text: Wild about Wildlife School Days ADD TO Trip Planner Teachers, sign up your students for a wild time in the great outdoors and enjoy a day filled with fun educational programs dealing with the wildlife found on Crowley's Ridge. Registration is required at least two weeks in advance. Get Directions Gas Calculator Details Dates: Tuesday, May 07, 2013 Hours: 9:30 a.m. - 12:00 p.m. Venue: CCC Pavilion Address: Paragould, AR 72450 Admission: $1 Phone: 870-573-6751 Contact: Park Superintendent Email: firstname.lastname@example.com


text:
Geometric and Statistic Constraints in Dynamic Re-Orientation of On-Board Camera: Inherent Vanishing Points
ABSTRACT This paper investigates the stochastic projective properties of natural line segments in highway scenes for the purpose of dynamically re-orientating the on-board camera. We demonstrate there are geometric and statistic constraints on the projection of such line segments. A new concept of Inherent Vanishing Points associated with land vehicle boards was employed to relate to the observed line segments and rotation matrix. We show how these constraints greatly simplify the re-orientation of the on-board camera. We validate a dynamic re-orientation algorithm based on these constraints with a real image sequence. Compared with the techniques based on static calibration fields, the method based on our proposed statistical constraints is effective, stable, and easy to use.
- References (20)
- Cited In (0)
- SourceAvailable from: Ling Wang[Show abstract] [Hide abstract]
ABSTRACT: A novel approach to camera calibration by vanishing lines is proposed. Calibrated parameters include the orientation, position, and focal length of a camera. A hexagon is used as the calibration target to generate a vanishing line of the ground plane from its projected image. It is shown that the vanishing line includes useful geometric hints about the camera orientation parameters and the focal length, from which the orientation parameters can be solved easily and analytically. And the camera position parameters can be calibrated by the use of related geometric projective relationships. The simplicity of the target eliminates the complexity of the environment setup and simplifies the feature extraction in relevant image processing. The calibration formulas are also simple to compute. Experimental results show the feasibility of the proposed approachIEEE Transactions on Pattern Analysis and Machine Intelligence 05/1991; 13(4):370-376. DOI:10.1109/34.88572 · 5.69 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: We propose a method to locate three vanishing points on an image, corresponding to three orthogonal directions of the scene. This method is based on two cascaded Hough transforms. We show that, even in the case of synthetic images of high quality, a naive approach may fail, essentially because of the errors due to the limitation of the image size. We take into account these errors as well as errors due to detection inaccuracy of the image segments, and provide a method efficient, even in the case of real complex scenesIEEE Transactions on Pattern Analysis and Machine Intelligence 05/1994; DOI:10.1109/34.277598 · 5.69 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: This paper presents a new method for the detection of vanishing points based on sub-pixel line descriptions which recognizes the existence of errors in feature detection and which does not rely on supervision or the arbitrary specification of thresholds. Image processing and image analysis are integrated into a coherent scheme which extracts straight line structure from images, develops a measure of line quality for each line, estimates the number of vanishing points and their approximate orientations, and then computes optimal vanishing point estimates through combined clustering and numerical optimization. Both qualitative and quantitative evaluation of the algorithms performance is included in the presentationIEEE Transactions on Pattern Analysis and Machine Intelligence 12/1995; DOI:10.1109/34.473236 · 5.69 Impact Factor

subset: commoncrawl


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'Binders full of women': a revealing remark from Romney, or a sideshow?(Read article summary)
'Binders full of women' is already the most memorable phrase of the second presidential debate, showing just how much the 2012 campaign revolves around issues narrowly targeted to specific groups ŌĆō a strategy of the Obama campaign.
Rick Wilking/Reuters
With all the challenges facing our nation ŌĆō from the millions of Americans still unemployed to terrorist threats abroad ŌĆō is the presidential election really coming down to a fight over Planned Parenthood and Mitt RomneyŌĆÖs ŌĆ£binders full of womenŌĆØ?
That last phrase, of course, was the unfortunate choice of words Mr. Romney used in Tuesday nightŌĆÖs debate in explaining how, as a governor, he had made an explicit effort to appoint women to his Massachusetts cabinet.┬ĀUpon discovering that most applicants for the posts were men, Romney said he asked his staff: ŌĆ£Well, gosh, can't we ŌĆō can't we find some ŌĆō some women that are also qualified?" He went on: "And ŌĆō and so we ŌĆō we took a concerted effort to go out and find women who had backgrounds that could be qualified to become members of our cabinet. I went to a number of women's groups and said: ŌĆśCan you help us find folks?ŌĆÖ and they brought us whole binders full of women.ŌĆØ┬Ā
LetŌĆÖs put aside the fact that the accuracy of RomneyŌĆÖs remarks has already come into question. (The Massachusetts WomenŌĆÖs Political Caucus reportedly prepared the ŌĆ£binderŌĆØ in question well before the election, and had presented it to both Romney and his opponent.) Or that the substance of his response was, in essence, a dodge of the question posed, which had been about equal pay for women.
The larger point is, in a feisty and serious debate that ranged from energy policy to tax policy to the attack in Libya, itŌĆÖs telling that the most memorable phrase to emerge from the whole evening was ŌĆ£binders full of women.ŌĆØ It was, as many commentators have pointed out, this debateŌĆÖs Big Bird.
Apparently, thatŌĆÖs just how the Obama team wants it. With an economic record thatŌĆÖs still far short of where he hoped it would be ŌĆō and with critics accusing the president of failing to offer a concrete, overarching vision for the next four years ŌĆō Obama has run a campaign that often seems to focus instead on narrower appeals to specific segments of the electorate, just as George W. Bush did in 2004.
Which is why, throughout this election cycle, weŌĆÖve heard so much about the Lilly Ledbetter Fair Pay Act and whether insurers should have to cover contraception. And why the Democrats gave former Georgetown Law student (and Rush Limbaugh b├¬te noire) Sandra Fluke a prime speaking slot at their convention. And why swing states are currently being pummeled with ads by the likes of Scarlett Johansson and Eva Longoria, talking about how Romney wants to overturn Roe v. Wade.
This is not to say that these issues arenŌĆÖt important ŌĆō or that women (and men) shouldnŌĆÖt take them into account when they head into the voting booth. Certainly, women, like all voters, want a president who shares their values ŌĆō including their views on gender and equality ŌĆō and for many, RomneyŌĆÖs remarks may have presented an important window into his character.
But it still feels, for lack of a better word, like a bit of a sideshow. A distraction from the main event.
Of course, the Romney campaign has at times played the same game ŌĆō remember the ridiculous brouhaha over lobbyist Hilary RosenŌĆÖs comment about Ann Romney never having worked a day in her life? Or Mrs. RomneyŌĆÖs heavy-handed ŌĆ£I love you, women!ŌĆØ shout-out at the Republican National Convention?
The pandering on both sides reflects just how crucial women voters will be to this election.┬ĀIndependent women are seen as a critical swing voting bloc, and they make up many of the ŌĆ£undecidedŌĆØ voters still remaining out there.┬ĀIn 2008, Obama won women by 13 percentage points, and he has maintained a double-digit lead among women voters throughout much of this campaign. But a recent much-publicized Gallup Poll (which the Obama campaign called an outlier) showed Romney tied with Obama among women. Other recent polls have shown Obama still ahead, but by less than his 2008 margin. ┬Ā
ThereŌĆÖs no question Romney helped Obama out Tuesday night with his awkward choice of words. Immediately after he uttered the phrase, Twitter was flooded with quips, most of which were along the lines of ŌĆ£IŌĆÖve seen those binders (heh, heh).ŌĆØ It was all made even funnier by RomneyŌĆÖs squeaky-clean, 1950s technocrat image (he loves those three-ring binders!).┬ĀWithin minutes, ŌĆ£binders full of womenŌĆØ had inspired a mocking Facebook page and Tumblr filled with joking pictures of women and binders (sample caption: ŌĆ£Trap Her Keep Her!ŌĆØ). ┬Ā┬Ā
But given the urgent challenges the country is facing right now ŌĆō including the looming "fiscal cliff," which economists warn could lead to another recession if Washington fails to act, and which has nevertheless not come up in any presidential or vice-presidential debate ŌĆō well, it all seems oddly off-point.┬ĀThe recent Gallup poll showed the top issues for women right now are health care and the deficit and national debt. In the final days of the presidential campaign, maybe thatŌĆÖs what we should be talking about.


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Norfolk State Spartans School SuppliesSavor the adrenaline of gameday with officially licensed Norfolk State Spartans School Supplies from the ultimate sports store! Sport your NSU devotion with quality Norfolk State University School Supplies featuring Spartans Pencils, Backpacks, Folders, Lunch Box, Notebook and Book Covers. Norfolk State fans, students and alumni, score your new Norfolk State Spartans School Supplies from our Norfolk State University Shop and receive your new Spartans Gear to the next game. Go Spartans!
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The Road Rash titles on the Genesis remain some of my favorite "line-scrolling" racing games of all time. The controls were tight, the combat was fun, the music was catchy, and the track design gave a great three dimensional feel. From the rolling hills to the tight turns, the Genesis games gave a realistic sense of screaming down the highway that few racers of the era could match.
Atari Jaguar. These two words seem to muster up so much controversy amongst the mainstream gaming press. "The controller is horrible" they say, "it's not really 64-bit." "Doom doesn't have music." For those that own a Jag, most of that disdain is misguided. With that in mind, I present to you the Top 5 Atari Jaguar games.
The American version of Super Mario Bros. 2 was released in 1988. The game was a critical and commercial success, becoming one of the best selling games on the original NES system. It was also released in 1993 for the Super Nintendo, as part of the All-Stars game pak. Of course as kids, we didn't know this was a reworking of the Japanese title Doki Doki Panic, but that's a story for another time.
WWF WrestleMania: The Arcade Game is a fighting game from Midway released in arcades in 1995, with home ports following the very same year.
The game takes the fighting elements from the Mortal Kombat series of games, mixes in some wrestling staples, and adds an NBA Jam style presentation over top, to create a unique fighting game experience.
While Electronic Arts was busy building Road Rash from the ground up for the 3DO, and later the Sega Saturn and Sony PlayStation, they also released an often overlooked title for the Sega CD. This one released in 1995, and unlike its 32-bit counterparts, uses the old Genesis engine, rather than something new.
As I've said in the past, the 16-bit generation of shmups was my favorite. The shooters of this era featured the perfect blend of speed and complexity, without feeling overwhelming. The genre really started hitting its stride and there are dozens of classic titles to choose from. On today's episode of 5 Games we are going to take a look at 5 more, great shmups released on 4th generation home consoles.


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"NOPE, party of one? Your table is ready."
[via Radass]
Tickets on sale NOW
After this coat, we just need to upgrade his AC unit and he'll be good as new.
So I guess Hand, Foot, and Mouth Disease is now a legitimate STD.
Sorry nice guys, the Friend Zone has no exits.
"NOPE, party of one? Your table is ready."
[via Radass]
Guys. I'm on vacation this week and all I want to do is lay by the pool while someone brings me drinks and treats. So in honor of these feels, I bring you ten people that are actually lazier than me. That's all I can find. I'm a mess.
Click through and then send it to your mom to remind her that you ARE productive and she's lucky to have you. Show full post
I can't believe it's taken me this long to realize how much dicks look like Darth Vader.
[via Imgur]
This guy is sleeping right through one of my best fantasies.
[via TC Mag]
This psychiatrist's office is designed for maximum relaxation.
[via Bro My God]


text:
water treatment plants Companies in Illinois
Global Environmental Solutions Ltd. (GES)
based in ISRAEL, ISRAEL
GES is an international leader in the design and construction of Sea Water Desalination and industrial and municipal Water and Wastewater Treatment plants and facilities worldwide. With vast experience of over 30 years GES provides full scope of process engineering, construction and operation services to municipal and industrial customers around the world.
based in Calgary, ALBERTA (CANADA)
Turnkey solutions: Custom designed engineering, Easily deployable skid-mounted, Easily operated and maintained, Modular and expandable systems, Stainless steel construction, Guaranteed performance. Industries Served: Drilling and Construction, Resorts and Hotel, New Subdivision, Small Municipalities, Hospitals, Food and Beverage, Metal Finishing.
KDF Fluid Treatment, Inc.
based in Three Rivers, MICHIGAN (USA)
KDF Fluid Treatment, Inc. is a technological leader in the fluid treatment industry. KDF process media are high-purity copper-zinc formulations used in pretreatment, primary treatment, and wastewater applications. KDF media supplement or replace existing technologies to dramatically extend system life, reduce heavy metals, microorganisms, scale, lower total cost, and ...
Waste Treatment Technologies B.V.
based in Almelo, NETHERLANDS
Waste Treatment Technologies (WTT) is a renowned and experienced supplier of high-tech waste treatment solutions. Founded in 1996, we've been designing, constructing, building and maintaining facilities all over the world. With offices in the Netherlands, Germany and Spain, we are able to offer our clients – a significant group of well-known international waste management ...
Aquaflow Ltd. - a Veolia Water Company
based in Savonlinna, FINLAND
Water, effluent and sludge dewatering equipment, plants and services for the pulp and paper industry. Aquaflow is specializing in water, effluent and sludge treatment in the pulp and paper industry. Whether you are a producer of chemical or mechanical pulp or a user of recycled fiber or producer of different paper grades, you can rely on our wide experience to create ...
Chesapeake Water Environment Association
based in Hunt Valley, MARYLAND (USA)
The Chesapeake Water Environment Association is dedicated to improving water quality and protecting the water environment in Delaware, Maryland, and the District of Columbia. The Association strives to do this through public education, the exchange of technical and scientific information among water quality professionals, the training of wastewater and water treatment ...
McNeill Water & Wastewater Inc
based in Tallahassee, FLORIDA (USA)
For over 40 years McNeill Water & Wastewater, Inc., has successfully delivered over 600 turnkey wastewater treatment solutions to government and private owners. In the mid-1980`s we developed our unique Design/Build approach which starts with McNeill Water & Wastewater, Inc., performing a preliminary evaluation and feasibility study, at no cost to the owner.
Clarity Water Products
based in VISTA, CALIFORNIA (USA)
Chemical-free water treatment for cooling towers, boilers and general use. Solutions for scale, biofilm and sanitation with less work, fewer problems, and little or no chemical use. Regulatory compliance is much easier. Blowdown waste is reduced and you start saving money. Surprisingly low cost in many cases! Manage your own system with ease! Chemical free is all we do, ...
Kurita Water Industries Ltd.
based in Tokyo, JAPAN
KURITA WATER INDUSTRIES LTD. provides water treatment systems for the semiconductor industry. For producing semiconductors, you need water as close as possible to theoretically pure H2O. When making pharmaceuticals, even a minute amount of bacteria contamination cannot be tolerated. Seawater desalination plants contribute to the all-important search for sustainable water ...
Aquaco Water Recycling Limited
based in East Peckham, UNITED KINGDOM
Aquaco designs and supplies grey water recycling and rainwater harvesting systems for residential homes, multi-residential, commercial and institutional applications.Aquaco also offers waste water treatment equipment for industrial applications.


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Articles tagged michael powell
29 Jan 2009 // 8:59 PM
'Age of Consent' is a rather unfortunate swan song, but 'A Matter of Life and Death' makes this DVD set well worth it.READ more
6 Jan 2009 // 3:43 AM
At his peak in the 1940s, Michael Powell was in the top ranks of British film directors, alongside such contemporaries as David Lean, Carol ReedREAD more
27 Aug 2008 // 10:59 PM
Powell's groundbreaking blend of art and terror cut short a career at its most innovative moment.READ more
26 Jun 2008 // 10:58 PM
Let's hope that one day such wonder at Baghdad will be possible, again.READ more
15 Dec 2003 // 1:00 AM
Michael Powell's work reveals the unshakable conviction that film should overwhelm the audience with an artist's deliberately crafted vision.READ more
//Mixed media
Colette Carr "Static" (video) (Premiere) // Music
House of Blondes "First of July" (audio) (premiere) // Music
Digisaurus 'No More Room For Love' (EP stream) // Music
Eszter Balint 'Airless Midnight' (album stream) (premiere) // Music
//Pm Picks
PopMatters is on a short summer publishing break. We resume Monday, July 6th.
// Announcements
"PopMatters is on a short summer publishing break. We resume Monday, July 6th.READ the article


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text:
Hotel Seehof Accommodation & Rooms
- Free buffet breakfast and WiFi
Main amenities
- 20 smoke-free guestrooms
- 1 restaurants
- Coffee/tea in the lobby
- Daily housekeeping
- Front desk safe
- Laundry service
- Limited hour front desk
- Tour/ticket assistance
What's around
- In Seefeld
- Kunsthaus Zurich (0.6 mi / 1 km)
- Fraumuenster (0.7 mi / 1.1 km)
- Bahnhofstrasse (0.7 mi / 1.1 km)
Breakfast, location and staff friendliness as excellent. The room was a bit run down and…
This is a nice and clean Hotel. It is idealfora business trip for oneor two days. It…
Enter dates to check prices
Hotel Info: .from ZAR 2,092
- Junior Suite
- Standard Single Room
- Standard Twin Room
- Superior Double Room
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 20 rooms
- This hotel is arranged over 5 floors
- Check-in time 3 PM-10 PM
- Check-out time is noon
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Children (6 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets allowed *
Extra people
- Rollaway beds available, charges may apply*
- Free WiFi in public areas
- Free WiFi in rooms
Other information
- Smoke-free property
Nearby Three Star Zurich hotels
In the hotel
- Free buffet breakfast daily
- Breakfast (surcharge)
- 1 restaurants
- Bar/lounge
- Coffee/tea in the lobby
- Personal motorized watercraft on site
- Bicycle rentals nearby
- Hiking/biking trails nearby
- Mountain biking nearby
- Scooter/moped rentals nearby
- Front desk (limited hours)
- Tours/ticket assistance
- Dry cleaning/laundry service
- Number of buildings/towers - 1
- Elevator/lift
- Safe-deposit box at front desk
- In-room accessibility
- Roll-in shower
In the room
- Minibar
- Bathrobes
- Slippers
- Iron/ironing board (on request)
- Hypo-allergenic bedding available
- Blackout drapes/curtains
- Turndown service
- Premium bedding
- Private bathroom
- Shower only
- Free toiletries
- Hair dryer
- Cable TV channels
- Desk
- Free newspaper
- Free WiFi
- Daily housekeeping
- In-room safe
Top Zurich hotels
Recently reviewed hotels in Zurich
- Central Plaza HotelFrom
"The hotel is right in Main attraction of Zurich centre.Liked mostly that I could walk to Bahnofstrasse several times a day.Good views of the river and the hotel bar is also very…"Mar 26, 2015
- Ameron Hotel FloraFrom
"The hotel was good. Staff was OK. Rooms were quite small."Jan 30, 2015
- Novotel Zurich City WestFrom
"We've stayed at Novotel City West from 1-3 Jan 2015. The breakfast was really good value for money. Hotel is not in city center but easily accessible with Tram 4 which stop behind…"Jan 12, 2015
- Waldstaetterhof Swiss Quality HotelFrom
"Our family of four stayed at the hotel for one night. The staff and food was amazing with the children."Jan 9, 2015
Nearby hotels
Special features
DiningOnsite venue - This restaurant serves lunch and dinner. Guests can enjoy drinks at the bar.
Hotel Seehof Accommodation & Rooms's small print
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- Tourism fee: CHF 2.50 per person, per night
Optional extras
Parking is available nearby and costs CHF 25 per 24 hours
Rollaway beds are available for CHF 40 per night
Breakfast is offered for an extra charge of CHF 20 per person (approximately)
Pets are allowed for an extra charge of CHF 10 per pet, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
Cadillac Eldorado Problem Report
Cadillac Eldorado Stalling Due to Failed Crankshaft Position Sensor
(26 reports)
The crankshaft position sensor may fail causing the engine to stall intermittently, the Check Engine Light may or may not illuminate.
I think i'm having a similar problem. Car will just die after its warmed up and driving around town. I keep blowing fuel pump fuses. check engine like is on . - Visitor
1 person likes this
i've owned 3 cadillacs and an aurora wich runs the same engine as cadillac and had the same problem with all 4 vehicles, they all stall at traffic stops. I was told by the dealership mechanic that this is a common problem due to the casing of the sensor becoming brittle by the engine heat. - Visitor
1 person likes this
Stalls when I make a left turn from a turn lane with a light pluslikes to idel up when sitting in traffic - Visitor
I replaced a seal in the transmison i had to take out the transmision put it back put everything back like it was now it will trun over but want start and i dont have spark - Visitor
changed crankshaft sensor and camshaft sensor - Visitor
car just stops running when slowing down - chunkydunk
Engine would falter or completely stall or would be hard to restart after the engine was warmed up. Replacement of both upper and lower sensors. Located just above the oil filter. - Visitor
Car will idle alright and drive good then when i come to a stop the car will cut off. The amazing thing is the dealership charged me 1,500 dollars and said it was fixed , however the car is still shutting off. They said it wasalot of gas in the intake. - Early
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Nurses Week, which started on May 6th, acknowledges the commitment, compassion and care nurses display while practicing their profession. This is a week that COTA celebrates the nurses we know and care about; to reflect on the power of their profession; and to salute them.
This year's National Nurses Week theme is "Ethical Practice. Quality Care."
The hallmark of an ethical professional is shown in the quality of patient care that is delivered when no one else is watching. When your patient can't speak your language. When you will walk away a week after your job and you will never see that patient again. When you know that malpractice is not an option, hospital administration oversight is minimal and peer reviews are not an issue....but you do the job just as you would if those pressures were present.
Children of the Americas had 28 of those kind of nurses on our recent medical team in San Benito, Guatemala this past January. Twenty eight people who were ethical, competent and altruistic and treated each patient just like they would have if they were practicing their profession in the United States.
Without our nurses, patients would not have had their needs met, surgeons would be missing expert staff to pass instruments and prep patients, and post operative care would have been missing without our team nurses.
Our nurse volunteers are our support system: our foundation.They spent a week working long hours while paying their own expenses to travel with us. They give up vacation time that could have been used to be with their families. COTA nurses return to the United States with empty pockets, tired feet and a major dose of fatigue. Our organization could not ask more of them because they already give 110%.
In short, we would not have had a medical team.


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Are you Isaac Chiu?Claim your profile
Publications (16)157.92 Total impact
- SourceAvailable from: David Strochlic
Article: Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity[Show abstract] [Hide abstract]
ABSTRACT: The somatosensory nervous system is critical for the organism's ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are functionally and anatomically diverse but their molecular profiles are not well-defined. Here, we used transcriptional profiling to analyze the detailed molecular signatures of dorsal root ganglion (DRG) sensory neurons. We used two mouse reporter lines and surface IB4 labeling to purify three major non-overlapping classes of neurons: 1)IB4(+)SNS-Cre/TdTomato(+), 2)IB4(-)SNS-Cre/TdTomato(+), and 3)Parv-Cre/TdTomato(+) cells, encompassing the majority of nociceptive, pruriceptive, and proprioceptive neurons. These neurons displayed distinct expression patterns of ion channels, transcription factors, and GPCRs. Highly parallel qRT-PCR analysis of 334 single neurons selected by membership of the three populations demonstrated further diversity, with unbiased clustering analysis identifying six distinct subgroups. These data significantly increase our knowledge of the molecular identities of known DRG populations and uncover potentially novel subsets, revealing the complexity and diversity of those neurons underlying somatosensation.eLife Sciences 12/2014; 3. DOI:10.7554/eLife.04660 · 8.52 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Reprogramming somatic cells from one cell fate to another can generate specific neurons suitable for disease modeling. To maximize the utility of patient-derived neurons, they must model not only disease-relevant cell classes, but also the diversity of neuronal subtypes found in vivo and the pathophysiological changes that underlie specific clinical diseases. We identified five transcription factors that reprogram mouse and human fibroblasts into noxious stimulus-detecting (nociceptor) neurons. These recapitulated the expression of quintessential nociceptor-specific functional receptors and channels found in adult mouse nociceptor neurons, as well as native subtype diversity. Moreover, the derived nociceptor neurons exhibited TrpV1 sensitization to the inflammatory mediator prostaglandin E2 and the chemotherapeutic drug oxaliplatin, modeling the inherent mechanisms underlying inflammatory pain hypersensitivity and painful chemotherapy-induced neuropathy. Using fibroblasts from patients with familial dysautonomia (hereditary sensory and autonomic neuropathy type III), we found that the technique was able to reveal previously unknown aspects of human disease phenotypes in vitro.Nature Neuroscience 11/2014; DOI:10.1038/nn.3886 · 14.98 Impact Factor
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ABSTRACT: An L-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, contrasting to the properties of monomeric L-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the first example of the supramolecular assemblies of a saccharide to suppress immunity, this work illustrates a new approach of immunomodulation.Organic & Biomolecular Chemistry 07/2014; 12(35). DOI:10.1039/C4OB01362J · 3.49 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviours. Bacterial infections produce pain by unknown molecular mechanisms, although they are presumed to be secondary to immune activation. Here we demonstrate that bacteria directly activate nociceptors, and that the immune response mediated through TLR2, MyD88, T cells, B cells, and neutrophils and monocytes is not necessary for Staphylococcus aureus-induced pain in mice. Mechanical and thermal hyperalgesia in mice is correlated with live bacterial load rather than tissue swelling or immune activation. Bacteria induce calcium flux and action potentials in nociceptor neurons, in part via bacterial N-formylated peptides and the pore-forming toxin α-haemolysin, through distinct mechanisms. Specific ablation of Nav1.8-lineage neurons, which include nociceptors, abrogated pain during bacterial infection, but concurrently increased local immune infiltration and lymphadenopathy of the draining lymph node. Thus, bacterial pathogens produce pain by directly activating sensory neurons that modulate inflammation, an unsuspected role for the nervous system in host-pathogen interactions.Nature 08/2013; DOI:10.1038/nature12479 · 42.35 Impact Factor
Article: A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model.[Show abstract] [Hide abstract]
ABSTRACT: Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo. Analysis of resting microglia identified 29 genes that distinguish microglia from other CNS cells and peripheral macrophages/monocytes. We then analyzed molecular changes in microglia during neurodegenerative disease activation using the SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS). We found that SOD1(G93A) microglia are not derived from infiltrating monocytes, and that both potentially neuroprotective and toxic factors, including Alzheimer's disease genes, are concurrently upregulated. Mutant microglia differed from SOD1(WT), lipopolysaccharide-activated microglia, and M1/M2 macrophages, defining an ALS-specific phenotype. Concurrent messenger RNA/fluorescence-activated cell sorting analysis revealed posttranscriptional regulation of microglia surface receptors and T cell-associated changes in the transcriptome. These results provide insights into microglia biology and establish a resource for future studies of neuroinflammation.Cell Reports 07/2013; DOI:10.1016/j.celrep.2013.06.018 · 7.21 Impact Factor
Article: Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.[Show abstract] [Hide abstract]
ABSTRACT: The peripheral nervous and immune systems are traditionally thought of as serving separate functions. The line between them is, however, becoming increasingly blurred by new insights into neurogenic inflammation. Nociceptor neurons possess many of the same molecular recognition pathways for danger as immune cells, and, in response to danger, the peripheral nervous system directly communicates with the immune system, forming an integrated protective mechanism. The dense innervation network of sensory and autonomic fibers in peripheral tissues and high speed of neural transduction allows rapid local and systemic neurogenic modulation of immunity. Peripheral neurons also seem to contribute to immune dysfunction in autoimmune and allergic diseases. Therefore, understanding the coordinated interaction of peripheral neurons with immune cells may advance therapeutic approaches to increase host defense and suppress immunopathology.Nature Neuroscience 07/2012; 15(8):1063-7. DOI:10.1038/nn.3144 · 14.98 Impact Factor
Article: Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction[Show abstract] [Hide abstract]
ABSTRACT: Coronary artery occlusion resulting in ischaemia/reperfusion (I/R) injury is a major cause of mortality in the western world. Circulating natural IgM has been shown to play a significant role in reperfusion injury, leading to the notion of a pathogenic response against self by the innate immune system. A specific self-antigen (non-muscle myosin heavy chain II) was recently identified as the major target of pathogenic natural IgM. Therefore, we hypothesized that a synthetic peptide mimetope (N2) or monoclonal antibodies directed against the self-antigen would prevent specific IgM binding to the self-antigen and reduce reperfusion injury in the heart. We find that treatment with N2 peptide reduces infarct size by 47% and serum cardiac troponin-I levels by 69% following 1 h ischaemia and 24 h reperfusion. N2 peptide or an anti-N2 F(ab')(2) (21G6) is also effective at preventing IgM and complement deposition. Additionally, N2 peptide treatment significantly reduces monocyte and neutrophil infiltration at 24 h and collagen deposition at 5 days. Finally, we show that human IgM (hIgM) also includes specificity for the highly conserved self-antigen and that myocardial injury in antibody-deficient mice reconstituted with hIgM is blocked by treatment with N2 peptide or 21G6 F(ab')(2). The findings in this study identify potential therapeutics [i.e. N2 peptide or 21G6 F(ab')(2)] that prevent specific IgM binding to ischaemic antigens in the heart, resulting in a significant reduction in cardiac I/R injury.Cardiovascular Research 06/2010; 87(4):618-27. DOI:10.1093/cvr/cvq141 · 5.81 Impact Factor
Article: Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.[Show abstract] [Hide abstract]
ABSTRACT: During injury to the nervous system, innate immune cells mediate phagocytosis of debris, cytokine production, and axon regeneration. In the neuro-degenerative disease amyotrophic lateral sclerosis (ALS), innate immune cells in the CNS are activated. However, the role of innate immunity in the peripheral nervous system (PNS) has not been well defined. In this study, we characterized robust activation of CD169/CD68/Iba1+ macrophages throughout the PNS in mutant SOD1(G93A) and SOD1(G37R) transgenic mouse models of ALS. Macrophage activation occurred pre-symptomatically, and expanded from focal arrays within nerve bundles to a tissue-wide distribution following symptom onset. We found a striking dichotomy for immune cells within the spinal cord and PNS. Flow cytometry and GFP bone marrow chimeras showed that spinal cord microglia were mainly tissue resident derived, dendritic-like cells, whereas in peripheral nerves, the majority of activated macrophages infiltrated from the circulation. Humoral antibodies and complement localized to PNS tissue in tandem with macrophage recruitment, and deficiency in complement C4 led to decreased macrophage activation. Therefore, cross-talk between nervous and immune systems occurs throughout the PNS during ALS disease progression. These data reveal a progressive innate and humoral immune response in peripheral nerves that is separate and distinct from spinal cord immune activation in ALS transgenic mice.Proceedings of the National Academy of Sciences 11/2009; 106(49):20960-5. DOI:10.1073/pnas.0911405106 · 9.81 Impact Factor
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ABSTRACT: Amyotrophic Lateral Sclerosis (ALS) is an adult-onset, progressive, motor neuron degenerative disease, in which the role of inflammation is not well established. Innate and adaptive immunity were investigated in the CNS of the Superoxide Dismutase 1 (SOD1)(G93A) transgenic mouse model of ALS. CD4+ and CD8+ T cells infiltrated SOD1(G93A) spinal cords during disease progression. Cell-specific flow cytometry and gene expression profiling showed significant phenotypic changes in microglia, including dendritic cell receptor acquisition, and expression of genes linked to neuroprotection, cholesterol metabolism and tissue remodeling. Microglia dramatically up-regulated IGF-1 and down-regulated IL-6 expression. When mutant SOD1 mice were bred onto a TCRbeta deficient background, disease progression was significantly accelerated at the symptomatic stage. In addition, microglia reactivity and IGF-1 levels were reduced in spinal cords of SOD1(G93A) (TCRbeta-/-) mice. These results indicate that T cells play an endogenous neuroprotective role in ALS by modulating a beneficial inflammatory response to neuronal injury.Proceedings of the National Academy of Sciences 12/2008; 105(46):17913-8. DOI:10.1073/pnas.0804610105 · 9.81 Impact Factor
- Molecular Immunology 10/2008; 45(16):4163-4163. DOI:10.1016/j.molimm.2008.08.203 · 3.00 Impact Factor
Article: Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action.[Show abstract] [Hide abstract]
ABSTRACT: Increased expression of adhesion molecules by activated endothelium is a critical feature of vascular inflammation associated with the several diseases such as endotoxin shock and sepsis/septic shock. Our data demonstrated complement regulatory protein C1 inhibitor (C1INH) prevents endothelial cell injury. We hypothesized that C1INH has the ability of an anti-endothelial activation associated with suppression of expression of adhesion molecule(s). C1INH blocked leukocyte adhesion to endothelial cell monolayer in both static assay and flow conditions. In inflammatory condition, C1INH reduced vascular cell adhesion molecule (VCAM-1) expression associated with its cytoplasmic mRNA destabilization and nuclear transcription level. Studies exploring the underlying mechanism of C1INH-mediated suppression in VCAM-1 expression were related to reduction of NF-kappaB activation and nuclear translocation in an IkappaBalpha-dependent manner. The inhibitory effects were associated with reduction of inhibitor IkappaB kinase activity and stabilization of the NF-kappaB inhibitor IkappaB. These findings indicate a novel role for C1INH in inhibition of vascular endothelial activation. These observations could provide the basis for new therapeutic application of C1INH to target inflammatory processes in different pathologic situations.Biochemical and Biophysical Research Communications 08/2007; 358(4):1120-7. DOI:10.1016/j.bbrc.2007.05.058 · 2.28 Impact Factor
Article: Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis[Show abstract] [Hide abstract]
ABSTRACT: Toll receptors in Drosophila melanogaster function in morphogenesis and host defense. Mammalian orthologues of Toll, the Toll-like receptors (TLRs), have been studied extensively for their essential functions in controlling innate and adaptive immune responses. We report that TLR8 is dynamically expressed during mouse brain development and localizes to neurons and axons. Agonist stimulation of TLR8 in cultured cortical neurons causes inhibition of neurite outgrowth and induces apoptosis in a dissociable manner. Our evidence indicates that such TLR8-mediated neuronal responses do not involve the canonical TLR-NF-kappaB signaling pathway. These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity.The Journal of Cell Biology 11/2006; 175(2):209-15. DOI:10.1083/jcb.200606016 · 9.69 Impact Factor
Article: Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury[Show abstract] [Hide abstract]
ABSTRACT: Complement activation augments myocardial cell injury and apoptosis during ischemia/reperfusion (I/R), whereas complement system inhibition with C1 inhibitor (C1INH), a serine protease inhibitor, exerts markedly cardioprotective effects. Our recent data demonstrate that C1INH prevents vascular endothelial cell apoptosis and a "modified" form of the reactive center loop-cleaved, inactive C1INH (iC1INH) plays an anti-inflammatory role in endotoxin shock. The aim of this study was to determine whether C1INH protects against myocardial cell injury via an anti-apoptotic activity or anti-inflammatory effect. In a rat model of acute myocardial infarction (AMI) induced by I/R, administration of C1INH protected against cardiomyocytic apoptosis via normalization of ratio of the Bcl-2/Bax expression in the myocardial infarct area. C1INH improved parameters of cardiac function and hemodynamics and reduced myocardial infarct size (MIS). In addition, myocardial and blood myeloperoxidase (MPO) activity, a marker of neutrophil infiltration, was decreased by treatment of C1INH. In cultured H9c2 rat cardiomyocytic cells, C1INH blocked hypoxia/reoxygenation-induced apoptosis in the absence of sera associated with inhibition of cytochrome c translocation and suppression of caspase-3 activation. The proportion of Bcl-2/Bax expression induced by hypoxia/reoxygenation was reversed by C1INH. Importantly, iC1INH also revealed these similar effects, indicating that C1INH has a direct anti-apoptotic activity. Therefore, these studies support the hypothesis that C1INH, in addition to inhibition of activation of the complement and contact systems, improves outcome in I/R-mediated myocardial cell injury via an anti-apoptotic activity independent of serine protease inhibitory activity.Biochemical and Biophysical Research Communications 11/2006; 349(2):504-12. DOI:10.1016/j.bbrc.2006.08.065 · 2.28 Impact Factor
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ABSTRACT: Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.Journal of Experimental Medicine 02/2006; 203(1):141-52. DOI:10.1084/jem.20050390 · 13.91 Impact Factor
Article: Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury.[Show abstract] [Hide abstract]
ABSTRACT: Reperfusion injury of ischemic tissue represents an acute inflammatory response that can cause significant morbidity and mortality. The mechanism of injury is not fully elucidated, but recent studies indicate an important role for natural antibody and the classical pathway of complement. To test the hypothesis that injury is initiated by specific IgM, we have screened a panel of IgM-producing hybridomas prepared from peritoneal cells enriched in B-1 cells. One clone, CM22, was identified that could restore pathogenic injury in RAG-1(-/-) mice in an intestinal model of ischemia/reperfusion (I/R). In situ activation of the classical pathway of complement was evident by deposition of IgM, complement C4, and C3 in damaged tissue after passive transfer of CM22 IgM. Sequence analysis of CM22 Ig heavy and light chains showed germ-line configurations with high homology to a V(H) sequence from the B-1 repertoire and a V(K) of a known polyreactive natural IgM. These data provide definitive evidence that I/R injury can be initiated by clonally specific natural IgM that activates the classical pathway of complement. This finding opens an avenue for identification of I/R-specific self-antigen(s) and early prevention of injury.Proceedings of the National Academy of Sciences 04/2004; 101(11):3886-91. DOI:10.1073/pnas.0400347101 · 9.81 Impact Factor
Article: Identification of a specific self-reactive IgM antibody that initiates intestinal ischemiareperfusion injury
Top Journals
Harvard UniversityCambridge, Massachusetts, United States
Harvard Medical School
Boston, Massachusetts, United States
- • Department of Pathology
- • Department of Neurology
Boston Children's Hospital
Boston, Massachusetts, United States
- F.M. Kirby Neurobiology Center
Boston Therapeutics, Inc.Manchester, New Hampshire, United States


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The incident took place when Ashok along with his brother Sunil Kumar, 48, had gone to the market and their motorcycle hit a woman near the Sham Palace where a marriage party was going on.
SHO of the area Brij Mohan, who recorded the statement of Sunil Kumar, said the two brothers were going to the market when their two-wheeler hit a woman who was going along with a group.
"Soon after the incident, a group came from inside the marriage party and started beating the brothers. Somehow, Sunil managed to flee from the spot, but the mob caught Ashok and beat him up to death," the SHO said.
He said the four persons, all from the marriage party, were arrested and a case section 302 of the IPC had been registered under.
"We are looking for 17 persons who are also involved in beating up the victim," Brij Mohan said.
Those arrested have been identified as Ashish Kumar of Manimajra, Manga Masi of Amritsar, Amandeep and Abhishek, both residents of Esanagri.


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Phoenix Suns
Report: Phoenix Suns are in the market for Pau Gasol
While the Phoenix Suns hope to make a splash with the most high profile free agents available, a report emerged that the Suns will attempt to lure another big name to the desert.
ESPN's Ramona Shelburne tweeted Monday that the Suns are expected to compete with the Atlanta Hawks, Los Angeles Lakers, New York Knicks, Chicago Bulls, Dallas Mavericks and Houston Rockets for the services of big man Pau Gasol, who has played with the Lakers for the last six-plus seasons.
Add two teams to the expected Pau Gasol market: Phoenix and Atlanta. Lakers, Knicks, Bulls, Mavs, Rockets all expected to pursue.— Ramona Shelburne (@ramonashelburne) July 1, 2014
Gasol averaged 17.4 points and 9.7 rebounds in Los Angeles last season, and the Suns were linked to him in trade talks near the trade deadline. Given Channing Frye's possible departure through free agency, it makes sense that the Suns would be in the market for a big man with the ability to score.
The Suns have a plethora of space to maneuver under the salary cap, though a chunk of that is expected to go to Eric Bledsoe. The possible addition of Gasol would add him to a Suns frontcourt that includes the likes of Markieff and Marcus Morris and Miles Plumlee.
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- Yay or Nay?Will Eric Bledsoe be a Sun next season? Was Chandler the best "Friend"? and more questions
- Ric Bucher, Bleacher Report NBA writerDo the Suns have a shot at LaMarcus Aldridge and more free agency talk
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- Israel Gutierrez, ESPN NBA writerWhere will LaMarcus Aldridge go and what will the Suns do in free agency?


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"The address labels came out very nice. It looks elegant for a wedding invite or to use for every day maIl. Happy with product"
"I bought these to match the thank you cards in this same print for my daughter. I just think it is so adorable that the same woodland creatures on her card are now "peeking" on these address labels!"
"I didn't really change it up all that much. The print and design is clean and very pretty. I chose the blue/red combo. I am always happy with Tiny Prints products and would recommend this lovely label. Great quality print and paper."
"This was my first experience with the site and creating an anniversary card. It came out "great". An updated and modern design for a 50th anniversary card from the typical usual selection. The quality of the paper was excellent. I will use them again. Very satisfied."
"The image you see in the sample on the website is exactly what you get in hard copy! Fonts are easily read and label size is appropriate for all letter sizes. I really liked the ability to customize the colors on the labels. Great quality too. Would recommend to a friend."


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The French architect Jean Nouvel has announced details of his design for the National Art Museum of China in Beijing. [...]
"The National Art Museum of China represents an incredible opportunity for the most ambitious materialisation of a place of expression… a place that witnesses the vitality of a civilisation, the civilisation of the greatest people on earth," say the organisers. — theartnewspaper.com
Previously: Jean Nouvel Confirmed as Winner of the National Art Museum of China Competition View full entry »
[...] colleges in China are copying America's copycat approach. There's a university in Shanghai where faux English manor houses sit side-by-side with dorms modeled on Britain's half-timbered homes. To the north, Hebei province boasts a university inspired by Harry Potter's Hogwarts—itself fashioned on the traditional collegiate Gothic. Even specific colleges have been cloned. — theatlantic.com
Friday, September 12:Vincent Scully Prize 2014 awarded to journalist and TV host Charlie Rose: The prize was established by the National Building Museum in 1999, and is named after the famed Yale art history and architecture professor who helped establish Louis Kahn and Robert Venturi. Rose was... View full entry »
"Giving the boulevard back to the people... makes the streets habitable again," says Sean O'Malley of SWA. — swa group
How does a 10-block neighborhood intervention of volunteers in Highland Park, Los Angeles link to a $325 million streetscape and storm water infrastructure transformation in Shenzhen, China? "This is about giving the street and the boulevard back to the people," says Sean O'Malley... View full entry »
But I've seen aerial photographs of this place taken by the Philippine navy. They show the massive land reclamation work China has been doing here since January.
Millions of tonnes of rock and sand have been dredged up from the sea floor and pumped into the reef to form new land. — BBC News
Rupert Wingfield-Hayes travels to the South China Sea, where the Chinese state is building islands. View full entry »
Residents of Beijing can use one of the city's 34 newly installed recycling machines to trade empty bottles for phone card rebates or free public transit passes.
Those who choose the phone card rebate just need to type in their phone numbers or scan their cards and the rebate will be automatically applied.
The value of the rebate will correspond to the value of the type of bottle that was recycled. — pangeatoday.com
Read the original Chinese language report here. View full entry »
Architecture theorist Jacob Dreyer explains how the Stalinist model of urbanism – a centrally planned component within a national economic unity – is thriving in modern China — theguardian.com
Friday, August 29:MIT's MindRider helmet draws mental maps as you bike: The prototype is currently being used to create a mental-map and guidebook for NYC, and an upcoming Kickstarter campaign will attempt to fund the project for commercial sale.In Beirut, a grassroots push for more grass... View full entry »
In use since September 1, 2014, an elementary school in Tiantai, Zhejiang province, built a 200-meter running track on the roof of its school building. In "School puts running track on its roof" Chinese architect Ruan Hao [LYCS Architecture], chief architect of the teaching building, said "that... View full entry »
State-owned news outlets reported this month that the government would ban the use of coal in Beijing and other urban areas by 2020 in an effort to reduce the noxious air pollution that chokes many cities. [...]
But [President Xi Jinping] and other officials have provided few details — and, indeed, have sent conflicting, even disturbing, signals about their plans. Some measures China is considering could actually exacerbate climate change. — nytimes.com
In the wake of economic reforms in the 1990s that helped set off the largest urban migration in history, China had the rare opportunity to embrace cutting-edge city-building approaches as it expanded its skyline. It could have avoided the mistakes that made Los Angeles into the land of gridlock, or bypassed the errors that turned the banlieues of Paris into what one American planner calls "festering urban sores".
But China looked back instead of forward. — theguardian.com
Meanwhile in Africa: Urban China: Chinese Urbanism in Africa View full entry »
It is not rare for a civilisation to abruptly falter, give way and fold into a new one. This insight seems obvious in the territories of the former Soviet Union — a universe transformed into a memory overnight. [...] that a city turned ruin continues to be inhabited, that the collapsing buildings and boulevards stained by a thousand footsteps, after the apocalypse, host new forms of human life, new memories. Harbin, in the far north-east of China, used to be a very Russian metropolis. — calvertjournal.com
China's visible impact on urban development in Africa is substantial. One need only take a virtual bird's-eye tour on Google Earth to catch a glimpse of some of the most impressive changes brought to Africa by Chinese constructors, developers and designers. Not far from the Angolan capital of Luanda lies arguably one of the most impressive examples: Kilamba New City. A massive housing development designed to accommodate 500,000 people [...]. — gowestproject.com
The Chinese government issued proposals on Wednesday to break down barriers that a nationwide household registration system has long imposed between rural and urban residents and among regions, reinforcing inequality, breeding discontent and hampering economic growth.
Yet even as officials promoted easier urbanization [...], they said changes to the system [...] must be gradual and must protect big cities like Beijing. — nytimes.com
China has announced plans to ban the use of coal in its smog-plagued capital by the end of 2020, as the country fights deadly levels of pollution, especially in major cities.
Beijing's Municipal Environmental Protection Bureau posted the plan on its website on Monday, saying the city would instead prioritize electricity and natural gas for heating.
The Chinese central government recently listed environmental protection as one of the top criteria by which leaders will be judged. — Al Jazeera
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News ArchivesRead News
Italian doctor to present research on Irish set dancing as remedy for Parkinson's
Tuesday July 23, 2013
Jane Walsh
Irish Central - An Italian Doctor's chance discovery of the therapeutic effects of Irish set dancing in the treatment of Parkinson's disease will be the subject of an international Gathering event in Co. Clare next month.
Dr Daniel Volpe who is the Director of Neurological Rehabilitation at St. Raffaele Arcangelo Hospital in Venice will present his research work confirming the benefits of set dancing in the rehabilitative therapy for people with Parkinson's disease.
As part of the 26th Annual International Traditional Music Festival in Feakle, the Italian neurologist will present his latest research on "The Therapeutic Effects of Irish Set Dancing in the Treatment of Parkinson's Disease." The Conference will feature a series of lectures, workshops, set dancing, sean-nós dancing and a Céilí.
Dr Volpe be accompanied by the set dancing fraternity from Venice and Italian musicians.
The event will tie in with the world renowned Feakle International Festival of Traditional Music in County Clare from August 5th-7th August 2013.
World renowned Irish traditional musicians Martin Hayes and Dennis Cahill will provide the musical accompaniment for a demonstration of Irish Dancing with Parkinson's disease patients from Italy and Ireland. Meanwhile, there will be a workshop of set dancing in Parkinson's for set dancing tutors and people with the disease.
Guest speakers at the conference include Prof Timothy Lynch, Consultant Neurologist, Mater University Hospital, Dublin, Dr Amanda Clifford, Lecturer, and Joanne Shanahan, MSc Research Student, University of Limerick.
Event spokesperson Pat Hayes described the background to Dr. Volpe's research.
"During one of his regular visits to County Clare to play with his traditional Irish music band, Dr Volpe watched as a man he recognised as suffering from Parkinson's disease walked into the room. Dr Volpe later watched in astonishment as the man who earlier had struggled to walk, took part in the festivities and set danced without any difficulty."
He added: "Afterwards, Dr Volpe, who works in developing physiotherapy for people with Parkinson's disease, took it upon himself to learn a bit more about the reel step. He conducted a study that found Irish dancing does, indeed, have positive effects for those suffering from Parkinson's disease."
He concluded: "We are delighted to be hosting this unique event and have no doubt that it will focus in on the value of Irish music and dance."
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May 21 - Study suggests depression is precursor to Parkinson's disease
May 15 - Parkinson's disease increasing, but so are better treatments


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Yet another birthday has come and gone. And while last year I was rebellious and decided to celebrate with and overdose of nutella in my birthday party dessert, (as is proper in any birthday party, anywhere, ever) this year I indulged instead in a mile high cake. Because I'm piling on the years, I figured it's only fitting to pile on the size of the cake. This cake, with it's polished and big look, has many steps to it, but it's actually very easy and quick to make, (compared to other -cup- cakes I've made) so it was a great choice for a hectic day, in which I ran all across the city since morning and only started to prepare a full make your own grilled cheese bar about 1 hour before the guests arrived. My lateness, and the unpredictable may weather, resulted in what looked very much like an english tea party, instead of lunch. But who's complaining? You can hardly beat a late lunch with rainy weather, flowers and cake. And gin and tonics instead of tea, of course! Tempted to do the same? Read more for the recipe! Continue reading
Fun in the sun – Amaranth fish tacos with mango sauce
It's already been 8 days since spring officially started, and oddly enough I spent most of my weekend curled up with a book and a glass of wine, reading by the window because there was hardly any sun, and it poured cats and dogs most of saturday and all of sunday. Not that I'm complaining, rainy weather is my favourite kind. In my opinion, summer is a month (or two) too long here in Mexico. But spring is my second favorite. Because spring means seafood, rosé and sunny terraces. And light dresses and a friendly sun, not a scorching-I-feel-menopausic-one. And that's exactly why I prepared this recipe for the weekend, because it's the perfect meal to enjoy on this time of the year. It's fresh, mexican, delicious, and healthy.
I've raved about amaranth as a substitute for breading before, right here, and this time I won't do it again. Instead I'll rave about the colourful, yummy combination that's purple cabbage, with avocado, cilantro and different favoured tortillas. But as if all of those together weren't enough, why not top it off with a scrumptious spicy mango sauce? Still not enough? Then a second, creamy labneh and cilantro dressing will make absolutely everyone happy. You can dress your tacos with either of the sauces, or as one of naughty guests did, mix them both in the same taco! However you eat them, make sure you have plenty of tortillas, because you'll probably end up having one too many tacos. (As is usually the case with tacos, of any kind)
Recipe after the jump.
The killer combo – Chocolate, banana & almond tart
Recently I've had a ton of birthdays. I don't know why, but March seems to be a popular month amongst people near me to turn older and remind me that in a few more months I will also be adding a year to my belt. This of course, after you've passed the 25 mark, is always catastrophic. And while I know that I'm not ancient and that not only the blogging world but the world in general is full of articles praising your late 20's and telling you how it's the best time of your life, it still panics me a bit to be reminded I'm also getting older. But. Birthdays also remind me that I have an excuse to eat tons of dessert, have too many drinks and in general be merry. Because as we get older our celebrations evolve with us, and, to my great enjoyment, increasingly involve better food and more importantly, more dessert. (And thankfully, more wine and less tequila shots). But the truly great thing about birthday desserts, is that you get to enjoy them like a little kid, because when you get a killer combo of sweet ingredients that take you back to that very first birthday when you put bananas and chocolate in your mouth, and realised the world was in fact a great place worth making a life in, we all become little kids. And in that moment the crow's feet round your eyes are purely from smiling. (Except for those unfortunate souls who don't like chocolate.). This tart, with it's chocolate ganache, fresh bananas, toasted almonds and whipped cream topping, will actually make you wish you had even more reasons to feel old, just so you could whip one up once a week.
Note: while this tart is very easy to make, if you're not comfortable making tart shells or are in a hurry, feel free to swap the one in the recipe for a store bought one. Just make sure it's chocolate! Recipe after the jump. Continue reading
Not gone forever – Soft butterflake garlic parmesan rolls
Well hello there! I know I disappeared for over six months and that I am shameless. But it wasn't only a disappearance from the foodieblogosphere, (yup, that's a word) I also had to momentarily ditch my faithful kitchen. This was however, all for a good reason. I've been working like crazy on a new project and I just simply didn't have the time to cook anything more elaborate than a sandwich or the occasional birthday cake. The project in question, which took me away from my whisks and bowls of sugar, is the just-launched art & design store, wolfrikdesign.com. I am so excited about it I haven't even missed my kitchen-aid! (*gasp*) It's all about finding unique artists & designers, curating the store, designing everything…..and so on. Please be sure to go check it out! You'll make me very very happy. But back to the kitchen note, now things have settled a bit and I have some time (and mental space) to get my hands covered in flour and to increase my calorie count. And to debut, here are some garlic-parmesan butterflake rolls to get started. They are similar to monkey bread, but instead of chunks they're made up of slices. These rolls are great for an italian inspired lunch, I recommend you serve them with olive oil and balsamic vinegar for dipping. The soft dough soaks it right up, mixing with the garlic and parmesan for gooey goodness in your mouth. Garlic-parmesan is no brainer, so go and get this super easy and impressive recipe going!
Recipe after the jump ->
Pack a punch – Almond cocoa energy squares
My ankle (which has been out of order on and off this whole year) is finally healing a little bit. Which means I can start running again. And even though I haven't done more than 20 minutes on the treadmill and I'm not allowed to jump yet (I know. It's catastrophic) I can make energy bars. These delicious little squares will satisfy your morning sweet tooth while giving you a full energy boost; they're made of oats, which are a great source of slow-release energy and fiber. Almonds, your classic super food (is there any body system they're not good for?). Raisins, full of the good kinds of sugar to give you an up and which also help absorb vitamins and proteins, along with promoting a healthy digestive system. Flaxseed, also for great digestion but adding omega-3 and tons of other good side-effects such as fighting liver disease and lowering cholesterol. Cocoa powder, which is suspected of boosting endorphins and serotonin (aka, make you happy!) apart from being highly antioxidant. Wrap all of these up with some honey (which has, apart from all it's other properties, been proven to increase athletic performance and reduce recovery time) and you get ultra healthy, sugar free bites of delicious fitness. I cut up mine small because I like bite-sized things, but feel free to turn these into bars to take on the go, or to add some protein powder! Read more for the recipe.
Post monday – Greek yogurt chocolate banana muffins
Some things are just universally loved. Like finding money in your pockets or banana muffins for breakfast. Other things are universally hated, like smashing your little toe against a table, or mondays. Most people find mondays truly horrible; it's the day they have to get up early again, go to work, and accept the fact that there are five more days of the same before the weekend comes again. I, on the other hand, happen to be a complete lunatic and absolutely love mondays. And don't get me wrong, I love weekends as well… but they just take a huge toll on my doing-things-I-love-on-my-own schedule. For example, I can never have the discipline to work out on weekends. Or to walk my dogs, or read, or try out new recipes, or start a new work project, or finish another one I had at the back of my mind. I also get tons of ideas during weekends for cooking, or drawing or designing or just in general things I'd like to do, and I invariably forget them after a night out with friends. Which are absolutely worth it… but they make me crave monday morning the same as I crave banana muffins any other morning. There's an incredibly good feeling when you don't hit the snooze button and get to walk outside with the sunrise that carries on throughout the day, making those five days till friday actually really great. Almost as great as waking up to the smell of freshly baked muffins – which is what happens at my house when I don't get to work out because of a bad ankle. I just bake instead. In this case, greek yogurt, chocolate chip, oat and ultra banana-ish banana muffins. They're the perfect consistency, so smooshy from bananas you might even think there's no flour instead. And not overly sweet, which means you won't feel like you're having cake for breakfast. (on monday! Asolute no-no. That's ok on saturdays only) Not too much butter in them either, so have one after lunch as well. And since even sharing you can't possibly eat all 12 in one day, have some post-monday. Read more for the recipe!
Smaller is always better – Cinnamon brioche bites
Most bakers love bite-sized things. They're just irresistible to make. There's something about seeing a small army of pastries, all properly lined up on baking sheets waiting for their time in the oven. And when dressing, rolling, cutting or stuffing, there's a strange pleasure to be found in doing the same thing for each one of the small baked goods, trying to get them as even as possible. (Or maybe I'm slightly obsessive and find this satisfying…). But who can deny the appeal of a basket filled with bite-sized treats? No one. And I'll tell you why; if you had a basket of regular-sized croissants sitting on your breakfast table, the most you could grab in one sitting, without losing face in front of your breakfasting companions, is one lonely piece. And pushing it, you could eat half of this piece with one topping and the other with a different one. But if you have a basket full of mini-croissants… the possibilities are endless! Because no one will judge you if you spread nutella on one, take another one and smear some butter and marmalade on it, take a third one and dip it in your milk, or even if you take a fourth one to accompany a little bit of ham and cheese you had left over on your plate. That's the beauty of bite sized. Small pastries just keep telling you to eat them because they know they're so small that what could be the harm in just one more? And they're absolutely right. Such is the case with these fluffy, buttery, cinnamon stuffed mini-brioches. It's like just eating the center of a brioche-a-tete several times over. Because once you have one you will have to have a second one and quite possibly a third one. And that's ok. No one will judge you.
Read more for the recipe!
Continue reading


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Beef Roulades
31 Aug 2009
|Beef round steak
|1 1⁄2 Pound (1/2 Inch Thick)
|Bacon slices
|Diced celery
|3⁄4 Cup (12 tbs)
|Diced onion
|3⁄4 Cup (12 tbs)
|Diced green pepper
|1⁄2 Cup (8 tbs)
|Canned beef gravy
|10 Ounce
Cut steak into four serving pieces.
Place bacon slice on each piece of meat.
Mix celery, onion and green pepper; place about 1/2 cup mixture on each piece of meat.
Roll up meat; secure ends with wooden picks.
Wipe beef rolls with paper towels.
Place in crock pot.
Pour gravy evenly over steaks to thoroughly moisten.
Cover crock pot and cook on low setting for 8 to 10 hours.
Skim off fat before serving.
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Beef Roulades Recipe


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Published on Dec 12, 2013
REMIX Day 1-Building the Creative Capital
REMIX Day 1-Building the Creative Capital
Richard Gibbs, Director of Business Development, iCity
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PETS: MINI DACHSHUNDS AKC Reg 2 females Shots & wormed. 7 wks old. $450 each 717-543-6269More info Email a friend
DOGS: Australian Shepherd pup. ASCA. Red Tri. $700More info Email a friend
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PETS: FOX RED Labrador Retriever Puppies, AKC. 1st shots, vet checked, wormed. $600. 814-577-6033More info Email a friend
PET SERVICES AND SUPPLIES: We're Lion Country Supply, a local dog supply company in business since 1974. Lion Country Supply is an international catalog and internet supplier for dog and upland bird supplies.Request our FREE 84-page 40th Anniversary catalog, featuring over 2,800 ...More info Email a friend
DOGS: AKC registered white/yellow lab pups ready for loving homes. Mom is a fantastic family dog and excellent pheasant hunter. Pups are 8 weeks and have had first shots. Male and females available. All have good dispositions.More info Email a friend


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This may only be useful to fellow Canadians, but I was browsing through my wife's favourite store (Dollarama) one day and this item caught my eye as a possible solution to my paint storage issue:
I already have a paint cabinet built that has all my spray paints and Testors glass jars, but I needed somewhere to store my growing selection of Vallejo paints that would be allow me to see everything at a glance. Turns out this little lipstick organizer is a good fir for the Vallejo bottles.
I also did a test fit and the Testors 1/4 oz bottles fit these organizers like a glove:
Happy modelling.


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Archive for the 'Rhubarb' Category
How to Grow – Rhubarb
There probably isn't anything easier to grow than rhubarb. At least if you're lucky enough to be handed a clump in a bucket by a neighbor. Simply plant in a hole with the original soil level even to the new spot; water. If you're planting crowns, follow the directions on the package; basically, bud side [...]
April 19, 2011 Tags: backyard garden, garden planning, how to grow rhubarb, Other Recipes, planning a garden, rhubabr, zone 5 Posted in: How to Grow, Rhubarb 7 Comments


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2004 Mazda RX-8 Q&A
2004 Mazda RX-8 Question: oil checking
when cheking oil. condensation noted a white film around opening of oil cap and on dipstick - mikim
Answer 1
That's probably OK, try checking for the condensation when the engine hot right after a good run. I don't think you should see signs of water then. If you do, I'd want to check out the crankcase vintilation system to be sure it's clean and clear. I think the weather's been wet and cold in your parts so some condensation is fairly normal. If you see any signs of coolant, that's another story. - Superbob
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The car jerks when going from 1st to 2nd gear and when changing it from park to drive and reverse to drive. I had the transmission oil checked and it was fine.
Be sure to check your owner's manual and use the correct engine oil. Mazda does not recommend using synthetic oil in the RX-8's rotary engine.
my car is hard to start it take a long time to start it
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Learn how to hang a mirror easily with these simple steps. From finding wall studs to determining the perfect placement, watch this video to learn more.


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Movies' first look
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Bold acts in B'wood!
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Celebs' oops moment!
Katrina Kaif's Portfolio Pics
Divas in sheer ensembles


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Ever since actor Venkatesh's son Arjun Daggubati was recently spotted at the launch of Telugu remake of "OMG! Oh My God" titled "Gopala Gopala", there have been rumours that he will be playing the actor's son in the movie.
"Arjun will be playing Venkatesh's son the film. It's a cameo but the duo has a few scenes together and it's sure going to catch the attention of the audiences. It was the director's idea to cast Arjun, and Venkatesh didn't mind because he would be acting with him," a source from the film's unit told IANS.
Venkatesh will be reprising the role of Paresh Rawal from the original, while Shriya Saran will be seen playing his wife on screen.
Actor-politician Pawan Kalyan will be seen in the role of modern-day Lord Krishna, which was originally played Akshay Kumar.
The film, which is jointly produced by Suresh Productions and Sharath Marar, is being directed by Kishore Kumar Pardasany.
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Carpe Diem KC
- Other
- 1822 Main St, Kansas City, MO, 64108
Raspberry Pi U.S. Roadshow with Rob Bishop
Kauffman Foundation and Union Station
Friday, August 23, 2013 from 5:30 PM to 7:30 PM (CDT)
Rob Bishop helped to create Raspberry Pi®, a game-changing credit card-sized computer, and now he wants to serve it up to kids around the world to help them learn to program.
At an evening event hosted by the Kauffman Foundation and Union Station on Friday, Aug. 23, the Raspberry Pi engineer and evangelist will present "Raspberry Pi—One Year On." Bishop's talk will cover the origin of the product and company, highlight recent developments, provide technical information, and address the Raspberry Pi Foundation's educational aims. Time for an in-depth Q&A on Raspberry Pi educational and technical matters will follow.
Introduced in 2012 in the UK, the Raspberry Pi computer plugs into a TV and keyboard. The capable little PC, which sells for $35 or less, can be used much like a desktop PC for spreadsheets, word processing, games, and high-definition video.
Kauffman Foundation
The Ewing Marion Kauffman Foundation is a private, nonpartisan foundation that aims to foster economic independence by advancing educational achievement and entrepreneurial success. Founded by late entrepreneur and philanthropist Ewing Marion Kauffman, the Foundation is based in Kansas City, Mo., and has approximately $2 billion in assets. For more information, visit www.kauffman.org, and follow the Foundation on www.twitter.com/kauffmanfdn and www.facebook.com/kauffmanfdn
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11311 - Casa Strecce
from £125 /night help Price for guests, Nights
from £125 /night help Price for guests, Nights
Estimated nightly price based on a weekly stay. Excludes fees (if applicable). Enter your dates to see the total cost.
Apartment / 3 bedrooms / sleeps 5
Availability Your dates are available
Apartment / 3 bedrooms / sleeps 5
|Key Info
Please note these Check-in Day Requirements for this property: Jul 05 - Jul 11 : Saturday check-out required.; Jul 18 - Jul 25 : Saturday check-in required, Saturday check-out required.; Jul 26 - Aug 01 : Saturday check-out required.; Aug 08 - Aug 15 : Saturday check-in required, Saturday check-out required.; Oct 29 - Oct 31 : Thursday, Friday and Saturday check-out required.;
"Casa Strecce - App. 2", 4-room apartment on 2 levels, on the upper ground floor, practical and cosy furnishings: living room with open fireplace, satellite-TV and flat screen TV. Large kitchen-/living room (4 hotplates, oven, ceramic glass hob, electric coffee machine) with open fireplace. Exit to the terrace. Sep. WC. Electric heating. Upper floor: 1 double bedroom with 1 french bed (1 x 160 cm, length 200 cm). Exit to the balcony. 1 room with 1 double bed (2 x 90 cm, length 200 cm). 1 room, window onto the courtyard with 1 bed (90 cm, length 200 cm). Shower/bidet/WC. Wooden floors. Balcony, terrace. Terrace furniture, deck chairs (2). Partial view of the mountains. Facilities: washing machine, dryer. Please note: non-smokers only.Vergeletto 25 km from Locarno: Cosy, rustic, simple house "Casa Strecce", 3 storeys, semi-detached, renovated. 2 apartments in the property. In the resort, in a quiet, elevated position. Private: grounds, garden (not fenced). Heating payable locally. Narrow motor access to 50 m from the house. Stepped path (60 steps) to the house. Public parking 50 m on the road. Grocers 50 m, shopping centre 25 km, restaurant 100 m, bus stop "Vergeletto" 50 m, shingle beach "Fluss / Fiume RIBO" 500 m, indoor swimming pool 25 km, public bathing area 25 km. Riding stables 2 km, walking paths from the house 5 m, cable car 2 km, cross-country ski trail 2 km, ice rink 2 km. Well-known lakes can easily be reached: Lago Maggiore 25 km. Hiking paths: Valle Vergeletto. Please note: There are more similar properties for rent in this same residence.
|Sleeps up to 5, 3 bedrooms
|No pets allowed, No smoking at this property
Features and Facilities
|Log fire
|Washing machine
|3 bedrooms, 2 bathrooms of which 2 Family bathrooms
|Balcony or terrace
|Suitable for people with restricted mobility, Not suitable for wheelchair users
The Piedmont region
Cursolo Orasso
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You're booking with
Red Awning (Property Manager RedAwning)
- 1 Years listed
100% Response rate
Calendar last updated:05 Jul 2015
Based in United States
- English
Payment accepted
Credit cards accepted


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HN-HDR742 HM Digital
AquaPro TDS/Temperature MeterItem # HN-HDR742
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- Measures total dissolved solids (TDS) and temperature
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- Measurement ranges from 0-5000 ppm
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About Hydrofarm, Inc.Celebrated as the nation's oldest and largest manufacturer of hydroponic equipment and grow lights, Hydrofarm has made professional-grade equipment available to all since 1977. All grow lights and electric components are UL listed, unlike many competitor products, meaning you get years of reliable and safe use out your high-intensity lights. All products are covered by a one year warranty, at the least. In some cases Hydrofarm ensures the performance of their pr


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Drivers are facing a serious problem out here on the road.
On March 5, 2009 Jason Rivenburg was shot twice in the head and killed. He was a truck driver. He was parked at an abandoned gas station near Interstate 26 in South Carolina waiting to deliver his load, because the load's receiver wouldn't allow him to wait on their property.
On March 13, 2009 a driver was shot and injured in North Memphis when he stopped on an exit ramp to switch places with his co-driver. There are no truck stops or rest areas on that stretch of Interstate 240.
On February 22, 2008 truck driver Robert Earl Lee was fatally shot and robbed while trying to sleep in his truck. He had arrived early for his delivery in Tampa, FL and was told by the gate guard that he couldn't enter the property until 8:00 am. He had no choice but to park on the street. http://blogs.tampabay.com/breakingnews/2008/02/truck-driver-sh.html
On October 12, 1986 truck driver Robert Campbell was shot and robbed of $6 as he was taking his rest break at a rest area along Interstate 95. http://query.nytimes.com/gst/fullpage.html?res=9A0DE4DF123AF931A25753C1A960948260
Drivers are forced to park along streets, on highway ramps, and in empty lots due to a shortage of safe parking. At the same time several states are closing down their rest areas – most notably Virginia, but Vermont, New Hampshire, Arizona and California all have plans to close rest areas that provide valuable parking space for tired truckers.
Truckstops are filled to capacity and overflowing, forcing drivers to waste time circling the lot hoping for a space, then drive on down the road while tired to find a place to park.
Many shippers and receivers won't allow drivers to arrive early for appointments and require them to leave immediately after delivering – even if they are out of hours and can't legally drive.
The federal government, through the Safe Accountable Flexible Efficient Transportation Equity Act: A Legacy for Users (SAFTEA-LU), provides $6.25 million for states to provide rest areas and safe parking for commercial vehicles. This drop in the bucket has to be shared out between all 50 states, and is woefully inadequate. To give you an idea of where truck driver safety rates on the federal priority scale – the 2009 Omnibus spending bill included $6.6 million dollars for termite research. Apparently we rate just behind bugs.
Jason Rivenburg's family is working to raise awareness of this issue and they have built a website and started a petition asking lawmakers to work to improve the parking situation for truckers. Please visit their site and sign the petition for Jason's Law: http://www.jhlrivenburg.com/
Please write to your representatives in your state and the federal government and ask them to increase the funding for safe rest areas and to pass laws providing for safe places for truck drivers to rest while we are taking the breaks that federal law requires us to take.
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About Me
- Michelle
- I'm a 34 year old wife, truck driver, writer, and photographer with a love of adventure and travel. I am a Libertarian, and a total sci-fi geek. I studied archaeology at Auburn University.
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GPP Pop-Up Seattle: Why Go, and What to Expect - Several folks have asked for more specifics on the Seattle GPP Pop-Up. So here's the long version. Gulf Photo Plus is widely regarded as one of the best ...2 weeks ago
REAL Women in Trucking, Inc. Launches to Advocate for Urgently Needed Industry Changes while Supporting Female Truckers - *PALM BEACH GARDENS, Fla. (February 11, 2015)* - The promise of a fresh start and great pay draws thousands of people, including many women, to become truc...4 months ago
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All Karaoke Requests Here V2
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The Beginners Guide To The Site
Torrents That Need a Category Change - Post Here For Super Users & Translators To Move V2
It's Important To All UPLOADING On KAT........{A Must See}
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Happy Torrents Day 2015!
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Phishing on KaT and what you should do about it.
Need to throttle back
Account Security
The Truth Shall Set You Free!
A Night To Remember
Happy 239th, 'Merica
castle episodes
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the batu
raja rajendra kannada
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Le Dîner à San Francisco 2015
- Food & Drink
- San Francisco
VISION: Co-Creating Your Life in 2013
Dragonfly Healing Center
Saturday, January 19, 2013 from 1:00 PM to 5:30 PM (PST)
Dragonfly Healing Center was born out of a desire to help people from all walks of life reconnect with their inner light and find their soul's purpose through our many offerings of retreats and wellness services.
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Sub Magazin's Videos
280 Plays / 2 Likes / 3 Comments
The concept for this artwork evolved from an unbreakable bond between picture and sound. In his "classical" approach, the artist/VJ is drawing and following sound at the same time during…+ More details
KillingJazzHardCoreBaby - Platonic Lovers03:24
704 Plays / 1 Likes / 0 Comments
Spot za pjesmu "Platonic Lovers" travničke grupe KillingJazzHardCoreBaby.+ More details
Browse Videos
Here are all of the videos that Sub Magazin has uploaded to Vimeo. Appearances are videos that Sub Magazin has been credited in by others.