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My Project
What I am studying
The hippocampus is a brain structure that is involved in memory formation, where inputs (contextual information) are processed here and converted to outputs (firing of pyramidal cells). The firing of pyramidal cells are regulated by more than 20 types of inhibitory interneurons, and we still don't know exactly how this works.
I am studying one type of interneuron, called the neurogliaform cells (NGFCs), to see how they function within the hippocampal circuit. NGFCs form synapses onto the distal tufts of pyramidal cell apical dendrites alongside excitatory inputs from the entorhinal cortex. NGFCs also express neuronal nitric oxide synthase (nNOS), are often synaptically coupled, and fire during theta oscillations in vivo.
Show figure of hippocampal interneuron subtypes
Peter Somogyi and Thomas Klausberger, The Journal of Physiology, 2005
What I have found, a summary
In this project, I describe a novel feature of synaptic communication between these interneuron types, hereafter referred to as the firing induced suppression of inhibition (FSI). Specifically, I found that when a theta-associated activity patterns were evoked in NGFCs from rodent hippocampal slices, the cells showed a transient reduction in unitary IPSP amplitude. My data suggest that FSI requires the backpropagation of action potentials, calcium influx through L-type calcium channels, nNOS activity within the dendrites of interneurons, and activation of NO-sensitive guanylyl cyclase (NOsGC) receptors, which are present on presynaptic terminals. My results also demonstrate the physiological impact of this phenomenon by showing that when FSI takes place the strength of incoming excitatory postsynaptic potentials onto NGFC is transiently sharpened. Specifically, FSI indirectly increased the amplitude of EPSPs. Thus FSI may enhance spatial and temporal summation of excitatory inputs to NGFCs, thus regulating their inhibition of pyramidal cells.
Here are the details
1. In vivo firing induces suppresion of inhibition (FSI)
I have recorded the unitary inhibitory postsynaptic potentials (uIPSPs) or currents (uIPSCs) from synaptically-coupled putative NGFCs or other interneurons with the soma in the SLM of the rat hippocampus in vitro. Neurons were recorded with a high chloride internal solution were used to increased the signal of these events and as a result these events were depolarising potentials or inward currents. A firing sequence (60 s duration, average frequency and CV values: 8.3 Hz, 0.75; stimulation protocol) was recorded in a rat NGFC in vivo during theta oscillations (Fuentealba et al., 2010) and which was injected in current clamp configuration in a postsynaptic interneuron of the SLM recorded in vitro. I have found that shortly after (125 or 250 ms) the firing of the postsynaptic cell from the in vivo sequence, there was a transient decrease in the amplitude of the uIPSPs recorded in current clamp or voltage clamp configuration. The kinetics of baseline and decreased uIPSCs evoked before and immediately after the stimulation protocol was similar, suggesting that presynaptic mechanisms were more likely than postsynaptic mechanisms to be responsible for the decrease of the synaptic responses.
In summary, I have found that in vivo NGFC firing during hippocampal theta rhythm induces a DSI-like event (FSI) recorded from pairs of interneurons with the soma in the SLM. The following experiments have been designed to study the cell types and mechanisms involved in this phenomenon.
2. What happens during in vivo firing?
FSI is temporally-correlated with the postsynaptic firing, but is postsynaptic cell firing required for FSI? I have studied this question by using a subthreshold protocol and found that a subthreshold protocol was unable to induce FSI in all cell pairs tested. This result suggests that FSI was initiated by the postsynaptic neuron firing, indicating that active processes were likely to be involved. According to this result, Action potential backpropagation (bAP) could be one of the active processes that occur, namely bAP travels along the postsynaptic dendrites in order to trigger FSI. To test this hypothesis, I have visualised bAPs in interneurons of the SLM by using single cell voltage imaging and they show robust action potential backpropagation
A possible function for bAP is to activate downstream enzymes that are responsible for the synthesis of retrograde signalling molecules. According to this idea, I have tested the hypothesis that the postsynaptic bAPs may elicit an increase in the dendritic calcium concentration. Using calcium imaging I have found that cell pairs showing FSI have higher dendritic calcium level.
Using pharmcology I have found this calcium influx is indeed through calcium channels (L-type) and not from stores.
3. Which messenger(s) is responsible for FSI?
Using pharmacology I have found that nitric oxide is responsible for FSI. FSI is blocked by the application of the nNOs inhibitor L-NAME, NOs-GC antogonist ODQ, and potentiated by the nitric oxide precursor L-arginine.
4. What are the physiological implications of FSI?
To test the physiological role of FSI on single cell integration, I have injected a train of EPSPs as synaptic conductance by using dynamic clamp (dEPSPs) in postsynaptic NGFCs. Since NGFCs have short dendrites and are biophysically compact, the somatic injection of unitary dEPSPs should represent a realistic representation of EPSPs evoked by stimulation of one or a few fibres present in the SLM, such as the perforant path from the entorhinal cortex. I observed that when FSI occurred, the amplitude of the dEPSPs was significantly increased compared to dEPSPs elicited in the presence of control synaptic inhibition before or after FSI (note, normal chloride internal solution was used). Thus, FSI transiently increased the size of the dEPSPs thereby promoting the temporal/spatial integration of the uEPSPs elicited by stimulation of perforant path/other excitatory fibres present in the SLM.


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subset: commoncrawl


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Egypt's Foreign Minister Mohamed Kamel Amr called on the Non-Aligned Movement (NAM) to offer more support to the Palestinian people in facing Israel's attempts to annex more Palestinian lands and change the identity of the Holy city of Jerusalem.
This came during a ministerial meeting of NAM's Palestine Committee held on Tuesday 5/2/2013, on the sidelines of the Islamic foreign ministers meetings ahead of the 12th Islamic summit slated for Wednesday 6/2/2013.
NAM should offer necessary support to the Palestinian cause until a decision on the establishment of the Palestinian state is taken, he said, adding that this requires further efforts in order to protect Jerusalem as a capital of this state and the Palestinian territories in general.
He underlined the need to reach Palestinian reconciliation and end division. He also stressed Egypt's intention to exert more efforts in this respect.
The committee meeting was chaired by Iran in its capacity as the current NAM chair.


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Partial Biotinidase Deficiency (Partial BIOT)
Partial biotinidase deficiency (Partial BIOT) is an inherited condition in which the body is unable to reuse and recycle the vitamin biotin. Partial BIOT is a milder form of BIOT but can cause serious symptoms including hypotonia, skin rashes, hair loss, developmental delay, and neurologic symptoms. These symptoms may worsen during illness, infection, or times of stress. Children found to have partial BIOT through newborn screening and who begin treatment soon after birth usually remain healthy with normal development.
To learn more about Partial Biotinidase Deficiency, visit Baby's First Test: biotinidase deficiency and U.S. National Library of Medicine: Partial biotinidase deficiency. Visit Board Certified Metabolic Providers (PDF: 2 pages/204KB) for a listing of medical specialists and clinic contact information.


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Start Planning With Our Holiday Menu Ideas
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In this issue of Joy of Kosher with Jamie Geller we share three Holiday menu ideas, Italian, Moroccan and Traditional. Here online we have all kinds of menus for you to start your planning and more to come.
A Rosh Hashnaha Menu from Susie Fishbein
4 Simanim Inspired Quick & Kosher Rosh Hashanah Menus
Rosh Hashanah Recipes and Pictures by Danny Lerner
Conversations and a Menu from Levana
Yom Kippur Pre and Post Fast Meal Ideas
Break the Fast Memories and Menus
Break Fast Ideas from Ronnie Fein
Sticky Buns for Break the Fast
Fasting Tips with a Pre Fast Menu
A Sukkot Menu from Susie Fishbein
Simchat Torah Menu Quick & Kosher Style
A Simchat Torah Carnival Inspired Menu from Susie Fishbein
Posted in
Holidays , Holidays & Guides , Home Rotator , Online Features , Rosh Hashanah , Simchat Torah , Sukkot , Yom Kippur
About Tamar Genger MA, RD
3 Responses to Start Planning With Our Holiday Menu Ideas
found your magazine at the kosher butcher and loved it. Can't wait for more help for the High Holidays and other family food events


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Only hotels in Gardendale are listed below. Find discounted hotel accommodations in or close to Gardendale, AL for your personal leisure or group travel. We list the best Gardendale Alabama hotel/motel rooms. Review the Gardendale hotel list below to find the perfect lodging. We also have a map of the Gardendale hotels. Group booking? Search Gardendale Group Hotel DealsThe Gardendale center point is approximately 3 miles from Downtown Fultondale and 5 miles from Jefferson State Community College.
Gardendale Hotels/Motels & Accommodations
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Definition: A booker is anyone who has a signed corporate rate agreement or any corporate contracted business with JA Resorts & Hotels.
Benefit: The booker can redeem either 1 points per AED 100 materialized and paid revenue (excluding Municipality fee and Service Charge) for High Street Vouchers or 5 points per AED 100 of materialized and paid revenue for JA Resorts & Hotels vouchers. Each Point is the equivalent to AED 1
Example: AED 50,000 (excluding Municipality fee & Service Charge) The following could be redeemed:
AED 500 worth of High Street Vouchers or AED 2500 worth of JA Resorts & Hotels vouchers Terms & Conditions


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San Dieguito to begin first Prop. AA projects this year
First projects funded by Proposition AA bond sales are set to begin this year
In the next few years, residents in the La Costa Valley neighborhood will get new playing fields, parents at Diegueno Middle School will have a much easier time dropping off their children at the campus and students at Sunset High School will finally have permanent buildings.
Those are among the projects the San Dieguito Union School District expects to fund with money from Proposition AA, a $449 million bond initiative approved by voters in November.
The first of three series of bonds — about $160 million worth — are expected to go on sale to investors in about a month, said Eric Dill, associate superintendent of business services for the district.
Work is expected to begin this year on several projects, with the final projects beginning in 2020.
Dill said planning for future needs in the San Dieguito district began with the arrival of Superintendent Ken Noah in 2008.
The oldest school in the district was about to turn 75 that year, and Dill said district officials realized there was disparity among the campuses. The district launched a two-year evaluation of campus conditions.
"Each school had a wish list," Dill said. "Out of that came the district's master plan."
Among the projects on the list for this year will be some work on property the district bought in 1999 for a middle school in La Costa Valley. While the district is waiting for growth in the area to warrant the school's construction, it will begin a $16.7 million project this year to make improvements on the property, including new playing fields and a gymnasium.
Those facilities will be used by the district's adult education program and La Costa Canyon High School students, but La Costa Valley residents also will be able to use the fields when students are not on them, Dill said.
A $78.8 million project at the 40-year-old Torrey Pines High campus will also begin this year with new stadium lighting, access to a fire road and a water main replacement. In 2015, the school will get a new performing arts center and improvements to technology and infrastructure.
The 77-year-old San Dieguito Academy campus, which last had a modernization project in 2004, will begin $71 million in projects this year with a new track and field. The school is set to get a new two-story math and science building in 2015, a two-story English, social science and arts building in 2016 and a new gym and upgraded industrial arts building in 2017.
At 28-year-old Diegueno Middle School, $24.3 million in improvements will begin this summer with parking lot and traffic circulation improvements. Work will continue in 2017 with classroom expansions and a new science and multipurpose room.
At Canyon Crest Academy — the district's youngest school, at only six years old — $33.9 million in improvements will begin this year when the campus loses some land at its east end to make way for a planned middle school. In exchange, Canyon Crest will expand to the west and get new baseball fields, a grandstand and improvements to the track.


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Cardiovascular Disease
An internist specializing in diseases of the heart, lungs and blood vessels and manages complex cardiac conditions such as heart attacks and life-threatening, abnormal heartbeat rhythms.
Training Required:
Three years in internal medicine plus additional training and examination for certification in cardiovascular disease, clinical electrophysiology or interventional cardiology
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Raghunandan Dudda-Subramanya, MD
Cardiovascular Disease
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2309 Evesham Rd Fl 2 - Ste 201
Voorhees, NJ 08043
Primary Care Physician:
Cardiovascular Disease
Hospital Affiliations
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Preventive Cardiology
Board Certification
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Cardiovascular Disease
Doctor's Training & Faculty Appointment
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Asst Prof, Medicine
Drexel Univ Coll Med
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India, 2000
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Internal Medicine
Drexel Univ Affil Hosp
Philadelphia, PA 2003-2006*
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Boyds Wood Floors specializes in high quality oak flooring. Whether it is red oak flooring or a white oak flooring you are looking for, Boyds Wood Floors has it all.
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It is Boyds Wood Floors' objective to understand each client's individual needs and suggest solutions that result in "happy customers".
Boyds Wood Floors specializes in high quality oak flooring. Whether it is red oak flooring or white oak flooring you are looking for, Boyds Wood Floors has it all. The best thing about the solid oak wood flooring supplied and installed by Boyds Wood Floors is that it gets better with age, providing an enduring splendor to any room or space in which it is installed. To get the most from your flooring installation, our website provides an in depth guide for Choosing Your Oak Floor, Installing Your Oak Floor, Finishing Your Oak Floor, and Maintaining Your Oak Floor, ensuring you get the best value from your new purchase.
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Our goal is to provide our customers with the best, the best wood flooring contrator services and the best hardwood flooring products. We continue to drive forward with our dedication. Quoted : Piotr Szmit, Owner


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A basic theme of Remarque's novels is survival in the face of adverse political conditions. Whereas during the time of the "Third Reich" the heroes of his novels had been exiled just like Remarque himself, he now went inside the "Third Reich" itself. The result were his concentration camp novels Der Funke Leben [Spark of Life, 1952] and Zeit zu leben und Zeit zu sterben [A Time to Love and a Time to Die, 1954] which was published, in the same year, first in English translation in America and then in German. Since Remarque was still living in the United States when he wrote the novel, it was necessary for him to interview people who had experienced …
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Wagener, Hans. "Zeit zu leben und Zeit zu sterben". The Literary Encyclopedia. First published 10 October 2008
[http://www.litencyc.com/php/sworks.php?rec=true&UID=19777, accessed 02 July 2015.]


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Find hotels in Blackwood using the list and search tools below. Search for cheap and discounted hotel and motel rates in or near Blackwood, PA for your business or personal leisure travel. Explore the most favored Blackwood Pennsylvania hotel/motel rooms. Review the Blackwood hotel list below to find the perfect lodging. We also have a map of the Blackwood hotels.The Blackwood center point is approximately 19 miles from Knoebels Amusement Resort and 23 miles from Lebanon Valley College.
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How to survive the Dakar
A beginners guide to spectating at the world's most demanding endurance competition
Posted: 22 Jan 2014
We're not going to fuel up in Monte Coman. It's a one-garage town and the only garage is for the exclusive use of the Dakar race bikes and quads. It's a good sight though, so Robert dives out cameras clattering (well, he is a photographer) to capture the dust and chaos of 200-odd bikes trying to use four pumps at the same time. Uwe is impatient. He wants to get to press location 2, our chosen viewpoint for the day. I volunteer to go and pull Robert out. Somewhere we miss each. Now everyone is looking for me. 15 minutes later we're all back at the car. Uwe is tearing is hair out. That's OK, he's got a good thatch.
Turns out Monte Coman is a two-garage town. Whooppee! Even with Uwe driving 500km of fuel should get us through the rest of the day.
We're heading due south on the 179. The good roads seem to have run out and bad roads in Argentina are both temptingly clear and straight and packed full on unseen potholes that explode under the wheels like mines. At times it's actually better to drive on the dirt at the side of the road than on the patchwork tarmac itself.
Having to drive slowly raises another issue. It's a cloudless 38 degrees outside. Four blokes may fit in a Mini Countryman, but they sure as hell force the air con to work hard. It's not capable of the necessary feat. Robert's in the front and likes to have the window down. He's like the bloke on the aeroplane in front of you who reclines his seat. Giovanni and I suffer in the draught until the map and some other random papers that we're planning to wave out the window as 'credentials' gust up into the air. There's a light border skirmish between front and back seats.
After 30 minutes of heading south amid arid fields with desert just beyond, we can see waving flags and banners in the distance. Odd, since my calculations show the press location is still 35km further on. It does at least show we're going the right way. We draw up beside a man wearing desert fatigues.
We don't have the right passes. Well, we don't have any proper accreditation as the race organisers charge thousands of euros for it and we thought we'd be able to wing it since we were with the X-Raid team and allowed in the campsite. Mistake. Basically we need more stickers on the side of the car. I get out of the car and try to reason with the obstinate Frenchman in his own lingo. I probably asked him for his aunt's pen or his uncle's desk or something. Uwe joins me. He tries the other method: speaking loudly and slowly. In English. Oh god. Obstinacy turns to aggression. A jabbing finger isn't far away when I take Uwe by the arm and steer him gently back to the Mini.
We've lost at least an hour and there's no other way of getting to where we want to go. Well, there is, but I reckon it's at least 180 miles round. Instead we spot another potential viewpoint...
We barrel back north, hitting all the same potholes we hit on the way south.


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Breaking Upwards' follows a young, real-life New York couple in a fictional narrative loosely inspired by their open relationship. After four years together, the two have grown stifled. Desperate to escape their ennui, but fearful of life apart, they decide to intricately strategize their own break up. Based on an actual experiment in real-life devised by filmmakers and partners, Daryl Wein and Zoe Lister-Jones, the film interprets a year in their lives exploring alternatives to monogamy, and the madness that ensues. The couple inhabits a hyper-articulate, emotionally layered world where twenty-somethings are portrayed in a complex and thoughtful new light. An uncensored look at young love, lust, and the pangs of codependency, 'Breaking Upwards' follows its characters as they navigate each others' emotions across the city they love. It begs the question: is it ever possible to grow apart together?
All Original Soundtrack on iTunes featuring the voices from the stars of the film.
© 2015 IFC in Theaters LLC. All Rights Reserved.


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FOR the first time, a mammal has been shown to be evolving in response to global warming. The discovery that red squirrels are adapting to climate change could bode well for other species struggling to acclimatise.
Recent studies have suggested that climate change is forcing many animals towards the cooler climes of the poles (
Now biologist Andrew McAdam and his colleagues at the University of Alberta in Canada have shown that some mammals may be able to evolve quickly enough to adapt. In work to appear in the
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AN unpatchable hole has appeared in a quantum cryptography technique that once seemed to promise an absolutely secure way to manipulate information. Although of no immediate practical importance, it shows the difficulty of guaranteeing security even with today's cutting-edge techniques.
Quantum cryptographers have long sought techniques that can be proved to be impervious to tampering or eavesdropping, says Richard Hughes of Los Alamos National Laboratory in New Mexico. One such "provably secure" method is quantum key distribution, in which the key to a code is sent as a pattern of photons, which any eavesdropper will be bound to disturb.
Recently, researchers have focused on a second technique, quantum bit commitment, which would let people compare or combine information while keeping each individual's contribution secret. This could be used, for example, to carry out dealings on the stock market without anyone being able to learn what others had bid.
Quantum bit ...
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Simon Inns builds this realtime PIC based audio spectrum analyzer. The analyzer uses Fast Fourier Transform routine written in C to run as efficient as possible on the 8 bit PIC18F4550 mcu. The output from the FFT is displayed using a 128×64 graphical LCD to allow a real-time view of an audio signal. [via]
PIC spectrum analyzer uses Fast Fourier Transform routine – [Link]
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Weve got a great selection of Natural Gemstones to choose from for your next jewelry or craft project. Shop for Natural Gemstones such as Almandine Garnet, Pearls, Peridot, Rhodolite Garnet and other beautiful gems. Enhance the value and beauty of your metal clay jewelry creations with Gemstones made by nature, or set them into your cast or fabricated jewelry. At Cool Tools you will find the top quality Natural Gemstones at amazingly affordable prices.


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Canon 320 Wifi setup
Wed, May 2, 2012 at 5:24 PM by undefined.
I got the
Canon 320
with wifi and of course immediately tried to set up the
wifi access
. The instructions in the manual are crap. They tell you to press buttons but they don't tell you where they are. And of course there's nothing like the buttons they describe on the camera or on any of the screens I was able to find. So far no luck.


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Professional Education
Doctor of Philosophy, University of California Irvine (2009)
Stanford Advisors
Thomas Sudhof, Postdoctoral Research Mentor
Brain-derived neurotrophic factor (BDNF) has emerged as a possible broad-spectrum treatment for the plasticity losses found in rodent models of human conditions associated with memory and cognitive deficits. We have tested this strategy in the particular case of ovariectomy. The actin polymerization in spines normally found after patterned afferent stimulation was greatly reduced, along with the stabilization of long-term potentiation, in hippocampal slices prepared from middle-aged ovariectomized rats. Both effects were fully restored by a 60-minute infusion of 2 nM BDNF. Comparable rescue results were obtained after elevating endogenous BDNF protein levels in hippocampus with 4 daily injections of a short half-life ampakine (positive modulator of ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionate [AMPA]-type glutamate receptors). These results provide the first evidence that minimally invasive, mechanism-based drug treatments can ameliorate defects in spine plasticity caused by depressed estrogen levels.
View details for DOI 10.1016/j.neurobiolaging.2010.06.008
View details for Web of Science ID 000301506800008
View details for PubMedID 20674095
Learning-induced neurotrophic signaling at synapses is widely held to be critical for neuronal viability in adult brain. A previous study provided evidence that unsupervised learning of a novel environment is accompanied by activation of the TrkB receptor for brain-derived neurotrophic factor (BDNF) in hippocampal field CA1b of adult rats. Here we report that this effect is regionally differentiated, in accord with "engram" type memory encoding. A 30 min exposure to a novel, complex environment caused a marked, NMDA receptor-dependent increase in postsynaptic densities associated with activated (phosphorylated) Trk receptors in rostral hippocampus. Increases were pronounced in field CA3a, moderate in the dentate gyrus, and absent in field CA1a. Synapses with Trk activation were significantly larger than their neighbors. Surprisingly, unsupervised learning had no effect on Trk phosphorylation in more temporal sections of hippocampus. It thus appears that commonplace forms of learning interact with regional predispositions to produce spatially differentiated effects on BDNF signaling.
View details for DOI 10.1523/JNEUROSCI.3549-10.2010
View details for Web of Science ID 000284096300025
View details for PubMedID 21068315
Reorganization of the actin cytoskeleton is essential for synaptic plasticity and memory formation. Presently, the mechanisms that trigger actin dynamics during these brain processes are poorly understood. In this study, we show that myosin II motor activity is downstream of LTP induction and is necessary for the emergence of specialized actin structures that stabilize an early phase of LTP. We also demonstrate that myosin II activity contributes importantly to an actin-dependent process that underlies memory consolidation. Pharmacological treatments that promote actin polymerization reversed the effects of a myosin II inhibitor on LTP and memory. We conclude that myosin II motors regulate plasticity by imparting mechanical forces onto the spine actin cytoskeleton in response to synaptic stimulation. These cytoskeletal forces trigger the emergence of actin structures that stabilize synaptic plasticity. Our studies provide a mechanical framework for understanding cytoskeletal dynamics associated with synaptic plasticity and memory formation.
View details for DOI 10.1016/j.neuron.2010.07.016
View details for Web of Science ID 000281534600010
View details for PubMedID 20797537
The abnormal spine morphology found in fragile X syndrome (FXS) is suggestive of an error in the signaling cascades that organize the actin cytoskeleton. We report here that physiological activation of the small GTPase Rac1 and its effector p-21 activated kinase (PAK), two enzymes critically involved in actin management and functional synaptic plasticity, is impaired at hippocampal synapses in the Fmr1-knock-out (KO) mouse model of FXS. Theta burst afferent stimulation (TBS) caused a marked increase in the number of synapses associated with phosphorylated PAK in adult hippocampal slices from wild-type, but not Fmr1-KO, mice. Stimulation-induced activation of synaptic Rac1 was also absent in the mutants. The polymerization of spine actin that occurs immediately after theta stimulation appeared normal in mutant slices but the newly formed polymers did not properly stabilize, as evidenced by a prolonged vulnerability to a toxin (latrunculin) that disrupts dynamic actin filaments. Latrunculin also reversed long-term potentiation when applied at 10 min post-TBS, a time point at which the potentiation effect is resistant to interference in wild-type slices. We propose that a Rac>PAK signaling pathway needed for rapid stabilization of activity-induced actin filaments, and thus for normal spine morphology and lasting synaptic changes, is defective in FXS.
View details for DOI 10.1523/JNEUROSCI.1077-10.2010
View details for Web of Science ID 000281197900003
View details for PubMedID 20720104
Learning-induced trophic activity is thought to be critical for maintaining health of the aging brain. We report here that learning, acting through an unexpected pathway, activates synaptic receptors for one of the brain's primary trophic factors. Unsupervised learning, but not exploratory activity alone, robustly increased the number of postsynaptic densities associated with activated (phosphorylated) forms of BDNF's TrkB receptor in adult rat hippocampus; these increases were blocked by an NMDA receptor antagonist. Similarly, stimulation of hippocampal slices at the learning-related theta frequency increased synaptic TrkB phosphorylation in an NMDA receptor-dependent fashion. Theta burst stimulation, which was more effective in this regard than other stimulation patterns, preferentially engaged NMDA receptors that, in turn, activated Src kinases. Blocking the latter, or scavenging extracellular TrkB ligands, prevented theta-induced TrkB phosphorylation. Thus, synaptic TrkB activation was dependent upon both ligand presentation and postsynaptic signaling cascades. These results show that afferent activity patterns and cellular events involved in memory encoding initiate BDNF signaling through synaptic TrkB, thereby ensuring that learning will trigger neurotrophic support.
View details for DOI 10.1073/pnas.0912973107
View details for Web of Science ID 000276642100084
View details for PubMedID 20356829
Estrogen, in addition to its genomic effects in brain, causes rapid and reversible changes to synaptic operations. We report here that these acute actions are due to selective activation of an actin-signaling cascade normally used in the production of long-term potentiation (LTP). Estrogen, or a selective agonist of the steroid's beta-receptor, caused a modest increase in fast glutamatergic transmission and a pronounced facilitation of LTP in adult hippocampal slices; both effects were completely eliminated by latrunculin, a toxin that prevents actin filament assembly. Estrogen also increased spine concentrations of filamentous actin and strongly enhanced its polymerization in association with LTP. A search for the origins of these effects showed that estrogen activates the small GTPase RhoA and phosphorylates (inactivates) the actin severing protein cofilin, a downstream target of RhoA. Moreover, an antagonist of RhoA kinase (ROCK) blocked estrogen's synaptic effects. Estrogen thus emerges as a positive modulator of a RhoA>ROCK>LIM kinase>cofilin pathway that regulates the subsynaptic cytoskeleton. It does not, however, strongly affect a second LTP-related pathway, involving the GTPases Rac and Cdc42 and their effector p21-activated kinase, which may explain why its acute effects are reversible. Finally, ovariectomy depressed RhoA activity, spine cytoskeletal plasticity, and LTP, whereas brief infusions of estrogen rescued plasticity, suggesting that the deficits in plasticity arise from acute, as well as genomic, consequences of hormone loss.
View details for DOI 10.1523/JNEUROSCI.3059-09.2009
View details for Web of Science ID 000270845000033
View details for PubMedID 19828812
The releasable factor adenosine blocks the formation of long-term potentiation (LTP). These experiments used this observation to uncover the synaptic processes that stabilize the potentiation effect. Brief adenosine infusion blocked stimulation-induced actin polymerization within dendritic spines along with LTP itself in control rat hippocampal slices but not in those pretreated with the actin filament stabilizer jasplakinolide. Adenosine also blocked activity-driven phosphorylation of synaptic cofilin but not of synaptic p21-activated kinase (PAK). A search for the upstream origins of these effects showed that adenosine suppressed RhoA activity but only modestly affected Rac and Cdc42. A RhoA kinase (ROCK) inhibitor reproduced adenosine's effects on cofilin phosphorylation, spine actin polymerization, and LTP, whereas a Rac inhibitor did not. However, inhibitors of Rac or PAK did prolong LTP's vulnerability to reversal by latrunculin, a toxin which blocks actin filament assembly. Thus, LTP induction initiates two synaptic signaling cascades: one (RhoA-ROCK-cofilin) leads to actin polymerization, whereas the other (Rac-PAK) stabilizes the newly formed filaments.
View details for DOI 10.1083/jcb.200901084
View details for Web of Science ID 000267939500009
View details for PubMedID 19596849
Recent demonstrations that positive modulators of AMPA-type glutamate receptors (ampakines) increase neuronal brain-derived neurotrophic factor (BDNF) expression have suggested a novel strategy for treating neurodegenerative diseases. However, reports that AMPA and BDNF receptors are down-regulated by prolonged activation raise concerns about the extent to which activity-induced increases in BDNF levels can be sustained without compromising glutamate receptor function. The present study constitutes an initial test of whether ampakines can cause enduring increases in BDNF content and signaling without affecting AMPA receptor (AMPAR) expression. Prolonged (12-24 h) treatment with the ampakine CX614 reduced AMPAR subunit (glutamate receptor subunit (GluR) 1-3) mRNA and protein levels in cultured rat hippocampal slices whereas treatment with AMPAR antagonists had the opposite effects. The cholinergic agonist carbachol also depressed GluR1-3 mRNA levels, suggesting that AMPAR down-regulation is a global response to extended periods of elevated neuronal activity. Analyses of time courses and thresholds indicated that BDNF expression is influenced by lower doses of, and shorter treatments with, the ampakine than is AMPAR expression. Accordingly, daily 3 h infusions of CX614 chronically elevated BDNF content with no effect on GluR1-3 concentrations. Restorative deconvolution microscopy provided the first evidence that chronic up-regulation of BDNF is accompanied by increased activation of the neurotrophin's TrkB-Fc receptor at spine synapses. These results show that changes in BDNF and AMPAR expression are dissociable and that up-regulation of the former leads to enhanced trophic signaling at excitatory synapses. These findings are encouraging with regard to the feasibility of using ampakines to tonically enhance BDNF-dependent functions in adult brain.
View details for DOI 10.1016/j.neuroscience.2008.12.018
View details for Web of Science ID 000263863500029
View details for PubMedID 19141314
Estrogen, in addition to its genomic effects, triggers rapid synaptic changes in hippocampus and cortex. Here we summarize evidence that the acute actions of the steroid arise from actin signaling cascades centrally involved in long-term potentiation (LTP). A 10-min infusion of E2 reversibly increased fast EPSPs and promoted theta burst-induced LTP within adult hippocampal slices. The latter effect reflected a lowered threshold and an elevated ceiling for the potentiation effect. E2's actions on transmission and plasticity were completely blocked by latrunculin, a toxin that prevents actin polymerization. E2 also caused a reversible increase in spine concentrations of filamentous (F-) actin and markedly enhanced polymerization caused by theta burst stimulation (TBS). Estrogen activated the small GTPase RhoA, but not the related GTPase Rac, and phosphorylated (inactivated) synaptic cofilin, an actin severing protein targeted by RhoA. An inhibitor of RhoA kinase (ROCK) thoroughly suppressed the synaptic effects of E2. Collectively, these results indicate that E2 engages a RhoA >ROCK> cofilin> actin pathway also used by brain-derived neurotrophic factor and adenosine, and therefore belongs to a family of 'synaptic modulators' that regulate plasticity. Finally, we describe evidence that the acute signaling cascade is critical to the depression of LTP produced by ovariectomy.
View details for PubMedID 20419049
Recent work has added strong support to the long-standing hypothesis that the stabilization of both long-term potentiation and memory requires rapid reorganization of the spine actin cytoskeleton. This development has led to new insights into the origins of cognitive disorders, and raised the possibility that a diverse array of memory problems, including those associated with diabetes, reflect disturbances to various components of the same mechanism. In accord with this argument, impairments to long-term potentiation in mouse models of Huntington's disease and in middle-aged rats have both been linked to problems with modulatory factors that control actin polymerization in spine heads. Complementary to the common mechanism hypothesis is the idea of a single treatment for addressing seemingly unrelated memory diseases. First tests of the point were positive: Brain-Derived Neurotrophic Factor (BDNF), a potent activator of actin signaling cascades in adult spines, rescued potentiation in Huntington's disease mutant mice, middle-aged rats, and a mouse model of Fragile-X syndrome. A similar reversal of impairments to long-term potentiation was obtained in middle-aged rats by up-regulating BDNF production with brief exposures to ampakines, a class of drugs that positively modulate AMPA-type glutamate receptors. Work now in progress will test if chronic elevation of BDNF enhances memory in normal animals.
View details for DOI 10.1016/j.ejphar.2007.11.082
View details for Web of Science ID 000256149300002
View details for PubMedID 18374328
Mice lacking expression of the fragile X mental retardation 1 (Fmr1) gene have deficits in types of learning that are dependent on the hippocampus. Here, we report that long-term potentiation (LTP) elicited by threshold levels of theta burst afferent stimulation (TBS) is severely impaired in hippocampal field CA1 of young adult Fmr1 knock-out mice. The deficit was not associated with changes in postsynaptic responses to TBS, NMDA receptor activation, or levels of punctate glutamic acid decarboxylase-65/67 immunoreactivity. TBS-induced actin polymerization within dendritic spines was also normal. The LTP impairment was evident within 5 min of induction and, thus, may not be secondary to defects in activity-initiated protein synthesis. Protein levels for both brain-derived neurotrophic factor (BDNF), a neurotrophin that activates pathways involved in spine cytoskeletal reorganization, and its TrkB receptor were comparable between genotypes. BDNF infusion had no effect on baseline transmission or on postsynaptic responses to theta burst stimulation, but nonetheless fully restored LTP in slices from fragile X mice. These results indicate that the fragile X mutation produces a highly selective impairment to LTP, possibly at a step downstream of actin filament assembly, and suggest a means for overcoming this deficit. The possibility of a pharmacological therapy based on these results is discussed.
View details for DOI 10.1523/JNEUROSCI.2624-07.2007
View details for Web of Science ID 000249981400006
View details for PubMedID 17913902
Stabilization of long-term potentiation (LTP) is commonly proposed to involve changes in synaptic morphology and reorganization of the spine cytoskeleton. Here we tested whether, as predicted from this hypothesis, induction of LTP by theta-burst stimulation activates an actin regulatory pathway and alters synapse morphology within the same dendritic spines. TBS increased severalfold the numbers of spines containing phosphorylated (p) p21-activated kinase (PAK) or its downstream target cofilin; the latter regulates actin filament assembly. The PAK/cofilin phosphoproteins were increased at 2 min but not 30 s post-TBS, peaked at 7 min, and then declined. Double immunostaining for the postsynaptic density protein PSD95 revealed that spines with high pPAK or pCofilin levels had larger synapses (+60-70%) with a more normal size frequency distribution than did neighboring spines. Based on these results and simulations of shape changes to synapse-like objects, we propose that theta stimulation markedly increases the probability that a spine will enter a state characterized by a large, ovoid synapse and that this morphology is important for expression and later stabilization of LTP.
View details for DOI 10.1523/JNEUROSCI.0164-07.2007
View details for Web of Science ID 000246720600011
View details for PubMedID 17507558
Brain-derived neurotrophic factor (BDNF) is an extremely potent, positive modulator of theta burst induced long-term potentiation (LTP) in the adult hippocampus. The present studies tested whether the neurotrophin exerts its effects by facilitating cytoskeletal changes in dendritic spines. BDNF caused no changes in phalloidin labeling of filamentous actin (F-actin) when applied alone to rat hippocampal slices but markedly enhanced the number of densely labeled spines produced by a threshold level of theta burst stimulation. Conversely, the BDNF scavenger TrkB-Fc completely blocked increases in spine F-actin produced by suprathreshold levels of theta stimulation. TrkB-Fc also blocked LTP consolidation when applied 1-2 min, but not 10 min, after theta trains. Additional experiments confirmed that p21 activated kinase and cofilin, two actin-regulatory proteins implicated in spine morphogenesis, are concentrated in spines in mature hippocampus and further showed that both undergo rapid, dose-dependent phosphorylation after infusion of BDNF. These results demonstrate that the influence of BDNF on the actin cytoskeleton is retained into adulthood in which it serves to positively modulate the time-dependent LTP consolidation process.
View details for DOI 10.1523/JNEUROSCI.4037-06.2007
View details for Web of Science ID 000245103600032
View details for PubMedID 17360925


text:
Statement of Significance (as of designation - July 4, 1961):
Discovered by explorer Zebulon Pike in 1806, though long familiar to Indians and Spaniards, the peak has an elevation of 14,110 feet. It was first climbed in 1820. During the 19th century, "Pike's Peak or Bust" became a familiar rallying cry for those heading west, and over the years it has assumed the role of a virtual icon of western exploration and settlement.
There are no threats to the landmark.
There are no changes indicated
Comments and questions about the database may be directed to firstname.lastname@example.com


text:
CHIPLEY — The floods of the past summer caused of millions of dollars of damage to Washington County infrastructure, and when rainwater leaked into the county courthouse, it alerted officials to problems that led to the building's condemnation.
Not long after officials noticed the standing water in the basement, they also began to notice problems with the exterior of the building. Then, a roughly 800-pound chunk of stone fell from the top of the courthouse. Then they found rotten wood, water damage, peeling paint and mold.
"We got back at least a dozen different strains of mold, five of which were deemed to be immediate health risks," said Circuit Judge Christopher Patterson, who spearheads a committee tasked with solving the courthouse dilemma.
When air quality tests of the Washington County Courthouse came back in December, officials shut it down and moved into temporary locations at an annex next door that also houses the Sheriff's Office and the county building a few blocks away.
The move resolved health concerns, but it created a raft of new problems. Evidence in criminal cases had to be relocated, as did tens of thousands of official records, some of which were coated with a visible layer of mold and will need to be cleaned.
"People are safe. We don't have any immediate risk, except for people who may walk by that courthouse and things fall on their head," Patterson said. "And I'm not being facetious."
Security concerns
The move also created security concerns because the new digs were never intended for holding court, at least not felony criminal court. Judges wait outside in their cars before taking the bench because there are no chambers. Prisoners wait for their hearings locked in the back of squad cars because there are no holding cells.
"We are in a wonderfully more secure place than we were a month ago," Patterson said. "We're making good progress."
Court workers have scrambled to install locks, cameras and other security measures to at least reduce the risk, but Patterson, who earlier this month locked himself in a bathroom because he had nowhere else to wait for attorneys and a defendant in a criminal case to enter the courtroom, said in an interview that, under the current circumstances, it's not a matter of if security will be breached; it's a matter of when.
Certain aspects of the transition to what officials hope is a temporary courtroom next door in the Sheriff's Office have been relatively simple. Transferring computers, phones, metal detectors and other equipment was accomplished quickly, but moving a holding cell to secure prisoners waiting to see a judge? That's not happening, and it's causing security risks for everyone involved.
"Most everyone who's in custody is appearing via video from the jail with their attorney there at the jail with them," said County Judge Colby Peel. But, he said, eventually a trial requires the defendant to be "present in the courtroom, so that's what we're struggling with right now."
'Skin in the game'
That's not the only struggle
An architect estimated it would cost more than $4.75 million to renovate the old courthouse and more than $8.8 million to build a new, 30,000-square-foot facility with two courtrooms.
"I believe that the county is going to have to put some skin in this game," said County Attorney Jeff Goodman. "We're not going to walk with our hat to
That will be a problem for
"Our initial plan was to pay for this ourself, but it just exploded on us," Goodman said.
Officials are discussing increasing the surcharge on traffic citations by $30, but even that would generate only about $115,000 a year, said interim Clerk of Courts Harold Bazzel.
Bazzel said he thinks the only way the county could raise the money would be to increase property taxes, but he didn't expect that idea to be popular with county commissioners, especially in an election year.
'No guarantees'
Republican State Rep. Marti Coley, whose district includes
"They are exploring different ways to help themselves, and we are going to explore different ways that we can help them," Coley said.
She said her staff is exploring potential funding sources from the state for the project, but there is no guarantee the funding will be included in an appropriations bill this year.
Members of the steering committee also have met with Rep. Matt Gaetz,
"I think they fully understand all the issues," said Jan Shadburn, trial court administrator for the 14th Judicial Circuit.
Patterson said the committee needed to have its ducks in row by the opening of the legislative session in early March. For now, only one thing is certain.
"We can't go back to that courthouse, based on what we now know," Patterson said during the steering committee's most recent meeting. "It is such a health risk that there's nobody in this room that would want to put the general public back in there."


text:
The Zondervan Encyclopedia of the Bible, Volume 3: Revised Full-Color Edition / New edition - eBook
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Product Information
|Format: DRM Protected ePub
Vendor: Zondervan
Publication Date: 2010
Availability: In Stock
Publisher's Description
Revised edition. Volume 3 of 5. The Zondervan Encyclopedia of the Bible has been a classic Bible study resource for more than thirty years. Now thoroughly revised, this new five-volume edition provides up-to-date entries based on the latest scholarship. Beautiful full-color pictures supplement the text, which includes new articles in addition to thorough updates and improvements of existing topics. Different viewpoints of scholarship permit a wellrounded perspective on significant issues relating to doctrines, themes, and biblical interpretation. The goal remains the same: to provide pastors, teachers, students, and devoted Bible readers a comprehensive and reliable library of information. More than 5,000 pages of vital information on Bible lands and people More than 7,500 articles alphabetically arranged for easy reference Hundreds of full-color and black-and-white illustrations, charts, and graphs 32 pages of full-color maps and hundreds of black-and-white outline maps for ready reference Scholarly articles ranging across the entire spectrum of theological and biblical topics, backed by the most current body of archaeological research 238 contributors from around the world
Author Bio
Merrill C. Tenney was professor of theological studies and dean of the Graduate school of Theology at Wheaton College, where he taught from 1944 to 1982. In addition to teaching New Testament and Greek, he was the general editor of the Zondervan Pictorial Bible Dictionary, served on the original translation team for the New American Standard Bible, and wrote several books. Tenney was an advocate of fundamentalism and a second president of the Evangelical Theological Society. He was born in Massachusetts and received his education from Nyack Missionary Training Institute, Gordon College of Theology and Missions, Boston University, and Harvard University. He and his wife Helen and two sons.
Moisés Silva taught biblical studies at Westmont College, Westminster Theological Seminary, and Gordon-Conwell Seminary. He is the author or coauthor of eight books and the revising editor of the Zondervan Encyclopedia of the Bible.


text:
BD: Oh my! Bigger is most certainly better, and McCoy vs Gillz is a superstar match-up!
PK: Staples can't do that! That's putting the champ In a seriously detrimental environment only a few days from a title defence, it's insanity!
BD: It's justice, he got a chance to be the referee a match between the two, and turned it into chaos.
PK: He has every right to! He's the bad guy Bob, we would be bored out of our minds without Gillz in this feud, it'd be full of "respect" and "admiration".
BD: You have a point.
PK: I always do, maybe you should listen to me a little more intently Bob, I am wise.
BD: Wise is pushing it, but anyway here we go, McCoy vs Gillz!
(Gillz = Punk / McCoy = Kane)
BD: Where is Gillz going?
PK: He's making a point. This match has no meaning, and he doesn't need to risk any injury before Vendetta.
BD: I just think he's scared.
PK: The champ ain't scared of anyone, he doesn't want to waste time with people he's not even going to face in a while.
BD: That's disrespectful to McCoy, who really had the champ beaten.
PK: You don't get it Bob, he's the champ, he can do as he pleases.


text:
Advanced Math/Science Research Update
by Dr. April Burch, Director of the AMSR program
January 15, 2013
Since our last update, Berkshire School hosted student researchers from Belmont Hill, and all-boys prep school outside of Boston, for a 1-day mini-symposium on Student Biomedical Research. The goal was to foster collaboration, communication and community outreach with our students. AMSR students Liza Bernstein '13, Sissi Wang '13, Lars Robinson '13, Elsie Guevara '13, Ernest Yue '13, and Nate MacKenzie '14, gave short talks about their work in the new Bellas/Dixon Math and Science lecture hall. The talks were followed up by break-out sessions where Belmont Hill students described their research projects and students discussed commonalities between the projects and future goals.
The second semester of AMSR started with some terrific news. The AMSR program was awarded a grant from The Chinchester Dupont Foundation for the purchase of an EVOS fluorescence microscope. This piece of equipment will expand the types of experiments and analyses that can be done by AMSR students this and future years. The microscope should arrive shortly, and Dr. Burch has invited everyone to stop in for a look next time they are on campus.
One new, exciting project that is underway in the winter season of AMSR in the afternoons is being spearheaded by Elif Kesaf '14. Elif is from Turkey and seeks to identify novel viruses of non-pathogenic strains of Legionella bacterium from travertines in Pamukkale. In collaboration with Dr. Sunny Shin at the Perlman School of Medicine at the University of Pennsylvania, she will be working to isolate viruses of this bacterium with the hope of identifying new agents to combat Legionnaires' disease caused by a pathogenic form of Legionella.
Look for more news from Dr. Burch in the next issue!
Advanced Math/Science Research
The Berkshire School Advanced Math/Science Research students had their first visits to their respective research sites this week. Each student works with a professional researcher at some of the top research institutions in the United States. Last year, eighteen students were in the course, including three who entered the INTEL Science Talent Search Competition, the nation's most prestigious science research competition for high school seniors; Jenny Quilty '11 was an INTEL Semifinalist, the second Berkshire student in two years to earn that distinction. This year there are twenty students in the course, eight of whom will enter the INTEL contest. No other independent boarding school in the United States will have as many entrants.
"We are really excited about this year's group," said course instructor and Math Department Chair Kurt Schleunes. "In addition to having students at the College of Nanoscale Science and Engineering, SUNY, Albany Medical Center, and Wadsworth Medical Center, we have placed students at Williams College and Amherst College. In addition, two students will be doing mathematical research with our new math teacher, Dr. Tim Lance, here on campus. This is, without a doubt, the finest group of students I have worked with in my 29-year career in teaching."
"This year we have a nice mix of American and International students. When our students go to the lab, they have the opportunity to work with a team of scientists from all over the world. They are able to succeed in this setting because they are part of a global community at Berkshire; our students come from twenty-five countries and twenty-four states. Another reason is that they play team sports here at Berkshire. Learning to work with or lead a team of people from diverse backgrounds is an important skill, and Berkshire School is deeply committed to developing such life skills in our students."
Click here to view the this year's list of students and mentors.
Click here to learn more about Advanced Math/Science Research at Berkshire.


text:
The following is an archive of a post made to our
'vox mailing list'
by one of its subscribers.
On Tue, Jun 10, 2003 at 08:20:09PM -0700, Bill Kendrick wrote:
> On Tue, Jun 10, 2003 at 06:38:56PM -0700, Jeff Newmiller wrote:
> >
> > a) My company asks me to install a kiosk in our front lobby. I modify
> > GPL code to get it working. Is physical access to a device
> > implemented with GPL'd tools by the public considered "distribution"?
> I think so, hence the source-code releases by folks like TiVo and
> Dish Network.
But you actually *buy* TiVo, etc. He's talking about physical access,
but not ownership; not even leasing. I don't think there's a court in
the world that would rule this to be "distribution."
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text:
Click here for the 2013 Leadoff Dinner RSVP Card
WORCESTER, Mass. - Holy Cross baseball head coach Greg DiCenzo and the rest of the 2013 baseball team will host the ninth annual Leadoff Dinner on Saturday, Feb. 2 beginning at 5:30 p.m. in the Hogan Campus Center Ballroom. This year's event will have current Portland Sea Dogs hitting coach and Worcester native, Rich Gedman, as well as honored guest Pete Frates.
Gedman enters his first season as the Sea Dogs' hitting coach. He served in the same capacity for the Salem Red Sox in 2012 and the Lowell Spinners in 2011. Previously, he managed six seasons for the Worcester Tornadoes (2005-2010) in the independent Can-Am League. Before managing Worcester, Gedman served as the bench coach for the Can-Am League's North Shore Spirit. A native of Worcester, Mass., Gedman signed with the Red Sox as an undrafted free agent in 1977 and played 13 seasons in the Major Leagues with the Red Sox (1980-1990), Houston Astros (1990) and St. Louis Cardinals (1991-1992). A career .252 hitter with 88 home runs and 382 RBIs, he earned a pair of All-Star selections in 1985 and 1986. He was the Red Sox catcher for the 1986 American League pennant run, and caught Roger Clemens' first 20-strikeout game on April 29, 1986.
Frates grew up in Beverly, Mass. and attended St. John's Preparatory School '03 and Boston College '07. At St. John's Prep, he was a four-year member of the football, hockey and baseball teams, a school leader and an honor roll student. At Boston College he majored in communications and history, lived on campus and played for the BC baseball team becoming its captain in his senior year. During his college years, he played summer ball in Maryland, Connecticut and Hawaii. After college, he went to Hamburg, Germany to play baseball in the German Baseball League while coaching German youth on the sport. He was recently diagnosed with Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease and is involved with the Pete Frates #3 Fund.
The event will begin at 5:30 p.m. with a social hour and cash bar, followed by a buffet dinner at 6:30 p.m. Members of the 2013 Holy Cross baseball team and their families will be in attendance along with many alumni and friends.
Tickets for the dinner are $100 per person or $75 for Holy Cross alumni and friends from classes 2007-2012. All proceeds will directly fund this year's spring trips. In order to reserve a ticket, please fill out the registration form and send to Holy Cross Athletics by Friday, Jan. 25. For further information on the dinner, please contact Jennifer Whipple at (508) 793-3583 or email@example.com.


text:
Looking for a new pet and a great vet? Come out to Texas Veterinary Hopsital at 3493 Fredericksburg Road this Saturday. Animal Care Services will have the adoption mobile on site with lots of dogs and puppies looking for new homes. Come by and see us from 10am-3pm. Adoption fees are just $50 and include your new pet's sterilization, microchip, city license and vaccinations.
Animal Care Services
Join Animal Care Services and its partners as we strive to provide every healthy and adoptable pet in this community hope for a "forever" home with responsible owners.
ACS teams up with Vet Clinic for adoption event
One Response
[…] Article from http://blog.mysanantonio.com/animalcare/2012/04/acs-teams-up-with-vet-clinic-for-adoption-event/ACS teams up with Vet Clinic for adoption […]


text:
Department of Neurology
School of Medicine > Neurology > Residency > Residency Training Program > Facilities
School of Medicine > Neurology > Residency > Residency Training Program > Facilities
Our residents work in four different health care facilities in the region, each of which provides a unique training opportunity.
The University of Kansas Hospital is a more than 650-bed hospital that is the major teaching hospital for the University of Kansas Medical Center (KUMC) and for the Department of Neurology. It is the secondary and tertiary referral center for the state of Kansas and a level one trauma center. Patients come from the entire state of Kansas, western Missouri, eastern Nebraska, eastern Oklahoma, and northern Arkansas. The hospital recently added three new floors to its Center for Advanced Heart Care, with the 32-bed Neurology ward on the eighth floor and the 24-bed Neurological-Neurosurgical ICU on the ninth floor. Six video-EEG machines are used for prolonged monitoring. The nurses on these wards are trained in the care of patients with neurological disorders and are part of the Stroke Rapid Response assessment team. A new Cambridge Tower is scheduled to open in 2016. It is set to house Neurology, Neurosurgery and ENT. While connected to the main hospital by a bridge, this building will have a dedicated neuroimaging suite, with interventional radiology, operating rooms and the NICU.
The main location for the Department of Neurology is in the Theo and Alfred M. Landon Center on Aging, one block north of the main hospital campus. Most of our faculty are housed in this building. We average 1,175 outpatient visits each month utilizing 24 clinic rooms, two EMG machines, two combined EMG/EEG/evoked potential laboratories, a procedure room for muscle and skin biopsies, and an infusion center for chemotherapy and plasmaphsresis. A three-bed unit for sleep studies is housed nearby in the Clinical and Translational Science Unit.
The School of Medicine's main classrooms are on the campus along with the School of Nursing and the School of Health Professions. These include the Physical Therapy, Occupational Therapy, Pharmacy, and the Master's programs in Pubic Health and in Clinical Science.
The Kansas City Veterans Administration Medical Center is a 125-bed facility acute care hospital designed to serve our veterans. Our service provides neurology consults and staff the neurology clinics. Intensive care for neurology patients is available in the medical intensive care unit (MICU), coronary care unit (CCU), and surgical intensive care unit (SICU) as needed under the primary supervision of pulmonary/critical care or cardiology staff physicians. Outpatient evaluations are conducted in the Silver Clinic, which provides eight well-equipped rooms. There are three rooms for EMG/NCV studies and two rooms for EEG and evoked potential studies. Clinics are held five half-days each week.
Located in nearby historic Leavenworth, the Leavenworth Veterans Administration Medical Center is a 75-bed acute care facility with a large domicile area for veterans with chronic illness. The neurology service is primarily inpatient consults, clinic, and clinical neurophysiology.
Children's Mercy Hospital is a 296-bed children's hospital located five miles away from our main campus, in Kansas City, Missouri. It is the main teaching hospital for our sister program in Pediatric Neurology. This hospital serves as the secondary and tertiary referral center for pediatric patients for Kansas, western Missouri, and eastern Nebraska. The pediatric neurology team consists of 12 faculty pediatric neurologists, pediatric neurology fellows, an adult neurology resident, a pediatric resident, and a variable number of medical students. Inpatients are primarily managed by the pediatric ward services, with the neurology team providing consults, ED evaluation, and an active outpatient service.


text:
tobacco zucca canvas 'Bauletto C' convertible crossbody bag
designer's notes
For timeless classics and cutting edge styles, explore the best of both worlds with Italian luxury fashion house, Fendi.
color: Tobacco / Brown Zucca patterned canvas with leather accents and polished goldtone hardware Top zip closure Dual 12�'' top handles with 6'' drop Removable adjustable crossbody strap measures 46'' with a 25'' drop Logo jacquard lining with interior patch pocket Measures approximately 12'' at widest x 9'' tall at center x 7'' deep; weighs 1.5 lbs. Fendi style #8BL108 Canvas / Leather; Italy; style# 320485201


text:
The following is an archive of a post made to our
'vox mailing list'
by one of its subscribers.
On Thu, Mar 03, 2005 at 12:41:10PM -0800, Jeff Newmiller wrote:
> On Thu, 3 Mar 2005, Richard S. Crawford wrote:
> > And behold, Micah Cowan flailed at a keyboard and did expound:
> >
> > > The exception to this could be if a faulty video driver hung. But
> > > of course, if this happened to Windows, you wouldn't be able to
> > > get a task manager, either. :-)
> >
> > Yes, this is true. I hadn't thought of that. But even if my Linux
> > box had a faulty video driver, I'd still be able to SSH into it to
> > examine the situation pretty easily.
> As someone who has had to cope with exactly such problems in Linux, I
> can assure you that you are wrong.
> Bugs in ANY kernel code can bring your trusty Linux box to a
> screeching halt... completely.
Yes, but the discussion is about crashes related to X, not the kernel.
The point is that even if X freezes hard, the solution that Richard
mentions is a viable approach to recover without rebooting (granted that
networking is up, sshd is running, and one has a spare system to login
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Becoming an Athletic Trainer
What is an Athletic Trainer?
Athletic Trainers (ATs) are health care professionals who collaborate with physicians. The services provided by ATs comprise prevention, emergency care, clinical diagnosis, therapeutic intervention and rehabilitation of injuries and medical conditions.
Click here to find out more about the profession of Athletic Training.
How do I qualify to become an Athletic Trainer?
To become an athletic trainer, candidates must graduate with a degree in Athletic Training from an accredited athletic training program and successfully pass the Board of Certification (BOC) Exam. To practice as an athletic trainer in most states, the individual must also be credentialed within the state. To search for institutions with programs to prepare graduates to become athletic trainers, search for Professional Programs. Degrees in physical therapy, exercise science, strength and conditioning or others DO NOT qualify the candidate to sit for the BOC examination.
Professional Programs lead to eligibility to sit for the Board of Certification examination and to enter the profession of athletic training. Professional Programs are available at both the baccalaureate and post-baccalaureate degree levels
If you are already a licensed/certified athletic trainer and looking for more education, you will need to look for Post-Professional Degree Programs or Post Professional Residency Program.
Post-Professional Degree Programs lead to a degree (masters or doctorate) for learners that are already credentialed as athletic trainers and expand the depth and breadth of the applied, experiential, and propositional knowledge and skills of athletic trainers through didactic, clinical, and research experiences. These programs DO NOT qualify the learner to sit for the BOC exam.
Post-Professional Residency Programs are formal educational programs that offer structured curricula, including didactic and clinical components, to educate Athletic Trainers. They are designed to build upon and expand the Athletic Trainer's knowledge and experience acquired during professional (entry-level) education.
Search for accredited Athletic Training Programs.
What factors I should take into consideration when choosing an Athletic Training Program?
There are many factors that students (and parents) should consider when choosing a college or university for a degree in Athletic Training. Listed below are a few questions that prospective students and their parents should ask when trying to choose a college/university to study athletic traini
- Is the program accredited? Program MUST be accredited for graduates to sit for the BOC exam
- How successful are the program's graduates on the BOC examination? Graduates of Athletic Training Professional Programs are eligible to sit for the Board of Certification (BOC) examination that serves as the credentialing examination for the profession. Each program MUST publish student outcomes data on their website. Click here to see a listing of all Professional Program 3-year BOC Pass Rate Results
- This includes:The number of students graduating from the program who took the examination, number and percentage of students who passed the examination on the first attempt, and overall number and percentage of students who passed the examination regardless of the number of attempts.
- Programs that do not meet or exceed a three year aggregate of 70 percent first-time pass rate on the BOC examination are in non-compliance with CAATE Standard 11.
- Although graduate's success on the BOC exam is just one indicator of the program's outcomes, passing the examination is a requirement to enter the profession so should be a consideration when a prospective student is choosing a program.
BOC pass rate across all programs
% First Time Pass Rate
Overall pass rate
Please note: these data are based on graduating cohorts across all accredited athletic training programs.
Other factors in choosing a Professional Program in Athletic Training
- In what college/department is the program located? Is the program housed with other health care professions? A big part of learning to be a health care professional is interacting with other health care professionals and students.
- What is the size and experience of the program faculty?
- What is the placement rate of the program's graduates? Do graduates find jobs in athletic training?
- Does the program offer a variety of clinical placements with athletic and non-athletic populations?


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This morning, some conservative groups expended a lot of energy hyping a document that seemed to show the Office of Management and Budget -- and hence the Obama administration -- opposes the Environmental Protection Agency's decision to classify carbon as a dangerous pollutant. That was a bad idea, because it's just given the OMB a high-profile opportunity to restate its support for the EPA's finding. Peter Orszag, the director of the OMB, explains. And he also links to this April 17th post where he calls the EPA's decision "important" and writes that "the proposed finding is carefully rooted in both law and science."
Either way, what actually happened today is that the OMB gave the EPA license to go forward with its reclassification of carbon. This would, in theory, give the EPA the ability to regulate carbon autonomously. If Congress fails to act on cap and trade, in other words, the EPA can do some of the job itself. And it may do it in ways that the energy industry finds less congenial. Orszag put this pretty explicitly back in April:
The President has made it clear that he wants to move the nation toward clean energy, and that part of that effort involves a legislative approach to reducing greenhouse gas emissions under a "cap and trade" program. Such a program would be more effective and efficient than most types of regulation. While such a program is being debated in the Congress, however, the Administration is following both the science and the law with regard to the Clean Air Act.
Sat, 2013-07-13 14:09
Vue 8 is usually a 99-years leasehold Seaview Pasir Ris house growth based inside the boat ended up houses enclave with Pasir Ris Heights. Vue 8 Home possesses total and exclusive amenities, which includes a safeguard property. Vue 8 pasir ris is additionally next to Town center Distance, the purchasing, food and entertainment centre which is scheduled in order to start with a couple of years moment. Amusement regarding your household and close friends usually are therefore close to hand with all the total house amenities as well as the services next to Vue8 Home. Vue 8 Residence are going to be readily available with Pasir Ris MRT Stop and also Pasir Ris Coach Interchange. It is additionally suitable next to Tampines Expressway(TPE).
eCoPolitan is usually a 99-year Leasehold account manager condominium based along Punggol Approach or Punggol Walk, with Center 21. eCoPolitan with punggol can includes 512 products. eCoPolitan ec can be next to near Punggol MRT Stop and Sengkang MRT Stop. Educational institutions which can be near eCoPolitan include, Compassvale Secondary School and Edgefield Primary School. People with Ecopolitan might get in order to community food markets or perhaps local mall inside the location regarding numerous services such as market and retail purchasing, banking companies, eateries and for example. eCoPolitan also are close to River Place.
Lush Acres Exec Condominium is in the junction connected with Sengkang West Approach and Fernvale Hyperlink, that dev't website is usually a small vanish in the Layar LRT. Luxurious Acres EC are going to be based along Seng Kang West Approach and Fernvale Hyperlink, giving a new condominium houses connected with 380 products. In view with the houses needs connected with potential Exec Residence house owners.
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Springfield College Child Development Center Receives National AccreditationMarch 12, 2009
SPRINGFIELD, Mass., , March 12, 2009 – The Springfield College Child Development Center has received five-year accreditation under the newly increased standards of the National Association for the Education of Young Children (NAEYC).
Responding to the announcement, Maureen Burke, director of the center, said, "For parents choosing a daytime program for their preschool-aged children, NAEYC accreditation is the national standard for judging quality. It attests to the excellence of the child development program, health and safety of the environment, and professionalism of the staff. We're proud to have earned this recognition."
Open to the community, the Springfield College Child Development Center fosters physical, social, emotional and intellectual development of children aged 15 months to five years. The teachers have a minimum of a bachelor's degree and are assisted by Springfield College students of early childhood education or a related field.
The center is located at 715 Wilbraham Road in a natural setting at the edge of Springfield College's 52-acre East Campus. Its program encourages learning through activities that pique children's natural curiosity and develop their competency, perception and self esteem.
NAEYC, founded in 1926, is the world's largest organization working on behalf of young children with particular focus on the quality of educational and developmental services for children from birth through age 8. It has almost 100,000 members, a national network of more than 300 local, state, and regional affiliates, and a growing global alliance of like-minded organizations. Enrollment information and tours of the center are available by calling 788-2451.
Recent Headlines
Springfield College 263 Alden Street, Springfield, MA 01109-3797 413.748.3000 | Employment at SC
Copyright © 2008-2009 Springfield College. All rights reserved worldwide.
Site design and production: Office of Marketing and Communications.
Copyright © 2008-2009 Springfield College. All rights reserved worldwide.
Site design and production: Office of Marketing and Communications.


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Peace Polo
Style: K1381N2B-WC2B
Short sleeve polo with cotton collar, tonal contrast trapunto stitch detail, vertical pick stitching and embroidered peace sign on the chest. Looks great paired with denim or sport pants.
- Cotton
Product Actions
Additional Information
Relaxed Fit
- Machine Wash
- Imported
This item can be returned, unworn and unused, within 14 days of delivery.


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Consultant: Concerns but no 'deal breakers" in sale of toll road to SANDAG
You wouldn't think of buying a house without thoroughly checking it out first – the foundation, the plumbing, the roof, the deed. Any hidden costs that would skew the deal.
So, imagine if you were about to put up $344.5 million for 10 miles of highway.
That's what SANDAG is about to do and on Friday its board of directors will receive the "due diligence review" on the South Bay Expressway, which this year emerged from bankruptcy.
The consulting firm HTNB has cast a discerning eye on the privately operated toll road, also known as State Route 125, looking at the road and buildings, toll and traffic management systems, operations and maintenance and financial audits.
In short, as with a well-lived- in house, they found things the agency needs to be concerned about – but no deal breakers.
Among the concerns listed in the HNTB report:
• A commitment to connect the southern end of SBX to I-905 (and thus the Mexican border) could cost SANDAG $30-35 million.
• Other interchange connectors – dependent on traffic growth – could cost $11 million.
• Special seal coatings on four of six bridges inspected could cost up to $100,000. (There are 16 more bridges to be evaluated).
• Recommended long-term bridge and pavement maintenance costs could run over $2.7 million and $2.1 million respectively.
• Pavement "distress and deterioration" on the northern portion of the road near Sweetwater Bridge need repair at a cost of up to $80,000.
• Sections of the Otay River Bridge could require remedial work – at $2 million – because an unapproved concrete mix was used during construction.
• Future widening of the toll road would be the responsibility of SANDAG, but also appears to be optional. No dollar amount is given in the executive summary.
• Some concern is raised over the software for the tolling collection system. The concerns "do not appear significant" but could limit SANDAG's ability to modify the system in the future. (The consultant praised SBX for improvements made to the system since launching in 2007.)
SANDAG plans to take over ownership of the franchise by Dec. 21.
On Friday, SANDAG staff will ask the board to approve an expenditure of $160,000 from contingency reserve funds for the next phase in the acquisition of the toll road franchise.
"The findings from the five due-diligence reports as well as the discussions with SBX representatives support SANDAG moving forward with the purchase of the SBX assets," writes executive director Gary Gallegos, in a report to the board.
He further notes that "Caltrans confirmed that the toll road has been maintained in conformance with its standards and no issues were cited during Caltrans' last inspection."
If the board accepts this report and allocates the funds, SANDAG's board will begin receiving massive amounts of documentation on the purchase in two steps, at its December 2 and 16 meetings. The board will be asked to select a final financing option, approve the purchase documents and authorize Gallegos to execute the final purchase of the franchise.


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With Instructables you can share what you make with the world and tap into an ever-growing community of creative experts.
share what you made with text, photos, video, and files
Create »
gather your favorite instructables together
This instructable teaches you how to fold T-shirts, in seconds.
Fold your T-shirt like that: Watch a video:
Lay down the T-shirt. Then pinch 2 places I marked. Be ready to flip one side.
Just flip one side onto another and take side of a t-shirt.
Raise your hands. Let the T-shirt hang in the air. Then be ready to fold it down.
Fold per folding line. Put it down. Nice....
Folding T-shirts this way saves you a lot of time. Remember to spend your saved time wirting some good instructables. ;) If you practise a little bit...
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How to Make a Symmetrical Cutoff Shirt for Exercisingby tylermv
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Flamenco dancing is always sexy - even when it's done in the bar of a three-star holiday resort in Costa Brava by a group of locals - but when you see the best that flamenco has to offer, it's jaw-droppingly hot. Mix it with top African dancing and you have a seriously steamy performance.
Paco Peña's Flamenco Dance Company are performing Quimeras at London's Sadler's Wells until December 1st - there are still seats available and it's an extraordinary show that had a standing ovation from a whooping audience when I saw it on the first night. The show is called Quimeras, and it tells the story of a group of migrants who have come to Spain from Africa in search of work. The poise of flamenco mixed with the fluidity of African dance is spectacular and so sexy!
Something that always strikes me about flamenco, and that struck me about the African dancers was that they don't look like stick insects - they have curves and they flaunt them. The Spaniards flaunt them with their tight, precise moves, and the Africans do so with their frenetic, daring ones. Also the older Spanish dancers up there are definitely the best. Experience is what counts here. Paco Peña, who has been playing flamenco guitar for over four decades, is so relaxed - a true professional, just enjoying himself up there with his troupe. Fantastic. BOOK HERE
PS IT'S STIR-UP SUNDAY TOMORROW - having put together the best collection ever of Christmas cake and pudding recipes, I won't be making either. Can't stand the things! But I will be making this Cranberry Cake from Country Living - I made it last weekend and my family were totally wowed. A real winner. Might put more cranberries in it this time. See more cranberry recipes here. And find all of our Christmas recipes here - we'll be adding more and more right up until December 25th.
Editorial assistant on allaboutyou; Music lover, travel bee and food fanatic.Read more
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Associate editor of All About You, loves life (mostly) and one-pan recipes (always).Read more


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When I'm trying to join Ubuntu client machine to domain server I'm getting this error:
Error: DNS_ERROR_BAD_PACKET [code 0x0000251e]
A bad packet was received from a DNS server. Potentially the requested address
does not exist.
This issue occurs when
Here is a sample resolv.conf:
I had this problem and spent 5 days trawling through forums. In the end I found a little note about DNS being picky about the spelling.
I fixed this by ensuring I used the uppercase letters in the FQDN where necessary. Windows doesn't care about upper and lower case but Linux does so try that.
The command I used was sudo domainjoin-cli join --disable ssh {domain name} {domain admin account name}
Hope this helps someone.


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Sony ST25i Kumquat to be called Xperia U when it launches
The Indonesian equivalent of the US FCC has given us the retail name of the rumored Sony Ericsson ST25i Kumquat. It's listed under the name "Sony Ericsson Xperia U", though by the time the phone is officially unveiled, we're sure that will have changed to just "Sony Xperia U".
That's all the new info available on the handset, but we expect to see the Sony Xperia U at the MWC in about a month. The LT26i Xperia S is also listed among the applications for certification, but we already know this one.
Anyway, you can brush up on the specs that the Sony Xperia U is expected to have in our rumor mill.
Also, with models named Xperia S and Xperia U, we can't help but wonder if Sony is considering a new naming scheme. We guess we'll have to wait until we find out how the Nypon and Pepper will be called officially.
Thanks to everyone who sent this in!
Sony ST25i Kumquat to be called Xperia U when it launches - reader comments
- david sharma
beautifull mobile xperia u
- Reply
- 2012-08-22 08:20
- 2@nA
- Anonymous
Does this phone come in the tapioca series??
- Reply
- 2012-05-17 08:31
- KAtB
- AniAich
Great Sony...!!! Probably this is going to be my first Smartphone...!!! This Phone is great..!!! Features, UI, OS (Android 2.3.7... Upgradeable to Android 4), Screen, Price Is reasonable, Size Is handy, Camera (5MP), Processor, Internal memory is nor...
- Reply
- 2012-03-02 08:23
- utgH


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Tea Party: We are Here to Stay
By Dan Maduri
Host, The News Hour
Follow @DanMaduri
Host, The News Hour
Follow @DanMaduri
After losing a primary to Senate Minority Leader Mitch McConnell the Tea Party are steadfast in foundation to change the outcome of elections.
Click Play:
How does one stay relevant without changing?
Tags: Democrats, GOP, Minority Leader Mitch McConnell, Tea Party


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- Blog - http://chelseagreen.com/blogs -
Author Robert Kuttner to Obama: Stand and Deliver
Posted By dpacheco On April 29, 2010 @ 1:42 pm In Politics & Public Policy | No Comments
A Presidency in Peril author Robert Kuttner [1] is concerned that the Democratic party may lose a generation of voters. The reality of Obama's presidency is proving to be too centrist and too incrementalist to really invigorate the nation's economic future. By cozying up to Wall Street and appointing Wall Street friendly people to positions of power in his administration, Obama is threatening not only the future of his party but the hope of rapid economic recovery and long term prosperity for the middle class. Can he turn things around before it's too late? Kuttner thinks the answer is a qualified "maybe."
From Citizen Vox on Public Citizen [2]:
"This could have been a moment — it could still possibly be a moment — if the Obama that we've seen flashes of becomes the president who rises to the occasion for the next several years. But if he doesn't, a moment to recreate a more balanced form of market and society will be lost."
Read the whole article here. [2]
Related Articles:
Article printed from Blog: http://chelseagreen.com/blogs
URL to article: http://chelseagreen.com/blogs/author-robert-kuttner-to-obama-stand-and-deliver/
URLs in this post:
[1] Robert Kuttner: http://www.chelseagreen.com/authors/robert_kuttner/
[2] Public Citizen: http://citizenvox.org/2010/04/27/author-robert-kuttner-on-the-obama-presidency-will-he-deliver/
[3] Dance of the Deficit Hawks: http://www.chelseagreen.com/blogs/dance-of-the-deficit-hawks/
[4] Huge Protests Planned Across the US to Demand Financial Reform: http://www.chelseagreen.com/blogs/huge-protests-planned-across-the-us-to-demand-financial-reform/
[5] Robert Kuttner: Dems May Weaken Bank Reform to Get GOP Votes: http://www.chelseagreen.com/blogs/robert-kuttner-dems-may-weaken-bank-reform-to-get-gop-votes/
Click here to print.