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Simple homepage for a new client. Just trying some things for now:) I kinda like the company colors (green/yellow).
What you guys think of this first attempt? Really want some feedback on this one... This page doesn't include all the components yet...
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Family arrested after out-of-control traffic stop
An officer is on paid leave while police investigate an arrest that escalated quickly when a suspect's family arrived on the scene, and were ordered to the ground.
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PoliceOne top 5
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- 4 Police warn public against using iPhone cases shaped like guns
- 5 Video: Cuffed Ark. woman steals, crashes cruiser

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Which ones are your favs?
Which ones are your favs?
Welp…it looks like I'm having another one. And it's bad. I'm assuming it's just my skin wanting to attack me for whatever reason. I've been drinking my daily 64 oz of water and taking my daily vitamins. Then again, my dermatologist has prescribed me a new cream and perhaps my skin is having a reaction to that.
So I stopped using it and switched over to Alba Botanica's Natural ACNEdote Deep Pore Wash.
An all natural acne cleanser? So up my alley!
It's not every day that you'll run into an acne cleanser that DOES NOT contain harsh ingredients. Which is kinda loco because if your face is already breaking out like mad, the last thing you need are unnecessary and super harsh ingredients. Especially if your skin is sensitive.
But leave it to Alba Botanica to change the game. Please oh please, darlings…tell me you're familiar with this brand. If you're like me, you may have passed them by in Whole Foods or your favorite health food store. But girlfriend, the next time you are mindlessly shopping, check them out!
My skin has been absolutely loving the wash. Check out what it does NOT have.
The fact that it doesn't have any artificial fragrances has me dancin' in the streets. Since it contains willow bark extract, (which is a natural source of Salicylic Acid) it has a natural and earthy smell that I find pleasant and not too overwhelming.
It also contains lemon balm and parsley extracts. Those kiddos act as natural oil blotters…which, I love! So yep…to my sista girls with oily skin, this wash may be up your alley as it cleanses your skin thoroughly but doesn't over-strip it. It's like the perfect balance. Yin and yang, homies.
I'm also digging the consistency of the wash. It reminds me of castile soap in that it feels water-based. But it doesn't have the richest lather. Which definitely isn't a flaw in my book.
Has this dramatically changed my skin and cleared up my acne over night? Nope. But then again, what does? When you suffer from acne, you know you have to be patient. Has it kept the oily pores at bay while thoroughly cleansing my skin to prevent more pimples? Yeppers! And for that I will forever love and shout to the rooftops about the awesomemess of this cleanser.
And it's only $9.95 for a 6 oz bottle. Not bad at 'tal. The ACNEdote line also has a scrub, moisturizer, gel and astringent. I am so on it.
Any Alba Botanica fans? The lip balms look dreamy. I think I'll scoop one up the next time I'm in Whole Foods attempting to say no to the vegan chocolate chip cookies.
Which, by the way, I always fail at. Womp!
Peace, love and healthy skin!
[Editor's note: This is a re-post from my natural hair blog Loc Rocker. The information was just too grand to limit to just one blog. Very rarely do my blogs cross paths but in this instance…it was inevitable. For all things natural hair, Loc Rocker (and the fabulous blogs on the site's blog roll) is the place to go.]
While I like to travel nationwide for beauty industry events, lately I've been wanting to be more active in the Greater Orlando community. It was at one of my Urban League Young Professionals meetings where I met Karen, the founder of Peace and Beauty Project. Karen's passion for helping young girls and natural beauty fell in line with so many of the things that I am trying to do. I feel so blessed to have crossed paths with her.
Two weekends ago I asked Karen if I could help with her Natural Beauty Lab event. I helped with the preparation and took photos. O.M.G….the event was a HUGE hit.
The event was hosted in the dining hall of a beautiful bed and breakfast in downtown Orlando.
The first thing we blended was a Black Cocoa Butter shampoo.
And yep, it smells and feels as good as it looks. We started off with unscented castile soap.
We then funneled a bit of black cocoa butter.
We dumped in some aloe vera…
And at this point, we were able to scent it however we liked. Cocoa Absolute was a huge hit among most of the ladies.
….I ventured more to the mint essential oil, instead. I just LOVE how mint feels on my scalp.
And bam! A homemade organic black cocoa butter shampoo…
I haven't washed my hair yet (ironically I washed it the day before, womp!) but the next time that I do, I will be using this. Can't. wait. In the meantime, I've been using it as a hand soap and has been leaving my hands incredibly smooth…a rarity when you use castile soap solo.
We made other products but I don't think I took enough pictures of everything. I volunteered to be photographer but somewhere between laughing it up with everyone, live tweeting and mixing, I forgot.
Check out the darling baby beauty in the house. She is the daughter of a fellow blogger, Scottie…over at The Basics. Also in the house was Ortancis from The Orlando's Natural Hair meetup group and Fara from Pure Essence Body Care. I've raved about Pure Essence before when I discovered them at Whole Foods' farmers market. And Fara's locs…O.M.G. I'll be featuring her soon. On Loc Rocker, of course.
If you are in or around the greater Orlando area, shoot an email to email@example.com. The Peace and Beauty Project will be having more events. And did I tell you about Orlando's 1st Beauty and Natural Hair show? That's a post for another day but I am beyond excited.
Peace, y'all. And beauty.
Welcome to another post of Amor de Lacquer….the series all about nail polish and nail care! Send me your requests, suggestions and ideas to firstname.lastname@example.com.
Anxious to see what our favorite affordable and big 3 nail polish brand has for Fall?
Is this terracotta? I'm not sure but I LOVE this burnt orange. It is indeed a fabulous Fall color. It almost reminds me of sweet potato pie. But that's just the Southern girl in me. I could eat sweet potato pie every day until I die. No lie. Hahaaa!
I went to a private school, charter school and public school. Random B fact for ya. And I wasn't even allowed to where red polish until I was practically in high school. This is a true red. Nothing you haven't seen before.
…it's a smoky gray green. Gorgeous!
Go Diamond Cosmetics! I like this collection. The more I review their nail polishes, the more I like them. The collections are stellar and the formula is great. You know what's missing though? Awesome packaging! I'd love to see Diamond Cosmetics nail polish bottles in the shape of diamond…or somethin' like that. Who knows what the future holds. Click the photo at the bottom to start a shoppin'!
Diggin' any of these colors?
Your fellow nail polish junkie,
I've had my eyes on Lavanila products for quite some time and I am so glad to finally be able to share them with y'all. But first, the etymological nerd that is me hasto tell you about the name LAVANILA. It comes from the country of Madagascar. Their native word for vanilla is lavanila. Apparently the best vanilla comes from the island of Madagascar. Pretty cool, uh?
The brand was started by Danielle Raynor and Laura DiGirolamo, both beauty lovers who were frustrated with the perfumes that aggravated their allergies.
And so together (with the help of chemists, of course) they birthed a healthy fragrance.
Call me crazy, but I wasn't aware of all of the synthetic ingredients that were put into fragrances. It's amazing how divine a fragrance can smell using Mother Earth's treats.
The Healthy fragrances are come in 4 different scents and they are all formulated without
– Sulfates
– Synthetic Fragrances
– Synthetic Dyes
– Petro-Chemicals
– Phthalates
– Triclosan
Lavanilla Lavender has notes of vanilla, lavender, rose absolute and violet leaf. Mama Clumps would fall for this as she loves anything with lavender in it. A 1 oz bottle of eau de parfum spray will run you $38 and the 1.7 oz bottle goes for $58. While the vanilla scent does seem to be a little overpowering, I will say that Lavanilla has turned me into a perfume snob. I don't think I'll be looking at mainstream fragrances the same.
And then there are their body butters.
Oh la laaaa….
I don't usually pull out body butters until the weather gets cooler, but I've been making an exception for this kid.
These are perfect after a warm shower or bath as they melt right into your skin.
They are divine, I tell ya. Non-greasy and the scents last. And just like their big sister, they are formulated without all of the nasty stuffs.
The body butters also come in the same 4 scents as the fragrances. Retailing at $12 for a 2.75 bottle and $25 for a 8 oz bottle, I don't think it's a bad steal for my ladies who prefer to use products free of synthetic ingredients. And you have to be a lover of vanilla because all of fragrances and body butters have strong notes of it. I have never been the biggest fan of smelling like a cookie but it is starting grow on me.
Lavanila will see me again as I totally plan to try their healthy deodorant and healthy sunscreen. Loves it!
Have you tried any of their products? Whatcha think?
It's been forever and a day since I've featured a just ONE nail polish in the Amor de Lacquer series. But Ingrid is one of those colors that I feel needs a post on her own. Truth is, I knew I wasn't going to be the biggest fan of this polish but I purchased it. Because for whatever reasons, I kinda dig weird colors on my nails. And if this ain't weird, I don't know what is.
Ingrid comes from China Glaze's Vintage Vixen Fall 2010 collection. It was the one color that stood out to me. It's like an ashy brown with gold flecks. At least that's what I see. China Glaze's description says that Ingrid is a light brown with copper, pink and green micro glitter.
It is such an interesting color and even if I don't wear it often, I'm glad to add it to my collection. I've featured brown polishes before. Remember Nubar's Chocolate Truffle collection? And then there was OPI's higly coveted You Don't Know Jacques. Which, I STILL don't like. But there's something to say about Ingrid.
I think it works with my skintone. And it applied flawlessly! More shots of Ingrid around town…
How is this for a design fail?
Uhh, I'll stick to perfecting konad and simple strips and dots. I purchased this gal from transdesign.com for $2.99. So what do you think? Would you rock Ingrid? Have you snagged any of the other polishes from the Vintage Vixen collection?
Oh! And I picked up Sephora by O.P.I's Studs & Stilettos, another brown polish. I guess I'm goin' through a phase, y'all.
Your fellow nail polish junkie,
Very rarely do I have to do disclaimers on my posts but for those of y'all that are squeamish about liquid going up and out of the nose, you may not want to read any further. I have pictures showing it alllll.
Yep, I love you too.
For those of y'all that have hung around, allow me to share with you the power that is the neti pot.
Looks like Aladdin's genie lamp 2010, uh? While an actual genie won't pop out and grant you three wishes, the neti pot does provide an insane amount of nasal and sinus relief.
I know what you're thinking…WHAT in the world does this have to do with beauty? I'll tell you what's not beautiful, sinus migraines and under eye discoloration; two things that regularly using a neti pot can alleviate. Follow me as we take a journey up my nose. Literally.
So how does a neti pot work?
For starters, nasal irrigation or the flushing out of mucus and debris from the nasal cavity and sinuses is not a new concept. Its origin began in India and South East Asia and has been around for centuries. (source) The concept is simple. Using warm water and saline solution in your neti pot, you simply tilt your head and allow the solution to go up one nostril and out of the other.
Looks weird, uh? Wellll OBviously, it's not done at the dinner table on a date but as needed in the comfort of a bathroom.
Saline solution comes with your neti pot and they can also be purchased separately.
But don't be cheap like me and try to use half a packet of a saline solution. It burns like the dickens! I was screaming for Mommy and Daddy when I accidentally did that. No bueno.
Neti pot instructions….
OMG, what if I choke?
You won't. Unless, of course you panic. But then again, the same could be said for drinking a glass of water. The key to using the neti pot is to relax. Don't rush, don't hold your breath and don't swallow 4 times in one second. I find that making the K-sound (as in kite) really helps me from accidentally swallowing the water.
Uh, what comes out of your nose?
Boogers. LOL, I'm kidding. Once the saline solution travels from one nostril, through your sinuses and out of the other nostril, you won't see much of anything except perhaps mucus and saline solution. I've seen lint (maybe from a towel or pillowcase) before.
Wait, what's the point of this again? Who can benefit from using a neti pot?
Anyone! We brush our teeth, clean our ears and bathe on a regular, why not clean out the nasal passage every now and then? It has also been said that using a neti pot can help diminish under eye circles and can alleviate stuffy noses. I've used my neti pot with stuffy noses but it doesn't seem to work. If one nostril is all stuffed up, the water has no where to go. Opps! And while I don't have allergies, I can only imagine how golden a neti pot would be for allergy sufferers. As a chronic sinus headache suffer, the neti pot has changed my life. I always look at holistic, herbal and homeopathic remedies before OTC and prescribed medication so the neti pot is right up my alley.
And you shouldn't use it every day. Too much of a good thing can be a bad thing. I use mine at least 3 times a week.
I want one!
You can get the SinuCleanse neti pot at most drugstores and natural food stores. They are super easy to find and will run you about $11.99 USD. Aaaand, you can try and win one from me. I love my neti pot so much that I decided to give TWO readers a chance to snag one of their own.
Here's what you have to do:
If you have any questions, email me at email@example.com. Good luck!
Y'all know I love concealers, right? When I find a good one, I hold on to it for dear life. Because I'm not the biggest fan of full coverage foundation, I have to have a good concealer. One that provides me light coverage, won't clog my pores and won't evaporate in Florida's insane humidity.
That said, I was SO happy to hear that the COVERGIRL Queen collection released concealers that are brown girl friendly.
Hallelujer! Drugstore concealers for brown girls? "Where dey do that at?" Peep this…
This lightweight non-acnegenic concealer comes in 4 shades; Light, Golden, Terra and Cocoa. The sponge tip applicator takes some getting used to.
I never know how to use this. Do I dab it on my hand and apply using my fingers or a brush? Or is it okay to simply swipe the concealer directly on my cheeks? What is your preference?
Either way, I find it to be smooth and light. My best shade for me was Cocoa. For reference, I am NW45 in MAC Cosmetics.
It blends right on in and gives me the day-to-day coverage that I seek without looking "too made up."
I am able to dust a translucent powder over my cheeks and I'm good to go. And somehow…it manages to last ALL day. I'm impressed! Not bad for $8! You go, COVERGIRL Queen!
Whatcha think? Are you a concealer wearer?


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Source: Undercover Tourist
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Tuesday, 17 Apr 2012 01:49 PM
General Services Administration witnesses came under sharp criticism from Congress for a second day on Tuesday, as lawmakers expressed outrage over junkets, bonuses and parties paid for by taxpayers.
Questioning ranged beyond the $823,000 paid for a Las Vegas conference in October 2010, to a culture of the nation's government real estate agency playing fast and loose with taxpayer money.
Members of the House Transportation and Infrastructure subcommittee asked about trips to the South Pacific, the Napa Valley wine country and to Las Vegas to plan for the October conference.
GSA officials landed special deals with resorts that got them suites, where parties were held on the taxpayers' dime. There were missing electronic devices such as iPads purchased for prize ceremonies.
Inspector General Brian Miller, whose report on the Las Vegas conference touched off congressional investigations, almost seemed overwhelmed by the scope of wrongdoing.
"Every time we turned over a stone we found 50 more with all kinds of things crawling out," Miller said.
Rep. Jeff Denham, R-Calif., who chaired the Transportation subcommittee hearing, summed up his frustration and that of others by telling GSA witnesses the agency suffered from "this culture of fraud, waste, corruption" and possibly cover-ups and inside deals with vendors.
"This certainly is not only a dark day for GSA but a dark day for the U.S. government. We wonder why there is so much distrust in government," he said.
The host of the Las Vegas conference, Jeffrey Neely, invoked his right to remain silent at a hearing Monday and did not appear Tuesday in response to an invitation. His nametag was at the witness table for a time, and then was removed..
Miller referred Neely's case to the Justice Department for a criminal investigation, among others. The internal watchdog said he's investigating bribery and kickbacks and already has recommended criminal charges be filed.
Miller said 115 electronic devices purchased for GSA prize ceremonies were missing, and one was traced to a daughter of Neely.
Other questions focused on why officials needed 9 so-called planning trips for the Las Vegas conference.
"In my opinion the pre-planning trips were not justified," Miller said.
Other trips were taken, many by Neely and his wife, including a nine-day trip to Hawaii.
A fired official, testified he didn't know taxpayers would be billed $1,960 for a party in his luxury suite at a Las Vegas resort.
Robert Peck said he had paid for some food out of his own pocket and was surprised when additional food arrived — eventually paid for by taxpayers.
The agency's new leadership has demanded the amount be repaid and Peck said he would do so.
Peck was fired as Public Buildings Commissioner after the inspector general reported some $823,000 was spent at the conference in violation of agency rules. He said he didn't condone the conduct of others, but was let go because improprieties occurred on his watch.
Peck also was asked why he only approved a tepid letter to Neely for his improper travel and allowed him to receive a $9,000 bonus.
He said he acted on information he knew at the time.
© Copyright 2015 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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3T Brezza Team II Aerobar - Road Bike Shop
Road Bike Shop
Product Search Results For "3T Brezza Team II Aerobar"
|3T ARX II Team Stealth Stem
There's a time and a place for loud and flashy. Sometimes that place isn't the cockpit of your bike. The 3T ARX Team II Stealth Stem adds a touch of elegance to your cockpit with a subtle, matte black finish that downplays the Team stem's stiff, lightweight performance. The Arx II Team continues...
Price: $119.95
|3T ARX II Team Stem
The original 3T ARX stem quickly became a classic due its strength and versatility. Since its arrival in 2007, we've watched it find a place on every sort of bike, from road to mountain. The new ARX II Team Stem refines 3T's classic design, offering sculpted sides and a sleeker faceplate. 3T's...
Price: $109.99
|3T ARX II Team Stem
The 3T Arx Stem originally appeared in 2007. Since then this model has enjoyed continuous subtle refinement. The Arx II Team continues the original's tradition of simple, classic construction -- but with a design that drops grams from its already low weight. The 3T Arx Team II Stem takes the...
|3T Brezza II LTD Nano Handlebar
When you're time-trialing, you want to be aero for every second of the race. Unless you're making a technical turn or on the start ramp, your elbows are down and your hands are wrapped around the extensions. This aero tuck position is equally as important for triathletes or track cyclists who...


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Use the tools below to refine your search by only displaying reviews with a certain number of star ratings or to only show reviews from a certain time period. Eg click on '1 star' to just display the reviews we have which received a 1 star rating click or 'Within the last month' to display just reviews posted over the last month.
Written on: 23/03/2014 by Giadap289 (1 review written)
IT TOOK THE P! BEEN WAITING FOR AGES GETTING LATE FOR A DATE. FCUK MEGABUS… Read Full ReviewVisit megabus.com
Written on: 20/03/2014 by Angelinab1961 (1 review written)
am so angry, i cant believe megabus service can be so poor. my husband took the 3.30am bus to from manchester to london for an interview which was booked 9.am, d bus was suppose to be there at 8, nut due to changing driver twice and other delays they didnt get to victoria till 9.02 even thought he begged the driver to let him get off so i can use the unground the driver refused. my husbamd then took a taxi to the interview which was in casmberwell but he was too late and they refused him… Read Full ReviewVisit megabus.com
Written on: 18/03/2014 by Quincyh136 (1 review written)
I was a first time user of MegabusGold, the sleeper service. I booked a return from London to Edinburgh. Twenty minutes before my departure we were told the sleeper bus had broken down and our replacement would have seats, not bunks. I had a job interview in Edinburgh on the saturday morning and needed to arrive fresh. Instead I had to spend the night in a cramped seat. On my return from Edinburgh two days later all seemed well. We boarded the sleeper coach and got in our bunks (really… Read Full ReviewVisit megabus.com
Written on: 13/03/2014
orderd tickets of 2/1/2014. had to cancel, was told i could use my ticket at another time. when i called to use at laer date. was not allowed to . had to buy another ticket. still looking for my refund. order number ACDGHTQ and ACDF30Y. a total of 99.00. On a fixed income this is aweful. … Read Full ReviewVisit megabus.com
Written on: 07/03/2014 by LouisR (1 review written)
Decided to give Megabus a try to go to NYC from Syracuse. Bus arrived about 20 minutes late, and was already half-full of passengers from Rochester. The bus completely filled up with more than 50 people still waiting in line in the 20 degree cold, and they had no idea if or when another bus would be coming. I called customer service twice 30 minutes apart and was told both times "We're not the dispatchers, so we don't know. Call back in 15 minutes." When I asked for a refund so we could take… Read Full ReviewVisit megabus.com
Written on: 07/03/2014 by Huffman105 (1 review written)
6/3/2014 I did travel by mega bus. My first trip it was 50mins delay on run. Because run out of fuel. Bus run by experienced driver. Quick and fast, but it stings from toilet. Was really hard to breath. Very narrow sit, absolutely uncomfortable, and most terrible thing is didn't give any break for 6 hours journey. As far I know you are not allow to drink or eat in bus. How can someone can travel for 6 hours without any drinks or eat????? And on my return back to Liverpool. Guess what, nothing… Read Full ReviewVisit megabus.com
Written on: 06/06/2014
Hot food and alcoholic drinks are prohibited on Megabus. There is no other bar on eating/drinking.
Written on: 04/03/2014 by Kendrad337 (1 review written)
The bus to London was delayed for one hour and instead of getting us there asap they wanted to pick up passengers from Bristol too! They lied to us because they didnt have enough passengers and they said the bus was broken sorry! Thats it!… Read Full ReviewVisit megabus.com
Written on: 06/06/2014
If a service is scheduled to pick up from Bristol it will do so however late it is running.
Alternatively if a bus intended for the Bristol passengers had broken down and the driver of your service was instructed by megabus control to divert there to pick them up then he would do so.
These things happen and choices made will not suit everyone.
Written on: 03/03/2014 by livvy786 (1 review written)
I am travelling whilst writing this on a megabus , no heating , no electric supply to plugs, no loo roll !! By all accounts no interest of driver !! First and most definitely last time !!… Read Full ReviewVisit megabus.com
Written on: 03/03/2014 by LitreeW (1 review written)
I have used the megabus more then a few times to get family members back and forth to visit me in the Iowa City Iowa area. My daughter traveled from Memphis TN, my brother from Aurora Il. My sister and mother along with nieces from Mississippi. And each time it has been the worst experience ever! From customer service to the bus drivers. My brother has been to visit 3 times using the megabus. Coming out of Chicago into Iowa the bus was late but only about 15-20 mins. But all 3 time leaving… Read Full ReviewVisit megabus.com
Written on: 26/02/2014 by amydouglas1992 (1 review written)
I have been using the Megabus service from Birmingham to Newcastle and back for 3 years now. It is fair to assume that you, 'get what you pay for' when it comes to the customer service - which needs greatly improving. The Megabus itself has improved over the years with free wifi and more room. However, two weeks ago I had my luggage taken from the hold underneath the bus. I thought this was by accident as a bag was left behind which looked very similar to mine. The customer service line that I… Read Full ReviewVisit megabus.com
Written on: 24/02/2014
Travelled from Victoria coach st to cardiff 2 weeks ago then done the return jorney back again 6 day's later , the 2 driver's were very helpful and polite , was given sandwich and drink halfway through the journey this was fresh! Considering how small the toilet was and wash basin it was very clean! It wasnt to cold and all in all a very pleasent journey and helpful carful hand with my case will definitely be using again and recomend highly !would just like to say thankyou for letting me get… Read Full ReviewVisit megabus.com
Written on: 23/02/2014 by hatinginjustice (1 review written)
I got a bus from Atlanta to DC with transfer in Charlotte. Well the bus breaks down and is an hour and half late to pick us up. Call to ask what to do whole time on bus they say can't do anything until I get to Charlotte. Get to Charlotte and the tell me they won't do anything for me because I should have book a bus with a two hour window. They say its in their policy but no where can I find. So they tell me I have to purchase another ticket full price. Also next bus doesn't leave until 10pm… Read Full ReviewVisit megabus.com
Written on: 24/02/2014
They tell you that you need at least 2 hours in their FAQs and in their terms and conditions. Thats the same for airlines. Delays can happen on the road so its best to book with a good layover to be safe
Written on: 22/02/2014
I was stood at the Newport bus stop last night at 6pm...the bus was 47 mins late.. it was so cold and id missed my lift at victoria by then so I had to come home.. I feel ill today and requested that my ticket be reinburst for nxt week but they dont give a hoot...National express have a great customer setvice...megabus treat u like their seats...CHEAP! NEVER USE THIS SERVICE AGAIN AND WOULDNT ADVISE ANYONE ELSE To. THANKS G… Read Full ReviewVisit megabus.com
Written on: 20/02/2014 by JulieHancock (1 review written)
What was intended to be a complaint about a previous trip has gone forth and has turned into a positive email. I was a passenger on the 17:30 London service from Manchester last Sunday 16th February. I want to congratulate megabus for many things today. The coach was spotless and the toilet fresh and clean. And with my past journeys i was in shock to what i witnessed today. I am used to coach lateness a grumpy driver and a toilet that is not fit for use. However the driver greeted everyone as… Read Full ReviewVisit megabus.com
Written on: 17/02/2014
We went on the gold service. Don't believe the photo. Our seats were the same old rubbish. No space no table - useless. Driver rude but did nearly apologised after I asked him not to speak to me. Meant to be non stop but already stopped once and not left the city yet! Using 3G to write this as the wifi is also useless. Don't use this very second rate service would be my recommendation. There is nothing to like about this service… Read Full ReviewVisit megabus.com
Written on: 15/02/2014 by reviewer123458 (1 review written)
If I could put zero stars I would. Website gave wrong directions to the bus stop so we pulled up as they were leaving. We spoke with an incompetent customer service rep who guaranteed I would receive a refund for the return trip and I would get a response within a week. They didn't respond until an entire month later to tell me that I can cancel my trip at any point 24 hours prior to trip...which has absolutely nothing to do with the issue at hand and they also spelled their own company's name… Read Full ReviewVisit megabus.com
Written on: 12/02/2014 by EmmaNeal (1 review written)
Having used Megabus for the first time over the weekend (7TH FEB 2014- 11TH FEB), I WOULD definatly use them again, They were on time (early infact) buses were very clean and tidy, Drivers were dressed smart and polite and friendly. Atmosphere was amazing and got talking to fellow commuters, The only thing I would recommend is take plenty of fluids and dont stop long enough to grab a drink. I will be using Megabus again as so good and value for money. hope this review helps others… Read Full ReviewVisit megabus.com
Written on: 11/02/2014
I booked a bus trip at 345am. Bus never came. I called and called Megabus to see where the bus was or to let them know that hey I am driving to next bus stop 2 hours away....to let them know that the bus never came. I had to find parking and ride rail to bus stop in Atlanta only to NOT BE LET ON BUS. I knocked on door and LADY SHOOK HER HEAD NO! she would not even listen to why I was not there 15 min before. WORST-RUDE-UNPROFESSIONAL I called and finally spoke to someone (they open at 630am)… Read Full ReviewVisit megabus.com
Written on: 13/02/2014
It's really terrible be careful when u buy a ticket from online if u put same date n time to go n return back also accepted in other bus company when u go somewhere n comming back time should be matched otherwise u cant buy a ticket.
Written on: 11/02/2014
I have used megabus quite a lot over the last 2 years. The only issue is coaches 6/10 Times turn up late. They don't stop for breaks what I find awful as if your traveling between Newcastle & London your stuck for over 7 hours. They don't even provide a coffee service what I would like to see in the future. They also need to change there check in process as its a little push and shove. Fares start at around £3 - £5 on Wednesday. What is a bargain. The M36 (NEWCASTLE - LEEDS -… Read Full ReviewVisit megabus.com
Written on: 24/01/2014 by Flava1 (1 review written)
Megabus used to offer excellent services on their London to Sunderland/Newcastle terminal but recently it's gone down the hill. They now use trashy buses for that terminal, most times buses with no heating system, AC power sockets and possibly wifi for 6hrs 30minutes journey. Well as for me I will never use Megabus again, time to go back to national express… Read Full ReviewVisit megabus.com
" Very disappointed " Read More
" Very rude bus driver !! " Read More
" The worst ever " Read More
" Special offer for one person, can't seem to book for two peo " Read More
" Diabolical so called timetables " Read More


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Not very much is known about this shinobi, other than the fact that he is a new member of the Akatsuki, as he took Sasori's position after he was killed by Sakura and Chiyo. He seems to act like a pretty innocent and polite person, and even a little clumsy at times.
His true identity is unknown, as he has yet to have been exposed without his mask yet, and his origination has not yet been revealed. Though it is apparent that he somehow possesses the Sharingan. Leading many to believe he could possibly be Uchiha Obito, due to the fact he only seems to have one eye (Obito gave one of his eyes to Kakashi). However there is no proof or claims of this yet. He did however claim to be Uchiha Madara, in a conversation he had with Pein, but it is unknown if he meant he is Madara in-person, or in some other way.
After joining the Akatsuki, his first assignment was to capture the Three-tailed Turtle jinchuuriki, along with Deidara. The couple managed to restrain the jinchuuriki and transport it back to the Akatsuki's hideout, where Tobi then proceeded to brag about how he defeated the demon with a one-shot knockout technique. Which seemed to be a little bit over-exaggurated.
Him and Deidara later on went on a mission to kill Sasuke, due to the fact that Deidara had always wanted to kill Orochimaru, who had been previously killed by Sasuke. Once they finally met up with him and confronted him, Sasuke made an attempt to cut Tobi in half with his word, after which Tobi got back up, completely undamaged. Tobi was more of a peer in the fight, until being requested to help set up explosives by Deidara. Deidara set off his C4 explosive, which was thought to have killed Tobi in the crossfire. However it is apparent now that he had survived.
Comments: 12
|Tobi is madara.... proven in the anime where he shows kisame his face and kisame says" oh so you are him after all huh? madara uchiha?" or something on those lines... and the part where he showed sasuke his face.... even itachi knows tobi is madara.... read book watch anime is all i gotta say...
Comments: 12
|Ok ppl i need help here. my friend (coughs) chloe believes tht tobi is obito which is soooooo not true i believe tobi is madara so if u can give me info to prove tobi is madara like the manga book chapters and episodes proving he is madara plz type it here and tell me
Comments: 12
|tobi: u cant see my face..... but u can see my but! deidara: ........ (tobi runs behind a tree) tobi: ima school girl in love with her senpai! (yeah wht r u trying to say by that huh tobi the schoolgirl???)
Comments: 1
tobi is mad.he is not beaten by any jutsu but he is good
Comments: 12
|epic shark!!! hahahaha! just kidding just kidding! tobi is madara a
Comments: 3
|juz wait until konohamaru break his mask along with his face..
Comments: 1
|tobi is definitely uchiha madara using obito's body.he's just pretendin' 2 b actin' childishly so as nut 2 b suspicious!'
Comments: 93
Comments: 12
|Tobi is an orange lollipop! (hes one of my fav. characters.... no offense!)
Comments: 4
|he is madara he says it himself in book 43
Comments: 32
|dionnuortizu is right my elder brother who watched it a long time ago said the exact same thing .... wierd
Comments: 22
Comments: 74
|tobi is madara no doubt about it
Comments: 14
|Tobi is a beast
Comments: 2
|i dont think tobi is madara because in chapter 559 of the manga madara is resurrected using the impure world resurrection jutsu and i dont think you can use that jutsu on some one that is alive me and my brother think that tobi is either obito or madaras brother whis name i forget


text:
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July 07, 2015
Tony Award winner Adriane Lenox, Grammy Award winner Fantasia, and Emmy Award nominee Dulé Hill are returning to Broadway in After Midnight, the new revue celebrating Duke Ellington's years at the Cotton Club, beginning performances Oct. 18 at the Brooks Atkinson Theatre. Hill serves as "The Host" for the evening, leading the audience through the heat and glamour of the Harlem Renaissance using the words of Langston Hughes. At a recent preview that included a performance by the 17-piece Jazz at Lincoln Center All-Stars, Playbill spoke to the three stars about their history with jazz, and why they're excited to bring the music to Broadway. For more on After Midnight, visit PlaybillVault.com.
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30 Jun 2015
Jennifer Hudson Will Break Your Heart With This Color Purple Song – Listen to It Here!
30 Jun 2015
Stephanie J. Block and Carolee Carmello Among Broadway Actors Who Will Sing Unplugged at Town Hall
30 Jun 2015
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22 Jun 2015
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After Midnight Star Will Headline Dreamgirls at Milwaukee Rep
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CNBC's Dominic Chu looks at how the markets are likely to open tomorrow, following the Greek no vote.
Peter Costa, Empire Executions offers his perspective on how the markets will react tomorrow. Michael Farr, Farr, Miller & Washington, weighs in.
Bernard Lietaer, professor of Sustainable Territorial Development Program at the Pantheon-Sorbonne University, discusses Greece's rejection of the bailout terms put forward by its creditors.
Jared Bernstein, senior fellow at the Center on Budget and Policy Priorities, says the referendum's results have the potential to change the dynamics of the negotiations between Greece and its creditors.
Fraser Howie, managing Director of Newedge Singapore, says China's government shouldn't have meddled in the stock market, adding that the market rout is endemic of other issues in the economy.
Kaori Ejoji of CNBC Asia discusses how the Asian markets have reacted this morning to the Greek no vote.
CNBC's Sara Eisen says a lot of people are blaming the IMF for Greece's situation. The country is in arrears, but will the IMF ride to the rescue?
Dan Greehaus of BTIG says this is another of unfortunate events that have hampered the world economy over the last few years. With CNBC's Michelle Caruso-Cabrera.
It's fine for the European nations to tell Greece what must be done, but how do austerity and today's vote affect people who live there?
Dan Greehaus of BTIG says people were caught off guard by the Greek no vote and what happens now. The dollar will become a safe haven, he says.
CNBC contributor Ron Insana looks at whether investors should be more concerned with China, Greece or Puerto Rico?
Christian Menegatti, Windhaven Investment Management, answers the question of whether Greece will stay or leave the euro zone.
Simon Warner, head of Fixed Income at AMP Capital, discusses how the overwhelming Greek rejection of a bailout could impact the global fixed income space.
CNBC's Sara Eisen discusses the impact of the Greek vote on currencies.
CNBC's Dominic Chu discusses the impact of the Greek vote on the world markets and futures.
Wolfgang Piccoli, Teneo Intelligence, discusses how the Greek people are dealing with the lack of money and banks being closed.
CNBC's Michelle Caruso-Cabrera looks at the odds of a Grexit, now that the Greeks voted no on new austerity measures. With Wolfgang Piccoli, Teneo Intelligence.
Vassili Serebriakov, currency strategist at BNP Paribas, says the euro has become a funding currency which means it is now negatively correlated with risk.
Even though the Greek government has a mandate now, the Eurogroup holds the key to financial aid so Greece has to blink first, says Angel Ubide, senior fellow at Peterson Institute for International Economics (PIIE).
Discussing the future of Greece and the euro, with Raoul Ruparel of Open Europe.
While Wall Street will reopen to volatile trade on Monday, Masood Vojdani, founder of MV Financial, advises U.S. investors to stay patient as the Greek situation will likely be resolved soon.
Michael Jacobides, associate professor of strategy and entrepreneurship at London Business School, explains why the 'No' vote didn't help Greek Prime Minister Alexis Tsipras out of a political corner.
Over 60 percent of Greeks voted 'No' in a referendum asking them to accept new financial aid on Sunday. CNBC's Julia Chatterley has more from Athens, while Geoff Cutmore reports from Brussels.
Standard & Poor's chief rating officer Moritz Kraemer, discusses the likelihood of a deal "Grexit."
Thanos Vamvakidis, BofA Merrill Lynch, provides perspective on the "no" vote in Greece, which asks their government to turn down a proposal from its creditors.
Insight to how the historic "no" vote in the Greece referendum is showing up in Asia markets, with CNBC's Adam Bakhtiar.
European Parliament President Martin Schulz addressed the results of the Greek referendum on Sunday evening.
CNBC's Julia Chatterley speaks to Teneo Holdings' Wolfango Piccoli, about plans by European leaders, including Germany's Merkel and France's Hollande meeting on Monday, and the ECB.
Member of the European Parliamen David Campbell Bannerman, says Greece leaving the euro would be "bloody," but would be better for the country.
Panicos Demetriades, former Governor for Central Bank of Cyprus, discusses the difficult issues with Greece's debt.
Get the best of CNBC in your inbox
Greek Prime Minister Alexis Tsipras is speaking after the Greek people voted "no" in the referendum, which rejects the proposals of the country's European creditors.
CNBC's Julia Chatterley reports on the celebration in Athens in support of the "no" vote leading the referendum.
CNBC's Karen Tso looks at market projections as votes for the Greek referendum are counted. Pippa Malmgren, DRPM Group founder, and, Konstantinos Venetis, Lombard Street Research, share their forecast.


text:
Every Sunday, more than 50 million churchgoers stand, raise their hands and sing songs like I Will Rise, Oceans and Mighty to Save, written by the worship band Hillsong United. ... more
No surprise. ... more
For the owner of Bailey's Pizza in the small town of Searcy, Arkansas, keeping the Scripture and the sausage separate is something he believes he should not have to do. ... more
I love it when Christian parents whose kids haven't even yet made it out of the nest with their faith seriously tried, tested and found true, lecture others about "how to raise godly kids". ... more


text:
In mybook®: Pets
Great Southern Animal Hospital
2685 S High St, Columbus, OH 43207
Closed Now
- Tomorrow
- 8:00 am - 6:00 pm
Galleryn of 1
Regular Hours
- Mon
- 8:00 am - 6:00 pm
- Tue - Thu
- 9:00 am - 6:00 pm
- Fri
- 8:00 am - 6:00 pm
- Sat
- 8:00 am - 12:00 am
General Info
Dr. Dustin Sears has been at The Great Southern Animal Hospital for the past 21 years. He graduated from the Ohio State University College of Veterinary Medicine in 2000. Dr. Sears enjoys what he does and looks forward to helping you and your pet experience a healthy lifestyle.
Located 4 Miles South of Downtown on High St.
Located 4 Miles South of Downtown on High St.
Payment Methods
Great Southern Animal Hospital is close to German Village and downtown. We are centrally located and easy access from many highways. The hospital is located on South High St., four miles south of Broad St. and two miles north of 270 on South High and one mile south of Rt. 104.
•We Care for Small Animals, Dogs and Cats •Full Service Medical and Surgical Clinic •Medical and Diagnostic Services •Dental Procedures •Wellness Exams and Vaccinations •Spaying •Neutering •Puppy Shots •Kitten Shots •Prescription Diets •Prescription Flea Control •Pet Supplies


text:
Hilton Mag Mile Bell, Door Attendants Ratify Three-Year Contract
Bell and door attendants at Hilton Suites Magnificent Mile ratified a new three-year agreement that includes annual raises, improved benefits and several additional work protections.
Union Protects Andrew Distribution Members' Benefits, Working Conditions
Teamsters Local 727 secured a two-year contract extension for Andrew Distribution drivers and clerical workers. The agreement includes annual bonuses and employer-paid benefit increases while protecting all other current working conditions and job security clauses.
MV Westmont Workers Ratify First Teamster Contract
MV Transportation Westmont paratransit drivers and mechanics have ratified their first Teamster contract, which includes raises, job protections and paid sick leave.
Trustees Allocate $3 Million for Educational Assistance Benefits
For the first time, the Teamsters Local 727 Legal and Educational Assistance Fund Board of Trustees has allocated $3 million for Educational Assistance benefits for the 2015-16 school year.
Local 727 Secures Retroactivity Agreement for Coca-Cola Members
Teamsters Local 727 representatives worked tirelessly to secure a strong retroactivity agreement that protects the wages and working conditions for nearly 800 Chicago-area Coca-Cola members while the union works to negotiate a new contract.


text:
Dr. Lance Gault is a family physician in Livingston, CA, providing primary medical care for any member of the family – from seniors to children.
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We invite you to write a review about your experience with Dr. Gault.
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text:
Stay in the flow and don't experience anguish
"Trouble and anguish shall make him afraid; they shall prevail against him."
— Job 15:24
Mostly excerpts of columnists published in The Madera Tribune.
"Trouble and anguish shall make him afraid; they shall prevail against him."
— Job 15:24
I am a big fan of advertising. When I started at The Madera Tribune in 1995, I sold retail advertising. The ad department was the only one with an opening at the time.
On March 2, 1946, a neatly dressed woman stood beside her attorney, John D. Boyle, and intently searched Judge Stanley Murray's face for some hint of what was to come.
Coyote blue. A local came up to me while I was having coffee this week and evidently saw I was reading the sports section of the Fresno Buzz.
After all these years, I never thought I could be stumped by what people will do for diversion, but here's one for considerationd: A cat cafe has opened in Oakland.
Sighs of relief were audible all around California the other day, when the embattled, disgraced Michael Peevey announced he would not seek reappointment to a third six-year term as president of the powerful
Have you ever stuffed a suitcase full of "just in case" items only to find at trip's end you've used only 10 percent of what you packed?


text:
André Barbieri, Sausset Les Pins FR
|Patent application number
|STEPPED INSTRUMENT PANEL FOR AIRCRAFT - An instrument panel for a rotorcraft having two pilot seats, said instrument panel being arranged under an anti-glare shield (
|UNDERCARRIAGE, AN AIRCRAFT INCLUDING SAID UNDERCARRIAGE, AND A METHOD OF LANDING SAID AIRCRAFT - An undercarriage (
Davide Barbieri, Zeist NL
|Patent application number
|INJECTABLE AND MOLDABLE CERAMIC MATERIALS - Disclosed is an injectable and moldable ceramic material comprising porous calcium phosphate having surface-microporosity, and a water-free carrier, wherein the carrier is selected so as to disintegrate under physiological circumstances. The latter refers to the property of a carrier to dissolve, disassociate, or otherwise disintegrate after placement (e.g. through injection or implantation) into the human body. By selection of a water-free polymer or polymer blend which is combined with surface-microporous calcium phosphates, the favourable osteoinductive properties by virtue of the surface-microporosity can be retained for prolonged shelf life.
Gabriele Barbieri, Paris FR
|Patent application number
|METHOD FOR CREATING A MARKOV PROCESS THAT GENERATES SEQUENCES - The present invention relates to a method for creating a Markov process that generates sequences. Each sequence has a finite length L, comprises items from a set of a specific number n of items, and satisfies one or more control constraints specifying one or more requirements on the sequence. The method comprises the steps of receiving data defining an initial Markov process of a specific order d and having an initial probability distribution and of receiving data defining one or more control constraints. The method further comprises the step of generating data defining intermediary matrices, each matrix being of dimension nd by n, by zeroing out transitions in the initial Markov process data that are forbidden by the one or more control constraints.
Mauro Barbieri, Einhoven NL
|Patent application number
|METHOD AND APPARATUS FOR CREATING RECOMMENDATIONS FOR A USER - A method and apparatus for creating recommendations for a user is described. A user input relating to an item is received (step
Mauro Barbieri, Jx Eindhoven NL
|Patent application number
|ADAPTIVE IMPLICIT LEARNING FOR RECOMMENDER SYSTEM - The present invention relates to an apparatus, method, and computer program product for controlling a recommender system, wherein user actions on content items are associated to explicit ratings on these content items and translated into a UI features profile, which is subsequently used by a recommender. This recommender rates new items based on user actions on this item and thus creates an implicitly learned rating history. This learning makes the implicit rating or scoring personalized. It can be combined in several ways with an explicitly learned rating history to improve overall performance and/or to mitigate the burden for the user, by having him/her rate less items explicitly.
Mauro Barbieri, Lc Eindhoven NL
|Patent application number
|AUTOMATIC INFORMATION SELECTION BASED ON INVOLVEMENT CLASSIFICATION - The present invention relates to an automatic selection or placement engine that, given an ancillary information belonging to a certain category, places it in a congruent or contrasting context depending on the degree of involvement of the user in that product category. User profiles are automatically classified as low or high user involvement in a certain category.
Nicola Barbieri, Barcelona Catalunya ES
|Patent application number
|INFLUENCE MAXIMIZATION WITH VIRAL PRODUCT DESIGN - The disclosure includes use of a feature-aware propagation model to identify one or more features of a product and one or more person(s), or members of a social network, to target, or user, for marketing the product having the identified features. The one or more person(s) identified using the model may be the person(s), or member(s), of a social network determined to have a maximum capability, relative to other members of the social network, for influencing the members of the social network in adopting, e.g., purchasing, a product having the identified features. In addition, parameters of the model may be determined using information about the social network, user preferences, and the products and features of the products.
Nicola Barbieri, Barcelona ES
|Patent application number
|Identifying Communities Within A Social Network Based on Information Propagation Data - Methods and systems for identifying communities based on information propagation data are described. One of the methods includes receiving a social graph, which includes nodes and relationships between the nodes. The method further includes receiving a number of the communities to find within the social graph, receiving data regarding propagation of information between the nodes, and calculating a probability of formation of a link between a first one of the nodes and a second one of the nodes based on the data. The link provides a direction of flow of media between the first and second nodes. The method includes calculating a probability that media will be accessed by the second node based on the data. One of the communities includes the first node, the second node, and the link.
Philippe Barbieri, Lyon FR
|Patent application number
|Apparatus and Method for the Continuous Pickling of Steel Strip - The pickling of a continuously running steel strip and, more particularly, a pickling method, includes centralized control of all of the pickling operations. The invention further includes an apparatus for implementing the pickling process.
Salvatore Federico Barbieri, Ottawa CA
|Patent application number
|Verifying a Wireless Device - In some aspects of what is described here, a first wireless device detects proximity of a second wireless device (e.g., by a Near Field Communication (NFC) interface or another type of interface). Based on detecting proximity of the second wireless device, the first wireless device generates a recommendation request from information received from the second wireless device. The first wireless device sends the recommendation request to a trusted authority and receives a response. The response includes the trusted authority's recommendation whether to trust the second wireless device. The first wireless device can determine whether to trust the second wireless device based on the recommendation.


text:
Field Trips and Events
Special Events
Canoe the Mississippi
Hidden Falls Park, St. Paul, MN
August 22, 2015
Overview: Canoe the Mighty Mississippi with The Nature Conservancy and outfitter Wilderness Inquiry. Flowing through the heart of the Twin Cities Metro region, the Mississippi River offers unparalleled opportunities for viewing wildlife, learning about nature, a... Learn more
Rare Orchid Hike
Pembina Trail Preserve near Crookston, MN
July 11, 2015
Hike our Pembina Trail Preserve, an exceptional tallgrass prairie remnant which is home to one of the nation's best populations of western prairie fringed orchids. This rare wildflower is expected to be in bloom in mid-July. Look for it, other prairie wildflowe... Learn more
Arctic Alpine Plants of the North Shore
Schroeder, MN
July 11, 2015
Cooler temperatures along Lake Superior's North Shore can create a microclimate ideal for plants that otherwise grow only in arctic or alpine settings. Hike this rocky shoreline near Temperance River State Park with Dr. John Pastor, a Professor of Biology at th... Learn more
Lake Alexander Open House
Lake Alexander Preserve
August 22, 2015
The 1,734-acre Lake Alexander Preserve, located just west of Crow Wing County and the Brainerd Lakes area, is part of a mosaic of wetlands, hardwood forests, and stands of red and white pines and is one of the Conservancy's great success stories in Minnesota. L... Learn more
Tallgrass Aspen Parkland Tour
Meet at the Conservancy office in Karlstad, Minnesota
August 29, 2015
Join us for an introduction to the Conservancy's Tallgrass Aspen Parkland project in one of Minnesota's most intact and spectacular grasslands. Elk will be in rut during your visit and you might hear (and possibly see) these great animals bugling. ... Learn more
Volunteer Opportunities
Join us!
Nature Conservancy volunteers offer us a way to increase our effectiveness, expand our range and complete more critically important work while developing lasting friendships and having a lot of fun. Learn more


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text: Summary Files ★ Add a Review 0 Downloads (This Week) Last Update: 2014-06-09 Description The Open Source Job Board JobberSource Web Site Categories Message Boards License MIT License KEEP ME UPDATED Get project updates, sponsored content from our select partners, and more. By clicking on "Follow" below, you are agreeing to the Terms of Use and the Privacy Policy. Invalid email address. Please try again. Sent to None. Follow You seem to have CSS turned off. Please don't fill out this field. You seem to have CSS turned off. Please don't fill out this field. Write a Review User Reviews Be the first to post a review of JobberSource! Additional Project Details Languages English Intended Audience System Administrators User Interface Plugins Programming Language PHP Registered 2008-09-17 This is a BerliOS project. Check out the BerliOS project page for more information. Report inappropriate content


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The Top 10 In Action Sports
01Brick By Brick: Camping Lego Style
02Booze and Bikes: 14 Tours That Let Combine Two of the Best Things in the World
03Who Needs Hollywood? These Incredible Videos Were All Filmed on the Simplest Cameras
04Sam Pilgrim vs. The World: The Champion Aiming To Reclaim His Crown In A New Era Of Biking
05Eccentric Adventures Episode 2: Britain's Most Brutal Illegal Event is All About Cheese
06A Journey Into Darkness: We Went Mountain Biking in the Abandoned Mines of Slovenia
07After the Apocalypse: Inside The World's Most Breathtaking Ghost Towns
08Debate: Let's Stop Hating On Parents Who Want To Raise Adventurous Kids
09Guns, Roses, And Eating Insects: Adventure Cycling in Vietnam
10From Intense Trails to Intensive Care: Dicing with Death In a Mountain Biking Paradise
100% Loic Bruni - Stepping up to the Pro ranks
A Mountain Biking video by Ride100Percent - 8,504 views
2012 World Junior DH Champion & Team Lapierre International rider Loic Bruni announces officially today that he's joining the 100% family. Stay in touch with Loic Bruni on Facebook, Twitter, Instagram. http://ride100percent.com/team/loic-bruni Filmmaker: Mathieu Echeverri - Genepi Film - genepifilm.com Music: Elodie Goulding - Lights / Dark Objekz Remix http://soundcloud.com/darkobjekz/ellie-goulding-lights-dark
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Douglas Albert Munro
Oct. 11, 1919
British Columbia, Canada
Sep. 27, 1942
World War II Medal of Honor Recipient. He served as a Petty Officer Signalman First Class and holds the distinction of being the only member of the US Coast Guard to receive the Medal of Honor. In 1939, he was attending the Central Washington College of Education when he left to enlist in the US Coast Guard. With the outbreak of World War II, he volunteered to be part of the US Coast Guard's ship transport fleet in the Pacific. In engagements at Guadalcanal Solomon Islands, on September 27, 1942, Petty Officer Munro was in charge of the original detachment of ten Higgins boats that had landed the Marines on the beach. After successfully landing the Marines, he noticed that they were under attack from a larger Japanese force and needed to be extracted immediately. Petty Officer Munro volunteered to lead the boats back to the beach for the evacuation. Commanding the rescue expedition, he brought the boats in-shore under heavy enemy fire and proceeded to evacuate the Marines still on the beach. Though the majority of the Marines had been loaded into the boats, the last remaining elements of the rear guard were having difficulty embarking. Assessing the situation, he maneuvered himself and his boats into a position to cover the last groups of men as they headed to the boats. In doing so, he exposed himself to greater enemy fire and suffered his fatal wound. It as reported that he had remained conscious long enough to utter his final four words: "Did they get off"? For his heroic and selfless actions in the completion of this rescue mission, he was posthumously awarded the Medal of Honor by President Roosevelt at the White House in May 1943.
(bio by:
John "J-Cat" Griffith)
Family links:
James Munro (1891 - 1962)
Munro (1895 - 1983)
Cause of death: Killed by enemy fire
Laurel Hill Memorial Park
Cle Elum
Kittitas County
Washington, USA
Plot: Veterans Memorial/Flagpole
Maintained by: Find A Grave
Record added: Oct 27, 1999
Find A Grave Memorial# 6770
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Tom Kermen
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E.J. Stephens
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Added: May. 25, 2015
I'm a Navy vet myself, Doug, so I know your story. When I hear someone 'dis' the Coasties, I tell 'em about you and what you did that day on the Canal. God bless you on this Memorial Day, Brother. Rest in His arms.
a shipmate
Added: May. 24, 2015
God bless you on Memorial Day (early). Rest in Peace.
Richard S. Barzelogna
Added: May. 24, 2015
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ROY ROGERS BEDROOM SET AND PAPER DOLLS. Very fine quality ...
Slater Provenance Auction #4 #1083
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|Jul 29, 2004
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2,527 page views
|Indianapolis, IN
Very fine quality and nice condition is this Roy Rogers cowboy bedroom set, including two pairs of curtains and a twin bedspread. The curtains and spread were originally sold in bolts of fabric to be made into the set. Any littlecowboy would have sweet dreams with this grouping to decorate his room. Along with this lot are two Roy Rogers and Dale Evans paper doll sets...maybe not for the boys but perhaps for the girls too. Both paper doll sets have been cut out and are probably not complete but appear here in nice condition with minimal wear. Very nice cowboy grouping !!
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Sesame Street
THERE'S AN APP FOR THATSeries Website »
Episode Guide »
Telly exchanges his old, beloved pogo stick for a brand new iPogo from Mack the pogo salesman.
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Vermont PBS Announces First Recipient of Public Media Ambassador Award


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Tuareg Rallye 2014 - OFFICIAL Event coverage thread - follow our ADV Inmates here!
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JMo (& piglet)
Gone a bit Baja
Joined: Apr 2007
Location: Somewhere west of Laramie...
Oddometer: 4,445
During the Star Wars day (stage 4) yesterday, the Torque Racing team set up camp in the desert (the four laps for the Moto Profi riders required refueling all day):
This year, Torque are sharing the Rallyservice.SE truck with 5 Swedish riders, including my highlighted rider Tony Landh, who had a storming day yesterday - finishing 4th on the stage and bumping him up to 6th in the overall standings after what he felt was a lack-lustre performance at the beginning of the rally... of course to the rest of us, he's been storming all week!
We also go the opportunity to properly test the LC4-50 in the sand yesterday... Martin Wittering (Torque Racing) was ably to tweak the fueling by lap top in the field:
While Calle (Hagenblad) also managed to blag a go on the LC4-50, and was genuinely impressed!
Now all we have to do is convince him to ride the sister bike in Dakar 2015!
Honda CB500X 'Adventure' - not a unicorn as such, just a little mule with a bump on it's head...
JMo (& piglet)
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We invite executives in growth-focused, middle market companies and capital providers to join us for our upcoming lunch in San Antonio:
Gary Dudley, Co-Founder & Pres. of SWBC
Date: Tuesday, June 30th, 11:30AM-1:30PM
Location: The Plaza Club in the Frost Bank Bldg.
@ 100 W. Houston St. Suite 2100
Sponsor: Bank SNB
For a complete list of upcoming events, click here
2015-04-28 Jim Class from Sara Singer on Vimeo.


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Director: Lee Davis Starring: Keshia Knight Pulliam Tom Bosley
Learn more about Christmas At Waters Edge:
Format: DVD
Manufacturer: Image
Sku: 204966132
Category Keywords: Angels Christmas Family (General) Relationships
See more in Action/Adventure
She Can Save the Day...with a Little Help from Above!
|For spoiled, wealthy college girl Layla Turner (Keshia Knight Pulliam, Beauty Shop, TV's The Cosby Show), Christmas usually means designer wrapping paper and holiday gift bags from Bloomingdale's. But this year, Layla will learn the true meaning of the season when an unlikely angel in disguise (Pooch Hall, Hood of Horror, TV's The Game) arrives with a very special mission: to turn this pampered brat into a caring young woman! Don't miss this unforgettable modern-day Christmas Carol - a coming-of-age story full of heart and soul. Also stars Emmy nominee Tom Bosley (TV's Happy Days, Murder, She Wrote), Earl Billings (Thank You for Smoking, Antwone Fisher) and Richard Lawson (Guess Who, How Stella Got Her Groove Back).
Editor's NoteA spoiled rich girl (Keshia Knight Pulliam, THE COSBY SHOW) learns the true meaning of Christmas from a disguised angel (Pooch Hall) in this heartwarming, latter-day Scrooge tale.
Cast & Crew
|Earl Billings
|Keshia Knight Pulliam
|Pooch Hall
|Richard Lawson
|Cleveland O'Neal, III - Executive Producer
|Lee Davis - Director
|Riley Weston, et. al. - Writer


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Originally written on Football Nation | Last updated 11/5/13
Concussions have become a hotly debated topic in the last several years, specifically when it comes to the NFL and its management of the players in the past. It has led to rule changes that have tried to protect players both on and off the field, to documentaries (League of Denial) and in a forgotten way, the loss of a player's job.With the way the San Francisco 49ers and Kansas City Chiefs have played this year, November 11, 2012 is a fairly significant date. The path both franchises have taken since then has been a lost storyline with both teams emerging as Super Bowl contenders this season. Unfortunately, during the ninth game of 2012 for the 49ers, a concussion changed the careers of two quarterbacks, and two franchises as well. With 1:10 left in the first quarter, starting quarterback Alex Smith suffered a concussion as he slid to avoid a hit from St. Louis Ram linebacker Jo-Lonn Dunbar. However, Smith turned his back late and was hit by Dunbar around the neck area. Smith would...
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Phil Clarke defends his Challenge Cup stance where he says mismatches do more harm than good
Phil Clarke defends his Challenge Cup stance where he says mismatches do more harm than good.
Last Updated: 07/05/14 3:24pm
Read Phil's views of the state of the Challenge Cup here
Their Chairman, Neil Hampshire, wrote to say that the fixture would prove to be a cash windfall for the club and that I was disrespecting the 100 year history of the competition.
Some said that I was in danger of denying rugby league a chance to see the David versus Goliath sporting contests which are so popular all over the world.
There was an interesting comment by one man who felt that change was needed and that Super League clubs should be forced to play without their overseas players to make the contest a more even one.
Let me say that I am not a fan of change in sport. I like tradition, and it is sometimes embarrassing how often we change things in rugby league.
However, I have thought about the future of the Challenge Cup for some years now and the direction it should take. It is a special day in the rugby league calendar and I want to see it grow and prosper.
But the opening 20 minutes of the game played between Wigan and Hunslet proved my point that the part-time players are not able to cope with the speed and strength of the full time professionals. The Warriors scored seven tries in the first 13 sets of possession.
The draw for the quarter-finals could have pitched Leigh against Keighley which would obviously have put one of them into the semi-final. Much as I admire both clubs and wish them well, I do not think that the game would have benefitted from one of them trying to take on say Leeds say in a semi-final.
I think that this type of contest and exposure may have been detrimental to the game, much as it might have helped in the short term with cash flow at the two smaller clubs.
A Cup for all?
I think that we have reached a stage when the divide in the sport means that we need to have a separate cup or cups. I appreciate that this idea needs some consultation but I would like to suggest that we have a Challenge Cup Finals day/weekend at Wembley in the future.
I think that we need to offer the smaller clubs a real chance to play at Wembley by organising a knock-out cup that gives each level of the game a chance to make it to the big stage.
How about a final for the best two teams from the Community Game, one for the best two part-time teams and one for the Top 16 Teams in the country? The greatest thing about the Challenge Cup is that it brings the whole game together, let's do that even more.
I made contact with the Chairman of Hunslet this week and debated the subject at length. I listened to his experiences of the game against Wigan and the path that the club is on these days.
I wish them well as they seem to be developing a club on some sound business principles and I hope that they continue to contribute to the game, rather than take from it as some part-time clubs have done in the past.
However, he also accepted some of the points that I made and felt that the chance for Hunslet to go to Wembley and play there again would be a very exciting and uplifting for the club.
We have had and still do have finals days in rugby league when more than two teams provide the entertainment. The concept of double-headers seems successful in rugby union.
Can someone out there please work out a way of making it work for the Challenge Cup?


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And those have been disgracefully few and far between, for way too long now.
On December 12, 2014, the National Labor Relations Board (NLRB) announced its adoption of a final rule to modernize and streamline the process for resolving union representation disputes. The long overdue rule, taking effect on April 14, 2015, will reduce a number of obstacles working people face when trying to form a union to better their workplaces. (Click on the link) to learn more about these obstacles and why this commonsense NLRB union election rule was needed to help ensure a fair vote in the workplace.
When workers want to vote on whether to form a union, they should have a fair chance to do so. However in recent decades, when employees decided to hold an election on whether to form a union, they could typically encounter significant uncertainty and obstacles that make the process unfair. After workers petition the NLRB for an election, it could take months and even years before they get to cast a vote. Such delays cause unnecessary conflict and disruption in the workplace.
Modernizing the NLRB election process for forming a union creates a level playing field. Employers and workers alike are entitled to a process that cannot be manipulated to gain unfair advantage and is clear, precise, and efficient. Workers will now a fair chance to vote their preference.
(Jobs With Justice)
This is really good, but the way the deck is stacked against organized labor right now, in so many ways, it's just a fraction of what's needed. Anything that helps unions needs to be fought for, but so do legislative efforts, at all levels, just generally on behalf of the non-rich. A lot of efforts. Traditional labor unions are not likely to again be what they were decades ago – the basis of the middle class – any time soon. Quite possibly never.
Also, just being realistic:
The National Association of Manufacturers and the National Retail Federation are considering lawsuits to prevent the NLRB's rule from taking effect. Given the anti-worker tilt to many courts, they have a decent shot, just as business groups were able to block a previous NLRB rule calling for employers to put up a poster explaining workers' rights under federal law.
(Daily Kos)
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579 Rentals · Mumbai
579 Rentals · Mumbai
Extremely Desirable location. Free Wifi. Elegantly furnished spotlessly clean apartment with air conditioning for single person or couple - with living room, bath, kitchen, 5 minutes walk to the sea. Plenty of restaurants and cafes in the vicinity. Learn More
You have everything you need in one cozy apartment - bathroom, kitchen, living room, bedroom - plus privacy. The apartment is furnished with some antiques as well. The place is clean and well maintained with air conditioning. Free Wifi Will provide you will contact numbers and glad to answer any of your questions to help your trip. Bandra is really the ideal suburb to live with easy access to airport and train stations as well as shopping centers, cafes, restaurants, banks and ATMs and...
5 mins to the airport and the railway station, yet lapped in nature, with parakeets flying in the park you overlook. We've lived in Mumbai for 55 years, and our son studies abroad, leaving us time to share our experience of the city and its sights. Learn More
Homely atmosphere. Guests will have access to the kitchen if they so desire. We are very happy to interact with our guests. Peaceful & Green. Trains, taxis, auto rickshaws, buses all easily available. parking is included with my listing. Guest can take prepaid taxis from airports to get to our home. Subway & Dominoes Pizza on the parallel road.
This is a fully furnished one bedroom apartment, with a lovely separate living space, a large bathroom and a fully equipped kitchen. We have done our best to make it comfortable and cozy. Its in the perfect location, in a suburb called Bandra. Learn More
Wake up, walk into Bombay's iconic Juhu beach (2mins), or hop into a rick, catch a play at Prithvi theatre (10mins), or roll into the culture/hipster capital of Bandra (15mins). Our spacious, roomy & airy 1BHK is a traveller's haven. Learn More
Its one room with a kitchen and washroom..The studio apartment is in the ground floor of a quite locality..market,ATM nearby...Its near to international airport..will provide breakfast ...has good WiFi speed of 4 Mbps..if you want you are welcome to cook your meals:) Learn More
The studio apartment is in a residential area..with parking space..I stay here and 2 more people can share the room with me as I have 2 comfortable beds available..you are welcome to cook your meals..will provide breakfast..which is usually continental breakfast.. You have access to WiFi, washing machine,fridge ,utensils and can cook your own food by bringing the necessary things required I am a working person..but will try to give you as much time as I can when I have offs..However if yo...
You will have a beautiful large room all to yourself, with WiFi, plenty of closet space and all the amenities you require of a well done home. Incredible city access, just 5min away from the Sea Link bridge that connects North and South Mumbai! Learn More
I'm happy to host you at my home in Mumbai. It's a lovely home, well located in the heart of Bandra West (the best area, bar none, to live in Mumbai if you ask me!). You have everything at my home - WiFi at 25 Mbps speed, Air Conditioning, Washing Machine, enormous closet space etc. There's nothing I don't have and everything is high-end equipment and immaculately maintained. You have access to the entire home. You have your own bathroom too. There is a maid that comes almost daily to clea...
Available 1bhk fully furnished flat to stay above 10-90 days near Juhu Beach, Landmark J W Marriott Hotel in 2nd Floor without lift. Learn More
A Savvy and beautiful apartment in South Mumbai. Sea Facing View. Private Bedroom with a Real Bed and Private Bathroom. Learn More
This spacious 3 bedroom 3 bed is ion a tree lined cul de sac and has open views. Location is in central Bandra - Close to Pali Hill, Carter Road, And dozens of restaurants, Bars and clubs. Can be rented by room or entire apartment Learn More
Cosy 1BHK flat in Central Mumbai in a posh locality Dosti Acres with club house facility of swimming pool, and other sports. Lighted and airy room. Clean and hygienic place to have a comfortable stay. Tasty and delicious Indian vegetarian breakfast. Learn More
A 1bhk flat, lighted and airy, hygienic space with wi-fi, water purifier, gyser equipped bathroom, etc. A very good sports club with swimming pool, pool table, billiards, carrom, table tenniss, chess, etc. Will have access to a separate room, a almirah with safe and key for themselves. Will have access to wi-fi, tv, swimming pool, billiards, table tennis, etc. No timing restrictions. Early morning body massage at extra cost. I like interacting with new people. I am available on weekends f...
Room with a Sea view and attached bath in Mumbai, Warden road. Access to use of hall and kitchen. Wi-Fi, Washing machine and ironing facilities in house. No AC Cat in apartment. Call +919820068695, +912240036618, +912223670748 Learn More
Located in very posh and classy Versova area in Mumbai, with many tv celebs around. In Andheri west, 20 mins from Airport, magnificent sea view from bed. TV with cable, AC, unlimited & fast wifi, private bathroom with geyser attached with the room. Learn More
i like peace and homely atmosphere i expect you to live here as if you are staying in your own room and i would love to welcome you Learn More
Located in the heart of mumbai's uptown western suburbs. Great access to all shopping, restaurants, pubs, bars and night life. Peaceful and quite surroundings. Comfortable stay with access to kitchen,hall and 2 bathrooms. Perfect for a quick trip. Learn More
living room, bathhroom, kitchen available for any help
A private and comfortable bedroom with attached bathroom Learn More
A neat, well equipped 'room for two'(10th floor) in an authentic, quaint corner of the city, our apartment overlooks a small garden. Home to parrots,kites, and beautiful views, the bus/ train stations,amazing cafes and restaurants are just 5min away! Learn More
<b>About the property</b> This penthouse apartment is inCentral Mumbai, India.I am a french teacher and I work with an International school( but I;m proudly Indian!) The apartment has 2 bedrooms, with one room for rent. I generally take only one person to stay with me at anytime, but couples are also welcome. Your room has a private bath. The terrace over looks a beautiful garden.The ap artment has an elevator and theapartment is the only one on the floor. Its situated ideally in a qu...
Over View A nice cozy safe Private Room for a great stay in Mumbai, India SAFE & Clean Environment 10 minutes drive from International Airport Very close to Powai Lake Centrally located with public & private transport facility Internet & WI-FI Learn More
Private Room. Attached (Ensuite) bathroom with hot water & shower facility. It comfortably fits two adults. Enjoy a perfect home-stay accommodation with an Indian family to experience Indian customs, traditions, with the added value of total privacy. AirCon available (Charged Separately). Internet & WI-FI Kitchen. Common hall with TV Tea / Coffee will be provided. Guests are welcome to use our kitchen, fridge and prepare light snacks. Use our cutlery and crockery but we do expect them to...
Mumbai Holiday Apartment is an ideal alternative to hotels; our luxury self catering apartment provides more space and amenities for your budget than a good hotel. Its family oriented apartment with central location. Learn More
Mumbai Holiday Apartment is an ideal alternative to hotels; our luxury self catering apartment provides more space and amenities for your budget than a good hotel. When you choose to stay at Mumbai Holiday Apartment, you get so much more than just a room - you get a home like feeling, quality services, privacy, and an experience where memories you take with you will last a lifetime. Please request for our guest reviews. It is a family orientated building with a lovely atmosphere on a priva...
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Grads on their way
June 3, 2015 Only 18 St. John Neumann Regional Academy students draped in maroon and gold robes took to the stage at Penn College's Klump Academic Center to receive their diplomas Tuesday night. more »»
Experts describe crime-scene evidence
June 3, 2015 Law enforcement, a forensic pathologist and a forensic anthropologist testified Tuesday in an effort to unearth the truth in a 2013 Jersey Shore homicide. more »»
JS man gets 10-20 years in child sex assault case
June 3, 2015 LOCK HAVEN — A 20-year-old Jersey Shore man will spend at least the next decade behind bars for the sexual assault of 4-year-old in Woodward Township several years ago. more »»
House digs into Senate GOP pension bill
June 3, 2015 HARRISBURG — A key Pennsylvania state Republican House lawmaker signaled support Tuesday for major provisions in a Senate Republican plan to end the traditional pension benefit for school and state... more »»
County OKs grant application for drug treatment
June 3, 2015 Lycoming County commissioners Tuesday approved an application for $300,000 of state money that would go toward a pilot program to treat drug abuse in individuals leaving the county prison. more »»
Wolf seeks state authority over health insurance marketplace
June 3, 2015 HARRISBURG (AP) — Go. more »»
FBI behind mysterious planes over cities
June 3, 2015 WASHINGTON — Scores of low-flying planes circling American cities are part of a civilian air force operated by the FBI and obscured behind fictitious companies, The Associated Press has learned. more »»
Retirement costs on school board agenda
June 3, 2015 The Williamsport Area School Board is preparing for the future with transfers, designations and construction changes. more »»
Fire damages Wyoming Street home
June 3, 2015 After kicking in the front door to reach a kitchen fire about 1:30 p.m. more »»
16-year-old hurt in Wolf Township crash
June 3, 2015 PENNSDALE — A 16-year-old Muncy girl suffered moderate injuries when she lost control of her Volkswagen Jetta, which crashed on Rabbittown Road in Wolf Township about 7:40 a.m. more »»
Basketball coach returns to Hughesville; new PE teacher also approved
June 3, 2015 HUGHESVILLE — East Lycoming School District school board voted in approval of some personnel changes, including a new physical education teacher and a new head boys basketball coach at the school... more »»
Vehicle break-ins on the rise in city
June 3, 2015 The city public safety committee was alerted Tuesday to a rash of vehicle break-ins and vandalism occurring throughout the city of late. Police Chief Gregory A. more »»
Rezoning of Newtown Hill Road unlikely
June 3, 2015 MANSFIELD — A proposed rezoning of portions of Newtown Hill Road into a special business overlay zone, discussed at the May Richmond Township supervisor's meeting, is not likely to happen, for... more »»
Council to review draft of burning ordinance
June 3, 2015 MUNCY — A borough burning ordinance came one step closer to reality Monday night after borough solicitor Christopher Kenyon handed out a draft of the proposed ordinance for council members to revie. more »»
Montoursville OKs hiring of part-time summer help
June 3, 2015 Montoursville Borough Council approved Daniel Yeagle as a part-time seasonal park employee at a rate of $10 per hour by a 6-0 vote Monday night during its meetin. more »»
City planners recommend residential subdivision plan
June 3, 2015 The city planning commission on Monday gave a positive recommendation to a developer's subdivision plans to construct two, single-family houses on a vacant lot at 1101 Meade St. more »»
South Side board changes next meeting
June 3, 2015 South Williamsport Area School Board's next meeting will be held at 7 p.m. June 22. It originally was scheduled for June 15, but Dr. Mark Stamm, superintendent, wanted to give Gov. more »»
Testimony begins
June 2, 2015 Trial proceedings began Monday for a Jersey Shore man accused of killing and burying another man in his basement. more »»
Hit-and-miss showers may affect some graduations
June 2, 2015 Looking ahead to outdoor high school graduations this week, attendees should keep an umbrella handy. more »»
Paramedics recognized
June 2, 2015 Mayor John Dorin and the Montoursville Borough Council recognized paramedics and emergency medical technicians for their service to the community at council's regular meeting Monday nigh. more »»


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German Police Arrest 'Salafist' Couple Suspected of Planning Attack: Report
World News | Agence France-Presse | Thursday April 30, 2015
German police have arrested a married couple suspected of having planned an attack and have seized an assault rifle, ammunition and a pipe bomb in their home, Die Welt daily reported Thursday.
Jordan Takes Islamic State Battle to Internet, Mosques
World News | Agence France-Presse | Friday November 14, 2014
Jordan is cracking down on firebrand preachers and online extremism to tackle jihadists after joining US-led air strikes on the Islamic State group.
Egypt's Abdel Fattah al-Sisi, a Tough-Talker But With Smiles
World News | Agence France-Presse | Wednesday May 21, 2014
Egypt's presidential frontrunner Abdel Fattah al-Sisi has a polished new civilian image after ousting elected leader Mohamed Morsi, but his tough talking has raised fears of a return to autocracy.
Brother of al-Qaeda chief Ayman al-Zawahiri arrested in Egypt
World News | Associated Press | Saturday August 17, 2013
Mohammed al-Zawahiri, leader of the ultraconservative Jihadi Salafist group, was detained at a checkpoint in Giza, the city across the Nile from Cairo.
ElBaradei sworn in as Egypt Vice President
World News | Press Trust of India | Sunday July 14, 2013
Prominent liberal leader Mohammed ElBaradei was sworn in today as Egypt's interim vice president for foreign relations, even as Prime Minister Hazem al-Beblawy continued negotiations to form the new Cabinet following the ouster of President Mohamed M...
Al Qaeda planning attack on US consulate: Thailand
World News | Press Trust of India | Tuesday February 12, 2013
Thailand has beefed up security at the US consulate in the northern province city of Chiang Mai after receiving information that al Qaeda and Salafist terrorists were planning to launch a three-pronged attack on it this month.
Tunisian Salafist leader escapes arrest for film protest
World News | Reuters | Monday September 17, 2012
A Tunisian Salafist leader on Monday escaped from a mosque that had been surrounded by security forces seeking to arrest him over clashes at the U.S. Embassy last week during protests against an anti-Islam film, a Reuters witness said.


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Evaluation of patients with metastatic renal cell carcinoma after failure of first-line treatment
ABSTRACT The approval and use of molecular targeted agents for the first-line treatment of metastatic renal cell carcinoma (mRCC) has substantially improved the clinical outcome of patients. Although eventually all patients progress, hopes have been renewed with the approval of everolimus for patients who progress on or after treatment with tyrosine kinase inhibitors. In order to improve the prognosis for these patients, it is imperative to understand the reasons why patients with mRCC fail on first-line treatment. Currently, progression is assessed on the basis of the Response Evaluation Criteria in Solid Tumors, but it is known that targeted agents tend to cause disease stabilization rather than a significant decrease in tumor mass. Therefore, it may be time to evaluate the need to incorporate additional diagnostic methods in the assessment of disease response. Equally important is the study of the factors that determine the success or failure of second-line therapy in order to increase the chances of delivering the most effective and personalized therapy possible. In this article, we review the evidence related to the evaluation of patients with mRCC who fail on first-line treatment with targeted agents, including the systems to assess response and progression, the prognostic factors, the prognostic models that have been created based on these factors, and what is known about predictive biomarkers of disease outcome.
Article: Radiogenomics of Clear Cell Renal Cell Carcinoma: Associations between CT Imaging Features and Mutations[Show abstract] [Hide abstract]
ABSTRACT: Purpose:To investigate associations between computed tomographic (CT) features of clear cell renal cell carcinoma (RCC) and mutations in VHL, PBRM1, SETD2, KDM5C, or BAP1 genes.Materials and Methods:The institutional review board approved this retrospective, hypothesis-generating study of 233 patients with clear cell RCC and waived the informed consent requirement. The study was HIPAA compliant. Three radiologists independently reviewed pretreatment CT images of all clear cell RCCs without knowledge of their genomic profile. One radiologist measured largest diameter and enhancement parameters of each clear cell RCC. Associations between CT features and mutations in VHL, PBRM1, SETD2, KDM5C, and BAP1 genes were tested by using the Fisher exact test. Associations between mutations and size and enhancement were assessed by using the independent t test. Interreader agreement was calculated by using the Fleiss κ.Results:Mutation frequencies among clear cell RCCs were as follows: VHL, 53.2% (124 of 233); PBRM1, 28.8% (67 of 233); SETD2, 7.3% (17 of 233); KDM5C, 6.9% (16 of 233); and BAP1, 6.0% (14 of 233). Mutations of VHL were significantly associated with well-defined tumor margins (P = .013), nodular tumor enhancement (P = .021), and gross appearance of intratumoral vascularity (P = .018). Mutations of KDM5C and BAP1 were significantly associated with evidence of renal vein invasion (P = .022 and .046, respectively). The genotype of solid clear cell RCC differed significantly from the genotype of multicystic clear cell RCC. While mutations of SETD2, KDM5C, and BAP1 were absent in multicystic clear cell RCC, mutations of VHL (P = .016) and PBRM1 (P = .017) were significantly more common among solid clear cell RCC. Interreader agreement for CT feature assessments ranged from substantial to excellent (κ = 0.791-0.912).Conclusion:This preliminary radiogenomics analysis of clear cell RCC revealed associations between CT features and underlying mutations that warrant further investigation and validation.©RSNA, 2013Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.13130663/-/DC1.Radiology 09/2013; 270(2). DOI:10.1148/radiol.13130663 · 6.21 Impact Factor