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Isolation and characterization of tumor stem-like cells from human meningiomas
- Dueng-Yuan Hueng,
- Huey-Kang Sytwu,
- Shih-Ming Huang,
- Chen Chang,
- Hsin-I Ma
- … show all 5 hide
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Recent advances in research have found that tumor stem-like cells are resistant to surgery, radiotherapy, and chemotherapy. Tumor stem-like cells play critical roles in tumor recurrence, angiogenesis, and invasion in malignant brain tumors. However, the identification of tumor stem-like cells in meningiomas has not been clarified. In this study, we identified the stem-like features of sphere-forming cells in human meningiomas. The results showed that meningioma stem-like cells possess the ability to form spheres in identical stem cell culture condition. These meningioma sphere cells (MgSCs) expressed progenitor cell marker, CD133, but not differentiated cell marker, epithelial membrane antigen (EMA) on immunofluorescence staining. Importantly, the mRNA expression of ABCG, and CD133 was higher in MgSCs than daughter meningioma adherent cells (MgACs). In addition, cells displayed chemotherapeutic resistance to vincristine more in MgSCs than MgACs. This phenomenon was also found in single cell form from dissociated spheres than MgACs. Moreover, MgSCs are more resistant to irradiation treatment than MgACs. Furthermore, MgSCs revealed high tumorigenicity in vivo following orthotopic inoculation into the brains of immunodeficient mice. The corresponding immunohistochemical (IHC) staining found that MgSCs are positive for EMA, vimentin, and CD133, consistent with IHC of primary human meningiomas. These findings have provided better understanding of meningioma cell biology and suggested that meningioma stem-like cells may serve as a novel target in therapeutic resistant meningiomas.
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- Title
- Isolation and characterization of tumor stem-like cells from human meningiomas
- Journal
Journal of Neuro-Oncology
Volume 104, Issue 1 , pp 45-53
- Cover Date
- 2011-08-01
- 10.1007/s11060-010-0469-1
- Print ISSN
- Online ISSN
- 1573-7373
- Publisher
- Springer US
- Additional Links
- Topics
- Keywords
- Chemoresistance
- Meningioma
- Radioresistance
- Sphere
- Tumor stem-like cell
- Industry Sectors
- Authors
- Dueng-Yuan Hueng (1) (2)
- Huey-Kang Sytwu (2) (3)
- Shih-Ming Huang (4)
- Chen Chang (5)
- Hsin-I Ma (1) (2)
- Author Affiliations
- 1. Department of Neurological Surgery, Tri-Service General Hospital, Graduate Institute of Medical Sciences, National Defense Medical Center, 325, Sec. 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, ROC
- 2. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
- 3. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
- 4. Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, ROC
- 5. Institute of Biomedical Science, Academia Sinica, NanKang, Taipei, Taiwan, ROC

subset: commoncrawl


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Book your room at Super 8 Yreka Ca
Standard Room, 1 King BedMax Occupancy: 3 guests (up to 2 children)
Standard Room, 1 King Bed, SmokingMax Occupancy: 3 guests (up to 2 children)
Standard Room, 2 Queen BedsMax Occupancy: 5 guests (up to 4 children)
Standard Room, 2 Queen BedsMax Occupancy: 5 guests (up to 4 children)
Motel in Yreka with free breakfast and seasonal outdoor pool
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Rooms provide conveniences like refrigerators and microwaves, plus WiFi and LCD TVs with cable channels. Other amenities available to guests include coffee makers, hair dryers, and safes.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Public areas are equipped with complimentary high-speed wireless Internet access. This motel offers access to a business center. Guests can enjoy a complimentary breakfast each morning. This Yreka motel also offers a seasonal outdoor pool, laundry facilities, and RV/bus/truck parking. Onsite self parking is complimentary.
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- Free Wi-Fi
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Available in all rooms: WiFi (surcharge)
Available in some public areas: Free WiFi
Free self parking, RV, bus, truck parking
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- WiFi (surcharge)
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Guests are offered a complimentary continental breakfast each morning.
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Check-in time starts at 1 PM
Check-out time is 11 AM
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Children and extra beds
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Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
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A new cultivation method using electricity could help scientists reproduce iron-oxidizing bacteria in the lab. The bacteria "eats" the electrons in iron, causing rust, and has been characteristically difficult to grow in a lab. Electrochemical cultivation is a "new way to cultivate a microorganism that's been very difficult to study. But the fact that these organisms can synthesize everything they need using only electricity makes us very interested in their abilities," says Daniel Bond, a co-author of the study published in the American Society for Microbiology.
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Updated 05/12/2014
A distinctly upper-crust northern European feel pervades the peach stucco walls and elegant rooms here; the hotel sits just north of the western end of Worth Avenue, and high tea, a cigar parlor, and daily turndown service recall a bygone, more refined era. The inviting rooms range from compact to spacious, and all have been redone and include plush upholstered chairs, original paintings, and marble baths. Settle on a leather couch near the cozy library's fireplace and peruse an international newspaper or classic book, or have a cigar in Churchill's, the only public smoking room on the island. Room keys here are still brass, and maid service is twice-daily. A quiet area surrounds a large pool where you can relax, and the Leopard Lounge draws a convivial crowd. The courtyard café is a hit with locals and guests.
363 Cocoanut Row, Palm Beach, Florida, 33480, United States
561-659–5800; 800-243–7871
Website: www.chesterfieldpb.com
Hotel Details:
Updated 05/12/2014
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Le Tour's foreign aces wary of hot Luzon ride
Foreign riders from continental and international teams quietly slipped into the country in the past few days to acclimatize themselves with the intense summer heat that could wear them down in the 2013 Le Tour de Filipinas.
First to arrive on Monday was Hong Kong-based Team Direct Asia, which settled in Pagudpud, Ilocos Norte, three days before the four-stage bikathon kicks off tomorrow in Bangui, a coastal town famous for its gigantic power-generating windmills.
Continental squad Polygon Sweet Nice (Malaysia) and club teams Perth Cycling (Australia) and Korail Cycling Team (South Korea) have also surveyed the scorching terrain all the way to Cagayan Valley since their arrival early in the week.
Stage One is a 175.5-kilometer ride on mostly flat terrain to Aparri, Cagayan, with the only climbing challenge presenting itself early in the race.
A huge group of continental riders checked in yesterday led by Tabriz Petrochemical (Iran), CCN Cycling (Taiwan), Terrenganu Cycling (Malaysia), OSBC Singapore and Atilla Cycling Club (Mongolia).
Race manager Paquito Rivas, a former Tour champion and Eagle of the Mountain, said the heat, recorded at an average of 37 degrees Centigrade the past few days, would definitely take its toll on the foreign riders.
"It's not getting cooler. That is why the strong sprinters and climbers are not the only ones who will enjoy an advantage, but also the riders who are used to high temperatures," said Rivas, a director of PhilCycling, the national association for cycling.
Led by continental teams LBC-MVPSF Cycling Pilipinas and Team 7-Eleven Roadbike Philippines, the Filipino riders also arrived in Pagudpud yesterday. Navy-Standard Insurance, Marines-Standard Insurance and American Vinyl are the other local squads.
However, some of the riders from Ayandeh Continental suffered injuries while training. The continental squad from Uzbekistan also pulled out of the Le Tour presented by Air21 in partnership with San Miguel Corp. and Smart.
The fourth edition of the Le Tour is part of the International Cycling Union Asia Tour.
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THURSDAY, Nov. 17 (HealthDay News) --Younger women who have a hysterectomy that spares the ovaries are almost twice as likely to go through early menopause as women who do not have their uteruses removed, according to a new study.
"Hysterectomy is a common treatment for many conditions, including fibroids and excessive bleeding," said the study's lead author, Patricia G. Moorman, an associate professor in the department of community and family medicine at Duke University in Durham, N.C., in a Duke news release. "Most women are very satisfied with the results of a hysterectomy. But this is a potential risk of the surgery that should be considered along with the benefit."
In conducting the study, published in the December issue of the journal Obstetrics & Gynecology, Duke researchers followed roughly 900 women between 30 and 47 years old for five years. About half of the women had a hysterectomy, but kept at least one ovary to retain hormone production and not increase their risk for bone loss, heart disease and other health problems.
Despite keeping an ovary, the study found that nearly 15 percent of the women who had hysterectomies experienced menopause over the course of the study, compared with only 8 percent of the women who didn't have the surgery.
Women who had one ovary removed were at the greatest risk for menopause, but even women who kept both ovaries were at increased risk, the study noted. The researchers estimated menopause for these women occurred about two years earlier than for their peers who didn't have a hysterectomy.
What causes a woman's ovaries to shut down after a hysterectomy is still unknown, the study's authors added.
"Some have hypothesized that surgery disrupts the blood flow to the ovaries, so the surgery leads to early ovarian failure," said Moorman. "Others have speculated it's not the surgery, but the underlying condition preceding the surgery that causes it
|Copyright©2010 ScoutNews,LLC.
All rights reserved


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Originally written on Fox Sports | Last updated 11/12/14
EAST RUTHERFORD, NJ - SEPTEMBER 19: Head coach Rex Ryan of the New York Jets throws passes before the game against the New England Patriots on September 19, 2010 at the New Meadowlands Stadium in East Rutherford, New Jersey. (Photo by Al Bello/Getty Images)
Another date with the New England Patriots has New York Jets coach Rex Ryan running his mouth. Nothing unusual in that. The fact his banged-up squad has the same record as New England, however, may be a bit more odd. Two of the four AFC East teams knotted at 3-3 continue their tense rivalry Sunday when the Patriots host the Jets. Facing the Patriots always seem to bring out an even more boisterous side of Ryan, who again expressed confidence despite his team being outscored 112-40 in losing the last three regular-season meetings. ''I want them to know, and they know, that I think we're going to beat them,'' Ryan said. ''I don't buy into all that other stuff. Look, I recognize they're a great football team and (Bill) Belichick's a great coach. I've never once said he wasn't, OK, but we're not going to back down or concede anything.'' Sunday's contest will give the winner an upper hand over the other in the division race, with the Jets trying to improve to 3-0 against East rival...
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Making a splash: Memphis Jewish Community Center camp nudges kids to dive into social interaction
The massive pool at the Memphis Jewish Community Center stood as common ground for various summer campers Wednesday afternoon.
Deborah Gammill scanned the area for her son, Carter Gammill, a camper with autism at CampLivitUp.
A curly-haired teen, dripping wet from the pool, stopped by briefly.
"It's really cool how they (participants in CampLivitUp) get to interact with our camp as well," said Jacob Klaven, a counselor for the Memphis Jewish Community Center summer camp, which was holding sessions the same day.
CampLivitUp, a seven-week camp conducted by United Cerebral Palsy of the Mid-South, started June 13 and focuses on children and young adults with disabilities such as cerebral palsy, autism and down syndrome.
Camp co-director Cassie Luna explained that other camps for people with disabilities focus on academic skills taught during school year so campers don't lose what they've learned.
"We focus on recreational and social activities, like engaging with others and introducing themselves" to people, said Luna. "Typical kids learn these skills independently."
The camp offers morning and afternoon sessions where 54 campers swim, play sports, and create art projects. Ages range from 5 to 22 years, and groups are divided by age, gender, and ability level.
The camp assigns a volunteer for each camper, and group leaders oversee each group throughout the day.
Camp group leader Rebecca Dupuis supervises a group of girls aged 16 to 19. Some of the girls' daily discussions involve a love for the brooding Prince Caspian in "The Chronicles of Narnia" films and teen heartthrob Justin Bieber.
"It's more relaxed here," said Dupuis. "It's a fun time for them to just have fun at camp."
About two years ago, Dupuis began taking camper Shellie Thomas, 14, for ice cream or a movie about once a week in the afternoon. Shellie, who has developmental delays, has been attending the camp for about five years.
"The main thing that I wanted was for her to have that interaction with a typical peer," said mother Connie Thomas.
Often, group leaders start as volunteers at the camp and work their way up. Some campers are paired with the same staff each year, forming a bond Luna believes campers don't receive in school.
One activity for the older girls involves a karaoke day, where both campers and staff bring their favorite music.
That type of interaction, said Luna, "brings up conversation skills."
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León Hotels
Holiday Inn Leon Convention Center
This facility has earned my loyalty for their uncompromising willingness to help, their innovative...more
NE Hotel Nueva Estancia
This hotel is one block to the Plaza del zapato and Plaza de la piel, but little bit far from...more
Radisson Poliforum Plaza Hotel
Blv Adolfo Lopez Mateos 1611 Ote Col Barrio de Guadalupe, Leon, 37280, Mexico
Satisfaction: Excellent
Good for: Couples
Real De Minas Express Leon
Blvd. A. López Mateos 1902 Ote. El Mirador, Leon, Central Mexico and Gulf Coast, 37270, Mexico
Satisfaction: Very Good
Good for: Solo
Terranova Zona Piel
112 Salina Cruz, Leon, Guanajuato, 37260, Mexico
Satisfaction: Very Good
Good for: Solo
Crowne Plaza Hotel Leon, Gto
Blvd Manuel J. Clouthier 245, Leon, Guanajuato, 37150, Mexico
Satisfaction: Very Good
Good for: Couples
Hotel Mexico Plaza Centro Max
Blvd Adolfo Lopez Mateos 2510, Col Cerrito De Jerez, Leon, 37530, Mexico
Satisfaction: Average
Good for: Families
Holiday Inn Leon Mexico
Blvd Lopez Mateos 1308, Colonia, La Martinica, Leon, Central Mexico and Gulf Coast, 37270, Mexico
Satisfaction: Poor
Good for: Couples
Holiday Inn Leon
Blvd Lopez Mateos 1308, Colonia, La Martinica, Leon, Central Mexico and Gulf Coast, 37270, Mexico
Satisfaction: Poor
Good for: Couples
León Transportation
from Leon Airport (BJX) you can get a Taxi from the Taxi Desk into downtown Leon for apx 200 N-Pesos (apx$20US), or if your on a budget, traveling light & don't mind walking about 200 yards out to the hwy you can catch a bus into downtown for less than a 10N-Peso's ($1US)
just exit out the front of the airport and past the taxis walk west on the airport access street towards the Highway when you get there turn to the right (north) and walk to the bus stop. wait for the local bus it stops along the way into downtown. this take longer than the taxi, but cost 5% of the taxi fee. to get back to the airport by taking the bus back or catch a taxi negotiate the fee to the airport, i usually pay about 100 to 120 N-Pesos ($10 - $12US). i seem the airport taxi desk makes a few bucks of the fees leaving the airport.Related to:
- Budget Travel
I arrived into Leon by Primera Plus bus. It cost about 40pesos to get a taxi ride downtown from the bus station and took about ten minutes. To get to the Leon-Bajio International Airport (BJX) it takes about half an hour by taxi and cost 200 pesos. There are a few food stalls at the airport and a duty free store.Related to:
- Business Travel
- Road Trip
León Hotels36 Hotels in León
León Warnings and Dangers
Be careful and watchful when shopping in la plaza de la piel, don't flash cash in public, take purchases back to hotel instead of carrying around, and watch for other customers as they might be watching your purse.
León Favorites
Favorite thing: Leon is the center for the Leather industry. If you are looking for cowboy boots, shoes, jackets or anything leather, you can find it here. In the area near the convention center and Plaza Zapata, there are hundreds of stores selling leather goods at real low prices.Related to:
- Business Travel
Favorite thing: Here I stand at a nice old car at the hotel entrance. I went to León for a seminar, so I had few time to go to the downtown area.Related to:
- Family Travel
- Business Travel
- Road Trip
Don't Forget Insurance
If your current health insurance doesn't cover you while your abroad, you should consider getting international travel insurance just in case something should go wrong.
Instant Answers: León
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Poems by Lew Welch. This PoetrySoup page contains a list of poems and links to Lew Welch poetry. Comment of this poet below.
Lewis Barrett "Lew" Welch, Jr. (August 16, 1926 – May 1971) was an American poet associated with the Beat generation of poets, artists, and iconoclasts .
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Submit a Lew Welch poem here...


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Non-Military Options in Iraq
The House Armed Services Committee Defense Policy Panel heard testimony on methods to enforce the U.N. resolutions concerning Iraq without… read more
The House Armed Services Committee Defense Policy Panel heard testimony on methods to enforce the U.N. resolutions concerning Iraq without resorting to the use of force by a military power. Issues raised in the hearing including strengthening economic sanctions against Iraq and aiding the democratic opposition in Iraq. The committee also sought to hear information on non-military means of removing Iraqi leader Saddam Hussein from power. close
People in this video
- Patrick Clawson Research Scholar Foreign Policy Research Institute
- Richard W. Murphy Assistant Secretary (Former) Department of State->Bureau of Near Eastern Affairs
- Laurie Mylroie Fellow Harvard University->Center for Middle East Studies
- Les Aspin U.S. Representative [D] Wisconsin
- Charles Bennett U.S. Representative [D] Florida
- Beverly B. Byron U.S. Representative [D] Maryland
- Ronald V. Dellums U.S. Representative [D] California
- Patricia S. Schroeder U.S. Representative [D] Colorado
- Norman Sisisky U.S. Representative [D] Virginia
- Isaac "Ike" Skelton U.S. Representative [D] Missouri
Hosting Organization
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News from WTOP
News from the AP
Mike Causey
Shows & Panels
Shows & Panels
- Agency of the Month
- Business of Government Hour
- The CFO Agenda: Delivering value from financial transparency and audit efforts in the public and private sector
- Cloud-Driven Data Insights in Government
- CXO Surveys
- Disaster Resilience for America
- Federal News Countdown
- Government Perspectives on Mobility and the Cloud
- Reducing Risk in the Cloud
- Reimagining the Next Generation of Government
Shows & Panels
- AFCEA Answers
- American Readiness: Renewable Power and Efficiency Technologies
- Ask the CIO
- The Business Case for Cloud Computing in Government
- Cloud-Driven Data Insights in Government
- Connecting the Dots: Digital Authentication in Government
- Data-Centric Approaches to Government in the Cloud
- Delivering the Digital Government Mission
- Federal Executive Forum
- Federal News Radio's National Cyber Security Awareness Month Special Panel Discussion
- Federal Tech Talk
- The Future of Government Data Centers
- Government Perspectives on Mobility and the Cloud
- Industrialized, Interoperable and Insight-driven Federal Health Panel
- Innovation and Tech Superiority through Acquisition Reform
- Mitigating Insider Threats in Virtual & Cloud Environments
- Moving Agency Applications to the Cloud with PaaS
- Reducing Risk in the Cloud
- Security in the Age of Targeted Attacks
- Air Traffic Management Transformation Report
- The Business of Cloud
- Cloud First Report
- Data Driven Cloud Series
- Disaster Resilience for America
- General Dynamics IT Enterprise Center
- Gov Cloud Minute
- Government in Technology Series
- Homeland Security Cybersecurity Market Report
- The Intersection: Where Technology Meets Transformation
- Modern Mission Critical Series
- National Cybersecurity Awareness Month
- The New IP for Federal IT
- The Social Platform Solution for the Department of Veterans Affairs
- Technology Insights
- The Cyber Security Report
- The Next Generation Cyber Security Experts
Shows & Panels
- Cloud-Driven Data Insights in Government
- Disaster Resilience for America
- F-35 Lightning II Program
- Government Perspectives on Mobility and the Cloud
- On DoD
- Pentagon Solutions
- Reducing Risk in the Cloud
- Reimagining the Next Generation of Government
- Transforming Business Operations at the Defense Department
UK may OK creating babies with DNA from 3 people
Friday - 6/28/2013, 11:08am EDT
AP Medical Writer
LONDON (AP) -- Britain may allow a controversial technique to create babies using DNA from three people, a move that would help couples avoid passing on rare genetic diseases, the country's top medical officer says.
The new techniques help prevent women with faulty mitochondria -- the energy source in a cell -- from passing on to their babies defects that can result in such diseases as muscular dystrophy, epilepsy, heart problems and mental retardation. About one in 200 children is born every year in Britain with a mitochondrial disorder.
For a woman with faulty mitochondria, scientists take only the healthy genetic material from her egg or embryo. They then transfer that into a donor egg or embryo that still has its healthy mitochondria but has had the rest of its key DNA removed. The fertilized embryo is then transferred into the womb of the mother.
Some groups oppose artificial reproduction techniques and believe the destruction of eggs or embryos to be immoral. British tabloids jumped on the procedure when it was first announced in 2008 and labeled it the creation of a three-parent baby -- the mother, the donor and the father -- a charge scientists claim is inaccurate because the amount of DNA from the donor egg is insignificant.
"Scientists have developed ground-breaking new procedures which could stop these diseases being passed on," Britain's chief medical officer, Dr. Sally Davies, said in a statement on Friday. "It's only right that we look to introduce this life-saving treatment as soon as we can."
Similar research is going on in the U.S., where the embryos are not being used to produce children.
Earlier this year, the U.K.'s fertility regulator said it found most people supported the new in vitro fertilization methods after a public consultation that included hearings and written submissions. Critics have previously slammed the methods as unethical and say there are other ways for people with genetic problems to have healthy children, like egg donation or tests to screen out potentially problematic embryos.
In a response to the public consultation, the charity Christian Medical Fellowship said the techniques were unethical. "We do not consider that the hunt for 'therapies' that might prevent a small number of disabled children (with mitochondrial disease) being born justifies the destruction of hundreds if not thousands of embryonic human lives," the group said. It also said there were lingering concerns about the safety of the techniques.
British law forbids altering a human egg or an embryo before transferring it into a woman, so such treatments are currently only allowed for research. The government says it plans to publish draft guidelines later this year before introducing a final version to be debated in the U.K. Parliament next year. Politicians would need to approve the use of the new techniques before patients could be treated.
If British lawmakers agree, the U.K. would become the first country in the world where the technique could be used to create babies. Experts say the procedures would likely only be used in about a dozen women every year.
"Many of these (mitochondrial) conditions are so severe that they are lethal in infancy, creating a lasting impact upon the child's family," said Alistair Kent, director of the charity, Genetic Alliance U.K., in a statement. "An added option for families at risk of having a child with such a condition is welcome."
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Tribal - the global provider of products and services to the international education, training and learning markets – is now distributing that LCMS to its clients.
Whether I'm speaking with marketers, technologists, product management or sales, one topic is constantly top of mind: the importance of understanding and communicating content ROI. And, equally importantly: responding to content ROI quickly, and efficiently.
These days, content is the backbone of online business, impacting customer decision-making before direct contact is made with sales or through marketing automation. As channels proliferate, Enterprises need to ensure that they deliver personalized content that resonates with their diverse audiences, in any context and on any device.
What: Webinar with EMC and Hippo CMS
When: March 26th
Time: 10am PT | 1pm ET | 7pm CET
Sign up here
To ensure that their content is helping reach business goals, enterprises need a smart, third-platform Web Content Management System that uses data and metrics to continuously optimize their content's performance.
Understanding Content Performance helps you personalize the digital experience even at the anonymous visitor. Measuring and understanding which content is being consumed in real time, in combination with contextual data, helps you resonate with your visitor before the email address is captured, earlier in the funnel-- before marketing automation plays a role.
If you are considering a transition to a new content management solution, the addition of a CMS solution to a portal or site or a blog, portal, or site redesign, you may wish to look at Umbraco and consider its open source, flexible features, templates and customization capabilities. It is a worthy contender in the CMS market and offers numerous functional and technical benefits to your business.
MotoCMS is ready for a major update that includes full responsiveness, Media Library and more great features. The great release of the major MotoCMS 3.0 update is coming in a several weeks, but a free beta version is about to be released in just a couple of days.
While SquareSpace and Wordpress battle for the top spot, a new AI website design company could change the way we look at CMS all together.
The main aim of any Magento store owner is to sell his products, and for that just to place them on the pages of your site is not enough. Selling is usually a result of promoting as it is the only way to let customers know about new goods and new brands available at your store. Promotion process can't be chaotic: you need to have a strategy to follow. Amasty Team offers you 5 tips to start with to get your products promoted.
Leading web content management and digital experience platform brings value to customers by creating relevant customer experiences across all channels.
Following a historically successful first quarter, web content management and digital experience software vendor Hippo today announced new subscription-based business in H1 2014, compared to the same period in 2013 accelerated by 164%. With a near 50% subscription revenue growth rate in 2013, Hippo and its vision of truly personalized multichannel digital experiences show no sign of slowing down.
The XOOPS Development Team is pleased to announce the release of XOOPS 2.5.7 Final.


text:
News from WTOP
News from the AP
Mike Causey
Shows & Panels
Shows & Panels
- Agency of the Month
- Business of Government Hour
- The CFO Agenda: Delivering value from financial transparency and audit efforts in the public and private sector
- Cloud-Driven Data Insights in Government
- CXO Surveys
- Disaster Resilience for America
- Federal News Countdown
- Government Perspectives on Mobility and the Cloud
- Reducing Risk in the Cloud
- Reimagining the Next Generation of Government
Shows & Panels
- AFCEA Answers
- American Readiness: Renewable Power and Efficiency Technologies
- Ask the CIO
- The Business Case for Cloud Computing in Government
- Cloud-Driven Data Insights in Government
- Connecting the Dots: Digital Authentication in Government
- Data-Centric Approaches to Government in the Cloud
- Delivering the Digital Government Mission
- Federal Executive Forum
- Federal News Radio's National Cyber Security Awareness Month Special Panel Discussion
- Federal Tech Talk
- The Future of Government Data Centers
- Government Perspectives on Mobility and the Cloud
- Industrialized, Interoperable and Insight-driven Federal Health Panel
- Innovation and Tech Superiority through Acquisition Reform
- Mitigating Insider Threats in Virtual & Cloud Environments
- Moving Agency Applications to the Cloud with PaaS
- Reducing Risk in the Cloud
- Security in the Age of Targeted Attacks
- Air Traffic Management Transformation Report
- The Business of Cloud
- Cloud First Report
- Data Driven Cloud Series
- Disaster Resilience for America
- General Dynamics IT Enterprise Center
- Gov Cloud Minute
- Government in Technology Series
- Homeland Security Cybersecurity Market Report
- The Intersection: Where Technology Meets Transformation
- Modern Mission Critical Series
- National Cybersecurity Awareness Month
- The New IP for Federal IT
- The Social Platform Solution for the Department of Veterans Affairs
- Technology Insights
- The Cyber Security Report
- The Next Generation Cyber Security Experts
Shows & Panels
- Cloud-Driven Data Insights in Government
- Disaster Resilience for America
- F-35 Lightning II Program
- Government Perspectives on Mobility and the Cloud
- On DoD
- Pentagon Solutions
- Reducing Risk in the Cloud
- Reimagining the Next Generation of Government
- Transforming Business Operations at the Defense Department
What 's the impact of USDA's big shrink?
Tuesday - 1/10/2012, 5:23pm EST
The big shrink is on at the Agriculture Department. The department announced plans to close 259 offices, labs and other facilities.
Secretary Tom Vilsack said the Blueprint for Stronger Service is part of a bid to save $150 million from the department's $145 billion budget.
However, critics charge it will have a negative impact on food safety.
Tom Shoop, the editor-in-chief of Government Executive magazine, joined In Depthwith Francis Rose to discuss what the closures might mean both for the agency itself as well as an example to others.
The plan seems to have garnered almost as many questions as answers: How many jobs will be lost? And how will USDA make up for the work done at these facilities?
Click here for a map of proposed USDA office closures.


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Items Tagged with 'Medical Mile'
Institute is building a national footprint through technology
Visit Van Andel Institute on Grand Rapids' Medical Mile and you'll see plenty of evidence of our sense of history. Read More
Corridor draws city planners' attention
Medical Mile's growing pains are at center of proposal.
(As seen on WZZM TV 13) The Michigan Street Corridor has seen $1 billion worth of development in the past decade, and if projections are correct, the area — also known as the Medical Mile — will see millions of dollars more in development over the course of the next decade. Read More
Michigan among least competitive for commercial health insurance
Consumers suffer when the choices are too few.
From the Medical Mile in Grand Rapids to the University of Michigan Health System in Ann Arbor, Michigan offers a number of health care options, yet it is considered one of the top concentrated markets in terms of commercial health insurance. Read More
Developer plans $5.1M project along Medical Mile
A developer is planning a $5.1-million project to add residential and retail space along a key corridor in Grand Rapids. Read More
Expanding research hub will drive region's economy
In 2010, Michigan State University, in a landmark decision, greatly raised the profile of the Medical Mile and Michigan's Life Sciences Corridor with its opening of the College of Human Medicine's Secchia Center across from Van Andel Institute. Read More
Spectrum facility to promote research and program growth
Four new labs will give professionals and students a chance to collaborate.
A refurbished facility on the fringe of downtown will provide biomedical research space for tenants on the Medical Mile. Read More
Collaboration is a biomedical research imperative
When my parents considered building a research institute in Grand Rapids in the late 1990s, many people thought it a foolish endeavor. Read More
University plans downtown expansion on $18.9M land
A university is taking a major step to expand its heath care campus in downtown Grand Rapids. Read More
Is health care construction shifting?
While the Grand Rapids skyline is still dotted with crane booms, the massive tower cranes on the Medical Mile have disappeared. Read More
City OKs second stage of Mid Towne Village
Commissioners revise brownfield plan for hotel and office structure.
A key urban development situated on Michigan Street's Medical Mile received the green light last week to go ahead with its second and final phase. Read More


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1991 Bolla Valpolicella55 Ratings
55 Ratings
1991 Bolla Valpolicella
Wine Details
Winemaker's Notes
(From 2010 Vintage) NOTES: After crushing and destemming the grapes, a cool fermenta-tion took place to retain many of the aromatic fragrances and fruitiness. After alcoholand malolactic fermentation, the wine aged in stainless steel tanks to retain its fruit and crispness. Bolla Valpolicella is ruby-red in color, tending to garnet with aging.
Shipping Information
Free shipping with a purchase of 12 bottles or more.
Free shipping with a purchase of 12 bottles bottles or more.
Expert Reviews
Wine Buyer(From 2005 Vintage) After aging in the finest oak barrels the Bolla Amarone della Valpolicella that emerges is a wine of ruby-red color with a dry, rich, complex flavor.


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Perry Seeks To Win Over Iowa
Rick Perry is working his way through Iowa one handshake, bear hug and backslap at a time. The approach contrasts with his failed presidential bid four years ago.
Perry Touts Texas Record In Iowa Return
Former Gov. Rick Perry touted his record of tax cuts and job creation throughout his time in Texas during a return trip to Iowa on Thursday, at a GOP organization event.
Authorities Place 4 Texas Disabled Men In Protective Care
4 mentally disabled, former employees of Henry's Turkey Service, who were mistreated by the company, have been placed in protective care.
Perry In Iowa Again Courting Voters
Gov. Rick Perry is visiting Iowa for the fourth time in eight months, hoping to win over Republicans who delivered him a caucus loss when he ran for president two years ago.
Texans Still Recovering After "Cruel" Life On Iowa Turkey Farm
There are two special men living in North Texas who now show little sign of the awful things that happened to them for so many years. For decades they, and 30 other Texans like them, called an Iowa schoolhouse home and gutted turkeys for $65 a month.
Cruz Logging Serious Time In Iowa
Sen. Ted Cruz is heading to Iowa on Tuesday. This is his fourth trip there in eight months, logging some serious face-time in the state that kicks off presidential voting.
Perry Avoids 2016 Talk In Iowa
Gov. Rick Perry returned to Iowa for a visit that he said was focused on helping the state's governor seek re-election — and not on a potential 2016 presidential bid of his own.
Perry Plans 2-Day Trip To Iowa
Gov. Rick Perry is returning to Iowa on Thursday for a two-day visit that includes stops in the Des Moines suburbs and a meeting with business leaders in Davenport.
Rising Star: Iowa Forward Jarrod Uthoff
Uthoff has been critical to Iowa's resurgence. The Hawkeyes are 15-3 with road losses to Iowa State and Wisconsin and a neutral court loss to Villanova, none by more than four points.
Hill Leads LSU Past Iowa 21-14 In Outback Bowl
Jeremy Hill rushed for 216 yards and two touchdowns, helping No. 14 LSU and inexperienced quarterback Anthony Jennings hold off Iowa 21-14 in the Outback Bowl on Wednesday.
Perry 2.0 Takes Quieter Approach In Iowa
This time, there were no media throngs or fawning Republicans awaiting his arrival. But Texas Gov. Rick Perry's return to Iowa sounded much like an appeal for a second chance.


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Program of Events
CFBF Home
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We are using two properties that are across the street from each other and each is connected to the Conference Center.
Portola Hotel
2 Portola Plaza
Monterey, CA 93940
Rate: $172 per night
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Monterey, CA 93940
Rate: $175 per night
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Use our online single system reservation site to make a room reservation at either hotel at:
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Suites range from $360 to $800 depending on size and type
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Valet Parking $20 per day
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Valet Parking $24 per day
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Phone: (800) 698-3276, Fax: (916) 561-4507


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DMV to Internet-less New Yorkers: Get in Line
By Jared Chausow
By Katie Toth
By Elizabeth Flock
City Hid Facts From Feds About Rikers
By Albert Samaha
Flood Wall Street Gets Pepper Sprayed and Arrested
By Anna Merlan
By Jon Campbell
Report Sheds Light on Anti-Muslim Bias
By Jon Campbell
Rikers Island Lawsuits Over Diabetic Care
By Albert Samaha
"We're an actual band," he went on, all blasé and shit, "not one of those simulated bands playing in the pit. We play loud! Some of us have former drug problems. That's a joke, but you can print it. No, that's not a joke, but you can print it." Got it, it's printed. But what was the band's low point, the kind of moment that would really make you want to reach for the bong? "We once played a punk-rock club in Pittsburgh," obliged Stew, "that turned out to be an AA meeting." Wait, no open bar? "Yeah, that was the problem!" he said, laughing. And now . . . the big oy vey meeting known as Broadway! Come on, Stew, aren't you shitting yourself? "I haven't liked any musical since Hair," answered the Out 100 honoree, unfazed. "I did not like Rent, I'm sorry. It didn't sound like rock music to me. I think we're the first rock musical because we're a rock band!" Yeah, an actual one!
On dry land, an all-black Cat on a Hot Tin Roof is heading to Broadway, and it's neither passing nor strange. But this production recalls the monochromatic revamp of Hello Dolly! starring Pearl Bailey in the '60s, when the concept made sense as more of a jolting novelty. Besides, that show wasn't about people owning a plantation. Maybe this will be a Twilight Zone reversal in which blacks reclaim the old South they deserve. Whatever the case, objections dissolve when greeted with the cast, which includes biggies like James Earl Jones, Phylicia Rashad, and Terrence Howard (as the gay on the down-low). These people can play whatever the fuck they want.
At a recent promotional panel I went to, director Debbie Allen was asked why they're doing an all-black Cat, but she dodged the question the way she avoided Leroy's machinations on Fame. (Y'all remember Fame, right? Show of hands.) "I'm a big fan of Tennessee Williams," Allen cooed. "He's one of the most glorious writers to come out of the American diaspora." Pause. "Honey, he's from Mississippithey all got a touch!" And you can print that, honey.
A reporter noted that in the 1974 revival that came out of the American diaspora, they had two Negro servants. "We still have Negro servants!" said Allen, cracking up. Serving some zingy self-assurance, Anika Noni Rose was asked how she feels about doing the Liz Taylor role and she replied, "I'm gonna do the Anika Noni Rose role!" And when another reporter wondered if the cast feels pressure about having a hit, Phylicia Rashad (doing the you-know-who role) mesmerizingly responded, "We don't think about that! Theater is about disciplinethe discipline of having your entire instrument available at every moment." James Earl Jones perked up right then and gurgled, "I liked that answer so much I've got to hear the question again!"
William Inge's own prize domestic drama, Come Back Little Sheba, is also coming back with an African-American touch, thanks to star S. Epatha Merkerson (or just S, as I call her; yes, we're that close). I recently asked S what Sheba, the lost dog on a hot tin roof, represents. "Sheba represents Lola's happiness, her youth, all of that," she responded as I wittily retorted: "Now I know how Ellen DeGeneres feels!"
The whitest show on earth, Young Frankenstein, was the subject of a New York Times Arts & Leisure Week panel, in which Mel Brooks and company bizarrely went into 90 minutes of detail about how they created a musical the Times loathed. This was the most ironic theater event until Rent couldn't afford to renew its lease. "Why don't you say anything nice about Young Frankenstein?" an agonized Mel asked the moderator, Times reporter Campbell Robertson (who didn't want to hear the question again). "I'm not Ben Brantley!" reminded Robertson, smilingly squirming. "Holy shit!" said Mel, faking surprise. The audience laughed, then prepared for more of Mel's relentless defense strategy. "Look, critics want to support a green caterpillar inching towards the sun," said the irascible old Jew. "They want to play God. But we're a butterfly!" And a fairly mediocre one, though quite funny in spots. The lovable egomaniac went on to wildly overpraise his stars and to interject self-adoring things like how an arrangement of one of his songs made him cry, but I was relieved to learn he's an equal-opportunity offender. "The Post is a piece of crap too," he conceded, "but the Times at least puts up a nice appearance."
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Question for Kevlar users
View Single Post
Join Date: Dec 2011
Posts: 225
That is impressive; I really wish I would have played tennis seriously in my younger years to get to that level of play. I fell for golf instead.
The 4.0 guys around here seem to be mostly true 4.0s, but the 4.5s start to be previous (and even some current) college players who are tall and have massive angle advantages over my 5'8" self + years and years of experience with the sport.
I've been playing about 16 months, and my goal was to play quality 4.5 by the end of this year but did not make it. Ultimate goal for myself is to play 5.0, but I have 4 daughters (ages 2, 3.5, 5, 6.5 - 2 lefties and 2 righties); and the the oldest is starting to enjoy tennis. They are at the courts with my wife and I for 10 hours a week; so my efforts, research, and time is being passed on to them.
Your reply reminded me that I really need to get another video recorder that I can set up on a tripod to record myself at the courts.
Originally Posted by
Tough question since guys who are by definition 6.0 play 5.0 USTA leagues here.
I played two seasons of 5.0 and there were guys in there who recently graduated DI All Ivy or had ATP points in the past.
Got bumped down to 4.5 from playing injured (stupid pride), but will likely go back up to 5.0 after this season if I play singles.
I have been as high as #3 in Eastern men's open, 100 something national men's open despite my generally crappy showing in tournaments.
I am more of a practice court hero than match player, I can practice with anyone up to low level ATP guys.
There are a couple videos of me floating around, I will try to take another one in the next couple of weeks if my illegitimate brother/son gets over his hangover.
RACQUETS: Vantage 95 (Strung: 11.5 oz, 5HL, 67ra, 16x19, 26.5")
CURRENT STRING: Genesis BM 16 @ 56lbs Mains / OGSM (natural) 17 @ 60lbs Crosses
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Search teams on bikes reach areas smashed by 'Yolanda'
More News from Kristine Angeli Sabillo
More News from INQUIRER.net
MANILA, Philippines – With many roads still blocked by fallen trees or debris, Interior Secretary Manuel "Mar" Roxas II on Monday said they used bicycles to reach isolated areas affected by monster typhoon "Yolanda."
"Nagpapadala kami ng tao, nakabisikleta (We've been sending a person on bicycle)" who acts as a scout, he said in an interview with Radyo Inquirer 990AM.
Roxas said they tell the person to relay messages to the isolated communities and to gather information on their situation.
"Ngayon unti-unti pa lang pumapasok, bumabalik yung mga scout. At hindi maganda yung balita, lalong nakakalungkot. (Now the scouts are starting to return. And the news they bring is not good. It is saddening)," he said.
He said it has been very difficult for them to facilitate relief operations because of the lack of communication link. For the last three days, communication lines and electricity were down in typhoon-hit provinces of Samar and Leyte.
Earlier reports said Roxas and Defense Secretary Voltaire Gazmin were incommunicado for several hours on Friday after "Yolanda" smashed Visayas and other parts of the country. A satellite phone had to be sent to them since even radio tranceivers were deemed useless.
Read: Zamboanga crisis veterans Roxas, Gazmin no match for 'Yolanda'
On Monday, reports filtered in that cellular services were restored in the city. Some roads were also being cleared.
"There is no AM radio. We can't even broadcast to tell the people to proceed to the barangay (village) hall for the distribution of relief goods," added Roxas, who was earlier sent by President Benigno Aquino III to oversee disaster preparations in the region.
The Interior Secretary said their movements have been limited, even inside Tacloban City where he is currently stationed, because many of the roads were blocked.
Days after the calamity, relief goods had to be flown into the city proper because roads from and going to Tacloban airport were blocked. Palace officials said they have also been airdropping relief goods to areas not reachable by land.
With only a small portion of the affected areas surveyed, authorities and humanitarian aid groups fear the full extent of damage wrought by the typhoon on Eastern Visayas.
Roxas said that for now they are focusing on the basic needs of the survivors, followed by the restoration of order and the recovery of corpses.
The Secretary said the national government has stepped in because many of those in the local government units were also devastated by what is now considered among the world's strongest typhoons.
"There are 293 policemen in Tacloban. (After the typhoon) only 20 reported. Others died, were wounded or are still looking for their relatives," Roxas revealed.
He said government forces from other regions were sent to the area to help restore peace and order amid news of looting.
Roxas called on the public and concerned groups to forward their donations to the Department of Social Welfare and Development. He also urged engineers and medical personnel to volunteer. He, however, added that the typhoon-hit provinces are in dire need of medical supplies, as well as operators and equipment used for clearing operations.
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Daughter's last words: 'Ma, just let go… Save yourself'
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Japan to fly medical team to Philippines
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DC Riji Snowboard Jacket - Women's
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A long fit jacket, the riji 13 is finished off with an elastic hem finish for a unique look. If there were a boyfriend fit for jackets, this would be it!
Key Features of the DC Riji Snowboard Jacket:
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- Inside mesh stash pocket
This product can only be shipped within the United States. Please don't hate us.


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Emilio Rojas ft. B.o.B. & Leo - Tell No Lies
Artist: Emilio Rojas
Featuring: B.o.B
Producer: DJ Green Lantern & V12 The Hitman
Album: Life Without Shame
Avg Rating: 3.9 ( 19 votes )
In an age where rappers shamelessly flaunt their material wealth, DJBooth Freestyle Alum Emilio Rojas is very frank about his less-than-ideal financial standing on Tell No Lies, a new single from his latest mixtape, Life Without Shame. Let's be real –the majority of us can relate to a song about spending more than you make, or being late on the rent, more than songs about popping bottles and flying in G6 jets (whether we want to admit it or not). Tell No Lies falls perfectly in line with the idea behind the title as we get Emilio Rojas delivering verses over a DJ Green Lantern and V12 The Hitman produced beat, delving into his money woes with a sincere conviction: "My shorty wakin' up hungover. It's funny, because this champagne lifestyle is sobering." For guests, B.o.B comes through with an equally sincere verse that that echoes Rojas' frustrations – "Folks tellin' me I made it. Please, I ain't made sh*t, my soul still need saving" – while newcomer Leo jumps in with a distinctive hook. And what better way to save your soul than to admit to the world (and yourself) when you're not at your best?
Written by Stephanie Vaughn on Nov 23, 2010
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