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The endothelial nitric oxide synthase gene (NOS3) has been proposed as a candidate gene for preeclampsia. However, studies so far have produced conflicting results. This study examines the specific role of variants and haplotypes of the NOS3 gene in a population of Caucasian origin.
We examined the association of three common variants of the NOS3 gene (4b/a, T-786C and G894T) and their haplotypes in a case-control sample of 102 patients with preeclampsia and 176 women with a history of uncomplicated pregnancies. Genotyping for the NOS3 variants was performed and odds ratios and 95% confidence intervals were obtained to evaluate the association between NOS3 polymorphisms and preeclampsia.
The single locus analysis for the three variants using various genetic models and a model-free approach revealed no significant association in relation to clinical status. The analysis of haplotypes also showed lack of significant association.
Given the limitations of the candidate-gene approach in investigating complex traits, the evidence of our study does not support the major contributory role of these common NOS3 variants in preeclampsia. Future larger studies may help in elucidating the genetics of preeclampsia further.
Preeclampsia is a medical condition in which high blood pressure and elevated urinary excretion of protein develop in pregnancy [1]. Family-based studies have shown that genetic factors may play a role in preeclampsia [2]. In addition, candidate-gene association studies (GAS) on preeclampsia have not produced conclusive results so far [3]. However, the pathogenesis of preeclampsia is poorly understood and the search for low-penetrance genes by hypothesis-driven candidate-gene studies (genetic association study-GAS) and hypothesis-free genome-wide association studies is ongoing [4].
The leading hypotheses, concerning the pathogenesis of preeclampsia, are based on disturbed placental function and impaired remodelling of the spiral arteries [5]. Endothelial nitric oxide synthase (NOS3) is an important regulator of vascular tone and contributes to the reduction of the uteroplacental resistance seen in normal pregnancy [6-8]. Therefore, the endothelial nitric oxide synthase gene (NOS3), located at the 7q35-q36 region, has emerged as a logical candidate gene in the development of preeclampsia. Variants (polymorphisms) of the NOS3 gene have been investigated for association with preeclampsia and other disorders such as hypertension [9,10]. The three most common variants examined for clinical relevance, based on their potential functional effects are [11]: (i) a G894T substitution in exon 7 resulting in a Glu to Asp substitution at codon 298 (rs1799983), (ii) an insertion-deletion in intron 4 (4a/b) consisting of two alleles (the a*-deletion which has four tandem 27-bp repeats and the b*-insertion having five repeats), and (iii) a T786C substitution in the promoter region (rs2070744). A whole genome-scan meta-analysis for preeclampsia has already identified the locus of NOS3 gene as a promising candidate for preeclampsia susceptibility [2], although linkage studies seem to support a relationship between NOS3 and hypertension rather than preeclampsia [12,13].
Previous GAS that investigated the association between NOS3 variants and preeclampsia have produced controversial or inconclusive results and the replication record of these studies is relatively poor [14,15]. Therefore, the status of association for the NOS3 variants remains ambiguous. In this project we aimed to replicate previous findings on the association between the three most commonly investigated NOS3 polymorphisms (4b/a, T-786C and G894T) and preeclampsia, in a GAS conducted on a homogeneous population of Caucasian origin (Greeks). These variants were chosen because of their potential functional implications and their high minor allele frequency [16-18]. An analysis of haplotypes was also performed [19].
Study population
A total of 102 cases with preeclampsia and 176 female controls were recruited from the Department of Obstetrics and Gynecology, University Hospital of Larissa. Preeclampsia was defined as new hypertension (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg) and substantial proteinuria (>300 mg in 24 h) at or after 20 weeks' gestation [20]. The study protocol was approved by the Institute Ethics Committee and all subjects provided a written informed consent. All controls faced pregnancies without complications and they were free of preeclampsia history. The controls were unrelated by blood to cases, and all apart from 3 (1.7%) were delivered at term. All study participants were of Caucasian origin whereas women with previous renal disease, diabetes, or history of metabolic disorders were excluded from the patient sample. A blood sample for biochemical measurements and DNA extraction was taken from each individual.
Laboratory assays
Genomic DNA was extracted from whole blood using the QIAamp DNA blood kit (QIAGEN, Valencia, CA, USA) following the manufacturer's instruction. Genotyping of each polymorphism was performed by amplification from 50 to 100 ng of genomic DNA. The primer sequences used and the laboratory conditions for genotyping (polymerase chain reaction, restriction enzymes, agarose electrophoresis) for each NOS3 polymorphism have been previously described [16-18]. Genotyping was performed by laboratory personnel blinded to clinical status.
Data Analysis
Continues variables were compared using the Mann-Whitney non-parametric test. Categorical variables were compared using the Chi-square test. The genotypic distribution in the control group was tested for departing from the Hardy-Weinberg Equilibrium (HWE) and the existence of linkage disequilibrium (LD) between the two polymorphisms in both cases and control was tested by using exact tests according to Weir [21]. The haplotype frequencies were estimated and compared using SHEsis [22]. The association between genotype distribution and clinical status was tested using the chi-square test. The dominant and recessive models of the cases was compared to the control group using a logistic model. The significance of the genetic models was also tested using the Fisher's exact test. The comparisons associations were expressed in terms of odds ratio (OR), unadjusted and adjusted for age, with the corresponding 95% confidence interval (CI). The statistical analysis was performed using SPSS v11.5 (SPSS Inc.). A result was considered statistically significant when P < 0.05.
A total of 102 cases and 176 controls were analyzed. The mean age (±SD) was 30.64 ± 6.32 and 29.60 ± 5.18 for cases and controls respectively; all subjects were females. The clinical characteristics of the enrolled subjects are shown in Table 1. The distributions of the NOS3 4b/a, T-786C and G894T genotypes were not associated with clinical status and are presented in Table 2. The generalized ORs for 4b/a, T-786C and G894T polymorphisms were ORG = 0.79 (0.48-1.29), ORG = 0.93 (0.61-1.43) and ORG = 0.86 (0.56-1.32), respectively. The genotype distribution in controls was in HWE for all polymorphisms, indicating lack of stratification and/or genotyping error (p = 0.99 for 4b/a, p = 0.99 for T-786C and p = 0.090 for G894T).
Table 1. Characteristics of the study subjects.
Table 2. Distribution (%) of the NOS3 4b/a, T-786C and G894T genotypes among cases and control subjects.
Table 3 shows the association results for the allele contrast, the recessive and dominant models for the mutant alleles. None of the polymorphism showed significant association with development of preeclampsia for allele contrast, the recessive and dominant models. The unadjusted ORs for the allele contrast were OR = 0.78 (0.50-1.21) for 4b/a, OR = 0.94 (0.66-1.34) for T-786C and OR = 0.91 (0.65-1.30) for G894T. The age-adjusted ORs produced similar results.
Table 3. Association results.
The LD results are shown id Table 4. In both the patient and control populations, the 4b/a and T-786C polymorphisms were in LD (p = 0.02 and p < 0.01, respectively). In addition, the T-786C and G894T polymorphisms were in LD (p < 0.01 for both cases and controls). The distribution of the estimated haplotype distribution of the two NOS3 polymorphisms for cases and controls is presented in Table 5. The estimated haplotype frequencies were similar in cases and controls. The global test of association was not significant for the comparison of haplotypes between cases and controls (p = 0.71).
This study evaluated relations between common genetic variants and haplotypes in the NOS3 gene with preeclampsia. The single locus analysis among the three most commonly studied polymorphisms (4b/a, T-786C and G894T) revealed lack of association. The analysis of haplotypes also showed non-significant association.
The conclusion reached in the GAS was based on relatively small number of participants for each gene polymorphism and therefore, any inferences have to be cautious. Candidate-gene studies have a tendency to lack the power to detect weak genetic contributions of common variants [19,23]. For example, in order to achieve a power >80% to identify a modest genetic effect (odds ratio 1.2) of a polymorphism present in 10% of individuals, a sample size of 10,000 subjects or more would be needed [23]. Therefore, the sample sizes required to predict association have to be far beyond what is currently available and no single institution or entity alone will be able to provide a reasonable number of patients. Meta-analysis of multiple studies has clearly a role in offering an analysis with the potential for enhanced power [19].
It has been reported that the polymorphisms might be in linkage disequilibrium and interaction of the polymorphisms within haplotypes can be a major determinant of disease susceptibility than the individual polymorphism [11]. Thus, individual NOS3 genotypes might not be reliable markers of risk for developing preeclampsia. The haplotype analysis approach is expected to be more powerful than single-marker analysis, because of the ancestral structure incarcerated in the distribution of haplotypes [10]. Particularly if the markers used define mutations within functional DNA, then the haplotypes composed of these markers can have more of a biological role. In our analysis, we focused on haplotypes defined by the three most commonly investigated and potentially functional NOS3 variants (instead of other tested variants or HapMap tagging polymorphisms) because we aimed to replicate the already examined associations [9,24,25].
Interestingly, 13 studies [9,24-35] have reported positive association for the variants NOS3 gene, whereas the two published meta-analyses and other individual studies did not replicate the findings [14,15,36,37]. Thus, the available evidence from candidate-gene approach cannot support a major contributory role of NOS3 variants in preeclampsia pathogenesis. Since predicting the functional credentials of most genetic variants remains problematic, obtaining robust replication of positive association findings proves difficult [38]. Moreover, the multifactorial etiology of common disorders involving complex epistatic and gene-environment interactions reduces the likelihood that a single type of studies, such as gene-candidate association studies, could provide conclusive inferences. An integration approach combining different kinds of genetic data analysis (i.e. genomic convergence of GAS, GWAS, genome-scans and microarrays) may be more effective in identifying valid genetic loci [39,40].
In conclusion, the genetic association study did not replicate a significant association for the NOS3 variants and haplotypes. The results of the present individual GAS should be interpreted with caution since the number of participants were relatively small. However, preeclampsia is a complex disease with multifactorial etiology and therefore, a minor contributory pathogenetic role of NOS3 variants in conjunction with other genetic or environmental factors cannot be excluded [41]. Collaborative research in preeclampsia may help in identifying the contributing role of variants by performing GAS and genome-wide association studies with adequate power [42]. Furthermore, the design of rigorous studies for investigating epistatic and gene-environment interactions and the utilization of data generated by genomic studies may help in deriving more conclusive claims about the genetics of preeclampsia.
The single locus analysis and the analysis of haplotypes failed to demonstrate a significant association between preeclampsia and three common NOS3 polymorphisms.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
NZ and CD carried out the samples processing and the molecular genetic studies. NZ was involved in data acquisition, analysis and interpretation, and helped in the preparation of the manuscript. IEM participated in the design and coordination of the study and reviewed the manuscript. IS was involved in the design and coordination of the study. EZ conceived of the study, participated in its design, performed the statistical analysis and drafted the manuscript. All authors read and approved the final manuscript.
This work was supported by the University of Thessaly in Greece. The authors wish to thank all the women who consented to be involved in the study.
Lain KY, Roberts JM: Contemporary concepts of the pathogenesis and management of preeclampsia.
JAMA 2002, 287:3183-3186. PubMed Abstract | Publisher Full Text
Zintzaras E, Kitsios G, Harrison GA, Laivuori H, Kivinen K, Kere J, Messinis I, Stefanidis I, Ioannidis JP: Heterogeneity-based genome search meta-analysis for preeclampsia.
Hum Genet 2006, 120:360-370. PubMed Abstract | Publisher Full Text
Ward K: Genetic factors in common obstetric disorders.
Clin Obstet Gynecol 2008, 51:74-83. PubMed Abstract | Publisher Full Text
Roten LT, Johnson MP, Forsmo S, Fitzpatrick E, Dyer TD, Brennecke SP, Blangero J, Moses EK, Austgulen R: Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study).
Eur J Hum Genet 2009, 17:250-257. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R: Pre-eclampsia.
Lancet 2010, 376:631-644. PubMed Abstract | Publisher Full Text
Norris LA, Higgins JR, Darling MR, Walshe JJ, Bonnar J: Nitric oxide in the uteroplacental, fetoplacental, and peripheral circulations in preeclampsia.
Obstet Gynecol 1999, 93:958-963. PubMed Abstract | Publisher Full Text
Sladek SM, Magness RR, Conrad KP: Nitric oxide and pregnancy.
Am J Physiol 1997, 272:R441-463. PubMed Abstract | Publisher Full Text
Magness RR, Shaw CE, Phernetton TM, Zheng J, Bird IM: Endothelial vasodilator production by uterine and systemic arteries. II. Pregnancy effects on NO synthase expression.
Am J Physiol 1997, 272:H1730-1740. PubMed Abstract | Publisher Full Text
Serrano NC, Casas JP, Diaz LA, Paez C, Mesa CM, Cifuentes R, Monterrosa A, Bautista A, Hawe E, Hingorani AD, et al.: Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study.
Hypertension 2004, 44:702-707. PubMed Abstract | Publisher Full Text
Zintzaras E, Kitsios G, Stefanidis I: Response to Endothelial Nitric Oxide Synthase Polymorphisms and Susceptibility to Hypertension: Genotype Versus Haplotype Analysis.
Zintzaras E, Kitsios G, Stefanidis I: Endothelial NO synthase gene polymorphisms and hypertension: a meta-analysis.
Hypertension 2006, 48:700-710. PubMed Abstract | Publisher Full Text
Arngrimsson R, Hayward C, Nadaud S, Baldursdottir A, Walker JJ, Liston WA, Bjarnadottir RI, Brock DJ, Geirsson RT, Connor JM, Soubrier F: Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region.
Am J Hum Genet 1997, 61:354-362. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Mitchell GF, DeStefano AL, Larson MG, Benjamin EJ, Chen MH, Vasan RS, Vita JA, Levy D: Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: the Framingham Heart Study.
Circulation 2005, 112:194-199. PubMed Abstract | Publisher Full Text
Yu CK, Casas JP, Savvidou MD, Sahemey MK, Nicolaides KH, Hingorani AD: Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis.
BMC Pregnancy Childbirth 2006, 6:7. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Medica I, Kastrin A, Peterlin B: Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis.
Eur J Obstet Gynecol Reprod Biol 2007, 131:115-126. PubMed Abstract | Publisher Full Text
Tesauro M, Thompson WC, Rogliani P, Qi L, Chaudhary PP, Moss J: Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298.
Proc Natl Acad Sci USA 2000, 97:2832-2835. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Tsukada T, Yokoyama K, Arai T, Takemoto F, Hara S, Yamada A, Kawaguchi Y, Hosoya T, Igari J: Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans.
Biochem Biophys Res Commun 1998, 245:190-193. PubMed Abstract | Publisher Full Text
Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, Motoyama T, Saito Y, Ogawa Y, Miyamoto Y, Nakao K: T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.
Circulation 1999, 99:2864-2870. PubMed Abstract | Publisher Full Text
Zintzaras E, Lau J: Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches.
J Clin Epidemiol 2008, 61:634-645. PubMed Abstract | Publisher Full Text
Sibai B, Dekker G, Kupferminc M: Pre-eclampsia.
Lancet 2005, 365:785-799. PubMed Abstract | Publisher Full Text
Weir B: Genetic data analysis II: methods for discrete population genetic data. Sunderland MA: Sinauer Associates; 1996.
Shi YY, He L: SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci.
Cell Res 2005, 15:97-98. PubMed Abstract | Publisher Full Text
Zintzaras E, Lau J: Trends in meta-analysis of genetic association studies.
J Hum Genet 2008, 53:1-9. PubMed Abstract | Publisher Full Text
Bashford MT, Hefler LA, Vertrees TW, Roa BB, Gregg AR: Angiotensinogen and endothelial nitric oxide synthase gene polymorphisms among Hispanic patients with preeclampsia.
Am J Obstet Gynecol 2001, 184:1345-1350.
discussion 1350-1341PubMed Abstract | Publisher Full Text
Chen LK, Huang CH, Yeh HM, Lee CN, Shyu MK, Hsieh FJ, Lai LP, Sun WZ: Polymorphisms in the endothelial nitric oxide synthase gene may be protective against preeclampsia in a Chinese population.
Reprod Sci 2007, 14:175-181. PubMed Abstract | Publisher Full Text
Fatini C, Sticchi E, Gensini F, Genuardi M, Tondi F, Gensini GF, Riviello C, Parretti E, Mello G, Abbate R: Endothelial nitric oxide synthase gene influences the risk of pre-eclampsia, the recurrence of negative pregnancy events, and the maternal-fetal flow.
J Hypertens 2006, 24:1823-1829. PubMed Abstract | Publisher Full Text
Sandrim VC, Palei AC, Cavalli RC, Araujo FM, Ramos ES, Duarte G, Tanus-Santos JE: eNOS haplotypes associated with gestational hypertension or preeclampsia.
Pharmacogenomics 2008, 9:1467-1473. PubMed Abstract | Publisher Full Text
Sandrim VC, Palei AC, Sertorio JT, Cavalli RC, Duarte G, Tanus-Santos JE: Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia.
Mol Hum Reprod 2010, 16:506-510. PubMed Abstract | Publisher Full Text
Seremak-Mrozikiewicz A, Drews K, Mrozikiewicz PM: The -786T/C polymorphism of the endothelial nitric oxide synthase gene in preeclampsia.
Eur J Obstet Gynecol Reprod Biol 2008, 138:118-119. PubMed Abstract | Publisher Full Text
Seremak-Mrozikiewicz A, Drews K, Barlik M, Sieroszewski P, Grzeskowiak E, Mrozikiewicz P: The significance of -786T > C polymorphism of endothelial NO synthase (eNOS) gene in severe preeclampsia.
J Matern Fetal Neonatal Med 2011, 24:432-436. PubMed Abstract | Publisher Full Text
Sharma D, Singh A, Trivedi SS, Bhattacharjee J: Intergenotypic variation of nitric oxide and inflammatory markers in preeclampsia: A pilot study in a North Indian population.
Sharma D, Trivedi SS, Bhattacharjee J: Oxidative stress and eNOS (Glu298Asp) gene polymorphism in preeclampsia in Indian population.
Tempfer CB, Dorman K, Deter RL, O'Brien WE, Gregg AR: An endothelial nitric oxide synthase gene polymorphism is associated with preeclampsia.
Hypertens Pregnancy 2001, 20:107-118. PubMed Abstract | Publisher Full Text
Yoshimura T, Yoshimura M, Tabata A, Shimasaki Y, Nakayama M, Miyamoto Y, Saito Y, Nakao K, Yasue H, Okamura H: Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia.
J Soc Gynecol Investig 2000, 7:238-241. PubMed Abstract | Publisher Full Text
Aggarwal PK, Jain V, Jha V: Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy.
Hypertens Res 2010, 33:473-477. PubMed Abstract | Publisher Full Text
Hillermann R, Carelse K, Gebhardt GS: The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia.
J Hum Genet 2005, 50:415-419. PubMed Abstract | Publisher Full Text
Tempfer CB, Jirecek S, Riener EK, Zeisler H, Denschlag D, Hefler L, Husslein PW: Polymorphisms of thrombophilic and vasoactive genes and severe preeclampsia: a pilot study.
J Soc Gynecol Investig 2004, 11:227-231. PubMed Abstract | Publisher Full Text
Hattersley AT, McCarthy MI: What makes a good genetic association study?
Lancet 2005, 366:1315-1323. PubMed Abstract | Publisher Full Text
Kitsios GD, Zintzaras E: Genome-wide association studies: hypothesis-"free" or "engaged"?
Transl Res 2009, 154:161-164. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Kitsios GD, Zintzaras E: Genomic convergence of genome-wide investigations for complex traits.
Ann Hum Genet 2009, 73:514-519. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Clayton D, McKeigue PM: Epidemiological methods for studying genes and environmental factors in complex diseases.
Lancet 2001, 358:1356-1360. PubMed Abstract | Publisher Full Text
Pearson TA, Manolio TA: How to interpret a genome-wide association study.
JAMA 2008, 299:1335-1344. PubMed Abstract | Publisher Full Text
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Hot Chocolate Month Starts Tomorrow at City Bakery
Stephbond/Flickr When it's cold outside, go for some warm cocoa.
Chocoholics, rejoice: The happiest time of the year is almost here! Sure, February might be a crap time of year for some people, namely those with seasonal affective disorder and all single people around the 14th, but for cocoa lovers, it means the return of City Bakery's Hot Chocolate Month.
Throughout this February (which has an extra bonus day of hot chocolate since it's Leap Year, woot woot), the Union Square area bakery will be offering patrons a bounty of exotic flavors in addition to its signature hot chocolate. Look for options ranging from ginger hot chocolate (February 3) to Vietnamese cinnamon hot chocolate (February 8) to bourbon hot chocolate (February 10) to the intriguing-sounding ode-to-the-polar-bear hot chocolate, a buttery white cocoa confection (February 22). This year also marks the 20th year of celebrations, meaning there's bound to be a whole lotta chocolate joy. Hope you're not taking that New Year's resolution to diet too seriously.
For more dining news, head to Fork in the Road, or follow us @ForkintheRoadVV, or me @ldshockey.
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A sinkhole that swallowed part of a house and a man in his bedroom in Seffner, Fla., could be uncovered later today. Likely caused by acidic rainwater dissolving the limestone in the earth beneath the house, located in an area called "Sinkhole Alley," the sinkhole is not "typical," said Hillsborough County administrator Mike Merrill. "This is a chasm." Between 2006 and 2010, Florida had 24,671 claims for sinkhole damage.
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Two people were killed in two separate shootings that were less than two miles apart Friday night and early Saturday in Minneapolis.
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LOS ANGELES, CA - NOVEMBER 07: Drew Doughty #8 of the Los Angeles Kings plays the puck around the net during the NHL game against the Nashville Predators at the Staples Center on November 7, 2009 in Los Angeles, California. The Predators defeated the Kings 3-1. (Photo by Victor Decolongon/Getty Images)
GLENDALE, Ariz. -- It took a little longer than initially hoped, but Drew Doughty is ready to play. Doughty, out of the lineup since Oct. 15 because of an upper-body injury, is expected to be removed from the injured-reserve list and be i...
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Maple Park Basketball
The Maple Park Winter Youth Basketball Program for boys grades three through eight runs from mid-January through mid-March, with games on Saturday.
Registration is open and ends Saturday, Nov.14. Forms will be available at Casey's General Store and the Maple Park Library.
For more information on sign-up, call Scott Willis at (630) 621-0736.


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+Vote List
by Michael Gibson * Ranker
Staff tags 223 votes 59 voters ' 30,376 views 13 items
Staff tags 223 votes 59 voters ' 30,376 views 13 items
The Most Important Supreme Court Cases
Quick: Can you name the most important Supreme Court cases in U.S. history? Yes? Well, can you explain them, in a nutshell, to anyone who asks? Impress your friends with your legal history knowledge by perusing this list of some of the biggest, most influential, far-reaching cases ever decided by the Supreme Court of the United States. Didn't see what you think is the most important case? Let us know in the comments!
Rank Name
- Tip: Navigate with your { left and right } arrow keys1+ 23- 1This landmark case in 1803 established the United States' system of judicial review and directly contributed to the government's system of checks and balances of power. The Supreme Court addressed a legal fight involving William Marbury, who was picked (last minute) by outgoing President John Adams to become a District of Columbia justice of the peace. When Thomas Jefferson became the next president, he ordered his Secretary of State, James Madison, not to commission him. The high Court ruled that they really didn't have a say in this matter - but the case pointed out some very, very big loopholes in the system. As a result, the Supreme Court established so-called "judicial review" - offering the opportunity to revisit existing laws to see if they needed to be reworked.
l< << PREV 1 of 13 NEXT >>


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Resolution: standard / high
Figure 1.
The structure of the HMM mixture. The structure of the HMM mixture is shown on the left. Each sub-HMM has the structure shown in the middle. The shaded box is the basic block of the sub-HMM and is repeated length-2 times. It is identical in all sub-HMMs; only the emission distribution of the match state varies between blocks. The emission is either the nucleotide in that position of the HERV sequence or a mismatch. The probabilities for match and mismatch are equal for all blocks. The EEMIT-state emits the low-quality end part.
Oja et al. BMC Bioinformatics 2007 8(Suppl 2):S11 doi:10.1186/1471-2105-8-S2-S11


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Solar Thermal Heating Could Eliminate CO2 Emissions from Cement Production
Cement production is the second largest human-caused contribution of CO2 to the atmosphere responsible for five to six percent of all human-caused CO2 emissions. So far, many researchers have concentrated on creating cement that can sequester CO2 to balance out the CO2 its production releases, but now researchers at George Washington University are going to the root of the problem and eliminating CO2 emissions at the source.
The researchers have found a way to use solar thermal heating to create a method of cement production that has zero CO2 emissions. The release of CO2 during cement production is in two key places: first is when limestone is converted into lime, which involves decarbonation and releases CO2 as a byproduct; second is from burning fossil fuels to heat the kiln reactors that allow that chemical reaction to occur.
The team's Solar Thermal Electrochemical Production (STEP) process eliminates CO2 from both of those places. Solar thermal heating replaces the burning of fossil fuels and the heat also is essential in the electrolysis of the limestone. Using electrolysis to convert limestone into lime creates a byproduct of either oxygen and graphite or carbon monoxide, not CO2.
The STEP process would also be cheaper than the existing cement production process and if the carbon monoxide byproduct were sold to other industries, it would actually create a net positive of $298 per ton compared to the cost of $70 per ton for conventional production.
The researcher say the STEP process could be utilized in other industries that require limestone being converted to lime, like iron and aluminum purification, glass, paper and sugar production and agriculture.
via Phys.org


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Arsenal - Panzerschreck
Ammo Pouch
"Provides a carrying pouch designed for the weapon's ammunition, keeping it ready at hand and allowing you to carry significantly more."
High Explosives
"Upgrades the warhead carried by the weapon's rockets with a more powerful explosive, increasing blast radius and damage."
Light Weight Build
"Refits the weapon with exhaust systems that eliminate the need for the cumbersome blast shield, improving sighting and movement."
"Replaces the weapon's standard open breach with a three round magazine and feed mechanism to facilitate rapid firing."
Seeker Crystal
"Combines a veil infused crystal in each rocket with a special sighting mechanism to allow rockets to lock on to targets and seek them out."
Stabilized Rockets
"Improves the aerodynamic features of the weapon's rockets, greatly improving accuracy, and thereby increasing effective range."
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TimeSeriesAnalysis[BoxCoxTransform] - Box-Cox transformation
TimeSeriesAnalysis[LogTransform] - Log transformation
Calling Sequence
Apply(BoxCoxTransform, timeseries)
Apply(BoxCoxTransform(lambda = lm, base = b, geometricmean = g, shift = s), timeseries)
Apply(LogTransform, timeseries)
Apply(LogTransform(base = b, geometricmean = g, shift = s), timeseries)
Unapply(BoxCoxTransform, forecast)
Unapply(BoxCoxTransform(lambda = lm, base = b, geometricmean = g, shift = s), forecast)
Unapply(LogTransform, forecast)
Unapply(LogTransform(base = b, geometricmean = g, shift = s), forecast)
TimeSeries data set
TimeSeries data set, typically obtained from a forecasting method
(optional) parameter of the Box-Cox transform, typically between and
(optional) if lm is , the base of the logarithm
(optional) true or false, indicating whether or not to correct the scale of the results using the geometric mean
(optional) constant shift applied before the Box-Cox transform is applied
The Box-Cox transformation takes a time series and replaces each value with the value . If the parameter is set to , the resulting value is .
Apply this transformation to a time series using the Apply command. Translate transformed information, such as a forecast from transformed data, back to the original domain by using the Unapply command.
By default, the parameter has value , and the transformation is the log transformation (the natural logarithm, with base ). By supplying the option, you can set this parameter to a different value. The command LogTransform is the same as BoxCoxTransform, except you cannot supply the lambda parameter: it is fixed to always be .
If , then you can choose to use a different base for the logarithm by supplying the option. For example, to obtain the common logarithm, supply the option . It is an error to supply the option if is set to a value different from . The default base is .
Negative data points result in undefined values. To prevent this from happening, you can supply the option. The value is added to each data point before the transformation is applied. By default, is .
Applying a Box-Cox transformation may have the transformed time series being of a different order of magnitude than the original time series, and Box-Cox transformations with different values for the parameter may also have different orders of magnitude. If this is undesirable, for example when comparing an absolute measure of error involving the results of different Box-Cox transformations, you can supply the geometricmean = true option. This computes the geometric mean of each data set after the shift is applied but before the transformation is applied; then after applying the transformation, each data value is multiplied by this geometric mean, raised to the power . This can be viewed as preserving the units of measurement that the time series data is expressed in.
The TimeSeriesAnalysis[BoxCoxTransform] and TimeSeriesAnalysis[LogTransform] commands were introduced in Maple 18.
For more information on Maple 18 changes, see Updates in Maple 18.
Here are the log-transformed data.
Reconstructing the original data:
Apply the logarithm with base 10 instead.
We now apply the Box-Cox transformation with parameter to the sales data. We also apply the geometric mean correction.
Temperature data in Celsius is sometimes negative. These were the daily minimum and maximum temperatures in Waterloo, Ontario, Canada, averaged over a month.
In order to apply the Box-Cox transform, we need to shift the data by a number greater than minus the minimum value, .
Download Help Document


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The Return of the Giant NYC Dance Club
By Steve Weinstein
July 4, 1976 Was a Ramones-less Weekend in NYC
By Bryan Bierman
LIVE REVIEW: Karen O at McKittrick Hotel
By Lindsey Rhoades
Remembering Dee Dee Ramone's Rap Album
By Chaz Kangas
Meet Lady Casa, America's Most Famous Raver
By Ben Westhoff and Sarah Purkrabek
Ridiculous Kanye West-isms, In Illustrated Form
By Jena Ardell
Casting Martin Scorsese's New Ramones Movie
By Jesse Sendejas Jr.
A Tour Around Ace Frehley's Bronx
By Katherine Turman
It may seem inconceivable today that Parker, Gillespie, and Monk were initially derided as spinach, and yet they did contribute to the dismantling of the audience that embraced jazz in the 1930s, much as Coleman, Taylor, and Coltrane wore out many who came aboard in the 1950s. But they're in the pantheon. I'm concerned here with those who keep circling Olympus without quite getting a foothold, of whom the patron saint is Art Tatumthe virtuoso's virtuoso, the pianist's pianist, the musician's musician, who to this day, because he rejected a standard approach to linear improvisation, preferring juxtapositions that demand serious attention, worries many listeners into hapless indifference. His primary heir is the astonishing French pianist and composer Martial Solal, whose appearance at the Village Vanguard during the week of September 18 began with a half-filled house only partly attributable to the events of the preceding Tuesday.
Around the time Solal first visited America, in 1963, the forever staid Martin Williams got so heated that he closed his review alarmed that he might have written a "panegyric." "I do not mean that," he apologized, then cast about for a caveatsomething about Solal not being a natural blues player. He closed with reference to "Solalian lyricism," coining an adjective that has become so widespead in European jazzcrit that it sometimes gets a small s, though it refers less to lyricism than to a timeless fluency that transcends genre and idiom. Williams subsequently interviewed Solal for the Saturday Review. The pianist affirmed the influence of the bright, orchestral keyboard stylistsTatum, Waller, Garnerbefore absorbing Powell, from whom, he conceded, he took more than from anyone else save Tatum. He said he knew little of classical music after Debussy, putting to rest assumptions of an au courant academic educationin fact, like Monk, another influence, he found his method largely through the grammar of jazz. He also noted that he had not heard Bill Evans's records with Scott LaFaro and Paul Motian (a frequent Solal drummer) until arriving in New York, underscoring what his 1960 trio sessions with Guy Pedersen and Daniel Humair provethat he was striving for a triangular, equal-participation approach to the piano trio at the same time as Evans and Jamal.
Solal had been around. He was born in Algiers in 1927, and according to an old liner note was expelled from school in 1942 because of race laws (his father was Jewish). He turned to jazz after hearing Goodman, Waller, and Reinhardt, among others, and played piano, saxophone, and clarinet professionally, eventually realizing he would have to relocate to Paris to have a career. He made the move in 1950 and soon earned a reputation, appearing on Reinhardt's last session in 1953, working with visiting American players, writing orchestra charts, and scoring New Wave films by Melville and Godard. His 1960 trio made a tremendous impression, as did his ability to spontaneously recompose familiar themes. Solal's unaccompanied 1960 version of Tadd Dameron's "The Squirrel," for example, is a rigorous paradigm of virtuoso exultation kept in check by his uncanny control of formjust when you think the fingers will fly away, the gravity of the piece and his sense of proportion bring them home.
As of 1963, Solal was known here, if at all, for the movie Breathless and two enduring if little-remembered albums. In 1957, he had recorded with the New Orleans guru Sidney Bechet, at the older man's request; their mutual give-and-take, shown to advantage in robust exchanges on "These Foolish Things," proved that the generations could meet profitably at a time when they barely glanced at each other. Throughout, Solal shows originality, clarity, empathy, and a signal cleverness, as in the reharmonization of "It Don't Mean a Thing" or a "Rose Room" solo that simply extends his comping behind an uncharacteristically overwrought Bechet. The other album documented a 1962 concert at Paris's Salle Gaveau, beginning with a rhythmic deconstruction of "Jordu" and building tension with six knotty originals, including the dreamy ballad "Aigue Marine" (revived with greater radiance and polish in the 1979 version included in his invaluable out-of-print Radio France anthology, Live 1959/85), and "Nos Smoking," with its long expositiona crazy quilt of quick tempo adjustments, fleeting references that mate a silent comedy riff with bop changesthat caroms into an extraordinarily fast blues passage. The album was released here by Liberty (now owned by EMI, so a Blue Note reissue is in order), and it should have become a classicit's unlike anything else of the periodand established his stateside presence.
That didn't happen. Over the past 38 years, Solal has performed at festivals in Chicago and Monterey, but has rarely appeared in New Yorkthe Vanguard gig represented his first visit in two decades and his first club date since he hit the Hickory House in 1963. His records are often hard to find here, though a few have crossed the Atlantic, including the 1983 Soul Note, Bluesine, and the current series on Dreyfus: In & Out with Johnny Griffin; the stunning Just Friends with Motian and Gary Peacock, an ideal introduction; and the new Dodecaband Plays Ellington, which shows off his arranging skills at the helm of a band he has led since 1980. Solal's writing, like his playing, never stands still. They are alike in other waysthe saxophone that skitters away from the theme might be a right-hand arpeggio; the high voicing of two soprano saxes might be a dissonant thumping in the treble and the trombone slur a bass-clef response. Occasional episodes are too intricate for their own good, but like they say about the weather in the plains, if you don't like it, wait eight bars. Solal shows no interest in aping Ellington. He is attracted to tunes we know so well that they can flit in and out of view (along with odd quotes, like "Reveille" in "Satin Doll"), always centered in his broad variational dramas: How timely are those impending storm clouds at the start of "Caravan," a 15-minute stream-of-consciousness desert song with who knows how many references to Solal's years in Africa.
Still, the Dodecaband lacks the romping joy and surprise of his trio, which, with drummer Bill Stewart and bassist François Mouton, gave the Vanguard a palpable lift. Sticking to standards, he played a vivacious shell game with the themes, sometimes keeping them hidden until well into the piece, yet filling out the changes so comprehensively that the melody, when it did appear, seemed his only natural conclusion. Solal's virtuosity is inescapable. I think the intellectual aspect that either draws your attention like steel filings to a magnet or leaves you on the outside is his devotion to good old theme-and-variations. Most jazz performances follow that dictate, but so often the improvisation abandons the theme that we tend to think of the result as head-and-solo, which is very different. Solal, like Monk or Rollins, is constantly playing with the piece under scrutiny. Obviously, you don't have to know the song to find his inventions spellbindinghis original pieces are just as compelling. But you do need to know "The Song Is You," "I Can't Get Started," and "Tea for Two" to keep up with the wit, caprice, mystery, and implacable sense of structure that informs every selection.
Even then, he will throw a wrench into the mix, usually to leaven the set, for example, a brief, faithful rendering of "La Vie en Rose," in which the real variations were assigned Mouton, who has a neat trick of rapidly sliding a fretting finger down a string while plucking melody notes that seem to sparkle like a percussive piano arpeggio; or opening a number with Stewart playing buoyant triplets as prelude to "Round Midnight" (the source of several Solal triumphs, all strikingly different), treated as a waltza fast waltz at that. "What Is This Thing Called Love" and its shadow melody "Hot House" became a world of fragments while sustaining, measure for measure, the logic of a theorem. Using chords as a grounding point, he is as free in his movements as free jazz can be. His influences were assimilated so long ago that you would be hard-pressed to hear a touch of Tatum or Powell or Garner or Monk. What you do hear of them, beautifully transmuted, is a lineagethe whimsy, spark, and bemused craft of the inspired quick-change artist. Everyone around me was smiling.
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Beth Fertig
Beth Fertig is the contributing editor for education, covering the New York City public school system for WNYC on air and online at SchoolBook.org. She has covered education in the city for more than 15 ...
Summer's coming to an end and that means it's back to the classroom for millions of students around the country.
It's also back to school for the businesses trying to make a profit from teaching the nation's children.
Whether they're selling digital textbooks and educational services or running for-profit schools, established technology, media and publishing companies, as well as a fleet of start-ups, are seeing dollar signs and investment opportunities in the classroom.
Rupert Murdoch's News Corp is pushing into the digital textbook market with its education division, Amplify. Barnes & Noble, Apple and Amazon are all offering eTextbooks. And here in New York City, education entrepreneur Chris Whittle is opening a private for-profit school in Manhattan called Avenues for 700 to 800 students. Tuition is $39,750.
So is all this money being funneled toward the education sector actually helping students?
This week on "Money Talking," WNYC's contributing editor for Education Beth Fertig and Rana Foroohar of Time weigh in on the private sector's growing influence in the classrooom and what it means for the future of American education.
Email addresses are required but never displayed.


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Williams Selyem Coastlands Pinot Noir 2007
Pinot Noir from Napa Valley, California
Winemaker's Notes
Aromas of wild blackberries, cassis, cola and truffles fill your nose at once. Concentrated flavors of wild raspberries, Asian spice, espresso, cardamom and forest floor develop throughout the broad mouth feel. Extracted rich grape tannins are felt across your palate but carry nicely through with racy acidity in the finish.
Critical Acclaim
International Wine Cellar - "Inky ruby. Potent aromas of blackberry, boysenberry and dried rose, with exotic Indian spice and gingerbread nuances adding complexity. Deep, fleshy dark berry flavors show liqueur-like depth and intensity, with slow-building tannins adding grip and structure. Develops more vibrancy and red fruit character with aeration and finishes with outstanding clarity and sappy persistence. This is another '07 from Williams-Selyem that calls for patience.
Rating: 94(+?)"
The Wine Advocate - "The deepest-colored of these Pinots is the 2007 Pinot Noir Coastlands Vineyard. The opaque ruby/purple color is followed by a tight but promising nose of black currants, black cherries, black raspberries, flint, and earth.
Rating: 93+"
Wine Enthusiast - "This is one of the darkest of Williams Selyem's new Pinots and also one of the ripest. It's jammy in the intensity of raspberry and cherry fruit, with a savory, Dr. Pepper cola richness. The spiciness, which is one of winemaker Bob Cabral's specialties in capturing, is exotic. Cellar Selection."
- View All
Williams Selyem Winery
Williams Selyem Winery began as a simple dream of two friends, Ed Selyem and Burt Williams, who pursued weekend winemaking as a hobby in 1979 in a garage in Forestville, California, and made their first commercial vintage in 1981. In less than two decades, Burt and Ed created a cult-status winery of international acclaim. Together they set a new standard for Pinot Noir winemaking in the United States, aligning Sonoma County's Russian River Valley in the firmament of the best winegrowing regions of the world. Today John and Kathe Dyson, who purchased the winery from Burt and Ed in 1998, carry on the passion for Pinot Noir winemaking without compromise. As for the wines... they just keep getting better and better. View all Williams Selyem Winery Wines
About Napa ValleyView a map of Napa Valley wineries
It's hard not to think of Napa Valley when thinking of California wines. The region is, after all, the one that brought world recognition to California wine making. The area was settled by a few choice wine families in the 1960's who bet that the wines of the area would grow and flourish. They were right. The Napa wine industry really took off in the 1980's, when vineyard lands were scooped up and vines were planted throughout the county. A number of wineries emerged, from large conglomerates to small boutiques to cult classics. Cabernet Sauvignon is definitely the grape of choice here, with many winemakers also focusing on Bordeaux Blends. Whites are usually Chardonnay and Sauvignon Blanc.
Notable FactsWithin the Napa Valley lie smaller sub-AVAs that lend even more character specifics to the wines. Furthest south is Carneros, followed by Yountville, Oakville & Rutherford. Above those two is St.-Helena and finally, just grated an AVA, Calistoga. These areas are situated on the valley floor and are known for creating rich, smooth Cabernet Sauvignon, Merlot and Chardonnay. There are a few mountain regions as well, nestled on the slopes overlooking the valley AVAs. Those include Howell Mountain, Stags Leap and Mount Veeder. Wines from the mountain regions are often more structured and firm, benefiting from more time in the bottle to evolve and soften.
About CaliforniaIt's not rare to see a wine's country of origin listed as "California." A country into itself in the wine world, California makes enough varieties and styles to match many European wine countries. It produces a diverse range of wines that span the quality spectrum.
The most famous of the California wine regions is Napa Valley, and these wines are certainly outstanding – but it's not as broad and diverse as its larger neighbor, Sonoma County. Down south, Santa Barbara's Santa Maria Valley is well-known for its Rhône blends, as well as cool-climate varieties like Pinot and Chardonnay. The Central Coast, the largest California AVA, has many different microclimates that lead to a wide range of wines with many sub-AVAs.
Customer ReviewsSign In to Add Your Review0 }div>Related ProductsUsually this vineyard produces a more feminine wine, but the 2008 version is a bit bigger. Multifaceted aromas of wild ...Alluring red cherry and vanilla immediately jump from the glass but give way to deeper notes of smoked meats, grilled ...High above the town of Occidental on the Coast Range, the Coastlands Vineyard is influenced by ocean fog and cool ...
Alcohol By Volume GuideMost wine ranges from 10-16% alcohol by volume. Some varietals tend to have higher (for example Zinfandel and Cabernet Sauvignon) or lower alcohol levels (Pinot Noir and many white varietals), but there is always some variation from producer to producer. Some wine falls outside of this range, for instance Port weighs in closer to 20%, while Muscat and Riesling are usually a bit below 10%.
Wine Style Guide
Light & Fruity
- Red wines that are more fruit-forward and lighter in tannin and body.
Smooth & Supple
- Medium bodied reds that go down easy, with smooth tannins and supple fruit.
Earthy & Spicy
- Wines where earthy and/or spicy dominate the flavors – typically medium to full body.
Big & Bold
- Full bodied wines that have concentrated fruit and are higher in alcohol and/or tannins. Some need age.


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Check Your Credit Finance Insurance Boat Transport
Boat Description
A versatile luxury motor yacht with contemporary styling and aft cabin layout
The luxurious Broom 395 is as at home CRUISING inland waterways as it is taking to the open sea. The versatile aft cabin layout ensures you will be at ease both on river and at sea, without compromising on living space whilst relaxing in the harbour. Optimised to provide comfort and convenience for four, the proven hull and superstructure are complemented by contemporary deck styling features and INTERIOR DESIGN. Promoting sleek design and bespoke styling, whilst retaining all the practical features you'd expect from a Broom boat.
Broom 395 - cruising without limits
Aft cabin layout allows larger living space in a more compact boat making it practical for use on inland waterways, and the semi-displacement hull makes for comfortable sea exploration.
|13 ft
|Max Draft
|3 ft 6 in
|Dry Weight
|22488 lb
|Hull Material
|Hull Shape
|Modified Vee
|Length Overall
|39 ft 6 in
|Number of Heads
|Max Bridge Clearance
|10 ft 8 in
Hull Design and Construction


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PGPD News Blog
Hit-and-run driver in Chillum returns to scene, now in custodyComment
Police say the driver did not remain on the scene after the 49-year-old man was hit on Ager Road on Saturday night, but he returned Sunday morning.
RecommendedRecent Facebook Activity
Only On 7
ABC7 News at 4 Now Weekdays!ABC7 is giving you MORE news in your afternoons with an extra hour, an hour earlier! Join ABC7's Leon Harris and Alison Starling for what's trending in your community and world. Every weekday afternoon at 4pm right after back to back "Hot Bench" shows at 3pm on ABC7.


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Sport - Elec® Shiatsu Massage Cushion
Item # WX2-217381
- Google+
- Details & Specs
End the aches and pains! Sport - Elec® Shiatsu Massage Cushion, SAVE BIG BUCKS !
Invigorating, kneading massage for your neck, back, waist and thighs. Shiatsu action relieves muscle tension and acts to increase your blood circulation. Vibrating motors relax your body and improve metabolism. Includes both home and car power adapters, bringing sweet relief from your office to on the road to your living room! Here for LESS!Relax:
- Imitates the action of human hands to knead, press, roll and vibrate
- Multi-massage heads cover large areas
- 4 kneading heads "walk" up or down to work on your whole body at once
- Choose between full back, lower back or upper back massage routines
- Remote control for easy operation, slips into its own sewn-in pocket. Car and home AC adapters. 120V. UL-listed. 41 x 19"w. 9 lbs., 7 ozs.
!!! Limited Quantities !!!
- Reviews
Sport - Elec Shiatsu Massage Cushion is rated out of 5 by 1.Rated 5 out of 5 by KENNETH R from Good valueDate published: 2012-02-04
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BY Lucas Grindley
January 07 2012 5:32 PM ET
Rick Santorum continued his string of antigay pronouncements while on the trail in New Hampshire, saying a man in jail would be a better parent than a same-sex couple.
The Los Angeles Times reports from Manchester, New Hampshire that Santorum claimed to quote an anti-poverty expert while explaining his case.
"He found that even fathers in jail who had abandoned their kids were still better than no father at all to have in their children's lives," Santorum told voters about the researcher, according to the Times.
If a same-sex couple were to raise a child, they would be "robbing children of something they need, they deserve, they have a right to. You may rationalize that that isn't true, but in your own life and in your own heart, you know it's true."
This isn't a new theme for Santorum and it potentially sets him apart from other Republican candidates for president. While in Iowa, where he finished behind Mitt Romney by eight votes, Santorum signed a pledge from the Iowa Family Leader that proclaimed his belief that same-sex parents are inferior to straight ones. Romney and Ron Paul did not sign the pledge, and Newt Gingrich inexplicably ignored that portion in his letter to the group backing only parts of it. (Gingrich's lesbian step-sister, Candace Gingrich-Jones, told The Advocate in December that she and her wife would like to have children.)
We can think of at least one person who would disagree with Santorum on whether kids raised by LGBT parents are robbed of anything. Watch video below of Zach Wahls, an Iowa college student who spoke eloquently last year before his state's legislature about why his moms should be allowed to marry.
- Where in the World Are the Happiest Gay Men?
- WATCH: Alabama Jails, Fines Minister After Performing Lesbian Wedding
- REPORT: Bisexuals Face Biphobia at Doctor's Office, LGBT Groups
- #TBT: Selling the Male Body
- EXCLUSIVE: Watch the Official Trailer for 54: The Director's Cut
- Poised for Perfection: Sgt. Shane Ortega Puts a Face to the Transgender Military Ban


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Top Schools with Archaeology Graduate Programs
Learn about graduate degree programs in archaeology offered by two of the top schools in the U.S. Discover the schools' rankings, degrees offered and program curriculum.
Schools Overview
Two of the most well-known American universities, Yale University and Columbia University, offer excellent archaeology programs at the graduate level. Both are located on the East Coast of the US and have been ranked by the U.S. News & World Report among the top five best universities in the nation. The archaeology graduate programs can prepare students for a range of cultural careers, not excluding education. Although Yale offers a master's degree program, Columbia University offers both master's and doctoral programs, which may be personalized in conjunction with other departments at the university. Read on for more information about graduate archaeology programs available at two of the best schools in the country.
Best Archaeology Graduate Schools
1. Yale University in New Haven, CT
Yale University is third on the U.S. News & World Report 2011 list of the best universities in the nation. Its master's program in archaeological studies is composed of eight courses and requires a graduate thesis. Students are given three years to finish this degree program.
Yale's master's program prepares students for a variety of careers in education and cultural areas. The program also provides continuing education for archeologists and other professionals. Course credits are designed to be transferable to schools that offer Ph.D. programs in this field.
2. Columbia University in New York, NY
Ranked fourth on U.S. News & World Report's 2011 list of top national universities is Columbia University.
Columbia offers Master of Philosophy and Doctor of Philosophy programs in archaeology through its Department of Anthropology and Department of Art History and Archaeology. Students can also arrange Ph.D. programs with other departments at the school, including the Department of History, Department of Classics, and Department of Middle East and Asian Languages and Cultures. The Columbia Center for Archeology coordinates these various programs and offers fieldwork, research, and internship opportunities for archaeology students.
List of Top Schools with Archaeology Graduate Programs by Student Enrollment
|School Name
|Arizona State University
|Archaeology graduate program ranked 5th in the nation by the Society for American Archaeology
|Tempe, AZ
|Cornell University
|Cornell Institute of Archaeology and Material Studies has field schools in several locations, including Bulgaria, Armenia, Cyprus, Israel, St. Croix and Italy
|Ithaca, NY
|Johns Hopkins University
|Johns Hopkins Archaeological Museum collection includes artifacts from ancient Greece, Rome, Egypt, the Near East, and the ancient Americas
|Baltimore, MD
|New York University
|Anthropology department maintains connections with groups like the Smithsonian Institute, American Museum of Natural History and the Center for American Archaeology, which help to provide opportunities for students
|New York, NY
|Ohio State University
|Archaeology graduate students pursue field work in Eastern U.S., Europe, Mesoamerica and the Near East
|Columbus, OH
|Stanford University
|Stanford Archaeology Center gives students access to two workshop-style seminars per week, as well as four lectures from distinguished individuals in the field each year
|Stanford, CA
|University of California - Berkeley
|Ancient History and Mediterranean Archaeology program students and faculty currently conducting research in Turkey, Jordan, Egypt and Greece
|Berkeley, CA
|University of California - Los Angeles
|University is home to the Cotsen Institute of Archaeology, which conducts research in more than 20 countries, in addition to research objectives in the western U.S.
|Los Angeles, CA
|University of Florida
|Florida Museum of Natural History is located on the university's campus and it facilitates grad student research in areas like Haiti and the Dominican Republic, as well as locations around Florida
|Gainesville, FL
|University of Texas at Austin
|Students can conduct research on the ancient Mayan civilization through the university's Programme for Belize Archaeological Project
|Austin, TX
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Weather by Ömer ÜCEL
1,000 - 5,000 downloadsAdd this app to your lists
Tweets por @Appszoom
+ By Ömer ÜCEL
This application presents weather information for your current location with simple interface . Also you can check out 7 or 10 day weather forecasts.
Recently changed in this version
* Removed disconnection status activity.
* Removed useless gift activity.
* Finding a location service has been fixed for some devices.
Comments and ratings for Weather
(62 stars)
The app has a wrong city set,, would be nice to be able to change it
(62 stars)
Really like the simplicity ity of it. Would be awesome to have a widget as will though.


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|Property type
|Minimum Stay
|4 nights
Everything about this apartment is top of the line, first class and immaculately clean. It is new construction and designed by Manual Glas, a leading New York architect. Two master bedrooms feature private en-suite bathrooms with new designer linens and towels. Beds and mattresses (king size) are new as is all furniture, floor coverings and accessories.
Kitchen is all new Miele appliances and designer decorated. Perfect for private dining or entertaining.
There is a large and completely private paved terrace directly located outside kitchen/living room and at that level. The 650 square foot terrace offers new, all weather upholstered Gloster furniture, dining seating for 6 at an antique, in-laid Roman table, and a professional landscape. Matching water fountains and lights add a sense of tranquility and peace to the setting.
While the location is quiet and tree lined, we are one block from the 4, 5, 6 ( ''The Lex'' Subway in New York parlance) and cross town bus lines.
This is an extremely convenient location to all of Manhattan.. Up, Down, East or West.
We rent only to responsible guests who want the best of New York in a quiet, quality environment. Accordingly, we do ask our guests to provide a description of themselves and their party in terms of age, profession and backgrounds. No pets. No young children. No smoking. Minimum four nights.
Our check-in hour is 3PM and check out is 11AM, although we are flexible on both when circumstances permit. Please check our calendar for availability. It is always up to date.
A great home starts with a great owner, and that is what Livingston is. He makes you feel as if you are dealing with a good friend. I highly recomend staying at his property. As for the unit, there is not much else I have to say that has not been said in the other reviews. It is a great place to enjoy a relaxing NY experience!
I like luxury and my husband does not do lifts (elevators), so finding a place to stay for a week in New York with plenty of room to relax in was a bit of a challenge. This apartment was perfect for us. It was very spacious and luxurious and beautifully decorated and I loved the marble bathrooms. The photos do really prepare you for the sense of space and calm you get when you enter. There was no noise at all. It was a real pleasure to meet Livingston and have a chat, it really gave a personal touch to our stay, and he directed us to a great Italian restaurant. In fact, we could not go wrong with the food in this part of New York, everything we tried was delicious, and some of it great value for money too.
New York City is a busy place, and that's the attraction. But when you're ready to relax in your own quiet oasis, this is an excellent choice. Comfortable and well appointed with plenty of great restaurants nearby. All the great reviews that drew us here were confirmed. Thanks Livingston.
Many Thanks to the very gracious host, Livingston, for sharing this amazing property with us! The location, amenities and ambiance of this home are unrivaled. All the reviews are accurate--this is an extremely quiet oasis in the city, yet one of the most convenient locations to walking destinations or transportation you could find. We were constantly amazed at the abundance of available cabs right outside the door, even on a rainy Friday evening! No detail has been overlooked in the appointments or cleanliness of this incredibly beautiful space. The terrace--which looks too good to be true--is actually every bit of the gorgeous haven it appears to be in the pictures! The split suite layout is fantastic for two couples or families, and again, I will reiterate that it is remarkably quiet in this heavenly apartment. We appreciated that there is a wonderful grocery two blocks away so that we purchase what we wanted for a leisurely breakfast in the mornings. Several evenings we walked to one of many great and conveniently located restaurants in the Gramercy Park area, and on occasion, took a brisk morning walk for exercise down to the village and back. Not only would we recommend this property to friends or relatives, but we do hope to return ourselves. Livingston is a most accommodating host; he has created a perfectly safe, comfortable and extremely elegant spot for appreciative visitors. Thank you again for your hospitality.
This is an excellent property in a very central location of Manhatten. The apartment is very modern, well amenitized, and has ample room for a comfortable Manhatten stay. The quality and size of the apartment relative to staying in a hotel is completely unmatched!!!! Further, the owner went out of his way to make sure we had a comfortable stay. He was very attentive and available for any questions, etc. The pictures, descriptions of the property very accurately depicted the actual property. I've stayed in many VRBO rented properties throughout the US this is definately among the best!!!!! Five Stars!!!!!
As I had come to New York for surgery this apartment truly offered a haven for my recovery and Livingston could not have been more accommodating.
The apartment is in a great location, with restaurants, deli's and grocery stores mere minutes away. It's easy to grab a cab at any time day or night from in front of the apartment building, and the neighborhood is great.
Having been to New York previously and stayed in a hotel a few blocks away I was impressed at how quiet it was inside the apartment. The apartment is beautifully furnished, immaculately clean, and with all the comforts of home. The outdoor patio is a bonus for New York and a great place to sit and enjoy breakfast or just read a book.
I have already recommended this apartment to all my friends and have to say it is even better than the photos portray.
Other Activities: shopping, health/beauty spa
|Rate Period
|Weekend Night
|Monthly *
My Standard Rate
4 night minimum stay
|Refundable damage deposit
|Cleaning fee
|$175.00 + Tax
|Tax Rate
Payment by personal check, bank wire or PayPal (+3%).
One half the rent to book property. Balance due 30 days prior to arrival.
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.


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- Shopping Bag ( 0 items )
Posted December 9, 2008
The bottom line has improved considerably at Star Risk, an interstellar security service firm, but the company still remains in some trouble. Thus, when Josiah Williams wants to hire them, the company does not care what he needs they will do almost anything for the right price.----------- Williams¿ client, a confederation of labor unions, is in the middle of difficult acrimonious negotiations. He will pay a fortune for Star Risk to employ a mercenary force to blockade a remote system that will force management to its knees begging for a settlement favorable to the union alliance. Preventing exporting of products is an easy job for Star Risk so they accept especially since the terms include a hefty sum for the firm. However, sometimes the simple turns out more dangerous and complex as Williams has only provided an iota of what is going on. The Star Risk squad all think the same thought that those who inherit their portion of the credit fee will thank them posthumously for making them such easy money.---------------- Paying homage to the late Chris Bunch, who created the Star Risk mercenary science fiction thrillers, Steve and Dal Perry provide a terrific entry in the outer space saga. The story line is action-packed, but it is the conspiracy that makes for a fine time as the crew believes once again they feel like THE DOG FROM HELL as victims of THE DOUBLECROSS PROGRAM. Fans will enjoy this smooth well written interpretation of Chris Bunch¿ military mercenaries in space.----------- Harriet KlausnerWas this review helpful? Yes NoThank you for your feedback. Report this reviewThank you, this review has been flagged.
Posted January 4, 2011
No text was provided for this review.
Posted July 26, 2009
No text was provided for this review.


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2011 release renamed to: G STRING BETA. The Dec. 19 2011 release is now referred to as a beta release- read the mod's "news" to see why. Download the beta in the mod's "downloads" section.
Dec 25th, 2011 7 people agree 1 person doesn't
I'm not done with this mod yet. However, I feel like I've played enough to offer a complete opinion (and I wish I had more text characters with which to give it.) This mod is incredible; incredibly made, incredibly flawed.
Made: I adore the atmosphere; so much that I can scarcely quantify my adoration with an explanation. I adore how eeriely uncanny and plausible the vast vistas of desolation and future decay feels. I adore how it bravely wears its politics on its sleeve without actually shoving it in your face, a masterstroke of subtlety. Nothing feels grafted into this world, a world where the machinations of progress itself feel grafted onto every aspect of human life, and often for the worse. I adore this sense of danger and mystery you've so deftly crafted; words cannot describe how I felt, walking onto a ruined street and being genuinely fearful for what lay ahead, from the strange and terrifying things I would face to the sheer dessication the path ahead promised. I adore how unique this has been.
Flawed: The story is practically nonexistent and, when it's there, shockingly opaque. C-zom has more eloquently summed up my misgivings. Strangely, I don't really care, although this mod is in painful, desperate need of subtitles. I don't understand half of what any of the characters say. The shooter sequences are staggeringly inefficient and clumsy (dealing with the Combine-stand ins was almost never fun. Those robots, though? Golden. Amazing. Terrifying.) I feel like I have to do a puzzle every five seconds, for all the obstacles and obtuse paths you shove in our way. Again, that last point is not always a bad thing; I enjoy having to think on my feet. Sometimes.
Any other mod would receive at least a 7 for the above flaws, if it were a normal HL2 mod. But this is not normal: it's something special, horrifying, and ultimately unique, and for that it deserves a 9. Well done.
May 9th, 2012 2 people agree 0 people don't
I joined up with ModDB for the express purpose of rating this mod.
Excellent, most excellent!
It still needs a little work, a few more encounters with different types of creature - a few bugs here and there.
But overall this is one of the best mods you are likely to find out there, for this or any other game!
People who didn't play to the end are missing out. The last couple of maps are really epic. A good mix of action, as well as the conclusion of the story.
Watching the main character's power grow to its conclusion is just amazing, and satisfying.
Feb 14th, 2012 3 people agree 1 person doesn't
An original concept brought to life by vast environments, unique models and an interesting story.
Dec 27th, 2011 3 people agree 1 person doesn't
Amazing work, each areas are like a puzzle, looking for a way to pass through obstacles. The views of tokyo twice from a skyscraper are breathtaking.
Dec 28th, 2011 4 people agree 2 people don't
You should really be proud of yourself for this, as far as dystopian scenery and in-game atmosphere goes, you might as well have written the book. The environs live and breathe an atmosphere of oppression, desolation, and past calamity. They are fully engaging, and many times I've caught myself being distracted from the game by how much depth and detail was put into the world you've created. I only wish the gameplay matched how great this mod looks.
For the majority of the levels, it feels like you did either very little playtesting, or simply wanted it to be confusing. There were many parts where I was impeded because I missed something obvious that you placed far too inconspicuously. Another issue of note is the player characters weapon animations. The hammers animation is awful, it looks like instead of hitting with it, you just recoil with the hammer; it makes no sense at all. The psychic powers are a nice plot device, but ultimately feel largely underwhelming, as I always seemed to favor the usage of firearms every time. The plot was also hard to follow in some parts, and really left me direly wanting to know what was going on, and you need some goddamn subtitles. Seriously, your characters are really hard to hear.
In conclusion, this mod feels like you have your image in mind, but you forgot everyone else doesn't. The world you've created is just fantastic, a real joy to behold; but from the standpoint of the player, it's confusing, hard to navigate, and it's seldom clear where you're going. Both in terms of the plot, and in the level itself. Ultimately though, with a little bit of gumption and some tolerance, any player can tough through the rough patches in your mod, and hopefully enjoy all the work you put in.
Jan 13th, 2012 5 people agree 3 people don't
While Gameplay wise it suffers from a lot of flaws the mayor strenght of this mod lies on its ambiance and artwork. It brought to me something that I have not experienced in a long time while playing videogames and that is "wonder". Keep up the good work.
Mar 24th, 2013 1 person agrees 0 people don't
G-String came out over a year ago, and I started playing right when it launched and it was one of the most infuriating mods I've ever played. It often hurts to play, your eyes strain, your head starts to hurt as you try and find a way through these brush-based maps with strange models that I never figured out were terrible or just okay. Alot of maps just say no to general game design about making it obvious where to go, and you find yourself doing trick jumps to see if thats where you're supposed to go.
But this says 9/10 for a reason. This game gets personal for those who've played it. Myo becomes this character you legitimately care about, leading her through these dangerous areas against awful odds because its the only way forward. The art style gives this oppressive feeling, this heavy atmosphere thats unparalleled in any game I could think of, it goes beyond a good setting, this world of metal and sorrow and plastic breathes despite the somewhat blocky mapping, but mod cant get above a 6/10 if the gameplay sucks, but G-String managed to surprise me here. This goes beyond just a nice setting and a good protagonist, this is interesting, oldschool and somehow unique and revolutionary gameplay. The combat is hl2 + a slowdown mechanic with fireballs (Now that sounds awesome but I forgot I had it for 90% of the game so whatever.) so the combat works. the enemy numbers and spawns and ranges all work, youll find yourself overwhelmed sometimes, and some really hard parts, but that spices the game up and its nice to have punishing areas spread out, as opposed to a whole game like that.
I have to say though, the crown on this game is the aforementioned mapping. These maps may not be super realistic (as I said before it's almost all brushes) but the atmosphere and textures and layout fit together so well, it transcends maps and turns into a world, its impossible to explain. You well get lost, you will be mad at maps, but it works because it fits perfectly.
Jan 12th, 2013 1 person agrees 0 people don't
This is a special mod, made by a special person. Superb mapping, challenging gameplay, fitting music, realized world with a unique atmosphere reminiscent of Akira, Bladerunner, Star Wars and it has some references to other sci-fi's like THX (buy more, be free),
Soylent Green (pollution), V for Vendetta (revolution storyline),
Deus Ex (cybernetic augmentation), Akira (special individuals awaken to psychic powers). Very long 10+ hours with a storyline that draws you not just for immersion but to think about humanity/morality and gives us the most epic finale I've ever seen in a game.
I can't give this justice enough, you'll just have to play it.
Its not without its issues, books have some weird physics and you get some jerky movement over debris & other objects, crouch speed is way to slow and the pyrokinesis doesn't seem to do anything (wish you could set people on fire). Some areas are nonsensical like having to jump down into crater ledge with no way up, crawl around into a bit of exposed pipe that you didn't know would be there that by miracle is not caved in... I wouldn't go there :/ No one would.
No crosshairs makes combat really awkward, anyone can look down the sights of a gun, thats the first thing you learn. The crosshair symbolizes this without restricting our vision to much. Some people complain about the black bars, personally I think it fits cutscenes and not so much the general gameplay.
Dec 22nd, 2011
2 people agree
1 person doesn't
This review may contain spoilers
The only flaw in this game is that there seems to be no instructions that would be necessary in certain parts. I wouldn't know to paddle across that toxic water on wooden board without jumping in dieing a few times and straight up guessing. However this game was a great experience and you should be praised for your efforts. Probably the best mapping I have seen in a source mod.
Oct 12th, 2014 0 people agree 0 people don't
Absolutely outstanding, I can not call this a mod, but as a stand alone game. This game does not exceed what some others have put out, but that said this is a great game. Getting lost can be frustrating, and every part is clearly thought out, I can say with honesty that this sits as one of my favorite games of all time. I am looking forward to version 2.


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