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An implantable cell/tissue-based biosensor device detects and/or monitors the amount of one or more specific analytes within a patient. Stimulation circuitry stimulates the cells/tissue of the biosensor device causing the cells/tissue to evoke a response that is altered by the presence of a specific analyte. Sensing circuitry detects the evoked response and the amount of analyte is determined based on the detected response.
1. A biosensor device for sensing an analyte in a patient, the biosensor device comprising:
a biosensing recognition element capable of interacting with the analyte and carrying out a response to electrical stimulation that is alterable upon interaction with the analyte;
an electrical interface contacting the biosensing recognition element;
stimulation circuitry, associated with the electrical interface, for delivering the electrical stimulation to the biosensing recognition element; and
sensing circuitry, associated with the electrical interface, for sensing the response of the biosensing recognition element to the electrical stimulation.
2. The biosensor device of
a biologic agent; and
a permeable membrane encapsulating the biologic agent.
3. The biosensor device of
4. The biosensor device of
5. The biosensor device of
6. The biosensor device of
7. The biosensor device of
8. The biosensor device of
telemetry circuitry in communication with the sensing circuitry.
9. The biosensor device of
10. An implantable biosensor device for sensing a plurality of analytes, the implantable biosensor device comprising:
a plurality of biosensing recognition elements, each biosensing recognition element capable of interacting with at least one of the plurality of analytes and carrying out a response to electrical stimulation that is alterable upon interaction with at least one of the plurality of analytes;
a plurality of electrical interfaces contacting the plurality of biosensing recognition elements;
stimulation circuitry, associated with the plurality of electrical interfaces, for delivering the electrical stimulation to the plurality of biosensing recognition elements; and
sensing circuitry, associated with the plurality of electrical interfaces, for sensing the response of the plurality of biosensing recognition elements to the electrical stimulation.
11. The implantable biosensor device of
12. The implantable biosensor device of
13. The implantable biosensor device of
14. The implantable biosensor device of
15. The implantable biosensor device of
a lead switch operably connected to the plurality of electrical interfaces.
16. A method of sensing an analyte in a patient, the method comprising:
implanting a biosensing recognition element in the patient, the biosensing recognition element being capable of interacting with the analyte and carrying out a response to electrical stimulation that is alterable upon interaction with the analyte;
electrically stimulating the biosensing recognition element;
detecting the response of the biosensing recognition element to the electrical stimulation; and
relating the detected response with an amount or presence of the analyte.
17. The method of
18. The method of
altering or initiating treatment of the patient based on the detected amount or presence of the analyte.
19. The method of
monitoring viability of the biosensing recognition element.
20. The method of
The present invention relates to sensors for detecting an analyte in a patient. In particular, the present invention relates to implantable cell/tissue-based sensors for in vivo detection of an analyte.
Numerous diseases and pathophysiological states are associated with deviations from normal concentrations of analytes in a patient's blood or tissues. Congestive heart failure (CHF), for instance, causes significant morbidity and mortality, and the healthcare expenditure for this disease is substantial. While in vitro diagnostic assays to measure various analyte levels in the blood are now in use, these assessments are point-in-care assessments that do not provide the clinician a complete profile of a patient's changing status. The inability to determine when a patient's CHF is worsening (before a patient gains several pounds in weight and/or edema is greatly increased) until the patient has a doctor's appointment or requires hospitalization will result in a delay of treatment. Moreover, required changes to the patient's therapy will be delayed.
Implantable biosensors have recently become an important tool for analyzing and quantifying analyte compositions in a patient's blood which could be used for initiating therapy, conducting diagnostics or monitoring. Cells and/or tissues within the patient's body may act as sensors to detect and monitor these analyte concentrations. For early detection of disease or change in disease such as CHF, it is desirable for the implantable biosensor to be sensitive to changes in analyte levels.
The disclosure relates to a cell/tissue-based device and method for detecting and/or monitoring an analyte in a patient. A biosensing recognition element, which specifically interacts with the analyte, is implanted within the patient. Stimulation circuitry stimulates the biosensing recognition element, which evokes a response that is altered when the biosensing recognition element interacts with the analyte. Sensing circuitry detects the response and produces a sensor signal, which is related to an amount or presence of the analyte.
The following detailed description is merely exemplary in nature and is not intended to limit the invention or the application and uses of the invention. Furthermore, there is no intention to be bound by any expressed or implied theory presented in the preceding technical field, background, brief summary or the following detailed description.
For the sake of brevity, conventional techniques related to implantable medical device telemetry, implantable medical device data processing, data communication protocols, computer network architectures, user interface generation and manipulation, and other functional aspects of the systems (and the individual operating components of the systems) may not be described in detail herein. Furthermore, the connecting lines shown in the various figures contained herein are intended to represent example functional relationships and/or physical couplings between the various elements. It should be noted that many alternative or additional functional relationships or physical connections may be present in a practical embodiment.
Biologic agent 14 is encapsulated within permeable membrane 16. Membrane 16 is a barrier to prevent cells of biologic agent 14 from migrating or being dislodged while allowing nutrients, waste products, etc. to diffuse to and from biologic agent 14. It also prevents large molecules and cells from interacting with biologic agent 14 that could result in immunological reactions and rejection of biologic agent 14.
Typically, membrane 16 is about 10 mm or less at its largest diameter. However, the size will vary depending on the analyte being monitored and the placement of element 12. Suitable materials include, for example, about 50 □m to about 100 □m thick polysulfone, polyvinylchloride/polyacylnitrile or a copolymer of polyvinyl chloride acrylic. The material should have a molecular weight cut-off no larger than about 100,000 Da but preferably about 30,000 Da to about 50,000 Da.
In some embodiments, it may be suitable to include a vascularization-promoting material on the outer surface of membrane 16. The architecture of this material promotes vascularization around biosensing recognition element 12 by allowing cellular penetration through the material. The increased vascularization creates a healthier environment for maintenance of biologic agent 14.
Electrodes 18 a, 18 b and 18 c, which are collectively an electrical interface, are attached to the outer surface of membrane 16. Conductor 20 a connects electrode 18 a to stimulation circuitry 24, conductor 20 b connects electrode 18 b to sensing circuitry 26 and conductor 20 c connects electrode 18 c to stimulation circuitry 24 and sensing circuitry 26. Stimulation circuitry 24 is connected to sensing circuitry 26 and power source 28. Sensing circuitry 26 is additionally connected to telemetry circuitry 30, which, in turn, is connected to power source 28.
Device 10 may be configured with two electrodes. In this embodiment, both electrodes are shared for stimulation circuitry 24 and sensing circuitry 26. Alternatively, device 10 may be configured with four electrodes, where two electrodes are associated with stimulation circuitry 24 and two electrodes are associated with sensing circuitry 26. With the latter embodiment, a better measurement of the action potential may be obtained, because interference caused by polarization of the electrodes is reduced.
Power source 28 may be one or more batteries or another implanted medical device coupled via electrical leads, for example. Any power source adapted to provide long-term use may be used in conjunction with device 10.
Housing 22 is hermetically sealed to protect circuitry when implanted. It is initially programmed and then device 10 is implanted into a patient. Biosensing recognition element 12 is positioned in an area of the body where interaction is likely with a specific analyte for detection and/or where detection in a specific location, such as in or around the heart, is desired. Implantation of element 12 may be in patient tissue or within the patient's vascular system. Examples of analytes that may be detected by device 10 include electrolytes, hormones, amino acids/polypeptides/proteins, carbohydrates, lipids, neurotransmitters, drugs, etc. Some specific examples include glucose, lactate, creatinine, troponin T, troponin I, thrombin, B-type nutrient peptide, catecholamine, potassium, calcium, etc.
Once implanted, telemetry circuitry 30 allows device 22 to be reprogrammed as desired. Telemetry circuitry 30 may be capable of long range communication and can include a patient and/or external alert as described in commonly assigned U.S. Pat. No. 6,169,925. The alert notifies the patient or a health care facility if anaylte concentrations fall outside an acceptable range.
To detect an analyte of interest, an electrical stimulus is generated by stimulation circuitry 24 and proceeds along conductors 20 a and 20 c to electrodes 18 a and 18 c, respectively. The electrical stimulus may be any of a number of types of waveforms such as monophasic, biphasic or multiphasic electrical voltage or current pulse. The electrical stimulus then propagates across biologic agent 14. Interaction between the analyte and biologic agent 14, which is discussed in more detail below, alters depolarization and repolarization initiated by the electrical stimulus thus altering the electrical response of biologic agent 14. The electrical response detected from biologic agent 14, which can be an electrogram or impedance spectra, is detected by electrodes 18 b and 18 c and transmitted to sensing circuitry 26 via conductors 20 b and 20 c, respectively.
Typically, sensing circuitry 26 processes the data representing the evoked response. For example, one or more parameters from each action potential would be extracted to determine whether or not the parameter(s) fall within an expected range. The data would be further processed with algorithms and a microprocessor to describe the distribution of the parameter(s) and how the parameter(s) have changed over time.
The gathered and processed information is transmitted to telemetry circuitry 30 where it is stored and then transmitted to an external device and then, for example, to a healthcare facility for review. Periodic transmission would occur, for example, once a week. The Chronicle™ System and CareLink™ Network, both from Medtronic, Inc., are systems that may be used to collect and transmit the information from device 10 to a healthcare facility.
Electrically stimulating biologic agent 14 prior to detection provides a more sensitive and accurate measurement of the effect of the analyte on the electrical response. The electrical stimulus simultaneously delivers a depolarization signal to essentially all cells within biologic agent 14. Under these conditions, the maximum amount of detected electrical response is larger than without prior stimulation. Thus, the spectrum between maximum and minimum readings is wider allowing more specific and accurate correspondence between the detected readings and the concentration of analyte.
Biologic agent 14, as described above, forms the basis of biosensor device 10 and is comprised of tissue or cells. Because of its importance, sensing circuitry 26 may also be used to monitor the viability of the tissue or cells to minimize risks that altered evoked responses are due to, for example, dead or dying cells or tissue instead of the presence of an analyte. Monitoring may be carried out by varying the timing of the stimulation from stimulation circuitry 24. The time from stimulation to the action potential is then measured and used to determine if biologic agent 14 is viable.
The tissue or cells of biologic agent 14 may be any of a number of types but are typically excitable such as cardiac myocytes or neurons or are genetically modified to produce a detectable electrical response.
The cells or tissue may be derived from various animal sources but are usually human. Cells or tissue derived from the patient may also be used.
The cells or tissue may also be derived from allogeneic or syngeneic stem cells. The stem cells, which may or may not be genetically modified, are cultured to differentiate into an appropriate tissue or cell type.
The cells or tissue may be modified at a molecular, genetic and/or cellular level. Molecularly modified cells or tissue are treated either in vivo or in vitro with a component that modifies a function or activity of the tissue or cells. Such components include, for example, cytokines, growth factors and hormones.
Genetically modified cells or tissue are engineered to include stable or transient sequence that is expressed by the cells or tissue. The expressed product is typically protein. The sequence may express a product normally expressed by the cells or tissue such that the cells or tissue now overexpress the product, or the sequence may express a product that is foreign to the cells or tissue. Alternatively, the sequence may express a chimeric product that is a combination of the two or it may express a mutant/modified version of a normally expressed product.
In addition, the cells or tissue may be genetically modified to alter the level of expression of a specific gene. For example, a gene may be regulated and normally only expressed under specific conditions. Regulatory elements of the gene can be modified such that the gene is constitutively expressed.
Cellularly modified cells or tissue have altered intracellular and/or extracellular matrices or growth architecture that affect cellular activity or function. For example, cells may be cultured in specific geometric configurations such as in circular patterns.
With respect to device 10, cell 34 is useful in detecting the effect of substances such as pharmaceutical agents or toxins. Many substances can effect cellular action potentials. In this embodiment of device 10, those effects can be monitored to indicate the effect of the substance, whether or not cells within the patient are responding appropriately or to titrate an appropriate dose of a particular substance to evoke a particular response. In addition, the effects of combining medications can be monitored.
In order to increase the sensitivity of the cells or tissue, cells may be genetically modified to overexpress channel proteins such as subunits 44.
In some instances, it may be beneficial to detect two different or two forms of a protein. For instance, device 10 may be used to detect combined concentrations of troponin I and troponin T. A cell type represented by cell 52 in
Some examples of membrane channel proteins that are useful with the present invention are listed in Table 1. Table 1 also indicates each proteins function and the corresponding gene from which it is expressed.
As noted above, electrodes 18 a, 18 b and 18 c may be attached to the outer surface of membrane 16.
In addition, electrodes of the present invention may take on various configurations.
In another variation of the present invention, an array of biosensing recognition elements 12 may be used for detecting multiple analytes.
Biosensing recognition elements 12 a-12 f are each configured essentially identical to biosensing recognition element 12 shown in
For example, element 12 a detects analyte A, element 12 b detects analyte B, etc. Device 10 can be programmed so that element 12 a is stimulated and its response is sensed first. Then, element 12 b is stimulated and its response is sensed second. This process continues through to element 12 f. Device 10 can be programmed for any pattern of switching between biosensing recognition elements 12 a-12 f. In addition, array 64 can accommodate additional or fewer biosensing recognition elements as desired.
In an alternate embodiment, a single membrane 16 may encompass array 64 instead of individual membranes 16 encompassing each of elements 12 a-12 f. A single membrane 16 around array 64 could be easier to assemble but there would be increased risk of migration of the various biologic agents.
As noted previously, biosensing recognition element 12 can be implanted into any of a number of locations within a patient.
In another representative embodiment shown in
Device 10 or device 60 may be stand-alone products or be integrated as part of a therapy delivery device. Such therapy delivery devices include implantable pacemakers, defibrillators, cardiac resynchronization therapy systems, drug pumps or any other means known in the art. The integrated devices may be programmed such that patient treatment is automatically altered or initiated based on the detected analytes. Alternatively, treatment provided by the integrated devices may be altered or started by a clinician after analysis of data gathered from the integrated device.
The stimulation of cells in a cell/tissue-based sensor and detection of the evoked response provides more accurate and sensitive in vivo detection of an analyte. This not only results in earlier and/or better treatment for the patient but also potentially decreases healthcare costs. Without analyte detection, signs of disease or worsening conditions may only be seen after the disease or condition has significantly progressed to later stages making treatment longer and more difficult.
Although the present invention has been described with reference to preferred embodiments, workers skilled in the art will recognize that changes may be made in form and detail without departing from the spirit and scope of the invention.
Patent Citations
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text:
Free Female Condoms for D.C. High Schoolers
Filed under: In The News
Condoms -- they're not just for guys anymore.
Washington, D.C. officials announced that 500,000 female condoms will be distributed free of charge in areas of the city that have been found to have high rates of HIV. The prophylactics will be distributed at various D.C. locations, including high schools.
Although many cities offer free male condoms, this project will make D.C. the first city to distribute the female version, according to the Washington Post.
Funding for the condom giveaways comes from a $500,000 MAC AIDS Fund grant.
The Post says the new program is "an official acknowledgment of the futility of relying solely on the use of male condoms" to stop the spread of HIV and AIDS.
The goal is to make female condoms as ubiquitous as the male version. Director of the D.C. HIV/AIDS Administration Shannon Hader tells the Post the program is intended to "build on what already exists ... to expand options rather than limit them."
Here is a YouTube video that shows how to put on a female condom.
Related: Female Condom as a Barrier Method of Birth Control
Ask Us Anything About Parenting
ReaderComments (Page 1 of 1)
3-09-2010 @ 10:24AMTara said...
I asked my mom about these when I was in HS.
her response was they seemed like trash bags.
We bought some for fun, and... they do. Its odd how these are supposed to work, they seem like it would slip from place.....
3-09-2010 @ 4:19PMElizabeth said...
It's about time, that's all I can say. Let's make women equally responsible for protection against HIV. Instead of your boyfriend saying he doesn't want to wear a condom, wear one yourself. Brilliant. I love it, and I wish more cities would follow suit.
3-10-2010 @ 2:40AMmbjisajjfan said...
Good for D.C.
Hopefully these condoms come with complete information and proper instruction on how to use them correctly because I'm sure there are very few young girls who are familiar with them...
AdviceMama Says:
Start by teaching him that it is safe to do so.

subset: commoncrawl


text:
6 Things That Cause Concentration Disappear
The following 6 Things That Cause Concentration Disappear :
1. Low vitamin or hormoneNot concentrate could be a sign that you lack certain vitamins or hormones. To prevent this, consult a doctor and consult your health condition. If necessary, ask your doctor for a blood test.
2. Unstable hormoneIt is more common in women at the age of menopause is characterized by 'hot flushes' (signs of changes in hormone levels) as well as elevated levels of gonadotropin hormones. If you experience this, th


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1. UConn is favored by 3.5 over Butler tonight. Is it too high, too low or just right?
2. UConn has won 10 games in a row. Butler is playing in a second consecutive National championship game. Who are you rooting for?
3. Spurs end their 6-game losing streak with a 114-97 win over the Suns. The Lakers lost to Denver, 95-90. San Antonoio has a 2 ½ game lead in the Western Conference. Based on what you saw yesterday, can the Lakers catch the Spurs in the West?
4. The Rangers swept the Red Sox. Texas hit 11 home runs in the three game series, with the Sox staff giving up a 10.57 ERA. Skip has been critical of the Boston pitching staff. How worried should the Red Sox be?
5. After sitting out for two months, Shaq sprained his right calf yesterday after playing only 5 minutes. What are the Celtics playoff chances without Shaq?
6. Both of you think Brad Stevens will be at Butler for the long haul. How much would a win tonight change that?
7. National championship game: No. 3 UConn vs. No. 8 Butler. Which team wins and why?
8. Mayors and other leaders from Los Angeles and San Francisco on Sunday condemned violence among sports fans in the wake of an Opening-Day beating at Dodger Stadium that left a Giants fan in a medically induced coma. What can be done to prevent this?
9. Despite his erratic play so far this year, Tiger Woods is the favorite to win the Masters at 8-1, followed by Phil Mickelson at 10-1. Should Tiger be the odds on favorite?
10. With Maya Moore's collegiate career over, is she the greatest women's college basketball player of all-time?


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Bruins lucky they're not choosing
|05.26.10 at 7:24 pm ET
As long as they stand pat with the second overall choice in the 2010 NHL Draft, the Bruins are going to get a tremendous difference-maker in the form of Taylor Hall or Tyler Seguin, the former an easy replacement for Phil Kessel and the latter a center often likened to Steve Yzerman. Both are impressing at the NHL Scouting Combine and both will be immediate contributors to top lines.
Which one they end up with at this point remains up in the air. Compare this draft to the 2007 NBA Draft, which featured Greg Oden and Kevin Durant: If you're picking in the first two selections, you sit back and take whichever can't-miss prospect (being kind to Oden) doesn't go No. 1. Outside of the NHL Central Scouting Bureau ranking Seguin as the top player in the draft, nobody seems willing to risk their credibility by saying one will have more of an impact than the other.
"I think it's very close," Mike Vellucci, coach of Seguin and the Plymouth Whalers (OHL), told WEEI.com. "The things that set them apart is that Taylor Hall has played in the league for three years, and he's been on a really good team for two of the three years. Seguin's only been in the league two years, so it's close. Hall is about a year older, but talent-wise it's really close.
"One's a center, one's a winger, so who do I believe in? I believe in Tyler Seguin because I've been up-close and personal with him. I know what a great character kid he is. Saying that, Taylor Hall, I've coached against him about 40 games in the last three years and he's a pretty good talent."
So with less than a month to go until the June 25 draft in Los Angeles, the Edmonton Oilers, who are in such rough shape that their best bet is to try to distinguish between the two immense talents and pick the better player, have yet to make up their minds, or say so at least. Edmonton GM Steve Tambellini and the Oilers have done their homework on Hall and Seguin, both of whom led the OHL with 106 points, but the man controlling the Bruins' fate didn't tip his hand on which direction the team is leaning.
"Over the last year and a half I've sat down and had dinner with both of them individually, gotten to know them as people," Tambellini said in an interview with NHL.com. "They're both great people. Any team is going to be so fortunate to get either of those two players."
Wideman's season an odyssey
|05.19.10 at 8:31 pm ET
The roller coaster that the Bruins went through in 2009-10 was mirrored by one of their key players. It seemed as Dennis Wideman went, so went the Bruins and for a good stretch of the season Wideman was not going.
The defenseman played three less games than he did a year ago (79 to 76) but scored 20 less points, down to 30 from a career high of 50. When he is going good, Wideman can be an assist machine with his dangerous shot from the point, second only to probably Zdeno Chara in terms of effectiveness (Johnny Boychuk has Wideman beat in terms of pure power). He has never scored more than 13 goals in a season, not bad for most defenders especially considering the scheme that coach Claude Julien employs. Julien has been activating defensemen from the blue line in the last two years more often but the way the plays work is that it is usually from the off point that will crash the net while Wideman takes the shot. That makes for some nice helpers along the way but not always finding the back of the net.
After a decent start to the year, Wideman started having trouble after the Winter Classic. He registered a -12 and only four points between Jan. 1 and the Olympic break, with two of those points coming in the final game against Florida. It was no coincidence that the Bruins were absolutely wretched during that period. Wideman was a ghost on the ice except when he appeared just so he could turn the puck over at the blue line. Julien relies on his defense to get pucks at the net and play solid on the point and on the walls and Wideman was doing none of that.
"I think the last part of the season I played really hard, I played quite a bit better," Wideman said. "The middle of the year got a little frustrating and I let it get to me a little bit too much. Going through a couple things and injuries and stuff like that and it just kind of compounded and lost some confidence and it took me a while to get it back."
Wideman said that the injuries were not serious. A little bit of a shoulder tweak here, a wrist there. They bothered him but he said he did not miss any games because of them. Really, it was all about confidence, or lack thereof.
"Just some nagging stuff that I didn't really talk about. Just some nagging stuff," Wideman said. "I wasn't really that just lost confidence and got completely frustrated with everything that was going on and had a problem rebounding. Then there was all the other stuff that was going on with throughout the year and just got frustrated and lost confidence."
It was hard for the media to ignore Wideman in January because his play was just absolutely terrible. It came down to the point where Julien, who had mildly dissed to the media after practice one day, refused to answer any more questions on the defender or any other "specific questions on players." That moratorium lasted all of one day as Julien ended up answering a question from this reporter about Trent Whitfield the next day, but the incident was the highlight of the low times for Wideman and the Bruins. For Wideman specifically, he knew things were going bad when the denizens of TD Garden started giving him the Bronx cheer.
"Probably the first game that I started to get booed there [was the worst]," Wideman said. "Around December at the end or something like that."
Somewhere after the March 18 game against the Penguins, things started to pick up for Wideman. He still had a turnover problem but the hits were coming back (though he not known for his especially physical play) and observers could tell that he was more mentally in it when he started throwing his body around to block shots at the point. He picked up a couple points against Calgary in late March and ended up playing big minutes along with the other surviving defensemen when Dennis Seidenberg and Mark Stuart went down and Andrew Ference was still not healthy enough for games. Wideman's confidence grew. He doesn't know how, it just did.
"I don't know, just played a couple good games and forget about the stuff that happened before and just build on it and build on it and a couple months stretch things just started to turn around," Wideman said.
In the playoffs, Wideman was one of the Bruins top players. He blocked shots, he took shots, he moved the puck through the neutral zone. His signature play (which would have been more of a defining moment if the Bruins had one the game) was in Game 7 against the Flyers when he took a broken breakout, reset the rush himself and took the puck into the offensive zone, all the way down to the corner and centered it to Milan Lucic who was crashing the net for the goal and a 3-0 lead in the first period.
It was the last goal the Bruins scored all season.
Wideman ended the playoffs as almost a point per game player with 12 (a goal and 11 assists) in 13 games. He was a +3 though that number was higher before the Flyers comeback.
There are whispers that Wideman could be traded. That could be good for the Bruins, especially after the season he just had. But, when the good Wideman is around, the Bruins are definitely better. He knows he cannot control it but understands if that is the direction that Peter Chiarelli wants to go.
"I can't control that. If he wanted to trade me then that is part of the game," Wideman said. "It is never fun being traded, you want to stay with the team you are with, I love it here and I like Boston. I don't want to but I can't do anything about it if that is what the organization decides to do."
Sturm undergoes successful knee surgery
|05.18.10 at 2:57 pm ET
Bruins general manager Peter Chiarelli issued a press release Tuesday afternoon announcing that forward Marco Sturm underwent successful surgery to repair his right knee. The surgery entailed ACL reconstruction, MCL repair and partial lateral meniscectomy and was performed by Dr. Peter Asnis at Massachusetts General Hospital. Sturm injured the knee in the first period of Game 1 of the Eastern Conference semifinals when he pushed off to make a check on Flyers defenseman Matt Carle and torqued his knee on the ice at TD Garden. Sturm is expected to rehab for six months.
Here is the press release from the Bruins media relations staff:
Boston Bruins general manager Peter Chiarelli announced today that forward Marco Sturm underwent successful surgery on his right knee. The surgery ' which entailed a right knee ACL reconstruction, MCL repair, and partial lateral meniscectomy ' was performed by Dr. Peter Asnis at Mass General Hospital.
Sturm sustained a torn ACL and a torn MCL in his right knee during the first period of the Bruins-Flyers game on Saturday, May 1 (Game 1).
His expected recovery time is an estimated six months post-surgery.
Sturm is a veteran of 855 NHL regular-season games and has registered 234 goals and 232 assists for 466 points in his career. The 31-year-old tallied 22 goals and 15 assists during the 2009-10 season, marking the seventh time in his career he surpassed the 20-goal plateau. He played in seven playoff games this season and has scored eight goals and tallied 11 assists in 52 postseason games for San Jose and Boston.
Boychuk has little doubt he will be back
|05.18.10 at 2:42 pm ET
Johnny Boychuk is the type of guy who will be laughing, joking and making sarcastic remarks when things are going well. When things are not, he tends speak quietly about what went wrong.
Boychuk was definitely quiet Tuesday morning during breakdown day at TD Garden. He becomes a Category 6 unrestricted free agent this offseason even though he does not technically have the service time in the NHL to make him unrestricted. Category 6 is a rare designation for guys who normally spend most of their time in the minors and then become free agents after their initial contracts expire. To be a restricted free agent, which would make general manager Peter Chiarelli's job in keeping him in Boston much simpler, Boychuk would have needed to complete 80 career games this year and be under the age 26, marks he missed by 12 games (including playoffs) and sixth months. Boychuk spent most of five seasons in the minors before coming to Boston and his progress towards becoming a productive NHL defenseman was hindered while he was in the Colorado system as it tried to make him into a dual defenseman/power forward. For a simple guy like Boychuk who likes to hit things and take big shots, forward is probably too complicated a position.
"Just try to keep it simple. Get the puck away try to turn pucks over, simple. I got more comfortable and then tried to do a couple different things. Nothing drastic, I just wanted to keep it simple," Boychuk said. "I just wanted to get pucks to the net and keep it simple. Simple is my way, I guess."
In terms of staying in Boston, Boychuk has little doubt that he will be back.
"Everybody knows that I want to be in Boston. So, I want to be here, it is not a big secret," Boychuk said. "100 percent. I love it here in Boston. I want to be back."
Boychuk said that he has not even thought about what would happen if another NHL team threw a lot of money at him come July 1. He hopes that it will not even make it that far.
"Well, they can't talk to me before July 1. I hope it doesn't go that long," Boychuk said. "No talks but I am pretty sure that I am going to be back, I hope I am going to be back at least. So, we will see."
The defenseman is going to take a short vacation and ship his truck back to Montana for the purpose of driving to his home in Edmonton where he will spend the summer. He said that he does not look forward to the 10-hour drive across the nothingness that lays between Minneapolis and the Rocky Mountains. Anybody who has driven through those plains would probably agree. In terms of the pack up, Boychuk still is a little stunned about the Bruins sudden exit at the hands of the Flyers and knows that, if he is back next year, the memory will light a fire under the team.
"I don't even think I should be here packing up my stuff. It was weird packing my stuff last night to go back up [to Edmonton]. So much stuff to do now. Drive home, fly home. However I am getting home. Haven't really had any time to watch hockey. Just packing up everything and try to get everything settled before we leave," Boychuk said. "It is going to light a fire, that is for sure. Hopefully we take this next year and use it to our advantage."
Ward on D&H: 'Boston's on the upswing'
|05.18.10 at 12:54 pm ET
Former Bruin Aaron Ward, who is serving as an analyst for NHL coverage on Versus, joined the Dale & Holley show Tuesday to talk about the Stanley Cup playoffs. To hear the interview, click on the Dale & Holley audio on demand page.
Ward said the Bruins were in a difficult situation in their series vs. the Flyers. "It's tough to overcome the loss of your two top scorers in Marco Sturm and David Krejci. And then couple that with Philadelphia getting back Simon Gagne. That's a tough one to deal with," said Ward, who finished this season with the Anaheim Ducks.
Ward said Bruins fans can take solace in the fact that the future is bright for this team. "Boston's on the upswing. They've got a great situation now with the draft, they've got a great situation where they have a lot of key, young guys that have that experience in the playoffs, regular season, that familiarity with the city. And it means a lot to a team to where you can start forming some sort of consistency and looking toward becoming a dynasty."
Ward, who said he would return to Boston "in a heartbeat," defended the leadership of Bruins captain Zdeno Chara, saying: "He possess every intangible. … He knows when to say something and when not to."
Ward was traded by the Bruins last offseason to the Hurricanes. There he became teammates with Scott Walker, who sucker-punched Ward in the face during their playoff series last season. Ward said it didn't take long to put hard feelings aside. "The first phone call from a player [after the trade was finalized] was Scott Walker," Ward said. "That was pretty easy to deal with, because we aired it out right there, put it right on the table, and there was no issue. We're big boys. One of the things I found out right after that punch was that Scott's wife had cervical cancer, and that was the day he found out. So, you know what, there's times in the game as a player, as a human, you figure out you've got to cut him some slack because you never know what kind of frame of mind you'd be in in that situation."
Thomas says it is 'too early' to dwell on offseason
|05.18.10 at 12:21 pm ET
Bruins goaltender and reigning Vezina Trophy winner Tim Thomas spoke about his upcoming role on the team after having been usurped for the No. 1 spot in the crease by rookie Tuukka Rask in the second half of the 2009-10 season. Thomas signed a four-year $20 million contract extension last summer and has a no-trade clause in his contract though the speculation is that general manager Peter Chiarelli will have no choice but to try and move Thomas's contract. Thomas said on Tuesday morning that there are questions that he needs to answer but it is still "too early" to start coming to any conclusions.
"Too early. Those kind of thoughts are something that need to be thought over carefully and over a longer period of time and I haven't had the luxury of doing that yet," Thomas said. "Even if you are not playing at the end of the year you are still practicing with the team, you are still trying to get yourself in a position where you could help the team if you are called upon. So, I was busy doing that stuff and not thinking about, or at least coming to conclusions on the things you guys are asking me about. Of course they have crossed my mind because I am human and they have to, you know."
Thomas said that he just has not had any time between the Game 7 loss last Friday and Tuesday morning to figure out how he wants to deal with the offseason.
"It is so early after the end of the season that I haven't took the time yet. We have had these end of the year meetings, get our equipment, we have had some other activities. Over the next month I will let things kind of settle in my mind and come up with some of that stuff later, but not yet," Thomas said.
Thomas also said that the 2009-10 season was a unique experience in his professional career. Coming from being the top goaltender on the best team in the Eastern Conference and watching his team, and his job, dissipate would be unique for any player.
"It was certainly different than any other experience I have had as a pro," Thomas said. "It was challenging, you go through these types of situations and years and you just have to try and find the lessons out of them and find a way to make yourself a better pro goaltender and a better person."
Neely on The Big Show: 'It's been a rough few days'
|05.17.10 at 8:59 pm ET
Hockey Hall of Famer and Bruins vice president Cam Neely called in to The Big Show on Monday afternoon to discuss the aftermath of the Bruins' heartbreaking Eastern Conference semifinal loss to the Philadelphia Flyers and talk about the future of the club with the NHL draft, free agency and other big personnel decisions coming up this offseason.
'We're going to look top to bottom,' Neely said. 'Obviously, when you don't win the last game of the hockey season, you have to improve your club, so we're looking at all ways at doing what we need to do to improve the club.'
A transcript of that interview follows. You can listen to the entire interview on The Big Show audio on demand page.
Has the Game 7 loss hit you guys yet?
Oh, it hit hard. It hit hard on Friday night. It's been a very tough few days, as you can imagine. Obviously, losing in the finals is a big deal, but this is really big, too.
Should the David Krejci injury and the return of Simon Gagne be seen as the turning point of the series, or when you're up 3-0, should you win the series even when you're up against those injuries?
Yeah, I think when you're up 3-0 you have to find a way to close it out. Losing Krejci certainly hurt us. That was a big loss because what it did was we had to give Savard more minutes, and you know him stepping into the playoffs in the second round not in the condition the other players were, being out so long that he was. It was a big loss losing Krejci. Gagne, he came back and got some big goals for them at timely times in all of the games that he played in. But when you're up 3-0, you have to find a way to close it out.
From the front office perspective, where do you start looking [players, coaches, etc.] for what went wrong with that series?
Well I think we have to look at the season as a whole, to be honest with you. The year as a whole didn't go as we expected it to. Certain players didn't perform to the expectations. Then, we found a way to make the playoffs and got out of the first round. Quite frankly, I don't think a lot of people thought we would beat Buffalo, and we came out, played really well and were able to solve [Ryan] Miller and then get up on Philly 3-0.
So I think over the course of this next week, we're going to sit down as a group and really just evaluate the whole season. I don't think we should just look at it in this one little snapshot because the year as a whole didn't go quite the way we had planned or expected. Read the rest of this entry »
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I've never had to pay a deposit for room key & TV remote, at a motel in my life, that was $10. The room smelled awful! Left the door open and the air on ~ impossible to get rid of the stink. The mattress was broken on one side. Disgusting stains in the bath tub. Broken drawers. Light switch broken. Had to ring the bell to get back the deposit and had to stand there for over 5 minutes. Saw a bug on the wall upon departure ~ could not get out of there fast enough. The price wasn't reasonable at all for this DUMP!
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Learn about the Coalition for National Trauma Research (CNTR), of which the WTA is a member.
The WTA lost 5 members during 2013. Since its beginning, our Association has lost 9 members. At the 2014 WTA meeting, the Board of Directors passed a resolution to memorialize each departed member's life on our website. Click here to see the page dedicated to the life of Past President M. Gage Oschsner, M.D.
Read a note from the WTA Historian
Welcome to the WTA
The 45th Annual Meeting was held March 1-6, 2015 in Telluride, Colorado, with record attendance.
Download the 2015 WTA Program Book!!
First, IF YOU DO NOT HAVE an app on your device, download a free e-Book reader app from your device's app store. You must have an e-Book reader app in order to access and open the e-Program Book.
Click HERE to obtain CME credits for the meeting. All information must be submitted no later than Friday, March 20th to receive CME and/or self-assessment credits.
The next annual meeting of the Western Trauma Association will be held at the Resort at Squaw Creek in Squaw Valley, California, from Februay 28 through March 4, 2016. Look for abstract submission to begin this summer.
NEW!! History Section
The WTA has been developing an archive of WTA historical documents and presidential interviews which are now being posted on the web. You can always find the historical section under the About menu tab above. For now, you can also click here.
About the WTA
The Western Trauma Association is committed to the improvement of trauma care through research, education, sharing of clinical experiences, and the development of physicians of all specialties who are involved in the care of trauma patients. The goals of the Association are not only the intellectual growth attained through increased knowledge, but also the emotional growth attained through camaraderie and interaction with family and friends in an environment conducive to winter sports.
|Western Trauma Association © 2002-2011
All Rights Reserved
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the last 1,000 customers:
from CustomInk again
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Neil Greenberg premieres This at New York Live Arts. Choreographer Neil Greenberg doesn't like the word "about," as in, "What is this dance about?" Having been a member of Merce Cunningham's company between 1979 and 1986 and having read Susan Sontag's influential 1966 Against Interpretation, he would prefer we not scramble to uncover "meaning" while watching what he puts onstage. The title … [Read more...]
Quiet Flowering
Jodi Melnick presents a trio, Moment Marigold, at BAM Fisher. When is a theme not a theme? When is a person not a persona? Jodi Melnick raises these questions in a brief program essay about her new Moment Marigold. She also noted that she begins the choreographic process by working in a studio by herself, letting movement ideas emerge. Creating this work, which premiered at BAM Fisher, she … [Read more...]
How Many Make a Solo?
Luciana Achugar and Amanda Loulaki present new solos in New York. When is a solo not a solo? Or perhaps the question might be this: Is a solo ever a solo—given that anywhere from two people to an audience of hundreds might be watching a supposedly solitary performer having a private experience? Luciana Achugar's new Otro Teatro was advertised as a solo, but, in fact, it was a solo with a … [Read more...]
Fire Burning at Both Ends
Donna Uchizono Company premieres Fire Underground at New York Live Arts. The title of Donna Uchizono's harrowing new work is Fire Underground. The words evoke flames smoldering, unable to break through. Fire under the skin. Fire heating up the brain. Anger that has to be restrained. Uchizono makes no secret of the dance's source. She spent twelve years adopting a child in Nepal and … [Read more...]
Life as Disorder, Order as Life
David Dorfman and Brian Brooks present new works in two of BAM's theaters. Choreographer David Dorfman wears his heart on his sleeve. As his newest work Come, and Back Again shows, it's a very big heart and an imaginatively tailored sleeve. His past works have tackled political, historical, and social topics, but always in warmly personal ways. He's not shy about friendship as a topic … [Read more...]
A Change in the Wind
Tamar Rogoff's Summer's Different in La MaMa's Ellen Stewart's Theater, April 24 through May 12 A family's summer day on the beach, what could be finer? Of course, someone might get sunburned, someone might drop her hot dog in the sand, someone might swim out a little too far. There could be bickering. Tears saltier than usual could be shed. But still. . .a cloudless sky, blue waves. … [Read more...]


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The Taigh (a Gaelic term for "home or dwelling") Scholarship was established to inspire and encourage residents of Peacham, Vermont, to pursue a post-secondary education. The donors of this scholarship understand the challenges that students from rural areas face, particularly those who are the first in their family to attend post-secondary school. It is the donors' intent that this scholarship help students seek to do more than they ever thought possible.
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Great for dogs who like to chew
posted 7 years ago
The best advice I ever got was to encourage my chihuahua mix to chew. So many little dogs develop dental problems later on in life, and unfortunately it causes other health problems. These bones are great for removing plaque and tarter from teeth. My Tucker really enjoys these bones and they last a while too. They have also given him a bright white healthy set of teeth.
Pros: Very long lasting
Cons: Expensive but cheaper than new shoes
2 of 2 people found this review helpful.
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Not as durable as original
posted 7 years ago
Good for your dog if they are not very hard on bones and toys.
Pros: My dog liked them
Cons: Not good for super chewers
5 of 5 people found this review helpful.
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Not as durable as the other Nylabone
posted 7 years ago
Whe my friend bought these for her 3 dogs, one of the dogs destroyed his pretty fast; the other 2 dogs took longer-or would have until the 3rd dog got hold of their bones. She plans to stick with the tougher Nylabone in future due to Pippin's style of chewing.
Pros: the dogs liked them
Cons: one of the dogs destroyed this quickly
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Property Details
Condo, 2 Bedrooms, 2 Baths, 4 Sleeps
This lovely golf course condo is ideally located in the community of Gator Trace Golf and Country Club, Ft. Pierce, FL. Walk next door to Country Club, golf pro shop, restaurant and lounge, pool area, shuffleboard and bocce ball courts.
Beautifully appointed first floor, 2 bedroom/2 bath condo located on the #1 Fairway of this 6136 yard (from the Blue Tees), par 70 golf course.
Each of the 2 bedrooms feature a king size bed (new King Mattress 2012 in Master Bedroom) and individual baths for complete privacy. The modern kitchen has a lovely breakfast area, electric stove,dishwasher (new 2012), microwave, disposal and refrigerator with ice
Both bedrooms and living areas offer ceiling fans. The living room and dining room overlook a small lake, the #1 fairway, green and unlimited open green space for complete privacy.
The furniture in the living room and dining room have been newlyy upholstered (April 2014) for a beautiful new fresh look. There are (3) televisions (a 27' stereo TV w/a DVD/ 5 disc CD Player in the living room, a 32' Flat stereo TV w/ a DVD/CD Player in the Master Bedroom and a 24' TV in the second bedroom. Cable TV and Internet service including WIFFI are included, Both bedrooms have carpeting (new carpet installed November 2013), the rest of the condo features upgraded 18' ceramic tiles for easy care. Central air conditioning, washer and dryer are also included. Dishes, cooking and baking utensils, pots, pans, silverware, linens, coffee maker, toaster, hand mixer, blender, drink mixer, electric choppers, can opener, and juicer, are available. Covered parking.
PLEASE! NO smoking and NO pets.
Daily Golf Rates, Golf and Pool Memberships are AVAILABLE for an additional fee. Contact Country Club directly for prices.
Special rates offered for 2, 3 and 6 month rentals. Contact owner for rate quotes.
Recent Review
Stay in Gator Trace
Dave and Joan
I think this was their first venture in renting a vacation home (condo), hopefully it will not be their last.
Unfortunately for us, they found the beach more to their liking than golf for future renting. If they ever change their mind we would welcome them back with open arms.
John and Theresa
About the Owner
6 Reviews
4.7 based on 6 traveler reviews
Stay in Gator Trace
Dave and Joan
I think this was their first venture in renting a vacation home (condo), hopefully it will not be their last.
Unfortunately for us, they found the beach more to their liking than golf for future renting. If they ever change their mind we would welcome them back with open arms.
John and Theresa
Relax & EnjoyRelax & Enjoy
for a delightful stay at Gator Trace, this is the place. All you will need are
your clothes, golf clubs & groceries. If you need a place for your computer(s)
you have it here. Wild life of birds, gators & golfers provide entertaining
sights. For golfers, it couldn't be more convenient, you don't have to drive to
work, just wave at a golf cart attendant & you will be delivered a cart. What
more can you ask for?
It has been a delightful stay and Lord willing, we will be back.
Dean & Nancy are every owners dream guests. They left our condo spotless. We had new guests' arriving the day after they checked out which is always a challenge for owners as it is such a quick turnaround time.
We look forward to them returning in the future...hopefully for a longer stay!
John & Theresa
Margaret and Dennis
We again enjoyed our stay at Gator Trace Golf Country Club. Your beautiful condo met all needs plus more. We don't play golf but enjoyed the beautiful golf course also watching the golfers and wildlife early in the morning. I would rate this 5 plus we had everything that we needed, and only had to buy our food.
The condo was close to our daughter, son-in law and our grand children so we met often.
We really enjoyed the barbecue gas grill for get together. Thank you so very much for the bottle of wine and beautiful flowers. What a lovely touch.
Dennis and Margaret from Saginaw, Michigan,
Second stay and what a wonderful place
John and Theresa Minter (Owners)
Great Time
He was a golfer, she was not, but they both enjoyed the beach throughout their stay. They preferred Pepper Beach on North Beach as it is tranquil and uncrowded and only 20 minutes from the condo.
They were also able to take sightseeing trips as the condo is located conveniently just an hour from Palm Beach, 2 hours from South Beach (Miami) 1 1/2 hours from the NASA Space Center and 2 hours from Disney World.
John & Theresa Minter (Owners)
Vacation 2010.
Condo that exceeded all our expectations
Location is just off US1 and a few miles to Port St. Lucie and plenty of restaurants of all price range.
We will return for another month is 2011!
Activity and Interests
*The Gator Trace Golf and Country Club is ideally located minutes from downtown Ft. Pierce (overlooking the Indian River) and Port St. Lucie.
*Only 15 minutes from the pristine beaches of Hutchinson Island.
*Enjoy golf, deep sea fishing, canoeing, dining, shopping and sight seeing.
*Situated 30 minutes South of Vero Beach, 50 minutes North of famous Palm Beach, 1 1/2 to 2 hours North of Ft. Lauderdale and the glitz of Miami, 2 hours South of Disney World and major Central Florida attractions.
Rental rates
|Rate Period
|Weekend Night
|Monthly *
Low Season
May 1 2015 - Dec 31 2015
28 night minimum stay
Jan 1 2016 - Apr 30 2016
28 night minimum stay
Low Season
May 1 2016 - Dec 31 2016
28 night minimum stay
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.
Additional information about rental rates
- Cleaning Fee $85.00
- Tax Rate 11.5%
A $1,000. deposit is due at the time the reservation is made to hold the unit on a definite basis.
Due(120) days prior to arrival: 50% of remaining balance;
Due (90) days prior to arrival: Final payment of remaining balance . There will be no refunds extended 91 days or less prior to arrival unless owner is able to rent the unit for the same period and rental rate.
POOL and GOLF memberships are NOT included in the quoted rates. Rates are subject to 6 1/2% Fl. State Tax and 5% County Resort Tax., plus a one time charge of $85.for a cleaning fee.
Arrivals begin on the first day of the month; departures are on the last day of the month. The monthly rate for February (arriving on the 1st with departure on the 28th.) is $2800. plus cleaning fee and taxes.
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Property Type
- condo
- Adventure
- Budget
- Historic
- Romantic
- Tourist Attractions
- Air Conditioning ...
- Clothes Dryer
- Hair Dryer
- Heating ...
- Internet ...
- Iron & Board
- Linens Provided ...
- Living Room ...
- Parking ...
- Telephone ...
- Towels Provided ...
- Washing Machine
- Coffee Maker
- Dishes & Utensils ...
- Dishwasher ...
- Kitchen ...
- Microwave
- Oven ...
- Pantry Items ...
- Refrigerator ...
- Stove ...
- Toaster
- Dining ...
- Dining Area
- Books ...
- DVD Player ...
- Games ...
- Satellite / Cable ...
- Television ...
Pool / Spa
- Communal Pool ...
- Outdoor Pool
- Long-term Renters Welcome
- non smoking only
- pets not allowed
- wheelchair accessible
Location Type
- Golf Course Front
- Lake View
- bay/sound
- botanical garden
- churches
- cinemas
- coin laundry
- festivals
- library
- live theater
- marina
- museums
- playground
- pond
- restaurants
- synagogues
- winery tours
Leisure Activities
- antiquing
- beachcombing
- bird watching
- horseback riding
- outlet shopping
- paddle boating
- photography
- scenic drives
- sight seeing
- walking
Local Services & Businesses
- ATM/bank
- Babysitter
- fitness center
- groceries
- hospital
- laundromat
- massage therapist
- medical services
Sports & Adventure Activities
- cycling
- deepsea fishing
- fishing
- golf
- hiking
- jet skiing
- sailing
- scuba diving or snorkeling
- snorkeling
- sound/bay fishing
- surf fishing
- surfing
- swimming
- tennis
- wind-surfing
Floor Area
- 1200 sq. ft.
- 2 Bathrooms
- Bathroom 1
- Bathroom 2
- The master bathroom spacious featuring a his and hers sink and a step in shower. The guest bathroom has a tub and shower and nice under counter storage space.
- 2 Bedrooms, Sleeps 4
- Bedroom 1
- Bedroom 2
- Each of the 2 bedrooms feature a king size mattress and lovely bedding. Ideal for one expecting guests during their stay or two couples sharing the accommodations.
- Golf ...
- Outdoor Grill ...
- Guests provide their own meals
- *Air Condidtioning *Electric Barbecue Grill (approved for condos) *Electric Stove *Micro Wave Oven *Cable TV & Internet Service with WIFI access *Telephone (local calls) *Ceiling fans *Linens provided *Iron/Iron Board *Televisions (3) *DVD Players (2) *CD Players (3) *Small Appliances (Coffee Maker, toaster, hand mixer, electric can opener, mini-food chopper, electric drink mixer, blender, electric juicer). *Dishes, silverware and cooking utensils *Refrigerator w/ ice maker *Dishwasher *Washer/Dryer


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Arizona Cardinals
Ryan Lindley holds dubious distinction, still looking for first TD pass
The beautiful thing about a win in the NFL, is that for at least a few days all of a team's persisting problems can be masked by the end result.
Take for instance last Sunday's 38-10 win by the Arizona Cardinals over the Detroit Lions. The victory snapped a season-high nine-game losing streak, but was largely the product of another tremendous performance by Arizona's defense (forced four turnovers, two returned for touchdowns).
Making his third career start in the contest, quarterback Ryan Lindley was rather uninspiring, throwing for 104 yards, to go along with one interception and no touchdown passes. Most of the offense was generated by an opportunistic defense, and Beanie Wells seemed to handle the rest of the load (career-high three touchdowns) in the red zone.
In fact, Lindley has yet to throw a touchdown in his first four career appearances, forcing some to wonder if he can even notch the career milestone in 2012.
According to ESPN Stats and Info, no quarterback since 2001 has thrown 91 passes or more in a season without connecting for at least one touchdown.
And as ESPN's NFC West blogger Mike Sando pointed out Saturday, Lindley currently holds the NFL record for most passes in a season (141) without a touchdown pass.
Lindley isn't alone though. Former Cardinal Matt Leinart also had a similar run of futility in 2009, failing to throw a touchdown in his first 77 attempts.
The task won't get any easier for the former sixth-round pick over the final two weeks of the 2012 season. Arizona faces two of the top six pass defenses in the league in Week 16 (Chicago Bears) and Week 17 (San Franciso 49ers).
Most Popular
Cardinals Audio
- Rodney Gunter, Cardinals defensive lineman - Tuesday May 26Rodney Gunter has been a "sleeper" player since high school.
- Tyrann Mathieu, Cardinals safety - Tuesday May 26Tyrann Mathieu says he is feeling healthy and discusses the mentality of the defense.
- Bickley Blast - Tuesday May 26Ray McDonald's violent tendencies emerge yet again.
- Pete Prisco, Senior NFL Columnist for CBSSports.com - Friday May 22Pete Prisco says the Cardinals are better now than they were a year ago.
- John Clayton, ESPN NFL Insider - Friday May 22John Clayton gives us insider insight into the NFL's top stories.


text:
Senators Express Concerns About Smithfield Foods Merger
Smithfield CEO Larry Pope tried to reassure lawmakers that the sale of his Virginia based company will not mean a transfer of jobs to China or a reduction in food safety. He appeared before lawmakers on the Senate Agriculture Committee on Wednesday.
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Certain Flame Retardants May Be Banned From Children's Products
OLYMPIA, Wash. (AP) — A Washington state Senate committee has heard stestimony on a bill to ban a...
Pink Slips Going Out at Hanford Nuclear Site
YAKIMA, Wash. (AP) — Cleanup work is likely to be slowed at the nation's most contaminated ...
< China Loosening One-Child Policy
Nov 15, 2013 09:52
Category: General News
Category: General News
Washington Health Insurance Must Meet Federal Reform Plans
SEATTLE (AP) - Washington state's insurance commissioner says President Barack Obama's proposal to extend old health insurance policies isn't a good deal for Washington citizens. Commissioner Mike Kreidler said he won't allow insurance companies to extend their old policies that don't meet the requirements of federal health care reform. An estimated 290,000 Washington residents have received notices that their old insurance policies will be cancelled.


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Explore the Entrepreneurship.org Resource Center to find resources. Designed with entrepreneurs in mind, our resource center allows you to find materials to grow great ideas.
Randy Komisar joined Kleiner Perkins Caufield and Byers in 2005 as a partner. For several years prior Randy has partnered with entrepreneurs creating businesses with leading edge technologies. He was a co-founder of
Claris Corporation, served as CEO for LucasArts Entertainment and Crystal Dynamics, and acted as a "virtual CEO" for such companies as WebTV, Mirra and GlobalGiving. He was a founding Director of TiVo where he is currently chairman of the
Nominating and Governance Committee. Earlier Randy served as CFO of GO Corporation and Senior Counsel for Apple Computer, following a private practice in Technology Law. Randy holds a BA in Economics from Brown University and a JD form
Harvard Law School. He is a Consulting Professor of Entrepreneurship at Stanford University and author of the best-selling book The Monk and the Riddle, as well as several articles on leadership and entrepreneurship. Randy frequently
speaks here and abroad on such topics.
Dr. John Hennessy has been President of Stanford University since 2000. He became a Stanford faculty member in 1977. He rose through the academic ranks to full professorship in 1986 and was the inaugural Willard R. and
Inez Kerr Bell Professor of Electrical Engineering and Computer Science from 1987 to 2004. A pioneer in computer architecture, in 1981 Dr. Hennessy drew together researchers to focus on a computer architecture known as RISC (Reduced
Instruction Set Computer), a technology that has revolutionized the computer industry by increasing performance while reducing costs. In 1984, he used his sabbatical year to found MIPS Computer Systems Inc. to commercialize his research in
RISC processors. Dr. Hennessy is a recipient of the 2000 IEEE John von Neumann Medal, a 2004 NEC C&C Prize for lifetime achievement in computer science and engineering, and a 2005 Founders Award from the American Academy of Arts and
Sciences. Dr. Hennessy earned his bachelor's degree in electrical engineering from Villanova University and his master's and doctoral degrees in computer science from the State University of New York at Stony Brook.
Mr. Davidson is the Chairman of Fenwick & West. He advises technology companies, including networking, computer software and electronics companies as well as medical technology companies. His clients range from
start-ups to Fortune 1000 companies, including: Cisco Systems, Inc. Electronic Arts, Inc. Intuit Inc. Macromedia Inc. Symantec Corporation Other clients include Barclays Global Investors, Kleiner Perkins Caufield & Byers, Mohr Davidow
Ventures, Morgan Stanley and Sequoia Capital.
Fern Mandelbaum, is a Partner at Monitor Venture Partners. Ms. Mandelbaum is an entrepreneur and CEO who specializes in creating and growing technology focused businesses. Since 1998, Ms. Mandelbaum has worked with CEO's
helping them develop and refine their business concepts, recruit management teams, key advisors and board members, implement fund raising strategies and establish strategic alliances. Her portfolio includes: New Vine Logistics,
CaseCentral, Informative, NapaStyle, WetFeet, Care2, and LiveAdvice (merged with Keen). She has worked with, and secured funding for her companies from many of the leading venture capital firms, including: Mohr Davidow; ATV;
Kleiner-Perkins; Draper Fisher Jurvetson; ThomVest; and Carlyle Ventures. Between 1991 and 1998, Ms. Mandelbaum was co-founder and CEO of Skyline Products, one of the premier toy invention firms that was sold to IDEO Product Development,
the largest design firm in the U.S., in 1998. Skyline achieved annual growth in excess of 200%, becoming one of the top toy invention firms in the U.S. She was responsible for all marketing, business development, financial, legal, and
strategic planning aspects of the company, and licensed over 80 products to 50 companies during her tenure. Between 1988 and 1991, Ms. Mandelbaum was a General Manager at Metcal. She created and managed a division to develop and
commercialize foodservice equipment incorporating Metcal's proprietary heating technology. Prior to, and while, attending business school, Ms. Mandelbaum worked at Bain and Company, SRI International as a research analyst in the financial
industries center, Hewlett Packard, creating the used equipment vendor program, and the Kyoto Shinyo Kinko, managing the initial stages of a new product introduction. Ms. Mandelbaum received her M.B.A. from Stanford Graduate School of
Business in 1988 and her B.A. in Economics from Brown University in 19
David M. Kelley is a California-based entrepreneur, educator, engineer, and venture capitalist. He was featured by Fortune magazine as one of the "People to Watch" and was selected for the "I.D. 40" list of America's
leading design innovators. In that listing he was described as "the most sought-after design engineer this side of Thomas Edison." He is the founder and CEO of IDEO Product Development, America's largest independent product design and
development firm. In addition to his work at IDEO Product Development, Kelley is a tenured professor at Stanford University in the school's innovative Product Design program. As a faculty member, Professor Kelley is interested in new
product development methodology from inception to production with an emphasis on user-centered design. He encourages broad understanding of product design methodologies, exposing his students to a variety of viewpoints in classroom
discussions and project work. Professor Kelley's primary involvement is in the product design program, a joint program with the art department which emphasizes the blending of innovation, human values, and aesthetic concerns into a single
curriculum. He also teaches in the Human Computer Interface program, which is a joint program with computer science.
Frank H. Levinson founded Finisar in April 1987 and has served as a member of our Board of Directors since February 1988 and as our Chairman of the Board and Chief Technical Officer since August 1999. Mr. Levinson also
served as our Chief Executive Officer from February 1988 to August 1999. From September 1980 to December 1983, Mr. Levinson was a Member of Technical Staff at AT&T Bell Laboratories. From January 1984 to July 1984, he was a Member of
Technical Staff at Bellcore, a provider of services and products to the communications industry. From April 1985 to December 1985, Mr. Levinson was the principal optical scientist at Raychem Corporation, and from January 1986 to February
1988, he was Optical Department Manager at Raynet, Inc., a fiber optic systems company. Mr. Levinson holds a B.S. in Mathematics/Physics from Butler University and an M.S. and Ph.D. in Astronomy from the University of
Ken Wilcox is president and CEO of SVB Financial Group. Since January 2000, when he took on the role, Wilcox has successfully pursued a strategy of expansion and diversification, while remaining focused on the company's
core niches of technology, life sciences, private equity and premium wineries. Wilcox joined Silicon Valley Bank in 1990 when he co-founded the company's East Coast Technology Division. In this role, Wilcox managed the first regional
office of Silicon Valley Bank and was responsible for all lending activity east of the Mississippi River. Upon promotion to chief banking officer in 1997, Wilcox moved from Massachusetts to California and became president and CEO within
four years. Prior to joining Silicon Valley Bank, Wilcox spent two years as a member of the Technology Lending Group with the Bank of New England and five years at Shawmut Bank in Boston. Prior to his banking career, Wilcox was a professor
of German at The University of North Carolina at Chapel Hill. Wilcox received a bachelor's degree in German studies from Oakland University and a Ph.D. in German Studies from The Ohio State University. He also earned a master's of business
administration from Harvard Business School. Wilcox is a member of the board of directors of the Federal Reserve Bank of San Francisco and the Silicon Valley Leadership Group.
Jesse Fink is a founding partner of MissionPoint Capital and President and CEO of Marshall Street Management. In 2004, MSM established MSM Capital Partners to manage its investment activities in the clean technology and
environmental finance sectors. Jesse was the COO of Walker Digital Inc. and Priceline.com and previously worked at Georgia-Pacific, Citicorp, and CUC International. Jesse received a B.S. in Resource Management from the State University of
New York's College of Environmental Science and Forestry and an MBA from Syracuse University's School of Management. In February of 2007, Jesse received the Cleantech Venture Network's "Leader of the Year" award.
Mike Maples, Jr. is the managing partner of Maples Investments, and is an entrepreneur in his own right. Before becoming a full-time investor, he worked in a variety of executive and management roles in high-growth
companies. His background spans a variety of markets including consumer technology, small business, and the enterprise, and he has served in various executive roles in product development, marketing, and corporate strategy. Mike began his
technology career in high school, when he started a software company that developed games and educational products for the original IBM PC. He has been passionate about the technology industry ever since. Most recently, Mike co-founded
Motive, Inc., the world's leading broadband software company in 1997 and played key roles in its growth from raw start-up through sales of $100 million. Motive was one of the only successful technology IPOs in 2004, and the most successful
infrastructure software IPO for the prior three years. At Motive, Mike was General Manager of Motive's Corporate Business Unit, as well as Chief Marketing and Strategy officer. Prior to Motive, Mike was responsible for worldwide product
marketing at Tivoli Systems, where he managed the company's product portfolio from its early-stage development through its 1995 IPO and growth to a $750M line of business within the IBM Software Group. Mike began his professional career at
Silicon Graphics, where he served in business development and product marketing roles. In his spare time Mike is an amateur artist, movie-maker, and calligrapher. He holds an Engineering degree from Stanford University, an MBA from Harvard
Business School, and is a frequent speaker at industry conferences and a guest-lecturer on entrepreneurship at Harvard Business School, Stanford University, Princeton University, and the University of Texas.
Mitch Kapor has been at the forefront of the information technology revolution for a generation as an entrepreneur, investor, social activist, and philanthropist. Most recently, Mr. Kapor founded Foxmarks, an upcoming
search engine based on bookmarks and related metadata. He received a B.A. from Yale College in 1971 and studied psychology, linguistics, and computer science as part of a major in Cybernetics. He attended the Sloan School of Management at
MIT before leaving for a Silicon Valley startup. Mr. Kapor founded Lotus Development Corp. in 1982 and with Jonathan Sachs created Lotus 1-2-3, which made the PC ubiquitous in business in the 1980's. In 1990, he co-founded the Electronic
Frontier Foundation. He founded the Mitchell Kapor Foundation in 1997 and the Open Source Applications Foundation in 2001. He became the founding Chair of the Mozilla Foundation in 2003 and is a trustee of the Level Playing Field
Institute. From 1994-1996, he served as Adjunct Professor at the MIT Media Lab. From 1999 to 2001, Mr. Kapor was a partner at Accel. In 2006, he became an Adjunct Professor at the School of Information at Berkeley. Mr. Kapor has
contributed pieces on information infrastructure policy, intellectual property, and antitrust in the digital era topublications such as Scientific American, The New York Times, and Forbes.
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William Ritchie Sorley
William Ritchie Sorley (/ˈsɔrli/; 4 November 1855 – 28 July 1935) was a Scottish philosopher. A Gifford Lecturer, he was one of the British Idealist school of thinkers, with interests in ethics.
William Ritchie Sorley was born in Selkirk, the son of Anna Ritchie and William Sorley, a Free Church of Scotland minister. He was educated at Edinburgh University and Trinity College, Cambridge.[1] He was Knightbridge Professor of Philosophy in the University of Cambridge from 1900 until 1933. He died, aged 79, at Cambridge.
He is now remembered for his A History of British Philosophy to 1900, published in 1920, with its idiosyncratic slant, as a retrospective view from the point of view of British Idealism. Among his other published works are: The Ethics of Naturalism: a Criticism (second edition 1904), The Moral Life and Moral Worth (1911), and his Gifford Lectures Moral Values and the Idea of God (second edition 1921). The poet Charles Sorley was his son.
- ^ "Sorley, William Ritchie (SRLY880WR)". A Cambridge Alumni Database. University of Cambridge.
External links[edit]
- Works written by or about William Ritchie Sorley at Wikisource
- Works by William Ritchie Sorley at Project Gutenberg
- Works by or about William Ritchie Sorley at Internet Archive
- William Ritchie Sorley some biographical notes and Lectures available from the Gifford Lectures website
|This biography of a Scottish academic is a stub. You can help Wikipedia by expanding it.
|This biography of a British philosopher is a stub. You can help Wikipedia by expanding it.
- 1855 births
- 1935 deaths
- Alumni of the University of Edinburgh
- Academics of the University of Cambridge
- Scottish philosophers
- Scottish theologians
- Scottish historians
- People from Selkirk, Scottish Borders
- 19th-century Scottish people
- Humboldt University of Berlin alumni
- Academics of Cardiff University
- Academics of the University of Aberdeen
- Alumni of Trinity College, Cambridge
- Scottish academic biography stubs
- British philosopher stubs


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Qualcomm fights analog cutoff delay
Company's mobile TV service waiting
While Qualcomm officials have never publicly said they were dissatisfied with MediaFLO's early years, the company on Thursday replaced Gina Lombardi as president of FLO TV. It named outsider Bill Stone as senior vice president and president of FLO TV. Stone has worked for wireless carriers including Vodafone, Verizon and Amp'd Mobile and most recently was chief executive of mobile-content company Handango.
MediaFLO has been hampered by the remaining Channel 55 broadcasters, which has delayed the national marketing that could make it a viable service, In-Stat analyst Michelle Abraham said.
While Qualcomm has a head start, there are competing technologies that are not far behind, Abraham said. Broadcasters are developing a version of their digital signals that will work on a moving device.
A delay would take away some of Qualcomm's lead, she said.
A bigger problem is that mobile TV is an optional service, and many consumers may think twice these days before spending an additional $15 a month, Abraham said.
"They've got the clouds of the economy hanging over them," she said.
Qualcomm's mobile TV service offers 15 channels of broadcast programming on the same frequency that previously carried one analog station. It requires a compatible phone. There are currently seven MediaFLO phones available, four from AT&T and three from Verizon.
More phones are expected in the next six months.
Qualcomm has 100 Media-FLO transmitters ready to be turned on and says it stands to lose "tens of millions of dollars" if the transition is pushed back four months, Chief Operating Officer Len Lauer said.
"We have very much complied with the laws and guidelines set by Congress and the FCC," Lauer said. "We believe they need to hold to the date we've been promised."
Jonathan Sidener: (619) 293-1239; email@example.com


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Smoked Brie
- Total Time:
- 2 hr
- Prep:
- 20 min
- Inactive:
- 1 hr 10 min
- Cook:
- 30 min
- Yield:
- 6 to 8 servings
- Level:
- Intermediate
- Total Time:
- 2 hr
- Prep:
- 20 min
- Inactive:
- 1 hr 10 min
- Cook:
- 30 min
- Yield:
- 6 to 8 servings
- Level:
- Intermediate
- Extra-virgin olive oil, for brushing
- 1 small wheel brie or Camembert cheese
- 2 fresh bay leaves or 2 sprigs fresh thyme
- You'll also need:
- 2 cups hickory, cherrywood or applewood chips
- 1 large piece cheesecloth
- Kitchen twine
- 1 9 -inch-round disposable aluminum pie pan
- Soak the wood chips in water 1 hour, then prepare your grill for smoking.
Lay out the cheesecloth on a work surface and brush with olive oil. Place the cheese in the middle and top with the bay leaves. Wrap the cheesecloth tightly around the cheese and tie closed with kitchen twine. Set the cheese, herb-side up, in the disposable pie pan.
Once the grill reaches 250 degrees F, place the pan with the cheese on the cooler side of the grill. Close the grill and let smoke until slightly golden, about 20 minutes. If using a gas grill, turn off the flame and let the cheese sit, covered, 10 more minutes (this is not necessary if using charcoal; it imparts more smoky flavor). Remove from the grill and unwrap.
3 More Types of Cheese to Try
Halloumi: One 8-ounce piece, brushed with olive oil
Ricotta: 1/2 pound fresh(do not wrap in cheesecloth)
Feta: One 8-ounce piece, brushed with olive oil
Recipe courtesy of Food Network Magazine
Cooking Tips
More Recipes and Ideas
Pate Bites and Herb Brie Board
Recipe courtesy of Rachael Ray
French Poodles
Recipe courtesy of Food Network Kitchen


text:
Hang tight!
Recipe by mythreesonsnh
"Chicken, broccoli, and stuffing casserole."
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3 cups
prepared stuffing
2 cups
cubed cooked chicken
2 cups
broccoli florets
1 (12 ounce) jar
chicken gravy
1 cup
shredded Cheddar cheese, divided
This is one of my go-to recipes. If I am low on cash and do not have cheese, I skip it all together. I sprinkle the stuffing mix over the top and drizzle butter over the stuffing before baking. This is also great for after Thanksgiving--just use leftover turkey, whatever vegetables you have left over, leftover gravy and you can even add a layer of mashed potatoes. VERY filling. This is one of my husband's favorite meals.
My family did not like this. Not great.
15 Ratings
I knew we would 'like' this b/c we like everything in it, but it went beyond like, we absolutely LOVED it! This could not have been easier to prepare, but the end results seemed like it too a lot of effort. I served it w/ mashed potatoes, extra gravy and cranberry sauce. With the cooler temps approaching, this will be a staple. This is awesome comfort food...a definite keeper~YUM Thanks for sharing. :)
Quick & easy. We liked it.
Really? How does this recipe not have MORE reviews? And BETTER reviews? My husband and I LOVE this dish! Such a quick and easy recipe for some good "comfort food". I always have chicken pre-cooked and shredded in my freezer, so it takes no time at all to assemble this. I fix this about twice a month during the colder months, and have always prepared it exactly as the recipe is written. I stretch the baking time 30 - 35 minutes and enjoy the occasional bite with the slightest hint of "crunch". Yum!
I gave this recipe 5 stars for easy prep & good eating . Have made it quite often & always get great reviews from all !!!!!!!!!!
Good tasting,easy to prepare. Did not have chicken gravy on hand so I had to use Cream of Chicken soup and some chicken broth. I also added fresh mushrooms. Everyone loved it. I will be fixing this again and maybe change it up a little!!!
This was lovely all the family enjoyed this very tasty added carrots to this!
* Percent Daily Values are based on a 2,000 calorie diet.
Quick Chicken and Stuffing Casserole
Serving Size: 1/4 of a recipe
Servings Per Recipe: 4
Amount Per Serving
Calories: 594
Calories from Fat: 286
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See how to make a super-simple, comforting winter casserole.


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ApplianceGeneral Electric Range
Level of DifficultyReally easy
Time to do repairLess than 15 mins
Age of Appliance5 - 10 years
0 out of 1 people found this instruction helpful
I took the old cap off, and replaced it with the new one. I am glad I had the sense to buy this online, If I had gotten a repairman to fix this, it probably would have costs $100.00 instead of the $17.00 it cost me to fix it myself. Thanks.
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I hav just been across to our local (ish) big out of town M&S and Tesco - mainly to go to an optician appointment at the Tesco. You couldn't get near the place! All access roads were jammed - I eventually got in and drove around the car park for 40 minutes following the parade of cars in front of me, I phoned the optician from outside the shop and cancelled the appointment and drove home. It was complete chaos! I have been on sale days, Christmas Eve etc but have never seen anything like this!
Think I will have a look online now


text:
The Directorate General of Civil Aviation (DGCA) on Wednesday dismissed all objections for granting air operator's permit (AOP) to Tata-Singapore Airlines (SIA).
The 51:49 joint venture between Tata Sons and SIA is expected to begin its operations by September/October. The JV got an approval from the Foreign Investment Promotion Board (FIPB) in October last year, and is awaiting AOP for launching a full-service carrier.
As per the provision of Aircraft Rules, a public notice was issued in May by DGCA, inviting objections/suggestions from public regarding the grant of permit to Tata-SIA.
DGCA in a notice on Wednesday said, "A total of six representations were received through email/in writing, which included representations submitted by the Federation of Indian Airlines (FIA) and Mr Jain objecting the grant of AOP."
As per the notice, the objections were raised on issues pertaining to: "FDI is not permitted in greenfield airlines as per the applicable FDI Policy as the said policy was devised to inject funds in the 'existing' cash starved domestic airline companies" and "the substantial ownership and effective control does not vest in Indian nationals which is a fundamental requirement of the Schedule XI of the Aircraft Rules which also raises a grave question in relation to matters of security".
The issue related to allowing FDI by foreign airlines in the greenfield airlines is challenged by the FIA in the Delhi High Court, which is sub-judice.
"After the detailed examination of objections/issues raised in the representations, the response of Tata-SIA, and various rules and other provisions for issuance of AOP, I am of the view that the representationists have not been able to make out any case against Tata SIA Airlines Ltd, for refusing to consider its application for the grant of AOP (scheduled)," said the DGCA notice.
Tata-SIA is already gearing up for its entry into Indian skies with plans to start the operations by September this year, subject to the grant of AOP. The airline currently is in the process of hiring pilots, cabin crew and engineering personnel.


text:
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