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Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial
- M. M. Joosten,
- J. W. J. Beulens,
- S. Kersten,
- H. F. J. Hendriks
- … show all 4 hide
To determine whether 6 weeks of daily, moderate alcohol consumption increases expression of the gene encoding adiponectin (ADIPOQ) and plasma levels of the protein, and improves insulin sensitivity in postmenopausal women.
In a randomised, open-label, crossover trial conducted in the Netherlands, 36 apparently healthy postmenopausal women who were habitual alcohol consumers, received 250 ml white wine (∼25 g alcohol/day) or 250 ml of white grape juice (control) daily during dinner for 6 weeks. Randomisation to treatment allocation occurred according to BMI. Insulin sensitivity and ADIPOQ mRNA and plasma adiponectin levels were measured at the end of both periods. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Levels of ADIPOQ mRNA in subcutaneous adipose tissue were determined by RT-PCR.
All subjects completed the study. Six weeks of white wine consumption reduced fasting insulin (mean ± SEM 40.0 ± 3.4 vs 46.5 ± 3.4 pmol/l; p < 0.01) and HOMA-IR (1.42 ± 0.13 vs 1.64 ± 0.13; p = 0.02) compared with 6 weeks of grape juice consumption. ADIPOQ mRNA levels (1.09 ± 0.15 vs 0.98 ± 0.15; p = 0.04) and plasma levels of total (13.1 ± 0.8 vs 12.0 ± 0.8 μg/ml; p < 0.001) and high molecular weight (HMW) adiponectin (9.9 ± 1.2 vs 8.8 ± 1.2 μg/ml; p = 0.02) significantly increased after alcohol compared with juice consumption. Changes in ADIPOQ mRNA levels correlated with changes in plasma levels of total adiponectin (ρ = 0.46; p < 0.01). Both fasting triacylglycerol (8.2%; p = 0.04) and LDL-cholesterol levels (7.8%; p < 0.0001) decreased, whereas HDL-cholesterol increased (7.0%; p < 0.0001) after prolonged moderate alcohol intake. No notable adverse effects were reported.
Moderate alcohol consumption for 6 weeks improves insulin sensitivity, adiponectin levels and lipid profile in postmenopausal women. Furthermore, these data suggest a transcriptional mechanism leading to the alcohol-induced increase in adiponectin plasma levels.
Trial registration:
ClinicalTrials.gov ID no.: NCT00285909
Partly funded by the Dutch Foundation for Alcohol Research (SAR).
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- Koppes, LLJ, Dekker, JM, Hendriks, HFJ, Bouter, LM, Heine, RJ (2005) Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care 28: pp. 719-725 CrossRef
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- Zilkens, RR, Burke, V, Watts, G, Beilin, LJ, Puddey, IB (2003) The effect of alcohol intake on insulin sensitivity in men: a randomized controlled trial. Diabetes Care 26: pp. 608-612 CrossRef
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- Gonzalez-Ortiz, M, Pascoe-Gonzalez, S, Kam-Ramos, AM, Martinez-Abundis, E (2005) Effect of tequila on homocysteine, insulin secretion, insulin sensitivity, and metabolic profile in healthy men. J Diabetes Complicat 19: pp. 155-159 CrossRef
- Chandran, M, Phillips, SA, Ciaraldi, T, Henry, RR (2003) Adiponectin: more than just another fat cell hormone?. Diabetes Care 26: pp. 2442-2450 CrossRef
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- Snehalatha, C, Mukesh, B, Simon, M, Viswanathan, V, Haffner, SM, Ramachandran, A (2003) Plasma adiponectin is an independent predictor of type 2 diabetes in Asian Indians. Diabetes Care 26: pp. 3226-3229 CrossRef
- Duncan, BB, Schmidt, MI, Pankow, JS (2004) Adiponectin and the development of type 2 diabetes: the Atherosclerosis Risk in Communities Study. Diabetes 53: pp. 2473-2478 CrossRef
- Thamer, C, Haap, M, Fritsche, A, Haering, H, Stumvoll, M (2004) Relationship between moderate alcohol consumption and adiponectin and insulin sensitivity in a large heterogeneous population. Diabetes Care 27: pp. 1240 CrossRef
- Englund Ogge, L, Brohall, G, Behre, CJ, Schmidt, C, Fagerberg, B (2006) Alcohol consumption in relation to metabolic regulation, inflammation, and adiponectin in 64-year-old Caucasian women: a population-based study with a focus on impaired glucose regulation. Diabetes Care 29: pp. 908-913 CrossRef
- Iwaki, M, Matsuda, M, Maeda, N (2003) Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52: pp. 1655-1663 CrossRef
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- Marx, N, Bourcier, T, Sukhova, GK, Libby, P, Plutzky, J (1999) PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler Thromb Vasc Biol 19: pp. 546-551
- Hoiseth, G, Bernard, JP, Stephanson, N (2008) Comparison between the urinary alcohol markers EtG, EtS, and GTOL/5-HIAA in a controlled drinking experiment. Alcohol Alcohol 43: pp. 187-191
- Bottcher, M, Beck, O, Helander, A (2008) Evaluation of a new immunoassay for urinary ethyl glucuronide testing. Alcohol Alcohol 43: pp. 46-48
- Joosen, AM, Bakker, AH, Zorenc, AH, Kersten, S, Schrauwen, P, Westerterp, KR (2006) PPARgamma activity in subcutaneous abdominal fat tissue and fat mass gain during short-term overfeeding. Int J Obes (Lond) 30: pp. 302-307 CrossRef
- Arvidsson, E, Viguerie, N, Andersson, I, Verdich, C, Langin, D, Arner, P (2004) Effects of different hypocaloric diets on protein secretion from adipose tissue of obese women. Diabetes 53: pp. 1966-1971 CrossRef
- Hernandez-Morante, JJ, Milagro, F, Gabaldon, JA, Martinez, JA, Zamora, S, Garaulet, M (2006) Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans. Eur J Endocrinol 155: pp. 593-600 CrossRef
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- Shai, I, Wainstein, J, Harman-Boehm, I (2007) Glycemic effects of moderate alcohol intake among patients with type 2 diabetes: a multicenter, randomized, clinical intervention trial. Diabetes Care 30: pp. 3011-3016 CrossRef
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- Kern, PA, Gregorio, GB, Lu, T, Rassouli, N, Ranganathan, G (2003) Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-α expression. Diabetes 52: pp. 1779-1785 CrossRef
- Engeli, S, Feldpausch, M, Gorzelniak, K (2003) Association between adiponectin and mediators of inflammation in obese women. Diabetes 52: pp. 942-947 CrossRef
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- Wang, Y, Lam, KS, Yau, MH, Xu, A (2008) Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J 409: pp. 623-633 CrossRef
- Hara, K, Horikoshi, M, Yamauchi, T (2006) Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 29: pp. 1357-1362 CrossRef
- Bobbert, T, Rochlitz, H, Wegewitz, U (2005) Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes 54: pp. 2712-2719 CrossRef
- Bluher, M, Brennan, AM, Kelesidis, T (2007) Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care 30: pp. 280-285 CrossRef
- Ouchi, N, Walsh, K (2007) Adiponectin as an anti-inflammatory factor. Clin Chim Acta 380: pp. 24-30 CrossRef
- Hung J, McQuillan BM, Thompson PL, Beilby JP (2008) Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity. Int J Obes (Lond) DOI 10.1038/sj.ijo.0803793
- Wellen, KE, Hotamisligil, GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115: pp. 1111-1119
- American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. World Cancer Research Fund (WCRF) American Institute for Cancer Research (AICR), Washington DC
- Title
- Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Journal
Volume 51, Issue 8 , pp 1375-1381
- Cover Date
- 2008-08-01
- 10.1007/s00125-008-1031-y
- Print ISSN
- Online ISSN
- 1432-0428
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
- Adiponectin
- Alcohol consumption
- Gene expression
- High molecular weight adiponectin
- Insulin sensitivity
- Lipid profile
- Peroxisome proliferator-activated receptor gamma
- Postmenopausal women
- Industry Sectors
- Authors
- M. M. Joosten (1) (2)
- J. W. J. Beulens (1) (2)
- S. Kersten (2)
- H. F. J. Hendriks (1)
- Author Affiliations
- 1. Business Unit Biosciences, TNO Quality of Life, P. O. Box 360, 3700 AJ, Zeist, the Netherlands
- 2. Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands


text:
Search the Collection
Nathaniel Hone (1718-1784), Portrait and miniature painter
Sitter in 9 portraits
Artist associated with 56 portraits
Hone was a Dublin-born portrait painter, miniaturist and engraver. He moved to England as a youth and worked as a travelling portrait painter. In 1742 he married the wealthy Mary Earle in York Minster. The couple moved to London where Hone established himself painting portraits and narrative scenes. In 1768, he became a founder member of the Royal Academy of Arts.
Related People
- Horace Hone (son)
- John Camillus Hone (son)

subset: commoncrawl


text:
Classicsonline Home » Artists » » Wright, Simon
Born in Sunderland, Simon Wright was educated at Chetham's School, Manchester and at the Royal Manchester
College of Music. A regular accompanist of the Hallé Choir, often working with Sir John Barbirolli, he won a
scholarship to the Royal Manchester College at the age of sixteen. Four years later he was appointed Organist of
the Benedictine foundation at Ampleforth Abbey in North Yorkshire, a post which he relinquished in the summer
of 2005. As a conductor Simon Wright has earned universal respect and acclaim. Throughout his career, which also
embraces rôles as organist, accompanist, arranger and teacher, he has become established as a musician of enormous
integrity, winning the admiration of musicians, audiences and critics alike. He has conducted many British
orchestras including the Philharmonia, the City of Birmingham Symphony Orchestra,at the age of sixteen
Philharmonic, BBC Scottish Symphony Orchestra, Royal Liverpool Philharmonic, English Northern Philharmonia,
English Chamber Orchestra, Northern Sinfonia, Manchester Camerata and Northern Chamber Orchestra. A prizewinner
in the 1986 Leeds Conducting Competition, he has been Conductor and Artistic Adviser of the Leeds
Festival Chorus since 1975 and Musical Director and Principal Conductor of the York Guildhall Orchestra since
1992. Deeply committed to the music of the twentieth and 21st centuries, he has conducted many orchestral and
choral premières including Dominic Muldowney's The Fall of Jerusalem, the British


text:
Investment Management Update - January 2015
Investment Management Update – Fees and Expenses
Investment Management Update- 2014 Election Impact
Investment Management Update - Focus on Data Privacy and Cybersecurity
Thomson Reuters Session 2: Investment Management, Hedge Funds and Registered Mutual Funds: What's Happening Now?
Stealth Lawyer: Eli Broverman, Financial Startup Co-Founder
Asset managers are increasingly looking to Australia as a source of growth and as a gateway to the Asia Pacific region. This overview will assist managers navigate the Australian regulatory landscape.
Financial Services...more
Sign up for your custom alerts now, using LinkedIn ›
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text:
6 posts tagged with youtube and education.
Displaying 1 through 6 of 6. Subscribe:
Spoken word for kids?
Favorite spoken words/performed poems for kids? [more inside]
I want to know more things in fun ways.
I'm looking for fun educational youtube videos. [more inside]
How can I download a Mythbusters clip from YouTube?
Where can I get a clip from a specific Mythbusters episode to use for a third grade class on the scientific method? [more inside]
Looking for ideas for a presentation on Web 2.0 and new web apps for teachers
What should I include in a presentation about new internet technology and digital media in the classroom to a group of high school teachers? [more inside]
'Tube Me!
Help me find a video on the changing nature of education and students. [more inside]
Web 2.0 in Higher Education
I'm looking for examples of Web 2.0 principles and tools being used in higher education. [more inside]
Page: 1


text:
"While were shooting we read a tabloid blog post that said Vanessa looked like a white-trash paint-huffing girl," said Bivens.
1831, originally Southern U.S. black slang.
The slaves themselves entertain the very highest contempt for white servants, whom they designate as 'poor white trash.' [Fanny Kemble, journal, Jan. 6, 1833]
(also white-shoe) Having the attitudes, appearance, etc, of the Ivy League: Do I look white shoe?/ a Harvard-educated bluestocking who practiced white-shoe corporate lawnoun phrase
A typical Ivy League student
[1980s+; fr the white buckskin shoes that were part of that student's dress]


text:
|Table of Contents
|Vol. 83, No. 5-6, 2006
Issue release date: October 2006
|Section title: Original Paper
Effects of Estrogen and Related Agents upon Methamphetamine-Induced Neurotoxicity within an Impaired Nigrostriatal Dopaminergic System of Ovariectomized MiceLiu B.a, b · Dluzen D.E.a
aDepartment of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, USA; bCenter for New Drugs Evaluation, School of Pharmaceutical Sciences, Shandong University, Jinan, P.R. China
Published online: 11/13/2006
Issue release date: October 2006
Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: http://www.karger.com/NEN
Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 µg) with related agents – tamoxifen (TMX, 12.5 µg), testosterone (5 µg) and dehydroepiandrosterone (DHEA, 3 mg) in this paradigm. In experiment 1, ovariectomized mice received an initial treatment with MA. At 1 week after MA, mice were treated with EB, TMX, testosterone, DHEA or oil vehicle and 24 h later a second MA treatment. Striatal DA and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations in the MA-treated groups were decreased compared to the non-MA-treated control. Neither EB nor any of the other agents tested showed enhanced neurodegenerative or neuroprotective effects against a second MA invasion. To verify that estrogen was capable of showing a neuroprotective effect under a condition of two administrations of MA, in experiment 2, EB was administered either once or twice prior to each of the two MA treatments. EB treatment prior to the first MA invasion or first and second MA protected the NSDA system against DA and DOPAC depletion. These results imply that a lower dose of EB, TMX, testosterone and DHEA cannot exert neurodegenerative or neuroprotective effects in the impaired NSDA model. However, EB administered prior to the introduction of neurotoxicity can protect the NSDA system. This study may provide an understanding of the variations in results on the effects of estrogen upon the NSDA neurodegenerative disorder, Parkinson's disease.
© 2006 S. Karger AG, Basel
Dean Dluzen
Department of Anatomy, Northeastern Ohio Universities College of Medicine
4209 State Route 44, PO Box 95
Rootstown, OH 44272-0095 (USA)
Tel. +1 330 325 6300, Fax +1 330 325 5913, E-Mail email@example.com
Received: February 2, 2006
Accepted after revision: July 10, 2006
Published online: August 22, 2006
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 2, Number of References : 39
Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)
Vol. 83, No. 5-6, Year 2006 (Cover Date: October 2006)
Journal Editor: Millar, R. (Edinburgh)
ISSN: 0028–3835 (print), 1423–0194 (Online)
For additional information: http://www.karger.com/NEN
Published online: 11/13/2006
Issue release date: October 2006
Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: http://www.karger.com/NEN


text:
Twenty members of the Canisius College Class of 2015 will dedicate the next year to living simply, working for social justice and serving those who live on the margins of society.
Adam Zyglis '04 is recognized for his work as an editorial cartoonist
Research by Canisius Professor Shows Active Learning Improves Cognitive Learning in Active Adults
Canisius College is the recipient of a $10,000 grant from Honeywell Hometown Solutions, the company's corporate citizenship program.
Canisius College's Vice President for Student Affairs, Terri Mangione, PhD, named H. Wilson Johnson the new director of public safety. Johnson began work at Canisius College on May 1.


text:
Lots of talent, little game (matchplay)
Hey, how's it going everyone. I need all your help, seriously, in developing an effective game.
I've been told by many that I am very "talented" and have all the shots in the book by many. I have big serves, great groundstrokes, consistency and good footwork. Yet I manage to crash and burn in many of my matches because my mental game is quite crappy. I'm condescending, a quitter/tanker, etc. Really just a terrible person on the court.
I desperately want to make a change for the better, so maybe a little tips here and there will be well appreciated. Don't be afraid to get personal or make assumptions. I'm open to criticism. :)
How long have you been playing?
What do you rate yourself?
No clue what I would rate myself. But I'm much better than those that claim to be 4.0....
I'm guessing that you start to choke in games. I do that too. Try to think of games as just practice and they have no meaning. Play your own game as in focus on being consistent, 2 down the line 2 cross court and so on. If you make mistakes, let it go.
video please?
I'm in a similar boat, playing low/mid d3 tennis. Just to give some perspective, I have ok serves (95-105 flat/slice, generally can place), pretty good racquet head speed on groundies, but have low shot tolerance and have only started developing somewhat good volleys. Been playing for 5 years or so, would probably be upper 3.5/lowest of 4.0.
What I would suggest is to find a set of simple, achievable goals that you stick to for an extended period of match time, for example 3 games. Could be something like "deep to backhand" or even "2 feet over the net," but it has to be concrete and achievable. This is difficult if new to match play, since it's easy to lose focus and abandon rational decisions after a long point, especially one you lost. When playing extremely consistent players, I sometimes start trying to go for baseline winners or serve and volley on second serves for the first time in my life, etc. If you have it, suppress that urge.
Find someone who beats you with consistency, patience, and location using junk or pushing shots and then play them until you can beat them.
video or you are not talented :)
Just need more point playing experience. Hitting alone does no good for playing tennis in a competitive enviorment. You need to play sets and matches, and KEEP SCORE.
You also have to learn to lose, before you can learn to win.
First step is to acknowledge if you lose the other guy was better. As trivial as it sounds, I'm always amazed at how few believe this.
Imagine you are playing a match tonight against a opponent you've never played before. You know nothing about them. How do you approach the match?
Also, apart from mental, what is the major weakness in your game?
Tanking, throwing temper tantrums, and generally make an A-hole of yourself are defense mechanism. You don't want to lose so you pee-pee all over yourself publicly rather than lose with touch of dignity. My advice is to grow the F up. Your tennis match is not all that important. Someone's first child is important. A family member or close friend getting cancer is important. Your tennis match, even your university tennis match is not important.
If you cannot figure out a way to play with some degree of maturity, just stop playing so you don't ruin it for the rest of us.
Just make a conscious effort to be nice and gracious on court. Bestowing grace alleviates a whole host of attitude issues
What NTRP Rating are you? I have buckets of talent also and amazing hands and Im a pusher :)
When asked what was the most difficult thing, Thales replied, To know thyself.
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32 year old woman | Miami, FL, USA | Seeking men 29-40 in United States
Active within 24 hours
Pray to have eyes tht see the best in ppl, a heart tht forgives the worst, a mind tht forgets the bad & a soul that never loses faith in God
I'm very fun and outgoing but most of all I love new experiences !! I was born and raised in a the beautiful city of Miami where you meet beautiful people of every race !! So I'm at a point where traveling is a priority. I get along well with any/everyone but I'm looking for someone with ambition and substance bc in return that's what I'm about !! I love the beach so my ideal date would be a day at the beach ( I know) hey that's just who I am :)) or an arts festival !! Submitted from mobile
Book club , Coffee and conversation , Business networking , Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Playing sports , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Basketball, Bowling, Cycling, Dancing, Football, Swimming, Walking / Hiking
I exercise 1-2 times per week.
I like Birds, Dogs, Fish
I had a poodle for about 2 weeks and decided to give her to my grandmother ( ohh the responsibility) lol
Middle of the Road
I love to "people watch" so a good brunch spot with a great view is great" but I'm very simple I can appreciate any establishment that has an upbeat atmosphere and I can enjoy myself
I'm a bit old school I love TV Land lol my favs are The Cosby Show, Golden Girls, The Nanny, Three's Company and the list goes on !! Movies vary from Pretty Women to Takers and of course I like comedy ( including animated films) not hard to please
I love hanging out with my friends. I'm an event planner so I'm always looking for something to do !! I love networking and meeting new people. But at the top of the list I must say its reading & writing !!
I love reading !! The last book I read was Nikki Turner's sequel "project chick" it's not what you think (great read) and the trilogy to Hunger Games
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|What she is looking for
|5'2" (157cms)
|5'10" (177cms) to 6'11" (210cms)
|Body type:
|About average
|No preference
|No preference
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker, Moderately
|Self-Employed / Entrepreneur
|No preference
I'm a distributor in the beauty industry but event planning is one of the most exciting things on the list ( a women of many talents) hey.. Do what you love and love what you do right ?!?
|I'll tell you later
|No preference
|Never Married
|Never Married, Widow / Widower, Divorced
|Have kids:
|Yes, and they live at home (1)
|No preference
|Wants kids:
|Probably not
|No preference
|Black / African descent
|No preference
|Christian / Other
|Christian / Other
I'm a woman of God growing stronger in my faith daily !! I always say there is something about a praying man. But there is power in a praying women !!
|Associates degree
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


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Originally Posted by
I plan to captain 7.5 ladies combo in January 2013. Our 2012 team was very strong and missed Districts by an eyelash.
When new ratings come out this month, I expect almost all of my 20 ladies to be 4.0. Which means we cannot possibly have a 7.5 team with the current roster.
I am torn about how to handled this. My personal goal is to put together a strong team and make another run at Districts for 2013. I anticipate that by 2014 I will be ready to play and captain 8.5.
I see a few options.
The Cold-Hearted Option.
When new ratings come out, I just send a message to the team saying we have too many 4.0s and I can only take ten. Then invite ten 4.0s and set about finding ten 3.5s. I would not make decisions based solely on seniority. I would be looking for players who are strong players and who are easy to partner and easy to captain. There would be some very surprised and angry people left out in the cold.
The Consensus Option.
Send out an email telling the team the numbers problem. See what folks want to do and take it from there.
The Random Draw Option.
Put all of the 4.0 names in a hat and draw them into two piles. Recruit another person from the other pile to captain a second competing team. The issue here is that players are not chattel and some may not like their assigned team.
The Cut and Run Option.
I could just send out an email dissolving the team. Someone else can take over and assemble the roster however they like. I would not treat captaining like a jump ball, as there are a few folks who would make dreadful captains. I would hand it over to someone who knows how to captain.
Move Up To 8.5.
Declare that the team is moving up to 8.5 combo, and anyone who wants the challenge can have a go.
What have you other captains done? What works, and what doesn't work?
Options 2 and 3 are non-starters in my opinion.
Option 5 is independent of the others, since you could 'promote' the existing team to 8.5 and still field some variation of it as 7.5.
Option 4 is also somewhat independent. If you don't want to captain, don't captain. If you do want to captain, it solves nothing.
Option 1 is good, as long as you're up front with the existing team-members about what your intentions and goals are.
And then there's another option: You captain the team with a more social attitude. You take the players you get along with best, that have fun together, and that are easy to captain. Maybe not as strong a team as would result from option 1, but perhaps more enjoyable.
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Till a few years back, producer Ekta Kapoor was hailed as the undisputed soap queen of the small screen. Cut to now, thanks to her run-ins with the censor board of late, she now seems to have become the 'controversy queen' of the big screen!
But Ekta insists that she's always been that. "By now I'm pretty used to being dragged in one panga after another. My films like The Dirty Picture or Kya Super Kool Hain Hum facing censor trouble or other such issues may be new, but I have been courting trouble right from the time I set foot in the industry," she says referring to the flak she faced when changing gears on the small screen to shift focus onto saas-bahu sagas and kitchen politics. "I was accused about being regressive back then and God only knows what not. In fact, what I face today is nothing in comparison. It's far lesser now. But you choose what you do and I choose to walk my way. The success of these films only reinforces my faith," explains the producer as we catch up with her for a quick chat. Here Ekta also reveals her fears and talks about marriage…
Your films seem to be getting higher on sexual content. Sex sells?
No it's not just about that. Both my recent films are what I would call sexually liberating, though each in its own way. And it's nothing that we don't see around us. It's just that we've put it out on screen. We all laugh on adult and naughty jokes in real life, so why not laugh with onscreen characters?
You are one of the strongest players in Bollywood today, what's your take on competition?
I think it's fabulous and very healthy, the way it is at present. I mean we are competitors when it comes to business, but we are also friends. So we are supportive of each other and rooting for our films. We are more like allies than foes and definitely very respectful about each others work. I think the admiration comes out of respect. And personally you are not looking at beating the other filmmaker, but trying to better your own film, so it's positive.
Is there anything you fear?
I am paranoid and damn scared on the day my film's release. I had thought by the time I am few films old, the fear would subside. But n, I still get nervous.
Now that you have lost oodles of weight and looking rather fab yourself, how about acting?
No way. I am so not an actor! I can't face the camera, I start laughing the minute I do.
Not for now. I don't want to take that much on my platter.
What about marriage? Isn't there family pressure?
Well, I don't know if my family's talking about it. I am so busy that I hardly get to talk to them. So, I have no clue if they discuss my marriage. As for me, like I said, where is the time, yaar?`


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Professional Affiliations•The Fellows of the American Bar Foundation, Member
Michael Brophy is a seasoned trial attorney with more than 30 years of experience, and a partner at Goldberg Segalla. Working from the firm's Philadelphia, Pennsylvania office, Mike has developed a specialty in the defense of psychiatric malpractice cases as well as traditional medical malpractice litigation. He has been designated as lead trial counsel by health care organizations and automotive product manufacturers with both local and national affiliations. Mike's success rate exceeds 90 percent in more than 50 major cases he has taken to verdict. In addition to traditional activities, he has an active mediation practice and was a mediator in the United States District Court for the Eastern District of Pennsylvania from 1991 to 1996. More recently, Mike has been selected to serve as the sole arbitrator deciding cases filed in Philadelphia County, expediting the final disposition of these matters by several years and significantly reducing litigation costs for the parties. Mike has also served as a Judge Pro Tempore for the Court of Common Pleas from 2005 to the present.Mike is co-editor of Law Journal Newsletters' Medical Malpractice Law & Strategy, for which he has authored numerous articles. He is author of the textbook Medical Malpractice Depositions and is a frequent speaker at CLE seminars. Mike possesses an AV rating through Martindale-Hubbell.Court Appointments•Mediator, U.S. District Court, Eastern District of Pennsylvania (1991-1996) •Philadelphia County Court of Common Pleas, Judge Pro Tempore (2005-present)Honors•Martindale-Hubbell Peer Review Rating: AV Preeminent •Pennsylvania Super Lawyers, 2010-2014 (Personal Injury: General Defense)Prior Experience•Staff Attorney/Supervising Staff Attorney, U.S. Third Circuit Court of Appeals, Philadelphia, Pennsylvania, 1977-1981 •Law Clerk to the Honorable William W. Vogel, Montgomery County Court of Common Pleas, Norristown, Pennsylvania, 1976-1977Publications/Presentations:•Co-Author, "Concussion and Traumatic Brain Injury: An Historical Perspective," DRI The Voice, March 18, 2015•Author, "Florida's Statutory Cap on Non-Economic Damages Deemed Unconstitutional, Part II," Medical Malpractice Law & Strategy, June 2014•Author, "FL Supreme Court Overturns Statutory Cap on Non-Economic Damages, Part I," Medical Malpractice Law & Strategy, May 2014•Author, Medical Malpractice Depositions, Juris Publishing, 2004-2013•Co-Author, "The Duty to Notify an Excess Carrier: Considerations for Defense Counsel," Medical Malpractice Law & Strategy, March 2013•Presenter, Using Jury Selection To Increase Your Success At Trial, National Business Institute Seminar: Litigation to Win Through Advanced Trial Advocacy, August 2011•Co-Author, The Fundamentals of Mediation Practice: A Brief Refresher Course, ADR Choices, Defense Research Institute, June 2010 •Author, The International Community Weighs in on Expert Witness Immunity, Medical Malpractice Law & Strategy Newsletter, December 2008 •Presenter, Evidence and Expert Testimony Best Practices: Supporting Your Case, National Business Institute, December 2008 •Co-Author, Recovery for the Death of a Stillborn Child: A Journey through the Legal Process, Medical Malpractice Law & Strategy Newsletter, October 2008 •Presenter, Evidentiary Challenges to the Admissibility of Expert Testimony, National Business Institute Seminar: Evidence and Expert Testimony Best Practices-Supporting the Case, December 2007 •Presenter for numerous CLE presentations sponsored by Pennsylvania Bar Institute and National Business Institute •Author, Partial Birth Abortion: The Supreme Court's Ruling in Gonzales vs. Carhart, Medical Malpractice Law & Strategy Newsletter, June 2007 •Presenter, Grand Rounds, Thomas Jefferson University Hospital regarding Professional Liability - Psychiatrists 2004•Presenter, Emerging Trends in Psychiatric Malpractice, AHLA Seminar, New York, 2002 •Co-Editor, Law Journal Newsletter, Medical Malpractice Law and Strategy: •The Debate on Cardiac Stent Safety, December 2006 •The July 2006 IOM Report on Medication Errors, August 2006 •Physician-Assisted Suicide Passes Supreme Court Muster, March 2006 •Suits Against Healthcare Employers: Negligent Hiring, December 2005 •Confronting Medical Error, October 2005 •The Impact of Obesity in Healthcare Litigation: One Lawyer's Experience, April 2005 •Physician Apologies for Medical Errors, a Role in Risk Management? December 2004 •Multi-Million Dollar Verdicts: Time for a Second Opinion, two-part article published May and June 2004•Fear of Cancer: A Med Mal Nightmare? June 2003 •Federal Appellate Courts Interpret Patient Stabilization Requirement of EMTALA, two-part article published in December 2002 and January 2003 •Peer Review: Ruling May Signal New Chapter in Expert Testimony of Medical Society Members, May 2002 •Reconsidering the Results of National Medical Error Reporting, November 2001 •Emerging Medical-Legal Issues in the Prescriber-Patient Relationship, June 2001ACHIEVEMENTSGoldberg Segalla Attorneys Recognized in 2014 Pennsylvania Super LawyersMay 23, 2014Goldberg Segalla Attorneys Listed in 2013 Pennsylvania Super LawyersMay 17, 2013Five Goldberg Segalla Attorneys Named in Pennsylvania Super LawyersJune 18, 2012 Michael D. Brophy Selected for Inclusion in Pennsylvania Super Lawyers 2010September 1, 2010NEWSPhiladelphia County Million-Dollar Verdicts - 2010 StatisticsFebruary 19, 2011SUCCESSESReported CasesPhiladelphia and Princeton Offices Combine for an Appellate WinBLOGLife Science MattersProfessional Liability Matters


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BOISE A new law is taking effect July 1 to try and help law enforcement stop thieves in their tracks.
Updates to the 2009 law will target thieves who steal copper wire and construction tools, but law enforcement will need the help of companies that give money for recycled goods.
At Nampa s Pacific Steel and Recycling, Manager Mike Cataldo said companies like his will have to ask patrons for more information.
It s the aluminum, the brass, the copper, the stainless, he said.
The updates require companies that buy certain types of metal from the public to photograph the sellers, their vehicle, their license plate and the material being purchased.
This way we have a good trail for law enforcement, Cataldo said. And if we did do business with them we have a record of that.
Pacific Steel and Recycling is already compliant with the new law, but Cataldo said for some of the other smaller recyclers adding new technology could be difficult.
There are smaller recyclers that may not be able to absorb a cost of an elaborate system like I have, Cataldo said.
The trend to steal copper wire is not a new concept for thieves, and they have been doing it for years and getting away with the crime.
Officials with Idaho Power said the cost to customers from the theft of copper wire ranges in the tens of thousands of dollars every year. Not only is it a felony crime, but also it s not safe. Thieves who target utilities that have copper wire also risk getting electrocuted by the nearby electrical system.
However, with the economy bouncing back and the housing industry once again booming, local law enforcement are also concerned with an increase in construction thefts.
That lull in the housing market, I think has slowed it down a little bit, but knowing that that is coming back up we expect people to try and start attempting the thefts again and so we want to prevent it if we can, said Sergeant Pat Schneider with the Ada County Sheriff s Office.
Schneider asks residents to be on the lookout for strange activity in their neighborhood, especially after hours.
People can get away with things if they have a few extra minutes, said Schneider. Prevention is the cure.
For Cataldo, that is a concern as well because his business depends on it.
If you have a lot of construction going on around town we know, those are our customers, Cataldo said. We get a lot of their business and we don t want to buy anything that is being stolen off of their work sites.
With this new law going into effect on July 1, Cataldo believes that is less likely to happen, but Schneider says residents need to be on the lookout for theft as well.
Anything that we can do to help out law enforcement and do a better job and try to combat theft I am all for it, Schneider said.
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Updated recycling law will target those trying to steal metals
Updated recycling law will target those trying to steal metals
BOISE A new law is taking effect July 1 to try and help law enforcement stop thieves in their tracks.


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Canister Vacuums
Most of us don't enjoy housecleaning chores. In fact most of us dread it. However, vacuum cleaning systems make cleaning easier and faster, thus making the routine grind of cleaning less time consuming. Canister vacuum cleaners are compact and lightweight, so it's easy to tote them up and down the stairs. Storage is easy too, as these canister vacuums can be tucked away into small closets as well. To choose a canister vacuum for your cleaning needs, arrive at a budget, consider the performance of the brand you choose and make a choice between bagged and bagless canister vacuums. We recommend you choose canister vacuums with power selector so you can adapt suction force to the type of floor you clean. Check the weight of the canister vacuum before you choose one, ensure that the power cord is long enough to help you clean large areas and don't forget to consider the filtration system on the canister vacuum you choose. Opt for a HEPA filter if you have allergy sufferers at home.
There are so many varieties of vacuum cleaning systems available in the market today that it can be confusing to choose the best one for your needs and budget. Once you have determined that a canister vacuum cleaner is what you need, GoVacuum can help you narrow your choices further and lead you to the best canister vacuums for your home or office. We provide free shipping on all products and also have a 60-day in-home trial on all of our products. Our aim is to provide you a hassle free online shopping experience for vacuum cleaning systems.
Metro Compact Canister Vacuum w/ Electric Power Nozzle OV-4PNHSF$550.00Portability and industrial power with 4.0 Peak HP and quadruple HEPA filtration system. Tackle tough jobs like a professional with this sleek Retro Stainless Steel/Chrome heavy-duty cleaning system that weighs a surprising 9 pounds. It's light en Learn More
Metro ADM-4PNHSF Canister Vacuum with HEPA Filter$600.00Top-of-the-line total performance cleaning system for the home. 4.0 Peak HP and quadruple HEPA filtration system provide industrial cleaning power reducing cleaning time. The new Metropolitan full-size canister vac offers professional cleaning results w Learn More
Metro 4.0 HP Dual Motor TURBO 2000(r) ADM-4PNH,Vacuum Cleaner$399.00Super powered vac that offers professional cleaning for the home! The Metro® Turbo 2000™ is a sleek, classic, super powered vac that offers professional cleaning for the home. A heavy duty 4.0 Peak HP (12.45 amps) motor combined with efficient Learn More
Royal SR30010 Lexon S10 Canister Vacuum Cleaner$188.83With a barefloor brush and a carpet rug nozzle, the Royal SR30010 provides the ultimate cleaning experience. The Lexon S10 canister vacuum also uses a powerful 10-amp motor to pick up more dirt and dust and keep your home feeling and smelling clean: 360 Swivel. The SR30010 offers a 360 swivel feature that allows you to clean more area without wasting a lot of energy: Full Bag Indicator. The Lexon S10 from Royal features a full bag indicator to tell you when to change the vacuum bag. You won't have to rely on guesswork anymore! Adjustable Suction Control. When cleaning more delicate surfaces, such as drapes or throw rugs, you can adjust the suction dial to prevent sucking unwanted things into the canister vacuum cleaner: On-Board Tools. The Royal SR30010 Lexon S10 canister vacuum comes with a carpet And rug nozzle, a hard floor brush, a upholstery tool, a crevice tool, and a dusting brush for cleaning all types of surfaces. Learn More
Hoover Brushroll Metal End Cap Brushroll Metal End Cap$12.62Works With: Hoover 38-3624-06 Description:Hover Convertible, Deca 80, Upright Vacuum Cleaner Brushroll Metal End Cap (thread guard) With Spring. Fits metal brushrolls where the round rubber belt rides in the center of the brushroll bar. 38-3624-06 Learn More
Hoover UH30010COM Platinum Upright & Compact Canister Vacuums$399.99Hoover UH30010COM Platinum Upright & Compact Canister Vacuums Learn More
Royal Lexon S20 Canister Vacuum Cleaner$599.00Royal Lexon S20 Canister Vacuum Cleaner Learn More
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Author(s): Jacobs, Meg; Novak, William J.; Zelizer, Julian E.
ISBN 10: 0691113777. See all ISBN's
Publisher: Princeton University Press
This is an eTextbook Learn More
In a series of fascinating essays that explore topics in American politics from the nation's founding to the present day , The Democratic Experiment opens up exciting new avenues for historical research while offering bold claims about the tensions that have animated American public life. Revealing the fierce struggles that have taken place over the role of the federal government and the character of representative democracy, the authors trace the contested and dynamic evolution of the national polity.
The contributors, who represent the leading new voices in the revitalized field of American political history, offer original interpretations of the nation's political past by blending methodological insights from the new institutionalism in the social sciences and studies of political culture. They tackle topics as wide-ranging as the role of personal character of political elites in the Early Republic, to the importance of courts in building a modern regulatory state, to the centrality of local political institutions in the late twentieth century. Placing these essays side by side encourages the asking of new questions about the forces that have shaped American politics over time. An unparalleled example of the new political history in action, this book will be vastly influential in the field.
In addition to the editors, the contributors are Brian Balogh, Sven Beckert, Rebecca Edwards, Joanne B. Freeman, Richard R. John, Ira Katznelson, James T. Kloppenberg, Matthew D. Lassiter, Thomas J. Sugrue, Michael Vorenberg, and Michael Willrich.
All ISBN's for this title:
ISBN 10: 0691113777, ISBN 13: 9780691113777, eISBN 10: 1400825822, eISBN 13: 9781400825820
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Author(s): Rodogno, Davide
ISBN 10: 0691166692. See all ISBN's
Publisher: Princeton University Press
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Against Massacre looks at the rise of humanitarian intervention in the nineteenth century, from the fall of Napoleon to the First World War. Examining the concept from a historical perspective, Davide Rodogno explores the understudied cases of European interventions and noninterventions in the Ottoman Empire and brings a new view to this international practice for the contemporary era.
While it is commonly believed that humanitarian interventions are a fairly recent development, Rodogno demonstrates that almost two centuries ago an international community, under the aegis of certain European powers, claimed a moral and political right to intervene in other states' affairs to save strangers from massacre, atrocity, or extermination. On some occasions, these powers acted to protect fellow Christians when allegedly "uncivilized" states, like the Ottoman Empire, violated a "right to life." Exploring the political, legal, and moral status, as well as European perceptions, of the Ottoman Empire, Rodogno investigates the reasons that were put forward to exclude the Ottomans from the so-called Family of Nations. He considers the claims and mixed motives of intervening states for aiding humanity, the relationship between public outcry and state action or inaction, and the bias and selectiveness of governments and campaigners.
An original account of humanitarian interventions some two centuries ago, Against Massacre investigates the varied consequences of European involvement in the Ottoman Empire and the lessons that can be learned for similar actions today.
All ISBN's for this title:
ISBN 10: 0691166692, ISBN 13: 9780691166698, eISBN 10: 1400840015, eISBN 13: 9781400840014
This book may be returned within 15 days of the purchase date, or until you have progressed past the first 1 pages , whichever comes first. Your book is subject to Kno's Terms of Use.
Kno offers a 15-day, no questions asked, money back guarantee for all books you buy or rent through the Kno Bookstore. You are eligible for a full refund so long as you do not exceed the chapter limitation notification that appears in the textbook within a 15-day period.
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On August 13, 2011, the Australian government released a report saying that farmers are damaging one of the nation's greatest assets, the Great Barrier Reef.
The Great Barrier Reef is located off the northeastern coast of Australia and is the largest reef system in the world. It stretches about 2,600 km, composed of more than 2,600 individual reefs and 900 islands, and can even be seen from space. Built on billions upon billions of coral polyps, it supports a wide variety of life.
Although it is generally agreed that climate change is also degrading the reef, the report points to pesticides as a significant factor is undermining reef health. The report found that the operations of up to 12 percent of area farmers used unacceptable practices, especially related to pesticides. There is dispute over whether that percentage has changed since that data was collected, as farmers argue practices have improved. Even so, the findings show how such pollution can adversely affect the natural systems that we, and other life forms, depend upon.
Australia is not the only place where people are concerned about pollution from farming, however. Farmers all over the world rely on toxic chemicals to kill unwanted insects and weeds. These chemicals collect in the local water, and get carried through streams, rivers, and often end up in ocean systems. Polluting water systems is not limited to farming, though. Residents who fertilize and use herbicides, or weed killers, on their lawns also contribute to the toxic runoff, as well as industrial factories, parking lots, and other sources.
This week, you will explore why using pesticides can be a problem. You will also discover what and how other types of pollution harm our environment.
Begin with Ned's story as he learns the hard way about The Proper Handling and Application of Pesticides.
Have your speakers or headphones turned on as you start with the Introduction.
From there you will roll right into the Integrated Pest Management (IPM) segment of the story, where you will learn about the five steps of IPM. At the end of the segment, put each step into the correct order. Check your answers until you get all of them right. Then, continue to the next section about how pesticides affect the environment.
What are the three ways that pesticides can move in the environment? What are the five factors to know about a toxic chemical that will affect how it moves in the environment? How do these influence how and when a person applies the pesticide? What four properties influence its risk of leaching into the environment? How can pesticide use affect the water people and animals drink? Play the Matching game at the end of the segment, and then continue to the Conclusion. Get on the road by dragging onto the truck the things you plan to do as a pesticide applicator.
Pesticides are not the only form of pollution that threatens oceans and other environmental systems. To learn more, visit the National Oceanic and Atmospheric Administration's site about Nonpoint Source Pollution. As you go through this site, draw pictures or take notes about the different aspects and categories of pollution to use later for the newspaper activities.
Begin by reading the introduction that explains what "nonpoint source" means, and then click to watch the video showing urban runoff. Then, read A Brief History of Pollution, explaining how pollution has been around for centuries, but that the different forms of pollution have grown as society has evolved its agriculture, industry, business, and social norms. Some laws have curbed pollution output and risks to the environment. However, many threats still exist.
Dive into the categories of pollution by learning about the difference between Point Source pollution and Nonpoint Source pollution. In what ways do you think laws and regulation are different between the two types? Which one is likely easier to control and why? How can pollution affect local economies?
Next, discover how Urban and Suburban Areas contribute to nonpoint source pollution, as well as Agricultural Operations. What are the similarities and differences between these two types of areas? In what ways do you think people living there help reduce this type of pollution?
Where people live and grow food are not the only culprits of nonpoint source pollution, however. There are Atmospheric Inputs, such as from a variety of industries and air travel, that causes acid rain, as well as from Forestry and Mining Operations and Marinas and Boating Activities.
Now, move on to the types of pollution, which includes Nutrients, Suspended Sediments, and Pesticides and Toxic Chemicals. Bacteria, Viruses and Trash also contribute to pollution and can harm the environment. Using your drawings or notes, compare and contrast these different types of pollution by writing one or more paragraphs.
Continue your exploration by finding out about how Research, Monitoring and Assessment efforts help scientists and resource managers keep a watch on conditions and predict risks. Also, learn about ways of Controlling Nonpoint Source Pollution — list them with their description in your own words or through illustrations. Lastly, discover What You Can Do to help prevent nonpoint source pollution. What actions listed here have you, your household, friends, neighbors or other people in the community taken that you know about?
Browse through issues of the e-edition to find up to five articles that mention a different activity that may contribute to nonpoint source pollution in your area. Using a letter-sized or larger sheet of paper, create an information poster about the pollution source. Describe what the source is, what category and type of pollutant it is, and in what specific ways it could harm the environment, including where the toxins would end up if they flowed through the water system. Also, what preventative steps could be taken to help minimize dispersal into the environment? As desired, use a combination of writing and illustrations to feature each source. Share your featured sources with classmates.


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You said, "I remember how we felt, sitting by the water
And every time I look at you, it's like the first time
I fell in love with a careless man's careful daughter
She is the best thing that's ever been mine."
from Taylor Swift – Mine Lyrics on Genius
He remembers everything she states in the song, although she is preparing for a broken heart. He surprises her
To help improve the quality of the lyrics, visit Taylor Swift – Mine Lyrics and leave a suggestion at the bottom of the page


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Raonic Battles Past Sock In Toronto
Toronto, Canada
by ATP Staff|
Top Canadian and returning finalist Milos Raonic survived a scare on Wednesday night at the Rogers Cup, prevailing against fast-rising American Jack Sock 4-6, 7-6(2), 7-6(4) after two hours and 24 minutes.
The 60th-ranked Sock earned the lone break of the match to go up 3-2 in the opening set. He had his chances to silence the Toronto fans, but was unable to convert his five ensuing break points over the next two sets.
Read: Djokovic Overcomes Monfils
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Raonic, who edged Sock in two tie-breaks last week in Washington, once again came up big in the crucial moments. He improved to a 21-8 mark in tie-breaks this season, winning his eighth straight to claim victory. It was the fourth match Wednesday decided in a third-set tie-break.
"I feel good in those [tie-break] situations, especially if things are not going throughout the set the way I would have liked," said Raonic. "I'm not converting opportunities or giving away too many opportunities. I know that if I can get it to a tie-break, I can sort of tip things in my favour."
The 23 year old had won the Citi Open title on Sunday, defeating Vasek Pospisil in the first all-Canadian final on the ATP World Tour. The 21-year-old Sock, who won the Wimbledon doubles title with Pospisil last month, had reached back-to-back semi-finals in Newport and Atlanta before falling to Raonic in the Washington second round.
"I have a fairly decent amount of confidence right now in general just from the summer," said Sock. "[It] feels like everything is falling in place for me right now. I'm really looking forward to the rest of the year and the rest of the summer. Hopefully I can just keep going."
Raonic, the World No. 6, will next face Julien Benneteau, who upset 11th seed Ernests Gulbis 7-6(4), 6-3 earlier Wednesday. Raonic leads the Frenchman 2-1 in their FedEx ATP Head2Head Series.
Spaniard Feliciano Lopez defeated another American, Tim Smyczek, 7-5, 6-4, to set up a third-round meeting with fourth seed Tomas Berdych, winner over Yen-Hsun Lu 6-7(4), 6-4, 6-4 in the final match on Wednesday evening.
Berdych bounced back after losing the first-set tie-break to secure victory in two hours and 18 minutes. The 28 year old, who claimed his ninth ATP World Tour title on the indoor hard courts of Rotterdam in February, improved to 3-0 against his opponent from Chinese Taipei. The World No. 5 was coming off a third-round exit (l. to Pospisil) at last week's Citi Open in Washington D.C., where he was the top seed.
Meanwhile, South African Kevin Anderson will face third seed Stan Wawrinka after ousting No. 16 seed Fabio Fognini 7-5, 6-2.
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January 27, 2011
Richard Smith has had a song in his heart through much of his life. Now he'll have a chance to "Sing for Life."
Smith, 78, will be among the local residents competing in the "Sing for Life" karaoke competition at 6:30 tonight at Rest Haven Convalescent and Retirement Home, 1500 S. Ingram Ave. All proceeds from the event, which will feature children and adults competing for trophies by singing their favorite songs, will go to the American Cancer Society's Relay for Life.
While Rest Haven residents typically just come out to watch the performances, Smith, who lives at the home, has decided he wants to be on stage.
"Well, it's something I love to do," he said. "If you love to do it, then you'll try to do it."
Smith is not sure what he will be singing, since he hasn't seen the song list. The last time he sang karaoke, he found only one song on the list that was his style: "Almost Like Being in Love" from the musical "Brigadoon." He said if he couldn't find any songs from musicals on the list, he'd really like to sing the cowboy classic "Ghost Riders in the Sky."
Smith had always enjoyed singing in the car to his wife, to whom he was married for more than 40 years before she died soon after being diagnosed with cancer.
Stephanie Louiselle, minimum data set coordinator at Rest Haven, encourages the public to participate. The cost is $3 for adults and $2 for children ages 7 to 15. Children age 6 and younger will be admitted free. The contest includes three different age categories for children and an adult division. Last year, 22 people competed.
All singers will receive a number when they sign up and refreshments will be served. Louiselle said the residents enjoy not only watching the children sing, but seeing their reactions when they win.
Rest Haven tries to host a variety of fundraisers to benefit Relay for Life between September and April, ranging from silent auctions to haunted courtyards, winter festivals and spring barbecues.


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Shaun Donovan, Housing and Urban Development secretary for President Barack Obama, has become the first sitting Cabinet official to declare support for marriage rights for same-sex couples. Speaking at an event benefiting the National Center for Transgender Equality, Donovan told Metro Weekly he "absolutely" supports the right of gays and lesbians to marry.
View Full Article in:Metro Weekly (Washington, D.C.)
Published in Brief:


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chemokine (C-C motif) receptor 5 (gene/pseudogene)
PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB annotates drug labels containing pharmacogenetic information approved by the US Food and Drug Administration (FDA), European Medicines Agency (EMA) and the Pharmaceuticals and Medical Devices Agency, Japan (PMDA). PharmGKB annotations provide a brief summary of the PGx in the label, an excerpt from the label and a downloadable highlighted label PDF file. A list of genes and phenotypes found within the label is mapped to label section headers and listed at the end of each annotation. PharmGKB also attempts to interpret the level of action implied in each label with the "PGx Level" tag.
- FDA Information is gathered from the FDA's "Table of Pharmacogenomic Biomarkers in Drug Labels" and from FDA-approved labels brought to our attention. Please note that drugs may be removed from or added to the FDA's Table without our knowledge. We periodically check the Table for changes and update PharmGKB accordingly. Drugs listed on the Table to our knowledge are tagged with the Biomarker icon. A drug label that has been removed from the Table will not have the Biomarker icon but will continue to have an annotation on PharmGKB stating the label has been removed from the FDA's Table. We acquire label PDF files from DailyMed.
- EMA European Public Assessment Reports (EPARs) that contain PGx information were identified from [Article:24433361] and also by searching for drugs for which we have PGx-containing FDA drug labels.
- PMDA Japanese drug label annotation information is sourced from Shimazawa and Ikeda (2013), whose paper provided translations of the pharmacogenetic information contained in PMDA package inserts. The authors selected which PMDA package inserts to examine for PGx information based the FDA's "Table of Pharmacogenomic Biomarkers in Drug Labels".
We welcome any information regarding drug labels containing PGx information approved by the FDA, EMA, PMDA or other Medicine Agencies around the world - please contact feedback.
Annotated Labels
FDA Label for maraviroc and CCR5
The drug labeling for maraviroc is not related to genetic testing of the patient, rather testing of the HIV-1 strain that has infected the patient. The FDA-approved label states that HIV tropism testing be carried out before treatment with Maraviroc. This drug is indicated only for CCR5-tropic HIV-1 infection, and due to its mechanism of action, is not effective against CXCR4-tropic and dual-tropic HIV-1.
Maraviroc (Selzentry) is a CCR5 antagonist, and works by preventing HIV-1 from entering cells via the CCR5 cell surface receptor. The drug labeling information demonstrates why a sensitive HIV tropism assay should be used to diagnose CCR5-tropic HIV-1, in order to avoid treating individuals with CXCR4- or Dual/ Mixed- tropic virus (discussed in section 14.3).
Maraviroc is principally metabolized by CYP3A enzymes. Drug labeling information also includes Maraviroc dosage recommendations if CYP3A inhibitors or CYP3A inducers are taken concomitantly.
Excerpt from the maraviroc drug label:
SELZENTRY, in combination with other antiretroviral agents, is indicated for adult
patients infected with only CCR5-tropic HIV-1.
The following points should be considered when initiating therapy with SELZENTRY:
- Adult patients infected with only CCR5-tropic HIV-1 should use SELZENTRY.
- Tropism testing must be conducted with a highly sensitive tropism assay that has demonstrated the ability to identify patients appropriate for use of SELZENTRY. Outgrowth of pre-existing low-level CXCR4-or dual/mixed-tropic HIV-1 not detected by tropism testing at screening has been associated with virologic failure on SELZENTRY
For the complete drug label text with sections containing pharmacogenetic information highlighted, see the Maraviroc drug label.
*Disclaimer: The contents of this page have not been endorsed by the FDA and are the sole responsibility of PharmGKB.
Genes and/or phenotypes found in this label
- Indications & usage section, Information for patients section, Description section, Clinical studies section, Mechanism of action section, Pharmacokinetics section, Warnings and precautions section, Microbiology section, efficacy
- source: FDA Label
- Dosage & administration section, Contraindications section, Drug interactions section, Overdosage section, Pharmacokinetics section, Use in specific populations section, Warnings and precautions section, dosage
- source: FDA Label
- Dosage & administration section, Contraindications section, Drug interactions section, Overdosage section, Pharmacokinetics section, Use in specific populations section, Warnings and precautions section, dosage
- source: FDA Label
European Medicines Agency (EMA) Label for maraviroc and CCR5
The drug labeling for maraviroc is not related to genetic testing of the patient, rather testing of the HIV-1 strain that has infected the patient. The EMA European Public Assessment Report (EPAR) for Maraviroc (CELSENTRI) contains information regarding its indication only in patients with CCR5-tropic HIV-1 and not CXCR4- or dual/mixed tropic virus, due to its mechanism of action as a CCR5 antagonist.
The EPAR details that a test on newly drawn blood should be carried out prior to treatment to confirm only CCR5-tropic HIV-1 virus is detectable and treatment should be started soon after the test. Under safety data, the EPAR states that no significant adverse consequences in humans that lack CCR5 expression due to genetic deletion have been reported.
Excerpts from the Maraviroc (CELSENTRI) EPAR:
Maraviroc selectively binds to the human chemokine receptor CCR5, preventing CCR5-tropic HIV-1 from entering cells.
Maraviroc has no antiviral activity in vitro against viruses which can use CXCR4 as their entry co-receptor (dual-tropic or CXCR4-tropic viruses).
Before taking CELSENTRI it has to be confirmed that only CCR5-tropic HIV-1 is detectable (i.e. CXCR4 or dual/mixed tropic virus not detected) using an adequately validated and sensitive detection method on a newly drawn blood sample. The Monogram Trofile assay was used in the clinical studies of CELSENTRI (see sections 4.4 and 5.1). Other phenotypic and genotypic assays are currently being evaluated. The viral tropism cannot be safely predicted by treatment history and assessment of stored samples.
This information is highlighted in the following sections:
Therapeutic indications, posology and method of administration, tropism, pharmacodynamic properties, preclinical safety data, package leaflet - information for the user.
For the complete drug label text with sections containing pharmacogenetic information highlighted, see the Maraviroc (CELSENTRI) EMA drug label.
*Disclaimer: The contents of this page have not been endorsed by the EMA and are the sole responsibility of PharmGKB.
Genes and/or phenotypes found in this label
- Dosage & administration section, Drug interactions section, Pharmacokinetics section, Warnings and precautions section, metabolism/PK
- source: European Medicines Agency (EMA) Label
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
List of all variant annotations for CCR5
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
[ close ]
|Alternate Names ?
|Drugs ?
(+ chr strand)
|Function ?
Amino Acid?
|46354947_46354978del32, 46414947_46414978del32, 554_585del32, 8315_8346del32, CCR5: 554_585del32, Ser185_Thr195delinsIlefs, delta32, ¿32
|Alternate Names:
|Alternate Symbols:
|PharmGKB Accession Id:
|Cytogenetic Location:
|chr3 : p21.31 - p21.31
|GP mRNA Boundary†:
|chr3 : 46411633 - 46417697
|GP Gene Boundary†:
|chr3 : 46401633 - 46420697
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.View on UCSC Browser
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.
External Pathways
Links to non-PharmGKB pathways.
Publications related to CCR5: 10
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
[ close ]
- UniProtKB:
- Ensembl:
- GenAtlas:
- GeneCard:
- MutDB:


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BC Emergency Health Services
BC Emergency Health Services (BCEHS), formerly the Emergency and Health Services Commission (EHSC), will continue with a mandate of providing provincial ambulance and emergency health services under the Emergency and Health Services Amendment Act, 2013.
BCEHS is currently responsible for three operating entities. BC Ambulance Service provides emergency health services and ambulance services throughout the province of British Columbia. The BC Patient Transfer Network is responsible for planning and coordination of all inter-facility patient transfers.
For more information about the operating entities of BCEHS, please see the links to the right.
BCEHS offers a wide range of exciting and challenging career opportunities for people who are passionate about making a difference. For more information on careers with BCEHS and to view the opportunities open to the general public at this time please click here.


text:
Category 45 - Best Contemporary Jazz Album
(For albums containing 51% or more playing time of INSTRUMENTAL tracks.)
Dave Douglas
[Greenleaf Music]
Bill Evans
[BHM Productions]
The Way Up
Pat Metheny Group
The Spirit Music Jamia: Dance Of The Infidel
Meshell Ndegeocello
[Shanachie Entertainment Corp.]
Joshua Redman Elastic Band
Category 46 - Best Jazz Vocal Album
(For albums containing 51% or more playing time of VOCAL tracks.)
J'ai Deux Amours
Dee Dee Bridgewater
[Sovereign Artists]
Blueprint Of A Lady - Sketches Of Billie Holiday
Nnenna Freelon
[Concord Jazz]
Good Night, And Good Luck
Dianne Reeves
[Concord Jazz]
Duos II
Luciana Souza
I'm With The Band Tierney Sutton [Telarc Jazz]
Category 47 - Best Jazz Instrumental Solo
(For an instrumental jazz solo performance. Two equal performers on one recording may be eligible as one entry. If the soloist listed appears on a recording billed to another artist, the latter's name is in parenthesis for identification. Singles or Tracks only.)
'Round Midnight
Alan Broadbent, soloist
Track from: 'Round Midnight
[Artistry Music]
Ravi Coltrane, soloist
Track from: In Flux
[Savoy Jazz]
The Source
Herbie Hancock, soloist
Track from: Flow (Terence Blanchard)
[Blue Note Records]
A Love Supreme - Acknowledgement
Branford Marsalis, soloist
Track from: Coltrane's A Love Supreme Live In Amsterdam
[Marsalis Music]
Why Was I Born?
Sonny Rollins, soloist
Track from: Without A Song - The 9/11 Concert
Category 48 - Best Jazz Instrumental Album, Individual or Group
(For albums containing 51% or more playing time of INSTRUMENTAL tracks.)
Terence Blanchard
[Blue Note Records]
Billy Childs Ensemble
[Lunacy Music/Artistshare]
Live At The House Of Tribes
Wynton Marsalis
[Blue Note Records]
Beyond The Sound Barrier
Wayne Shorter Quartet
What Now?
Kenny Wheeler With Dave Holland, Chris Potter & John Taylor
[CAM Jazz]
Category 49 - Best Large Jazz Ensemble Album
(For large jazz ensembles, including big band sounds. Albums must contain 51% or more INSTRUMENTAL tracks.)
Dave Holland Big Band
A Blessing
John Hollenbeck Large Ensemble
The Bill Holman Band
[Jazzed Media]
I Am Three
Mingus Big Band, Orchestra & Dynasty
[Sunnyside/Sue Mingus Music]
Home Of My Heart
The Chris Walden Big Band
Category 50 - Best Latin Jazz Album
(Vocal or Instrumental.)
Time Was - Time Is
Ray Barretto
[O Plus Music]
Here And Now - Live In Concert
Caribbean Jazz Project Featuring Dave Samuels
[Concord Picante]
...And Sammy Walked In
Sammy Figueroa And His Latin Jazz Explosion
[Savant Records]
Listen Here!
Eddie Palmieri
[Concord Picante]
Omar Sosa
[Ot Records]
Category 61 - Best Traditional Tropical Latin Album
(Vocal or Instrumental.)
Una Noche Inolvidable
Afro-latin Jazz Orchestra With Arturo O'Farrill
[Palmetto Records Inc]
Masters Of Cuban Son
Conjunto Progreso
[Pimienta Records Corp.]
Buena Vista Social Club Presents
Manuel Guajiro" Mirabal
Tropicana All Stars With Israel Kantor
[Regu Records Corp.]
Bebo De Cuba
Bebo Valds
[Calle 54 Records]
Category 84 - Best Instrumental Arrangement
(An Arranger's Award. (Artist names appear in parenthesis.) Singles or Tracks only.)
Chris Walden, arranger (The Chris Walden Big Band)
Track from: Home Of My Heart
Do It Again
Bill Cunliffe, arranger (Bill Cunliffe)
Track from: Imaginacin
The Incredits
Gordon Goodwin, arranger (Various Artists)
Track from: The Incredibles - Soundtrack
[Walt Disney Records]
Lullaby Of The Leaves
John Clayton, arranger (The Clayton-Hamilton Jazz Orchestra)
Track from: The Clayton-Hamilton Jazz Orchestra, Live At MCG
[MCG Jazz]
Scarborough Faire
Billy Childs, arranger (Billy Childs Ensemble)
Track from: Lyric [Lunacy Music/Artistshare]
View All About Jazz's 2005 Contributor Picks.


text:
- Price: $155.00
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Electronics Store CRE Loaded Template 13668
CRE Loaded Template that was composed by our webmaster artist Glenn.
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Description, Sources, Software & Requirements
Online shop template with a black, blue, and white color scheme and a rocking theme. There is a girl rocking away to her favorite tunes in the header beside a simple customizable blue and black logo. There are three columns of black and blue text over white backgrounds. On display are various electronics such as monitors and laptops along with cameras. Electronics Store CRE Loaded Template 13668 is available in the following sources: .PSD, and .PHP. Software required includes Winzip 9+ (Windows) or Stuffit Expander 10+ (Mac) for uncompressing .zip files, Adobe Photoshop CS+, Hosting with PHP4x and MySQL4x, Adobe Dreamweaver 8+ (or any php-editor), Apache Only (on Unix/Freebsd/Linux/Windows), and CRE Loaded 6.2[10+] Standard and. It has had a total of total of 4 downloads since it first appeared.


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Elements MassageChester
The Streets of Chester
170 Route 206 South
Chester, NJ 07930
p. (908) 888-2071
Hours of Operation
Monday - Saturday
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We accept SpaFinder.com
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The Elements Way.™ Therapeutic, handcrafted, and personalized massage. Learn More.
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Prenatal massage can help relax body and mind, both for you and your child. Learn more about the benefits of prenatal massage. Read More >
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Mother's Day is just around the corner and it is the perfect opportunity for moms to take advantage of a therapeutic massage. Learn more with Wellness News. Read More >
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Massage now can help prepare you mind and body for the summer heat and fun ahead. Read more from Wellness News. Read More >
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The Securities and Exchange Commission today unanimously proposed two alternative requirements for money market funds. First, the SEC would require institutional prime money market funds to operate with a floating net asset value (NAV). Separately, the SEC would require non-government money market funds to adopt "fees and gates" to stem redemptions in times of stress.
In her remarks at the open meeting, Chairman Mary Jo White said that it has been "a journey to get to this point." She said that the proposals are important "because they advance the public debate that will shape the final rules to address one of the most prominent events arising from the financial crisis."
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Drug maker Cipla on Wednesday said it will focus on strengthening front-end presence in its key markets, and is looking at hiring more senior-level talent.
"We have decided that we must do front-ending in priority areas in the US, Europe and Africa. We will look at more markets. Our sales outside India at present are around 55%, which may go up to 65% over the next few years. So we will look outside India both in terms of sales and new geographies," Y K Hamied, chairman, Cipla, said at the company's 78th annual general meeting on Wednesday.
He said the company will hire senior-level talent and senior professionals to set up front-end activity in both the US and Europe.
Also, the company sees 15% growth in revenues this fiscal.
"We expect mid-teens topline growth, which is around 15% for the current financial year. We also expect to maintain margins similar to last year. Our focus would be on two key areas, that is to drive future growth through our product pipeline and hiring the right talent."
Shubhanu Saxena, managing director and global CEO, Cipla, said the company is looking at geographically balanced portfolio.
"Strategy outside India is to enter more market and not through intermediaries. We will be selective as where we think opportunities are right. We are looking at selectively building front-end presence in markets such as North America through our pipeline and other markets in Asia, Middle East, Central Europe and Latin America."
The focus will be on priority markets where the company has strong relationship with its partners, like in Sri Lanka and Yemen, he said.
"We will combine the local strength of our partners along with Cipla's pipeline through joint ventures. There will be continued front-ending every year whenever we are ready and the timing is right." Saxena said.
The company has presented a three-year road before the board of directors and plans course-correct every six-nine months.
On hiring senior talent, Saxena said, "Initial hiring to build capability has already been done. We are also promoting talents from within. Our focus for the next two years is to create a strong bench within the company. We have moved talents from India to South Africa and we are also moving some of our top talents to other markets."
The company recently launched an anti-asthma inhaler in Germany and Sweden which is a generic version of GlaxoSmithKline Plc's Advair. Hamied said the market size for inhalers in Europe is 2.5 billion euros with around 30 million patients under the age of 45 years suffering from asthma.
The company is planning a series of launches in Europe over the next 12-18 months.
Cipla would also spend around Rs 600 crore on research & development during this year to implement research oriented projects. "This year we will spend around Rs 600 crore in R&D and efforts are directed towards accountable and implementable research-oriented projects," Hamied said in his AGM speech.


text:
Results 1 to 4 of 4
October 15th, 2008 #1Registered User
- Join Date
- Mar 2008
- Posts
- 57
- Thanks
- 4
- Thanked 10 Times in 10 Posts
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Recommend a fundementals course...
Howdy All,
I have some drawing and painting skills but I'm far from a well versed artist. Lately I've come to believe that I may have "missed a step" in my hodge podge self-training and that its holding me back. I want to rectify that.
Therefore, I am going to go through a fundamentals curriculum. In order to find the right one (or several) I'm reading, skimming and scanning my way through everything I can get my hands on.
Please recommend (link when possible) your favorite books and tutorials which assume that one is starting from ZERO. To say it another way, I'm looking for pre-figure fundamentals. Seeing, measuring, modeling, etc.
Ianianstrandberg.com (blogfolio)
CA.ORG Sketchbook
CRITIQUE REQUEST: Zombie Cheesecake
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Hide this ad by registering as a memberOctober 15th, 2008 #2
Dividing 2D space, dark and light pattern(value), color: http://www.archive.org/details/compo...erie00dowauoft
Also found Heinrich Wolflinn's "Principle's of Art History" helpful in learning about the difference between pieces of art that stress a plane, or depth, whether it's sculpture, architecture, or painting.
Nathan Hale's "Abstraction in Art and Nature". Has useful patterns and things to look for when drawing from life.
"Beliefs are rules for action"
"Knowledge is proven in action."
"It's use is it's meaning."
October 15th, 2008 #3
There's a wonderful book called Drawing on the Right Side of the Brain that may just do the trick. Check that out, man.
Only the heart intrinsically noble can succeed...
Check out My Sketchbook: Leave critiques, encouragement, and good jokes within.
October 15th, 2008 #4Registered User
- Join Date
- Mar 2008
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- 57
- Thanks
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- Thanked 10 Times in 10 Posts
- Follows
- 0
- Following
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Thanks very much! I started reading Dowauft's Composition and I feel it is most promising. I'm working on getting my mits on the others mentioned.
I currently have (among other things) a copy of "A Guide to Drawing" by Medelowitz, Wakeham and Faber. It's a textbook and it *seems* to be pretty good. Any experience with this title?
ianstrandberg.com (blogfolio)
CA.ORG Sketchbook
CRITIQUE REQUEST: Zombie Cheesecake
Friend me on: