text:
Summary: Histidine phosphatase superfamily (branch 2)
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Phosphatase Edit Wikipedia article
A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation). This action is directly opposite to that of phosphorylases and kinases, which attach phosphate groups to their substrates by using energetic molecules like ATP. A common phosphatase in many organisms is alkaline phosphatase. Another large group of proteins present in archaea, bacteria, and eukaryote exhibits deoxyribonucleotide and ribonucleotide phosphatase or pyrophosphatase activities that catalyse the decomposition of dNTP/NTP into dNDP/NDP and a free phosphate ion or dNMP/NMP and a free pyrophosphate ion.[1][2][3]
Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (PTM), with up to 30% of all proteins being phosphorylated at any given time. Protein kinases (PKs) are the effectors of phosphorylation and catalyse the transfer of a γ-phosphate from ATP to specific amino acids on proteins. Several hundred PKs exist in mammals and are classified into distinct super-families. Proteins are phosphorylated predominantly on Ser, Thr and Tyr residues, which account for 86, 12 and 2% respectively of the phosphoproteome, at least in mammals. In contrast, protein phosphatases (PPs) are the primary effectors of dephosphorylation and can be grouped into three main classes based on sequence, structure and catalytic function. The largest class of PPs is the phosphoprotein phosphatase (PPP) family comprising PP1, PP2A, PP2B, PP4, PP5, PP6 and PP7, and the protein phosphatase Mg2+- or Mn2+-dependent (PPM) family, composed primarily of PP2C. The protein Tyr phosphatase (PTP) super-family forms the second group, and the aspartate-based protein phosphatases the third.
Cysteine-dependent phosphatases (CDPs) catalyse the hydrolysis of a phosphoester bond via a phospho-cysteine intermediate.[4]
The free cysteine nucleophile forms a bond with the phosphorus atom of the phosphate moiety, and the P-O bond linking the phosphate group to the tyrosine is protonated, either by a suitably positioned acidic amino acid residue (Asp in the diagram below) or a water molecule. The phospho-cysteine intermediate is then hydrolysed by another water molecule, thus regenerating the active site for another dephosphorylation reaction.
Metallo-phosphatases (e.g. PP2C) co-ordinate 2 catalytically essential metal ions within their active site. There is currently some confusion of the identity of these metal ions, as successive attempts to identify them yield different answers. There is currently evidence that these metals could be Magnesium, Manganese, Iron, Zinc, or any combination thereof. It is thought that a hydroxyl ion bridging the two metal ions takes part in nucleophilic attack on the phosphorus ion.
Phosphatases can be subdivided based upon their substrate specificity.
|Tyrosine-specific phosphatases
|Serine-/threonine-specific phosphatases
|Dual specificity phosphatases
|Histidine phosphatase
|Lipid phosphatase
Serine/threonine PP (PPM/PPP) families
Protein Ser/Thr phosphatases were originally classified using biochemical assays as either, type 1 (PP1) or type 2 (PP2), and were further subdivided based on metal-ion requirement (PP2A, no metal ion; PP2B, Ca2+ stimulated; PP2C, Mg2+ dependent) (Moorhead et al., 2007). The protein Ser/Thr phosphatases PP1, PP2A and PP2B of the PPP family, together with PP2C of the PPM family, account for the majority of Ser/Thr PP activity in vivo (Barford et al., 1998). In the brain, they are present in different subcellular compartments in neuronal and glial cells, and contribute to different neuronal functions.
The PPM family, which includes PP2C and pyruvate dehydrogenase phosphatase, are enzymes with Mn2+/Mg2+ metal ions that are resistant to classic inhibitors and toxins of the PPP family. Unlike most PPPs, PP2C exists in only one subunit but, like PTPs, it displays a wide variety of structural domains that confer unique functions. In addition, PP2C does not seem to be evolutionarily related to the major family of Ser/Thr PPs and has no sequence homology to ancient PPP enzymes. The current assumption is that PPMs evolved separately from PPPs but converged during evolutionary development.
Class I: Cys-based PTPs
Class I PTPs constitute the largest family. They contain the well-known classical receptor (a) and non-receptor PTPs (b), which are strictly tyrosine-specific, and the DSPs (c) which target Ser/Thr as well as Tyr and are the most diverse in terms of substrate specificity.
Class II: Cys-based LMW-PTPs
This class of PTPs is represented by a single gene in humans encoding the 18 kDa low MW phosphatase (LM-PTP/LMW-PTP). Related classes are widely distributed in living organisms and were highly conserved through evolution. The preservation of this class of phosphatases and the involvement of LMPTPs in many common diseases suggest that it is involved in the regulation of many fundamental processes in cellular physiology.
Class III: Cys-based PTPs
The third class of PTPs contains three cell cycle regulators, CDC25A, CDC25B and CDC25C, which dephosphorylate CDKs at their N-terminal, a reaction required to drive progression of the cell cycle. They are themselves regulated by phosphorylation and are degraded in response to DNA damage to prevent chromosomal abnormalities.
Class IV: Asp-based DSPs
The haloacid dehalogenase (HAD) superfamily is a further PP group that uses Asp as a nucleophile and was recently shown to have dual-specificity. These PPs can target both Ser and Tyr, but are thought to have greater specificity towards Tyr. A subfamily of HADs, the Eyes Absent Family (Eya), are also transcription factors and can therefore regulate their own phosphorylation and that of transcriptional cofactor/s, and contribute to the control of gene transcription. The combination of these two functions in Eya reveals a greater complexity of transcriptional gene control than previously thought . A further member of this class is the RNA polymerase II C-terminal domain phosphatase. While this family remains poorly understood, it is known to play important roles in development and nuclear morphology.
Physiological relevance
Phosphatases act in opposition to kinases/phosphorylases, which add phosphate groups to proteins. The addition of a phosphate group may activate or de-activate an enzyme (e.g., kinase signalling pathways[10]) or enable a protein-protein interaction to occur (e.g., SH2 domains [11]); therefore phosphatases are integral to many signal transduction pathways. It should be noted that phosphate addition and removal do not necessarily correspond to enzyme activation or inhibition, and that several enzymes have separate phosphorylation sites for activating or inhibiting functional regulation. CDK, for example, can be either activated or deactivated depending on the specific amino acid residue being phosphorylated. Phosphates are important in signal transduction because they regulate the proteins to which they are attached. To reverse the regulatory effect, the phosphate is removed. This occurs on its own by hydrolysis, or is mediated by protein phosphatases.
Protein phosphorylation plays a crucial role in biological functions and controls nearly every cellular process, including metabolism, gene transcription and translation, cell-cycle progression, cytoskeletal rearrangement, protein-protein interactions, protein stability, cell movement, and apoptosis. These processes depend on the highly regulated and opposing actions of PKs and PPs, through changes in the phosphorylation of key proteins. Histone phosphorylation, along with methylation, ubiquitination, sumoylation and acetylation, also regulates access to DNA through chromatin reorganisation.
One of the major switches for neuronal activity is the activation of PKs and PPs by elevated intracellular calcium. The degree of activation of the various isoforms of PKs and PPs is controlled by their individual sensitivities to calcium. Furthermore, a wide range of specific inhibitors and targeting partners such as scaffolding, anchoring, and adaptor proteins also contribute to the control of PKs and PPs and recruit them into signalling complexes in neuronal cells. Such signalling complexes typically act to bring PKs and PPs in close proximity with target substrates and signalling molecules as well as enhance their selectivity by restricting accessibility to these substrate proteins. Phosphorylation events, therefore, are controlled not only by the balanced activity of PKs and PPs but also by their restricted localisation. Regulatory subunits and domains serve to restrict specific proteins to particular subcellular compartments and to modulate protein specificity. These regulators are essential for maintaining the coordinated action of signalling cascades, which in neuronal cells include short-term (synaptic) and long-term (nuclear) signalling. These functions are, in part, controlled by allosteric modification by secondary messengers and reversible protein phosphorylation.
It is thought that around 30% of known PPs are present in all tissues, with the rest showing some level of tissue restriction. While protein phosphorylation is a cell-wide regulatory mechanism, recent quantitative proteomics studies have shown that phosphorylation preferentially targets nuclear proteins. Many PPs that regulate nuclear events, are often enriched or exclusively present in the nucleus. In neuronal cells, PPs are present in multiple cellular compartments and play a critical role at both pre- and post-synapses, in the cytoplasm and in the nucleus where they regulate gene expression.
Learning and memory
In the adult brain, PPs are essential for synaptic functions and are involved in the negative regulation of higher-order brain functions such as learning and memory. Dysregulation of their activity has been linked to several disorders including cognitive ageing and neurodegeneration, as well as cancer, diabetes and obesity.
See also
- ^ Davies O, Mendes P, Smallbone K, Malys N (2012). "Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism". BMB Reports 45 (4): 259–64. doi:10.5483/BMBRep.2012.45.4.259. PMID 22531138.
- ^ Martin, S. S. and Senior, H. E. (1980). "Membrane adenosine triphosphatase activities in rat pancreas". Biochim. Biophys. Acta 602: 401–418. doi:10.1016/0005-2736(80)90320-x. PMID 6252965.
- ^ Riley, M. V. and Peters, M. I. (1981). "The localization of the anion-sensitive ATPase activity in corneal endothelium". Biochim. Biophys. Acta 644: 251–256. doi:10.1016/0005-2736(81)90382-5. PMID 6114746.
- ^ Barford D (November 1996). "Molecular mechanisms of the protein serine/threonine phosphatases". Trends Biochem. Sci. 21 (11): 407–12. doi:10.1016/S0968-0004(96)10060-8. PMID 8987393.
- ^ Zhang ZY (2002). "Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development". Annu. Rev. Pharmacol. Toxicol. 42 (1): 209–34. doi:10.1146/annurev.pharmtox.42.083001.144616. PMID 11807171.
- ^ Mumby MC, Walter G (October 1993). "Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth". Physiol. Rev. 73 (4): 673–99. PMID 8415923.
- ^ Camps M, Nichols A, Arkinstall S (January 2000). "Dual specificity phosphatases: a gene family for control of MAP kinase function". FASEB J. 14 (1): 6–16. PMID 10627275.
- ^ Bäumer N, Mäurer A, Krieglstein J, Klumpp S (2007). "Expression of protein histidine phosphatase in Escherichia Coli, purification, and determination of enzyme activity". Methods Mol. Biol. 365: 247–60. doi:10.1385/1-59745-267-X:247. PMID 17200567.
- ^ Maehama T, Okahara F, Kanaho Y (April 2004). "The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover". Biochem. Soc. Trans. 32 (Pt 2): 343–7. doi:10.1042/BST0320343. PMID 15046605.
- ^ Seger R, Krebs EG (June 1995). "The MAPK signaling cascade". FASEB J. 9 (9): 726–35. PMID 7601337.
- ^ Ladbury JE (January 2007). "Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction". Acta Crystallogr. D Biol. Crystallogr. 63 (Pt 1): 26–31. doi:10.1107/S0907444906046373. PMC 2483503. PMID 17164523.
External links
- Phosphatases at the US National Library of Medicine Medical Subject Headings (MeSH)
This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
Histidine phosphatase superfamily (branch 2) Provide feedback
The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins. The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.
Literature references
Kostrewa D, Wyss M, D'Arcy A, van Loon AP; , J Mol Biol 1999;288:965-974.: Crystal structure of Aspergillus niger pH 2.5 acid phosphatase at 2.4 A resolution. PUBMED:10329192 EPMC:10329192
Rigden DJ;, Biochem J. 2008;409:333-348.: The histidine phosphatase superfamily: structure and function. PUBMED:18092946 EPMC:18092946
Internal database links
|His_Phos_1 PTH2
|Similarity to PfamA using HHSearch:
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000560
The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The relationship between the two branches is not evident by (PSI-)BLAST but is clear from more sensitive sequence searches and structural comparisons [PUBMED:18092946].
The smaller branch 2 contains predominantly eukaryotic proteins. The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.
Acid phosphatases (EC) are a heterogeneous group of proteins that hydrolyse phosphate esters, optimally at low pH. It has been shown [PUBMED:1989985] that a number of acid phosphatases, from both prokaryotes and eukaryotes, share two regions of sequence similarity, each centred around a conserved histidine residue. These two histidines seem to be involved in the enzymes' catalytic mechanism [PUBMED:8334986, PUBMED:1429631]. The first histidine is located in the N-terminal section and forms a phosphohistidine intermediate while the second is located in the C-terminal section and possibly acts as proton donor. Enzymes belonging to this family are called 'histidine acid phosphatases' and include:
- Escherichia coli pH 2.5 acid phosphatase (gene appA).
- E. coli glucose-1-phosphatase (EC) (gene agp).
- Yeast constitutive and repressible acid phosphatases (genes PHO3 and PHO5).
- Schizosaccharomyces pombe acid phosphatase (gene pho1).
- Aspergillus awamori phytases A and B (EC) (gene phyA and phyB).
- Mammalian lysosomal and prostatic acid phosphatase.
- Several Caenorhabditis elegans hypothetical proteins.
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function
|acid phosphatase activity (GO:0003993)
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
The graphic that is shown by default represents the longest sequence with a given architecture. Each row contains the following information:
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Pfam Clan
This family is a member of clan His_phosphatase (CL0071), which has the following description:
The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches [1].
The clan contains the following 2 members:His_Phos_1 His_Phos_2
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...
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- alignment generated by searching the metagenomics sequence database using the family HMM
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
|Representative proteomes
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
|Representative proteomes
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
External links
MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
|Seed source:
|Previous IDs:
|acid_phosphat; Acid_phosphat_A;
|Finn RD, Griffiths-Jones SR, Rigden DJ
|Number in seed:
|Number in full:
|Average length of the domain:
|323.30 aa
|Average identity of full alignment:
|15 %
|Average coverage of the sequence by the domain:
|63.62 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Model details:
|Model length:
|Family (HMM) version:
|download the raw HMM for this family
Species distribution
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
This chart is a modified "sunburst" visualisation of the species tree for this family. It shows each node in the tree as a separate arc, arranged radially with the superkingdoms at the centre and the species arrayed around the outermost ring.
How the sunburst is generated
The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. For each node in the resulting tree, we draw an arc in the sunburst. The radius of the arc, its distance from the root node at the centre of the sunburst, shows the taxonomic level ("superkingdom", "kingdom", etc). The length of the arc represents either the number of sequences represented at a given level, or the number of species that are found beneath the node in the tree. The weighting scheme can be changed using the sunburst controls.
In order to reduce the complexity of the representation, we reduce the number of taxonomic levels that we show. We consider only the following eight major taxonomic levels:
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Segments of the tree are coloured approximately according to their superkingdom. For example, archeal branches are coloured with shades of orange, eukaryotes in shades of purple, etc. The colour assignments are shown under the sunburst controls. Where space allows, the name of the taxonomic level will be written on the arc itself.
As you move your mouse across the sunburst, the current node will be highlighted. In the top section of the controls panel we show a summary of the lineage of the currently highlighed node. If you pause over an arc, a tooltip will be shown, giving the name of the taxonomic level in the title and a summary of the number of sequences and species below that node in the tree.
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Some species in the taxonomic tree may not have one or more of the main eight levels that we display. For example, Bos taurus is not assigned an order in the NCBI taxonomic tree. In such cases we mark the omitted level with, for example, "No order", in both the tooltip and the lineage summary.
Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown. Rather than leave out these species, we map them instead to their parent species. So, for example, for sequences belonging to one of the Vibrio cholerae sub-species in the NCBI taxonomy, we show them instead as belonging to the species Vibrio cholerae.
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The tree shows the occurrence of this domain across different species. More...
Species trees
We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics.
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Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers.
Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt, allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the His_Phos_2 domain has been found. There are 64 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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The annual WLN Football Banquet will be held on Monday November 10 at Baypointe Country Club (Richardson Rd at Haggerty). Doors open at 6:00; Dinner at 6:30. All 2014 Knights players and family are invited to this evening celebration of the 2014 season. RSVP's are due by November 1st. Please download this flyer for all the details!
The Knights travelled to Pinckney for a KLAA cross-over game, and made the trip worth while by holding the lead throughout the game and pulling away late for a 42-27 victory. The win keeps Northern's play-off hopes alive heading into homecoming week. Congrats to the team on the big win.
The Knights got back to their winning ways in a convincing 56-7 victory at Lakeland. With the win, the trophy not only made the bus ride to Lakeland, but more importantly it got to take the ride home to WLN. Next up is a trip to Pinckney for the KLAA crossover game.
Join us for the annual pink-out game as the Knights take on the Warriors from Western. There also will be a halftime ceremony in honor/memory of loved ones afflicted with cancer. Please support the various fundraising, which will support the American Cancer Society.
The Knights had an amazing comeback scoring 2 touchdowns in the last 2 minutes of the game, but lost in the final minute 50-43. The Knights will regroup and get ready for our pink-out game with Western at home on Thursday.
The Knights held off a persistent Livonia Stevenson team earning a 33-27 victory. The Knights moved to 2-0 on the season. Next up is KLAA North Division play, with the Knights hosting Walled Lake Central.
The Knights kicked off the 2014 season on the road with a hard fought 34-12 victory. Northern briefly trailed in the 3rd quarter, but imposed their will by scoring the final 27 points of the game to claim the victory. See the mlive article or the Oakland press article for more coverage. Next up is the home opener next Friday vs. Livonia Stevenson.
Car decals are now available for order. See the order form or Sharon Burton for more details. Order deadline is September 15.
WLN Football Picture Day & Picnic were a success. Many of the photos from the event, including team photos, and individual varsity player photos are now available on our Photo site. Click the "Photos" button at top of home page.
Great news!!! We now have available online apparel shopping for football. You can customize your favorite gear with selected logos and have it shipped directly to your door. There are hundreds of products to choose from... and we earn money on every single purchase. Simply click the banner advertisement on our homepage, or from bottom right hand corner of any page on our site. Also, use promo code JUL141 (all caps!) for $10 off your purchase. Happy shopping!!! Please note, however, that this site will not offer our unique logos. Apparel with our unique logos will continue to be sold during all home games.
The Varsity Knights entire schedule is here and includes 4 home games, all of which are also special events:
See the Sign-up Genius button on the right side of the home page to go to the Sign-up Genius page for WLN Football.
Congratulations to the 2013 Football team on earning Division 1 Academic All State honors. Thier hard work paid off this past season on the field and more importantly in the classroom!
Reminder that the Kroger Rewards expire every year on May 1st, so please rember to re-register your Kroger rewards card for the 2014 season. Kroger's will give back a portion of your bill to the boosters club when you register your card. This is a simple way to support our football program! Once registered, you will begin to see Walled Lake Nothern Football Boosters appear at the bottom of every Kroger receipt. See instructions below.
How do I sign up for Kroger Rewards
|Friday, August 29
|Bloomfield Hills
|Saturday, September 6
|Livonia Stevenson
|Friday, September 12
|WL Central
|Friday, September 19
|Waterford Mott
|Friday, September 26
|Waterford Kettering
|Thursday, October 2
|WL Western
|Friday, October 10
|Friday, October 17
|Friday, October 24
|Traverse City West
Advertising Sponsorships are needed!!!

subset: commoncrawl


text:
Ladies' Home Journal Honors Downy Touch of Comfort With the Magazine's Quarterly 'Do Good Award'
CINCINNATI, Oct. 21 /PRNewswire/ — Procter and Gamble's (NYSE: PG) Downy fabric softener brand is proud to announce it has received the Ladies' Home Journal "Do Good Award" for its continuous efforts in bringing comfort to hospitalized children through the Downy Touch of Comfort program. This exciting honor will help propel the brand toward its inspiring goal of delivering 10,000 quilts to children staying in Children's Miracle Network hospitals across the country. Quilts were made possible through the partnership with the charity Quilts For Kids, Inc.
"Ladies' Home Journal empowers and inspires its readers to give back within their communities," said Mary Pochobradsky, Downy Marketing Director. "The Downy brand also feels passion for giving back within our communities, and bringing comfort to those who need it most. That is why we created the Downy Touch of Comfort program, giving comfort to hospitalized children through hand-made quilts."
The Downy Touch of Comfort program was nominated in 2010 to be a recipient of the Ladies' Home Journal "Do Good Award" amongst twenty three recipients. Each quarter, Ladies' Home Journal recognizes businesses that set an admirable example by actively contributing to making the world a better place. The corporations that receive this stamp are socially responsible, committed to doing good, and an inspiration to all. As a brand that has strived to comforted families for 50 years, Downy met these criteria by bringing new levels of comfort to those who need it most – hospitalized children.
"I'm so happy to be able to champion this program," adds Vice President and Publisher Julie Pinkwater. "It feels so right because it's in our DNA. We're the magazine that brought Never Underestimate the Power of a Woman to market in 1941. We still run the column and use that as our tagline today. I'm sure we're going to unearth tons of stories and programs that will encourage even more people to get involved."
Each year in the United States, children account for more than 6 millions hospital stays and must confront the challenges of overcoming illness and being away from the comforts of home. Security items such as quilts can help these children feel more comforted during medical treatments and hospital stays. That's why in 2009, P&G's Downy fabric softener, in partnership with Quilts for Kids, Inc., launched the Downy Touch of Comfort program to bring comfort and security to hospitalized children. This program delivers personalized, handmade quilts to children in Children's Miracle Network hospitals nationwide, helping to give them comfort when they need it most. Chandra Wilson, a mother of three and star of "Grey's Anatomy," has joined in Downy's efforts to try and comfort as many children as possible by spreading awareness and personally delivering quilts to children.
People across the United States can add a "touch of comfort" in their communities in numerous ways by visiting Downy.com to help make a difference in a child's life. At the site, people can make donations to benefit the program, contribute a quilt to be delivered to a child in need or learn how to get involved in their local Quilts for Kids chapters. For more information on Downy Touch of Comfort, please visit www.Downy.com/HelpingKids.
About Ladies' Home Journal
Ladies' Home Journal was founded in December 1883. Ladies' Home Journal magazine has been inspiring, informing and entertaining women for 125 years. Published monthly by Meredith Corporation (NYSE: MDP), Ladies' Home Journal has a circulation of 3.8 million and a readership of 12.1 million. The magazine's interactive online companion, www.lhj.com, has 1.8 million unique visitors and 20 million page views each month.
About Downy®
Downy® offers a line of advanced fabric care conditioning products that helps keep clothes feeling soft and smelling fresh. Downy's family of liquid fabric softener includes: Ultra Downy, Ultra Downy® Free and Sensitive, Downy with Febreze® Fresh Scent, Downy Pure Essentials(TM), Downy Experientials(TM), and Downy Simple Pleasures®. Downy also offers a variety of dryer sheets. For more information, please visit www.Downy.com.
About Procter & Gamble (NYSE:PG)
Four billion times a day, P&G brands touch the lives of people around the world. The company has one of the strongest portfolios of trusted, quality, leadership brands, including Pampers®, Tide®, Ariel®, Always®, Whisper®, Pantene®, Mach3®, Bounty®, Dawn®, Gain®, Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. The P&G community includes approximately 135,000 employees working in about 80 countries worldwide. Please visit www.pg.com for the latest news and in-depth information about P&G and its brands.
SOURCE Downy


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Learn how to create interactive PDF forms with Adobe InDesign.
Learn how to create great print PDFs with Adobe InDesign.
Using Microsoft Word and Adobe InDesign, it's now much easier to create valid, accessible PDF files. Learn how.
Make interactive PDFs with forms, buttons, and multimedia in Adobe InDesign.
Learn to take a magazine originally designed as a static Adobe InDesign document and convert it to an interactive PDF.
Use InDesign to design a wide range of digital documents, from interactive PDFs to apps for the iPad and more.
A practical, nuts-and-bolts look at working with PDFs in a production environment.
Shows how to use InDesign to add animation and interactivity to digital documents.
Shows print designers how to use InDesign, in conjunction with Acrobat and Flash Professional, to lay out and design a wide range of digital documents.
InDesign CS4: 10 Things to Know About Interactive PDFs Explores the great features within interactive PDF files and the techniques used to add movies and sounds to PDFs.
"I had to quickly learn InDesign for a project at work. I was overwhelmed and sure I'd never be able to master it in time. I found lynda.com and started the tutorials. They were comprehensive, detailed, organized—I finished my project and it looks sensational." —Angele I.
more from our members »


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Still trying to locate details about Gloria Lockett? If your answer is yes, then you are in the right place. PeopleFinders.com can help you locate information on Gloria Lockett like email, known aliases, and physical address. And with our access to public records information and exclusive DataTsunami™ logic, it won't take you long to zero in on what you are looking for.
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text: Susan Kemmerer is the author of the highly acclaimed book, Homeschool Supermom…NOT!. She and her husband Dale have, by God's grace, been homeschooling their nine children for almost twenty five years – with 5 graduated and 4 to go (or 9 more years of homeschooling ahead!). Susan has authored a number of textbooks, including "Apples Daily Spelling Drills for Secondary Students" and "Research in Increments." She has had articles published in several homeschool periodicals, and has spoken at support groups (including CHEA Leadership, ENOCH Leadership, Covenant Fellowship of PA, and Sovereign Grace of NJ) and at conferences across the country (including CHAP, MidSouth, LEAH, SouthEast, NOVA, CHEA, Midwest Homeschoolers, and ENOCH). In her spare time, Susan enjoys reading, writing, and needlework. Besides being with their children and grandchildren, the Kemmerer's love spending time in fellowship with the believers in their local church, Grace Community Church of Souderton (a Sovereign Grace church) where they had the privilege of serving as care group leaders. Dale and Susan (along with their children) run their Schoolhouse Publishing, from their home in Franconia, PA


text:
Your gateway to Seminary news, information, and educational opportunities, and access to your virtual meeting place for Bethany alumni/ae!
Continuing Education
- Access the ATLAS Database [1]
- Peruse Bethany's Special Historical Library Collections [2] online
- See the list of Webcasts [3]
- View upcoming graduate-level courses [4]
- View upcoming Academy-level courses
- Apply for a graduate-level class as an occasional student [5]
- Request a transcript - Download and print the request form [6], then mail to address at top of form
Support Your Alma Mater
- Investigate ways to give [7] a current gift
- Review information for planned giving [8] options
- Give a gift through our secure online donation [9] page
- Consider volunteer service as a Brethren House [10] host
- Shop for Bethany merchandise [11]
Current Life at Bethany
- Read the latest news [12]
- View upcoming events [13]
- Read our latest publications [14]
- Read and subscribe to Brethren Life & Thought [15]
- Take a sabbatical [16]at Bethany as a Pastor in Residence
Did You Know . . . ?
- Bethany's Alumni/ae Association includes persons who are no longer enrolled as students and who have completed at least a year's worth of credits in a Bethany Seminary degree or training program. (This includes graduate, undergraduate, and non-degree program alumni/ae from Bethany Bible School, Bethany Biblical Seminary, Bethany Training School, the School of Sacred Music, Bethany Theological Seminary, and Brethren Academy for Ministerial Leadership Programs.)
- Alumni/ae may enroll in Bethany's graduate or academy classes for continuing education. The Brethren Academy for Ministerial Leadership administrates continuing education and awards Continuing Education Units (CEUs). Alums who have earned a graduate-level degree may take graduate courses for credit by registering as occasional students. Application and enrollment fees are waived for alumni/ae.
- Alums have the opportunity each year to elect persons to Bethany's Alumni/ae Coordinating Council. Three persons serve staggered three-year terms. They plan alumni/ae events and serve as an advisory board to the Institutional Advancement Staff.
The Bethany Alumni/ae Coordinating Council
Current members of the council are: Greg Davidson Laszakovits (1999), Elizabethtown, Pennsylvania, term ends in 2012; Kerby Lauderdale (1968), Portland, Oregon, term ends in 2014; Dana McNeil (2004), Dunlap, Illinois, term ends in 2013; Rhonda Pittman Gingrich (1998), Minneapolis, Minnesota; Alumni/ae Representative to the Board of Trustees and ex-officio member of the Council, term ends in 2014.
For more information, please contact:
Jenny Williams, Director of Communications and Alumni/ae Relations
firstname.lastname@example.com [17] 765-983-1825
Lowell Flory, Executive Director of Institutional Advancement and Gift Planning
email@example.com [18] 765-983-1805 or 800-287-8822 x1805


text:
Tablet. Hotels for Global Nomads
Travel Better.
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San Francisco, California
37.769663 -122.449830
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First reviewed by Tablet
For hip T-shirts, sneakers, and jeans, Villains has you set. Denim favorites like 7 for All Mankind and Citizens of Humanity are found here, and the helpful salespeople are always on hand to give recommendations for a perfect fit.
0 people found these commends helpful.


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AMBITIOUS GAL will clean your home/commercial space. $25/HR "Your priority list, not ours" Bonded/Refs. 720.351.6004.
Copyright © 2015
Columbine Courier is your source for local news, sports, events, and information in South Jefferson County, Colo., and the surrounding area.


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- Magazine
- Conferences
- Leadership
- Playbooks
- Tactical Briefs
- Collaborative Manufacturing
- Control Panel Optimization
- Embedded systems & Trends
- Embedded Vision in Manufacturing
- Energy Efficiency
- Ethernet I/O Networking
- Factory Floor Network Deployment
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- Hands-on Guide to OEE
- HMI, From the Web to the Cloud
- Industrial PCs and the IoT
- Internet of Things
- Machine Safety
- Machine Safety Standards & Strategies
- Make a lasting connection
- Mechatronics @ Work: Insight & Technology Solutions
- Networking
- Opening Up Your Gateway to Asia
- Real-time Operational Intelligence (RtOI)
- Robotics in U.S. Manufacturing
- Robots & Machines in Motion
- The Future of Industrial PCs
- The power of PackML
- Webinars
- Channels
Download this free 97-page Batch Process Playbook loaded with industry expert advice on topics ranging from control systems, instrumentation, and industrial networks to energy management, security, and system upgrades.
| January 24, 2013
Alpha Wire Helps Embry-Riddle University Shoot for the Moon
Students in the Robotics Association at Embry-Riddle Aeronautical University have been hard at work designing their Lunabot to compete in the 2013 NASA Lunabotics Mining Competition. Alpha Wire was able to support the RAER team with EcoWire for their application.
The Robotics Association, a student organization at the Daytona Beach campus of Embry-Riddle Aeronautical University (ERAU, is the parent organization of many student teams that compete in seven different international competitions. There are five competitions sponsored by the Association for Unmanned Vehicle Systems International (AUVSI), the NASA Lunabotics Competition, and the Australian DSTO sponsored Multi Autonomous Ground-robotic International Competition. All require students to carefully document their work and present their designs to expert judges from industry and government.
RAER students are expected to compete in the 2013 NASA Fourth Annual Lunabotics Mining Competition on May 20-24th, 2013. This university-level competition is designed to engage and retain students in science, technology, engineering and mathematics (STEM). The challenge is for students to design and build an excavator, called a Lunabot, that can mine and deposit a minimum of 10 kilograms of lunar simulant within 10 minutes. The complexities of the challenge include the abrasive characteristics of the BP-1, the weight and size limitations of the Lunabot, and the ability to telerobotically or autonomously control the Lunabot from a remote mission control center.
This year the scoring for the mining category will not be based primarily on the amount of material excavated in the allowed time, but instead will require teams to consider a number of design and operation factors such as dust tolerance and projection, communications, vehicle mass, energy/power required, and full autonomy.
EcoWire was used in various wiring solutions, ranging from sensor data transmission to high voltage power systems. EcoWire as a lightweight and thin wiring solution appropriate for working with compact vehicles where size and weight are often major constraints. EcoWire also achieves increased performance in a wire that is fully recyclable by using a unique insulation, a modified polyphenylene ether (mPPE) thermoplastic. mPPE-based insulation is non-halogenated and contains no heavy metal pigments, allowing it to help manufacturers meet Waste Electrical and Electronic Equipment (WEEE) requirements.
COMPANIES IN THIS ARTICLE: Alpha Wire
E-Book Special Report
IT Delivers on Automation's Promise
Sign up to receive timely updates from the editors at Automation World and download this FREE Special Report on the transformative power of data in manufacturing. By integrating information and automation technologies, manufacturers are finally achieving major gains in productivity from their automated systems.


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Escondido may crack down on yard parking
ESCONDIDO - Concerns that an overnight parking ordinance the city has been discussing for several months could pull many cars off the street and into front yards, the City Council will consider a new ordinance Wednesday that would crack down on yard parking.
Jon Brindle, the city's planning chief, said Monday that city officials don't want residents to start using their front lawns as parking lots when they are no longer allowed to park an unlimited number of cars on the street.
"The desire to get parked cars off the street is not accompanied by a desire to see them in front yards," said Brindle.
The proposed law would strengthen the city's existing prohibition against yard parking by allowing citations to be issued without a 24-hour warning and by including the Police Department in enforcement efforts.
Currently, all warnings and citations are handled by city code compliance officers, who say they are handcuffed by a cumbersome citation process that allows most repeat offenders to escape punishment.
Including police would also close a nighttime enforcement gap, because police officers work around-the-clock and code compliance officers do not.
"The proposed ordinance enables immediate enforcement whenever an officer observes a violation, and will significantly improve our ability to vigorously address recurring public nuisances," according to a city staff report.
Critics of the proposed overnight parking ordinance have described it as an intentional attack on the city's poor Latino families, but a majority of the City Council has said that law will help attract higher-paying jobs to Escondido by making the city a safer and more attractive place to live and work.
Bill Flores, a spokesman for El Grupo, an umbrella group of civil rights organizations, declined to comment Monday on the yard-parking ordinance. But he said that El Grupo plans to address "all of the council majority's attacks" on Latinos in the next few weeks.
Councilman Dick Daniels said Monday that the yard-parking ordinance is not directly tied to the overnight parking restrictions, but he said it is important to make the city look better.
"We need to set the standard that it's not acceptable to park in your yard," said Daniels. "It impacts property values in some neighborhoods and can change the perception of the quality of those areas."
Leslie Milks, the city's code compliance manager, said the biggest problem with the current yard-parking rules is the 24-hour warning. She said violators simply move their cars after the warning to appease the code compliance officer, but then resume yard parking shortly afterward.
"It has become a little bit of a cat-and-mouse game," Milks said.
The new approach would replace cumbersome administrative citations with much simpler parking citations, said Deputy City Attorney Gary McCarthy. Code compliance officers must deliver an administrative citation directly to the violator, somewhat like a subpoena, while a parking citation can be left on a windshield, he said.
The new approach would also allow the third violation within a 12-month period to be charged as a misdemeanor. The current rules already allow the city to charge yard parking as a misdemeanor, but the new approach makes it much simpler, said McCarthy.


text:
MP3 Music Download
1.000.000 - 5.000.000 downloads
- Some people will find it useful
- Depends on what you look for
- Thousands of similar apps
"All You Need Is Music"
Comentado por Anna Grace / Jul 08, 2014
An app to find all the music you need
MP3 Music Download is an extremely simple application that is created for searching for your favorite music and having access to a quick download.
LOVER COCO is the developer of MP3 Music Download, which has a poor design and it's not exactly original.
You can
Search by artist or song name
Find music, mp3, sound, track file
Listen with idrisyou player ,
Filter by artist or song name on the music library
Set as ringtone, notification or alarm
Add to playlist your favorite songs
Algumas listas em que este aplicativo aparece: Reviewed by Anna Grace.
E não mais..... não gostei
Melhor que o 4shared, mas falta mais opções para musica brasileira (atual)...
Muito bom!
E muito bom eu adorei
Muito bom
Mto bom baixem esse é da hora


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What is the most recent MBP that supports OS X.6.8?
Started May 4, 2013 | Questions thread
What is the most recent MBP that supports OS X.6.8?
May 4, 2013
And can X.6.8 support the Retina display?
I currently have a mid-2010 MBP with the high rez alternative screen and that works fine.
Cheers, geoff
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Porphyria Center - Richland, WA
WebMD Physician Directory
Richland, Washington
Porphyria facts*
*Porphyria facts medically edited by William C. Shiel Jr., MD, FACP, FACR
Other Related Porphyria Articles
Emergency Contact for Richland
Nearby Richland Hospitals *
Kadlec Regional Medical Center
Lourdes Counseling Center
Kennewick General Hospital
Lourdes Medical Center
PMH Medical Center
Good Shepherd Medical Center
*Provider Directory Terms of Use:
The WebMD 'Provider Directory' is provided by WebMD for use by the general public as a quick reference of information about Providers. The Provider Directory is not intended as a tool for verifying the credentials, qualifications, or abilities of any Provider contained therein. Inclusion in the Provider Directory does not imply recommendation or endorsement nor does omission in the Provider Directory imply WebMD disapproval.


text:
To embed, copy and paste the code into your website or blog:
5 Things Successful People Do Differently
Have you ever thought about why you've been able to achieve some goals and not others?
It's not just because you're predisposed to certain talents.
It's also about what you DO to try to achieve those goals.
To put all of this into perspective, here are five things that successful, goal-achieving people do differently.
Please see full article below for more information.
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10|18|2007 07:42 pm EDT
Group of Internet Mavericks Lasso Domain Cowboys.com
A group of internet domain name investors led by Eric Rice apparently has banded together to make the winning bid to acquire the domain name Cowboys.com . The domain name was placed back up for auction in the Moniker.com silent auction after the representatives from the Dallas Cowboys football team reportedly backed out of their winning bid of $275,000 from the live domain auction held the week before.
The auction which ended today had a total of 6 bids and an ending price of $370,000, a final sale price well above the final bid price from the live auction.
Update:Â When Rice was asked in an email about the purchase he said his team has "been studying the thriving country and western market for over 6 months and are glad to finally have the domain needed to proceed in the category".


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Allow other users to connect with you by administrating this profile.
Improve your business presence on the Internet.
The administrator profiles have priority over other search results.
Administering this profile may update, supplement or delete it.
You are in: Services - Professional, scientific and technical activities - Activities of head offices; management consultancy activities - Management consultancy activities - Management consultancy activities
Other categories that might interest you ...
Type of profile: Individual
ISIC main activity: 7020 - Management consultancy activities
Main Federal Administration of Public Revenue (AFIP) Activity: 741401 - Directing and Company Management Consulting Services done by members of Corporation Administrators and/or Supervisors
DUNS Number: 975825790
Trade Profile: Service Providers
- Segui Juan Francisco 4602, 6, 25, Capital Federal (1425), Capital Federal, Argentina - To see mapSegui Juan Francisco 4602 Capital Federal Capital Federal Argentina
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Wilmington Trust Boosts Private Client Team In Connecticut
May 29, 2015
Wilmington Trust has appointed John Barrett to serve high net worth individuals and families from
Wilmington Trust has appointed John Barrett to serve high net worth individuals and families from
The largest hedge funds dominate the total sector in terms of assets, highlighting how concentrated
The blue-blooded US bank is to cut thousands of jobs to cut costs and as it spins off businesses, a
Which is the world's most competitive economy? The answer is.....the US. Asian economies,
The global rating agency has, as part of a review, adjusted ratings on a raft of the world's major
V-Rooms have created Family Office Vaults to help wealthy families protect sensitive data.
US Trust has today unveiled the findings of its 2015 Insights on Wealth and Worth report, which
Citi Private Bank has created a new role in the US capital, recruiting from JP Morgan to head up
This month, family office consultant Joe Reilly interviews Lisa Gray of graymatter Strategies on
Foundation Source has released its fourth annual report on the private foundation sector, revealing


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Paris, France
My Rating
Excellent driver. Very well done !
Paris, France
My Rating
Lights out in the theatre for most of the tour. We are big fans of "Phantom of the Opera" show so we enjoyed it despite the inconvenience.
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13 CFR 126.306 - How will SBA process the certification?
(a) The D/HUB or designee is authorized to approve or decline certifications. SBA will receive and review all certifications, but SBA will not process incomplete packages. SBA will make its determination within 30 calendar days after receipt of a complete package whenever practicable. The decision of the D/HUB or designee is the final agency decision.
(b) SBA may request additional information or clarification of information contained in an application submission at any time.
(c) If SBA approves the application, SBA will send a written notice to the concern and automatically enter it on the List described in § 126.307.
[63 FR 31908, June 11, 1998, as amended at 69 FR 29423, May 24, 2004; 70 FR 58974, Oct. 11, 2005]
Title 13 published on 2014-01-01
no entries appear in the Federal Register after this date.
Title 13 published on 2014-01-01
The following are ALL rules, proposed rules, and notices (chronologically) published in the Federal Register relating to 13 CFR 126 after this date.


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University of Minnesota Chapter
Active and general fraternity news. This is the default, and will always display on the home page.← Older posts
The Minnesota Alumni Society would like to invite our alumni to the Chapter House to celebrate the founding of the Minnesota Chapter. On February 22, 1892 the Minnesota Chapter was founded by a small group of men along with the guidance and support of Br. William Watts Folwell (Geneva 1857), the first president of the University of Minnesota. Each year since then, we gather to celebrate the achievements of the past year, meet new friends, and relive old memories. Please join us this year as we celebrate our 123rd Anniversary on Friday, February 20, 2015 at the Minneapolis Club. Schedule of Events: (Coat & Tie Required) 5:00pm Social & Fellowship – Minneapolis Club 7:00pm Dinner – Minneapolis Club 9:30pm Social & Fellowship – Chapter House Please reach out to your pledge brothers, former housemates, and/or anyone you have remained close to over the years and invite them to this event. The cost of the event is $60. The annual alumni dues of $50 will be due during registration as well. Please RSVP to this event no later than Friday, February 13, 2015 to Steve Ehrfurth '06 by calling (612) 281-5218 or via email at firstname.lastname@example.com in Front Page News | Comments Off
Members of Alpha Delta Phi at the University of Minnesota lit up social media with a pledge to help end sexual violence. Today's media is inundated with stories of victims who have endured sexual assault, and the Alpha Delts have responded with a public commitment to help lead efforts toward increased vigilance and sensitivity to crimes of a sexual nature, from harassment to assault. The active members took part in a Greek-wide photo project through the Minnesota Alpha Beta chapter of the Sigma Lambda Beta fraternity which brought the university's sororities and fraternities together and encouraged smiles and documented promises to stand up against domestic/gender/sexual violence. The safety of all those who find a home at the University of Minnesota in one way or another, be it student or faculty, has and will always be a top priority for our organization and we encourage others to become active in helping to spread awareness of the issue and do what they can to prevent these incidents through education and proactive choices. The U of M offers resources through The Aurora Center on both Minneapolis and St. Paul campuses. The website reminds people that "The Aurora Center provides a safe and confidential space for students, faculty, staff, alumni, and family members or friends affiliated with the University of Minnesota, TC or Augsburg College who are victims/survivors/concerned people of sexual assault, relationship violence, or stalking." Here, students can learn the steps of the Sexual Assault Response Protocol and how to report incidents of violence and harassment. A 24-hour helpline is also available for round-the-clock assistance as well. Please take some time to visit their site to learn more about this resource so that you can help spread information to those who may need it. The Aurora Center: Advocacy & Education http://www1.umn.edu/aurora/ For more photos from the Minnesota Betas [read more…]Posted in Front Page News | Comments Off
Big shout out to Br. John Komarek '07 who has found success this summer after opening his brand new business, Curly: Creative Communications. After graduation from the College of Liberal Arts, John found work in the communications field in a variety of arenas, from the political to the public sector to the non-profit. His extensive experience had given him a ready arsenal of insight into the internal and external communication needs of businesses. John created Alpha Delta Phi's Professional Networking Nights, in which brothers were invited to attend a presentation by a fellow alum — topics related to professional experiences. These events were highly praised by attendees and Komarek's efforts proved worthwhile. This year, he founded Curly: Creative Communications with the help of his associate Mina Saremi. John and Mina have been busy meeting and greeting local business owners in the community and establishing a solid client base. While Mina takes care of the sales, John spearheads the creative duties and brings fresh options to people's advertising, marketing and public relations needs. For people looking to get in front of a camera with a simple message to viewers, John had the idea to provide a simple, in-office setup and let people simply stand in front of a high-definition camera with professional lighting and, well, TALK. And thus, Curly's "Talking Head" program was born. Simple, yet needed. A fine example of Br. Komarek's problem solving abilities as a communications professional. We wish John the best of luck in his new endeavor and his brothers at Alpha Delta Phi are proud of him and his newfound success as a new business owner. (pictured above, Br. Jake Jacobson, left, poses with Br. John Komarek at Curly's official ribbon cutting.) Nik VanDenMeerendonk '05 Secretary Alpha Delta Phi MN Alumni BoardPosted in Front Page News | Comments Off
Being Greek is more than yogurt, The Odyssey and John Stamos. Depending on who you talk to, opinions on college Greek life will vary to dramatic degrees — from those in unabated, enthusiastic favor of it to those who can't help but feel disdain and abhorrence. In a 2012 USA Today article penned by Nicole Glass, Greek life is analyzed for its social, moral and academic benefits. There is no hiding the fact that some organizations become part of less than honorable situations and these occurrences are certainly not to be taken lightly. But the dark side of Greek life has always been favored by the media for obvious reasons and it has done few favors to the honorable aspects of fraternities and sororities. The school year has just begun, and students and parents alike will find themselves considering what it is to be a part of Greek life. This is an article worth reading, should you find yourself curious and undereducated about this misunderstood community. EXAMINING THE BENEFITS OF GREEK LIFE By Nicole Glass May 8, 2012 USA Today Since 1825, all but three U.S. presidents have been members of a fraternity. 85% of Fortune 500 executives were part of Greek life. The first female astronaut was Greek. So was the first female senator. And college graduation rates are 20% higher among Greeks than non-Greeks. Which begs an obvious question: Does being in a fraternity or sorority increase your chance for success? Nine million college students are members of a Greek organization and whether they join to make friends, to build their resumes, to go to parties or to learn leadership skills, they each have an incentive to change some aspect of their life. A common deterrent for joining are the sometimes-negative stereotypes associated with Greek life. Fraternities and sororities are often associated with [read more…]Posted in Front Page News | Comments Off
As the weather gets colder and we leave behind the days of ice bucket challenges and Top 40 summer hits, it doesn't mean the Alpha Delts didn't have a little fun during the dog days. The 8th Annual Xaipe Classic Golf Outing on Saturday, August 16 at Goodrich Golf Course in Maplewood, MN was another successful outing. Actives and alumni alike got together to enjoy a day on the links in friendly competition. Tooling around in golf carts, lining up their shots with terrible-to-precise accuracy and most certainly teasing each other for time spent in sand traps and water hazards, the boys in green made the most of their annual golf game. Thanks again to all those who participated in the event and we hope to see you again next year! Nik VanDenMeerendonk '05 Secretary Alpha Delta Phi MN Alumni BoardPosted in Front Page News | Comments Off
Once again, the 8th Annual Xaipe Classic Golf Outing will be held on Saturday, August 16 at Goodrich Golf Course in Maplewood, MN. Many brothers do not see each other during the summer months, and the golf classic is a good way to reconnect before the annual Homecoming celebration. We encourage all alumni to participate (regardless of your skill level) and join us for a day of relaxation, excitement and of course, golf! After the outing, there will be an awards ceremony for the winning team followed by a grill-out at the Alpha Delta Phi chapter house on the University of Minnesota campus. Nik VanDenMeerendonk, MN '05 Secretary Alpha Delta Phi MN Alumni BoardPosted in Front Page News | Comments Off
We are happy to announce the return of the Alpha Delta Phi Professional Networking Night! These events, started a few years ago, were designed to bring our brothers together in a setting to learn about each others' professional experiences and share their own. The lecture format saw alumni stepping up to give presentations on their careers while fielding questions from those in attendance. These events have been very beneficial to younger members as they make their way through the beginning stages of their own careers and seek professional advice from trusted mentors. The events are slated to start in late summer of this year. #adpmnpnn Nik VanDenMeerendonk, MN '05 Secretary Alpha Delta Phi MN Alumni BoardPosted in Front Page News | Comments Off
Last weekend, The Alpha Delta Phi Fraternity was to hold its winter national board meeting in Cambridge. MA. We reserved a block of rooms at The Kendall Hotel. On New Year's Eve, owing to the impending snow storm, we decided to postpone the meeting. Notwithstanding the group cancellation policy, the hotel's General Manager, Brenda Anderson, graciously agreed to provide the Fraternity with a credit for a future stay, for which we are very grateful. The aftermath of the storm was predicted to be brutal; the temperature in the Boston area would plummet to sub-zero ranges. We contacted The Kendall Hotel with a novel idea: instead of applying the credit to a future stay by Alpha Delta Phi, could we make the rooms available to clientele of Rosie's Place or other homeless shelters which would no doubt be stretched beyond their resources this weekend? Anderson said that in her 10 years of working at the hotel she had never had such a request. Despite some understandable initial reluctance, we were able to work with the hotel so the two organizations could do something positive for those less fortunate. That bitterly cold weekend The Kendall housed several individuals in need of shelter and will donate the balance of Alpha Delta Phi's credit to Rosie's Place in the form of blankets, bedding and other essentials. On behalf of Alpha Delta Phi, I wish to thank The Kendall Hotel for stepping up and commend them for being such outstanding corporate citizens.Posted in Front Page News | Comments Off
What do Jennifer Aniston, Christie Brinkley, Brad Pitt and the MN Alpha Delta Phi kitchen all have in common? And don't say "immaculate hair growth." No. Seriously, don't. Instead, can you say FACELIFT? That's right. After years upon years of dutiful service to our house, the old kitchen has earned its right to once again be young and beautiful. It's like a fairy tale where an old crone wants nothing more than to be a spry, vivacious lass in the prime of her life. And then one day, POOF! She's a knockout. And she's the most popular gal at the ball. But her true beauty lies on the inside because of her long wonderful history and the memories she has and whatnot. Okay, I may have gotten a little off track there — look, the point is, the kitchen is sporting a new, updated look after extensive renovation over the summer. With many thanks to the efforts of the alumni organization and their generous donations, we have been able to provide an upgrade that our house so deeply deserves. New cabinets, countertops, sinks, stove, oven, etc. The works. And why not? This kitchen has served generations of our members and provided countless memories along the way. We can barely express how thrilled we are to offer active members a chance to create meals with the new amenities. Many were able to see the improvements at Homecoming and many more will see them at our upcoming Founder's Day event. We hope that this new kitchen will help to create memories that will endure the test of time — like Joan Rivers' face. Nik VanDenMeerendonk, MN '05 Secretary Alpha Delta Phi MN Alumni BoardPosted in Front Page News | Comments Off
I know. It's been awhile since our last update. Sorry about that. But we're here now. Gazing into each others' eyes and pondering…what we're going to eat for dinner or something. Anyway… As we await the completion of the chapter house's brand new kitchen (yes, our kitchen is being completely renovated and upgraded), I'd like to take a moment and thank our brothers who have contributed content to our chapter's award-winning website. It's not always on everyone's minds to sit and write a piece centered around a fraternity theme, especially in their free time. But in the past year or two, we have had some remarkable stories written by some of our alumni that help to keep others informed of the chapter's activities as well as what is happening in the personal and professional lives of our alumni. Some have written introspective pieces that reflect on what is to be a part of this organization – the trials and rewards – and some have offered sage advice to the classes that come after us. Brothers write pieces touting the achievements of their fellow members and memorializing those we have lost. From time to time, a humorous anecdote makes its way into the jabber jungle and exists only to make us laugh. As a literary organization, it's a goal of ours to maintain and cultivate the ability to express ourselves via the written word. We do value eloquence and a firm grasp of proper grammatical concepts, but it's understood that what's more important lies beyond the technique; it's the message being put forth. The words shared by our brothers deserve recognition as much as the events they describe. While they may not reach a wide number of eyes, I hope that those that do find them see what we're trying to [read more…]Posted in Front Page News | Comments Off ← Older posts
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May is Pregnancy Awareness Month® (PAM)
LOS ANGELES, April 29, 2011 /PRNewswire/ — Pregnancy Awareness Month® (PAM), is proud to announce PAM's annual "Motherhood Begins Now" event, to launch a month-long national campaign of education and social connection for women across the country. O.N.E.(TM) Coconut Water, a leading producer of all-natural healthy Coconut Water-based beverages, is the official title sponsor.
This fourth annual, free family event will take place on Sunday, May 1, 2011 at the Writer's Boot Camp building located in the Bergamot Station Arts Center in Santa Monica from 12pm – 4pm. Presented by O.N.E. Coconut Water, the PAM launch event will be hosted by celebrities Ali Larter, Amy Smart, Anna Getty and Brenda Strong. The event will offer an unprecedented opportunity to celebrate pregnancy and motherhood with families and friends, while learning about PAM's four key initiatives – Nurture, Educate, Exercise and Nutrition.
Pregnancy Awareness Month® Co-founders, Anna Getty and Alisa Donner are passionate about putting pregnancy intelligence at the forefront for women everywhere, which was the catalyst to establish an awareness campaign. As Getty explains, "For thousands of years women have thrived within their community. I hope that PAM will continue to uplift women in the spirit of creation and motherhood in our new age of community."
"We're honored to be the signature sponsor of this important campaign and to support PAM's efforts to educate pregnant women and families everywhere," said O.N.E. Founder and CEO Rodrigo Veloso. "We appreciate the opportunity to highlight the powerful hydrating benefits of O.N.E. Coconut Water, which are essential to pregnant women and nursing moms."
Other highlights of the launch event include the opportunity to meet Jessica Denay, author/founder Hot Mom's Club with her second book launch and signing The Hot Mom's Handbook – Laugh and Feel Great from Play Date to Date Night; Mommy Spa services provided by GreenBliss EcoSpa and Freshology with manicures, pedicures, facials and massages; children's activities produced by Ladybug Jane and over 25 product booths with samples, information and giveaways; a maternity fashion show presented by A Pea in the Pod, hosted by Amy Tara Koch, style expert and author of the best-selling book Bump It Up; and expert round-table panels on various pregnancy topics with Dr. Alan Greene MD and Brenda Strong, among others.
Pregnancy Awareness Month® events are happening across the US throughout the month of May. Look for events in your area at www.pregnancyawareness.com.
About PAM
Celebrated every May, Pregnancy Awareness Month® was established in 2008 by author and lifestyle expert Anna Getty and producer and mompreneur Alisa Donner. Their mission is to empower, inspire and build a community of support for expectant women and families. PAM has quickly blossomed into a variety of grassroots events across the country during the month of May. The PAM website is available 24/7 providing tips, new products and social connection for all. www.pregnancyawareness.com
About O.N.E. Coconut Water
O.N.E. Coconut Water is the premier, all-natural beverage company established in 2005 by Rodrigo Veloso. Their award winning and #1 selling coconut water is fast-becoming recognized as America's healthiest beverage – providing enhanced hydration (with all five essential electrolytes) and essential nutrition.
O.N.E. Coconut Water is packaged in environmentally friendly Tetra Pak cartons, underscoring the company's commitment to the Earth and O.N.E is a founding member of the Conscious Capitalism Alliance (consciouscapitalism.org) and uses its business platform to promote healthy lifestyle choices and otherwise serve society.
In addition to sponsoring Pregnancy Awareness Month, O.N.E. supports several nonprofit organizations – most importantly Healthy Child Healthy World (www.healthychild.org) – and is committed to offering beverages that satisfy the Alliance for a Healthier Generation School Beverage Guidelines. The Alliance for a Healthier Generation, founded by the American Heart Association and William J. Clinton Foundation, works to address one of the nation's leading public health threats – childhood obesity.
O.N.E. Coconut Water is available in over 18,000 retail outlets including Whole Foods Market, Publix, Kroger Stores, Safeway, 7 Eleven, Cost Plus World Markets, Vitamin Shoppe and on Amazon.com.
SOURCE O.N.E. Coconut Water


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Danica Patrick not satisfied with Daytona finish
Updated: February 24, 2013, 5:43 PM ETAssociated Press
Danica Patrick turned in the best finish by a woman in the Daytona 500.
Still, she's beating herself up a little bit after fading on the final lap.
With one lap to go, Patrick was running third behind Jimmie Johnson and Dale Earnhardt Jr. The crowd was going nuts, hoping the pole-sitter could somehow pull out an improbable win.
All of a sudden, Patrick's inexperience in stock cars showed as her No. 10 car slipped back to eighth. Johnson held off Earnhardt to win the Great American ...
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Seething with resentment over what they felt was the Core Committee's one-sided decision to create separate Telangana, Ministers from Seemandhra on Friday warned the party leadership that they would take tough decision if their plea against division of the State was ignored.
They dashed off a letter party chief Sonia Gandhi conveying their strong feelings after a meeting of a large contingent of State Ministers, Union Ministers and MPs at Andhra Pradesh Bhavan. Several leaders wanted Union Ministers to take the mantle of convincing the high command against bifurcation of the State and criticised them for not doing enough for protecting the interests of Seemandhra people. The 90-minute long meeting entrusted to Union Ministers K. S. Rao, K. Chiranjeevi and M. M. Pallam Raju the responsibility of handing over the letter to Ms. Gandhi. In their letter, the leaders recalled how Andhra Pradesh was created in 1956 when Jawaharlal Nehru was the Prime Minister and how Indira Gandhi had strongly opposed bifurcation in 1969. Even Rajiv Gandhi was always against division, they pointed out, and urged Ms. Sonia Gandhi not to take the blame for bifurcation of Andhra Pradesh. They pointed out that if Telangana was created without consulting them, they would be forced to take certain hard decisions. "The impression we get after coming here is that the high command has taken a decision in favour of Telangana. We want to put as much pressure as we can to see that the high command reconsiders its move," a senior Minister told The Hindu from New Delhi.
"It's all speculation"
Talking to reporters, Minister for School Education S. Sailajanath expressed the hope that the Centre would not take a decision without considering the party's fate in Seemandhra. Minister for Municipal Administration Maheedhar Reddy said that the Ministers were still hopeful that that State would remain united.
Dr. Sailajanath claimed that the talk of division was mere speculation. "If the high command indeed decides in favour of a separate State, we will hold a broadbased meeting of MLAs and MLCs to decide the future course of action," he said.
Keywords: Seemandhra Ministers, Core Committee, Telangana, Sailajanath, Seemandhra, AP politics


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Combo Breaker Live!
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Mortal Kombat X moves forward with a snappier version of the previous game's fighting and some cool new characters, but the story and other features around the edges feel a bit rough in spots.
The ways that Axiom Verge resembles Metroid help set up and drive home the ways that Axiom Verge is most definitely not Metroid.
Hotline Miami's thrillingly brutal gameplay is stretched to the point of breaking in this aesthetically pleasing, but otherwise disappointing sequel.
Company »
Teenage Mutant Ninja Turtles: Training Lair is a free Xbox 360 Kinect game based on the 2014 film. The game is sponsored by Pizza Hut and features their advertising. Players will have the opportunity to use all four of the Ninja Turtles weapons and swipe at on-screen items for maximum ninja training.
The titular Ty returns in an all-new side-scrolling adventure for Windows 8.
First person boomerang flingin'.
The Toy Soldiers franchise goes mobile in this Window Phone 7 release.
Blade Kitten is a side-scrolling, action platformer by Krome Studios. It follows the story of Kit Ballard, bounty hunter and one of the last few remaining survivors of a race of cat/human hybrids called the Felion. The game is based on a webcomic by studio co-founder Steveth
Owl-based action adventure game for Xbox 360, PlayStation 3, Wii and DS. It looks like a hoot! GET IT!?
A downloadable portal for official emulation of retro video games for the Xbox 360 and PC, featuring offerings from the Atari 2600 and Intellivision as well as early arcade games by Atari and Konami.
Star Wars: The Clone Wars -- Republic Heroes takes place during the first and second seasons of the TV cartoon Star Wars: The Clone Wars. It features the art style of the cartoon and was released on Xbox 360, Wii, PC, Nintendo DS and Playstation.
Krome Studios's PS2/Wii action game released to coincide with the film of the same name.
Based on the Star Wars: The Clone Wars film, players can take control of their favorite Jedi and battle it out on the Wii.
Scene It? Box Office Smash, a follow up to Scene It? Lights, Camera, Action, is a movie trivia game that allows up to four players to play, either locally or online.
While not a tie-in to Hellboy II: The Golden Army, players can control Hellboy, Abe Sapien, and Liz Sherman. The game came with a free movie ticket for the film, and featured the voices of Ron Perlman, Doug Jones and Selma Blair.
The Legend of Spyro: The Eternal Night is the second part of the Legend of Spyro trilogy. Cynder has been rescued from the power of the Dark Master. The Ape King, Gaul, has now risen to power and is intent on resurrecting the Dark Master.
A multiplayer mini-game collection starring characters from the Viva Piñata TV Show.
A New Beginning is the first of the Legend of Spyro trilogy. The dragons are at war with the Malefor. The fate of the dragons lies in the hopes of the prophecy of the purple dragon. Spyro must fight the forces of Malefor and a black dragon named Cynder.
Ty the Tasmanian Tiger 3 revolves around saving the outback from the Quinkan invaders. The third game in the Ty the Tasmanian Tiger series was also the first to be published by a company other than EA Games.
King Arthur is a hack and slash game based on the 2005 movie of the same name
Ty the Tasmanian Tiger 2: Bush Rescue expands on the game play of the first game, but features new elements, such as driving sequences, mech battles, and an expanded world. In Ty 2, Ty must fight Boss Cass once again to save the Australian outback.
as Atari Melbourne House
Platform game based on the Jet Fusion episodes of the Jimmy Neutron animated TV show.
Ty the Tasmanian Tiger is a 3D platformer made by Krome Studios. In it, Ty travels around the Australian outback in search of five mystical talismans that will not only save his family from the Dreamworld, but his entire species from the wrath of Boss Cass.
2000 WCT champion Sunny Garcia lends his name to Sunny Garcia Surfing by Ubi Soft.
Disney's extremely Goofy Skateboarding is a skateboarding game the includes Goofy and Max from the television show Goof Troop
as Infogrames Melbourne House
Superbike racing
as Melbourne House
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Ants under the magnifier fry quick
from Das Racist (Ft. El-P) – Shut Up, Man Lyrics on Genius
He's comparing rappers to ants because when you begin to analyze them, you realize how whack they are. You look at something under a magnifying glass and it fries up. This links to the last line about flies.
El works as a standard bearer then for hip-hop analysis. You'll get burnt as soon as he looks at you.
To help improve the quality of the lyrics, visit Das Racist (Ft. El-P) – Shut Up, Man Lyrics and leave a suggestion at the bottom of the page


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Amount to be spent on new buildings, creation of new posts
Chief Minister Jayalalithaa on Friday announced allocation of Rs.10 crore for upgrading the Tamil Nadu Government Dental College and Hospital here into a centre of excellence in dentistry.
Making a suo motu statement in the Assembly, she said that the amount would be spent on constructing new buildings and creation of new posts.
Ms. Jayalalithaa said that her government had decided to upgrade it into a centre of excellence, taking into consideration the welfare of patients from Tamil Nadu as well neighbouring States, who throng hospital.
She said over 2,000 patients were being treated in the hospital daily and her previous regime had allotted land and Rs.14 crore for expanding the college and hospital. The amount was used for constructing a multi-storeyed building and it was inaugurated by her on March 3, this year.
Reiterating that her government was committed to the motto of "health is wealth," and keen on improving the health and sanitation of people across the State, Ms. Jayalalithaa said Primary Health Centres (PHCs) had been upgraded to provide treatment to rural masses on a par with their urban counterparts.
"The PHCs have been provided with equipment to handle deliveries and surgeries. Moreover, new buildings are being constructed for the hospitals and existing buildings are refurbished."
Ms. Jayalalithaa said dental wings had been set up in all medical college, district 150 taluk and 15 non-taluk hospitals. "To create awareness about dental health among rural people, dental treatment is provided in 22 non-taluk hospitals and 208 PHC three days a week," she said.
Keywords: Dental college upgradation, Jayalalithaa