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Richard Fuld, the former chief executive officer of defunct Lehman Brothers Holdings Inc., said the Wall Street firm reported certain repo transactions as sales because accounting rules required it to do so.
General Motors Co.'s internal investigation into why it took more than a decade to recall vehicles linked to fatal flaws will lead to employees being dismissed and clear Chief Executive Officer Mary Barra of wrongdoing, according to people familiar with the effort.
Mike Robinson, General Motors Co. vice president of sustainability and global regulatory affairs, is the highest-ranking executive dismissed by the automaker as it investigates defective parts linked to 13 deaths, said a person familiar with the matter.
The North Carolina Utilities Commission hired Jenner & Block Chairman Anton Valukas to aid in its probe of whether it was misled when it approved Duke Energy Corp.'s takeover of Progress Energy Inc., the law firm said.
General Motors Co. has placed two engineers, Ray DeGiorgio and Gary Altman, on paid leave for their roles in events leading to the recall of 2.59 million small cars with potentially defective ignition switches tied to at least 13 deaths, said two people familiar with the matter.

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Jewish Museum
Circumcision Battle Coming to Scandinavia
A growing attachment to the male umlaut
In the Jewish Museum's Closet: Photos of Gay Men at Berlin's Holocaust Memorial
The museum removed photos of gay men at Berlin's Holocaust memorial from an exhibit on sex and identity
Wiley's People
The young artist-provocateur Kehinde Wiley's dignified portraits of men in Israel are the focus of a major new show at the Jewish Museum
Event Horizon
Agenda: A month of Jewish film in New York, Shalom Auslander reads in Boston, Donna Karan shops, Susan Sontag is revived, and more
Working Glass
A Jewish Museum exhibit on the New York Photo League shows how its photographers fetishized poverty for the sake of propaganda
Seeing Double
A Jewish literature is easy to identify. But defining Jewish art is a task of Talmudic complexity, as a new book, Jewish Art, makes clear.
Film Theory
Agenda: Tovah Feldshuh gets old, New York City dines out for farmers, the Klezmatics play Prague, and more
Daybreak: U.N. Bloc Moves Against Syria
Plus, further Gaza warring, bulking Southern defenses, and more in the news
Maira Kalman in Residence
Artist literally sweeps the streets at her Jewish Museum exhibit


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Special Correspondent
HYDERABAD: Industry has expressed its disappointment that no concrete steps have been announced on how the government is planning to reduce fiscal deficit, though no special sops are expected from the vote-on-account budget.
Talking to presspersons here on Monday, B. V. R. Mohan Reddy southern region chairman of Confederation of Indian Industry said no impetus was given to the industry. "I am disappointed. I expected some thing more from the budget, though it is just a vote-on-account."
It was more of a progress report of the UPA government, said M.R. Vikram, partner of M. Anandam & Co, chartered accountants.
Shakti Sagar, MD of ADP, said that the IT industry expected extension of 10A and 10B sunset clauses of the Software Technology Parks of India at least by two more years.


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Full 360 degree flight Option
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Lt. Commander
Join Date: Dec 2007
Posts: 120
# 22
Also if you have seen the new Star Trek...there is a scene where the Enterprise is face-to-face with Nero's ship and they aren't on a level plane or altitude. When the cam pulls back the Enterprise is upside down compared to Nero's ship. I know that it was not seen often in the TV Series or movies, but the FACT is that there are no restrictions in REAL SPACE. You can go and any direction and Cyrptic should honor that and add it to the game. Hell...make two different servers. One for Easy, one for Hardcore. If the full 360 never happens then it really sucks that Cryptic isn't up to the challenge. Figures...


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Summer 2010 MSConnection Lone Star
Summer 2010 edition of MSConnection, the official magazine of the National MS Society: Lone Star
Moving Toward a world Free oF MS Summer 2010 The Official Magazine of the National Multiple Sclerosis Society: Lone Star This summEr, You Can SIZZlES KeeP YoUr EvEn WhEn TExas Mother Nature Smiles Meet our Cool on Cyclists Saddling Up For Spring Bike MS 2010 Volunteer Hall of Fame inductees Travel Sites Travel This Summer without Breaking the Bank if You or Someone You Know Has MS Studies show that early and ongoing treatment with an Fda-approved therapy can reduce future disease activity and improve quality of life for many people with multiple sclerosis. Talk to your health care professional or contact the national MS Society at nationalMSsociety.org or 1-800-344-4867 to learn about ways to help manage multiple sclerosis and about current research that may one day reveal a cure. The official magazine of the National Multiple Sclerosis Society: Lone Star Austin � Corpus Christi � Dallas � Fort Worth Houston � San Antonio The Official Magazine of the National Multiple Sclerosis Society: Lone Star 1-800-344-4867 Board of Trustees Chairman Brad roBBINS Secretary Mark MClElaNd Treasurer GErald MErFISH Regional Executive Vice President Mark NEaGlI MSConnection Editor JaMES BlaCk � 2010 National Multiple Sclerosis Society: Lone Star The National Multiple Sclerosis Society does not endorse products, services or manufacturers. Such names appear here solely because they are considered valuable information. The National Multiple Sclerosis Society assumes no liability for the use of contents of any product or service mentioned. Information provided by the Society is based upon professional advice, published experience and expert opinion. Information provided in response to questions does not constitute therapeutic recommendations or prescriptions. The National Multiple Sclerosis Society recommends that all questions and information be discussed with a personal physician. We mobilize people and resources to drive research for a cure and to address the challenges of everyone affected by MS. MS SToPS PeoPle FroM Moving we eXiST To MaKe SUre iT doeSn'T. Join THe MoveMenT Summer 2010 Volume 4 � Issue 2 CoNTENTS TABLE OF The Official Magazine of the National Multiple Sclerosis Society: Lone Star The Official Magazine of the National Multiple Sclerosis Society: Lone Star 18 Texas Sizzles Even When This Summer, You Can Keep Your Cool Letter from the Editor . . . . . . . . . . . . . . . . . . . .4 Mystery Symptoms Finally Explained by MS Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . .9 2010 Hall of Fame Inductees . . . . . . . . . . . . 14 Travel Sites Help You See the Sights This Summer . . . . . . . . . . . . . . . . . 21 Study Suggests Smoking and Exposure to Epstein-Barr Virus May Interact as MS Risk Factors . . . . . . . . . . . . . . . . . . . . . . 26 Genetic Study of Twins Employs New Methods for Examining Causes of Ms . . . . 28 Study Results Show Daclizuma Reduced Disease Activity in Relapsing MS and Reveal Novel Immune Mechanism . . . . . . . . 30 Drinking Milk during Pregnancy May Lower Baby's Risk of MS . . . . . . . . . . . 32 Migraine More Common in Women With MS . . . . . . . . . . . . . . . . . . . . . . 33 Evidence Supports Autoimmune Nature of Neuromyelitis Optica, an MS Mimic . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Closing Thoughts: Keep Moving to Support MS Research . . . . . . . . . . . . . . . . 42 10 Advocacy Efforts Provide Uplifting Feeling of Control 23 Mother Nature Smiles On Cyclists Saddling Up for Spring Bike MS 36 aSk THE PHarMaCIST FDA Approves New MS Drug Ampyra to Improve Walking MoVING Toward a world FrEE oF MS 3 FroM THe ediTor It's the Season to Take a New Look at Keeping You Connected Each new summer brings a fresh season to look at how we stay connected within our communities. With that in mind, it's time to add a refreshing new look to your MSConnection. Starting with this issue, our new format is just like you: brighter, bolder and a lot more colorful. WhenIfirstbeganwritingandeditingMSConnection several years ago, we took an informed look at really making thispublicationaliving,evolvingreflectionofourgreater MScommunity:Whatinformationwouldbebeneficialfor you? What stories could inspire you? What would get you moving? With your constructive feedback, we've worked to make MSConnection a publication that truly lives up to its name: a resource to help you stay connected with the MS community. We've focused on providing more news and fresh features you can genuinely use and share, such as updates on MS researchanddrugsindevelopment,profilesonMSactivism, event round-ups of happenings in your area, and personal stories from folks from all walks of life who face the daily challenges of multiple sclerosis. In this issue, for instance, you'll learn how to keep your cool during our sizzling summer; see how Port Neches resident James Paslean makes a difference in the lives of persons with disabilities; travel with MS activist Natalie Steadman as she navigates the halls of power in Washington, D.C. to raise MS awareness; read about an exciting new MS drug in I.D. Freed's insightful "Ask the Pharmacist" columnandfindoutwhycontributorJohnMcCoolwrites that "there's no longer any unknown to fear" after his MS diagnosis. 4 MSConnection � SuMMEr 2010 MSConnection online for the Vision Impaired It's all part of letting our unique stories live and thrive, and another crucial way of keeping ourselves connected. As the National MS Society continues moving forward to join forces regionally across Texas, Louisiana, Arkansas, New Mexico and Oklahoma, our resolve is more united and stronger than ever to do something to help everyone living with MS now. Whether you live in a big city, like Dallas or San Antonio, or you live in a rural community, like my hometown of Atlanta, Texas, MSConnection is your news resource for staying connected. I sincerely hope you enjoy this latest evolution in sharing our stories and keeping our MS community connected. Share your feedback, pass along your thoughts and spin me your story, because a good story � as everyone knows � is always in season. We've made your MSConnection even easier to view! If you'd like to read MS Connection in larger print, we've posted this edition � as well as an archive of past issues � online for you. Simply follow these steps: JointheMovementLoneStar.org and click the About Us link on the left-hand side of the page. page appears, click the MSConnection link to access this and prior editions. of the viewing page on your computer, you will find a box at the top of the page with "�" and "+" signs next to it. Click the "+" button to increase text size. STEP 1 Go to STEP 2 Once that James Black MSConnection Editor firstname.lastname@example.com National MS Society 8111 N. Stadium Drive, Ste. 100 Houston, TX 77054 STEP 3 To increase the size Connect with Self-Help Groups Near You How Many People Have MS? The National MS Society: Lone Star's Self-Help Groups provide opportunities for people living with multiple sclerosis, their families and friends to meet others affected by MS. Group meetings provide settings to share common experiences and concerns, network with others, give and receive emotional support, and obtain MSrelated information from peers and guest professional speakers. Self-Help Groups are facilitated by trained volunteers of the National MS Society: Lone Star. TofindaSelf-Help Group near you, visit JointheMovementLoneStar. org, click the Programs & Services link in the upper lefthand column, then click the link for Self-Help Groups. You can also call the Society at 1-800-344-4867 (press 2). Approximately 400,000 Americans have multiple sclerosis. Every week, about 200 people are newly diagnosed. Worldwide, MS affects about 2.5 million people. The Centers for Disease Control and Prevention (CDC) does not require U.S. physicians to report new cases and, because symptoms can be completely invisible, the numbers can only be estimated. Sign Up for Lone Star's Free Monthly MS E-Connection Subscribe to the free monthly MS E-Connection, providing monthly updates via e-mail on MS research, clinical trials, Lone Star programs, scheduled teleconferences and more. To sign up for free: 1. Visit JointheMovementLoneStar.org and click on the green box in the right-hand column that reads "Get Lone Star News Delivered to Your Inbox" 2. Enter your preferred e-mail address 3. Check the box that reads "MS E-Connection" 4. Click the gray "Submit" box 6 MSConnection � SuMMEr 2010 Making Milestones in MS: Read Our New Progress report "Moving Others toward a World Free of MS" is our brand-new report on our FY09 progress, highlighting personal stories, photos and milestones in research, advocacy, volunteering, fundraising, scholarships, wellness and much more. You can pick up a copy of the Milestone Report atourLoneStaroffices in Austin, Corpus Christi, Dallas, Fort Worth, Houston and San Antonio. You can also download it from the Lone Star website at JointheMovementLoneStar. org; click the left-hand navigation for About Us, followed by the link for Lone Star Resources. Find Clinical Trials in Your Area For information about clinical trials currently testing MS treatments, visit www.nationalMSsociety.org/ClinicalTrials. This page includes a link to trials currently seeking participants, as well as an explanation of trial phases, news of study results and more. If you do not have Internet access and need information on local clinical trials, contact the Society toll-free at 1-800-344-4867 (press 1 when asked). Make a Difference with Scholarship Fund Contributions You can make a powerful, positive difference by contributing to the National MS Society: Lone Star's Scholarship Fund. Your donation in any amount can provide a bright future for someone affected by MS who wants to attend college and, in turn, make a difference in the movement toward a cure for multiple sclerosis. We are actively seeking scholarship donors and sponsors. For information on how you can contribute to a needy student's future, contact Kristen Stubbs at email@example.com. MoVING Toward a world FrEE oF MS 7 This Summer, Make a Difference in Someone's Life: Volunteer The National MS Society has plenty of diverse, fulfillingvolunteeropportunities.Recent volunteer postings included photographers for Walk MS and Bike MS events, MS Ambassadors, activists, volunteer recruiters, secretaries, public relations specialists and warehouse workers, to name only a few. Volunteering is great for individuals and families, as well as groups from schools, churches and companies. We need and welcome you and the many talents and skills you offer in helping others living with multiple sclerosis. For information on volunteering, visit JointheMovementLoneStar.org and click the Volunteer link on the left-hand side of the page. You can also contact the National MS Society directly at 1-800-344-4867 (press 2). JointheMovementLoneStar.org Visit the address above and click the Volunteer link on the lefthand side of the page. WANT TO VOLUNTEER? Start a Movement in Your Community with Your Own Event Across our region, volunteers, communities and businesses are sharing their time and talents to raise money and awareness to benefiteveryonelivingwithmultiplesclerosis. Money raised from community � or thirdparty � events supports ongoing research initiatives into the cause, treatment and cure of MS, as well as important programs and services. Community events are volunteer-led and �supported. They can include anything from bowling tournaments and golf tourneys to bake sales and garage sales. You can learn more about staging these events in your community by downloading our 8 Community Events Guide. This handy guide includes everything you need, such as initial ideas to get you started and key guidelines you should follow. At the end of the guide is a Community Events Application to be completed and sent to your local National MS Society Community Development Representative before you hold your event. The Community Events Guide can found online. Visit JointheMovementLoneStar. org, click Fundraising Events in the left-hand navigation bar and then select Community Events. For additional information, you can alsocallyourlocalofficeoftheNationalMS Society toll-free at 1-800-344-4867 (press 2). MSConnection � SuMMEr 2010 Mystery Symptoms Finally Explained by MS Diagnosis by JOHN H. MCCOOL Relief. Strangely enough, that's what I felt when I was diagnosed with MS six months ago. r elief,becausethediagnosisfinallyput a name to a seemingly unconnected, at times debilitating and, indeed, scary set of symptoms that my doctors and I had been trying to make sense of for more than two years. It all started in March 2007 when, at just 30 years of age, I suffered a spontaneous carotid artery dissection, or tear, leading to a stroke � from which I recovered completely. MRIs revealed the stroke's effects on my brain but also unexplained lesions in other, unaffected parts. Where'd they come from? What's the link to my stroke? They have to be related, right? Yet while my notoriety grew among physicians and I was a frequent "science exhibit" at teaching hospitals in my native Kansas, I was no closer to an explanation. The mystery began to deepen in July 2008 when my feet began feeling like I was wearing metal insoles. Tingling then started moving up my legs. Within a month, though, Iwasfeelingfineagain.Ignorancebeing bliss, I airily dismissed it all as a case of bad footwear. My doctors remained skeptical, although still as perplexed as I. All was well until exactly one year later � July, again � when I was temporarily waylaid with bouts of dizziness and double vision. Doctors initially thought it was an inner ear infection, vestibular neuritis, and prescribed accordingly; but they demurred in doing much more since I was soon moving to Houston and getting married. (Onedoctordidaskmythen-fianc�e,very good-humoredly, whether she'd taken out a warranty on me.) Once in Houston, I was referred to Dr. Jerry Wolinsky. After running his own tests and analyzing my rather thick medical file,herevealedthatwhatI'dactuallybeen experiencingwasrelapsing-remittingflareups caused by multiple sclerosis. I had MS and I'd had it for at least two and a half years. As for the stroke, it was unrelated. Sometimes, he explained, it's like having "measles and a broken light bulb." At long last, it all made sense. Fortifiednowbyknowledge,atoughness I never knew I had, the support of loved ones and excellent treatment options, there's no longer any unknown to fear. I'm relieved that my disease has a name and I'm determined never to let it slow me down, not even in July. MoVING Toward a world FrEE oF MS 9 advoCaCY Advocacy Efforts Provide Uplifting Feeling of Control by NATALIE STEADMAN In March 2010, volunteers and National MS Society staff members traveled from Texas to Washington, D.C. to take part in the Society's Annual Public Policy Conference. Natalie Steadman, a member of the Society's Texas Government Relations Committee, shares her experience. y journey to Washington, D. C. began more than a year ago. I was sittinginmyoffice,readingthroughone of the National MS Society's publications, and noticed an ad for the 2009 Public Policy Conference in Austin. There was something about that ad, as if it was a calling that said, "This is it; this is where you need to get involved." Other than forwarding the occasional e-mail alert to legislators, I've never been an activist, but, the more I thought about 10 MSConnection � SuMMEr 2010 m it, I felt my professional experiences and background might give me the tools necessary to become one. I was diagnosedwithMSfiveyearsagoand afirmbelieverinthestatement,"Ifwe don't help ourselves, why should we expect others to?" ImadereservationstoflytoAustin and, from there, the National MS Society made it easy by providing an ideological format that educated us on how the system works. MoVING Toward a world FrEE oF MS 11 Formats for the state and national meetings were similar. After arriving in Washington, D. C. on March 1, I spent the next 72 hours on a pure adrenaline rush. I had been to the capital before, but never withsuchamission.Thefirstday-anda-half was spent in meetings where we were educated on the issues we would carry forward to our legislators the next day. The primary issues were: � BoldlyaskingCongresstosupporta $15 million appropriation to the Congressionally Directed Medical Research Programs (CDMRP) for MS research; � Boldlyaskingfortheinclusion of at least $95 million in the FY11 appropriations bill to fund lifespan respite programs and support family caregivers; � Establishingaregistrytomeasurethe incidence and prevalence of MS in the United States; and � EncouragingmemberstojointheMS Caucus. Iwassittinginmyoffice, reading through one of the National MS Society's publications, and noticed an ad for the 2009 Public Policy Conference in Austin. There was something about that ad, as if it was a calling that said, "This is it; this is where you need to get involved." 12 MSConnection � SuMMEr 2010 After sitting in meetings all day, I needed to get outside and move; I set out running toward DuPont Circle. As Igotthere,Inoticedaflagflyinghighin thedistance.Itwastheflagontopofthe White House. As close as it was, I knew I couldn't stop until I got there. It was a dark, misty night and, surprisingly, other than the Secret Service Agents, no one else was around. I stood looking at the White House, lit like a castle. It was then that I truly developed the inspiration and courage I needed for the mission the next day. I awoke the next morning with butterfliesinmystomach,butreadyto meet with numerous legislators from ourstate.Thebutterfliescamefrom knowing the importance of the mission, the stature of the people we were seeing and the realization that I was going to ask someone for $95 million for a program that could help people with MS. Our game plan was set and off we went to the Capitol. As we met individually with legislators or their staff members, we asked for their support on various issues. More importantly, we told our stories � the stories of living daily with the challenges of MS. We shared how granting support and funding for these issues gives us hope to continue living as if each day is going to be better because of the changes that could occur. As the day ended, although physically exhausted, I was emotionally exhilarated. Even though I'm 42 years old and have three college degrees, I don't think I really understood government until this trip. It truly is about the people. Whether it's through meetings, letters, e-mails or phone calls, our voices are heard. As a citizen, each of us has the right to voice needs and concerns. I hope you think of it as a duty, because it's actually a very simple process that anyone can do. I took away so many things from this trip. I met many wonderful people who I'm sure will become lifetime friends. I came away with a better understanding of the National MS Society staff and all of the things they can do for us; they are an invaluable resource for our cause. Lastly, I came away with a feeling of control. Having a disease that leaves us feeling mostly out of control, it was nice to feel like I was running the show for a day or two. Natalie is an Assistant Professor and Master of the Athletic Training Program at Texas Tech University Health Sciences Center. Her research interests are exercise physiology as it relates to endurance athletes, medical management of endurance events and exercise as it relates to multiple sclerosis. Port Neches Resident's Activism Lifts Public Access Barriers Port Neches, Texas resident James Paslean's efforts to improve the lives of people living with disabilities have resulted in exciting, visible changes to several city landmarks. With the help of Mayor Glen Johnson and City Manager Andre Wimer, Paslean's work has helped Port Neches become another shining example of people and resources coming together to keep those with challenges of mobility on the move. Most recently, Paslean contacted city officials about the U.S. Post Office on Port Neches Avenue. He knew that managing the post office doors was a difficult accomplishment for many people; the doors themselves are heavy and people sometimes have to wait for help from others to enter the building. That inspiration was the beginning of collaborative work with city officials to make several public buildings more accessible for all who live in Port Neches. Paslean's efforts led to changes for the Port Neches Post Office, the Effie and Wilton Hebert Public Library, and a nearby senior living facility. Paslean continues to be active as a volunteer in Port Neches, eagerly addressing unmet needs in the community and serving as a valuable resource for others who want to learn how to advocate for barrier-free living. MoVING Toward a world FrEE oF MS 13 volUnTeering At the National MS Society: Lone Star Conference and Annual Meeting in January, the following people were inducted into the Lone Star Volunteer Hall of Fame. Hall FaME INDUCTEES oF mEET our 2010 VOLUNTEER HEalTH CarE CHaMPIoN adVoCaCY CHaMPIoNS adVoCaCY CHaMPIoN DR. GEORGE HUTTON Dr. George Hutton is a champion for all with MS. As Director of the MS Clinic at Ben Taub General Hospital in Houston and Assistant Medical Director at the Maxine Messinger MS Clinic -- to name only two of his many roles -- Dr. Hutton has profound expertise in research, education and contribution to the care of persons with MS. He has served on countless Lone Star committees; presented to local, state and international medical society meetings, Self-Help Groups and research symposiums; provided Web-based educational programs for the medical professional and patient population; and saddled up in the BP MS 150 to become a top fundraiser. kIM & GarY CaMPBEll; lINda CokEr Sharing their voices on behalf of others are Linda Coker and Kim and Gary Campbell, who powerfully represent families living with MS. Since her diagnosis, Kim, her husband Gary and her sister Linda have all become MS activists as participants of the Austin Walk and members of its Steering Committee. They advocate tirelessly by sharing their personal stories with policymakers, giving testimony on legislative issues regarding family caregiver issues and visiting state legislators. dEE rYdEN Dee Ryden joined the movement before there was a movement. Diagnosed with MS in 1977, Dee founded and led the New Braunfels MSSupportGroupfiveyears later, providing support for the newly diagnosed and their families. Dee continued to share her voice and raise MS awareness, reaching out to local, state and national officials.In2009,Deetook the Society's health care issues to the halls of the Capitol in Austin and to Capitol Hill in Washington, D.C. MoVING Toward a world FrEE oF MS 15 SElF-HElP GrouP CHaMPIoN FuNdraISING EVENT CHaMPIoN MoVEMENT CHaMPIoN SHaroN BoSToN Sharon Boston has led her Self-Help Group in College Station for 25 years. She even wrote her master thesis on MS Self-Help Groups. Sharon keeps her Self-Help Group inviting, creative and informed by seeking out experts in her community to bring resources to her group members. She has established positive relationships with researchers at Texas A&M that help both the researchers and the group. They even get together each year for their renowned English Tea Social. ErIC PowEll Eric Powell is an employee of ExxonMobil and has been a Society volunteer for 13 years. Under Eric's leadership as Lone Star Safety Committee Chairman, the Society has consistently seen an expansion of cycling safety and rider education programs for all three Lone Star Bike MS events. Eric has also driven fundraising as a BP MS 150 participant; in the past 13 years, he has raised nearly $90,000. As captain of the 357-rider ExxonMobil team, his efforts have driven the team to raise $2.3 million in the last 13 years. STEVE HIGH Steve High is the chairman of the Executive Committee for San Antonio's Bike MS: Valero ride. He has been in this lead role for two years, transforming the committee from a staff-driven approach to a volunteer-guided one. Steve has made huge strides in recruiting others to ensure a variety of voices can be heard at every level. He is also atopfiveBikeMS fundraiser for six years in a row, raising more than $63,000 in the process. 16 MSConnection � SuMMEr 2010 CoMMuNITY EVENTS VoluNTEErS NaTIoNal VoluNTEEr Hall oF FaME FuNdraISING NaTIoNal VoluNTEEr Hall oF FaME ProGraMS NaTHaN dENToN & STEVE TrIES Nathan Denton and Steve Tries are the founders and organizers of the annual Movers and Shakers North Texas Golf Tournament. Since 2003, this tourney has raised almost $150,000 tobenefittheNational MS Society. Each year, the movers and shakers of the Dallas Metroplex � along withinfluentialcorporate partners�flocktothisevent that's become a fun, eagerlyanticipated one among Society fundraisers. Brad roBBINS As a Bike MS participant, Brad Robbins began riding on the Dow Team in Houston in 1998; since then, he has raised more than $410,000 through the BP MS 150. Brad has played an integral part in helping Dow achieve fundraising success and national team status, with Bike MS teams in Houston, Detroit and West Virginia. As a charter member of the Society's Corporate Star Program, Dow Chemical Company has raised more than $2 million in six years of participation nationally in Bike MS. Brad serves as a member of the Lone Star Board of Trustees and the National Board of Directors. Brad's leadership also provides valuable guidance for Lone Star operations and the Society's Regionalization Task Force. raNa ruSSEll Rana Russell wears many hats with the Society. Diagnosed with MS in 1995, Rana serves on the Lone Star Board of Trustees, Clinical Advisory Committee, Chapter Programs Committee, Quality of Life Task Force and Government Relations Committee. A family nurse practitioner, she works on the advocacy front through HAVA, the Accessible Voting Project and has advocated to lawmakers on disability issues. Rana is a top fundraiser, MS Ambassador, Self-Help Group Leader and instructor of an aquatics class for those living with MS. MoVING Toward a world FrEE oF MS 17 Cover STorY SIZ EvEn T C ZZlES a WhEn TExas This summEr, You Can Cool KeeP YoUr fter a cold and sometimes snow-covered winter across our area, things will really heat up this summer for regional residents. The scorching seasonal heat causes its own unique set of problems for everyone living with multiple sclerosis. Overheating can aggravate many MS symptoms, including increased fatigue, weakness and visual problems. This may happen when the mercury climbs on a hot summer day. It can also occur during exercise or exposure to any hot environment. Although summers throughout our region can be brutal, they don't have to be unbearable. There are ways to ensure you keep your cool this season: MoVING Toward a world FrEE oF MS 19 �Drinkplentyoffluids.Coolwateris thekeyfluidofchoice.Avoidcaffeine because it acts as a diuretic. �Usefans,airconditioningand even hand-held spray bottles. Air conditioners can be tax-deductible with a document from your doctor. start; continue adding cooler water during a period of 20 � 30 minutes. Submersion of the upper body in cool waterwillprovidetheoptimalbenefit. �Acoolbathorshowercanalsohelp reduce core body temperature following activity or exposure to a hot environment. �Exerciseinacoolenvironment.If you typically exercise outside, pick �Wearcommercialcoolinggarments cooler times of the day, usually early such as vests, headbands and morning; you could also consider neckbands; be aware, however, of bringing your outside routine in the added weight if you are using a by walking inside a local mall or cooling vest. A simple damp cloth or joining a gym. If you exercise inside, towel can be helpful if you don't have use air conditioning or fans to help one of these products. Wearing widemaintain your body temperature at an brimmed hats and light-colored, loose appropriate level. Exercising in cool clothing can also help. water � for example, a recommended temperature of 80 � 84 degrees � is an �Don'toverdoit,especiallywhenyou're excellent way to combat heat during outside in the heat. You know your physicalactivity;youcanfindavailable own limits. Don't push yourself to do aqua therapy classes near you at more than your body can handle. JointheMovementLoneStar.org under the Programs & Services link. �Asalways,consultyourdoctorbefore you start any exercise program or have �Trypre-coolingtodecreasetheheating questions about your existing regimen. effects of exercise. Pre-cooling may increase the time it takes for the core Find the strategies that work best for body temperature to rise. To preyou this summer and beat the heat so it cool yourself, get into a bathtub of doesn't beat you. cool water. The water temperature should be comfortably lukewarm to 20 MSConnection � SuMMEr 2010 It's time to get out and about this summer. The good news for travelers with disabilities: there are plenty of free resources available to help you plan a fun, accessible getaway. TRAVEL SITES HELP YOU SEE THE SIGHTS BaNk wITHouT BrEakING THE s tartbyvisitingTravelTex.com,theofficialsite forTexastourism.Youcanfindseveralevents and activities across the Lone Star State that suit your interests, including regional festivals, concerts, rodeos, shopping and more. TravelTex. com also includes an interactive state map, trip planners and helpful information on available accommodations. When you visit TravelTex.com, you can request a free Texas State Travel Guide, a 272-page guide packed with information on more than 400 cities, towns and attractions, with special sections on Lone Star lakes and state parks. Our stately next-door neighbors to the east also have great destinations and good times in store. VisitLouisianaTravel.com,theofficialsiteofthe LouisianaOfficeofTourism.Oncethere,youcan order a free 170-page Louisiana Visitor Guide to help you plan a trip and navigate before you go. The LouisianaTravel.com site also hosts resources on upcoming festivals, attractions throughout the state, ADA-compliant lodging and more. In addition, you can read the updated Louisiana travel blog and sign up for travel-related alerts via e-mail. You can also contact the National MS Society toll-free at 1-800-344-4867 for information on other travel-related resources. MoVING Toward a world FrEE oF MS 21 FUndraiSing Two of the National MS Society's largest fundraising events each rolled out on a bright note this spring on the road to a cure. NaTurE SMILES ON CYCLISTS SADDLING UP FOR SPRING BIKE MS moThEr F irst up was the 26th Annual BP MS 150. On April 17-18, 13,000 registered participants from around the world and 3,000 volunteers got moving on this two-day, 180-mile trek from Houston to Austin. Since its inception in 1985 with an original rider roster of 237 participants, this annual ride has become the Society's largest single fundraising event, with a 2010 target of raising $18 million. It's also become a cycling tradition, with three Day One start sites in Houston, Katy and Waller, and a massive Overnight celebration in La Grange at the Fayette County Fairgrounds. More than 150 tents covered a space of 600,000 square feet in the fairgrounds, creating a BP MS 150 city-within-a-city. Teams make up 90 percent of the participants in the annual BP MS 150. The La Grange Overnight was a welcome respite for team members to relax, refresh and recharge midway through their weekend journey. The stately Capitol in Austin served as an inspiringbackdropfortheBPMS150finish on April 18. Tens of thousands of spectators turnedouttowelcomeridersacrossthefinish. Two weeks later, on May 1-2, it was time for cyclists to saddle up and move `em out for the 2010 Bike MS: Sam's Club in North MoVING Toward a world FrEE oF MS 23 Texas. 2010 fundraisers set their sights on rounding up $2.5 million through this event. At least 3,200 registered participants, accompanied by 1,000 volunteers, mounted up for the ride through North Texas from Frisco's Dr Pepper Ballpark to downtown Fort Worth's Sundance Square. After a brief initial Day One delay while a cool front rolled through the area, providing some natural Texas air conditioning, the skies cleared and Bike MS: Sam's Club riders were ready to roll. Mother Nature's sunny disposition was complemented by rolling hills of LoneStarwildflowers,addingblooming great scenery as cyclists provided pedal power. Participants relaxed and refueled at the Bike MS: Sam's Club Overnight, located at Texas Motor Speedway, home to some of the biggest and best NASCAR racing events in the United States. The Bike MS: Sam's Club is the only ride of its kind with this special Day Two racetrack perk: cyclists get to take their own victory lap on the speedway's 1.5-mile inside track on Day Two. Riders were really revved up for this incentive and the finallegoftheride , into Fort Worth. During the cattle drives of the late 1800s, Fort Worth was one of the major stops on the legendary Chisholm Trail. On May 2, activity focused on trail riders of a different sort: participants in the 2010 Bike MS: Sam's Club, who whooped and holleredacrossthefinishintoCowtown. Finish lines in Austin and Fort Worth both bubbled over with excitement, thanks to the all-volunteer Bubble Bistro, the hugely popular form of spectator hoopla. 24 MSConnection � SuMMEr 2010 Bubble Bistro maestros Nancy Gerner, Margaret Pichon and Anne Rolandfirstteamedupthreeyearsago to add something that really popped to the Society's fundraising rides. Their bubbly creation was a comfortable, tented viewing site conveniently locatedattheeventfinish line, providing a place for persons with multiple sclerosis to cheer for and support those riding in their honor. With room for at least 30 people, the brightly-colored Bubble Bistro featured cool relief from the heat, refreshments, bubble machines and plenty of enthusiasm. Participants in the annual Bike MS rides � along with San Antonio's Bike MS: Valero ride and the Bike MS: Louisiana event this October � raise funds that support breakthrough MS research and vital services for persons living with MS, includingwellnessprograms,financial assistance, career counseling, camps for those affected by multiple sclerosis, independent living programs, advocacy, educational programs and much more. While their bikes were two-tired, BP MS 150 and Bike MS: Sam's Club riders weren't too tired to keep moving for a good cause: to help everyone living with the daily challenges of multiple sclerosis. Information on all three Lone Star Bike MS events can be found online at bikeMStexas.org, with Bike MS: Louisiana information available at bikeMSlouisiana.org. You can also call the National MS Society at 1-800-344-4867 (press 2). MoVING Toward a world FrEE oF MS 25 reSearCH Study Suggests Smoking and Exposure to Epstein-Barr Virus May Interact as MS Risk Factors i n a new study, researchers show that two individual factors that were previously identifiedasincreasingthelikelihoodof developing MS � exposure to Epstein-Barr virus and tobacco smoking � may interact and multiply to substantially increase the risk of developing MS in those with both risk factors. Claire Simon, ScD, and Alberto Ascherio, M.D., DrPH, at the Harvard School of Public Health in Boston, and collaborators in AustraliaandSwedenreportedtheirfindings in Neurology in April. The results warrant confirmationinfurtherstudies. BaCkGrouNd MS is thought to occur when people whose genes make them susceptible encounter something in their environment that triggers this immune-based neurological disease. Although many genes probably contribute to susceptibility,aspecificgenethathasbeen shown to confer higher susceptibility to MS is called HLA-DR15, which helps control howtheimmunesystemidentifiestargetsfor destruction. Although many infectious agents have been investigated at various times as possible MS triggers, no single virus or bacterium has been proved to cause the disease. However, previous studies have suggested the risk of MS is increased in persons who have had a history of infectious mononucleosis � caused 26 MSConnection � SuMMEr 2010 by the Epstein-Barr virus, or EBV � or who have high levels of blood serum antibodies against EBV, which indicate past exposure to the virus. Smoking has been associated with an increased risk of developing MS, as well as the rate of MS progression. In 2008, the Harvard team found that people who had both the HLA-DR15 gene and high levels of antibodies to the Epstein-Barr virus in the blood serum were nine times more likely to develop MS than those without that gene and with low levels of viral antibodies (Neurology 2008;70:1113-18). Exploring such interactions between genes and the environment may help researchers understand what triggers MS and also may point to ways to interfere with the development of the disease. THE STudY For the newly-published study, the Harvard team investigated even more complex relationships between MS genes and risk factors. They gathered information on people with MS enrolled in the ongoing Nurses' Health Studies, a questionnaire-based longitudinal study that tracks risk factors for chronic diseases in female nurses; the TasmanianMSStudy,astudythatidentified people with MS in Tasmania; and the Swedish MS Study, in which people with MS were identifiedinanationalhealthregistry. Dr. Simon and colleagues looked at smoking history, presence of EBV antibodies in blood serum, presence of the HLA-DR15 gene and their relationship to MS risk in the combined group of 442 people with MS and 865 controls without the disease. By pooling results from each of the three studies, researchers found that each of the factors raised the risk of developing MS at levels consistent with previous studies: those with the HLA-DR15 gene were about three times more likely to develop MS than those without this gene; those with serum EBV antibodies were about two-and-a-half times more likely to develop MS than those without EBV antibodies; and those who smoked were about one-and-a-half times more likely to develop MS than those who never smoked. However, when EBV exposure was taken into account, smoking only increased MS risks among those with high levels of serum EBV antibodies. Current or previous smokers with low levels of EBV antibodies had no increased risk for developing MS, whereas current or previous smokers with the highest levels of EBV antibodies were 70 percent more likely to develop MS than those with neither risk factor. The presence of the HLA-DR15 gene variation did not appear to modify any of these effects. CoMMENT The National MS Society's Task Force on Epidemiology of MS met in 2007 to establish research priorities for epidemiologic studies that examine aspects of people who get MS for clues to its cause. Investigating the interactions of genes and environmental factors was identifiedasanimportantavenueofresearch. This current study is novel in its approach, examining possible interactions between several risk factors, rather than looking at factorsinisolation.Ifconfirmed,theresults may help to explain some of the complexities of MS, and open up new explorations into its cause and prevention. MoVING Toward a world FrEE oF MS 27 reSearCH Genetics Study of Twins Employs New Methods for Examining Causes of MS r esearchers recently reported on a new study using novel methods to compare genetic material in three pairs of identical twins, where one twin had multiple sclerosis and the other did not. The team found no evidence of any genetic differences that would explain why only one twin developed MS. The authors pointed out further experiments that might pinpoint such differences. Sergio E. Baranzini, Ph.D., with the University of California at San Francisco, and Stephen F. Kingsmore, MB, ChB, BAO, with the National Center for Genome Resources inSantaFe,reportedtheirfindingsinNature (2010;464:1351-1356). Baranzini is a Harry Weaver Neuroscience Scholar of the National MS Society; the study was funded by grants from the Society, the National Institutes of Health, Small Ventures USA Inc., A. J. Brass Foundation and the Nancy Davis Foundation. BaCkGrouNd The average person in the United States has about one chance in 750 of developing MS. The identical twin of someone with MS, who shares virtually all the same genes, has a one-in-four chance of developing the disease, 28 MSConnection � SuMMEr 2010 suggesting that some factors other than genetics are involved. Advances in technology have made it possible to examine the genetic makeup of individuals. This collaborating team decided to take advantage of these advances to developprofilesofgenesandgeneactivityof twins, and to explore whether there were any obvious differences that might pinpoint why one twin developed MS and the other did not. THE STudY The team used next generation sequencing methods, which analyze data at unprecedented speed, to screen the genetic material in three pairs of identical twins, where only one member of each pair had MS. Researchers screened the entire genome in one pair of twins; studied millions of genetic variations in all of the pairs (SNPs, or single nucleotide polymorphisms, the most common type of variation in genetic material); and studied the genetic sequences from T cells (immune cells that are key players in the immune attack on the brain and spinal cord in MS) in all pairs. Thegroupdidnotfindanydifferences in genes or gene products, using any of these methods, that would explain why one twin developed MS and the other did not. Researchers commented that further study�suchasstudyingmorespecific subsets of immune cells � might yield further information of the molecular basis of MS and its risk factors. The average person in the United States has about one chance in 750 of developing MS. The identical twin of someone with MS, who shares virtually all the same genes, has a one-in-four chance... CoMMENT This study of identical twins reveals no genetic difference between twins with and withoutMS.Thisisastrikingfinding,given thesignificantrolethatgenesplayinMS, but the study is small and the authors do cite opportunities for further study that might yield better understanding of why individuals with virtually the same genetic blueprints, such as identical twins, are at different risk for developing MS. The authors also present novel methodology for studying the genetics of disease in twins. MoVING Toward a world FrEE oF MS 29 reSearCH Study Results Show Daclizuma Reduced Disease Activity in Relapsing MS and Reveal Novel Immune Mechanism r esults of a study in which 230 people with relapsing MS taking interferon beta and having disease activity were administered one of two doses of daclizumab (Biogen Idec and Facet Biotech Corp.) or placebo show the higher dose reduced disease activity on MRI scans by 72 percent and the lower dose by 25 percent. Immune analyses show this reduction was associated with a dramatic increase in CD56bright NK cells,whichwasanunexpectedfinding. Daniel Wynn, M.D., John Rose, M.D., and colleagues published the study results in Lancet Neurology online in February 2010. WHAT iS DACLizUMAB? Daclizumab is a laboratory-created monoclonal antibody that blocks the activity of interleukin-2 receptor-alpha, a key immune activator in MS. The drug is approved for use in organ transplant rejection. In this study, among people taking 30 MSConnection � SuMMEr 2010 interferon beta and having disease activity, 78 people received 1 mg daclizumab injection under the skin every four weeks, 75 received 2 mg every two weeks and 77 received placebo for 24 weeks; they were then observed for 48 weeks afterward. The primary endpoint was total number of new or enlarged gadolinium contrastenhancing lesions (active areas of tissue damage) measured on brain MRI scans every four weeks between Weeks 8 and 24. Other outcomes included clinical scales of disease severity such as the EDSS and MS Functional Composite. In addition, the effects of daclizumab on subsets of immune cells were analyzed. After 24 weeks, compared to interferon and placebo, there was a 25 percent reduction in the number of new or enlarged areas of active damage on MRI in the 1 mg daclizumab group and a 72 percent reductioninthe2mggroup.Nosignificant improvement in clinical scales was seen in the daclizumab groups compared to the interferon/placebo group. Daclizumab was not associated with significantchangesinTcellsorBcells, known players in the MS attack. However, the number of CD56bright natural killer cells was seven to eight times higher in both daclizumab groups than in the interferon beta/ placebo group. Severe adverse events � most frequently infections � occurred in 20 of 165 (13 percent) patients in the daclizumab groups vs. four of 77 (5 percent) in the interferon beta/placebo group. All infections were treated successfully with standard therapies. Skin-related events, such as rash, occurred more frequently in the daclizumab groups than in the interferon/placebo group during Weeks 25 to 44, but the difference declined in Weeks 45 to 72. Two patients treated with daclizumab developed malignancies that appeared to be unrelated to study treatment. Daclizumab is a laboratorycreated monoclonal antibody that blocks the activity of interleukin-2 receptor-alpha, a key immune activator in MS. The drug is approved for use in organ transplant rejection. ProTECTIVE rolE IN MS In an accompanying editorial, Olaf St�ve, M.D., and Benjamin Greenberg, M.D., with The University of Texas Southwestern Medical Center at Dallas commented on the surprisingimmunologicalfindings. "The true effects of this trial and previous observations on daclizumab might be more far-reachingthantheyseematfirstglance," they wrote, noting these natural "killer" cells may actually play a protective role in MS. "These cells might actively suppress pathogenic encephalitogenic T lymphocytes [disease-causing T cells] that participate in CNSinflammation." MoVING Toward a world FrEE oF MS 31 reSearCH Drinking Milk During Pregnancy May Lower Baby's Risk of MS rinking milk during pregnancy may help reduce a baby's chances of developing multiple sclerosis as an adult, according to a preliminary study presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto. The study involved 35,794 nurses whose mothers completed a questionnaire in 2001 about their experiences and diet during pregnancy with their nurse-daughter. Of the nurses studied, 199 women developed MS over the 16-year study period. D Researchers found that the risk of MS was lower among women born to mothers with high milk or dietary vitamin D intake in pregnancy. "The risk of MS among daughters whose mothers consumed four glasses of milk per day was 56 percent lower than daughters whose mothers consumed less than three glasses of milk per month," said Fariba Mirzaei, M.D., with the Harvard School of Public Health in Boston. "We also found the risk of MS among daughters whose mothers were in the top 20 percent of vitamin D intake during pregnancy was 45 percent lower than daughters whose mothers were in the bottom 20 percent for vitamin D intake during pregnancy. "There is growing evidence that vitamin D has an effect on MS. The results of this study suggest that this effect may begin in the womb," said Mirzaei. Fortifiedmilk,fattyfishsuchassalmon and exposure to sunlight are the most important sources of vitamin D. Editor's note: This information was provided courtesy of the American Academy of Neurology. For information on the American Academy of Neurology, please visit www.aan.com. 32 MSConnection � SuMMEr 2010 reSearCH Migraine More Common in Women with MS igraine is seen more frequently in women with multiple sclerosis than those without, according to a study presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto this spring. "While having a history of migraine diagnosis was linked to MS, women with migraine need to know that over 99 percent of them will never develop MS; thus, having migraineshoulddefinitelynotbeareasonto worry about getting MS," said study author Ilya Kister, M.D., with New York University School of Medicine and a member of the American Academy of Neurology. "More research is needed since it's still not known whether migraine is a risk factor for developing MS or if it is a condition that occurs at the same time as MS." The study involved 116,678 women who were part of the Nurses' Health Study II. Of these women, 18,000 had been diagnosed with migraine at the start of the study. The women were followed every two years for 16 years. During the study, 375 women were m diagnosed with MS. Of those, 82 had reported at the beginning of the study that they had been diagnosed by a doctor with migraine. The study found that women with a migraine diagnosis at the beginning of the study were 47 percent more likely to develop MS than women without a diagnosis. The results were the same regardless of age, where they lived, Scandinavian ancestry, vitamin D levels, smoking status and body mass index. Theresearchrepresentsthefirstlarge-scale study of its kind to explore the relationship between migraine and MS. This information was provided courtesy of the American Academy of Neurology, an association of more than 22,000 neurologists and neuroscience professionals dedicated to promoting the highest quality patientcentered neurologic care. For more information about the American Academy of Neurology, visit www.aan.com. MoVING Toward a world FrEE oF MS 33 reSearCH Two published studies lend credence to the idea that neuromyelitis optica (NMO), a disease closely related to multiple sclerosis, is an autoimmune disease that targets one or more specificproteinsinthebrain.The studies provide a rationale for new treatment approaches that could have implications for treating MS. The separate studies by Jeffrey Bennett, M.D., Ph.D., with the University of Colorado Denver School of Medicine; Monika Bradl, Ph.D., with the Medical University Vienna, Center for Brain Research; and international colleagues were published in the Annals of Neurology. evidence Supports autoimmune nature of neuromyelitis optica, an MS Mimic 34 MSConnection � SuMMEr 2010 WHAT iS NMO? NMO is a disorder that until recently was often considered a variant of MS. It mainly attacks the optic nerves and spinal cord. As with MS, nerve-protecting myelin is destroyed in NMO by an immune system attack. Although antibodies are thought to play a role in MS, their important role in causing nervous system damage in NMO now appears more certain. In addition, treatment for NMO focuses onreducingcirculatingantibodies;finding better ways to distinguish between the two disorders early in the clinical course is one research goal. The second study by Dr. Bradl and team compared the ability of antibodies taken from the blood of people with NMO, MS, other neurological diseases or healthy controls to alter the course of EAE in rats. Like Dr. Bennett's team, this team found that antibodies from NMO patients whose blood was positive for aquaporin antibodies were able to alter EAE into an NMO-like disease. IMPlICaTIoNS For FuTurE MS TrEaTMENTS In an accompanying editorial, Moses Rodriguez, M.D., with the Mayo Clinic College of Medicine wrote that both studies "strengthen the argument that NMO is an immune-mediated autoimmune disease NEw FINdINGS process." NMO now becomes the only In the two new studies, researchers autoimmune demyelinating disease for which conducted a series of experiments that the protein target ("antigen") is known with help establish the role of anti-aquaporin-4 near-certainty. antibodies in the disease. This opens up possibilities for learning Inthefirst,Dr.Bennettandcolleagues how to treat demyelinating diseases in an investigated antibodies present in the spinal antigen-specificmanner.Thisapproach fluidofanindividualwhohadrecently carries the potential for stopping the experiencedafirstattackofNMOand autoimmune disease process without whose blood showed the presence of antipredisposing patients to complications aquaporin antibodies. The team explored of immune suppression, such as PML or how reactive the antibodies were toward cancer. This has strong implications for the humanaquaporin-4inlabdishes,findingthat development of future treatments for MS, most attached to aquaporin-4. which is also demyelinating and believed to Theyalsofoundthataspecificantibe autoimmune in nature. aquaporin-4 antibody could produce changes To follow up this work, the National MS in disease when injected into rats with the Society launched a study by Dr. Bennett MS-like disease EAE and could also alter the identifying other antibodies found in people underlying pathology such that the tissue with NMO, to determine their precise targets destruction resembled that in NMO. This and, by testing their impact on a mouse study was funded by the National Multiple model of MS, exploring their contributions to Sclerosis Society, MS Society of Canada and tissue damage and the possibility that some others. may play a role in MS. MoVING Toward a world FrEE oF MS 35 aSK THe PHarMaCiST FDA Approves New MS Drug Ampyra to Improve Walking by I.D. FREED, R.PH. Iheardthat4-APwasfinallyapprovedbythe Food and Drug Administration (FDA) for use by MS patients. Does this mean I can get it at any pharmacy instead of just the ones where they do compounding? for the sale of dalfampyridine (also known as 4-aminopyridine, 4-AP or fampridine) as a treatment to improve walking in patients with multiple sclerosis. It will be marketed by Acorda under the trade name Ampyra. 4-AP has been around since the 1930s, interestingly and originally used to deter birds from nesting in the eaves of tall buildings. An enterprising chemist tried to make 4-AP into a product that could be used safely by humans and pharmacists started getting prescriptions for low doses of 4-aminopyridine for their MS patients. One of the main reasons it's taken so long for Ampyra to get FDA approval is its therapeutic index (the difference between Q: A: In January, the FDA gave its approval the therapeutic level, or the amount of drug needed to get the desired effect, and the toxic level, where the drug gives undesirable effects). There isn't a very large difference between an effective dose of Ampyra and one that can trigger convulsions with no advance warning, making the dosing of the drug like walking a tightrope. The prescribing information for Ampyra warns repeatedly about the possibility of having seizures while taking Ampyra, even if you have no history of them. I can relate my own experience with the drug: My neurologist had me on 4-AP for my MS around 1991. I loved what it did for me: it gave me more energy, helped my walking and increased my tolerance to heat. After about a year, though, I started 36 MSConnection � SuMMEr 2010 having strange episodes for 45-60 seconds a couple of times a day. When I reported this to my neurologist, he had me rushed to Parkland Hospital and I was attached to an EEG monitor for 24 hours of observation. At the end of the observation, he decided I had something similar to a "short circuit" in my head, where two axons with their myelin removed were close enough to each other that signals were jumping from one axon to another. I discontinued the 4-AP and, after about a week, the episodes stopped. I'm just glad those episodes all occurred while I was at home and not behind the wheel of my car. I look back at my experience and see that the amount of 4-AP I was taking then was higher than the recommended dose now. Also, the formulation that Acorda is making is time-release, whereas the compounded version I took nearly 20 years ago was not. If I had been taking the drug as it's available now with the time-release formulation and the lower dosage as now recommended by the FDA, I probably wouldn't have had a problem. Now that dalfampyridine has been approved by the FDA, Ampyra should be appearing on pharmacy shelves by prescription only. Just don't increase your dosage on your own and, as always, listen to your doctor and pharmacist when they warn you about possible side effects. MoVING Toward a world FrEE oF MS 37 CloSing THoUgHTS Keep Moving to Propel & Support MS Research Mark Neagli RegionalExecutiveVicePresident�NationalMSSociety T he National MS Society continues to move forward for MS research and programs to help everyone living with multiple sclerosis. As we reach the midway point of 2010, tens of thousands of people have kept us moving through our Bike MS and Walk MS events that raise money for research, programs and vital services. As you've read about in this bold new issue of MSConnection, two of the largest non-profitfundraisingeventsoftheirkind in the United States rolled out in our region this spring. The Houston-to-Austin BP MS 150 in April was, as usual, a truly inspirational sight to see, and, two weeks later, we kept the movement rolling with the Frisco-to-Fort Worth Bike MS: Sam's Club ride in May. Across our region, walkers and runners in cities such as San Antonio, Baton Rouge, New Orleans, Corpus Christi, Dallas and Fort Worth also stepped up for our spring Walk MS events, bringing entire families and communities into the MS movement. The movement continues this fall with our San Antonio-based Bike MS: Valero and Bike MS: Louisiana rides, as well as with our additional Walk MS events in Austin, Harker Heights, Houston, Katy, Kemah, Sugar Land, The Woodlands and Waco. Bike MS and Walk MS generate muchneeded funds for research, programs and servicesthatbenefit400,000Americans living with multiple sclerosis, including 20,000 Texas and 4,000 Louisiana families served by the National MS Society. With the ongoing support of our participants, volunteers, donors and sponsors, we've been able to increase the percentage of funds being devoted to research, helped drive major clinical trials on new MS drugs, boostedfinancialassistanceforfamiliesliving with MS, continued to expand our roster of popular wellness and exercise programs, increased the number of scholarships awarded to college-bound students affected by MS and much more. Those are truly moving accomplishments. I look forward to seeing you at our Bike MS and Walk MS events throughout the year. By joining us, you are making a profound difference in the lives of people living with MS everywhere. Thank you for joining the MS movement. For more information on these events and to get involved as a participant, volunteer or supporter, contact the National MS Society at 1-800-344-4867 (press 2). 38 MSConnection � SuMMEr 2010 MS doesn't wait and neither should you. visit us online at JointheMovementloneStar.org and click the advocacy link in the left-hand column. You'll learn more about our advocacy efforts to help americans living with MS and how you can make a difference, for example: and Get Involved � Become an MS Advocate: Join the MS Advocacy Action Network. Respond to occasional calls to action with e-mails, letters and phone calls to policymakers, and receive advocacy updates and e-newsletters on vital MS policy issues. � Become an MS Issue Ambassador: Make two in-person visits or more per year to legislators, in addition to Advocacy Action Network activities. � Contribute to the MS Story Bank: Share your personal story about challenges you have encountered; with your permission, stories will be used to raise greater awareness of MS policy issues. MS SToPS PeoPle FroM Moving Join the Movement we eXiST To MaKe SUre iT doeSn'T. Join THe MoveMenT SIGN uP To STEP ouT aT aN uPCoMING walk MS EVENT NEar You it's time to scoot your boots, Texas! Step up for an upcoming Walk MS near you. Free registration is now open for the Fall 2010 Walk MS events. in 2009, participants in 13 walk MS communities across Texas raised more than $1.4 million to fund MS research and programs for individuals living with multiple sclerosis. WALK MS EVENTS... � Accessible and fun for the entire family � welcome leashed canine companions at some walks � Have refreshments & entertainment � Chance to earn fantastic prizes (based on individual fundraising levels) Fall SCHEdulE* September 18 Harker Heights (Carl Levin Park) October 2 Waco (Cameron Park Zoo) October 24 austin (Dell Diamond) November 6 Kemah (Kemah Boardwalk) November 13 Katy (Katy Mills Mall) Sugar Land (Oyster Creek Park) The Woodlands November 14 Downtown Houston (Downtown Aquarium) *as of press time VISIT walkMSTExAS.ORG FOR DETAiLS AND FREE REGiSTRATiON. 8111 North Stadium Drive, Suite 100 Houston, Texas 77054 MS SToPS PeoPle FroM Moving we eXiST To MaKe SUre iT doeSn'T. Join THe MoveMenT


text:
Maybe our USTA 12s aren't so bad
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Join Date: Jun 2004
Posts: 8,491
Originally Posted by
hound 109
You might be "tired" of the argument...but this thread title suggests the conventional wisdom (that their 20 y/o freshmen are better than our 18 y/o freshmen).....might be inaccurate. The 12 y/o american beat the 20 something non american. She evidently "adjusted" in the tie break, while the ITF veteran folded like a lawn chair.
The "argument" that 5 star Americans are being passed over in favor of unproven non-americans is a topic that is logical to have in a Junior Tennis Forum.
I had no idea that the UW coach was THE lightning rod coach (when I posted that she should be embarrased that she had traveled half way across the world to recruit a player who lost to a 12 y/o.). Unlike others, i could care less what the coach says. I just think she's a numnut for not snagging better players given the prestigeous school & conference & given the "cool" vibe factor that Seattle gives off to the average youngster. She could have recruited 6 Asian Americans that would have been more solid competitors (& would have loved to compete in the Pac 10 & attend UW) than the player that lost to the 12 y/o girl.
Let's look at Grace Ysidora record thus far just in the US- she has only started playing for Washington just a couple months. Here are some of the wins she has accumulated so far in this short time period:
Marina Nikolic 4 star highest national recruit ranking #67, 6-0 6-2
Makenzie Craft Univ. Georgia, 5 Star highest national recruiting rank #13, 6-3, 2-6, 6-4
Alice Duranteau 26-10 record last season playing for Cal- Berkeley 6-4, 6-3
Marianne Jodoin (Duke) ranked #27 6-4, 6-3
Named University of Washington Student athlete of the week for going undefeated in the USTA Collegiate Invitational in Portland in singles and doubles.
Yes she lost to a 12 year old, but are there any US 4 star players who could do this? I highly doubt it. I will bet she will turn out to be one of the UWs top players by the end of the season.
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Jennifer Lawrence may be a Golden Globe winner, but she's still a giddy 22-year-old when it comes to her childhood crush. During her visit on Conan O'Brien's show, the 'Silver Linings Playbook' actress spoke about her awkward encounter with '90s heartthrob John Stamos at a party.She said, "He was at a party, and I turned into a perverted guy.
"I was like following him into rooms and staring at his ass."
Like all girls growing up in the '90s, Jennifer had a crush on the charming Uncle Jesse from 'Full House' – so it was not surprising that seeing John in real life would make her giddy. She added, "I lost my mind. And I got so upset - I didn't want to meet him because when I meet people it's never good, and I was avoiding him.
But then my friends brought him over because my friends are jerks, and I started really freaking out. And he asked me if I was on mushrooms and I said, 'No. I'm dead sober. This is just me.'"
John, 49, was completely unaware of Jennifer's crush until his pal Nick Jonas pointed it out on Twitter. Nick wrote, "@JohnStamos gets a shout out from Jennifer Lawrence on Conan... I envy you uncle Jesse. (sic)"
John tweeted soon after, "for the first time i was totally oblivious (sic)."
You never know, John, now that Jennifer has split from her boyfriend Nicholas Hoult, it may be time to make a move!


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most years funny things happen on holiday what things have happened to you
When I was in China, we had a girl from the school we visited (I was in Hong Kong for 2weeks as part of an exchange and we visited a school in china which we donated money to) show us around her house and home town.
Her english wasnt very good, and she said she was 'taking us to the book shop, where you get your hands washed' we where a bit puzzled but followed her... It turned out we where going to her sister's hair salon to meet her and see where you get your hair washed
This was at Typhoon Lagoon and my DH doesn't swim . We had gone on the lazy river and I had floated on a head of him . I looked back too see his water shoes flopping about . I panicked realizing he was lying backwards with his head under water . I jumped off my tube and struggled past other tubers with my tube in hand to get too him . By the time I had , he had gotten himself off the tube and he was only in deep knee,(not even) water . The look on his face as he looked down was priceless . We both stood against the wall and laughed tears as other tubers floated by .
I will try and explain as it related to Sign Language....
We were at the Guest Service at MK to collect our MNSSP Tickets.
The cast member who is giving us ticket is Japanese and she gesture 'firework' type of sign (which start with fist then open palm upward to reveal fireworks) we both 'translated' this as firework. We worked out that she was trying to tell us the best place to view the fireworks.
We remarked how kind of her.
Judging by her facial expression, perhaps it is not what she meant but she kept repeating about three times and we were pointing the map to try and find out the best seat.
It turned out that it was Japanese sign for 'Congratulations' as we had 'just married' badge on!!!!
We felt so stupid!
Originally Posted by Crazycatlady, post: 223080
FLORIDA VIDEOS HERE.... https://www.youtube.com/user/isafari...?feature=watch


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Welcome to MINT State! We are a PSA Authorized Dealer and specialize in low population PSA NM-MT 8, MINT 9, and GEM MT 10 vintage football, basketball, and baseball cards. We also sell high-grade complete sets, "raw" cards, and unopened packs. MINT State has helped build some of the finest sets and collections ever assembled and we welcome all want lists. Our web site is updated once or twice each week due to our ever-changing inventory, and we invite you to sign up for our mailing list.
If you wish to purchase an item listed on our web site or have any questions, please contact us at (630) 365-9790 or send us an email at firstname.lastname@example.com. Shipping and insurance is an additional $5.00 and Illinois residents pay 7.0% sales tax. We accept VISA, MasterCard, PayPal, checks, money orders, wire transfers, and in-person cash payments.
MINT State is proud to be an eBay PowerSeller and you can view our current auctions by clicking here.
Looking to sell your high-end cards, sets, or unopened packs? MINT State is always buying! We pay more for MINT and GEM MT football and basketball cards than anyone else in the hobby, and MINT State also offers an aggressive consignment package. Each transaction is completely confidential and payment is in any desired form.
or information regarding consignments.
Web Site Updated: May 26, 2015
MINT State is featuring a phenomenal run of 1948 Leaf football cards, one of the most condition-sensitive regular issues regardless of sport. Featured this week is the rookie card of Washington Redskins icon and Hall of Famer, Sammy Baugh. "Slingin' Sammy" was not only a pioneering quarterback of the modern passing game, but his 51.4 yard punting average in 1940 still stands as the single-season record. The key to the set and one of the most desirable and valuable football rookie cards in the hobby, virtually perfect centering highlights this PSA NM-MT 8!
MINT State Inc. 524 Cambridge Avenue Elburn, IL 60119-8348 (630) 365-9790
® 2015 MINT State Inc. All Rights Reserved.


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Opinion: Public Data, Private Concerns
May 20, 2015|
Research participants aren't always clear on open data policies when consenting to studies.
May 20, 2015|
Research participants aren't always clear on open data policies when consenting to studies.
May 18, 2015|
Evidence-based medicine advocate David Sackett has passed away at age 80.
May 14, 2015|
An 11-gene set may help identify sepsis early, before it's too late.
May 13, 2015|
Researchers tweak gene expression in chicken embryos that may have been crucial to the evolutionary transition from dinosaur noses to bird bills.
May 5, 2015|
Participants of two gene-therapy trials who experienced partial restoration of sight following treatment are now losing their vision once again.
May 5, 2015|
Participants in controversial cancer trials have "resolved and settled all claims against" Duke University and oncologist Anil Potti, who previously admitted to fraud, lawyer says.
May 4, 2015|
Cytoskeleton specialist Alan Hall was best known for unpacking the roles of Rho GTPases.
May 1, 2015|
An animated primer on the harvesting, growth, and administration of cardiac cells to heart attack patients
May 1, 2015|
As researchers conduct the most rigorous human trials of cardiac cell therapies yet attempted, a clear picture of whether these treatments actually work is imminent.
April 30, 2015|
Researchers inject retinal support cells derived from human embryonic stem cells into the eyes of four men with macular degeneration, bolstering evidence of the experimental treatment's safety.


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- Filed Under
The Newark Parks and Recreation Department is hosting a "Take a Child Fishing Day" event Wednesday at T.J. Evans Park at 1480 Mount Vernon Road in Newark. Registration is free and includes a picnic lunch for all children who participate in the event.
The event begins with registration at 9 a.m. at shelter house No. 3, and concludes with the lunch at noon.
Parents and children will need to provide their own fishing poles, bait and tackle for the event.
For more information, call 740-670-7782.


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From the article: Corn Mazes in Wisconsin
Have you ever been to a corn maze in Wisconsin? Can you recommend a particularly exciting or unique corn maze? How about one to avoid? Do you know of a corn maze that is not listed in our ? Please help us get the lowdown on the most amazing corn mazes. Take a minute to share your thoughts, recommendations, kudos and brickbats.
Glacier Rock Farms
- Glacier Rock Farms just north of Oconomowoc is our favorite. We have gone for 3 years in a row and each year is fun. They also have hayrides and pony rides and pumpkins and such for sale. And a FREE petting farm for my younger kids. Always a fall trip for our family
- —Guest Guest Lily
Schuett Farms, SE WI near Mukwonago,2010
- http://schuettfarm.com Fun Maze! Find all six scarecrows in the maze and you're able to enter a weekly contest for $!! Bring a snack and water when you go in, you might be in there a while as it is not easy if you are determined to find all six scarecrows (they're seated!). Beautiful farm! Tractor pulled hay rides, $4. Maze, $4 Gourds, pre-picked and pick your own pumpkins for sale. A fantastic array of normal and bizzare pumpkins for sale(surprisingly weird pumpkins!) Guess the weight of the gigantic pumpkin contest. A fun afternoon!
- —ScatterHeart
Awsome Family Corn Maze
- Day maze on the weekends for Sept, then night maze, before the haunted the last 2 weekends in Oct. rates and hours 715-927-1228--Wausaukee, WI
- —Ramses74
Awsome Family Corn Maze
- Day maze on the weekends for Sept, then night maze, before the haunted the last 2 weekends in Oct. rates and hours 715-927-1228--Wausaukee, WI
- —Ramses74
Schopf's Hilltop Dairy
- Schopf's in Sturgeon Bay is my family's favorite. We've tried others, but this has been, by far, the most challenging.
- —Guest demerson
Meuer Farm corn maze
- Meuer Farm with a corn maze, mini mazes, hayrides and much more is a blast for all family memebers. A great place for "good farmin' fun.
- —wmeuert


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Acer (maple) is a genus of trees or shrubs. They are variously classified in a family of their own, the Aceraceae, or (together with the Hippocastanaceae) included in the family Sapindaceae. Modern classifications, including the Angiosperm Phylogeny Group classification, favour inclusion in Sapindaceae. There are approximately 125 species, most of which are native to Asia, but several species also occur in Europe, northern Africa, and North America.Maple trees roots go from about 5 meters to 30 meter.
The word Acer is derived from a Latin word meaning "sharp" (referring to the characteristic points on the leaves) and was first applied to the genus by the French botanist Joseph Pitton de Tournefort in 1700. The type species of the genus is Acer pseudoplatanus (Sycamore Maple).
Maples are mostly trees growing to 10-40 meters (30-130 ft) in height. Others are shrubs less than 10 metres tall with a number of small trunks originating at ground level. Most species are deciduous, but a few in southern Asia and the Mediterranean region are evergreen. Most are shade-tolerant when young, and are often late-successional in ecology; many of the root systems are typically dense and fibrous. A few species, notably Acer cappadocicum, frequently produce root sprouts, which can develop into clonal colonies.
Maples are distinguished by opposite leaf arrangement. The leaves in most species are palmate veined and lobed, with 3-9 (rarely to 13) veins each leading to a lobe, one of which is central or apical. A small number of species differ in having palmate compound, pinnate compound, pinnate veined or unlobed leaves. Several species, including Acer griseum (Paperbark Maple), Acer mandshuricum (Manchurian Maple), Acer maximowiczianum (Nikko Maple), and Acer triflorum (Three-flowered Maple), have trifoliate leaves. One species, Acer negundo (Box-elder), has pinnately compound leaves that may be simply trifoliate or may have five, seven, or rarely nine leaflets. A few, such as Acer laevigatum and Acer carpinifolium (Hornbeam Maple), have pinnately-veined simple leaves.
The flowers are regular, pentamerous, and borne in racemes, corymbs, or umbels. They have four or five sepals, four or five petals about 1–6 mm long (absent in some species), four to ten stamens about 6-10 mm long, and two pistils or a pistil with two styles. The ovary is superior and has two carpels, whose wings elongate the flowers, making it easy to tell which flowers are female. Maples flower in late winter or early spring, in most species with or just after the leaves appear, but in some before them.
Maple flowers are green, yellow, orange or red. Though individually small, the effect of an entire tree in flower can be striking in several species. Some maples are an early spring source of pollen and nectar for bees.
The distinctive fruit are called samaras or "maple keys". These seeds occur in distinctive pairs each containing one seed enclosed in a "nutlet" attached to a flattened wing of fibrous, papery tissue. They are shaped to spin as they fall and to carry the seeds a considerable distance on the wind. Children often call them "helicopters" due to the way that they spin as they fall. Seed maturation is usually in a few weeks to six months after flowering, with seed dispersal shortly after maturity. However, one tree can release hundreds of the seeds at a time. Depending on the species, the seeds can be small and green to yellow and big with thicker seed pods. The green seeds are released in pairs, sometimes with the stems still connected. The yellow seeds are released individually and almost always without the stems. Most species require stratification in order to germinate, and some seeds can remain dormant in the soil for several years before germinating.
The genus is subdivided by its morphology into a multitude of sections and subsections.
The leaves are used as a food plant for the larvae of a number of Lepidoptera species (see List of Lepidoptera that feed on maples). Aphids are also very common sap-feeders on maples. In horticultural applications a dimethoate spray will solve this.
Maples are affected by a number of fungal diseases. Several are susceptible to Verticillium wilt caused by Verticillium species, which can cause significant local mortality. Sooty bark disease, caused by Cryptostroma species, can kill trees which are under stress due to drought. Death of maples can rarely be caused by Phytophthora root rot and Ganoderma root decay. Maple leaves in late summer and autumn are commonly disfigured by "tar spot" caused by Rhytisma species and mildew caused by Uncinula species, though these diseases do not usually have an adverse effect on the trees' long-term health.
Maple collections, sometimes called aceretums, occupy space in many gardens and arboreta around the world including the "five great W's" in England: Wakehurst Place Garden, Westonbirt Arboretum, Windsor Great Park, Winkworth Arboretum and Wisley Garden. In the United States, the aceretum at the Harvard-owned Arnold Arboretum in Boston is especially notable. In the number of species and cultivars, the Esveld Aceretum in Boskoop, Netherlands is the largest in the world.
The particularly spectacular fall colours of the Acer rubrum (Red Maple) are a major contributor to the seasonal landscape in southeastern Canada and in New England. Fall tourism is a boon to the economy of this region, especially in Quebec, Vermont, New Hampshire and Western Massachusetts. In the American Pacific Northwest and British Columbia it is the spectacular fall colours of Acer circinatum (Vine Maple) that draw tourists and photographers.
Some of the larger maple species have valuable timber, particularly Sugar Maple in North America, and Sycamore Maple in Europe. Sugar Maple wood, often known as "hard maple", is the wood of choice for bowling pins, bowling alley lanes, pool cue shafts, and butcher's blocks. Maple wood is also used for the production of wooden baseball bats, though less often than ash or hickory due to the tendency of maple bats to shatter when broken.
Some maple wood has a highly decorative wood grain, known as flame maple and quilt maple. This condition occurs randomly in individual trees of several species, and often cannot be detected until the wood has been sawn, though it is sometimes visible in the standing tree as a rippled pattern in the bark. Birdseye maple is another distinctive grain pattern.
Most drums are made from maple. From the 70s to the 90s, maple drum kits were a vast majority of all drum kits made. In recent years, Birch has become popular for drums once again. Electric guitar necks are commonly made from maple. The necks of the Fender Stratocaster and Telecaster were originally an entirely maple one piece neck, but later were also available with rosewood fingerboards. Maple fingerboards have a brighter sound than rosewood.
The tops of Gibson's Les Paul guitar are made from carved maple. Many Les Pauls have quilted or flamed maple tops, and these models are particularly prized by players and collectors. Very few solid body guitars are made entirely from maple, as it is considered too heavy. Many guitars do, however, have maple tops or veneers. Gibson uses laminated maple in the manufacture of many of its semi-hollowbody guitars.
Maple is also used to make bassoons and double basses.


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What Goes With a Black Suit? When Do You Wear One?
I've been considering a black suit, but I'm not sure what outfits to wear it with. Is it only good for formal situations?
Posted by menstyleqa on Mar 19, 2012 in Men's Clothing, Men's Suits | 4 comments
I've been considering a black suit, but I'm not sure what outfits to wear it with. Is it only good for formal situations?
In general you can wear a black suit the same way you would a charcoal gray or dark navy one. It's business dress, goes well with a white shirt and tie, and is suitable for pretty much any level of formality short of formal (black tie) occasions. It also works as a non-tuxedo option for "black tie optional" invitations.
Worth considering: it looks a little stark and isn't as versatile as the more neutral charcoal gray. Since a suit is expensive and the two fill the same role, you're usually better off buying charcoal unless you already have one and are looking for variety. Pale-skinned men also look worse in pure black, especially under fluorescent lighting.
We did a video specifically on the pros and cons of buying a black suit for our Real Men Real Style YouTube channel:
Here's some more information about what to consider when getting a black suit – http://www.mademan.com/mm/what-wear-black-suit.html
Antonio wrote an article – "Men's Suit Colors: A Man's Guide to the Black Suit" over at A Tailored Suit. Here's the link http://www.atailoredsuit.com/mens-black-suit.html – This is also in support to his "Should a Man Buy a Black Suit?" video. I hope this helps!
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Cod Steaks Topped with Tomato and Basil
|Olive oil
|2 Teaspoon
|1 Pound, coarsely chopped
|Loosely packed basil leaves
|3⁄4 Cup (12 tbs), chopped
|Medium dry sherry
|3 Tablespoon
|1⁄8 Teaspoon
|Black pepper
|1⁄4 Teaspoon
|Cod steaks
|1 1⁄4 Pound, central bones removed (4 Steaks)
1. Preheat the grill. Cut out four 12 x 16-inch pieces of heavy-duty foil. Brush the olive oil over the foil.
2. In a bowl, combine the tomatoes with the basil and sherry, and season the mixture with the salt and pepper.
3. Lay a cod steak in the center of each piece of foil and top it with one-fourth of the tomato mixture. Bring the two short sides of the foil together and fold over as you would to wrap a sandwich. Fold in the ends to seal the packets.
4. Place the packets on the grill and cook for 3 to 5 minutes. Carefully turn and cook for 5 minutes on the second side.
5. Unwrap the packets with the tomato-side up and slide the contents of each one onto an individual plate. Remove and discard the thin strips of cod skin and serve the steaks at once.


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Hello ladies,
I was hoping I could get some insight on how other mothers felt when they found out what they were having and it wasn't the sex you were hoping for. Ever since I got pregnant, I felt like I was having a girl and had my heart set on having her. I just had my 20 week ultrasound and to my surprise, it's a boy. I cried all day long and I feel like I am going to be a bad mother because I strongly felt like he was a girl this whole time
Similar stories or comforting advice would be greatly appreciated.


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ABC's Hit TV Show Gets Extreme Wi-Fi Makeover
SUNNYVALE, Calif., Aug. 16 /PRNewswire/ — Ruckus Wireless(TM) today announced that "Extreme Makeover: Home Edition" (EMHE), ABC's popular television show that builds new homes for families in need, has chosen and deployed the Ruckus ZoneFlex Smart Wireless LAN (WLAN) system for use on production sets throughout the United States of America.
ABC's Extreme Makeover: Home Edition show is using Ruckus dual-band, outdoor 802.11n Smart Wi-Fi products and technology to provide reliable wireless service and coverage spanning areas from several acres to multiple city blocks.
The show relies heavily on outdoor wireless Internet connectivity to support film and production crews, design teams and other onsite guests and staff. But given the dynamic nature of the environment, EMHE required a faster, more reliable and longer range Wi-Fi system.
For EMHE, the new Wi-Fi network needed to be able to cope with ever-changing environmental conditions, and provide strong signals that are typically subject to large amounts of interference from trees, neighboring houses, dozens of RVs, trucks and other machinery moving in and out of the "hero home" location.
According to show organizers Wi-Fi has become a necessity for collaboration between the on-site production crew and post-production teams at the network's corporate offices in Los Angeles, as well as for email communications, printing, researching designs online, and various other types of paperwork.
One "root" AP provides smart mesh connectivity to three mesh APs that surround the makeover site. This eliminates the need to pull Ethernet cabling and provides non-stop operation of the network. In the event of a failed AP, the smart mesh network automatically reroutes long-range Wi-Fi connections using intelligent radio frequency technology to ensure constant connectivity.
Unlike conventional Wi-Fi products, the Ruckus Smart Wi-Fi system uses patented smart antenna array technology to deliver longer range Wi-Fi connections that are continually "steered" around obstacles and interference as they are experienced. Consequently, as client devices change their orientation or move, or as potential interference is encountered, the Ruckus technology ensures the highest possible data rate and lowest packet error rate. This results in greater Wi-Fi coverage, better reliability and more consistent performance everywhere. Additionally, Ruckus' smart meshing capability provides reliable wireless connectivity to areas where Ethernet cabling is not possible.
Extreme Makeover Gets an Extreme Upgrade with Smart Wi-Fi
The Ruckus network now blankets the entire area of the most recent production set with solid Wi-Fi – even in the farthest corners that never before could get a signal.
The entire network can be set up in just one hour. "It's amazing what this will mean for our team's productivity," said Diane Kormarn, senior producer for EMHE. "Our crew is simply amazed at what great coverage they have while on location."
To cover the multi-acre site, EHME deployed four dual-band 802.11n ZoneFlex 7762 outdoor APs, mounted on 16-foot poles. One root AP is connected to the Internet via a 25-50Mbps DSL circuit connects wirelessly to three mesh APs over long range, non-line of sight 5GHz connections, while the 2.4GHz radio serves hundreds of onsite laptops and handheld devices.
The EMHE network is configured with multiple virtual wireless LANs. One secure SSID provides access for the production crew, offering unrestricted bandwidth use. Another SSID is provided for public use by outsiders or random vendors needing short-term access. The secure SSID uses WPA2 for authentication, and also allows for airtime fairness for a mix of 802.11a/b/g/n devices accessing the network. For the open public networks, bandwidth thresholds per user are set to ensure equal allocation of bandwidth among all users.
About Ruckus Wireless, Inc.
Headquartered in Silicon Valley, Ruckus Wireless is supplier of advanced wireless systems for the mobile Internetworking market. The company markets and manufactures a wide range of indoor and outdoor "Smart Wi-Fi" products for mobile operators, broadband service providers and corporate enterprises around the world. Since 2006, the company has realized record revenue and shipments with a CAGR of over 119% percent. Ruckus invented, and has patented, state-of-the-art wireless technology that steers Wi-Fi signals around obstacles and interference. This unique capability extends signal range and ensures consistent reliable distribution of delay-sensitive multimedia content and services over standard 802.11 Wi-Fi. The company has shipped over 2 million Smart Wi-Fi systems around the world and has raised $51 million in funding from premier investors such as Sequoia Capital, Focus Ventures, Sutter Hill, Motorola, T-Ventures, Telus Ventures and Firelake Capital. The company is led by Ms. Selina Lo, president and chief executive officer. For more information, visit Ruckus Wireless at http://www.ruckuswireless.com.
About Extreme Makeover: Home Edition
The Emmy award winning reality program "Extreme Makeover: Home Edition," now entering its 8th season, is produced by Endemol USA, a division of Endemol Holding. It's executive-produced by Brady Connell and George Verschoor. David Goldberg is Chairman, Endemol North America. The show airs Sundays from 8:00-9:00 p.m., ET on ABC.
Media Contacts Nancy MacGregor Hill RealTime Communications firstname.lastname@example.com +1-510-733-6228 office +1-415-309-5185 mobile
SOURCE Ruckus Wireless