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The phytochemical resveratrol has undergone extensive preclinical investigation for its putative cancer chemopreventive properties. Low systemic availability of the parent compound due to rapid and extensive metabolism, may confound its usefulness as a potential agent to prevent malignancies in organs remote from the site of absorption. Micronization allows increased drug absorption, thus increasing availability. Here we describe a pilot study of SRT501, micronized resveratrol, given at 5.0 g daily for 14 days, to patients with colorectal cancer and hepatic metastases scheduled to undergo hepatectomy. The purpose of the study was to assess the safety, pharmacokinetics and pharmacodynamics of the formulation. SRT501 was found to be well tolerated. Mean plasma resveratrol levels following a single dose of SRT501 administration were 1942±1422 ng/mL, exceeding those published for equivalent doses of non-micronized resveratrol by 3.6-fold. Resveratrol was detectable in hepatic tissue following SRT501 administration (up to 2287 ng/g). Cleaved caspase-3, a marker of apoptosis, was significantly increased by 39% in malignant hepatic tissue following SRT501 treatment, compared to tissue from the placebo-treated patients. SRT501 warrants further clinical exploration to assess its potential clinical utility.
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a phytoalexin produced by certain plants when damaged by pathogens such as bacteria or fungi. It occurs in the skin of red grapes and in peanuts, and has been investigated extensively with respect to its putative cancer chemopreventive properties. Resveratrol is thought to mediate, at least in part, the purported disease-preventing actions of red wine and is also considered to prevent cardiovascular disease and morbidity associated with obesity and old age [1-3]. The numerous pharmacological properties of resveratrol and the suggestion that it may be a calorie-restriction mimetic which can prolong life, has engendered considerable interest by the lay press. An abundance of data obtained in cells in vitro and in pre-clinical models has highlighted a plethora of potential mechanisms by which resveratrol may prevent malignancies, predominantly those germane to cell survival and proliferation [4] including p53-dependant apoptosis [5] and cell cycle arrest [6]. However, robust clinical data remain scarce. Recent clinical pilot studies of resveratrol, in which it was administered at single or repeat doses of up to 5.0 g daily, focussed on its safety, pharmacokinetic (PK) properties and the analysis of potential efficacy biomarkers [4, 7-13]. PK profiles of resveratrol in healthy volunteers revealed rapid and extensive metabolism to resveratrol-4′-O-glucuronide, resveratrol-3′-O-glucuronide and resveratrol-3-O-sulfate following oral administration of either a single [8] or repeated daily doses [9] of 0.5 to 5.0 g. Despite detection of relatively high resveratrol concentrations in the colorectal tissue of patients, its systemic availability is severely reduced by its avid metabolism. Consequently, although resveratrol has demonstrated activity against a wide variety of malignancies in vitro (including bowel, breast, bladder, prostate, liver and thyroid) and in vivo (reviewed in [3, 14-16]), it is likely that poor bioavailability may limit efficacy at sites distant to the GI tract. Despite this, there is evidence to suggest that resveratrol elicits chemopreventive and therapeutic effects in pre-clinical models of liver cancer (reviewed in [17]), alluding to potential for efficacy against hepatocarcinogenesis and malignancies that preferentially metastasise to the liver.
Due to the poor aqueous solubility exhibited by resveratrol, digestive absorption is greatly influenced by drug dissolution rate. In an effort to increase absorption across the gastro-intestinal tract and thus systemically available parent compound, there has been considerable interest in the pharmaceutical manipulation of resveratrol. Decreasing the particle size of such chemicals can improve their rate of dissolution and thus their absorption [18]. Therefore, the aim of this clinical study was to investigate whether consumption of SRT501, a micronized resveratrol formulation designed by Sirtris, a GSK Company (Cambridge, MA, USA) is safe and generates measurable and pharmacologically active levels of parent agent in the circulation and in the liver. There is currently no clinical data available that determines resveratrol concentrations in human tissues other than the colon. To this end patients with colorectal cancer earmarked to undergo resection of liver metastases were recruited into a pilot study. They ingested either placebo or SRT501 on 14 consecutive days prior to surgery, and levels of resveratrol were quantified in blood and hepatic resection tissue. Potential pharmacodynamic effects of SRT501 were investigated by comparing the expression/activation of candidate protein biomarkers intrinsically associated with cell survival and apoptosis in the circulation and tissue of patients who received the agent and those who were on placebo.
Microparticular resveratrol of particle size <5 μm (SRT501) was manufactured by Sirtris Pharmaceuticals, a GSK Company. Particle size reduction is believed to enhance the bioavailability of resveratrol primarily due to the increase in surface area and improved suspension properties. A sachet containing SRT501 (5.0 g) was mixed with an aliquot (4 mL) of docusate sodium solution (docusate sodium, citric acid, colorant, glycerin, flavoring, sodium citrate, sodium saccharin and sorbitol) made up to 20 mL in distilled water forming a uniform suspension, and ingested by patients.
The pilot study, designed and sponsored by Sirtris, was conducted at the University Hospitals of Leicester (UHL) NHS-Trust (UHL 10507, trial registry: NCT00920803). It was reviewed and approved by the Leicestershire, Northamptonshire and Rutland Research Ethics Committee (UK) and conducted in accordance with applicable guidelines on Good Clinical Practices. Nine subjects (18 years or older) presenting with confirmed stage IV colorectal cancer and hepatic metastases, who had not received therapeutic intervention for their cancer within 6 weeks of study commencement and had a life expectancy of >3 months, were recruited into the study. All patients were due to undergo resection of liver metastases. Participants had to be physically capable of complying with the protocol and had a normal ECG and no history of HIV or hepatitis B/C.
Patient were asked to refrain from large quantities of resveratrol-containing foods and drinks such as peanuts, grapes, mulberries and alcohol within 48 h of scheduled PK collection days, and the day of surgical resection.
The study was a phase I, randomised (2:1), double-blind clinical trial. Six subjects were randomised to receive SRT501, and three placebo (titanium dioxide). Interventions were provided in clinical kits as a powder and reconstituted as described above. Patients ingested the formulation pre-operatively daily for a minimum of 10 and a maximum of 21 days, dependent upon surgical scheduling. Plasma samples for PK assessment were obtained on days 1 and 2, and on the day of surgical resection. Plasma for PD assessment was obtained pre-dose, immediately prior to, and during surgery. Diseased and normal adjacent hepatic tissue was resected 6-7 h after the last dose. Participants completed a daily adverse event (AE) diary which was assessed using the NCI Common Toxicity Criteria v3. Of the nine patients recruited, seven completed the study, one died from post-operative complications, and one ceased administration early due to AEs (diarrhoea). PK samples were obtained from all nine subjects. The primary objectives of the study were to determine safety and tolerability of SRT501 and resveratrol pharmacokinetics. The secondary objectives were to explore potential pharmacodynamic changes elicited by SRT501 in blood and tissue.
Blood samples were collected prior to administration on day 1, for PK at 0.25, 0.5, 1, 2, 4, 8, 24 h post the first dose, and prior to, and during surgery. Plasma (sodium heparin tubes) and serum were obtained and stored at −80 °C until analysis. Tissues were harvested from resected material, part of which was formalin-fixed and paraffin-embedded, and part immediately frozen and stored at −80 °C until analysis.
Quantitation of resveratrol in plasma and tissues was conducted by Charles River Laboratories, Montreal, Canada. The methodology complied with the US Food and Drug Administration (21CFR part 58) Good Laboratory Practice regulations, using an in-house validated liquid chromatography tandem-mass spectrometry (LC-MS/MS) method. In brief, 50 μL plasma samples were extracted using acidified methanol (ascorbic acid:methanol:formic acid, 50:50:0.025) (5 μL) containing resveratrol-13C6 as an internal standard. Samples were then centrifuged (14000 rpm/0 °C/10 min), and the supernatant aliquoted into a 96-well collection plate for analysis. Separation, quantitation and characterisation of resveratrol was achieved using a Symbiosis Pharma System (XLC method) in conjunction with an MDS Sciex API 3000 mass spectrometer. A Waters YMC ODS-AQ column (3 μm, 4.6 × 50 mm) was linked to a Peek pre-column 0.5 μm filter. The eluant consisted of a binary mobile phase (A; water:formic acid, 100:0.025 (v/v), B; methanol:acetonitrile:formic acid, 20:80:0.025 (v/v/v)). The elution gradient was A85% B15% to A5% B95% for 4 min. Resveratrol was characterised by electrospray mass spectrometry (negative ionisation mode) with ion spray voltage −4500 V, declustering potential −25 V, focusing potential −30 V, entrance potential −12 V, collision energy −27 V, collision exit potential 40 V and temperature 550 °C. Lower limit of quantitation (LLOQ) was 5 ng/mL and upper limit of quantitation (ULOQ) 1000 ng/mL.
Tissue samples were minced on ice and ~100 mg was used for analysis. Acidified methanol (ascorbic acid:methanol:formic acid, 50:50:0.025) (5 μL) containing resveratrol-13C6 as an internal standard, 100 μL matrix green beads and 500 μL ethanol was added to each sample, the mixture vortexed and left on ice (10 min). Samples were homogenised (Fastprep, 2.4-5.5 m/s, 20 sec), left on ice (10 min) and the homogenisation repeated prior to centrifugation (14000 rpm/0 °C/10 min). An aliquot (100 μL) of the supernatant was added to 100 μL water:formic acid (100:0.25). Separation, quantitation and characterisation of resveratrol was achieved using an Agilent 1100 chromatograph with an MDX Sciex API 5000 mass spectrometer. A Waters YMC ODS-AQ column (3 μm, 4.6 × 50 mm) was linked to a Peek pre-column 0.5 μm filter. The eluant was as for the plasma analysis; gradient elution was over 6.5 min from A70% B30% to A0% B100%, then back to A70% B30%. MS conditions were as above except: ion spray voltage −4500 V, declustering potential −120 V, entrance potential −10 V, collision energy −27 V, collision exit potential −10 V and temperature 700 °C. For tissue samples, LLOQ was set at 2.5 ng/g and ULOQ at 500 ng/g. Data collection was performed using Analyst version 1.4.2. (MDX Sciex).
Formalin-fixed tissues were analyzed for markers of proliferation and apoptosis using the NovoLink Polymer Detection System (Novocastra Laboratories, Newcastle-upon-Tyne, UK) in conjunction with anti-Ki-67 (Dako, Cambridgeshire, UK) and anti-cleaved-caspase-3 (Cell Signalling Technology, MA, USA) antibodies. In brief, paraffin-embedded sections were de-waxed at 65 °C and re-hydrated through a series of alcohol washes. Antigen retrieval was via microwaving in either Tris-EDTA (pH 9.0) for Ki-67 or citrate buffer (pH 6.0) for cleaved-caspase-3. Sections were visualized at x40 magnification using a Leica DC300 inverted light microscope and camera system. Images were processed using Adobe Photoshop v7.0.1. Positive staining cells were scored on 10 random fields of view on each slide, and expressed as percent positively stained cells. All analyses were performed blinded.
ELISA assays were undertaken to assess VEGF (Invitrogen, Paisley, UK) levels in serum, PGE2 (Cayman Chemicals, Cambridge UK) levels in plasma and IGF-1 (R&D Systems, Oxford, UK) levels in liver tissue extracts. Assays were performed according to the manufacturers' instructions and ELISA plates analysed using a Fluostar Optima plate reader (BMG Labtech, Aylesbury, UK)
Statistical analyses for pharmacokinetic data included linear regression with 1/concentration weighting and descriptive statistics; arithmetic means and standard deviations, accuracy and precision were calculated using Watson Laboratory Information Management System (LIMS) (version 7.2.0.02) and Microsoft Excel (version 2000/2003).
Statistical analyses for pharmacodynamic data were undertaken using SPSS 16.0 for Windows. Means were compared via one way, one sided ANOVA followed by Tukey's post hoc test. A p value of less than 0.05 was deemed significant.
Nine patients were recruited into the study (for demographics see table 1). Six individuals ingested 5.0 g of SRT501, and three received placebo, daily for approximately 14 days prior to surgery. One patient on SRT501 ceased dosing on day 13. AEs possibly or probably attributable to agent intake are shown in table 2. They were primarily of a gastrointestinal nature, including nausea and diarrhoea, and mild in grade (grade 1 NCI CTC v3.0). Other AEs included chills, lethargy, rash, skin irritation and vascular flushing, which resolved without sequelae, with the exception of one case of lethargy in the placebo group, which was ongoing at follow-up. One patient developed post-operative peritonitis and liver failure, and died during follow-up. The Principle Investigator deemed this serious adverse event (SAE) unrelated to study drug.
Patients' plasma was analysed by HPLC-MS/MS for resveratrol. Resveratrol concentrations were below the lower limits of quantitation (LLOQ) for all samples from subjects receiving placebo, and measurable in patients who received SRT501. Pharmacokinetic parameters for resveratrol are shown in table 3, and plasma concentration versus time curves for individual subjects in figure 1. Cmax levels were reached 2.8 h post-dose, and the mean maximum plasma concentration was 1942 ng/mL (8.51 nmol/mL). The mean plasma elimination half-life was just over 1h.
Resveratrol was quantified in tumor and normal adjacent hepatic tissues. Levels of resveratrol were below the LLOQ in all subjects on placebo and one of the six patients on SRT501. Mean resveratrol levels in the remaining five patients receiving SRT501 were 1098±1393 ng/g (4.81 nmol/g, range 52-2834 ng/g) and 420±341 ng/g (1.84 nmol/g, range 46-914 ng/g) in tumor and normal tissue, respectively.
Potential effects of SRT501 on processes relevant to cell survival and apoptosis were measured in plasma and tissue. There was no difference between patients who received placebo or SRT501 in terms of plasma/serum levels of prostaglandin E2 (PGE-2) and vascular endothelial growth factor (VEGF) (not shown). Tissue samples were analyzed by immunohistochemistry, ELISA or western blot for SRT501-induced changes to levels of IGF-1, Ki67, phospho Akt (ser473), Akt1, phospho-GSK3, GSK3, phospho ERK, ERK, phospho-JNK, JNK, beta-catenin, survivin, BCL2, Bax or PARP. In all cases there were no significant differences between placebo and SRT501 (data not shown). Apoptosis, as reflected by immunohistochemistry for cleaved caspase 3 in tumor tissue, was significantly increased by 39% (to 1.44% total apoptotic cells, p=0.038) in patients on SRT501 compared to those taking placebo (figure 2).
This trial represents the first description of pharmacokinetic parameters for resveratrol after ingestion of SRT501, micronized resveratrol, in subjects with colorectal cancer. The dose of resveratrol employed (5.0 g) is equivalent to one of the dose levels at which non-micronized resveratrol was recently administered to healthy volunteers [9]. In the healthy volunteer study, ten subjects on 5.0 g of the non-micronized resveratrol reported twenty AEs possibly or probably related to ingestion of resveratrol capsules, which compares with seventeen AEs reported for six patients who received SRT501. The two formulations therefore seem to cause a similar incidence of AEs, although in the previous study non-micronized resveratrol was administered for a longer duration (29 days) than SRT501. All AEs reported following SRT501 administration were mild, whilst two of the ten healthy volunteers on non-micronized resveratrol, presented with moderate and one with severe gastrointestinal AEs [9]. This comparison provides the possibility that SRT501 formulated as a suspension may be better tolerated than non-micronized resveratrol given as ten 0.5 g capsules per day. Since micronized resveratrol was expected to afford higher systemic concentrations [19], this finding also suggests that ingestion of a large number of capsules or the presence of non-absorbed resveratrol in the GI tract may be responsible for the adverse effects, rather than the actual plasma concentrations achieved.
The pharmacokinetic analysis revealed that the mean plasma Cmax for resveratrol measured after ingestion of SRT501 (mean 1942 ng/mL , CV:73.3%) was 3.6-fold higher than that achieved following a single dose of non-micronized resveratrol in healthy volunteers (mean 538.8 ng/mL (CV:72.5%) [8], consistent with the superior bioavailability of resveratrol when administered as SRT501 compared to non-micronized agent. The time taken to reach the Cmax for resveratrol was 2.8 h in the case of SRT501 compared to 1.5 h for non-micronized resveratrol [8].
Concentrations of resveratrol achieved in hepatic metastases after administration of SRT501 (0.22-12.4 μM) were of the order of magnitude observed to elicit pharmacological effect in human colorectal cancer cells in vitro and in pre-clinical models in vivo. This interpretation is corroborated by the finding that SRT501 caused a small but significant increase in cleaved caspase-3 immuno-reactivity in tumor tissue, when compared to equivalent tissue from subjects on placebo. Whilst we were not able to confirm these effects via other pharmacodynamic markers, this may be due to low sensitivity of the techniques used. Mechanisms by which low concentrations of resveratrol have been observed to induce apoptotic and anti-proliferative effect in vitro include induction of Fas redistribution and its association with the death-inducing signalling (DISC) complex [20], and via inhibition of wnt signalling and subsequent decrease in nuclear β-catenin localisation [21]. In a pre-clinical model of diethylnitrosamine-initiated hepatocarcinogenesis, significant resveratrol-mediated apoptosis likely resulted from increased Bax expression and consequent increase in the Bax:Bcl2 ratio [22]. Whilst tissue resveratrol levels were not determined in this study, extrapolation of data from rodent PK studies [23, 24] would suggest hepatic resveratrol concentrations necessary for apoptosis induction, to be only moderately higher than the maximum achieved in the SRT501 study described here.
This is the first demonstration that resveratrol can reach potentially active concentrations in human tissues that are distant to the GI tract.
In summary, the results of this pilot study of SRT501 allow three conclusions: i. its daily consumption for 14 days seems to be well tolerated in colorectal cancer patients, ii. Cmax for SRT501 was higher than reported for equivalent dose of non-micronised resveratrol, iii. its ingestion furnished measurable resveratrol levels in a tissue distant to the GI tract (in particular the liver), and these concentrations were accompanied by a significant pharmacological effect.
Micronized resveratrol, as exemplified by SRT501, warrants further clinical exploration in larger cohorts of subjects, in order to test the hypothesis that resveratrol may be of use as a cancer chemopreventive or chemotherapeutic agent.
Grant support: This work was supported by Cancer Research UK on a programme grant [C325/A6691], by Cancer Research UK in conjunction with the UK Department of Health on an Experimental Cancer Medicine Centre grant [C325/A7241] and by Sirtris, A GSK company.
Financial Support: This work was supported by Cancer Research UK on a programme grant [C325/A6691], by Cancer Research UK in conjunction with the UK Department of Health on an Experimental Cancer Medicine Centre grant [C325/A7241] and by Sirtris, A GSK company.
Conflict of interest: This study was sponsored and partially funded by Sirtris, A GSK Company.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.

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After a distinctly disappointing spring, the weather has done an about turn in July, sending us some of the hottest temperatures in nearly a decade.
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After a distinctly disappointing spring, the weather has done an about turn in July, sending us some of the hottest temperatures in nearly a decade.
THE blooming marvellous setting of the Birmingham Botanical Gardens is the venue for a string of plays this summer.
Over a quarter of women (28%) treat themselves to a top-to-toe makeover before hitting the beach on holiday, including manis, pedis, facials and fake tans, according to a survey by QVC.
Like ice lollies and BBQ sausages, some things are just better suited to the peak of summer. It's the same for fashion trends that come with a specific June to September shelf life.
With the season of city escapes and mini beach breaks well and truly upon us, you'd be right to rejoice.
Whichever cosmetics you're taking away with you on holiday, make sure you save space for sunscreen.
While Marc Jacobs led the military charge for spring, elsewhere, designers were clearly in more of a pacifist mood, as the army's favourite shade was thoroughly reworked for Civvy Street.
Wouldn't it be dreamy to have a weekly appointment at the spa for a long, relaxing facial?
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There was a clear winner in the print stakes on the spring/summer catwalks. Stripes were seen everywhere, from Louis Vuitton (rendered in patent leather) and Chanel (long cardis and matching boots) to Paul Smith (natty blazers and drop waist dresses).
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The average wedding now costs a whopping £20,000, according to Time Out magazine. That's a £6,000 rise over the last 10 years - and, furthermore, a survey by Brides magazine revealed the average spend on a wedding dress alone is £1,340.
Over eight decades, Mary Berry has seen food fads come and go. And the latest one - kale - she deals with in typically firm fashion.
The promised 'three-month heatwave' may have sizzled out mere moments after its announcement, but as spring marches on into summer, BBQs are definitely on the horizon (whatever the weather).
From your first spoonful of cereal at breakfast, to that lunchtime sandwich and cupcake teatime treat, much of what we eat every day contains wheat, and with it, the protein that forms gluten.
The RHS Chelsea Flower Show (May 19 to 23) is the greatest gardening show on earth, budding with designers' dreams and botanicals at their best.
If you're in the mood for a cabinet reshuffle, the General Election on May 7 is the perfect excuse to select some top-notch wines, i deal for post-campaign celebrations (or commiserations).
Cosmetics-obsessed vloggers, like Tanya Burr and Zoe Sugg, have taken the world by storm with their step-by-step YouTube make-up tutorials - inspiring us all to get a bit more adventurous with our beauty routines.
Chiming with the change of direction, which saw so many collections veering towards a Seventies vibe, suede overtook leather as the designer hide of choice for spring.
How often do you really think carefully about what you're putting in your mouth?
Now in its second year, Fashion Revolution Day on April 24 marks the day in 2013 when 1,133 people died and more than 2,500 others were injured, when a building housing several garment factories collapsed in Bangladesh.
Argentina is famous for its rich, red malbec, where the grapes can flourish in vineyards planted at high altitude and the sun-kissed fruit comes into its own. Within the last few few years, Argentinian malbec has come to epitomize the delicious damson aromas and soft, velvety flavours that seduce wine lovers fond of an intense, fruity style.
After autumn's Sixties fixation, designers inched forward for spring, landing squarely in the era of bell-bottoms, platforms and feathered hairdos (and that's just the men).
It was the trend story that eclipsed all others in the spring/summer collections. Designers took a hippy trip back in time, their muses the bohemian babes of the Seventies.
The UK splashes out around £365million every year on Easter eggs.
Pulling a dog's tail, sitting on him and kissing his nose are just some of the antagonising ways children act around dogs.
Acne vulgaris, to use its icky full title, now affects 44% of women in the UK, according a survey commissioned by skincare brand Eau Thermale Avene.
Make-up artists at fashion shows have a tendency to get a bit, well, experimental - resulting in catwalk looks that you wouldn't dream of wearing in real life.
There is a lot of talk about devolution to super cities. Actually what we want is devolution to local communities to be given greater powers without bureaucrats getting in the way and top slicing community funds. Super B'ham City council, no thanks! Apparently discussions have already been had between political leaders on the outskirts of Birmingham; funny no mention of this in the recent political campaigning.


text:
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Some cold ass sh*t
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text:
Johnson & Johnson Baby Oil
362 reviews
87% would repurchase
Package Quality: 3.5
Price: $
Package Quality: 3.5
Price: $
INGREDIENTSMineral Oil (Paraffinum Liquidum), Fragrance (Parfum)
on 6/19/2004 5:46:00 PM
Age: 18 & Under
Skin: Combination, Other, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
I bought this product in the hopes it would make my skin super-soft. It took hours to absorb and I hated the smell. Any regular body lotion works way better.
on 6/7/2004 10:04:00 PM
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Black, Straight, Coarse
Eyes: Brown
I use this on the ends of my super-dry, super-frizzy hair and it really makes my hair look healthy! It works better than any de-frizzing serum! Bilosilk Silk Therapy IS a good product, but Baby Oil just seems easier and much less expensive.
on 5/30/2004 5:13:00 PM
Age: 44-55
Skin: Other, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
I love using the J&J Aloe baby oil while still wet out of the shower. I just wish they had an unscented version. Also, I prefer a flip top or maybe a pump?
Nothing works better for super soft skin, especially after shaving too!
on 5/30/2004 4:09:00 PM
Age: 18 & Under
Skin: Combination, Other, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I cannot rave enough about this. I've been using this for over 2 years and it always keeps my skin soft and moisturized-better than any other body lotions I've used. After having a shower when my skin is still damp I apply this and am good to go for 24 hours. I won't ever buy a body lotion again.
on 5/12/2004 5:04:00 PM
Age: 30-35
Skin: Combination, Other, Not Sure
Hair: Black, Other, Other
Eyes: Brown
This may be almost identical to my review of the gel. Love this stuff so much to moisturize after a shower...other oils work initially but I end up dry at the end of the day. Not with this product. Love the fragrance variations too (chammomile, lavendar, though aloe just smells like baby oil.) And it's a multi-purpose item, as it makes a great oily eye makeup remover, bath oil, etc...
on 4/25/2004 2:38:00 PM
Age: 36-43
Skin: Other, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
This is a tried and true product. Baby oil is great for removing makeup, putting on while still damp out of the shower, and for tanning in the sun (no spf in it however). It is just basic mineral oil that is scented. Everyone should keep a bottle of this in their bathroom because it is a great all around product that can be used for so many things.
on 4/15/2004 1:46:00 AM
Age: 19-24
Skin: Sensitive, Fair-Medium, Neutral
Hair: Black, Wavy, Coarse
Eyes: Brown
What can I say that hasn't been already said? This stuff is great, mix half-in-half of water and oil- shake and remove all nasty traces of eye-makeup. Smooth on bod right after a shower and your silky soft all day long! But my fav. thing about baby oil is that scent- so comforting! When I first went with my boy friend he nuzzled his nose right in my neck and said, "God you smell good!" Guys love this stuff. Update: no longer use as I've found J&J do animal testing. Have switched to a natural substitute.
on 4/6/2004 11:33:00 PM
Age: 30-35
Skin: Other, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
Would I buy this again? Yes, because somehow it works well helping keep moisture on my very dry skin after a shower, even though mineral oil does not seem to be something that works for everyone. However, this review is for the regular scented version. The Regular scent turns bad,sharp and musty, especially on a hot day. I can not stand the smell of the regular version on other people. Others may like this, though. All this scent stuff is relative. I prefer the lavender version, but I never detected the lavender on another person to see of it smells good from a sniffer's point of view as opposed to liking the smell as the wearer-a "sniffee" :)
on 3/22/2004 10:52:00 AM
Age: 30-35
Skin: Sensitive, Fair-Medium, Neutral
Hair: Brown, Straight, Fine
Eyes: Green
Uggh.. it's pure mineral oil. Doesn't absorb into the skin. Sits on top and clogs pores. The only reason I'm rating it a 2 is b/c it's so darn good at removing eye make-up. I won't use it though. Not on my face and certainly not on a baby's delicate skin.
on 3/11/2004 1:06:00 PM
Age: 36-43
Skin: Normal, Other, Not Sure
Hair: Blond, Other, Other
Eyes: Green
Now this is a staple that's been around my home for years & years.I can't live w/o this!
I like to sprinkle a few drops of this in my tub when I'm having a relaxing soak.
It's also the only thing I can use to remove wax product when I do my at home waxing. :_O
Handy for a plethora of beauty essentials,this is a product that will be around for years to come.
Love it!!! :_)
Popular Body Skincare Products


text:
Available in the Library
NOTE: As of May 13, 2013, we require two forms of ID for device/equipment check outs (laptops, iPads, eReaders, etc.). A valid FIU One Card and government-issued ID must be presented.
Devices circulate for 4 hours with an overdue fine of $30.00 per hour--except where noted.
|Technology Available for Loan
|Tablets (24 Hour Loan)
|Computer Accessories and Components
|E-Readers (14 Day Loan)
|Miscellaneous Devices
iPad and Tablet FAQ


text:
Click on a thumbnail to go to Google Books.
Blood Oath (edition 2010)
by Christopher Farnsworth
Work details
Blood Oath by Christopher Farnsworth
No current Talk conversations about this book.
An interesting take on the vampire... not bad. I will check out the others in this series.
Blood Oath delivers exactly what it promises - a unique, genre-bending mix between horror, political thriller, and action novel. Extremely fun and entertaining.
Blood Oath is a cross between a political thriller and a vampire novel. A vampire who has served American Presidents since Andrew Johnson is caught up in a conspiracy at the highest levels of government involving the original Dr. Frankenstein, a shadowy off-shoot of the CIA, Middle Eastern terrorists, and most likely the Vice President as well.
Overall, it is pretty formulaic. But it delivers well on the formula with short, effective chapters that read like a screenplay. It ends with a global montage that dangles several loose ends for sequel(s) -- but as much as I enjoyed this one, I don't think I'll be reading the next because it won't have the most interesting parts of this which were the backstory, the creation of a believable vampire world, etc But I'm glad I read this one.
Thought I would try this because I rather like a good Vampire story as long as it's not too vapid and well, nobody...sparkles. I also am a fan of Robert Ludlum's books, and this rather reminded me of them in some spots with the action sequences.
My favorite approach to the Vampire mythos--well any fantasy/science fiction really--is when an author has a very logical world set up, definite rules for how the Vampire or fantastic creature must live and act, and a good back story for how they got that way. I have a medical background so I guess that's why I like to have things explained to me logically--almost like I'd be making a diagnosis. I really enjoyed the "reports" and "data" that was offered in each chapter regarding the "subject", Nathaniel Cain. I do wish we got to know him better, but that only made me want the next book more to be honest. I guess that's part of the old maxim of always leave'em wanting more.
The story of the President binding the Vampire to him through Voodoo was very affecting once they got to the point where Nathaniel tells it. I've always been an X-files fan so, why not have a Vampire who works for the President seeking out that sort of thing? A very good use for one if you can find one. The relationships between the FBI handler and Cain was really handled well. Actually the characters were all very realistic. I enjoyed the smart alec, politically savvy young whipper snapper who is suddenly saddled with being Cain's handler. He was a wonderful contrast to the previous handler.
And I just started to type spoilers so I'll wrap it up. This is a really well written book that I enjoyed greatly. Then, I read it out loud to my daughter and she also enjoyed it. (She's 9 so there was some mild censorship as I read. lol) She also enjoyed the action and the drama. Thank goodness she wasn't as aware as I was of how close to the headlines the book felt at times with our history of terrorist attacks--which made the threat in the book seem only more real.
Highly recommended.
Got this at the local Dollar Tree store. Was surprised at how well I liked it. Like some reviewers have said it does read like it's a screenplay for a movie. Is kind of FBI Agent/James Bondish in some areas but a fun read all in all. Has a vampire that is tied to the president. Story reads as if it may be the first in the series. Some people have noted that the lead character, Cade the vampire, is kind of shallowly written. This is our first foray into his world and we get some backstory. But will hopefully get more character backstory if it does run into a series.
References to this work on external resources.
Wikipedia in English (1)
Amazon.com Product Description (ISBN 0399156356, Hardcover)
Zach Barrows is an ambitious young White House staffer whose career takes an unexpected turn when he's partnered with Nathaniel Cade, a secret agent sworn to protect the President. But Cade is no ordinary civil servant. Bound by a special blood oath, he is a vampire. Cade battles nightmares before they can break into the daylight world of the American dream, enemies far stranger-and far more dangerous-than civilians have ever imagined.
Watch a video
Blood Oath is the first in a series of novels featuring Nathaniel Cade-the President's vampire.
"Christopher Farnsworth's taut thriller Blood Oath is an irresistible page-turner.... A complex and unnervingly realistic tale in which vampire Nathaniel Cade is far less of a monster than his human colleagues at the CIA and FBI. Dazzlingly clever."—The Washington Post
"Blood Oath is exactly how I like my Presidential thrillers. With vampires."—Brad Meltzer, author of The Book of Fate
"Blood Oath is the vampire novel that finally gets it right. Christopher Farnsworth has done his homework in places where most writers wouldn't even know to look-and the result is a rollicking tale of the supernatural grounded in some of the true oddities of American history. If Dan Brown wrote a vampire thriller, this would be it."—Mitch Horowitz, author of Occult America
"As someone who thinks Stoker's Dracula has never been bettered, and who would happily stick a stake through the heart of most modern vampire fiction, it almost pains me to say how much I enjoyed Blood Oath. Witty, exciting, and compulsively readable, with a central character who seems destined to become a favorite of both skeptics and true blood believers, this may just be the best debut vampire novel in many years." —John Connolly, author of The Lovers
Zach Barrows is an ambitious young White House staffer whose career takes an unexpected turn when he's partnered with Nathaniel Cade, a secret agent sworn to protect the President. But Cade is no ordinary civil servant--he is a vampire.
(summary from another edition)
Amazon Kindle (2 editions)
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text:
ABX Express (perak) Sdn Bhd Jawatan Kosong Operations Supervisor Jun 2015
Operations Supervisor ABX Express (perak) Sdn Bhd
ABX Express (perak) Sdn Bhd provide terms, conditions and specifications of the Job as Operations Supervisor which will be placed in Kinta
Below are the complete of requirements, job specifications, schedule of interviews and addresses and contact (email or phone number) of The Company.
Company : ABX Express (perak) Sdn Bhd
Location : Kinta
City : Kinta
State : M08
Country : MY
Published at : Fri, 24 Apr 2015 05:34:45 GMT
Job Description
Basic salary of RM 1,300.00 + Overtime + Incentives
• Annual Leave
• EPF and Socso
• Keeping records of well experienced and well take care of the lorry.
• Able to work overtime.
• Disciplined, honest and timely.
• Have a clean record
• No records have CTOS and Saman Traffic & RTD
• MUST have experience in Operation Morier
• MUST have a vehicle Driving Licence Class B2, D and GDL
• MUST have a clean driving record
• Men (aged 22-35 years)
Lowest Qualification: SPM / O Level
Closing Date: 2015-06-24
If You interested and meet the requirements please submit your application immedietly :
To submit your application by online, click on the link labeled with Apply Click Here or Apply This Job at the bottom of this Job vacancy information. Hopefully you get your dream Job….!
Notes :
- Kindly note that applying to this job also means that your application will be forwarded to employers with similar job vacancies available.
- If you do not wish for your resume to be forwarded to other employers, please do not apply to this job vacancy.
- Only shortlisted candidates will be notified
More Jobs Available :
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text:
Quinto On Spock And Sylar
View Single Post
October 3 2008, 08:34 PM
Temis the Vorta
Fleet Admiral
Location: Tatoinne
Re: Quinto On Spock And Sylar
Spock's behavior in WNMHGB (or was it The Cage?) was so different than later Spock that it's easy to assume he just matured some in-between. Less shouty*, more confident, not trying so hard. That gives Quinto plenty of space to make the role his own without upsetting the canonistas (any more than they will insist on being upset).
*Not that I want QUINTO'S SPOCK TO BE CONSTANTLY SHOUTING!!!!
Moving on to Sylar...
Quinto feels that there is a chance to redeem Sylar, that he isn't all bad. "It depends on what his motivation is," said Quinto. "He has a lot of different reasons to do things this year. They don't all originate from himself. He's being put into situations where he has to do stuff for other people."
A lot of
fans want Sylar to diediediediedie, but I never figured that would happen before
Trek XI
comes out. Kring will want to use the publicity to help
(the way the Nielsens are going, they can't get cocky). Sylar's survival hinges on the success of
Trek XI
- if there are going to be more movies, Sylar is far more likely to live.
And for him not to be repetitive, he does need to be "redeemed" in some manner, though what that means and how it is plausibly accomplished remains an open question. The writing on the character has always been iffy; Quinto is really holding up far more than the actor's usual half in making a character work.
Temis the Vorta
View Public Profile
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text:
Maury Povich, left, speaks with Wayne County Circuit Judge Wade McCree on the set of syndicated talk show ?Maury? in New York.
- Filed Under
Updated at 5:37 p.m.
If you're a deadbeat dad who agrees to start making child support payments to stay out of jail, you've got to meet one more requirement in Judge Wade McCree's Detroit courtroom: Watch the Maury Povich show.
McCree, a criminal judge in Wayne County Circuit Court, has begun sentencing dads to watch the show as part of their probation. The judge, who will appear on the show Thursday, said he got the idea after watching a few episodes. One day in February he shouted to a man with five kids from five mothers: "What the hell do you think this is, the Maury Povich show?" ...


text:
Home Tutor - Microsoft Windows 8 Edition
Learn how to quickly master Microsoft Windows 8 with this series of 192 Tuitional and informative video lessons.Lessons includeMicrosoft...
Learn how to quickly master Microsoft Windows 8 with this series of 192 Tuitional and informative video lessons.Lessons includeMicrosoft...
Microsoft's rather complicated Windows 10 as a service strategy is slowly coming into focus.
Microsoft now has more than one million testers trying out Office 2016 for Windows and Mac, officials said, and they'll be getting more new features to test drive 'in the coming weeks.'
Microsoft has yet to detail which versions of Windows 10 get which features. But there is a bit of new information about what Windows 10 Enterprise users can expect later this year.
It's not a release candidate, but the latest Windows 10 preview has plenty of interesting new features and apps to explore. Here are some first impressions on what's improved and what's still missing in action.
Microsoft is continuing to roll out monthly updates for its Intune device-management service. Here's what's in the batch for May.
IMPORTANT NOTE: The newest version of this app is Air Display 3. We are leaving this version in the App Store for backward compatibility....
Microsoft is slowly but surely trying to wean IT pro to make changes in the way they validate and apply new fixes and features in preparation for Windows 10 and Windows Server 2016.
Microsoft is promising to add, after RTM, a number of new features -- and to cut some legacy ones -- with its Windows 10 Edge browser.
iWindowsProg is the most powerful Windows, Database, Visual Studio & TFS client application for iOS devices. For detailed information...
Arduino developers can now take advantage of cheap sensors and processing capabilities in Windows 10 devices to add new features to projects.
The first fruits of Google's Lucid Sleep effort for Chrome OS arrive on the Chromebook Pixel, bringing an always-on Wi-Fi connection in a low-power state.
Microsoft has made available another new test build of Windows 10 Desktop that includes a number of new features and updates, including new mail and calendar apps.
The latest build of the Windows 10 Technical Preview for phones made it into the hands of beta testers over the weekend. Although it boasts a few interesting new features, some very rough edges and key missing pieces make this release for diehard testers only
Windows 8 was filled with bold ideas, designed to move Windows forward in one giant leap. Three years later, as Windows 10 nears its release date, many of those innovative ideas are gone. Here's a look at what's been tossed away, and why.
Microsoft highlighted the features in Windows 10 and outlined how it plans to connect the economic, developer and customer dots. Will it work?
What's next for Windows 10? This week's unveiling in Redmond should focus on consumer features. It will also reveal how well Microsoft is coping with the unprecedented shift from traditional PCs to mobile computing. Here's what I'll be looking for.
One of Jide's founders says Android tablets are "terrible" for doing work, so the company created a productivity-based tablet with 11.6-inch screen, detachable keyboard cover, and the Remix OS, which adds Windows-like features to Android.
With software-defined storage in Windows Server, you can get SAN features without paying SAN prices -- and the next release will challenge more high-end storage features.
Microsoft's MDOP 2014 R2 set of management and deployment tools for Windows, adds new application and user-experience virtualization features.
From secure containers to Docker support, to abstracted networking and storage, the most interesting features in the next version of Windows Server will come next year with a later preview and System Center beta.
Microsoft officials are revealing a few more of the Windows 10 features testers should expect in the coming months.
Windows 10 will build in standards-based two-factor authentication to every device, effectively neutering most phishing attacks and password database breaches. The company also announced new features aimed at securing corporate machines from malware attacks and data leaks.
Windows 10
How much does an iPhone 6 really cost? (Hint: It's way more than $199)
How to survive an iPhone liquid submersion (hint: it's not rice)
Microsoft's new mission statement: No more computer on every desk


text:
Mercedes-Benz SL600 Problem Report
Mercedes-Benz SL600 Oil Leaking From Oil Level Sensor
(11 reports)
An engine oil leak may develop from the oil level sensor. Replacement of the leaking sensor will commonly correct this concern.
Related Items:
oil pump support in the way .
Where is the fuel level sensor on this car? How do I access it?
might there be a seal that has leaked
The active body control system can leak fluid from numerous areas, including the tandem pump, h...
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/...


text:
to explore
sign up (free!)
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cardinal in snow, love seeing them outside my window! They are so beautiful, just like all God's creation!
Cute male cardinal watching the snow fall... this cute little red bird against the white snow is such a cozy winter scene!
"Winter Cardinals on Goldenrod" by Larry Zach I think this would make a pretty Christmas card
Northern Cardinal...wish we had these in Utah, but have seen them in the South, Charleston and Jekyll Island.


text:
Woman who stabbed U.S. teacher in UAE was "lone terrorist"
Police arrested the UAE national last weekDecember 8, 2014 10:55
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She is very good at keeping me informed of the process and very prompt retuning phone calls. Laura has been great about working with my schedule to get everything done. I would highly recommend her for your next home purchase.
Laura Albrecht
2 Recent Sales (last 12 months)
Real Estate Professional (12 years experience)
- Specialties:
- Buyer's Agent,
- Listing Agent,
- Consulting,
- Appraisal
Ratings & Reviews
Laura was so helpful in helping us find our home, we really thought she did an awesome job, an have sent many family and friends to her. We love our home and are very happy with our experience dealing with Laura, she is a great honest lady.
A very talented lady that really knows what she is doing in real estate matters. She is very honest and has lots of integrity.
I very highly recommend her for your real estate matters.
She sold two pieces of property for us.
Robert McCabe
Working with Laura has been wonderful. She has been very knowledgeable and just all around wonderful in helping us with selling our property. We had interviewed other agents that were not as knowledgeable as Laura or as willing to help. The property is rural which requires more travel and more knowledge of the area. Before our first phone conversation she had researched the area and was prepared with specific facts and a plan. We are in the listing process now and she has been very helpful in making sure the property is as inviting to prospective buyers as possible. She has been prompt with return emails and phone calls. Always courteous and professional when we have communicated. I would recommend her services to anyone looking to sell/buy or both.
I interviewed about 6 local agents in Vidor and was most impressed by Laura's enthuiasm, her flexibility and inventative approach to marketing, and her willingness to take on a difficult listing. The property was sold in a satisfactory manner.


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VIEWS: 23 PAGES: 7 CATEGORY: Business POSTED ON: 11/15/2010 Public Domain
Original Birth Certificate Pennsylvania document sample
UCP Central PA 2005-2006 Board of Directors Marion C. Alexander Janak Amin Joanne Book, Esquire Frank Clark, Esquire Sandra Drummond Ben Francavilla Todd Getgen, Esquire John Hickey, Esquire Karen Horan Dwayne Keller Gerard C. Kramer, Esquire UCP Central PA- Gregg Mace Richard Michaelian Christopher Rockey Schmidt, Ronca, & Kramer, PC Karen Roland Jackie Singel George T. Sweeney Tonia Leitzel Ulsh Paul Wagner David Weakland William Wilkison 2005-2006 Life Board Members Lawrence B. Abrams III, Esquire Attitude Essay Contest Doris Brunner George E. Ferrey, Jr. Glenn Hoffman William J. Kaldes Shaun O'Toole, Esquire Susannah J. Rothman Todd Vander Woude For more information contact: Shawn Kaup Community Relations Coordinator email@example.com or 717-975-0611 x 233 UCP Central PA The mission of United Cerebral Palsy of Central Pennsylvania, Inc. (UCP) is to assist infants, children, youth, and adults, with disabilities, and their families, achieve their goals of development, growth, independence, and full citizenship. We encourage and strengthen skills and capabilities for each individual so they may become as independent as possible. UCP is one of the most comprehensive agencies in the United Cerebral Palsy network. For more than 52 years, we have been a leader in assisting people with disabilities. UCP provides services and programs for more than 2100 children and adults, with disabilities, and their families. Services are provided in 11 Central Pennsylvania counties. UCP operates from 15 facilities: the Capital Area Children's Center, eleven adult day programs, and three group residences. At UCP Central PA, more than 92 cents of every dollar raised goes directly to programs and services. Who We Serve UCP Central PA UCP Central PA provides services to diverse groups 925 Linda Lane of people – not just those with cerebral palsy. Over Camp Hill, PA 17011 94% of our program participants have developmental (717) 737-3477 and acquired disabilities other than cerebral palsy. or Toll Free: UCP Services are needed now more than ever due to 1-800-998-4UCP the increased number of children diagnosed with autism, and premature and low birth weight babies, www.ucpcentralpa.org who have a greater probability of developmental disabilities. History of the Contest Just before Christmas, 1993, a young girl in Ft. Wayne, Indiana wrote a letter to Santa Claus asking for one day at school during which the other children would not make fun of her because of her disability. Amy Hagadorn has cerebral palsy, walks with a limp and sometimes uses a wheelchair. The local newspaper published her letter, the national media picked up on the story, and letters from every corner of the world began pouring into the Hagadorn household. Ft. Wayne even had an "Amy Hagadorn" day, complete with a parade and Amy riding on a float. Two years later, the "ATTITUDES" Essay Contest was initiated through the joint efforts of United Cerebral Palsy Association of Greater Indiana and the Indiana Governor's Planning Council for People's with Disabilities. In March 1996, 38 children in Marion County responded to an invitation to participate in the contest; four children were awarded cash prizes; all essayists received "ATTITUDES" buttons and certificates of participation. Including the 1999 contest, more than 1300 essays have been submitted from 81 schools throughout Indiana, thanks to the encouragement of 143 teachers of grades 3 through 8. Three first place and second place winners have been honored each year at a luncheon and the essays of more than 100 children have been published in four booklets. In 1998, Amy's story was included in the Chicken Soup for Kid's Souls book. The "ATTITUDES" essays were hand-written and typed on computers; some included computer art or hand-written illustrations. Some children with disabilities wrote of their own experiences; typically developing children interviewed people with disabilities; others wrote of their observations; still others wrote fictional accounts or poetry. The children wrote about disabled veterans, grandmothers with Alzheimer's, celebrities with spinal cord injury and polio, and local heroes with cerebral palsy. They wrote about school friends with mental retardation, diabetes, learning disabilities; and they wrote about relatives with hearing or visual disabilities and those with multiple sclerosis or arthritis. The essays included expressions of pity and awe; many children admonished non-disabled adults not to be inconsiderate nor too helpful to people with disabilities. Each essay illustrated amazing wisdom and the basic kindness of each author. Each writer clearly thought about the challenges experienced every day by people with disabilities and about the barriers created by people with "bad attitudes" (those with and without disabilities). Some essays created new ways of thinking or talking about people with disabilities; some criticized the stereotypes that have historically limited people with disabilities. Many essayists were knowledgeable about laws relating to education, employment and access for people with disabilities. The authors, we hope, represent a generation of Americans who will understand and value the ABILITIES of all people. They recognize that a disability becomes a handicap only when structural or attitudinal barriers made it so…and they're determined to help break down those attitudinal barriers. Attitudes Essay Contest Get an Attitude! Since 1999, UCP Central PA's annual essay contest for school students from grades 3 through 12 encourages young people to write about persons with a disability that they have met, read about, or saw in a movie, and how their opinion of persons with a disability has changed for the better. Each year, hundreds of young people participate from school districts throughout Central PA. Essays are anonymously judged by teachers and other parents, with cash awards, buttons and certificates of appreciation given as top awards in three categories. How to get started 1. Call UCP's Community Relations Department at 717-975-0611. 2. Distribute participation packs to students. 3. Generate excitement 4. Collect essays and mail them to UCP. 5. Plan an assembly to congratulate the winners! It's that easy!! Program Facts The program runs September through April. There are four age groups 3rd & 4th grade, 5th &6th grade, 7th & 8th grade, and 9th through 12th grade. More than 350 packets are mailed to schools in Central PA. Average participation is 400 students. In five years, more than 2,400 essays have been submitted. All participants receive a button and a certificate of participation. More than $1,000 in awards are given to 1st, 2nd, and 3rd place winners in each category. Contest Rules & Guidelines WHO MAY ENTER Any Central Pennsylvania school student in grades 3 through 12 may enter the contest. DIVISIONS (A) Grades 3 and 4 (B) Grades 5 and 6 (C) Grades 7 and 8 (D) Grades 9 through 12 CONTEST RULES: 1. Each student may submit only one entry. 2. All entries should be typed or legibly printed on 8-1/2 by 11 white paper. 3. Entries should not exceed 500 words (count every word except the title). 4. Entries must include a completed entry form, (copies are acceptable). 5. All work must be original. (Parents, it's ok to check for spelling and grammar but not content!) 6. Entries must be submitted to UCP Central PA no later than January 31, 2006. 7. No entries will be returned, so be sure to keep a copy for yourself. ESSAY CONTEST 1. Interview a child or adult with a disability and describe his/her experiences with the attitudes of others, OR 2. Read a book about people with disabilities and describe the impact of attitude on their lives, OR 3. Write about your own observations or feelings about attitudes toward people with disabilities. JUDGING PROCESS 1. All essays will be judged on the basis of creativity, originality, quality of writing, and understanding of the issue. 2. A panel of professional judges will select the winners in each division. 3. Winners will be announced and prizes handed out at your school's year-end awards assembly in the spring. Mail essays with entry form attached to: Attitudes Essay Contest c/o UCP Central PA 44 S. 38th Street Camp Hill, PA 17011 Person First Language Examples to use and share Labels not to use… People First Language… the handicapped or the disabled people with disabilities the mentally retarded or he's retarded people with mental retardation or he has a cognitive impairment my son is autistic my son has autism she's a Down's; she's a Mongoloid she has Down Syndrome birth defect has a congenital disability epileptic a person with epilepsy wheelchair bound or confined to a uses a wheelchair or a mobility wheelchair chair or is a wheelchair user she is developmentally delayed she has a developmental disability he's a crippled; lame he has an orthopedic disability she's a dwarf (or midget) she has short stature mute is nonverbal is learning disabled or LD has a learning disability afflicted with, suffers from, victim of person who has… she's emotionally disturbed; she's she has an emotional disability crazy normal and/or healthy a person without a disability quadriplegic, paraplegic, etc. he has quadriplegia, paraplegia, etc. she's in Special Ed. she receives Special Ed services handicapped parking accessible parking Attitudes Essay Contest Entry Form 2005-2006 CONTEST DIVISION (check one): Grades 3-4 Grades 5-6 Grades 7-8 Grades 9 - 12 NAME: _____________________________________________________________________ ADDRESS: __________________________________________________________________ CITY: ____________________________________________ ZIP CODE: _______________ TELEPHONE: (___) _________________ EMAIL: _________________________________ I certify that this is my original work (signature): ___________________________________ SCHOOL: ___________________________________________________________________ TEACHER: __________________________________________________________________ SIGNATURE OF PARENT OR TEACHER: _______________________________________ (THIS SIGNATURE INDICATES THAT THE SIGNEE HAS READ THE ENTRY AND VERIFIES THAT IT IS AN ORIGINAL WORK THAT HAS NOT BEEN PLAGIARIZED.) Mail to: ATTITUDE Essay contest c/o UCP Central PA 44 S. 38th Street Camp Hill, PA 17011 Essays must be submitted to UCP Central PA no later than January 31, 2006 If you have any questions regarding the contest please contact Shawn Kaup, Community Relations Coordinator at firstname.lastname@example.com or 717-975-0611.
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Morgan Freeman falls asleep during interview Add to ...
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Holly Clegg: Gulf Coast Recipes
Holly demonstrates fabulous and calorie-reduced holiday meals.
Holly demonstrates fabulous and calorie-reduced holiday meals.
Food Network chef Ellie Krieger has a unique food plan to eat well and healthy in the new year.
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EI-LO offers designers, manufacturers, and apparel brands the perfect T-shirt at the perfect price point. We combine quality blank knit apparel with easy ordering, no minimums and immediate delivery. As a completely vertical manufacturer, we control every aspect of the process to ensure the highest quality products. Using 100% USA Cotton & Ring-spun Yarn our fabrics are softer, more stable and are USDA and NAFTA Certified. For more info please visit
There is no better publication that I am aware of that is so accurate and on top of any news and developments in our industry. I personally recommend it to many people that want to know and understand more about our industry. For the most part, shop-eat-surf.com gets the stories first. As a matter of fact, I require all the executives in our company to read it.- By Hezy Shaked, President & CEO, Tilly's
I'm an avid reader of Shop-Eat-Surf because it's really the only online newsletter that I have found that is not only industry related, but also because it's not so "guy-centric." I find that a lot of the information I read on the site pertains to my business (as a swimwear designer) and keeps me up to date on what other companies and other women in the industry in general are doing which is not only inspiring but also helps me gauge the future direction of my business as well.
I feel privileged to read the Executive Edition because I know I am getting insider industry information before it hits the mainstream media channels. And it's always good to know what my friends are up to in the industry.- By Monica Wise, Founder, L*Space
AGENDA: Last chance to register before July 8-9 show.
ISPO: Shanghai trade show runs July 2 - 4.
Details on Industry Insight.
Press Release:
Hurley has announced that they will partner with iconic artist C.R. Stecyk III to debut his new short film FIN on February 8th at Hurley's H Space Gallery in Costa Mesa, CA. Taking inspiration from the film, Hurley is also creating a limited-edition printables collection featuring art and photography captured during the film's creation.
"Stecyk is both a celebrated chronicler of the art, surf and skate cultures as well as a longtime friend to the Hurley brand. When he told us of his plans for the film, we couldn't pass up the opportunity to work together to bring his vision to life," states Jason Maloney, Hurley's Director of Art.
FIN, the first installment in an evolutionary series of digital film shorts, details Stecyk's method of working with a wide variety of personages in the southern California region and reflects the social and sonic landscapes in which these creators inhabit.
People whose work has been documented so far include Von Dutch, Ed "Big Daddy" Roth, Evel Knievel, Dave Sweet, Julian Ness, Tom Blake, Dale Velzy, Tyler Hatzikian, Scott Anderson, Mitch Abshere, Scotty Stopnick, Mike Ness, and Roland Sands.
The featured soundtrack is also a nod to West Coast visionaries, with Social Distortion, Breakdown, Tommy Guerrero and Steve Alba and the Powerflex 5 contributing to the project.
"FIN investigates artisan garage culture. It will offer insights into an assortment of individuals who incorporate traditional do-it-yourself garage methodology into differing pursuits such as traditional modified vehicles, surfboards, skateboards, art, music and communications," states Stecyk.
The subsequent printables collection will feature a series of 4 t-shirts showcasing exclusive artwork and still photography captured during the making of FIN. The printables collection will be available for purchase on Hurley.com in conjunction with the film's Costa Mesa debut on February 8th. The film will then travel to Hurley's additional H Space galleries in Bali and Tokyo for international premieres.
The trailer for FIN can be viewed here.
C.R. Stecyk III is an artist/curator who has participated in over three hundred international art exhibitions. As a longtime chronicler of the California scene he has written for a variety of publications and authored a number of books, and catalogues dealing with contemporary culture. Stecyk was also the production designer and co-writer of the documentary film Dogtown and Z Boys which won major awards at Sundance and other festivals.
"Hurley is a company based on inclusion," says chairman and founder Bob Hurley. This philosophy applied to Bob Hurley's early years as a Huntington Beach shaper, working with friends alongside the world's best athletes to make a better surfboard. It applied to the company's launch in 1999, when Hurley decided to start a brand that was a true microphone for youth. In 2002, Hurley was acquired by Nike - the largest and most influential sporting brand in the world.
Inclusion remains a guiding principle of the company today, where innovative products like Phantom Boardshorts and game-changing events like the US Open of Surfing continue to redefine what is possible in our world. Hurley headquarters are in Costa Mesa, CA with international offices in Sydney, Tokyo, Barcelona and Bali. www.hurley.com


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SOUND HOUSEKEEPING: Poole Civic Centre
Diana Henderson / / News
NO council tax increase is being recommended this year by Poole's cabinet.
The recommendation, which will go to full council on February 25, is to not raise council tax for 2014/15.
If the full meeting of Borough of Poole accepts the proposal it will mean that council tax has not gone up since 2010.
The annual charge for council services on a Band D property in the town would remain at £1,209.60.
"Over the past four years the council has worked hard to absorb £43.5mi-llion of budget pressures and cuts in government funding while minimising the impact on frontline services," said council leader, Cllr Elaine Atkinson.
"Despite this challenge, I am pleased to say that we are again in a position to deliver a balanced budget and to recommend no increase in council tax for a fourth successive year.
"This has been achieved through careful financial planning, effective management of our resources and use of our limited reserves," she said.
However the medium term financial plan estimates the council must save a further £34.5m by 2018, the equivalent of 23 per cent of its budget for 2013/14. A cross-party budget steering group, including councillors from the borough's three political groups has been established to consider options for further savings and efficiencies.
Cllr Atkinson said: "There is no doubt that the council faces an enormous financial challenge in the future and difficult decisions will need to be made over the next few years.
"While good progress has been made to identify areas where we can make further savings, there is still a lot of work to be done."
While the council's element of council tax will not change, residents will face a 1.96 per cent increase in the Dorset Police precept and Dorset Fire and Rescue Service was due to meet yesterday.
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Poole council cabinet recommending no council tax increase this year
Wise considering that interest rates will soon be on the rise in the UK.Wise considering that interest rates will soon be on the rise in the UK. Chris@Bmouth Wise considering that interest rates will soon be on the rise in the UK.
Yep real pleasure to live in Poole, roads looked after ,swept and drains unblocked,and weeded . Great shopping and parking facility's ,great night life and entertainment , and a real sense of security from our police force that we can sleep soundly in our beds ,knowing that our welfare and premises are being guarded and looked after !
They having a laugh yes !!!!!
They having a laugh yes !!!!!


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Oregon Ducks
After beating BYU, UVa looks ahead to Oregon
Machine Generated Transcript
CSN Washington dot com. I think -- it was it was a great victory for the entire team for the players and coaches. And I think by the resiliency that the players had me it was a a two hour ten minute delay. You know -- and we could've folded but that that's a very good BYU team that's experienced. On their defense was number one number two in the country last year and we've put enough points on the board at the end to win and so it was a it was a good victory for the program. Now my -- that I -- a loss of voice their you know but right after the started the third quarter but. You know it's it was an emotional game and in terms of just the ebb and flow and went back and forth and you know every play you know was a big play -- actually. The last you know last few six plays of the game kind of determined you know the direction. And it was just exciting to watch. All are still fairly young team you know mature a little bit. And and gain victory over very experienced team -- you know Anthony's is an experienced player forces starter last year and secondary and and being able to make you know big plays not only on defense put obviously special teams. You know Anthony's -- one of our team leaders and he's a great young man great represented this university. You know one of the things -- does is he can he can they -- free safety which was completed people but also he can. PC is down in the box you know that eighth defender when you when you have bring you see that he can make plays that way so. We're gonna have to change roles you know got to go back and forth will we have asked him to do would definitely you'll have to be one of those guys in the box. Because they got great players you know obviously -- one of the best better players in the country. But the quarterback very -- he's fantastic as well they got a throwing game the the matches the office of the running game so. We're gonna have to make sure we try to put it to be in that position to help us. You know that pin on how they're going to attack us a lot and it is gonna have to have another good game. On me the reality of it is with the social media TV and in print things like that everyone knows about this or his team everyone knows about the uniforms everyone knows about. New facilities that they have I mean you know their national brand has been marketed by by Nike. You know our our our charges to you know eight they put their pants on the same way we do. We have to execute our game plan as as I know they are the two competent doing. But it's about us more than anything else and have another. High high volume you know high temple office. Like BYU did you know we put a lot of points as you said. One of the they had the best turnover margin you're in the country because they scored also get the ball back you know defense. So our work is cut out forces do we need to do we need to be simpler game plan our hats and our gap rally to the football and we'll have to make a lot of open field tackles you know they spreads you out it. You know again we respect all opponents you don't hear them but we respect them. We know they have talented players split you know it's it's it's not a home game for us. National spotlight game -- any chance to show we can do. -- you know it's hard to simulate that I think. One of the things we we found out just threw you gather information at the you know last this past Saturday BYU averaged about sixteen point seven seconds per play. And you threw through information -- -- organ. Ran a play against the team they played. Which averaged about sixteen points and so the paste if not faster will be asked fast and being able to get acclimated to that is going to be critical be key for us. Get lined up and get the right calls this it before had the gap. I'll make sure the coverages are or sound. And and the rally to the football and that's that's the best you can do it in the -- -- get a break here and there you know we play hard. We play fast as well and and I just know that that each of us are gonna have to rely on each other because again you're going it's a team it. Is it is is highly touted. In you know -- and number two number three you know excellent football team. What they're playing -- and Charles who Virginia's -- Well you know when you look at and -- -- talk about Chip Kelly leaving and going to the Eagles and what was or is going to be looks to me they had missed a beat I mean obviously Scott for losses is called the other plays out who's helped ridges. Is still running the same system and the players -- used to the system and temple. In this scheme. They execute well and it is no secret why the last four years of average almost 45 points. A game and you know why -- -- such a high -- -- office so they do play well they they they play well as a team. There's a system and culture that they have and and that's why there's good as they are so. Again you know we can't get into all the things that they are we just have to worry about what Virginia is what we have to do and and then able to play good game on Saturday. CSN Washington dot com.
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Morris who won this Dallas. I've seen him who's left on the other. Do you celebrate. It it's actually pleasant enough. Oregon need to be in America and But I thought it was a crisp two hour practice to wrap up the Redskins first training camp in Richmond
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against Calgary. The first clash with Sidney Crosby in the hand until late November who's who drove returns to DC and the ducks on December 23. And the caps host Detroit at 1230 on Super Bowl Sunday. You're CSN Washington caps insider formally
Ten Ohio State Michigan owned. We then went out west to see how would play out there. Southern cal Washington. Now. And Oregon home side. And so what's happened since smoke. Everybody's. It's also attracted the pop Warner and grassroots levels
Kelly: 'Nothing to gain' from picking QB now
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Oregon given probation for recruiting violations
Chip Kelly's former program has lost a scholarship and was placed on probation for three years.
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