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In case number 14-571 , the U.S. Supreme Court is considering the case of Michigan residents April DeBoer and Jayne Rowse. Arguments are scheduled for April 28th, and a decision is expected by late June.
The briefs submitted to the Supreme Court highlight two issues:
1. Does the Fourteenth Amendment require [...]
Entries Categorized as 'Families/Children'
The evolving future of marriage
April 19, 2015
In case number 14-571 , the U.S. Supreme Court is considering the case of Michigan residents April DeBoer and Jayne Rowse. Arguments are scheduled for April 28th, and a decision is expected by late June.
From courtroom to the capitol: Fathers rights in custody cases
April 16, 2015
The Wall Street Journal covers the push for legislation in about 20 states to give fathers more child custody rights in divorce cases.
when No is better than Yes
March 1, 2015
On Being offers 5 different ways to say "No."
On saying No gracefully, Courtney E. Martin writes (excerpt):
1. No, for now.
2. No, but here are some awesome resources.
3. No, but have you tried our mutual friend?
4. No, I can't do that, but I can do this.
5. Let me think about it.
Get rich quick: scouting for amazing friends
January 4, 2015
On Being reminds us "why it's such an outrageous blessing to have the opportunity to choose our friends."
Courtney E. Martin writes (excerpt):
So now that the family circus is over for another season and you're turning your attention to the beginning of a new year, consider this for a resolution: become a fierce talent scout of [...]
You can do it too: ordinary people acting heroic
December 18, 2014
CNN entices us with the title: "5 ways to be extraordinary." In discussing five extraordinary people, Brandon Griggs lists these categories:
1. Show courage in a crisis
2. Exhibit grace under pressure
3. Meet evil head on
4. Miracles are within your grasp
5. Share credit for your success
In the darkest moments of our lives: Col. Jessep's "You want answers?"
December 6, 2014
On Being highlighted one of my favorite quotes in a post about The Questions We Ask Ourselves.
The words of Rainer Maria Rilke offer a bit of light in moments of blinding darkness:
"Be patient toward all that is unresolved in your heart… Try to love the questions themselves… Do not now seek the answers, [...]
The true cost of Facebook: your marriage?
October 10, 2014
Ozy highlights a Boston University study suggesting Facebook is "a positive, significant predictor of divorce rate and spousal troubles." Apparently, Henry David Thoreau* was right about true cost: "The price of anything is the amount of life you exchange for it."
Anne Miller writes (excerpt):
While previous studies suggested that Facebook and its ilk [...]
Who has the power to change your life?
September 15, 2014
CNN celebrated Positive Thinking Day (September 13th) by offering "five expert tips to help you think yourself well." The point is to take responsibility for your happiness and to do something.
Sara Cheshire included these tips (excerpt):
Be aware of your automatic reactions
Catch and reframe your thoughts
Don't believe everything your mind tells you
Let go of fear
Find [...]
Who do professionals recommend as one of the best divorce lawyers and divorce lawyers in Grand Rapids?
August 18, 2014
Best Lawyers in America announced that once again, David Sarnacki was selected by judges and lawyers as one of The Best Lawyers in America. He was honored in three practice areas relating to divorce litigation and divorce mediation:
1. Collaborative Law: Family Law.
2. Family Law.
3. Family Law Mediation.
Changing minds: Listen, show you understand the other person's side, ask to see your side, suggest another outcome
August 17, 2014
Real Simple suggests how to go about changing someone's mind.
Amy Spencer writes (excerpt):
The essential rule when trying to convert someone is: Don't — at least, not at first. "Just listen," says Dennis Ross [author of "The Missing Peace"] . . . .
. . . After listening, show that you get it.
Next, nudge the other [...]
Top 5 admissions: Are you trying to kill your children?
July 20, 2014
CNN's Kelly Wallace shows how many otherwise good parents admit to choices that put their kids at risk of serious injury and death.
Spilling your guts and other concerns when preparing for divorce
July 13, 2014
Kim Komando adds 5 things to your To Do List when a divorce is coming, as well as an opening warning to think twice before posting to social media. In the column, Komando has tips regarding passwords, social media profiles, personal information, and the kids.
In her introduction, Kim Komando writes (excerpt):
My father used to [...]
Favors make the world go around: "Social wheels" and relationships
July 5, 2014
Psychology Today included an item from Susan Krauss Whitbourne's blog, entitled "How to Ask For a Favor." She offered 7 specific situations commonly involving opportunities for favors, and she identified 4 core principles.
Susan Krauss Whitbourne, Ph.D., explains each of these Four Favor principles (excerpt):
1. Be honest and straightforward. . . .
2. Don't [...]
Forget your perfect offering: The cumulative effect of imperfect parenting
June 15, 2014
On Being includes a post by Parker J. Palmer that, while not intended to focus on Father's Day, applies to parenting: Have the courage to make small contributions knowing that there is a cumulative power in your imperfections.
Palmer writes (excerpt):
[Leonard] Cohen's lyrics [in Anthem] remind me that there is a particular kind of courage [...]
She says, you too can rise
May 29, 2014
Maya Angelou (1928 – 2014), heart, soul and voice of "And Still I Rise."
Best wedding vows: perfect marriage by following science?
April 30, 2014
Psychology Today offers us scientific wedding vows.
Samantha Joel's list includes (excerpt):
1. "I promise to respect, admire, and appreciate you for who you are, as well as for the person you wish to become."
2. "I promise to support and protect your freedom; because although our lives are intertwined, your choices are still yours alone."
Essentials, priorities and lifestyle choices: How to set up a quick budget
April 1, 2014
LearnVest offers a simple budgeting rule to apply instantly to your household. Your take-home pay is allocated among three categories: essentials [50%], priorities [20%], and lifestyle choices [30%].
Laura Shin writes (excerpt):
The 50/20/30 Rule can be easy because instead of telling you how to break down your budget across 20 or more different categories (who [...]
A Journey: From nursing to foster caring to parenting to individual adoptions to family
March 22, 2014
Senior Judge Bernard A. Friedman issued his decision after trial in DEBOER v SNYDER, Civil Action No. 12-CV-10285 (E.D. Mich. 2014). He determined that the Michigan Marriage Amendment, a 2004 voter-approved amendment to the Michigan Constitution prohibiting same-sex marriage, is unconstitutional.
The lengthy opinion summarizes the holding as follows (excerpt)[citations omitted]:
In attempting to [...]
What would you do with a $20 bill?
March 8, 2014
CBS highlights superhero Myles Eckert, age 8.
Relationship building: Tips for difficult conversations
March 5, 2014
Today's Love and Logic Insiders Club e-Newsletter featured tips that apply to make difficult conversations in life. The specific context was teacher-conferences, but it noted the interpersonal applications as well.
Charles Fay excerpted some of his father Jim Fay's advice (excerpt):
• Remember that parents who look angry and resistant are usually hurting inside.
• When we remember this, [...]


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subset: commoncrawl


text: There is a growing need to address the situation regarding industry's need of skilled labour and imparting skill development education. But, there is hardly any data on the prevailing status because of which solutions do not exist. This was the general opinion expressed in the first session in the first ever Skillcon India 2013 being held here.


text:
About Schools in Storla, SD
Contact a Coldwell Banker® real estate agent to learn more about the schools and school districts in Storla, SD.FIND AN AGENT
Storla, South Dakota is located in Aurora County. Nearby cities and towns include Letcher, Mount Vernon, Plankinton, Loomis, Woonsocket, Lane, Forestburg, Mitchell, Wessington Springs, Stickney, White Lake, Alpena, and Artesian. Storla is a rural community with a population of 6. The median household income is $0. In Storla, 67% of residents are married, and families with children reside in 33% of the households. Half the population of Storla commutes 3 minutes or less to work, with 0% of residents holding white collar jobs and 0% residents holding blue collar jobs. The median age of homes in Storla, SD is 80 years, with 50% of those homes owned, 25% rented, and 25% not occupied.
Contact a Coldwell Banker® real estate agent to learn more about the schools and school districts in Storla, SD.FIND AN AGENT
See if your personality and goals are right for real estate.SEE ALL REAL ESTATE CAREERS
Community information and market data Powered by Onboard Informatics. Copyright ©2015 Onboard Informatics. Information is deemed reliable but not guaranteed.
This information is provided for general informational purposes only and should not be relied on in making any home-buying decisions. School information does not guarantee enrollment. Contact a local real estate professional or the school district(s) for current information on schools. This information is not intended for use in determining a person's eligibility to attend a school or to use or benefit from other city, town or local services.


text:
Influenza Virus - A Multicenter Registry
The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2012 by University of Alberta.
Recruitment status was Recruiting
Recruitment status was Recruiting
University of Alberta
Information provided by (Responsible Party):
Deepali Kumar, University of Alberta
ClinicalTrials.gov Identifier:
First received: December 6, 2010
Last updated: April 20, 2012
Last verified: April 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study is currently recruiting participants.
|Estimated Study Completion Date:
|December 2013
|Estimated Primary Completion Date:
|May 2013 (Final data collection date for primary outcome measure)


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Hanns.G 28" Monitor + GTX 260 HDMI = FAIL
Well, I just got back from returning my 28" Hanns.G monitor... not a huge deal, but thought I'd pass on the information for anyone else who may be looking at going to something huge.
Basically, this monitor comes with two hookups... analog VGA and HDMI. I have no intention of running my graphics cards on analog VGA, so I hooked up an DVI-HDMI cable and expected everything to run perfectly well... unfortunately, after the post screen everything went wrong.
After a lot of troubleshooting, it seems that recent nVidia drivers (or hardware, or both) recognize anything plugged into HDMI as an HDTV. As we all know, HDTV's are 16:9. Well this Hanns.G is 16:10. When I reduced the resolution to 1920x1080 it worked (though the proportions were off and it wasn't in its native resolution). I tried making custom resolutions etc... but no go. Eventually I just returned the monitor - no harm done.
Anyway, that's my story, use it as you will :) I have read there are registry hacks to get the cards to stop forcing HDTV resolutions over HDMI but I can't be assed to worry about that everytime I update drivers and frequently driver updates break these hacks, so for my own sanity, I'll just wait for a DVI alternative or buy an HDTV.
Re: Hanns.G 28" Monitor + GTX 260 HDMI = FAIL
I run a hannspree 28 inch (basically the same monitor as yours I think, except different stand and more inputs) and I have no problem with my dvi to hdmi cable @ 1920x1200 here.
Re: Hanns.G 28" Monitor + GTX 260 HDMI = FAIL
I'm also assuming here, since you've got a high end system, that you're running fairly recent drivers? I tested the monitor out on my wife's PC with her 7600 GT and 170 something drivers and it worked no problem. I'm running the most recent WHQL which I think are 191.07?
Lastly, does the 285 have a dedicated HDMI out? I require a DVI-HDMI converter to connect, that could be an issue too?
Re: Hanns.G 28" Monitor + GTX 260 HDMI = FAIL
I have to use a DVI-HDMI adapter the one that came with the gtx card.
I'm running 186.39, since I play Fallout 3. I still haven't decided to go to Win 7 yet on my gaming rig, but I do run it both in Snow Leopard with a VM of Win 7 and I have a Win 7 bootcamp install on my Macbook Pro.
Re: Hanns.G 28" Monitor + GTX 260 HDMI = FAIL
Yea that's strange I have the same monitor Hanns-G HG281D and have no problems running at 1920X1200 with the dvi-hdmi adapter. My 295 has a dedicated HDMI port but I didn't have any extra laying around so I just used the adapter, your really not sacrificing anything by using the adapter.
Although Im not running Win7 yet, so maybe the problem lies there...
Re: Hanns.G 28" Monitor + GTX 260 HDMI = FAIL
I assumed Roliath was running Win7 as it was listed in his sig.
Sure is odd, though... but both of you are running newer cards - 285 and 295; my 260's are vanilla purchased as soon as they were available 18 months or so ago. Maybe there's something specific with the hardware or perhaps there was just something wrong with the monitor? I'm considering trying a 32" 1080p television in the future (though I'd rather get a monitor having the tuner features could be useful) so the issue will be nullified anyway.
Re: Hanns.G 28" Monitor + GTX 260 HDMI = FAIL
Re: Hanns.G 28" Monitor + GTX 260 HDMI = FAIL
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May 27, 2015
CINCINNATI (AP) — A southwest Ohio nun who voted on behalf of another nun who died before last year's presidential election has been charged with illegal voting.
The Hamilton County prosecutor in Cincinnati said Monday that Sister Marguerite Kloos (kloos) was among three people charged with voting illegally.
Defense attorney Ralph Kohnen (KOH'-nihn) says Kloos was trying to fulfill the wishes of a friend who died before absentee ballots were mailed. He says she'll plead guilty.
Prosecutors say a man faces the same count after he cast a ballot in November for his late wife.
A poll worker also has been charged with eight illegal-voting counts. Prosecutors say she's charged with voting twice in November and voting for other people in various elections.
Associated Press
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Sorrow and loss are deeply woven into the country music fabric, but they're especially critical elements to the new LP by Jeremy Pinnell, OH/KY. With a gruff voice and a strong grasp on what real country sounds like, Pinnell spins a series of compelling yarns on the album that document the hardships of the past 18 years of his life, from drug addiction to failed relationships. On the cut "Big Bright World", Pinnell takes the former head-on, singing, "I love the needle, son / And the needle loves me / It wants nobody to be free." As Pinnell puts it in describing OH/KY, "You live the life I live, and you will know the way that country sounds." Fortunately, as "Big Bright World" attests, Pinnell's life isn't all loss: "I'm lucky to be in this big bright world", he sings.
OH/KY received a limited Kentucky/Ohio release back in 2014, and is now seeing its national United States release this summer. In his 7 out of 10 review of the album for its limited release in 2014 for PopMatters, Eric Risch calls these tunes "a tutorial on classic country music".


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The Comedy In Fifty Shades of Grey
By Amy Nicholson
Wild Tales Lays Bare Everyone's Awfulness
By Stephanie Zacharek
Approaching the Elephant Is a Bracing Education Doc
By Calum Marsh
By Stephanie Zacharek
By Inkoo Kang
The Results of Our 2014 Film Critics' Poll
By Voice Film Critics
By Alan Scherstuhl
The Blue Room (La Chambre bleue)
By Alan Scherstuhl
"Democracy is messy and nasty and sensational" recalls one of the talking heads in Joan Braderman's spirited doc about the Heresies, the New York feminist art collective that published 27 issues of a journal of the same name from 1977 to 1992. Film- and video-maker Braderman, who joined the collective in 1975, tracks down 24 of her fellow second-wavers (one of whom I worked for briefly 12 years ago), scattered around the globe and ranging in age from 54 to 84, to reminisce about the endless downtown loft meetings and hair-splitting debates about whether "we were Marxist feminists or feminist Marxists"—all part of the collective's mission "to examine every bloody thing in the world." If Braderman's voice-over narration drifts into nostalgia for a lost utopia on occasion, the testimony of her interlocutors reminds us that even though consciousness-raising groups are a thing of the past, the spirit of the group is very much alive, whether in the present-day work of '70s Heretics ("I don't think [second-wave feminism] ever ended," asserts architect Susana Torre) or the commitment of the Gen-Y founders of the feminist, queer LTTR collective. For a movement that was "fundamentally leaderless," Braderman's film gives its participants an opportunity to rightfully claim: "We thought we could change things—and, in fact, we did."
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Alcatel-Lucent Wins Three Awards at LTE North America, Recognizing Excellence in LTE
PARIS, Nov. 16, 2010 /PRNewswire/ — Alcatel-Lucent's (Euronext Paris and NYSE: ALU) leadership in Long Term Evolution (LTE) was recognized by Informa Telecoms and Media, organizers of the LTE world series at the LTE North America 2010 Awards in Dallas with awards in three categories. The company was honored for its work in helping wireless service providers roll out LTE service, for introducing the best network/device testing product of the year, and for the work it is doing to make the technology more environmentally friendly. The specific awards included:
- Significant Progress For a Commercial Launch of LTE by a Vendor in the North America Region
- Best Network/Device Testing Product for LTE (Alcatel-Lucent 9900 Wireless Network Guardian)
- Best Green LTE Product or Initiative in North America (Alcatel-Lucent LTE RAN, Alternative Energy Program and Bell Labs GreenTouch(TM) initiative)
LTE is a fourth generation wireless technology being developed and deployed to enable high-speed transmission needed for such advanced services as mobile, high-definition TV, video streaming and high-speed data downloads. The LTE North America Awards recognize and celebrate excellence in the LTE industry.
"What is particularly exciting is the range of categories in which we were recognized," said Ken Wirth, President, 4G LTE Solutions for Alcatel-Lucent. "As we have always said, LTE is all about end-to-end, and delivering a total value proposition to our customers that goes way beyond the radio network. I think the diversity of awards we received speaks loudly to the company's strength as an end-to-end LTE player."
Alcatel-Lucent was the only company in the awards competition to be shortlisted in six out of nine categories and to receive awards in multiple categories.
The categories in which Alcatel-Lucent won are:
Significant Progress For a Commercial Launch of LTE by a Vendor in the North America Region
Recognizes the vendor for excellent in a commercial rollout of LTE in North America, including trials, commitment and investment in LTE development, as well as customer contracts awarded in North America.
Alcatel-Lucent integrates and delivers a true end-to-end LTE solution that will transform the way that consumers communicate, collaborate and interact with other people, businesses and even machines, while enabling service providers to lower their total cost of ownership and unlock new business models.
Having been selected so far by seven customers for commercial deployments and being involved in 58 trials worldwide, Alcatel-Lucent is a market leader in LTE. The company has been awarded commercial contracts (publicly announced) in North America by the early adopters of LTE, including two of the largest operators in the world, AT&T and Verizon Wireless, and is helping evolve from both CDMA and GSM/HSPA technologies to LTE.
Alcatel-Lucent's LTE solution is already in the field for a large scale commercial launch in 2010 with Verizon Wireless. The company is the unique end-to-end partner of Verizon selected across all strategic areas of their LTE network: Radio Access, Evolved Packet Core, IP Multimedia Subsystem (IMS), backhaul solution and services. Verizon has picked Alcatel-Lucent for the high quality of its solution that translates into the high quality of service.
AT&T has selected Alcatel-Lucent for its Industry-leading Converged RAN W-CDMA/ LTE base stations, Element Management Systems (EMS), Services, 9900 Wireless Network Guardian and most recently mobile backhaul solution as one of the first awards within the IP/MPLS/Ethernet/Evolved Packet Core Domain. Alcatel-Lucent also is providing professional services for the backhaul network.
Alcatel-Lucent is also supporting both the Verizon Wireless and AT&T Innovations Centers.
Alcatel-Lucent is the end-to-end LTE partner of mobile service providers worldwide with the industry's most comprehensive solution (combining IP and LTE leadership, IP transformation and integration experience and a rich and open ecosystem of devices, applications and content).
For more information about Alcatel-Lucent's end-to-end LTE solution, visit: http://lte.alcatel-lucent.com
Best Network/Device Testing Product for LTE (Alcatel-Lucent 9900 Wireless Network Guardian)
Recognizes network and/or device testing products that are exceptional based on how it is used in North America and what the impact has been to measure true LTE performance in real life conditions.
The Alcatel-Lucent 9900 WNG enables wireless service providers to monitor in real-time their 2.5G, 3G and 4G multi-vendor wireless data networks from the RAN to the core (end-to-end). The WNG is deployed in a number of wireless service providers' network
For more information about Alcatel-Lucent's 9900 Wireless Network Guardian, www.alcatel-lucent.com/WNG.
Best Green LTE Product or Initiative in North America (Alcatel-Lucent LTE RAN, Alternative Energy Program and Bell Labs GreenTouch(TM) initiative)
Recognizes work that is being done to make LTE more environmentally friendly in North America.
Alcatel-Lucent's Alternative Energy Program is helping service providers quickly and cost-efficiently deploy wireless networks even to areas not served by electrical power, including all climates and geographies. Over the next two years, Alcatel-Lucent anticipates applying the program to more 100,000 mobile base stations in North America. In addition, Alcatel-Lucent has a strong LTE small cell strategy that enables service providers to reduce the emitted power per site, as well as a converged RAN strategy enabling technologies, including LTE, to run in parallel on the same radio, avoiding heat dissipation, extending life time of the products and reducing waste. Alcatel-Lucent's research arm, Bell Labs, initiated the launch of GreenTouch(TM) a global consortium whose goal is to dramatically improve the energy efficiency of communications networks.
For more information on Alcatel-Lucent's Green initiatives, go to web site: http://www.alcatel-lucent.com/eco.
About Alcatel-Lucent
Alcatel-Lucent (Euronext Paris and NYSE: ALU) is the trusted transformation partner of service providers, enterprises, strategic industries such as defense, energy, healthcare, transportation, and governments worldwide, providing solutions to deliver voice, data and video communication services to end-users. A leader in fixed, mobile and converged broadband networking, IP technologies, applications and services, Alcatel-Lucent leverages the unrivalled technical and scientific expertise of Bell Labs, one of the largest innovation powerhouses in the communications industry. With operations in more than 130 countries and the most experienced global services organization in the industry, Alcatel-Lucent is a local partner with a global reach. Alcatel-Lucent achieved revenues of Euro 15.2 billion in 2009 and is incorporated in France, with executive offices located in Paris. For more information, visit Alcatel-Lucent on the Internet: http://www.alcatel-lucent.com, read the latest posts on the Alcatel-Lucent's blog http://www.alcatel-lucent.com/blog and follow us on Twitter: http://twitter.com/Alcatel_Lucent.
SOURCE Alcatel-Lucent


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is it wrong being a Lesbian?
« Next Previous » Category: love Confessions
Posted by ajvega
on August 15th, 2012 at 12:16 AM
besides, my parents won't let me have a boyfriend. if a boy comes to my house, they will ask "who is he?" "what does he want?" that's kinda annoying. and if my family know that i like girls, they'll mad at me.
my question is... is being lesbian wrong??
3 Comments (add your own)Sort By
there is nothing wrong with being lesbian. If you are happy with a girl be with a girl!!! :D
Yah thats true juzt be urself and be happy.:-)
You're fine. You just need to hang with like-minded folks. More power to you. Be happy. (Sorry for the platitudes, I can't seem to think of anything original right this moment.)
Itz better 2 hide it 1st 2 urself, then wen the rightime c0mez, ur family will surely understant it... Be pr0ud 4 who u are :-)
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|Separate WC's
|Property type
|Minimum Stay
|3 - 7 nights
'The Loft' is a truly amazing penthouse. It is totally unique, and designed to a luxurious specification. With two en-suite bedrooms, a magnificent 100m2 private roof terrace with hot tub, stunning sea & mountain views, and huge shady balcony spanning the entire width of the property, it is the premium property in Makrigialos. The only 90m2 penthouse at Bayview, it accommodates up to six comfortably. The master double bedroom with en-suite, the second double/twin bedroom with en-suite, with another full-size double fold-down bed built-in to the living room wall. Both bedrooms have fully independent air conditioning, as does the enormous open plan living and dining area. The entire property has been fitted out to the highest standards with marble floors, travertine & glass surfaces, and has a contemporary, design led interior. Every attention to detail has been paid to make this stunning property the epitome of luxury accommodation. The kitchen includes a dishwasher & washing machine, and of course coordinating appliances and fittings. The main balcony is fully furnished with stylish furniture & is fronted by a glass balustrade that maximises the incredible views from the main living area and the master bedroom. The second bedroom has it's own private balcony, and there is another balcony from the kitchen. The roof terrace has been fully furnished to offer an enormous private area for sunbathing, dining, relaxing, and of course enjoying the hot tub. Sitting in the hot tub at night, with a cool drink, looking over the sea and mountains is magical. The living area has a flat screen LED TV with X-Box, and a large library of current DVD's. Bring your iPod or iPhone as there is an iPod dock music system (you'll need your own converter for an iPhone 5). Both bedrooms have hair dryers, and stylish beach towels are included to save weight and space in your suitcases.
My husband Steve and I live in the UK and have two teenage daughters. We own and run two businesses, one in the construction industry, and another in interior design. Our aim for The Loft has always and will always be to offer our guests the highest standard of luxury rental accommodation that we look for ourselves whenever we travel. We take great pride in what we offer to our clients and we strive to present the property to the highest possible standard. The Loft showcases my passion for interior design, and is very much our house in Makrigialos as well as a property available for rent, which is why it has been designed to be luxurious & individual, and not a generic rental property.
Steve & Julie Philpot purchased this apartment in 2013
The Loft is the second of our properties at Bayview. We bought a Townhouse in 2009 that we also offer for rent. Because of it's success we wanted the opportunity to offer the most prestigious property at Bayview and we hope we have achieved this. The reasons we chose to own property here are simply that Makrigialos is a truly magical place; the views from our properties are just unbelievable; and the combination of style and available amenities offered us everything we wanted for ourselves and our guests.
The Loft is the only property of it's type at Bayview, in size, layout, and finish. The roof terrace has to be seen to be appreciated, even after you have seen the photographs.
The images on the website raised our expectations, which is always a danger, however we were certainly not disappointed, the apartment was exactly how it looks fantastic! The kids especially liked the swimming pools!
Booking the appt with Steve and Julie was a breeze, they were both very responsive and helpful.
Makrigialos itself is a great location, not too touristy but still enough bars and restaurants to ensure you can eat and drink at a different place every night if you want to. We especially liked Olympio bar for lunch or to use the beach facilities, diskari beach and taverna for a day at the beach with hammocks and both dragons cave and Petra bay were our favourite restaurants, but its fair to say we didn't have a bad experience anywhere.
Overall a great holiday, we will be back.
The apartment looked lovely in the photos and lived up to our expectations. the furnishings are all of excellent quality and very tasteful. It is certainly an apartment with a lot of style and was a pleasure to return to after a long hard day on the beach. The town is about a 5 min easy drive away and there were plenty of restaurants to choose from. The beach was good with nice sunbeds and wine delivered to you from the nearest restaurant while you sunbathed - perfect :-) The communication process in booking our holiday was painless and efficient...We would recommend The Loft to anyone looking for a bit of luxury...!
The Loft lived up to all of our expectations and more. From the information and photos pre booking and arranging the holiday, to our arrival and subsequent weeks holiday everything was exactly as outlined and expected.
The apartment is spacious, stunning and well equipped. It is really accessible and has fantastic views and awesome evening sunsets from the roof terrace. So much so that we spent every evening cooking and enjoying the roof facilities to the full.
The apartment is ideally located for the surrounding coastline and some great little coves and beaches and we were very sad to leave having had a fantastic weeks break and look forward to a future visit.
Staying at the loft was an absolute pleasure. Julie's interior design decor and furnishing is excellent, the photographs do not do this home justice. The apartment is spacious and very comfortable and everything is of a high standard. The roof terrace is enormous with luxurious touches such as the hot tub, barbecue, giant bean bags and amazing views. The complex is peaceful, you need a car to get to the town. There are 2 almost empty beaches on your doorstep and a busier one in town.
We visited the restaurants Steve and Julie recommended and found the food to be of a good standard.
The support Steve and Rosemary provided was second to none and we would have no hesitation in recommending the beautiful accommodation for a truly luxurious holiday.
On a whim I decided that despite having never traveled or driven abroad alone, I needed a breather. I contacted Steve/Julie on the Saturday and arrived the next day. To say they were outstanding in both their response to the initial enquiry and the multitude of emails I sent is an understatement. Nothing was too much trouble. I was given details of car hire, places to visit/eat, directions to the house, arrangements for key pickup. Everything I needed to ensure I arrived safely (which thankfully I did)
The villa itself is breathtaking. Beautifully furnished with everything you'd need for a relaxed stay. Even a welcoming bottle of wine, beer, milk and choc ices.
You will need to hire a car whilst there as it's not walking distance to anywhere but that was the charm in choosing it in the first place. Seclusion, quiet and a beach within 5 mins walk. There is also another beach less than 5 mins drive that has a taverna alongside.
As a rule I don't usually write reviews but in this instance Steve and Julie deserve a glowing review. The accommodation, location, assistance given was first class and worth every penny.
I for one, will certainly return with a smile.
Well done. For my first ever solo trip, it was an amazing success and one I'll look back on with fond memories in years to come.
Bea x
On the South East coast of Crete, with a mountain backdrop, Makrigialos benefits from a micro-climate giving it the best weather on the island. Makrigialos has a small, lively harbour that comes alive at night with numerous local restaurants and cafes serving the freshest local food. This is not an area that is commercialised or abounds with nightclubs. If you want a taste of the real Crete, this is for you. The area is famous for the production of the finest olive oil in the world. The natural beauty of the coast is simply staggering with deserted coves and bays seemingly round every turn. Local waterside tavernas welcome you with cool drinks and delicious food. The nearest towns of Ierapetra and Sitia both have bustling water fronts with cafes spilling out onto the promenades. Both have good shopping, but if you want to go a step further, Heraklion offers shopping to international standards. The area offers all manner of activities & water sports. Spinalonga is well worth a day trip.
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Event Price
Low Season
30 Mar 2015 - 29 May 2015
3 night minimum stay
for 3 nights
Mid Season
30 May 2015 - 10 Jul 2015
3 night minimum stay
for 3 nights
High Season
11 Jul 2015 - 4 Sep 2015
7 night minimum stay
for 7 nights
Mid Season
5 Sep 2015 - 4 Oct 2015
3 night minimum stay
for 3 nights
Autumn Season
5 Oct 2015 - 29 Nov 2015
3 night minimum stay
for 3 nights
Winter Season
30 Nov 2015 - 4 Mar 2016
3 night minimum stay
for 3 nights
|No additional mandatory fees
|Refundable Damage Deposit
Deposits are non-refundable, but in the event that you have to cancel, you may be able to reclaim this on your holiday or travel insurance.
The advertised rates are subject to change at our discretion.
30% of the total rental is payable with your booking. The balance is payable 10 weeks before the start of your holiday.
A refundable security deposit of £200 is required to be paid with your final balance. It will be refunded to you once the property has been inspected by our housekeeper.
Please Note: The owner of this property accepts payment in the original currency specified (GBP), before use of conversion tool. The conversion tool is provided for your convenience only. The owner may accept other currencies if specifically agreed in advance.
Learn more about this holiday rental at the owner's website:


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Arkansas governor vetoes 20-week abortion bill
The House approved Mayberry's bill on an 80-10 vote last week. It had been previously approved by the Senate on a 25-7 vote.
Abortion rights advocates who had gathered at the Capitol cheered when Beebe's decision was announced.
"I am very grateful that the governor understood that it's not reasonable for the government to interfere with these very private and complex medical decisions that a woman needs to make with her doctor and with her faith and with her family," said Jill June, president and CEO of Planned Parenthood of the Heartland. "The decision to end a pregnancy is one of the most complicated decisions a woman will make in her life."
The bill marks the 11th time Beebe has vetoed legislation since taking office in 2007.
Beebe, who is serving his second term, has backed some abortion restrictions, including a bill signed earlier this month that bans insurers participating in the exchange created under the federal health care law from covering most abortions. Two years ago, he signed into law a proposal placing new regulations on the clinics that offer the abortion pill and in 2009 he signed legislation that mirrors a federal law banning late-term abortions.
Beebe wouldn't say whether the decision means he'd veto the 12-week ban pending before lawmakers.
"I'm pretty sure I know what I'm going to do on a bill that's even more problematic than the one I already vetoed, but I won't tell you officially until that time," Beebe said.
Associated Press Writer Michael Stratford contributed to this report.
Andrew DeMillo can be reached at www.twitter.com/ademillo
The Associated Press


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You may have heard of Blaise Pascal famously ending a correspondence to a friend with "I have made this letter longer than usual, only because I have not had time to make it shorter." Many writers identify with this because they understand how much time and effort is needed to convey complex meaning in few words. I'm no designer, but I'd imagine they face similar challenges when conveying meaning with minimal visual elements. At least that's what I thought of when I saw this series of minimalist posters for fairy tales. Scroll slowly and see if you can guess the tale with just he image.
Minimalist story telling
3 Comments
I love these! The three little pigs is especially nice. You need the context of the story to understand, but with that it tells the whole story. I may need to adapt the swirly Rumpelstiltskin R for an emblem.
The subtle texture in the backgrounds is also very nice.
And, I'm in favor of the color palette.


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Mar 29, 2012
French gunman's body may be sent to Algeria for burial
The father of an al Qaeda-inspired gunman who killed seven people in a shooting rampage in southwest France said on Wednesday he wanted his son buried in Algeria, but the Algerian authorities had yet to agree to receive the body. #Al-Qaeda #France #NewsTracker #Paris #Algeria #Toulouse #Mohamed Merah
Mar 22, 2012
France Police standoff with terror suspect enters second day
The standoff in Toulouse has entered its second day, pitting a holed-up suspected gunman behind an al-Qaida-linked killing spree against hundreds of French police working to arrest him. #NewsTracker #Toulouse #Mohamed Merah #French police
Mar 22, 2012
French gunman showed no sign of militant leanings
The 24-year-old Frenchman of Algerian descent was holed up in his apartment after exchanging gunfire with police. #NewsTracker #Toulouse #Mohamed Merah #French Jewish School killings
Mar 22, 2012
French police use explosions to get school gunman to surrender
Riot police set off explosions outside an apartment building early Thursday in an effort to force the surrender of a gunman who boasted of bringing France "to its knees" with an al-Qaida-linked terror spree that killed seven people. #France #NewsTracker #Toulouse #Mohamed Merah #Jewish School Killings in France
Mar 21, 2012
Jewish school killer refuses to surrender
French police officers are raiding a house in the southern city of Toulouse in the search for a gunman suspected of killing three Jewish schoolchildren, a rabbi and three paratroopers in three separate attacks. #Al-Qaeda #NewsTracker #Toulouse #Jewish school gunman


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Welcome to my website! Consider this site your comprehensive source for valuable real estate information, including up-to-date local property listings and home evaluation tools for the entire Hampton Roads region.
In today's ever-changing real estate market, whether buying or selling, you need a professional who understands current real estate trends and focuses on your needs. That's where I can help. Not only am I a member of the National Association of REALTORS®, and the Virginia Association of REALTORS®, but I'm also an expert in the local Virginia Beach real estate market. My clients will tell you that I deliver exceptional service and impressive results.
For buyers, I take advantage of the latest technology to keep you informed about properties that meet your search criteria. With our innovative technology you'll be the first to learn about new listings — many times, even before other real estate agents! Because I'm an ABR (Accredited Buyer Representative) you can rest assured that I'll always represent your best interests and that together we'll find the home of your dreams.
For sellers, I use the same groundbreaking technology to exposure your property to potential buyers. As a Listing Specialist and Home Marketing Expert, not only will I list your home — I'll SELL it! I post your home on national property search websites, driving buyer traffic back here to my Virginia Beach real estate website. When these potential buyers visit my site, I capture their contact information and touch base with them to gauge their interest in your home and to schedule a showing.
Are you ready to get moving? Call, text, or email me today!
Art Caccese
Broker | Director, Luxury Homes Division
From the Blog: Pricing Your Home to Sell
I've learned a great deal the last eight years selling hundreds of homes all over Coastal Virginia. By helping homeowners to market and sell their homes, I've discovered three factors that determine whether a home sits or sells. 1. PRICE the home right from...
A recent study has concluded that 39% of buyers prefer to rent out their last residence rather than sell it when purchasing their next home. The study cites that many homeowners were able to refinance and "locked in a very low mortgage rate in recent years. That...


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Trellises and arbors lift up your garden
While you're plotting and planning your landscape over the winter, you might consider the addition of a trellis, which can range from a simple arc made from bent wood to an impressive arbor made with 6-by-6-inch posts. It all depends on what you want and how much space you have.
Going vertical is a great option for small spaces, and you have your choice of myriad materials and sizes. Trellises come ready made or you can get in touch with your inner Bob the Builder and do it yourself.
Be mindful of what you plan to grown on this trellis. I have two clematis and will be getting larger trellises over the winter. Those pretty, 4-foot-tall numbers are not getting the job done. Those may become yard art.
Also, consider how heavy the mature plant will be. Wisteria needs extra heavy-duty support, while sweet peas can grow on a willow teepee. Large arbors can accommodate a bench below them if you're so inclined, but whatever the size, you are basically erecting four posts with a top structure. These work for the heavy weight climbers in the plant world. You can also use it to grow climbing members of the vegetable set.
The materials you choose to build from or purchase are as varied as the plants you can choose to climb on it. I saw a picture on Pintrest of a scrollwork trellis made from barbed wire. It was beautiful. Having worked with barbed wire, I know the person who made that trellis worked darn hard to get that done.
You can spend as much or as little as you want. Of course I have a book about building your own, "Sunset's Trellises and Arbors." It has several ideas with easy-to-follow instructions along with material lists, which are very helpful. One of the projects uses rough-hewn logs and that's given me an idea that involves some of the mesquite out here. There's also repurposing. I've decided that old door I have in the garage is going to become part of a trellis. I have a friend whose husband has made an arbor from an old satellite dish and other salvaged material and it looks so cool.
Get creative, look around you and see what you can keep out of the landfill. That junk can beautify your landscape!
Send your gardening questions to email@example.com or go to www.txmg.org/wichita and use the contact form.
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Need Help? Call us at 1-877-710-6181.
Monday-Friday: 5:30am-8pm / Saturday: 6am-1pm / Sunday: 6am-1pm


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Scroll Down
Come Work For Warmerdam Packing
Warmerdam Packing is looking for workers for the cherry season. Apply online anytime starting March 9th.
Excelsior Farming Employment Opportunities
Excelsior Farming is a sister company to Warmerdam Packing. Excelsior Farming farms Cherries, Nectarines, Peaches and other fresh fruits. Excelsior Farming is looking for workers for their 2015 season with several positions available. Keep visiting our web page for further updates.


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- Evening Wine Hour
- Free valet parking (value of $60 per night)
- Good for stays through April 6, 2015
Get complimentary parking in NYC when you book the drive in and stay parking deal at the Dumont NYC, your home away from home. Located on 34th Street in Midtown East, our hotel offers parking for guests and is just steps away from famous shopping, sightseeing and lively restaurants.
The Drive In and Stay NYC parking deal includes daily valet parking (value of up to $60 per night), complimentary Wi-Fi when booking on Affinia.com, and evening Wine Hour in the lobby from 5-6 PM.
All rooms come complete with a full kitchen and Skyline Suites offer the most stunning cityscapes of all, overlooking the Chrysler Building, the Freedom Tower or the East River.
Available for stays through September 14, 2015. Book now and mention promo code DRIVNY.
Enjoy great savings with this non-refundbale offer. Package includes valet parking each night you stay, valued at $60 nightly. No in and out privileges.


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Upload photos, chat with photographers, win prizes and much more for free!
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Hi Thankyou for taking the time to look at my portfolio i'm an amateur who loves fashion and portraiture as well as the odd landscape, i'm continually learning and finding my direction so if you have any constructive comments or advice please feel free to leave it and if anyone would like to buy me a 5D then that would be a bonus lol
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SOAR I: July 24-25, 2015
SOAR II: July 27-28, 2015
SOAR III: July 29-30, 2015
SOAR IV: August 27-28, 2015*
Register for SOAR
To register, please click on a session below:
*Priority registration reserved for students outside of Minnesota and eastern Wisconsin, call Orientation Programs at 612-330-1100 for more information.
The SOAR registration deadline is Friday, July 10, 2015!
What is SOAR?
Summer Orientation and Registration (SOAR) is a required two-day overnight orientation experience for all incoming first-year students who will be starting at Augsburg College in fall 2015. SOAR is designed to help with the transition to Augsburg and allows students to register for fall classes; meet fellow classmates, faculty and staff; learn about college resources and services; explore the campus and surrounding community; obtain an Augsburg College student ID; and get a taste for life on campus.
Are students required to attend SOAR?
SOAR is required for all incoming first-year students who will be starting at Augsburg College in fall 2015.
What do students need to do prior to attending SOAR?
Academic Advising will be reaching out to incoming first-year students in June and July to review any placement tests in writing, math, or language that are needed before and during SOAR. Academic Advisng will also help students activate their Augsburg email accounts and prepare students for selecting and registering for their fall classes at SOAR. For questions or concerns, please contact Academic Advising at
email@example.com or 612-330-1025. For more information, please visit augsburg.edu/advising.
What should students bring to SOAR?
- Alarm clock
- Calculator for Math Placement Test (graphing
calculator okay)
- Comfortable walking shoes*
- Comfortable weather-appropriate clothing
- Fan
- Notebook
- Overnight items/toiletries
- Towel and washcloth (bedding and linens
- Umbrella
*Students will be exploring different communities, businesses, organizations, and campus partners surrounding the Augsburg College campus and will be traveling varying distances by walking and/or using public transportation.
Are students required to stay overnight during SOAR?
All incoming first-year students who will be starting at Augsburg College in fall 2015 are required to stay overnight on campus during their SOAR session (SOAR I, II, & III only) regardless of their resident or commuter status.
Where do students stay overnight during SOAR?
Students will be staying overnight in Urness Hall, a first-year student residence hall. Please note: Housing is not available on campus for parents or siblings.
Can parents attend SOAR?
SOAR is specifically designed for incoming first-year students and so parents are invited to attend Parent SOAR, an optional two-day orientation experience. Parent SOAR runs concurrently with the student SOAR sessions (SOAR I & II only). There is also an Evening Parent SOAR option available for those parents who cannot attend one of the two-day Parent SOAR sessions but who still want to participate in orientation. Parents should go to augsburg.edu/cao/orientation/parent-soar to complete an online registration form and then choose from one of the following three sessions:
- Parent SOAR I: July 24-25, 2015
- Parent SOAR II: July 27-28, 2015
- Evening Parent SOAR: July 28, 2015
The Parent SOAR and Evening Parent SOAR Registration Deadline is Friday, July 10, 2015!
Can siblings attend SOAR?
Unfortunately there is no programming available for siblings during SOAR, Parent SOAR, or Evening Parent SOAR.
When and where do students check-in for SOAR?
Check-in and other pre-orientation activities will take place between 8:00-8:45 a.m. on Day 1 of each SOAR session in the Christensen Center Lobby. Required SOAR programming will conclude by 1:00 p.m. and optional SOAR programming will conclude by 2:30 p.m. on Day 2 of each SOAR session.
Where can students park during during SOAR?
Students can park free of charge in any designated Augsburg College parking lot during the hours of their SOAR session. A map of parking lots on campus can be found at augsburg.edu/about/map.
Need accommodations?
To request accommodations for a disability, such as print materials in electronic formats, housing needs, physical access/mobility issues, etc. for SOAR, please contact the Center for Learning and Accessible Student Services (CLASS) at firstname.lastname@example.com or 612-330-1053. For more information about CLASS Disability Services, please visit augsburg.edu/class.
Additional questions?
Please contact Campus Activities and Orientation (CAO) – Orientation Programs at email@example.com or 612-330-1100 for all questions and concerns regarding SOAR.
Auggie Days, the second part of the required orientation experience for first-year students, starts Friday, August 28 and runs until Friday, September 4, 2015. (Aug. 28-31 is required Auggie Days programming and Sept. 1-4 is optional Auggie Days programming.) STUDENTS SHOULD MARK THEIR CALENDARS!
Please note: Once students register for their SOAR session, they are automatically registered for Auggie Days. For more information about Auggie Days visit augsburg.edu/cao/orientation/auggie-days.


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'Downpour' at 371
Francis Bejar, Chalk Zaldivar and the Gerilya art group explore the space between the ethereal and the metaphysical at the inaugural exhibition of 371 Art Space at The Collective complex in Makati.
In "Downpour," these artists answer the metaphysical question of what lies between the real and unreal through a mixed-media presentation of flat paper, wood and canvas works and installation pieces. From the flow of these artists, the conceptual nous of reality and dream are explored through their shared perplexity.
Bejar, winner in both the sculpture and painting categories of the Shell National Student's Art competition, works with a frame of a world diluted by media images.
Using familiar images derived from local pop culture, Bejar exacts the skilled brushwork. He successfully blends figure and surrounding patterns revealing the enticements of a painter who wants to both disclose his message and be absurd about them.
Zaldivar's acrylic paintings on wood panel link art and childhood in powerfully imaginative manner. At once cool and miserable, his illustrations of men and women in patterned robes or suits suggest a profound doubt into commonly held belief that viewers get to know artists through their works.
Zaldivar's brand of pop-culture imagery eludes the stiffening action that fuels Japanese Manga comics, or even the stills chosen by the likes of Yoshitomo Nara, Warhol and Lichtenstein. His works in this exhibition, for instance, are spare drawings done with a palette of pale colors. One may read his works as harmless kindergarten décor or as slightly monstrous and disturbing. The cartoony figures and confining dumbness of his imagery are aimed at producing a subtle destabilizing effect of anxiety. Zaldivar's works have been finalists at the Shell National Student's Art Competition.
Gerilya is a six-artist collective formed in 2008. Its three original members, Jano, Kube and Zap, hail from the College of Fine Arts at University of the Philippines. Gerilya is involved in various experimental ventures such as comics, street art, graffiti animation, fine-art exhibitions and illustration commissions. Their work is inspired by Philippine culture and history, exploring socio-political issues and national identity. They seek to make their art as relevant as possible by drawing influences from Philippine popular and mass culture.
371 Art Space is at The Collective, 7274 Malugay St., San Antonio Village, Makati City; tel. 7278182; e-mail firstname.lastname@example.com; visit www.371artspace.com. Exhibit runs until Dec. 29.
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1960-1970's Wind Direction Indicator
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1960-1970's Wind Direction Indicator
Good evening everyone,
I've been searching up and down the internet for some information regarding a wind direction indicator created or distributed by M. C. Stewart Co.
This company is no longer in business, probably for a couple decades now, I've tried searching anything I can about this company and their products. Sadly I cannot find even the slightest bit of info besides the address and phone number which no longer works.
However, I did find a picture of the wind direction indicator box I currently own, it can be found by going to this link and word searching "M. C. Stewart"
Hawaii: Perspectives on Hamakua History: Ramblings Through an Ancient Land ... - Prosper Quentin Tomich - Google Books
The picture is Figure 5.
For a better description, This box is stained and encases a 9 bulb system that lights up through telephone / telegraph signals. The 8 bulbs that circle on this case references North, North-East, East, South-East, etc. This box I'm also guessing is the Receiver end of the whole system.
The 9th bulb is in the middle and I'm assuming it tells you if it's on/off.
I've read that it can also predict rainfall.
It's been stamped on the back as well as the front "Made in U.S.A, M. C. Stewart Ashburnham Mass
Thank you for your time.
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New Bedford Mass-Cobb Island MD
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Wind and pie move my boat.
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It's anything but an amazing story . It's an idiot story & a fool's errand , but I have been as touched by folks in this forum refraining from observing the moronic & feeling compelled to point out the obvious , as I have been from their concerned & well intentioned advise . 8 years ago I was mauled by a sow bear with 2 cubs at a backwoods cabin 8 miles from the trail head & had to make my way in the dark back out to the trail head & then drive 80 miles for medical attention . I find the task presently before me much more daunting . It would seem the only viable tool I have to bring to the table is a will . I haven't the words to express my thanks to the folks in this forum .
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Welcome to St. Edward's School Website.
If you have a child who is already attending our school we thank you for the confidence you have shown in us by choosing St. Edward's. We hope to maintain the close links that already exist between us.
If your child is to join us for the first time we extend a warm welcome to you and look forward to a happy and successful partnership during the coming years. Partnership with parents has long been a principle embedded in Catholic Education and one, which we truly value.
We hope you will find this website interesting and that it will give you all the information you need about our school.
We believe that we are a happy, caring and successful school, built on mutual trust and understanding between home and school.
Please see our latest RE Inspection Report on our 'Prayer Life' page.
Mr T J Hughes


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We examined the association between single nucleotide polymorphisms (SNPs) in loci encoding surfactant protein A (SFTPA) and risk of wheeze and persistent cough during the first year of life among a cohort of infants at risk for developing asthma.
Between September 1996 and December 1998, mothers of newborn infants were invited to participate if they had an older child with clinician-diagnosed asthma. Each mother was given a standardized questionnaire within 4 months of her infant's birth. Infant respiratory symptoms were collected during quarterly telephone interviews at 6, 9 and 12 months of age. Due to the association of SFTPA polymorphisms and race/ethnicity, analyses were restricted to 221 white infants for whom whole blood and respiratory data were available. Ordered logistic regression models were used to examine the association between respiratory symptom frequency and SFTPA haplotypes.
The 6A allele haplotype of SFTPA1, with an estimated frequency of 6% among our study infants, was associated with an increased risk of persistent cough (OR 3.69, 95% CI 1.71, 7.98) and wheeze (OR 4.72, 95% CI 2.20, 10.11). The 6A/1A haplotype of SFTPA, found among approximately 5% of the infants, was associated with an increased risk of persistent cough (OR 3.20, 95% CI 1.39, 7.36) and wheeze (OR 3.25, 95% CI 1.43, 7.37).
Polymorphisms within SFTPA loci may be associated with wheeze and persistent cough in white infants at risk for asthma. These associations require replication and exploration in other ethnic/racial groups.
Wheeze and persistent cough in infants are serious respiratory symptoms that can be triggered by respiratory infections and/or a variety of environmental exposures [1-3]. Surfactant protein A (SFTPA) is an abundant, multifunctional protein that is secreted by airway epithelial cells and functions as part of the innate immune response. SFTPA may be critical in protecting the lungs from infectious agents and environmental exposures early in life before the acquisition of specific immunity. SFTPA neutralizes respiratory viruses such as influenza and respiratory syncytial virus (RSV) [4,5]. SFTPA also enhances the uptake of bacteria and viruses by phagocytes [6-8]. In addition to its role in protecting the lungs from microorganisms, SFTPA has other important immunomodulatory functions including binding aeroallergens [9].
SFTPA's role in protection of the lungs has led to exploration of potential links between SFTPA and diseases of the respiratory tract in infants and young children. Polymorphisms within SFTPA1 and SFTPA2, two functional, highly homologous SFTPA genes [10-12] have been linked to respiratory distress syndrome in infants [13-15], severe RSV bronchiolitis [16], and otitis media [17,18]. In the present study, we used a candidate gene approach to investigate whether polymorphisms within the SFTPA1 and SFTPA2 genes were associated with wheeze and persistent cough during the first year of life among a prospective birth cohort at risk for developing asthma.
Between September 1996 and December 1998, we invited women delivering babies in six hospitals in Connecticut and Massachusetts to participate in a longitudinal study of asthma development if they had at least one other child at home under 12 years of age with physician-diagnosed asthma. Infants enrolled in the cohort were considered at risk for asthma due to their asthmatic siblings. We provide a full description of the methods elsewhere [2,19].
Of the 1,002 infants originally enrolled, respiratory symptom data were available for the first year of life for 889. Between the third and fifth year of participation, we made a second visit to the home to collect a blood sample from our cohort subjects. The current analyses are based on a convenience sample of 355 for whom whole blood and complete respiratory symptom data were available. Nucleotide changes at amino acid (aa) 19, aa 62, and aa 133 in SFTPA1, and aa 223 in SFTPA2 were significantly associated with ethnicity. To prevent identification of invalid associations due to population stratification, we restricted our haplotype analyses to the ethnic group with the largest number of subjects (221 white infants). The Yale Human Investigations Committee and institutional review boards at each participating hospital reviewed and approved the study.
Data collection
A research assistant visited the home within 4 months of the infant's birth in order to describe the study to the infant's mother, obtain written informed consent, and administer a standardized questionnaire. We collected household demographic data including maternal race and ethnicity, education and number of children; detailed information regarding infant care (e.g. breastfeeding and daycare use); and maternal health status (e.g. self-reported history of allergies or physician-diagnosed asthma). Infant respiratory symptoms were collected during quarterly telephone interviews at 6, 9 and 12 months of age at which time each mother reported on her infant's respiratory symptoms (number of symptom-days per month of wheeze or persistent cough) and doctor or clinic visits (month and year of visit, reason for visit, and diagnosis). Around the time of the infant's first birthday, the mother completed an additional phone questionnaire covering her infant's health status during the previous year.
Genotyping of SFTPA genes
DNA was extracted from whole blood using the QIAamp DNA blood minikit (Qiagen) according to the manufacturer's instructions. We used sequence specific primer-PCR methodology to genotype the SNPs at aa 19, aa 50, aa 62, aa 133, and aa 219 in SFTPA1 and aa 9, aa 91, aa 223 in SFTPA2 [20]. We used PCR based cRFLP as described by DiAngelo et al. [21] to detect polymorphisms in SFTPA2 at aa 140.
Data analysis
Outcomes of interest were respiratory symptom frequency in the first year of life categorized as none or as 1 to 7, 8 to 14, 15 to 21, 22 to 28, or more than 28 days of persistent cough or wheeze. Between 1 and 6 months of symptom information were missing for 18 infants. Data from these infants were included in analyses based on their symptom rates. All other infants had 12 months of complete symptom data. Unadjusted associations between respiratory symptoms and selected study characteristics, SNPs, and individual SFTPA1 or SFTPA2 alleles were evaluated with tests for linear trend (Cochran-Armitage or Somers' D statistic). For statistical tests involving SNPs, frequencies for the minor homozygous allele and heterozygous alleles were combined and compared to the dominant homozygous group. Observed SNP frequencies were tested for Hardy-Weinberg equilibrium by χ2 analyses. We examined pairwise linkage disequilibrium with r2 measures (Fig. 1) using PROC ALLELE of the SAS/Genetics module of SAS version 9.1 [22]. Allele haplotypes for SFTPA1 and for SFTPA2 were assigned and examined for linkage disequilibrium using PROC HAPLOTYPE [22]. We examined the association between haplotype and respiratory symptom frequency (as categorical variables) using ordered logistic regression. Separate analyses were conducted for each symptom and each haplotype compared to all other haplotypes. We estimated the effect of uncertainty in haplotype assignment using a regression calibration technique [18,23] and the SFTPA1 and SFTPA2 haplotype probabilities obtained from PROC HAPLOTYPE. As described previously [18], this technique involved first creating 100 separate haplotype data sets by randomly assigning subject haplotypes based on each subject's haplotype probabilities. Next, 100 separate ordered logistic regression models with coefficient and variance estimates (βi and σi 2 for the ith model) were fit for each haplotype of interest. The estimate of the association between the respiratory symptom and the particular haplotype of interest ( ) was calculated as the mean of the 100 regression models. The variability of the estimate was calculated as
Figure 1. Pairwise linkage disequilibrium measure (r2) for surfactant protein A SNPs (5 SFTPA1 SNPs: aa 19, aa 50, aa 62, aa 133, aa 219; 4 SFTPA2 SNPs: aa 9, aa 91 aa 140, aa 223) from 221 white infants at risk for developing asthma. Gray scale represents strength of association from white (r2 = 0) to black (r2 = 1). (CT and MA, 1998 – 2000)
where mean () is defined as the mean of the 100 logistic regression variances and var (bis) is defined as the variance of the 100 logistic regression b coefficients.
Close to half of the 221 infants in our study experienced persistent cough (51%) or wheeze (46%) during their first year of life (Table 1). Thirty-two percent of the infants experienced from 1 to 28 days of persistent cough, 19% experienced more than 28 days of persistent cough during their first year; 36% experienced 1 to 28 days of wheeze and 10% experienced more than 28 days of wheeze during their first year of life. Male infants and infants of asthmatic mothers were more likely to experience persistent cough and wheeze during their first year of life (Table 1). We did not find significant associations with either persistent cough or wheeze and maternal allergies, age daycare attendance began, number of months of breastfeeding, or exposure to environmental tobacco smoke (ETS).
Table 1. Unadjusted associations between personal characteristics and respiratory symptoms during the first year of life for 221 white infants at risk for developing asthma. (CT and MA, 1998 – 2000)
Table 2 contains unadjusted associations between each of the nine candidate SNPs and persistent cough or wheeze. Individual SNPs were in Hardy-Weinberg equilibrium (p > 0.05 for the χ2 test). Having a C nucleotide at aa 19 in SFTPA1 was associated with greater frequency of wheeze. The G nucleotide at aa 133 was associated with both wheeze and persistent cough during the first year of life. We did not find any significant associations between each of the nine SNPs and personal characteristics listed in Table 1.
Table 2. Unadjusted associations between SNPs from surfactant protein A alleles (SFTPA1,SFTPA2) and respiratory symptomsa during the first year of life for white infants at risk for developing asthma. (CT and MA, 1998 – 2000)
By convention, SFTPA1 and SFTPA2 allele haplotypes are denoted by 6An and 1Am respectively [17,21]. The estimated frequency of each allele haplotype is given in Table 3. The five SNPs in SFTPA1 were in linkage disequilibrium as were the four SNPs in SFTPA2 (p < 0.0001, χ2 test of allelic associations).
Table 3. Unadjusted associations between surfactant protein A (SFTPA1,SFTPA2) haplotypes and persistent cough or wheeze in the first year of life.a Unadjusted odds ratios (OR) and 95% confidence intervals (CI) are from ordered logistic regression models predicting symptom frequency. b (CT and MA, 1998 – 2000)
The most common SFTPA1 allele haplotypes among white infants in our study population were 6A2, 6A3, 6A4, and 6A in order of decreasing frequency. All others made up 8% of the SFTPA1 alleles. 1A0 was the most common SFTPA2 allele followed in order by 1A1, 1A2, 1A, 1A5, 1A6, and 1A3. All others combined made up 4% of the SFTPA2 alleles.
Significant associations were found between specific allele haplotypes and frequency of persistent cough or wheeze during the first year of life (Table 3). The 6A haplotype of SFTPA1 was a risk factor for both persistent cough and wheeze: infants with this haplotype (an estimated 6% of this group of white infants) were 3.7 to 4.7 times more likely to experience an additional week of persistent cough or wheeze, respectively, during their first year than infants without this haplotype.
SFTPA1 and SFTPA2 alleles are known to be in strong linkage disequilibrium [24,25]. This was also true in our population of white infants in a general test of allelic associations (p < 0.0001, χ2 test), although pairwise linkage disequilibrium measures (r2) for SNPs within SFTPA reveal a spectrum of associations from r2 = 0 to 0.6 (Fig. 1). An examination of SFTPA1 and SFTPA2 alleles together indicates that infants with the 6A/1A haplotype, an estimated 5.4% of this group, were over 3 times more likely to experience an additional week of persistent cough and/or wheeze during their first year than infants without this haplotype (Table 3).
Discussion and conclusion
Results from our study suggest that the 6A allele haplotype of SFTPA1 and the 6A/1A haplotype of SFTPA are associated with increased risk for wheeze and persistent cough among infants at risk for asthma. To our knowledge, this is the first study examining the association of polymorphisms in SFTPA with persistent cough and wheeze in infants. Respiratory symptoms may be triggered by bacterial or viral respiratory infections or exposure to environmental contaminants. This is certainly true for children in our birth cohort [2,3,19]. As reported previously [2], among all children in our birth cohort, infants whose mothers reported respiratory illnesses including bronchitis, bronchiolitis, pneumonia, or croup, were 3 to 5 times more likely to experience persistent cough or wheeze in the first year of life than infants who had no respiratory illness in their first year. Among these same infants, respiratory symptoms have also been linked to household exposures such as NO2 [3] and mold [2,19].
SFTPA likely plays multiple pleiotropic roles in the pathophysiology of the lung. Evidence from animal and human studies suggests an important role for SFTPA in protecting infants and young children during microbial infections early in life. SFTPA deficient mice are impaired in their ability to clear adenovirus from the lung [24]. SFTPA knockout mice show delayed clearance of Haemophilus influenzae [25]. Cell culture assays indicate that SFTPA enhances phagocytosis of H. influenzae and Streptococcus pneumoniae [26].
Among infants, polymorphisms in SFTPA have been associated with severe bronchiolitis [16]. The 6A2/1A3 haplotype was associated with increased risk of severe RSV infection (OR 10.4 95% CI 1.3–83.2) and haplotype 6A/1A was protective for severe disease (OR 0.17 95% CI 0.04–0.80). In this study of Finnish infants, cases were hospitalized infants with documented bronchilotis caused by RSV. Controls, matched on sex and age, had no history of respiratory infections requiring hospitalization, but might have had respiratory infections (and symptoms) not requiring hospitalization. Although we identified 6A/1A with increased risk for wheeze and persistent cough, it is interesting that the 6A/1A haplotype is associated with respiratory problems in both populations. Direct comparison between the two studies is difficult because of differences in study design. In our study, "cases" were defined by reported respiratory symptoms. Specific causal agents were not identified, and we did not use hospitalization as a requirement for inclusion. Thus, some of our study subjects could resemble Finnish cases (hospitalized for RSV) or controls (not hospitalized, but possibly suffering from respiratory infection and exhibiting respiratory symptoms).
SFTPA has been shown to bind to aeroallergens including inhalable extracts from the mold Aspergillus fumigatus [27] and from the mite Dermatophagoides pteronyssinus (Der p) [28]. SFTPA has also been postulated to play a role in allergic asthma [29]. A murine model of asthma indicates that SFTPA mRNA and protein levels increase in response to allergen challenge [30]. SFTPA decreases Der p induced lymphocyte proliferation and histamine release from the blood of atopic donors [31]. SFTPA has also been implicated in bronchial inflammation of sensitized mice [32].
All infants in our cohort have at least one sibling with asthma and one-third have asthmatic mothers (Table 1). Two-thirds of the infants have mothers with allergies (Table 1). The children in our cohort experienced high rates of wheeze (46%) during their first year of life (Table 1). Among a cohort of 890 healthy infants in Connecticut and Virginia born between 1993–1996, 33% experienced an episode of wheeze during the winter months of their first year of life [34]. The high rate of wheeze in our study population may reflect the special nature of our cohort: all are considered to be at risk for developing asthma. Along these same lines, SFTPA may play a role in the pathogenesis of asthma, and infants in our cohort, by virtue of their family histories of asthma, may differ in SFTPA1 and SFTPA2 hapylotype distributions compared to the general population. Population based estimates of SFTPA1 allele haplotype frequencies among white Americans are 56.2% 6A2, 24.3% 6A3, 9.3% 6A, 7.6% 6A4 and 2.6% other [33]. Allele haplotype frequencies for SFTPA2 are 53% 1A0, 10.2% 1A, 14.3% 1A1, 7.6% 1A2, and 14.9% all others [33]. With the notable exception of the SFTPA1 allele haplotype 6A, the distribution of SFTPA1 and SFTPA2 haplotypes in our sample of white infants is similar to that of white Americans in the general population. The general population frequency for 6A of 9.3% is higher than the 95% confidence interval for our estimate of 6.1% (95% CI 4.0–8.3), which may indicate a true difference in frequency for this allele haplotype among our group of infants.
The functional significance of specific changes in nucleotide sequence within SFTPA genes has not been well studied. SFTPA is a member of the collectin family and recognizes carbohydrates on the surface of pathogens via their carbohydrate recognition domain [35]. Allele 6A is the only common haplotype in our population with an alanine at aa 19 and a G at aa 133. The SNP at aa 133 is silent, however, aa 19 is in the N terminal region of SFTPA1 and an alanine in this region could conceivably impact binding to pathogens or aeroallergens. Further experiments are needed to identify whether amino acid changes in this region impact the biological properties of SFTPA. Alternatively, the 6A haplotype may simply be a marker for additional uncharacterized functional polymorphisms in our cohort.
Strengths of this study include the prospective study design and the well characterized demographic, illness, and environmental exposure information for the infant cohort. Mothers in this study were likely capable of accurately reporting respiratory symptoms due to their familiarity with wheeze and persistent cough in the older asthmatic child. Haplotype analyses often use the "most likely" haplotype and seldom include adjustments for uncertainty in haplotype assignment. We used regression calibration techniques that incorporate this uncertainty into estimates of the effect resulting in more conservative estimates of the true associations between SFTPA and persistent cough or wheeze during the first year of life.
Our results support the importance of SFTPA in modulating respiratory symptoms in infants. Persistent cough and wheeze may result from a variety of exposures and the multifunctional nature of SFTPA indicates that it protects the lung under a variety of conditions. The 6A/1A haplotype may have a functional role in pathogenic processes, or may be linked to unmeasured markers that are causal. Future studies should replicate these observations and examine polymorphisms within SFTPA among additional racial and ethnic groups.
Competing interests
The author(s) declare that they have no competing interests.
Authors' contributions
MMP conceived of the study, analyzed and interpreted data, and drafted the manuscript. JFG participated in the analysis and interpretation of data, performed the statistical analysis, and helped revise the manuscript for important intellectual content. YZ was involved in the acquisition of data and provided technical support with the genotyping. EWT helped conceive the study, and was involved in the acquisition of data. KB conceived the study, participated in its design and coordination, and helped secure funding. TRH was involved in the critical revision of manuscript for important intellectual content and provided statistical expertise. MMB was involved in the study concept and design, study supervision, critical revisions of the manuscript for intellectual content, and helped obtain funding. BPL was involved in the study concept and design, study supervision, and obtained funding. All authors read and approved the final manuscript.
Written consent was obtained from the mothers to participate in this study. This study was made possible by the following hospitals from which our study participants were selected: Yale-New Haven, Danbury, Bridgeport, Hartford (CT), and Bay State (MA). We thank the original 1,002 original families who participated in this study. This study was supported by grants ES07456 and ES05410 from the National Institute of Environmental Health Sciences.
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As a researcher, Jonathan is interested in how theoretical and methodological approaches from the social sciences, history and philosophy can be combined to understand and engage with concepts that shape the contemporary world.
He is currently a doctoral candidate in philosophy and the history of ideas at Royal Holloway, University of London (studying under Professor Andrew Bowie). Additionally he is Research Associate at the Amsterdam Centre for Political Thought and the Digital Methods Initiative, University of Amsterdam and Research Fellow at the Tow Center for Digital Journalism, Columbia University.
His thesis is titled "Reason, Language and Experience in German Philosophy from 1759 to 1960″ – and particularly focuses on the works of Immanuel Kant, Johann Georg Hamann, Johann Gottfried Herder, Friedrich Schlegel, Friedrich von Hardenberg (Novalis), Friedrich Nietzsche, Walter Benjamin, Ludwig Wittgenstein, Martin Heidegger, and Hans-Georg Gadamer.
He has a chapter titled "Hamann, Nietzsche, and Wittgenstein on the Language of Philosophers" in Hamann and the Tradition (Northwestern University Press, 2012). For other publications see this page.
In addition to his doctoral research, he is undertaking research projects on the politics of transparency and on how journalists can utilise approaches from the social sciences to enhance coverage of complex issues.
Previously he studied Philosophy at Corpus Christi College, University of Cambridge and Social Sciences at the Open University.
You can see more about his academic work on Academia.edu, Google Scholar and SSRN.


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There is a syndrome called waardenburg's that sometimes has heterochromia (different colored eyes), but it usually also has a patch of white hair in the front of the head. I only mention it because although the general effects are mild in most cases, it sometimes also has a hearing loss associated with it....did the baby pass the newborn hearing screen?
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Cayetanos share special day with 'lola'
TIWI, Albay—Sen. Alan Peter Cayetano and his wife, Lani, mayor of Taguig City, found a special way of celebrating their ninth wedding anniversary on Friday.
They spent it with their "Lola Talet" and more than 50 other members of Lani's clan in this geothermal-gas-rich town in Albay province.
Taking some time out from the campaign through Bicol, they made a surprise visit to Lola Talet, or Estelita Campo Clariño, 86, Lani's grandmother.
Lola Talet, who shuns dentures because they irritate her gums, loves to eat vegetables, rice porridge (lugaw) and "sometimes pancit," and plays bingo, a daily pastime at a neighbor's house, from 1 p.m. to 5 p.m., according to clan members.
Lola Talet is mother to a brood of nine, among them Ceferina Clariño Lopez, Lani's mother, who traces her family roots to this town.
Lani, or Maria Laarni, attended Grades 2 and 3 at Barangay Cale Elementary School in this town.
Lola Talet said Lani was a "bright and obedient pupil" during her elementary school days, remembering that Lani walked to school.
She said Lani and her sister stayed with her for two years, from 1989 to 1991, at their ancestral home in Barangay Cale, 3 kilometers from the town center.
After 1991, Lani's mother decided to take Lani to Bulacan to continue her studies there.
"My mother, who runs a small eatery, a carinderia in Marilao town, was the family's sole breadwinner," Lani said.
She said she was in Grade 6 when she was orphaned after her father died in 1994.
Lani finished mass communication at Centro Escolar University in 1991. In 2001, Lani joined the staff of then Sen. Renato Cayetano as executive assistant.
Alan was on his father's staff and that's where he met Lani. They fell in love and married on March 22, 2004.
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Jay-Z And Kanye West Will Be At Madison Square Garden Next Month
Jay-Z and Kanye West will follow up their Izod Center performances as The Throne with two shows at Madison Square Garden, November 7 and 8. Tickets go on sale to those people who have an in with Citibank on Wednesday at 10 a.m., and the rest of the world can get tickets on Friday at 10 a.m. (Guess Kanye's Occupy Wall Street appearance didn't put a dent in cross-promotional opportunities with the big banks.) Every ticket still comes with a digital copy of Watch The Throne, by the way, for those of you who didn't pick it up all those weeks ago.
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