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Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma
The Fast Track program is designed to expedite the review of investigational drugs for the treatment of patients with serious or life-threatening diseases where there is an unmet medical need. Fast Track designations allow a company to file a New Drug Application (NDA) or Biologics License Application (BLA) on a rolling basis and permit the FDA to review the filing as it is received, rather than waiting for the complete submission prior to commencing the review process. Additionally, NDAs and BLAs for fast track development programs are eligible for priority review which may result in an abbreviated review time of six months.
Additional Clinical Updates
Agennix also announced that two pivotal Phase III trials in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) are underway at a number of leading U.S. clinical sites. FORTIS-M is a randomized, placebo-controlled, 720-patient trial of talactoferrin monotherapy in patients with Stage IIIB/IV NSCLC. Patients who have failed two or more prior systemic anti-cancer therapies will be randomly assigned (2:1) to receive either oral talactoferrin or placebo in additional to standard supportive care. The trial is designed to detect an improvement in overall survival in patients receiving talactoferrin, and results are expected in 2011.
FORTIS-C is a randomized, placebo-controlled trial evaluating 1100 chemo-naive NSCLC patients. Newly diagnosed patients with Stage IIIB/IV NSCLC will be randomly assigned (1:1) to receive standard first-line chemotherapy with carboplatin and paclitaxel plus either oral talactoferrin or placebo. Agennix has received Fast Track designation from the FDA for both NSCLC indications as well as favorable Scientific Advice from the EMEA. Agennix has also received approval of a Special Protocol Assessment from the FDA for the FORTIS-C trial. The designs of these two Phase III trials are based on previous successful randomized, placebo-controlled, Phase II trials which both met their primary endpoint with supporting results on the secondary endpoints.
"We are pleased with the continued development progress with talactoferrin including our most recent Fast Track designation and the initiation of our Phase III NSCLC trials," said
About Talactoferrin
Talactoferrin is a novel targeted dendritic cell recruiter and activator (DCRA) being studied for the treatment of several life-threatening diseases including RCC and NSCLC. Talactoferrin mediates its anti-cancer activity by targeting dendritic cells which play an important role in activating innate and adaptive immunity. After being transported into the gut associated lymphoid tissue (GALT), the largest immune organ in the body, orally administered talactoferrin induces the recruitment of immature dendritic cells to the GALT and promotes their maturation. This unique aspect of its function results in recruitment of dendritic cells that have captured tumor antigens while in the peripheral circulation. Following maturation, these dendritic cells activate Natural Killer (NK) and Natural Killer T-cells (NK-T) of the innate immune pathway and CD8+ lymphocytes of the adaptive immune pathway. Initiating the immune response in the GALT, and away from the tumor, reduces the effect of anti-immune factors produced by the tumor.
Talactoferrin Fast Track Designations
Agennix has received Fast Track designation for talactoferrin for the first-line treatment of RCC in combination with sunitinib. Agennix's RCC submission included the results from a Phase I trial, and a multi-center, single arm Phase II trial of talactoferrin in 44 patients with clear cell RCC who had failed standard therapy. Patients receiving oral talactoferrin in this Phase II trial had a median progression-free survival of 6.4 months, median overall survival of 21.1 months, and a one-year survival rate of 77%. Talactoferrin appeared to be well tolerated, which was consistent with other talactoferrin studies. The results from the Phase II trial were published in Cancer in 2008.
Talactoferrin was previously awarded Fast Track designations in NSCLC both for first line treatment and for patients who have failed two or more prior systemic anti-cancer therapies. These NSCLC Fast Track designations were based upon the clinical activity and tolerability data from two randomized placebo-controlled Phase II trials. Both Phase II trials met their primary endpoint with supporting results on the secondary endpoints.
About Renal Cell Carcinoma (RCC)
RCC is the most common type of kidney cancer, accounting for approximately 90 percent of kidney tumors. According to the American Cancer Society, there are approximately 49,000 new cases of kidney cancer diagnosed each year in
About Agennix
Agennix is a private biopharmaceutical company developing a first-in-class molecule with immunological activity for the treatment of cancer and other unmet medical needs. Agennix's lead molecule, talactoferrin, is an immunomodulatory protein with a novel mechanism of action. The Company is developing an oral liquid formulation of talactoferrin for cancer indications and a topical gel formulation for the treatment of diabetic foot ulcers. Agennix has more than 90 issued patents and more than 50 pending patents broadly protecting talactoferrin. Agennix has recently initiated Phase III trials in two non-small cell lung cancer indications (talactoferrin monotherapy in patients who have failed two or more previous therapies, and talactoferrin in combination with chemotherapy in previously untreated patients), and is planning a Phase IIb trial in patients with renal cell cancer, and Phase II trials in other cancer indications.
The company has recently agreed to merge its business with GPC Biotech, a publicly traded biopharmaceutical company focused on developing anti-cancer drugs. The merger is subject to the approval of the shareholders' meeting of GPC Biotech and to further closing conditions, and is expected to be completed by the end of 2009.
More information about Agennix is available on the Company's web site at http://www.agennix.com.
Forward Looking Statements
This press release contains forward-looking statements, which express the current beliefs and expectations of the management of Agennix. Such statements are based on current expectations and are subject to risks and uncertainties, many of which are beyond our control, that could cause future results, performance or achievements to differ significantly from the results, performance or achievements expressed or implied by such forward-looking statements. Actual results could differ materially depending on a number of factors, and we caution investors not to place undue reliance on the forward-looking statements contained in this press release. There can be no guarantee that the merger with GPC Biotech will be completed. Forward-looking statements speak only as of the date on which they are made and Agennix undertakes no obligation to update these foward-looking statements even if new information becomes available in the future.
SOURCE Agennix


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Home > Health & Fitness > Healthwise > Lipid Panel
A lipid panel is a blood test that
lipids—fats and fatty substances used as a source of
energy by your body. Lipids include
high-density lipoprotein (HDL), and
low-density lipoprotein (LDL).
panel measures:
Other measurements that may be done for a lipid panel
Lipids are found in your blood and are stored in tissues.
They are an important part of cells, and they help keep your body working
Lipid disorders, such as high cholesterol, may lead to
life-threatening illnesses, such as
coronary artery disease (CAD),
heart attack, or
Your doctor may order a lipid
panel as part of a regular health examination. Your doctor may use the results
of this test to prevent, check on, or diagnose a medical condition.
Follow your doctor's instructions on how to prepare for this test. If your doctor tells you to fast before your test, do not eat or
drink anything except water for 9 to 12 hours before having your blood drawn.
Usually, you are allowed to take your medicines with water the morning of the
test. Fasting is not always necessary, but it may be recommended. Do not eat high-fat foods the night before the test. Do not drink alcohol or exercise strenuously before the
If your doctor
finds a lipid disorder, treatment may be started to help lower your blood lipid
levels. Your treatment could include medicines, diet changes, weight loss, and
To learn more, see the topic
Cholesterol and Triglyceride Tests.
Other Works Consulted
Chernecky CC, Berger BJ (2013). Laboratory Tests and Diagnostic Procedures, 6th ed. St. Louis: Saunders.
Fischbach FT, Dunning MB III, eds. (2009).
Manual of Laboratory and Diagnostic Tests, 8th ed.
Philadelphia: Lippincott Williams and Wilkins.
Stone NJ, et al. (2013). 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation, published online November 12, 2013. DOI: 10.1161/01.cir.0000437738.63853.7a. Accessed November 18, 2013.
ByHealthwise StaffPrimary Medical ReviewerE. Gregory Thompson, MD - Internal MedicineSpecialist Medical ReviewerRakesh K. Pai, MD, FACC - Cardiology, Electrophysiology
Current as ofFebruary 20, 2015
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This mouth-watering tangerine mousse with rhubarb sauce is light enough to indulge in seconds.
For the sauce:
Boil the 375g rhubarb with the sugar and water for 5 minutes, skim and pass.
Discard the pulp. Add the scraped vanilla pod to the syrup and bring back to the boil. Add the trimmed lengths and poach for 1 minute – leave to cool, then chill.
For the mousse:
Heat the tangerine juice with half the zest until it reduces to 30-40ml. In another pan bring the water and sugar to the boil to dissolve and add the juice mixture. It should have a consistency of marmalade.
Bring the egg yolks to a light and fluffy state over hot water, continue to beat and add (slowly) the juice mixture. Remove from the heat and continue beating till cold with a hand whisk. Whip the cream to soft peaks and fold into the egg mixture. Fold the other half of the zest into the mixture. Pour into 6 ramekins or suchlike and freeze for 6 hours.
To serve, divide the sauce between 6 soup plates and dip each of the moulds in very hot water and set in the middle of each. Dust with icing sugar and serve.
» Metric Converter
Sparkling Whites, Pinot Gris and Dessert Wines are the best wines to pair with Tangerine mousse With rhubarb sauce.
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Reykjavík City Hostel is right in the heart of Laugardalur Park, next door to the national sport stadiums and Iceland's biggest pool and spa. It's a 30 minute walk to the city centre along the scenic Reykjavík coastline, or 10 minutes by bike or bus.
The hostel offers 4 to 6 bedded rooms with private and shared bathrooms, and comfortable double/twin rooms with private bathrooms. Enjoy free Wi-Fi, treat yourself to a drink at the coffee bar, or make use of three fully equipped kitchens, dining area and laundry facilities. The breakfast buffet also makes for a good start to the day.
Reykjavík City Hostel are happy to help you get around this amazing city and recommend excursions including the Northern Lights, The Blue Lagoon spa and husky and glacier tours.
What travellers think
I didn't know what I supposed to expect before my arrival. However my first impression was very good. The room was nice and the bathroom was huge :) Maybe only the ceiling could be painted like the walls, but it's only my own suggestion ;)
Sat 23 May 2015
Travel tips...
Budget meal tip
La panière Free Food dans la cuisine ;)
Tue 22 Apr 2014
Nightlife & entertainment tip
Baladez-vous dans la rue principale de la ville, tout simplement !
Tue 22 Apr 2014


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Sig Sauer MPX 8" 9mm Pistol
Sig Sauer MPX Pistol, 9mm, 8" ...$1,449.00
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Sig Sauer MPX Magazine Pouch - Black
Sig Sauer MPX Magazine Pouch, Belt ...$34.99
Sig Sauer Match Grade OTM 125gr .300 BLK - 20RD
Sig Sauer Match Grade, .300 BLK, ...$23.63
Sig Sauer SRD22 Rimfire Silencer - NFA Item
Sig Sauer SRD22 Rimfire Silencer, .22LR, ...$399.00
New at SigSauerGuns.com
Sig's MPX is shipping! Sig has started shipping two variants of the MPX pistol both with and without the pistol brace. Jump over to the product page to see the MPX product listing to see pricing, stock status, and subscribe to stock notifications.
Sig Pistol Rebate for May 2015
Sig is running a mail in rebate program for the month of May. See details on the rebate in our news section.
Stock up on Sig Sauer Magazines!
We are stocking nearly every available magazine for ever firearm produced by Sig Sauer. We carry high capacity magazines as well as state compliant magazines with a capacity of ten or less rounds for states like California or New York.
We do our best to monitor when new magazines are released and order them early so they are available when you need them! We are already starting to receive Sig's MPX magazines!
SIG-SD Suppressors
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Sidney Crosby defends decision to skip hockey world championship
Cites his need to fully recover after concussion-like symptoms limited him to 22 games in the regular season.
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PITTSBURGH—Sidney Crosby is strongly defending his decision to not play for Canada in the upcoming world hockey championship, saying he needs to go through the full summer of preparation he missed because of a concussion last year.
While Pittsburgh Penguins teammate Evgeni Malkin will play for Russia — "Really, I don't have a choice," Malkin said — Crosby declined Tuesday an invitation to play for Team Canada in Helsinki and Stockholm from May 4-20.
"Typically, I'd be there in a second, but this isn't a normal situation and this isn't me trying to hide away from the world championships," said Crosby, two days after his team was eliminated from the playoffs by the Philadelphia Flyers. "I love playing for Team Canada."
Crosby was surprised to hear that some Canadians are upset with his decision. He last played for his homeland in the 2010 Vancouver Olympics, when he scored the overtime goal that carried Canada past the United States in the gold-medal game.
"Anyone who is questioning that right now obviously doesn't know me or aren't thinking right," Crosby said. "I mean, I don't have anything to say about that."
But because he has missed so much playing time to concussion-related issues over the last two seasons — 101 games, plus the 2011 playoffs — Crosby said it is very important for him to have a healthy, regular summer of preparation. He has not played a full NHL season since 2009-10.
"I feel pretty good. (But) the last year and a half has been tough," Crosby said. "It's been tough to stay healthy. I think the best thing to do is to give myself a full summer for to get ready for next year and have a full season."
Crosby, widely considered to be hockey's premier player at the time, was leading the NHL scoring race with 66 points in 41 games when he sustained a season-ending concussion in January 2011.
Because of ongoing concussion-related symptoms — spatial issues, headaches and sensitivity to bright light and loud noise — Crosby could do little off-season training until late last summer. He was banned from contact for most of training camp, then missed the first 20 games of the season before returning with a spectacular two-goal, two-assist effort against the New York Islanders on Nov. 21.
But the 24-year-old Crosby played in only seven more games before the symptoms returned following a physical game against the Boston Bruins on Dec. 5. He was out another three-plus months, then came back to play in the Penguins' final 14 regular season games and their six-game Stanley Cup playoffs loss to the Flyers.
While he absorbed several hard hits late in the Flyers series — including an inadvertent one from Malkin — Crosby said he currently has no concussion-like symptoms.
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Click here for the iOS version, and here for Android.
What's so good?
By Jason Grishkoff | Jun 25, 2010 | Total plays: 12,798
Alan Wilkis, at it again. Turning trip-hop into sugar-pop with his instrumentally ADD'd version of Mouthful Of Diamonds by Saratoga Springs duo Josh Carter and Sarah Barthel (aka Phantogram). Becoming the "˜go-to guy for remixes among the indie sector', I'm taking this song into the weekend. - Indie Music Filter


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I haven't used it much in reciprocity situations, but when I have it holds up really well in it's own right. It also very strangely pushes without dropping shadow detail, too far and you get weird marks in the picture though.
It's a really enjoyable. Fomapan has done nothing but irritate me, however I wish to try Fomapan 400, it has a really high far red peak sensitivity with almost a straight line drop off.
Similar to Delta 400, but more extreme, and with lowered blue sensitivity.
Here's a chart I rigged up with some films for comparison of spectral sensitivity distribution. Fomapan 400 is about as opposite to Tri-X as you could get. While Plus-X has a steep drop off at the blue section.. it's about the same as a reverse of Fomapan 400 sensitivity.
Spectral Sensitivity Comparison by athiril, on Flickr


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Last month, the citizens of Okinawa awarded a landslide victory to a governor who wants U.S. troops off the pristine island.
Posts Tagged: U.S. Military Bases
Despite intense crackdowns, activists on the Japanese island of Okinawa continue to resist the construction of new U.S. military bases.
If Obama thought his short pass through Pacific would boost the much-vaunted U.S. "pivot" to Asia, he soon discovered that the world is not cooperating with his best-laid plans.
By linking itself to Washington in its territorial disputes with China, the Philippines risks getting caught up in a superpower conflict.
An AFRICOM official says the U.S. has been "at war" in Africa for over two years.
The Philippines and Vietnam are natural allies in their common territorial struggles against China. But they should leave Washington out of it.
Disaster relief has increasingly become part of the justification for increased U.S. troop deployments in the Asia-Pacific region.
As the human rights situation in the Philippines has deteriorated, U.S. military aid has ramped up.
The lumbering aircraft carrier known as the United States should be executing a pivot that lives up to its name: a shift from the martial to the pacific.
The Obama administration's "Pacific Pivot" is wreaking environmental havoc on the pristine ecosystems of the Asia-Pacific region.


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An array of Fresnel microlenses is fabricated directly on the planar output surface of an array of vertical cavity surface-emitting lasers. A compact integrated assembly comprising precisely aligned lasers and lenses is thereby provided for focusing (or collimating) the output beams of the lasers.
1. An integrated laser-lens assembly comprising an array of vertical cavity surface-emitting lasers, each of said lasers comprising an active region sandwiched between a first mirror individual to each of said lasers and a second mirror common to all of said lasers and individual electrical contacts for each of said regions,
a substrate having a high transmissivity at the wavelengths emitted by said lasers extending across said second mirror and integrally formed therewith, and
a plurality of planar Fresnel microlenses formed in the outer surface of said substrate, each of said microlenses being in alignment with the individual electrical contact of one of said vertical cavity surface-emitting lasers and comprising means defining concentric zones.
2. An integrated laser-lens assembly in accordance with claim 1 wherein said zones are defined by a patterned layer formed on said outer surface.
3. An integrated laser-lens assembly in accordance with claim 1 wherein said zones constitute depressions formed in said outer surface.
4. An integrated laser-lens assembly in accordance with claim 1 wherein at least one of said microlenses comprises a structure having multiple nested semicircular grooves having a common center that does not lie on the center line of its respective aligned laser.
5. An integrated laser-lens assembly in accordance with claim 1 wherein said microlenses are of the binary-phase type and said means defining concentric zones includes continuous vertical walls each of the same depth in said outer surface.
6. An integrated laser-lens assembly in accordance with claim 1 wherein said microlenses are of the multiple-phase type and wherein each of said zones includes a stepped wall.
This invention relates to lasers and, more particularly, to lasers of the vertical cavity surface-emitting type.
The development of vertical cavity surface-emitting lasers has made it possible to fabricate optical sources characterized by extremely small size and high output power. Additionally, multiple such sources can be conveniently integrated in a single chip to form two-dimensional arrays useful for a wide variety of optical information processing, interconnection and communication applications. Techniques for making and using such sources are well known in the art, as described, for example, in U.S. Pat. No. 4,949,350, entitled Surface-Emitting Semiconductor Laser, issued to J. L. Jewell and A. Scherer, and in an article by H. Orenstein, A. C. Von Lehmen, C. Chang-Hasnain, N. G. Stoffel, J. P. Harbison, L. T. Florez, E. Clausen and J. L. Jewell, entitled Vertical Cavity Surface-Emitting InGaAs/GaAs Lasers with Planar Lateral Definition, which appears in Appl. Phys. Lett. 56,2384 (1990).
Due to diffraction effects, the individual beams provided by the surface-emitting lasers of an integrated array exhibit a relatively high degree of divergence as they emerge from the planar output surface of the array. In practice, such divergence often causes deleterious effects such as crosstalk among the output beams to occur.
Accordingly, attempts have been made to focus or collimate the output beams of a vertical cavity surface-emitting laser array to avoid the practical problems caused by the divergence phenomenon. But heretofore all such efforts have involved the use of a separate lens array spaced apart from the laser array thereby to form a hybrid assembly for achieving the desired focusing or collimation.
The separate lens array included in such a hybrid assembly is typically bulky, difficult to fabricate, and difficult to maintain in precise alignment with the individual sources of the associated laser array. Hence, efforts have continued to try to devise other more suitable arrangements for controlling the output beams of a surface-emitting laser array. In particular, these efforts have been directed at trying to develop an easily fabricated, rugged, compact, microminiature assembly capable of both generating and shaping the laser output beams to exhibit the requisite focused or collimated shape.
In accordance with the principles of the present invention, an array of Fresnel microlenses is fabricated directly on the planar output surface of an array of surface-emitting lasers. In that way, a compact integrated assembly comprising precisely aligned lasers and lenses is provided.
In accordance with one feature of the invention, the microlenses included in the integrated assembly comprise simple binary-phase Fresnel lenses. Each such lens includes a set of concentric vertically walled grooves.
A complete understanding of the present invention and of the above and other features thereof will be apparent from a consideration of the detailed description below taken in conjunction with the accompanying drawing, not drawn to scale, in which:
FIG. 1 is a cross-sectional side view of a conventional array of vertical cavity surface-emitting lasers;
FIG. 2 is a simplified showing of an array of the FIG. 1 type modified in accordance with the principles of the present invention to form an integrated laser-lens assembly;
FIG. 3 is a bottom view of a binary-phase lens of the type included in the FIG. 2 assembly;
FIG. 4 depicts another form of binary-phase lens suitable for inclusion in the integrated assembly of FIG. 2;
FIG. 5 represents a specific illustrative multiple-phase lens that may be included in an integrated assembly of the FIG. 2 type;
and FIG. 6 shows another way in which a binary-phase lens may be formed on the bottom surface of the FIG. 2 assembly.
FIG. 1 represents a conventional array of vertical cavity surface-emitting lasers. Illustratively, an X-Y array of spaced-apart lasers is depicted. By way of example, the pitch size of the array is about 100 micrometers (μm). Thus, the center-to-center X-direction distance c of the particular three lasers show in FIG. 1 is 100 μm.
The individual lasers of the array represented in FIG. 1 are identical to each other. As is well known, each such laser comprises an active region sandwiched between mirrors, thereby to form in effect a resonant cavity. Thus, for example, the lefthand laser of FIG. 1 comprises active region 10 (which consists of InGaAs quantum wells separated by GaAs spacers), a highly reflective upper mirror 12 that includes multiple alternating layers of GaAs and AlGaAs which is Be p-doped, and a less highly reflective lower mirror 14 which is similar in composition to the upper mirror except that it is Si n-doped. The lower mirror allows some of the light generated in the laser to be emitted downward in the Z direction.
The conventional FIG. 1 array further includes electrical contacts 16 made, for example, of gold, ion-damaged isolation regions 18 surrounding the lasers, a buffer layer 20 made of n-type GaAs and a GaAs substrate 22 which has high transmissivity at the wavelength emitted by the laser. Each of the indicated lasers provides a Z-direction output beam that is emitted from the bottom X-Y planar surface of the substrate 22. For the lowest transverse-mode laser operation, each such output beam may be approximated as being Gaussian in nature.
The width or waist of each Gaussian beam (measured to 1/e2 of its intensity, where e=2.7182) at the interface between the layer 20 and the substrate 22 of FIG. 1 is Wo. In one particular illustrative example, the waist Wo is 10 μm in a GaAs substrate (n=3.5) for a beam wavelength in free space of 0.98 μm.
Due to diffraction from the output aperture of each resonator, the beam provided by each laser of the FIG. 1 array diverges in the GaAs substrate 22. Thus, a 10-μm-wide Gaussian beam emitted from each resonator at 0.98 μm exhibits a full divergence angle of about one degree in the GaAs substrate 22 (whose index of refraction is 3.5). After exiting from the bottom surface of the substrate 22 and entering air, each beam diverges even more. In air, the full divergence angle of each beam is about four degrees. (For a planar wave emitted from a 10-μm-aperture laser, the full divergence angle in air would be considerably greater, about eleven degrees.)
The aforementioned diffraction phenomenon is illustrated in FIG. 1 wherein dash lines denote the profile of each emitted laser beam. In particular, the dash lines indicate where the intensity of each beam has dropped to 1/e2 the value at the beam center. As a result of this phenomenon, the exiting beams interfere with each other at a relatively short distance downstream of the output face of the array. Such interference causes crosstalk and other deleterious effects. In practical embodiments of laser arrays as heretofore constructed, such interference occurs at a distance d (FIG. 1) from the output face. For example, for a laser array pitch of 100 μm, d is about 1.7 millimeters.
FIG. 2 shows a laser array of the FIG. 1 type modified in accordance with the principles of the present invention. Elements in FIG. 2 that are identical to previously described corresponding ones shown in FIG. 1 are designated in FIG. 2 with the same reference numerals.
In accordance with this invention, individual Fresnel microlenses are fabricated on the bottom planar surface of the substrate 22 in respective alignment with the lasers included in the depicted array. Initially, for illustrative purposes, emphasis will be directed to the design of lenses that serve to focus these output beams. Later below, mention will be made of how to modify this design to achieve collimated output beams.
In accordance with one feature of the invention, symmetrical so-called binary-phase Fresnel lenses 21 are fabricated on the bottom surface of the substrate 22 of FIG. 2 in respective alignment with the aforedescribed lasers. In one embodiment, each such lens comprises a series of concentric circular grooves formed in the bottom surface of the substrate 22. Such grooves are easily formed in conventional ways by standard photolithographic and ion milling techniques.
For purposes of simplification and so as not to unduly clutter the drawing, each of the three identical lenses 21 shown in FIG. 2 is schematically depicted as including only two concentric grooves. To achieve practical diffraction efficiencies, however, each such lens actually includes multiple such grooves (at least about ten). If fewer grooves are utilized, aberrations result accompanied by an increase in focal spot size. Advantageously, the depths of all the grooves are the same.
To focus a Gaussian beam, the groove depth needed in a binary-phase Fresnel lens to achieve a (2i+1) π phase shift, where i equals 0 or any positive integer, is given by the expression ##EQU1## where λ is the wavelength of the output of the associated laser, and n is the index of refraction of the material in which the grooves are formed. For GaAs (n=3.5) and for a λ of 0.98 μm, the depth of each groove in the herein-considered illustrative embodiment is 0.196 μm.
Assume, for example, that it is desired to focus the Gaussian output beams provided by the FIG. 2 assembly at a distance S' in the Z direction from the planar output face of the substrate 22. The waist or width of each of these focused beams at the distance S' is designated W'. The focal length f of the Fresnel lens required to achieve such focusing is obtained from the expression ##EQU2## where λ, Wo, n and S' are as specified above, and S is the Z-direction thickness of the substrate 22. In turn, the new waist size of the focused beam at the distance S' is given by the expression ##EQU3##
By utilizing the design criteria specified above, it is feasible to fabricate an integrated laser-lens assembly of the type shown in FIG. 2 to focus output beams at specified distances from the output face of the assembly. In that way, the output beams can be coupled, for example, to associated optical fibers and detectors in a precisely controlled and efficient manner.
In a specific illustrative example in which Wo =10 μm, λ=0.98 μm, n=3.5, S=300 μm, S'=106 μm and f=108 μm, the new waist size W' of a Gaussian output beam provided by the FIG. 2 assembly is approximately one μm. In practice, such focusing can be achieved with an array of simple identical binary-phase Fresnel microlenses. The structure of one such microlens 25 is represented in FIG. 3.
The binary phase Fresnel microlens 25 shown in FIG. 3 comprises multiple concentric vertically walled grooves constituting zones 26,27 . . . 37 each having the same Z-direction depth. To achieve practical diffraction efficiencies, the microlens of FIG. 3 includes, for example, fifteen such zones. The center point 38 of the symmetrical microlens 25 lies on the longitudinal Z-direction centerline of an associated one of the lasers included in the FIG. 2 array.
In FIG. 3, radial lines indicate the inner and outer bounds of each of the aforementioned zones. Thus, for example, radii R1 and R2 define the location of the vertical Z-direction surfaces that form the walls of the zone 26. Hence, the radii R1 and R2 define the width of the zone 26. Similarly, R3 and R4 define in effect the width of the zone 27, and R23 and R24 define the width of the zone 37.
The length of each of the radial lines R1, R2, R3, R4 . . . R23 and R24 shown in FIG. 3 can be determined from the expression
Rm 2 =mfλ (4)
where m=1,2,3,4 . . . 23,24, and f and λ are as defined earlier above. Thus, for example, for the particular example in which f=108 μm and λ=0.98 μm, R1 2 =(108) (0.98) or R1 =10.3 μm. Similarly, R2 =14.6 μm. Thus, the width of the zone 26 is thereby defined as being 4.3 μm. In the same way, the zone 27 is determined to be radially spaced apart from the zone 26 by 3.2 μm, and the width of the zone 27 is calculated to be 2.8 μm. Further, the width of the outermost zone 37 is 1.1 μm, with the distance R23 being 49.3 μm.
In the aforementioned arrangements, the output of each laser is focused at a new waist location that is symmetrically disposed with respect to the longitudinal centerline of the laser. Such focusing is accomplished with a centrally positioned symmetrical microlens of the type depicted in FIG. 3. Alternatively, in accordance with this invention, it is feasible to utilize microlenses to steer output beams to off-centerline locations. In that way, for example, two or more beams may be directed to a specified location for coupling into the same optical fiber.
FIG. 4 illustrates a portion of a Fresnel microlens suitable for such off-centerline focusing. The depicted microlens 38 includes multiple nested semicircular grooves 40, 41 . . . 51 that are arranged as shown with respect to a point 52 that lies on the longitudinal Z-direction centerline of an associated one of the lasers included in the FIG. 2 assembly. By means of such a microlens, it is possible to focus the output beam of a laser to a downstream location that is not centered with respect to the centerline of the laser. Thus, for example, the FIG. 4 microlens is effective to steer an output beam to a downstream location whose center point is displaced in the X direction from the point 52 by a distance Δ. Such an out-of-plane center point 54 is indicated in FIG. 4.
In accordance with the invention, microlenses that exhibit higher diffraction efficiencies than the simple binary-phase structures described above are feasible. A particular illustrative example of such a more-efficient microlens is represented in FIG. 5. The depicted structure constitutes a so-called multiple-phase microlens. In the multiple-phase structure, each of a series of concentric grooves formed in the substrate 22 of FIG. 2 includes on one side thereof multiple steps rather than a vertical wall as in the binary-phase arrangement. As indicated in FIG. 5, the multiple-phase microlens is, for example, formed in the substrate 22 in symmetrical alignment with respect to the centerline 56 of an associated laser.
Both the binary-phase and multiple-phase Fresnel microlens specified above are described for illustrative purposes as being formed by making grooves in the substrate 22 of FIG. 2. Alternatively, it is feasible to fabricate the microlenses by depositing a layer of material on the bottom surface of the substrate 22 and then patterning the layer in conventional ways to form the required grooves.
An illustrative such alternative structure is depicted in FIG. 6. As indicated there in simplified form, a layer deposited on the bottom surface of the substrate 22 has been patterned to form concentric grooves 56 and 58. By way of example, the patterned layer formed on the GaAs substrate 22 is made of a material such as Si3 N4.
Finally, it is to be understood that the various specific arrangements and techniques described herein are only illustrative of the application of the principle of the present invention. In accordance with these principles, numerous alternatives and modifications may easily be made by those skilled in the art without departing from the spirit and scope of the invention. For example, although primary emphasis herein has been directed to utilizing Fresnel microlenses to focus the output beams from a laser array, it is also feasible to employ such microlenses to collimate the output beams. This is easily achieved by ensuring that the aforespecified distance S' is made smaller than the Rayleigh length b, where b is defined as ##EQU4## and where Wo and λ are as defined earlier above.
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Szechwan Chicken Salad
Combine jicama, the crisp root vegetable from Mexico, with a medley or other fresh vegetables and grilled chicken in this main dish salad recipe.
- Makes:
- 4 servings
- Prep:
- 25 mins
- Marinate:
- 4 hrs
- Grill:
- 12 mins
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Szechwan Chicken Salad
teaspoons cooking oil
teaspoon toasted sesame oil
cloves garlic, minced
tablespoons grated fresh ginger
cup rice vinegar or white wine vinegar
tablespoons reduced-sodium soy sauce
skinless, boneless chicken breast halves (12 ounces total)
fresh jalapeno pepper, seeded and chopped
teaspoon sugar
medium carrot, cut into matchstick strips
cup peeled jicama, cut in matchstick strips
lettuce leaves
medium cucumbers, quartered lengthwise and cut into 1/4-inch slices
1 1/3
cups enoki mushrooms
green onions, sliced
tablespoons chopped unsalted cocktail peanuts
- In a small saucepan heat cooking oil and sesame oil over medium-high heat for 1 minute. Cook and stir garlic and ginger in hot oil for 15 seconds. Remove saucepan from heat; stir in the vinegar, soy sauce, and 3 tablespoons water. Cool completely.
- Rinse chicken; pat dry. Place in a plastic bag set in a shallow dish. Pour half of the soy mixture over the chicken; reserve remaining soy mixture. Close bag. Marinate in the refrigerator for 4 to 24 hours.
- Meanwhile, for dressing, in a small bowl stir together reserved soy mixture, 2 tablespoons water, the jalapeno pepper, and sugar. Cover and chill for 4 to 24 hours.
- Drain chicken, discarding marinade. Grill chicken on the lightly greased rack of an uncovered grill directly over medium coals for 12 to 15 minutes or until chicken is tender and no longer pink, turning once. Cut chicken into bite-size strips. Combine the carrot and jicama. To serve, line 4 salad plates with the lettuce. Top with carrot mixture, cucumbers, chicken, mushrooms, green onions, and peanuts. Stir dressing; drizzle 1 tablespoon dressing over each serving. Makes 4 servings.
Nutrition Facts(Szechwan Chicken Salad)
- Per serving:
- 200 kcal cal.,
- 7 g fat
- (1 g sat. fat,
- 45 mg chol.,
- 231 mg sodium,
- 15 g carb.,
- 3 g fiber,
- 20 g pro.
- Percent Daily Values are based on a 2,000 calorie diet


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Home » Videos » AHF Free Meningitis Vaccines – Today in LA KNBC (NBC) Los Angeles (4/15/13) – Los Angeles Video
Posted on 25 April 2013. Tags: 4/15/13, Angeles, Free, KNBC, Meningitis, Today, Vaccines, video
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Amlexanox, an off-patent asthma drug, reversed obesity, diabetes and fatty liver disease in mice, according to a study published in Nature Medicine. The drug appears to inhibit the IKK(epsilon) and TBK1 genes, which might allow the metabolic system to burn more energy, University of Michigan Life Sciences Institute researcher Alan Saltiel said. Researchers plan to test the drug in clinical trials and are working on optimized formulas.
View Full Article in:Genetic Engineering & Biotechnology News
Published in Brief:


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India Palace Restaurant & Bar
12817 Preston Road, Dallas, TX 75230Map
Preston Valley Shopping Center
+1 972 392 0190
Neighborhood: North Dallas
Cuisine: Indian
Indian Palace Restaurant & Bar offers excellent authentic cuisine, but with a keen eye for the taste buds of the western patrons. If you like delicious Tandoori dishes like chicken, lamb kebab or seafood, look no further. A local favorite since 1985, the restaurant serves a wide variety of curry dishes, Balti specialties and a number of vegetarian selections. The beautiful greenery and soft lighting set the mood for a perfect romantic rendezvous.
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- Open Hours: Monday to Friday from 11:00 AM to 02:30 PM, Monday to Friday from 05:30 PM to 10:00 PM, Saturday to Sunday from 11:30 AM to 03:00 PM, Saturday to Sunday from 05:30 PM to 11:00 PM
- Credit Cards Accepted: visa, mastercard, amex, discover, diners
- Takeout Available: Yes
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Iwa Moto Pregnant
February 4, 2013 | Boy Lopez |
Iwa Moto is said to be eleven weeks pregnant and the father of the child is said to be her current boyfriend Pampi Lacson. It can be remembered that Iwa Moto recently revealed that she is still married to her ex, Mickey Ablan, of which she almost had a child with if only she did not suffer a miscarriage. Iwa Moto is also very vocal of her current relations with boyfriend Pampi Lacson, to the point that she insinuates that Jodi Sta. Maria, Pampi Lacson's ex-wife, was to blame for the breakdown of her marriage with Pampi. Iwa Moto said in interviews that Jodi cheated first on Pampi with her ex-husband Mickey Ablan, even if Jodi knows that she and Mickey were still married. Incidentally, Jodi's current boyfriend Jolo Revilla is running against Jay Lacson, brother of Pampi, for Vice Governor of Cavite Province.


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The Racing Capital
of the World
May 29, 2016
It's the best way to get autographs! Get closer to the drivers by getting access to the Garage Area. For the Month of May ONLY, fans can purchase access to the historic Gasoline Alley, also known as the Garage Area.
You also get month-long access to the IMS Gasoline Alley, where you'll be able to get up close and personal with the drivers and mechanics of the Indianapolis 500 and the Angie's List Grand Prix of Indianapolis. For nearly 100 years, Verizon IndyCar Series teams have relocated their race teams to Gasoline Alley for the month of May. In this area, mechanics tune and repair race cars just inches away from fans. Only credentialed Bronze Badge holders get this level of access.
Remember to get your Bronze Badges quickly, because they are limited. We recommend you order early by mail. Lost or stolen Bronze Badges or coupons cannot be replaced, and there are no refunds.
2015 Bronze Badges for the Angie's List Grand Prix of Indianapolis and 99th running of the Indianapolis 500 mile race are available now. Please visit our purchase page to reserve your Bronze Badge today! Bronze Badge prices will increase to $150 on April 1. Don't wait order today! Purchase Now
For more information, please call the IMS Credential Office at (317) 492-6500.
All Bronze Badge holders have access to a Pre-Race Grid Walk prior to the start of the Angie's List Grand Prix of Indianapolis Sat. May 9.
You must purchase a Race Day ticket to the Angie's List Grand Prix of Indianapolis to gain entrance to the track on Sat. May 9.
* A non-transferable Bronze Badge is issued to the specific individual redeeming the coupon and is usable by that person only. If Bronze Badge(s) are mailed, please confirm that the correct individual receives his/her assigned badge number. Transferring a Bronze Badge among individuals is strictly prohibited.
The Junior Garage Credential provides access to the garage area for the little race fan in your life. Children from ages 9-17 are granted access to get up close and personal with their favorite drivers and teams to make memories that will last a lifetime.
Make sure to get your Junior Garage Credential quickly, as they are limited.
Call (317) 492-6500, or visit the IMS Credential Office located inside the Admin Building just outside of the of roundabout on 16th Street and Crawfordsville Road. Parent or legal guardian AND minor must both be present when picking up the minor credential and each will need to sign the required consent and liability release forms at the time of purchase.
The accompanying parent, legal guardian or adult attending with the minor will be required to show proof of a Bronze Badge purchase or credential when picking up the Junior Credential.
For more information regarding the Junior Garage Credential, please call the IMS Credential Office at (317) 492-6500.
* A non-transferable Junior Garage Credential is issued to the specific individual redeeming the coupon and is usable by that person only. Transferring a Junior Garage Credential among individuals is strictly prohibited.


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Jade Residence combines an ocean view with energy-efficient design
May 1, 2014
New York-based architectural firm E/L Studio recently completed work on an "eco-friendly" beach condo based in Wildwood, New Jersey. Dubbed Jade Residence, the home boasts a great ocean view and energy-efficient technology including passive ventilation and solar power.
Jade Residence measures a total of 306 sq m (3,300 sq ft), spread over two floors. The lower floor is actually split into two rental units, while the main vacation residence is upstairs. In all, the build took a total of two years to complete and during this time E/L Studio installed several features that both save and generate electricity.
During a chat with Gizmag, E/L Studio revealed that Jade Residence features a geothermal heating and cooling system based around deep thermal wells which are buried in the ground, and a solar hot water system that provides all the necessary hot water.
The building is orientated in order to allow the prevailing breeze to pass into the interior, while automatic light monitors ensure constant diffuse natural lighting and also maximize the efficiency of the roof-based solar panels.
The house averages a temperature of roughly 12ºC (55ºF) so requires little additional heating from the on-board mechanical HVAC system, except in severe weather – and should such weather indeed strike, a hurricane-resistant rain screen has also been installed.
Source: E/L Studio
Except for the geo-thermal, there is nothing particularly inspiring or advanced with this house. And an inside temp of 12C is going to require substantial heating to be comfortable.Martin Hone


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After a severe electoral drubbing in the Lok Sabha elections, it was time for the ruling Congress and NCP to fall back on a tested populist formula for the assembly polls — caste and religion based quotas for Marathas and Muslims.
This is for the first time in Maharashtra that reservations will be given on the basis of religion, provoking criticism from opposition parties like the Shiv Sena and the BJP.
The Maharashtra cabinet on Wednesday approved 16% and 5% quotas for Marathas and Muslims respectively. Chief minister Prithviraj Chavan said these reservations will be applicable in the government-run educational institutions and jobs, creating heartburn among other social sections and cries of these decisions being legally unsustainable.
This will take the quantum of reservations in the state to 73% from the earlier 52%, violating the Supreme Court judgment in the Indira Sawhney case, which said reservations were not to exceed 50%. While Maharashtra has a 2% quota for the special backwards category (SBC), it has managed to stay out of legal trouble through some deft manoeuvring.
Muslims form around 10.6 per cent of Maharashtra's population. The decision has raised the hackles of some Muslims who feel upper-caste 'Ashraf' Muslims will walk off with the benefits leaving backwards in the cold. Various Muslim classes fall in categories like other backward classes (OBCs), vimukta jati and nomadic tribes (VJNT), SC/STs.
"There is no space for religious reservations in our Constitution," said BJP spokesperson Madhav Bhandari, pointing to how quotas for Muslims by other states like Andhra Pradesh had been struck down in the past. "The Congress is not respecting the Constitution framed by Dr Babasaheb Ambedkar for the sake of vote bank politics," he charged. However, considering the huge numbers of Marathas, almost all political parties have supported quotas for them.
OBCs and social activists are also upset at the Maratha community being given quotas despite the community dominating the socio-political sphere in Maharashtra, accounting for a majority of elected representatives and chief ministers. Even Maratha community leaders are sceptical on the legal footing of the move. Reducing the open quota would shrink the space for castes like Brahmins and even OBCs who fall in the "creamy layer" and SCs and STs who want to compete from the open category. The state backward classes commission had rejected the proposal to grant reservations to Marathas in 2008.
The state government had appointed a committee headed by state industrial minister Narayan Rane to study the social and economical condition of Marathas in the state, while the Mehmood-ur-Rehman committee had recommended 8-10% reservation for Muslim in education and jobs.
"These are not political reservations. We have given reservation on the basis of backwardness of these both Maratha and Muslim communities. The Rane committee has quantified all these data that will also stand in the court of law. We have taken the decision within the framework of law. Very soon, the GR will be issued and it will come with immediate effect," said Chavan, clarifying that the reservation was not religion-based.
He said they will also take care that giving reservation decision will not be challenged in court. "We are ready to back our decision in court as well. We will not disturb the existing 52% reservation. This reservation issue was in the pipeline for the past 10 years. It was a legitimate demand; therefore we approved it in today's cabinet meeting. It will help to uplift the poor Maratha and Muslim families," said Chavan.
Deputy chief minister Ajit Pawar said they are not worried about their decision being opposed. "We felt there was a need for reservation, so it was given. And, we have fulfilled the promise, which was given in our election manifesto."
"This decision was taken in haste with an eye on the elections," Shabbir Ansari of the All India Muslim OBC Organisation, a veteran of the Muslim OBC movement, said. Upper-caste Muslims would edge out backwards from the community, he said. He added that the Constitution had no provision for reservations on religious and economic grounds, and noted that the best way to ameliorate the condition of Muslims was to strengthen and ease the grant of quota benefits to OBC Muslims who form overwhelming numbers in the community.
OBCs point out that though Maratha-Kunbis were estimated at around 31.5% of Maharashtra's population (based on the 1931 census), Kunbis who have large numbers in areas like Vidarbha and the Konkan are already in the OBC category, leaving out only a small percentage of Marathas outside the reservation net. However, there is confusion over the numbers of the community with a state government publication listing them at just 16%.
Kunbis (agriculturists) and Marathas (warriors), are interchangable terms, with the warrior class being identified with the term 'Maratha' otherwise used to denote people of Maharashtrian origin.
"This is emotional cheating of the Marathas. These reservations are unconstitutional," charged writer and activist Sanjay Sonawani, adding that it would be legally challenged.
Vinayak Mete, MLC and president of Shivsangram welcomed the state government decision. "But I have doubt that it will not stand in the court of law. We worked hard for this day, hope it will last," he said.
"This is the culmination of a 33-year-old demand. This will help social and economic mobility for marginal farmers who were unable to educate themselves due to backwardness," said Pravin Gaikwad of the Sambhaji Brigade.
Currently, apart from 13% and 7% reservations for SCs and STs, the 356 OBC castes get 19% reservations, followed by 11% for 51 VJNT communities and 2% for 11 castes, included in the SBC. OBCs are estimated at over 52% of the population including 43.70% Hindu and 8.40% non-Hindus. Though the quantum of quotas in Tamil Nadu is 69%, this is pre-Mandal and no upper castes like Marathas are covered.


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For those who are passionate about freight cars, it is interesting what may cross one's path.
Click on the image for a larger view
Union Pacific #903719 is a Pullman-Standard 2100 Covered Hopper which was built in May 1959. On March 22, 2011, it descends with train outside of Helper, Utah. The car's right side and A-end haven't escaped the taggers, but the left side is still clean in the silver paint--applied in June of 1984. At fifty two years old, this car may have once been under the command of almost any of Union Pacific's "Classic" diesels--including F3s, F7s, U25Bs and the like. Having outlasted them and most other cars of its era, the 903719 plies onward in company service on former Rio Grande rails.
Click on the image for a larger view
Santa Fe #312426 was painted by Pullman-Standard's Butler, PA. shops on May, 17, 1971. In those 40 years, it survives in original paint and otherwise remarkable condition--with the other side of being just as clean. On March 23, 2011, the car was being reclassified in Provo, Utah. It is difficult to assess how many ATSF PS-2CD 4427s are in service in this condition. My thoughts are that there are very few.
Happy railroading!


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WASHINGTON, US: it is opposite to common wises, however, senior citizens are definitely wiser than young people make supernatural details for complicated occasions within their everyday life, from growing older to passing away, a worldwide study at four key universities from the scholars.
Cristine H Legare, who is a psychologist from the Texas university said about the finding of these forces that science has never superseded the religious beliefs, plus these two things exist together for billions of individuals all around the globe because scientific research can demonstrate numerous things, it "truly isn't really very good" as it is providing answers to a few of the more complicated life's questions.
Cristine H Legare has lead the writers of the research, they moved to South Africa to find out whether individuals there continue to describe their sickness which has troubled the majority of that nation by turning to witchcraft
Based upon the interviews with the three hundred and sixty six contributors who reside in most of the hardest-hit locations, and the responses they observed was yes specifically amongst the mature grownups.
She explains in her interview that it's actually not only due to the fact of ignorance. The individuals shown to be very much informed about the clinical medicine foundations for HIV AIDS, but using more than 40 percentages of the persons in most areas of Southern region of Africa contaminated with this disease, a biomedical clarification is an imperfect solution.
ABC news channel quotes her interview by stating "What started to be obvious is individuals had various kinds of answers to describe various elements of the HIV AIDS,"
She said when interviewing to ABC channel "Unprotected sexual intercourse is noticed as an explanation for being infected with the virus, however that isn't going to demonstrate the more substantial problem of why me, and why not someone else. That is the reason People today would often give an unnatural justification, which includes witchcraft,"
The members in the research were reading through a sequence of statements and expected to refuse or support professional medical or supernatural which is witchcraft details of the disease that is AIDS.
The contributors, regardless of whether youthful or aged, obviously grasped the medical description based on how HIV AIDS is passed on, however, young children from the age of five to fifteen years reported by witchcraft as an element of the clarification only about one half of the time. On the other hand, all the grownups believed witchcraft performed a role.
They concluded the study by saying "Essentially, bewitchment details are not the final result of prejudice of scientific reasons. Therefore, they persisted together with and weren't substituted by scientific answers,".
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Westin Names Brandon Erndt as Managing Principal Engineer
Erndt has experience in SCADA system design, program design, project management & programming
Westin Engineering announced that Brandon Erndt, P.E. has joined the firm as managing principal engineer. Erndt will be responsible for the engineering practice throughout the Western United States, specializing in SCADA master planning, design, system integration,and business development to continue building a greater presence in the industry.
"We are excited to bring Brandon on board with the Westin team. His skillset and experience in the water and wastewater utility industry will reinforce our position in bringing SMART Integrated Business Solutions to the market. Our customers will benefit from his deep knowledge of the industry and affinity toward staying on the leading edge of industry trends and technology," said Doug Harp, president and CEO of Westin.
Erndt, a licensed Professional Engineer, boasts a career that spans over 17 years with extensive experience in SCADA system design, program design, project management and programming. He holds a bachelor's degree in electrical engineering, an MBA in technology management and is a member of several professional associations.
"Brandon will be a valuable addition to our organization. He is a great fit for our team, and he complements and enhances our planning and technology offerings in the water and wastewater arena, helping us maintain and expand our foothold as a leader in the field," said Bill Serjeantson, Westin's vice president of engineering.
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- Cityworks Work Order API Facilitates SCADA Integration at Waterford Township


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Details coming soon! Steve 281-531-9090 or [contact seller] ... More
There were only 11 Eleanor Mustangs built for the 2000 hit film Gone in 60 Seconds, only 3 of those were drivable, and after... More
A collector's item from the moment they were announced, the 2007 Shelby GT500 has always been a desirable coupe. Of course it only... More
You are looking at a beautifully restored 1955 Ford Fairlane 4-Door Sedan. It is a privately owned vehicle being sold on consignment at Stressless... More
Just arrived, a car is the 1950's Ford model on the top of everyone's list. The Club Victoria was the top of the line Fairlane... More
Just arrived, a car that was professionally built about ten years ago by a body shop owner. Amazing custom body panel work. Chrome and badging was... More
Completely redone 1965 Mustang Convertible. Originally a 6 cylinder, this car has been completely and professionally converted to a V8. New Ford Racing 302-340hp... More
This is the 2nd year of production for the T-bird. Automatic transmission, 312, and dealer installed A/C. Power steering, brakes, and windows. Yellow with... More
Bob Reilly at Rosner MotorSports is privileged to offer this incredible piece of American history. Our 1934 Ford "Contractors Special" is powered by its... More
Offered here, is a very clean 1930 Model A Deluxe Rumbleseat Coupe. I am advised this car was completely restored is 2002 including the... More
1962 Ford Thunderbird CoupeThis 1962 Ford Thunderbird is a must have. Light blue body in excellent condition. 2-door hard top. Runs good with 150K... More
1951 Ford F1 PickupCompletely restored and in mint condition!! This would make a great show truck or just cruising. 33500.00 U.S.FUNDSFeatures - 239 V8... More
1963 Ford Thunderbird Rangoon red with Corinthian white on the roofWell taken care of74100 milesAuto transmission390 V8Beautiful classicVehicle is located in Ellicott MD.Qualified buyers... More
1931 Cabriolet If you are interested in this vehicle or have any questions, please contact Dean at 208-989-8005 Rare late 1931 Model 68-C, All original Henry Ford steel... More
1966 Ford Mustang 'K' Code Fastback Northwest Classic Auto Mall advertises this vehicle for the owner. If you are interested in this vehicle or have any... More


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How long can you go without checking email, or glancing at your smartphone? Clifford Nass, a psychology professor at Stanford University, says today's nonstop multitasking actually wastes more time than it saves--and he says there's evidence it may be killing our concentration and creativity too.
Source: NPR
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Inexpensive Home Decor
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Vintage Heirloom Tea Tray
By: Maureen Wilson
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Serve tea in style on a DIY heirloom tea tray from Maureen Wilson made from old photos and a recycled picture frame. This video shows you how to make this wooden tray craft from start to finish so you can turn your own family photos into a quirky coffee table staple.
- Large frame
- Acrylic paints & paint brush
- Ink pad in brown or black
- Mod Podge (glossy)
- Fabric & Felt
- Photos & Stickers
- Hot glue gun, glue dots, & Gorilla Glue
- 2 drawer handles & screws
- Drill & screwdriver
- 2 spoons
- Rubber feet (optional)
- You'll need a large picture frame. I got this one at Walmart for $5. If you're looking for one at a secondhand shop, select a frame that has both the glass and the backing. Choose a wood frame rather than plastic. Make sure the frame has a border that's wide and flat enough to screw on the handles.
- Begin by removing the glass and backing. Dry-brush the frame with a coat of acrylic paint. Don't worry about doing it perfectly, leaving a few areas of bare wood will make the frame look antique.
- While that dries, we can work on the backing. I'm using fabric from a dress my daughter outgrew; I love the raised flocking on the fabric. You can use any fabric you'd like. Lay the fabric over the back piece, then flip it over. Fold the edges up and hot glue in place. Be sure to pull the fabric taut. Don't worry if it looks messy, it will be covered up later.
- Now we'll add another color or two on our frame. When adding these accent colors, paint very sparingly and focus on the raised areas of the frame. This will make it appear as though the accent colors are actually older layers of paint peeking through the first coat.
- You can age your frame further by lightly rubbing an ink pad over the raised areas of the frame. Use an ink pad that's black or brown.
- Finally, we'll seal the paint with a coat of Mod Podge.
- Next we can add the handles. I selected narrow silver handles. Dab the ends of a handle with paint, and press onto the frame. This will leave marks so you can see where to drill. Drill the holes and add the handles. I purchased machine screws that were shorter than the screws that came with my handles, since my frame isn't very thick.
- Now we can decorate the backing. Be aware that the frame will cover the edges of your backing, so leave a border of blank space while working. Decorate the backing as you would a scrapbook page, adhering the photos with glue dots and embellishing with stickers and journaling. I chose Echo Park's "For the Record" line for this project.
- Add the glass and backing to the frame. Cut a square of felt to cover the back. This looks tidy and will prevent any scratching on the table surface. Seal the backing to the wood with hot glue, then glue the felt to the back of the frame. Flip the frame over and trim off any excess felt.
- If you'd like, you can add rubber feet in each of the corners; this will raise the tray off the table a bit and keep it level because the screws on the back might make your tray slightly unbalanced.
- Finally, I'm adding a couple of ornate spoons to my handles. Use an adhesive that can bond metals, such as Gorilla Glue.
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mom2347 0741801
Jun 19, 2012
I like it. Great way to get pictures out of the books and boxes and visible.
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Discover the results of the LG Kompressor FOLLOW ME™ contest
Resume of the contest
Life would be so easy and fun if we could always have, close to us, the things we need when we need them. It will soon be possible to be followed, as you clean the house, by a new vacuum by LG Electronics: the LG Kompressor Follow Me™
Imagine how your daily life could be transformed if the things that make your life easier were always following you, ready to help you whenever you need them.
Show us how it would feel and bring this magic to life!
You can submit videos, animations or storyboards.
Jury's Prize Winners
Selection by LG Kompressor Follow Me
Pudich #1 Prize
- Video
- Animation
- Creative Writing
- Photography
#1 Prize of €10,000 for Are you baby?
LaBaraqueAFilms #2 Prize
- Graphic Design
- Video
- Illustration
- Creative Writing
- Label & Package Design
#2 Prize of €5,000 for LG KOMPRESSOR - FOLLOW ME !
santawen #3 Prize
- Graphic Design
- Video
- Illustration
- Animation
- Creative Writing
- Label & Package Design
#3 Prize of €2,500 for The Right Way
hinkong #4 Prize
- Video
#4 Prize of €2,500 for I want my mommy too!!!!!


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Hugh Hefner has announced this year's June issue of Playboy will be different to any other issue Playboy Enterprises has ever put out. How so? Well, next month's issue will come with 3D glasses and a 3D centerfold to boot.
Hugh recently revealed to the Associated Press that Playboy is hoping to capitalize on the success of Avatar and other 3D movies by jumping on the 3D bandwagon and offering some 3D content of its own. "What would people most like to see in 3-D?" Playboy's founder asked. "Probably a naked lady."
And that's what we'll get. In just a few weeks, you'll be able to look at Hope Dworaczyk in the nip, in three dimensions.
However, this isn't the first time Playboy has tried to show off a pair of C's in 3D. Hugh told the AP that he tried to do something similar in the 50's. "I actually signed a photographer to shoot two nude women in 3D in Chicago," Hugh said. However, the idea was soon scrapped when Hef found out how expensive it would be to include the glasses with the magazine. This time, the cost of the glasses will be footed by HBO. HBO wanted to find a way to promote its show 'True Blood' and including glasses with the show's logo on them seemed like a great way to do that.
Though most Playboy fans will probably be of a different mindset, it seems Hugh isn't exactly sold on 3D technology. A man after my own heart, Hugh tells the AP that when he goes to the cinema, he goes to escape real life and in that instance, "2D is fine with me." For those of you who agree, there'll be plenty of 2D pictures Ms. Dworaczyk in the June issue too. Speaking of Dworaczyk, what does she think of all this? "It's kind of like it says on the rearview mirror," she joked. "Things may appear larger."
Create a new thread in the Digital Cameras forum about this subject
20bogcotton , May 12, 2010 9:09 PMI found it extremely difficult to look away from her eyes to read the article.
"Things may appear larger."
16Anonymous , May 12, 2010 9:16 PMboobs.
bogcottonI found it extremely difficult to look away from her eyes to read the article.
That is only because she is clothed... Then you would say "what eyes" haha
I just read Playboy for the articles
-2fatkid35 , May 12, 2010 9:19 PMthings may apear larger.....in my pants!
14gorehound , May 12, 2010 9:22 PMof course porn will be the real fuel behind 3d not hollywood.
sex sells they say.
13djackson_dba , May 12, 2010 9:28 PMHow do you 3D that much airbrushing?
3mianmian , May 12, 2010 9:38 PMBeside 3D, Playboy better have the most advanced touch technology as well.
1HavoCnMe , May 12, 2010 9:41 PMgorehound +1
You are dead on, The Adult Industry pushed VHS over BetaMAX and Blu-Ray over HD-DVD. Its the simple fact that more movies come out in a year. Seeing how they could shoot a whole porn in days.
0sliem , May 12, 2010 9:46 PMI'll just read this article at home... the pic of her is too big and distracting.
7dman3k , May 12, 2010 9:51 PMJane, you had me at hello!
-3punny_g , May 12, 2010 10:14 PMI wonder if I Will be able to control her with my Joystick...
0Pyroflea , May 12, 2010 10:23 PMHmm, intriguing.
2megamanx00 , May 12, 2010 10:49 PMOh yeeeeeeaaaaaaaaaahhhhhhhhh!!!!!!!!!!!
2Titanius , May 12, 2010 10:55 PMbogcottonI found it extremely difficult to look away from her eyes to read the article.
I agree, they are quite hypnotic.
6IFLATLINEI , May 12, 2010 11:29 PMbogcottonI found it extremely difficult to look away from her eyes to read the article.
What article?
-6v12v12 , May 12, 2010 11:47 PMWTF is this reported on at Toms'? WHO CARES about some skinny, bony chick with 2-3hrs of make up on? I see hotter chicks walking in Manhattan on a daily basis Vs these drugged up, gold-digging sluts.
-2Anonymous , May 12, 2010 11:59 PMI was hoping for old skool scratch n sniff too but this is good!
2ehcastro3 , May 13, 2010 12:35 AM@ v12v12
you see them nekkid too?


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NY auction house debuts with Lafite double magnums, top Burgundyauction house, new york auction, fine wine auction, wally's, wally's auctions, sothebys, lafite, drc, romanee-conti, burgndy, champagne News Wine News http://www.decanter.com/news/wine-news/584433/ny-auction-house-debuts-with-lafite-double-magnums-top-burgundy http://decanter.media.ipcdigital.co.uk/11150/000005d96/9252_orh100000w160/wallys-wine.jpg http://decanter.media.ipcdigital.co.uk/11150/000005d96/e4ec/wallys-wine.jpg
- 2013-10-08T08:50:00+01:00 Tuesday 8 October 2013
To up the glamour factor, Wally's inaugural auction on 13 November will take place at the Whitney Museum of American Art, where bidders will dine in the downstairs café restaurant on food prepared by a 'world class chef', as yet unnamed.
The $3m worth of fine bottles on offer includes hot sellers from Burgundy and Champagne, such as the rare 1982 Dom Perignon Oenotheque and six bottles of 1993 Henri Jayer Cros Parantoux. In July, a six-bottle lot of the same Jayer wine sold at a Sotheby's London sale for more than $57,000.
Other top items among the 600 lots are a collection of 2010 Grands Crus reds from Domaine de la Romanee-Conti in original wooden cases, estimated at $85,000 to $130,000.
Double magnums of Chateau Lafite-Rothschild from the '60s and '70s, as well as California classics like 1974 Heitz Martha's Vineyard, are among the other high-ticket items lurking in the catalogue, which will go live on 21 October, according to Wally's Auctions president and chief executive officer, Michael Jessen.
'New York is the best market to be in right now,' Jessen told decanter.com. Three sales last month were highly successful, especially a White Plains, New York-based Zachys auction at Smith & Wollensky, where eight bottles of 1947 L'Evangile fetched $245,000 versus a top estimate of just $20,000.
'I've noticed, especially over the past year, that New York seems to have a broader buying base that includes emerging markets like Brazil and Mexico that are cut off from Hong Kong,' said Jessen. 'And New York has more and more American buyers bidding.'
The Wally's buyer's premium will be a 'modest' 20%, lower than the average at other New York auction houses.
Wally's Auctions is an arm of West Los Angeles retailer Wally's Wine & Spirits. In June, founder Steve Wallace sold the firm to Guess Jeans co-founders Maurice, Paul, and Armand Marciano, and business partner Christian Navarro.
The group's auction team is plucked from Zachys, where Jessen spent a decade. Many of the wines come from Wally's long-time clients.
Because of New York regulations, the new auction house is partnering with local shop Crush Wines & Spirits.


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Final Fantasy Tactics: The War of the Lions
So i finished this, are the nintendo ones any good?
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after all this time since 1998 i just brought myself to finish this game, awesome story and gameplay, so are the advance 1 and 2 fft games any good or are they cheaply imitations thx btw
Cheap imitation. Stories a lot less deep, supreme lack of anything approaching difficulty, and overall a letdown. They can be fun if you do not take them seriously but definitely a far cry from this one.
That was the greatest post I have ever read on these boards, Effy. I laughed, I cried, I ate a whole gallon of ice cream.
FFTA2 is actually pretty good in it's own right. It's not FFT but it's a who lot better that FFTA.
"North Dakota doesn't exist, much like Sonic restaurants. I hear people talking about them but I've never seen any."
-- sfcalimari
Tactics Advanced was certainly charming, but it's not connected to Ivalice at all. The premise is that it takes place in a storybook. If that gives you an idea of how tonally different it is from War of the Lions.
I'm in yer Guild Hall, drinkin yer beers.
People given them undue crap IMO.
They aren't a cheap imitation, if they were I think people would have been happier with them. They don't have the dark story or the convoluted gameplay mechanics this game have so people don't like them.
What do you think it means when a girl leaves a fake mustache at your house?
They're side-quest games. I hate those sorts of games, which is why I passed on both of them.
The Law/Judges systems in the FFTA games aren't very good. I actually really like the idea, but the way they're implemented is rather dumb and unfair.
Please change your vector and move to a different coordinate because this quadrant is off limits.
They're different. There's a little more freedom in them, but along with that freedom comes a little bit of frustration. I would definitely recommend at least starting the first one (the GBA game) to see what you think.
What troubled sleep have you known, to speak of my dreams? No matter how sweet, a dream left unrealized must fade into day - Wiegraf, FFT:tWotL
BlueReckoning posted...
FFTA2 is actually pretty good in it's own right. It's not FFT but it's a who lot better that FFTA.
This is what I have heard also. I bought FFTA2 on a whim after I bought the PSP version of the original. I haven't played the game though but I did beat FFTA on gameboy and i thought it was acceptable (I love FFT though so I overlooked ALL that was wrong w/ FFTA). But I heard and thus bought FFTA2. So I'd say get it. Also try Suikoden Tierkeris if you can get it. It's not bad either.
All time favs: FFX Int., FFXIII, Shadow Heart Series, SMT: Nocturne, SMT DS(3DS), ToS, ToGF, TotA, FFT, Xenogears, Chrono Trigger, ARF (Wii), LO (360), TO (PSP)
I started the Tactics games with FFTA, and I love them. While the original Tactics and War of the Lions both have much deeper stories and much higher difficulty, I found both FFTA and FFTA2 to be well worth playing. The problem with FFTA is the law system. It starts off as a neat restriction system that is fairly well balanced, but by the end of the game it's completely unfair and hinders a lot of units. FFTA2 kind of corrected this, but the game is still much less dark and dramatic. One of the good things about them though is that they have a little postgame to them. War of the Lions had very little post game (basically just Midnight's Deep). If you enjoyed the gameplay of FFT, then you should definitely check FFTA and FFTA2 out.
White FC: 4727 7422 4019
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Pampanga activists protest against China 'bullying'
More News from Tonette Orejas
CITY OF SAN FERNANDO, Pampanga—On behalf of her father, who has been fishing at Scarborough Shoal west of their Masinloc home in Zambales, Ruelyn Gubalane on Friday joined some 200 activists protesting China's "bullying" of the Philippines amid a territorial dispute.
The multi-sectoral group Stand Up for Scarborough Shoal (Stand Up!) organized the protest in front of the Paskuhan Village here. At the rotunda across two malls and leading to the North Luzon Expressway, the protesters planted 50 placards condemning China.
Some read: "China, Bully. Get out of our Sea," "China: Afraid of Itlos [International tribunal for the Law of the Sea]," "Make peace, not war;" and "Huangyan? Huwag yan (Not that)! Scarborough is our Shoal."
Gubalani's father, Ruel, 44, was originally from Leyte but he settled in Barangay (village) Inhobol in Masinloc where many fishermen regularly catch fish during off-rainy season. He works as the captain of a vessel that fishes for tuna at the shoal, which locals call Bajo de Masinloc.
"Bata pa 'ko, nangingisda na sa Scarborough ang tatay ko. Yung mga matatanda namin sa baryo, dun din nangisda. Sa Pilipinas talaga ang Scarborough (My father has been fishing at the Scarborough Shoal since I was young. Old folks in our village say that was where they also fished. Scarborough Shoal really belongs to the Philippines)," said Gubalani, 25, a staff member of the Pampanga-based Center for Emergency Aid and Rehabilitation (Concern), which trains communities in disaster preparedness.
The shoal is within the 320-kilometers exclusive Philippine economic zone. Facing Zambales, it is 220 kilometers from the province, 320 km from Puerto Princesa City and 350 km from Manila.
"Let it be clear to all that the Filipino people have no quarrel with their Chinese brothers and sisters, with whom they share centuries of good relations. Many Filipinos of Chinese descent have helped build, and continue to build, our nation," Stand Up! said in a manifesto.
"Our protest is directed at the overbearing actions and stance of the government in Beijing, which behaves like an arrogant overlord, even in the homes of its neighbors."
Kelvin Vistan, spokesman of the Kilusan para sa Pambansang Demokrasya in Pampanga, blamed the United States for "provoking the conflict."
"This is part of the current strategy of the US to control the Asia-Pacific and stop the growth of China," Vistan told reporters.
Jerome Gatchalian said he and his fraternity brothers in Phi Beta Rho Banahaw chapter joined the protest because "we are Filipinos."
Merly Gomez, a paralytic, said she joined the protest to "assert Philippine territory." "Hindi yun puwedeng agawin dahil para sa Filipino ang Scarborough (China can't take it from us because Scarborough is for Filipinos)," Gomez said.
Former Pampanga Governor Eddie Panlilio said, "This is a time of reasons and laws but China refused to go to the [International Tribunal for the Law of the Sea]."
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