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Apps Posts - Page 14
Google updates MyGlass app to version 3.0, sports new interface
Google Glass users, get to your smartphones and update your MyGlass app, as it has just hit version 3.0. The latest MyGlass app has a great new interface in the form of a new slide-in bar that comes in from the left, providing quick access to settings, contacts, active Glassware and new Glassware to install.
The interface for adding and managing your Glassware has been improved, with the app overall being much more stable and improved. You can also now share maps directly from your phone to Glass, something that is going to make things much easier than trying to speak into Glass and it not understand which address you're trying to say - something that happened to me just a couple of hours ago.
iOS devs gain the ability to offer promo codes for in-app purchases
Apple has made an interesting change to the App Store and how developers can gift things to players of their games. Developers can now offer gamers promo codes for free in-app purchases. Promo codes have been accepted for game purchases for a while, but allowing them for in-app purchases is a new feature.
One of the first mobile game developers to take advantage of in-app promo codes was EA. It offered a promo code to players of Real Racing 3 if they visited the EA website. The code gave the players some free gold.
Continue reading 'iOS devs gain the ability to offer promo codes for in-app purchases' (full post)
Mobli updates smartphone app to support live video streaming
Mobli is a company from Israel that makes an app for smartphone users that allows them to take and share video and photos. The company has announced that it has updated that app to allow users to do something interesting, live broadcast video. Users of the smartphone application can watch that video in real-time.
The apps are available for iOS and Android users right now. The app only just gained the ability to live broadcast video with an update that went live this week. To be able to watch the live broadcasts, users do need to have the app installed on their devices.
Continue reading 'Mobli updates smartphone app to support live video streaming' (full post)
Flappy Bird is making a comeback, with "less addictive" gameplay
Flappy Bird is coming back, with developer Dong Nguyen revealing the news to CNBC during an interview. When the game makes its comeback, it will be include new features, multiplayer support and "less addictive" gameplay.
During his interview with CNBC, Nguyen said that Flappy Bird had been downloaded over 50 million times before he took the game down. Flappy Bird was generating $50,000 per day in ads alone when it was at its peak. Once Flappy Bird was taken down, clones began to surface, as well as people trying to capitlize on its success by selling devices with Flappy Bird installed for thousands on eBay.
Yahoo acquires Blink, SnapChat's biggest rival, plans to shut it down
A growing trend in the tech world seems to be building a product designed to get you noticed by the big tech companies in hopes that they will acquire you for your talent and IP, and that seems to be exactly what has just happened to SnapChat rival Blink. Blink is an app that allows users to send self destructing instant messages, and functions similarly to how SnapChat works, and today the company announced that Yahoo has swooped in and picked it up.
"I can confirm that the entire team behind Blink will be joining our mobile team in Sunnyvale where they will focus on smart communication products," a Yahoo rep confirmed in a statement. Unfortunately, Yahoo plans to shut Blink down and will use the development team and founders to work on other Yahoo products. Details of the acquisition were not very clear, and at the moment, no word on how much the deal was worth has been released.
Watch out Whatsapp, WeChat has almost 400 million monthly active users
Facebook's Whatsapp may have some contending to do in the coming months for its top spot in the world of mobile instant messaging. Today Whatsapp rival, WeChat, announced its earnings report for the first quarter of its fiscal 2014 year. While this would not usually be major news, the fact that WeChat grew by almost 50 million active monthly users caught our eye.
At the end of 2013, WeChat had about 355 million active monthly users, and now the company is reporting that during the first quarter of 2014, it managed to grow its user base to 396 million active monthly users. This number covers both WeChat and Weixin, the Chinese version of the app. With user numbers rising this fast, we could see WeChat top 500 million by the end of the year.
Google Maps update adds public transportation details in Great Britain
Google Maps has issued an update for the app that adds in public transportation details for people traveling in Great Britain. The update adds in train and bus details across England, Scotland, and Wales. Users can now access public transportation info for London and the South East using the iOS and Android apps.
Desktop users of Google Maps will also be able to search National Express and Traveline data along with data on other local and national operators. Those operators include Centro and Merseyside. Data in the updated apps include info on almost 17,000 routes and 34,000 stopping points, ferry points, and stations.
Continue reading 'Google Maps update adds public transportation details in Great Britain' (full post)
Yahoo gobbles up mobile messaging app startup Blink, shuts it down
Yahoo has announced that it has purchased a Snapchat-like mobile messaging app called Blink. Blink allowed people to send messages that would self-destruct and allowed them to control who sees their messages and how long those people could see them. Fans of Blink won't be thrilled to hear that Yahoo plans to shut the company down.
Blink apps on the iOS and Android platforms will be shutting down in the coming weeks. What Yahoo will do with the tech and talent that it acquired with the purchase is unknown. Presumably, Yahoo will rebrand the tech as its own and re-launch it at some point in the future.
Continue reading 'Yahoo gobbles up mobile messaging app startup Blink, shuts it down' (full post)
Gmail for Android has been downloaded over 1 billion times
Gmail has been the most widely used e-mail service in the world for close to two years, but Google has just reached another important milestone: Gmail for Android has become the first app in the Google Play Store to reach 1 billion downloads.
The 1 billion number might not represent 1 billion active Gmail users, but the Mountain View-based search giant did report that it had over 425 million active monthly users back in 2012. This is a number that is sure to have exponentially grown, along with its mobile OS, Android.
Square unveils new Feedback service, lets customers talk to retailers
I am one of those people who give feedback to many of the restaurants, retailers, and places I do business in, and today, Square made giving that feedback much easier for those merchants who utilize square. The new Feedback feature unveiled by Square is a $10 per month service that lets consumers rate and comment on how their experience went with a square merchant.
Additionally, the Feedback service lets those merchants reply to customer comments, and could be an excellent way to let a business owner know about bad or good service their staff may be providing. Square is offering the new Feedback service as a 30-Day free trial and then charging a per month fee per square account after that trial is up. Square Feedback is free for consumers.


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La Salle, FEU triumph in UAAP men's volleyball
More News from Celest R. Flores
More News from INQUIRER.net
MANILA, Philippines—La Salle got a boost to the top four with a 25-19, 25-22, 25-20 over Ateneo on Thursday in the UAAP season 75 men's volleyball at the Arena in San Juan.
Christopher Antonio scored on game-best 14 hits as the Archers capitalized on the Blue Eagles' error-prone game for 23 points.
La Salle tied with Adamson at third place with an 8-5 record, while University of Santo Tomas lurks behind at fifth with a 7-6 card.
Meanwhile, Far Eastern University survived past also-ran University of the Philippines, 25-22, 25-27, 25-19, 23-25, 15-9.
Each one from the Tamaraws' side, who remained in second place with an 11-2 card, chipped in at least two points with Ranie Yumang dropping a team-high 17 points.
Get Inquirer updates while on the go, add us on these apps:
Disclaimer: The comments uploaded on this site do not necessarily represent or reflect the views of management and owner of INQUIRER.net. We reserve the right to exclude comments that we deem to be inconsistent with our editorial standards.
To subscribe to the Philippine Daily Inquirer newspaper in the Philippines, call +63 2 896-6000 for Metro Manila and Metro Cebu or email your subscription request here.
Factual errors? Contact the Philippine Daily Inquirer's day desk. Believe this article violates journalistic ethics? Contact the Inquirer's Reader's Advocate. Or write The Readers' Advocate:
c/o Philippine Daily Inquirer Chino Roces Avenue corner Yague and Mascardo Streets, Makati City,Metro Manila, Philippines Or fax nos. +63 2 8974793 to 94

subset: commoncrawl


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Opening Times
Keep up to date with special offers, news and information.
Your booking is safe with Virgin Holidays
Fitness Centre
Internet Access
Swimming Pool
Beach Holiday
Half Board
I would like to see late deals for stays of:
Prices shown are per person, based on [PartySize] sharing.
A new resort, the Poste Lafayette Resort & Spa offers accommodation in a beautiful location, overlooking a gorgeous stretch of sandy beach. Ideal for couples, families are well catered for too with guest rooms, shallow waters to splash about in and a kids club, Jules Verne, packed to the hilt with fun activities. Teens aren't left out either; they can head to E-Zone, a special chilling place exclusively for them! With kids and teens taken care of, parents can enjoy a spot of well-earned time out, lazing by the lovely free-form swimming pool perhaps or indulging in a rejuvenating treatment or two at Spa Cenvaree, a haven of peace and tranquility. Dining-wise, you've three restaurants to choose from, Cafe Nautilus, serving sumptuous buffet delights, Phi, boasting a more intimate atmosphere and speciality dishes and Aqua 180, a beachside restaurant combining tasty comfort food, burgers and freshly baked pizzas, with the convenience of being steps away from the crystal clear waters.
In Poste Lafayette, on the north-eastern coast of Mauritius, approximately 15km from Central Flaq and 25km from Grand Baie. Transfer time from the airport: 1 hour.Larger Map
All with air-conditioning, some with juliet balcony or terrace, satellite TV, telephone, free WiFi, mini bar*, tea/coffee maker, safe and hairdryer. Superior Mountain View Rooms with juliet balcony, 1 king-size bed and sofa bed or twin on request sleeping max 2 adults and 2 children. Please note the Superior Mountain View Rooms are located adjacent to the hotel, separated by a coastal road.
Deluxe Ocean Facing Rooms with juliet balcony, 1 king-size bed and sofa bed or twin on request sleeping max 2 adults and 1 child.
Deluxe Garden Terrace Rooms with 1 king-size bed sleeping max 2 adults.
Deluxe Ocean Front Terrace Rooms with 1 king-size bed sleeping max 2 adults.
Deluxe Ocean Front Rooms with juliet balcony, 1 king-size bed and sofa bed on request sleeping max 2 adults and 2 children.
Café Nautilus (buffet), Phi (Italian cuisine; dinner), Aqua 180 (beachside restaurant and bar). Swimming pool. Fitness centre. Snorkelling. Spa Cenvaree*. Kids club (3-11 years). Daily activities programme. E Zone for teens. Kayaking, use of pedal boats, glass bottom boat trips and bicycle tours*. PADI Dive* is available nearby and be arranged by the hotel. Laundry/dry cleaning service*. Room service* (7.00am-10.00pm). Free WiFi.
Half board plus includes: Buffet Breakfast, set lunch menu or buffet lunch and themed buffet at Cafe Nautilus. A La Carte for lunch and dinner also available at Aqua 180. A choice of lunch or dinner accompanied by a maximum 3 hour open bar with the meal from the time you arrive. The open bar includes standard drinks such as non alcoholic beverages, beer and local spirits only.
*Denotes local charge.
Buffet breakfast, set lunch menu and themed buffet dinner at Café Nautilus. Set menu for lunch and dinner also available at Aqua 180. Daily credit of £20 for a la carte dining at Phi speciality restaurant. Afternoon tea served at Aqua 180 from 3.30pm – 5.00pm. Mini-bar replenished daily with house brand beers, soft drinks, juices and mineral water. Selected domestic drinks: house wines, beers, spirits, cocktails, soft drinks, juices, mineral water, and tea and coffee. Water sports with snorkeling, pedal boats and kayaking. Beach volleyball, beach badminton, bocce balls, and unlimited access to fitness centre.
Upgrade to Gold All Inclusive and receive:
- Complimentary replenished mini-bar with beverage, soft drinks and snacks
- One Category room upgrade guaranteed
- USD 100 allowance per day for Spa Cenvaree ( Non Accumilative )


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Patient Portal
Pediatrics of Southwest Houston started using an electronic medical record in July 2014. Thank you for your patience with us during this time of transition; it has been a challenge but we are excited about the opportunities we have now to offer our patients new services. We are launching our patient portal in February 2015. Once you sign up for an account you will be able to view and print your child's immunization record, growth chart, and lab results. You will also be able to request a non-urgent appointment online, update contact information, and make payments. Coming soon will be the ability to request medication refills and view patient summary notes. Click on Learn More to register for the portal.


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Under Armour Men's Alter Ego Compression T-Shirt
$44.99 $60.00*
Save $15.01 (25%)
Product Information:
Channel your inner superhero when you work out in the Under Armour® Men's Alter Ego T-Shirt. Available in styles that mimic comic book characters, this fitted top keeps your muscles engaged and decreases your recovery time so you can bulk up like your idols. Moisture-wicking fabrics keep you cool and dry, anti-odor technology keeps you fresh, and flatlock seams prevent chafing. This UA baselayer is built for heroic performance.
Click here to check out our Under Armour Boys' Alter Ego Shirts.
- Smooth, light HeatGear® Sonic fabric provides extreme comfort and compression without restriction
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- Signature Moisture Transport System wicks sweat away from the body to keep you cool, dry and light
- Anti-odor technology prevents the growth of odor causing microbes
- Smooth, flatlock seam construction prevents chafing and irritation
- Fabric: polyester/elastane
- Style: 1246520
- Under Armour
- Iron Man, Hulk, Spider-Man are property of �Marvel
Country of Origin: VietnamWeb ID: 20144696


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Job Openings
GreenPages is a leading cloud management consulting and integration firm that helps clients fully virtualize their environments and transform their datacenter and IT operations to effectively leverage the power of cloud computing. The company's deep technology expertise, broad engineering certifications, and vendor agnostic business model offer clients a strategic, cross-platform, proactive approach to designing, deploying, and supporting modern IT environments.
GreenPages offers comprehensive compensation & benefits packages, flexible schedules, and a place to grow your career in a collaborative, fast-paced and supportive environment. If you are looking for a place in which your contributions can make an immediate and important impact, we'd love to speak with you.
Contact us for more information on our Technology Solutions.
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Villa Lilla
from £396 /night help Price for guests, Nights approx:
from £396 /night help Price for guests, Nights approx:
Estimated nightly price based on a weekly stay. Contact the advertiser to confirm the total cost.
Villa / 5 bedrooms / sleeps 10
Availability Your dates are available
Villa / 5 bedrooms / sleeps 10
|Key Info
This is a highly desirable property – one of only a few private villas with pool, available for rent in the area.
The spacious villa is laid out over 3 floors.
Top floor: 2 bedrooms, 2 bathrooms
Luxurious and spacious master suite with large double bed and luxurious memory foam mattress and a large en suite bathroom containing bath and walk in shower. The bedroom opens out onto a large wrap-around terrace overlooking the pool and the lake below and a guest room with a double bed and en suite shower room. Both rooms have a balcony with stunning lake views.
Spacious guest suite with en suite shower room and balcony overlooking the lake and the mountains.
Ground floor: living area + 1 single study bedroom, 1 cloakroom
Main villa living area with open plan stylish kitchen and dining area, with 2 ovens, dishwasher and microwave. Clean lines, sophistication, light and stunning views are the order of the day here! The living area has 3 large patio doors, providing stunning lake views, a huge comfy sofa and large flat screen TV with SKY satellite. There is also a single study/bedroom & cloak room with sink and WC.
Basement: 2 bedrooms, 1 bathroom + double sofa bed in living area
Self contained unit with 2 twin bedrooms, shower room, open plan lounge/relax area. It has its own private entrance and parking with large patio doors and stunning mountain views. The basement can also be accessed via an internal staircase.
|Sleeps up to 10, 5 bedrooms
|Check in time:
|Check out time:
|Nearest beach
|Argegno 2 km
|Will consider
|Long term lets (over 1 month)
|Car advised
|Nearest Amenities
|500 m
|Nearest travel links
|Nearest airport: Milan Malpensa 72 km, Nearest railway: Como 20 km
|Family friendly
|Suitable for children over 5
|No pets allowed, No smoking at this property
Features and Facilities
|Internet access, DVD player, Sea view
|Private outdoor pool (unheated)
|Central heating, TV, Satellite TV, Wi-Fi available
|Kettle, Toaster, Iron, Hair dryer
|Dishwasher, Cooker, Microwave, Fridge, Freezer, Washing machine
|5 bedrooms, 5 bathrooms of which 3 Family bathrooms and 2 En suites
|Double beds (2), Single beds (5), Cots (1), Dining seats for 8, Lounge seats for 8
|Linen provided, Towels provided, High chair
|Private outdoor pool (unheated), Balcony or terrace, Private garden, BBQ
|Secure parking
|Further details indoors
Additional Information
The property has WIFI and is provided with a reading library and DVD library.
There is a large gas BBQ for guests to use.
There is a washing machine in the basement.
The access road is narrow and steep, so not suitable for minibus-type vehicles. Standard people carriers and normal cars are fine
A private chef and maid service are available on request.
|Further details outdoors
There are spacious grounds with grassed areas, as well as balconies and terraces. So plenty of space to sunbathe or play games.
The gated driveway has space for 2 cars and there is additional parking outside the basement apartment.
Private and sunny pool, sunbathing areas and car parking for several cars.
|Further details
Due to the high level of fixtures & fittings,a €500 euro refundable breakage deposit is payable on arrival.
The rental price includes all linens and towels. Additional towels are provided for the pool.
Payment can be made via cheque, bank transfer or Paypal (5% surcharge)
The Lake Como region
Lake Como has been famous and popular for centuries, due to its unrivaled beauty. It is still popular today for many more reasons: It is within striking distance of many interesting places - Milan, Monza, St Moritz and Lugano, to name just a few. It offers something for every type of holidaymaker from the sporty to chill-out to culture-vulture with water sports, golf, horse-riding, stunning villas and historic churches, shopping to die for (ask for our designer outlet guide), wine tastings, gourmet restaurants and some of the best pizzas you will ever taste at only €4 for a pizza margherita, you can't go wrong! It is also home to the island of Comacina and one of the most famous restaurants on the Lake, visited by everyone from Eisenhower to Clooney.
Argegno, 20km from Como
A popular destination for tourists, Argegno is situated in a large inlet on the western shore of Lake Como at the mouth of the Val d'Intelvi. It has a pleasant climate and is mild even in the winter months. With its' beautiful panoramic location, one can see from the headland of Bellagio to the north and as far as Nesso towards the south.
Argegno offers a surprising amount of facilities for a quaint lakeside fishing village – 5 good restaurants/pizzerias, 2 excellent wine bars (Enoteca and Bar Colombo), serving free snacks at aperitivo time every day. There are 2 banks with cash points and a small store. And you won't be able to resist Andrea's home-made ice creams (made with whatever is available fresh that day, including cucumber!). The scent of the bakery will draw you up the narrow alleyways to find fresh brioche (croissants) and bread, baked daily on the premises by Louisa. Buy fresh vegetables from Mario and ask him for one of his superb recipes – always served with smile and he speaks excellent English. If that wasn't enough, the village also now boasts a beautician and 2 hairdressers!
Argegno is also within striking distance of all Lake Como's treasures, as it is a main bus and ferry stop-off point for the rest of the lake. Villa Balbianello (Star Wars & James Bond) is just around the corner, Villa Carlotta a short ferry ride away, as are Bellagio, Menaggio and Varenna – get a centre lake ticket and visit all three in one day. The village is certainly of Roman origin, as it owes its' name to the consul Publio Cesio Archigene. At one time Argegno was part of a defensive system, which extended as far as the ancient villa of Lenno and the Isola Comacina to obstruct the passage of invaders. The village is certainly of Roman origin, as it owes its' name to the consul Publio Cesio Archigene.
At one time Argegno was part of a defensive system, which extended as far as Lenno and the Isola Comacina to obstruct the passage of invaders. The ancient centre of the village is very picturesque. It is crossed by the Telo stream and is divided into two parts, which are joined by an old stone bridge with a lancet arch.
It is possible to take a cable car up to Pigra (881 m), which is situated on a plateau with a beautiful view of the lake. From here it is possible to go on to the Valle della Camoggia, which is in the oasis of Argegno-Cima della Duaria, a conservation area. The road which runs along Val d'Intelvi also starts from Argegno and about 15 km along it one comes to Lanzo.
Things to see
The Sanctuary of Sant'Anna
This was built in the seventeenth century but it was subsequently renovated. Inside one can find stuccowork and frescoes from the seventeenth and eighteenth centuries.
The Oratory of San Rocco in Pigra
Built in the fifteenth century, it contains frescoes from 1662 signed by S. Pozzi.
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Help other travellers decide where to stay
Add your voice to the conversation about this holiday home and your review will appear on TripAdvisor too.Write a review
11 Jul 2014
"Stunning villa in a fabulous location"
Villa Lilla was the perfect place a week-long celebration of our 40th wedding anniversary with all our family and young grandson.The whole villa was really well presented and cared for, all equipment… More
Thank you for your comments. We are so pleased that everything went to plan fir this important anniversary and that the villa was perfect for all of your family.
3 Aug 2013
From the moment we arrived Beverley and Jonathan could not have been mot helpful.A week in Villa Lillla with the whole family was a birthday gift for my husband from our son - so we wanted it to be ve… More
We are delighted that you have enjoyed your stay with and hope to see you again next year.
25 Jul 2013
"Stunning view over lake como, it is true what they write!"
Thank you Beverley and Jonathan, we had a great stay at Villa Lilla.
Your welcome was Heartwarming and very informative.
Villa Lilla is a beautiful house on a wonderful location with stunning views.
Terras excelent, althaugh during summertime you need a parasol.
Livingroom and kitchen OK, nice view again. Kitchen equipment sufficient.
Sleeps 8 persons, masterbedroom great. 4 persons sleeps in the basement, might be a bit gloomy and dark, but use it for only sleeping it's OK.
Driving to VillaLilla needs some courage, it is really very steep, so bring a powerful car.
Shopping in Argegno, for bread and small stuff its nice, but if you want to cook a real meal, go for shopping at Bennet's shoppingcenter, Como Nord.
One might argue that that the price might be high during the high-season, but in comparison with other rentals this Villa is value for money.
This Villa is a good option for two small families.
We sure will come back, its a great place to stay!,
So glad that you enjoyed your stay with us. Thank you for your review.
29 Oct 2012
"Absolutely incredible Villa with hosts that go above and beyond!"
Absolutely incredible end to a European vacation- all made possible by Villa Lila. The views were breathtaking, like nothing I have ever experienced. The hike from the villa to the top of the mountain… More
22 Oct 2012
"Wonderful stay in Argegno at Lake Como"
We stayed one week in this fantastic villa above the pictures town Argegno. It was to cold to use the pool, but in summer it must be very nice to have a swim and at the same time viewing beautiful Lake Como.
The house is nicely furnished and you have the nice view from both living room and bedroom. The master bathroom was fantastic with a large bath.
Only minus is the steep road up to the house, but you get use to it. We were happy that we were driving our 4W car.
Make sure you visit Villa D´Este for a lunch or dinner at La Veranda, and have a walk in their park. Such a nice place. Can also recommend to visit Bellagio, Lenno, Mennagio, Tremozza, Como and of course Argegno
Thank you very much for taking the time to review the apartment. We are so glad that you had a wonderful holiday and we would love to see you again next year - book early though!
15 Sep 2012
"Fantastic peaceful & secluded villa with great view"
We spent a lovely peaceful extended family holiday at this villa. The Villa was peaceful, secluded and very comfortable.Quiet, secluded location. Immaculte villa with all amenities. Fantastic pool and… More
15 Sep 2012
"Excellent Villa in lovely spot high above the Lago Di Como"
Lovely secludesd villa in a small village high above the Lago Di Como. Vwery private, peacefull and quiet. Great privatre pool. Villa Lilla was bright, airy and very comfortable. Excellent amenities, kitchen very well placed and plenty of room.Pool very, very nice. Bedrooms bright and airy and fantastic view from master bedroom. Walk down to Argegno is a nice 20 minute stroll but going back up not for the unfit. Bevand Johnny could not be more helpful, excellent service and very friendly.
18 Jun 2012
"Amazing views and luxury finish!"
We had an amazing stay at this beautiful hill top villa. Beautiful views out across the lake while enjoying sitting by the pool. September was a great time to visit as quieter but still really warm (m… More
18 Jun 2012
"Just as expected and more!"
Great views, lovely villa, spotlessly clean, need a car to visit all the nearby attractions… More
18 Jun 2012
"Just as we expected, and more!"
Great views, lovely villa, spotlessly clean.
Lovely area, plenty of great places to visit, good restaurants, hire a car to get the best out of the area.
This advert is created and maintained by the advertiser; we can only publish adverts in good faith as we don't own, manage or inspect any of the properties. We advise you to familiarise yourself with our terms of use.
You're booking with
Beverley R.
- 4 Years listed
75% Response rate
Calendar last updated:10 May 2015
Based in Italy
- English
- French
- Italian
Payment accepted
Credit cards accepted
- Mobile
- +39 (0) 348 4108 544


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Calgarians mourn passing influential architectOne of Calgary's most influential architects and proponent of urban design died Saturday morning, sparking condolences and tributes from family, friends and local politicians.
Road Tolls Won't Solve Traffic WoesWriting in The Calgary Herald last week, Andrew Coyne advocated for road tolls in cities to alleviate traffic congestion. Simply, the argument is that by charging drivers you'll shift demand to another mode of transportation.
Break our addiction to parking lotsThere is a concept used in addiction studies known as "enabling." It points to a third-party force in one's life that encourages – enables – negative behaviour.


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COLUMBIA CITY — Masonic jurisdictions have recognized the sons of Masons who join the fraternity by giving them the title of Lewis.
Strangely, this is a custom that has remained unpracticed in the United States. This year marks a change in the Masons, or at least in Indiana and in Columbia City.
Two families have bestowed the Lewis Award on their sons.
Recently, the Jerry Yagel and Cliff Schlatter families presented the Lewis Award to their sons.
Jerry's son, Bob, presented the Lewis Award to his son Justin Yagel. Witnessing the event was Tim Yagel, cousin, and Jesse, uncle.
David A. Graves, 69, of Roanoke, Ind., passed away at 2:05 p.m. Saturday, June 2, 2012, at Parkview Regional Medical Center, Fort Wayne.
Born Nov. 19, 1942, in Allen County, he was the son of Deloss S. and Donna Belle (Swing) Graves-Gillam.
Mr. Graves graduated from Roanoke High School with the class of 1961. He was a lifetime resident of Roanoke, except for the time he served in the U.S. Air Force from May, 1961-1965.
Larry Robert Bills, 76, of Columbia City, died at home at 1:40 p.m. Saturday, June 2, 2012. Born on April 21, 1936, in Whitley County, he was the son of Charles Alfred and Thelma Odetta (Campbell) Bills.
A lifelong Whitley County resident, he attended Troy Center Grade School and Larwill High School.
He married Carolyn A. Miller in Fort Wayne on Jan. 21, 1961. She died in 2008.
Brown to serve as Whitley County Chamber of Commerce executive director
COLUMBIA CITY — The Whitley County Chamber of Commerce announced today the selection of Doug Brown to serve as the organization's new executive director.
"Former general manager of a local printing company and previous publisher of The Post & Mail newspaper, Brown brings great business experience and community connectivity to the position," said the county chamber in a press release.
Ben White and Jack Shipman field a ball in the infield.
A mangled up pile of rubble was all that was left after an RV flipped off the road near Collamer Monday night.
The Winnebago, that was driven by a local man, according to police, rolled on its top, nearly crushing the driver, on River Road near CR 950 W.
The driver was pinned with thousands of pounds of rubble above him. A tow truck was expedited and the man was extricated within minutes According to witnesses, the driver was speaking after the accident, though occasionally lost consciousness. He was airlifted to Fort Wayne.
U.S. Senate candidate Richard Mourdock, left, and U.S. Sen. Dan Coats,right, stopped paid a visit to C&A Tool Engineering in Churubusco Friday morning. They were greeted by company president Dick Conrow.
The senator and senatorial candidate were there, according to a company press release, to discuss the healthcare reform package proposed by President Barack Obama.
SOUTH WHITLEY — For 28 years Whitko High School has celebrated budding artists.
Under the tutelage of Walt Malicki, students have been awarded many championships and honors.
This year was no different.
Competing against high school artists in northeast Indiana and northwest Ohio, Rebekah Brenneman won the American Vision Award. Danielle Graves won Gold Portfolio.
Competing in the State Resolution contest, held at the Indiana State House, was Keaton Irwin and Ivory West. They received the Republic of China Awards.
Motorcycles made their way from Fort Wayne to downtown Columbia City for the 2012 Mayor's Ride on Sunday. The town square hosted vendors and motorcycle enthusiasts all to welcome the collective riders. Event organizers timed the ride to coincide with motorcycle safety month.
COLUMBIA CITY — Participants in Whitley County's Relay For Life took to the Indian Springs Middle School track, Saturday, for 24 hours in an effort to raise funds for cancer research.
Each lap took them one dollar closer to finding a cure. Partnering with the American Cancer Society, those participating in the event walked as survivors, caregivers or for those who lost their battle to cancer. To make special the memory of those lost to cancer, caregivers released balloons into the sky.


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This Saturday's federal election promises to be the most exciting in at least a decade. If you're undecided as to who to vote for or just can't wait until the first results dribble through, there's a plethora of ways to stay informed.
We take some time out from reviewing the latest GPSes to have a look around this year's Australian International Motor Show and find some cars we'd love to be driving, if we had a sack full of hundred-dollar bills.
Some big series are winding down in June on HBO Now, including "Game of Thrones" and "Silicon Valley." Fear not, the service will see some new series premieres later in the month.


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Conserve water by collecting up to 50 gallons of free rainfall to use later in your garden. The unique flat-back design save space, as it sits flush against a wall. Offering an authentic oak barrel appearance, the rain barrel includes a filter screen, hose shut off valve and dual overflows. Available in Woodgrain, Green or Tan.
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CHARLOTTE, N.C. -- Young Lim and his wife own the Gas and Go on Carowinds Boulevard.
I took over this business about five-and-a-half years ago. Me and my wife work seven days a week, 80 hours a week. We work here, said Mr. Lim.
Police say that over the weekend, someone invited their friends to the Gas and Go and didn't pay, stealing 800 gallons of gas.
Think about it -- $3,000 is a lot of money, said the owner.
The theft was caught on tape. The crooks rigged pump seven to keep running. One car after another pulls in and fills up, as seen on the video.
It took about an hour, and then they disappeared. And then they came back the next day.
The crime occurred right in front of everyone. The business was open. Other customers were pumping gas, clerks were around, even a Charlotte Mecklenburg police officer pulls in, but no one notices.
This is the guy coordinating, and he came into the store. So see, they are all in here, said Lim as he shows NBC Charlotte the security tape.
From the tape, it's obvious the suspects didn't try to hide. One of them even comes into the store to buy a pack of cigarettes.
Lim says this is a big hit to a small mom-and-pop store like his. He needs to order gasoline but says he doesn't have the money right now.
His loyal customers are angered by the crime.
I feel real bad because he's a cool dude. He's been friendly with me ever since I started coming to this store, said Wesley Chestnut.
Judy Closser agrees. It's terrible, these little mom-and-pops are just trying to make a living, she said.
Lim has provided police with the tape, so now they have good pictures of the suspects.
It needs to be stopped and I need some help, he said.
Since the end of last month, three other gas stations have been hit, including two Circle K's in East Charlotte. Police have not said if the cases are connected.
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Thieves rig Charlotte pump, steal 800 gal. of gas in plain sight
CHARLOTTE, N.C. -- Young Lim and his wife own the Gas and Go on Carowinds Boulevard.


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Luxury Residence: Elite Holiday Home
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Description from the owner
- Villa
- 4 bedrooms
- 4 bathrooms
- Sleeps 8
Bedrooms: 4
Bathrooms: 4
Sleeps: 8
Type: VillaLuxury Residence: Elite Holiday Home
Description from the owner
Classy Stylish Romantic ...
Overlooking Chalong Bay, our residence offers a stunning sea view in addition to a luxurious stay in a unique Thailand experience.
Our Residence is comprised of a spacious layout consisting of 600 square meters. Each 4-level private holiday home features comfortable and stylish dining and living areas, a fully equipped kitchen, 4 distinct bedrooms, a private lift between floors, an exclusive ground level swimming pool, and a rooftop whirlpool on the terrace overlooking the sea. We are discretely located on a private access road with provided security 24 hours a day.
Our residence has been hand designed by an Italian ...Read more
About the owner
About the owner
Almali R.
Almali R.
Response rate 95%
Response time A few hours
Calendar updated 4 days ago
Overall rating4.9 / 5.0 based on 17 reviews and 6 properties
Luxury Residence: Elite Holiday Home
Rawai, Phuket, Thailand
(Property location is approximate) ?
Additional Location Information
Almali residence is just steps from the sand and sea within walking distance, or few minutes drive, of the following places.
Our closer neighbor
Atmanjai Spa and Wellness Center
Atsumi Healing Center
(1 km. away) for the rejuvenation of your body and mind.
Other attractions
Big Buddha- One of the islands most important landmarks and a must see attraction marking the best 360-degree view of the island.
Wat Chalong- The largest and most revered temple on the island.
Phuket Zoo- Animal shows.
Phuket Aquarium- Featuring thousands of tropical fish and exotic marine creatures.
Phuket Town- Perfect for the bargain lover and a great place to sight see! Phuket Town is full of historical buildings, markets, local restaurants, trendy nightclubs, stores, shopping centers, and more.
5 minute drive
Rawai Beach- Home of countless fresh seafood and local restaurant options. Parallel to many more shops, massage parlors, and bars. Visit the Sea Shell Museum or the Sea Gypsy Village to shop through stalls of fresh fish caught only hours earlier.
Chalong Pier surrounded by restaurants and bars, many businesses in this area can help to organize boat excursions to islands, diving trips, fishing, and more.
Also within the 5 minutes radius is Kaneng Seafood: a classy seafood restaurant, "V set": an elegant beach club (O2), wine shops and bars, Villa Market shopping center, Tesco Lotus, 7-11 and minimarts, all local banks, and plenty of ATM machines located outside of the businesses along the road.
Phuket is a paradise for golf lovers. Below is a list of the many different courses suitable for all levels of players.
Pounaka (5-7 minute drive)- A 9 hole compact course offering night golf and exclusive practice facilities.
Phuket Country Club (15-20 minute drive)- An original 18 hole course with an additional newer 9 hole course.
Loch Palm Golf Course (20 minute drive)
Red Mountain (20 minute drive)- Voted as one of the top 3 most beautiful courses in Asia
Banyan Tree (40 minute drive)
Mission Hills (45 minute drive)
Blue Canyon (45 minute drive)- Voted the best golf course in Asia several years in a row offering a championship and a lakes course.
Member privilege access is granted to all of our guests at both Phuket Country Club and Blue Canyon Golf Club.
10 minute drive
Nai Harn Beach- known for its beauty, this is a popular beach with the locals. Located in close proximity to many more restaurants, shops, and bars in Nai Harn village.
Laem Prompthep a famous viewpoint located at the southern most point of Phuket. This stop is highly recommended for viewing sunsets.
Popular tourist areas in Phuket
For more beaches, restaurants, bars, entertainment, etc.
Kata (15 minutes)
Karon (20 minutes)
Patong (40 minutes)
Kamala (60 minutes)
The activities in Phuket are endless; spend your days swimming, diving, snorkeling, biking, kite surfing, paddle boarding, jet skiing, parasailing, or horseback riding around the island.
An array of exotic options such as Thai boxing, elephant trekking, monkey, crocodile, or snake shows, 4 wheeling in the jungle, and bungee jumping are also available.
In the evening, live music is played in numerous bars and clubs in addition to a few other popular shows in Phuket:
Phuket Fantasy
Siam Niramit
Simon Cabaret
Aphrodite Cabaret
There are many local hospitals and two international hospitals located nearby.
Bangkok Hospital and Phuket International Hospital both offer high quality service at international standards (including dental care).
Pharmacies are also plentiful and can be found on most main roads in town.
A metered taxi or private car can be found in town and around the beaches along with the infamous "tuk tuk" and motorbike taxi that often prove to be a popular and inexpensive choice. There are also a few local buses that connect beaches and shopping centers.
To rent a car or motorbike we recommend that you book through our resident manager for a quality vehicle. Please drive cautiously, as the roads in Phuket can be dangerous due to the high quantity of inexperienced drivers.
More About This Location
Beach or lakeside relaxation, Waterfront
Getting There
Nearest airport: Phuket International Airport
Nearest ferry port: Chalong Pier
Car is not necessary
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text:
CFO of the Year: Mark DeNicola
Mine closings opened door to career change
Mark DeNicola moved his family five times in seven years to take increasingly responsible roles at mining companies before becoming chief financial officer at Inspiration Coal Inc. in Knoxville, one of five cities his wife, Connie, had chosen as a desirable long-term home.
Not more than a year later, he wondered if he had made the biggest mistake of his life.
Inspiration Coal had a new South African owner with deep pockets, and the company had gone on a buying spree of mines in southeast Kentucky and Virginia. Tests on how much coal could be recovered at those sites, however, were disappointing. The union shop's costs, meanwhile, continued to increase. And then the price of coal plummeted.
When the parent company's CEO came to town and only Inspiration's president was invited to dinner, DeNicola became anxious. Later that night, DeNicola's boss called him to say the company was divesting of its North American operations.
"My heart sunk," he recalls. "I thought, 'I had it made out in Nevada … and I brought my family back east to a company that was now going to be defunct.' "
Time, however, was on his side. He and Inspiration's president were charged with selling the mines, setting their own severance dates, and promised two years' pay after their last days on the job.
DeNicola decided to change his career path.
The niece and nephew the DeNicolas had raised since they were elementary-school age were now in high school, and the couple did not want to disrupt their lives with another move.
The coal industry was being rocked by bankruptcies and closures. "All the people who pulled me along were now either acquired or merged out of existence," he says.
A newspaper advertisement from Cobble Personnel led him to what he thought would be a temporary job that would get him some diverse experience and local contacts. Instead that job evolved into a nearly 20-year career with family-owned Thermocopy of Tennessee and the honor of CFO of the Year from the Knoxville chapter of Financial Executives International.
'A pretty neat place'
Title: CFO and executive director, sales/marketing, Thermocopy of Tennessee
Age: 53
Education: Bachelor's degrees in accounting, business administration and economics; associate's degree, computer science, Thiel College, Greenville, Penn.
First post-college job: Setting up computer systems at an Amoco Minerals Co. coal mine, where he worked his way into an accounting role
Community service: Board of directors, Trinity Compassion Health Foundation of East Tennessee; fformer board of directors, Mercy Health Partners Foundation, Keep Knoxville Beautiful, Knoxville Chamber; former president, Greater Knoxville Tennis Association; former vice presidnet, Tennessee Tennis Association
Family: Wife, Connie; daughter, Elise, turns 13 this month
If shutting down Inspiration Coal had any silver lining it was that DeNicola got a taste for running the show. Not that he wasn't always a strategic planner.
Before entering Thiel College, a small liberal arts school not far from his native Brave, Pa. (population 400), DeNicola was determined to make the most of the opportunity.
"I wasn't a freshman who entered school and said, 'I don't know what to do.' I had my whole curriculum planned out through my senior year."
That planning enabled him to earn bachelor's degrees in accounting, business administration and economics, as well as an associate degree in computer science, within four years.
He hired on with Amoco Minerals Co. after graduation, setting up office computers at a coal mine the company had purchased in western Pennsylvania and "worked my way into a debits and credits type job."
Before too long he noticed that the engineers were the executives on the fast track. He gained their respect by writing return on investment programs for them, and earned a reputation as a financial go-to guy.
His career brought him to the coalfields of Kentucky, and while living in Middlesboro, Ky., he and his wife "fell in love with East Tennessee."
An offer to become a comptroller with Echo Bay Mines, which mined for gold in the western United States and Canada, however, postponed their settling down here.
Instead, the family headed for the Round Mountain Mine in the middle of nowhere, Nevada. DeNicola's responsibilities included accounting and inventory for the company town, which included a grocery store, medical clinic, restaurant and housing. "The only thing we didn't do was pay in scrip," he says.
When the offer from Inspiration Coal came to head back east, the family didn't hesitate.
Just three years later, however, DeNicola was looking for work. He earned his certifications in public and management accounting. Still, he was often the bridesmaid, but not the bride for prospective employers. "I would get down to the last two or three finalists and I would be selling myself against someone my age who had 20 years in that industry," he remembers.
When he saw Cobble Personnel's ad for an executive search division, he picked up the phone. He remembers it was a Thursday. The recruiter told him she had an employer that was looking for someone with his qualifications, a family-owned company in which the father was retiring and wanted someone to be the "right hand" to his son.
Who is the company? he asked. Thermocopy, she replied.
What do they do? Sell and service copiers, specifically Ricoh and Minolta brands.
Yellow flags popped up. DeNicola equated, quite candidly, copier salesmen with used car salesmen and the only brands which he had ever heard were IBM and Kodak.
How big is it? Thermocopy's annual revenues were about $5 million. DeNicola had worked for organizations with annual cash flow 10 times that amount.
Where is it? On Sutherland Avenue, which he found during a reconnaissance for his interview was peppered by low-income housing and crumbling commercial sites.
He rationalized that the interview wouldn't be a total waste of time — it was good to practice and he might develop some contacts to help him with his job search.
It didn't take long for his thinking to change.
"When I hit the door of the business, I just felt an energy here," he recalls. "It felt good." He clicked with father-and-son owners Randall and Steve Sumner. "I walked out thinking, 'Wow, this is a pretty neat place.' "
The Sumners liked DeNicola too. The Cobble recruiter told him they were going to make him an offer — a salary of about 35 percent of what he'd earned at Inspiration Coal.
DeNicola took the leap, figuring it was a short stint that would prepare him for a better opportunity.
"Upon my severance date (from Inspiration Coal) I was being paid two years' salary, so in the back of my mind I thought anything I make here is a like a bonus to me. I will be learning a new industry. I will be learning a wholesale/retail business, which is a whole different segment of industry, and in two years I am out of here. And here I am almost 20 years later."
'Bigger thinking'
Founded: 1964
Business: Provider of office document management products and services
Offices: Knoxville, Johnson City
Employees: 60
Annual revenues: $15 million
Notable clients: Covenant Health, Oak Ridge National Laboratory, Y-12 Nuclear Security Complex
Thermocopy President Steve Sumner says he and his roughly 60 colleagues had "grown up in the company. We were kind of myopic, and Mark brought much bigger thinking to the operation. He has been instrumental in radically changing the company."
DeNicola brought a corporate mindset to the company, introducing strategic planning and forecasts to the organization. Sumner says like his father, Randall, DeNicola is an "accountant by training and a salesman at heart."
Rather than cut his teeth within Thermocopy's sales organization, DeNicola in 1998 started a branding and design firm. DeNicola grew the subsidiary to $800,000 in sales, by convincing small business owners and finance executives their investment in branding and design would pay for itself over 10 years.
"That got me my first taste of sales," DeNicola says. "It was an intangible product, and if you can sell an intangible product you can sell a product that everyone needs."
Soon after the terrorist attacks of Sept. 11, 2001, and the subsequent economic uncertainty, Thermocopy closed the division and DeNicola became executive director of Thermocopy's sales and marketing staff.
"It was the best move we ever made," Sumner says.
DeNicola's skill at making the financial case for Thermocopy's services resonated with customers who, particularly in recent years, have looked to better information management processes and equipment to cut their own operating costs. Thermocopy responded by introducing less expensive multifunctional machines and features that help reduce waste.
Thermocopy evolved from a copier services and sales company to one that provides the infrastructure, whether hardware or software, to move information through organizations. "Thermocopy denotes old technology but we have so much brand equity in this area, we can't just walk away from it," DeNicola says. "We put a lot of effort to get people to understand that we do this other stuff too."
The company also took note on how new regulations were affecting customers — including Sarbanes-Oxley and HIPPA — and provided solutions.
Within the last three years, Thermocopy signed — and in one case renewed — contracts with the region's top employers — the Y-12 Nuclear Security Complex, Oak Ridge National Laboratory and Covenant Health.
While helping local organizations reduce costs and become more efficient, DeNicola also created a program to help Thermocopy become more environmentally responsible, that staff then rolled out to customers and ultimately the community under the name GoGreenET.com. The Business Journal now administers the GoGreenET website, social media presence and annual awards program to highlight organizations' green achievements. Thermocopy remains a partner, and KUB and the Knoxville Chamber have joined the effort.
"This is where we can actually, as part of our normal business plan and just a little more effort, not only make us better, but make our clients better too," DeNicola says. "Whether you believe in global warming or not, it's just a good thing to do and makes business sense."
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11.08.06 - By MARLON BERNARDINO: SOMEBDOY should have warned Filipino-American Brian Viloria before the fight, a hungry man doesn't drink a "Hawaiian Punch." Mexican Omar Niño Romero, fighting for title for the first time in his 11-year career, outworked Viloria to win by unanimous decision and capture the World Boxing Council (WBC) light flyweight belt Thursday night (yesterday morning in Manila) at the Orleans Hotel and Casino in Las Vegas, Nevada..
"I came here to win," the 30-year-old from Guadalajara, Mexico said. "I didn't come here to do anything else but win this title."
Romero busied himself sticking his jabs on Viloria's face and landing uppercuts and left hooks.
When it was over, the judges had it 118-110, 117-112, and 117-11.
"After four rounds, I knew I had him," said Romero, who fought outside of his mother land for the first time. He improved his record to 24-2-1, with 10 knockouts.
The new champion landed 245-of-778 punches (28-percent) while Viloria could only land 113-of-398 blows (28-percent) according to CompuBox statistics. It was Viloria's first loss in 20 bouts.
"I fought a stupid fight tonight," Viloria said. "I was in shock right now. I don't know what to do. It's just a shock."
Viloria's not the lone big name to suffer from the hands of Romero.
Jorge Arce, the reigning WBC flyweight champion, was stopped by Romero in the first round 10 years ago. The fight will be replayed on Solar Sports today at 9 p.m.
Meanwhile, Super flyweight Diosdado "The Prince" Gabi (27-3-1, 19 KOs)from Davao City, Philippines impressively demolished three-time world champion Mauricio Pastrana (32-7-2, 20 KOs), dropping Pastrana twice in just 96 seconds. (MARLON BERNARDINO)
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WILMINGTON — Hurricane Arthur has been upgraded to a Category 1 storm, yet forecasters are still not expecting the first hurricane of the season to inconvenience most Robeson County residents over the holiday weekend.
The National Weather Service in Wilmington is forecasting that the storm would make landfall at 6 p.m. Thursday, and by 8 a.m. on the Fourth of July will have moved off of North Carolina's northern banks.
"By 8 p.m. on Friday it will already be 22 miles off of the New Jersey shoreline, if that gives you an idea of how fast this is moving," said Steve Pfaff, a meteorologist with the National Weather Service.
While the outer banks and North Carolina coast are currently projected to experience sustained 60 mph winds and up to six inches of rain, Pfaff says that the southeast side of Robeson County will likely see an inch to half an inch of rain tonight and Friday morning, with little in the way of wind.
"The rainfall in Robeson County will drop significantly by Friday morning," Pfaff said Thursday. "This isn't going to be one of those storms that lingers."
The National Weather Service is recommending caution be used by people traveling toward the North Carolina coast, as the forecast is calling for flooding and a risk of tornadoes in the coastal Cape Fear area.


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'Sin City' no more
HONOLULU—Part of the reason Olongapo was included in the Philippine itinerary of the recent trade mission from Hawaii was that the city has become an outstanding model of local development after its previous long-standing image as a "City of Sin." The trade mission was looking for Philippine communities outside Metro Manila interested in business partnerships with the Honolulu-based Filipino Chamber of Commerce in its future missions to promote closer Hawaii-Philippines economic relations.
The trade mission also recognized that Subic is a potential retirement home for thousands of Filipino elderly who retire every year but cannot afford the prohibitive costs of retiring in the United States. Subic offers the amenities of a developed country while providing a familiar home atmosphere. Even non-Filipinos, particularly the Japanese, want to retire in the Philippines where the cost of living is more affordable than in their home countries.
Dr. Dean Alegado, my host and former faculty colleague at the University of Hawaii at Manoa, who has opted to retire in his native Olongapo, gave me a quick tour of the city as it looks today, including the once infamous R.M. Avenue just outside what used to be the US naval base at Subic Bay. Now a vibrant economic-zone community resembling "Little America" that is able to compete globally with its relatively developed socioeconomic infrastructure, Olongapo exudes an energy of entrepreneurship and vitality as the first Freeport City in the Philippines.
Of course, the visitor would be unlikely to miss the familiar "Gordon brand" of leadership displayed all over Olongapo. It is one of the most enduring examples of durability and continuity in Philippine politics. Political dynasties come and go but the "Gordon Knot" seems unbreakable and destined to last forever and a day in Philippine political memory.
The original patriarch, James Gordon, known as "the father of Olongapo City," was assassinated in 1967. But his name and mantle of leadership have passed on since then to a string of Gordons—his widow Amelia, older son Richard or Dick, Dick's wife Kate, and younger son and namesake James or Bong, currently the city's mayor. While there, I was already hearing loud whispers that after Bong's term expires, his wife Anne will be a "shoo-in" as his successor.
Politics thrives in the symbolism of memory. The late Mayor Gordon is enshrined as Olongapo's "first paladin to fight against political 'bossism.'"
He was a vigorous opponent of illegal logging in the watershed areas of the community and a firm advocate for land titles for city residents who did not own the lots that they occupied.
Bong Gordon, a musical artist to boot, has in effect become not just a son anymore but likewise the father of modern Olongapo. He is imbued with the ethics of hard work and competitiveness. His motto for running the booming city is "Fighting for Excellence."
He proudly showed the trade mission delegates the "symbols of progress" under his watch, ranging from a day care center in City Hall itself for children of employees to state-of-the-art health facilities.
Supporting institutions to promote education, expanding resources for conventions and meetings, increasing library resources and initiating "best practices" in other public endeavors are all part of Bong Gordon's visionary agenda. He is a proactive mayor determined to achieve the "pivotal transformation" of Olongapo from a former "Sin City" to a "topnotch destination" for both foreign and domestic visitors. Articulate and aggressive, he shows that his politics is about "winning and prevailing, amidst the odds." He has become a paragon in his own right.
It is hoped that increasing political democratization is also part of Bong Gordon's agenda. Expanding political participation, especially among the younger generations of leaders and citizens who will take over, will certainly boost further the stock of Olongapo as a model city for the Philippines and exemplar for good governance that we can all be proud of.
A Filipino trade mission delegate from Hawaii, Dr. Belinda A. Aquino is professor emeritus at the University of Hawaii at Manoa, where she served as professor of political science and Asian studies as well as director of the Center for Philippine Studies for 35 years.
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A Print-out from www.socialstyrelsen.se
Published: 2010-02-16 17:23
This is part of Rare diseases.
Diagnosis: Wiskott-Aldrich syndrome
Synonyms: --
Publication date: 2013-03-12
Version: 4.0
Wiskott-Aldrich syndrome (WAS) is a hereditary immune deficiency disorder (a primary immunodeficiency), which was first described by German physician Alfred Wiskott in 1937, and later by American paediatrician Robert Anderson Aldrich in 1954.
As a rule the syndrome only affects boys, and in its classic form it is characterized by a deficiency in blood platelets (thrombocytes), combined immune deficiency, and allergies.
There are also other forms of the disorder with fewer and less pronounced symptoms. Although the aetiology of these disorders is the same as in the classic form of the syndrome, their only or dominant characteristic is thrombocyte deficiency.
Approximately ten individuals in Sweden have been diagnosed with Wiskott-Aldrich syndrome. Approximately 1 boy per 300,000 is born with the condition, meaning that in Sweden one boy with Wiskott-Aldrich syndrome is born about every three years.
The cause of the syndrome is a mutation in a gene known as WASP, located on the short arm of the X chromosome (Xp11.4-p11.21). The gene was identified in 1994, and it codes for (regulates the production of) a protein named WASp. This protein delivers information from the cell surface to the cytoskeleton. The cytoskeleton is a kind of protein network that acts as a scaffold inside the cell, helping to maintain cell shape, and also enabling cell locomotion and mobility within the cell. WASp only exists in the cells of the blood system.
Mutations of the WASP gene can either cause complete lack of WASp or defective protein. The symptoms therefore vary greatly among individuals. Moreover, a full understanding of how specific mutations lead to the various symptoms is complicated by the fact that a few boys with a mutation that alters WASp function also have one or several other mutations which, in part, repair the gene.
If there is no WASp, many blood cells' functions are disturbed. For example, cell formation and division are affected, and the cells' ability to change shape in various immune defence reactions is impaired. The blood platelets also break down more rapidly than normal.
In the classic form of Wiskott-Aldrich syndrome no WASp is produced. In milder, less typical forms of the syndrome, however, there may be small amounts of defective protein. Another mutation that has the effect of constantly activating the WASP gene has also been described. A continuously active gene causes a completely different range of symptoms than if the protein is missing or defective. Instead of having a thrombocyte deficiency, children with a constantly active gene are deficient in the white blood cells known as neutrophil granulocytes.
A very rare form of Wiskott-Aldrich syndrome is caused by a mutation in the gene WIPF1, located on chromosome 2 (2q31.2). This gene codes for the protein WIP (WASp-interacting protein), which stabilises WASp. WIP deficiency causes breakdown of WASp, leading to very low levels or complete absence of this protein. The symptoms caused by a WIPF1 mutation are therefore similar to those associated with severe forms of Wiskott-Aldrich syndrome.
Wiskott-Aldrich syndrome is caused by a mutated gene located on the X chromosome, which is one of the chromosomes determining sex. Men have one X chromosome and one Y chromosome, while women have two X chromosomes. Inherited X-linked recessive disorders usually occur only in men, being passed down via a healthy female carrier who has one normal and one mutated gene. Sons of female carriers of a mutated gene run a 50 per cent risk of inheriting the disease and daughters run the same risk of being healthy carriers of a mutated gene. A man with an inherited X-linked recessive disease can not pass it on to his sons, but all his daughters will be carriers of the mutated gene.
The syndrome can also be caused by a new mutation. This means that the genetic mutation occurs in an individual for the first time and is not inherited from either parent. Consequently, parents with a child with a new mutation generally do not have an increased risk of having another child with the disorder. However, the new genetic mutation will be hereditary and an adult with this mutation risks passing on the mutated gene to his/her children. In Wiskott-Aldrich syndrome the situation is special as the new mutation has often occurred in the mother of an affected boy. As women have two X chromosomes the mother will not be affected, but all her sons have a 50 per cent risk of having the disorder.
The very rare form associated with a WIPF1 mutation has an autosomal recessive pattern of inheritance, meaning that both parents are healthy carriers of a mutated gene and that girls may also be affected. In each pregnancy, the risk that the child will be affected is 25 per cent.
All individuals with a mutation in the WASP gene, which causes the gene to produce no or defective protein, have bleeding problems. Individuals with Wiskott-Aldrich syndrome have an abnormally low blood platelet (thrombocyte) count, a condition known as thrombocytopenia, and the platelet function is also disturbed. This condition manifests as an increased risk of bleeding and poor blood coagulation. The first bleeding episodes appear as early as in infancy, and may occur in many different places, including the nose, gums, intestines, and skin. In the skin, the bleeding is visible as small red spots (petechias) or large bruises. However, the most common type of bleeding in infancy is intestinal bleeding. Severe bleeding from scrapes or cuts is another symptom of inadequate coagulation. When there is internal bleeding, for instance in the brain, liver, or spleen, the blood loss and other symptoms may be serious or even life-threatening.
Only boys who have no production of WASp protein are affected by the classic form of Wiskott-Aldrich syndrome, which is characterised by many and severe infections. In Wiskott-Aldrich syndrome, the immune deficiency affects both the B and T lymphocytes, and is therefore classified as a combined immune deficiency. Lymphocytes are a type of white blood cells that play a key role in our ability to fight off infections.
B lymphocytes protect us against bacterial infections, and their main function is to produce antibodies (gamma globulin). T lymphocytes primarily protect us against viral, fungus, and parasitic infections. They also regulate and coordinate our immune defence.
An individual with Wiskott-Aldrich syndrome will usually have normal numbers of T lymphocytes, but as they do not function properly, he will, for example, be more susceptible to fungal and viral infections. The number of B lymphocytes is also usually normal, but they lack the ability to produce antibodies against the polysaccharide capsules that surround certain bacteria. This leads to infections caused by bacteria such as Hemophilus influenzae and Pneumococci, which cause ear infections, pneumonia, meningitis, and septicaemia (blood poisoning). The infections begin around the age of six months, when the newborn has exhausted the antibodies received transplacentally from the mother. The immune function then tends to decline over the years, with infections becoming more frequent and more serious.
Various allergies appear early in children with Wiskott-Aldrich syndrome. Eczema is very common. In infants the symptoms resemble nappy rash, but the condition is often considerably more serious. In somewhat older children, eczema often appears around the elbows, wrists, throat, and the backs of the knees. There is itching and often a great deal of irritation, and complications in the form of bleeding and infections may arise. Other common allergies include asthma, food allergies, and hay fever.
In almost half of the older boys and men with Wiskott-Aldrich syndrome autoimmune reactions are common. They arise when the immune defence system manufactures antibodies directed against the body itself. The cause of these reactions is still unidentified. Examples of autoimmune reactions in Wiskott-Aldrich syndrome are episodes of high fever unrelated to an infection, and new rashes in conjunction with swollen, painful joints. Sometimes an autoimmune reaction affecting the thrombocyte function exacerbates the thrombocyte deficiency.
There is a raised risk of malignancies in Wiskott-Aldrich syndrome, and it increases with age. These diseases often attack the immune system in the form of leukaemia or cancer of the lymph glands (lymphoma).
The possibility of Wiskott-Aldrich syndrome should be considered in all forms of thrombocytopenia in men and boys. Sometimes individuals with milder forms of Wiskott-Aldrich syndrome are not diagnosed until symptoms other than bleeding problems, such as autoimmune reactions, have occurred.
When there is a suspicion of Wiskott-Aldrich syndrome, the thrombocytes are investigated first. The number and size of thrombocytes in the blood can be analysed in a normal blood test. Not only is the thrombocyte count low in Wiskott-Aldrich syndrome, but the platelets that do exist are typically very small.
In somewhat older children with Wiskott-Aldrich syndrome, there are clear functional deviations of the immune system, including abnormal antibody development, poor T lymphocyte function and abnormal levels of immunoglobulins. IgG antibodies are usually within the normal range, IgM antibodies are slightly decreased, while the levels of IgA and particularly IgE antibodies are elevated.
The diagnosis can be confirmed either through DNA analysis or by analysing the WASp protein inside the cells of the immune system. At the time of diagnosis the family should be offered genetic counselling. Carrier and prenatal diagnostics, as well as pre-implantation genetic diagnostics (PGD) in association with IVF (in vitro fertilization), are available in families where the mutation is known.
When a boy has been diagnosed with Wiskott-Aldrich syndrome, there are several possible treatment alternatives. The treatment of choice is haematopoietic stem cell transplantation (bone marrow transplantation), as it is the only treatment that can cure the disorder. Other measures primarily provide symptomatic relief and decrease the risk of infections. Treatment has improved in recent years but complications such as cancer and severe bleeding darken the prognosis, and most untransplanted boys with the classic variant of Wiskott-Aldrich syndrome will not reach adulthood.
Consequently, the possibility of stem cell transplantation should always be considered. The most important factor for successful transplantation is that the procedure is carried out early, preferably in the first few years of life. If the boy has healthy siblings, they should be tested to see if they have the same tissue type (a procedure known as HLA typing) and could thus serve as bone marrow donors. The results of stem cell transplantations when the donor is an HLA-identical sibling are in general very satisfactory. Most of these transplants are successful and result in a total cure of boys with Wiskott-Aldrich syndrome. If there is no sibling with identical tissue type, donors should be sought in a donor registry. The prognosis is equally good with a transplant from an unrelated donor who has the same HLA type as the recipient as when the donor is a sibling - provided that the transplant takes place early in life. The results are less satisfactory when the donor is a family member whose tissue type is only partly compatible with that of the recipient. In such cases, other forms of treatment should be considered. Further information about donors and the transplant procedure is found under the heading "Hematopoietic stem cell transplantation" below.
One important aspect of the treatment of Wiskott-Aldrich syndrome is the prevention of severe bleeding, particularly cerebral bleeding, which may be immediately life-threatening or may cause severe neurological damage. Young boys may need to wear a padded helmet to prevent blows to the head, and as they grow older they should avoid sports and activities with a high risk of injury.
An individual with Wiskott-Aldrich syndrome who begins to bleed heavily should be hospitalised, as special medication or a thrombocyte transfusion may be necessary to help the blood coagulate. Many serious viral infections with a systemic impact, such as influenza, also increase the risk of bleeding, which often necessitates thrombocyte infusion.
The spleen is an abdominal organ, and one of its functions is to serve as a blood filter. In Wiskott-Aldrich syndrome, the spleen filters out the abnormally small thrombocytes and destroys them, leading to thrombocyte deficiency. By removing the spleen, it is possible to normalize the level of thrombocytes in the blood, although the platelets will still be small and function poorly. It has previously been a common practice to remove the spleen in boys for whom no suitable bone marrow donor has been found. However, this intervention is currently not recommended as it has been shown to increase the mortality rate in these boys.
It is vital to take all infections seriously and to treat them early. Antibiotics should be given in all cases of bacterial infection. Special antibiotics may be required in cases of unusual infections. If infections recur at close intervals, continuous treatment for months or years may be necessary.
All patients with Wiskott-Aldrich syndrome require intravenous immunoglobulin substitution (gamma globulin) to combat infection. Immunoglobulin is a concentrate of antibodies drawn from the plasma of several blood donors. The blood from each donor is carefully tested to preclude infections such as hepatitis and HIV. Blood plasma is treated to eliminate risks from viruses or bacteria. The result is a liquid containing purified IgG antibodies as well as very small quantities of IgA and IgM antibodies. As immunoglobulin is a plasma product, there cannot be a 100 per cent guarantee that no contagious substances will be transferred. However, with the procedures and blood donor tests used today, the degree of safety is very high. The number of bacterial infections is substantially reduced with the addition of a correctly-adjusted dose of immunoglobulin in boys with Wiskott-Aldrich syndrome. As a consequence, the risk of corollary tissue damage from repeated infections also decreases.
Immunoglobulin is either administered as an intravenous infusion or as a subcutaneous injection (under the skin). The first alternative is to be preferred in patients with Wiskott-Aldrich syndrome in order to avoid bleeding in the skin. The added antibodies are gradually broken down, so the treatment has to be repeated at intervals of about three weeks or more often if needed.
Eczema is very common in patients with Wiskott-Aldrich syndrome. It is treated primarily with topical hydrocortisone cream, while skin lotions and oil are used to prevent skin dehydration. Anti-itching medications may also be needed, especially at night. In serious cases of eczema, allergy tests may reveal the need to exclude certain foodstuffs from the diet.
Hay fever and asthmatic conditions are treated as they would be in otherwise healthy individuals, with bronchodilators and antihistamines.
Autoimmune reactions are treated to ease the symptoms. Because the aetiology of these reactions is unknown, preventive intervention is not possible.
All blood cells are produced from blood stem cells (haematopoietic stem cells) in the bone marrow. Blood-forming stem cells can develop into red blood cells (erythrocytes), different kinds of white blood cells including lymphocytes and blood platelets (thrombocytes). In a stem cell transplantation a sick person's bone marrow is replaced with that of a healthy person. To optimise the chances of successful transplantation, the recipient of the marrow should be as free from infection as possible and in good physical condition. For this reason, it is important to carry out the transplantation at an early stage. The intervention itself is fairly simple, but the preparations, aftercare and major risks make it a highly demanding procedure.
In order to carry out a stem cell transplantation, a donor must be found whose tissue type (HLA type) matches that of the recipient. Ideally the tissue type should be identical. Tissue type is inherited from both parents, and each child has a 25 per cent chance of having the same tissue type as a sick sibling. The optimal solution is to transplant stem cells from an HLA-identical, healthy sibling. If this is not possible a suitable donor may be located in national and international bone marrow donor programmes or in stored, frozen blood from umbilical cords. The "Tobias Registry" in Sweden contains approximately 40,000 registered voluntary donors, and the names of more than 19 million other donors can be found in registers outside Sweden.
Preparatory measures are needed to help the new stem cells engraft and minimise the risk of diseased cells attacking the new donor cells. The recipient of the transplanted cells is treated with chemotherapy. This treatment can be extremely demanding as chemotherapy also impairs the barrier function of the mucous membranes. There is a major risk of developing serious infection and for this reason the child needs to be kept in isolation for a period of weeks, or sometimes months prior to and after the transplantation.
In a blood stem cell transplantation, bone marrow is drawn from the donor's hip bone and is then administered to the recipient via drip, directly into the bloodstream, much like in a blood transfusion. Blood stem cells can also be collected from the donor's blood. The blood is then filtered in a special kind of centrifuge which separates the stem cells from the rest of the blood, which can then be returned to the donor. A third option is to use umbilical cord blood from newborns, which is particularly rich in blood stem cells. The blood of newborns has very high levels of blood stem cells and the small amount of blood remaining in the umbilical cord of a healthy newborn can be frozen and saved for later transplantations.
Regardless of their source, the transplanted blood stem cells find their way into the bone cavities of the recipient, and grow in the bone marrow to supply the child with a new immune system.
Be attentive to hand hygiene. Avoid smoky or dusty places, and large crowds of people at times when infections are common.
Be especially careful with regard to food and hygiene during trips abroad as they often increase contact with new types of bacteria. Consult a doctor about what sort of medication and medical supplies should be taken on the trip. For maximum protection against infections, gammagobulin should be administered as close to the time of departure as possible. If immunoglobulin and the infusion equipment are taken abroad, the customs authorities will require a certificate. An information letter in the appropriate language as well as contact details of the attending physician in Sweden should also be taken.
Air humidifiers easily spread bacteria and fungus. If a humidifier is necessary, it should be regularly disinfected with bleach.
Diagnostics, assessment and treatment are provided at the Queen Silvia Children's Hospital, Department of Paediatric Immunology, SE-416 85 Gothenburg, Sweden.
Professor Anders Fasth, The Queen Silvia Children's Hospital, SE-416 85 Gothenburg, Sweden. Tel: +46 31 343 40 00, fax: +46 31 84 30 10, email: email@example.com
Chief physician Vanda Friman, Infection Clinic, Sahlgrenska University Hospital/Östra, SE-416 85 Gothenburg, Sweden. Tel: +46 31 343 40 00.
PIO (Primary Immunodeficiency Organization) organises regular lectures and information meetings on immunodeficiencies for people with the disease and their relatives. PIO arranges an annual weekend camp for children and with primary immunodeficiency disorders and their families. At regular intervals, PIO and the Nordic immunodeficiency associations organise joint meetings over a few days. They offer excellent opportunities for learning, and exchanging information. For further information contact PIO. Find address under "Organizations for the disabled/patient associations" below.
IPOPI, the International Patient Organisation for Patients with Primary Immunodeficiencies, of which PIO is an affiliate, arranges a conference in conjunction with a biennial international medical conference for doctors and nurses interested in immunodeficiencies. IPOPI conferences are conducted in English. For further information, contact PIO, under "Organizations for the disabled/patient associations."
Ågrenska is a national competence centre for rare diseases and its families' programme arranges stays for children and young people with rare diseases and their families. Ågrenska is open to families from the whole of Sweden and focuses particularly on the needs of children and young people with rare diseases. Every year a number of adults with rare diseases also visits Ågrenska. Information is available from Ågrenska, Box 2058, SE-436 02 Hovås, Sweden. Tel: +46 31 750 91 00, fax: +46 31 91 19 79, email: firstname.lastname@example.com, www.agrenska.se.
PIO, The Primary Immunodeficiency Organisation in Sweden, Mellringevägen 120 B, SE-703 53 Örebro, Sweden. Tel: +46 19 673 21 24, email: email@example.com, www.pio.nu.
SLIPI, Swedish Physicians' Association for Primary Immunodeficiencies organises meetings and conferences, www.slipi.nu.
SISSI, Swedish Nurses' Association for Primary Immunodeficiencies.The association publishes a worksheet and has regular conferences for members. In alternate years this is organized in collaboration with ESID, IPOPI and INGID, www.sissi.nu.
ESID, European Society for Immunodeficiencies.
The Society has regular international conferences and summer schools for doctors and researchers, www.esid.org.
INGID, International Nursing Group for Immunodeficiencies. The Group arranges international meetings in collaboration with ESID and the international patient organization IPOPI, www.ingid.org.
Research on Wiskott-Aldrich syndrome is currently ongoing in the US and Germany examining, among other things, the function of WASp (Wiskott-Aldrich Syndrome Protein). Gene therapy is also under development.
Contact persons are Luigi D. Notarangelo, Division of Immunology and The Manton Center for Orphan Disease Research, Children's Hospital, Harvard Medical School, Boston MA 02115, USA, and Klaus Schwarz, Transfusion Medicine, University of Ulm, Helmholzstr. 10, D-89081 Ulm, Germany.
Short summaries of all the information texts in the Rare Disease Database of the National Board of Health and Welfare are available as leaflets, in Swedish only. They can be printed out or ordered by selecting the Swedish version of each text, and then clicking on the leaflet icon which will appear under "Mer hos oss" in the column on the right-hand side.
IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, 5th Edition, USA 2013. This book may be downloaded as a PDF file from the organisation's website, http://primaryimmune.org/idf-publications.
The material below can be ordered from PIO (Primary Immunodeficiency Organization). See contact information under "Organizations for the disabled/patient associations etc." Unless otherwise mentioned, in Swedish only.
Albert MH, Bittner TC, Nonoyama S, Notarangelo LD, Burns S, Imai K et al. X-linked thrombocytopenia (XLT) due to WASP mutations: Clinical characteristics, long-term outcome and treatment options. Blood 2010; 115: 3231-3238.
Al-Herz W, Bousfiha A, Casanova JL, Chapel H, Conley ME, Cunningham-Rundles C et al. Primary Immunodeficiency Diseases: an update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency. Front Immunol 2011; 2: 54.
Aldrich RA, Steinberg AG, Campbell DC. Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics 1954; 13: 133-139.
Ariga T, Nakajima M, Yoshida J, Yamato K, Nagatoshi Y, Yanai Fet al. Confirming or Excluding the Diagnosis of Wiskott-Aldrich Syndrome in children with thrombocytepenia of an unknown etiology. J Pediatr Hematol Oncol 2004; 26: 435-440.
Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C et al. WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity. J Exp Med 2011; 208: 2033-2042.
Davis BR, Dicola MJ, Prokopishyn NL, Rosenberg JB, Moratto D, Muul LM et al. Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome. Blood 2008; 111: 5064-5067.
Facchetti F, Blanzuoli L, Vermi W, Notarangelo LD, Giliani S, Fiorini M et al. Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome. J Patol 1998; 185: 99-107.
Filipovich AH, Stone JV, Tomany SC, Ireland M, Kollman C, Pelz CJ et al. Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program. Blood 2001; 97: 1598-1603.
Galy A, Thrasher AJ. Gene therapy for the Wiskott-Aldrich syndrome. Curr Opin Allergy Clin Immunol 2011; 11: 545-550.
Gennery AR, Slatter MA, Grandin L, Taupin P, Cant AJ, Veys P et al on behalf of members of European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency. Long Term Survival and Transplantation of Haematopoietic Stem Cells for Primary Immunodeficiencies; Report of the European Experience 1968-2005. J Allerg Clin Immunol 2010; 126: 602-610.
Kajiwara M, Nonoyama S, Eguchi M, Morio T, Imai K, Okawa H et al. WASP is involved in proliferation and differentiation of human haematopoietic progenitors in vitro. Br J Haematol 1999; 107: 254-262.
Lanzi G, Moratto D, Vairo D, Masneri S, Delmonte O, Paganini T et al. A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP. J Exp Med 2012; 209: 29-34.
Lorenzi R, Brickell PM, Katz DR, Kinnon C, Trasher AJ. Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis. Blood 2000; 95: 2943-2946.
Notarangelo Ld, Miao CH, Ochs HD. Wiskott-Aldrich syndrome. Curr Opin Hematol 2008; 15: 30-36.
Ozsahin H, Cavazzana-Calvo M, Notarangelo LD, Schulz A, Thrasher AJ, Mazzolari E et al. Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation. Blood 2008; 111: 439-445.
Savoy DN, Billadeau DD, Leibson PJ. Cutting edge: WIP, a binding partner for Wiskott-Aldrich syndrome protein cooperates with Vav in the regulation of T cell activation. J Immunol 2000; 164: 2866-2870.
Schurman SH, Candotti F. Autoimmunity in Wiskott-Aldrich syndrome. Curr Opin Rheumatol 2003; 15: 446-453.
Shcherbina A, Rosen FS, Remold-O´Donnell E. WASP levels in platelets and lymphocytes of Wiskott-Aldrich syndrome protein correlate with cell dysfunction. J Immunol 1999; 163: 6314-6320.
Shin CR, Kim MO, Li D, Bleesing JJ, Harris R, Mehta P et al. Outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome. Bone Marrow Transplant. 2012; 47: 1428-1435.
Wiskott A. Familiärer, angeborener Morbus Werlhoffi? Monatsschrift für Kinderheilkunde 1937; 68: 212.
OMIM (Online Mendelian Inheritance in Man)
Search: Wiskott-Aldrich syndrome
GeneReviews (University of Washington)
www.genetests.org (select "GeneReviews", then "Titles")
search: WAS-related disorders
The Swedish Information Centre for Rare Diseases produced and edited this information material.
The medical expert who wrote the draft of this information material is Professor Anders Fasth, The Queen Silvia Children's Hospital, Gothenburg, Sweden.
The relevant organisations for the disabled/patient associations have been given the opportunity to comment on the content of the text.
An expert group on rare diseases, affiliated with the University of Gothenburg, approved the material prior to publication.
Publication date: 2013-03-12
Version: 4.0
Publication date of the Swedish version: 2012-11-29
For enquiries contact The Swedish Information Centre for Rare Diseases, The Sahlgrenska Academy at the University of Gothenburg, Box 422, SE-405 30 Gothenburg, Sweden. Tel: +46 31 786 55 90, email: email@example.com.
The Swedish Information Centre for Rare Diseases
Wiskott-Aldrich syndrome in Swedish
Rare diseases in Swedish
This knowledge database provides information on rare diseases and conditions. The information is not intended to be a substitute for professional medical care, nor is it intended to be used as a basis for diagnosis or treatment.


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Foundations of Wheel Throwing
Babson College's Sorenson Center for the Arts
Weekly Event - Every Tuesday: 7:30 PM to 7:00 PM
Wellesley, MA
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San Francisco, California
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Florence, Italy
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Description: This 8-week introductory course exposes students to key ceramic and wheel throwing principles, vocabulary and techniques. Central to the course is a "learn by doing" approach and sensitivity toward creativity and fun. Students are responsible for throwing and designing an actual cup (or shot glass), bowl, plate and vase if you've got mad skills. Students are introduced to the central concepts of wedging, centering, throwing, trimming and glazing. In addition, they learn how wheel throwing is used as a meditative art to manage and control stress levels. Class meets once a week for eight weeks with a two hour class each weel and the studio fee gives students unlimited access to glaze and clay for the semester.
Note: When signing up for this event just sign-up for the first class of the semester and you will automatically be signed up for every subsequent class after that.
This course is taught by Babson sophomore Matt Hard
If you have any questions please e-mail Alex Spies
Sorenson Arts Center
25 Babson College Dr
Babson College's Sorenson Center for the Arts
The Richard W. Sorenson Center for the Arts (Sorenson Center) offers a diverse array of programming in theater, dance, music, film, video, literary art, and visual arts for on-campus audiences and the general public at the College's award-winning Carling-Sorenson Theater and Sorenson Family Visual Arts Center. It also supports the creative and performing experiences of student organizations while offering field-based learning opportunities for students working within business and liberal arts curricula.


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