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Friday, 21 Mar 2014 09:22 AM
The outlook on the U.S.'s AAA credit-ranking was raised to stable from negative by Fitch Ratings after Congress suspended the nation's debt limit for more than a year, reducing the risk of a default, and as federal deficits decline.
The ratings company's adjustment follows Moody's Investors Service and Standard & Poor's, which raised their outlooks last year on the U.S. to stable from negative. S&P stripped America of its top grade in August 2011, citing, in part, political wrangling about the debt limit. Moody's gives the nation its top Aaa grade.
The issuer of the world's reserve currency avoided a downgrade as stronger growth is forecast by a government agency to reduce the budget deficit to a seven-year low as a share of the economy.
"While the mood in Washington is anything but collegial," there have been some signs of increased cooperation, Tony Crescenzi, executive vice president at Newport Beach, California-based Pacific Investment Management Co., said in an e-mail before the outlook change, citing lawmakers' agreement on budget outlays in 2014.
Market Reaction
Investors routinely ignore ratings companies' decisions. In almost half the instances, yields on government bonds fall when a rating action by Moody's and S&P suggests they should climb, or they increase even as a change signals a decline, according to data compiled by Bloomberg on 314 upgrades, downgrades and outlook changes going back as far as the 1970s. When S&P downgraded the U.S. government in August 2011, bonds rose and pushed Treasury yields down to records.
The benchmark 10-year Treasury note yield was little changed at 2.77 percent at 6:46 a.m. in New York, according to Bloomberg Bond Trader prices.
Fitch had warned since October that political disputes linked to the borrowing limit might spur a downgrade from AAA when it placed the country on Rating Watch Negative. The U.S. was assigned a negative outlook by Fitch in November 2011.
"The federal debt limit was suspended in mid-February in a timely manner and in a way that avoided casting uncertainty over the full faith and credit of the U.S., in contrast to the crises in August 2011 and October 2013," Fitch said in a statement.
The jointly-owned subsidiary of Paris-based Fimalac SA and New York-based Hearst Corp., Fitch is registered with the European Securities and Markets Authority, a regulator that oversees the industry. Fitch agreed to disclose a statement about the U.S. rating on March 21 as part of European rules.
Deficit Narrows
Congress suspended the debt limit until March 15, 2015, while income tax payments are projected to further postpone the date when the government may exhaust its borrowing authority.
At the same time, tax revenue needed to pay the government's bills is forecast to grow this year more than three times as fast as spending.
The U.S. fiscal 2014 deficit will narrow to $514 billion, or 3 percent of gross domestic product, from $680 billion last year, the Congressional Budget Office said Feb. 4. The projected gap is down from 9.8 percent of GDP in 2009, the widest in records dating back to 1974, and is close to the average of the past four decades, the agency said.
© Copyright 2015 Bloomberg News. All rights reserved.
Saturday, 04 Jul 2015 11:27 AM
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The graduation season is fast approaching. With each day that passes, anticipation grows of the gifts and money a graduate will receive in celebration of their achievement. It's crucial to plan ahead to maximize graduation cash before your young person dashes off to whatever lies ahead.
I was returning home late one evening last month on a United Airlines flight from Boston after attending a board meeting for the Campaign for a Commercial Free Childhood. The irony of this connection will be evident shortly.
At a recent workshop for prominent financial advisors in the Bay Area, we had a terrific discussion about the need/opportunity to rethink their current service models for multigenerational families – especially in light of the current economic environment.

subset: commoncrawl


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Ramston's latest sounds
General ambience recorded from the rooftop in Mumbai with nearby traffic, crows, alleyway people talking and general ambience of the ...
June 16th, 2015
5 downloads
0 comments
A field recording in Mumbai of a vegetable market while walking through it Rode ntg4 stereo mic
June 15th, 2015
10 downloads
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On board rode stereo mic of a camera, recording explosive ambush followed by ak47 shots and mortar bombs. Real recording ...
January 25th, 2015
345 downloads
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Opera singer singing "ABIDE WITH ME" recorded and mixed using multiple microphones with natural reverb of the church. Recorded using ...
January 22nd, 2015
307 downloads
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Recorded with an indirect view of a busy hub of pubs and clubs playing all arabic music. The soundscape is ...
January 22nd, 2015
328 downloads
3 comments
A walk in the Sunday Market with lots of people around selling all sort of stuff. Lots of People calling ...
January 22nd, 2015
184 downloads
1 comment
Zoom H4N close perspective recording of a daytime cricket with flies around and background of birds. Recorded in summer 2011 ...
January 22nd, 2015
118 downloads
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A recording of a prayer I have done in Sabra Palestenian camp area in Lebanon using a Zoom H4N. Quiet ...
January 21st, 2015
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A recording of a kids choir singing the lebanese national anthem. line level recording from the mixer board mixed with ...
December 1st, 2014
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A recording of a woman shouting as she is having fun using a sanken cs3e shotgun mic. Pure none edited. ...
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A stereo recording from the side view of the airplane at Beirut Airport taken from the runway Stereo Rode NT4 ...
November 20th, 2014
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Recording I have done using an Oktava Mk012 in a church. this has been mixed with an omni directional Lavalier ...
March 8th, 2013
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Morning birds in the city
May 31st, 2012
2199 downloads
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Spring Ambiance City Horizon Birds light traffic car Beirut
May 30th, 2012
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Shaken not stirred :) multiple shakes, single shakes, fast slow, pick up sound at the end. I needed that for ...
February 22nd, 2010
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Tag: Past
Kwanghee kissed someone in the past month? + regrets saying he wants to go to SM
Lie detector tests are always fun. On the April 4th episode of MBC"s "Infinity Challenge," the cast members found out that Kwanghee had kissed someone in the past month! . ... Read more
KARA"s Seungyeon talks about her past and future in acting with "BNT International"
KARA"s Seungyeon was recently featured in "BNT International" for a preppy, feminine photoshoot and intimate interview.
Seungyeon revealed that when she gets stressed, she talks to sunbaes SS501"s Park Jung Min and After School"s UEE. She said about Park Jung Min, "He"s like an unni, and we"re able to communicate well. He gives lots of advice too." About UEE, Seungyeon revealed, "She and I keep in touch sometimes, but especially when the other is hurt or negative comments are written about us online. That"s when we contact each other asking if we"re okay." . ... Read more
Hongki vents his frustrations regarding Han Sung Ho + talks about a past girlfriend and Yonghwa
F.T Island"s Hongki finally made his way back to MBC"s "Radio Star" on April 1 to air his grievances regarding comments made by FNC Entertainment"s Han Sung Ho last time. . ... Read more
"Unpretty Rapstar"s Yook Ji Dam reveals she was bullied in the past on "Taxi"
Former "Unpretty Rapstar" challenger Yook Ji Dam shared a difficult part of her past, receiving mixed feelings from the viewers
On the April 1st airing of tvN"s "Taxi", rap female icons Cheetah, Jessi, and Yook Ji Dam appeared on the show and talked about their personal life stories as well as how they became rappers in the first place. . ... Read more
Psy reveals new version of past track "Father" feat. Chinese pianist Lang Lang
Psy has revealed his music video for "Father" featuring Chinese pianist Lang Lang!
This version of "Father" is a remix of his past hit of the same name, which took on a more rock vibe. This new song also features Chinese lyrics and a slower beat, but like the Korean version, it"s a dedication to the fathers out there who sacrifice quietly for their families.. ... Read more
[Spoiler] "Angry Mom" Kim Hee-seon"s past to be revealed in relation to death of Kim Hee-won"s younger brother
On the March 25th episode of MBC"s Wednesday & Thursday drama, "Angry Mom", it showed what happened in the past between Jo Kang-ja (Kim Hee-seon) and Ahn Dong-chil (Kim Hee-won) through flashback scenes. . ... Read more
Super Junior"s Henry calls out Gong Seung Yeon"s past on "We Got Married"
'Heard it Through the Grapevine" Baek Ji Yeon And Yoo Joon Sang's Past Relationship
In "Heard it Through the Grapevine" the past relationship of Baek Ji Yeon and Yoo Joon Sang was drawn out as Yoo Ho Jung was annoyed by Yoo Joon Sang"s attitude.
On the 7th episode of SBS Monday/Tuesday drama "Heard it Through the Grapevine (script Jung Sung Joo, director Ahn Pan Suk) broadcast on Mar. 16th, Han Jung Ho (played by Yoo Joon Sang) met the husband of Ji Young Ra (played by Baek Ji Yeon) regarding an accounting audit issue. . ... Read more
Watch How Korean Beauty Has Changed Over The Past 100 Years In This 1-Minute Video
[Happy Together] g.o.d's Park Jun Hyung's Appearance was edited out of the television version in the past
As part of his grieving, g.o.d's Park Jun Hyun experienced disappointment and depression!
KBS 2TV's Happy Together3 recently recorded the 'Bromance Special' with some of the industry's representative bromance stars. The filming was attended by Kim Sung Joo and Seok Joo Il, who became friends through sports commentary, Park Jun Hyung and Danny Ahn, who are actually cousins, as well as Lee Gyu Han and Jo Dong Hyuk, who are unexpectedly close to each other.. ... Read more


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The Top 10 In Action Sports
01Brick By Brick: Camping Lego Style
02Booze and Bikes: 14 Tours That Let Combine Two of the Best Things in the World
03Who Needs Hollywood? These Incredible Videos Were All Filmed on the Simplest Cameras
04Sam Pilgrim vs. The World: The Champion Aiming To Reclaim His Crown In A New Era Of Biking
05Eccentric Adventures Episode 2: Britain's Most Brutal Illegal Event is All About Cheese
06A Journey Into Darkness: We Went Mountain Biking in the Abandoned Mines of Slovenia
07After the Apocalypse: Inside The World's Most Breathtaking Ghost Towns
08Debate: Let's Stop Hating On Parents Who Want To Raise Adventurous Kids
09Guns, Roses, And Eating Insects: Adventure Cycling in Vietnam
10From Intense Trails to Intensive Care: Dicing with Death In a Mountain Biking Paradise
Pixels Episode 2
A Skateboarding video by Pixels - 1,575 views
This episode features a good old fashioned jam at the brand spanking new Tredegar Park in Newport, Wales. The rain stayed away and the park was amazing! This is kind of a mini-episode due to staff holiday/skiving but we'll be back with a full-length episode next time.
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Human Resources
HR Department
Office: Admin 145
Phone: (406) 638-3148
Fax: (406) 638-3169
Home >> Human Resources
Human Resources
|Closing Date
|Financial Aid Assistant
|June 19, 2015
|Head Women's Basketball Coach
|Open Until Filled
|Hean Men's Basketball Coach
|Open Until Filled
Application Steps:
- Download the application packet from the link above.
- Fill out and mail or fax Forms and KSA's to:
Little Big Horn College
Attention: Human Resources Department
P.O. Box 370
Crow Agency, Montana 59022


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The Rev. Margo Peterson is the new pastor of St. Martin of Tours Lutheran Church in Mascoutah. She began serving at St. Martin's on June 1.
Peterson had previously served a one-year term as interim pastor to the congregation and recently accepted the congregation's call to be their spiritual leader.
Peterson hails from Milwaukee, Wis. She received a bacherlor of arts degree in Human Services from Judson College in Elgin, before attending the Lutheran School of Theology in Chicago, where she earned her Masters of Divinity degree. She was ordained Oct. 26, 2003. She has served congregations in Warren and Durand Ill., and Muscoda, Wis.
Peterson and her husband Jeff have three sons and live in Dittmer, Mo.
Peterson's passions are teaching and preaching.
"I love diving into the Scriptures with all age groups. It is great fun and truly fulfilling to help people have 'Aha!' moments when studying the Bible. In addition, I really enjoy leading prayer and meditation groups, enabling people to experience God in new and very personal ways.
"I think of preaching as conversation about the Scriptures for the day and how God is speaking to us through them. ... I don't preach from manuscript because I want to speak to and with the congregation, not at them."
Bishop S John Roth of the Central/Southern Illinois Synod of the Evangelical Lutheran Church in America will officially install Peterson at a 9 a.m. service on July 20. Members of the community are invited to attend the 9 a.m. installation and a reception that follows from 11 a.m. to 1 p.m.
St. Martin of Tours Lutheran Church is at 1190 N. Sixth St, in Mascoutah. Worship services are at 9 a.m. sundays, with fellowship and education following. After service pot lucks are held every second Sunday of the month from September through June.
Information: 618-566-2036 or email@example.com


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Security Services, Managed Services, Email ServicesProduct Subcategories:
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WHAT: Secure file sharing and collaboration in the cloud.
PRICE: $0/month (basic); $12.50/month (premium); $25/month per user (business).
Menlo Security Isolation Platform
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PRICE: $150 per user.
Kaspersky Security for Virtualization
VENDOR: Kaspersky Labs
WHAT: A suite of protection functions for VMware, Citrix and Microsoft virtualized environments.
PRICE: Depends on configuration.
Intigua Virtualized IT Operations Command Center
VENDOR: Intigua
WHAT: Virtualizes existing management tools using proprietary container technology to encapsulate them in their entirety, and enables them to be centrally managed and automated via a policy engine.
PRICE: Starts at $50,000 annual subscription.
Gurucul Risk Analytics
VENDOR: Gurucul
WHAT: Behavior-based machine learning and predictive analytics.
PRICE: $50,000 per year.
HyTrust DataControl
VENDOR: HyTrust
WHAT: Cloud security automation through encryption.
PRICE: Based on number of virtual machines and term of service – includes encryption and key server cluster for high availability.
5nine Software Cloud Security
VENDOR: 5nine Software
WHAT: Virtual system security, specifically for Hyper-V environments.
PRICE: $199 per two CPU per year.
Catbird Insight
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WHAT: Automatically and continuously discovers all assets in the virtual infrastructure, allows the grouping of these assets into logical Catbird Trust Zones.
PRICE: $25,000 up to 50 hosts.
BitDefender Gravity Zone
VENDOR: Bitdefender LLC
WHAT: Centralizes and de-duplicates security tools, such as anti-malware, in a virtual environment.
PRICE: $1,015 (one year protection for 10 virtual servers).
PrivateCore vCage
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WHAT: Secures servers with software-based attestation, full-memory encryption and OS hardening, providing a foundation for trusted computing.
PRICE: $1,000/month for up to 20 servers for vCage Manager.
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SC Magazine Articles
- 'MEDJACK' tactic allows cyber criminals to enter healthcare networks undetected
- Samsung devices, including Galaxy S6, vulnerable to remote code execution
- Dridex banking malware spreading through new spam campaign
- More than 440K new Android malware strains found in Q1, study finds
- U.S., China agree to cybersecurity code of conduct
- Former Georgia-Pacific sysadmin charged with damaging protected computers
- Harvard University announces network intrusion, possible data exposure
- Saboteurs leverage RIPv1 for DDoS reflection attacks
- More than 440K new Android malware strains found in Q1, study finds
- Apple releases OS X 10.10.4 and iOS 8.4, numerous bugs addressed


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Cents-ible ways to save in the Capital Region
Monthly Archive for December, 2013
New buy two, get one free DiGiorno pizza coupon
There's a new high-value buy two, get one free DiGiorno pizza coupon to print. You can stack this manufacturer coupon with the current Price Chopper store coupon (good through Tuesday) that will save you an additional $2 off the purchase of two pizzas. Here's how it works: Buy 3 DiGiorno Pizzas: $5 Use: Buy two, […] [Read More]
Best grocery store deals (ShopRite, Price Chopper, Hannaford) Dec. 29-Jan. 4
I'm off through early January so my regular coupon matchups are scaled back, quite a bit. So, here is a roundup of some of this week's best grocery store deals: Hannaford: Cabo Authentic Guacamole: $3.49 Use: $3/1 Cabo Authentic Guacamole Final cost: $.49 Koyo Ramen Noodles: $1.19 Use: $1/1 Koyo Ramen Noodles Final cost: $.19 […] [Read More]
Price Chopper bonus printable coupons and new store eCoupons
Heading to Price Chopper? Be sure to click and print these bonus coupons. Some are good through Dec. 31 while other expires Jan. 4. Side note: Head to Google Offers and load the Save $1/2 Tostitos and/or Lay's Potato Chips coupons to your AdvantEdge Card to save even more. Price Chopper has also posted several […] [Read More]
Kindle magazines for $5
If you received a new Kindle for Christmas or want to update your current device's content for a few bucks, Amazon is now offering a severl of digital magazines for just $5. Among the titles included in this promotion are Ladies Home Journal, Parents Magazine and Allrecipes. Click here to see the selection. You can […] [Read More]
And the winner is… Share your money-saving New Year's resolution, win a $25 gift card
Thank you to everyone who shared their money-saving resolution for the New Year. They are inspiring and I wish you all the best in 2014! The winner of the $25 Hannaford gift card, selected at random, is @Pam. Congratulations! I hope everyone had a Merry Christmas. Now that it's over, it's time to look ahead […] [Read More]
After Christmas sales: Macy's, Kohl's, Pottery Barn, Target and more
I don't know about you, but this shopportunist is shopped-out, believe it or not. That said, there are some great post-Christmas sales, so if you're looking for bargains or have gift cards to cash in, here are some fine offers: Ballard Designs: 15% off all furniture and upholstery. Barnes and Noble: In-store clearance, items with […] [Read More]
Merry Christmas!
I just wanted to post a quick note to wish everyone a very Merry Christmas. I hope your shopping prowess paid off and you're surrounded by love this holiday season. [Read More]
Show More


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Welcome to my Christmas in July Sale !
Uniquely Distinctive, One-Of-A-Kind, Vibrant Orange Boro Glass Lampwork Heart Focal, Swarovski Crystal, Vermeil, Wearable Art Necklace.
This STUNNINGLY VIBRANT Necklace features a Vibrant Orange Boro Glass heart focal .... the Heart Focal is handcrafted, and properly kiln annealed - created by a Glass Lampwork Artisan in Oregon. Substantial in size, the Heart Focal measures 1 1/4 Inch in Width x 1 3/4 Inches Tall x 5/8 Inches Deep. The Heart additionally has Subtle Swirling Wisps of Yellow (that did not fully photograph) which accordingly picks up the Yellows in the Flashing Fire Opal Swarovski Crystal Beads ... The Necklace portion is comprised of Dazzling 8 mm Facet Cut Orange Fire Opal Swarovski Crystals, nestled between Vermeil Bead Caps, and separated with 4 mm Orange Fire Opal Swarovski Crystals. (Fire Opal Swarovski Crystal is named due to its subtle & vibrant flashes of Red & Yellow ... a similar characteristic to the way in which a natural opal flashes different colors). This Necklace is Fluidly finished with a Vermeil Toggle Clasp.
This One-Of-A-Kind Necklace measures 18 Inches in Length.
** NOTE ** Vermeil (pronounced ver-may) is a combination of precious metals. Vermeil is Carat Gold over Sterling Silver, and I use high quality 22K Gold Vermeil in my creations.
If you are new to Glass Lampwork Art, each bead is Individually hand crafted by heating solid glass rods to a molten state - Depending on the skill of the Glass Lampwork Artisan, the end result can be phenomenal ! Lampworking involves carefully manipulating hot molten glass ... and no paint or painting is involved !
Another shopper has this item in their Cart or Wish List.
"Handcrafted One-Of-A-Kind Jewelry & Wearable Art, Designed To Be As Unique As You Are."
Uniquely Distinctive, One-Of-A-Kind Jewelry Creations & Wearable Art ... HUGE CHRISTMAS IN JULY SALE !!
|Shipping/Handling :
Price for shipping to USA change location
USPS First-Class Mail Parcel


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- //Home
- //Music
- //Reviews
- //Saint Rich
Saint Rich
Beyond the Drone
US: 30 Sep 2013
UK: 30 Sep 2013
To read about the origins of Saint Rich is to feel like you're reading about a side project. Christian Peslak and Steve Marion played together in Marion's project, Delicate Steve. On a break from tour, the two began working on material that didn't seem to fit the Delicate Steve feel. Marion swapped out a guitar for drums, Peslak strummed out some chords, and Saint Rich was born.
The duo banged out seven songs pretty quickly, and from there developed Beyond the Drone, the debut album out now on Merge. To listen to this, though, there's little side-project reticence or tossed-off relaxation about the album. This is a focused, intricate set, one that fittingly has been done for a year and is now seeing daylight. That sense of taking your time, of taking the long way home, informs this record on many levels.
Marion, the main force behind Delicate Steve, shaped these songs melodically, but he yields to Peslak's honeyed voice and curious guitar phrasings to front the show here. Together the pair mesh well Americana's dust with power-pop's glitter, and the dingy shine they create is solid. Those musical touchstones, though, don't create opportunity for Saint Rich to steep itself in tradition. Instead, they are springboards to the strange twists and structural shifts that can make these songs, at their best, surprising and resonant.
Early standout "Officer" shows off Peslak's pipes immediately, as well as the clear link between his shearing guitar riffs and Marion's off-kilter yet in-the-cut drumming. The song chugs along on angular hooks and steady percussion, but things shift unexpectedly when it opens up into a thick shimmer of sound, with keyboards, guitars, and drums soaring in step with each other. It's a move that feels both inevitable in its sound but wholly out of left field in its delivery. Similarly, "Sorry/Sadly" starts with a sun-baked desert thump but then bottom's out into space and re-emerges as a churning swell, injecting that thump with an urgent sweat.
Other shifts and eccentricities are delivered more slyly. Jangling electric guitar punctures holes into the strum of "Dreams". "Black and Brown" turns the sunburst elements of these other songs on their ear, turning the crunchy guitars into something more sneering. Most memorably, "You Ain't Worth the Night" takes classic rock hooks and lets them tumble down into the spaces of Marion's skittering drums. In these songs, we see the band's own personality rise up through the structures rather than imposing it on them after the fact. These songs are sun bright, to be sure, but they never forget the stand of clouds in the distance. There's a darkness just under the surface. Sometimes, as on "Coming Home", the band leans too heavily on the bright and song sounds too thin as a result, where more subtle moments like the pastoral folk of "Don't Bring Me Down" sneaks its long shadow in effectively.
The twists in structure and songcraft here are so effective that other moments of more shapeless experimentation feel a bit limp in comparison. The album opens with a titular sonic introduction, a squall of feedback and transmitted voices that feels a bit too self-serious to set up the playful record that comes. Similarly, the excellently epic closer "Already Gone" is done no favors by being set up by another noise piece on "To the Sun".
These slight missteps don't sap the album of its charm, however. And, on Beyond the Drone, an album that seems to be digging thematically into the space between fruitful wandering and aimless drifting, setting a toe off the path once in a while is inevitable. Still, this is a solid and convincing first record from Saint Rich, proof that there's plenty of places they go, but also that they've already come a long way quickly.
- "Officer" Soundcloud
The Dolomites "Wakannai" (video) (premiere) // Music
A Crooked and Unseen Highway: lowercase - "You're a King"
// Sound Affects
"Like too many great bands, Lowercase have never received their full due. Ragged, deeply, sometimes even awkwardly, personal music like theirs typically becomes the property of small but passionate fanbases.READ the article


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Videos tagged "maori"
213K Plays / 1,674 Likes / 57 Comments
Shot this Haka performance on a recent jaunt to NZ with O'Neill for the 24 minute show and I thought I'd put it up here in its entirety. Scary fellas.+ More details
Road-Trip in New-Zealand (5DMK3 RAW)02:50
8,697 Plays / 156 Likes / 49 Comments
This country is amazing. The people there are nice and full of generosity. I really spent 2 weeks contemplating the stars, sky, landscapes and meeting the Maori people was a lifetime experience. I was followed by my friends Robin and Steph Killip in this great adventure ! Thank you for making me discover this amazing part of the world. Follow me: www.facebook.com/pascaldelefilmaker website: www.pascaldelefilmaker.com www.lifestyleprod.fr www.objectif-cineaste.fr Camera: Canon 5D Mark3 + ML RAW Lense: Canon 100mm Canon 24 mm f/1,4, Zeiss 85 mm f/1,4 50 mm f/1,4 editing: Magicraw+Lightroom+Dresolve+fcpx music: TimeScapes Trailer 2/ John Stanford Please donwload in itunes store+ More details
8,344 Plays / 84 Likes / 33 Comments
Deep in the Urewera Ranges, Māori elder Beam Titoko puts on his best cowboy hat, digs out his old guitar and sings a song of home. Made by Tūhoe filmmakers, this affectionate portrait of a community pays tribute to the strength of the families who keep Tūhoe's home-fires burning. Director/Producer: Tim Worrall and Aaron Smart Loading Docs is a series of 10 incredible 3-minute documentaries from New Zealand. Watch them all, like and share! https://vimeo.com/channels/loadingdocs www.loadingdocs.net+ More details
ITV Rugby World Cup Title Sequence 201101:01
13.3K Plays / 377 Likes / 27 Comments
Opening title sequence for ITV1's coverage of the 2011 Rugby World Cup by Jump Design and Direction. www.jumpdesign.co.uk The sequence is based around images created in ink - a reference to the native maori tattoos of New Zealand where the tournament is being held. Agency - Jump Design & Direction Design & Art Direction - Lee Jacobs Compositing - Russell Mann Particle Simulations - Phil Webster and Play Nicely http://vimeo.com/29094923 Directors - Richard Norley, John McKenna 3D Studio, Fume FX, Krakatoa, Cinema 4D, After Effects+ More details
6,450 Plays / 67 Likes / 18 Comments
Hi, this is a short version of an 90 minute film I shot when I visited beautiful New Zealand last year. Camera: Canon 5d Mark II Lenses: 17-40 4L, 24-105 4L, 100 2.8 macro, 100-400 4.5-5.6L Accessories: Manfrotto tripod, Fader ND Edited in Sony Vegas Pro 10+ More details
A man's life long struggle to battle his demons.+ More details
11.4K Plays / 51 Likes / 10 Comments
vidéo à l'arrache d'un trip photo en compagnie de Maël & Alan l'helgouac'h, Thomas "jonkette" Joncour et Martin viezzer+ More details
1,116 Plays / 24 Likes / 7 Comments
Composer - Phillip Wareborn Sound Design - Mitchell Hampton Thanks to my teachers, family and friends! I couldn't have done this without everyone's support. Enjoy!+ More details
20101016 Rotorua Weekend Getaway Activities 4min04:22
43 Plays / 1 Likes / 6 Comments
Maori welcome at Tamaki Brothers Village in Rotorua. Cruise on Lakeland Queen on Lake Rotorua. Freefall extreme in Agrodome Agroventures. Shweeb ride in Agrodome Agroventures. The Squeeze in Orakei Korako just off Waikato River. Hot pools.+ More details
ISLAND TAT Commercial Spots (:30 :15 :15 :60)02:00
560 Plays / 5 Likes / 6 Comments
http://IslandTat.com/ Commercial spots currently on-air on Hawaii NBC and Fox affiliates. Director Jennifer Akana Sturla. Nathan Trasoras, Tiana Liufau, D.Masi, Tadao Salima, Po'o Atay. EP Josh Elsas. Prod. Tadao Salima and Jennifer Akana Sturla. DP Michael Fimognari. Choreography Nathan Trasoras and Tiana Liufau. Broadcast spots' music written and performed by Datboy's Logic & Prod. by Breadman of Bread Box Beats. VFX and online editing by Comen VFX. http://IslandTat.com/+ More details
What are Tags?
Tags are keywords that describe videos. For example, a video of your Hawaiian vacation might be tagged with "Hawaii," "beach," "surfing," and "sunburn."


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Fax: +81-11-706-7899
Cancer Cell Biology
Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: Its relevance in cell motility and invasion
Article first published online: 16 JUN 2001
DOI: 10.1002/ijc.1410
Copyright © 2001 Wiley-Liss, Inc.
International Journal of Cancer
Volume 93, Issue 6, pages 786–791, 15 September 2001
Additional Information
How to Cite
Hiroumi, H., Dosaka-Akita, H., Yoshida, K., Shindoh, M., Ohbuchi, T., Fujinaga, K. and Nishimura, M. (2001), Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: Its relevance in cell motility and invasion. Int. J. Cancer, 93: 786–791. doi: 10.1002/ijc.1410
Publication History
- Issue published online: 13 AUG 2001
- Article first published online: 16 JUN 2001
- Manuscript Accepted: 12 APR 2001
- Manuscript Revised: 28 MAR 2001
- Manuscript Received: 4 JAN 2001
- Abstract
- Article
- References
- Cited By
- Ets-1;
- uPA;
- non-small-cell lung cancer;
- cell motility and invasion
Cell invasion and metastasis characterize the malignant potential of non-small-cell lung cancers (NSCLCs). We have previously reported that E1AF, a member of the Ets-related transcription factor family, confers invasive phenotype on breast cancer and oral squamous-cell carcinoma cell lines. In our study, we analyzed the E1AF expression in cell lines and resected tumors of NSCLCs by Northern blot and in situ hybridization analyses and found that 15 of 17 cell lines and 12 of 19 tumors expressed E1AF mRNA while normal lung tissue and concomitant normal cells within tumors did not. To examine the biologic importance of E1AF in NSCLCs, we introduced the E1AF gene into VMRC-LCD and NCI-H226, NSCLC cell lines lacking E1AF expression, and examined cell motility and invasion activities. E1AF-transfected VMRC-LCD cells showed increased cell motility that was 2-fold that of parental and vector-transfected control cells (p < 0.01), and both cell motility and invasion were increased 1.6-fold in NCI-H226 (p < 0.01). Furthermore, hepatocyte growth factor (HGF), which is one of the most effective cell-scattering factors, stimulated the motile and invasive activities in E1AF-transfected VMRC-LCD and NCI-H226 cells but not in their parental or vector-transfected control cells. Ets-1 mRNA expression was found in E1AF-transfected VMRC-LCD cells but not in parental or vector-transfected cells. HGF further induced expression of the Ets-1 and urokinase-type plasminogen activator (uPA) genes specifically in E1AF-transfected cells. These findings suggest that E1AF plays a substantial role in the cell motility and invasion of NSCLCs. © 2001 Wiley-Liss, Inc.
Lung cancer is one of the leading causes of cancer death throughout the world. Non-small-cell lung cancers (NSCLCs) are characterized by local tumor aggressiveness and a marked propensity for dissemination to regional lymph nodes as well as distant metastasis.1 The clinical observations that patients having NSCLCs in comparable stages may run different clinical courses and may respond differently to similar treatments have yet to be fully understood. Clearly, a more sophisticated understanding of the pathogenesis and biology of these tumors could provide useful information.
The Ets-related oncoprotein family has a highly conserved ETS-domain and works as a transcription factor. V-ets of avian leukosis virus E26 was the first one described,2, 3 and more than 30 Ets-related oncogenes have been isolated. They play important roles in the regulation of gene expression during a variety of biological processes, including cell growth, oncogenesis and developmental programs in many organisms.4
E1AF, which binds to the enhancer elements of the adenovirus type 5 E1A gene,5 is a human member of the Ets-related oncoprotein family.6, 7 The E1AF Ets-domain is identical to that of mouse PEA3 (polyoma-virus enhancer activator 3)8 and there was about 94% identity in amino acids between them,6 indicating that E1AF is a human homologue of mouse PEA3. We have previously reported that E1AF can upregulate transcription from different subclasses of matrix metalloproteinase (MMP) genes in transient expression assays,9 that E1AF confers the invasive phenotype in MCF7, a human breast cancer cell line,10 and that E1AF expression is correlated with the transcription of MMPs and the invasive phenotype in oral squamous-cell carcinoma cell lines.11 However, little is known about the importance of Ets-related oncoproteins, including E1AF, in the invasion and metastasis of NSCLCs.12
Previous studies have indicated that transactivation activity of E1AF is regulated by the mitogen-activated protein (MAP)-kinase signaling pathway,13 which is activated by the hepatocyte growth factor (HGF)-Met signals.14, 15 Therefore, the function of E1AF may be regulated by the HGF-Met signals. It has been established that aberrant HGF-Met signaling plays a critical role in the migration and invasion of cancer cells.16, 17 Moreover, increased expression of Met and/or HGF has been demonstrated in a variety of human cancers, including NSCLCs, and is often associated with increased tumor grade and poor prognosis.18–20 However, the mechanisms by which the HGF-Met signals promote invasive and metastatic activities as well as the molecular changes that activate invasion-associated matrix-degrading proteases in cancers are still largely unknown.
In our study, we examined E1AF expression in resected NSCLCs as well as NSCLC cell lines. Furthermore, we investigated the biologic importance of E1AF and its association with the HGF-Met signals in NSCLCs using E1AF-transfected NSCLC cell lines.
NSCLC cell lines and tumor specimens
Seventeen human NSCLC cell lines were cultured in RPMI 1640 supplemented with 10% FCS and 0.03% glutamine at 37°C in an atmosphere 5% CO2. They included 6 adenocarcinoma (A549, ABC-1, VMRC-LCD, RERF-LC-OK, RERF-LC-MS and PC-3) and 11 squamous-cell carcinoma cell lines (EBC-1, LC-1 sq, VMRC-LCP, LK-2, PC-10, NCI-H157, NCI-H226, NCI-H520, NCI-H1264, NCI-H1373 and NCI-H1703). All of the adenocarcinoma cell lines and 5 squamous-cell carcinoma cell lines (EBC-1, LC-1 sq, VMRC-LCP, LK-2 and PC-10) were obtained from the Health Science Research Resources Bank of Japan (Osaka, Japan), and 6 squamous-cell carcinoma cell lines (NCI-H157, NCI-H226, NCI-H520, NCI-H1264, NCI-H1373 and NCI-H1703) were kindly provided by Dr. H. Oie of the NCI-Navy Medical Oncology Branch, National Cancer Institute (Bethesda, MD).
Tumor specimens from 19 patients with NSCLC were obtained by surgery at the Minami-ichijo Hospital during 1997 and 1998. None of the patients were subjected to either chemotherapy or irradiation before surgery. According to the 1981 WHO classification,21 tumor specimens were histopathologically diagnosed as adenocarcinoma (n = 16), squamous-cell carcinoma (n = 2) and large-cell carcinoma (n = 1). The postsurgical pathologic TNM stage (pTNM) was determined according to the guidelines of the American Joint Committee on Cancer.22 The tumor specimens represented 9 stage I, 3 stage II and 6 stage III tumors, as well as 1 stage IV tumor.
Northern blot analysis
Total cellular RNA was prepared from cells or tissues by guanidine isothiocyanate lysis and subsequent CsCl gradient ultracentrifugation (Beckman, Fullerton, CA).23 For Northern blot analysis, total cellular RNA (10 μg) was electrophoresed through denaturing formaldehyde-containing gels24 and transferred to nylon membranes (Pall BioSupport, Glen Cove, NY). Hybridization of the nylon membranes with [α-32P]dCTP (ICN Biomedicals, Irvine, CA) random-primed E1AF, Ets-1, MMP-1, MMP-3, MMP-9, urokinase-type plasminogen kinase (uPA), uPAR, c-Met or cardiac actin cDNA fragments was performed by standard methods.23 Human cDNA probes were obtained from the following sources: E1AF (0.6 kb XbaI/BamHI fragment of pCMVETS), Ets-1 (1.45 kb HindIII fragment of Ets-1 cDNA; a kind gift from Dr. H. Suzuki, Hokkaido University, Sapporo, Japan), MMP-1 (1.7 kb EcoRI fragment of pUC19MMP-1), MMP-3 (a kind gift from Dr. M. Seiki, Kanazawa University, Kanazawa, Japan), MMP-9 (1.2 kb PstI/EcoRI fragment of pUC19MMP-9), uPA (1.5 kb PstI fragment of pEMBL8uPA; ATCC, Rockville, MD), uPAR (1.0 kb EcoRI fragment of pSG5uPAR; ATCC), cardiac actin (a kind gift from Dr. F. Gunning, Stanford University and Veterans Affairs Medical Center, Palo Alto, CA). Autoradiography was done on Kodak XAR-5 film at −70°C with an intensifying screen.
In situ hybridization
Tissue samples for in situ hybridization were obtained from 19 resected NSCLCs and fixed in 4% (w/v) paraformaldehyde at 4°C for 48 hr after surgical resection, followed by embedding in paraffin. In situ hybridization was performed as described previously.11 In brief, 5 μm-thick paraffin-embedded specimens were cut, mounted on 3-aminopropyl triethoxysilane-coated glass microscope slides (APC-coated glass slides; Matsunami, Kishiwada, Japan) and deparaffinized with xylene. They were then digested in a solution containing 0.1% pepsin in 0.1 N HCl at room temperature for 10 min. After acetylation (0.1 mol/L triethanolamine, 0.25% acetic anhydride), tissue slides were covered with an in situ hybridization mixture and a biotin-labeled RNA probe. The biotin-labeled RNA probe was synthesized by in vitro transcription of the linearized double-stranded DNA template of a 472 bp E1AF fragment (924–1396),11 using biotin-UTP for the sense and antisense strands with T3 and T7 RNA polymerases, respectively. Hybridization was carried out at 50°C for 36 hr. After hybridization, RNAse digestion and high-stringency washing were undertaken. Tissue slides were then stained with a GenPoint system (DAKO JAPAN, Kyoto, Japan), followed by counterstaining with methyl green.
VMRC-LCD and NCI-H226 cells were cotransfected with the E1AF-expression vector pCMVE1AF6 (2.5 μg) plus pRSVneo (0.125 μg) or the empty vector pEV3S25 (2.5 μg) plus pRSVneo (0.125 μg) by the standard DNA-calcium phosphate coprecipitation method. Transfected cells were selected for resistance to active Geneticin® (G418; Boehringer Mannheim, Indianapolis, IN) at 0.2 mg/ml. E1AF gene expression was confirmed by Northern blot analysis as described above.
In vitro motility and invasion assays
Transwell® cell culture chambers (pore size 8 μm; Costar, Cambridge, MA) were used for the motility and invasion assays. For the motility assay, cells (1 × 105 for VMRC-LCD and 2 × 104 for NCI-H226) were suspended in serum-free RPMI 1640 with 0.1% BSA (Sigma Chemical, St. Louis, MO) and added to the upper chamber. The reverse side of the upper chamber's filter was coated with human cellular fibronectin (10 μg)(Biomedical Technologies, Stoughton, MA) as a chemoattractant. Serum-free RPMI 1640 with 0.1% BSA with or without 20 ng/ml HGF (Toyobo, Osaka, Japan) (600 μl) was added to the lower chamber. For the invasion assay, cells (2 × 105 for VMRC-LCD and 1 × 105 for NCI-H226) were suspended in serum-free RPMI 1640 with 0.1% BSA and added to the upper chamber. The upper chamber's filter was coated with mouse Matrigel® (10 mg) (Becton Dickinson Labware, Franklin Lakes, NJ), and the reverse side of the filter with human cellular fibronectin (10 μg) as a chemoattractant. Serum-free RPMI 1640 with 0.1% BSA with or without 20 ng/ml HGF (600 μl) was added to the lower chamber. Cells were incubated for 24 hr at 37°C in a CO2 incubator. At the end of the incubation, cells on the upper surface of the filter were completely removed by wiping with a cotton swab. Cells were fixed in phosphate-buffered saline containing 3.7% formaldehyde and stained with Giemsa solution. Cells that moved into or invaded the lower surface of the filter were counted under a light microscope at a magnification of 200×. Each assay was performed in triplicate and repeated 3 times.
Expression of the E1AF gene in NSCLC cell lines and resected NSCLCs
We examined expression of the E1AF gene in 6 lung adenocarcinoma cell lines, 11 squamous-cell carcinoma cell lines and 19 resected NSCLCs. Northern blot analysis indicated that 2.5 kb E1AF mRNA was present in 5 of the 6 adenocarcinoma cell lines (the exception was VMRC-LCD) and in 10 of the 11 squamous-cell carcinoma cell lines (the exception was NCI-H226) but not in normal lung tissue (Fig. 1). Twelve of the 19 NSCLCs, including 11 of 16 adenocarcinomas, 1 of 2 squamous-cell carcinomas and none of 1 large-cell carcinoma, and 8 of 9 stage I, all 3 stage II, 2 of 6 stage III and none of 1 stage IV tumors expressed E1AF mRNA, although normal lung tissue again did not express E1AF mRNA (Fig. 2).
In situ hybridization in resected NSCLC tissues
We performed in situ hybridization analysis for E1AF expression in resected NSCLCs to examine its expression in tumor cells and concomitant normal cells separately, using E1AF antisense RNA as a probe. Cytoplasmic hybridized signals of E1AF were seen in cancer cells but not in concomitant interstitial cells in all 12 NSCLCs examined (Fig. 3a), which showed E1AF expression in Northern blot analysis, while no such signals were observed in either cancer or concomitant interstitial cells in NSCLCs that did not show E1AF expression in Northern blot analysis (data not shown). In addition, in situ hybridization analysis, using E1AF sense RNA as a probe, did not show any signals for the same specimens.
In vitro motility and invasion activities of E1AF-transfectants
We next studied the biologic importance of E1AF expression in NSCLCs by analyzing motile and invasive activities of E1AF transfectants in vitro, using Transwell® cell culture chambers. VMRC-LCD is an adenocarcinoma cell line of the lung not having E1AF expression (Figs. 1 and 4, lane 1). VMRC-LCD cells transfected with E1AF showed a high level of E1AF expression (Fig. 4, lane 3). E1AF-transfected VMRC-LCD cells exhibited increased cell motility compared to both parental and vector-transfected cells (p < 0.01) (Fig. 5a), while cell invasion activity did not differ much between before and after E1AF transfection in this cell line (Fig. 5b). Then we studied motile and invasive activities with 20 ng/ml of HGF, since this VRMC-LCD showed a high level of met mRNA by Northern blot analysis (data not shown), and the HGF-Met signals have been shown to be involved in the cell motility and invasion.16, 17 HGF stimulated neither motile nor invasive activity in either parental or vector-transfected VMRC-LCD cells. In contrast, both motile and invasive activities were increased with HGF treatment in E1AF-transfected VMRC-LCD cells compared to those without HGF treatment (p < 0.01) (Fig. 5a,b). In addition, we analyzed motile and invasive activities of the E1AF transfectant of a squamous-cell carcinoma cell line of the lung, NCI-H226, which lacked E1AF expression (Figs. 1 and 4, lane 4) and had met expression (data not shown). E1AF-transfected NCI-H226 cells showed a high level of E1AF expression (Fig. 4, lane 6) and exhibited increased cell motile and invasive activities with or without HGF treatment compared to both parental and vector-transfected cells (p < 0.01) (Fig. 6a,b). These results indicated that E1AF activated cell motility and invasion in NSCLCs and that E1AF had a substantial role for the activation of cell motility and invasion with or without the HGF-Met signals. In addition, met expression was analyzed by Northern blot analysis in 12 NSCLC cell lines, and no correlation was found between met and E1AF expression; 7 of 10 E1AF-positive cell lines and both E1AF-negative cell lines showed met expression (data not shown).
HGF induces expression of Ets-1 and uPA mRNA in E1AF-transfected VMRC-LCD
To elucidate how E1AF enhances invasiveness, we examined expression of several molecules potentially involved in the invasion and metastasis in E1AF-transfected VMRC-LCD cells. Expression of Ets-1 (6.8 and 2.7 kb mRNAs) was detected even before HGF treatment, and both Ets-1 mRNAs proportionally increased 3 hr after the addition of HGF in E1AF-transfected cells (Fig. 7). But Ets-1 expression was not detectable either before or after HGF treatment in parental or vector-transfected cells. Furthermore, the expression of uPA mRNA was increased 3 hr after the addition of HGF in E1AF-transfected VMRC-LCD cells. In contrast, no such increase of uPA expression was seen in parental or vector-transfected cells. The mRNA encoding for uPAR was expressed at a low level and no increase was seen after the addition of HGF in parental, vector-transfected or E1AF-transfected VMRC-LCDs (data not shown). The mRNAs for MMP-1, MMP-3 and MMP-9 were not detectable either before or after HGF treatment in any of these 3 VMRC-LCDs (data not shown).
In our study, we showed that cell lines and resected tumors of NSCLCs expressed E1AF mRNA frequently, while normal lung tissue and concomitant normal cells in tumors did not express E1AF by Northern blot and in situ hybridization analyses. These data suggest that E1AF may play an important role in NSCLCs. To determine the role of E1AF expression in NSCLCs, we transfected an E1AF expression vector into NSCLC cell lines that did not express E1AF mRNA. In vitro motility assay revealed that motile activity increased significantly in E1AF-transfected NSCLC cells. In the presence of HGF, both motile and invasion activities increased significantly in E1AF-transfected NSCLC cells compared to in the absence of HGF, but no such increase was detected in either parental or vector-transfected cells. Northern blot analysis indicated that E1AF-transfected VMRC-LCD expressed Ets-1 mRNA, which was not expressed in either parental or vector-transfected VMRC-LCDs, and that 3 hr after the addition of HGF, Ets-1 and uPA mRNAs increased in E1AF-transfected VMRC-LCD but again no such increase was seen in either parental or vector-transfected VMRC-LCDs, suggesting that Ets-1 and uPA were involved in the motile and invasive activities of E1AF-expressing NSCLCs through the HGF-Met signaling pathway. We previously showed that Ets-1 but not E1AF activated the promoter of uPA in breast cancer.26 In addition, Fafeur et al.27 reported that HGF stimulated Ets-1 expression, which resulted in uPA expression and the cell dispersion in MDCK epithelial cells. Consistently, it has been shown that HGF stimulation of a variety of cells expressing Met induces uPA expression28, 29 through a pathway involving MAP kinase signaling.14, 15 Taken together, it is indicated that HGF-induced Ets-1 activates the transcription of the uPA gene in the E1AF-transfected VMRC-LCD, in which basal expression level of Ets-1 is upregulated by E1AF. This is the first study that has shown that E1AF can induce Ets-1 expression, although the effect of E1AF expression on the promoter activity of the Ets-1 and uPA genes was not examined in our study. Cross-talks among Ets-related transcription factors, such as between E1AF and Ets-1 as shown in our study, may be important for the motile and invasive activities of cancer cells.
Cell invasion is a major component of the complex multistep process of tumor metastasis. Invasion requires both cell motility and degradation of the surrounding extracellular matrix, the latter of which is mediated by a number of proteolytic enzymes.30 In our study, increased cell invasion by E1AF was thought to be a reflection of enhanced motile activity and of increased amounts and activities of uPA and its downstream proteolytic enzymes other than MMP-1, MMP-3 and MMP-9. It has been shown that a high level of uPA expression is associated with invasion and metastasis.31 However, the genetic changes that activate these invasion-associated matrix-degrading proteases in cancers remain to be determined. Many of the Ets-related oncoproteins have been shown to be transcription factors potentially involved in the activation of genes encoding for such enzymes.4, 32 It has also been shown that the transcriptional regulatory regions of the matrix-degrading protease genes often contain Ets-binding sequences,33, 34 and that the Ets-binding sequence is important for activating transcription of MMP genes.35, 36
E1AF is a transcription factor that binds to the Ets-binding sequences.6, 7 Studies using CAT assays have revealed that E1AF can upregulate promoter activities of the genes encoding for MMP-1, MMP-3 and MMP-9.9 It has been proposed that E1AF confers the invasive phenotype in a human breast cancer cell line,10 that E1AF expression is correlated with the transcription of the genes encoding for MMPs and invasive phenotype in oral squamous-cell carcinoma cell lines11 and that the transfection of antisense E1AF restrains invasion of oral cancer cells by downregulating the MMP genes.37 Moreover, the E1AF gene has been shown to form a fusion gene with the EWS gene by chromosome translocation in sarcoma, suggesting its causal involvement in the development of sarcoma.38 These studies, including our study, suggest that E1AF is one of the proto-oncogenes involved in the invasion and metastasis of several types of cancer, including NSCLCs.
In conclusion, E1AF is frequently expressed in resected tumors and cell lines of NSCLCs and is involved in their cell motility and invasion, suggesting that E1AF plays a substantial role in the invasion and metastasis of NSCLCs. These data provide a potential importance of E1AF in NSCLCs, including as a marker for the stratification of patients and a target of therapy.
- 1Non-small cell lung cancer. In: DeVitaVT, HellmanS, Rosenberg, SA. Cancer: principles and practice of oncology, 5th ed. Philadelphia: Lippincott-Raven, 1997. p 858–910., , .
- 2A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature 1983;306: 395–7., , , et al.
- 3Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature 1983;306: 391–5., , , et al.
- 4The Ets family of transcription factors. Eur J Biochem 1993;211: 7–18., , .
- 5Binding sites of HeLa cell nuclear proteins on the upstream region of adenovirus type 5 E1A gene. Nucleic Acids Res 1989;17: 10015–34., , .
- 6Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family. Nucleic Acids Res 1993;21: 547–53., , , et al.
- 7Transcriptional regulation of the adenovirus E1A gene. Curr Top Microbiol Immunol 1995;199: 113–30., , .
- 8Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells. Genes Dev 1992;6: 481–96., , , et al.
- 9Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters. Oncogene 1995;10: 1461–3., , , et al.
- 10A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells. Oncogene 1996;12: 221–7., , , et al.
- 11Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines. Am J Pathol 1996;148: 693–700., , , et al.
- 12Expression of c-ets-1 and urokinase-type plasminogen activator genes in lung carcinomas. Am J Pathol 1995;147: 1298–310., , , et al.
- 13The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades. Oncogene 1996;13: 1323–33., , , et al.
- 14Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering. Oncogene 1998;17: 57–65., , , et al.
- 15Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor. J Biol Chem 1999;274: 16377–86., , , et al.
- 16Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal/adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem 1994;269: 31807–13., , , et al.
- 17Induction of hepatocyte growth factor I fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res 1997;57: 3305–13., , , et al.
- 18Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma cells. Cell Growth Diff 1993;4: 571–9., , , et al.
- 19
- 20Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer. Cancer Res 1997;57: 433–9., , , et al.
- 21WHO. The World Health Organization histological typing of lung tumours, 2nd ed. Am J Clin Pathol 1982; 77: 123–36.
- 22American Joint Committee on Cancer. Lung. In: BeahrsOH, HensonDE, Hutter, RVP, KennedyBJ. Manual for staging of cancer, 4th ed. Chicago: JB Lippincott, 1992. p 115–22.
- 23Basic methods in molecular biology. New York: Elsevier, 1986., , .
- 24RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 1977;16: 4743–51., , , et al.
- 25Eukaryotic expression vectors for the analysis of mutant proteins. Nucleic Acids Res 1989;17: 6418., , , et al.
- 26The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase gene in response to epidermal growth factor. Int J Cancer 1998;77: 128–37., , , et al.
- 27The ETS1 transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter factor-stimulated MDCK epithelial cells. Cell Growth Diff 1997;8: 655–65., , , et al.
- 28Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells. J Biol Chem 1992;267: 20493–96., , , et al.
- 29Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-Met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol 1996;16: 1115–25., , .
- 30Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation. Curr Opin Cancer Biol 1998;10: 667–71., , , et al.
- 31Proteases as prognostic markers in cancer. Clin Cancer Res 1996;2: 613–8..
- 32Stromal expression of c-Ets1 transcription factor correlates with tumor invasion. Cancer Res 1994;54: 5683–8., , , et al.
- 33Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J Biol Chem 1994;269: 2032–40., , , et al.
- 34The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins. EMBO J 1991;10: 1127–34., , , et al.
- 35Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 1993;8: 395–405., .
- 36The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites. EMBO J 1990;9: 2241–6., .
- 37Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities. Am J Pathol 1997;150: 2125–32., , , et al.
- 38Fusion of an ETS-family gene, E1AF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy. Genes Chromosomes Cancer 1996;15: 115–21., , , et al.


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10000HP 25 Points You restored 10000 health points. Medal Stats.
2500HP 25 Points You restored 2500 health points. Medal Stats.
Total Medals Earned: 619 (From 120 different games.)
Favorite Audio
|Powerful and Bright (Teaser) ~
|Video Game Loop
|My Destination
|Video Game Song
|Kick S. Beats ~P~
|Miscellaneous Loop
|'12 Artifical Intelli Rmx
|Cinematic Song
Favorite Art
Favorite Movies
Xionic Madness 4 Part-3 Rated 4.4551 Stars Xionic Madness' conclusion Action Xionic Madness 4 Part-2 Rated 4.4667 Stars Omega and Xero's desperate struggle for survival reaches new heights. Action Xionic Madness 4 Part-1 Rated 4.4393 Stars Xionic Madness's saga last installment. Part one. Action Xionic Madness 3 Rated 4.4336 Stars A la verga aquí está >:D! Action
Favorite Games
Pretentious Game 3 Rated 3.9351 Stars Explore more of the story from each of the characters point of view. Action - Platformer - Puzzle Submachine 8: the Plan Rated 4.2990 Stars The submachine is all around you. Adventure - Point 'n Click Windows Doors Rated 4.3276 Stars Life without Windows. Simulation - Other Madness: Project Nexus Rated 4.4619 Stars Blaze through the Madness Universe in this sidescrolling Shoot 'Em Up! Action - Shooter - Run 'n Gun


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AdvertisementWhy ads?
Narrow year range (drag arrows to filter):
Everything about the 2015 Chevrolet Tahoe is new this year. It now rides on an all-new frame derived from the new-for-2014 Chevrolet Silverado. The engines have been upgraded with advanced technology to improve horsepower and fuel economy, and the new interior could be out of luxury sedan.
There are few changes to the Chevy Tahoe for 2014. LS models receive a standard Convenience Package that includes power-adjustable pedals, remote start and rear park assist with rear-vision camera and inside mirror with camera display. Concord Metallic is a new color choice.
The Chevy Tahoe has no major changes for 2013. It just gets a higher-capacity battery and a couple of new exterior colors, and the grade braking function, which uses engine compression to help slow the vehicle when going down hills, now works in the normal transmission mode instead of only in the Tow/Haul setting.
The 2012 Chevrolet Tahoe SUV gains a new navigation radio as well as adds trailer sway control and hill start assist to its standard StabiliTrak electronic stability control. The LTZ trim gains a heated steering wheel, side blind zone alert and heated and cooling front seats, while the LT trim gains heated front seats.
Changes for 2011 include the addition of integrated trailer brake control to the Trailering package, some new colors and the availability of 20-inch chrome wheels on the LTZ trim. The LS trim gains as standard equipment Bluetooth, rear seat audio controls, premium cloth seats, luggage rack center rails and body color door handles and mirrors.
All 5.3-liter engines now feature variable valve timing and are E85 compatible. A new USB port is added to all models, while the Z71 off-road suspension is now available on the 1LT trim. A single-speed transfer case is made standard on all four-wheel-drive models, with a two-speed unit offered as optional equipment.
Big space and big capabilities have made the 2013 Chevrolet Tahoe America's favorite full-size SUV. Properly equipped, the brawny body-on-frame vehicle, based on a truck-type construction, can seat up to nine passengers, tow 8,500 pounds and manage well off-road. That keeps the Tahoe at the head of its class, which includes the Ford Expedition, Toyota Sequoia and Nissan Armada. Delivering EPA highway fuel-economy figures in the low 20-mpg range, and including in its lineup (along with its sibling, the GMC Yukon) the only hybrid in the segment, for its size the Chevy Tahoe is about as efficient as can reasonably be expected. But, unless you will actually use the Tahoe's towing capacity and off-road capabilities, a large unit-construction crossover, such as the Ford Explorer, Dodge Durango or Chevy's own Traverse, is a much more efficient, and more sensible, alternative.
By Captain50 on Wednesday, July 23, 2014
I own this car - My approximate mileage is 650overall rating 8 of 10rating details
Pros: "Nice ride and handles great"
Cons: "Can almost see the clock and temperature-too small"
Likely to recommend this car? (1-10): 6
"I must admit that I have mixed feelings on my purchase. With only 650 miles I have had service as at highway speeds I had vibrations and the passenger seat electronics are bad and needed to order parts, a little concerned with only 650 miles and this wasn't an inexpensive purchase. My past Tahoe ran like a champ with 165,000 miles, my only reason for getting rid of it was it had an oil leak, rear main."
19 people out of 22 found this review helpful
Was this review helpful to you? yes | no | report abuse
By Sniper on Tuesday, July 08, 2014
I own this car - My approximate mileage is 3,000overall rating 9 of 10rating details
Pros: "Very comfortable and laid out nicely"
Cons: "Extremely Pricey"
Likely to recommend this car? (1-10): 10
"Only problem I have is with the electronic throttle. Takes some getting used too."
9 people out of 11 found this review helpful
Was this review helpful to you? yes | no | report abuse
By ryan92683 on Tuesday, July 29, 2014
I own this car - My approximate mileage is 4,500overall rating 4 of 10rating details
Pros: "great look. Comfortable seats, safety features"
Cons: "Suspension on LTZ is unbearable."
Likely to recommend this car? (1-10): 1
"My 4x4 LTZ Tahoe drives like it is on a railroad track. With extensive experience driving the older LTZ Tahoes and Suburbans, I can tell you the ride quality on the 15 LTZ is completely lacking. I purchased this car because of the premium, magnetic suspension, and I have been thoroughly disappointed, as the ride is unbearably harsh. I am almost contemplating trading this car in unless GM fixes this, as I cant imagine driving this thing for another 5+ years. I must say GM did do a fine job with the refresh overall though. I just wish the ride was much more comfortable."
38 people out of 55 found this review helpful
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text:
Clare Bridge of Murrysville Senior Apartments5300 Old William Penn Hwy., Export, PA 15632
- Call for rates
- 1 Bed
Welcome to Clare Bridge of Murrysville, located in Export, Pennsylvania. As a senior community specializing in Alzheimers and dementia care, our goal in everything we do is to help residents feel safe throughout their day and live meaningful lives. Our Clare Bridge brand and Daily Moments of Success programming provide each resident with an individualized care plan that anticipates and adjusts to their changing needs. Clare Bridge of Murrysville is a part of Brookdale Senior Living. Since 1978, Brookdale has demonstrated exceptional pride and commitment to the quality and services provided to our senior residents. Featured Amenities Clare Bridge of Murrysvilles interior spaces are intimate and inviting, thoughtfully furnished to look like real homes. Our campus provides a secure environment, ideal for those with memory loss. Residents can freely relax in the cozy family room, enjoy a good book in the library, visit our on-site beauty/barber shop or tend the planted flower boxes in the outdoor courtyard. Our beautiful private and companion suites are bright and cheery, offering a choice of furnished or unfurnished units. We encourage residents to personalize their spaces with furnishings, photos and cherished belongings. A much-loved pet is always a welcome addition to our happy community. Available Services Our Clare Bridge Daily Path program focuses on the individual needs of each resident and family we serve. Services are built around maintaining structu
Clare Bridge of Murrysville is a senior apartment community located in Export, PA. View this 55+ apartment on a map.
Professionally Managed By: Clare Bridge of Murrysville
Community Features
- 24-Hour Staffing
- Beauty/Barber Shop
- Full-Time Activity Director
- Help with Activities of Daily Living
- Kitchenette
- Memory Care
- Outside Patio/Gardens
- Respite Care
- Senior Homes
- Air Conditioning/Climate Control
- Emergency Call System
- Furnished Units
- Housekeeping
- Medication Management
- Other Transportation Provided
- Private Units
- Semi-Private Units
- Transportation to Medical Appointments
*Note: In Select Units


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The Metropolitan Transportation Authority's (MTA) Metro-North Railroad named three veterans of the railroad industry to top leadership positions.
The railroad's new President, Joseph Giulietti, announced the appointment of Glen Hayden as VP, engineering; Michael J. Yaeger as chief mechanical officer; and Kevin J. O'Connor as chief transportation officer.
"I am confident that this highly experienced team will provide the leadership that Metro-North needs to refocus all its attention on safety, reliability and customer service and in the process rebuild its reputation for excellence," Giulietti said.
Hayden will lead Metro-North's Maintenance of Way Department, which is responsible for the integrity of the track and associated structures, and will report directly to the president.
During the last 16 years, Hayden worked for Parsons Brinkerhoff, where he was responsible for planning and/or project management for a number of large, complex and critical transportation projects throughout the northeast. He spent much of his early career at Metro-North and its predecessor railroads, rising to the position of chief engineer.
Yaeger and O'Connor will report to Metro-North sr. VP, operations, John Kesich.
Yaeger will be responsible for maintenance of the railroad's fleet of railcars and work trains. He has spent 27 years at Metro-North in the maintenance of equipment department – both in the areas of project planning and in maintenance operations.
Meanwhile, O'Connor will be responsible for the day-to-day operation of trains. He succeeds asst. VP John McNulty, who is retiring this summer after 40 years at Metro-North.
During his 36-year career in railroading, O'Connor rose through the ranks, starting at Amtrak where he began his career first as a service attendant, block operator and train dispatcher, then in progressively responsible positions in operations management for Amtrak and New Jersey Transit, where he most recently served as VP/GM, rail operations.
The Transportation YOU DC Youth Summit spanned five days and included a visit to USDOT to meet with some of the young women from various modes who have chosen transportation as a career, and a meeting with Victor Mendez, Deputy Secretary of the U.S. Department of Transportation.
Under Steve Townsend's leadership, Keolis has successfully expanded into the commuter rail and transit markets in the U.S., winning contracts to operate the Virginia Railway Express and the Massachusetts Bay Transportation Authority commuter rail system.
Prior to joining LYNX, John Lewis served as the CEO of the Greater Richmond Transit Company.
Together, the companies will offer multiple transportation options accessed through one platform, with booking and payment integrated to allow for a seamless experience.
The drivers' union president said the strike will begin at 3 a.m. Wednesday. Both sides are set to meet with a mediator Tuesday for one last opportunity to reach a deal.
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I cut the pattern out using a single layer, and was successful in matching the main features of the plaid.
I don't know what I did with that left dart but let's just call it good until I get all of the top together.
I am using B5924 View B and plan to use this top with jeans for riding. I cut a 10 through the shoulders and a 12-14 elsewhere. This pattern has ABCD cup sizes and I chose to use the C cup size. We will see if I choose right. I have been weight lifting and walking on the treadmill 3 x/week. Only 2 lbs down so far.
As I was sewing the pieces together, I got a bit frantic about whether to match it vertically or horizontally as the pattern has tops and bottoms to each front and back. I matched horizontally as that was most obvious. On the back I matched horizontally first and discovered a way to be more accurate.
I basted each dark band first, and then basted on the stitching line. After checking, I stitched right over the basting. If this were not for riding, I would stitch next to the basting and then remove it.
Here is what the result is on the center back seam.
I am happy with this and know that any un-matched spots won't be visible as I am riding. No one looks at me anyway as my horse Nick is so strikingly handsome!
Besides exercising any OCD tendencies with plaid, I have also set aside some projects to sew through the summer heat. Organizing pattern and fabric together keeps me focused on my wardrobe choices and lessens distraction from other sewer's projects. I love to see what everyone else is creating, and I am easily led :-) so this helps me keep to my program.
I need loose, stylish clothes for kicking around town and these patterns will help. Next up will be another Ina skirt in this marvelous cotton knit I found at Hancock's for 50% off. I love these greens and they look awful next to my face but in a skirt...they will be gorgeous :-)
I hope everyone is staying busy, happy and engaged in creative pursuits.


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Update – Aberdeenshire Council – 29th May 2015
EV and 2nd wave cases
We represent 52 claimants with on-going equal pay cases against Aberdeenshire Council. Due to ongoing delays we requested a Preliminary Hearing which took place on 21st May 2015 in the Aberdeen Employment Tribunal. A further hearing has been arranged for 30th June 2015.
Following robust submissions the Judge has ordered the Council to clearly state their defence to these equal pay cases within 21 days of the last PH. No substantial hearings have taken place against Aberdeenshire. Full hearing dates will need to be listed later this year. However before legal arguments can take place at any 2nd wave hearing the Council must state clearly whether they have any defence to these cases, and if so the nature of any defence, and whether they had knowledge of pre-existing pay inequality. We expect further progress to be made at the next PH at the end of June.
There are also a small number of equal value claimants who have not received any settlement. Some of these cases date back to 2005 may be due compensation back to 2000. Further delay will only result in additional costs to the Council as interest is added at 8%. We have tried to engage this Council in settlement discussions but to date have had no constructive response.
We understand that the political leadership of Aberdeenshire Council has recently changed. This may influence the Council's strategy towards this litigation and we would urge all claimants to lobby their local Councillors, MP and MSP to question why the Council has yet to resolve these equal pay cases. Some cases have been lodged for nearly 10 years.
We will keep you advised of developments and will post updates when we can. We thank you for your continued patience and cooperation.
Carol Fox
29th May 2015


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In 2012 while playing for South Carolina, running back Marcus Lattimore suffered a nearly catastrophic knee injury. His mother tells the story of that day.
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Pronunciation: Magha Puja
Added on: 2010-01-21 Listened: 736 timesin: Thai holidays
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text: Kathleen E. McLaughlin on May 16, 2011 @ 6:07 AMMay 16, 2011 @ 6:07 AM PublishedAi Weiwei's wife allowed visitChinese artist Ai Weiwei sits in the courtyard of his home in Beijing on November 7, 2010.Prominent artist and government critic Ai Weiwei has been allowed to see his wife, his first outside contact since police grabbed him at the Beijing airport more than one month ago.The government has said it is investigating Ai for "economic crimes," but has filed no formal charges against him. His wife was allowed to see him for about 20 minutes on Sunday at an undisclosed location, the Associated Press reported, in a meeting during which the couple did not talk about why Ai had been detained or the outlook of the situation."We could not talk about the economic charges or other stuff, mainly about the family and health," Lu Qing, Ai's wife, told the AP. "We were careful, we knew that the deal could be broken at any moment, so we were careful."Ai has been a vocal critic of China's heavy-handed tactics on its own citizens. Among other work, he has documented the numbers and names of students who died in the 2008 Sichuan earthquake, many believed to have perished in shoddily built schools thanks to rampant corruption.Attorneys have said Ai's current extra-judicial detention is not in keeping with China's own laws, but amid the country's ongoing crackdown on dissent, he is not alone. Dozens of lawyers, writers and others have been detained without charges, some released and some still missing. Among them is Wen Tao, a former journalist for official state media who was working with Ai when he disappeared the same day.


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Cable Highlights The MHP panel talks about the issues facing our water infrastructure, from water pollution to water droughts and shortages.
Cable Highlights Alex Witt talks to NBC News Olympic Security Analyst Andrew Weiss about the current state of affairs at the Sochi Olympics and Russia.


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The new Yardbarker app is here! Install on your iPhone, iPad or Android device. You can also find us in Google Newsstand.
Orioles hit 2 HRs to back Chen in 4-2 victory over Rangers
BALTIMORE (AP) J.J. Hardy hit a tiebreaking two-run homer in the seventh inning to back an effective pitching performance by Wei-Yin Chen and carry the Baltimore Orioles past the Texas Rangers 4-2 on Wednesday night. Jimmy Paredes homered and had two RBIs for the Orioles, who yielded eight home runs in losing the first two games of the series. The Rangers went deep twice more -...
Via AP on Fox
1 day ago | Discuss
Orioles option LHP McFarland to make room for Chen
BALTIMORE (AP) The Baltimore Orioles have recalled left-hander Wei-Yin Chen from the minor leagues and optioned reliever T.J. McFarland to Triple-A Norfolk. Chen started Friday night against Cleveland. He was optioned to Single-A Frederick on June 16 and pitched in one game there. McFarland is 0-1 with a 3.18 ERA in three stints with the Orioles this season. Baltimore is poised...
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Baltimore Orioles return home to face Cleveland Indians
The Baltimore Orioles are coming off of an eight-game road trip in which they finished 5-3, and picked up series wins in both Toronto and Boston. They now sit at 38-34 on the year, a season-high four games above .500. Now, the Orioles return home for a seven-game homestand, which will start with three games this weekend against the Cleveland Indians. The Orioles took two out of three...
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7 days ago | Discuss
Baltimore Orioles Undervalue Wei-Yin Chen's Solid Pitching
BALTIMORE, MD – JUNE 15: Starting pitcher Wei-Yin Chen #16 of the Baltimore Orioles throws to a Philadelphia Phillies batter in the second inning at Oriole Park at Camden Yards on June 15, 2015 in Baltimore, Maryland. (Photo by Rob Carr/Getty Images) In a surprising move, the Baltimore Orioles have optioned their third-year starting pitcher Wei-Yin Chen to Class A, citing a general...
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Baltimore Orioles: Analyzing latest roster changes
It has been anticipated for a couple of days now that the Baltimore Orioles would bring up outfielder Chris Parmelee for an audition in the majors. However, it is the player optioned down that was not anticipated. Starting pitcher Wei-Yin Chen was sent down to make room for the new outfielder and will not return until June 26th. Chen is coming off a masterful shutout performance...
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16 days ago | Discuss
Orioles option Chen to minors and bring up Parmelee
BALTIMORE (AP) Left-hander Wei-Yin Chen has been optioned to Class A Frederick by the Baltimore Orioles, who have selected the contract of infielder Chris Parmelee from Triple-A Norfolk. Chen (3-4) complained of fatigue following his June 10 start and pitched eight scoreless innings Monday against Philadelphia. Orioles manager Buck Showalter said Tuesday that Chen was sent down...
Via AP on Fox
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Chen sharp for 8 innings as Orioles blank Phillies 4-0
BALTIMORE (AP) Wei-Yin Chen pitched eight innings of four-hit ball, Matt Wieters hit a three-run homer and the Baltimore Orioles beat the skidding Philadelphia Phillies 4-0 Monday night. Chen (3-4) struck out nine and walked one to help the Orioles win for the ninth time in 11 games. The eight innings tied his career high and was the longest stint by an Orioles starter this month...
Via AP on Fox
17 days ago | Discuss
Daily Pitcher Duels: June 4
â It's a getaway Thursday as just 20 MLB teams are in action wrapping up series' before moving on to the weekend. And while there's no strong standout matchup, there are still enough individual pitchers going to make it worth your while. Check 'em out: Wei-Yin Chen (BAL) vs. Dallas Keuchel (HOU) 2:10 p.m. ET It's a lefty battle at Minute Maid Park as Chen and...
Via The Sports Post
29 days ago | Discuss
Baltimore Orioles: July recap and August preview
Orioles' pitcher Wei-Yin Chen went 4-0 with a 2.92 ERA in July. In a month that featured the All-Star Game and trade deadline, there are many things to focus on that took place. Most importantly however is a teams record, and for the Baltimore Orioles, it's hard to find anybody who had a better one in July. The Orioles finished the month of July with a 17-8 record, putting...
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August 03, 2014 | Discuss
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Course schedule for spring-summer semester is now online!
Saint Paul University's course schedule for the spring-summer semester is now available on our website.
Courses that are offered twice per week start, generally, on May 1 and run until June 11. To register for spring/summer courses, you must complete the registration form that is available on our website. The form to complete is the following:
- For Saint Paul students registered in an undergraduate program
- For Saint Paul students registered in a graduate program
- For special students who wish to register for one or two courses
Please complete the registration form and submit it to the appropriate academic advisor.
For undergraduate programs and courses:
For graduate programs and courses:
Francine Quesnel
If you wish to meet with an academic advisor to complete your course selection for the spring/summer semester, please contact the appropriate advisor by e-mail to schedule a meeting.
Other Links
- Saint Paul University's Faculty of Theology honored to accept accreditation from the Association of Theological Schools
- Saint Paul University is pleased to welcome teachers from the Conseil des écoles catholiques du Centre-Est!
- Congratulations to our graduates!
- Saint Paul University Announces $2.5-Million Gift for New School of Social Innovation
- Call for papers: Positive Psychology and Spirituality


text:
Robin hood tax | robin hood tax, With the reintroduction of the robin hood tax, bill 1464, rht supporting organizations told us what they would do with $300b. more info » hr 1464 introduced. Mom foodie - blommi — mom food blog, healthy lifestyle, Mom food blog, healthy lifestyle, recipes, home and garden, diy, cooking tips, rhode island. Robin hood (1973) - imdb, Directed by wolfgang reitherman. with roger miller, peter ustinov, terry-thomas, brian bedford. an imaginative disney version of the robin hood legend. fun and.
Red robin® gourmet burgers | redrobin., Welcome red robin ® gourmet burgers. learn insanely delicious burgers build . find red robin ® !. http://www.redrobin.com/ Robin' chicks, Writer. ninja mother. bringing funny. freelance writer, author stay--home-mom daughters born years.. http://www.robinschicks.com/ Masternewmedia - robin good' feature articles, Robin good' master media daily online magazine targeted individuals, small businesses, communicators media professionals passionate . http://www.masternewmedia.org/


text:
pinstripe columnist ankle pant
The head-turning tailoring of our Columnist pant, freshly revised. Slightly cropped, slimmed down to caress every curve, and finished with a classic pinstripe, these bring modern sophistication to almost any situation.
- Low rise, slim fit, skinny leg with 27" inseam
- Hidden hook and button closure, zip fly
- Slant hand pockets, welt back pockets
- Welt back pockets
- Cotton/Polyester/Elastane
- Machine wash
- Imported


text:
I have the following files with me.
aps_dev_cert_key.p12 aps_developer_identity.cer and apxxx_dev.mobileprovision
Same set exists for distribution too. Now, I went to Keychain access, dragged key file onto "Keys" and cer file onto "Certificates". I followed the instruction in this post How to install the iPhone application on my iPod touch
But Build & Run is not working for me, as I get "The Identity xxxxyyyyzzzzzxxxxx doesn't match any valid certificate/private key pair in default keychain"


text:
Boosted by strong activity in Santa Clara and Sunnyvale, Silicon Valley posted the 13th straight quarter of positive office leasing activity in Q2, the longest stretch since the dot-com boom, brokerage JLL said.
Early stage investment firm Costanoa Venture Capital has added Neill Occhiogrosso as its second partner.
The IPO roared back in 2013, with more U.S. companies going public and more money raised than in any year since the dot-com boom went bust in 2000.
Silicon Valley tech companies like Apple, LinkedIn and Juniper Networks Inc. grew their real estate footprints more than other industries did over the ...
Violin Memory's big IPO announcement wasn't the only news coming out of the company.
IPO action is showing signs of heating up with Monday's filings by flash storage startup Violin Memory and cloud telephony company RingCentral.
Facebook finally got back to its IPO offering price on Wednesday, if only briefly, about 14 months after going public at $38 a share.
Venture-backed company IPOs in the U.S. hit a five-quarter high in the period ending in June but M&A's and funding were down sharply compared to last ...
There were 21 venture-backed initial public offerings in the second quarter, boosted by the largest amount of quarterly activity within biotech since ...
Shares of Gigamon surged by nearly 50 percent in their first day on the New York Stock Exchange on Wednesday.
Gigamon, which makes data traffic management software, sold $128.25 million worth of stock in its initial public offering late on Tuesday.
Data traffic management software maker Gigamon is expected to sell up to $135 million in shares late on Tuesday as it prepares to debut on the New Yor ...
Gigamon, the data traffic management software developer, set a target range for an upcoming IPO that could raise as much as $135 million.
Figuring out who was getting ready to go public used to be easier. Just watch for the regulatory filings.
Palo Alto Networks Inc. on Tuesday boosted the target for its expected initial public offering this week by about 8 percent.


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Richard Gasquet v Feliciano Lopez (Eastbourne Final)
No copyright infringement intended. All rights to LTA/ATP....
- published: 16 Nov 2014
- views: 147
British number three James Ward was beaten 3-6 6-2 6-4 by Feliciano Lopez at the BNP Paribas Open in California. Ward was given a lucky loser spot in the tournament after...BBC News 2014-03-10
Marcos Baghdatis held his nerve to prevail over Feliciano Lopez and take Pune Marathas to a second straight victory in the Champions Tennis League, at the KSLTA Stadium...The Hindu 2014-10-28
Bangalore Raptors fell to its third consecutive defeat in the Champions Tennis League, its hopes of progress in the competition ending tamely at the KSLTA Stadium here on...The Hindu 2014-10-28
A shoulder injury will restrict Germany's veteran Tommy Haas to the doubles for this weekend's Davis Cup World Group first round match against Spain, which starts on...The Times of India 2014-01-30
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MELBOURNE, Australia – Three-time finalist Andy Murray advanced to the fourth round at the Australian Open for the sixth straight year with a 7-6 (2), 6-4, 6-2 win over No. 26-seeded Feliciano Lopez of Spain on Saturday. Murray, playing only his second tournament since...Fox News 2014-01-18
(Source: LTA - The Lawn Tennis Association ) We are delighted to announce grass court specialist Feliciano Lopez will be completing his Wimbledon preparations at the Aegon Open Nottingham in 2015. The Spaniard is currently enjoying a career high ranking of world no.12 and has proved to be a master on the surface in recent years. Three-time Wimbledon quarter-finalist, Lopez, won...noodls 2015-03-24
Published October 11, 2014Associated Press Facebook0 Twitter0 Email Print Gilles Simon of France returns a shot against Feliciano Lopez of Spain during their semifinal match at the Shanghai Masters tennis tournament in Shanghai, China, Saturday, Oct. 11, 2014. (AP Photo/Vincent Thian) (The Associated Press) Gilles Simon of France acknowledges the crowd after defeating Feliciano...Fox News 2014-10-11
Feliciano Lopez. Photo: AP Spain's Feliciano Lopez got his ATP title defence in Houston off to a smooth start with a 6-3 6-3 win over Australian Sam Groth. Lopez, ranked a career-high 12th in the world and the top seed in the clay court tournament, booked a quarter-final clash with eighth-seeded American Sam Querrey. "I'm very pleased to be here again," the 33-year-old Spaniard...Canberra Times 2015-04-09
MEMPHIS, Tenn. – Kei Nishikori of Japan won his third career title and second since October, beating Feliciano Lopez of Spain 6-2, 6-3 in the U.S. National Indoor Championships on Sunday. Nishikori needed only 67 minutes to improve to 3-2 in finals. He won his...Fox News 2013-02-24
(Source: Australian Open Tennis Championships ) Lopez wins emotional encounter Spain's No.12 seed Feliciano Lopez sees off Poland's Jerzy Janowicz, 7-6(6) 6-4 7-6(3), to earn a place in the last 16 to face Milos Raonic. Saturday, 24 January, 2015 After saving match points in the first round and taking advantage of a retirement in the second, the luck continues for Spanish 12th...noodls 2015-01-24
Tomas Berdych battled his way into the Aegon Championships quarter-finals with a straight-sets victory over Adrian Mannarino. The 28-year-old Czech second seed slugged past the French world No 83 in a lengthy two sets, 7-6 (7/2) 6-4 to set up a last-eight clash with world No 28 Feliciano Lopez. World No six...Sky Sports 2014-06-12
Feliciano López Diaz-Guerra (Spanish pronunciation: [feliˈθjano ˈlopeð ˈðiaðˈɣera]; born 20 September 1981) is a Spanish professional male tennis player. He was born in Toledo and now lives in the Spanish capital, Madrid. Lopez achieved his current career-high singles ranking of World No. 15 in February 2012.
In 2005, he was the first male Spanish tennis player to reach the quarter-finals of Wimbledon since 1972, when Manuel Orantes reached the semi-finals. This was Lopez's best Grand Slam result thus far and he repeated it at Wimbledon in 2008, losing to Marat Safin in four sets, and again in 2011, losing to Andy Murray in straight sets. Lopez defeatd Tim Henman at the 2007 Wimbledon second round in what would be Henman's last Wimbledon match. He is sponsored by Wilson and Joma. In 2009, he played the then-longest match in Australian Open history, losing to Gilles Müller, before the Novak Djokovic–Rafael Nadal final and Rafael Nadal-Fernando Verdasco semifinal eclipsed it in time. Throughout his career, he has played in the most 5 set matches that have gone beyond 6–6, his longest fifth set being 16–14 at the 2009 Australian Open against Gilles Müller.