text: NNPA Hosts Historic Conversation Between Reverend Al Sharpton and Dr. Cornel West Written by Super User 01 July 2011 CHICAGO, IL. – Moderated by nationally syndicated journalist George Curry, Reverend Al Sharpton and Dr. Cornel West came together in Chicago to discuss "Blacks in the Age of President of Obama." ... read more >> A Warrior Passes Written by Sentinel News Service 01 July 2011 George Beaubian Beaubian (l) with his colleagues receiving the Brotherhood Crusade Medal of HonorThe Brotherhood Crusade Medal of Honor George Beaubian has been a leader in the community for almost five ... read more >> The 1912 Tulsa Riots Written by Ismail Muhammad (Intern) 01 July 2011 Looking Back at a Shameful Moment in American HistoryBy Ismail MuhammadSentinel InternIt began in the early evening of May 31, 1921. Rumors floated around Greenwood, an African-American enclave of Tulsa, ... read more >> Parks Sworn – in for 3rd Term as Eighth District Councilmember Written by Jason Lewis (Sports Editor) 01 July 2011 Councilmember Bernard C. Parks took the oath of office for his third and final term on the Los Angeles City Council. City Clerk June Lagmay swore Parks in, as family, friends and staff members gathered ... read more >> Debra Reid Fights for Parent's Rights Written by Jason Lewis (Sports Editor) 01 July 2011 By Shirley HawkinsSentinel Contributing WriterIt was a parent's worst nightmare.Fourteen years ago, Gardena resident and mother of four Debra Reid was awakened at 1:30 a.m. by a phone call."A nurse from ... read more >> Local family wins Verizon Wireless Sweepstakes! Written by Brian W. Carter (Staff Writer) 30 June 2011 A surprised Lathern family wins!Left to Right: Christina Gonzalez, Associate Director Multicultural Marketing for Verizon, Yolanda Lathern, Johnny Lathern, Emma Lathern, Valerie Lathern, Dorothy Lathern, ... read more >> Blacks in Auto sports: Changing the game Written by Brian W. Carter (Staff Writer) 30 June 2011 Strong RacingLogan RacingDavid LambertLambert on the trackFrom Left to Right: David Lambert, Pro Racer, Dr. James Logan, owner of Logan Racing, & Erica Abdullah Hill, co-owner of Strong Racing and ... read more >> Wesson's Movie Showing a Huge Success Written by Jason Lewis (Sports Editor) 30 June 2011 Councilman Herb Wesson with a young constituentCouncilmember Herb Wesson's 2011 "Free Summer Movies in the Park" series was launched last week at the Baldwin Hills Recreation Center, where over 300 community ... read more >> Millage Peaks Announces Retirement Written by Ishmail Muhammad (Contributing Writer) 30 June 2011 Chief Millage Peaks The City's Second African-American Fire Chief will retire after leading the department for two years. By Ismail MuhammadSentinel InternThe Los Angeles Fire Department's Chief Millage ... read more >> NNPA Displays Black Power Written by Jasmyne A. Cannick (NNPA National Correspondent) 30 June 2011 National Black leaders gather for the National Newspaper Publishers Association annual conference in Chicago Fri., Jun. 24. (L to R) Dr. Cornel West, Dr. Maulana Karenga, Rev. Jesse Jackson Sr., Danny ... read more >> Same Men of Song and Music Written by Yussuf J. Simmonds (Managing Editor) 25 June 2011 Nat "King " Cole James Brown and Michael JacksonStevie WonderLegendsBy Yussuf J. SimmondsSome men of song and music"Nat King Cole, James Brown, Michael Jackson & Stevie Wonder"NAT KING COLE"His voice ... read more >> Boxer Statement on President Obama's Speech on Afghanistan Written by Super User 24 June 2011 Boxer Statement on President Obama's Speech on Afghanistan Washington, D.C. – U.S. Senator Boxer (D-CA) issued the following statement after President Obama's speech tonight on the U.S. role in ... read more >> Twins overcome and accomplish Written by Brian W. Carter (Staff Writer) 23 June 2011 Shannon and Sharron BowensShannon and Sharron Bowens achieve high academic success and blaze an inspiring trailBy Brian W. Carter, Sentinel Staff WriterThere are times when life takes a turn and leaves ... read more >> Wesson Takes 'Oath of Office' for 2nd Term Written by Jason Lewis (Sports Editor) 23 June 2011 Herb Wesson takes the oath of office administered by City Clerk June Lagmay while his wife, Fabian looks onThe 10th Council District's annual "City Employee Appreciation Luncheon" Thursday was the scene ... read more >> Compton School Board Member Micah Ali Met with President Obama Written by Sentinel News Service 23 June 2011 Last Friday, Micah Ali, a member of the Compton Unified School District Board of Education, traveled to Washington, D.C. Friday to meet with members of the Obama administration and attend an intimate ... read more >> Assemblymember Isadore Hall Announces Campaign for Congress Written by Ismail Muhammad (Contributing Writer) 23 June 2011 Assemblyman Isadore Hall California State Assemblymember Isadore Hall announced his campaign for Congress today. Hall intends to run in a new Congressional District, which according to the first draft ... read more >> NNPA Converges on Chicago Written by Yussuf J. Simmonds (Managing Editor) 23 June 2011 Rev Jesse Jackson Dr. Maulana KarengaRev. Al SharptonCongressman Emanuel Cleaver Professor Michael and Rev. Marcia DysonBenjamin JealousGeorge CurryBenjamin ChavisDanny J. Bakewell Sr.Dr. Frederick Haynes ... read more >> Sharpton and West to Debate: At Black Newspaper Conference in Chicago Written by Jasmyne A. Cannick (Columnist) 21 June 2011 National Black Leaders including Rev. Jesse L. Jackson Sr., Dr. Maulana Karenga, Dr. Benjamin Chavis, Benjamin Todd Jealous, and Dr. Michael Eric Dyson to join Over 200 Black Newspaper PublishersNNPA The ... read more >> Mother Helen A. Davis Passes at 102-Years Written by Sentinel News Service 18 June 2011 Mother Helen A. Davis102-YearsMother Helen A. Davis has made her transition. An avid reader of the Los Angeles Sentinel for 60 years, Mother Davis passed away at the age of 102 years old. Her Homegoing ... read more >> Founder of Project Fatherhood dies at 72 Written by Sentinel News Service 18 June 2011 Dr. Hershel K. Swinger passes on eve of 4th Annual Fatherhood Solution ConferenceDr. Hershel K. Swinger, Ph.D., founder of Project FatherhoodSM, the renowned program created to address the problem of absentee ... read more >> Cora King Succumbs Written by Sentinel News Service 18 June 2011 Cora KingDecember 23, 1919-June 10, 2011Mrs. King was a leader in the Los Angeles community. Mrs. King began her career in fashion working in the movie studios in design. She then transition into real ... read more >> Honor Thy Father Written by Yussuf J. Simmonds (Managing Editor) 18 June 2011 *** Legends ***By Yussuf J. SimmondsHONOR THY FATHER"Fathers led the way; daughters followed"MUHAMMAD ALI/LAILA ALIHe was a three-time world heavyweight boxing champion, a social and religious activist ... read more >> Wade Joins L.A. Leaders to Prepare for NAACP Convention Written by Cora Jackson – Fossett (Religion Editor) 17 June 2011 Rev. Melvin Wade. When the NAACP comes to Los Angeles next month, the Rev. Dr. Melvin Wade will be at the forefront of the executive contingent, ensuring that the 102nd Annual Convention is a success. ... read more >> U.S. Delegates Visit Alan Gross in Cuba Jail Written by Associated Press 16 June 2011 The American contractor was sentenced in March to 15 years in prison after being convicted of bringing communications equipment into Cuba illegally.By The Associated PressMembers of a visiting United States ... read more >> $1.25 Billion Class Action Settlement Begins for Black Farmers Written by Sentinel News Service 16 June 2011 Official Notification of African American Farmers About $1.25 Billion Class Action Settlement Begins Washington, DC--The Court-ordered process of officially notifying African American farmers and their ... read more >> Page 107 of 198 StartPrev102103104105106107108109110111NextEnd Subcategories Breaking News Campaign Watch Celebration of Life Exclusive International Legends Local National Politics Press Releases


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Ingenuity goes a long way toward compensating for lack of capital, an axiom Kenneth Cole proved back in the early 1980s when he launched his fledgling shoe store out of a borrowed truck parked along a fashionable Midtown Manhattan street. Gaining a parking permit required a clever ruse. Cole added the word "Productions" to his company name, reinvented himself as a film director, hired models as "actors," and got a license to shoot a film appropriately titled The Birth of a Shoe Store. Kenneth Cole Productions, Inc. (the tongue-in-cheek name remains to this day) may not have produced much actual film that day, but it did sell an impressive number of shoes. Since those early years, Kenneth Cole has expanded its product line, adding high quality clothing, accessories, and watches, all of which are infused with the same great contemporary urban style.
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|Analog Analog An Analog refers to the type of dial. Typically an analog watch has an Hour, Minute and Second Hand markers.
|Quartz Quartz A quartz movement, usually the most accurate type of movement, uses a battery for its power source.
|Mineral Mineral Hardened crystal or glass that gives a protective barrier. There are multiple variations but most are scratch resistant and durable.
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|Stainless steel Stainless steel Stainless steel is a heavy, durable metal that is moderately scratch resistant. Brushed Silver is the most common color, though the metal can be plated for different colors.
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Research Output for Deborah Hennesey
Note: The 2012, 2013, 2014, 2015 publications have not been audited.
Jump to: Publications | Grants and Consultancies | HDR completions
Deborah Hennesey may be from another institution or only recently joined Deakin University.
2009 External
Kline, Jodie, Hennesey, Deborah*, Petidis, Angela*, Charles, Elizabeth* and Gunning, Lynne* (2009) The AEDI: Adaptation and use for children with language backgrounds other than English, in unknown (ed.), FECCA 2009 : Strengthening Multiculturalism and Building Social Inclusion : Federation of Ethnic Communities' Council of Australia Conference, Federation of Ethnic Communities' Councils of Australia, Brisbane, Queensland [EN.1]
DRO entry for this publication
Grants and Consultancies
No grants and/or consultancies found or audited – the 2014 HERDC financial return has not been completed or loaded as yet.
Higher Degree by Research Completions supervised by Deborah Hennesey
No completions found or audited.
- Legend:
- * Not a member of Deakin University at time of output.
DRO to publications collection last synchronised: Saturday 30th May 2015 10:04pm


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Novel assays that quantitatively measure total HER2 protein expression and homodimers have been developed in an effort to improve the accuracy and consistency of HER2 testing.
The HER-family of receptor tyrosine kinases (EGFR/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4) plays a major role in the pathogenesis of many solid tumors. In approximately 25-30% of breast cancers, overexpression of HER2 has been linked to shorter disease-free (DFS) and overall survival (OS), lack of responsiveness to tamoxifen antiestrogen therapy and altered responsiveness to a variety of cytotoxic chemotherapy regimens.
Trastuzumab, a monoclonal antibody directed at the extracellular domain of HER2 has offered significant DFS and OS advantages in the metastatic and adjuvant settings in HER2-overexpressing patients, although not all patients respond. Fewer than 50% of patients with metastatic HER2-positive breast cancer show initial benefit from trastuzumab treatment, and many of those eventually develop resistance. (1)
Current methodologies for the selection of HER2-positive patients include immunohistochemistry (IHC) to detect HER2 protein overexpression, and fluorescence in situ hybridization (FISH) to detect HER2 gene amplification. However, controversy still exists regarding the accuracy, reliability, and interobserver variability of these assay methods. IHC provides a semiquantitative measure of protein levels (scored as 0, 1+, 2+, and 3+) and the interpretation may be subjective. FISH is a quantitative measurement of gene amplification, in which the HER2 gene copy number is counted. However, FISH, which is considered to be more quantitative analytically, is not always representative of protein expression, and multiple studies have failed to demonstrate a relationship between HER2 gene copy number and response to trastuzumab. Whereas patients who overexpress HER2 protein (IHC) or show evidence of HER2 gene amplification (FISH) have been shown to experience better outcomes on trastuzumab than those scored negative by those assays, differences in the degree of expression or amplification by these methods have generally not been shown to discriminate between groups with different outcomes. IHC and FISH testing may be affected by interlaboratory variability, and neither test provides quantitative data that reflect the activation state of signaling pathways in tumors, which may limit their utility in patient selection. (2) Most laboratories in North America and Europe use IHC to determine HER2 protein status, with equivocal category results (2+) confirmed by FISH (or more recently by chromogenic in situ hybridization [CISH]).
Normally, HER2 activates signaling pathways by dimerizing with ligand-bound EGFR-family members such as HER1 and HER3. A HER2 ligand has not been identified, but overexpressed HER2 is constitutively active. When HER2 is pathologically overexpressed, the receptor may homodimerize and activate signaling cascades in the absence of the normal regulatory control imposed by the requirement for ligand binding of its heterodimerization partners.
A novel assay (HERmark® Breast Cancer Assay, Monogram Biosciences, South San Francisco, CA) was developed to quantify total HER2 expression and HER2 homodimers in formalin-fixed, paraffin-embedded tissue samples.
Regulatory Status
U.S. Food and Drug Administration (FDA) does not regulate in-house or "home brew" tests for HER2, tests developed and used at unique or individual laboratory sites.
The HERmark assay has been validated according to the specifications prescribed by the Clinical Laboratory Improvement Amendments (CLIA) and is performed in a College of American Pathologists-certified clinical reference laboratory at Monogram Biosciences.
Each benefit plan, summary plan description or contract defines which services are covered, which services are excluded, and which services are subject to dollar caps or other limitations, conditions or exclusions. Members and their providers have the responsibility for consulting the member's benefit plan, summary plan description or contract to determine if there are any exclusions or other benefit limitations applicable to this service or supply. If there is a discrepancy between a Medical Policy and a member's benefit plan, summary plan description or contract, the benefit plan, summary plan description or contract will govern.
Blue Cross and Blue Shield of Montana (BCBSMT) considers the assessment of HER2 status by quantitative total HER2 protein expression and HER2 homodimer measurement experimental, investigational and unproven.
Technical performance of the assay
The HERmark assay was based on a proprietary technology platform that enables quantification of proteins and protein-protein complexes through the release of a fluorescent tag (VeraTag reporter, Monogram Biosciences) conjugated to specific HER antibodies, requiring proximity to a second HER antibody (so-called proximity-based technology).
The HERmark assay is currently commercially available only for quantification of HER2 total protein expression (H2T) and HER2 homodimers (H2D). The company plans to validate use of the test to measure HER heterodimers.
HER2 protein quantification was normalized to tumor area and compared to receptor numbers in 12 human tumor cell lines determined by fluorescence-activated cell sorting, and with HER2 immunohistochemistry (IHC) test categories and histoscores in cell lines and in 170 human breast tumors. (2) In contrast to conventional IHC test categories, the HER2 protein levels determined by VeraTag assay represent a continuous measurement over a dynamic range greater than 2 log10, and HER2 homodimer levels were consistent with crosslinking and immunoprecipitation results.
Huang and colleagues compared results of the HERmark assay with those of IHC and fluorescence in situ hybridization (FISH) centrally performed at the Mayo Clinic in 237 archived formalin-fixed, paraffin-embedded (FFPE) breast cancers. (3) IHC had already been performed at the time of initial diagnosis in all of the cases but was repeated for the purpose of this validation, and interpreted by one reviewer and scored as negative, equivocal, or positive according to the American Society of Clinical Oncologists/College of American Pathologists (ASCO/CAP) guidelines. (4) Reflex FISH for HER2 gene amplification had also been performed at the time of initial diagnosis on all 94 of the IHC 2+ cases. Repeat FISH was performed at the same laboratory and an overall evaluation performed by one pathologist. Of the 84 cases in the immunohistochemically negative subgroup, 80 (95%), 2 (2%) and 2 (2%) were classified as negative, equivocal, and positive by HERmark, respectively. Of the 101 cases in the immunohistochemically equivocal subgroup, 33 (32.7%), 31 (30.7%), and 37 (36.6%) were classified as negative, equivocal, and positive by HERmark, respectively. Of the 52 cases in the immunohistochemically positive subgroup, 1 (2%), 3 (6%), and 48 (92%) were classified as negative, equivocal, and positive by HERmark, respectively. The overall concordance was 67%, with a weighted κ of 63% (95% confidence interval [CI]: 55-70%) calculated using the κ statistic. When the equivocal cases were excluded from the HERmark and immunohistochemical results, the positive and negative concordance between HERmark and central immunohistochemical testing was 98%. The overall concordance was 98%, with a κ of 95% (95% CI: 89-100%).
Reflex FISH was performed on 94 breast cancers that had been determined as 2+ immunohistochemically at the time of initial diagnosis. Variable H2T and H2D levels were correlated to corresponding results for the HER2/centromere 17 (HER2/CEP17) ratio. Of the 94 cases that were 2+ immunohistochemically, 62 (66%), 5 (5%), and 27 (29%) were determined at the same central laboratory as negative, equivocal, and positive by FISH, respectively. Of the 62 FISH-negative cases, 24 (39%), 21 (34%), and 17 (27%) were determined as negative, equivocal, and positive by HERmark, respectively. Of the 5 FISH-equivocal cases, 1 (20%), 2 (40%), and 2 (40%) were determined as negative, equivocal, and positive by HERmark, respectively. Of the 27 FISH-positive cases, 3 (11%), 6 (22%), and 18 (67%) were determined as negative, equivocal, and positive by HERmark, respectively.
How well does HERmark predict subpopulation response to trastuzumab?
Bates and colleagues measured HER2 protein expression (H2T) in formalin-fixed, paraffin-embedded primary breast tumors from 98 women treated with trastuzumab-based therapy for metastatic breast cancer. (5) Using subpopulation treatment effect pattern plots, the population was divided into H2T low (H2T <13.8), H2T high (H2T ≥68.5), and H2T intermediate (13.8 ≤H2T<68.5) subgroups. Kaplan–Meier (KM) analyses were carried out comparing the groups for time-to-progression (TTP) and overall survival (OS). Cox multivariate analyses were carried out to identify correlates of clinical outcome. Bootstrapping analyses were carried out to test the robustness of the results. TTP improved with increasing H2T until, at the highest levels of H2T, an abrupt decrease in the TTP was observed. KM analyses demonstrated that patients with H2T low tumors (median TTP: 4.2 months; hazard ratio [HR]: 3.7; p<0.0001) or H2T high tumors (median TTP: 4.6 months; HR: 2.7; p=0.008) had significantly shorter TTP than patients whose tumors were H2T intermediate (median TTP: 12 months). OS analyses yielded similar results. The authors concluded that patients with very high levels of H2T may represent a subgroup with de novo resistance to trastuzumab but that these results were preliminary and require confirmation in larger controlled clinical cohorts.
Joensuu and colleagues reported the results of measurement of total HER2 content (H2T) using HERmark from formalin-fixed tumor tissue of 899 women who participated in the FinHer trial (ISRCTN76560285) to determine if very high tumor total HER2 content influences outcome in early breast cancer treated with adjuvant trastuzumab plus chemotherapy. (6) In a chromogenic in situ hybridization (CISH) test, 197 (21.9%) patients had HER2-positive cancer and were randomly assigned to receive trastuzumab or control. Tumor H2T levels varied greatly, by 1,808-fold. High H2T levels strongly correlated with a positive HER2 status by CISH (P < 0.0001). Patients with very high H2T (defined by ≥22-fold the median of HER2-negative cancers; 13% of CISH-positive cancers) did not benefit from adjuvant trastuzumab (HR: 1.23; 95% CI: 0.33-4.62; p=0.75), whereas the rest of the patients with HER2-positive disease by CISH (87%) did benefit (HR: 0.52; 95% CI: 0.28-1.00; p=0.050). The authors concluded that patients with HER2-positive breast cancer with very high tumor HER2 content may benefit less from adjuvant trastuzumab compared with those whose cancer has more moderate HER2 content.
Toi and colleagues investigated the relationship between quantitative measurements of HER2 expression (H2T) or HER2 homodimers (H2D) and OS in a clinic-based population of 72 patients drawn from 6 oncology clinics in Japan who had metastatic breast cancer and had been treated with at least one chemotherapy regimen prior to receiving trastuzumab. (7) Patients were originally selected for treatment with trastuzumab by IHC (88%) or FISH (12%). HERmark assay results were correlated with OS using univariate Kaplan-Meier, hazard function plots and multivariate Cox regression analyses. Clinical outcome data were drawn from medical chart review. Measurements of H2T and H2D were tested for association with OS, defined as the time from start of trastuzumab treatment to cancer-associated death or the end of the follow-up period. The median duration of patient follow-up period was 18.2 months. The median duration of trastuzumab treatment was 14.6 months. As a whole, 2-year survival rate of the cohort was 60.8% (95% CI: 48.4-73.2%). In the univariate analyses, patients were classified into 4 subgroups defined by the 25th, 50th, and 75th percentiles for each of the 3 variables, H2T, H2D, and their ratio H2D/ H2T. Hazard function plots were estimated in the 4 H2T subgroups, and the subgroups with the 25% highest and lowest H2T values had substantially lower risk of death than the middle 2 subgroups. Dividing the cohort into high HER2-expressing (≥the median value of H2T) and low HER2-expressing (<the median value of H2T) sub-groups and using the Cox regression analysis with the continuous H2T value in each of the 2 subgroups, those patients with higher values for HER2 expression lived longer than those with lower values for H2T in the high HER2- expressing group (HR: 0.06; p=0.010; 95% CI: 0.01-0.51). In contrast, in the low HER2-expressing group, the opposite trend (those with lower H2T values were favored) was observed (HR: 16.0; p=0.017; 95% CI: 1.64-155.9). The authors concluded that their data suggest that there are 2 subpopulations of patients in this cohort that behave differently with respect to HER2 expression and OS and that the quantitative amount of HER2 expression measured by HERmark may be a new useful marker to identify a more relevant target population for trastuzumab treatment in patients with metastatic breast cancer.
Lipton and colleagues used the HERmark assay to quantify HER2 expression and examined outcomes in 102 trastuzumab-treated metastatic breast cancer patients previously assessed as IHC 3+ by local but not central IHC, or FISH-positive, and then retested by central FISH. (8) Of 102 metastatic breast cancer patients previously scored as IHC 3+ or 2+/FISH-positive and treated with trastuzumab-containing regimens, 98 had both central FISH and HER2 total expression values. Sixty-six of 76 central FISH-positive patients (87%) had high HER2 total expression levels (concordant positive), and 19 of 22 central FISH-negative patients (86%) were HER2 total expression low (concordant negative). Fourteen percent (3 of 22) of central FISH-negative patients were HER2 total expression high (discordant HER2 total expression high), and 13% (10 of 76) of central FISH-positive patients were HER2 total expression low (discordant HER2 total expression low). The concordant positive group had a significantly longer time to progression (time-to-progression [TTP] median: 11.3 months) compared with the concordant negative group (median TTP: 4.5 months; HR: 0.42; p<0.001), and also compared with the discordant HER2 total expression low group (median TTP: 3.7 months; HR: 0.43; p=0.01). The discordant HER2 total expression low group behaved similarly compared with concordant negatives (HR: 1; p=0.99). In analyses restricted to central FISH-positive patients only (n=77), Cox proportional hazards multivariate regression identified HER2 total expression as an independent predictor of TTP (HR: 0.29; p=0.0015) and overall survival (HR=0.19, p<0.001). The authors concluded that a subset of patients with HER2 gene amplification by FISH express low levels of HER2 protein and have reduced response to trastuzumab-containing therapy, similar to FISH-negative.
Clinical utility
Data on the clinical utility of HERmark are lacking. Clinical trials are needed to understand the relationship between quantitative HER2 expression and homodimer measurements with clinical outcomes in breast cancer patients stratified by the HERmark assay being treated with anti-HER2 therapy in the adjuvant and metastatic settings.
Duchnowska and colleagues investigated the correlation between quantitative HER-2 expression in primary breast cancers and the time-to-brain metastasis (TTBM) in HER-2+ advanced breast cancer patients treated with trastuzumab. (9) The study group included 142 consecutive patients who were administered trastuzumab-based therapy for HER-2+ metastatic breast cancer. HER-2/neu gene copy number was quantified as the HER-2/centromeric probe for chromosome 17 (CEP17) ratio by central laboratory FISH. HER-2 protein was quantified as total HER-2 protein expression (H2T) by the HERmark® assay in formalin-fixed, paraffin-embedded tumor samples. HER-2 variables were correlated with clinical features and TTBM was measured from the initiation of trastuzumab-containing therapy. A higher H2T level (continuous variable) was correlated with shorter TTBM, whereas HER-2 amplification by FISH and a continuous HER-2/CEP17 ratio were not predictive (p =0.013, .28, and .25, respectively). In the subset of patients that was centrally determined by FISH to be HER-2+, an above-the-median H2T level was significantly associated with a shorter TTBM (hazard ratio, [HR]: 2.4; p=0.005), whereas this was not true for the median HER-2/CEP17 ratio by FISH (p=0.4). Correlation between a continuous H2T level and TTBM was confirmed on multivariate analysis (HR: 3.3; p=0.024). The authors concluded that their data revealed a strong relationship between the quantitative HER-2 protein expression level and the risk for brain relapse in HER-2+ advanced breast cancer patients and that quantitative assessment of HER-2 protein expression may inform and facilitate refinements in therapeutic treatment strategies for selected subpopulations of patients in this group.
Retrospective analyses using HERmark have shown that the assay may predict a worse response to trastuzumab in certain populations. The clinical utility of the HERmark assay has not been demonstrated, and clinical trials are needed to determine the impact on the clinical outcomes of patients stratified by the HERmark assay.
Practice Guidelines and Position Statements
National Comprehensive Cancer Network (NCCN) Guidelines on the treatment of breast cancer (v3.2012) do not address the use of HERmark. (10)
National Cancer Institute (NCI) Physician Query Database (PDQ) returned no trials using HERmark.
Disclaimer for coding information on Medical Policies
Procedure and diagnosis codes on Medical Policy documents are included only as a general reference tool for each policy. They may not be all-inclusive.
The presence or absence of procedure, service, supply, device or diagnosis codes in a Medical Policy document has no relevance for determination of benefit coverage for members or reimbursement for providers. Only the written coverage position in a medical policy should be used for such determinations.
Benefit coverage determinations based on written Medical Policy coverage positions must include review of the member's benefit contract or Summary Plan Description (SPD) for defined coverage vs. non-coverage, benefit exclusions, and benefit limitations such as dollar or duration caps.
Experimental, investigational and unproven for all diagnoses.


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Hydra, Greece Youth Hostels - Welcome to Botsis Guesthouse in Greece
Find a Hydra, Greece hostel and save money on discount lodging. Hosteling in Hydra, Greece offers a different travel experience than staying at traditional accommodations. Youth hostels allow you to meet new people and learn from other international and worldly travelers. Most hostels are conveniently located in the center of the action close to public transportation, including buses and rails. Staying at a Hydra, Greece hostel is a great option whether you are backpacking or traveling on a budget . Browse our hostels and plan your Hydra, Greece vacation today!


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You know, you've really got to hand it to the surgeon who performed Brooke Hogan's sex change surgery. That guy did a great job. I mean, in these Brooke Hogan bikini pictures, you can hardly tell that she used to be a man. A little nip here, a tuck there, breast implants, a shaved chin (I'm talking about the bone, not the hair), and the ultimate snip-snip, and there you have it: a post-op transexual almost capable of fooling us into believing he's a she. Oh the marvels of modern medicine.
Photo credit: INF Photo


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Yurei no Yurei – compilation Necktar 2017 vol 7 (free download)
January 23, 2015
A new track, Yurei no Yurei, is available in the 7th volume of Compilation Necktar 2007 whose theme is "Death / Transmission / Life : Mythos."
A lossless (flac) version is available for free download from soundcloud
Various Artists- Loop Messiah [treetrunk 317]
January 17, 2015
An interesting compilation featuring one track by Kecap Tuyul
Originally posted on Treetrunk Records:
Why pay tribute to Robin Storey's Rapoon? As a listener, Robin's music was immediately interesting to me, because drone music as a genre was something I hadn't yet heard. Soon, I became captivated by this conversation between sounds– samples interacting, some looped, others making unique or shorter appearances.
Technically, then, this was musique concrete– or largely that. It was also listenable– very "musical" in a traditional sense. Like with Zoviet France, Robin's Rapoon tracks pulsed along with the best of the minimalists. They also showed me that world sounds and "Western" sounds could interact, and that beats did not have to be mathematically regular.
In creating new songs, Rapoon broke a lot of rules I thought existed for music. But this was done in such a compelling and pleasing way. I was very fortunate to collaborate with Robin briefly in the early…
View original 182 more words
Ayato & Kecap Tuyul : Amnesic Pilgrims (Tapesafe, free download)
January 5, 2015
Amnesic Pilgrims is a new collaboration album released by netlabel Tape-Safe. Lots of acoustic guitars this time…
Kecap Tuyul : acoustic & electric guitars
With sounds from
– Oya Dante "Tete Monde" on track 9
– Brian Lewis Saunder "Razen-the confessor/Classwar Karaoke Friends-pickle all enemies" on track 10
Recorded in various places 2012-2014
Jeff Sampson & Kecap Tuyul : Nocturnes
May 12, 2014
"There is a charming satisfaction in successfully collaborating with someone over the Internet. Two people in different countries sharing ideas, critiquing in constructive ways, producing sounds brought out from hearing what the other has done – those are a few of the joys that come from working with someone who listens. Long distance improvisation in non-real time.
Kecap Tuyul and I spent a good amount of time working on, ultimately, four audio tracks. We were patient. We were willing to work until they were the best we could do.
We hope you are able to get some pleasure from listening to what we did together."
(Presentation text from Jeff Sampson, april 2014)
Crows in the Garden & Kecap Tuyul
March 25, 2014
The Road of Life, a collaboration track with Crows in the Garden has been released by treetrunk
A full album will be published later this year
Ayato & Kecap Tuyul : Ships in the sand (Alter Sonic Records)
February 15, 2014
New collaboration album with Ayato out on Alter Sonic Records
Available in different formats (free mp3, CD-R..). Click on the picture for more informations.
Restes (free download, Eg0cide Productions)
January 4, 2014
New solo album: Restes out on Eg0cide Productions. As often, it is based on improvisations on prepared guitar. But this time the raw material has been overdubbed later and gave birth to some kind of weird, foggy "songs" (?).
Click on the picture to visit the release page on archive.org
Download the full album (including artwork)
Xylophonium Algosis is Ayato & Kecap Tuyul's 4th collaboration album, and probably the weirdest to date – also maybe one of the weirdest albums published on eg0cide…
Click on the picture to visit the download page on archive.org
Eg0cide has just released 2 X 2 , a collection of 2 live duos featuring Kecap Tuyul on prepared guitar that were improvised and recorded in summer 2011 & 2012, with Charles premier and Matthew Tyas.
Charles premier is an electroacoustic composer and improviser. He builds his own instruments, and used them in a live context for the first time during this summer 2012 sessions (with the Elektranuss Orkhestra & Kecap Tuyul)
Matthew Tyas is a multimedia artist (composer/songwriter, multi-instrumentist, improviser, film-maker). On this recording he played his main instrument : piano (but prepared this time) and voice.
With special thanks to Philippe Petitpré (Mescalibur) who made these meetings happen.
Click on the picture to visit the download page on archive.org
Kecap Tuyul : my other shadow (Webbed Hand Records, free download)
September 8, 2012
My other shadow is a completely acoustic album, rather lo-fi and mostly improvised during a rainy week of april 2012 (although using also some old recordings from 2009-2010)
Special thanks to Kecap Tilil for having pushed me to record acoustic guitar, and to C.P. Mc Dill for the support and release on his netlabel Webbed Hand Records.
Click on the picture to visit the download page


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COMM GAMES SWIMMING: Australia's 4x100m freestyle relay team of Bronte Campbell, Melanie Schlanger, Emma McKeon and Cate Campbell have broken the world record
SWIMMING: The Australian Swim Team for the 2014 Commonwealth Games in Glasgow has been announced, tonight following a week of world class action at the Australian Swimming Championships in Brisbane.
SWIMMING: Queenslander Grant Irvine has announced himself on the Australian swimming scene by recording the second quickest Australian men's 200m butterfly of all time, at the 2013 Australian Swimming Championships in Adelaide tonight.
SWIMMING: In another bonding initiative following the London Olympics, the Australian swimming team will train alongside the country's rising stars at a six-day national camp on the Gold Coast next week.
SWIMMING: Alicia Coutts was rewarded for her standout performance at the London Olympics as she claimed her second Australian swimmer of the year award on Saturday night.
SWIMMING: London Olympic gold medallists Melanie Schlanger and Brittany Elmslie will headline a group of more than 450 athletes heading to Perth for the EnergyAustralia Short Course Championships next week, with swimmers vying for selection for the FINA World Championships in Turkey this December.
TEAM: Olympic gold medallists Cate Campbell and Melanie Schlanger and long jump silver medallist Mitchell Watt have reminded the media to focus on the achievements of the Australian Olympic Team rather than criticise their lack of gold medals in London.
SWIMMING: The Australian team of Bronte Barratt, Melanie Schlanger, Kylie Palmer and Alicia Coutts have put up a brave fight in the battle to defend their Olympic 4x200m freestyle relay title before going down to a white hot USA team.
SWIMMING: With the newly bestowed title of Olympic champion following her into the pool, Australian Melanie Schlanger has qualified second for the semi-finals of the women's 100 metres freestyle after this morning's heats.
SWIMMING: First night of finals at the London Aquatic Centre and Australia featured in all four finals and swam to a sensational gold in the final event of the session the women's 4x100m relay final.
© Australian Olympic Committee. All rights reserved. Website engineered by Daemon


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Search Tags: George Allen
GOP voting bills aimed at party hegemony in Va
Virginia's not the only electoral battleground with a Republican-ruled legislature where President Barack Obama mopped up last year en route to re-election. But it is the first to act on an ambitious menu of Republican legislation aimed at preventing another Democratic triumph.
Tags: Jamie Radtke , Virginia Senate
Virginia Senate candidate wants to pay feds for cost-cutting ideas
Former Virginia Governors George Allen and Tim Kaine offer contrasting ideas on issues affecting federal employees and contractors. In Maryland, former federal employee Dan Bongino is challenging incumbent Sen. Ben Cardin for his seat. Bongino and Cardin hold similar views on a number of employee issues.
Tags: management , Senate , Congress , Tim Kaine , Ben Cardin , Dan Bongino , Rob Sobhani , 2012 election , Jason Miller
Former Va. Gov. Allen early to pronounce conservative principles
Mark Plotkin, WTOP political analyst
Tags: Mark Plotkin , Virginia ,
Allen again voices regret for 'macaca' remark
Former U.S. Sen. George Allen is again saying that he regrets using the term "macaca" to refer to a Democratic campaign volunteer of Indian ancestry in 2006.
Tags: macaca , Jim Webb , Senate , election
Poll shows a dead heat for a possible Kaine, Allen matchup
An early poll shows former Virginia governors Tim Kaine and George Allen are in a dead heat in the U.S. Senate race to replace retiring Democratic Sen. Jim Webb.
Tags: poll , Senate , elections , Tim Kaine ,
Va. Senate race will be marquee national contest
Charlie Mahtesian, national politics editor for Politico
Tags: Charlie Mahtesian , Politico , U.S. Senate , Tim Kaine , Jim Webb , Debbie Wasserman Schultz
Corey Stewart not ruling out run for U.S. Senate
A decision by one local politician to seek re-election to his current job has surprised many and may affect a race for the U.S. Senate.
Tags: Corey Stewart , Prince William County Board of Supervisors , Prince William County , Jim Webb , U.S. Senate , Hank Silverberg
Va. Republicans look for challenger against Sen. Webb
Although no one has announced their candidacy yet, western Prince William Del. Bob Marshall (R-13th), former Gov. George Allen and Prince William County Board of Supervisors Chairman Corey Stewart are positioning themselves for a run.
Tags: Jim Webb , Senate , Bob Marshall , Corey Stewart
George Allen talks about prejudice
For years George Allen avoided questions about his Jewish background. Now he's talking about it.
Tags: Reston , National Jewish Retreat , Hyatt Regency Reston
BTA's Pair to retire; Marines Allen to be promoted
Maj. Gen. Carlos Pair is retiring from the Defense Department's Business Transformation Agency after 37 years of active service.
Tags: management , Carlos Pair , DoD , BTA , Marines


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Mon-Fri: 7am-1am EST / Sat-Sun: 7am-11pm EST
ApplianceWhirlpool Washer
Level of DifficultyEasy
Time to do repair15 - 30 mins
Age of Appliance5 - 10 years
PliersNutdriverScrew drivers
1 out of 1 people found this instruction helpful
I read the other posts that described how to do the repair. There was tell tale black rubber shavings around the drive and motor area. All you have to do is remove the retaining clips that hold the water pump, remove the hoses(make sure to drain in bucket ect.), remove the wiring harness taking care to leave the capacitor lead intact if the washer has been run in the last 24 hrs to prevent a shock. Remove the two clips holding the motor in place. Remove the four bolts holding the motor base. The coupling is attached to the motor, use a screwdriver ect. to gently pry off the coupling. The old one will likely be round, the new part will be triangular. Same thing. Fit the platic pieces (2) one to the motor and the other to the drive with the rubber in the middle fitting into the allotted holes in the rubber. Reverse the procedure to finish. I saw there was a slightly lower price on a competitors web site by maybe 2.00 dollars. I went with this site because I received help like this I am giving you and want to reward these people for their ingenuity of having this type of forum for others. Please do the same. Doug
Help other customers find the most helpful instructions.
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Part Number: PS1485646
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Skip to main content
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Top Resolutions for Business in 2006
A Small Business Television (SBTV.com) poll, of 600 owners of small businesses, reported that 70 percent would make marketing and sales their top business resolution, followed by technology at 26 percent, according to a Principal Financial Group. Only 2 percent of the respondents would make business finance-related resolutions, with the same number resolving to focus on workforce issues. Internet marketing is at the top of the "Six for '06" list of business resolutions developed by AllBusiness.com, a leading online resource.
Dec 26 2005
Company Drug Prescription Plans Vary
The Kaiser Family Foundation has released a new retiree health benefits survey showing that almost 80 percent of employers that currently offer retiree health benefits will take government subsidies to maintain prescription coverage in 2006. The Pittsburgh Post-Gazette reports that the basic Medicare coverage of more than 12 million retirees is supplemented by company health plans. The annual survey was released last week in Washington.
Dec 22 2005
Community News
AICPA Supports Bill on Non-Resident Retirement Income
The American Institute of CPAs has supported a House bill that would ensure that certain deferred compensation plans would not be eligible for non-resident state income tax.The AICPA said that it opposes the position that states can tax the nonqualified retirement benefits paid by a partnership to its retired non-resident partners.States are prohibited from taxing the retirement income of non-residents under Public Law 104-95, passed in 1996.
Dec 22 2005
FTC Fines DirecTV $5M for Privacy Violations
Signaling that the federal government is serious about enforcing the national Do-Not-Call Registry, the Federal Trade Commission has fined a satellite television operator more than $5 million.The FTC contends that DirecTV and companies it hired to promote its programming, have violated the do-not-call law since October 2003. The FTC announced the company would pay a $5.3 million fine.The do-not-call list has been lauded as a government success story, with 110.4 million residential and mobile telephone numbers registered, the Washington Post reported.
Dec 21 2005
European Parliament Passes New Accounting Rules
The European Parliament has passed strengthened accounting rules to increase transparency and to avoid some of the pitfalls of the Enron and Parmalat scandals. The Financial Times reports that companies in the European Union will have to disclose off-balance sheet arrangements and their financial impacts. Listed EU companies will be required to publish annual corporate governance statements, as well.
Dec 19 2005
Don't Let Holiday Time Be Scam Time
Santa and his elves are not the only busy people at this time of year. Robbers, thieves, carjackers and shoplifters all seem to thrive during the holiday season.
Dec 15 2005
Bill of Rights Day: Not Just Another December Holiday
Thursday, December 15, is Bill of Rights Day. On that day, back in 1791, the first ten amendments, the Bill of Rights, of the U.S. Constitution, were ratified by three-quarters of the original states.
Dec 14 2005
Retiree Drug Coverage; Competition Intense Among Medicare Insurers, Employers
Four in five employers that pay for retirees' drug costs will accept government subsidies to continue coverage, according to a survey conducted by the Kaiser Family Foundation and Hewitt Associates, of 300 companies with 1,000 employees each, the Seattle Post-Intelligencer reports. When it drafted the program, Congress created a tax-free subsidy to encourage companies to continue offering retiree drug coverage. The subsidy, for 2006, will be equal to 28 percent of a retiree's drug costs between $250 and $5,000, the Intelligencer states.
Dec 14 2005
Community News
Regulators Call for More Transparency, Less Complexity
The Securities and Exchange Commission (SEC) is seeking help from the accounting industry to simplify the rules that may be partly to blame for the corporate scandals of recent years, the SEC chairman said Monday.The SEC, working with the Public Company Accounting Oversight Board (PCAOB) and the Financial Accounting Standards Board (FASB), is undergoing a "major national effort to make accounting less complex," said SEC Chairman Christopher Cox, at the American Institute of Certified Public Accountants' (AICPA) annual meeting in Washington, D.C.
Dec 12 2005
President, Congress Turn to Immigration Reform
President Bush delivered a major speech last week outlining his plan for immigration reform, bringing into focus, once again, Americans' troubled relationship with undocumented workers, the Hudson County Journal News reports. The House and Senate are considering four other separate proposals.Estimates of the number of illegal immigrants in the U.S. today range from 8.7 million (U.S. Census Bureau) to 20 million (Bear Stearns, the investment company), according to Reuters.
Dec 9 2005
SEC Eases Revenue Accounting Rule for Vaccine Makers
The Securities and Exchange Commission (SEC), on Monday, announced a change in accounting guidance for pharmaceutical companies supplying vaccines to the Pediatric Vaccine Stockpile or the Strategic National Stockpile. Under the new guidance, vaccine manufacturers can recognize revenue upon delivery to government stockpiles rather than delaying revenue recognition until the vaccine is distributed.
Dec 8 2005
Tax Reform May Wait Until 2007
A rewrite of the tax code, once targeted as a major theme for 2006, may be pushed back by one or two years.A tax proposal is unlikely to draw Democratic support in a mid-term election year, according to Time magazine, quoting anonymous Republican sources. "No one wants to put something out there that's not going to go anywhere," a White House official told the magazine.
Dec 7 2005
Community News
New Jersey Task Force Releases Plan for Underfunded Pension System
New Jersey's pension system needs $12.1 billion to meet its current pension obligations to teachers, police officers and local government workers, according to the report of the governor's Benefits Review Task Force released last week.The Task Force, appointed by Acting Governor Richard Codey and headed by retired Goldman Sachs executive, Philip Murphy, concluded that the current system could not be maintained without large tax increases or severe cuts in state services, Bloomberg.com reports.
Dec 7 2005
Microsoft Yields: Will Adopt Open Document Formats
In an apparent effort to respond to Massachusetts' Governor Mitt Romney's plan to adopt a so-called OpenDocument format for storing state documents by 2007, a move that could eventually cause the state to remove Microsoft's Office software from its computers, Microsoft announced in November that it would submit its Office Open XML (XML) to the standards body Ecma International, at their December meeting, the Associated Press (AP) reports.
Dec 6 2005
2006 PCAOB Budget Approved
The Public Company Accounting Oversight Board (PCAOB) has approved its 2006 budget of $128 million. The accounting industry regulatory agency will use a $19 million excess from a 2005 budget to reduce the 2006 accounting support fee paid by publicly traded companies according to Reuters. Accounting support fee assessments of $109.3 million are projected for 2006 while $136.1 million in fees were assessed in 2005 according to the Compliance Reporter. The approved budget has been passed onto the Securities and Exchange Commission (SEC) for final approval according to Reuters.
Dec 5 2005
Hawaii Bottle Bill Fails Audit
After two years of preparation by Hawaii's Department of Health (HDOH), the State's Deposit Beverage Container Program or so-called "bottle bill" has become an accounting nightmare according to the state auditor's report. There have been $39 million in collections as of June 2005 and HDOH still lacks an auditable financial accounting system.
Dec 2 2005
Practice Management
Governance & Accounting Still Concern Investors
Things have improved but there is still cause for concern. That is the message investors and creditors seem to be sending in a special report published Monday by Standard and Poor's."Governance and accounting remain heightened areas of concern for investors and creditors, and it remains critically important for them to assess the often qualitative, intangible, and principle-based dimensions of governance and accounting," said George Dallas, managing director and global practice leader, corporate governance, Standard and Poor's in a prepared statement.
Nov 30 2005
Community News
Job Losses in Cities Mounting But Accounting Firms Prosper
Federal programs sponsored by both the Clinton and Bush administrations over a period of years have failed to stop the loss of jobs in the nation's cities, according to a Harvard University study reported by the Associated Press. Nearly half of the country's 82 largest municipalities lost jobs from 1995 to 2003 in comparison with surrounding metropolitan areas, only one of which lost jobs.Michael Porter, the Harvard business professor who conducted the study said "It's sobering. . . .
Nov 29 2005
State Surpluses May Lead To Tax Cuts
The U.S Bureau of Economic Analysis reports that state and local revenues are up 7.2 percent in the first three quarters of 2005. With state personal and corporate tax collections peaking, the question is what to do with their revenue surpluses in 2006. Strong revenue growth has New Mexico realizing a $1 billion surplus, Florida a $3 billion, and even California seeing a $3.4 billion surplus according to USA Today. States taxing energy production and real estate construction have seen windfalls also. "Every month we're surprised by the good news and say it has to slow down.
Nov 22 2005
Senate Pension Reform Bill Approved
The Senate passed a bill aimed to strengthen U.S. company pension plans although warned that President Bush intends to veto the legislation. The White House labeled the bill inadequate according to the New York Times. The House may reconcile two bills that were approved by separate committees next month.In a prepared statement, Bill Thomas, Chairman of the House Ways and Means Committee said, "Pensions obviously are a critical component of retirement security for millions of Americans, providing an important source of income for retirees.
Nov 22 2005
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Unmotherly Insights - Lunch Time Theater
Gaden Shartse Monks Sand Mandala Creation
Illuminate Film Festival
Memorial Day Sidewalk Sale
Stop in and shop for fantastic deals all weekend long, May 22-25, 2015
Kartchner Caverns: One of the Great Wonders of the World!
Enjoy round trip transportation from Sierra Vista to experience a stunning limestone cave that boasts world-class features.
Red Rock to Alpine Meadows Guided Motorcycle Tour
2 Days / 1 Night Guided Tour Price includes hotel.
It's hard to imagine the natural beauty and diversity offered by the state of Arizona without experiencing it yourself. This tour allows exactly that; one that extends from the saguaro and ocotillo cacti of the Sonora desert to the unique red rocks of Sedona, Arizona, and then climbing to alpine meadows with the cool pine-fragranced air found at 8000+ feet elevation. Spend an evening enjoying an optional group dinner and visiting lively and quaint downtown Flagstaff, Arizona. It doesn't stop there, after a refreshing night's sleep the tour continues with unmatched scenery as you traverse down from elevation, stopping to visit sheer canyon drops of hundreds of feet, riding next to oak-lined creeks, and sweeping through open sections of big-sky country. There might even be a home-made ice cream stop or two along the way just to sweeten the deal!
Price: $499
9431 E. Coralbell Ave.
Lot 109
Mesa, Arizona
RestrictionsThe entire route is on asphalt. A good portion of the route runs on very narrow, sometimes single lane roads. The roads are very curvy with quite a few tight switchbacks. Some riding days are quite long and demanding. Traffic may be very intense and unusual at times, with local driving habits that differ significantly from what you are used to. You must be a VERY experienced rider to take part in the tour. A minimum of 10,000 miles of motorcycle experience is required to participate, and you must ride motorcycles on a regular basis at home.
Offer Valid:
Jun 28, 2014 — Jun 29, 2014
9431 E. Coralbell Ave.
Lot 109
Mesa Arizona
Phone: 602.677.7853
Email: email@example.com
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An old fashioned teleport sound, created with a tone generator, that reminds me of the sci-fi tv shows of the 70's.
I used it with a 60 frames fadeout, but I uploaded it in the "unprocessed version" to leave you more room to customize it.
Maybe I'll add it!
There's no BOOM after that?!?
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A Recommendation For Shoppers
Saturday is Super Saturday. It's not the day for the biggest deals but it the day for the most purchased made. Shoppers definitely need to check out this site.
Saturday is Super Saturday. It's not the day for the biggest deals but it the day for the most purchased made. Shoppers definitely need to check out this site.
MIX 106 was out at Robert Comstock at The Village with Mike Kasper today bringing you some holiday savings! Robert Comstock is a very well know designer and is actually an Idaho native! His clothing designs are very well known and we are lucky to have his only store in the entire world
Could you imagine getting lingerie from a co-worker? Surprise!
Maybe this has happened to you too this weekend. You're in an actual store, holding a hot Christmas item in your hands, and you think, "Eh, I can probably find it cheaper online."
Shopping is good for us and necessary for our peace of mind. Anyone who wants to argue that point (eh hem...my husband), here are reasons why we NEED to shop.
Hows the Black Friday shopping going? I love saving money, and I use coupons on almost everything. If it's not on sale or I don't have an extra 20 percent off coupon, I don't buy it. Unless it's coffee. Gotta have that at all costs. I've already messed up this money-saving adventure called Black Friday, and here's how.
We know this already. Not all Black Friday sales are great deals.
But how can we tell?
Some stores are opening up at 5 or 6pm on Thanksgiving Day to help you burn some calories after all the turkey and cranberries. But others have said no, and won't open up until Black Friday. Check out the growing list of stores that WON'T open on Thanksgiving Day.
As you're meandering through the clothing store, do you notice if the mannequin is making eye contact with you? I do! Just try to escape that gaze. It's impossible.
I sat my three girls on the couch on Sunday and had them point to things they wanted in a Christmas catalog, and they found something they were dying to have on every single page. Not my brightest parenting move! Now I have a list of 40 things on their wish list and still no clear idea of what to get.
I'll pick up a few things here and there ahead of Thanksgiving, but I'm planning to keep Thanksgiving Day all about food and family. No shopping. Anyone with me? I heard people talking yesterday about one family that's not having Thanksgiving dinner on Thursday the 27th so they can hit sales at the stores instead. OMG.


text: 7300 Flagship Park Northshore On Lake Travis Ph 01, Jonestown, TX 78645 Status: Off Market MLS#: 2267261 Contact Email this listing Share on Pinterest Share on Google+ Share on Facebook Share on Twitter Calculate Mortgage Print Flyer Get Directions Request a Showing Off Market 7300 Flagship Park Jonestown, TX 78645 is no longer on the market or has been removed from the MLS. Similar to 7300 Flagship Park : Ask an Agent About 7300 Flagship Park * Required fields Send Your Question × Monthly Payment Estimator Price: Down Payment: % Loan Amount: Loan Type: 30 Year Fixed 15 Year Fixed 5/1 ARM Interest Rate: % Est. Tax & Insurance: % ($/mo.) Est. Monthly Payment: $478 per month × Email a Listing 7300 Flagship Park, Jonestown TX, 78645 From: Name: Email: To: Name: Email: Subject: Message: Take a look at this property I found on AustinTexasResidence.com: http://www.austintexasresidence.com/homes/7300-Flagship-Park/Jonestown/TX/78645/12358923/ Send a copy of this message to me Send Email


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David Silverberg, editor, Homeland Security Today
Click to hear the interview
Jump to main content.
Monday - 4/19/2010, 4:01pm EDT
Click to hear the interview
Today marks the 15th anniversary of the event that sparked the creation of the Federal Protective Service; the bombing of the Alfred P. Murrah Building in Oklahoma City.
Now, the agency charged with the security of federal civilian buildings might see its workforce wholly, or partially, federalized this year as Congress drafts legislation to do that, while the Department of Homeland Security is conducting a separate review.
Homeland Security Today editor David Silverberg brings us analysis of what this change could mean.


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The Newton County Board of Education (BOE) approved of a tentative budget for the 2015-2016 school year during its Tuesday night work session.
Newton County school officials discussed four possible budget scenarios for the next school year that could cease any furlough days, increase the amount of money paid to the Teacher Retirement System (TRS) and raise for all employees' salaries in the Newton County School System (NCSS).
What your growing child needs from you, right now.
Page 1 of 1
For any parents wondering how their kids will spend their summer, a new opportunity just popped up, and Thursday, May 1 is the only day to get your name down.
Newton County is home to the best scoring middle school in the state in 2013, according to the College and Career Ready Performance Index (CCRPI) the Georgia Department of Education released earlier this week.
The Newton County Board of Education unanimously approved Superintendent Samantha Fuhrey's recommendation from the April 15 work session to renew its contract with Ombudsman Educational Services, Newton's alternative and special education and behavioral therapy program, during the April 22 meeting.
When children read their favorite childhood books, they may often imagine what those stories would look like if they popped out of the book in front of them.
Newton High School officially has a new head honcho, and everyone wanted their turn to tell John Ellenberg congratulations.
It's the school's turn to get graded.
Teachers, students and faculty in Newton County schools will soon be safer from potential carbon monoxide leaks at a cost of thousands of dollars cheaper than originally expected.
Officials with Ombudsman Education Services, the Newton County School System's alternative education provider for at-risk students, made their pitch to get their contract renewed for the next year, and potentially next three years.
Georgia Perimeter College is one of 27 University System of Georgia institutions that will see only a 2.5 percent increase in tuition for the 2014-2015 academic year, a smaller percentage than average increases throughout the state.
The Georgia Criterion-Referenced Competency Tests will be administered to all students in grades three through eight April 22-May 1.
Choirs from two Newton County schools traveled over 400 miles to perform at the Walt Disney World Resort in Orlando, Fla., becoming the stars of their own Disney show on April 5.
Officials with Ombudsman Education Services, the Newton County School System's alternative education provider for at-risk students, made their pitch to get their contract renewed for the next year, and potentially next three years.
The Newton County School System announced a day for parents and community members to come together to participate in education workshops aimed at increasing student success in the classroom.
Only two high-schoolers in Newton County made the cut to participate in the Georgia All State Chorus, and they are both Eastside High students.
Seven Newton County students were recently selected to participate in the State of Georgia All State Bands, according to a press release from NCSS.
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Socbay iMedia is a multimedia application of entertainment for mobile which is developed on the search technology platform of Socbay. The software impressed users by intelligent technologies- Fast speed, friendly and easy to use interface, up-to-minute news updating, exact and various search result, fluent Mp3, video streaming, image viewing and dowloading, memory optimize to suitable for each mobile. At the moment, SocbayImedia is supplying 13 services- News.
Display your input letter like a LED scroller and You can decorate beautifully your font and background. Also Easy to Catch a taxi, Concert cheer, Confession. Express freely all of your thinking. This is an application that display your input letter like a LED signboard. You can apply various Color, pattern and effect. Through mini-LED in my palm Please express freely. Therefore this is an useful application.
KRONEHIT We are most music.Austrias leading private radio station with over 2 million weekly listeners now on your Nokia device.Supporteddevices:5800XpressMusic,N97,N97 Mini,X6,5230.The application is powered by spodtronic.Download Collection.com periodically updates software information of KRONEHIT Touch Edition from the publisher spodtronic, so some information may be slightly out of date. You should confirm all information before relying on it.
worldcuptwitts allows your to search for twitts about the Football World Cup via Twitter people's messages. It display news about Football World Cup , players and teams, posted on the Twitter social network. You will get the latest and most interesting Football World Cup news. It will also display ads based on keywords , device and location.
This app gives you accurate friend's statistics for gender, age, relationship and location. Search friends using multiple criteria's. It is now very easy to find for instance, single girls or boys close to your age and your location. Create a list of your favourite friends. See the profile information and as well as photos of your friends and share it. Key App Features: - get accurate friends statistics for: gender, age, relationship and location; more to come soon! - search friends using
Lie Detector app are supposed to detect stress that is often present when someone tells you a lie and fears being caught. If you are not stressed, then it will detect nothing. Therefore, it would be counter-productive to use it on yourself as a lie-detector. Perhaps using it on someone else would be a better idea. This is not a real lie detector app.
The ultimate Free 8 step Weight Loss Guide to safe and effective Weight Loss. After extensive research. We have put together the ultimate 8 steps to Weight Loss guide you will ever need. NEVER leave home without it. Now you wont have to as its in the palm of your hands. This is not a quick diet handguide, but a change of lifestyle handbook. Follow these rules & you will not only lower your body fat & gain muscle, but live a healthier life. This was out together by some of the top nutritionists.


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Nevadans seek injunction on state's petition rules
October 14
CARSON CITY, Nevada: This week a 12-page lawsuit was filed with the U.S. District Court in Las Vegas seeking an injunction on Nevada's current initiative and petition rules. The lawsuit was filed by Sharron Angle, U.S. Senate candidate and former assemblywoman, and two ballot advocacy groups.[1] Specifically the lawsuit seeks to halt initiative laws approved by the Nevada Legislature in 2007, which they argue to be "unconstitutional and invalid." The 2007 approved legislation requires that petition gatherers sign affidavits under penalty of perjury in order to help better verify the validity of collected signatures.[2] The new law, said Angle, has made it difficult to qualify two initiatives for the ballot. According to the filed suit, "There are no reasonable, practical or economical ways for a circulator to know, while gathering signatures in the field, whether or not, a person signing the initiative petition is in fact a registered voter in that county."[1]
See also


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Autonomous Vehicles
Explorers have mapped the surface of the iconic Matterhorn painstakingly by foot, by satellite, and now by drone, thanks to a partnership between drone maker senseFly and nonprofit Drone Adventures. Launching a small squadron of eBee minidrones off the summit and sides of the famous Alps mountaintop, the mission tested the navigational abilities of the system and created a staggering data-rich 3D model. Read More
Robots compete in mock disaster-response scenarios at Eurathlon
September 26, 2013
Roboticists are competing in Europe this week to prove their superiority at bomb disposal and other dangerous tasks, but the teams are not comprised of military or emergency response personnel. Instead, unmanned autonomous vehicles and their human operators have gathered in Berchtesgaden, Germany at the first ever Eurathlon, a competition and convention designed to push innovation in smart robots that perform tasks that are too risky for humans. Read More
Cadillac SRX converted into a self-driving car
September 8, 2013
Self-driving cars have been the talk of the automotive industry in recent times, with some major car-makers now setting dates for the debut of these vehicles in the marketplace. The latest glimpse into this autonomous future comes from Carnegie Mellon University, where researchers have loaded a Cadillac SRX with an array of sensors that allow it to manage highway traffic, congested roadways, and even merging on and off ramps. Read More
Yesterday, Nissan's "Taxi of Tomorrow" officially became "today." Not wasting any time to look a little further into the future, Nissan has detailed some of its progress toward building cars that drive themselves. It says that the first batch of autonomous vehicles will be ready for market by 2020, and instead of just launching a single self-driving model, it plans to add the technology to several. Read More
Singapore to try out driverless shuttle on public roads
By Ben Coxworth
August 16, 2013
Should you be at Singapore's Nanyang Technological University (NTU) sometime soon, and wish to take the shuttle bus to JTC Corporation's CleanTech Park, you might find yourself in a vehicle that drives itself. Plans call for just such an autonomous shuttle to start running the 2-km (1.2-mile) route, as a real-world test of driverless public transportation. Read More
The cyber security convention DefCon and its corporate counterpart, Black Hat, that are held annually in Las Vegas present a unique tableau where the traditional (and traditionally overstated) conflict between underground hacking culture and corporate and government security professionals is suspended with the goal of openness and education. If you enjoy and own technology and gadgets of any kind, the conferences highlight a looming security crossroads that affects every layperson. Gizmag takes a look at some of the more important hacks from this year. Read More
Autonomous cars will be tested on UK roads before the end of the year, according to a government policy paper published on Tuesday. According to the BBC, trials will take place on less busy rural and suburban roads, using what the paper describes as a semi-autonomous mode which will allow a driver to take control of the vehicle if necessary. A driver will ride along during all tests for safety reasons. Read More
Name a toy car that follows lines while navigating. A hundred years ago you would've answered slot cars, which use a physical line. Twenty years ago saw the mass production of toys that use optical sensors to navigate a printed line. This generation's new racing wonder toy, Anki Drive, still uses optical sensors to navigate an invisible line, but can adopt numerous racing strategies, detect other cars and conditions on the track, and react instantly. While nominally the successor in the toy race car market, Anki Drive arguably has more in common with a Google driverless car than it does with its scaled toy counterparts, and Anki has grander ambitions in the field of autonomous robotics. Read More
Vehicle-to-vehicle communications are a fundamental pillar of autonomous, self-driving cars. Once vehicles can exchange data with each other and the greater driving infrastructure, they'll be able to "see" and adapt to driving obstacles more completely, preventing accidents and delivering more efficient driving. Mercedes plans to be the first automaker to bring a Car-to-X vehicle-to-vehicle communications system to market. Read More
Robots take a pounding for Ford test drivers
By David Szondy
June 16, 2013
Self-driving cars seem like they'll be on our roads any day now, but what about self-testing cars that can drive themselves around insanely destructive tracks? Engineers at Ford's Michigan Proving Grounds in Romeo, Michigan, say that they've come up with the industry's first robotic test system designed to drive trucks and vans over roads that are intended to put a decade of wear on a van in around three months. Read More


text:
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text:
Conker: Live & Reloaded
why has this suddenly become valuable? It blows
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It's just a prettier version of the original game...which wasn't even very good.
I dunno man. I liked it.
Because people realized that even though it got mixed reviews, its Conkers Bad Fur Day (one of if not the best looking N64 games, and one of the best overall games for the system) with super good graphics. And it's Conkers Bad Fur Day + more multiplayer, and also because people have most likely relaized Rare hasn't made a good new game this generation.
Subordinate terror,Kickin' off an era
but if you think this is becoming valuable you should do research on Jet Set Radio Future. It's near impossible to find the stand alone version of that game for a decent price.
Subordinate terror,Kickin' off an era
To the OP Oh, you're a real charmer.
Lindsey Buckingham's voice is like the cherry on top of an ice cream sundae. Fantastic!
Also - http://www.youtube.com/watch?v=QDVGCgklN3o&translated=1
^ Love the reference :D
[This message was deleted at the request of a moderator or administrator]
It was the multiplayer that kept everyone on.
>It's just a prettier version of the original game...which wasn't even very good.
What wasn't very good? If you mean this version then yes and no, it's a not very good version of the original. But the original game was very could, and had a far far better multiplayer than this version.
When you've finished here, don't forget to visit:
My main problem with the multiplayer is the explosive weapons have blast radius that are way too big and do too much damage.
If you thought the blast radius was big with the hand grenades in Halo 1, the grenades in this have a blast of 8-10 meters and the sneaker class snooper drone has a blast radius of 20 meters or more.
XBC: hobo_joe44 Xlink: hobojoe44
http://www.encyde.se : XBC/Xlink gamers group.


text:
- Filed Under
With a 7-inch height advantage over Fairdale's tallest starter, Trinity High School junior Raymond Spalding feasted in the paint Saturday night.
The 6-foot-9 Spalding posted 20 points, 17 rebounds and six blocks as the Shamrocks beat host Fairdale 77-67 in a quarterfinal of the Forcht Bank King of the Bluegrass Holiday Classic.
It's not uncommon for Spalding to have a size advantage, but he towered over a Bulldogs team that started 6-2 senior Terik Mason at center. The Shamrocks won the rebounding battle 45-30 and converted 17 offensive rebounds into 24 second-chance points. ...


text:
Originally written on Fox Sports Detroit | Last updated 11/14/14
Detroit Lions receiver Calvin Johnson issued a statement through the team Friday afternoon, retracting his previous stand that he sustained a concussion earlier in the season and also had recently suffered from nerve damage. "I would like to clarify some of my comments from yesterday," Johnson said. "I am aware that I did not suffer a concussion in our game against the Vikings earlier this year. I misused the terms 'nerve damage' and 'concussion.' "I have not suffered any nerve damage nor have I received any treatment for nerve damage. I did suffer a stinger and have also experienced the kind of wear and tear that most NFL players are dealing with at this point in the season." Coach Jim Schwartz vehemently insisted all along that tests by doctors during and after the Sept. 30 game against Minnesota showed that Johnson was not concussed following a hit to the helmet by Vikings linebacker Chad Greenway. The Lions also released a statement Friday on the issue: "With respect to the ...
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Important. The audio file for this mix is currently unavailable. Please try again later.
Audio Mainline Ent
kashif,Melba Moore,Patrice Rushen,The Wispers,Michael jackson,Evelyn Chamapgne King,Midnight Star,Cameo,New Edition,Maryjane Girls,One Way,Rick JamesThe Gap Band,Laid Back,
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- mitchelltom2000June 2011
good mix
- Audio Mainline EntJune 2011
thanks vol2 comin soon.
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I like thanx
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great mix looking forward to vol 2.3.4.
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Like the flow


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Andre Agassi prep school allegation of racism
View Single Post
Hall Of Fame
Join Date: Mar 2010
Posts: 1,968
No, that was an uprising...pretty much like what you saw in South Central. Those people there are tired of being f'ked over and that is just the end result of a corrupt system. Can you imagine really what it would be like here for White people to out number blacks but Blacks be in control of everything and in all the decision making positions for the last 200 plus years? Sooner or later something is bound to jump off.
I will say this. If Blacks were in control the same as whites have been, I don't see anything that would stop them from doing many of the same things to whites as whites have done to blacks through the years. The question right at this moment though is this. Do Blacks have the power in this country to to do whites what whites have done to blacks. The answer is clearly no. So the question of can Blacks be racist in "this" country? I say no. If they were given the same power would they be? I don't see anything that would lead me to bellieve that Blacks wouldn't be racist. That's why you need diversity.
Originally Posted by
That is exactly what has happened in South Africa and Zimbabwe.
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Posted June 30, 2003
This is the best book I have ever read! It has helped me to get so much closer to God. It has also helped me see how much God loves all of us and what he was willing to do for us.
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You are in a relationship with the love of your life! You and said love are happy as can be and [[FamousLastWords nothing can go wrong]]!
[[TemptingFate Then it does]].
And you hate the world. Especially since the world seems to be mocking you for it. As you walk through the park, EVERYONE is paired up. You see couples on the benches, making out, couples on the lake, making out, couples under trees, [[RuleOfThree making out]], even the birds and frogs and PLANTS seem to be paired up with their life-long partner, and you're not. The world is mocking you.
If this is a musical, then this scene usually involves a very sad song. In a romantic comedy, the scene may go to extreme lengths to show the pair ups, and the scene will come after the SecondActBreakup and before the reconciliation.
This trope can be PlayedForLaughs or PlayedForDrama. Also, it doesn't have to be about romantic breakups - it can also be used when someone has died or gone missing, or some highly emotional object has been lost through no fault of their own. In these instances, expect the protagonist to mistake other people or objects for the one they lost.
Look for LonelyPianoPiece in visual examples.
The romantic version is a subtrope of AloneAmongTheCouples.
Somewhat TruthInTelevision in that those who have recently lost something will tend to notice these things a LOT more than someone who hasn't suffered such a loss.
Compare ColdTurkeysEverywhere, wherein that trope is for people who willingly gave up something, and the world is tempting them constantly. Compare/Contrast SpontaneousChoreography. Contrast YouAreNotAlone.
[[folder: Anime and Manga ]]
* ''[[Manga/MidoriNoHibi Midori no Hibi]]'' does this to Seiji several times in both the anime and manga versions:
** In the first chapter of the manga, he becomes depressed after striking out with a local girl, only to find himself surrounded by lovey-dovey couples on his way to school... [[http://manga.animea.net/midori-no-hibi-chapter-1-page-6.html he doesn't take it well.]]
** And, in chapter 17, he ends up alone in [[http://manga.animea.net/midori-no-hibi-chapter-17-page-6.html a cafe full of happy couples.]]
** The anime version has him strike out with the same girl from the first example, after which, he goes to a movie theater to sulk. When he realizes he's the only one there without a date, [[Funny/MidoriNoHibi he vents his frustration on the crowd]] and storms out.
[[folder: Comic Books ]]
* When the eponymous ''GrooTheWanderer'' thought his dog Rufferto was dead [[spoiler:and that Groo had eaten him]] he kept seeing objects that reminded him of Rufferto's coloring.
[[folder: Literature ]]
* In ''[[Literature/ThursdayNext Lost In a Good Book]]'', Thursday starts seeing infants everywhere en route to her physician's office; she fears she's lost her pregnancy when she realizes Landen has been eradicated.
[[folder: Live-Action TV ]]
* In an episode of ''LizzieMcguire'', all of the protagonists are single, but that doesn't stop them noticing that all of their classmates aren't.
-->'''Gordo:''' Everybody's paired up...it's like Noah's ark.
* Played for ''extremely'' cruel comedy on ''Series/MadMen''. In the first season's [[WhamEpisode finale]] it was revealed that [[spoiler: Peggy had gotten pregnant out of wedlock with a married co-worker's baby; during the interval, she's apparently been ''legally declared'' unfit to raise the child, who's been put up for adoption (TheFifties were really a wonderful decade in which to be a woman). If you were to take a drink for every time babies, pregnancy, or abortion have been mentioned in her presence over the following three episodes, you'd end up needing your stomach pumped.]]
[[folder: Film ]]
* In ''Film/BetterOffDead'', Lane is constantly reminded of his ex, Beth, because every other guy in town (and [[WesternAnimation/TheFlintstones Barney Rubble]]) wants to date her.
* After Pat gets fired from the post office in ''It's Pat'', [[AmbiguousGender they]] get taunted by a little girl and her mother holding a briefcase, a magazine at a newsstand with a headline about unemployment, construction workers on break, firefighters and police officers greeting each other, and a pair of astronauts floating by.
* The "Scotty Doesn't Know" song in ''EuroTrip''. The song was written to brag about how Scotty's girlfriend was cheating on him with the singer. [[KickTheDog They break the news to him by performing it at his graduation party]], after which the song becomes a smash hit, RunningGag, and given the name of this film, a literal example of the world mocking his loss.
[[folder: Video Games ]]
* In ''VideoGame/FinalFantasyVI'', Celes is this trope embodied for Locke.
* A large source of angst for [[JerkassWoobie Ragna the Bloodedge]] from ''VideoGame/{{Blazblue}}'': he can't go far without coming across clones of his kidnapped and missing sister.
* PlayedForLaughs in the ''{{DJ Max}}'' series, where realizing The World Mocks Their Losses is the StartOfDarkness for the [=NB=] Rangers. A group of single, unlucky average joes transform into a {{Jerkass}} SuperSentai parody once they get fed up seeing other happy couples in the park and proceed to [[AntiLoveSong attempt to ruin them or just plain beat them up]].
[[folder: Western Animation ]]
* In ''Disney/TheLionKing'': Simba's Pride, the scene after Kovu gets exiled is this, complete with song "Love Will Find a Way".
* ''TheSimpsons'', after Ned lost his wife he sees couples dancing and having fun at the [[FictionalHoliday Jellyfish Festival]].
-->Marge: Poor Ned. This is his first Jellyfish Festival alone.
-->Homer: I know. And it doesn't get any easier from here. There's the Tongue-Kissing Festival, Cinco de Ocho, the Hobo Oscars, days just made for lovers. Not widowers... lovers.
** In the episode with Homer buying a handgun, he is dismayed when he learns that the registration process will take a few days. He spends those days moping on his lawn. A montage of tempting targets pass by during those days: a line of ducks, a Target truck, Patty and Selma on a bike...
* [[ParodiedTrope Parodied]] in the ''{{WesternAnimation/Futurama}}'' [=DVD=] Movie "The Beast with a Billion Backs"; right after Colleen and Fry break up, Fry sees increasingly [[CrackPairing comically unlikely coupling scenarios]].
* These are more "The World Mocks Your Discomfort", but in ''WesternAnimation/FamilyGuy'':
** In "The Son Also Draws" Peter's bowel is acting up during a long road trip. Every billboard and sign remind him of it (examples include "Furniture Store; all stools must go!"; "I Love My Shi-Tzu"; "Bob's House of Feces, Next Exit" [to which Peter responds "[[LampshadeHanging Oh come on, that one's not even real!]]"]).
** In yet another episode, Peter gets a prostate exam, and thinks he was violated. He tries to watch TV; he sees ''Film/FreddyGotFingered'', changes the channel to ''Film/ETTheExtraTerrestrial'', showing E.T.'s [[HealingHands healing finger]], then changes the channel to a Yellow Pages ad: "Let your fingers do the walking!" Peter then runs away and meets Chris wearing a foam finger, and the Evil Monkey who always points at people.
[[folder: Real Life ]]
* People who have often lost someone dear to them, by death or otherwise, will often be reminded of it constantly, if nothing else because of a natural inclination towards nostalgia, and [[EpilepticTrees reading into things]] that remind them of that person. Talking to someone who just lost someone through death can lead to some especially strange metaphors. The truth is, of course, they're constantly thinking about their loss, so it's not that everything reminds them, it's that they insert the lost person into everything else: "My mother bought me this game," "My wife and I saw this movie together," which they may not remember ''every'' time they boot up that game or watch that movie. Even going into predictions like "My brother would've loved this song." becomes common for grievers.
* It goes without saying on this site that friends, family and romance are HUGE parts of fiction. It's virtually impossible for a lonely person to peruse fiction of any kind without being subjected to this. The HaremGenre anime that you find hilarious could be torture to the romantically unlucky.


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