is clearly separated from uses of qualified information. Thus, the qualification status of this information does not affect the conclusions of this report. The acceptance criteria addressed in Sections 4.2 and 7.2 were changed from the technical work plan in response to review comments received during preparation of this report.
C. Bryan
Reactor control system upgrade for the McClellan Nuclear Radiation Center Sacramento, CA.
Argonne National Laboratory is currently developing a new reactor control system for the McClellan Nuclear Radiation Facility. This new control system not only provides the same functionality as the existing control system in terms of graphic displays of reactor process variables, data archival capability, and manual, automatic, pulse and square-wave modes of operation, but adds to the functionality of the previous control system by incorporating signal processing algorithms for the validation of sensors and automatic calibration and verification of control rod worth curves. With the inclusion of these automated features, the intent of this control system is not to replace the operator but to make the process of controlling the reactor easier and safer for the operator. For instance, an automatic control rod calibration method reduces the amount of time to calibrate control rods from days to minutes, increasing overall reactor utilization. The control rod calibration curve, determined using the automatic calibration system, can be validated anytime after the calibration, as long as the reactor power is between 50W and 500W. This is done by banking all of the rods simultaneously and comparing the tabulated rod worth curves with a reactivity computer estimate. As long as the deviation between the tabulated values and the reactivity estimate is within a prescribed error band, then the system is in calibration. In order to minimize the amount of information displayed, only the essential flux-related data are displayed in graphical format on the control screen. Information from the sensor validation methods is communicated to the operators via messages, which appear in a message window. The messages inform the operators that the actual process variables do not correlate within the allowed uncertainty in the reactor system. These warnings, however, cannot cause the reactor to shutdown automatically. The reactor operator has the ultimate responsibility of using this information to either keep the reactor operating or to shut the reactor down. In addition to new developments in the signal processing realm, the new control system will be migrating from a PC-based computer platform to a Sun Solaris-based computer platform. The proven history of stability and performance of the Sun Sohuis operating system are the main advantages to this change. The I/O system will also be migrating from a PC-based data collection system, which communicates plant data to the control computer using RS-232 connections, to an Ethernet-based I/O system. The Ethernet Data Acquisition System (EDAS) modules from Intelligent Instrumentation, Inc. provide an excellent solution for embedded control of a system using the more universally-accepted data transmission standard of TCP/IP. The modules contain a PROM, which operates all of the functionality of the I/O module, including the TCP/IP network access. Thus the module does not have an internal, sophisticated operating system to provide functionality but rather a small set hard-coded of instructions, which almost eliminates the possibility of the module failing due to software problems. An internal EEPROM can be modified over the Internet to change module configurations. Once configured, the module is contacted just like any other Internet host using TCP/IP socket calls. The main advantage to this architecture is its flexibility, expandability, and high throughput.
Power, M. A.
Qualitative vs. quantitative data: Controls on the accuracy of PID field screening in petroleum contamination assessment applications
The use of photoionization detectors (PIDs) for field screening of soils for volatile organic contaminants has become a standard industry practice. PID screening data is generally utilized as a qualitative basis for selection of samples for laboratory analysis to quantify concentrations of specific contaminants of concern. Both qualitative field screening data and quantitative laboratory analytical data were reviewed for more than 100 hydrogeologic assessment sites in Ohio to evaluate controls on the effectiveness of field screening data. Assessment data evaluated was limited to sites at which the suspected contaminant source was a gasoline underground storage tanks system. In each case, a 10.0 eV (or greater) PID calibrated for benzene was used to screen soils which were analyzed for benzene, toluene, ethylbenzene and xylene (BTEX) by SW 846 method 8020. Controls on field screening which were evaluated for each site included (1) soil classification, (2) soil moisture, (3) weather conditions, (4) background levels, (5) equipment quality, (6) screening methodology, and (7) laboratory QA/QC. Statistical data analysis predictably indicated a general overestimate of total BTEX levels based on field screening (gasoline is approximately 25 weight percent BTEX). However, data locally indicated cases of both significant (i.e., more than an order of magnitude difference) over- and under-estimation of actual BTEX concentrations (i.e., quantitative laboratory data) by field screening data.
Luessen, M.J.; Allex, M.K.; Holzel, F.R. [ATEC Associates Inc., Cincinnati, OH (United States)
Species for the screening assessment. Columbia River Comprehensive Impact Assessment
Because of past nuclear production operations along the Columbia River, there is intense public and tribal interest in assessing any residual Hanford Site related contamination along the river from the Hanford Reach to the Pacific Ocean. The Columbia River Comprehensive Impact Assessment was proposed to address these concerns. The assessment of the Columbia River is being conducted in phases. The initial phase is a screening assessment of the risk, which addresses current environmental conditions for a range of potential uses. One component of the screening assessment estimates the risk from contaminants in the Columbia River to the environment. The objective of the ecological risk assessment is to determine whether contaminants from the Columbia River pose a significant threat to selected receptor species that exist in the river and riparian communities of the study area. This report (1) identifies the receptor species selected for the screening assessment of ecological risk and (2) describes the selection process. The species selection process consisted of two tiers. In Tier 1, a master species list was developed that included many plant and animal species known to occur in the aquatic and riparian systems of the Columbia River between Priest Rapids Dam and the Columbia River estuary. This master list was reduced to 368 species that occur in the study area (Priest Rapids Dam to McNary Dam). In Tier 2, the 181 Tier 1 species were qualitatively ranked based on a scoring of their potential exposure and sensitivity to contaminants using a conceptual exposure model for the study area.
Becker, J.M.; Brandt, C.A.; Dauble, D.D.; Maughan, A.D.; O`Neil, T.K.
Screening Level Risk Assessment for the New Waste Calcining Facility
This screening level risk assessment evaluates potential adverse human health and ecological impacts resulting from continued operations of the calciner at the New Waste Calcining Facility (NWCF) at the Idaho Nuclear Technology and Engineering Center (INTEC), Idaho National Engineering and Environmental Laboratory (INEEL). The assessment was conducted in accordance with the Environmental Protection Agency (EPA) report, Guidance for Performing Screening Level Risk Analyses at Combustion Facilities Burning Hazardous Waste. This screening guidance is intended to give a conservative estimate of the potential risks to determine whether a more refined assessment is warranted. The NWCF uses a fluidized-bed combustor to solidify (calcine) liquid radioactive mixed waste from the INTEC Tank Farm facility. Calciner off volatilized metal species, trace organic compounds, and low-levels of radionuclides. Conservative stack emission rates were calculated based on maximum waste solution feed samples, conservative assumptions for off gas partitioning of metals and organics, stack gas sampling for mercury, and conservative measurements of contaminant removal (decontamination factors) in the off gas treatment system. Stack emissions were modeled using the ISC3 air dispersion model to predict maximum particulate and vapor air concentrations and ground deposition rates. Results demonstrate that NWCF emissions calculated from best-available process knowledge would result in maximum onsite and offsite health and ecological impacts that are less then EPA-established criteria for operation of a combustion facility.
M. L. Abbott; K. N. Keck; R. E. Schindler; R. L. VanHorn; N. L. Hampton; M. B. Heiser
Pooled ORF Expression Technology (POET) USING PROTEOMICS TO SCREEN POOLS OF OPEN READING FRAMES FOR PROTEIN EXPRESSION*S
are greatly simplified. Small scale expression and purification of 12 positive clones identified by POET from as much protein as 12 negative clones. Larger scale expression and purification of six of the positive attempted (4). In the standard approach to high throughput protein ex- pression and purification used
A new screening method for fuel contamination in soils was recently developed as American Society for Testing and Materials (ASTM) Method D-583 1-95, Standard Test Method for Screening Fuels in Soils. This method uses low-toxicity chemicals and can be used to screen organic-rich soils. In addition, it is fast, easy, and inexpensive to perform. The screening method calls for extracting a sample of soil with isopropyl alcohol following treatment with calcium oxide. The resulting extract is filtered, and the ultraviolet absorbance of the extract is measured at 254 nm. Depending on the available information concerning the contaminant fuel type and availability of the contaminant fuel for calibration, the method can be used to determine the approximate concentration of fuel contamination, an estimated value of fuel contamination, or an indication of the presence or absence of fuel contamination. Fuels containing aromatic compounds, such as diesel fuel and gasoline, as well as other aromatic-containing hydrocarbon materials, such as motor oil, crude oil, and coal oil, can be determined. The screening method for fuels in soils was evaluated by conducting a collaborative study on the method and by using the method to screen soil samples at an actual field site. In the collaborative study, a sand and an organic soil spiked with various concentrations of diesel fuel were tested. Data from the collaborative study were used to determine the reproducibility (between participants) and repeatability (within participant) precision of the method for screening the test materials. The collaborative study data also provide information on the performance of portable field equipment versus laboratory equipment for performing the screening method and a comparison of diesel concentration values determined using the screening method versus a laboratory method. Data generated using the method to screen soil samples in the field provide information on the performance of the method in atypical real-world application.
Susan S. Sorini; John F. Schabron
Quantum corrections to screening at strong coupling
We compute a certain class of corrections to (specific) screening lengths in strongly coupled nonabelian plasmas using the AdS/CFT correspondence. In this holographic framework, these corrections arise from various higher curvature interactions modifying the leading Einstein gravity action. The changes in the screening lengths are perturbative in inverse powers of the 't Hooft coupling or of the number of colours, as can be made precise in the context where the dual gauge theory is superconformal. We also compare the results of these holographic calculations to lattice results for the analogous screening lengths in QCD. In particular, we apply these results within the program of making quantitative comparisons between the strongly coupled quark-gluon plasma and holographic descriptions of conformal field theory.
Ajay Singh; Aninda Sinha
Screening Cargo Containers to Remove a Terrorist Threat
Each year some 48 million cargo containers move between the world's ports. More than 6 million of these enter the U.S., but only about 2 percent are opened and inspected when they arrive at U.S. seaports. The West Coast ports of Los Angeles-Long Beach, Oakland, and Seattle alone process 11,000 containers per day, or about 8 containers per minute. Because of this high traffic volume, U.S. seaports are especially vulnerable to a terrorist attack. Illicit radioactive materials could be hidden in any one of the cargo-filled containers that arrive at U.S. ports. Yet, searching every shipment would be bring legitimate commercial activities to a halt. Improving security at U.S. ports is thus one of the nation's most difficult technical and practical challenges because the systems developed for screening cargo must operate in concert with ongoing seaport activities. Working at this intersection of commerce and national security, Lawrence Livermore researchers are applying their expertise in radiation science and detection to develop improved technologies for detecting hidden radioactive materials. One new technology being designed and tested at the Laboratory is a neutron interrogation system for cargo containers. This system will quickly screen incoming shipments to ensure that nuclear materials such as plutonium and highly enriched uranium (HEU) are not smuggled into the U.S.
Hazi, A
Water Velocity Measurements on a Vertical Barrier Screen at the Bonneville Dam Second Powerhouse
Fish screens at hydroelectric dams help to protect rearing and migrating fish by preventing them from passing through the turbines and directing them towards the bypass channels by providing a sweeping flow parallel to the screen. However, fish screens may actually be harmful to fish if they become impinged on the surface of the screen or become disoriented due to poor flow conditions near the screen. Recent modifications to the vertical barrier screens (VBS) at the Bonneville Dam second powerhouse (B2) intended to increase the guidance of juvenile salmonids into the juvenile bypass system (JBS) have resulted in high mortality and descaling rates of hatchery subyearling Chinook salmon during the 2008 juvenile salmonid passage season. To investigate the potential cause of the high mortality and descaling rates, an in situ water velocity measurement study was conducted using acoustic Doppler velocimeters (ADV) in the gatewell slot at Units 12A and 14A of B2. From the measurements collected the average approach velocity, sweep velocity, and the root mean square (RMS) value of the velocity fluctuations were calculated. The approach velocities measured across the face of the VBS varied but were mostly less than 0.3 m/s. The sweep velocities also showed large variances across the face of the VBS with most measurements being less than 1.5 m/s. This study revealed that the approach velocities exceeded criteria recommended by NOAA Fisheries and Washington State Department of Fish and Wildlife intended to improve fish passage conditions.
Hughes, James S.; Deng, Zhiqun; Weiland, Mark A.; Martinez, Jayson J.; Yuan, Yong
The ALICE analysis train system
In the ALICE experiment hundreds of users are analyzing big datasets on a Grid system. High throughput and short turn-around times are achieved by a centralized system called the LEGO trains. This system combines analysis from different users in so-called analysis trains which are then executed within the same Grid jobs thereby reducing the number of times the data needs to be read from the storage systems. The centralized trains improve the performance, the usability for users and the bookkeeping in comparison to single user analysis. The train system builds upon the already existing ALICE tools, i.e. the analysis framework as well as the Grid submission and monitoring infrastructure. The entry point to the train system is a web interface which is used to configure the analysis and the desired datasets as well as to test and submit the train. Several measures have been implemented to reduce the time a train needs to finish and to increase the CPU efficiency.
Markus Zimmermann; for the ALICE collaboration
Internship FBI Fingerprint Procedures and Additional Screenings
Internship FBI Fingerprint Procedures and Additional Screenings ALL INTERNS: Required by DESE/Full-Year Internship) or August 1st (Spring Internship) o Web application https to get your fingerprints taken for your internship: 4 digit Registration #2301 Cost - $44.80 Valid
Gering, Jon C.
Screening and Evaluation Tool (SET) Users Guide
This document is the users guide to using the Screening and Evaluation Tool (SET). SET is a tool for comparing multiple fuel cycle options against a common set of criteria and metrics. It does this using standard multi-attribute utility decision analysis methods.
Layne Pincock
D & D screening risk evaluation guidance
The Screening Risk Evaluation (SRE) guidance document is a set of guidelines provided for the uniform implementation of SREs performed on decontamination and decommissioning (D&D) facilities. Although this method has been developed for D&D facilities, it can be used for transition (EM-60) facilities as well. The SRE guidance produces screening risk scores reflecting levels of risk through the use of risk ranking indices. Five types of possible risk are calculated from the SRE: current releases, worker exposures, future releases, physical hazards, and criticality. The Current Release Index (CRI) calculates the current risk to human health and the environment, exterior to the building, from ongoing or probable releases within a one-year time period. The Worker Exposure Index (WEI) calculates the current risk to workers, occupants and visitors inside contaminated D&D facilities due to contaminant exposure. The Future Release Index (FRI) calculates the hypothetical risk of future releases of contaminants, after one year, to human health and the environment. The Physical Hazards Index (PHI) calculates the risks to human health due to factors other than that of contaminants. Criticality is approached as a modifying factor to the entire SRE, due to the fact that criticality issues are strictly regulated under DOE. Screening risk results will be tabulated in matrix form, and Total Risk will be calculated (weighted equation) to produce a score on which to base early action recommendations. Other recommendations from the screening risk scores will be made based either on individual index scores or from reweighted Total Risk calculations. All recommendations based on the SRE will be made based on a combination of screening risk scores, decision drivers, and other considerations, as determined on a project-by-project basis.
Robers, S.K.; Golden, K.M.; Wollert, D.A.
National Security Science and Technology Initiative: Air Cargo Screening
The non-intrusive inspection (NII) of consolidated air cargo carried on commercial passenger aircraft continues to be a technically challenging, high-priority requirement of the Department of Homeland Security's Science and Technology Directorate (DHS S&T), the Transportation Security Agency and the Federal Aviation Administration. The goal of deploying a screening system that can reliably and cost-effectively detect explosive threats in consolidated cargo without adversely affecting the flow of commerce will require significant technical advances that will take years to develop. To address this critical National Security need, the Battelle Memorial Institute (Battelle), under a Cooperative Research and Development Agreement (CRADA) with four of its associated US Department of Energy (DOE) National Laboratories (Oak Ridge, Pacific Northwest, Idaho, and Brookhaven), conducted a research and development initiative focused on identifying, evaluating, and integrating technologies for screening consolidated air cargo for the presence of explosive threats. Battelle invested $8.5M of internal research and development funds during fiscal years 2007 through 2009. The primary results of this effort are described in this document and can be summarized as follows: (1) Completed a gap analysis that identified threat signatures and observables, candidate technologies for detection, their current state of development, and provided recommendations for improvements to meet air cargo screening requirements. (2) Defined a Commodity/Threat/Detection matrix that focuses modeling and experimental efforts, identifies technology gaps and game-changing opportunities, and provides a means of summarizing current and emerging capabilities. (3) Defined key properties (e.g., elemental composition, average density, effective atomic weight) for basic commodity and explosive benchmarks, developed virtual models of the physical distributions (pallets) of three commodity types and three explosive benchmarks combinations, and conducted modeling and simulation studies to begin populating the matrix of commodities, threats, and detection technologies. (4) Designed and fabricated basic (homogeneous) commodity test pallets and fabricated inert stimulants to support experiments and to validate modeling/simulation results. (5) Developed/expanded the team's capabilities to conduct full-scale imaging (neutron and x-ray) experiments of air cargo commodities and explosive benchmarks. (6) Conducted experiments to improve the collection of trace particles of explosives from a variety of surfaces representative of air cargo materials by means of mechanical (air/vibration/pressure), thermal, and electrostatic methods. Air cargo screening is a difficult challenge that will require significant investment in both research and development to find a suitable solution to ensure the safety of passengers without significantly hindering the flow of commodities. The initiative funded by Battelle has positioned this group to make major contributions in meeting the air cargo challenge by developing collaborations, developing laboratory test systems, improving knowledge of the challenges (both technical and business) for air cargo screening, and increasing the understanding of the capabilities for current inspection methods (x-ray radiography, x-ray backscatter, etc.) and potential future inspection methods (neutron radiography, fusion of detector modalities, advanced trace detection, etc.). Lastly, air cargo screening is still an issue that will benefit from collaboration between Department of Energy Laboratories and Battelle. On January 7, 2010, DHS Secretary Napolitano joined White House Press Secretary Robert Gibbs and Assistant to the President for Counterterrorism and Homeland Security John Brennan to announce several recommendations DHS has made to the President for improving the technology and procedures used to protect air travel from acts of terrorism. (This announcement followed the 25 Dec'09 Delta/Northwest Airlines Flight 253 terror attack.) Secretary Napolitano out
Bingham, Philip R [ORNL; White, Tim [Pacific Northwest National Laboratory (PNNL); Cespedes, Ernesto [Idaho National Laboratory (INL); Bowerman, Biays [Brookhaven National Laboratory (BNL); Bush, John [Battelle
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, July 2010, p. 41364142 Vol. 76, No. 13 0099-2240/10/$12.00 doi:10.1128/AEM.03065-09
of a high-throughput (HTP) method for screening them is desirable. We describe here a new method using increased (11, 15, 25�27, 36), further work, including development of accurate high-throughput (HTP) methods. Methods have been developed for HTP screening of the viability of static biofilms (6, 28, 32, 33
Matin, A.C.
Laboratory to change vehicle traffic-screening regimen at vehicle...
Changes to vehicle traffic-screening Laboratory to change vehicle traffic-screening regimen at vehicle inspection station Lanes two through five will be open 24 hours a day and...
Microfluidic in vivo screen identifies compounds enhancing neuronal
Compound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens ...
Haggarty, Stephen
Screened Hybrid and DFT + U Studies of the Structural, Electronic...
Screened Hybrid and DFT + U Studies of the Structural, Electronic, and Optical Properties of U3O8. Screened Hybrid and DFT + U Studies of the Structural, Electronic, and Optical...
Weakly screened thermonuclear reactions in astrophysical plasmas: Improving Salpeter's model
This paper presents a detailed study of the electron degeneracy and nonlinear screening effects which play a crucial role in the validity of Salpeter's weak-screening model. The limitations of that model are investigated and an improved one is proposed which can take into account nonlinear screening effects. Its application to the solar pp reaction derives an accurate screening enhancement factor and provides a very reliable estimation of the associated neutrino flux uncertanties.
Theodore E. Liolios
Electron Cloud with Inverted Beam Screens
We report the results of computer simulations studying the effect of wrongly oriented LHC beam screens on the local electron-cloud heat load and density. At 3.5 or 7-TeV energy and for maximum secondary emission-yield values below 1.5, with the inverted sawtooth orientation about ten times higher heat load is expected than for the standard orientation, and the wrongly oriented sawtooth chambers could lead to a local heat-load bottleneck during the process of surface conditioning at 25-ns bunch spacing. The available cooling margin can be significantly increased by correcting the sawtooth orientations at least for two dipole magnets in LHC arc cells 26 and 32 R3, in order that there be no half-cell cooling loop containing more than one inverted screen.
Maury Cuna, H
A Semiconductor Microlaser for Intracavity Flow Cytometry
Semiconductor microlasers are attractive components for micro-analysis systems because of their ability to emit coherent intense light from a small aperture. By using a surface-emitting semiconductor geometry, we were able to incorporate fluid flow inside a laser microcavity for the first time. This confers significant advantages for high throughput screening of cells, particulates and fluid analytes in a sensitive microdevice. In this paper we discuss the intracavity microfluidics and present preliminary results with flowing blood and brain cells.
Akhil, O.; Copeland, G.C.; Dunne, J.L.; Gourley, P.L.; Hendricks, J.K.; McDonald, A.E.
Screening current effects in Josephson junction arrays
The purpose of this work is to compare the dynamics of arrays of Josephson junctions in presence of magnetic field in two different frameworks: the so called XY frustrated model with no self inductance and an approach that takes into account the screening currents (considering self inductances only). We show that while for a range of parameters the simpler model is sufficiently accurate, in a region of the parameter space solutions arise that are not contained in the XY model equations.
A. Petraglia; G. Filatrella; G. Rotoli
Screening technology reduces ash in spiral circuits
In 2006, the James River Coal Co. selected the Stack Sizer to remove the minus 100 mesh high ash clay fraction from the clean coal spiral product circuits at the McCoy-Elkhorn Bevins Branch prep plant and at the Blue Diamond Leatherwood prep plant in Kentucky. The Stack Sizer is a multi-deck, high-frequency vibrating screen capable of separations as fine as 75 microns when fitted with Derrick Corp.'s patented high open area urethane screen panels. Full-scale lab tests and more than 10 months of continuous production have confirmed that the Stack Sizer fitted with Derrick 100 micron urethane screen panels consistently produces a clean coal fraction that ranges from 8 to 10% ash. Currently, each five-deck Stack Sizer operating at the Bevins Branch and Leatherwood prep plants is producing approximately 33 tons per hour of clean coal containing about 9% ash. This represents a clean coal yield of about 75% and an ash reduction of about 11% from the feed slurry. 3 figs. 2 tabs.
Brodzik, P. [Derrick Corp., Buffalo, NY (United States)
SNP Calling Using Genotype Model Selection on High-Throughput Sequencing Data
10, March 2009. [35] Heng Li. Fastq format specification.Accessed: 10/16/2012. [36] Heng Li. Pileup format. http://Ac- cessed: 10/16/2012. [37] Heng Li. Mathematical notes on
Murillo, Gabriel Hiroshi
Larry Blair DOE Tom Boussie Symyx Technologies Bob Bowman JPL Larry Cook NIST Alan Cooper Air Products Kristin Deason Sentech Pete DeSanto Air Products R. Greg Downing NIST Mike...
Evaluation of a New Remote Handling Design for High Throughput Annular Centrifugal Contactors
Advanced designs of nuclear fuel recycling plants are expected to include more ambitious goals for aqueous based separations including; higher separations efficiency, high-level waste minimization, and a greater focus on continuous processes to minimize cost and footprint. Therefore, Annular Centrifugal Contactors (ACCs) are destined to play a more important role for such future processing schemes. Previous efforts defined and characterized the performance of commercial 5 cm and 12.5 cm single-stage ACCs in a �cold� environment. The next logical step, the design and evaluation of remote capable pilot scale ACCs in a �hot� or radioactive environment was reported earlier. This report includes the development of remote designs for ACCs that can process the large throughput rates needed in future nuclear fuel recycling plants. Novel designs were developed for the remote interconnection of contactor units, clean-in-place and drain connections, and a new solids removal collection chamber. A three stage, 12.5 cm diameter rotor module has been constructed and evaluated for operational function and remote handling in highly radioactive environments. This design is scalable to commercial CINC ACC models from V-05 to V-20 with total throughput rates ranging from 20 to 650 liters per minute. The V-05R three stage prototype was manufactured by the commercial vendor for ACCs in the U.S., CINC mfg. It employs three standard V-05 clean-in-place (CIP) units modified for remote service and replacement via new methods of connection for solution inlets, outlets, drain and CIP. Hydraulic testing and functional checks were successfully conducted and then the prototype was evaluated for remote handling and maintenance suitability. Removal and replacement of the center position V-05R ACC unit in the three stage prototype was demonstrated using an overhead rail mounted PaR manipulator. This evaluation confirmed the efficacy of this innovative design for interconnecting and cleaning individual stages while retaining the benefits of commercially reliable ACC equipment for remote applications in the nuclear industry. Minor modifications and suggestions for improved manual remote servicing by the remote handling specialists were provided but successful removal and replacement was demonstrated in the first prototype.
David H. Meikrantz; Troy G. Garn; Jack D. Law; Lawrence L. Macaluso
VLPW: The Very Long Packet Window Architecture for High Throughput Network-On-Chip Router Designs
-chip routers and the ideal interconnect fabric. To improve throughput, VLPW optimizes Switch Allocation (SA) efficiency. Existing SA normally applies Round-Robin scheduling to arbitrate among the packets targeting the same output port. However, this simple...
Gu, Haiyin
Polymer microfluidic device for high-throughput single-cell encapsulation, lysis, and biological assay
rheology through microfluidics,� Advanced Materials, vol.Berthier and P. Silberzan, Microfluidics for Biotechnology.A. P. Lee, �Droplet microfluidics,� Lab on a Chip, vol. 8,
Brackbill, Timothy Peter
High Throughput Identification, Purification and Structural Characterization of Water Soluble Protein Complexes in Desulfovibrio vulgaris
Our scheme for the tagless purification of water soluble complexes. 10 g of protein from a crude bacterial extract is first fractionated by ammonium sulfate precipitation and then by a series of chromatographic steps: anion exchange (IEX), hydrophobic interaction (HIC), and finally size exclusion (Gel Filtration). Fractions from the last chromatography step are trypsin digested and peptides labeled with iTRAQ reagents to allow multiplexing and quantitation during mass spectrometric analysis. Elution profiles of identified proteins are then subjected to clustering analysis.
Dong,, Ming; Han, Bong-Gyoon; Liu, Hui-Hai; Malik, J.; Geller, Jil; Yang, Li; Choi, M.; Chandonia, John-Marc; Arbelaez, Pablo; Sterling, H. J.; Typke, Dieter; Shatsky, Max; Brenner, Steve; Fisher, Susan; Williams, Evan; Szakal, Evelin; Allen, S.; Hall, S. C.; Hazen, Terry; Witkowska, H. E.; Jin, Jiming; Glaeser, Robert; Biggin, Mark
Interfacing Capillary Electrophoresis and 2D-Infrared Spectroscopy for High Throughput Proteomics
and parameters defining the wettability of the substrate plate such as buffer conductivity, applied electric efficiency, the sample therefore needs to be concentrated onto an area while a linear motor stage is translating the substrate plate beneath. A high analyte area Optical
Rosso, Lula
Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center
The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...
Vokoun, Matthew R. (Matthew Richard)
High-throughput genomic analysis of virulence and resistance mechanisms among microbial pathogens
al. (2010). Evolution of MRSA during hospital transmissionphylogenetic tree CA-MRSA isolates and the reference strainand antibiotic resistance costs by MRSA. The ISME journal 4,
Tewhey, Ryan Stephen
E-Print Network 3.0 - analyzing high-throughput sequencing Sample...
and managed by Collection: Renewable Energy 2 Applying model-based methods to analyze genomics data Zhaohui Qin Summary: tools to extract scientific insights from massive and noisy...
Characterization and High Throughput Analysis of Metal Hydrides for Hydrogen Storage
Metal Hydrides for Hydrogen Storage by Steven James BarceloMetal Hydrides for Hydrogen Storage by Steven James BarceloCo-chair Efficient hydrogen storage is required for fuel
Barcelo, Steven James
Characterization and High Throughput Analysis of Metal Hydrides for Hydrogen Storage.
??Efficient hydrogen storage is required for fuel cell vehicles to be competitive with those driven by internal combustion engines. Current methods of storage such as� (more)
High Throughput Ultralong (20 cm) Nanowire Fabrication Using a Wafer-Scale Nanograting Template
-gu, Daejeon, 305-701, Republic of Korea LG Innotek Components & Materials R&D Center, 55 Hanyang Daehak actively explored as promising nanostructured materials for high performance flexible electronics (centimeter- long) nanowires are highly attractive from the perspective of electronic performance, device
MCAM: Multiple Clustering Analysis Methodology for Deriving Hypotheses and Insights from High-Throughput Proteomic Datasets
Advances in proteomic technologies continue to substantially accelerate capability for generating experimental data on protein levels, states, and activities in biological samples. For example, studies on receptor tyrosine ...
Naegle, Kristen Marie
Air-stable ink for scalable, high-throughput layer deposition
A method for producing and depositing air-stable, easily decomposable, vulcanized ink on any of a wide range of substrates is disclosed. The ink enables high-volume production of optoelectronic and/or electronic devices using scalable production methods, such as roll-to-roll transfer, fast rolling processes, and the like.
Weil, Benjamin D; Connor, Stephen T; Cui, Yi
Low-damage high-throughput grazing-angle sputter deposition on graphene
Despite the prevalence of sputter deposition in the microelectronics industry, it has seen very limited applications for graphene electronics. In this letter, we report systematic investigation of the sputtering induced damages in graphene and identify the energetic sputtering gas neutrals as the primary cause of graphene disorder. We further demonstrate a grazing-incidence sputtering configuration that strongly suppresses fast neutral bombardment and retains graphene structure integrity, creating considerably lower damage than electron-beam evaporation. Such sputtering technique yields fully covered, smooth thin dielectric films, highlighting its potential for contact metals, gate oxides, and tunnel barriers fabrication in graphene device applications.
Chen, C.-T.; Gajek, M.; Raoux, S. [IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598 (United States); Casu, E. A. [IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598 (United States); Politecnico di Torino, Turin 10129 (Italy)
Development and Application of a High Throughput Methodology to Characterize and Formulate Protein-Based Therapeutics
simultaneously, including UV absorption, light scattering, and near- and far- UV CD by employing a multimodal spectrometer (Chapter 2). Fluorescence spectral data are also collected on the same instrument although not simultaneously. The method is developed...
Hu, Lei
High-Throughput Methodology for Discovery of Metal-Organic Frameworks with a High
of California, Berkeley Lily Ackerman and Thomas R. Boussie Symyx Technologies, Inc. #12;A Tetrazolate
High-Throughput In Situ Parametric Studies of Cytochrome P450 Catalysis
of data quality in pharmaceutical industry, J Chromatogr Agenerally useful to pharmaceutical industries to facilitateimportance to the pharmaceutical industry in the metabolic
Traylor, Matthew John
Antibody-functionalized nanoporous surfaces enable high throughput specific cell capture
Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics ...
Mittal, Sukant
Estimating enrichment of repetitive elements from high-throughput sequence data
We describe computational methods for analysis of repetitive elements from short-read sequencing data, and apply them to study histone modifications associated with the repetitive elements in human and mouse cells. Our ...
Luquette, Lovelace J.
PVD synthesis and high-throughput property characterization of Ni?Fe?Cr alloy libraries
Three methods of alloy library synthesis, thick-layer deposition followed by interdiffusion, composition-spread codeposition and electron-beam melting of thick deposited layers, have been applied to Ni-Fe-Cr ternary and Ni-Cr binary alloys. Structural XRD mapping and mechanical characterization by means of nanoindentation have been used to characterize the properties of the libraries. The library synthesis methods are compared from the point of view of the structural and mechanical information they can provide.
Rar, A.; Frafjord, J.J.; Fowlkes, Jason D.; Specht, E.D.; Rack, P.D.; Santella, M.L.; Bei, H.; George, E.P.; Pharr, G.M. (Tennessee-K); (Tennessee-K); (ORNL)
High throughput 3D optical microscopy : from image cytometry to endomicroscopy
Optical microscopy is an imaging technique that allows morphological mapping of intracellular structures with submicron resolution. More importantly, optical microscopy is a technique that can readily provide images with ...
Choi, Heejin
SUPPLEMENTAL INFORMATION Treatability of Complex Effluents in High-Throughput and Bench Scale Microbial
. The efficiency was calculated using only recovered hydrogen and combined hydrogen and methane, using the heat of combustion to calculate the energy contained in the gas. Figure S13. Open circuit gas production and COD
High throughput parallel backside contacting and periodic texturing for high-efficiency solar cells
Disclosed are configurations of long-range ordered features of solar cell materials, and methods for forming same. Some features include electrical access openings through a backing layer to a photovoltaic material in the solar cell. Some features include textured features disposed adjacent a surface of a solar cell material. Typically the long-range ordered features are formed by ablating the solar cell material with a laser interference pattern from at least two laser beams.
Daniel, Claus; Blue, Craig A.; Ott, Ronald D.
Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide
Strength of Monolayer Graphene Science 2008 321, 385-388. 5.Novoselov, K. S. The rise of graphene Nature 2007 6 183-191.A. Thermal properties of graphene and nanostructured carbon
High throughput low power decoder architectures for low density parity check codes
. The dynamic scheme performs X soft iterations, then a parity checker cHT that computes the number of parity checks in error. Based on cHT value, the decoder decides on performing either soft iterations or a hard iteration. The advantage of the hard iteration...
Selvarathinam, Anand Manivannan
High-throughput indentational elasticity measurements of hydrogel extracellular matrix substrates
their surroundings, including the extracellular matrix ECM and the solid-state biopolymeric scaffold to which cells
Kumar, Sanjay
. Corresponding author email: firstname.lastname@example.com ABSTRACT Data-driven metric adaptation is proposed descent method [7]. 2. METHOD MATRIX LEARNING As input q-dimensional row vectors x R1�?q are as- sumed
Biehl, Michael
An ultra-high throughput mutational spectrometer for human genetic diagnostics
Discovering the genetic causes of common diseases may require scanning for mutations in all of the genes in a million people, a significant undertaking. Such discoveries would revolutionize biotechnology, potentially ...
Forest, Craig Richard, 1978-
The Development of a High-throughput Microdroplet Bioreactor Device for Microbial Studies
Current PCR Polymerase Chain Reaction MOS-FET Metal-Oxide-Semiconductor Field-Effect Transistor BSA Bovine Serum Albumin GFP Green Fluorescent Protein RFP Red Fluorescent Protein LED Light Emitting Diode PMT Photomultiplier Tubes...
Guzman, Adrian
Ultra-high-aspect-ratio nanofluidic channels for high-throughput biological applications
The development of micro/nanofluidics is expected to be the enabling technology for sample preparation of proteomic biosamples, which has been the bottleneck in proteomics. Most microfabricated nanofluidic channels, such ...
Mao, Pan
Geochip: A high throughput genomic tool for linking community structure to functions
soil samples from two oilfields, Daqing and Shengli, locatedall samples from the Daqing oilfield grouping together whilecommunity from the Shengli oilfield was separate (Figure 2),
Van Nostrand, Joy D.
Database Requirements for Workflow Management in a HighThroughput Genome Laboratory 1
@genome.wi.mit.edu 2 University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S constitutes an audit trail, or event history, and has much the same function as a laboratory notebook number P50 HG00098, and from the U.S. Department of Energy under contract DEFG0295ER62101. 1 #12
Bonner, Anthony
LabFlow1: a Database Benchmark for HighThroughput Workflow Management ?
@db.toronto.edu Adel Shrufi 1 email@example.com Steve Rozen 2 firstname.lastname@example.com 1 University of Toronto of workflow activity. This DBMS maintains an audit trail, or event history, that records the results of each Genome Research, grant number P50 HG00098, and from the U.S. Department of Energy under contract DEFG02
LabFlow1: a Database Benchmark for HighThroughput Workflow Management \\Lambda
University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S 1A4 2 track of workflow activity. This DBMS maintains an audit trail, or event history, that records number P50 HG00098, and from the U.S. Department of Energy under contract DEFG0295ER62101. #12
Development of a high throughput 3D perfused liver tissue bioreactor
This thesis describes the development of a device designed for culturing liver tissue in a 3D perfused environment. Cells form tissue inside miniature channels of a scaffold, and the tissue is perfused with culture medium ...
Inman, Samuel Walker
Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray
Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with ...
Hook, Andrew L.
Inferring interactions, expression programs and regulatory networks from high throughput biological data
(cont.) For the networks level I present an algorithm that efficiently combines complementary large-scale expression and protein-DNA binding data to discover co-regulated modules of genes. This algorithm is extended so ...
Bar-Joseph, Ziv, 1971-
Development of a high-throughput fermentation assay using colorimetric measurement of gas production.
??Typical methods for determining ethanol production from biomass feedstocks involve the use of High Performance Liquid Chromatography (HPLC) or Gas Chromatography (GC). Such methods require� (more)
Bly, Steven
ComparativeComparative InteractomicsInteractomics comparative genomics of high throughput data
of quality of expert curation (to use as source or reference) and most prolific HTP data (complex mean absence of co- complex membership #12;Estimating absence of interactions from HTP dataEstimating absence of interactions from HTP data --> yeast; what do we call an absence of interaction data> yeast
Utrecht, Universiteit
High-throughput approaches to sourcing of human hepatocytes for cell-based therapies
Chronic liver disease affects more than 500 million people worldwide. The only therapy shown to directly prevent mortality is organ transplantation. However, there is growing discrepancy between supply and demand of ...
Shan, Jing (Jing Meghan)
A Warm Near-Infrared High-Resolution Spectrograph with Very High Throughput (WINERED)
WINERED is a newly built high-efficiency (throughput$ > 25-30\\%$) and high-resolution spectrograph customized for short NIR bands at 0.9-1.35 ${\\rm \\mu}$m. WINERED is equipped with ambient temperature optics and a cryogenic camera using a 1.7 ${\\rm \\mu}$m cut-off HgCdTe HAWAII-2RG array detector. WINERED has two grating modes: one with a conventional reflective echelle grating (R$\\sim$28,300), which covers 0.9-1.35 $\\mu$m simultaneously, the other with ZnSe or ZnS immersion grating (R$\\sim$100,000). We have completed the development of WINERED except for the immersion grating, and started engineering and science observations at the Nasmyth platform of the 1.3 m Araki Telescope at Koyama Astronomical Observatory of Kyoto-Sangyo University in Japan. We confirmed that the spectral resolution ($R\\sim$ 28,300) and the throughput ($>$ 40\\% w/o telescope/atmosphere/array QE) meet our specifications. We measured ambient thermal backgrounds (e.g., 0.06 ${\\rm [e^{-}/sec/pixel]}$ at 287 K), which are roughly consistent ...
Kondo, Sohei; Kobayashi, Naoto; Yasui, Chikako; Mito, Hiroyuki; Fukue, Kei; Nakanishi, Kenshi; Kawanishi, Takafumi; Nakaoka, Tetsuya; Otsubo, Shogo; Kinoshita, Masaomi; Kitano, Ayaka; Hamano, Satoshi; Mizumoto, Misaki; Yamamoto, Ryo; Izumi, Natsuko; Matsunaga, Noriyuki; Kawakita, Hideyo
ORIGINAL PAPER The RABiT: high-throughput technology for assessing global DSB
. Turner · P. Sharma · J. R. Perrier · A. Bertucci · L. Smilenov · G. Johnson · M. Taveras · D. J. Brenner, and it has a H. C. Turner (&) Á P. Sharma Á J. R. Perrier Á A. Bertucci Á L. Smilenov Á G. Johnson Á M
Brenner, David Jonathan
Analysis of High-Throughput Sequencing and Annotation Strategies for Phage Genomes
Background: Bacterial viruses (phages) play a critical role in shaping microbial populations as they influence both host mortality and horizontal gene transfer. As such, they have a significant impact on local and global ...
Chisholm, Sallie (Penny)
The First Extrasolar Planet Discovered with a New Generation High Throughput Doppler Instrument
We report the detection of the first extrasolar planet, ET-1 (HD 102195b), using the Exoplanet Tracker (ET), a new generation Doppler instrument. The planet orbits HD 102195, a young star with solar metallicity that may be part of the local association. The planet imparts radial velocity variability to the star with a semiamplitude of $63.4\\pm2.0$ m s$^{-1}$ and a period of 4.11 days. The planetary minimum mass ($m \\sin i$) is $0.488\\pm0.015$ $M_J$.
Jian Ge; Julian van Eyken; Suvrath Mahadevan; Curtis DeWitt; Stephen R. Kane; Roger Cohen; Andrew Vanden Heuvel; Scott W. Fleming; Pengcheng Guo; Gregory W. Henry; Donald P. Schneider; Lawrence W. Ramsey; Robert A. Wittenmyer; Michael Endl; William D. Cochran; Eric B. Ford; Eduardo L. Martin; Garik Israelian; Jeff Valenti; David Montes
), using the Exoplanet Tracker (ET), a new generation Doppler instrument. The planet orbits HD 102195, a young star with solar metallicity that may be part of the local association. The planet imparts radial
Complutense de Madrid, Universidad
Scalable Computational Methods for the Analysis of High-Throughput Biological Data
This primary focus of this research project is elucidating genetic regulatory mechanisms that control an organism�?¢�?�?�?�?s responses to low-dose ionizing radiation. Although low doses (at most ten centigrays) are not lethal to humans, they elicit a highly complex physiological response, with the ultimate outcome in terms of risk to human health unknown. The tools of molecular biology and computational science will be harnessed to study coordinated changes in gene expression that orchestrate the mechanisms a cell uses to manage the radiation stimulus. High performance implementations of novel algorithms that exploit the principles of fixed-parameter tractability will be used to extract gene sets suggestive of co-regulation. Genomic mining will be performed to scrutinize, winnow and highlight the most promising gene sets for more detailed investigation. The overall goal is to increase our understanding of the health risks associated with exposures to low levels of radiation.
Langston, Michael A.
Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping
. Capecchi4,5 , Charles Keller3* 1 Scientific Computing and Imaging Institute, University of Utah, Salt Lake of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America, 3 Department of Cellular Genetics, University of Utah, Salt Lake City, Utah, United States of America, 5 Howard Hughes Medical
Capecchi, Mario R.
Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine
The ability to accurately detect and quantify biological molecules in complex mixtures is crucial in basic research as well as in clinical settings. Advancements in genetic analysis, molecular diagnostics, and patient-tailored ...
Chapin, Stephen Clifford
High-throughput Microfluidics and Ultrafast Optics for in Vivo Compound/Genetic Discoveries
Therapeutic treatment of spinal cord injuries, brain trauma, stroke, and neurodegenerative diseases will greatly benefit from the discovery of compounds that enhance neuronal regeneration following injury. We previously ...
Rohde, Christopher Benjamin
High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling
The cellular microenvironment is remarkably complex. In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant ...
King, Kevin R. (Kevin Robert), 1976-
High throughput lessons from the LHC experience.Johnston.TNC2013
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Use of high-throughput mass spectrometry to elucidate host pathogen
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Algorithms and tools for high-throughput geometry-based analysis of
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High-throughput Characterization of Porous Materials Using Graphics Processing Units
A.E. ; Purcell, T. Computer Graphics Forum 2007, 26(1), 80-of Porous Materials Using Graphics Processing Units Jihanof Porous Materials Using Graphics Processing Units Jihan
Kim, Jihan
High-Throughput, High-Precision Hot Testing Tool for High-Brightness
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High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D
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High-Throughput Methodology for Discovery of Metal-Organic Frameworks with
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High-Throughput Program for the Discovery of NOx Reduction Catalysts |
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Biochemical & Thermochemical High Throughput Characterization of Feedstocks Presentation for BETO 2015 Project Peer Review
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Biochemical & Thermochemical High Throughput Characterization of Feedstocks for BETO 2015 Project Peer Review
An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput
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Bayesian Model Selection for High-dimensional High-throughput Data
LIST OF TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi CHAPTER I INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . 1 II... BAYESIAN HYPOTHESIS TESTING USING TEST STATISTICS 7 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.3 Bayes? factors based on test statistics: testing...
Joshi, Adarsh
both ends (typically a GPS- based clock, or comparable). These tools are OWAMP 22 and HADES 23. Throughput is measured with BWCTL (a wrapper and controller for iperf throughput...
Radiation Tolerant Programmable Power Supply for the LHC Beam Screen Heaters
For the next LHC run, it is required to install 200W of heating capacity per LHC beam screen heater to regenerate the beam screen by desorption of gas trapped on its walls. In the LHC, there are 272 beam screen heaters and the associated electronics limit presently the heating capacity to 25W. Those electronics are, for the most part, installed inside the LHC tunnel and exposed to its radiation environment. This paper describes the development of a new programmable power supply card that will be integrated into the existing LHC radiation tolerant electronic infrastructure used by the cryogenic system. Radiation tests were undertaken to qualify a power switch capable of coping with the 230Vrms grid voltage and an analog signal multiplexer; these components are required respectively for satisfying the higher power requirements and for reducing the overall cost by using a single analog to digital converter to sample all the signals.
Casas, J
Process of Integrating Screening and Detailed Risk-based Modeling Analyses to Ensure Consistent and Scientifically Defensible Results
To support cleanup and closure of these tanks, modeling is performed to understand and predict potential impacts to human health and the environment. Pacific Northwest National Laboratory developed a screening tool for the United States Department of Energy, Office of River Protection that estimates the long-term human health risk, from a strategic planning perspective, posed by potential tank releases to the environment. This tool is being conditioned to more detailed model analyses to ensure consistency between studies and to provide scientific defensibility. Once the conditioning is complete, the system will be used to screen alternative cleanup and closure strategies. The integration of screening and detailed models provides consistent analyses, efficiencies in resources, and positive feedback between the various modeling groups. This approach of conditioning a screening methodology to more detailed analyses provides decision-makers with timely and defensible information and increases confidence in the results on the part of clients, regulators, and stakeholders.
Buck, John W.; McDonald, John P.; Taira, Randal Y.
Impact of Screening on Behavior During Storage and Cost of Ground Small-Diameter Pine Trees: A Case Study
Whole comminuted trees are known to self-heat and undergo quality changes during storage. Trommel screening after grinding is a process that removes fines from the screened material and removes a large proportion of high-ash, high-nutrient material. In this study, the trade-off between an increase in preprocessing cost from trommel screening and an increase in quality of the screened material was examined. Fresh lodgepole pine (Pinus contorta) was comminuted using a drum grinder with a 10-cm screen, and the resulting material was distributed into separate fines and overs piles. A third pile of unscreened material, the unsorted pile, was also examined. The three piles exhibited different characteristics during a 6-week storage period. The overs pile was much slower to heat. The overs pile reached a maximum temperature of 56.88 degrees C, which was lower than the maximum reached by the other two piles (65.98 degrees C and 63.48 degrees C for the unsorted and fines, respectively). The overs also cooled faster and dried to a more uniform moisture content and had a lower ash content than the other two piles. Both piles of sorted material exhibited improved airflow and more drying than the unsorted material. Looking at supply system costs from preprocessing through in-feed into thermochemical conversion, this study found that trommel screening reduced system costs by over $3.50 per dry matter ton and stabilized material during storage.
Erin Searcy; Brad D Blackwelder; Mark E Delwiche; Allison E Ray; Kevin L Kenney
Screening analysis of solar thermochemical hydrogen concepts.
A screening analysis was performed to identify concentrating solar power (CSP) concepts that produce hydrogen with the highest efficiency. Several CSP concepts were identified that have the potential to be much more efficient than today's low-temperature electrolysis technology. They combine a central receiver or dish with either a thermochemical cycle or high-temperature electrolyzer that operate at temperatures >600 C. The solar-to-hydrogen efficiencies of the best central receiver concepts exceed 20%, significantly better than the 14% value predicted for low-temperature electrolysis.
Diver, Richard B., Jr.; Kolb, Gregory J.
Construction Worker Screening Projects | Department of Energy
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Plasma Screen Floating Mount - Energy Innovation Portal
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Electron screening effect on stellar thermonuclear fusion
We study the impact of plasma correlation effects on nonresonant thermonuclear reactions for various stellar objects, namely in the liquid envelopes of neutron stars, and the interiors of white dwarfs, low-mass stars, and substellar objects. We examine in particular the effect of electron screening on the enhancement of thermonuclear reactions in dense plasmas within and beyond the linear mixing rule approximation as well as the corrections due to quantum effects at high density. In addition, we examine some recent unconventional (Yukawa-potential and "quantum-tail") theoretical results on stellar thermonuclear fusions and show that these scenarios do not apply to stellar conditions.
Potekhin, A Y
Development of the Roll type Incremental Micro Pattern Imprint System for Large Area Pattern Replication
precision and good quality at a low-cost and high- throughput way. Among them, Micro- or Nano- structure lithography (NIL) was considered widely as the potential high-throughput, high-resolution and low-cost pattern replication process, which is one the key process in the fabrication of flexible displays. Tests
Final Report - Phylogenomic tools and web resources for the Systems Biology Knowledgebase
The major advance during this last reporting period (8/15/12 to present) is our release of data on the PhyloFacts website: phylogenetic trees, multiple sequence alignments and other data for protein families are now available for download from http://phylogenomics.berkeley.edu/data/. This project as a whole aimed to develop high-throughput functional annotation systems that exploit information from protein 3D structure and evolution to provide highly precise inferences of various aspects of gene function, including molecular function, biological process, pathway association, Pfam domains, cellular localization and so on. We accomplished these aims by developing and testing different systems on a database of protein family trees: the PhyloFacts Phylogenomic Encyclopedia (at http://phylogenomics.berkeley.edu/phylofacts/ ).
Sjolander, Kimmen
Western Research Institute (WRI) initiated exploratory work towards the development of new field screening methodology and a test kit to measure halogenated volatile organic compounds (VOCs) in the field. Heated diode and corona discharge sensors are commonly used to detect leaks of refrigerants from air conditioners, freezers, and refrigerators. They are both selective to the presence of carbon-halogen bonds. Commercially available heated diode and corona discharge leak detectors were procured and evaluated for halogenated VOC response. The units were modified to provide a digital readout of signal related to VOC concentration. Sensor response was evaluated with carbon tetrachloride and tetrachloroethylene (perchloroethylene, PCE), which represent halogenated VOCs with and without double bonds. The response characteristics were determined for the VOCs directly in headspace in Tedlar bag containers. Quantitation limits in air were estimated. Potential interferences from volatile hydrocarbons, such as toluene and heptane, were evaluated. The effect of humidity was studied also. The performance of the new devices was evaluated in the laboratory by spiking soil samples and monitoring headspace for halogenated VOCs. A draft concept of the steps for a new analytical method was outlined. The results of the first year effort show that both devices show potential utility for future analytical method development work towards the goal of developing a portable test kit for screening halogenated VOCs in the field.
John F. Schabron; Joseph F. Rovani Jr.; Theresa M. Bomstad
Non-equilibrium thermodynamics of gravitational screens
We study the Einstein gravity equations projected on a timelike surface, which represents the time evolution of what we call a gravitational screen. We show that such a screen possesses a surface tension and an internal energy, and that the Einstein equations reduce to the thermodynamic equations of a viscous bubble. We also provide a complete dictionary between gravitational and thermodynamical variables. In the non-viscous cases there are three thermodynamic equations which characterise a bubble dynamics: These are the first law, the Marangoni flow equation and the Young-Laplace equation. In all three equations the surface tension plays a central role: In the first law it appears as a work term per unit area, in the Marangoni flow its gradient drives a force, and in the Young-Laplace equation it contributes to a pressure proportional to the surface curvature. The gravity equations appear as a natural generalization of these bubble equations when the bubble itself is viscous and dynamical. In particular, it shows that the mechanism of entropy production for the viscous bubble is mapped onto the production of gravitational waves. We also review the relationship between surface tension and temperature, and discuss the usual black-hole thermodynamics from this point of view.
Laurent Freidel; Yuki Yokokura
Strong plasma screening in thermonuclear reactions: Electron drop model
We analyze enhancement of thermonuclear fusion reactions due to strong plasma screening in dense matter using a simple electron drop model. The model assumes fusion in a potential that is screened by an effective electron cloud around colliding nuclei (extended Salpeter ion-sphere model). We calculate the mean field screened Coulomb potentials for atomic nuclei with equal and nonequal charges, appropriate astrophysical S factors, and enhancement factors of reaction rates. As a byproduct, we study analytic behavior of the screening potential at small separations between the reactants. In this model, astrophysical S factors depend not only on nuclear physics but on plasma screening as well. The enhancement factors are in good agreement with calculations by other methods. This allows us to formulate the combined, pure analytic model of strong plasma screening in thermonuclear reactions. The results can be useful for simulating nuclear burning in white dwarfs and neutron stars.
Kravchuk, P A
P. A. Kravchuk; D. G. Yakovlev
Western Research Institute (WRI) has developed new methodology and a test kit to screen soil or water samples for halogenated volatile organic compounds (HVOCs) in the field. The technology has been designated the X-Wand{trademark} screening tool. The new device uses a heated diode sensor that is commonly used to detect leaks of refrigerants from air conditioners, freezers, and refrigerators. This sensor is selective to halogens. It does not respond to volatile aromatic hydrocarbons, such as those in gasoline, and it is not affected by high humidity. In the current work, the heated diode leak detectors were modified further to provide units with rapid response and enhanced sensitivity. The limit of detection for trichloroethylene TCE in air is 0.1 mg/m{sup 3} (S/N = 2). The response to other HVOCS relative to TCE is similar. Variability between sensors and changes in a particular sensor over time can be compensated for by normalizing sensor readings to a maximum sensor reading at 1,000 mg/m{sup 3} TCE. The soil TCE screening method was expanded to include application to water samples. Assuming complete vaporization, the detection limit for TCE in soil is about 1 ug/kg (ppb) for a 25-g sample in an 8-oz jar. The detection limit for TCE in water is about 1 ug/L (ppb) for a 25-mL sample in an 8-oz jar. This is comparable to quantitation limits of EPA GC/MS laboratory methods. A draft ASTM method for screening TCE contaminated soils using a heated diode sensor was successfully submitted for concurrent main committee and subcommittee balloting in ASTM Committee D 34 on Waste Management. The method was approved as ASTM D 7203-05, Standard Test Method for Screening Trichloroethylene (TCE)-Contaminated Soil Using a Heated Diode Sensor.
John F. Schabron; Susan S. Sorini; Joseph F. Rovani Jr
Coal storage hopper with vibrating-screen agitator
The present invention is directed to a vibrating screen agitator in a coal storage hopper for assuring the uniform feed of coal having sufficient moisture content to effect agglomeration and bridging thereof in the coal hopper from the latter onto a conveyer mechanism. The vibrating scrren agitator is provided by a plurality of transversely oriented and vertically spaced apart screens in the storage hopper with a plurality of vertically oriented rods attached to the screens. The rods are vibrated to effect the vibration of the screens and the breaking up of agglomerates in the coal which might impede the uniform flow of the coal from the hopper onto a conveyer.
Daw, C.S.; Lackey, M.E.; Sy, R.L.
abuse screening tool: Topics by E-print Network
(HPV Druzdzel, Marek J. 3 The Feasibility of Tablet Computer Screening for Opioid Abuse in the Emergency Department University of California eScholarship Repository...
abuse screening tools: Topics by E-print Network
(HUD's) 2002 Energy Action Plan includes an initiative to promote the use of combined heat and power (CHP) in multifamily housing. This 2009 guide "Feasibility Screening for...
Electric and Magnetic Screening Masses around the Deconfinement Transition
We report on the status of our study of gluon propagators and screening masses around the de- confining transition for pure SU(2) gauge theory in Landau gauge.
Attilio Cucchieri; Tereza Mendes
Combining in vivo and in silico screening for protein stability
Implications for the Protein Folding Code". Biochemistry 44(Proteolytic selection for protein folding using filamentousin vivo screening for protein folding and increased protein
Barakat, Nora Hisham
Screening of Electrode Materials & Cell Chemistries and Streamlining...
of Electrodes Screening of Electrode Materials & Cell Chemistries and Streamlining Optimization of Electrodes 2012 DOE Hydrogen and Fuel Cells Program and Vehicle...
of Electrodes Screening of Electrode Materials & Cell Chemistries and Streamlining Optimization of Electrodes 2011 DOE Hydrogen and Fuel Cells Program, and Vehicle...
Yakima River Basin Phase II Fish Screen Evaluations, 2001.
In the summer and fall of 2001 the Pacific Northwest National Laboratory (PNNL) evaluated 23 Phase II fish screen sites in the Yakima River Basin as part of a multi-year study for the Bonneville Power Administration (BPA) on the effectiveness of fish screening devices. Data were collected to determine if velocities in front of the screens and in the bypasses met current National Marine Fisheries Service (NMFS) criteria to promote safe and timely fish passage and whether bypass outfall conditions allowed fish to safely return to the river. Based on our studies in 2001, we concluded that: in general, water velocity conditions at the screen sites met fish passage criteria set forth by the NMFS; most facilities efficiently protected juvenile fish from entrainment, impingement, or migration delay; automated cleaning brushes generally functioned properly; chains and other moving parts were well greased and operative; and removal of sediment build-up and accumulated leafy and woody debris are areas that continue to improve. Continued periodic screen evaluations will increase the effectiveness of screen operation and maintenance practices by confirming the effectiveness (or ineffectiveness) of screen operating procedures at individual sites. Where procedures are being followed and problems still occur, evaluation results can be used to suggest means to better protect fish at screening facilities. There has been a progressive improvement in the maintenance and effectiveness of fish screen facilities in the Yakima River Basin during the last several years, in part, as a result of regular screen evaluations and the rapid feedback of information necessary to improve operations and design of these important fish protection devices. Continued periodic screen evaluations will increase the effectiveness of screen operation and maintenance practices by confirming the effectiveness (or ineffectiveness) of screen operating procedures at individual sites. Where procedures are being followed and problems still occur, evaluation results can be used to suggest means to better protect fish at screening facilities. There has been a progressive improvement in the maintenance and effectiveness of fish screen facilities in the Yakima River Basin during the last several years, in part, as a result of regular screen evaluations and the rapid feedback of information necessary to improve operations and design of these important fish protection devices.
Carter, J.A.; McMichael, Geoffrey A.; Chamness, M.A.
Western Research Institute (WRI) is continuing work toward the development of new screening methodology and a test kit to measure halogenated volatile organic compounds (VOCs) in the field. Heated diode and corona discharge sensors are commonly used to detect leaks of refrigerants from air conditioners, freezers, and refrigerators. They are both selective to the presence of halogens. In prior work, the devices were tested for response to carbon tetrachloride, heptane, toluene, and water vapors. In the current work, sensor response was evaluated with sixteen halogenated VOCs relative to carbon tetrachloride. The results show that the response of the various chlorinated VOCs is within an order of magnitude of the response to carbon tetrachloride for each of the sensors. Thus, for field screening a single response factor can be used. Both types of leak detectors are being further modified to provide an on-board LCD signal readout, which is related to VOC concentration. The units will be fully portable and will operate with 115-V line or battery power. Signal background, noise level, and response data on the Bacharach heated diode detector and the TIF corona discharge detector show that when the response curves are plotted against the log of concentration, the plot is linear to the upper limit for the particular unit, with some curvature at lower levels. When response is plotted directly against concentration, the response is linear at the low end and is curved at the high end. The dynamic ranges for carbon tetrachloride of the two devices from the lower detection limit (S/N=2) to signal saturation are 4-850 vapor parts per million (vppm) for the corona discharge unit and 0.01-70 vppm for the heated diode unit. Additional circuit modifications are being made to lower the detection limit and increase the dynamic response range of the corona discharge unit. The results indicate that both devices show potential utility for future analytical method development work toward the goal of developing a portable test kit for screening halogenated VOCs in the field.
John F. Schabron; Joseph F. Rovani, Jr.; Theresa M. Bomstad
Apparatus and method for radioactive waste screening
An apparatus and method relating to screening radioactive waste are disclosed for ensuring that at least one calculated parameter for the measurement data of a sample falls within a range between an upper limit and a lower limit prior to the sample being packaged for disposal. The apparatus includes a radiation detector configured for detecting radioactivity and radionuclide content of the of the sample of radioactive waste and generating measurement data in response thereto, and a collimator including at least one aperture to direct a field of view of the radiation detector. The method includes measuring a radioactive content of a sample, and calculating one or more parameters from the radioactive content of the sample.
Akers, Douglas W.; Roybal, Lyle G.; Salomon, Hopi; Williams, Charles Leroy
Maximum screening fields of superconducting multilayer structures
It is shown that a multilayer comprised of alternating thin superconducting and insulating layers on a thick substrate can fully screen the applied magnetic field exceeding the superheating fields $H_s$ of both the superconducting layers and the substrate, the maximum Meissner field is achieved at an optimum multilayer thickness. For instance, a dirty layer of thickness $\\sim 0.1\\; \\mu$m at the Nb surface could increase $H_s\\simeq 240$ mT of a clean Nb up to $H_s\\simeq 290$ mT. Optimized multilayers of Nb$_3$Sn, NbN, some of the iron pnictides, or alloyed Nb deposited onto the surface of the Nb resonator cavities could potentially double the rf breakdown field, pushing the peak accelerating electric fields above 100 MV/m while protecting the cavity from dendritic thermomagnetic avalanches caused by local penetration of vortices.
Gurevich, Alex
Cooling air duct and screen arrangement for an air cooled engine
This patent describes a cooling air duct and screen arrangement for an air cooled engine which includes an improved cooling air system for ensuring a supply of relatively clean air for ingestion by the cooling shroud, which consists of: a vertical transverse baffle mounted to the frame and fitting closely against a forward top portion of the shroud and having an edge shaped complementary to and disposed at least closely adjacent the hood. An air duct is mounted to the frame and has an upright rear wall seated against the front of the shroud in an area surrounding the inlet. The air duct further has an upright front wall and a connecting wall joining respective side and bottom edges of the front and rear walls and cooperating therewith to define an upwardly facing opening. A screen is located forwardly of the baffle and has a top and front joined by opposite sides with the top and opposite sides having rear edges mounted against the baffle and with the opposite sides and front having bottom edges engaged with the air duct about the upwardly facing opening wherein the screen is mounted solely to the baffle by connection means including a vertical guide means provided on the forward side of the baffle and flange means formed on the screen and being vertically slidably received in the guide means.
Hoch, J.J.; Stricker, D.K.
Screened thermonuclear reactions and predictive stellar evolution of detached double-lined eclipsing binaries
The low energy fusion cross sections of charged-particle nuclear reactions (and the respective reaction rates) in stellar plasmas are enhanced due to plasma screening effects. We study the impact of those effects on predictive stellar evolution simulations for detached double-lined eclipsing binaries. We follow the evolution of binary systems (pre-main sequence or main sequence stars) with precisely determined radii and masses from 1.1Mo to 23Mo (from their birth until their present state). The results indicate that all the discrepancies between the screened and unscreened models (in terms of luminosity, stellar radius, and effective temperature) are within the observational uncertainties. Moreover, no nucleosynthetic or compositional variation was found due to screening corrections. Therefore all thermonuclear screening effects on the charged-particle nuclear reactions that occur in the binary stars considered in this work (from their birth until their present state) can be totally disregarded. In other words, all relevant charged-particle nuclear reactions can be safely assumed to take place in a vacuum, thus simplifying and accelerating the simulation processes.
Theodore Liolios; Theocharis Kosmas
Conservation Screening Curves to Compare Efficiency Investments to Power Plants
methodology to compare supply and demand-side resources. The screening curve approach supplements with load curve approach supplements with load shape information the data contained in a supply curve of conservedLBL-27286 Conservation Screening Curves to Compare Efficiency Investments to Power Plants Jonathan
Environmental Screening and Evaluation of Energy-using Products
allergy screen test: Topics by E-print Network
allergy screen test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 LATEX ALLERGY SCREENING...
Results of the material screening program of the NEXT experiment
The 'Neutrino Experiment with a Xenon TPC (NEXT)', intended to investigate neutrinoless double beta decay, requires extremely low background levels. An extensive material screening and selection process to assess the radioactivity of components is underway combining several techniques, including germanium gamma-ray spectrometry performed at the Canfranc Underground Laboratory; recent results of this material screening program are presented here.
T. Dafni; V. Alvarez; I. Bandac; A. Bettini; F. I. G. M. Borges; M. Camargo; S. Carcel; S. Cebrian; A. Cervera; C. A. N. Conde; J. Diaz; R. Esteve; L. M. P. Fernandes; M. Fernandez; P. Ferrario; A. L. Ferreira; E. D. C. Freitas; V. M. Gehman; A. Goldschmidt; H. Gomez; J. J. Gomez-Cadenas; D. Gonzalez-Diaz; R. M. Gutierrez; J. Hauptman; J. A. Hernando Morata; D. C. Herrera; F. J. Iguaz; I. G. Irastorza; L. Labarga; A. Laing; I. Liubarsky; D. Lorca; M. Losada; G. Luzon; A. Mari; J. Martin-Albo; A. Martinez; G. Martinez-Lema; T. Miller; F. Monrabal; M. Monserrate; C. M. B. Monteiro; F. J. Mora; L. M. Moutinho; J. Munoz Vidal; M. Nebot-Guinot; D. Nygren; C. A. B. Oliveira; J. Perez; J. L. Perez Aparicio; J. Renner; L. Ripoll; A. Rodriguez; J. Rodriguez; F. P. Santos; J. M. F. dos Santos; L. Segui; L. Serra; D. Shuman; A. Simon; C. Sofka; M. Sorel; J. F. Toledo; J. Torrent; Z. Tsamalaidze; J. F. C. A. Veloso; J. A. Villar; R. C. Webb; J. T. White; N. Yahlali
Lead Screening for NH Soils: Minimizing Health Risks
family. On your soil test report, if the lead screening levels are elevated, you will receive in populated areas include the use of lead paint around homes (pre- 1970s), the use of lead-arsenate for pest does a "lead screening" test that indicates whether or not lead could pose a health risk for your
New Hampshire, University of
Printing Your Monthly PTA Maintenance Screen Shannon Monahan Page 1
Printing Your Monthly PTA Maintenance Screen Shannon Monahan Page 1 Office of Postdoctoral Maintenance Screen. All starting points begin before the popup menu comes up. In Internet Explorer the Orientation to Landscape, and click OK. Print as needed to either your printer or to Adobe PDF (only works
A Personal Touch -Recognizing Users Based on Touch Screen Behavior
of user interaction of personal smart phones and touch screen based devices are often shared among severalA Personal Touch - Recognizing Users Based on Touch Screen Behavior Sarah Martina Kolly Computer, there are still many open research questions concerning the basic input properties of these devices. We performed
Efficient Nanoporous Silicon Membranes for Integrated Microfluidic Separation and Sensing Systems
Nanoporous devices constitute emerging platforms for selective molecule separation and sensing, with great potential for high throughput and economy in manufacturing and operation. Acting as mass transfer diodes similar to a solid-state device based on electron conduction, conical pores are shown to have superior performance characteristics compared to traditional cylindrical pores. Such phenomena, however, remain to be exploited for molecular separation. Here we present performance results from silicon membranes created by a new synthesis technique based on interferometric lithography. This method creates millimeter sized planar arrays of uniformly tapered nanopores in silicon with pore diameter 100 nm or smaller, ideally-suited for integration into a multi-scale microfluidic processing system. Molecular transport properties of these devices are compared against state-of-the-art polycarbonate track etched (PCTE) membranes. Mass transfer rates of up to fifteen-fold greater than commercial sieve technology are obtained. Complementary results from molecular dynamics simulations on molecular transport are reported.
Ileri, N; L?tant, S E; Britten, J; Nguyen, H; Larson, C; Zaidi, S; Palazoglu, A; Faller, R; Tringe, J W; Stroeve, P
A simple transfer-optics system for an extreme-ultraviolet synchrotron beamline
Radiometric experiments often require comparatively high intensities in the extreme ultraviolet, in the microwatt range. The monochromators that provide the high throughput needed for these experiments, though, do not always allow for end stations to be switched out easily. At the National Institute of Standards and Technology Synchrotron Ultraviolet Radiation Facility, the only beamline with sufficient extreme-ultraviolet power has a multi-ton endstation, which cannot be moved. We will describe a set of transfer optics that allow the photon beam to be collimated and deflected through a port on the downstream end of the large chamber. This allowed an absolute cryogenic radiometer to be attached, with the entrance cavity underfilled. We will describe ray-tracing results and offer preliminary results of the radiometer-based throughput of the system.
Tarrio, C.; Grantham, S.; Vest, R.E.; Liu, K. [Electron and Optical Physics Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8410 (United States)
One piece microwave container screens for electrodeless lamps
A microwave powered electrodeless lamp includes an improved screen unit having mesh and solid sections with an internal reflector to reflect light into a light-transmitting chamber defined in the lamp microwave cavity by the reflector and the mesh section. A discharge envelope of a bulb is disposed in the light-transmitting chamber. Light emitted from the envelope is prevented by the reflector from entering the cavity portion bounded by the solid section of the screen. Replacing mesh material by solid metal material as part of the screen unit significantly reduces leakage of microwave energy from the lamp. The solid section has multiple compliant fingers defined therein for engaging the periphery of a flange on the waveguide unit so that a hose clamp can easily secure the screen to the assembly. Screen units of this type having different mesh section configurations can be interchanged in the lamp assembly to produce different respective illumination patterns.
Turner, Brian (Myersville, MD); Ury, Michael (Bethesda, MD)
Holographic screens in ultraviolet self-complete quantum gravity
In this paper we study the geometry and the thermodynamics of a holographic screen in the framework of the ultraviolet self-complete quantum gravity. To achieve this goal we construct a new static, neutral, non-rotating black hole metric, whose outer (event) horizon coincides with the surface of the screen. The space-time admits an extremal configuration corresponding to the minimal holographic screen and having both mass and radius equalling the Planck units. We identify this object as the space-time fundamental building block, whose interior is physically unaccessible and cannot be probed even during the Hawking evaporation terminal phase. In agreement with the holographic principle, relevant processes take place on the screen surface. The area quantization leads to a discrete mass spectrum. An analysis of the entropy shows that the minimal holographic screen can store only one byte of information while in the thermodynamic limit the area law is corrected by a logarithmic term.
Piero Nicolini; Euro Spallucci
Screening in Thermonuclear Reaction Rates in the Sun
We evaluate the effect of electrostatic screening by ions and electrons on low-Z thermonuclear reactions in the sun. We use a mean field formalism and calculate the electron density of the screening cloud using the appropriate density matrix equation of quantum statistical mechanics. Because of well understood physical effects that are included for the first time in our treatment, the calculated enhancement of reaction rates does not agree with the frequently used interpolation formulae. Our result does agree, within small uncertainties, with Salpeter's weak screening formula. If weak screening is used instead of the commonly employed screening prescription of Graboske et al., the predicted $^8$B neutrino flux is increased by 7% and the predicted chlorine rate is increased by 0.4 SNU.
Andrei V. Gruzinov; John N. Bahcall
Real-time Raman system for in vivo disease diagnosis
Raman spectroscopy has been well established as a powerful in vitro method for studying biological tissue and diagnosing disease. The recent development of efficient, high-throughput, low-background optical fiber Raman ...
Motz, Jason T.
Secure and Scalable Systems for Research Data Management�
Recent years have witnessed extraordinary advancement in the data generation capacity of research tools such as mass spectrometry, genomic sequencing, digital imaging and other high throughput technologies. This has led to an enormous increase...
Walsh, Paul
High Performance Interconnect System Design for Future Chip Multiprocessors
constraints of power and area, and provide ultra low latencies and high throughput. In this research, we explore different techniques to design high performance NOC. First, existing NOCs mostly use Dimension Order Routing (DOR) to determine the route taken...
Wang, Lei
Combinatorial screening of inorganic and organometallic materials
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.
Schultz, Peter G. (Oakland, CA); Xiang, Xiaodong (Alameda, CA); Goldwasser, Isy (Alameda, CA)
Preparation and screening of crystalline inorganic materials
Schultz, Peter G. (La Jolla, CA); Xiang, Xiaodong (Danville, CA); Goldwasser, Isy (Palo Alto, CA); Brice{hacek over (n)}o, Gabriel (Baldwin Park, CA); Sun, Xiao-Dong (Fremont, CA); Wang, Kai-An (Cupertino, CA)
Electrostatically screened, voltage-controlled electrostatic chuck
Employing an electrostatically screened, voltage-controlled electrostatic chuck particularly suited for holding wafers and masks in sub-atmospheric operations will significantly reduce the likelihood of contaminant deposition on the substrates. The electrostatic chuck includes (1) an insulator block having a outer perimeter and a planar surface adapted to support the substrate and comprising at least one electrode (typically a pair of electrodes that are embedded in the insulator block), (2) a source of voltage that is connected to the at least one electrode, (3) a support base to which the insulator block is attached, and (4) a primary electrostatic shield ring member that is positioned around the outer perimeter of the insulator block. The electrostatic chuck permits control of the voltage of the lithographic substrate; in addition, it provides electrostatic shielding of the stray electric fields issuing from the sides of the electrostatic chuck. The shielding effectively prevents electric fields from wrapping around to the upper or front surface of the substrate, thereby eliminating electrostatic particle deposition.
Klebanoff, Leonard Elliott (San Ramon, CA)
Coulomb screening in graphene with topological defects
We analyze the screening of an external Coulomb charge in gapless graphene cone, which is taken as a prototype of a topological defect. In the subcritical regime, the induced charge is calculated using both the Green's function and the Friedel sum rule. The dependence of the polarization charge on the Coulomb strength obtained from the Green's function clearly shows the effect of the conical defect and indicates that the critical charge itself depends on the sample topology. Similar analysis using the Friedel sum rule indicates that the two results agree for low values of the Coulomb charge but differ for the higher strengths, especially in the presence of the conical defect. For a given subcritical charge, the transport cross-section has a higher value in the presence of the conical defect. In the supercritical regime we show that the coefficient of the power law tail of polarization charge density can be expressed as a summation of functions which vary log periodically with the distance from the Coulomb impurity. The period of variation depends on the conical defect. In the presence of the conical defect, the Fano resonances begin to appear in the transport cross-section for a lower value of the Coulomb charge. For both sub and supercritical regime we derive the dependence of LDOS on the conical defect. The effects of generalized boundary condition on the physical observables are also discussed.
Baishali Chakraborty; Kumar S. Gupta; Siddhartha Sen
We analyze the screening of an external Coulomb charge in gapless graphene cone, which is taken as a prototype of a topological defect. In the subcritical regime, the induced charge is calculated using both the Green's function and the Friedel sum rule. The dependence of the polarization charge on the Coulomb strength obtained from the Green's function clearly shows the effect of the conical defect and indicates that the critical charge itself depends on the sample topology. Similar analysis using the Friedel sum rule indicates that the two results agree for low values of the Coulomb charge but differ for the higher strengths, especially in the presence of the conical defect. For a given subcritical charge, the transport cross-section has a higher value in the presence of the conical defect. In the supercritical regime we show that the coefficient of the power law tail of polarization charge density can be expressed as a summation of functions which vary log periodically with the distance from the Coulomb imp...
Chakraborty, Baishali; Sen, Siddhartha
Submitting a Vendor Request 1. Click on `Vendor Request' in the Oracle E-Business Suite screen
Submitting a Vendor Request 1. Click on `Vendor Request' in the Oracle E-Business Suite screen 2. Search for the vendor to make sure they're not already in the system (remember to use the wildcard % symbol to make your search more thorough). 3. If the vendor you're trying to set up does not come up
Technical background document for soil screening guidance. Review draft
The document provides the technical background behind the development of the November 1994 Soil Screening Guidance for Superfund. These documents define the Soil Screening framework, a suite of methodologies for developing Soil Screening Levels (SSLs) for 107 chemicals commonly found at Superfund sites. The document is an updated version of the background document developed in support of the September 30, 1993, draft SSL guidance (PB93-963508). The document and the Guidance is available for public comment and is currently undergoing extensive peer review. Because the guidance is still under review, it and this document should not be used until they are finalized following this rigorous technical review and public comment.
Screening model for nanowire surface-charge sensors in liquid
The conductance change of nanowire field-effect transistors is considered a highly sensitive probe for surface charge. However, Debye screening of relevant physiological liquid environments challenge device performance due to competing screening from the ionic liquid and nanowire charge carriers. We discuss this effect within Thomas-Fermi and Debye-Huckel theory and derive analytical results for cylindrical wires which can be used to estimate the sensitivity of nanowire surface-charge sensors. We study the interplay between the nanowire radius, the Thomas-Fermi and Debye screening lengths, and the length of the functionalization molecules. The analytical results are compared to finite-element calculations on a realistic geometry.
Martin H. Sorensen; Niels Asger Mortensen; Mads Brandbyge
E-Print Network 3.0 - alternative screening method Sample Search...
results for: alternative screening method Page: << < 1 2 3 4 5 > >> 1 SIGGRAPH'95 Computer Graphics Proceedings, Annual Conference Series, 1995 Artistic Screening Summary:...
E-Print Network 3.0 - attend cervical screening Sample Search...
screenings for women described... Newborns Screening for hearing loss, hypothyroidism, sickle cell disease and phenylketonuria (PKU Source: Ghajar, Afshin J. - School of...
Coalbed Methane Produced Water Screening Tool for Treatment Technology and Beneficial Use 2013 Supporting Information
Coalbed Methane Produced Water Screening Tool for Treatment Technology and Beneficial Use 2013 1 (to sustain instream #12;Coalbed Methane Produced Water Screening Tool for Treatment Technology
E-Print Network 3.0 - alternative screening devices Sample Search...
blindness, mobile devices, touch screens, multi-touch interaction... in touch screen interfaces, as seen in ... Source: Anderson, Richard - Department of Computer Science and...
E-Print Network 3.0 - applied cancer screening Sample Search...
cancer screening Search Powered by Explorit Topic List Advanced Search Sample search results for: applied cancer screening Page: << < 1 2 3 4 5 > >> 1 Summer Internship Results...
E-Print Network 3.0 - acsrb cancer screening Sample Search Results
cancer screening Search Powered by Explorit Topic List Advanced Search Sample search results for: acsrb cancer screening Page: << < 1 2 3 4 5 > >> 1 Summer Internship Results...
Stochastic dominance for project screening and selection under uncertainty
At any given moment, engineering and chemical companies have a host of projects that they are either trying to screen to advance to the next stage of research or select from for implementation. These choices could range ...
Adeyemo, Adekunle M
Former Worker Medical Screening Program 2013 Annual Report, February...
Studies have shown that individuals are more likely to stop smoking, for example, when a health care provider counsels them to do so. Similarly, the re-screening examination is an...
Screening China : China in popular geopolitics, 2000-2009.
??Looking at global box-office winners from the years 2000-2009, this paper finds that the China we encounter on the silver screen, is rarely an antagonist.� (more)
Braastad, J. Steffen
Accelerator-Driven Neutron Source for Cargo Screening
Accelerator-Driven Neutron Source for Cargo Screening 1 B.A.The design of an accelerator-driven neutron source isQuadrupole (RFQ) accelerator and a neutron production gas
FREE FILM SCREENING AND DISCUSSION Abstract from Jezebel Productions
FREE FILM SCREENING AND DISCUSSION Abstract from Jezebel Productions: "No Dinosaurs in Heaven charge: free and open to the public. THURSDAY OCTOBER 27, 2011 7:00 PM Mackey Auditorium Ruby Gerontology
de Lijser, Peter
WebThumb: Interaction Techniques for Small-Screen Browsers
205 WebThumb: Interaction Techniques for Small-Screen Browsers Jacob O. Wobbrock* , Jodi Forlizzi are not made or distributed for profit or commercial advantage and that copies bear this notice and the full
Wobbrock, Jacob O.
Rapid screening of novel nanoporous materials for carbon capture separations�
In this work the experimental results from the rapid screening and ranking of a wide range of novel adsorbents for carbon capture are presented. The samples were tested using the Zero Length Column (ZLC) method which has ...
Mangano, Enzo
Systematic quantum corrections to screening in thermonuclear fusion
We develop a series expansion of the plasma screening length away from the classical limit in powers of $\\hbar^{2}$. It is shown that the leading order quantum correction increases the screening length in solar conditions by approximately 2% while it decreases the fusion rate by approximately $ 0.34%$. We also calculate the next higher order quantum correction which turns out to be approximately 0.05%.
Shirish M. Chitanvis
Chitanvis, S M
NREL: Systems Engineering - 2013 Wind Energy Systems Engineering...
3 Wind Energy Systems Engineering Workshop Photo of a seated audience with a presenter at a podium and a projection screen in the background. Paul Veers addresses the workshop...
Automated assessment of bilateral breast volume asymmetry as a breast cancer biomarker during mammographic screening
The biological concept of bilateral symmetry as a marker of developmental stability and good health is well established. Although most individuals deviate slightly from perfect symmetry, humans are essentially considered bilaterally symmetrical. Consequently, increased fluctuating asymmetry of paired structures could be an indicator of disease. There are several published studies linking bilateral breast size asymmetry with increased breast cancer risk. These studies were based on radiologists manual measurements of breast size from mammographic images. We aim to develop a computerized technique to assess fluctuating breast volume asymmetry in screening mammograms and investigate whether it correlates with the presence of breast cancer. Using a large database of screening mammograms with known ground truth we applied automated breast region segmentation and automated breast size measurements in CC and MLO views using three well established methods. All three methods confirmed that indeed patients with breast cancer have statistically significantly higher fluctuating asymmetry of their breast volumes. However, statistically significant difference between patients with cancer and benign lesions was observed only for the MLO views. The study suggests that automated assessment of global bilateral asymmetry could serve as a breast cancer risk biomarker for women undergoing mammographic screening. Such biomarker could be used to alert radiologists or computer-assisted detection (CAD) systems to exercise increased vigilance if higher than normal cancer risk is suspected.
Williams, Alex C [ORNL; Hitt, Austin N [ORNL; Voisin, Sophie [ORNL; Tourassi, Georgia [ORNL
TouchLogger: Inferring Keystrokes On Touch Screen From Smartphone Motion
]. Electromaganetic emanations of key- boards are also studied for keylogging [8]. Touch screen smartphones have
Chen, Hao
Van der Meulen and Brandsma Februari 2007 Thermometer Screen Intercomparison in De Bilt (the
conditions during a 6- year field experiment in De Bilt (the Netherlands). The comparison comprised two versions of an aspi- rated Young screen, 4 naturally ventilated round-shaped multi-plate screens (KNMI, Vaisala, Young, Socrima), a slightly aspirated version of the KNMI screen, a synthetic Stevenson screen
Haak, Hein
Suggested guidelines for anti-islanding screening.
As increasing numbers of photovoltaic (PV) systems are connected to utility systems, distribution engineers are becoming increasingly concerned about the risk of formation of unintentional islands. Utilities desire to keep their systems secure, while not imposing unreasonable burdens on users wishing to connect PV. However, utility experience with these systems is still relatively sparse, so distribution engineers often are uncertain as to when additional protective measures, such as direct transfer trip, are needed to avoid unintentional island formation. In the absence of such certainty, utilities must err on the side of caution, which in some cases may lead to the unnecessary requirement of additional protection. The purpose of this document is to provide distribution engineers and decision makers with guidance on when additional measures or additional study may be prudent, and also on certain cases in which utilities may allow PV installations to proceed without additional study because the risk of an unintentional island is extremely low. The goal is to reduce the number of cases of unnecessary application of additional protection, while giving utilities a basis on which to request additional study in cases where it is warranted.
Ellis, Abraham; Ropp, Michael
Explosives screening on a vehicle surface
A system for detecting particles on the outer surface of a vehicle has a housing capable of being placed in a test position adjacent to, but not in contact with, a portion of the outer surface of the vehicle. An elongate sealing member is fastened to the housing along a perimeter surrounding the wall, and the elongate sealing member has a contact surface facing away from the wall to contact the outer surface of the vehicle to define a test volume when the wall is in the test position. A gas flow system has at least one gas inlet extending through the wall for providing a gas stream against the surface of the vehicle within the test volume. This gas stream, which preferably is air, dislodges particles from the surface of the vehicle covered by the housing. The gas stream exits the test volume through a gas outlet and particles in the stream are detected.
Parmeter, John E.; Brusseau, Charles A.; Davis, Jerry D.; Linker, Kevin L.; Hannum, David W.
A novel polymeric microelectrode array for highly parallel, long-term neuronal culture and stimulation
Cell-based high-throughput screening is emerging as a disruptive technology in drug discovery; however, massively parallel electrical assaying of neurons and cardiomyocites has until now been prohibitively expensive. To ...
Talei Franzesi, Giovanni
A liquid-in-glass thermometer with sub-microKelvin resolution, and its application for calorimetry
Labeling methods with optical readout are widely used to implement high throughput screens for drug discovery. However, labeling requires assay customization and does not allow examination of the reactants in their native ...
David, Robert, 1977-
Structure and function of Pseudomonas aeruginosa protein PA1324 (21170)
Northwest National Laboratory, Biological Sciences Division, Northeast Structural Genomics Consortium and Northeast Structural Genomics Consortium, Miami University, Oxford, Ohio 45056 Received 12 June 2008 aeruginosa PA1324; NMR; functional genomics; NMR high-throughput screens; protein-ligand binding; protein
Powers, Robert
Supercritical Helium Cooling of the LHC Beam Screens
The cold mass of the LHC superconducting magnets, operating in pressurised superfluid helium at 1.9 K, must be shielded from the dynamic heat loads induced by the circulating particle beams, by means of beam screens maintained at higher temperature. The beam screens are cooled between 5 and 20 K by forced flow of weakly supercritical helium, a solution which avoids two-phase flow in the long, narr ow cooling channels, but still presents a potential risk of thermohydraulic instabilities. This problem has been studied by theoretical modelling and experiments performed on a full-scale dedicated te st loop.
Hatchadourian, E; Tavian, L
Automatic TLI recognition system. Part 1: System description
This report describes an automatic target recognition system for fast screening of large amounts of multi-sensor image data, based on low-cost parallel processors. This system uses image data fusion and gives uncertainty estimates. It is relatively low cost, compact, and transportable. The software is easily enhanced to expand the system`s capabilities, and the hardware is easily expandable to increase the system`s speed. This volume gives a general description of the ATR system.
Partin, J.K.; Lassahn, G.D.; Davidson, J.R.
NETL F 451.1/1-1, Categorical Exclusion Designation Form
Madison, WI High-Throughput Study of Diffusion and Phase Transformation Kinetics of Magnesium-Based Systems... CompuTherm will perform computer modeling and simulation of...
CX-010981: Categorical Exclusion Determination | Department of...
Determination High-Throughput Study of Diffusion and Phase Transformation Kinetics of Magnesium-Based Systems... CX(s) Applied: A9 Date: 09132013 Location(s): Wisconsin...
Magnetophoretic bead trapping in a high-flowrate biological detection system.
This report contains the summary of the 'Magnetophoretic Bead Trapping in a High-Flowrate Biological Detection System' LDRD project 74795. The objective of this project is to develop a novel biodetection system for high-throughput sample analysis. The chief application of this system is in detection of very low concentrations of target molecules from a complex liquid solution containing many different constituents--some of which may interfere with identification of the target molecule. The system is also designed to handle air sampling by using an aerosol system (for instance a WESP - Wet Electro-Static Precipitator, or an impact spray system) to get air sample constituents into the liquid volume. The system described herein automatically takes the raw liquid sample, whether air converted or initially liquid matrix, and mixes in magnetic detector beads that capture the targets of interest and then performs the sample cleanup function, allowing increased sensitivity and eliminating most false positives and false negatives at a downstream detector. The surfaces of the beads can be functionalized in a variety of ways in order to maximize the number of targets to be captured and concentrated. Bacteria and viruses are captured using antibodies to surface proteins on bacterial cell walls or viral particle coats. In combination with a cell lysis or PCR (Polymerase Chain Reaction), the beads can be used as a DNA or RNA probe to capture nucleic acid patterns of interest. The sample cleanup capability of this system would allow different raw biological samples, such as blood or saliva to be analyzed for the presence of different infectious agents (e.g. smallpox or SARS). For future studies, we envision functionalizing bead surfaces to bind to chemical weapons agents, radio-isotopes, and explosives. The two main objectives of this project were to explore methods for enhancing the mixing of the capture microspheres in the sample, and to develop a novel high-throughput magnetic microsphere trap. We have developed a novel technique using the magnetic capture microspheres as 'stirrer bars' in a fluid sample to enhance target binding to the microsphere surfaces. We have also made progress in developing a polymer-MEMS electromagnet for trapping magnetic spheres in a high-flowrate fluid format.
Galambos, Paul C.; Hopkins, Matthew Morgan; Rahimian, Kamayar; Martin, James Ellis; Anderson, G. Ronald; Clem, Paul Gilbert; Rohwer, Lauren Elizabeth Shea; Lemp, Thomas; Derzon, Mark Steven; James, Conrad D.
Mixed Alcohol Synthesis Catalyst Screening 2007 Progress Report
Pacific Northwest National Laboratory (PNNL) and National Renewable Energy Laboratory (NREL) are researching the feasibility of producing mixed alcohols from biomass-derived synthesis gas (syngas). PNNL is obtaining commercially available mixed alcohol or preparing promising mixed-alcohol catalysts and screening them in a laboratory-scale reactor system. The most promising catalysts are provided to NREL for testing using a slipstream from a pilot-scale biomass gasifier. After a review of the literature in 2006 and conversations with companies that produce catalysts, it was determined that no commercial mixed-alcohol synthesis catalysts were available. One manufacturer supplied a modified methanol catalyst that was tested in the PNNL laboratory-scale system and provided to NREL for further testing. PNNL also prepared and tested the behavior of 10 other catalysts representing the distinct catalyst classes for mixed alcohol syntheses. Based on those results,testing in 2007 focused on the performance of the rhodium-based catalysts. The effects of adding promoters to the rhodium catalysts in addition to the manganese already being used were examined. The iron and rhenium promoters both stood out as achieving higher carbon selectivities , followed by Cu. Iridium and Li, on the other hand, had low carbon selectivity ratios of 0.27 and 0.22, respectively. Although testing of candidate promoters is not complete, it appears that Ir and Li promoters warrant further optimization and possibly combination to further improve STYs and carbon selectivities to C2+ oxygenates. However, using these promoters, it will be necessary to incorporate a separate hydrogenation catalyst to improve the yield of C2+ alcohols with respect to the other oxygenates. Fe, Re, and Cu stand out as possible candidates in this respect, but additional research is needed to examine whether they can be combined with the other promoters on the Rh-based catalyst or need to be optimized on a separate catalyst support that is either physically mixed or used in series with the promoted Rh-based catalyst.
Gerber, Mark A.; White, J. F.; Gray, Michel J.; Stevens, Don J.
Hazard screening application guide. Safety Analysis Report Update Program
The basic purpose of hazard screening is to group precesses, facilities, and proposed modifications according to the magnitude of their hazards so as to determine the need for and extent of follow on safety analysis. A hazard is defined as a material, energy source, or operation that has the potential to cause injury or illness in human beings. The purpose of this document is to give guidance and provide standard methods for performing hazard screening. Hazard screening is applied to new and existing facilities and processes as well as to proposed modifications to existing facilities and processes. The hazard screening process evaluates an identified hazards in terms of the effects on people, both on-site and off-site. The process uses bounding analyses with no credit given for mitigation of an accident with the exception of certain containers meeting DOT specifications. The process is restricted to human safety issues only. Environmental effects are addressed by the environmental program. Interfaces with environmental organizations will be established in order to share information.
ScreenPass: Secure Password Entry on Touchscreen Dongtao Liu
ScreenPass: Secure Password Entry on Touchscreen Devices Dongtao Liu Duke University Durham, NC, USA Eduardo Cuervo Duke University Durham, NC, USA Valentin Pistol Duke University Durham, NC, USA Ryan Scudellari Duke University Durham, NC, USA Landon P. Cox Duke University Durham, NC, USA ABSTRACT
Cox, Landon
Screened Coulomb potentials for astrophysical nuclear fusion reactions
The electron-screening acceleration of laboratory fusion reactions at astrophysical energies is an unsolved problem of great importance to astrophysics. That effect is modeled here by considering the fusion of hydrogen-like atoms whose electron probability density is used in Poisson's equation in order to derive the corresponding screened Coulomb potential energy. That way atomic excitations and deformations of the fusing atoms can be taken into account. Those potentials are then treated semiclassically in order to obtain the screening (accelerating) factor of the reaction. By means of the proposed model the effect of a superstrong magnetic field on laboratory Hydrogen fusion reactions is investigated here for the first time showing that, despite the considerable increase in the cross section of the $% dd$ reaction, the $pp$ reaction is still too slow to justify experimentation. The proposed model is finally applied on the $H^{2}(d,p) H^{3}$ fusion reaction describing satisfactorily the experimental data although some ambiguity remains regarding the molecular nature of the deuteron target. Notably, the present method gives a sufficiently high screening energy for Hydrogen fusion reactions so that the take-away energy of the spectator nucleus can also be taken into account.
antibody screening test: Topics by E-print Network
antibody screening test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 1.9.1 BLOOD GROUPING AND...
A Complete Microfluidic Screening Platform for Rational Protein Crystallization
using the large-scale integration of active microvalves,1 and one using two-phase flows for the mixing developed which uses computer control of integrated microvalves for programmable mixing and screening for the compartmentalization of reactions in an oil/water emulsion, allowing for rapid generation of nanoliter volume "plugs
Hansen, Carl L.
Screening upland cotton for resistance to cotton fleahopper (Heteroptera: Miridae)
Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August 2004 Major Subject: Plant Breeding SCREENING UPLAND COTTON FOR RESISTANCE... TO COTTON FLEAHOPPER (HETEROPTERA: MIRIDAE) A Thesis by DIWAKAR KARTHIK MEKALA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment...
Mekala, Diwakar Karthik
Clinical Cancer Care Full screening services and diagnostics
Clinical Cancer Care · Full screening services and diagnostics · Advanced treatments for all forms of cancer · Most frequent cancers at the Cancer Center: Breast 15% Gastrointestinal 13% Skin 17% Lung 13 treatment protocols that link the latest Cancer Center research to clinical care · Familial Cancer Program
Myers, Lawrence C.
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