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Featured AffiliateECOreport
Top Stories
Global Warming Fight To Get Harder from 2012, Says U.N.
November 25, 2004 12:00 AM - Alister Doyle, Reuters
Fighting global warming will get tougher once the Kyoto protocol ends in 2012 and the world must try to get Washington involved in the long term, the head of the U.N. Environment Programme said on Wednesday.
Aborigines Hope Camel Exports Will End Poverty
November 25, 2004 12:00 AM - Kylie Stott, Reuters
A group of Aborigines shelter from the blazing outback sun beneath a large desert oak, sipping strong bush tea and hungrily eyeing the camel meat burgers sizzling on the camp grill.
World Conservation Union Says Bangkok Talks Boost Nature Protection Efforts
November 25, 2004 12:00 AM - Daniel Lovering, Associated Press
Scientists and officials strengthened efforts to forestall the extinction of thousands of species and protect the world's habitats in talks in Bangkok, but governments need to work harder to promote conservation, an international environment agency said Thursday.
Automakers May Feel Pressure by CalPERS to Improve Emissions
November 25, 2004 12:00 AM - Alexa H. Bluth, The Sacramento Bee
California State Controller Steve Westly and CalPERS board member Sean Harrigan want the state's pension fund to lean on automakers to comply with ground-breaking new standards adopted by the state Air Resources Board to help curb global warming.
Ontario Plans Renewable Energy for 100,000 Homes
November 25, 2004 12:00 AM - Reuters
Ontario plans 10 new energy projects that could supply power to 100,000 homes from renewable sources like wind, hydro and landfill biogas, the provincial government said Wednesday.
Maryland Governor's List of Surplus Property Alarms Environmentalists, Legislators
November 25, 2004 12:00 AM - Gretchen Parker, Associated Press
Gov. Robert Ehrlich wants to sell off land, buildings and other surplus state property in a plan that has alarmed environmentalists and led to a feud with Maryland's biggest and most influential newspaper, The (Baltimore) Sun.
Flame Retardant PBDE Found in Lake Michigan, Adding to Concerns
November 25, 2004 12:00 AM - John Heilprin, Associated Press
Concentrations of a flame retardant banned by many European countries have been found in Lake Michigan and are increasing, adding to concerns over previous findings that the chemicals were showing up in supermarket foods and women's breast milk.
Land Adjacent to California's Yosemite Park Bought by Conservation Group
November 25, 2004 12:00 AM - Paul Rogers, San Jose Mercury News
A picturesque landscape of sugar pine, incense cedar and white fir trees adjacent to Yosemite National Park's western boundary near El Portal will be protected from development under a deal announced Monday.
Groups Join, Seek Action on Global Warming
November 24, 2004 12:00 AM - Glenn Adams, Associated Press
More than a dozen conservation and public health advocacy groups joined on Tuesday to throw their collective support behind further legislative action to prevent global warming.
Montenegro's Parliament Mulls Government Plans to Flood Europe's Deepest Canyon
November 24, 2004 12:00 AM - Predrag Milic, Associated Press
Montenegro's parliament opened a debate Tuesday on a contentious government plan to build a huge dam that would flood the Tara Canyon, a popular tourist destination that is part of a UNESCO world heritage site.


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Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo
- Equal contributors
1 Institute for Cancer Genetics, Columbia University, New York, NY, USA
2 Center for Computational Biology and Bioinformatics, Columbia University, New York, NY, USA
3 Department of Pathology and Cell Biology, Columbia University, New York, NY, USA
4 Department of Surgery, Columbia University, New York, NY, USA
5 Department of Pediatrics, Columbia University, New York, NY, USA
6 Department of Electrical Engineering, Columbia University, New York, NY, USA
BMC Cancer 2011, 11:529 doi:10.1186/1471-2407-11-529Published: 30 December 2011
The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT).
We used xenograft models of human cancer cells in immunocompromised mice, profiling the harvested tumors separately with species-specific probes and computationally analyzing the results.
Here we show that human cancer cells express in vivo a precise multi-cancer invasion-associated gene expression signature that prominently includes many EMT markers, among them the transcription factor Slug, fibronectin, and α-SMA. We found that human, but not mouse, cells express the signature and Slug is the only upregulated EMT-inducing transcription factor. The signature is also present in samples from many publicly available cancer gene expression datasets, suggesting that it is produced by the cancer cells themselves in multiple cancer types, including nonepithelial cancers such as neuroblastoma. Furthermore, we found that the presence of the signature in human xenografted cells was associated with a downregulation of adipocyte markers in the mouse tissue adjacent to the invasive tumor, suggesting that the signature is triggered by contextual microenvironmental interactions when the cancer cells encounter adipocytes, as previously reported.
The known, precise and consistent gene composition of this cancer mesenchymal transition signature, particularly when combined with simultaneous analysis of the adjacent microenvironment, provides unique opportunities for shedding light on the underlying mechanisms of cancer invasiveness as well as identifying potential diagnostic markers and targets for metastasis-inhibiting therapeutics.

subset: commoncrawl


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VTrckS Technical Setup for Awardees
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It is important to confirm the technical setup for any user accessing VTrckS by running the PC Readiness Tool. The PC Readiness Tool is located on the SAMS home page under "My Applications." Clicking the link will provide access to the tool and the appropriate user guide to walk through the process.
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50th Annual Western & Heritage Art Show
Alamo Kiwanis Club Charities, Inc., San Antonio, TX
Friday, January 18, 2013 from 6:30 PM to 10:30 PM (CST)
San Antonio, TX
Contact the Host
When & Where
Pearl Studio
200 E. Grayson
San Antonio,
Friday, January 18, 2013 from 6:30 PM to 10:30 PM (CST)
Add to my calendar
Alamo Kiwanis Club Charities, Inc., San Antonio, TX
The Alamo Kiwanis Club reflects the purpose of Kiwanis International:
To help children.
The volunteer-run non-profit organization has approximately 100 community members and meets weekly. The Alamo Kiwanis Club produces two major fundraisers each year to benefit local children's charities: The Western Heritage Art Show and Fiesta Noche del Rio. More than $2.5 million has been raised from these two annual events to date!
For more information or to learn how you can become a member, please call 210-226-4651 or visit www.alamo-kiwanis.org.


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"Content Deleted"
New skill trees with 210 new skills, new base items, gems, runes, uniques, runewords, sets, crafting improved monster AI and new monster types, elite and heroic monsters, 28 uberquests for advanced characters, 5 challenges. Compatible with Diablo II Lord of Destruction 1.10/1.11/1.12/1.13 (PC/Mac).
Median XL 1.F9h for Diablo II Lord of Destruction 1.10/1.11/1.12/1.13 (PC/Mac)
>>> Median XL 1.F9h
for Diablo II Lord of Destruction 1.10/1.11/1.12/1.13
Mods by Brother Laz
Details can be found on the ModDB page or on the official website. Enjoy!
"Content Deleted"
how too i keep the normal diablo 2 lod aswell as the mod
is this mod any god for single player?
Yes, after all...it is a single player mod. It is playable online, through Open Battle.net or other methods (Hamachi).
i like single player i have a char level 84 on 1.13 patch single player
going to star xl soon
does plugy work with this?
in future uploads, will you be at all uploading full documentation with the mod for players that play offline only?
Why don't you just download the website? :P Html doesn't lend itself very well for offline docs.
Since 2002 we have explored, played and enjoyed mods of all shapes and sizes just like Median XL. We love games like Diablo II: Lord of Destruction that have opened themselves up to modding. Because of communities like Steam Workshop, Nexus, Curse, RTSL, GameBanana and Mod DB, more games support modding today than ever before.
Whether it is for fun, for laughs or for the challenge, modding is what sets PC gaming apart from our closed off friends in the console and mobile gaming worlds. And based on the recent outpouring of support for mods after the concept of paid modding was explored, we are not alone in our love for mods and open platforms that embrace them.
As mods play a bigger role in the future of gaming, we believe it is important to recognize the effort the teams behind the work put in, giving us countless hours of enjoyment while asking nothing in return. We have the power to change our games and that needs to be celebrated to ensure it remains a big part of PC gaming's future.
Nothing is more motivating than knowing something you've built kicks-ass. So this week if there is a mod you love on Mod DB (or anywhere else), make the effort to shout out to them, mention and link their mod in a tweet, blog, forum or facebook post with the hashtag #modlove2015 (or click the icons above for a pre-built post).
To thank those who participate in spreading the love and awareness, we have partnered up with many awesome mod-friendly games (Killing Floor 2, Mount & Blade Warband, Space Engineers, Insurgency, Chivalry: Medieval Warfare, Black Mesa, Contagion, Amnesia - get involved) & have hundreds of keys to giveaway. To win one of the games, after you have linked to a mod on Mod DB (or anywhere else) in a tweet, blog, forum or facebook post, let us know by leaving a comment with a link to your post. At the end of the week we shall be picking members at random who followed these rules, and will send them a key from one of these games.
Your comment "+currentoption.html().toLowerCase()+" was successful. When a comment is deleted all replies to the comment will be removed as well. Because you are an admin, you can click the \"view deleted\" link above to view deleted comments in-case you wish to un-delete them in the future. If this was a mistake, click the "+currentoption.html().toLowerCase()+" link again to reverse the change." : "
"+response["text"]+""); currentoption.html(response["labels"]["delete"]); }; $(".tablecomments .delete").saveUpdate("delete", deleteAction); $("#commentpreview").click(function() { $(this).formPreview("/profile/ajax/preview/comment", $("#commentpreviewarea"), $("#commentsummary").val()); return false; }); $("#commentemail").after(''); $("#mods5960watch").saveUpdate("watch"); $("#mods5960report").saveUpdate("report"); $("#watchtoggle").saveUpdate("watch"); $("#reportdownload").saveUpdate("report"); if(measureWidth("div.footermediabox div.media") > 728) { $("div.footermediabox").addClass("footermediaboxwide"); } if(typeof isAB === "undefined") { yesAB(); } else { isAB.on(true, yesAB).onNotDetected(noAB); } function yesAB() { ga("send", "event", "Adblock", "Blocked", "true", 1); $("div.mediabox div.media").html("