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In an exclusive interview Wednesday afternoon at his basketball camp, Grizzlies free agent Mike Miller opened up about his future and where he might play next season.
92.9: Where do things stand right now with you?
Miller: "I'm just in a holding pattern like everyone else, waiting to see what the big fella (Lebron James) does. Obviously, everyone knows my intentions are with Memphis and how we wanna make it work. But if it doesn't, I'll have to figure out where the next stop is for me."
92.9: Is your first choice still to stay in Memphis?
Miller: "It is. I hope it works out. At the same time, I understand business. The one thing I've learned in 14 years of playing — I've been traded 6,000 times, I've been amnestied. I understand that side of it. I get it. For me, I wanna be here, but at some point for the basketball side and business and for me personally, I'm gonna take what's out there."
92.9: Have you spoken to the Grizzlies recently? If so, did it get down to renegotiations?
Miller: "We did two or three days ago. And not really. They're waiting to see. ... I've got everything on hold just to see what Lebron does. I'd be crazy not to at least wait now that we're this far along. I'm hoping he makes a decision this week, either today or tomorrow. Once I have that, I'll start getting into discussions with other teams. If Memphis works out, great. If it doesn't, I'm still gonna play basketball next season."
92.9: Is reuniting with Lebron something you'd like to do?
Miller: "Oh, of course. It makes my job easier. I just go out there and shoot jumpers. It's pretty easy. For me, that'd be a dream come true. At the same time, and I've had this convo with Lebron, for my family and things like that — Memphis is the best place. But I've prepared my wife and kids to move on and we'll see what happens."
92.9: Any more visits planned?
Miller: "No, I don't need to. I basically know where every team's at and what they're gonna offer. We decided to wait and see what Lebron does. After he makes his decision, it could be either a good place for me to go with him if he does move on, or it opens up teams making cap space for him. The market has been set for shooters. I'm not asking to get what (Lebron and company) are getting, but I am asking for something that's fair for both sides."
92.9: What would it take for the Grizzlies to keep you?
Miller: "For me, I really believe I can be a big part. I look at everything — you look at where you're sitting in a situation, your rotations, what you need to win games in the playoffs. I think I bring a lot to that. And two or three years after, I'm bringing a lot more than just basketball to the situation. I don't wanna say there's a number, but I think the market has been set for shooters."


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Cardboard diet posts are actually scheduled for Thursdays, but there was a zero percent chance that I was going to blog yesterday. So Friday it is! I hope you all had a lovely 4th. We did! We went to the beach, watched fireworks, and ate. On that note…
If you missed my CBDiet post last week, head over to our wonderful hostess' blog for the details. Feel free to play along. (I use the term "play' VERY loosely.) And should you choose to participate, FOR THE LOVE OF PETE, give Miss Lauren some credit.
Well I haven't weighed myself in quite some time. I've never really believed in scales. I think they are jerks, misleading, and only tell half of the story. Although I did weigh myself at the gym on Sunday. It gave me two different weights. See why I don't trust scales?! But I will weigh myself at home tonight and then next Thursday to see if my scale will tell me the truth. Though I quite relate to Lauren on this. My weight fluctuates day to day, so even if the scale tells me I'm a pound or two lighter, that doesn't actually mean anything at all. Regardless, I'll start tracking. I'll do it for Lauren.
Exercise completed
Okay, NO JUDGING. Remember that I have not stepped foot into a gym since college. That's five years for those of you keeping track at home. I've done some Shred or Biggest Loser Yoga here and there, but I don't really work out. I went to the gym with Stephen and I speed walked (is that a word) for about 3.5 miles. THAT IS A LOT FOR CHELSEA. I did the incline until I thought my butt was going to fall off. While some of you may be thrilled if your butt fell off, I would not be. I don't have much butt to spare. That's all I did. But in ChelseaWorld, that is a success.
Splurge/Guilty Pleasure
My life is a splurge. I only decided on Sunday that I was going to participate, and I didn't do too well. It was holiday week, okay?
Plus, how can you have lunch at work without cookies or fruit snacks for dessert? Maybe that's my problem. Hmm. Also, I have a new love for Shock Top Raspberry Wheat beer. (Last week, Lauren and I both blogged about it… we never even discussed our love in real life. That's how you know we are blog soulmates.)
Success Story
You did hear me say that I went to the gym, right?
Sweet Potato Fries! Not really a recipe, just instructions. Skin your sweet potatoes and cut them up into fries. I've heard that soaking them in water for a few hours helps them crisp up so I always do that. Toss them with some cornstarch and then coat them in olive oil. Lay them on a well oiled cookie sheet (don't crowd them) and sprinkle them with garlic salt. Bake in a 400 degree oven, flip after about ten minutes and then cook them a bit longer. Excellent!
I didn't take photos of my food or fitness. I'll work on that.

subset: commoncrawl


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Speakers Corner
It's free to register, to post a question or to start / join a discussion
Wrong kind of weather
Likes # 0
Posted May 9, 2011 at 11:57AM
It seems the perennial energy argy-bargy is flaring again. Now one contributing excuse appears to be "Consumers are not consuming enough, so we may have to hike the prices"
Likes # 0
Posted May 9, 2011 at 12:57PM
Grey Goo
It's all about supply and demand. Centrica will supply gas and demand as much money as they can.
Likes # 0
Posted May 9, 2011 at 12:57PM
Grey Goo
It's all about supply and demand. Centrica will supply gas and demand as much money as they can.
Likes # 0
Posted May 9, 2011 at 1:28PM
no jobs available! Tax Tax Tax then every year new ones appear expense of living then the fuel prices food prices energy prices!!
this country is becoming or has become almost in an unacceptable state if your out of work!
We are seriously thinking of moving abroad my wife's uncle is the principle in one of the biggest universitys in the country we may be going to & my wife has a teaching degree so she is guaranteed a job over there whereas he its all red tape & not enough jobs!
Great Britain..Yeah right!
Likes # 0
Posted May 9, 2011 at 2:00PM
Its really heart-warming to hear our regulators and watchdogs come out with some fine statements, then do very little to justify their existence in the roles they are suppose to play.
I was watching a television program yesterday, which was discussing commodity brokers and how some farmers are having to be very innovative in negotiating crop prices 3 years ahead. What stocks are being withheld, are there for the 'rainy day' fund!.
But gas and electricity price rises are just becoming a total excuse for greed on the behalf of the suppliers. There is suppose to be competition out there, but you tell me where it is?.
Likes # 0
Posted May 9, 2011 at 10:47PM
It's my fault. Because of the high cost of gas and electric I have reduced how much I use.
I will send a letter to BG explaining this and if they keep putting up the price I will stop altogether and go and live in a tent like Gaddaffi.
If they do listen we may see a small reduction in our bills.
I will let you all know if they give me a reduction.
Likes # 0
Posted May 9, 2011 at 11:24PM
peter99co If you have a garden you could get one of these domestic Wind Turbines and be self-sufficient
Likes # 0
Posted May 10, 2011 at 8:06AM
If they do listen we may see a small reduction in our bills
I applaud your optimism!
Likes # 0
Posted May 10, 2011 at 1:04PM
Don't ask for to much, BG did bring its customer call centres back to the UK, as have other utility companies :O)
Likes # 0
Posted May 10, 2011 at 2:11PM
spuds did they bring the staff over as well?
Likes # 0
Posted May 10, 2011 at 2:14PM
I do have a garden and a wind generator. I also use solar panels on the caravan.
I can resort to a Kelly Kettle to do a mashing of tea if I want.
I feel for those who are not so self suffient and have to do without to pay their energy bills.
I will survive because I have been able to cut back energy use.
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Trying to figure out how to move the revslider text.
This is what I thought I needed to change but it's not working. Trying to get the right side text to move over to the left a bit.
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Edited by travistsickle, 02 May 2014 - 03:36 AM.


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This space was inspired by celebrity designer Nate Berkus' Chicago apartment.
Layering antique furniture with soft shades of lilac, this room is an elegant and upscale take on holiday dining. There's no ornamentation here; a garland of magnolia leaves decorating the 19th-century Dominican sideboard, potted paperwhites and a single vase of hydrangeas, lilies and berries offers subtle nods to the season.
Find more inspiration in our photo galleries of Thanksgiving Tables and Holiday Tables, plus see more holiday decorating ideas in our photo galleries of Christmas Decorating and Designers' Holiday Decorating Tips.
Comment Guidelines
We welcome your feedback on Houseandhome.com. H&H reserves the right to remove any unsuitable personal remarks made about the bloggers, hosts, homeowners and/or guests we feature. Please keep your comments focused on decorating, design, cooking and other lifestyle topics. Adopt a tone you would be willing to use in person and do not make slanderous remarks or use denigrating language. If you see a comment that you believe violates any of the guidelines outlined above, please click "Flag as inappropriate." Thank you.


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As Desbarats points out – "Do not be fooled into thinking you can't make a difference. The consumer choices we make every day are the main driving force behind corporate behavior. Change our buying habits and you change corporate behavior, for better or worse."
If you want to learn more about organic clothing you can visit Desbarats' blog at http://www.blog.fashionandearth.com.
# # #
Read the full story at http://www.prweb.com/releases/2010/06/prweb4122554.htm.
|Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved


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The entire Japan Leadership Development ministry is funded through special projects. Gifts to General Support go towards such items as travel, director's stipend, office expenses, translators, school subsidies and administration.
The My Father's House Orphan Homes create a family style home for a widow and eight orphans. The home is not an orphanage; it is truly a place where the children and their "mama" create a new family, a place they will forever call home. We are in need of renovating all 11 of our homes. The cost for a full renovation of one home is $11,000. A minimum donation of $100 is appreciated!
This "business-as-missions" project of Every Orphan's Hope will expand current poultry farm operations from 24,500 chickens per year to 49,000 chickens per year. The funds will go toward the building of another 3,500 sq. ft. chicken run, storage facility, and the first round of 3,500 chicks, feed, immunizations, and bedding for the initial start-up. The Chick-4-Orphans project provides income to help sustain ministry operations in Zambia and also is used as a training facility to teach small commercial poultry farming to the orphans in our care. A donation of any amount is appreciated!
To an orphan who has lost everything, Camp Hope brings hope and healing. This 5-day Bible camp allows the ministry of Every Orphan's Hope to minister to orphans through Bible study, prayer, music, crafts, and games. Every child receives a Camp Hope T-shirt, bandana, and they are served two to three meals a day, something many orphans rarely experience. Most importantly, they receive a clear presentation of the Good News of Jesus Christ. We're praying for 300 orphans to experience the Love of Jesus at Camp Hope in 2015. Funds need to be received no later than June 1, 2015. A Donation of $40 Sends 1 Orphan to Camp!
Extreme poverty among a minority ethnic group in East Asia makes basic education unaffordable. This fund will support one widow raising four children so they will not be forced to withdraw from school. Our staff will continue ministering to this minority group while ensuring that your gifts meet this foundational need.
Annual Goal: USD 2,700
Talking face to face with ministry partners from other nations around the world provides unique perspectives and insights into ministry needs and opportunities. Making friends with international partners expands our hearts and minds for the world. This July, the North American Baptist Conference is planning to bring six international ministry partners to the 2015 Triennial Conference in Sacramento, giving all who attend an opportunity to personally connect with these special people.
In September 2011, Tony Dunaway (NAB CFO) visited Haiti with the purpose of identifying partners through whom NAB would distribute relief funds. God placed in Tony's heart (and reaffirmed many times) a desire and passion to serve the fatherless. A few months ago Tony began talking with the CEO of Every Orphan's Hope (EOH), an organization that is called to address the overwhelming impact of the HIV/AIDS pandemic on the lives of orphans who have lost everything.
Jozsef Csuhai is a national missionary working in Hungary with NAB missionaries Ron and Jeannie Seck.
Eszter Csuhai is a national missionary working in Hungary with NAB missionaries Ron and Jeannie Seck.
László Daróczi is a national missionary working in Hungary with NAB missionaries Ron and Jeannie Seck.


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Lawn Care
Your lawn can be a source of pride, a place for your family to play, an oasis for relaxing -- and you can make your lawn lush and beautiful with a few simple actions and regular yard care. Of course, mowing is one of the most important things we do to our lawns; if you mow yourself, you can make it easier by using our guide to choosing the best mower for your landscape. If you don't have time to care for your lawn -- or if you're going to be away -- you'll love this advice for choosing a reliable lawn service. In addition, how you care for your lawn depends on where you live; use our regional lawn care tips (and drought-survival tips) for keeping your grass healthy. In autumn, your lawn is transitioning from its active growing season to a dormant period; autumn is a good time to spruce up your lawn with our easy guide. At any time of the year, your lawn might need a little extra care; you can renovate your lawn step-by-step, or follow our 12-week plan. If going green means more than just the color of the lawn, you'll appreciate these environmentally friendly tips that keep your lawn healthy.
plant quick find clear
Have the Best Lawn on the Block
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Keep your lawn healthy even in drought conditions. Watering less means you'll also mow less.
Enjoy a Dog-Friendly Lawn
Can you have a gorgeous lawn AND a dog? Here are six tips to making your lawn Fido-friendly.
Expert Advice: Lawns
Create the lawn of your dreams. Get advice from our turf experts.
Fall Lawn-Care Secrets
Autumn is an ideal time for lawn upgrades. Check out our easy tips.
Find the Best Lawn Mower for You
Choosing the best mower for your landscape means a better-looking lawn. Our guide helps you shop.
Lawn Care 101
Enjoy a lavish lawn by following the simple advice of our lawn guide.
Lawn Care Made Simple
No time? No money? No problem. Lawn care has never been simpler.
Lawn Fertilizer Calculator
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Lay a Sod Lawn
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Organic Lawn-Care Basics
Get a chemical-free (and green!) lawn that's easy and environmentally friendly.
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Fix a brown hole or patch a bare spot. Repairing spots in your lawn is easy.
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Adding top dressing feeds your lawn. Use our calculator to apply the right amount.
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Easy to use and great for the environment, reel mowers are ideal for small-space yards.
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Lawn-Care Calendar for Southern California
Get a happy, healthy lawn by following these tips for your region.
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Lawn-Care Calendar for the Midwest
Midwesterners love their lawns! Here's the best schedule for keeping things green.
Lawn-Care Calendar for the Northeast
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Lawn-Care Calendar for the South
The right grasses and the right care will yield a beautiful Southern lawn.
Pacific Northwest Lawn-Care Calendar and Lawn Maintenance Tips
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Southwest Lawn-Care Calendar
Desert dwellers know the challenge of a lawn. Discover the tips and techniques specifically for hot and dry areas.
Grass Seed
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Picking the Right Grass
The right grass makes all the difference in your lawn. Discover the best varieties for your soil and climate.
Start a Lawn from Seed
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Start a Lawn with Plugs & Sprigs
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Conflict quinoa
- By Joshua Keating
Joshua Keating is associate editor at Foreign Policy and the editor of the Passport blog. He has worked as a researcher, editorial assistant, and deputy Web editor since joining the FP staff in 2007. In addition to being featured in Foreign Policy, his writing has been published by the Washington Post, Newsweek International, Radio Prague, the Center for Defense Information, and Romania's Adevarul newspaper. He has appeared as a commentator on CNN International, C-Span, ABC News, Al Jazeera, NPR, BBC radio, and others. A native of Brooklyn, New York, he studied comparative politics at Oberlin College.
Via Tyler Cowen's excellent new food-only Twitter feed, an AP story of economic scarcity, climate change, conflict, and the favorite superfood of American yuppies:
Bolivian authorities say at least 30 people have been injured in a fight between two communities over land for growing quinoa, the Andean "supergrain" whose popularity with worldwide foodies has caused its price to soar.
Oruro state police chief Ramon Sepulveda says combatants used rocks and dynamite against each other Wednesday and Thursday. A government commission was dispatched to the two high plains communities south of La Paz.
Farmland in the region is owned not by individuals but communities.
Authorities say the dispute is related to climate change because quinoa can now be cultivated in areas previously subject to frequents frosts. Bolivia produces 46 percent of the world's quinoa, which has nearly tripled in price in the past five years.
For the "How Food Explains the World" package for the last May/June issue, I looked at how quinoa's international popularity has effected eating habits in Bolivia. Prices have skyrocketed thanks to export demand and domestic consumption of the nutritious grain has fallen by more than a third, prompting fears of an obesity epidemic as Bolivians switch to rice and white bread. President Evo Morales' government subsidizes quinoa as a "strategic foodstuff."
Related Stories
How to fight the next African famineColum Lynch
Colum Lynch is Foreign Policy's award-winning U.N.-based senior diplomatic reporter. Lynch previously wrote Foreign Policy's Turtle Bay blog, for which he was awarded the 2011 National Magazine Award for best reporting in digital media. He is also a recipient of the 2013 Elizabeth Neuffer Memorial Silver Prize for his coverage of the United Nations.
Before moving to Foreign Policy, Lynch reported on diplomacy and national security for the Washington Post for more than a decade. As the Washington Post's United Nations reporter, Lynch had been involved in the paper's diplomatic coverage of crises in Afghanistan, Iraq, Lebanon, Sudan, and Somalia, as well as the nuclear standoffs with Iran and North Korea. He also played a key part in the Post's diplomatic reporting on the Iraq war, the International Criminal Court, the spread of weapons of mass destruction, and U.S. counterterrorism strategy. Lynch's enterprise reporting has explored the underside of international diplomacy. His investigations have uncovered a U.S. spying operation in Iraq, Dick Cheney's former company's financial links to Saddam Hussein, and documented numerous sexual misconduct and corruption scandals.
Lynch has appeared frequently on the Lehrer News Hour, MSNBC, NPR radio, and the BBC. He has also moderated public discussions on foreign policy, including interviews with Susan E. Rice, the U.S. National Security Advisor, Gerard Araud, France's U.N. ambassador, and other senior diplomatic leaders.
Born in Los Angeles, California, Lynch received a bachelor's degree from the University of California, Berkeley, in 1985 and a master's degree from Columbia University's Graduate School of Journalism in 1987. He previously worked for the Boston Globe.| Turtle Bay |
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Water WarsShane Harris
Shane Harris is a senior staff writer at Foreign Policy, covering intelligence and cyber security. He is the author of The Watchers: The Rise of America's Surveillance State, which chronicles the creation of a vast national security apparatus and the rise of surveillance in America. The Watchers won the New York Public Library's Helen Bernstein Book Award for Excellence in Journalism, and the Economist named it one of the best books of 2010. Shane is the winner of the Gerald R. Ford Prize for Distinguished Reporting on National Defense. He has four times been named a finalist for the Livingston Awards for Young Journalists, which honor the best journalists in America under the age of 35. Prior to joining Foreign Policy, he was the senior writer for The Washingtonian and a staff correspondent at National Journal.| Report |


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Online edition of India's National Newspaper
Tuesday, Sep 06, 2005
Front Page |
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Staff Correspondent
NATURE'S BOUNTY: A view of the Alamatti Dam, where water-level is about 10 cm short of reaching the full reservoir level.
BIJAPUR: Alamatti Dam is almost full even as controversy is raging whether to comply with the Centre's directive asking the State to limit the water level in the reservoir to 509 metres till the month end.
On Monday, the water level reached 519.5 metres as against the full reservoir level of 519.6 metres. It is the highest level of storage this rainy season. Water level reached 519.38 metres in the first week of August but was reduced to 515.8 metres after floods.
As only 10 centimetres is left to reach the brim level, the dam authorities decided to maintain balance between inflow and outflow. The inflow was 31,400 cusecs on Monday. The discharge, which was 12,300 cusecs in the morning, was raised to 31,400 cusecs in the afternoon.
Sources told The Hindu that the discharge is being done not through the crest gates but through hydroelectric plant (Alamatti Dam Powerhouse). Four of the six units have now started generating power, which helped reduce the pressure on Raichur Thermal Power Station. About 46,000 cusecs discharge is required to run all six units at optimum capacity of 290 MW.
According to sources, there is no proposal to reduce the water level notwithstanding the Centre's letter to this effect. The present water level will be maintained as the monsoon is over in the Western Ghat section. If water level is reduced, there is no guarantee of enough inflow to fill the dam, and it will jeopardise water supply to command area of over five lakh hectares under the Upper Krishna Project, they added.
If the water level is reduced to 509 metres as directed by the Centre at the behest of Maharashtra, the storage will dip to 25.3 tmcft from the present quantum (storage) of 121 tmcft that includes 15 tmcft of dead storage. Reservoir holds major portion of the storage of 123 tmcft only above 516 metres level, they said.
Moreover, sources said Maharashtra's apprehension that the Alamatti Dam, when full, causes floods in its territory is totally unfounded. It is illogical to make such allegation as the full reservoir level (519.6 metres) is far bellow the elevation of the Krishna riverbed on the Maharashtra-Karnataka border.
The Narayanpur Dam is almost full. Water level touched 492.03 metres as against the full reservoir level of 492.252 metres.
The live storage stands at a little over 25 tmcft.
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Join me on my journey to lose weight with Weight Watchers and get healthy after 50! What else can I do!
Saturday, 9 August 2014
Weekly Weigh In and Lesson Learned
Two weeks ago I was down 1.1 lbs. Today I was up the 1.1 lbs. I was on a roll but ended up making some horrible choices this week. My dad became ill and had to be hospitalized. As you know, I am not good at dealing with stress and food. He is feeling better. I was thrown right out of my routine. I really have to work on dealing with this because let's face it, life happens.
One good thing did come out of this week. I realized (even though I should have know before) how badly some food choices affect the way you feel. On Thursday I had more bread than I have had in a long time. Before we left for the hospital I had 2 (yes 2) pieces of toast and a boiled egg and 2 cups of coffee. For mid morning coffee we also had a cookie. At lunch, we ended up at a diner and we had chicken salad sandwiches (yes, 2 more pieces of bread) and onion rings, along with another 2 cups of coffee. My dinner was not much better. Not only was I coffeed out, but I felt absolutely horrible and bloated by the end of the day. There is no way I want to feel like this again.
So, Friday morning before I went to the hospital I made the time to workout to the Ripped in 30 DVD and I prepared my food for the day. One of my new favourite breakfasts is peameal bacon (Canadian bacon) with blueberries. The bacon is lean and is 1 WW points plus each. Also, I prepared food to bring to the hospital because I knew the cafeteria would not offer many healthy choices. I brought a boiled egg, fresh cucumbers and a peach. When my mom and I went down for lunch, I just ended up buying a coffee. She was so worried that I would not have enough. I felt so much better than the day before. On the way home, I picked up Swiss Chalet quarter white chicken and salad. All in all, I learned a lesson this week. I just have to remember how horrible I felt and make better choices.
This summer I have not posted any of my garden updates I'm sure you have really missed them :-)
Our tomatoes and cucumbers have been really pitiful this year. They are barely growing at all. However, I did manage to pick some beans the other day. Not a lot but enough for us.
9 comments:
You know what's so wonderful about this post?? Your awareness! You have the presence of mind to identify the physical and emotional reactions you're experiencing. I don't know about you--but in my past, I would get so lost in the fog it just became the norm to feel that way--and to eat under stress and emotionally trying times...
The ability to step outside of this and look at it from the perspective you're choosing is big time, Katrin.
Great pics!!! Fabulous post. Because we can't adjust our approach if we don't honestly assess where we are...You're very in-tune with where you are. :)Replies
Sean, I completely understand the "fog". It really is not a good feeling. Feeling in somewhat control really gives me clarity. Thanks for the encouragement!Delete
Katrin, I'm proud of you. You DID exert great self awareness, and I know you are a better woman today because of it. Love you!ReplyDelete
Sorry to hear your dad has not been well, hope he continues to recover and get well soon.ReplyDelete
Good for you preparing and taking in your own food, it certainly does help.
I love home grown beans......
All the best Jan
Katrin I hope your dad will be OK. I know how hard it can be to make healthy choices when under stress, but you're aware of it and can use this opportunity to refocus on making the best choices for your own health. All the best to you. :)ReplyDelete
Sorry to hear about your dad, I hope his recovery is fast. It's great that you understood what works for you and what doesn't that way you will always be able to make better choices in the future.ReplyDelete
How To Create Mouth Watering Paleo Meals From Scratch in 20 Minutes Or Less By Following A Step-By-Step Cooking Masterclass That Will Make You Look ...ReplyDelete
Amazingly, in this part, you will discover Becky's 10 Old School New Body Transformation tips to lose fat.ReplyDelete
As I've been dealing with my younger brother's hospitalization this past two weeks, I have definitely understood my pull towards emotional eating. It's tough! You just gotta stay strong.ReplyDelete
Hope your father makes a speedy recovery x


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MVWC400XW2 approx 2.5 years old.
Has gradually been getting louder on spin and agitate, makes a creaking noise.
Tilted her up, noticed oil spots on floor, oil is dripping from transmission.
Hopefully creaking noise is oily belt slipping, not a bearing or something.
Is the W10330039 the latest replacement transmission?
It is pricey, is it possible to replace just the seal?
Anyone have the part number for a seal, and other information such as how to add oil, what type, etc?


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Friday, April 27, 2012
Curse of Inge
Posted by Tim Chilcote at 11:02 AM No comments:
Sunday, April 22, 2012
The Crabster: Hard Apple Cider from Northern Michigan
Next time you're in a crabby mood, Tandem Ciders in Suttons Bay, Michigan has the cure: The Crabster, a handcrafted hard apple cider that is at once surprisingly smooth and tart. It's made with nine dessert apples for a refreshing taste, and there's an earthy element from—I'm guessing—an added selection of wild crab apples from the Leelanau peninsula. I don't typically drink ciders because they seem a bit too much like liquid candy, but the Crabster had some wooden flavors that knocked down the sweetness. I need to get up north and score a case for summer porch drinking. In the meantime, short of driving to Suttons Bay, I believe Siciliano's Market in Grand Rapids is the only place in Michigan selling the Crabster. Thanks to my friend Chris Siciliano for hand-delivering a bottle. Read his review of Tandem Ciders at the Buzz: Siciliano's Market News & Notes.
Posted by Tim Chilcote at 2:10 PM No comments:
Tuesday, April 17, 2012
Aerial America: On the Shores of the Great Lakes
Surrounded by four of America's Great Lakes, Michigan has more shoreline than any other state, and each of its shores has its own unique landscape, from forests to beaches to giant walls of sand.
—via High Five Threads
Posted by Tim Chilcote at 10:21 AM No comments:
Labels: Lakes and Rivers, Northern Michigan
Monday, April 16, 2012
Living in Detroit's Packard Plant [VIDEO]
A documentary film by Lost & Found.
Posted by Tim Chilcote at 9:30 PM No comments:
Ypsilanti Water Tower, circa 1900
Posted by Tim Chilcote at 2:48 PM 1 comment:
Sunday, April 15, 2012
Michigan Top 40 | 7 Extra Videos
Dale Earnhardt Jr. Jr., We Almost Lost Detroit
Dale Earnhardt Jr. Jr. - We Almost Lost Detroit from Dale Earnhardt Jr. Jr. on Vimeo.
Blog n' the D
Avoid the Noid
Dennis Coffey
Kid Rock, Born Free
Chet Lemon
Dale Earnhardt Jr. Jr. - We Almost Lost Detroit from Dale Earnhardt Jr. Jr. on Vimeo.
Blog n' the D
Avoid the Noid
Dennis Coffey
Kid Rock, Born Free
Chet Lemon
Posted by Tim Chilcote at 3:44 PM No comments:
Sunday, April 1, 2012
Michigan Top 40, Day 40 | Ernie Harwell's Farewell Address
Posted by Tim Chilcote at 8:05 AM No comments:
Labels: Michigan Top 40
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text:
Ghostwriting may be the oldest profession in the world, or at least one of the two oldest, which might explain the similarity of reactions they evoke. Jennie Erdal, who wrote Ghosting: A Double Life speaks of the time a professor from her university said she was "no better than a common whore".
Erdal's charming book — on ghosting for her employer, the flamboyant London publisher Naim Atallah (whom she calls 'Tiger') — caused a flutter when it appeared a decade ago. For ghostwriters, like spies, work in the shadows, and watch as other people take the credit for their work. Erdal's was a warm portrait of Atallah, who however, broke off all relations once the book appeared.
"The plumage is a wonder to behold," Erdal wrote of Tiger's exuberant attire, "a large sapphire in the lapel of a bold striped suit, a vivid silk tie so bright that it dazzles, and when he flaps his wings the lining of his jacket glints and glistens like a prism."
The judgement of critics: this lady can write. Yet why was she satisfied with ghosting for her boss — writing everything from his letters, poems, love notes to his wife, novels — when it seemed like a wilful limiting of her potential? For two decades, Erdal hid her light under a bushel, content that Atallah claim all the glory. At the launch of one of "his" books, someone asked Erdal if she had read it. She varied her answer from "yes, it's a classic", to "no, but I hope to," without ever sinking to "Read it? I wrote the bloody thing!"
"As a ghostwriter, you have to leave your ego at the door," said the Sydney journalist Michael Robotham (who wrote the autobiography of Spice Girl Geri Halliwell) whose first novel became a best-seller in 26 countries. "Ghostwriters tend not to make the best novelists," he said, "You are in a comfort zone as a ghostwriter. You earn very good money. And you don't have your name on the book. So if it fails, you don't fail publicly."
Sports stars, movie actors, politicians, businessmen, all use ghosts to write their stuff. There is a certain logic to this. The great inside forward or the method actor need not simultaneously be the literary giant of his generation too. After all, a Hillary Clinton is not expected to fix her own car or build her own house, so why should she be expected to write her own book? Turn to the professional, therefore. And that's what they do.
When President Kennedy's Profiles in Courage won the Pulitzer Prize, there were at least two candidates who emerged as the likely ghostwriters. Arthur Schlesinger Jr and Ted Sorensen, both advisors to the President and speech writers. Years later, Sorensen wrote in his autobiography that he "did the first draft of most chapters and helped choose the words of many of its sentences."
Many so-called prolific writers whose names appear in the record books for their phenomenal output used ghostwriters. Leslie Charteris was one. Many of the detective fiction writer Ellery Queen's books were written by others. Before the franchise (James Bond, Bertie Wooster) took over, there was the book-churning industry. This was acknowledged by Mildred Wirt Benson, creator of the Nancy Drew series. Benson wrote for the Stratemeyer Syndicate in New York under the pseudonym Carolyn Keene.
Her identity was kept secret until it was revealed in a court case in the 1980s. The books were translated into 17 languages and sold more than 30 million copies. However, when she wrote under her own name, the books didn't sell as well.
Next month, Andrew Crofts, one of the most successful writers of our generation, publishes his much-awaited Confessions of a Ghostwriter. A certain amount of de-masking is expected — "a bit of skirt-lifting, and more than a hint of saucy revelations," as The Guardian put it — although that would be going against the ghost's unwritten creed: Thou shalt not let down the 'author' whose name appears on the cover of the book. Crofts has written 80 books for various celebrities; these have sold over 10 million copies making him both rich and successful. His motto seems to be taken from something Harry S Truman said: "You can accomplish anything in life provided you don't mind who gets the credit."
Donald Bain, another veteran ghostwriter said he thought of writing as business, and had no ambition to be a Hemingway or a Grisham. Bain's favourite quote is from Charles Dickens — another writer who thought of novels not as high art, but as avenues for money-making. "When you have quite done counting the sovereigns received for Pickwick, I should be much obliged to you to send me up a few," Dickens wrote to a friend once. Bain has one way of getting his name into some of the books he writes — he dedicates them to himself.
One Nobel Prize winner ghosting for another might seem unreal, but when it is Gunter Grass (Literature, 1999) writing for Willy Brandt, the German Chancellor (Peace, 1971), then it becomes merely unusual. Grass's romance with politics saw him write for the leader of the Social Democrats. The Citizen and His Voice was published in 1974.
Credit was very much the topic of the day when the footballer David Beckham won an award for his autobiography My Side. Did the award belong to him or to Tom Watt who actually wrote the book?
Ghostwriting is big business. The vanity of the celebrity is the fuel that keeps the wheels turning and the hack living a life that is the envy of those whose writings appear under their own names. There is too the Association of Ghostwriters, a professional network to "help writers connect with clients and refine their craft."
Sportswriters are some of the finest ghostwriters in the world. A grunt by a sportsman to a banal question routinely appears in the media as a profundity from Socrates knocked into shape by Marquez. It is called "making the hero look (and sound) good."
Christy Walsh, who set up a syndicate to exploit the literary output of America's sporting heroes had a rule: "Don't insult the intelligence of the public by claiming these men write their own stuff."
Or that they always speak intelligently even. The ghost is the sieve through which the banal is converted overnight into the brilliant for popular consumption. Ghostwriting, you might say, is a public service.
The author is Editor, Wisden India Almanack


text:
3 Pro Kennex frames FS / FT
Up for sale......
Pro Kennex Black Ace 98 (315g Version)
Pro Kennex Q Tour
Pro Kennex Ki 5 PSE
All G5 but they measure under 4 1/2 !!
The BA has pallets and I have pallets and Butt caps to change to a G3
All 9 / 10 Condition.... Just some light scuffs to the bumpers not a mark on the paint.
All just strung with Weiscannon string...
£50 per frame inc shipping in the UK
£140 for all 3
May trade with PK Redondo Mid or BA Mid
Or maybe Head Prestige Mids
Or..... Any Mids ;-)
PSE Sold
QT and BA still available......
All sold
Thanks TW
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text:
Photo: Sanscurryhouse
Dosa, what can be said more about that being a common south indian breakfast which is thoroughly enjoyed right from infants to seniors. Dosa is a gluten free breakfast recipe in case you are allergic to wheat. Dosa can be compared to a pancake that's made more often with the combination of rice and white lentils. None can resist this dish with a spicy hot chutney, sambar or any other non vegetarian curry.
Yield: 4 servings
Community Recipe from
Recipe Time
Prep Time:
Cook Time:
- 3 cup(s) Idly rice
- 3/4 cup(s) White lentils(Urad dal)
- 1/2 cup(s) Rice Flakes/Beaten Rice/Poha(optional)
- 3/4 teaspoon(s) Fenugreek seeds(optional)
- 1 1/2 tablespoon(s) Salt
- Soak the idly rice in water for 5 to 6 hours or leave it overnight. Similarly soak the urad dal,poha and fenugreek seeds in water for few hours. Grind the rice separately and the urad dal, poha with fenugreek seeds separately to a thick consistency batter(pancake batter consistency) using a blender or grinder. Set it aside in a warm place because you got to get it fermented, the batter tends to raise from 1 inch to 2 inches depending upon the weather and the place where ever you reside. Add some salt and water to get the desired consistency.
- Now heat a skillet, grease it with some oil. Pour 1/4 cup of the batter on it spreading it evenly, pour some oil around the corner and flip the dosa. Dosa will turn little brown and crispy. This is just a plain dosa.
October 2011
This recipe is a personal recipe added by Sanscurryhouse and has not been tested or endorsed by MyRecipes.
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Dosa Recipe at a Glance
- COURSE: Breakfast/Brunch
- CONVENIENCE: Family
- CUISINE: Indian
- MAIN INGREDIENT: Rice/Grains
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text:
Osteoplasty material substantially devoid of antigenic proteins, wherein the material contains a natural bone structure in which non-denatured type I collagen is integrated, is prepared by selective extraction of bone tissue of human or animal origin. The selective extractant is an aqueous solution of 2-10 molar urea, and the extraction step is conducted at preferably 10°-30° C.
1. A method for producing an osteoplasty material, comprising
(a) providing a starting non-demineralized bone tissue of human or animal origin, containing antigenic, non-collagenous structural proteins and structural collagen,
(b) subjecting said bone tissue to at least one selective extraction of the antigenic proteins with an aqueous selective extraction agent containing urea at a sufficient concentration and a sufficient temperature so as to selectively decompose the antigenic non-collagenous protein structure without attacking type I collagen, and
(c) recovering an osteoplasty material for bone implants having the natural bone structure of the starting bone tissue and type I collagen integrated therein in non-denatured form.
2. The method of claim 1, wherein the urea is in the form of an aqueous solution at a concentration within the range of 2 to 10M.
3. The method of claim 2, wherein the selective extraction step is conducted at 10°-30° C.
4. The method of claim 2, wherein the concentration of the urea is 5-8 molar.
5. The method of claim 4, wherein the selective extraction step is conducted at 10°-30° C.
6. The method of claim 1, wherein said selective extraction is followed by a further selective extraction with an aqueous solution of urea containing mercaptoethanol in a concentration of 0.1 to 0.5 volume %.
7. The method of claim 1, wherein said selective extraction is preceded by extraction of soluble constituents into an ionic solvent.
8. The method of claim 1, wherein after completion of said selective extraction, at least one washing step which entrains denatured structural glycoproteins is performed.
9. The method of claim 1, wherein said washing step is carried out with distilled water at a temperature within the range of 30° C. to 60° C.
10. The method of claim 9, wherein the washing step is carried out at 45°-55° C.
11. The method of claim 1, wherein the selective extraction is conducted at 10°-30° C.
12. The method of claim 1, wherein, prior to said selective extraction, said starting non-demineralized bone tissue is subjected to a delipidation treatment.
13. The method of claim 12, wherein said selective extraction is followed by a further selective extraction with an aqueous solution of urea containing mercaptoethanol in a concentration of 0.1 to 0.5 volume %.
14. The method of claim 12, wherein said delipidation is carried out by contacting the starting non-demineralized bone tissue with a mixture of chloroform and methanol or a mixture of ethanol and dichloromethane in a proportion of approximately 10 liters to 1 kg of non-demineralized bone tissue.
15. The method of claim 14, wherein said selective extraction is followed by a further selective extraction with an aqueous solution of urea containing mercaptoethanol in a concentration of 0 1 to 0 5 volume %.
16. The method of claim 12, wherein said selective extraction is followed by a further selective extraction with an aqueous solution of urea containing mercaptoethanol in a concentration of 0.1 to 0. 5 volume %.
17. The method of claim 12, wherein said selective extraction is preceded by extraction of the soluble constituents into an ionic solvent.
18. An osteoplasty material obtained by a method in accordance with claim 1, wherein said osteoplasty material preserves the original and natural bone structure in which non-denatured type I collagen is integrated.
19. The osteoplasty material of claim 18, containing structural collagen in a proportion within the range of 20 to 40%.
20. The osteoplasty material of claim 19, wherein the structural collagen present is in a proportion within the range of 25-35%.
21. The osteoplasty material in accordance with claim 18, containing a proportion of lipids lower than 15%, a proportion of proteins within the range of 25 to 45%, a proportion of calcium of 10 to 30%, a proportion of phosphorus of 5 to 20%, and a water content lower than 10%, by dry analysis.
22. The osteoplasty material of claim 21, wherein the ratio calcium/phosphorus is from 1-2.2.
23. The osteoplasty material of claim 18, wherein said osteoplasty material is formed into parallelepipedal blocks, pyramidal frustums, lamellae, centro-medullary end-caps, disks or powder optionally amalgamated by means of a binder of biological origin or of synthetic origin.
24. A method for producing an osteoplasty material, comprising
(a) providing a starting non-demineralized bone tissue of human or animal origin containing antigenic, non-collagenous structural proteins and structural collagen,
(b) delipidating the non-demineralized bone tissue of (a) to remove free lipids therefrom,
(c) subjecting said bone tissue to at least one selective extraction of the antigenic proteins with an aqueous selective extraction agent containing urea at a sufficient concentration and a sufficient temperature to selectively decompose the antigenic non-collagenous protein structure without attacking type I collagen,
(d) recovering an osteoplasty material for bone implants having the natural bone structure of the starting bone tissue and type I collagen integrated therein in non-denatured form, and
(e) optionally washing and rinsing the osteoplasty material of (d).
This application is a continuation, of application Ser. No. 07/858,985, filed as PCT/FR90/00842, Nov. 22, 1990, published as WO91/07194, May 30, 1991, now abandoned.
The present invention relates to material intended for osteoplasty as well as to a method of manufacture for obtaining said material from bone tissue of human or animal origin. The essential object of the invention is to provide surgeons with bone substitute material which is biocompatible, non-antigenic, osteocompatible, osteointegrable, etc.
This invention is intended to produce grafts or transplants which can be recut to the shape of the bone defect, thus enabling surgeons to employ a graft of this type as an alternative either to an autograft which accordingly makes it possible to dispense with the second operating site or to a homograft on account of the drawbacks and dangers involved.
This material is advantageously improved with respect to those of the prior art by virtue of its method of manufacture which is particularly well suited to the formation of a bone graft in reparative, traumatological, orthopedic, maxillofacial or mandibular surgery as well as in dental or veterinary surgery and, in a general sense, whenever a bone site calls for the use of a graft.
The use of replacement or substitute bone tissue is not a new technique. The first scientific publications date back to the vicinity of 1800 and have greatly increased in number since that time. They relate to homografts and xenografts containing relative proportions of minerals and proteins which may vary according to the methods adopted. A parallel development which has taken place subsequently to the initial use of these bone substitutes of human and animal origin has consisted in the use of grafts of a mineral nature such as corals, hydroxyapatites, ceramics or of synthetic nature such as biodegradable polymer materials.
At the present time, research efforts undertaken in this field are being directed to the use of materials which are closer to bones both in structure and in composition, and specifically to human bone, in order to facilitate integration of the bone graft. This involves recognition by the body of the new structure and colonization in accordance with the so-called "creeping substitution" mechanism.
Bone is a living tissue which undergoes a never-ending process of reorganization involving simultaneous destruction and reconstruction of bone material. In the normal process, but also when foreign material is implanted, the osteoclasts resorb the old tissue, thus leaving a gap in which the osteoblasts generate the new tissue. A balance is always maintained between the quantities of resorbed bone and the quantities of newly formed bone. It appears that this phenomenon is likely to take place with greater ease as the implanted structure bears a closer resemblance to that of normal bone.
Thus it is now preferred to prepare bone substitution materials from natural bone tissues which are preferably of animal origin for ethical and practical reasons.
Generally speaking, it is known that partial demineralization facilitates integration of a bone graft. This is accordingly followed by different complementary steps which are intended either to deproteinize the bone completely or to act on the nature of the proteins which then remain linked within the bone matrix or else to increase this proportion of proteins.
In the prior art, there may be cited in particular U.S. Pat. No. 4,394,370 which proposes to fuse into a spongy mass by means of a glutaraldehyde binder which has a cross-linking effect, a mixture consisting of powdered demineralized bone of human origin and of reconstituted collagen powder.
U.S. Pat. No. 4,743,259 combines demineralization by hydrochloric acid with enrichment with proteins carried out on a first fraction of demineralized bone by means of proteins extracted from a second fraction by guanidine.
Moreover, French patent Applications No. 2,582,517 and No. 2,582,518 propose to treat fragments of bones taken from animals, more especially from cattle, by partial demineralization and tanning by means of glutaraldehyde. The bone elements to be implanted by the surgeon are cut to the appropriate shape from an ox bone which has previously been subjected to a treatment comprising a delipidation or degreasing step with an organic solvent such as ethanol, a demineralization step by means of a calcium extraction agent such as hydrochloric acid, and a step which involves tanning with glutaraldehyde, as well as various washing operations.
It is apparent from the specifications of the patents cited in the foregoing that the above-mentioned tanning process has a beneficial effect on the properties of treated bone insofar as it facilitates cross-linking of the macromolecular chains. However, it has now been found that, on the contrary and in contrast to the suggestions made in the prior art, the treatment with glutaraldehyde does not result in any appreciable reduction of the immunogenic properties and, in addition, reinhabitation of the implanted bone is not promoted as should preferably be the case in order to ensure integration of the bone graft. Furthermore, chemical compounds such as glutaraldehyde have the disadvantage of being biologically toxic.
When the present invention was conceived, a condition observed at the outset was that, in order to achieve good integration of the bone graft, it is essential to maintain the collagen in the bone material while keeping it in the specific form which it has in natural bone (mainly in the form of type I collagen) and at the same time maintaining the microscopic appearance of the bone, as well as to preserve the spatial bone structure which is intended to support a subsequent colonization of cells. It has also been observed that the treatments of the prior art have substantially the same effect on the collagen of the bone as on the other proteins which they are intended to remove or to denature in order to eliminate their antigenicity.
The invention is therefore directed to a method of treatment of bone tissue of human or animal origin which results in bone substitute material characterized by the preservation of the original bone structure, which integrates non-denatured type I collagen but which is freed from the antigenic proteins. The method results in the surprising discovery that it is possible to carry out on natural bone tissues a step of selective extraction of the antigenic proteins while preserving the structural collagen.
In more specific terms, the method in accordance with the invention essentially involves at least one step of selective extraction and/or denaturation of the non-collagenous structural proteins, this step being carried out by means of a selective extraction agent having a base of urea. Within the field of the present invention, urea is advantageously employed in the form of an aqueous solution at a concentration which is usually within the range of 2 to 10M and preferably 5 to 8M. The temperature is ordinary temperature or may generally have a value within the range of 15° to 30° C.
The analytical follow-up of the method in accordance with the invention involving utilization of urea or of a similar extraction agent shows that the reactions thus produced tend to break the macromolecular chains of the undesirable proteins which remain in the structure of the original bone after carrying out conventional delipidation operations whereas the structural collagen is practically not attacked. The material obtained is distinguished not only by its properties relating to applicability but also by its characteristics of composition and structure from all materials known up to the present time for the same application, in particular those which involved reincorporation of skin collagen in a demineralized bone skeleton or those directed to restructuration of the collagen since this appears to lead to a system of crystallization which is different from natural crystallization.
In a preferred mode of execution of the invention, the method does not include preliminary operations of partial demineralization of the delipidated bone. However, the known techniques of demineralization may also be used at this stage.
After the essential extraction step in accordance with the invention, the method advantageously includes a subsequent washing step which is conventional per se and serves to remove the proteins from the bone material during treatment, selectively with respect to the collagen having a non-denatured structure. In the practical application of the method in accordance with the invention, this washing step is preferably carried out at a temperature within the range of 30° C. to 60° C. and preferably of the order of 45° C. to 55° C. An advantageous compromise is thus achieved between the desirable removal of proteins and preservation of the collagen in its untanned form, which has a beneficial effect on the final properties of the material to be implanted in bone surgery.
In accordance with secondary features of the invention, the method may involve a repetition of the essential step of selecetive extraction by urea, advantageously combined with another agent which is capable of breaking the disulfide bridges such as mercaptoethanol, this step being followed each time by a suitable washing step.
Moreover, the method as a whole may also include a number of different steps which are conventional per se and especially a step of extraction by an ionic solvent consisting in particular of an aqueous solution of a salt such as sodium chloride.
It will be noted that, in the practical application of the method according to the invention, the extraction agents employed can be readily selected from compounds which do not have any toxic effect on the human body, which is not the case, for example, with glutaraldehyde employed in the prior art.
In its preferred embodiments, the method in accordance with the invention results in bone material in which the usual analytical techniques make it possible to detect the presence of structural collagen in a proportion which is advantageously within the range of 20 to 40% and preferably of the order of 25 to 35%.
It is therefore clear that, on completion of the treatment, the material obtained does not contain all the original collagen which is known to represent approximately 90% of the organic material of the degreased dry bone, approximately 95% of this proportion being made up of type I collagen, characterized by a molecule of tropocollagen formed by three polypeptide chains arranged in a helix, comprising two type I alpha-1 chains and one type I alpha-2 chain, and approximately 5% of type III collagen, which comprises three identical alpha-1 chains. Nevertheless, only the collagen which is readily extractable at the same time as other proteins is removed during conventional operations consisting of preliminary delipidation and demineralization if necessary, whereas the greater part of the structural collagen remains unattacked when the other proteins which had not previously been removed are denatured by urea, these products being essentially constituted by proteoglycans or antigenic glycoproteins.
However, the properties of the material obtained by the method in accordance with the invention, especially its capacity for osteointegration but also its mechanical properties and its formability appear to be precisely related to the presence of the original collagen which is integrated in the microporous structure and mainly consists of type I collagen. It is also worthy of note that the invention usually leads to relative enrichment of the collagen in type I collagen up to a proportion for example of 97% of type I collagen and 3% of type III collagen.
This result is observed in the material obtained in accordance with the invention by means of known techniques of characterization of types of collagen which consist for example either in observing the collagen by immunofluorescence after having caused it to react with anti-collagen (type I) antibodies or in subjecting it to the action of cyanogen bromide in order to obtain a mixture of characterizable peptides which are separated as a function of their molecular weights and analyzed by electrophoresis.
In the majority of instances, the material in accordance with the invention and obtained in accordance with the method in which recourse is had to preliminary partial demineralization has a composition within the ranges indicated hereunder (in % by weight):
______________________________________Water 2-10 or less than 10Lipids 1-15 or <15Ash 40-65Calcium 10-25Phosphorus 5-20Ca/P 1-2.2Proteins 30-45Collagen 20-40______________________________________
In the preferred case in which the method does not involve preliminary partial demineralization, the material advantageously has a composition within the ranges indicated hereunder:
______________________________________Water <10Lipids <2, namely 0, 1-2Minerals 50-70Calcium 20-30Phosphorus 10-17Ca/P 1.6-2.2Proteins 25-35Collagen 20-30______________________________________
The invention will now be described in greater detail within the scope of particular examples of application of the method and of clinical uses of the material, these examples being given without any limitation being implied.
Preparation of the material in the form of blocks.
The starting material consists of blocks of bone cut-out beforehand from epiphyses or diaphyses of ox bones freshly obtained from the slaughterhouse. Depending on the intended use, preference may be given to spongy bone (epiphysis) or to cortical bone (diaphysis). In the case under consideration, in which good compressive strength is desired, it is preferable to carry out transverse cuts of epiphyses at right angles to the trabecular framework.
These blocks are first treated in accordance with a conventional step of delipidation of the bone tissue with a mixture of chloroform and methanol or of ethanol and dichloromethane, the volume of delipidating mixture being approximately 10 volumes for 1 part of initial fresh bone (10 l/kg). This step permits extraction of free lipids, fatty acids, lipoproteins, associated with the bone stroma. In the example under consideration, this step is carried out as follows: 400 g of blocks of bone are treated with a mixture of 4 l of chloroform and methanol (2/3-1/3) at a temperature of 4° C. over a period of 24 hours with agitation.
Throughout the remainder of the operations and unless otherwise stated, this proportion of 10 volumes for one part of initial bone will be maintained.
In an example Ia (but not in an example Ib), the blocks are then subjected to a demineralization step performed by contacting them with 0.6M hydrochloric acid at 4° C. over a period of 6 hours. This step is conventional and the operating conditions can be varied in accordance with the description given for example in French Patent No. 2,582,517, by employing a hydrochloric acid solution having a molar concentration within the range of 0.1M to 1M, or another mineral or carboxylic acid and/or an organic agent which is capable of complexing the calcium of bone such as ethylenediaminetetraacetic acid.
By way of alternative, it is also possible to increase the time of contact with HCl, for example to thirty-six hours. Depending on the treatment time, the material obtained will have a greater or lesser degree of hardness adapted to requirements for future use.
During this demineralization step, the ions of hydroxyapatite which forms part of the bone collagen stroma are therefore removed in part, thus making this stroma more accessible for subsequent extractions.
The following step consists of an extraction by contacting with an aqueous solution of sodium chloride: the blocks are treated with 4 l of a 1M sodium chloride solution at a temperature of 4° C., with agitation, over a period of thirty-six hours.
This extraction makes it possible to remove the most soluble or freshly synthesized macromolecular components from the bone material. In the extract are found lipids which had remained after the previous treatments, proteoglycans and collagens. This step makes it possible to avoid denaturation of the collagen stroma while partially extracting a few components before attacking the more resistant matrix components in the following extraction steps.
In Example Ia as in Example Ib, the extraction operation just mentioned immediately precedes the essential step of the invention, in which the bone blocks are put in contact with 4 l of 8M urea at room temperature (20° C.) over a period of six hours.
This step permits extraction of molecules such as proteoglycans and glycoproteins including the structural glycoproteins which are molecules having the highest antigenicity in bone, but without causing excessive denaturation of the conjunctive collagen stroma.
This extraction is completed by a fresh extraction having a similar purpose and carried out by means of a 0.2% solution of mercaptoethanol in 8M urea at room temperature over a period of twenty-four hours.
When both of these two selective extraction steps have been completed, it is found that the non-collagenous glycoprotein elements have been extracted or at least denatured in an effective manner, thus preventing rejection of the material to be grafted as a result of the natural antigenicity of its glycoproteins which are present in the macromolecular composition of the bone tissue stroma.
The different solvents and reagents employed during the preceding operations are then removed by washing with 4 l of distilled water at 55° C. over a period of twenty-four hours.
There then follows a treatment with a 0.4M phosphate buffer solution (pH =7.4) which is carried out with agitation over a period of forty-eight hours at 35° C. This operation is followed by rinsing with 2 l of ethanol at room temperature over a period of twenty-four hours.
Vigorous washing with pure water serves to remove or rather to continue the extraction of lipids, proteoglycans, collagens and glycoproteins. The treatment temperature employed makes it possible to inhibit the enzymatic activities which are present in the tissues, namely those derived from endogenous proteases or exogenous proteases of bacterial origin, for example, as well as other lytic enzymes.
As far as extraction with the phosphate buffer solution is concerned, this operation continues removal of the matrix and/or lipid components which may still be attached to the bone stroma. The extraction process also makes it possible to restore the equilibrium of the bone material in regard to the salts which are present.
Finally, washing in an alcohol bath permits final and complete extraction of the compounds which are still weakly associated with the collagen stroma, in particular residual lipids, but primarily facilitates the subsequent isolation operation.
In fact, the bone fragments treated in accordance with the invention with a view to obtaining osteoplasty material are finally drip-dried, rinsed with ethyl alcohol and dried in a ventilated oven. They can also be frozen and/or lyophylized in order to be stored in readiness for use. Individual parts can readily be formed so as to obtain the shapes which are suitable for use. Thus the material can be provided in the form of parallelepipedal blocks having different dimensions, pyramidal frustums, lamellae, centro-medullary end-caps, disks, and so on. The final forms are then packaged and sterilized by ionizing radiation.
Analytical Study.
The material finally obtained was subjected to microscopic, biochemical and chemical examinations.
a) Examination in optical microscopy, optical and polarized light. This examination shows that the structure of the bone tissue is preserved. It is seen especially that the characteristic appearance of the trabecular framework of the spongy tissue again has its characteristic appearance. It is established in particular that the collagen is present in its original arrangement, thus making a very marked difference between the material in accordance with the invention and any products of the prior art which might result from an addition of exogenous collagen on any support.
b) Examination in fluorescence microscopy. This examination permits characterization of the specific lamellar structure which is very close to that of natural bone. Characterization of the type I collagen was achieved by making use of specific type-1 anti-collagen antibodies.
c) In biochemistry, typing with cyanogen bromide confirms that the collagen is in fact type I collagen. It is found that alpha-1 CB7 and alpha-1 CB8 peptides are present. The presence of alpha-1 CB6 peptides confirms the cross-linkage of the chains and therefore the partial preservation of the spatial structure. The presence of alpha CB3 is also noted.
These results, compared with the reference substances, reveal the presence of a characterized type I collagen.
d) In chemistry, a mean value of the analyses performed on four batches resulting from the application of the method in accordance with Example I gives the following results expressed as a percentage by weight with respect to the total weight of dry materials:
Example Ia:
______________________________________Quantity determination Mean value % Extreme values______________________________________Loss on drying 6.8 6.3-7.3Lipids 10.8 7.4-14.0Ash 48.4 44.6-53Calcium 16.8 15.5-18.0Phosphorus 11.5 8.8-13.4Ca/P 1.49 1.22-1.86Proteins 36.8 35.4-38.5Collagen 30.2 29.5-30.7______________________________________
Example Ib (analyses of six batches):
______________________________________Quantity determination Mean value % Extreme values______________________________________Water 8.9 7.3-9.7Lipids <0.3 <0.3Ash 61.7 60-65Calcium 22.64 21.5-25.3Phosphorus 11.5 10.3-12.4Ca/P 1.97 1.7-2.22Proteins 29.6 28-31Collagen 27.3 25.6-29.3______________________________________
The mean apparent density of the product varies between 0.32 and 0.57 g/cm3 depending on the samples, about a mean value of 0.39 g/cm3.
preparation of material in powdered form.
Fragments taken from ox bones (without any need for concern as to the orientation of cutting planes) are treated as described in Example I. They are then reduced to powder which can be used directly as it stands.
Preparation of molded material.
By way of alternative, powders having different particle sizes are employed at the outset to mold parts to the desired shapes by means of a binder which can advantageously be of biological origin but may also be a biodegradable synthetic polymer according to its intended use.
In the particular case of the present example, material having the function of a binder and formed so as to permit revascularisation (such as a bioresorbable polymer of the polylactic resin group) was employed in a proportion of 1 to 10 parts to 1 part of bone powder. It would also be possible to employ fibrin in a proportion of 1 or 2 parts to 100 parts of bone. The particle size of the powders varies from 1000 to 250 μ.
The final formed parts are then sterilized by irradiation and sealed in a sterile package.
Variants of the method.
Ox bones are treated as in Example I except for the fact that final washing with alcohol is preceded (before or after washing with distilled water) by a further step of delipidation by a mixture of chloroform and methanol or a mixture of ethanol and dichloromethane.
This step permits final and complete delipidation of the conjunctive bone stroma and therefore permits removal of the lipidic substances, fatty acids or lipoproteins which still remain attached to the bone stroma. By carrying out this extreme delipidation, it is thus possible for example to obtain under better conditions a bone powder in accordance with Example III having a composition of residual lipids which is advantageously reduced to a proportion of less than 5%.
Similarly, it may be advisable to add two additional delipidation steps, thus making it possible to obtain a product containing a wholly negligible proportion of residual lipids, namely of the order of 1% or less than 1%.
As can readily be understood, the relative percentages of the other constituents are modified under these conditions.
Changes have also been made in the conditions of the different treatment steps, especially in concentrations, contacting times and temperatures, by applying them to blocks in which the three dimensions varied between 8 and 30 centimeters. The limits of the conditions adopted were as follows:
Suppression of the step involving extraction by an ionic solvent, which in other cases is performed by means of a 0.5 to 2 M solution of NaCl at a temperature of 2° to 5° C. over a period of twelve to thirty-six hours.
Aqueous solution of urea having a concentration within the range of 5 to 10M.
Aqueous solution of mercaptoethanol in urea containing 0.1 to 0.5 volume % of mercaptoethanol.
Time of selective extraction by this solution, within the range of twelve to thirty-six hours at room temperature.
Satisfactory materials for osteoplasty have thus been obtained, the results of analysis of these materials being within the following ranges (% by weight):
______________________________________Ash 40 to 70, especially 60 to 65%Lipids 0.5 to 2%Loss on drying 7 to 10%Proteins (Kjeldahl) 25 to 45%Calcium 10 to 30% (10 to 20 or 20 to 30)Phosphorus 10 to 17%Ratio Ca/P H 1 to 2.2 (1 to 1.3 or 1.6 to 2.2)Collagen 33 to 38%______________________________________ (dosage of collagen according to hydroxyproline)
The same results are obtained in the variants of the invention involving the use of a powder as is described in Example III.
Clinical observation on a one-year-old castrated male cat.
This animal had been the victim of an accident (traumatic shock caused by an automobile) which resulted in a comminuted fracture of the right thigh bone at the level of the proximal metaphyseal and trochanteric region. By making use of the osteoplasty material in accordance with the invention, the cat was operated-on eight days after the traumatism by means of the following technique: conventional approach of seat of fracture, insertion of a block prepared in accordance with Example I in the reconstituted trochanteric mass and synthesis by reconstruction of the femoral diaphysis by means of the Perot small-size external fastener (threaded transfixing pins 2 mm in diameter).
The animal was restored to a completely normal walking, running and jumping function. Radiographs taken at intervals of sixty and ninety days showed satisfactory bone reconstruction and incipient union of the graft. This made it possible to avoid the complications of a fracture which could have led to amputation of the limb in the event of non-consolidation.
German sheepdog.
This animal had been the victim of a road accident which resulted in a comminuted diaphyseal fracture with splinter. Operation of the dog was carried out rapidly and was followed by placement of a heterologous graft prepared from a block of ox bone treated as in Example I. The graft was sculptured in the block so as to obtain a tongue-and-groove assembly at the level of the femoral diaphyseal ends to be joined. Solidification of the osteosynthesis assembly was achieved by apposition of a Perot straight plate and screwing on the femoral diaphysis with a 3.5 mm diameter screw.
The animal recovered its support after only a few days. Radiographic tests carried out at intervals of thirty and sixty days showed stability of the assembly and incipient union of the graft.
Use of the material in accordance with the invention in powdered form for apical resection on a patient's upper left lateral incisor.
The operation was performed in accordance with a conventional technique, namely semilunar incision with exeresis of the cyst and sterilization of the site with a C02 laser. Placement of the material according to the invention and in powdered form as obtained in accordance with Example III was carried out by mixing it with sterile physiological serum and by compressing it within the sanguinolent osseous geode. The gingival flap was then replaced and sutured and a test radiograph was taken.
It was noted after a period of eight days that excellent cicatrization had begun. After one week, the quality of the radiographic image was much better than those obtained with the other filling materials employed in standard practice. Thus the radioopacity of the material in accordance with the invention is very close to that of human alveolar bone.
At intervals of two weeks and one month, the radiographs confirmed these results. Cicatrization was perfect and no rejection phenomenon had appeared.
From the evidence shown by the radiographic appearance, it may be asserted that "integration" of the powder takes place. In the experience of the practitioner who performed this operation, this is wholly exceptional in comparison with the results observed in the case of the other known filling products which are commercially available.
Use of the material in accordance with the invention for restoring two periodontal pockets to a sound condition in a 50-year-old patient.
The operation consisted first in reclining a flap which extended from the upper left central incisor to the second upper left molar, then in sterilizing the bone and root portions of the pockets by deep scaling, curetting and surfacing of roots.
The granulation tissue at the gingival level on the flap and within the pockets was volatilized by means of a CO2 laser, whereupon the periosteum and the pockets were rinsed with physiological serum.
Two blocks prepared in accordance with Example I were employed. These sterile blocks were cut to the required dimensions under strictly sterile conditions. The two blocks were forcibly fitted in position so as to establish an intimate contact and serve as retention means. On completion of this operation, the flap was then replaced and sutured.
Eight days after removal of the surgical bandage, when the stitches had been removed and the operation site had been cleaned, it was observed that certain stitches (two) had failed and that the two blocks were not perfectly covered since they were still slightly visible. However, the cicatrization state was satisfactory and, surprisingly, a neo-gum of the kind which normally develops at the level of the periosteum when this latter has been bared was found to be developing above the blocks. This may accordingly be considered to constitute "recognition" of the material in accordance with the invention by the neogum. This result is confirmed by the radiographic test.
After a period of two weeks, the two blocks of the material in accordance with the invention were entirely covered by the transfer flap and by the neogum at the level of the uncovered zones.
This confirms that, by virtue of its "neutrality" or its structure which is close to that of human alveolar bone, the material in accordance with the invention integrates perfectly and is covered by a neogum as is the case with the periosteum.
The final radiograph taken at the end of one month confirms that the two blocks had perfectly integrated in their site. No rejection phenomenon was observed. Furthermore, the teeth were no longer liable to move and the gingival appearance was restored to normal, which is exceptional in view of the problems arising from postoperative sutures.
Patent Citations
Non-Patent Citations
Referenced by
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DMV to Internet-less New Yorkers: Get in Line
By Jared Chausow
By Katie Toth
By Elizabeth Flock
City Hid Facts From Feds About Rikers
By Albert Samaha
Flood Wall Street Gets Pepper Sprayed and Arrested
By Anna Merlan
By Jon Campbell
Report Sheds Light on Anti-Muslim Bias
By Jon Campbell
Rikers Island Lawsuits Over Diabetic Care
By Albert Samaha
Operating under the guidelines of the Handschuh agreement, a memorandum of understanding limiting political surveillance, the New York City police have also developed intelligence on potentially violent protesters. Meanwhile, they're taking care to avoid doing anything that might be construed as interfering with the right to free speech for those with no history of lawbreaking. "That is the tightrope we walk, as we should," Timoney says.
It was Timoney who during the 1992 Democratic National Convention in New York selected Michael Julian to head the initiative to allow for peaceful protest while preserving order in the city and the rights of the conventioneers. "Mike is the guy we know who cares the most about these rights," he says.
Julian"a new-age wheel" in police parlancehas since gone on to the executive suite of Madison Square Garden. While he is reluctant to talk now, back then he said, "We have to give these people the place to protest, but we don't have to give them the right to interfere with others, do we?" So he erected "pens" that gave protesters a view of the entrance to the convention but kept them far enough away to allow delegates free entrance and egress.
Much the same strategy will be in effect outside the Waldorf. The major difference from the point of view of the intelligence and security services is the presence of as many as 70 international leaders.
"Basically, Secret Service will provide 24-7 protection for each head of state and their accompanying spouse," says Steve Carey, special agent in charge for this region. In addition to the plainclothes members, officers from the heavy-weapons-trained uniformed Secret Service division will also be on hand. Carey's colleague Patricia Kelly, of the State Department Diplomatic Security Service, provides similar security for ministers and other foreign dignitaries. She points out that no matter how good a job the federal agents do, the bulk of the responsibility will fall on Ray Kelly's NYPD.
"Our concern is very high," she says, "but we have a very strong team and the New York City Police are exceptional at what they do."
Now the world will see whether they can walk that line between protection and repression, whether they can hold back anarchists who have prevailed elsewhere, and whether Ray Kelly is prepared enough to keep order in New York without getting his own forces spanked.
Related story:
"A Field Guide to Anti-WEF Protest in New York City" by Ariston-Lizabeth Anderson
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Las Vegas, Nevada
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This was the best Christmas present ever! Wonderful pilot, great tour and absolutely breath taking views. I highly recommend this tour to everyone!
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HNHSoftTwitter Statistics
@HNHSoft - Tracking since March 29, 2010
Turn your mobile phone or PDA into a talking language tutor with HNHSoft applications. Supports iPhone, iPod, BlackBerry, Window Mobile, Palm, and Java phones.
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text:
Computer-Assisted Counseling in Helping African American Smokers Stop Smoking
Basic Trial Information
|Protocol IDs
|No phase specified
|Behavioral study, Prevention
|21 to 65
|NCI, Other
Trial Description
RATIONALE: Stop-smoking plans using a nicotine patch, in-person counseling, and computer-assisted counseling may help people stop smoking.
PURPOSE: This randomized clinical trial is studying how well computer-assisted counseling helps African American smokers stop smoking.
Further Study Information
- Develop and evaluate the efficacy of an interactive, culturally sensitive, individualized, palmtop computer-delivered smoking cessation intervention for African American smokers.
- Examine how hypothesized treatment mechanisms mediate the effects of computer-delivered treatment on abstinence.
OUTLINE: This is a randomized study. A subset of 20 participants are assigned to arm II for pilot testing. All other participants are randomized to 1 of 2 intervention arms.
- Arm I (standard care [SC]): Participants receive nicotine patch therapy on days -5 to 31. Participants also receive a Pathways to Freedom self-help guide and undergo 5 in-person counseling sessions based on the Treating Tobacco Use and Dependence Clinical Practice Guideline. The counseling sessions occur at 12 and 5 days prior to the quit smoking date and at 3, 10, and 31 days after the quit smoking date.
- Arm II (computer-delivered treatment [CDT]): Participants receive the same intervention as in arm I. Participants also undergo CDT for 6 weeks comprising 5 modules (quitting strategies; motivation and support; general smoking information; calendars and fun stuff; and daily tips) beginning 12 days prior to the quit smoking date and continuing for 31 days after the quit smoking date.
All participants complete questionnaires at baseline, during the counseling sessions, and then at approximately 6 months after the quit smoking date.
After completion of study intervention, participants are followed at approximately 6 months.
PROJECTED ACCRUAL: A total of 500 participants will be accrued for this study.
Eligibility Criteria
Inclusion Criteria:
1. African American
2. Age 21 to 65 years
3. Current Smoker (history of at least 5 cigarettes/day for the last year)
4. Motivated to quit within the next 14 days
5. Participants must provide a viable home address and functioning home telephone number
6. Can speak, read, write in English at a sixth-grade literacy level
7. Provide viable collateral contact information
8. Register "8" or more on a carbon monoxide breath test
Exclusion Criteria:
1. Contraindication for nicotine patch use
2. Active substance dependence (exclusive of nicotine dependence)
3. Regular use of tobacco products other than cigarettes (cigars, pipes, smokeless)
4. Use of bupropion or nicotine products other than nicotine patches supplied by the study
5. Pregnancy or lactation
6. Any active illness that precludes full participation in the study protocol
7. Another household member enrolled in the study
Trial Contact Information
Trial Lead Organizations/Sponsors
M. D. Anderson Cancer Center at University of Texas
- National Cancer Institute
Link to the current ClinicalTrials.gov record.
NLM Identifier NCT00310141
ClinicalTrials.gov processed this data on February 27, 2015
Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.


text:
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extreme magic sing karaoke song torrent search results. 12 downloads match the criteria.
extreme magic sing karaoke song torrent search results. 12 downloads match the criteria.
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I recently upgraded from Daz 4 to 4.5. I re-installed almost everything except the body and head morphs I bought a year or so ago. Now I can't find them in my downloads area, or on my hard drive anywhere. Any help would be most appreciated.
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Estimated ArrivalArrives by 12/23
- Jun 08 - Jun 11
- Returns:
- Returns accepted within 14 days of delivery.
The Moroccan-inspired embroidered motif on the front of this pillow injects a taste of Tangier into your home. An insert of feather-and-down ensures your pillow stays plump. Solid back. Made in India.


text:
Gold Nanomedicine Clinical Trial Delivers Promising Results
delighted with the successful phase 1 clinical trial of a unique nanomedicine
that uses nanoparticles of gold as the core of a delivery system for tumour
targeted drug delivery. The research, published in the current edition of
Clinical Cancer Research, was carried out by US-based life sciences company
CytImmune Sciences Inc.
CytImmune's technology is at the forefront of a raft of gold-based
innovations as described earlier this year by the WGC in a paper entitled
'Gold for Good: Gold and nanotechnology in the age of innovation'. The report
demonstrates how gold nanoparticles exhibit a variety of unique properties
which are showing great potential in a range of fields.
long history in the biomedical field, being the material of choice in many
diagnostic platforms and a key constituent for rheumatoid arthritis
treatment. The dawn of the 'nano-age' has further broadened the potential of
gold in biomedical applications and it is exciting to see the outcome of this
clinical trial which suggests that gold can act as an effective and safe drug
delivery system."
In medicine, gold nanoparticles can serve as a simple, elegant platform
upon which potent therapies may be bound. In this clinical trial the
nanoparticles, which were coated with both an immune-avoiding molecule and a
potent anti-cancer agent, were shown to be very well tolerated and to target
solid tumours. There is hope that such targeting technology will be effective
against a range of cancers, including lung, pancreatic, breast and ovarian
clinical study potentially marks the beginning of a new strategy in cancer
treatment where gold nanoparticle-based cancer therapeutics are used first,
before surgery, to reduce tumour burden. Reducing tumour size may require
less sophisticated surgeries to remove any residual tumour, leading to
shorter hospital stays and to improved patient outcomes. Phase 2 clinical
studies will prove the value of this novel drug delivery platform."
Dr Holliday continued: "By continuously reviewing and monitoring the
global research landscape in gold science and technology, we are able to
identify and, where appropriate, help accelerate the time to market key, new
technologies that have social, environmental or medical benefits."
e_of_innovation.pdf (Gold for Good white paper)
(Due to the length of this URL, it may be necessary to copy and paste
this hyperlink into your Internet browser's URL address field. Remove the
space if one exists.)
http://www.cytimmune.com/ (CytImmune website)
http://clincancerres.aacrjournals.org/content/16/24/6139.abstract (Link
to paper abstract)
Note to editors: World Gold Council The World Gold Council (WGC) is the market development organisation for the gold industry. Working within the investment, jewellery and technology sectors, as well as engaging in government affairs, its purpose is to provide industry leadership, whilst stimulating and sustaining demand for gold. The WGC researches and gives insight on the international gold markets, helping people to better understand the wealth preservation qualities of gold and its role in meeting the social and environmental needs of society. Based in the UK, with operations in India, the Far East, the Middle East, Europe and the USA, the WGC is an association whose members include the world's leading gold mining companies. For further information visit http://www.gold.org.
SOURCE The World Gold Council


text:
The BSF has handed over two Pakistani nationals who had inadvertently crossed into Indian territory to the Pakistani authorities, an official said on Saturday.
Mushtaq and Shahid, were nabbed by the Border Security Force (BSF) troopers in the Abohar and Ferozepur areas along the India-Pakistan border in Punjab Friday. "During questioning, both these Pakistani nationals were found to have crossed the border inadvertently. Nothing objectionable was recovered from their possession," the BSF Punjab Frontier spokesman said.
The BSF contacted their Pakistan counterparts - Pakistan Rangers - and handed over the men to them.


text:
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Boat Description
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