text: Quick View save 68% Heads In Beds: A Reckless Memoir Of Hotels… by Jacob Tomsky November 5, 2014 | Hardcover Out of stock online from $9.50 In the tradition of Kitchen Confidential and Waiter Rant , a rollicking, eye-opening, fantastically indiscreet memoir of a life spent (and misspent) in the hotel industry. Jacob Tomsky never intended to go into the hotel business. As a new college graduate, armed only with a philosophy degree and… See Details $10.00 / $9.50 lowest price*was $29.95

subset: commoncrawl


text: For the main page, see [[LightNovel/ChuunibyouDemoKoiGaShitai here]].----* {{Anvilicious}}: "Everyone has their own way of dealing with sadness." "We all need to escape our reality sometimes".** SomeAnvilsNeedToBeDropped: Once again, depends on the viewer.* AlternativeCharacterInterpretation: ** [[spoiler:Shinka]] is arguably more obsessed than the rest of the cast when it comes to creating a separate identity for herself. Over the course of the anime series, she signs up as the class representative, joins several different clubs, dyes her hair, and attempts to become president of the student council. All of this is done in order to establish herself as something other than a chuuni.* AwesomeMusic: In true KyotoAnimation tradition. The ending theme, [[http://www.youtube.com/watch?v=uRj4_i-eUPU "Inside Identity"]], is particularly awesome.* BaseBreaker: The licenses taken by Kyoto Animation at adapting the light novel to anime have received some flak. Many people see the insertion of multiple {{CanonForeigner}}s as an attempt to replicate Kyoani's older success ''LightNovel/HaruhiSuzumiya'' by forcing which esentially is a new SOS Brigade.* BrokenBase: Fan opinion on episode 7 is split. [[spoiler: Some feel that the drama is unnecessary, and that Rikka doesn't need a psychological reason to behave the way she does. Others like the depth and development that it brings her character, as well as the show itself.]]** In episode 11, Yuuta became one, [[spoiler: thanks to a combination of forcing Rikka to give up her chuunibyou ways (to the point of trying to forcably rip the eyepatch off of her) and seeming completely oblivious to how miserable she is when she does give it up.]]*** [[spoiler:Except he's not oblivious to it at all. He knows how much pain Rikka's going through and is even angsting about how guilty he feels about his actions. He just isn't willing to let himself reassure her because he feels it would be irresponsible and go back on his previous actions.]]** The finale of the second season has already become this. A large chunk of the audience hates that they [[spoiler: spend the whole season building up to a BigDamnKiss only to have it NOT happen at the very end. Typical for ''Creator/KyotoAnimation'', but reeks of a cop-out.]]* EarWorm: ''Lite'''s ending.* EnsembleDarkhorse:** Kuzuha became popular enough to get an ever-so-slightly more important role in ''Ren''.** Touka is popular with those who would prefer more of a {{Deconstruction}} of the story or who simply like a strong antagonist, which she certainly is if the "defeats" of the heroes are anything to go by.* HilariousInHindsight: Some fans have noted that the real [[Creator/JunFukuyama Dark Flame Master]] will come to life when he becomes TheHero in ''LightNovel/MaoyuuMaouYuusha'' [[spoiler: especially after wearing the BlackKnight armor.]]** Let's not forget [[Manga/SaintSeiyaTheLostCanvas Bennu Kagaho]], looks this is on Creator/JunFukuyama's blood, after all.* LesYay: Shinka and Dekomori.** FoeYay** So much so that they end up [[spoiler:accidently kissing in the bonus OVA.]]** Dekomori's response to Rikka saying she's in love with Yuuta in episode 10 can be seen as this, completely with MurderTheHypotenuse (she snapped out of it fast and helped to give her "master" confidence to confess to Yuuta).*** And her reaction to being hugged by Rikka.* MemeticMutation: [[https://www.youtube.com/watch?v=K9O1TMJyhmw Woop Woop]][[labelnote:Explanation]]Rikka's finger spinning & butt shaking in the OP.[[/labelnote]]** There have been more than a fair share of full-on parodies of the entire opening and also the introductory section of episode 1. For example [[https://www.youtube.com/watch?v=AHfyWdcoO_E this]] ''Literature/{{Another}}'' version.** When I'm- [[http://www.youtube.com/watch?v=Ci8t-3p3vK0&feature=related Dark Flame Master?]] (Hidden finger spinning included!)* {{Moe}}: Rikka, hands down.** Kumin as well.** Don't forget about Sanae.** I think it's safe to say that pretty much every character in this series is moe to some degree.* RootingForTheEmpire: Quite a lot of people who watched the anime became [[StealthPun desillusioned]] about the main pair and expected something more deconstructive going on, like parts of the LightNovel. Consequently they took sides with Yuuta pre-12th episode and Touka rather than how the show eventually turned out. Others simply side with Touka on principle of being able to "defeat" the heroes regularly with but a ladle.* TearJerker: The end of episode 7 and the beginning of episode 8. ** After Rikka is hit with the fact that [[spoiler:her father is dead]], we can't see how she is going to react because the half of her face we are shown is obscured by her eyepatch. [[spoiler: Then a tear rolls down.]]** Rikka [[spoiler:finally accepting her father's death.]]--> '''Rikka''': [[spoiler:Goodbye, father.]]* WhatDoYouMeanItsNotForKids: Despite being very lighthearted and not very violent, both of the anime adaptations are rated "TV-MA" when streamed on Hulu. This is highly unusual, because on IMDB it is rated "TV-G". While it may not be the best show for young children to watch, it certainly doesn't warrant a "mature" label. "TV-14", is probably the ideal rating.


text:
Compass Talk + Dinner & Drinks
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We're looking for speakers on this topic. Let us know if you have any reommendations! Learn more
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Recent Meetups
February 26 · 6:30 PMJavaScript Creators: Vue.js with Evan YouWe are co-hosting with the NYC JavaScript Meetup. RSVP on their page here. The speaker: Evan You is the creator of Vue.js and an alumni of Google Creative Lab. Evan is... Learn more
September 29, 2014 · 6:30 PMRick Waldron's Nodebot Demo + DinnerPLEASE NOTE - This event is also listed under the NYC JavaScript meetup page. You only need to RSVP under this group or that one. Please don't RSVP twice! Suggested... Learn more
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text:
BioMarin Pharmaceutical
|Public company
|Traded as
|San Rafael, CA, USA
Key people
|Jean-Jacques Bienaime, Chief Executive Officer
Henry J. Fuchs, Chief Medical Officer
Dan Spiegelman, Chief Financial Officer
|Kuvan, Naglazyme, Aldurazyme, Firdapse, Vimizim
|US$ 751 million (2014)[1]
|US$ -133 million (2014)[1]
|Total assets
|US$ 2.49 billion (2014)[1]
|Total equity
|US$ 1.52 billion (2014)[1]
Number of employees
|1681 (2015)[2]
|Footnotes / references
BioMarin Pharmaceutical Inc. is a biotechnology company based in San Rafael, California. It has offices and facilities in the United States, South America, Asia, and Europe. BioMarin develops and commercializes innovative biopharmaceuticals for serious, life-threatening rare diseases and medical conditions. BioMarin's core business and research is in enzyme replacement therapies (ERTs). BioMarin is the first company to provide therapeutics for mucopolysaccharidosis type I (MPS I), by manufacturing laronidase (Aldurazyme, commercialized by Genzyme Corporation). BioMarin is also the first company to provide therapeutics for phenylketonuria (PKU).
BioMarin was founded in 1997 by Christopher Starr Ph.D. and Grant W. Denison Jr. with an investment of a $1.5 million from Glyko Biomedical and went public in 1999.[5][6]
Business development[edit]
In 2002, BioMarin acquired Glyko Biomedical.[7]
In 2009, BioMarin acquired Huxley Pharmaceuticals, Inc. (Huxley), which had rights to a proprietary form of 3,4-diaminopyridine (3,4-DAP), amifampridine phosphate.[8] In 2010, BioMarin was granted marketing approval by the European Commission for 3,4-diaminopyridine (3,4-DAP), amifampridine phosphate for the treatment of the rare autoimmune disease Lambert-Eaton myasthenic syndrome (LEMS). BioMarin launched the product under the name Firdapse.[9]
In 2010, BioMarin acquired LEAD Therapeutics, Inc. (LEAD), a small private drug discovery and early stage development company with key compound LT-673, an orally available poly (ADP-ribose) polymerase (PARP) inhibitor studied for the treatment of patients with rare, genetically defined cancers.[10] This acquisition was followed by the purchase of ZyStor Therapeutics, Inc. (ZyStor), a privately held biotechnology company developing ERTs for the treatment of lysosomal storage disorders and its lead product candidate, ZC-701, a fusion of insulin-like growth factor 2 and alpha glucosidase (IGF2-GAA) in development for Pompe disease.[11] At its R&D day in October 2010, BioMarin also announced a new program for a peptide therapeutic for the treatment of achondroplasia (BMN-111).[12]
In 2012, BioMarin acquired Zacharon Pharmaceuticals, a private biotechnology company based in San Diego focused on developing small molecules targeting pathways of glycan metabolism.[13]
In 2014, BioMarin acquired a histone deacetylase inhibitor chemical library from Repligen for $2 million with the intention of advancing work toward therapies for Friedreich's ataxia and other neurological disorders.[14] In November, the company announced its intention to acquire Prosensa for up to $840 million.[15]
As of 2014, BioMarin has five products on the market, each of which is an orphan drug.[16]
- Tetrahydrobiopterin (branded as Kuvan) (sapropterin dihydrochloride), a small molecule drug for phenylketonuria, introduced in 2007 as the first medication-based intervention to treat phenylketonuria[17]
- Arylsulfatase B (branded as Naglazyme) (galsulfase), a recombinant protein therapeutic for Maroteaux–Lamy syndrome (also called mucopolysaccharidosis type VI)
- Iduronidase (branded as Aldurazyme), a recombinant protein therapeutic for mucopolysaccharidosis I
- Amifampridine (branded as Firdapse), a small molecule drug for Lambert–Eaton myasthenic syndrome (as of 2013 approved in the EU only)
- Elosulfase alfa (branded as Vimizim), is the only enzyme replacement therapy to address the cause of Morquio A Syndrome (MPS IVA), which affects an estimated 3,000 patients in the developed world. The disease occurs as a result of a deficiency of activity in an enzyme involved in glycosaminoglycan (GAG) metabolism.
In 2010, BioMarin became involved in controversy[18][19] surrounding 3,4-diaminopyridine (3,4-DAP). BioMarin markets a phosphate salt of 3,4-DAP under the name Firdapse. In 2010, BioMarin was granted exclusive licensing rights to Firdapse for 10 years. As a result, the price of a prescribed National Health Service treatment course has increased from $1,987 for the unlicensed drug to $69,970 for Firdapse. The company states that prior to its licensing, there was no guaranteed quality control of the product and no way of formally monitoring for uncommon side effects through the regulatory process.[20]
In 2013, BioMarin Pharmaceuticals was at the center of a high profile debate regarding expanded access of cancer patients to experimental drugs.[21] On the advice of her doctor, Andrea Sloan, a patient with advanced ovarian cancer, requested that the company provide her with access to BMN 673, an unapproved PARP inhibitor drug candidate that had exhibited promising activity in a small Phase 1 clinical trial. The company declined, citing safety concerns.[22] Ms. Sloan eventually received a similar drug candidate from a different company.[23]
In 2015, there was another controversy over expanded access, concerning the supply of a drug on clinical trial to a German child who was suffering from a brain disorder but who was not part of the trial.[24]
Use YYYY-MM-DD format for publication dates
- ^ a b c d "BioMarin Pharmaceutical 2014 Annual Report Form (10-K)" (XBRL). United States Securities and Exchange Commission. March 2, 2015.
- ^ BioMarin Pharmaceutical (2015-03-02). "2014 Form 10-K Annual Report". SEC. Retrieved 2015-03-05.
- ^ BioMarin Pharmaceutical (BMRN) annual SEC income statement filing via Wikinvest.
- ^ BioMarin Pharmaceutical (BMRN) annual SEC balance sheet filing via Wikinvest.
- ^ "BioMarin". Capturing the History of Biotech. Life Sciences Foundation. Archived from the original on 2013-12-28. Retrieved 2014-02-18.
- ^ "History". (corporate website). BioMarin. Archived from the original on 2013-12-28. Retrieved 2014-02-18.
- ^ "BioMarin Pharmaceutical Acquires Glyko Biomedical". Deals. LEXPERT (Thomson Reuters). January 2003. Archived from the original on 2013-12-28.
- ^ Stevens, Loralee (2009-10-27). "BioMarin Acquires Huxley Pharmaceuticals". North Bay Business Journal (Santa Rosa, California, United States). Archived from the original on 2011-01-04. Retrieved 2014-02-18.
- ^ "BioMarin launches LEMS drug Firdapse in European Union; and Genmab gets conditional approval for Arzerra". The Pharma Letter. 2010-04-20. Retrieved 2014-02-18.(subscription required)
- ^ Brown, Steven E.F. (2010-02-04). "BioMarin to buy Lead Therapeutics for $18M". San Francisco Business Times. Archived from the original on 2011-06-29. Retrieved 2014-02-18.
- ^ Leuty, Ron (2010-08-17). "BioMarin to buy ZyStor for up to $115M". San Francisco Business Times. Archived from the original on 2011-06-29. Retrieved 2014-02-18.
- ^ Andersen, Karen (2010-10-21). "BioMarin Highlights Diverse Early-Stage Pipeline at R&D Day". Morningstar. Retrieved 2011-02-14.
- ^ Brown, Steven (2013-01-07). "BioMarin Pharmaceutical buys Zacharon for $10 million". San Francisco Business Times. Retrieved 2013-01-07.
- ^ "BioMarin Nabs Repligen's HDACi Compound Library". News: Discovery & Development. Gen. Eng. Biotechnol. News (paper) 34 (4). 15 February 2014. p. 14.
- ^ http://www.genengnews.com/gen-news-highlights/biomarin-to-acquire-prosensa-for-up-to-840m/81250633/
- ^ BioMarin Office Site: Products
- ^ Pollack, A (2007-12-14). "Agency Approves Drug to Treat Genetic Disorder That Can Lead to Retardation". The New York Times. Retrieved 2008-04-03.
- ^ Goldberg, Adrian (2010-11-21). "Drug firms accused of exploiting loophole for profit". BBC News. Retrieved 2010-11-21.
- ^ Martin, Daniel (2010-09-27). "Hospitals are forced to use unlicensed medicines to save millions". Daily Mail (London). Retrieved 2010-11-21.
- ^ "What makes an orphan drug?". British Medical Journal. 2010-11-10. Retrieved 2010-11-21.
- ^ "Andrea Sloan Faces Pharma Firm With History Of Indifference". Huffington Post. 2013-09-26. Retrieved 2013-12-24.
- ^ "In cancer drug battle, both sides appeal to ethics". CNN. 2013-09-20. Retrieved 2013-12-24.
- ^ Ed Silverman for Pharmalot. October 4, 2013 Andrea Sloan, 'Poster Child' For Compassionate Use, Gets A Drug
- ^ "Hannahs Kampf gegen Pharmafirma". B5 aktuell. 2015-05-13. Retrieved 2015-05-13.


text:
UPDATE: Not sure if this is true, but enjoy the entertainment. You know how gossip goes.
According to creambmp.com "The whole world wondering where Andre 3k been …just check Big Boi's phone. He's right there, naked." said Sherlita M. Patton at a deposition early Wednesday morning after allegedly finding explicit photos of the "Hey Ya" singer in her husbands phone.
Sherlita decided to file for divorce from rapper Big Boi real name Antwon Patton after 11 years of marriage on October 3rd citing that it was "irretrievably broken" according to Huffington Post. The deposition held this morning was to finalize there decision to legally separate where Sherlita's sister came along for moral support.
"So you mean to tell me he's gay AND has a tiny–weird penis. I'ma need him to pick a struggle" – Sherlita's Sister
Sherlita who is a big hip hop fan herself also feels for the fans who want more music saying "you might see an Outkast p0rn0 before you'll see another album".
Pingback: Hip-Hop Rumors: Another Bad Rumor, Andre 3000 and Big Boi | News as they Happen()
Pingback: Divorce Court: Big Boi's wife claims he has naked pics of Andre 3000 in his cell phone: |()
Pingback: Outkast to Reunite at Coachella 2014? | Tha Produce Section()


text:
As of Wednesday, October 10, 2012
© Copyright 2015 Gwinnett Daily Post
E.T. The Extra-Terrestrial 30th Anniversary Edition Blu-ray (PG)
Movie: 4 out of 4 stars
Disc: 4 out of 4 stars
Landing just a small notch below "the Wizard of Oz" as the most beloved fantasy film of all-time, the most lasting effect of "E.T." was not just to make sci-fi welcome for mass audiences but more to paint an alien as the premiere protagonist amidst an array of shortsighted and thuggish adult humans. This timeless masterpiece hasn't lost a lick of appeal with the new Blu-ray transfer is immaculately clear and crisp and the bevy of bonus featurettes provides a veritable treasure trove for fans new and old.
Technical specs: aspect ratio: Widescreen (1.85:1/1080p), audio: English (DTS-HD-MA 7.1), French and Spanish (DTS Digital Surround 5.1), subtitles: English, French and Spanish.
Special features include:
8 featurettes
Pocket BLU app
Ultraviolet option
Additional DVD disc
BD Live
(Universal, $34.98)
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- DISC SPOTLIGHT: 'To Kill a Mockingbird' ( February 2, 2012 )
- DISC SPOTLIGHT: 'The Princess Bride' 25th Anniversary Edition ( October 4, 2012 )
- DISC SPOTLIGHT: Sideways 10th Anniversary Edition Blu-ray ( October 9, 2014 )


text:
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Tab Sleeve Crop Denim Jacket
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Thompson views Oxford damage; receives commission to Canada
Historian Jack Mayfield writes this week about Jacob Thompson and his return to Oxford to see the damage it suffered by the North's occupation. (April 4, 2014, Page 2B)
Mississippi 11th's winter rest south of the Rapidan about to end
Historian Jack Lamar Mayfield brings us back to the Civil War this week and the events leading up to Grant's appointment as general. (March 14, 2014, Page 3B)
Confederate soldier died from unknown illness
A Confederate soldier, Frank H. Jones, is one of 11 people buried at old cemetery off CR 251 where builders have to petition the Chancery Court to move the graves. (March 3, 2014, Page 12)
The slave community in Lafayette County
Historical columnist Jack Mayfield ends his month-long Black History Month series by focusing on the living conditions of slaves in Lafayette County. (February 28, 2014, Page 4B)
Grant's 1862 order still felt today?
Jewish businessman Asher Reese would like to see a Jewish Community Life Center built on the same land where Gen. Grant issued his No. 11 order that ordered the expulsion of all Jews in Tennessee, Mississippi and Kentucky. (February 25, 2014, Page 1)
An accumulating investment — Good masters don't seperate families
Historian columnist Jack Mayfield continues his series on Lafayette County's slavery past for Black History Month. (February 21, 2014, Page 3B)
The second Middle Passage of the American slave
History columnist Jack Lamar Mayfield continues his series on the history of African-Americans in Lafayette County with the story of Thomas Taylor, who was born into slavery in 1853. He was the grandfather of Oxford Alderman Preston Taylor. (February 14, 2014, Page 2B)
Celebrate Black History Month with a visit to the Burns-Belfry
Black History month is a great time to visit the newly opened Burns-Belfry Museum. Historical columnist Jack Mayfield writes this week about George Washington Fox, one of Lafayette County's first black landowners. (February 7, 2014, Page 2B)
William Faulkner and the Civil War in his novels, Part 2
Historical columnist Jack Mayfield continues this week with discussing William Faulkner's use of the Civil War and the influence it had on his writing. (January 24, 2014, Page 2B)
Faulkner, Shelby Foote visit Shiloh
Historian Jack Lamar Mayfield writes this week about William Faulkner and his fascination with the Civil War. (January 17, 2014, Page 3B)


text:
27 January 2012 03:22 [Source: ICIS news]
SINGAPORE (ICIS)--?xml:namespace>
The cargo was awarded to Shell at a premium of $27/tonne (€21/tonne) to
($1 = €0.76)
For more on naphtha, visit ICIS chemical intelligence
For the latest chemical news, data and analysis that directly impacts your business sign up for a free trial to ICIS news - the breaking online news service for the global chemical industry.
Get the facts and analysis behind the headlines from our market leading weekly magazine: sign up to a free trial to ICIS Chemical Business.
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Asian Chemical Connections


text:
Roaches In The Attic
Raymond Towers
Smashwords Edition
Copyright 2010 Raymond Towers
About the cover: The image displayed is titled Soldier With Gun. This picture was taken by Aaron Amat and can be found at Fotofolia.
Smashwords Edition, License Notes: Thank you for viewing or downloading this free sample. You are welcome to share this ebook with your friends provided that it remains in its complete original form and is not used for any commercial purpose. If you enjoy reading this story, please consider posting a review or making a purchase of one of the author's other titles at Smashwords. Thank you for respecting the hard work of this author.
Publisher's Note: This book is a work of fiction. Names, characters, places and incidents are the products of the author's imagination. Any resemblance to actual persons, living or dead, is entirely coincidental.
Some of the reviews for this ebook:
Aliens and alien planets at their best! I could not put this one down. (C. Blake, Smashwords)


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Paquet : wmii2-doc (1-9) [universe]
Liens pour wmii2-doc
Ressources Ubuntu :
Télécharger le paquet source wmii2-doc :
Responsable :
Please consider filing a bug or asking a question via Launchpad before contacting the maintainer directly.
Original Maintainers (usually from Debian):
- Debian Suckless Maintainers
- Daniel Baumann
It should generally not be necessary for users to contact the original maintainer.
Ressources externes :
- Page d'accueil [www.suckless.org]
Paquets similaires :
lightweight tabbed and tiled X11 window manager, version 2 (documentation)
wmii is a dynamic window manager for X11, which is highly customizable and usable with keyboard and mouse. It supports conventional, tabbed and tiled window management with low memory usage. It is highly modularized and uses an inter-process communication interface which is oriented on the 9p protocol of plan9.
This package contains the collected documentation of wmii 2.
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Télécharger wmii2-doc
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text:
The European Union has left a sour taste among mango exporters with its decision to temporarily ban the import of Alphonsos from India from May 1 due to the alleged presence of pests in them. The trading community pegs the loss because of the ban at more than Rs100 crore as India is the leading exporter of mangoes in the world. India accounts for more than half of the total mango production in the world.
Industry experts said the development will adversely affect thousands of Mumbai-based businessmen who regularly send mangoes as gifts to their clients and lovers of the fruit in Europe. "There are thousands of businessmen, especially from the diamond trader community, who send gift boxes containing mangoes during this season to their clients. The ban will not just affect them but also other mango lovers from Europe who will be deprived of the king of fruits," said APMC director Sanjay Pansare, who is also an expert in vegetable and fruit trade.
A doting father who had planned to take a box of mangoes for his daughter in Europe is saddened with the ban. "It is upsetting as my daughter loves mangoes. I was looking forward to taking a box of mangoes when I travel there in May," said the senior professional employed with a private firm in Mumbai.
The 28-member European Union announced the ban on the import of mangoes from India after a certain consignment imported last year was found to be infested with pests. The ban has also been imposed on snake gourd, bitter gourd, taro plant, and egg plant. A revision of the ban will take place before December 31, 2015.
Maharashtra, which produces large quantities of Alphonso, Badami, Kesar, Neelam and Payari varieties of mangoes in Sindhudurg, Raigad and Ratnagiri region, is among the leading exporter of mangoes to foreign countries, including the US, Gulf and parts of Europe. Most of these fruits are exported from Chhatrapati Shivaji International Airport in Mumbai. Airport sources said airlines stop taking other export commodities to accommodate the rush of mango consignments, which forms about 80 per cent of perishable export during the peak months of May and June. An Air India spokesperson, however, told dna: "The ban by EU will not affect the earnings of the airlines as export of mangoes will be substituted by other commodities."
The UK imports nearly 16 million mangoes from India and the market for the fruit is worth nearly 6 million pounds a year.


text:
5 Brain BoostersStress and age can lead to memory loss. Supplements and lifestyle changes give you a head start to a healthy mind.
Coenzyme Q10
"Very important" is how Khalsa describes this energizing antioxidant. "It works on different areas of the brain and increases mental energy," he says. "It makes you more alert." According to Gonzalez, current studies are looking at whether high doses (up to 1,200 mg daily) can help patients with early-stage Parkinson's disease, a degenerative condition in which impaired delivery of dopamine in the brain affects movement. Khalsa cites an earlier study that found some benefit at doses of 1,200 mg daily, especially when combined with at least 100 mg of alphalipoic acid, a cell nutrient.
How to Use It: For better energy and prevention of cognitive decline, Khalsa suggests taking 100 to 300 mg per day; you should triple that dosage if memory loss has already occurred. Patients taking statins should supplement, he adds, since the drugs deplete the body's store of coenzyme Q10.
Sage Oil
Oil from Spanish sage (Salvia lavandulifolia) has been shown to decrease the activity of the acetylcholine-destroying enzyme. An Iranian investigation found that patients with mild to moderate Alzheimer's showed significant improvement in cognitive symptoms when given 60 drops of common sage extract (Salvia officinalis) daily. Sage also contains a number of antioxidants.
How to Use It: James J. Gormley, co-author of User's Guide to Brain-Boosting Supplements, recommends 2.5 to 7.5 grams per day of sage tincture, or 1.5 to 3 grams of liquid extract. "Keep in mind that 1 teaspoon of sage in food is about 1.5 grams," he notes.


text:
The Greco-Persian WarsPaperback
List price $33.83
You save $5.96 17% off
Free delivery worldwide
Dispatched in 1 business day
When will my order arrive?
- Publisher: University of California Press
- Format: Paperback | 356 pages
- Dimensions: 152mm x 234mm x 24mm | 540g
- Publication date: 15 October 1998
- Publication City/Country: Berkerley
- Edition statement: First Edition, with a New Fore ed.
- Illustrations note: 16 b&w illustrations, 12 maps
- Sales rank: 186,184
Product description
This is a reissue, with a new introduction and an update to the bibliography, of the original edition, published in 1970 as The Year of Salamis in England and as Xerxes at Salamis in the U.S. The long and bitter struggle between the great Persian Empire and the fledgling Greek states reached its high point with the extraordinary Greek victory at Salamis in 480 B.C. The astonishing sea battle banished forever the specter of Persian invasion and occupation. Peter Green brilliantly retells this historic moment, evoking the whole dramatic sweep of events that the Persian offensive set in motion. The massive Greek victory, despite the Greeks' inferior numbers, opened the way for the historic evolution of the Greek states in a climate of creativity, independence, and democracy, one that provided a model and an inspiration for centuries to come. Green's accounts of both Persian and Greek strategies are clear and persuasive; equally convincing are his everyday details regarding the lives of soldiers, statesmen, and ordinary citizens. He has first-hand knowledge of the land and sea he describes, as well as full command of original sources and modern scholarship. With a new foreword, The Greco-Persian Wars is a book that lovers of fine historical writing will greet with pleasure.
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Author information
Historian, critic, essayist, translator, and novelist, Peter Green is Dougherty Centennial Professor Emeritus in Classics at the University of Texas and Visiting Professor of History at the University of Iowa. His other books available from California include Alexander to Actium: The Historical Evolution of the Hellenistic Age (1990), Alexander of Macedon, 356-323 B.C.: A Historical Biography (1991), The Laughter of Aphrodite: A Novel about Sappho of Lesbos (1993), Hellenistic History and Culture (1995, editor), Classical Bearings: Interpreting Ancient History and Culture(1998), and a translation of Apollonius Rhodius's The Argonautica.
Review quote
"Good acquaintance with the terrain and an acute understanding of ancient tactics have enabled Green to make a number of clever suggestions as to how certain battle scenes in Herodotus ought to be interpreted, and in this respect he has made a contribution to the literature about the War."--Frank J. Frost, "Classical Philology
Back cover copy
"Peter Green's "The Year of Salamis is deservedly famous, combining scholarship and imagination with the ability to tell a stirring tale."--J. F. Lazenby, author of "The Defence of Greece, 490-479 B.C.


text:
Armstrong MetalFest is the emerging heavy metal festival to attend, located in the heart of British Columbia, Canada. Featuring more than 30 local and international musicians together at the Hassen Arena in the small town of Armstrong.
Prepare for the 7th annual heavy metal and camping music festival. Camping is included with the purchase of a ticket and there will be several other events throughout the weekend for your enjoyment.
Presale tickets are available online, click here. Just bring your receipt of the ticket purchase and you will receive entrance and your ticket on the day of the festival!


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A pair of underachieving cops are sent back to a local high school to blend in and bring down a synthetic drug ring.
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The lec-dem on Yakshagana, an interesting introduction to the tala system and the close links between Manipuri and the Thang Ta martial arts were dealt with in detail at the Natya Kala Conference.
How confusing the 'classical' and 'folk' categorising is in reference to the Indian situation, was reinforced in the 'Abhyaasa Sampradaya' lecture/demonstration on Yakshagana by Keremene Shivananda Hegde of Shri Idagunji Mahaganapati Yakshagana Mandali during Krishna Gana Sabha's 31 Natya Kala Conference.
Belonging to the Badagu Tittu, stretching from Udipi to Shirur (Shivmogga, Chikkamagalore and Malenadu areas), Karnataka's regional theatre form of Yakshagana Bayalata, which includes the Tenku Tittu and Badabagadu Tittu North Kanara style, is a people's art traced back to the 15-16 centuries - its total theatre presenting themes from the Puranas and epics, combining dialogue (vachikabhinaya) with dance and music following stylised prescriptions of grammar and raga, alongside improvised elements suitable to a particular character emerging from the actor's on-the-spot creativity. High literary skills are required to tailor dialogue trends to not just highlight the character but also make the situation in the story contemporarily relevant.
Subtle humour
For those who witnessed the Karthaviryarjuna performance the evening before, Ravana's boastful claims and promises about benefits to the subjects during his rule, sounded every bit like the politician to-day orating about the greatness of his rule vis-a-vis the abject misrule of previous governments. The subtle humour in exchanges between characters emerges from adroit repartee, outside the written script of the play.
Shivananda's interesting introduction to the tala system, in the demonstration showed how talas are associated with melodic modes (ragas) - the seven matra Kore tala in Khambodi, Eka tala associated with Madhyamavati, Jhampe in Mohanam and Triputa in Khambodi. Himmela includes the high-pitched singing of the Bhagavataru a must while performing in open fields with very large audiences and no microphones and Maddala and Chenda percussions. The straight Carnatic singing has less curves and gamakas. Known for its interpretative sensitivity, the winsome abhinaya to the lyric 'Rangaiyya Odi Baro' was by the female character (donned by male).
The enactment, the previous evening of Karthaviryarjuna, treading the forest with the palace damsels to river Narmada for 'Jalakrida,' was so evocative that on the empty stage one felt the wetness of water during the merry-making. Shivananda's own presentation of moving abhinaya, portrayed Rama analysing his own life with its plate full of sorrows and some joys, 'Novugalinda Tudida Jeevanave Kandaaitu.' The grandeur of the aesthetic costumes with the elaborate headgear (Munda-s), and the jewellery made of wood, with make-up special for each character, owes much of its sophistication to the contributions of Hegde's father, the genius Sri Keremene Shambhu Hegde, who injected new life into Yakshagana.
The female characters, aesthetically turned out are so convincing, their steps redolent with lasya grace unlike the Male Oddilaga (entrance) full of vigour and movement variety with rhythmic patterns. Deft gait changes suffice to convey whether characters are crossing large tracts of land, or rocky terrain or even water. Yakshagana is the art of imagination and the range of characters from malefic to benevolent can hold audiences spellbound with the song/ dance/ dialogue narrative.
Manipuri made easy
Never has one been treated to a more lucid and intelligently planned lecture demonstration that was what presented by Lokendrajit Singh of Jawaharlal Manipuri Academy from Imphal. He first established the close links between Manipuri and the Thang Ta martial art, practised by the 30 odd warrior tribal sects inhabiting the Manipur state. Jumping with feline grace the distance of 2 ½ feet, from one pillar to the next in the two pillared traditional homes was how warriors acquired the agility. The main stance with the feet crossed one in front of the other for Thang Ta and in a swastika at the back for Manipuri constituted the main difference. The martial art movements and the lilting movement patterns of Lai Haraoba where abstract serpentine body movements (of which there are 385 types) evoke a formless tribal deity, melded to make Manipuri. The 'chali-s' taught first, combining measured body and hand geometry forming circles, the curved line and the serpentine movement, look easy in fluid grace but require rigorous training. The exercises preparing the body to move in a graceful S or 8-shaped up and down movements were demonstrated. The tala structure with Tanchep (4+4), Menkup (3+3), Tanchep Aroibi of 16 matras and Misrajati tintalmacha as examples was explained. The body with weight raised off the floor and very light foot contact, has foot raise in the air at articulated tala points – which is why the ankle bells are dispensed with, as being inimical to restrained aesthetics. The pirouettes and circling clockwise and counter clockwise (navadik parikrama) and the tala with Pung and Kartal (cymbal) playing with singing and dancing in Sankirtan, was briefly explained with an abbreviated Pung Cholom demonstrated by Lokendra Singh.
Explaining Vaishnavism's superimposition on the regional religious beliefs, led to the story of how the Jackfruit tree, which bled when axed, was fully uprooted to float in the river. Sinking into the river and pulled up only when Raja Bhagyachandra personally supervised its retrieval, its wood went into the making of the image of Govindjee housed in the temple which became the site for Maha Ras. Manipuri's first coming out of its home with Amubi Singh composing 'Neela Kamaladala Shyam' in 1936, rendered by Amla Shankar to the present Pancha Prana Samarpilo and Ashtapadis of Gita Govind is a big change. Demonstrating the throbbing character of Manipuri music with its own identity, neither Hndustani nor Carnatic, also made for a brilliantly informative morning.
Keywords: Natya Kala Conference, dance forms


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Colts' Anthony Castonzo has sprained knee ligament
Andrew Luck's protectors are now taking their own hits.
Colts coach Chuck Pagano said Sunday that left tackle Anthony Castonzo will not play in the preseason finale after an MRI confirmed Castonzo has a mild sprain of the medial collateral ligament in his right knee. Castonzo was injured on the opening series' of Saturday night's 27-6 victory over Cleveland and did not return. Right guard Mike McGlynn did not play Saturday after bruising his knee during practice last week.
Castonzo is listed as day-to-day, and Pagano said Sunday he hopes both would be ready for the Sept. 8 opener against Oakland.
''The MRI was pretty much negative. It wasn't as bad as anybody anticipated,'' Pagano said, discussing Castonzo's prognosis during a conference call. ''You never want to lose anybody, and particularly the guy who's protecting the blind side of your quarterback.''
Joe Reitz will replace Castonzo in the lineup at Cincinnati. Reitz started nine games in 2011 and eight last season, all with the Colts, after being cut by the Ravens in 2010.
Protecting Luck was Indy's top offseason priority after yielding 41 sacks and dozens more hits last season. General manager Ryan Grigson signed right tackle Gosder Cherilus and left guard Donald Thomas in the first hours of free agency - an effort to shore up Luck's protection. Grigson also drafted two offensive linemen, Hugh Thornton and Khaled Holmes, in the third and fourth rounds, respectively.
While Cherilus and Thomas have been solid, the Colts aren't quite sure what they can expect from their injured rookies.
Holmes sprained his right ankle on the fourth day of training camp and hasn't practiced or played since then.
Thornton sprained his right ankle a few days before training camp opened, returned to practice last week and made his preseason debut Saturday.
''He knocked off a little bit of rust, but he looked pretty good in there in both the run and the pass game,'' Pagano said.
The offensive line isn't the only spot where the Colts are hurting.
Indy's top two tight ends Dwayne Allen (right foot) and Coby Fleener (right knee) sat out against Cleveland, and backup receiver Nathan Palmer left late in the game with a knee injury. Pagano said an MRI confirmed Palmer also has a sprained MCL and is likely to miss four to six weeks - a diagnosis that could jeopardize his ability to make the 53-man active roster.
The Colts have already begun the cut-down process.
On Sunday, they waived 11 players and put backup linebacker Lawrence Sidbury on injured reserve, trimming the 90-man roster to 78. They must be down to 75 by Tuesday.
Sidbury signed on the first day of free agency, a move aimed at helping special teams and bolstering the defense. But he hurt his shoulder in last week's win over the Giants and got a second opinion this past week. Pagano said Sunday he will get another opinion and likely will have surgery.
The Colts also waived cornerbacks Johnny Adams and Allen Chapman, offensive linemen Danous Estenor and Rick Schmeig, defensive tackle Kellen Heard, punter-kicker Brandon McManus, running back Davin Meggett, linebacker C.O. Prime and safety Ashante Williams. Receiver Maurice Williams was waived with an injury settlement. Cornerback Teddy Williams was waived-injured and will revert to Indy's injured reserve if he clears waivers.
AP NFL website: www.pro32.ap.org
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NFL Headlines
NFL Insiders: Dolphins name Dennis Hickey new general manager
Carroll: Seahawks CB Richard Sherman sorry about postgame rant
Browns to interview Bills' Pettine with Broncos' Gase out of running
NFL talking to 49ers about sideline hit vs Seahawks in NFC title game
Falcons hire former Chiefs GM Pioli as assistant general manager


text:
Bomb tears through Damascus, killing 13 people
In Tehran, Iranian Foreign Minister Ali Akbar Salehi said that use of chemical weapons in Syria would also be a "red line" for Iran, but suggested rebel forces should be investigated rather than the Islamic Republic's allies in Damascus.
In the latest alleged attack, activists in the town of Saraqeb in northern Idlib province claimed the government bombed the town late Monday with chemical agents. It said the attack caused respiratory problems and other symptoms among a few residents which they claimed were consistent with a chemical attack.
The Britain-based Syrian Observatory for Human Rights said it was unable to confirm the purported use of chemical agents.
But in response to the claims, border authorities in Turkey decontaminated a group of Syrians wounded in the Saraqeb attack as they entered the country and hospital staff treating them wore protective equipment, according to an aide to the governor of Turkey's Hatay province, which borders Syria.
The aide, who spoke on condition of anonymity citing government rules that bar civil servants from speaking to journalists, told AP on Tuesday there was no indication that chemical weapons were used in Saraqeb attack.
Associated Press journalists Barbara Surk and Bassem Mroue in Beirut, Suzan Fraser in Ankara, Turkey, and Derl McCrudden in Reyhanli, Turkey contributed to this report.
The Associated Press


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|Other names
N-Butylimidocarbonimidic diamide[citation needed]
|ATC code
|EC number
|Jmol-3D images
|Molar mass
|157.22 g·mol−1
|log P
|Related compounds
Related compounds
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|Infobox references
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin.
Chemistry and animal toxicology[edit]
Buformin hydrochloride is a fine, white to slightly yellow, crystalline, odorless powder, with a weakly acidic bitter taste. Its melting point is 174 to 177 °C, it is a strong base, and is freely soluble in water, methanol and ethanol, but insoluble in chloroform and ether.[2][3] Toxicity: guinea pig LD50 subcutaneous 18 mg/kg; mouse LD50 intraperitoneal 140 mg/kg and 300 mg/kg oral.[4] The partition coefficient (log P in octanol-water) is -1.20E+00; its water solubility is 7.46E+05 mg/l at 25 °C. Vapor pressure is 1.64E-04 mm Hg at 25 °C (EST); Henry's law constant is 8.14E-16 atm-m3/mole at 25 °C (EST). Its Atmospheric -OH rate constant is 1.60E-10 cm3/molecule-sec at 25 °C.[5]
Mechanism of action[edit]
Buformin delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose uptake into cells, and inhibits synthesis of glucose by the liver. Buformin and the other biguanides are not hypoglycemic, but rather antihyperglycemic agents. They do not produce hypoglycemia; instead, they reduce basal and postprandial hyperglycemia in diabetics.[6] Biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels.[7]
After oral administration of 50 mg of buformin to volunteers, almost 90% of the applied quantity was recovered in the urine; the rate constant of elimination was found to be 0.38 per hr. Buformin is a strong base (pKa = 11.3) and not absorbed in the stomach. After intravenous injection of about 1 mg/kg buformin-14-C, the initial serum concentration is 0.2-0.4 µg/ml. Serum level and urinary elimination rate are linearly correlated.[8] In man, after oral administration of 50 mg 14-C-buformin, the maximum serum concentration was 0.26-0.41 µg/ml. The buformin was eliminated with an average half-life of 2 h. About 84% of the dose administered was found excreted unchanged in the urine.[9] Buformin is not metabolized in humans. The bioavailability of oral buformin and other biguanides is 40%-60%. Binding to plasma proteins is absent or very low.[10][11][12]
The daily dose of buformin is 150–300 mg by mouth.[13] Buformin has also been available in a sustained release preparation, Silubin Retard, which is still sold in Romania.
Side effects and cotraindications[edit]
The side effects encountered are anorexia, nausea, diarrhea, metallic taste, and weight loss. Its use is contrindicated by diabetic coma, ketoacidosis, severe infection, trauma, other severe infections where buformin is unlikely to control the hyperglycemia, renal or hepatic impairment, heart failure, recent myocardial infarct, dehydration, alcoholism, and conditions likely to predispose to lactic acidosis.
Buformin was withdrawn from the market in many countries due to an elevated risk of causing lactic acidosis (although not the US, where it was never sold). Buformin is still available and prescribed in Romania (timed release Silubin Retard is sold by Zentiva), Hungary,[14][15][16][17] Taiwan[18] and Japan.[19] The lactic acidosis occurred only in patients with a buformin plasma level of greater than 0.60 µg/ml and was rare in patients with normal renal function.[20][21][22] In one report, the toxic oral dose was 329 ± 30 mg/day in 24 patients who developed lactic acidosis on buformin. Another group of 24 patients on 258 ± 25 mg/day did not develop lactic acidosis on buformin.[23]
Anticancer properties[edit]
Buformin, along with phenformin and metformin, inhibits the growth and development of cancer.[24][25][26][27][28] The anticancer property of these drugs is due to their ability to disrupt the Warburg effect and revert the cytosolic glycolysis characteristic of cancer cells to normal oxidation of pyruvate by the mitochondria.[29] Metformin reduces liver glucose production in diabetics and disrupts the Warburg effect in cancer by AMPK activation and inhibition of the mTor pathway.[30]
Buformin was synthesized as an oral antidiabetic in 1957.[31]
Buformin is obtained by reaction of butylamine and 2-cyanoguanidine.
See also[edit]
- ^ F. Macdonald. Dictionary of pharmacological agents: Volumes 1-2 - Page 344, 1997
- ^ Jacker HJ. [New Pharmacologic Products. 2. Buformin For Oral Therapy Of Diabetes]. Pharm Prax. 1964;10:247-9.
- ^ Eustace George Coverly Clarke, Judith Berle, Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences. Isolation and identification of drugs in pharmaceuticals, body fluids and post-mortem material, Volume 1. Pharmaceutical Press 1974, p226
- ^ Shroff JR, Bandurco V, Desai R, Kobrin S, Cervoni P. Chemistry and hypoglycemic activity of benzimidoylpyrazoles. J Med Chem 1981 Dec;24(12):1521-5.
- ^ United States National Library of Medicine ChemLDplus advanced database
- ^ Enrique Ravina, Hugo Kubinyi. The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. Wiley. 2011 p 215
- ^ Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature. 2013 Feb 14;494(7436):256-60. doi: 10.1038/nature11808. Epub 2013 Jan 6. PMID 23292513
- ^ Beckmann R. The fate of biguanides in man. Ann N Y Acad Sci. 1968 Mar 26;148(3):820-32.
- ^ Beckmann R, Lintz W, Schmidt-Böthelt E. Evaluation of a sustained release form of the oral antidiabetic butylbiguanide (Silubin retard). Eur J Clin Pharmacol. 1971 Sep;3(4):221-8.
- ^ Marchetti P, Giannarelli R, di Carlo A, Navalesi R. Pharmacokinetic optimisation of oral hypoglycaemic therapy. Clin Pharmacokinet. 1991 Oct;21(4):308-17 PMID 1760902
- ^ Gutsche H, Blumenbach L, Losert W, Wiemann H. Concentration of 14C-1-butylbiguanide in plasma of diabetic patients and its elimination after administration of a new Galenical formulation. Arzneimittelforschung 1976;26(6):1227-9
- ^ Ritzl F, Feinendegen LE, Lintz W, Tisljar U. Distribution and excretion of 14c-butylbiguanide in man. Arzneimittelforschung 1978;28(7):1184-6
- ^ Gustav Kuschinsky, Heinz Lüllmann. Textbook of pharmacology. Academic Press p 225, 1973
- ^ Hankó B, Tukarcs E, Kumli P, Vincze Z. Antidiabetic drug utilization in Hungary. Pharm World Sci. 2005 Jun;27(3):263-5.
- ^ Hankó BZ, Reszegi CA, Kumli P, Vincze Z. [Practice of antidiabetic therapy in Hungary]. Acta Pharm Hung. 2005;75(2):77-86.
- ^ Jerry L. Schlesser, Gale Research Inc. Drugs available abroad. Derwent Publications, Ltd - 1990 p28
- ^ Verdonck L, Sangster B, van Heijst A, de Groot G, Maes R (1981). "Buformin concentrations in a case of fatal lactic acidosis". Diabetologia 20 (1): 45–6. doi:10.1007/BF01789112. PMID 7202882.
- ^ Chou CH, Cheng CL, Huang CC. A validated HPLC method with ultraviolet detection for the determination of buformin in plasma. Biomed Chromatogr. 2004 May;18(4):254-8.
- ^ Takeda Announces Submission Of Application For Additional Indication Of Actos In Japan; Concomitant Therapy With Biguanides For Type 2 Diabetes. Medical News Today. 28 Jan 2007
- ^ Wittmann P, Haslbeck M, Bachmann W, Mehnert H. [Lactic acidosis in diabetics on biguanides (author's translation)] Deutsche Medizinische Wochenschrift 102(1):5-10, 1977
- ^ Berger W, Mehnert-Aner S, Mülly K, Heierli C, Ritz R. [10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)]. Schweizerische medizinische Wochenschrift. 106:1830-1834, 1976
- ^ Deppermann D, Heidland A, Ritz E, Hörl W (1978). "[Lactic acidosis--a possible complication in buformin-treated diabetics (author's transl)]". Klin Wochenschr 56 (17): 843–53. PMID 713413.
- ^ Luft D, Schmülling RM, Eggstein M. Lactic acidosis in biguanide-treated diabetics: a review of 330 cases. Diabetologia. 1978 Feb;14(2):75-87.
- ^ Sakae Saito, Aki Furuno, Junko Sakurai, Asami Sakamoto, Hae-Ryong Park, Kazuo Shin-ya, Takashi Tsuruo, and Akihiro Tomida. Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation. Cancer Research 2009;69(10):4225–34
- ^ Vladimir N. Anisimov. Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention. Experimental Gerontology Volume 38, Issue 10, October 2003, Pages 1041-1049
- ^ Valery A. Alexandrov, Vladimir N. Anisimov, Natalia M. Belous, Inna A. Vasilyeva and Vera B. Mazon. The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats. Carcinogenesis Volume 1, Issue 12 Pp. 975-978, 1980
- ^ Anisimov VN, Ostroumova MN, Dil'man VM. Inhibition of the blastomogenic effect of 7,12-dimethylbenz(a)anthracene in female rats by buformin, diphenin, a polypeptide pineal extract and L-DOPA. Bulletin of Experimental Biology and Medicine. Volume 89, Number 6, 819-822, 1980
- ^ Vladimir N. Anisimov, Lev M. Berstein, Irina G. Popovich, Mark A. Zabezhinski, Peter A. Egormin, Margarita L. Tyndyk, Ivan V. Anikin, Anna V. Semenchenko, Anatoli I. Yashin. Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens. Annals of the New York Academy of Sciences. 1057:220-234, 2005
- ^ Matthew G. Vander Heiden, Lewis C. Cantley, and Craig B. Thompson. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 324 (5930): 1029-1033, 2009.
- ^ Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 9;310(5754):1642-6.
- ^ Seymour L. Shapiro et al. Salts Of N-Amylbiguanide. US Patent number: 2961377; Filing date: Aug 5, 1957; Issue date: 1960
- ^ Shapiro, S. L.; Parrino, V. A.; Freedman, L. (1959). "Hypoglycemic Agents. III.1—3N1-Alkyl- and Aralkylbiguanides". Journal of the American Chemical Society 81 (14): 3728. doi:10.1021/ja01523a060.


text:
Ztark Communications Auction 86 Las Cruces Grant Public Notice
Download OptionsReleased: January 17, 2014
Federal Communications Commission
News Media Information 202 / 418-0500445 12th St., S.W.
Internet: https://www.fcc.gov
Washington, D.C. 20554
January 17, 2014
Auction 86
Report No. AUC-86 (Auction 86)On October 30, 2009, the Federal Communications Commission completed Auction No. 86 for
Broadband Radio Service licenses in the 2496-2502, 2602-2615, and 2616-2673.5 MHz bands ("BRS").1
After a preliminary review of the FCC long-form applications (FCC Form 601), the application listed in
the Attachment to this Public Notice was accepted for filing.2 Upon further review, we find that the
application listed in the Attachment is complete and conforms to the Commission's rules with respect to
the license listed in the Attachment. Furthermore, the Commission has received full payment, as required
by section 1.2109(a) of its rules,3 for the license listed in the Attachment. With respect to the other
license requested in the application, Ztark has chosen to default on its winning bid for that license,4 and its
application will be dismissed with respect to that license. This partial grant is being made pursuant to a
request from the applicant.5
Accordingly, by this Public Notice, we announce the grant of the license listed in the Attachment.
We grant this license pursuant to Section 309(a) of the Communications Act, 47 U.S.C. § 309(a), and
section 0.331 of the Commission's rules, 47 C.F.R. § 0.331, because it will serve the public interest,
convenience, and necessity.
Please contact Genevieve Ross, Wireless Telecommunications Bureau, Broadband Division, at
(202) 418-1305, for questions regarding legal matters and licensing issues.
1 Auction of Broadband Radio Service Licenses Closes; Winning Bidders Announced for Auction No. 86, Public
Notice, 24 FCC Rcd 13572 (WTB 2009).
2 See Wireless Telecommunications Bureau Announces that Applications for Broadband Radio Service Licenses are
Accepted for Filing, Public Notice, 25 FCC Rcd 1989 (WTB 2010).
3 47 C.F.R. § 1.2109(a).
4 See Letter from John M. Beahn, Esq., counsel for Ztark Communications, LLC to Marlene H. Dortch, Secretary,
Federal Communications Commission (filed Nov. 29, 2013).
5 Id.
Note: We are currently transitioning our documents into web compatible formats for easier reading. We have done our best to supply this content to you in a presentable form, but there may be some formatting issues while we improve the technology. The original version of the document is available as a PDF, Word Document, or as plain text.


text:
Jewelry for You! How to Make Handmade Beaded Bracelets and Necklaces from Consumer Crafts and Crafts Unleashed
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Ruffle Your Feathers Necklace
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Strut your stuff with this fun and sassy Ruffle Your Feathers Necklace! This simple necklace is easy to make and can add a great and colorful flair to any outfit. Jazz up your wardrobe with fun accessories from I Love to Create!
- Tulip® Fashion Glitter™ Shimmer Fabric Paint (Shimmer Green)
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- Lay feather necklace out flat on a paper towel.
- Brush on a coat of Shimmer Fabric Paint onto each feather. Let dry and add additional coats as desired. Let dry completely.
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Best of 2012
I usually make a list of my 10 best games for a year, but to be honest, there just isn't enough outstanding games to make a full list this year. Most of the '' could have been '' games were indie experimentations, like Journey, Fez, FTL and Mark of the Ninja, which I loved, but not enough to warrant them a place amongst the best of this year. Having tested nearly 95% of 2012's relevant releases, I really can't find myself able to bring more than 5 games to the table this year. I would have loved to add Assassin's Creed 3, ME3, Hitman, Torchlight II and so on, but alas, none has enough merit.I felt like 2012 was a year that everybody wanted to avoid, especially with the numerous delays we had to endure. Maybe the end of the world scared some developers.


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The term wind chill says everything, and conciseness is of utmost importance when your lips are numbed cold:
"Late for work again, Bob?"
Serves 3-4
What you'll need:
1 lb of chuck beef cubes
6 carrots
5 stalks of celery
1 large white onion
3 cloves garlic - minced
1/4 tsp Season with Spice's bay leaf powder
2 of Season With Spice's Sri Lanka whole cloves
1 tsp salt, or to taste
1 tsp of freshly ground black pepper
3 cups of water
10 baby potatoes
3 tbsp flour
1. Place beef cubes on frying pan and cook on low until browned. Transfer beef and juice to a large pot (or slow cooker).
2. Cut carrots, celery, and onions into chunks. Add to pot (or slow cooker), along with garlic, bay leaf powder, cloves, salt, black pepper, and 3 cups of water.
3. Cover, and simmer on low fire for 3-4 hours.
4. Add baby potatoes to the pot. Simmer for one more hour, or until potatoes are softened.
5. Scoop out a bit of the broth into a small bowl. Mix in 3 tablespoons of flour. Then pour the mix back into the pot and stir well. Remove cover and cook on medium fire for another 20 minutes to slightly thicken the broth. Add in more salt and pepper if needed.
6. Serve hot by itself, or with a side of bread. A simple beef stew recipe with an amazing flavor - guaranteed to warm you during the coldest of Minnesota winter days.


text:
Sari Eckler Cooper | Posted 09.16.2014 | Entertainment
Read More: Sex Tape, Marriage, Cameron Diaz, Porn, Sex, Sexuality, Jason Segel, Alcohol and Sex, Entertainment News
In Sex Tape, the first hurtle seems to be the labor scene in which Jay watches his son's head crowning and comments more about the size of his wife's vaginal opening than on the miracle of his child entering the world.
It comes as no surprise that drinking lots of alcohol can lead to bad decision making. But up until recently, scientists had yet to find direct relationship regarding alcohol and unprotected sex.


text:
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Hudson Star Observer
New Houlton Elementary School principal selected
Hudson School District celebrates its own
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Walker mute on proposed 'life experience' teacher initiative; WDNR likely to lose 80 jobs; 10 more Wisconsin news stories
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SUMMONS:Unifund CCR v. Kimberleigh Lovell; Case No. 15-SC-322
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June 16, 2013
Afton's Strawberry Fest June 22-23
The Afton Strawberry fest will be held from from 10 a.m. to 5 p.m. Saturday, June 22, and 11 a.m. to 4 p.m. Sunday, June 23 in downtown historic Afton, Minn. The family-friendly event includes food, music, art, vendors and a European-style flea market. For more information, go to...
food / events
June 16, 2013 - 4:23am
June 14, 2013
Pie and ice cream social June 18 at New Centerville
New Centerville United Methodist Church, 36 County Road Y, east of River Falls is hosting a Pie & Ice Cream Social, 5-7:30 p.m. on Tuesday, June...
food / events
June 14, 2013 - 1:25pm
June 13, 2013
Relay for Life chair Charles Huntley survived colon cancer
In 2005, Charles Huntley went to the doctor because "something just didn't feel right." He got a call a day later from his doctor while he was...
health / events / life
June 13, 2013 - 9:17am
June 10, 2013
Join a band, the community band, rehearsals start this week
The St. Croix Valley Community Band rehearsals begins Thursday, June 13, at Hudson Middle School. Open to anyone interested in building community through music, the group rehearses Tuesday and Thursday evenings from 7-9 p.m. Four concerts are slated throughout the St. Croix Valley...
events / life
June 10, 2013 - 1:22pm
June 1, 2013
United Way's online auction features Paul McCartney tickets
United Way St. Croix Valley will be running its fourth annual online auction throughout the month of June. All proceeds generated by this year's...
events / life
June 1, 2013 - 10:13am
May 31, 2013
German Settlement Ice Cream Social June 9
The German Settlement Heritage Society is planning an old fashioned ice cream social Sunday, June 9, 3-6 p.m. at 837 County N, near Hudson. The event features rhubarb desserts and homemade ice cream. The old brick bake oven will be operating for those who wish to bake personal items....
food / events / life
May 31, 2013 - 9:43am
May 3, 2013
Hudson MS walk May 5
The National Multiple Sclerosis Society, Upper Midwest Chapter, will hold "Walk MS" on Sunday, May 5, at Hudson Middle School, 1300 Carmichael Rd. Check in will be held from 10-11 a.m., walkers can begin at 11 a.m. Participants can choose a 1- or 3.5 mile route. People can take part...
health / events / life
May 3, 2013 - 10:27am
Chad Wang benefit this weekend
A benefit at 5 p.m. Saturday, May 4, at the local American Legion Hall, 701 N.
health / events / life
May 3, 2013 - 8:53am
May 1, 2013
May Fair to benefit 4-H youth
Those looking for an evening of family fun should plan on attending the fourth annual May Fair Event and Sale on Saturday, May 11, at the St....
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May 1, 2013 - 1:03pm
April 25, 2013
A'laMode salonspa celebrates 15 year anniversary
A'laMode salonspa, 208 Locust St. in Hudson, is celebrating its 15-year anniversary this spring. Owner/President Boni LaVelle said the actual...
business / events
April 25, 2013 - 3:19pm
Octagon House opens for the season May 1
The Octagon House Museum opens for the 2013 tour season Wednesday, May 1. With this year's theme of "One House, One Family, One Hundred Years." Guests can get acquainted with the four generations of the Moffat-Hughes family who lived in the historic Octagon House. Learn about the...
events / life
April 25, 2013 - 10:34am
Cancer survivors honored with dinner May 2
All cancer survivors and their caregivers are invited to this year's Relay For Life Survivors' Dinner May 2 at Bethel Highlands. The annual event is a time to celebrate survivorship with those who share a common experience. This year's theme is "One Moment at a Time." According...
events / food / life
April 25, 2013 - 10:23am
'Pottery for Prevention' benefits Turningpoint
Pottery for Prevention, a benefit in support of Turningpoint for Victims of Domestic Abuse and Sexual Violence, will be held Saturday at The...
events / health / life
April 25, 2013 - 10:17am
April 24, 2013
Registration for Hudson summer swim program is Saturday
Registration for the Hudson School District's American Red Cross Learn to Swim Program is this Saturday, April 27, from 8-11 a.m. at the Hudson Middle School gym. The middle school doors will not be opened until 7 a.m. on Saturday. Fees are $20 per student per two-week session...
sports / events
April 24, 2013 - 10:02am
April 22, 2013
2013 Prom Court Crowned Saturday night
This year marked a significant change for the Hudson High prom attendees and their escorts. Prom was moved off campus. Parents, friends and...
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April 22, 2013 - 8:41pm
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Auckland, New Zealand
My Rating
Very Nice tour guides, helpful and knowledgable
Would book again
Auckland or Christchurch, New Zealand
My Rating
very nice trip
would book again!
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Welcome to the Lutheran Church in Great Britain ...
We are a growing church, with people from all parts of the world worshipping in our congregations.
We welcome in our midst all those who want to explore their faith and find a worshipping community.
As Lutherans we believe that we are saved by the grace of God and invited to gather around the Word of God and the Sacraments of Baptism and Holy Communion.
Find a service near you - click here for a list of LCiGB congregations.
From the Bishop, the Rt Revd Dr Martin Lind
LCiGB Signs Porvoo AgreementOn Friday, 19 September 2014, I signed the document stating that our Lutheran Church in Great Britain now is a full member of the Porvoo Communion. It all happened in the chapel in Bishopthorpe, the Palace of the Archbishop of York. The chapel was crowded with people as it is a rather small chapel. More
An easier and direct way to support LCiGB....
You can now make a direct donation to LCiGB via the CAF online site. Check for other ways to donate here.
New Office: We moved office on 1 March, 2014. The new address of LCiGB office is 30 Thanet Street, London WC1H 9QH, United Kingdom. Please send all your future correspondence to the new address.
The Lutheran Church in Great Britain Limited is a company registered in England and Wales, registered number 7034897, registered charity number 1137050. Registered Office: 30 Thanet Street, London WC1H 9QH. Tel: +44 (0)20 7383 0301


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Cheap RDD to Kivalina flights
Popular Flights from Redding, California
Top Redding Flights to US Destinations
Top Redding International Destinations
Popular Flights from Kivalina, Alaska
Top Kivalina Flights to US Destinations
RDD to KVL Route Map
Redding to Kivalina Flights, Stats and Airplanes
Route information for flights from Redding Municipal to Kivalina AK.
2,451.44 miles
RDD - Redding Municipal Airlines
Browse the most popular airlines servicing the Redding (RDD) airport. Visit their flights pages to learn more about the most popular routes these carriers fly.


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Property Details
House, 2 Bedrooms + Convertible bed(s), 1 Bath, (Sleeps 2-6)
Leave your troubles behind and bask in the beauty of nature. The National Park begins a short walk up the road. Enjoy stunning hiking trails into a desirable, but little known area of (south) Joshua Tree.
Perfect as a romantic couples getaway or for a group. By evening cozy up to a crackling fire. Cook your meals in the well-equipped kitchen and snuggle into soft covers by night. There are ample fresh linens for a party of six. In the morning sip fresh brewed coffee while staring into expansive vistas in every direction. The large picture windows overlook far away mountains and desert that can also be enjoyed from outdoor tables and chairs. This cozy two bedroom one bath house is all newly refurbished. Outdoor area includes barbecue.
Located near Harrison House, a straw bale artist retreat that is, at times, also available.
Keywords: Home
Recent Review
Lovely quiet desert hideaway
About the Owner
Filmmaker/Arts Producer who relocated to Joshua Tree from San Francisco to develop an artist-residency/performance program at 'Harrison House' which is situated across the way from 'Panorama Guest House.'
17 Reviews
4.8 based on 17 traveler reviews
Lovely quiet desert hideaway
Grea desert getaway
Style and Substance Meet Sublime Setting
Quiet Desert Getaway
A very nice home base for exploring the park
Calm out in the desert
From the Owner
"Desert View House has uninterrupted views of the mountains and desert. The 'locals' entrance 3/4 mile up the street to Joshua Tree National Park features some of the most beautiful hiking in the national park and is just a walk up the street. Desert View House is also located near the Harrison House Artist Residency and serves to house the artist overflow and guests who are visiting."
Activity and Interests
Panorama Heights is conveniently located just a few miles from downtown Joshua Tree on paved roads with scenic views and the border of Joshua Tree National Park within short walking distance. You are centrally situated between the East and West entrances to Joshua Tree National Park.
Rental rates
|Rate Period
|Weekend Night
|Monthly *
standard rate
Sep 15 2014 - Jun 18 2015
2 night minimum stay
|Notes: Rates are based on 2 guests; add $25 per night, per additional guest
My Standard Rate
2 night minimum stay
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.
Additional information about rental rates
- Refundable damage deposit $150.00
- Pet Fee $50.00
- Tax Rate 7.0%
$150 is for 2 people
$25/night for additional guests
refundable cleaning damage deposit of $150 will be collected with reservation.
Cancellation Policy
- 12
- Available
- 12
- Unavailable
- 12
- Today
From the Owner
"Location Location Location! Desert View House is convenient to the town of Joshua Tree, in between the two major entrances into the park and easy to access to the 'village of Joshua Tree' and the 29 Palms area where there are beautiful murals and restaurants to enjoy. In addition to hiking there is horse back riding, climbing and live musical performances nearby."
Property Type
- house
- Adventure
- Away From It All
- Family
- Historic
- Romantic
- Sports & Activities
- Tourist Attractions
- Air Conditioning ...
- Clothes Dryer
- Fireplace
- Heating ...
- Linens Provided
- Living Room
- Parking ...
- Parking Off Street
- Parking for RV/Boat/Trailer ...
- Towels Provided
- Washing Machine
- Wood Fireplace
- Coffee Maker
- Cooking Utensils
- Dishes & Utensils
- Dishwasher
- Kitchen
- Microwave
- Oven ...
- Pantry Items
- Refrigerator
- Stove ...
- Toaster
- Dining Area
- Books
- CD Player
- DVD Player
- Music Library
- Stereo
- Video Library
Pool / Spa
- Hot Tub ...
- Long-term Renters Welcome
- Minimum Age Limit for Renters ...
- children welcome
- non smoking only
- pets not allowed
Location Type
- Monument View
- Mountain View
- churches
- cinemas
- festivals
- library
- live theater
- restaurants
Leisure Activities
- antiquing
- bird watching
- eco tourism
- horseback riding
- scenic drives
- shopping
- sight seeing
- walking
- wildlife viewing
Local Services & Businesses
- ATM/bank
- groceries
- hospital
- laundromat
- massage therapist
- medical services
Sports & Adventure Activities
- cycling
- hiking
- mountain biking
- mountain climbing
- rock climbing
Floor Area
- 1020 sq. ft.
- 1 Bathroom
- Bathroom 1
- Tub/Shower
- 2 Bedrooms, Sleeps 6
- Bedroom 1 - 1 king
- Bedroom 2 - 1 queen
- Convertible bed(s) - 1 double
- Queen size Beds (1), Double Beds (1), Sleep Sofa or Futons (1)
- Deck / Patio
- Outdoor Grill
- Guests provide their own meals
Learn more about this vacation rental at the owner's website
- Walking distance to border of Joshua Tree National Park and beautiful hiking.


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|Property type
|Minimum Stay
|5 - 7 nights
The ultimate in Madeira self catering accommodation,this magnificent Ponta do Sol holiday villa can house as few as 2guests or as large as 10guests+2infants in cots.You have a heated outdoor pool,a jacuzzi,games room,large terraced areas and gardens (with/without shade) with sun loungers that provide well-deserved rest at the sound of birds chirping.Completed in 2008,it's owner has provided 5star luxury throughout -you will lack nothing!This luxurious,private,sunny villa is superbly equipped with accommodation on two floors offering exceptional comfort. The lounge and dining room are spacious with extensive windows leading to the south-facing terrace area equipped with loungers, dining table and chairs, BBQ and heated outdoor pool - perfect for indoor/outdoor living.An immaculate villa, beautifully maintained and superbly located-handy for the expressway,buses,restaurants,pharmacy,ATM,health center.Maid service is provided by friendly Mrs. Graça.Perfect for discerning holidaymakers.
How to get to Casa do Retiro?: First of all take the speed way (VR1) in direction to Funchal.
Near Funchal you'll find signage Ribeira Brava. Stay this way to Ribeira Brava. Arriving Ribeira Brava (in the end of the big tunnel) turn right and you'll find a roundabout. Take the first exit going towards to the center of the village. After entering Gesteiro's tunnel you'll find a second roundabout. Take the first exit right, in direction to Ponta do Sol. You'll enter another tunnel and you'll find a third roundabout. Take the second exit to Lugar de Baixo. Cross this village. After one more tunnel you'll find another roundabout Take the first exit right - Paúl da Serra Canhas. Cross this street untill you find the last roundabout. Take the fourth exit (Paúl da Serra Canhas) and after 4,6 km in the main street you'll find Santa Teresinha's monument, with 3 stone achs. After this monument, turn right and you'll find Casa do Retiro's gate on the right side properly marked.
PONTA DO SOL: Ponta do Sol is located on the south coast of Madeira Island, known for its sunny climate. Ponta do Sol has restored old buildings in a maze of quiet and welcoming streets. The calm and beautiful village situated in a steep valley with dense banana plantations The village of Ponta do Sol is one of the most picturesque of the island of Madeira and has incredible sunsets.
Located in Lugar de Baixo, Ponta do Sol, at an average altitude of 40 meters is the center of subtropical flowers. With 2 hectares of area it is the ideal place to grow and study subtropical plants. Lugar de Baixo is one of the most famous surf areas of Madeira Island.
Casa do Retiro was created as a Family business. Our passion is to receive travellers all around the world in our villas and welcome them and make them feel they're home! We work hard together to assure our guests have the most luxurius stays in the most idilic places - Madeira Island and Porto Santo Island.
We bought this land because our family grew there. The monument in front of our villa was built by our grand mother in order to honor all women who have breast cancer because herself survived after being diagnosed with breast cancer in a young age.
During the week of easter, we had a lovely time in Casa Do Retiro. We were six adults and four kids and felt there were lot of space in the beautiful house and garden. Everything were perfect and there was everything we needed. The pool was nice and clean and the same with the jacusi. We got an amazing welkome of the owners and speciel thanks to the very nice house keeper who made the stay very easy and comfortable . If we get the possibility once again, we would like to come back. We give our best recommendations to the owners and the house.
Carsten and Else Marie from Denmark
We have just returned from a second fantastic week in this holiday home. This is the first time we have ever decided to return to the same place on holiday, which I think speaks volumes about this wonderful house. This time we not only went with our 3 children (10,8 and 6) but also my Father and Mother-in-law, who also loved it. There was plenty of space for us all. The pool heating, along with sunny weather let us swim every day in February! The hot tub was a lovely treat after a swim. The gardens are beautiful and relaxing with the birds chirping and gorgeous views down to the sea. The game room provided lots of entertaining games of pool and table football. We enjoyed a barbecue and eating outside, but equally cosy evenings by the log fire, with the Madeira wine and Honey cake which was left for us. Mrs Garcia does a super job of cleaning every day, keeping the villa immaculate. The villa is in a super location for exploring the island - Funchal, the North coast and several walks are all within a half hour's drive. The Pizzaria/takeaway, supermarket, bank and children's play area were all used as they are literally a 2 minute walk away. In fact, the only downside is that we really want to keep this gem of a house secret, so it is available when we next want to book it...
We recently spent a most enjoyable sixteen days in Casa do Retiro.
We had carefully selected the villa from a number of villas on different web sites and this one stood out immediately as the one we would like to stay in.
And after also taking into account the glowing reviews the house has received we can only say that our expectations were more than realised.
The house is a large and very comfortable one, with many personal touches of the Noronha family. The family itself, Tito and Christina, were present in person as we arrived, together with M. Graça, who very discreetly cleans the house and does the washing and washing up on a daily basis. They gave us a very warm welcome indeed and showed us round the house in person explaining the history of the family. It was very clear that they were proud to be able to show us their house and share it with us. Christina had also prepared a wonderful bowl of fruit and a bottle of Madeira wine as a welcome. Later on during the first week she also brought us a genuine Madeira home-made bolo de mel cake which was absolutely delicious. She even shared her recipe with us.
The house was in tip-top condition and when we noticed that the kettle was leaking it was replaced the next day!
In the end we counted ourselves lucky that our return flight was delayed by three days, giving us an extra three days in this wonderful villa.
The villa is situated on the south coast of Madeira and is ideally placed to access many interesting places. We especially remember our trip from Sao Vicente to Santana for its absolutely breath-taking scenery along the north coast. The narrow road with its many twists and turns is not for the faint-hearted though!
We have stayed in villas in Crete, Italy, Portugal, Spain and France over the last ten years but this villa was unmatched by any of them.
Thank you Tito, Christina and M. Graça for giving us such a wonderful time!
We thought that this rental looked too good to be true - and yet our stay at Casa Do Retiro surpassed our expectations. We are already looking forward to our return visit, having just got home.
It is a challenge to find a relaxing holiday with two young children (one nearly 4, the other almost 18 months) and although opting for a villa was going to provide the flexibility we wanted, we were a little concerned that we would sacrifice on relaxation. We should not have worried - the family did everything possible to prepare the house for our arrival (even getting a couple of new steps for our eldest daughter to access the sinks and toliets), providing a huge array of drinks and fresh, exotic local fruits and setting up cots in a number of bedrooms so we could choose the best space (our daughters loved sharing the pink room). Beatriz even organised a birthday party for my husband, much to the delight of him and our girls, and the amazing themed cake lasted the whole 10 days!
Furthermore, the housekeeper, Mrs Graca, discreetly took care of washing up and washing (our daughters created lots!) as well as cleaning, giving us a proper rest. She even set up a matress and blankets on the floor next to the bed in case our eldest rolled out during the night (but she slept better than she's ever slept before!)
We can honestly say that we have not enjoyed such a relaxing, refreshing holiday since before our children were born. There is plenty to see and do on the island (highlights included cable car in Funchal, long lazy lunch near Santana, agapanthus and eucalyptus forests on the way to the Paul de Serra, pools at Santa Moniz, summit of the second highest mountain), the food is delicious (Apollo in Funchal, pizzas from around the corner, sea food at the beach bars in Ponta Do Sol and Calheta) and the people are welcoming and friendly (making a lovely fuss of the little ones).
The house itself is a privilege to stay in; a very warm place because of the inspiring family history.
It is a testimony to the owners of the house, to Mrs Graca, and to the unspolit natural beauty of Madeira itself that our days were filled with fun and our nights were longer than we could possibly have hoped for. The action-packed days and blackout curtains even gave us a number of long lie-ins. What more could a family with young children ask for!
We would not hesitate in recommending this property - provided that we can still get a booking when we next need to recharge!
A wonderful villa with beautiful furniture, very personal things from the family's history and every comfort you could whish for. The house is exactly as you can see on the photos. We were met by the owners who gave us an exceptional warm welcome. We got maderian wine and cake, a lot of delicious fruits and everything we need for the first breakfast. The daily housekeeping by Mrs. Graca was disreet and very efficient. The villa is perfectly located. The island is good for walking-tours, but sometimes it's difficult to find the way. We enjoyed very much playing golf (Clube de Golf do Santo da Serra and Palheiro Golf).
A fabulous house. Really well appointed throughout with many classy touches. Beautiful furniture, comfortable beds, superb kitchen and every amenity you could wish for. Tito, Christina and Martim make you genuinely feel part of their family. Mrs Garcia cleaned the house every day, to include replacing towels and linen.
Swimming pool and jacuzzi were well used as was the snooker table and beautiful outside BBQ - all wood supplied. To sit outside enjoying a BBQ meal in the evening in November was a pleasure.
Supermarket, restaurant, banks, pharmacy literally on the doorstep.
My wife had an accident and badly sprained her ankles. Tito and Martim spent 4 hours at the hospital with us to make sure we had all the support we needed.We were indeed part of the family for the week.
Beautiful island, beautiful people, beautiful house. Worth every penny!!
Casa do Retiro is located in the South Coast of Madeira Island, in sunny and peaceful village of Canhas, in Ponta do Sol. It is equidistant from everywhere because it is in the middle of South Coast (wich has the best weather of the island) so it is nearby everything! It is located 5 minutes from center of Ponta do Sol with easy access to beaches and restaurants in the area. It's located 12 km from Paúl da Serra, a perfect local for hiking in Calheta's and Ponta do Sol's water courses called 'levadas'. Casa do Retiro is also only 15 minutes from Funchal City and about 40 minutes from Madeira International Airport.
The village of Ponta do Sol has it's own beach. The neighbor village of Calheta has a golden sandy beach.
The villa is very well located and 150 meters from a supermarket, pharmacy, ATM, bank, church, health center, clinical dentist, restaurants and coffees.
On Sundays there is a very intersting local agricultural market with local fresh products from 10 am until 14 pm.
Other Activities: Calheta and Ponta do Sol Levadas (watercourses), Agricultural Market place
Golf: Two championship courses, Palheiro and Santo da Serra, are within 20 minutes drive and offer challenging golfing amongst spectacular scenery.
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Monthly *
|Event Price
Época Média
1 May 2015 - 30 Jun 2015
5 night minimum stay
for 5 nights
|Notes: Rates are based on 2 guests; add €17 per night, per additional guest
Verão 2015
1 Jul 2015 - 31 Aug 2015
7 night minimum stay
for 7 nights
|Notes: Rates are based on 2 guests; add €17 per night, per additional guest
Época Média
1 Sep 2015 - 31 Oct 2015
7 night minimum stay
for 7 nights
|Notes: Rates are based on 2 guests; add €17 per night, per additional guest
Época Baixa
1 Nov 2015 - 17 Dec 2015
5 night minimum stay
for 5 nights
|Notes: Rates are based on 2 guests; add €17 per night, per additional guest
Natal & Fim-do-ano 2015
18 Dec 2015 - 5 Jan 2016
7 night minimum stay
for 7 nights
|Notes: Rates are based on 2 guests; add €18 per night, per additional guest
Época baixa
6 Jan 2016 - 18 Mar 2016
5 night minimum stay
for 5 nights
|Notes: Rates are based on 2 guests; add €18 per night, per additional guest
Páscoa 2016
19 Mar 2016 - 27 Mar 2016
5 night minimum stay
for 5 nights
|Notes: Rates are based on 2 guests; add €18 per night, per additional guest
Época Baixa
28 Mar 2016 - 30 Apr 2016
5 night minimum stay
for 5 nights
|Notes: Rates are based on 2 guests; add €18 per night, per additional guest
Época Média
1 May 2016 - 30 Jun 2016
5 night minimum stay
for 5 nights
|Notes: Rates are based on 2 guests; add €18 per night, per additional guest
My Standard Rate
7 night minimum stay
for 7 nights
|Notes: Rates are based on 2 guests; add €17 per night, per additional guest
|Limpeza final
Estadias INFERIORES à ESTADIA MÍNIMA (7 noites), o valor diário para 2 hóspedes passa a ser de €133,00, €140,00, €147,00 dependendo da época (baixa, média ou alta respectivamente). Os preços por hóspede extra mantém-se.
O aquecimento da piscina permite uma temperatura da água da piscina entre os 25 e os 27 ºC. É o único extra da casa e tem um custo de 18,00€/dia.
* Approximate monthly price. Actual pricing will depend on the days of the month you stay.
Please Note: The owner of this property accepts payment in the original currency specified (EUR), before use of conversion tool. The conversion tool is provided for your convenience only. The owner may accept other currencies if specifically agreed in advance.


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Daemen College : Academics & Research : Division of Arts & Sciences : Visual & Performing Arts : Animation : International Partners
Max the Mutt and Daemen College first entered into a collaborative effort in May of 2010. Both schools will support and enhance each other's animation programs and plan to cooperate in developing innovative educational strategies that will enhance the development of students at both schools.
Max the Mutt and Daemen are well matched: both stress small class size, foster skills and creativity, seek to develop knowledge and skills that will make their graduates a positive addition to their fields and to the world. Max the Mutt and Daemen will also offer relevant workshops to each other's students.
Daemen College's LEADS Center provides leadership development, provides and encourages the development of consciousness of self, fosters inclusive collaborative relationships, social change, and civic responsibility.
©2014 Daemen College : 4380 Main Street, Amherst, NY 14226 : 800.462.7652


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Select Local Merchants
Shawn's Pumpkin PatchRead MoreThe squash-savvy staff at Shawn's Pumpkin Patch flaunts a cornucopia of variously sized pumpkins to adorn fall festivities. Against a rustic backdrop of straw bales and cornstalks, pyramids of gigantic, medium, small, and mini pumpkins ($1?$80) sit ready to be taken home and carved to mimic the visage of a zombie or a beloved imaginary friend. Although not included in today's Groupon, Shawn's Pumpkin Patch also hosts pony rides, mini-train trips, and a petting zoo ($3?$6/person).5750 Mesmer AveCulver City, CA US
iFly HollywoodRead MoreiFLY Hollywood's state-of-the-art indoor wind tunnel lets acrophobic and aerophobic adrenaline junkies experience the sensations of skydiving under safe conditions. iFLY Hollywood will suit you up with a helmet, goggles, flight suit, earplugs, and a can of gravity repellent, before an instructor teaches you the basic maneuvers and hand signals. Once you've learned a lesson, you'll be unleashed into the vertical tunnel's artificial wind current for some air time at terminal velocity. The entire process lasts about an hour, including waiver signing (flyers under 18 must have a parent or guardian sign), a 15-minute class, and a flight slot during which your group takes turns flying. In addition to the flight experience, the multimedia package includes a DVD with a recording of your flight. Indoor skydiving is accessible to a wide, family-friendly age range, meaning that Grandma and Grandpa can celebrate their 60th anniversary with more than the traditional cake shaped like Andy Griffith. iFLY Hollywood's free observation deck allows for maximum show-offiness, so invite along an audience of hard-to-impress friends, lovers, and butlers to marvel at your simulated plummet through the heavens.100 Universal Studios Blvd, Bldg 6520Universal City, CA US
Universal Studios EntertainmentRead MoreIn Jurassic Park – The Ride, a 50-foot tyrannosaurus rex chases down your vehicle before it plunges 84 feet in a surge of 1.5 million gallons of water. This thrill joins the park's other exciting attractions based on such blockbusters as The Mummy and Transformers.100 Universal City PlazaUniversal City, CA US
Castle Park Monterey ConsesionsRead MoreThe metallic clunks of baseballs and softballs struck by swinging bats pulse through Castle Batting Cages, located inside Sherman Oaks Castle Park. The hurling apparatuses serve up these ill-fated spheres at speeds as low as 20 miles per hour and as high as 80 miles per hour. The slow-pitch-softball machines toss both low-arc and high-arc strikes, and the fast-pitch-softball cage tests reflexes with speeds of up to 60 miles per hour.4989 Sepulveda BlvdSherman Oaks, CA US
Pacific ParkRead MorePacific Park?s attractions celebrate Santa Monica Pier?s history with classic rides that run with modern technology. The Pacific Wheel uses solar energy to circle 130 feet into the air, where fist pounds from the man in the moon and scenic views of the coastline await. The energy-efficient attraction is 1 of 12 rides, which include classics, a roller coaster, and a four-story tower drop. Visitors can earn prizes at midway games, refuel at the food court, and get their adrenaline pumping on the rock wall or beach bounce.Santa Monica Pier - Pacific Park, 380 Santa Monica PierSanta Monica, CA US
Warner Bros StudioRead MoreShowcasing some 60,650 time-treasured titles, Warner Bros. Studios boasts one of the largest libraries of feature films, television, and animated pictures. Cozy up with a maternal maven this Mom's Day for a four-movie marathon of Blu-ray flicks designed to jerk tears and reveal stories about actual jerks she once dated in college. Uncover shared high-school experiences with a screening of 17 Again, a magical, life-swapping jaunt starring Zac Efron and Matthew Perry, or collectively swoon as Nights in Rodanthe smolders with on-screen chemistry between Richard Gere and Diane Lane. Comedy-loving creators and their cubs can crack up amid the capering crusades of Jim Carrey in Yes Man, and a spontaneous viewing of He's Just Not That Into You can help explain the Easter Bunny's prolonged tardiness to a curious college student.3400 West Riverside DriveBurbank, CA US


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Bluegrass Music
This wide-reaching genre encompasses parts of folk and other indigenous, American roots musics. Often featuring acoustic arrangements and minimal percussion, Americana tends to include banjos, mandolins, fiddles and other stringed instruments. More current bands working within the genre include Chatham Country Line and Nickel Creek. Browse through top-rated Bluegrassbands and artists.