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http://cancer.ucsf.edu/news http://ti.ucsf.edu/element/auje3xj 25 auje3xj 1 2015-05-23 01:47:53 EDT 2015-05-23 01:47:53 ti.ucsf.edu http://ti.ucsf.edu News list 819 2011-12-22 17:17:08.434418-06 public UCSF Today article 1 3 http://ti.ucsf.edu/element/auje3xj/counter/819 2011-12-22 17:17:07-06 http://today.ucsf.edu/stories/personalized-vaccines-to-fight-brain-cancer/ UCSF neurosurgeon <a href="people/parsa_andrew.php">Andrew Parsa, MD, PhD</a>, is running a clinical trial on patients with glioblastoma multiforme, the most deadly type of brain tumor, using a vaccine made from the patient's own tumor to trigger the immune system.<br><br>In the clinical trial, Parsa first removes as much of the tumor as he can, and then sends it to a biotech company where a vaccine, Oncophage, is created from an individual tumor's healthy protein, then injected back into the same patient. Using a proprietary manufacturing process, the heat shock protein gp96 and its associated peptides are isolated from the tumor. The complexes are extracted and purified from each sample, then sterilely filtered and placed into vials. The final product is subject to extensive quality-control testing, including sterility testing of each lot. The vaccine is shipped frozen back to the hospital pharmacy for use when the patient has recovered from surgery.<br><br>"Our hope is that by using our vaccines, we can make the immune system of the patient fight the cancer and, by fighting the cancer, we can give them a long-term cure," Parsa said. "It's exciting. We're seeing something for the first time. It's like man walking on the moon." When the tumor is removed, Parsa said the space it leaves fills up with spinal fluid. He said each customized vaccine would only work on the patient it came from. 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2007/02/07/personalized-vaccines-to-fight-brain-cancer.819 /ics/2007/02/07/personalized-vaccines-to-fight-brain-cancer.819/personalized-vaccines-to-fight-brain-cancer.819.ics 819 left 1 1 1543 2/7/2007 2007-02-07 09:36:00 9:36 am PST left 16163 ucsf/news_import.pl 1 1 1 UCSF neurosurgeon Andrew Parsa, MD, PhD, is running a clinical trial on patients with glioblastoma multiforme, the most deadly type of brain tumor, using a vaccine made from the patient's own tumor to trigger the immune system. In the clinical trial, Parsa first removes as ... UCSF neurosurgeon Andrew Parsa, MD, PhD, is running a clinical trial on patients with glioblastoma multiforme, the most deadly type of brain tumor, using a vaccine made from the patient\'s own tumor to trigger the immune system.In the clinical trial, Parsa first removes as ... 2/7/2007 9:36 am PST US/Pacific Personalized Vaccines to Fight Brain Cancer Personalized Vaccines to Fight Brain Cancer personalized-vaccines-to-fight-brain-cancer.819 /2007/02/07/personalized-vaccines-to-fight-brain-cancer.819 820 2011-12-22 17:17:09.463383-06 public Jennifer O'Brien, UCSF News Services article 1 3 http://ti.ucsf.edu/element/auje3xj/counter/820 2011-12-22 17:17:09-06 http://today.ucsf.edu/stories/insights-into-p53-tumor-suppressor-gene-to-fuel-cancer-strategy/ UCSF scientists are reporting key insights into the p53 tumor-suppressor gene that they say should help harness the gene to treat cancer.<br><br>The gene is disabled in most forms of the disease, and its loss is often associated with increased malignancy, resistance to treatment and decreased patient survival.<br><br>Scientists have long considered restoration of the p53 gene a possible therapeutic strategy. However, they have not known whether restoring the gene would lead to its activation or what impact, if any, such activation would have on established tumors -- until now.<br><br>In a unique model of p53 signaling, UCSF scientists restored the gene in the tumor cells of mice with established lymphoma. The initial results were dramatic.<br><br>"The tumors were completely dead within hours," says senior author <a href="people/evan_gerard.php">Gerard I. Evan, PhD</a>, the Gerson and Barbara Bass Bakar Distinguished Professor of Cancer Research at the UCSF Comprehensive Cancer Center. The animals also survived significantly longer than mice in which p53 had not been activated.<br><br>"These results demonstrate that signals exist in established lymphomas that can engage and trigger p53," he says. "All the machinery is there -- all the signals leading to p53 -- and all the machinery downstream of p53 that can destroy cancer cells is in place. The only thing missing is p53 itself. Restoring p53 in these tumor cells is like engaging the clutch in your car -- it reconnects the cancer-sensing 'engine' to the cell death 'transmission.'<br><br>"This result is very good news to the many of us who are thinking about trying to restore p53 function in established human cancers."<br><br>At the same time, he notes, the tumors eventually re-emerged in all of the mice. The team analyzed how this occurred, and identified tactics for optimizing the gene's therapeutic impact.<br><br>(Note that in November 2007 the UCSF Comprehensive Cancer Center was renamed the UCSF Helen Diller Family Comprehensive Cancer Center.) 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2007/01/26/insights-into-p53-tumor-suppressor-gene-to-fuel-cancer-strategy.820 /ics/2007/01/26/insights-into-p53-tumor-suppressor-gene-to-fuel-cancer-strategy.820/insights-into-p53-tumor-suppressor-gene-to-fuel-cancer-strategy.820.ics 820 left 1 1 1544 1/26/2007 2007-01-26 09:33:00 9:33 am PST left 16161 ucsf/news_import.pl 1 1 1 UCSF scientists are reporting key insights into the p53 tumor-suppressor gene that they say should help harness the gene to treat cancer. The gene is disabled in most forms of the disease, and its loss is often associated with increased malignancy, resistance to treatment and ... UCSF scientists are reporting key insights into the p53 tumor-suppressor gene that they say should help harness the gene to treat cancer.The gene is disabled in most forms of the disease, and its loss is often associated with increased malignancy, resistance to treatment and ... 1/26/2007 9:33 am PST US/Pacific Insights into p53 Tumor-Suppressor Gene to Fuel Cancer Strategy Insights into p53 Tumor-Suppressor Gene to Fuel Cancer Strategy insights-into-p53-tumor-suppressor-gene-to-fuel-cancer-strategy.820 /2007/01/26/insights-into-p53-tumor-suppressor-gene-to-fuel-cancer-strategy.820 821 2011-12-22 17:17:10.498951-06 public UCSF Today article 1 3 http://ti.ucsf.edu/element/auje3xj/counter/821 2011-12-22 17:17:10-06 http://today.ucsf.edu/stories/health-disparities-expert-named-chair-of-department-of-radiation-oncology/ <a href="people/roach_mack.php">Mack Roach III, MD</a>, professor of radiation oncology and urology, has been named chair of the Department of Radiation Oncology.<br><br>"Dr. Roach is recognized as one of America's leading authorities on the use of radiation to treat localized prostate cancer and as a prominent crusader against health care disparities," says David Kessler, MD, dean of the UCSF School of Medicine and vice chancellor for medical affairs.<br><br>Roach has served the department as director of clinical research since 2001, as vice chair since 2003 and as interim chair since January 2006.<br><br>The selection was made after a nationwide search by a committee led by Margaret Tempero, MD, chief of medical oncology.<br><br>Roach led one of the most important prospective randomized RTOG (Radiation Therapy Oncology Group) trials involving radiation therapy, one that demonstrated the value of pelvic nodal radiotherapy for patients with high-risk prostate cancer, Kessler noted in his announcement of the appointment. Roach is also considered to be a pioneer in the use of 3D-conformal-intensity modulated radiotherapy and in image-guided radiotherapy, having popularized the use of online portal imaging. 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2007/01/22/health-disparities-expert-named-chair-of-department-of-radiation-oncology.821 /ics/2007/01/22/health-disparities-expert-named-chair-of-department-of-radiation-oncology.821/health-disparities-expert-named-chair-of-department-of-radiation-oncology.821.ics 821 left 1 1 1545 1/22/2007 2007-01-22 09:31:00 9:31 am PST left 16160 ucsf/news_import.pl 1 1 1 Mack Roach III, MD, professor of radiation oncology and urology, has been named chair of the Department of Radiation Oncology. "Dr. Roach is recognized as one of America's leading authorities on the use of radiation to treat localized prostate cancer and as a prominent crusader ... Mack Roach III, MD, professor of radiation oncology and urology, has been named chair of the Department of Radiation Oncology."Dr. Roach is recognized as one of America\'s leading authorities on the use of radiation to treat localized prostate cancer and as a prominent crusader ... 1/22/2007 9:31 am PST US/Pacific Health Disparities Expert Named Chair of Department of Radiation Oncology Health Disparities Expert Named Chair of Department of Radiation Oncology health-disparities-expert-named-chair-of-department-of-radiation-oncology.821 /2007/01/22/health-disparities-expert-named-chair-of-department-of-radiation-oncology.821 822 2011-12-22 17:17:11.520016-06 public Jeffrey Norris, UCSF Science Cafe article 1 3 http://ti.ucsf.edu/element/auje3xj/counter/822 2011-12-22 17:17:11-06 http://www.ucsf.edu/science-cafe/articles/alternatives-to-surgery-and-radiation-for-prostate-cancer/ Due to aggressive prostate cancer screening, more men than ever before are being diagnosed with small, low-grade tumors that may pose little immediate threat.<br><br>Oncologists are offering some of these men close monitoring -- called active surveillance -- without any immediate treatment. Why not treat? Some prostate tumors may never progress significantly, and both surgery and radiation pose the risk of impotence, incontinence and other side effects.<br><br>But many men are uncomfortable about only being monitored while hoping that their low-risk tumors never grow. So clinical researchers are exploring noninvasive interventions that might further lower the odds that untreated tumors will turn nasty. Can Diet and Lifestyle Affect Prostate Cancer Outcome?<br><br><a href="people/chan_june.php">June Chan, PhD</a>, epidemiologist for the UCSF Comprehensive Cancer Center's Prostate Cancer Program, is addressing a session on nontoxic interventions at a symposium on active surveillance of prostate cancer on January 12 and 13 at UCSF's Mission Bay campus.<br><br>Chan and <a href="people/carroll_peter.php">Peter Carroll, MD</a>, chair of urology, associate dean and director of clinical services for the UCSF Comprehensive Cancer Center, lead a National Cancer Institute-funded UCSF clinical trial called MENS -- Molecular Effects of Nutritional Supplements.<br><br>(Note that in November 2007 the UCSF Comprehensive Cancer Center was renamed the UCSF Helen Diller Family Comprehensive Cancer Center.) 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2007/01/11/alternatives-to-surgery-and-radiation-for-prostate-cancer.822 /ics/2007/01/11/alternatives-to-surgery-and-radiation-for-prostate-cancer.822/alternatives-to-surgery-and-radiation-for-prostate-cancer.822.ics 822 left 1 1 1546 1/11/2007 2007-01-11 09:29:00 9:29 am PST left 16159 ucsf/news_import.pl 1 1 1 Due to aggressive prostate cancer screening, more men than ever before are being diagnosed with small, low-grade tumors that may pose little immediate threat. Oncologists are offering some of these men close monitoring -- called active surveillance -- without any immediate treatment. Why not treat? Due to aggressive prostate cancer screening, more men than ever before are being diagnosed with small, low-grade tumors that may pose little immediate threat.Oncologists are offering some of these men close monitoring -- called active surveillance -- without any immediate treatment. Why not treat? 1/11/2007 9:29 am PST US/Pacific Alternatives to Surgery and Radiation for Prostate Cancer Alternatives to Surgery and Radiation for Prostate Cancer alternatives-to-surgery-and-radiation-for-prostate-cancer.822 /2007/01/11/alternatives-to-surgery-and-radiation-for-prostate-cancer.822 823 2011-12-22 17:17:12.551143-06 public Jeffrey Norris, UCSF Science Cafe article 1 4 http://ti.ucsf.edu/element/auje3xj/counter/823 2011-12-22 17:17:12-06 http://www.ucsf.edu/science-cafe/articles/prostate-cancer-who-needs-treatment/ Many men with early-stage prostate cancers may be undergoing treatment unnecessarily with surgery or radiation, according to a leading prostate cancer surgeon.<br><br>Heads-up diagnosis and treatment have undoubtedly played an important role in decreasing deaths due to prostate cancer. But even so, "about half the men currently being treated for prostate cancer have low-risk disease," says <a href="people/carroll_peter.php">Peter Carroll, MD</a>, chair of urology at UCSF. Some of these men may never need treatment.<br><br>Carroll also is clinical director of one of 11 collaborating centers nationwide that are funded by the National Cancer Institute (NCI) to conduct innovative prostate cancer research, heads a committee that is revising screening guidelines for the American Urological Association, and is principal investigator for CaPSURE, a longitudinal observational study of prostate cancer patients nationwide.<br><br>Carroll and leading experts from across the nation and overseas are convening at UCSF's Mission Bay campus on Jan. 12 and 13 to discuss how to arrive at better guidelines about who needs treatment - and when - among the increasing number of men being diagnosed with early-stage prostate cancer.<br><br>These international clinical and research leaders aim to develop a new research agenda, as well as new approaches to collaborating on and sharing research data across national boundaries. 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2007/01/10/prostate-cancer-who-needs-treatment.823 /ics/2007/01/10/prostate-cancer-who-needs-treatment.823/prostate-cancer-who-needs-treatment.823.ics 823 left 1 1 1547 1/10/2007 2007-01-10 09:27:00 9:27 am PST left 16158 ucsf/news_import.pl 1 1 1 Many men with early-stage prostate cancers may be undergoing treatment unnecessarily with surgery or radiation, according to a leading prostate cancer surgeon. Heads-up diagnosis and treatment have undoubtedly played an important role in decreasing deaths due to prostate cancer. But even so, "about half the ... Many men with early-stage prostate cancers may be undergoing treatment unnecessarily with surgery or radiation, according to a leading prostate cancer surgeon.Heads-up diagnosis and treatment have undoubtedly played an important role in decreasing deaths due to prostate cancer. But even so, "about half the ... 1/10/2007 9:27 am PST US/Pacific Prostate Cancer -- Who Needs Treatment? Prostate Cancer -- Who Needs Treatment? prostate-cancer-who-needs-treatment.823 /2007/01/10/prostate-cancer-who-needs-treatment.823 824 2011-12-22 17:17:13.576343-06 public California HealthCare Foundation article 1 4 http://ti.ucsf.edu/element/auje3xj/counter/824 2011-12-22 17:17:13-06 http://www.chcf.org/press/view.cfm?itemID=128428 UCSF Breast Cancer Center Chosen to Design and Test Innovative, Consumer-Centered Personal Health Record<br><br>The Carol Franc Buck Breast Care Center at the University of California, San Francisco (UCSF) will play a key role in a program to help consumers use information technology to better manage their health and navigate the health care system. Funding for the $300,000 UCSF project will come from the California HealthCare Foundation (CHCF).<br><br>Under the direction of <a href="people/esserman_laura.php">Laura Esserman, MD, MBA</a>, the UCSF team, one of nine chosen from a pool of more than 165 applicants by the Robert Wood Johnson Foundation, will design an application that builds a customized care plan for patients diagnosed with breast cancer.<br><br>The UCSF team and the other eight teams will work collaboratively to design and test a suite of personal health record (PHR) applications that can be built upon a common platform to help people better meet their health care needs in an integrated fashion. Such tools may remind a patient to take medications, provide tailored decision prompts to help people understand and adhere to treatment regimens for specific conditions or pain therapy, or transmit data to providers. 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2006/12/21/ucsf-chosen-to-design-and-test-innovative-consumer-centered-personal-health-record.824 /ics/2006/12/21/ucsf-chosen-to-design-and-test-innovative-consumer-centered-personal-health-record.824/ucsf-chosen-to-design-and-test-innovative-consumer-centered-personal-health-record.824.ics 824 left 1 1 1548 12/21/2006 2006-12-21 08:44:00 8:44 am PST left 16155 ucsf/news_import.pl 1 1 1 UCSF Breast Cancer Center Chosen to Design and Test Innovative, Consumer-Centered Personal Health Record The Carol Franc Buck Breast Care Center at the University of California, San Francisco (UCSF) will play a key role in a program to help consumers use information technology to better ... UCSF Breast Cancer Center Chosen to Design and Test Innovative, Consumer-Centered Personal Health RecordThe Carol Franc Buck Breast Care Center at the University of California, San Francisco (UCSF) will play a key role in a program to help consumers use information technology to better ... 12/21/2006 8:44 am PST US/Pacific UCSF Chosen to Design and Test Innovative, Consumer-Centered Personal Health Record UCSF Chosen to Design and Test Innovative, Consumer-Centered Personal Health Record ucsf-chosen-to-design-and-test-innovative-consumer-centered-personal-health-record.824 /2006/12/21/ucsf-chosen-to-design-and-test-innovative-consumer-centered-personal-health-record.824 825 2011-12-22 17:17:14.611803-06 public Nancy Chan, UCSF Today article 1 4 http://ti.ucsf.edu/element/auje3xj/counter/825 2011-12-22 17:17:14-06 http://today.ucsf.edu/stories/lung-cancer-survivors-find-reason-for-hope/ In a room overflowing with people at the UCSF Comprehensive Cancer Center, <a href="people/jablons_david.php">David Jablons, MD</a>, professor and chief of thoracic surgery, gave the audience, many of whom are patients under his care, a reason to hope.<br><br>"We are making progress -- there are exciting sciences that are being advanced," said Jablons. "With early detection, lung cancer is curable. We canit accept the status quo that only 15 percent survive five years and only 5 percent survive 10 years."<br><br>Jablons cited a landmark study recently published in the New England Journal of Medicine by Claudia Henschke, MD, PhD, and David Yankelevitz, MD, the founders and principal investigators of the International Early Lung Cancer Action Program. Results from the 13-year study on screening for lung cancer demonstrated that if lung cancer is detected and treated early, 88 percent of patients could expect to live 10 years or more.<br><br>"We have the technologies, and the words 'lung cancer' and 'cured' do go together in a sentence," he said.<br><br>Joyce Neifert, co-chair of Lung Cancer Alliance -- California, followed up Jablons' remarks by seconding, "With screening, we finally have something to talk about."<br><br>For <a href="people/jahan_thierry.php">Thierry Jahan, MD</a>, associate clinical professor of medicine, treating lung cancer patients is no longer palliative care. "We're in an era where treating patients with lung cancer is beneficial for their survival and their quality of life," he said. "We're getting closer to the days when we are not using the harsh drugs. We have drugs today that are now effective and not toxic."<br><br>(Note that in November 2007 the UCSF Comprehensive Cancer Center was renamed the UCSF Helen Diller Family Comprehensive Cancer Center.) 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2006/12/11/lung-cancer-survivors-find-reason-for-hope.825 /ics/2006/12/11/lung-cancer-survivors-find-reason-for-hope.825/lung-cancer-survivors-find-reason-for-hope.825.ics 825 left 1 1 1549 12/11/2006 2006-12-11 08:43:00 8:43 am PST left 16154 ucsf/news_import.pl 1 1 1 In a room overflowing with people at the UCSF Comprehensive Cancer Center, David Jablons, MD, professor and chief of thoracic surgery, gave the audience, many of whom are patients under his care, a reason to hope. "We are making progress -- there are exciting sciences ... In a room overflowing with people at the UCSF Comprehensive Cancer Center, David Jablons, MD, professor and chief of thoracic surgery, gave the audience, many of whom are patients under his care, a reason to hope."We are making progress -- there are exciting sciences ... 12/11/2006 8:43 am PST US/Pacific Lung Cancer Survivors Find Reason for Hope Lung Cancer Survivors Find Reason for Hope lung-cancer-survivors-find-reason-for-hope.825 /2006/12/11/lung-cancer-survivors-find-reason-for-hope.825 826 2011-12-22 17:17:15.655697-06 public Carol Hyman, UCSF News Services article 1 4 http://ti.ucsf.edu/element/auje3xj/counter/826 2011-12-22 17:17:15-06 http://news.ucsf.edu/releases/cancer-immunoresistance-linked-to-loss-of-tumor-suppressor-gene/ Cancer immunoresistance may be partially due to loss of a well-known tumor suppressor gene, according to new research led by <a href="people/parsa_andrew.php">Andrew T. Parsa, MD, PhD</a>, assistant professor of neurological surgery at the University of California, San Francisco. The findings are reported today (December 10) online and are scheduled to appear in the January issue of Nature Medicine.<br><br>It has been known for a long time that cancer cells have many different ways to avoid the immune system, including the common strategies of hiding proteins that are normally expressed on the cell surface or making proteins that act to suppress immune responses, according to Parsa. Some researchers believe that immunoresistance may contribute to cancer progression and development, he added.<br><br>Over the past four years, Parsa's lab has focused on trying to understand how specific mutations associated with high grade glioma correlate with immunoresistance. Malignant glioma is among the deadliest types of brain cancer for which there currently is no effective treatment. 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2006/12/10/cancer-immunoresistance-linked-to-loss-of-tumor-suppressor-gene.826 /ics/2006/12/10/cancer-immunoresistance-linked-to-loss-of-tumor-suppressor-gene.826/cancer-immunoresistance-linked-to-loss-of-tumor-suppressor-gene.826.ics 826 left 1 1 1550 12/10/2006 2006-12-10 08:41:00 8:41 am PST left 16153 ucsf/news_import.pl 1 1 1 Cancer immunoresistance may be partially due to loss of a well-known tumor suppressor gene, according to new research led by Andrew T. Parsa, MD, PhD, assistant professor of neurological surgery at the University of California, San Francisco. The findings are reported today (December 10) online ... Cancer immunoresistance may be partially due to loss of a well-known tumor suppressor gene, according to new research led by Andrew T. Parsa, MD, PhD, assistant professor of neurological surgery at the University of California, San Francisco. The findings are reported today (December 10) online ... 12/10/2006 8:41 am PST US/Pacific Cancer Immunoresistance Linked to Loss of Tumor Suppressor Gene Cancer Immunoresistance Linked to Loss of Tumor Suppressor Gene cancer-immunoresistance-linked-to-loss-of-tumor-suppressor-gene.826 /2006/12/10/cancer-immunoresistance-linked-to-loss-of-tumor-suppressor-gene.826 827 2011-12-22 17:17:16.69495-06 public Jennifer O'Brien, UCSF Today article 1 4 http://ti.ucsf.edu/element/auje3xj/counter/827 2011-12-22 17:17:16-06 http://" UCSF's <a href="people/blackburn_elizabeth.php">Elizabeth Blackburn, PhD</a>, and Roger Nicoll, MD, have each received a 2006 Peter Gruber Prize, awarded annually to individuals in various disciplines who have made discoveries and contributions that effect fundamental shifts in human knowledge and culture.<br><br>Blackburn received the 2006 Genetics Prize for her pioneering studies of telomeres, the tiny caps of DNA that bind the ends of chromosomes, and of telomerase, the enzyme that controls them. Blackburn's research revealed the fundamental role that telomeres play in normal aging and cancer. The telomerase enzyme is now a therapeutic target for diseases related to aging, as well as cancer.<br><br>Blackburn also was cited for her public advocacy of science. As a member of the President's Council on Bioethics from 2001 to 2004, she was an outspoken opponent of a ban on therapeutic cloning, a technique designed to derive embryonic stem cells for the study and potentially treatment of diseases.<br><br>She remained an advocate of public funding and regulation of this research after dismissal from the council, publishing articles in the journals Public Library of Science Biology (the article was accepted to the journal before her dismissal) and New England Journal of Medicine. She believes she was dismissed from the council because of her stance on the issue. 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2006/12/07/ucsf-scientists-honored-for-pioneering-studies-of-aging-cancer-learning-and-memory.827 /ics/2006/12/07/ucsf-scientists-honored-for-pioneering-studies-of-aging-cancer-learning-and-memory.827/ucsf-scientists-honored-for-pioneering-studies-of-aging-cancer-learning-and-memory.827.ics 827 left 1 1 1551 12/7/2006 2006-12-07 08:39:00 8:39 am PST left 16152 ucsf/news_import.pl 1 1 1 UCSF's Elizabeth Blackburn, PhD, and Roger Nicoll, MD, have each received a 2006 Peter Gruber Prize, awarded annually to individuals in various disciplines who have made discoveries and contributions that effect fundamental shifts in human knowledge and culture. Blackburn received the 2006 Genetics Prize for ... UCSF\'s Elizabeth Blackburn, PhD, and Roger Nicoll, MD, have each received a 2006 Peter Gruber Prize, awarded annually to individuals in various disciplines who have made discoveries and contributions that effect fundamental shifts in human knowledge and culture.Blackburn received the 2006 Genetics Prize for ... 12/7/2006 8:39 am PST US/Pacific UCSF Scientists Honored for Pioneering Studies of Aging, Cancer, Learning and Memory UCSF Scientists Honored for Pioneering Studies of Aging, Cancer, Learning and Memory ucsf-scientists-honored-for-pioneering-studies-of-aging-cancer-learning-and-memory.827 /2006/12/07/ucsf-scientists-honored-for-pioneering-studies-of-aging-cancer-learning-and-memory.827 828 2011-12-22 17:17:17.72128-06 public UCSF Science Cafe article 1 4 http://ti.ucsf.edu/element/auje3xj/counter/828 2011-12-22 17:17:17-06 http://www.ucsf.edu/science-cafe/articles/are-most-lung-cancer-deaths-among-long-term-smokers-preventable-with-afford/ Lung tumors are the leading cancer killer, striking down more than 160,000 Americans each year. A large majority of lung cancer deaths might be prevented by screening exams. At least that's what the principal investigator of a recent, controversial study says. Interim results of the ongoing study - the International Early Lung Cancer Action Program (I-ELCAP) -- were reported on Oct. 26 in the New England Journal of Medicine.<br><br>Claudia Henschke, MD, PhD, at Weill Medical College of Cornell University and her I-ELCAP colleagues suggest that periodic screening of smokers and ex-smokers with an imaging technique called spiral CT -- a high-tech kind of X-ray -- may be as cost-effective in saving lives of those with lung cancer as current mammography screening is in detecting early breast cancer.<br><br>Lung cancer is usually deadly by the time it is diagnosed. But I-ELCAP researchers estimate that 88 percent of I-ELCAP study participants diagnosed with and treated for early-stage lung cancer will survive the disease for 10 years or more. Already, the eight patients diagnosed with early-stage lung cancer during I-ELCAP who were not treated have died.<br><br><a href="people/hiatt_robert.php">Robert A. Hiatt, MD, PhD</a>, is director of population sciences for the UCSF Comprehensive Cancer Center. Hiatt served as deputy director of the Division of Cancer Control and Population Sciences at the National Cancer Institute (NCI) during the time when Henschke made waves with her first major study results on CT screening in 1999, and while the NCI deliberated about whether to expand efforts to evaluate spiral CT for lung cancer screening. The NCI eventually launched a separate randomized, controlled trial, for which patients have been recruited.<br><br><b>Q.</b> Screening by X-ray imaging already has been thoroughly evaluated and adopted for breast cancer screening. Why are these techniques still being evaluated for lung cancer?<br><br><b>A.</b> All cancers are different in terms of their imaging characteristics, and in the sensitivity and specificity of the imaging exam. What we have learned from mammography doesn't translate directly into other types of screening.<br><br>The biological characteristics of the tumors are different. A lung cancer, when imaged at the same size as a breast cancer, may be at a more advanced stage. The breast is an external body organ, and can be looked at more carefully and biopsied more easily than the lung. With conventional X-ray imaging, when you can see lung cancer, it may be too late.<br><br><b>Q.</b> Do the I-ELCAP survival estimates seem valid?<br><br><b>A.</b> As far as they go, yes. The model they used to make estimates seems valid. I'm sure that the amount of time between the identification of the tumor by screening and the survival was accurately calculated in I-ELCAP. It's a well-performed study. But what does it mean? Someone with a persistent cough might be diagnosed with a tumor and die five years later. Alternatively, the same person might have been diagnosed via a screening spiral CT exam two years earlier.<br><br>Even if whatever treatment was given following the earlier diagnosis made no difference -- and the person were to die on the same calendar date in either scenario -- diagnosing the cancer early would add two years to the measure of survival. It would seem like the survival had gone from five years to seven years, but there was no real difference to the patient. This is called lead time bias. It's why a randomized trial is needed, in which a control, or comparison, group does not receive the same intervention.<br><br><b>Q.</b> Similarly, is it valid to conclude that spiral CT screening for lung cancer is as cost-effective as mammography?<br><br><b>A.</b> I think it's premature to say that. In order to assess cost-effectiveness, you have to first assess the effectiveness in preventing death from lung cancer. That cannot be done on the basis of this recently published study. The only way you can do that in an unbiased way is with a randomized, controlled trial.<br><br>Furthermore, they do not account for the fairly large number of people who had benign lesions detected that would have needed biopsies -- and maybe lobectomies -- to really get at the diagnosis. They didn't really go into the morbidity associated with the workup -- and that it is a real cost.<br><br>(Note that in November 2007 the UCSF Comprehensive Cancer Center was renamed the UCSF Helen Diller Family Comprehensive Cancer Center.) 25 2 Custom Import cust ucsf/news_import.pl 2 http://cancer.ucsf.edu/news/2006/12/05/are-most-lung-cancer-deaths-among-long-term-smokers-preventable-with-affordable-screening.828 /ics/2006/12/05/are-most-lung-cancer-deaths-among-long-term-smokers-preventable-with-affordable-screening.828/are-most-lung-cancer-deaths-among-long-term-smokers-preventable-with-affordable-screening.828.ics 828 left 1 1 1552 12/5/2006 2006-12-05 08:35:00 8:35 am PST left 16151 ucsf/news_import.pl 1 1 1 Lung tumors are the leading cancer killer, striking down more than 160,000 Americans each year. A large majority of lung cancer deaths might be prevented by screening exams. At least that's what the principal investigator of a recent, controversial study says. Interim results of the ... Lung tumors are the leading cancer killer, striking down more than 160,000 Americans each year. A large majority of lung cancer deaths might be prevented by screening exams. At least that\'s what the principal investigator of a recent, controversial study says. Interim results of the ... 12/5/2006 8:35 am PST US/Pacific Are Most Lung Cancer Deaths Among Long-Term Smokers Preventable with Affordable Screening? Are Most Lung Cancer Deaths Among Long-Term Smokers Preventable with Affordable Screening? are-most-lung-cancer-deaths-among-long-term-smokers-preventable-with-affordable-screening.828 /2006/12/05/are-most-lung-cancer-deaths-among-long-term-smokers-preventable-with-affordable-screening.828


text:
The Old Byre
From $665 / week
Description from the manager
- Cottage
- 1 bathrooms
- Sleeps 4
Bedrooms: -1
Bathrooms: 1
Sleeps: 4
Type: CottageThe Old Byre
Description from the manager
With open views to the surrounding Highlands of Scotland, the cottage is set within enchanting grounds.
Follow the path at the end of the garden and you will find yourself on the Speyside Way; a 50 mile footpath that leads from the Moray Firth, with its beautiful beaches and fishing villages, through to the stunning Grampian Mountains and on towards the Cairngorms.
Situated in Scotland near Aberlour, known locally as "The Jewel of Speyside", The Old Byre holiday cottage is in the heart of Malt Whisky country, indeed the world famous Malt Whisky Trail weaves right past the door.
The Cairngorm National Park is only five miles to the ...Read more
About the manager
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Gael Holiday Homes
Gael Holiday Homes
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Overall rating4.7 / 5.0 based on 134 reviews and 35 properties

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Job Outlook for a CSI Professional
Learn about the education and preparation needed to become a CSI professional. Get a quick view of the requirements as well as details about degree programs, job duties and hands-on training to find out if this is the career for you.
Essential Information
Commonly known as crime scene investigation (CSI) or forensic science technicians, CSI professionals analyze crime scenes and process evidence. Some duties may include taking pictures of evidence, recording information about the crime scene location and preserving evidence that they find. Employers typically prefer CSI professionals who have completed a bachelor's degree related to forensic science and have obtained some hands-on training during the program. Prior work experience also can be helpful in securing a job.
|Required Education
|Bachelor's degree related to forensic science
|Other Requirements
|Hands-on training and experience
|Projected Job Growth (2012-2022)*
|6% for all forensic science technicians
|Mean Salary (2013)*
|$57,340 annually for all forensic science technicians
Source: *U.S. Bureau of Labor Statistics
Employment Outlook for CSI Professionals
According to May 2013 U.S. Bureau of Labor Statistics (BLS) figures, forensic science technicians held approximately 13,430 U.S. jobs, most of which were with local or state governmental agencies (www.bls.gov). The BLS predicted a 6% jump in forensic science technician positions between 2012 and 2022, since forensic science techniques were expected to be used more frequently in the investigation and prevention of crimes. It was anticipated that those who had completed an education program or have work experience would find the best job opportunities.
Education Options for Aspiring CSI Professionals
According to the BLS, employers generally prefer CSI job candidates who hold a bachelor's degree in forensic science or a related field. Students can begin preparing for this career in high school by taking numerous courses in science and math. They also might benefit from classes in chemistry and physics.
On the postsecondary level, prospective CSI professionals might choose to earn a 2-year associate's degree at a technical school or community college and then transfer to a bachelor's program, which usually can be completed in an additional two years. Students also might choose to enroll in a 4-year bachelor's program straight out of high school. Either way, they should choose a program that offers extensive opportunities for hands-on training, which typically is valued by employers. Aspiring crime scene investigators also might opt to specialize in an area like weapons inspection or DNA testing.
In addition to having a formal education, an aspiring CSI professional should possess strong communication skills, be able to work well with others and have expertise in computers. He or she also should be highly organized and demonstrate attention to detail.
Salary for CSI Professionals
Forensic science technicians earned a mean annual salary of $57,340 as of May 2013, according to the BLS. The highest average salary was reported for forensic science technicians working with the executive branch of the federal government, followed by those employed with scientific research and development services.
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Baux18 - Today, 01:49 AM
but compared to antonious were both newbs soooo yea And now I feel old. Thanks, ya jerk. not old! just....err... experienced! yea thats it. and hey the op could be...
Real world bore to paint advice!
foxx0440 - Today, 01:02 AM
So.. Punkworks dudes' (Gordon & Brice,) work is eighter not familiar to the OP or.. He just dismisses it because some how, he has a better way to test what works better in terms of paintball accuracy
Monster Spin Barrel
Youngredbeard8 - Yesterday, 11:05 PM
Hey guys! I've seen several videos regarding the Apex 2 barrel and the flatline barrel together creating this massive spin. The only marker I've seen this done on was a Tippmann A5. This is pr...
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Gtrman8182 - Yesterday, 10:47 PM
Do you like poppet markers or spools - have you had enough experience to know your preference? Both markers are manufactured by Planet Eclipse, and therefore are going to have equally great c...
Need a stock for my X7 Phenom!
Youngredbeard8 - Yesterday, 10:13 PM
What do you know that's cheap about it? Is it more suseptable to breaking/cracking?
Real world bore to paint advice!
Lyxtwing - Yesterday, 09:40 PM
Euphoria, you are incorrect about your underbore and overbore assumptions. Having a close paint to barrel match actually will give you less consistency over either of the other options....
Planet eclipse vs dye elbow pads for comfort/watch wearibility.
get.lit.up! - Yesterday, 09:05 PM
I like my Eclipse pads better overall, and it will probably fit a watch on it. The dye ones do have a padded half glove on them unlike the Eclipse one which has an unpacked half glove.
Etha vs etek4
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Do you like poppet markers or spools - have you had enough experience to know your preference? Both markers are manufactured by Planet Eclipse, and therefore are going to have equally great c...
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Mt. Lemmon SkyCenterRead MoreA small group of explorers stands beneath an open dome of night sky as pinpricks of starlight glitter against the expanse's dark blues and blacks. Each spot of light even seems to look much clearer from here—likely because the group is standing 9,157 feet above sea level. At the Stewart Observatory inside Mt. Lemmon SkyCenter at the mountain's summit, scientists guide visitors through the use of gear such as a 32-inch Schulman telescope—the state's largest public viewing telescope—to probe the far reaches of space to learn about celestial phenomena and take in magnified images of the universe just above. Days and nights at the center bring a slew of learning experiences to budding astronomers. Accompanied by University of Arizona scientists, Discovery Days lead explorations of topics such as tree rings, hummingbirds, and meteorology, frequently beckoning students into the surrounding outdoors. During nightly SkyNights programming, groups summit Mt. Lemmon for a five-hour evening of dining and stargazing at the observatory. One-on-one time with heavenly bodies comes courtesy of Astronomer Nights, wherein site staffers grant singles or pairs lodging, private access to the Schulman telescope, and the chance to contribute directly to the field upon discovering a supernova, nebula, or handlebar mustache on the man in the moon. Periodically, the scientific team also expounds on specific topics, such as digital celestial imaging, with the public in multiple-day workshops. Each participant builds on the Stewart Observatory's list of achievements since 1970, which include furthering infrared astronomy, surveying the moon for Apollo lunar landings, and searching for near-Earth asteroids.933 North Cherry AvenueTucson, AZ US
Arizona Historical SocietyRead MoreThere's little left in Tucson to suggest that back in the mid-19th-century the city served as the Southwest's hub for highway robbers. But it's a fact that the area hosted a string of stagecoach holdups and served as the starting point for Wyatt Earp's infamous vendetta ride. At the Arizona History Museum, relics stand testament to this harrowed past, including an original Concord stagecoach, not unlike those whose occupants were forced to surrender their valuables to roadside brigands. The museum doesn't only explore infamy, though; it illuminates all the forces that took part in Tucson's transition from Paleo-Indian hunting ground to Spanish colonial outpost to the commercial center it is today. Exhibits cover this vast span of time creatively, including a full-size replica of an underground mine that provides a glimpse into early-20th-century working conditions, hands-on exhibits that recall the day-to-day lives of Native Americans, and archaeology displays that detail the surrounding environment's history over the past 4,000 years.949 E 2nd StTucson, AZ US
Tohono Chul ParkRead MoreTucson's Tohono Chul Park serves wonderfully aromatic teas and more. Can't eat gluten? Avoiding fatty foods? Vegan? No problem — Tohono Chul Park offers plenty of options for you as well. Drinks here are readily available, so you can enjoy a glass of red or try something new. Bring your whole brood to Tohono Chul Park, where families can dig in to tasty and kid-friendly fare together. During the summer months, don't miss out on Tohono Chul Park's outdoor patio seating. Throwing a big party? Count on Tohono Chul Park to provide top-notch catering with the same great dishes you love. Free parking is available right next door. You'll typically spend about $30 per person to dine at Tohono Chul Park, so plan your budget accordingly. The menu at Tohono Chul Park includes breakfast, lunch, and dinner — stop by for your favorite meal.7366 N Paseo Del NorteTucson, AZ US
Flandrau Science Center and PlanetariumRead MoreLocated on the University of Arizona's campus, the Flandrau Science Center and Planetarium opens the eyes of all ages to the scientific wonders of our planet, solar system, and universe. The center houses a mineral collection that dates back to 1892, and now holds more than 26,000 specimens including meteorites and minerals from Arizona, Mexico, and elsewhere in the world. They also feature exhibits such as an exploration of Arizona's Sky Islands—mountains that rise above the desert basins and shelter myriad plants, birds, and animals. Other exhibits include Mars: Up Close and Personal, which features a scale model of the red planet's surface.1601 E University Blvd.Tucson, AZ US
International Wildlife MuseumRead MoreThe International Wildlife Museum is a nonprofit institution that works to support various worldwide conservation efforts. More than 400 living and taxidermy-sustained species, plus illuminating exhibits and habitat re-creations, wow crowds of mammal fans and reptile skeptics alike. Visit the Scaly, Not Slimy! reptile exhibit with a significant other to bask in the romantic aura of the naturally top-hatted debonair tortoise, or pick up a family membership to get a year of unlimited museum access, two complimentary guest passes, and discounts on everything from museum programs to items in the gift shop.4800 W Gates Pass RdTucson, AZ US
Reid Park ZooRead MoreMembership in the Reid Park Zoological Society grants you and your family (two named adults and any children under the age of 18) full access to the zoo for an entire year (open every day except Thanksgiving and Christmas). Being a card-carrying member opens up numerous doors, behind which lie benefit after benefit, and sometimes tigers. From June through August, you'll get early-morning entry to the zoo grounds?a calm, crowd-free time to view feedings and animal care firsthand, as well as a chance to lick and groom one's own fur in peace. The "Zoo & You" newsletter will arrive quarterly in your mailbox, keeping readers up to date on all zoo-related happenings. You'll also receive advance notice, discounts, and VIP entry to all after-hours events. If travel plans are in the cards, use your family membership as a veritable Jedi mind trick to receive discounts of 50% to 100% off at 165 different zoos and aquariums throughout the United States. Concerned number-noshers and pachyderm pals should also note that this membership donation is completely tax deductible, and that a portion of the donation will support the construction of Expedition Tanzania, the new, expanded elephant habitat set to open in the fall of 2011.1100 S Randolph WayTucson, AZ US


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NYPD sends intel officer to Moscow after bombing
Posted: 01/25/2011 - A New York Police Department Detective has arrived in Russia to gather information about a suicide bombing that killed 35 people at a Moscow airport.
Posted: 01/25/2011 - A New York Police Department Detective has arrived in Russia to gather information about a suicide bombing that killed 35 people at a Moscow airport.
Posted: 01/25/2011 - Egyptian police are firing tear gas and beating protesters to clear thousands of people from a central Cairo square after a day of demonstrations against President Hosni Mubarak's nearly 30 years in power.
Posted: 01/24/2011 - Witnesses say they saw a woman throw herself from the 23rd story of a Buenos Aires hotel today -- and survive.
Updated: 01/24/2011 - Russian authorities are saying it was probably a suicide attacker who carried out a deadly bombing at Moscow's busiest airport this afternoon.
Posted: 01/18/2011 - Police in Belarus have fingerprinted a deceased journalist in an increasing crackdown on dissent following presidential elections that were seen as fraudulent.
Updated: 01/18/2011 - The United States Geological Service has reported a major earthquake in a remote area in southwestern Pakistan measuring 7.4 on the Richter Scale.
Posted: 01/18/2011 - It's another blow to Iraq's security efforts, as it tries to show that it can protect itself without foreign help.
Posted: 01/18/2011 - Paraguay's president wants police to "exterminate" the activities of a leftist guerrilla group that claimed responsibility for three bombs in the last week.
Updated: 01/18/2011 - A lawyer for Jean-Claude Duvalier says the former Haitiam dictator is facing accusations of corruption and embezzlement for allegedly pilfering the treasury before his 1986 ouster.
Posted: 01/18/2011 - An official from tiny Luxembourg says the country will invest a large sum in Burkina Faso to help alleviate poverty in the landlocked West African nation.
Posted: 01/18/2011 - Polish investigators say Russian air traffic controllers failed to warn the crew of President Lech Kaczynski's plane that it was off course shortly before it crashed last year.
Posted: 01/18/2011 - Tunisia's day-old government is already down four ministers today.
Posted: 01/17/2011 - Protesters have set themselves on fire in Egypt, Algeria and Mauritania.
Posted: 01/04/2011 - What's an Englishman to do when a pint seems just a tad too much?
Posted: 01/03/2011 - Iran has invited Russia, China, the European Union and its allies among the Arab and developing world to tour its nuclear sites.
Posted: 01/03/2011 - Greece's culture ministry says archaeologists on the island of Crete have discovered what may be evidence of one of the world's earliest sea voyages by humans.
Posted: 01/03/2011 - Yemen's interior ministry says two boats carrying more than 80 African migrants have capsized off the Yemeni coast. Most of the passengers are feared drowned.
Posted: 01/03/2011 - Officials of a project to build a bridge linking the Italian mainland to Sicily say the architect for New York's Ground Zero Skyscraper is working on designs for a complex to be built on the Calabrian side of the span.
Posted: 01/03/2011 - A Puerto Rico man accused of attacking his family with gasoline and a blowtorch has been charged with murder after two of his alleged victims died from their wounds.
Posted: 01/03/2011 - The senior U.S. Marine General in Afghanistan says the leaders of the largest tribe in a Taliban stronghold in the southern Helmand province have pledged to halt insurgent attacks and expel foreign fighters.
Posted: 01/03/2011 - A Russian icebreaker is laboring through howling winds and heavy snow as it tries to reach icebound ships in the Sea of Okhotsk where more than 500 seamen are trapped.
Posted: 01/03/2011 - Egyptian investigators say all but one of the 21 victims of the New Year's attack on a church in Alexandria have been identified.
Posted: 01/03/2011 - Hundreds of villagers in Cambodia have flocked to a wedding ceremony between a 16-foot, 200-pound female python and her slightly smaller snake mate.
Posted: 01/03/2011 - Iran's official IRNA News Agency says eight convicted drug traffickers have been hanged.
Updated: 12/16/2010 - President Barack Obama's expansion of the war in Afghanistan has eroded the power of the al-Qaida terrorists who attacked America in 2001 and the resurgent Taliban militants who gave them cover, according to his own government's review.


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Author(s): Davidson, Carl; Matusz, Steven J.
ISBN 10: 0691125597. See all ISBN's
Publisher: Princeton University Press
This is an eTextbook Learn More
While most standard economic models of international trade assume full employment, Carl Davidson and Steven Matusz have argued over the past two decades that this reliance on full-employment modeling is misleading and ill-equipped to tackle many important trade-related questions. This book brings together the authors' pioneering work in creating models that more accurately reflect the real-world connections between international trade and labor markets.
The material collected here presents the theoretical and empirical foundations of equilibrium unemployment modeling, which the authors and their collaborators developed to give researchers and policymakers a more realistic picture of how international trade affects labor markets, and of how transnational differences in labor markets affect international trade. They address the shortcomings of standard models, describe the empirics that underlie equilibrium unemployment models, and illustrate how these new models can yield vital insights into the relationship between international trade and employment. This volume also includes an indispensable general introduction as well as concise section introductions that put the authors' work in context and reveal the thinking behind their ideas.
Economists are only now realizing just how important these ideas are, making this book essential reading for researchers and students.
All ISBN's for this title:
ISBN 10: 0691125597, ISBN 13: 9780691125596, eISBN 10: 1400832160, eISBN 13: 9781400832163
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Reach Us: Correspondence Address:
SCF - 10-11, MDC, Sector 4, Panchkula - 134 112
SCF - 10-11, MDC, Sector 4, Panchkula - 134 112
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