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|MicrobiologyBytes: Virology: Poxviruses
|Updated: September 11, 2007
MicrobiologyBytes: Latest Updates
Introduction:Poxciruses have been known about for centuries - the characteristic "pocks" produced by variola virus (Smallpox) giving their name to all forms of infectious disease "a dose of the pox". Smallpox first appeared in China and the Far East at least 2000 years ago.
Smallpox has now been eradicated - the last naturally occurring outbreak of smallpox was in Somalia on 26th October 1977.
|Fowlpox virus
|Sheeppox virus
|Myxoma virus
|Molluscum contagiosum
|Vaccinia virus
|Orf virus
|Swinepox virus
|Yaba monkey tumor virus
|Entomopoxvirus A
|Melolontha melolontha entomopoxvirus
|Entomopoxvirus B
|Amsacta moorei entomopoxvirus
|Entomopoxvirus C
|Chironomus luridus entomopoxvirus
Variola (smallpox) virus is most closely related to camelpox (Gubser C, et al. (2004) Poxvirus genomes: a phylogenetic analysis. J.Gen.Virol. 85: 105-117). Both viruses are believed to have evolved from a comment ancestor, probably a rodent poxvirus, 5,000-10,000 years BC.
Thin sections in E.M. reveal that the outer surface is composed
of lipid and protein which surrounds the core, which is biconcave (dumbbell-shaped),
two "lateral bodies" (function unknown). The core is composed of a tightly
compressed nucleoprotein. To view an electron micrograph of a negatively-stained
particle click here.
Antigenically, poxviruses are very complex, inducing both specific and cross-reacting antibodies - hence ability to vaccinate against one disease with another virus (below). There are at least 10 enzymes present in the particle, mostly concerned with nucleic acid metabolism/genome replication.
Linear, d/s DNA of 130-300kbp. Ends of genome consist of a terminal hairpin loop (no free ends) with several tandem (i.e. direct) repeat sequences (this arrangement is found at the ends of chromosomes from a number of different organisms). The ends of the genome form direct repeats called inverted terminal repeats (ITRs). Several poxvirus genomes have been sequenced. Most of the essential genes are located in the central part of the genome, while non-essential (in tissue culture) genes are located at the ends. There are ~250 genes in the genome.
See the Poxvirus Bioinformatics Resource Center.
Vaccinia virus shows considerable resistance to the antiviral effects of interferons. One of the early genes of this virus, K3L, encodes a protein which is homologous to eIF-2α which inhibits the action of PKR. In addition, the E3L protein also binds dsRNA and inhibits PKR activation. As well as these, other poxvirus-encoded proteins interfere with the actions of complement, IL-1 and TNFs. Vaccinia infection of cells can confer protection from IFN on other viruses, e.g. Picornaviruses.
Members of the poxvirus family were the first DNA viruses shown to encode secreted versions of cellular cytokine receptors. Virus cytokine binding proteins are generally detected as either secreted glycoproteins or as transmembrane cell surface proteins. Virus cytokine receptor mimics (known as viroceptors) are soluble or membrane-bound proteins that may share significant homology to the ligand binding domains of cellular cytokine receptors and function by sequestering cytokine ligands from interacting to their cognate cellular receptors. Although many virus cytokine binding proteins were previously identified by their sequence relationship to cellular proteins, some virus-encoded soluble proteins have been identified which bind to and inhibit cytokines with high affinity but do not share any sequence identity to known cellular cytokine or immunomodulatory receptors.
|Open Reading Frame:
|Myxoma virus
|secreted CC-chemokine binding protein
|Myxoma virus
|secreted IFN-gamma receptor homologue and CC-,CXC-, C-chemokine binding protein
|Myxoma virus
|secreted TNF receptor homologue
|Vaccinia virus
|secreted IL-1b receptor homologue
|Vaccinia virus
|secreted IFNalpha/beta binding protein
|Tanapox virus
|secreted IL-2/IL-5/IFN-gamma binding protein
|At least 9 different poxviruses cause disease in humans, but variola virus (VV) and vaccinia are the best known. VV strains are divided into variola major (25-30% fatalities) and variola minor (same symptoms but less than 1% death rate). "Variolation" = the administration of material from known smallpox cases (hopefully variola minor!!!) to protect recipients - practiced for at least 1000 years (Chinese) but risky - Jenner was nearly killed by variolation in 1756!
The precise origins of vaccinia virus are uncertain:
Edward Jenner, 14th May 1796, used cowpox (Sarah Nemes!) to "vaccinate" 8 year old James Phipps, who he later challenged with VV (ethical?) and showed that he was protected. For more than 100 years, the "vaccine strains" (many origins) were propagated from arm-to-arm, but for at least the last 50 years, Vaccinia has been a distinct virus from cowpox - origin?
Vaccination was almost universally adopted worldwide around 1800, but it took
a major commitment from the WHO in 1965 to achieve eradication.
Eradication of smallpox was possible for 3 reasons:
UK Department of Health current vaccination guidelines
Infection with both viruses occurs naturally by the respiratory route and is systemic, producing a variety of symptoms, but most notably with VV characteristic pustules and scarring of the skin. Replication of vaccinia is more localized. Administration of vaccinia to immunocompromised hosts results in systemic infection with neurological damage or death. The vaccine is contraindicated in:
Aside for the development of new vaccines, future responses to poxvirus infection
are likely to include immune-based therapies such as humanized antibodies or
fragments of antibodies produced in animals, and antiviral drugs such as Cidofovir,
a DNA polymerase inhibitor developed for Cytomegalovirus retinitis, which
been found to be active in preventing Variola infection in cultured cells and
protects mice against lethal virus challenge.
From actually toxic to highly specific - novel drugs against poxviruses. Virol J. 2007 4: 8.
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Makes use of homologous recombination in infected cells to introduce foreign DNA coupled to VV promoter (e.g. tk) into virus genome. Numerous variants have now been made, some which include indicator systems such as beta-galactosidase to give recombinant plaques a blue colour (c.f. M13).
Problems for human vaccines:
The possible solution to this may be to use Avipoxvirus vectors, e.g. fowlpox or canarypox as 'suicide vectors' - undergo abortive replication in mammalian cells:
Pasteur Merieux Connaught's AIDS vaccine ALVAC-HIV (vCP205) consists of a recombinant canarypox vector expressing various HIV genes (gp120, gag and pro). Phase III clinical trials of this vaccine are currently planned to test it's efficacy.
Although smallpox has been eradicated, there are concerns about the potential use of variola virus as a weapon of terror. Consequently, destruction of the last (official) remaining smallpox stocks held in Russia and USA has now been postponed indefinitely. The possibility of an orthopoxvirus such as variola, monkeypox, camelpox or taterapox virus emerging or re-emerging as a threat to human health increases as the proportion of the world population that is immunologically naïve for orthopoxviruses increases. The parallel increase in immunosuppression due to AIDS increases the chance of OPVs jumping species and adapting to mankind (Rat-to-Human Transmission of Cowpox Infection). These possibilities justify and the retention of adequate stocks of vaccine (vaccinia) to combat poxvirus infections. Finally, it is unclear whether all, only a few, or just one of the differences between the genomes of viruses such as camelpox and smallpox are responsible for the inability of camelpox to cause human disease. Consequently, genetic modification of camelpox to delete genes that are present in camelpox but absent in smallpox might be highly dangerous. It might also be unwise to insert into camelpox genes encoding Th2 cytokines, which can cause a dramatic change in ectromelia virus virulence (Gubser C, Smith GL. The sequence of camelpox virus shows it is most closely related to variola virus, the cause of smallpox. J Gen Virol. 83: 855-872, 2002).
© MicrobiologyBytes 2007.


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American Giant manufactures clothing in the USA, focusing on what matters- fabric, fit, construction, durability. We're committed to offering exceptional quality at a fair price. If anything you've purchased from us isn't living up to this commitment, please send it back to us for a full refund any time, for any reason.

subset: commoncrawl


text:
Click on a thumbnail to go to Google Books.
Flight Behavior: A Novel (edition 2012)
by Barbara Kingsolver
Work details
Flight Behavior by Barbara Kingsolver
Top Five Books of 2014 (355)
» 7 more
No current Talk conversations about this book.
Clever thoughtful mixing boring and trapped marriage in USA falling apart with climate concerns. Good descriptions of toddler life
A nice blend of butterfly biology and good fiction.
Flight Behavior by Barbara Kingsolver; (2 1/2*)
The summary for Flight Behavior and the first part of the story made me look forward to an unusual and interesting read. I was disappointed when the unusual turned out to be the mundane life of Dellarobia Turnbow and her impoverished family. However the book did hold my interest only because of the information regarding the life cycle and migratory habits of the Monarch butterfly. Other than that the book became boring very quickly.
I have read more than one book on this subject matter that was much better written and far more interesting.
Kingsolver has a lot of interesting things to say about climate change, the denial of it, the failure of science communication, and how cultural connection can be more convincing than facts. So it's too bad she chose to say these things in another dull, preachy, flawed novel. Kingsolver has a knack for creating incredibly interesting, deep characters, and then doing nothing with them while she goes off on transparent tangents to plumb her own personal ideology.
It's been years since I've read any of Kingsolver's fiction, and this was an excellent reminder of why that is. I really wish she would stick to nonfiction writing, which is a much better use of her talents and clearly where her heart lies.
There is no doubt Kingsolver is a master of metaphor! As an author myself I am particularly aware of this, especially as it is my weakness. At one point I spotted three metaphors in two pages. Flight Behavior is beautifully written, but the detail is sometimes difficult to wade through. In choosing to focus on climate change it seems at times Kingsolver's tale of the poor butterflies completely overwhelms the participation of the humans involved. However, the development of Dellarobia's character, her coming of age as it were, is plausible under the circumstances; as we watch her attraction to Ovid, the scientist, take shape we have to sympathize with her desire to improve herself, to change her life, to become better than her sheltered background has led her to be. I felt the ending disappointing however. Poor Cub, Dellarobia's countrified husband, left high and dry, seemingly left to his own devices with little or no say in the matter. Everything came to what seemed an unexpected, unsatisfactory ending. Perhaps it stuck too close to what would have happened in real life!
Climate change, for every good and topical reason, headlines Barbara Kingsolver's marvelous eighth novel. But not to be undersold are its characters, rendered so believably and affectionately, they warm the atmosphere on their own.
...... Kingsolver's masterly evocation of an age – ours, here, now – stumbling wilfully blind towards the abyss is an elegy not just for the endangered monarch butterfly, but for the ambitious, flawed species that conjured the mass extinction of which its loss is a part. Urgent issues demand important art. Flight Behaviour rises – with conscience and majesty – to the occasion of its time.
References to this work on external resources.
Wikipedia in English
No descriptions found.
Set in the present day in the rural community of Feathertown, Tennessee, Flight Behavior tells the story of Dellarobia Turnbow, a petite, razor-sharp 29-year-old who nurtured worldly ambitions before becoming pregnant and marrying at seventeen. Now, after more than a decade of tending to small children on a failing farm, oppressed by poverty, isolation and her husband's antagonistic family, she has mitigated her boredom by surrendering to an obsessive flirtation with a handsome younger man. In the opening scene, Dellarobia is headed for a secluded mountain cabin to meet this man and initiate what she expects will be a self-destructive affair. But the tryst never happens. Instead, she walks into something on the mountainside she cannot explain or understand: a forested valley filled with silent red fire that appears to her a miracle. After years lived entirely in the confines of one small house, Dellarobia finds her path suddenly opening out, chapter by chapter, into blunt and confrontational engagement with her family, her church, her town, her continent, and finally the world at large.--publisher.… (more)
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Padres again beat Pirates at PNC
Defensively, both made late-inning plays worthy of instant replay.
Cedeno raced to his right in the seventh, fielded Garrett Jones' grounder on the grass of the 5.5-hole and threw out the pinch-hitter while spinning in mid-air.
Gyorko raced to his left with two out in the ninth, make a diving stop of Andrew Lambo's grounder and threw out the pinch-hitter while sitting in the ground.
"Jedd and Cedeno, those two guys up the middle have been impressive," said Stults, who turned the game over in the sixth to his bullpen.
Tim Stauffer followed with two scoreless innings. After Nick Vincent worked a perfect eighth, Luke Gregerson, in the closer's role because Huston Street is attending his grandmother's funeral, picked up his fourth save of the season.


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Charleston, SC (PRWEB) October 27, 2013
Author Pansy Clayton is a simple southern woman who has taken control of her type 2 diabetes and seeks to inspire others to do the same.
In her new book, "SOS: Simple Old Solution for Type 2 Diabetes", Clayton reveals the last 10 years of her life since being diagnosed. Readers will catch a glimpse into her successful diet of fruits, vegetables, and small amounts of meat. With the increasing amount of cases of diabetes in the US, Clayton hopes to lead individuals to a healthier lifestyle and prevent the organ and limb damage that many of type 2 diabetes patients suffer.
Along with diet and health advice, SOS: Simple Old Solution for Type 2 Diabetes provides personal success stories to educate readers about the disease and how to prevent the detrimental effects it can cause.


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AS African champions Zambia prepare to take on the 'Palancas Negras' of Angola in an international friendly this afternoon, coach Herve Renard has warned opponents at the 2013 Africa Cup of Nations finals that the Chipolopolo would be a difficult team to beat.
Renard, who is using the match to gauge the Chipolopolo's readiness ahead of the AFCON title defence that kicks off on January 19, told reporters in Johannesburg yesterday that it would be difficult for any team to beat Zambia at their 'second home' in South Africa.
The 44-year-old taskmaster, who is in his second spell of coaching Chipolopolo, says there is no pressure on his squad, from which three players must drop out by the midnight GMT deadline on January 9 for the final 23-man squad.
"There is no pressure on us because no-one outside Zambia expects us to win the competition again. People do not want to take risks with their predictions," Renard told Sapa-AFP.
"If we do not retain the title it simply means another team was better than us, but it will be very difficult to beat this team in South Africa, which is like a second home for us," he added.
Renard wants his team hyper sharp ahead of the opening pool game against Ethiopia, the 1962 champions who are back at the tournament after a 31-year absence.
"The first game against Ethiopia is very important - it is crucial to start the tournament well. Our aim is to finish first in the group," Renard said.
Nigeria, shock absentees from the 2012 Cup of Nations, and Burkina Faso are the other Group C contenders with the Super Eagles and Chipolopolo expected to fill the top two places and reach the quarterfinals.
Tradition suggests an uphill battle for Zambia to keep the trophy and pocket another $1.5 million cheque as only Egypt (1959, 2008, 2010), Ghana (1965) and Cameroun (2002) have successfully defended the title.
The match against Angola, which starts at 16:00 hours at Dobsonville Stadium in Johannesburg, South Africa, is one of the four hectic matches that the Chipolopolo will play before the 2013 Africa Cup of Nations kicks off on January 21.
After the Angola friendly match, Zambia plays Morocco on January 8 before the Chipolopolo return home with a 'goodbye' match against Norway, and then Namibia will come calling on January 15 at Mbombela Stadium in Nelspruit.
A practice match against Swaziland, which was set for today, is also on cards at a date and venue to be announced.
This will be the first international friendly match that Renard will be playing with an almost full squad comprising players that won the 2012 AFCON edition save for strikers Jacob Mulenga and Emmanuel Mayuka, who are expected to join the squad today and tomorrow, respectively.
Kennedy Mweene should start in goal ahead of Joshua Titima and Kalililo Kakonje.
Defenders are Emmanuel Mbola, Chisamba Lungu, and Hichani Himoonde while veteran Chintu Kampamba might start in place of Stoppila Sunzu, who is expected to leave for England to finalise his move with Reading.
Joseph Musonda, Davies Nkausu, Saulani Phiri and Francis Kasonde are the other options in defence.
With Rainford Kalaba likely to miss the match as he recovers from injury, Renard would obviously go for Nathan Sinkala and Isaac Chansa in the heart of the midfield while Felix Katongo and Jonas Sakuwaha might start.
In attack, Renard has the option of starting with Collins Mbesuma and captain Christopher Katongo with James Chamanga as another option.
Meanwhile, Football Association of Zambia (FAZ) spokesperson Erick Mwanza said that Mulenga, who plays for FC Utrecht, was scheduled to arrive today and should immediately join the team and start training for Zambia's first game at the tournament against Ethiopia on January 21, in Nelspruit.
The arrival of the two hit-men, who will miss today's match against Angola, would complete Renard's squad readying to retain the AFCON crown won for the first time last year in Libreville, Gabon, after an exciting final against 'The Elephants' of Ivory Coast.


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Mike V's Countdown To Opening Day:
Here are a couple pictures I took from my seats at Shea Stadium on Opening Day 2006. On April 3, 2006, the Mets took on the "NATS," with Tom Glavine on the mound. The Mets won the game.
Check out the ads on the outfield wall. I am pretty sure I didn't think anything of the AIG sign at the time.
I was living in North Carolina in 2006, but was so committed to making it to Opening Day, I was willing to buy a "six pack" to make sure I would get in. It wasn't too bad when you consider the face value of these incredible seats was $18 — less than a third of today's $63 face value.
To get fans pumped up in the winter of 2005/2006, the Mets had picked up Carlos Delgado and Billy Wagner (as well as Paul LoDuca to replace borderline-Hall-of-Fame candidate Mike Piazza).
A podcast about the Mets and Star Wars I'd Just As Soon Kiss A Mookiee
Bored with Sports Talk Radio? Try Alternative Sports Talk via TuneIn


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Countries to Play in U.S. to Prepare for World Cup
NEW YORK (AP) — Defending champion Spain will prepare for the World Cup in the United States along with Greece, Bosnia-Herzegovina, Ivory Coast, Nigeria and Honduras. Soccer United Marketing, an affiliate of Major League Soccer, says it will organize
Most World Cup Ticket Requests Not Filled
Less than 10 percent of ticket requests will be filled in FIFA's second phase of allocations for the World Cup. FIFA says it has received 3.5 million ticket requests in the second phase and that 80 percent of the
USA In Group G With Germany, Portugal, and Ghana
Group A: Brazil, Cameroon, Mexico, Croatia Group B: Spain, Chile, Australia, Netherlands Group C: Colombia, Ivory Coast, Japan, Greece Group D: Uruguay, Italy, Costa Rica, England Group E: Switzerland, Ecuador, Honduras, France Group F: Argentina, Nigeria, Iran, Bosnia-Herzegovina Group
USA Looks to Be Heading Towards A Group of Death
The allocation of pots for the FIFA World Cup Brazil 2014 Final Draw were determined today with the United States Men's National Team placed into Pot Three.
3 People Are Dead After Crane Collapses At World Cup Stadium
A crane collapsed on Wednesday at the construction site of a future World Cup soccer stadium in Sao Paulo, Brazil, killing at least three people and causing damage to the structure, local media said.
2014 FIFA World Cup Field Is Set
Two years and 159 days after the opening whistle of qualifying, the 2014 World Cup field is set.
Nearly 900,000 Tickets Sold for 2014 World Cup
FIFA says nearly 900,000 tickets have been allocated to fans from 188 countries in the random selection draw for the 2014 World Cup, the highest number ever in the first phase of sales.
Luis Suarez Looks to Help Uruguay
Luis Suarez believes a 'happy' return to the Liverpool squad will help him propel Uruguay into next year's World Cup.
Argentina & Urugauy Climb FIFA Rankings
The 185 matches played in the past month have certainly left their mark on the current edition of the FIFA/Coca-Cola World Ranking.


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Donald Gets Drafted is a Walt Disney cartoon starring Donald Duck. It was released on May 1, 1942 by RKO Radio Pictures.
The short opens up on the draft card of Donald Duck, dated March 24 1941 showing that his middle name is Fauntleroy. While walking to the draft board, Donald passes along several recruiting posters advertising "how great the army is". The posters show events that occur in the song, for example, in the song, the singer says "You used to have to walk a mile for beans, not they bring them to you" with a poster of a waiter bringing a "soldier" in a bathrobe a two coarse breakfast on a tray. Enticed especially for the Army Air Corps, featuring attractive women and the promise of escorting them around, Donald decides that he "wants to fly". Entering the Draft Board office number 13, Donald walks up to the recruiter, hands him his slip and says, "Hello General, I want to be a flier." Donald then proceeds to make aircraft engine noises with this mouth with outstretched wings. Donald eagerly wants to fly, wanting to skip the physical examination.
After knocking on the door, a hand grabs Donald by the neck and wrenches him inside the room. Doctors rapidly shove Donald around while asking questions. Finally, Donald is thrown on an examination table and a doctor takes his pulse, which is a xylophone melody. He is then shoved to another doctor who listens to Donald's heart with a stethoscope. The heart rhythm is a brief excerpt of "You're in the Army Now". A third doctor grabs Donald and checks his ear. Two lights shine out of Donald's nostrils and the Doctor proclaims "Hmmm...nothing here". A fourth doctor sticks a tongue depressor in Donald's mouth and tries, to no avail, to make Donald say "Ah". Donald simply chokes. After being diagnosed with flat feet, Donald is shown a red card by the doctor who asks the color. As the color is spelled on the card, Donald simply reads the card. The same occurs with green, with the doctor saying the color. The second time however, Donald says blue, but doctor says "close enough".
An alarm clock, with very loud ticking, is held up to Donald's ear. The doctor asks if Donald can hear it and Donald wearily nods. Donald is then striped naked from measurements. After being measured, an over-sized shirt is thrown of Donald with a small hat. The first had is swapped with a larger hat and a pail of water is slashed on Donald to make the wool shrink. The, Donald has the letters "O.K" stamped on his rear end, ending the physical. In many wartime cartoons, the protagonist has either "O.K" or "4F" stamped, signifying army material status.
Once Donald becomes inducted into the army, the shot opens up on airplanes, presumably C-47s with Donald gazing up at them, wishing he was in one of them while marching in formation. As Donald gets distracted, Sergeant Black Pete, the company Sergeant, orders Donald to get back in line as Donald was falling behind. After halting, Donald continues to march, unaware that the rest of the company, keeping up the rhythm of "Left, Left, Left Right Left". Black Pete yells halt once more, this time, Donald hears and stops. Embarrassed, Donald looks up at Black Pete and says, "Hiya, Sarge".
The sergeant makes Donald turn about face, to which Donald has trouble accomplishing. Placing his feet the wrong way and spinning too quickly, Donald rips Black Pete's tie with in two his bayonet. Black Pete does not become angry, only examining his tie and turns to face Donald face-to-face. Turning away from Donald, the sergeant dismisses the company, except for Donald, whom is promised "special training". When Pete asks for Donald to shift his rifle to his left shoulder, the bayonet rips of the brim of his campaign hat. Black Pete then asks Donald to present arms, which Donald fails to do twice: the first error being that he switches his hat for his rifle; the second error being Donald, trough some maneuver, gets the remainder of his hat atop the bayonet, which rips and falls down over Donald's face.
Black Pete lets out a shrill whine and then calms down, then commanding Donald to commence a forward march. Donald, through another miracle, plants the bayonet in the ground and becomes wedged between the shoulder strap. Then for the left command, Donald fits the rifle through his sleeves with only the butt of the rifle and bayonet exposed. Black Pete sighs in pain, saying to Donald, "You're hopeless". Black Pete then bats Donald away and, due to the rifle still being in Donald's shirt, causes Donald to be planed in the ground. Pete then spins Donald around, which dislodges Donald. Donald gets angry, picks himself up and shouts, "Phooey on you Sarge, I Quit!" Black Pete whirls around, taking off his shirt and hat, revealing a pair of Brass Knuckles and challenging Donald. Donald backs down and Black Pete, in the name of learning discipline, makes Donald stand perfectly still over an ant hill, not moving a muscle.
However, ants start to come out of the hill, causing Donald to scratch at them, which Black Pete interprets as intentional moving and calls Donald back to Attention. This occurs several times. As swarms move up on Donald, his tails picks them off, eventually becoming a windshield wiper. One ant manages to get on Donald's bill, and explores around. Despite Donald's best efforts to dislodge the ant, nothing works.
Finally Donald snapped. Running around to get off the ants, Donald starts firing his gun. Black Pete thinks that Donald is firing at him, but that is not the case. Running up a tree, not after getting shot several times in the rear, Black Pete pokes his head out of the bushes and blows his whistle to have Donald stop firing. However, each time Black Pete blows the whistle, a bullet whizzes by the same spot.
The scene fades out to Donald on KP duty, peeling and slicing potatoes, with "The Army's not the Army Anymore" playing in the background. Donald peels the skin off of one potato completely and holds it up, spelling out "Phooey". After discarding the peel, Donald returns to peeling, while the shot zooms out to show an entire room filled to the brim with potatoes.


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Scoreboard: 11th of 15 teams at the Mount Holyoke Invitational, South Hadley, Mass., 9/22-23
Schedule: Saturday-Sunday, Oct. 13-14, at Ann S. Batchelder Invitational, Wellesley, Mass.
- Holy Cross will be off until it returns to action when it takes part in the Ann S. Batchelder Invitational, on Saturday and Sunday, Oct. 13 and 14, at the Nehoiden Golf Club in Wellesley, Mass. The Crusaders last took part in the Batchelder Invitational in the fall of 2009, when they placed sixth out of seven schools.
- Two weeks ago, the Crusaders placed 11th out of 15 schools at the Mount Holyoke Invitational, held at the Orchards Golf Club in South Hadley, Mass. Holy Cross finished with a total of 714 strokes as a team over two rounds
- Senior Kelly Reagan (Mendota Heights, Minn.) was the team's top finisher at the Mount Holyoke Invitational, finishing in 30th place with a total of 172 strokes over two rounds. She shot an 83 during the second day of the event, good for the lowest 18-hole total during her time at Holy Cross. Over the course of her collegiate career, Reagan has averaged 95.6 strokes per round.
- Freshman Marisa Cameron (Garden City, N.Y.) tied for 36th place at the Mount Holyoke Invitational with 176 total strokes over two rounds. Through two events played this year, she now leads the team with an average of 87.5 strokes per round.


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IN THE Commons, it is traditional for the Whips Office to set rookie MPs to work on the committee stages of whatever it generally considers to be the most obscure orders currently passing through Parliament. So when I first became an MP in 1962 it was not long before I was working on the Feral Mink Bill. I now realise that I was put there to make up the numbers. However, little by little my interest in the problem of feral mink grew.
Mink can wreak havoc among native species. As Rob Edwards recently reported, descendants of animals that escaped from fur farms long ago are wiping out wildlife in parts of Britain (This Week, 29 November 1997, p 26). It stirred me to write to Lord Sewel, agriculture minister at the Scottish Office, about the effect of escaped mink on seabird population on the west coast of ...
To continue reading this article, subscribe to receive access to all of newscientist.com, including 20 years of archive content.


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Welcome to DrivingHorseBits.com
We hope you enjoy our site and find it to
be an informative tool useful in helping to
enhance and achieve maximum potential
for you and your horse. We feel that you
will find the Interchangeable Driving Bit
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the driving horse world as well as the
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We ask that you take time to read about
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browse our products. Please refer to 'The
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hope that you find our system to be as
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Thank you for visiting, come back often,
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cial advisors will leave the profession by the end of the year. A representative of the authority told me that the average advisor in the U.K.
is in his 50s and has been working in the industry for nearly 30 years
(sound familiar?); many advisors will choose not to reinvent their practices to focus on advice rather than products.
It's important to note that the U.K. is not the only country developing such regulations for financial services practitioners. Australia, for
example, rolled out a ban this year on "conflicted remuneration," saying that advisors providing financial product advice to clients can only
receive remuneration from their clients. (We'd call that fee only.) The
Netherlands, Hong Kong and India are all following suit.
Here's an exercise: Imagine how your current practice would
need to change in the face of new regulations similar to the U.K.'s:
demanding fee and service transparency, banning commissions on
investment products and raising the level of professionalism of
investment advisors.
You'd need to consider several aspects of your business.
Charging for advice: If you are not already charging for advice, you
would need to. That means separating your advice from execution
and being able to demonstrate your value to clients clearly. It also
means having a dedicated pricing structure that takes into account
the costs to deliver your services, while factoring in your expected
profit margin.
You'd then need to strategize on how you get your clients, how
they find value in what you do and whether they will happily pay for
your services. You would want to segment your current client base,
specifically identifying your relationships by complexity of advice and
profitability. You would likely need to develop a new service mix, creating levels of services and activities that you will perform for different
segments of your clients.
Because of the new fee arrangement, you will probably need to
prune your current client base for unprofitable relationships. You'll
look toward wealthier clients or develop a system for managing multiple small accounts in order to keep up your income levels.
Further, you'll need to get smarter about using technology and
integrating many of your back-office activities as profitability takes
center stage. Standardized processes could help you streamline both
service and support.
you have access to all investment solutions that
would fit your client base. That means you will
probably want to develop an optimum client
description and focus your marketing efforts on
those prospects.
You would also need a platform that would
allow you access to all the products you'd need.
For certification, you would need to prove to
an organizational body that you truly give independent advice.
Don't have a college degree? That could be
a problem. Also, 35 hours of continuing education is a high bar: Even if you are already a certified financial planner, that's more than double
your current requirement.
Now think about this: The United States has
been a leader in the development of financial
planning and investment advisory services, but
it isn't any longer. Given the global nature of the
financial services industry, I don't believe we
can sustain our current advisory services system into the future.
I believe that change is coming and we'd be
wise to take an active role in helping to design
our changes, rather than having them developed by people who don't know our business
models or our clients.
Look back now at the picture I've painted
for the future. Most of these changes would
actually be good business practices for
today, independent of the way you get paid.
These strategic decisions will help you create value for your clients, demonstrate your
professionalism and improve your bottom
I believe that professionalism is paramount;
we're no longer sales-driven but solution-driven. We're advisors, counselors and planners
who develop sound financial futures for our clients. Aren't we? FP
Deena Katz, CFP, is a Financial Planning columnist and an associate professor of personal
financial planning at Texas Tech University.
She is also chairwoman of Evensky & Katz, an
advisory firm in Coral Gables, Fla.
Click to subscribe to this magazine


text:
Grilled artichokes, stuffed mushrooms, etc
I tried a sequence tonight to practice getting the most out of a firing. While I was getting the WFO hot enough for pizza, I tried asudave's crab-stuffed mushrooms (thanks Dave!). Then I grilled some artichoke hearts on an iron grill. I had steamed them earlier in the day to soften, split in two length-wise, removed the choke, and drizzled with olive oil. Served those with some cucumber wasabi ranch dip. Right before bringing them in the house, I put a big log on the fire to really heat things up. 15-20 min later I cooked some pizzas. Then as the fire was dwindling I put in an 8 pound pork loin. I skewed it from each side and draped the skewers on the edge of a cast iron dutch oven. It cooked for 50 minutes, rotating once during cooking. Lastly, I cooked Frances' macaroons using cashews and pecans. Frances, they were delicious! Now I am going to put my feet up and sit down! If I had made bread earlier in the day I could have done that as well. I think I cooked all that using about six sticks of wood....wow.
Re: Grilled artichokes, stuffed mushrooms, etc
Great effort. I always feel guilty leaving it hot!
Re: Grilled artichokes, stuffed mushrooms, etc
Yep, me too.
My problem is that after pizza for lunch no one wants to eat anything much for the rest of the day. I run around saying things like "what about a roast for dinner?" or "hey, I could bake a cake", or "does anyone fancy macaroons again?" and all they do is groan in a overeaten sort of way... :confused:
Sounds like a great cookup Krosskraft! good use of the heat, and I'm glad you liked the macaroons.
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Have you ever used story cards as a reading alternative with children? My two and a half year old can't yet read, but she truly loves a good yarn, and these story cards turned out to be a really fun way to engage her in storytelling. For the past month or so, she's been enamored by this awesome set of cards, Tell Me a Story - Circus Animal's Adventure (Amazon link), a … [Read more...]
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text:
July 4, 2015
A new industry is moving into Covington County, which means employment opportunities for the area.
Advanced Airlift LLC is a new company making its debut in the aircraft parts and maintenance industries. Its customer base is primarily military and it's setting up shop in Covington County.
The company recently purchased the Swet's Building in Opp for the manufacturing of aircraft parts. It will start out with 15 to 20 new jobs paying an average wage of $14 dollars an hour.
Opp Mayor H.D. Edgar said, "It brings stability to our city that we lost when we lost all the textile jobs. It brings a sense of growth back to our city and it just means a lot to our community."
The company expects the number of jobs to increase to 100 by the year 2009.
In addition to their new facility in Opp, the company will also be adding additional jobs at the South Alabama Regional Airport.
Advanced Airlift broke ground for a maintenance hanger to perform repairs on helicopters and C130's for the Air Force. This facility will add 60 new, high skill, high paying jobs to the area.
Tuscon Roberts, president and CEO of the Covington County Economy Development said, "I think it's a benefit to the whole county. It's good for our economy, it's good for our housing down here; just really stimulates our economy, these kinds of jobs."
Roberts says construction of this faculty should be complete in about four months.
The new business will increase traffic at the airport by about 20 percent. The airport will be expanding the runway 1000 feet to be ready for when business takes off.
Roberts says the runway expansion should be completed in about nine months.
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text:
It's a fact, video sells!
Video statistics continue to show that web video is a great way to sell your product or services like never before. Here, we go through some facts and figures to show you why you should have video on your website. If you're not adding video to your e-commerce, your competition is.
Engage your customers…
There is no doubt that video is now the best way to engage and interact with your customers building long-term relationships and customer loyalty. Web videos on your website increases visitor time on page statistics. Compared to images, charts and graphics, web video engages your visitors and builds your brand like nothing else.
Higher ROI…
Studies have shown that web video can deliver a higher ROI compared to traditional paid advertising techniques such as PPC (Pay-per-click) or banner ads. According to Eyeblaster, video increased dwell rate time on ads by 20% and dwell time by 100%. Web video also increases brand awareness and brand loyalty.
Build customer loyalty…
As the online retail market develops, acquiring new customers is becoming tougher due to competition and more complex customer behavior. So repeat business and monetization is key for the online retailer to survive.
Web videos build brand loyalty, trust and engagement. According to a recent study by IMRG Cap gemini e-Retail, 13% of shoppers found video useful when purchasing products and 57% of this group act as brand advocates, actively informing others of the products and web sites they like.
Reduce returns…
Compared to images or text, video can be the best way to describe and inform your customers about your product before purchase.
For example your video shows how big your bag is when your presenter demonstrates putting the bag on over her shoulder compared to static images. Your customers get a much better idea of the size, colour, depth of the bag and the length of the straps.
The more your customer is informed about your products, the lower the number of likely returns or customer service calls to your call centre. Some retailers have reported a reduction of returns by 25% as a result of adding web videos. A minute of video is worth 1.8 million words according to Dr. James McQuivey of Forrester Research
Increased conversion rates…
Conversion rate is simply the calculation of the number of visitors to a web page on your site compared to how many actually completed a goal on that page.
For example, how many visitors purchased your new black dress on promotion last week? Your stats show that 1000 visitors visited your promotion page but only 100 visitors clicked the add to cart button on the page. So your conversion rate was (100 / 1000) * 100 = 10%. Not bad.
Statistics have shown that web videos can increase your conversion rate between 12%-115%. On average retailers have reported 30% increase. However, some retailers have reported 400%.
Beat your competition…
Web video for e-commerce is still in its infancy as retailers slowly begin to realize the full potential and cost effectiveness of video. By adding video to your website you are already getting ahead of your competition.
Changing consumer behavior
According to ComScore 80.1% of the UK Internet users watched video online in 2009. As online video begins to replace traditional TV for watching video and online video becomes more readily available your visitors will soon expect to watch video on your website. Retailers may begin to lose customers to their competitors because of a lack of video content demonstrating their products.
Go 2 Productions…
In the past 5 years, Go 2 has successfully designed and created hundreds of engaging web videos for a multitude of industries ranging from an average of 15 seconds to 2-3 minutes (recommended max). Whether it's motion graphics, 3D animation or something completely different, the quality of our work speaks for itself. Click
to visit our portfolio to see for yourself and call us on 1 866 408 5844 to discuss how we can help concept a web video or series of videos for your website.


text:
Death at Occupy Denton camp at University of North Texas (UNTgbg
Archive | Quicks
Mubarak Dead- Unconfirmed Reports
There are reports floating round that former Egyptian strong man Mubarak may have passed away. If these rumors are true then it represents yet another milestone in Obamas head long drive to make the world safe for Islamist terrorism Read these Related Posts:No Related Posts
Obama pays $153K for 6 Month Jobs
Hat tip Stuart Varney The Obama so called "Green Jobs Training Program" is yet another corrupt vehicle for Obama to steal money from taxpayers like you and me and funnel it to his crooked supporters. The "program" initially "trained" 80,000 people. Of those only 8000 got jobs. Of those only 1000 still had a job […]
Michelle Obama's Nobel Nominations !
Michelle Obama' new invention to get Noble nomination
Al Gore Telethon Replacemet for Water-boarding !
Pentagon, are telling us that the military and the CIA will use recordings of the Al Gores broadcast as a replacement for water-boarding.
Warren Buffett makes ILLEGAL investment in Bank of America
This is an illegal and immoral transaction
Breaking, good riddance Tim Pawlenty!
Tim Pawlenty drops out of the race, another neocon weapon gone!
Obma's Ramadan Iftan dinner
Obama hosted his Mualsim Ramadan Iftar dinner
Chicago Tribune "Dems must Dump Obama" We said it first!
Chicago Tribune, Obama's home town paper says "Dump Obama" on his birthday
Obama Campaign, "America is still standing I need 4 more years"
There will be many slogans, this is one of them


text:
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4.5 out of 5
Simplehuman semi-round sensor bin27 December 2012
"A bin? You're going to review a bin?" they asked, with a mixture of surprise and despair. Our reply came quickly, perhaps so quickly it seemed rehearsed: "Yes, because this isn't just any bin, it's special." It's made by a company called simplehuman,... >>


text:
Wilbert Lemon Brown
Position: G
Height: 6-2 Weight: 320 lbs.
Born: May 9, 1977 in Texarkana, TX
High School: Hooks
College: Houston (school history)
Weighted Career AV (100-95-...): 4 (9744th overall since 1950)
Sponsor this page for $5 and help Pro-Football-Reference.com provide this service. Your message will replace this ad.
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text:
Yes, my wifi iPad arrived via UPS at 9.30am today, 27 May! Ordered from UK Apple store 7.25am on day pre-orders started, 10 May.
Some international iPads arriving early, hundreds of thousands of US iPads already there
Several readers hit us up saying their iPads were already arriving, ahead of Apple's May 28 international release date (at least phase one of it, phase two is slated for July). Given the spread of 9 countries, its probably harder for Apple to keep their iron grip on delivery dates and still make sure customers get them when they're supposed to.
If your iPad did indeed arrive early, drop us a note in the comments and let us know where and when.
Google acquired mobile advertiser AdMob, meanwhile, says it's seeing up to 25% of existing US iPads -- the million+ Apple sold in the first month -- hitting their network from outside the US.
Does this mean Americans bought less than we thought, and international early adapters have already sated some of their fill, or that -- given the ongoing supply constraints -- that Apple is just going to sell as many as they can make in all the countries they can get them to?
We'll start finding out tomorrow as Apple Stores open early so those who didn't pre-order can try their luck in line, like Chris and friends in Australia (picture after the break).
Have something to say about this story? Leave a comment! Need help with something else? Ask in our forums!
Reader comments
Some international iPads arriving early, hundreds of thousands of US iPads already there
My iPad was delivered this morning to Epsom, Surrey, UK. Was a 64gb 3G model, ordered on May 10th whilst hanging out the top floor of an Italian villa trying to get a signal long enough for the order to go through!!
My iPad was in Ontario yesterday, and this morning it's in Memphis. With my luck, it's on it's way back to China!
Oh well, I can be patient.
My pre-ordered 32Gb arrived at 10:30 this morning. Bristol, UK :-)
An Apple fanboy friend in Hong Kong preordered a non-3G iPad to ship to me in the first week of launch. When I mailed it at the post office, the lady asked me if it was an iPad because she has seen at least 15 such packages shipped already. I know lots of iPads have been shipped internationally but 25% is beyond my imagination.
Oh Boy.
Ok, I called FedEx Canada, and my iPad is in Ontario, it arrived early this morning - and Fedex "Could" have delivered today....but!!!
They out me on hold, and said that Apple Canada called them and instructed them that under no circumstances were ANY ipads to be delivered prior to the 28th. So they said I'd get it before 12PM tomorrow, which is fine with me.
but wow, talk about controlling a launch.
UK iPad arrived today (27) at 10am complete with keyboard dock, camera kit, sim and extra charger
Pre-ordered iPad on the 10th. Scheduled for delivery in Montreal on the 28.
According to FedEX, it went from China to Anchorage to Menphis and as of now back to Anchorage!?! Got an email from Apple to say that it will not be delivered on the 28 as planned. So in short, I will not get it before next week.. Not cool...
3AM at the Montreal (Ste Catherine) Apple Store. Only 3 people in line so far!


text:
In an event where the celebrations are almost as entertaining and exciting as the action that create them, Phillip Laux (No.4 @ 103) was reserved and business-like similar to his performance. Laux scored five takedowns beating West Des Moines Valley's Jake Koethe, 12-3, in the 103-pound championship.
Laux avoided any demonstrations or leaps into a coach's arms and signed his bout sheet and left the mat area.
"I have to think of this as just another tournament," Laux said. "Even after the state tournament there is more work to be done."
His teammate Jack Hathaway (No.14 @ 125) didn't let anything slow him down, including head trauma. Hathaway complained of a possible concussion suffered during the first takedown in a 6-1 win over Bettendorf's Connor Ryan at 125.
Hathaway said he smacked heads with Ryan as he scored his first takedown and saw flashes, which persisted throughout the match. he was still able to add another escape and takedown.
"I tried to stay focused on the match though," Hathaway said. "It wasn't the toughest thing to do but it wasn't very easy either.
"I wanted it pretty bad. I worked my butt off this year."


text:
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Using CFL lights for flowering
- Please log in to reply
#1 Canute
- Members
- 1 posts
Posted 10 February 2008 - 05:08 PM
I'm thinking about either:
1. Using a lot of regular house CFLs for the entire grow. This would be cheap and easy to set up.
2. Using CFLs for the vegetative stage and switching to a HPS for flowering. This is far more expensive and a little harder to set up.
So I need to know if there's a way for a beginner grower to get a decent harvest using CFLs. Does anyone have experience with this? I'd obviously prefer option 1 but if it's not going to work then I'll have to go with 2.
Links to good grow guides and lighting guides would be greatly appreciated.
Thanks in advance.
- 0
#2 Guest_frmrboi_*
- Guests
Posted 10 February 2008 - 05:35 PM
SOG flowering with clones & CFLs is very do-able just start flowering as soon as the clones are rooted.
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#3 jetski
- Members
- 1,018 posts
Old hand
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Posted 10 February 2008 - 05:40 PM
regular household cfls will work just fine. but just remember to keep the plants short and keep the bulbs within a few inches of the canopy. building a framework of cfls around the plant will work well. use the highest wattage and as many as you can use. aim for at least 40watts per square foot of canopy and scrog grows can work nicely as you will need to move the lights less
if your going to use a handfull of small cfls buy this book, its a grow diary and its worth looking at
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#4 Skitzo42087
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Posted 10 February 2008 - 06:21 PM
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#5 jetski
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Posted 10 February 2008 - 06:27 PM
cheap as chips
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#6 Volksman
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Posted 11 February 2008 - 06:23 PM
So I'm with Jetski in that flouro's can really do a pretty dang good job. I'd just save some trouble and time and purchase one of the flouro setups. They really aren't that expensive and the bulbs have lasted me about a year a piece with near continuous operation. Then some day when I have the time and cash I'll upgade my whole setup to maybe a 400W HPS but that will entail good ventilation for temp control and a carbon filter.
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#7 jetski
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Posted 12 February 2008 - 01:52 PM
hey volksman, how much bud do you usually get from one of your 125w cfls?
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#8 Volksman
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Posted 12 February 2008 - 05:13 PM
I don't have a scale so that's the best estimate I can give you, but I can say with three large plants I've filled 6 1L glass jugs almost completely full and I'd guess each jug holds about 2oz of fluffy cut bud. So I'd guess my best run was about 10oz in a 6sqft closet with one 125W CFL. Then again those are just my estimates.
Edit: And on my last run I did 8 small plants which filled a little over half the grow room. I also kept them in pretty small pots but I'd guess I averaged a 1/4oz from each small plant and yeilded maybe two ounces overall. Not the best run but it was a set of extra clones I had. So adding it all up I'd guess again around 1oz per plant, maybe more for a good run.
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#9 jetski
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Posted 12 February 2008 - 06:41 PM
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#10 Volksman
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Posted 14 February 2008 - 08:00 PM
I would add that until I've got a scale I don't really know the exact amount. So it's an unconfirmed amount. A good amount though!
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#11 smokeyjay
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Posted 07 April 2013 - 11:19 AM
basically ive got a 1.2m x 1.2m x 2m tent , i have 1 light and 2 125w bulbs one white one red, was thinking of growing 3 plants with these..
i was told to go with auto flower seeds witch i have ordered.
i was thinking of getting some little cfl bulbs or maby getting a 300w dual spec or should the 125w cfl be ok for veg and i should just get another red bulb for the flower ???
any advice would be great......
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#12 the_dank_one
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#15 Doobie Brother
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Posted 21 April 2013 - 03:35 PM
I've got nothing against fluorescent lights, but I think fluorescent tubes (i.e. T5s) would work much better and cover a larger area than a CFL.
You may want to use T5s or T8s for seedlings, but go with CFLs for the rest. They are more efficient than tubes because they can be positioned where and how close you wish.
Just my 2cents...
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Air is water with holes in it.
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#17 my1952HD
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Posted 22 April 2013 - 04:17 AM
In the thread I try to give my reasons for going the route that I went along with warts and all. I learned a lot about flowering with large wattage CFLs using 65W input, 300 incandescent equivalent Watts output bulbs, as these were the largest bulbs that fit a medium or standard base... and I used twelve of them over 10 plants.
There is also a link to Doobie Brothers multi CFL grow. He uses lower wattage bulbs, but more of them.
Take a look at the thread and if you wish to discuss this further, let me know as I learned a lot and am willing to share... 52.
PS. The bulbs that I used are small compared to the bulbs that one can use if they use the larger mogul base such as this 200 Watt - 8U CFL. That's 200W input with an 850 incandescent Watt output.
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Another thing is Daniel Bryan. He got the MITB win and people thought they were ruining him, and then he got the belt and people have their knives out for when he loses the title. Great Blog!
I'm liking WWE right now, too. There was some horrible stuff going on back in the days that people miss so much right now and to be honest, I wouldn't say I was more entertained then than I am now. It's the same thing, really. WWE is always gonna do some stupid stuff every now and again. Things will never be perfect.. but the way things are going right now seems pretty good. I'm enjoying most of what's going on in the WWE right now. I can't complain just because WWE isn't doing things EXACTLY the way I would have done.
I completely agree. In fact, I was thinking of writing a blog on this very topic soon. I think it's too easy to point to lack of competition and say WWE is on cruise control. The fact is that people have selective memory about the past/attitude era and remember only the big time segments and major stars. Many people forget that much of WWE's content was just as bad back then (anyone else remember the Midian/Viscera tag team or the Mean Street Posse?). I believe WWE is exceptionally entertaining right now and happen to think they're doing the best job they've done in years.
I'm thinking the IWC is consistently unhappy because there's only one real game in town, and that's the WWE, which is clearly in cruise control because there's nothing to threaten them. There was some bitching and complaining in the IWC back when WCW was around, but not nearly as much..because you had two mainstream shows, both putting forth the best effort they could to beat each other out. There was real competition. Now, there's not. So whatever the WWE does, there's no real alternative...and you can't appease the masses because everyone has a different expectation.
Hogan not fit to fight Taker guys! Sting will be a Great match though!
Originally Posted by Theiconsting
I agree the stock of future main eventers in the E is really poor & i dont see anyone that has the ability to ever be a top guy in the E. But TNA has heaps of guys that are main event worthy
Realy? REALY?!?
Not a single guy in TNA who hasn't been a top guy in WWE could even remotely dream of being a top guy in the 'E.
WWE have The Miz, Alex Riley, Wade Barrett and Randy Orton who are all 30, equating to a good 10 years at the top. They also have Cena, Sheamus and Alberto Del Rio in their early to early-mid thirties, giving them at least 5 years, with Rey Mysterio and Christian only having a few years on them - Only Mysterio has ever had a high flying offense so he's the only one who's body has realy felt the extremes of wrestling and will retire before 40.
10 years believe it or not is a long time to make a dozen superstars.
ezekiel jackson over Fuecking rated
© 2011 eWrestlingNews, All Rights Reserved.


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Leipzig, Germany, October 15, 2008 – At the EUHA Congress in Leipzig, Phonak introduces Certéna and Versáta, two new product families based on the proven CORE platform. Together with the already available hearing systems Exélia and Naída, these new product families form a unique product collection to meet every client need, accommodating all levels of hearing loss, personal preferences and lifestyle.
The CORE Collection products provide user-friendly operation, a uniform fitting process for the hearing healthcare professional and unmatched sound performance. The innovative technology also enables all hearing system users to access the digital world of communication.
CORE (Communication Optimized Real-Audio Engine) is the microelectronic heart of the new hearing system generation from Phonak. With six high-performance processors and eight million transistors, the platform provides the necessary computing power for numerous high- tech functions for a greatly enhanced user experience.
CORE Collection overview: Certéna – Confidence in life
Certéna is the entry point into the CORE Collection and offers numerous high-tech functions. WhistleBlock Technology makes feedback a thing of the past: The modern technology precisely and reliably identifies and eliminates feedback without affecting natural signals. Wireless connection options and cable-free fitting complete the range of functions.
Versáta – Life in motion
The mid-priced Versáta product family is particularly suitable for users with a dynamic lifestyle. The SoundFlow Advanced automatic system, comprehensive wireless connection options, and excellent performance ensure clear sound, improved audibility and optimum comfort in various hearing situations. The hearing system adapts to the sound environment in real time. With SoundFlow, Versáta provides optimum audibility for a life with an ever-changing soundscape.
Exélia – Full life experience
Exélia, the first-class product of the CORE Collection, offers superior hearing performance, optimum hearing system control, and easy access to modern communication and entertainment technologies in stereo quality. ZoomControl allows users to individually adjust the hearing focus for the first time. This function facilitates communication in many daily situations, such as when driving a car. Exélia represents a quantum leap in hearing system technology – the acoustic performance and the interaction options of Exélia are unparalleled.
Naída – The power to change life
Naída brings new soundscapes to people with profound hearing loss. The innovative SoundRecover function of Naída restores high frequency audibility – even in the case of steeply sloping high frequency losses. This is essential for speech comprehension and for the perception of one's own voice. Naída thus helps to significantly improve user hearing and speaking capability. The high-performance hearing system offers the additional advantages of a slim design and a water-and dirt-resistant housing. Naída provides maximum freedom, comfort, and quality of life to people with profound hearing loss.
Wireless access to the digital world
The CORE Hearing instrument Body Area Network (HiBAN) allows people with hearing loss to take full advantage of the modern communication world for the first time. All CORE hearing systems can be easily connected via the iCom communication interface to external audio sources and devices such as cell phones, MP3 players, Bluetooth devices, and analog FM systems. In addition, the CORE technology allows binaural signal processing so that audio data can now be exchanged between two hearing systems in real time.
Cable-free fitting
The CORE platform even makes the fitting process more comfortable. iCube allows cable-free fitting by allowing wireless transmission of the data to the hearing systems. While the hearing healthcare professional adjusts the settings in real time, users can even leave the fitting room to experience real-life sounds. The need to select the correct cable is also completely eliminated. The result: Quick and easy fitting.
All CORE Collection products are compatible with a broad range of control options and accessories that can be assembled according to the user's desires. The hearing system models range from the smallest CIC systems to high-performance BTE systems and come in a variety of colors.
The new Certéna and Versáta product families are now available.
About Phonak
Headquartered near Zurich, Switzerland, Phonak has developed, produced and globally distributed state-of-the-art hearing systems and wireless devices for over 50 years. The combination of expertise in hearing technology, mastery in acoustics and strong cooperation with hearing care professionals allows Phonak to significantly improve people's hearing ability and speech understanding and therefore their quality of life.
Phonak offers a complete range of digital hearing instruments, along with complementary wireless communication systems. With 2'500 employees worldwide, Phonak drives innovation and sets new industry benchmarks regarding miniaturization and performance.
For more information about Phonak, please visit http://www.phonak.com/.


text:
Developer – Airtight Games
Publisher – Square Enix
Platforms – PC, PlayStation 3, Xbox 360
Developed by the esteemed Kim Swift, former lead designer of the first Portal game, Quantum Conundrum offers a clever approach to the puzzle genre that can be extended to a much wider, and especially younger, audience. The game falls short, however, due to the repetitious nature of the level design and a reliance on excessively frustrating platforming.
In Quantum Conundrum you play as an antisocial 12 year-old whose mother thinks the best cure for you is pushing you on your genius uncle. Each time you visit, your uncle has a new invention that he prominently displays before kicking you out of his house so he can get back to work. During this visit he unveils his greatest invention yet: the IDS gauntlet. Before he can show it off, something goes terribly wrong and your uncle becomes trapped in a pocket dimension with some inconvenient amnesia. Now it is up to you to take hold of the IDS device and use its abilities to fix the power in the manor, hopefully restoring your uncle to your own plane of existence.
The gameplay is very much the same as one would expect from the designer of Portal. The player starts by grabbing an interdimensional device and then uses it to solve a variety of puzzle rooms divided by non-puzzle sections (the elevators of Portal reflect the hallways here). Over time the player gains the ability to shift into new dimensions: Fluffy dimension makes everything weigh ten times less, Heavy ten times more, Slow makes time pass in slow-motion, and Reverse Gravity reverses gravity (or is built upside-down).
None of these dimensions affect the player, making it possible to pull off complicated platforming maneuvers. Many of the puzzles are very interesting and fun but despite their cleverness, they tend to be too easy to solve. Most of the time the solution is very clearly ascertained, and when it is not, clues tend to be given to the player. This makes what could be a fun puzzling experience somewhat dull. Furthermore, it means the game relies not on solving puzzles, but on complicated platforming to make things difficult. In certain situations you have to go in and out of several dimensions while on moving objects and you have to navigate around laser beams and pipes (whilst throwing other objects you then have to get on top of). While the solution is obvious, it may take the player 10-20 minutes to get through a section, simply because of how complicated the maneuvering is. Needless to say, this can make the game more frustrating than fun.
Where the game still wins is through its quirky sense of humor and an abundance of witty jokes. While there is little dispute that uncle Quadwrangle is disagreeable at best, he makes up for it with science-y humor. Even the dying messages and loading screens are pretty funny if you are in the right moods. Furthermore, objects, particularly paintings, can change depending on the dimension you are in, which leads to some interesting and funny effects.
The graphics of the game are good for the cartoony nature that the developers were trying to create to appeal to younger players. After a player has gone through several rooms though, there is no longer any real variation on the type of aspects that are in the room, and the player quickly becomes accustomed to them. One or two new structures are added in the final level set, but then these are repeated for that entire set, leading to the same problem. While a comparison to Portal may not be fair, it was clear that even though Portal was set up in a series of similar rooms, the player was excited to move on to the next segment as the player didn't know what to expect. This is felt especially when the player escapes outside of the testing chambers. In Quantum Conundrum, this is hardly felt at all, as each level's graphics are very repetitive.
If recycled graphics are annoying, then repetitive sounds are doubly so. There are few things that make puzzling more frustrating than such sounds and Quantum Conundrum is ripe with them. There are actually collectibles that do nothing but repeat annoying sounds over and over again, making their collection more of a necessity because it is the only way to shut them up. The small fluffy creature, Ike, has the same problem. He is already pretty annoying as he steals all of the batteries you need to power dimensional shifts and puts them in inconvenient locations, but he also makes the most irritating sounds whenever he is close or you take a battery from him. Combine this with the persistent background sounds of chattering glass, a cow mooing, and a door slamming and one cannot help but get frustrated. Despite this, the music in the game is well done, and is perfect for the type of game it is attached to.
In terms of replay value, there isn't much. There are time-trials, rewards for not dying in a level, and collectibles that can be found throughout the game but these only serve to give the player achievements. The levels are consternating enough without such things. I was excited at first to find that certain collectibles unlock dimensions in an R & D Lab, but then was quickly disappointed when I realized the room is just for fooling around with the physics of the game.
Overall, Quantum Conundrum is a solid puzzle game, and certainly suited for children in addition the older gaming crowd. At the same time, the platforming and repetition detract greatly from the game making replay undesirable. It is worth playing once and buying at its Steam price of $14.99.


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Nine-Run Second Propels Memphis to 15-3 Win at Houston
May 17, 2012
HOUSTON, Texas - Memphis (27-26, 12-10) recorded a season-high 23 hits and a nine-run second inning was all they needed in a 15-3 defeat of Houston (17-31-1, 5-16-1) on Thursday night at Cougar Field.
Memphis collected two hits in the top half of the first, but failed to advance the runners from first or second with one out in the frame. Houston produced one run with runners on and two outs, but a caught stealing with runners on the corners helped Memphis get out of the inning. Landon Appling led the inning off for the Cougars and scored on a RBI single by Chase Jensen, but Jensen was caught stealing to end the first.
The Tigers responded with a nine-run outburst to take a commanding 9-1 lead. Memphis pounded out the nine runs on nine hits, including three doubles. Houston faced 13 batters in the inning and after a leadoff groundout, Memphis had six-straight hits to score five runs. Bryce Beeler had a three-RBI double, Keaton Aldridge drove in two with a double and Ethan Gross, Jacob Wilson and Ford Wilson each added one RBI in the inning.
Dan Langfield faced trouble even though he held a 9-1 lead, but he managed to strand the bases loaded in the second and third inning while allowing one run on a wild pitch. In the second, the bases were juiced with one out, but a strikeout and ground ball ended the inning. Langfield allowed two hits and hit a batter to load the bases before a wild pitch allowed the Cougars second run to score. A walk loaded them up again, but Langfield notched his fourth strikeout of the game to end the inning.
After leaving three runners in scoring position over the third and fourth innings, Eli Hynes laced a single up the middle to increase the Tigers lead to 10-2. Memphis added two more runs in the sixth on a RBI double by Ford Wilson and Jacob Wilson drove in another with a single to center. Houston used a solo home run by Jake Runte to make the score 12-3.
The Tigers added three runs in the seventh to increase the lead to 15-3. Hynes was hit by a pitch and Derrick Thomas reached on a bunt single. T.J. Rich singled to left field and two runs scored after the ball got away in left field. Pinch-hitter Tucker Tubbs followed with an infield single to drive in Rich and with the two recording hits, 10 different Tigers had hits for the second-straight game.
Eight of the nine starters recorded multiple hits in the game and four different players had three or more hits. Ford Wilson led the club with four hits and Gross, Jacob Wilson and McClain posted three hits each. Michael Wills (4-1) pitched five innings in relief and allowed one run on four hits to notch the win. Wills win marked the sixth for the bullpen in the last 13 games and the bullpen sports a 1.88 ERA in those games.
After a 13-3 win on Tuesday versus UT Martin, Memphis' 12-run win marks only the second time since 1996 that the U of M has won back-to-back games by 10 or more runs. The back-to-back 10-plus run victories mark the ninth time in the same span that the Tigers have won back-to-back games with a plus-20 run differential. The 15 runs scored in a C-USA road game are the most for the U of M since a 21-13 win at Marshall on April 3, 2010. The Tigers collect just their second win at Cougar Field and improved to 2-20 all-time against Houston at Cougar Field.
The Tigers and Cougars meet for game two of the series on Friday at 6:30 p.m.


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Class of 2011 Medical Students Celebrate Coe Distinction
On Wednesday, March 2, students, family and faculty celebrated the Class of 2011 recipients of the Rodney M. Coe Distinction in Community Service.
This distinction program, one of only two distinction programs in the school, is awarded upon graduation, following the completion of a four-year program of community service, faculty-guided reflection and integrative workshops at Saint Louis University School of Medicine.
The program is sponsored by the department of family and community medicine and the Saint Louis University Area Health Education Center, and it is designed to promote a reciprocal, beneficial relationship between the student and the community that results in both professional character development and increased community health.
The Coe program provides service learning opportunities for medical students to develop a familiarity with the context of and interventions applied to communities and community health issues in order to acquire skills, compassion and understanding, and thereby developing leadership abilities necessary for successful work in the community.
In addition to the actual community service, students develop skills in formal written critical reflection based on service and program objectives. In the fourth year of the programs, each student, together with one of the Coe directors and community agency leaders, develops and implements a program, service or tool identified by the agency as a need of the agency or service population.
The first cohort of students with this distinction graduated in 1995. The program currently has approximately 100 students spread over the four years of medical education.
The following students will receive a Medicinae Doctoris with distinction in community service at University commencement May 21. Their fourth-year projects, which were presented at the March 2, Coe reception, follow their names.
- Julie Berg and Krystal Vasoya: Interactive Health Education: Health Fair at Woodland Elementary School
- Amy Bilyeu and Thomas Heafner: Area Health Education Center: Mentoring Program: A Three Year Mentoring Model
- Christopher Britt: Establishing a Vitals Clinic at the Health Resource Center
- Jaclyn D'Orazio: Area Health Education Center: East Central Missouri Strategic Planning Project
- Sarah Maufe: Health Care for Haiti
- Jasjit Kaur Mudhar and Mansi Patel: SLU for Sight
- Preethi Rangacheri: Eating Healthy on a Budget
- Kristina Raveendran: Establishing Measurable Criteria for Effective Care of Hospice Patients with Dysphagia, Disability or Dementia
- Nicholas Stahlschmidt: Know Your Meds: Patient Education and Medication Reconciliation at Grace Hill Health Center
- Tabitha Townsend: Talking With Your Provider: A Health Literacy Project Aimed at Adolescents (Maplewood-Richmond Heights School District)
For more information about the Coe Distinction in Community Service Program, contact one of the three program directors:
Fred Rottnek, M.D., MAHCM
David Pole, MPH
Kelly Everard, Ph.D.
All three can also be reached through the department of family and community medicine at 314-977-8480


text:
Privacy and Cookies
British Airways' and Iberia's shares have been cancelled from the stock exchange after the merged companies began trading today as the International Consolidated Airlines Group.
In early trading the shares stabilised at around £2.85 ($4.55), down slightly on their debut.
IAG chief executive Willie Walsh, outgoing head of BA, is convinced that the move elevates the two partner carriers into the big time and will provide a springboard for even greater things.
"This creates for Europe a third major force in world aviation," says Walsh, who famously revealed last year that he had drawn up a list of potential future partner airlines.
"IAG's strategic ambition is to provide a platform that is attractive to other like-minded airlines to join us," he says.
Assisting Walsh at the helm is former Iberia chief executive, and now IAG chairman, Antonio Vazquez. He sees the link-up as vital to ensure both airlines remain competitive in the long-term.
"Both companies now have the feeling that working together everything is possible, because we have a much broader way of looking at the world," he says.
The Oneworld alliance-aligned group, which began trading on the London and Madrid stock exchanges today, may be a new "superpower" but it can't yet rival Europe's other two giants Air France-KLM and Lufthansa, on paper.
Like Air France and KLM, BA and Iberia continue to operate as separate entities, but their combined traffic - based on last year's World Airline Rankings for fiscal 2009, from ATI sister publication Airline Business - means it is placed sixth behind its two European opponents.
In terms of revenue, IAG lies seventh in the rankings while its fleet of some 340 aircraft puts it eighth. It trails Air France-KLM and Lufthansa on both metrics.
But the merger isn't all about size, points out Vazquez. "We expect to achieve €400 million in annual cost savings by year five through synergies - one third from revenue and two thirds from cost," he says.
There is a good fit between the two airlines' long-haul networks, with BA's strength on the North Atlantic complemented by Iberia's powerful presence between Europe and Latin America. Added to this is the recently awarded anti-trust immunity awarded to Iberia and BA - along with Oneworld partner American Airlines - for their transatlantic business. The partners are already beginning to reap the benefits from this.
There is also some fleet commonality - both carriers fly Airbus A320s on their short-haul network - and this will be further enhanced when IAG uses its buying power to negotiate a huge joint deal for new long-haul types to replace BA's Boeing 747-400s and Iberia's older A340s.
Walsh and a small team of dedicated IAG staff have taken up residency on the edge of London Heathrow, down the road from his old office at BA's Waterside headquarters. Walsh will also have a presence in Madrid, as will Vazquez.
BA's former chief financial officer Keith Williams succeeds Walsh at BA, while Iberia's former chief operating officer Rafael Sánchez-Lozano takes over from Vazquez at the Spanish flag-carrier.


text:
Should Jim Carrey have stuck with 'Dumb and Dumber To'?
June 26, 2012 in Grand Forks Herald
Details on the exact dispute between Jim Carrey and New Line over "Dumb and Dumber To" may not emerge for a few days. But no matter what went down, it's a blow to Carrey's career that he won't be reprising the Lloyd Christmas role and doing the movie. Continue Reading


text:
IOWA CITY, Iowa The Iowa Hawkeyes are now taking nominations for Kid Captains for the upcoming football season.
Current and former patients of the University of Iowa Children's Hospital are eligible to become a Kid Captain during a Hawkeye football game. The program, in its 4th year, honors patients and celebrates their survival stories.
Each Kid Captain will be introduced at midfield before Hawkeye home games or get a special recognition before an away game.
Nominations are due by April 15.
For more information or to nominate your child, please click here
Cedar Rapids, Iowa News, Sports, and Weather
Hawkeyes Looking for Kid Captains
Most Popular


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Department of Biology
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Medical School
What courses should you take?
The MCAT is a comprehensive exam that tests you in four areas: Verbal reasoning, Physics and Chemistry, Essay writing and Biology. While your undergraduate classes will give you most of what you need for the MCATs you should plan to invest a considerable amount of time preparing for them. You will need to be familiar with chemistry through organic/biochemistry, as well as the full range of physics. Do not expect to do well without spending a lot of time studying these areas. The Kaplan courses are recommended by many students but they are expensive and still require you to do the work on your own.
Medical/Volunteer work
By clicking on one of the links below, you will be leaving the Eastern Connecticut State University - Biology Departments website. All information provided to you from these linked website does not necessarily reflect the policies of the University. The University is not responsible for the content of any links that you may follow from this server beyond this point.


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