text:
Thanks for redeeming.{{else}}
Success! Thanks for repurchasing.{{/if}} {{else}} {{#if Expired}}
Increase my visibility!{{else}} {{#if IsMultiPack}}
{{#if HasMultiPack}} You have {{MultiPackCount}} top spot(s) left. Now loading you into the search listings... {{else}} You have used all top spots. Now loading you into the search listings... {{/if}}{{else}}
We are loading you into the search listing pages...{{/if}} {{/if}} {{/if}} {{/if}}
{{Current}} just saw you!{{/if}} {{#if LastTopSpotPurchaseIsMulti }} {{#if HasAnyTopSpot}}
{{#if HasFreeTopSpot }} {{ UnclaimedTopSpotFree }} Free {{/if}} {{#if HasPaidTopSpot }} {{#if HasFreeTopSpot }} & {{/if}} {{ MultiPackCount }} {{/if}} Top Spot{{#if Plural}}s{{/if}} Left{{else}}
0 Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{else}} {{#if HasFreeTopSpot }}
{{ UnclaimedTopSpotFree }} Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{/if}} {{else}} {{#if HasResults}}
{{Current}} see you now!{{else}} {{/if}} {{/if}}
You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
40 year old woman | North Miami, FL, USA | Seeking men 35-45 within 50 miles
Unique Classy Lady
I am unique, intelligent, independent, and enjoy trying new activities. I am honest and very passionate about those close to me. My favorite hobby is cooking. I am looking for a partner where we can be there to support each other in every endeaver. My relationship with the heavenly father, God, is one that I maintain on a daily basis. I am looking for one that will take his time to get to know me as I get to know him. I am open minded and will accept you for who you are. I am looking forward to sharing the events of our day with that special man over a home-cooked meal. Lets get to know each and have fun at the same time.
Alumni connections , Book club , Camping , Coffee and conversation , Business networking , Cooking , Dining out , Fishing/Hunting , Gardening/Landscaping , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Playing cards , Playing sports , Political interests , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Video games , Volunteering , Watching sports , Wine tasting
Aerobics, Auto racing / Motorcross, Basketball, Billiards / Pool, Bowling, Dancing, Football, Golf, Inline skating, Martial arts, Other types of exercise, Running, Skiing, Walking / Hiking, Weights / Machines
I exercise 5 or more times per week.
I have Dogs
I like Birds, Cats, Exotic Pets, Fish, Gerbils / Guinea Pigs / Etc., Horses, Other, Reptiles
I have a dog.
Some other viewpoint
Dave and Busters, Barnicles, Mimi's Cafe, Kobe, and Leroy Selmons
Bentley University, Waltham, MA
I love to eat Ice Cream outside on a warm day. My favorite color is red. When it is raining, I enjoy watching a movie with popcorn or listening to the rain with the windows open with my special someone.
Motorcycle riding and racing is exhilarating and fun as is attending comedy shows, movies, concerts, basketball and football games.
You are What you Think, Bible, Hatch
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'0" (152cms)
|5'4" (162cms) to 6'5" (195cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned
|No preference
|No preference
|No Way
|No Way, Cigar aficionado
|Social Drinker
|Social Drinker
|Education / Teacher / Professor
|Technical / Science / Computers / Engineering
|I'll tell you later
|No preference
|Never Married
|Never Married, Widow / Widower
|Have kids:
|No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|Definitely, Someday
|Black / African descent
|Asian, Black / African descent, East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian
|Spiritual but not religious
|Christian / Other
I attend worship service weekly.
|I'll tell you later
|No preference


text:
Hi all,
I am using GlobalMapper to generate raster data (in png format) to build
scenery for the Glider simulator "Condor The Competition Soaring Simulator".
The tools used to do scenery development have there own issues, but
discussion of them don't belong here.
This involves using SRTM3 .HGT files for elevation data from
ftp://e0srp01u.ecs.nasa.gov/srtm/version2/ and raster data from
a variety of sources.
So far, I've used been successful combining Landsat false color
images from https://zulu.ssc.nasa.gov/mrsid/.
I can load the .SID files and the .HGT files into GlobalMapper.
The raster data and elevation data line up perfectly.
On the other hand, the Canadian government provides complete landsat data
as in GEOTIFF format including good old RGB (seperate images for each channel)
When I load the geotiff files with the .HGT files into GlobalMapper
they don't line up. I think the issue is that the geotiff files are
in UTM NAD83 projection (to be honest, I don't know what that means).
On the other hand, the raster data from https://zulu.ssc.nasa.gov/mrsid/
are UTM WGS84.
So, here is the question. How can I change the projection, or whatever I have
to do to get the HGT files and the GEOTIFF files to line up.
Thanks for your help!!!

subset: commoncrawl


text:
Meeting Mr Burkeman
I've been in too many meetings recently.
I'm sure you have, too.
I don't need to be a mind-reader to know this. If you've been in one meeting, you've probably been in too many.
Because most meetings in advertising only move the game backwards.
A few months ago, one of my favourite writers, Oliver Burkeman, wrote in the Guardian about The Law of Triviality – whereby if executives have to talk about two new projects in a meeting – say, an atomic reactor and a company bike shed – they will spend a lot more time on the second topic.
The first is complicated and frighteningly expensive, and you risk all sorts of things if you try to make a point.
So the atomic reactor is covered in a couple of minutes.
But the bike shed can be debated for two and a half hours, "then deferred for decision to the next meeting, pending the gathering of more information".
Ring any bells ?
Ding dong merrily on high, of course it does …
But there are other problems in meetings. As Mr Burkeman wrote in another column, there is this thing which the Greeks call "akrasia" – deciding on the best course of action, and then doing something else.
Most meetings are a crash course in akrasia.
Specifically, there's the meeting where the first half is spent exploring exciting new possibiities and the second half is spent making sure that none of those possibilities is followed up on.
Of course, meetings are supposed to about making decisions – but try telling that to a meeting of marketing minds.
The only place most marketing minds meet is in agreeing not to make a decision.
Partly because agencies don't always want to sell ideas (their remuneration is based on the number of meetings they have) and clients are cautious about buying anything because if it doesn't work, they're in trouble.
My Burkeman (again) recommends the 37% rule.
So for instance if you are looking to buy a flat, reject the first 37% then pick the first one after that which is better than them. Or if none that follow are any better, pick the best one from the first lot.
Which sounds pretty random, but is better than enjoying a range of good ideas and then infallibly picking the worst.
But I always feel at my absolute lowest shortly after a meeting has finished.
It's not like the sexual guilt described by William Shakespeare as "the expense of spirit in a waste of shame" – and which involves tidying away the handcuffs and wiping up the chocolate sauce – it's a feeling that one has irrevocably and irredeemably thrown away the last three hours of one's life and only made things worse.
(Although that can happen after sex as well.)
At which point, the only meagre joy lies in finding the right word to describe the asininity of the lead individuals involved.
Was he a "dick" or an "asshole" ?
There's an important distinction.
Was she a "bitch" or "moron" ?
Very important to know.
Precision matters in these instances, and brings its own rewards.
As Mr Oliver Burkeman (quoted for the last time ever by me, in 2012) put it: "We can presumably all agree that Simon Cowell is a bit of a tosser. But his success makes it hard to dismiss him as a f*ckwit, while it's not clear he's guilty of the malice that would condemn him as a sh*t".
Wise words, indeed.
And I'm sure very comforting to Mr Cowell.
Happy Christmas to all of you. There may have been a few knobwipes, fenceshitters and fartheads along the way. But through the Christmas fug, it seems like they're a small minority.
And 2013 is another year …..


text:
Total Items: 0 Current Total: $0.00
View Larger Image
Email this product to a friend
Helping to both preserve the binding of your books and elevate them from the surface of your tables and altars, this wonderful device is a must have for anybody who spends long hours reading or pours over their books of shadow and other occult writings while they work their ritual craft. Carved of wood and stained a gentle brown that doesn't diminish the natural beauty of the wood's grain, it has been decorated with the design of leaves and foliage, forming two panels that unfold to create an "X" design.
This unfolded design creates two stable legs and an open v for your book to rest within. This v-shape allows the book's binding to settle without the strain placed upon it when it is laid flat upon a table, even as it is lifted several inches above the table or desk's surface. When folded flat, this book holder measures approximately 10" long and 4 1/2" wide, making it easily store upon your book shelves Unfolded, it is approximately 8 1/2" wide, 4 1/2" deep, and 4 3/4" tall.
Copyright © 1995 - 2015 By The Sword All rights reserved
Contact Us: firstname.lastname@example.com


text:
Translational cancer research brings together scientists from a range of disciplines to tackle this most pervasive of diseases. As Jenny Blair finds, it's an approach that could pay dividends
When biologists look at cell signaling pathways, they see receptors, enzymes and transcription factors. When engineers look, they see a circuit diagram, says John Hazle of the University of Texas MD Anderson Cancer Center. He recalls the time an engineering graduate student took one look at a cell-cycle control diagram and said, "That looks like the circuit diagram I was working on last week." She suggested untangling the pathways using differential equations, helping to clarify possible tumor proliferation mechanisms.
Such cross-disciplinary conversations are central to translational cancer research, an approach that teams physicians with experts in basic research fields to move lab findings to the clinic as quickly as possible – and vice versa. But it is no longer enough to simply sit with the "other side" during lunch. Driven by the need to accelerate the pace of discovery, as well as the high cost of clinical advances, scientists who study cancer are increasingly expected to cross traditional academic boundaries and become polyglots in the languages of the laboratory, the clinic and the latest technology.
And it's not just biologists or people with a life-sciences bent who find themselves working in cancer research today. "We've always had dribblings of physics, engineering and mathematics students that kind of eke their way into biomedical science," says Hazle, who is the chair of imaging physics at MD Anderson. But with the frontiers of cancer now reaching the molecular level, these outsiders are being welcomed into the fold.
Translational research may be trendy, but it's not necessarily new. "It's the future of research, but it's also been its past," says Robert Schneider, an associate director of the NYU Cancer Institute and its director of translational cancer research. Conversations between doctors and lab scientists used to be the norm a few decades ago, recalls Schneider, who trained alongside medical students while working on his doctorate. But once advances in science split genetics from cell biology and then molecular biology from cell biology, the training followed suit, he says, until "you could go through an entire PhD and not be able to identify the liver".
Even at the National Cancer Institute of the National Institutes of Health (NIH) in Bethesda, Maryland, much clinical and basic research was still carried out in separate buildings when Mike Boyd left to set up the Mitchell Cancer Institute at the University of South Alabama a decade ago. "Even in a place like that, there is a large proportion of activity that goes on in isolated labs – world-class scientists working on their highly specialized research in their labs. They rarely ever encounter the other side," he says.
That's changing. The Mitchell Cancer Institute, for example, encourages transparency among researchers, clinicians and patients by having facilities with glass walls. MD Anderson provides salary support to scientists to free them from grant worries and allow more space for creative collaboration.
After transitioning from a basic-research career about a decade ago, Schneider, like many translational scientists, now meets regularly with oncology colleagues to plan clinical trials based on his and others' lab findings. He says the NYU School of Medicine and its Cancer Institute instills translational thinking during lectures and journal clubs by covering everything about a disease, from molecular biology to treatment. The NIH, for its part, began funding translational research in the form of its Clinical and Translational Science Awards in 2006, with some 60 institutions now involved.
Starting early
Several universities offer dedicated courses that orient basic scientists to the bedside and clinicians to the bench. For example, the University of California, San Francisco (UCSF), offers health-sciences students summer and longer-term clinical and translational research fellowships. Along with other schools like Brown, Penn and NYU, UCSF also offers a master's degree in translational research. The Dana-Farber Cancer Institute in Boston hires a researcher every few years for hands-on translational training. And, in the wake of the staggering datasets generated by array and next-generation sequencing techniques, short workshops are popping up everywhere that cover must-know topics such as statistical genetics, gene mapping and bioinformatics.
For those with a background in physical sciences, the "Med into Grad" summer immersion course, which Hazle co-directs, is designed to give students from MD Anderson's medical physics program and Rice University's bioengineering program an introduction to medicine and biology that will help them apply their skills to biomedical research.
All this intermingling is happening in part because of the increasingly finegrained understanding of cancer. In 10 years, we will refer to tumors by their specific mutations, rather than their tissue of origin, predicts Schneider. Treating each patient will therefore require conversations between DNA sequencing experts, molecular diagnosticians, bioinformatics specialists and pharmacologists, among others. "It's just too big for any single person," he says.
Looking for a job in science or technology? Take a look at the latest opportunities on Newscientistjobs.com.
If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.


text:
The Norris Medical Library offers hands-on workshops to meet the information needs of faculty, staff and students. Workshops offered each quarter are determined by the interests of our users.
Technology Lunch SeriesLearn about the latest technologies as you enjoy a pizza lunch.
These Technology Lunch Series workshops are also listed on the library's Facebook page.
Workshops by RequestThe library designs customized workshops to meet the subject and scheduling needs of Health Sciences Campus classes and groups. Content can be drawn from one or more of our workshops or cover other topics of interest to the group. Schedule a customized workshop via the online form or contact the Educational & Research Services Division at 323-442-1483, email@example.com.
HouseCalls (individualized instruction)Personalized consultations are available to Health Sciences Campus individuals through the library's House Call program. HouseCalls may take place in the library, requestor's HSC office, or virtually via web conferencing. Topics may include workshop topics or specific research needs such as database searching. Schedule a HouseCall via the online form or contact the Educational & Research Services Division at 323-442-1483, firstname.lastname@example.com.


text:
Playboy #1 Red Star Copy (HMH Publishing, 1953) CGC NM 9.4 Off-white to white pages....
2012 November 15-17 Vintage Comics & Comic Art Signature Auction- Dallas #7066
|Sold for:
|Sign-in or Join (free & quick)
|Make Offer:
|Offers to date:
$55,000 on June 27, 2015
$30,000 on June 16, 2015
$36,000 on December 21, 2014
$30,000 on November 3, 2014
$35,000 on August 27, 2014
$28,000 on August 24, 2014
|Claim Item:
|Sign-in or Join (free & quick)
|Auction Ended On:
|Nov 15, 2012
|Item Activity:
15 Internet/mail/phone bidders
3,064 page views
Heritage Auctions
3500 Maple Avenue
Dallas, TX 75219
|Printable auction results for all items in the 2012 November 15-17 Vintage Comics & Comic Art Signature Auction- Dallas.
Playboy #1 Red Star Copy (HMH Publishing, 1953) CGC NM 9.4 Off-white to white pages. As Playboy aficionados know, the "Red Star" copy of the first issue is much rarer than the regular newsstand copy and possibly even rarer than the "Page 3" copy. This seems to be corroborated by data from CGC; namely, that of the 93 copies of Playboy #1 certified to date, just eight were "Red Star" copies. And only one of those eight has earned this lofty of a grade! This is just the third "Red Star" copy (so named because of the star appearing to the left of the "P" in "Playboy") of the issue we've offered in any grade. It's also just the second Near Mint 9.4 we've offered in any variation, with the previous one (a newsstand edition) selling for $31,000 earlier this year. If you have owned a raw copy of this issue or even held one before, you know how easily smudgeable the white cover can be, and understand why it's so tough to find this in Near Mint. The Marilyn Monroe cover is just one part of the appeal of the issue that launched Hugh Hefner's pop culture phenomenon. CGC census 10/12 (for Red Star copies): 1 in 9.4, none higher.
View large image(s) of this item
Service and Handling Description: Comics - Slabbed (certified) (view shipping information)
Sales Tax information | Terms and Conditions
Guides and Pricing Information:
Previous Prices from Heritage Auctions
|Sign-in or Join (free & quick)
Price Guide
|Sign-in or Join (free & quick)
Population Guide
|Sign-in or Join (free & quick)
Find Auction Prices for Comparable Items:
Sign-in or Join (free & quick) to see the full image


text:
Learn to program in C++ with these exhaustive C++ tutorials, covering everything from defining variables, functions, and custom classes to working with the C++ Standard Template Library.
Explore solutions to common C++ programming challenges, and compare the results with other programming languages, in the Code Clinic series.
Learn the basics of programming with C++.
"I have yet to find a course that I didn't find useful, well organized, and informative. And it's always at my fingertips." —Leslie M.
more from our members »


text:
BMW 7-Series driven in Russia
The land of carjacking and caviar. Where better to drive the new 7? Er...
Posted: 23 Oct 2012
The 7 still convincingly smothers the city, and we head to Kronstadt on the A118 motorway, an incredible piece of civil engineering suspended over the Baltic. Kronstadt was once the most heavily fortified island in the world, a supreme bulwark against naval incursions, before the sailors eventually turned mutinous in 1921. Islanders, eh? Our pearlescent white 750i prowls around its streets in the way only big German saloons can, an utterly incongruous presence in a garrison that was once one of the key strategic bases of the awesome Russian Baltic Fleet.


text:
As part of this weekend's Elinor Bunin Munroe Film Center launch, Oliver Stone stopped by the Walter Reade Theater on Friday night for a chat with Scott Foundas following a screening of Alexander Revisited, a re-cut version of his 2004 historical epic starring Colin Farrell and Angelina Jolie. The project extends the film's running time to over three and a half hours and includes an intermission like the big screen studio spectacles of yesteryear. "There are still things I'd like to change," confessed Stone, despite the painstaking attention and detail he exerted on the film's final cut.
In many ways, Alexander is a film that Stone has been wanting to make his whole life. During his time as an NYU film student, when making feature films seemed like an impluasible feat, Stone recalled fantasizing about going back in time to Alexander's age with a camera and coming back to Greenwich Village with documentary footage. Stone was finally able to get his chance at the epic tale, but only after having established himself as a top director. Even then, getting the film made proved to be a challenge in itself. "We shot in 100 days on 3 continents through independent financing from several different coutnries," said the director. "The only reason we got it financed in the first place was because we came on the heels of movies like Gladiator and Troy."
Financing wasn't the only hurdle the filmmaker encountered. Stone was faced with the task of constructing a narrative structure that would do justice to Alexander's life. It proved to be a complicated task, as Alexander's life doesn't really fit comfortably into a traditional narrative. "The logical thing would have been to make into a TV series," he said. "But it wouldn't have the same impact on a small screen and I don't think we could've gotten away with shooting what we did on a TV budget."
On casting the film, Stone revealed that he first approached Heath Ledger for the lead role in 2003. The late Australian actor turned down the opportunity to star in the film, telling the director he wasn't keen on playing a character he considered to be an imperialist. The imperialist issue would stick with the film though its release, a reputation Stone considers to be unfortunate. "I couldn't think of a worse time to release the film than the same year that George Bush set out on his own invasion," confessed the director. Stone took a positive spin, however, when asked about the film's dismal reception among critics and audiences upon its initial release. "I've had failures before...Nixon, Heaven & Earth...those were big movies that didn't do well," he explained. "But Alexander is a good example of not giving up. How does that quote go? 'The defeats are also victories'? I think it was Alexander who said that," said Stone, interrupted by a moment of doubt. "Or maybe it was Al Pacino in Any Given Sunday, I forget..."
Pictured above: Oliver Stone at the Film Society of Lincoln Center on Friday. Photo courtesy Godlis.


text:
Women's and Gender Studies Program
Jay Irwin
Assistant Professor of Sociology
Sexualities, Lesbian, Gay, Bisexual, Transgender and Queer Health, Women's Health
Ph.D., University of Alabama at Birmingham, 2009
402.554.2976, email@example.com
My main area of interest involves the health status and health care of lesbian, gay, bisexual, transgender and queer (LGBTQ) individuals. I am also interested in issues of sexual and gender identity and the social construction of identity categories. My current research focuses on self-identified lesbians in the Southeastern United States and their mental health and LGBTQ populations in Nebraska. I teach a number of courses, including Introduction to Sociology, Research Methods, Social Statistics, Medical Sociology and Sociology of Sexualities. I am an associate director of the Midlands Sexual Health Research Collaborative (http://www.unmc.edu/publichealth/mshrc.htm) and a member of the Professional Transgender Resource Network (http://ptrnnebraska.wordpress.com/).


text:
Professional Education
Doctor of Philosophy, Ruprecht Karl Universitat Heidelberg (2010)
Diploma di Laurea, Università Degli Studi Di Palermo (2005)
Stanford Advisors
Liqun Luo, Postdoctoral Faculty Sponsor
Organization and Assembly of Olfactory Circuits in Drosophila Melanogaster.
Our understanding of the mechanisms that establish wiring specificity of complex neural circuits is far from complete. During Drosophila olfactory circuit assembly, axons of 50 olfactory receptor neuron (ORN) classes and dendrites of 50 projection neuron (PN) classes precisely target to 50 discrete glomeruli, forming parallel information-processing pathways. Here we show that Toll-6 and Toll-7, members of the Toll receptor family best known for functions in innate immunity and embryonic patterning, cell autonomously instruct the targeting of specific classes of PN dendrites and ORN axons, respectively. The canonical ligands and downstream partners of Toll receptors in embryonic patterning and innate immunity are not required for the function of Toll-6/Toll-7 in wiring specificity, nor are their cytoplasmic domains. Interestingly, both Toll-6 and Toll-7 participate in synaptic partner matching between ORN axons and PN dendrites. Our investigations reveal that olfactory circuit assembly involves dynamic and long-range interactions between PN dendrites and ORN axons.
View details for DOI 10.1016/j.neuron.2015.02.003
View details for PubMedID 25741726
Sumoylation is a post-translational modification regulating numerous biological processes. Small ubiquitin-like modifier (SUMO) proteases are required for the maturation and deconjugation of SUMO proteins, thereby either promoting or reverting sumoylation to modify protein function. Here, we show a novel role for a predicted SUMO protease, Verloren (Velo), during projection neuron (PN) target selection in the Drosophila olfactory system. PNs target their dendrites to specific glomeruli within the antennal lobe (AL) and their axons stereotypically into higher brain centers. We uncovered mutations in velo that disrupt PN targeting specificity. PN dendrites that normally target to a particular dorsolateral glomerulus instead mistarget to incorrect glomeruli within the AL or to brain regions outside the AL. velo mutant axons also display defects in arborization. These phenotypes are rescued by postmitotic expression of Velo in PNs but not by a catalytic domain mutant of Velo. Two other SUMO proteases, DmUlp1 and CG12717, can partially compensate for the function of Velo in PN dendrite targeting. Additionally, mutations in SUMO and lesswright (which encodes a SUMO conjugating enzyme) similarly disrupt PN targeting, confirming that sumoylation is required for neuronal target selection. Finally, genetic interaction studies suggest that Velo acts in SUMO deconjugation rather than in maturation. Our study provides the first in vivo evidence for a specific role of a SUMO protease during neuronal target selection that can be dissociated from its functions in neuronal proliferation and survival.
View details for DOI 10.1523/JNEUROSCI.6574-10.2012
View details for Web of Science ID 000305295600024
View details for PubMedID 22699913
Synapse assembly requires trans-synaptic signals between the pre- and postsynapse, but our understanding of the essential organizational molecules involved in this process remains incomplete. Teneurin proteins are conserved, epidermal growth factor (EGF)-repeat-containing transmembrane proteins with large extracellular domains. Here we show that two Drosophila Teneurins, Ten-m and Ten-a, are required for neuromuscular synapse organization and target selection. Ten-a is presynaptic whereas Ten-m is mostly postsynaptic; neuronal Ten-a and muscle Ten-m form a complex in vivo. Pre- or postsynaptic Teneurin perturbations cause severe synapse loss and impair many facets of organization trans-synaptically and cell autonomously. These include defects in active zone apposition, release sites, membrane and vesicle organization, and synaptic transmission. Moreover, the presynaptic microtubule and postsynaptic spectrin cytoskeletons are severely disrupted, suggesting a mechanism whereby Teneurins organize the cytoskeleton, which in turn affects other aspects of synapse development. Supporting this, Ten-m physically interacts with ?-Spectrin. Genetic analyses of teneurin and neuroligin reveal that they have differential roles that synergize to promote synapse assembly. Finally, at elevated endogenous levels, Ten-m regulates target selection between specific motor neurons and muscles. Our study identifies the Teneurins as a key bi-directional trans-synaptic signal involved in general synapse organization, and demonstrates that proteins such as these can also regulate target selection.
View details for DOI 10.1038/nature10923
View details for Web of Science ID 000303149900034
View details for PubMedID 22426000
EBV, the prototypic human ?(1)-herpesvirus, persists for life in infected individuals, despite the presence of vigorous antiviral immunity. CTLs play an important role in the protection against viral infections, which they detect through recognition of virus-encoded peptides presented in the context of HLA class I molecules at the cell surface. The viral peptides are generated in the cytosol and are transported into the endoplasmic reticulum (ER) by TAP. The EBV-encoded lytic-phase protein BNLF2a acts as a powerful inhibitor of TAP. Consequently, loading of antigenic peptides onto HLA class I molecules is hampered, and recognition of BNLF2a-expressing cells by cytotoxic T cells is avoided. In this study, we characterize BNLF2a as a tail-anchored (TA) protein and elucidate its mode of action. Its hydrophilic N-terminal domain is located in the cytosol, whereas its hydrophobic C-terminal domain is inserted into membranes posttranslationally. TAP has no role in membrane insertion of BNLF2a. Instead, Asna1 (also named TRC40), a cellular protein involved in posttranslational membrane insertion of TA proteins, is responsible for integration of BNLF2a into the ER membrane. Asna1 is thereby required for efficient BNLF2a-mediated HLA class I downregulation. To optimally accomplish immune evasion, BNLF2a is composed of two specialized domains: its C-terminal tail anchor ensures membrane integration and ER retention, whereas its cytosolic N terminus accomplishes inhibition of TAP function. These results illustrate how EBV exploits a cellular pathway for TA protein biogenesis to achieve immune evasion, and they highlight the exquisite adaptation of this virus to its host.
View details for DOI 10.4049/jimmunol.1002656
View details for Web of Science ID 000287923500035
View details for PubMedID 21296983
Tail-anchored (TA) proteins insert post-translationally into the membrane of the endoplasmic reticulum (ER) and span the membrane by their C-terminal transmembrane domain. We have reconstituted membrane insertion of TA proteins from recombinant Asna1/TA protein complexes and ER-derived membranes. Our data show that Asna1 can mediate membrane insertion of RAMP4 and Sec61beta without the participation of other cytosolic proteins by a mechanism that depends on the presence of ATP or ADP and a protease-sensitive receptor in the ER membrane. By contrast, membrane insertion of cytochrome b5 can proceed independently of Asna1 and nucleotides.
View details for DOI 10.1242/jcs.055970
View details for Web of Science ID 000276912300016
View details for PubMedID 20375064
Tail-anchored (TA) membrane proteins are involved in a variety of important cellular functions, including membrane fusion, protein translocation, and apoptosis. The ATPase Get3 (Asna1, TRC40) was identified recently as the endoplasmic reticulum targeting factor of TA proteins. Get3 consists of an ATPase and alpha-helical subdomain enriched in methionine and glycine residues. We present structural and biochemical analyses of Get3 alone as well as in complex with a TA protein, ribosome-associated membrane protein 4 (Ramp4). The ATPase domains form an extensive dimer interface that encloses 2 nucleotides in a head-to-head orientation and a zinc ion. Amide proton exchange mass spectrometry shows that the alpha-helical subdomain of Get3 displays considerable flexibility in solution and maps the TA protein-binding site to the alpha-helical subdomain. The non-hydrolyzable ATP analogue AMPPNP-Mg(2+)- and ADP-Mg(2+)-bound crystal structures representing the pre- and posthydrolysis states are both in a closed form. In the absence of a TA protein cargo, ATP hydrolysis does not seem to be possible. Comparison with the ADP.AlF(4)(-)-bound structure representing the transition state (Mateja A, et al. (2009) Nature 461:361-366) indicates how the presence of a TA protein is communicated to the ATP-binding site. In vitro membrane insertion studies show that recombinant Get3 inserts Ramp4 in a nucleotide- and receptor-dependent manner. Although ATP hydrolysis is not required for Ramp4 insertion per se, it seems to be required for efficient insertion. We postulate that ATP hydrolysis is needed to release Get3 from its receptor. Taken together, our results provide mechanistic insights into posttranslational targeting of TA membrane proteins by Get3.
View details for DOI 10.1073/pnas.0910223106
View details for Web of Science ID 000272795300024
View details for PubMedID 19948960
Tail-anchored (TA) proteins are characterised by a C-terminal transmembrane region that mediates post-translational insertion into the membrane of the endoplasmic reticulum (ER). We have investigated the requirements for membrane insertion of three TA proteins, RAMP4, Sec61beta and cytocrome b5. We show here that newly synthesised RAMP4 and Sec61beta can accumulate in a cytosolic, soluble complex with the ATPase Asna1 before insertion into ER-derived membranes. Membrane insertion of these TA proteins is stimulated by ATP, sensitive to redox conditions and blocked by alkylation of SH groups by N-ethylmaleimide (NEM). By contrast, membrane insertion of cytochrome b5 is not found to be mediated by Asna1, not stimulated by ATP and not affected by NEM or an oxidative environment. The Asna1-mediated pathway of membrane insertion of RAMP4 and Sec61beta may relate to functions of these proteins in the ER stress response.
View details for DOI 10.1242/jcs.020321
View details for Web of Science ID 000256069500008
View details for PubMedID 18477612
We previously identified a cold shock domain (CSD)-containing protein (PIPPin), expressed at high level in brain cells. PIPPin has the potential to undergo different posttranslational modifications and might be a good candidate to regulate the synthesis of specific proteins in response to extracellular stimuli. Here we report the effects of T(3) on PIPPin expression in developing rat brain. We found that a significant difference among euthyroid and hypothyroid newborn rats concerns sumoylation of nuclear PIPPin, which is abolished by hypothyroidism. Moreover, T(3) dependence of PIPPin sumoylation has been confirmed in cortical neurons purified from brain cortices and cultured in a chemically defined medium (Maat medium), with or without T(3). We also report that about one half of unmodified as well as all the sumoylated form of PIPPin could be extracted from nuclei with HCl, together with histones. Moreover, this HCl-soluble fraction remains in the nucleus even after treatment with 0.6 M KCl, thus suggesting strong interaction of PIPPin with nuclear structures and perhaps chromatin.
View details for DOI 10.1210/en.2006-0660
View details for Web of Science ID 000242935200029
View details for PubMedID 17053029


text:
Seldom-used Miami Heat forward James Jones gave kids a quick lesson on how not to box out Thursday night against the Bulls. Known as a three-point specialist, Jones doesn't often find himself in the lane battling for rebounds. That much is obvious. For some reason, he decided to mix it up a little in what could (should) end up being the NBA Eastern Conference Finals preview.
Charging in for a rebound, Jones gave Bulls forward Joakim Noah a forearm shiver, a non-traditional move when boxing out. Jones was given a flagrant-two and ejected. It was an extremely unnecessary play, but I'll give him the benefit of the doubt. It was against Joakim Noah.
NBA News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
|Best of Yardbarker
|NFL News
|MLB News
Today's Best Stuff
For Bloggers
Join the Yardbarker Network for more promotion, traffic, and money.
Company Info
What is Yardbarker?
Yardbarker is the largest network of sports blogs and pro athlete blogs on the web. This site is the hub of the Yardbarker Network, where our editors and algorithms curate the best sports content from our network and beyond.
|© 2015 Yardbarker, Inc. All rights reserved. Use of this website (including any and all parts and components) constitutes your acceptance of these Terms of Use and Privacy Policy. (What's New?)


text:
Meyerhoff by the Numbers
Since 1993, the program has graduated over 900 students. As of January 2015, the program has achieved the following results:
- Alumni from the program have earned 198 Ph.D.s, which includes 39 M.D./Ph.D.s, 1 DDS/Ph.D. and 1 D.V.M./Ph.D. Our graduates have also earned 239 Masters degrees, as well as 107 M.D. degrees. Meyerhoff graduates have received these degrees from such institutions as Harvard, Stanford, Duke, M.I.T., Berkeley, University of Michigan, Yale, Georgia Tech, Johns Hopkins, Carnegie Mellon, Rice, University of Pittsburgh, NYU, and the University of Maryland.
- Over 300 alumni are currently enrolled in graduate and professional degree programs.
- An additional 290 students are currently enrolled in the program for the 2014-2015 academic year, of whom 53% are African American, 22% Caucasian, 18% Asian, 6% Hispanic, 1% Native American.
- The program is having a dramatically positive impact on the number of minority students succeeding in STEM fields; students were 5.3 times more likely to have graduated from or be currently attending a STEM Ph.D. or M.D./Ph.D. program than those students who were invited to join the program but declined and attended another university.


text:
Volvo Group Representation EU
Belgian Members of the European Parliament (MEPs), Commission officials and Representatives of the Council of the European Union had been invited to the stands of Volvo Trucks and Renault Trucks to learn more about the Group's two European truck brands
Showing a keen interest in our products, the EU policy makers entered the vehicles, tried vehicle simulators and also had the opportunity to test drive the fully electric Renault Maxity on the Eco Test Track, put in place for testing the latest electric passenger and light-duty vehicles.
At the Volvo Trucks stand, participants learned more about the latest features in terms of safety and environment of e.g. the new FH range, the FM MethaneDiesel and the FE Hybrid. Time was also dedicated to discuss the latest developments of on-going legislative proposals in the EU institutions, such as the noise emissions and digital tachograph legislations, linked to the vehicles.
The Belgian State Secretary in charge of Energy, Environment and Mobility, Mr. Wathelet, was particularly interested to learn about the Volvo Trucks campaign - Safe and Sober - promoting the use of alcolocks for professional drivers. On the spot, it was decided to organise a seminar on the issue in Brussels during the course of 2013 to raise the awareness among Belgian decision-makers. Last year, following the Swedish example, Belgium had launched its "Go for zero" public campaign and the present State Secretary is determined to pursue efforts in improving Safety on Belgian roads.
The Renault Trucks stand welcomed the whole automotive unit of the DG Enterprise, led by Philippe Jean (Head of Unit). After having paid great attention to the exposed Euro VI engine and to the further developments occurring on the new Renault Trucks' range, they had the opportunity to experiment the Optifuel simulators on the stand. The invitees particularly appreciated to learn how to save fuel in real driving conditions.
Held from 11 to 20 January 2013, the Brussels Auto Show focuses, every other year, on commercial vehicles in the so called "Truck & Transport" part of the exhibition.
Sonia Toro
Research and Communication Officer
+32 2 4825872


text:
Happy birthday, Will Ferrell: His top 5 party scenes
Will Ferrell is a comedic legend. There's no denying it -- hey, MTV even went so far as to award him a Comedic Genius award at the 2013 MTV Movie Awards. You won't find anyone arguing that he didn't deserve it.
Ever since he got his start on "Saturday Night Live" in the mid-90s, constantly sending viewers into hysterical laughter, this actor/comedian has delivered hit after hit. Whether he's starring in a movie, making a small cameo on a TV show, or even just stopping by "SNL" for a quick sketch from time to time, Ferrell steals the show.
Tuesday (July 16) is Ferrell's 45th birthday, and we can't even imagine the kind of shenanigans this comedy king is getting himself into. If his roles in the past are any indication, Ferrell knows how to party.
In honor of the funnyman's milestone birthday, we've rounded up our 5 favorite party scenes in his movies. These scenes span the range from epic to awesome to just downright frightening ... but every single one of them is absolutely hilarious.
From "Old School" to "Elf," "The Other Guys" to "Anchorman: The Legend of Ron Burgundy," check out some of Ferrell's hard-partying roles and let's hope he's having a better celebration than some of the characters he's played in the past (Warning: some clips contain NSFW nudity and/or language... but come on, you knew that already. It's Will Ferrell!):
"Old School" streaking
Bring your green hat!
"The Other Guys" bar scene
This isn't just any old drinking. This is serious drinking, with Terry Hoitz (Mark Wahlberg).
"Blades of Glory" drunk wizard
Those poor children.
"Anchorman: The Legend of Ron Burgundy" party
He's been going to the same party for 12 years now, but it just doesn't get any better than this.
"Elf" mailroom dancing
Only Buddy can make the mailroom fun.
Happy birthday, Will!


text:
News Summary: Senate eyes cyberstalking software
(AP) - ON THE RADAR: A Senate Committee was expected to approve legislation to close a loophole that allows cyberstalking apps to operate secretly on a cellphone and transmit the user's location.
CYBER SNITCH: Telephone companies can't disclosing to businesses the locations of people making traditional phone calls. But there's no such prohibition for a mobile device that sends an email, links to a website or launches an app.
STOPPING STALKERS: Victim's advocacy groups said the bill is a common-sense step to curb stalking and domestic violence by weakening a tool that gives one person power over another.
(Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


text:
25¢ hot dogs — All you can eat (Dine-in only)
Located in the heart of Boston's Theatre District, Jacob Wirth offers a rich tradition of colorful music and entertainment that has been bringing people together for over a century. Depending on the night, patrons may be enjoying a challenging game of trivia or treated to some of Boston's best young talent belting out theatrical standards. On Fridays, everyone joins in with Jake's ever popular Sing Along nights! To learn more, check out our full schedule.


text:
Liked Macklemore's 'Saturday Night Live' performance? Watch the hilarious 'Thrift Shop' music videoAdd to Favorites | Saturday Night Live
Unless you've been living under a rock, you've probably heard "Thrift Shop" on the radio, in a bar or club, or for the first time on Kevin Hart's episode of "Saturday Night Live." The track has a music video as well, which tells a much funnier story than the song on its own.
If you haven't seen it yet, we highly suggest watching the video below. It might not be censored like the "SNL" version, but it's definitely worth your time. Poppin' tags!
Photo/Video credit: YouTube


text:
Michael Eric Dyson Part II by Mitch E. Perry
WMNF Drive-Time News Thursday
On Saturday night, the black elite gathered at the Grand Hyatt hotel in Tampa.They were there for the the Gamma Omicron chapter's Harlem Nights Returns-themed, Carter G. Woodson Lecture Series, which this year featured as their guest social critic, radio host and prolific author Michael Eric Dyson.Before he addressed the hundreds in attendance, WMNF spoke to him. In the 2nd part of our interview, we asked Dyson about President Bush's State of the Union address, where he failed to mention Hurricane Katrina one time.A year and a half after one of the country's worst natural disasters, New Orleans population is little more than half it was before August 29th, 2005. We asked Dyson what he thought about the Federal response (roll tape#1 o.q." and the black list about")That's Michael Eric Dyson. His latest book, Debating Race, has just been published in the last few days.comments powered by Disqus


text:
Photo by © 2009 Matthew Mead
YIELD: Makes 4 servings
1. Preheat oven to 400°F. Line a roasting pan with foil and drizzle with olive oil.
2. Place asparagus in pan and drizzle liberally with olive oil. Roll the spears back and forth until they are completely coated.
3. Sprinkle on minced garlic, salt, and pepper.
4. Roast for 8 to 10 minutes, until lightly browned and tender when pierced with a fork.
5. Remove from oven, squeeze fresh lemon juice over top, and garnish with thyme leaves if using.
Reprinted with permission from Matthew Mead's Monster Book of Halloween by Matthew Mead, (C) August 2009, Time Inc Home Entertainment


text:
Get ready for the cool weather by knitting up this ingenious scarf-mitten combo. This simple, chic accessory needs only a couple of balls of yarn and couldn't be easier.view details
58,544 crafters have joined CraftStylish.
Create your profile and join the fun!
Our contributing editors are accomplished crafters, passionate about discovering and sharing new ideas and practical techniques. view all.


text:
Stories to Watch in 2012: U.S., China, Food, Renewable Energy, Rio+20by -
What are the top environmental and development issues that will shape 2012? This morning, I presented the World Resources Institute's 9th annual "Stories to Watch" at the National Press Club. While we can't predict the future, here's a rundown of the key issues to keep an eye on:


text: We are a US Authorized Night Detective dealer. We carry a large collection of new Night Detective Hunting Gear, Night Detective Military / Tactical Range Finders. Rangefinders.com is the primary source to search for top makers of Night Detective merchandise online. As a primary retailer, we provide low deals and the majority of orders exceeding $29.95 are eligible for Free Shipping. We ship quickly and secure. You can be comfortable ordering from Rangefinders.com because almost all Night Detective products we carry are reinforced by a warranty and our total satisfaction guarantee. We want you to be knowledgeable about our products so that you make the most effective decision. Browse how to where we feature suggestions on selecting the ideal merchandise from Night Detective to fulfill your wishes. You should also visit our reviews and hear what other consumers are advising. The best place to provide your thoughts and seek help is our forum. We employ qualified specialists that respond to concerns, provide advice, and explain how our products are utilized. Reach us via chat, phone, or e-mail. As you know, you can feel easy about your buy we have all the necessary information our online shoppers need to make an educated decision. We also give unbelievable dependability during the ordering process. Our secure servers, our BBB certification, and our Yahoo Fraud Prevention Policy all assist to ensure your privacy. We were also granted the distinctive Internet Top 500 title. At Rangefinders.com, our shoppers will discover a great mix of the most complete selection of Night Detective Hunting Gear, Night Detective Military / Tactical Range Finders at reasonable costs with helpful customer service, and top of the line product experience.


text:
The January transfer window has probably closed by the time you read this – but if it hasn't, then hopefully none of these eight players force through unexpected transfers over the next few hours!
However, for the good of their careers, they probably should have done.
For different reasons, the eight players who feature on this list should have pushed to leave their respective clubs on Friday.
They now run the risk of enduring more frustration over the coming months and, in several cases, even missing out on the 2014 World Cup finals in Brazil this summer.
So, will this lot turn things around for themselves over the forthcoming months? Should anyone else be on this list?
Have your say in the comments' section below.


text:
The Bachelorette
Bachelorette Desiree Hartsock and her pack of nomadic hunks recently blessed Atlantic City with their presence, and Brad McKinzie scored himself the first 1-on-1 date. According to Reality Steve, these two went to an amusement park (oh, the hijinks!), trolled around New Jersey in a Rolls Royce, and "ate dinner" (read: drank wine). But did boyfriend win a rose? Not so much.
Brad was sent packing thanks to some unexpected baby bama drama (dude has an adorable son named Maddex) that cropped up during his date. Apparently, Brad's sexy exy, Brittnee Nelson, got into a fight with her boyfriend while Brad was filming, and she decided to move from Colorado to Texas. No big deal, except she dropped Brad's kid off with his mom, which caused poor Brad to spiral into a panic.
Apparently, Brad learned this news of his son's abandonment while in California and still chose to accompany Desiree to Atlantic City, but it's possible that he had a change of heart and decided to reunite with his kiddo after a less-than-stellar date with Des.
Either way, Brad is clearly putting his child first, so amen! And who knows? Maybe we'll see his six-pack again on The Bachelor — single dads make the gown-clad ladies' knees weak.
Source: Reality Steve


text:
Coffee Talk: Changing Roles
By Rebecca Teti
Weekends: Changing Roles -- the needs of the sandwich generation
(Join each day's Coffee Talk discussion: Mon: Parenting; Tues: Open Forum; Wed: NFP; Thu: Marriage; Fri: Education; Sat/Sun: Changing Roles)
Our weekend forum is for issues related to "the sandwich generation." Coping with menopause, caring for aging parents, relations with adult children, grandchildren, going back to work after years at home. Want to hash out a difficulty, get some advice or share a strategy?
This is the place! Come join the conversation!
I am writing today for prayers for my mother. She has a lot on her plate right now. She is snapping at us and making us pretty miserable. She snapped at my husband today at a luncheon that was held after a Memorial Mass for my husband's brother. A lot of this is caused by stress that she has caused herself. She has put herself into a situation that she can't handle anymore. Prayers please. That's all I"m asking for. I'm not asking for any advice. I have my own way of coping with all this. Thank You all!
To Upset, God grant you peace. Prayers for your mother. May God help your mother and you deal with this matter..
Thank You NIta. I appreciate that!
There are plenty of labels who deal with attractiveness not to mention rolex replica uk kind of functionality. To illustrate, typically the Daytona show, without the benefit of solely Europe Navy, continues entitled to to complete the task precisely as it seems to have the whole set of vital elements to always be a particular. Following that may possibly turn out to be IWC, a second Europe follow business enterprise. This unique label documents the foundation for the purpose of more professional looks after not to mention discusses reliability not to mention chanel outlet activity more than anything else and yet wouldn't undermine concerning things. Graceful much too, and yet especially well-built, such looks after are able to bear harsh management. Aided by the assortment from labels, a particular simply cannot discriminate comfortably. Should you desire a good Europe follow, therefore Victorinox and / or Wenger could be your selection and yet if it is a little bit more manageable, one can find a factor outshines every one of your requirements from a Europe Navy follow. When ever you desire a wristwatch to find on a mankind, invariably you should check out the someone you could be investing in for the purpose of for you to settle on typically the follow to find. All particular iwc replica sale is different not to mention all mankind have your partner's likes and dislikes, which means another will most likely not desire a follow that you want.
It's a tremendous post. I am truly grateful for this blog and I was in fact looking for something impressive like this should stay longer here, discount codesread all the post very nice posting you have
clash of clans hack tool free download clash of clans hack download free
its so clever about the author thanks for such a nice website i really appreciate your work its fascinating and meaning full truly enjoyed reading your post !!! comedy nights with kapil download latest episodes Watch comedy nights with kapil online Comedy nights with kapil this week episode online Who is next guest [name] in comedy nights with kapil [cnwk] Songs pk mp3 songs download Download Miss Tanakpur Haazir Ho mp3 songs free download Miss Tanakpur Haazir Ho box office collection Download Bezubaan Ishq mp3 songs online free Bezubaan Ishq box office collection Download Uvaa mp3 songs online free Uvaa box office collection Download Second Hand Husband mp3 songs online free Second Hand Husband box office collection Download I Love NY mp3 songs online free I Love NY box office collection Download Bajrangi Bhaijaan mp3 songs online free Bajrangi Bhaijaan box office collection Download Aisa Yeh Jahaan mp3 songs online free Aisa Yeh Jahaan box office collection Download Bangistan mp3 songs online free Bangistan box office collection Download Drishyam mp3 songs online free Drishyam box office collection Download Brothers mp3 songs online free Brothers box office collection Download Welcome Back mp3 songs online free Welcome Back box office collection Download Phantom mp3 songs online free Phantom box office collection Download Shaandaar mp3 songs online free Shaandaar box office collection Download Pyaar Ka Punchnama 2 mp3 songs online free Pyaar Ka Punchnama 2 box office collection Download Kyaa Kool Hain Hum 3 mp3 songs online free Kyaa Kool Hain Hum 3 box office collection Collection of arijit singh song free download Arijit singh hit songs download free Arijit singh mp3 songs download online Download arijit singh mp3 songs online for free Kannada movie mp3 songs download Dr rajkumar hot mp3 songs download Dr vishnuvardhan mp3 songs download Download kannada songs of dr rajkumar ================================================================================== Happy Canada Day 2015 messages Happy Canada Day 2015 quotes Happy Canada Day 2015 sms Happy Canada Day fireworks images Happy international kissing day [2015] quotes Happy international kissing day [2015] sms Happy international kissing day [2015] images Happy Eid mubarak 2015 sms Happy Eid mubarak 2015 greetings Happy Eid mubarak 2015 cards Happy Eid mubarak 2015 sms in hindi Happy Parents Day 2015 sms Happy Parents Day 2015 wishes Happy Parents Day 2015 sayings Happy Parents Day 2015 images Happy Parents Day 2015 sms in hindi Happy International Cat Day 2015 sms Happy International Cat Day 2015 quotes Happy National Dog Day 2015 sayings Happy National Dog Day 2015 quotes
Certamente notevole scrittura dell'articolo. Sicuramente ben-to-do, oggetto e effetti è una catena. Ho ricevuto l'applicazione un'opzione come risultato di queste corso. Come ho Eccezionalmente negoziare la sua / il suo metodo in considerazione i suggerimenti illuminanti efficaci. Attualmente andate qui guida srl semplificata Dio ti benedica abbondantemente progettato per le punte continentali.


text:
In the news
Posted: April 27, 2014 at 5:12 a.m.
Michelle Obama, who as first lady has led efforts to fight childhood obesity, told a group of children during a question-and-answer session that "splurging is the key to life" if people regularly eat right and stay active, adding, "How would you appreciate vegetables if you never had chocolate?"
This story is only available from our archives.
Front Section, Pages 1 on 04/27/2014
« Previous Story
Sure, says Obama, he would save Putin's life
U.S. President Barack Obama said Friday that he'd save Vladimir Putin's life given the chance, playing down reports of personal animosity with the Russian leader. Read »
Next Story »
Names and faces
There were bowling pins, bathrobes, white Russians, and even The Dude himself. Jeff Bridges and his band performed Friday at Lebowski Fest, which celebrates Joel and Ethan ... Read »


text:
Thunderstruck 2012 DVDRip XviD-VoMiT
Scene group VoMiT released DVDRip of Thunderstruck (2012), a Family movie, directed by John Whitesell, starring Kevin Durant, Taylor Gray, James Belushi. Enjoy!
Plot: Brian is a 16 year-old who can't play basketball, but he still wants to play like his hero, Kevin Durant . At an Oklahoma City Thunder game, Brian gets chosen to shoot a half court shot, misses badly, and hits the mascot in the process. Later on, he gets a chance to meet Durant and expresses his desire to play just like him. When Kevin gives Brian the ball, they (unknowingly) switch talents. Brian becomes a high school phenomenon and Durant is stuck in a supposed "slump". Brian's success comes to the attention of Durant's agent, who figures out what happened to his client. With the Thunder on the verge of missing the playoffs, Brian and the agent try to give Kevin his talent back.
Genre: Family
IMDB rating: 4.6 (430 Votes)
Directed by: John Whitesell
Starring: Kevin Durant, Taylor Gray, James Belushi
Release Name: Thunderstruck.2012.DVDRip.XviD-VoMiT
Size: 700 MB
Quality: XviD, 624×352 @ 898 kbps
Audio : English, MP3 VBR 135 kbps
Runtime: 94 mins
Links: IMDB, Trailer, NewTorrents , Tinysubs
NFO: Here
Download: UPLOADED ( Single Link )


text:
If you are reading this in a room of six other people, one of you thinks the world is about to end. At least that's what a Reuters poll suggests. Ipsos Global Public Affairs conducted a poll for the news outlet and found that one in seven people believe the end of the world is just around the corner.
"Whether they think it will come to an end through the hands of God, or a natural disaster or a political event, whatever the reason, one in seven thinks the end of the world is coming," said Keren Gottfried, research manager at Ipsos Global Public Affairs.
U.S. and Turkey citizens rank among the most melancholy (or optimistic depending on how you look at it). In each country, 22 percent of citizens think the world will end in their lifetime.
According to the poll, people with lower incomes and people under 35 are more likely to think the world's demise will happen while they are alive.
Researchers think that a Mayan prophecy which predicts the world will end in 2012 may be behind the trend.


text:
Chico Flores - 7.48
The first of two Spanish sensations who arrived at the Liberty Stadium under the new management of Michael Laudrup. Chico was plucked from Serie 'A' side Genoa, having spent the 2011/12 campaign on loan with La Liga side Mallorca.
His recent absence from the Swansea first-team has been notable, with the side from south Wales losing five of the 11 games he has not featured, compared to just six of the 21 he has.


text:
Modified Mustangs & FordsProject Vehicles
Modified Mustangs & Fords Project Snake Charmer Web Diary
Project Snake Charmer is finished and on the road Check out the diary for more!
Each week we'll update our Web visitors on our progress right here with photos, video, and diary entries. Check back weekly as we share our progress, tips, anecdotes, and more while we assemble our Factory Five Racing roadster right before your eyes. And don't forget to get the full story in an upcoming issue of Mustang & Fords.
April 1, 2007
Total Build Time: 404 hours
Well, this is it. I bled the brakes again with my power bleeder, set the fan temp controller, and made another two laps around the block. I think the engine needs to be "burped" some more, as the engine temps have fluctuated a bit while driving, but then again it could be the location of the sending unit because the engine hasn't overheated or puked into the overflow once. I'll worry about that more once the Roadster comes back from the paint and body work phase, as I think it is merely a concern of getting the last bit of air out of the system (as it was with my soft brake pedal).
Over the course of this long day (nine hours) I removed the body, finished the installation of the driver's foot box aluminum, test fit and drilled the four wheel well splash shields (but did not rivet them, I'll leave that for the boys at KR Performance & Restorations to do on final body fit), and made cardboard templates of the trunk aluminum so that I can cut direct-fit carpet sections to carpet the trunk with when the Roadster returns. It wasn't until almost dark that I reinstalled the body, dry fit the wiper transmissions to the cowl, and hand formed the wiper cable tubing to the shape of the cowl.
After dinner I went back out to the garage and bolted the body down to the frame, hung the doors and trunk lid, and marked all bolt locations with tape so when KR Performance removes the body for the first time they don't miss a mounting bolt. Reliable Carriers has been called and I'm just waiting for the call back to tell me when the truck is coming, and then it's off to DVS Restorations first (www.dvsrestorations.com) for a once over on all fasteners, check and correct any bump steer, and so forth before it heads to KR Performance & Restorations (www.krperformanceandrestorations.com) from there to begin the paint and body process. Don't worry; our diary won't be stopping just because the car isn't in my garage. I'll be getting weekly updates from DVS and KR Performance and I'll be adding them to our site as I get them.
April 15, 2007
Total Build Time: 409 hours
Well, this is it. Reliable Carriers is on their way to pick our project up to transport it for paint. I've been going over the car for the last couple of hours, making sure I don't forget anything that has to be sent with the car. Would you believe I accidentally threw away the side louvers? I'm going to have to buy new ones now, but otherwise I think I have everything ready to go. I'm sending the door latches, hood latches, and a pair of tail lights (so they can match the body to the light housing), the assembly manual with annotations, the body splash shields, and more. I even went around the body and used painters tape and a Sharpie to call attention to any areas where there is a fastener retaining the body so the guys at DVS Restorations or KR Performance & Restorations wouldn't miss a fastener when removing the body and possibly damage something.
Around 3:30 pm the Reliable Carriers semi inched into our neighborhood. This bad boy is 83-feet long with a 12-foot sleeper on it and it was a tight squeeze through some of the corners, but they got in. After moving a few cars around that they already had loaded the day before they had the Roadster on the top tier and strapped down, ready to leave by about 4:30. It was exciting to see the project head off to paint, but at the same time it was sad to see the big empty spot in my garage too. I've got a couple of months before the car comes back to finish it, so I'll have to find something else to tinker with in the mean time. One idea is to rebuild a small-block with my son for a future car we plan to build together. Like I said in my last entry though, the guys at DVS Restorations and the guys at KR Performance & Restorations will be forwarding notes and photos for weekly updates, so don't go away.


text:
Regus Continues New York Expansion at 104 West 40th Street
Office space provider Regus has signed a long-term, 30,000-square-foot lease on the fourth and fifth floors at 104 West 40th Street, continuing the company's aggressive expansion in New York.
"We're really looking to expand on the west side of Manhattan, filling in the dots of where we aren't," Grant Greenberg, spokesman, told The Commercial Observer, adding that an exact opening date has not been nailed down but late 2013 or early 2014 is likely. Read More


text:
Statement of Significance (as of designation - May 23, 1968):
From 1885 to 1902, this was the home of Sinclair Lewis (1885-1951) the first American author to be awarded the Nobel Prize for literature (1930). His novel MAIN STREET (1920) was partly based on his impressions of Sauk Centre.
There are no threats to the landmark.
Landscaping has been undertaken at the property.
Comments and questions about the database may be directed to firstname.lastname@example.com


text:
Event Details
Date(s) & Time(s)::
August 23, 2014 at 11:00 AM until 11:55 PM
Location: Arts United Center/Main Street, 303 E. Main St.
Phone: Tena Woenker, 260-420-3266, ext. 3010
Email: firstname.lastname@example.com
Link: http://www.TasteoftheArtsFortWayne.org
Event Description
The 6th annual Taste of the Arts will expand with new evening activities on the Arts United Campus in downtown Fort Wayne. Taste of the Arts has quickly become one of Fort Wayne's most popular festivals with its unique blend of music, dance, theatre, film and artists demonstrating a vast variety of styles and talent from Fort Wayne along with dozens of local restaurants serving a wide assortment of food choices.
The festival is free and always held the weekend prior to the Labor Day holiday. Attracting over 25,000 people, Taste of the Arts has become one of downtown's largest single-day events. The event is free but proceeds from food and beverage sales raise funds for Arts United's mission to develop, coordinate and support arts and cultural efforts in Northeast Indiana.
Event Admission is FREE
No admission ticket for the event is necessary, admission to all areas of the event are free.
Food and beverage tickets are $1 each
Food and beverage tickets are required and will be sold at the event for $1 each. Multiple tickets may be required for a single item based on the value of the item. Tickets will be redeemed at each food vendor's booth.
Highlights of the 2014 Taste of the Arts:
Busker Square, Celebrating the Art of Street Performance!
Dancers, magicians, and music, OH MY! Busker Square returns to Taste of the Arts 2014 on Freimann Square from 11:00 a.m. – 7:00 p.m. to provide an exciting celebration of the arts through street performance! Be on the lookout for great local artists like The Harp Condition, Robot Girl, Hindered Folk, and the We D'fye Dance Troupe performing throughout the day as Busker Square allows you to enjoy the fun, uproarious, and unpredictable nature of buskers as they roam the area displaying their talents.
In addition to all of the fabulous performances there will be interactive activities happening as well! Fortune telling, face painting, and balloon artistry will be featured as well as special guests from the Appleseed Comic Con. Zach Kruse & Matt Gross will be at the Downtown Improvement District's information booth taking your input and making your ideas come to life in the creation of a Downtown comic strip!
Special Events
THE SANDLOT - An Outdoor Screening of the Original Movie
At 10:00 PM, the festival winds down with a free outdoor movie on the Arts United Center Plaza presented by Cinema Center. Read more about this outdoor movie event here.
BAE Systems Theatre
(inside the Arts United Center)
11:00 dAnce.Kontempoary
12:00 University of St. Francis
1:00 Fort Wayne Civic Theatre
2:00 Fort Wayne Dance Collective
3:00 SheeKriStyle Academy of Dance Arts
4:00 Fort Wayne Ballet
5:00 Mikautadze Dance Theatre
6:00 Kinetic Revelation
Sweetwater Plaza
(outside the Arts United Center)
11:30 Unity Performing Arts Foundation
12:30 Fort Wayne Scottish Pipes and Drums
1:30 Fort Wayne Taiko
2:30 Dances of Universal Peace
3:30 Fort Wayne Children's Choir
4:30 Exterminate All Rational Thought
5:30 Fort Wayne Ballet Youth Company
6:30 Old Crown Brass Band
7:30 Dance Tonight
Evening Schedule
9:00 Pyroscope Entertainment
FW Museum of Art Auditorium
11:00 Vocal Power Academy
12:00 Amaneceres de Mexico
1:00 IPFW Voice Department Faculty and Students
2:00 IPFW Music Department Faculty
3:00 Raq the Rivers Belly Dance Alliance
4:00 Hindered Folk
5:00 The Twilighters
6:00 Smooth Edge 2
FW Museum of Art Atrium
11:30 The Victim, The Witness
12:30 Amy Cox
1:30 Fort Wayne Philharmonic String Quartet
2:30 Dani House
3:30 Cathy Serrano
4:30 Ken Preston and Linda Kummernuss
5:30 Secret Mezzanine
6:30 Small Voice
Carson's Foyer
(inside the Auer Center Atrium)
11:00 Fred Rothert
12:00 Ted Yoder
1:00 Ricky Kemery
2:00 String Theory
3:00 Fort Wayne Philharmonic
4:00 Northeast Indiana Poets
5:00 Distractions
6:00 Gregg Bender Trio
7:00 Caleb Herber
Arts Lab Stage
(inside the Black Box Theatre - Auer Center)
11:30 Hearthstone Ensemble
12:30 Casket Sharp
1:30 Fort Wayne Youtheatre
2:30 Tracing Oceans
3:30 Pinky Swear
4:30 Gregg Bender Trio
5:30 Avocado Shag
6:30 Miss Fort Wayne and Friends
7:30 All 4 One Productions
Sweetwater Academy of the Arts on the Dessert Stage
(schedule coming soon)
YLNI Stage
(outdoor at the Barr Street Market)
9:00 AM - 1:00 PM 2 Before Noon
2:00 PM - 5:00 PM Juliana Neilson
DID Busker Square Stage
(in Friemann Square Park)
ongoing The Harp Condition
Electronic Music Stage
(in Auer Center parking lot)
(schedule coming soon)
Dessert Stage
6:00 PM Ken Jehle & Fernando Tarango - each masters in their own field, Ken's classical guitar meets Fernando's savvy pop vocal for an amazingly diverse & entertaining sound.
7:00 PM Shelly Dixon & Jeff McRae - acoustic rock duo divine! Shelly Dixon & Jeff McRae are veterans of the Fort Wayne music scene. Each has served time in successful rock and country/rock bands over the past decade, but they were recently liberated to pursue the purer and more demanding - yet more satisfying - acoustic sound.
8:00 PM The Wickersham Brothers - Fronted by Fernando Tarango, the Wickersham Bros. boasts an eclectic combination of Americana Roots, JazzRock and Funk that is always as danceable as it is entertaining.
9:00 PM Breaking Tradition - A young, up and coming, brother /sister, country band from north east Indiana, inspired by country and southern rock music. The band has a strong emphasis on vocals with two and three part harmonies. They rock everything from classic tunes to the latest hits with a few surprises in between.
2014 Participating Restaurants
Many restaurants will have beverages available too
•B Antonio's Pizza
•Baker Street Steakhouse
•Banh Mi Barista
•Club Soda
•Crackerjack Catering
•CS3 - Calhoun Street Soups, Salads, & Spirits
•Friendly Fox
•Granite City Food & Brewery
•Green Bean Delivery
•JK O'Donnell's Irish Ale House
•Kona Ice
•Mad Anthony Brewing Company
•Main Street Bistro
•Naked Tchopstix
•O'Reilly's Irish Bar & Restaurant
•Palmetto Poppers
•Purple Mountain Cheesecake
•Qdoba Mexican Grill
•Shigs in Pit
•Subway on Coliseum
•Sweets So Geek
•The Venice
•Vanilla Bean
•Waiter on the Way
Make Some Art Your Very Own
Be sure to stroll through the Fort Artisan fine art fair on Main Street and the Art Market Place on Barr Street while you are at the Taste of the Arts. Many area artists will be there to display and sell their artwork. Almost every kind of art you can imagine will be on hand. Artist selection for Fort Artisan will be determined by the Taste of the Arts' Fort Artisan Committee to ensure quality of the fine artwork and diversity in media. So be prepared to purchase and take some art home with you!
Taste of the Arts couldn't happen without many volunteers and sponsors including: Fort Wayne Metals, Emley Design Group, Frontier Communications, 97.3WMEE, BAE Systems, Carson's, Sweetwater, Downtown Improvement District, Indiana Michigan Power, Huisking Foundation, Shaffer Media, WANE TV, 89.1 WBOI and Projects with a Purpose.
For the complete line-up of acts, to sign-up as a volunteer or artist, or for more information about Taste of the Arts go online to www.TasteoftheArtsFortWayne.org.
What are your thoughts CLICK HERE to leave us a "QUESTION OF THE DAY" comment.
TextCaster alerts from 21Alive.com are your defining source for instant information delivered right to your cell phone and email. It's free, easy and instant. Sign-Up Now!
Powered by Summit City Chevrolet
© Copyright 2015, A Granite Broadcasting Station. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
- Musician's Friend Best Selection, Price & Service. Guaranteed.
Call our Gear Heads
at: 800-449-9128
Call our Gear Heads
at: 800-449-9128
Results 1 - 20 of 65 matches
Synthetic ivory. Martin-style pins. 2mm dots.
TUSQ XL offers vintage looks and permanent lubrication.
Teflon-impregnated self-lubricating head-nut to end string binding forever!
Helps produce a crystal clear bell-like high end, big open lows, and a noticeable increase in overall sustain.
Convert your electric guitar into a midi/virtual/acoustic controller with the Ghost LB63 locking bridge...
The ResoMax NV2 Bridge is designed to maximize harmonic content and richness in every note. It is made from a...
The TUSQ XL 1/4" Epiphone Slotted Nut (PQL-6060-00) is a replacement nut for Epiphone guitars.<br />
The TUSQ XL Jumbo Gibson Slotted Nut (PQL-6010-00) is a replacement nut for Gibson guitars.
The String Saver Barrel Saddles (PS-8108-00) are superior replacement saddles for Fender Mustang, Jaguar,...
Our product catalog varies by country due to manufacturer restrictions. If you change the Ship-To country, some or all of the items in your cart may not ship to the new destination.