text:
New Guidelines Recommend Fidaxomicin for All Patients Who Are Suitable for Oral Antibiotic Treatment for Clostridium Difficile Infection PR Newswire CHERTSEY, England, October 29, 2013 CHERTSEY, England, October 29, 2013 /PRNewswire/ -- Clostridium difficile infection (CDI), a potentially fatal disease, has surpassed MRSA as the leading cause of healthcare-acquired infections in hospitals ^[1],[2] The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) has published new guidelines recommending fidaxomicin for all CDI patients suitable for oral antibiotic treatment. Specifically the guidelines recommend fidaxomicin as first line therapy in CDI patients with first recurrence or risk for recurrent disease and in patients with multiple recurrences of CDI. The guidelines also recommend fidaxomicin in patients with severe disease and non-severe CDI. ^[3] CDI is one of the most common causes of antibiotic-associated diarrhoea and severe cases can lead to bowel surgery and even death. ^[4] Hospital patients with CDI are up to three times more likely to die in hospital (or within a month of infection) than those without CDI. ^[5],[6] Recurrence is a major challenge in CDI treatment. 25% of CDI patients suffer a recurrence within one month ^[7],[8],[9] and patients who have already had one recurrence have a 40% risk of a further episode of CDI. ^[10] "One of the biggest challenges to optimal CDI management is recurrence, therefore the significant reduction in disease recurrence by DIFICLIR compared with vancomycin is an important step in reducing the morbidity and mortality associated with CDI," comments Professor Oliver Cornely, University Hospital Cologne, Germany. "I welcome these guidelines and believe implementation of the recommendations will help to improve CDI care and reduce the burden on both patients and healthcare systems." Two large Phase III clinical studies comparing the efficacy and safety of 400mg/day oral fidaxomicin with 500mg/day oral vancomycin showed potential advantages of fidaxomicin over vancomycin, the standard of care. ^[9],[11] Patients were eligible to participate in these trials with a confirmed diagnosis of CDI and included patients who were classified as having severe CDI as well as patients for whom CDI is an especial risk such as those patients who were elderly ^[11] or had concomitant diseases. ^[12],[13],[14] Fidaxomicin significantly reduced the rate of CDI recurrence as compared with vancomycin, with patients treated with fidaxomicin significantly more likely than those receiving vancomycin to experience diarrhoea resolution without recurrence within 30 days of therapy completion. ^[9],[11] Fidaxomicin also met its primary endpoint of clinical cure rate, which was equivalent to that of vancomycin. ^[9],[11] Certain populations are at higher risk of CDI and are particularly vulnerable. CDI can be associated with a mortality rate as high as 14% in elderly patients ^[15] and hospitalised cancer patients treated for CDI experience longer hospital stays. ^[16] Progressive chronic kidney disease is associated with increased time to resolution of diarrhoea, lower cure rates, and higher incidence of recurrence in patients treated for CDI. ^[14] Patients in long term care facilities are particularly at risk and CDI recurrence rates can be as high as 50% over a six-month period when acquired in a long term care facility. ^[17] Mortality rates in intensive care unit patients over the age of 65 years have been reported to be as high as 45%. ^[18] In line with the revised ESCMID treatment guidance document DIFICLIR is recommended for patients who are suitable for oral antibiotic treatment in these vulnerable patient sub-populations. "CDI is potentially fatal and has a major impact on patients' health and quality of life. We hope adherence to these recommendations will lead to better management of CDI and the treatment of recurrence," said Ken Jones, President and CEO of Astellas Pharma Europe Ltd. The previous ESCMID guidance document was issued in 2009 ^[19] and has been widely applied in clinical practice. However, as new CDI treatments have been developed an update of this document was necessary to further improve uniformity of national CDI treatment policies in hospitals across Europe. To produce the updated guidelines, ESCMID and a team of experts from 11 European countries ran a computerised literature search to review randomised and non-randomised trials investigating the effect of an intervention on the clinical outcome of CDI. The revised 2013 guidelines provide an overview of currently available CDI treatment options and evidence-based recommendations on the treatment of CDI. ^[3] A full copy of the 2013 updated guidelines and their recommendations are available from: http://onlinelibrary.wiley.com/doi/10.1111/1469-0691.12418/abstract NOTES FOR EDITORS About CDI CDI is a serious illness resulting from infection of the internal lining of the colon by C. difficile bacteria. The bacteria produce toxins that cause inflammation of the colon, diarrhoea and, in some cases, death. ^[20] Patients typically develop CDI after the use of broad-spectrum antibiotics that disrupt normal gastrointestinal flora, allowing C. difficile bacteria to flourish. ^[20],[21] CDI has an enormous impact on healthcare systems and infected patients can stay in hospital an extra 1-3 weeks ^[22],[23],[24] at an additional cost of up to €14,000, compared with patients without CDI. ^[25] About the update of the ESCMID treatment guidance document for CDI The ESCMID and an international team of experts from 11 European countries developed the revised treatment guidance document with the objectives to provide an overview of currently available CDI treatment options and to develop an evidence-based update of treatment recommendations. Treatment options that were reviewed include: antibiotics, toxin-binding resins and polymers, immunotherapy, probiotics and faecal or bacterial intestinal transplantation. ^[3] About Astellas Pharma Europe Ltd. Astellas Pharma Europe Ltd., located in the UK, is a European subsidiary of Tokyo-based Astellas Pharma Inc. Astellas is a pharmaceutical company dedicated to improving the health of people around the world through the provision of innovative and reliable pharmaceuticals. The organisation is committed to becoming a global company by combining outstanding R&D and marketing capabilities and continuing to grow in the world pharmaceutical market. Astellas Pharma Europe Ltd. is responsible for 21 affiliate offices located across Europe, the Middle East and Africa, an R&D site and three manufacturing plants. The company employs approximately 4,200 staff across these regions. For more information about Astellas Pharma Europe, please visit http://www.astellas.eu . References 1. Health Protection Agency. Quarterly Epidemiological Commentary: Mandatory MRSA, MSSA and E. coli bacteraemia, and C. difficile infection data (up to April-June 2013). 12 September 2013. Available from: http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317139835857 (last accessed 23 October 2013). 2. Meyer E et al . Associations between nosocomial meticillin-resistant Staphylococcus aureus and nosocomial Clostridium difficile -associated diarrhoea in 89 German hospitals. J Hosp Infect 2012;82(3):181-6. 3. Debast SB et al . European Society of Clinical Microbiology and Infectious Diseases (ESCMID): update of the treatment guidance document for Clostridium difficile infection (CDI). Clin Microbiol Infect . doi: 10.1111/1469-0691.12418. 4. Ananthakrishnan AN. Clostridium difficile infection: epidemiology, risk factors and management. Nat Rev Gastroenterol Hepatol . 2011;8:17-26. 5. Oake N, et al . The effect of hospital-acquired Clostridium difficile infection on in-hospital mortality. Arch Intern Med 2010;170:1804-10. 6. Hensgens MP, et al . All-Cause and disease-specific mortality in hospitalized patients with Clostridium difficile infection: a Multicenter Cohort Study. Clin Infect Dis . 2013;56:1108-16. 7. Lowy I, et al . Treatment with Monoclonal Antibodies against Clostridium difficile Toxins. N Engl J Med . 2010;362;3:197-205. 8. Bouza E et al . Presented at 18th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona 2008. Abstract0464. 9. Louie TJ, et al . Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med. 2011;364:422-31. 10. Kelly CP, LaMont JT. Clostridium difficile - more difficult than ever. N Engl J Med . 2008;359(18):1932−1940. 11. Cornely OA et al . Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. Lancet Infect Dis . 2012;12:281-289. 12. Cornely OA et al . Resolution of Clostridium difficile -Associated Diarrhea in Patients With Cancer Treated With Fidaxomicin or Vancomycin. J Clin Onc . 2013;31(19):2493-2499. 13. Mullane KM et al . Efficacy of Fidaxomicin Versus Vancomycin as Therapy for Clostridium difficile Infection in Individuals Taking Concomitant Antibiotics for Other Concurrent Infections. Clin Infect Dis . 2011;53(5):440-447. 14. Mullane KM et al . Renal impairment and clinical outcomes of Clostridium difficile infection in two randomized trials. Am J Nephrol . 2013;38(1):1-11. 15. Loo VG et al . A predominantly clonal multiinstitutional outbreak of Clostridium difficile -associated diarrhea with high morbidity and mortality. N Engl J Med . 2005;353 (23):2442-2449. 16. Campbell R et al . Length of stay and hospital costs among high-risk patients with hospital-origin Clostridium difficile -associated diarrhea. J. Med Econ . 2013;16(3):440-448. 17. Kim JH et al . Clostridium difficile infection in a long-term care facility: hospital-associated illness compared with long-term care-associated illness. Infect Control Hosp Epidemiol . 2011;32(7):656-660. 18. Zilberberg MD et al . Clostridium difficile -associated disease and mortality among the elderly critically ill. Crit Care Med . 2009;37(9):2583-2589. 19. Bauer MP et al . European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI). Clin Microbiol Infect . 2009;15: 1067-1079. 20. Poutanen SM et al . Clostridium difficile -associated diarrhoea in adults. CMAJ . 2004;171:51-8. 21. Kelly CP et al . Clostridium difficile infection. Ann Rev Med . 1998;49:375-390. 22. Vonberg RP, et al . Costs of nosocomial Clostridium difficile -associated diarrhoea. J Hosp Infect . 2008;70:15-20. 23. Wilcox MH, et al . Financial burden of hospital-acquired Clostridium difficile infection. J Hosp Infect . 1996;34:23-30. 24. Dubberke MD, Wertheimer AI. Review of current literature on the economic burden of Clostridium difficile infection. Infect Contr Hosp Epidemiol . 2009; 30(1):57-66. 25. Magalini S, et al . An economic evaluation of Clostridium difficile infection management in an Italian hospital environment. Eur Rev Med Pharmacol Sci 2012;16:2136-41. Contact: For further information please contact: Donna Wright, Ruder Finn, firstname.lastname@example.com, Tel: +44(0)20-7438-3085 ; Mindy Dooa, Astellas Pharma Europe Ltd., email@example.com, Tel: +44(0)1784-419-444
New Guidelines Recommend Fidaxomicin for All Patients Who Are Suitable for Oral Antibiotic Treatment for Clostridium Difficile
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Cagayan Valley eyes No. 4 vs Cignal
UNBEATEN Cagayan Valley shoots for a fourth straight victory and an outright semifinal slot when it tangles with Cignal today in the Super Liga women's volleyball at Philsports Arena.
Relying on a short but very effective lineup, the Lady Rising Suns are slightly favored in their 4 p.m. duel with the HD spikers, who are bidding to end a two-game losing streak.
TMS-Philippine Army tries to solidify its second-running position when it collides with slumping PLDT MyDSL at 6 p.m. while Petron tackles PCSO Bingo Milyonaryo in the 2 p.m. opening match at 2 p.m.
Format for the inaugural season calls for a short, single round-robin eliminations with the top two teams securing automatic slots in semis. The last four will dispute the two other berths in knockout matches that will pit No. 3 against No. 6, and No. 4 against No. 5.
Coach Nestor Pamilar credited Cagayan's early success to the Rising Suns' ability to quickly jell. He also has a surplus of firepower in Shiela Marie Pineda, Analyn Joy Benito, Joy Cases and Sandra Delos Santos and a talented libero in Angelique Dionela and setter Wendy Semana.
The HD Spikers will try to bounce back behind Venus Bernal, Honey Royse Tubino and crowd darling Michelle Datuin.
Maureen Penetrante-Ouano, Stephanie Mercado and collegiate superstar Michelle Gumabao powered the PCSO Puffins to their first win, beating Cignal late Friday.
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Telephone & Addresses
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192.com: Michael Brown
50-54, Aberdare
192.com: Michael Brown
192.com: Michael Brown
18-21, Aberdeen
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41-45, Aberdeen
Network Profiles
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Amazon Wish List of Michael Brown
(books, movies, further products)
Amazon Profile: Michael Brown
I remember taping this of the TV in the mid-eighties, and I am not alone, it seems, in noticing that it's had some significant editing for this DVD set. For example ...
Amazon Profile: Michael Brown
Shake Hands with the Devil In this account of the Rwandan genocide, General Romeo Dallaire vividly reveals to the reader the total failure of the international ...
Amazon Profile: Michael Brown
The map was probaby only beneficial for a motorist the detail for walking tracks is very poor and i found many tracks that had been blocked off and turned into a ...
Yellow Page contacts
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Amazon Wedding List: michael brown and sarah english
in Greenock, INVERCLYDE, United Kingdom
Amazon Wedding List: Dr William Michael Brown and Katy Fawcett
in Bolsover, DERBYSHIRE, United Kingdom
GBR Phoenix Beard makes director level appointment
12.09.2012 [The Business Desk (registration)] - BIRMINGHAM consultancy GBR Phoenix Beard has expanded its building consultancy division with the addition of Michael Brown as a director. Brown joins from Knight Frank where he was head of the building consultancy team in Birmingham for more than
Management & Stakeholders
PAUL MICHAEL BROWN of PL1 1LD - contact details and financial details of ADPS HOLDINGS LIMITED and other associated companies
CHRISTOPHER MICHAEL BROWN of L21 8JT - contact details and financial details of OCEAN BLUE SHIPPING AND MARINE SERVICES LIMITED and other associated companies
Business Profiles
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Xing: Michael Brown
Senior Vice President of Eurasia Operations / London, Vereinigtes Königreich / Established organization that helps individuals throughout the world report corporate corruption globally and assists those individuals in collecting rewards under the U.S.'s Dodd-Frank Reward Program
Xing: Michael Brown
Advertising Sales Director / London, Vereinigtes Königreich / Social and Virtual currency, CPE Video, 80 million European unique's, CPA opportunities, App installs, Ability to drive registrations to games.
Xing: Michael Brown
Recruitment Resourcer / Horley, Vereinigtes Königreich / Edit, Clinical Research, Eastern & Western Europe, Clinical Research Associates - all levels, Study Start-Up - all levels, Full Consultation from Application to Offer
LinkedIn: Michael Brown - United Kingdom | LinkedIn
View Michael Brown's (United Kingdom) professional profile on LinkedIn. LinkedIn is the world's largest business network, helping professionals like Michael ...
Private Homepages
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Michael Brown International Trials Rider
Hide menu. Michael Brown International Trials Rider · About · News · Gallery · Sponsors. Photograph Credit: Trials Central. Photograph Credit: Trials Central.
Senior Management - Foxtons Group
Michael Brown joined Foxtons in September 2002 as Chief Operating Officer of Foxtons and Chief Executive Officer of Alexander Hall. He was appointed as ...
Michael Brown | Pianist, Composer
In March 2011 Michael Brown received the 2011 Lili Boulanger Memorial Fund Award. The Fund aims to give support to âcomposers and other musicians of exceptional talent and promise.â
Michael Brown Associates | Architecture …
Michael Brown Associates | Architecture and Design - Welcome ... building dreams
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Michael Brown - Dominvs Group
Michael Brown. May 21, 2014. / by Dominvs Group · Imtiaz Vali · Patrick Williams. News: October 20, 2014. Dominvs Hospitality successfully acquires key Oxford ...
Prof Michael Brown - School of Physics and Astronomy
... News and events · About us. Prof Michael Brown - personal details. Personal details · Publications · Teaching. Contact details. Role: Professor of Astrophysics.
Michael Brown - RCN
Biographical details for Michael Brown, Council member for Scotland.
SkillUp Washington | Funders Group Leadership and Staff
Michael Brown Co-Chair, SkillUp Washington Executive Committee Before joining The Seattle Foundation as Vice President, Community Leadership, Michael
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Michael Brown collection - University of Reading
Michael Brown (1923-1996) was a landscape architect and urban designer known for his limited use of materials which produced distinctive landscapes.
Professor MICHAEL BROWN - University of Aberdeen
Personal profile of Professor MICHAEL BROWN, Chair in Irish, Scottish and Enlightenment History at the University of Aberdeen.
School of History
Dr Michael Brown MA, PhD, FRHists - Reader Contact Details . E-mail - email@example.com Telephone - +44 (0)1334 462899 Fax - +44 (0)1334 462914
Sectarian divide discussed at first Scottish-Irish Conversation | The ...
14.08.2012 Sectarianism, Politics and the Law will be led by Professor Barbara Fennell and Dr Michael Brown, both of the University of Aberdeen. The event will be chaired by the University's Glucksman Professor of Irish and Scottish ...
Celebrities & Politicians
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Bad news
MICHAEL BROWN Death notices, East England - Find Death notices in...
Death notices in East England for
Michael Brown : Memorial - Announcements
(1st August 2013) MICHAEL BROWN (Mike) 19.07.1961- 02.08.2012 You were taken too soon, we miss you every minute of everyday. We hold ...
Michael Brown : Obituary - Announcements
(27th November 2013) BROWN Michael Our dearly loved brother passed away November 16. God saw you getting weary, the hill to steep to ...
Virgin Money Giving | Fundraising | My first London Marathon
Michael Brown is raising money for Oxfam by taking part in the 2011 Virgin London Marathon. Sponsor them with Virgin Money Giving.
Michael Brown is fundraising for Bury Hospice
JustGiving - the easiest way to fundraise and donate to charity online
Books & Literature
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Streetwise Paris
from Michael Brown, Streetwise Maps, 780250008, Map
The Presence Process: A Journey Into Present Moment Awareness
from Michael Brown, Namaste Publishing Inc., 2010, Paperback
The Wars of Scotland, 1214-1371 (New Edinburgh History of Scotland)
from Michael Brown, Edinburgh University Press, 2004, Paperback
World of Digitals: Die Kraft gelebter Gegenwart (ebook/EPUB)
from Michael Brown (author), 2012, Guidebooks, Spirituality, ISBN: 9783641069193
(1 - 4 from 11
Amazon MP3: Michael Brown's Time Travel
from Michael Brown, MIchael Brown, 2011
Amazon MP3: Schubert | Debussy | Brown
from Michael Brown, CAG Records, 2012
Amazon MP3: Shades Of Brown
from Michael Brown, Non EMI, 2007
Amazon MP3: Shades Of Brown
from Michael Brown, Revolver Records Limited, 2008
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Michael Brown Carpets - Trader Profile: Community and ...
Michael Brown Carpets. 3 Windsor Walk Chesterfield Derbyshire S41 0BQ. 07843 769118. www.michaelbrowncarpets.wix.com/chesterfield.
CPS Statement on Michael Brown - CPS News Brief
05.01.2012 Andrew Penhale from the CPS Central Fraud Group said: "The CPS is pleased to have secured the extradition of Michael Brown from Spain, who was arrested in Madrid on Saturday 21 April, following the issuing of a ...
Councillor Michael Brown - All Saints Ward - Conservative Party -...
Details of Councillor Michael Brown of All Saints Ward - Conservative Party
Councillor Michael Brown
Councillor Michael Brown. General; Election History; Party History; Ward History; Members Interests; Committees; Outside Bodies; Training History; Hospitality & ...
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World of Digitals: Dr Michael Brown
Find all publications of the author here.
Download Roster - Free Trade Agency
Video & Audio
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BlinkX Video: 'Bush knew Katrina effects'
A senior official claims the White House knew the damage Hurricane Katrina would do despite protests it caught them by surprise. Former federal disaster chief Michael Brown told... - 10.02.2006, ITN
BlinkX Video: A serious collision between John Terry and Michael Brown | Chelsea's preparations 2011
A serious collision between John Terry and Michael Brown | Chelsea Vs Portsmouth Chelsea's preparations 2011 | Colombia Vs Peru Goals Gol |Argentina Vs Uruguay GoalGoals | Real... - 16.07.2011, YouTube
Michael Brown Crunchin' Tackle - YouTube
A 2 footed tackle from michael brown on sean davis.
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Video: Michael Brown Tornament 1 25 14
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Google News: Cash boosts in the pipeline for Midhurst and Petworth projects
01.10.2012 [Midhurst and Petworth Observer] - Chairman Michael Brown said the committee had agreed to provide £712.44 towards equipment and facilities at Hampers Green Community Centre, where a new weekly lunch club is being organised. He said the committee also hoped to support Shortcut
Heworth ARFLC's momentum fading away
01.10.2012 [The Press, York] - But by half-time Heworth trailed 16-8, an Elland lead that swelled to 22-8 before Wilson notched a second try from a Mike Welsh pass. Just after the hour Elland again crossed to undo the fine work of Wilson, Welsh, Michael Brown and Chris Varley.
Jet2 launch three new flight routes from Newcastle Airport
01.10.2012 [ChronicleLive] - By Michael Brown · Oct 1 2012. Jet2 Holidays. Adventurous holidaymakers can jet off to some of Europe and North Africa's most magnificent cities after the launch of new, one-off flights from Newcastle from Jet2holidays. Jet2holidays will be winging
Residents rally over Lower Sheering homes proposals
01.10.2012 [Harlow Star] - Speaking at Monday's (September 24) town council meeting, local resident Michael Brown said the threat of 600 new homes had come "completely out of the blue". "It's come as a great shock," he added. "It would have a terrible impact on Sawbridgeworth if
Reports & Statements
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Twitter Posts: Michael Brown (MikeBrown_3045)
13.07.2012 Today has been a pretty solid day in the life of michael brown
Wikiquote Quotes: Michael D. Brown
People were getting homes, jobs - everybody was getting served one way or another.
Forest Murmurs
Blog continues here! Posted by Fr Michael Brown at 8:07 am No comments: · Email ThisBlogThis!Share to TwitterShare to FacebookShare to ...
Red tape doesn't just hold back businesses — it can also prevent access to ...
21.09.2012 [Conservative Home (blog)] - ... Mel Stride MP · Melanchthon · Melissa Crawshay-Williams · Michael Ancram MP · Michael Brown · Michael Bull · Michael Burnett · Michael Crowhurst · Michael Ediae-Ehioze · Michael Fabricant MP · Michael Fallon MP · Michael Gove MP · Michael Johnson
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Saturday team news: Mackail-Smith out
28.09.2012 [Yahoo! Eurosport UK] - The versatile Danny Pugh and midfielder Michael Brown returned to the starting line-up in midweek and will be hoping to retain their places, while teenage striker Dominic Poleon, defender Adam Drury and forwards Luke Varney and Andy Gray are all
Michael Brown - Google Scholar Citations
Michael Brown. Human Factors Research Fellow, Horizon, University of Nottingham. Human Factors. Verified email at nottingham.ac.uk - Homepage · Scholar.
Leeds United: Another star showing from Diouf illuminates the Whites - Gray
01.10.2012 [Yorkshire Evening Post] - The two lads in the centre of midfield, Rodolph Austin and Michael Tonge are doing very well for us at the minute, while Michael Brown has also done very well since he's got back into the side as well. Right now, we're strong right down the middle of
Team news: Cox could feature for Forest
14.09.2012 [Yahoo! Eurosport UK] - ... from international duty with Jamaica, but Paul Green remains sidelined with a knee injury, David Norris is expected to miss out after tearing a thigh muscle in the recent win at Peterborough and a third midfielder, Michael Brown, has yet to feature
Why Tottenham fans shouldn't fear going back to the future
26.09.2012 [FootballFanCast.com] - The dark days of David Pleat and a recruitment plan that encompassed the likes of Gary Doherty and Michael Brown over the years had somewhat scorched Spurs fans' opinions of the director of football structure. Of course, Pleat has always been something
East Fife V Ayr at Bayview Stadium : Match Preview
21.09.2012 [Sport.co.uk] - Chisholm is sweating on the fitness of goalkeeper Michael Brown, who is rated 50/50 due to a calf injury. With back-up Andrew Collier already ruled out, Chishom boss could face a Saturday morning scramble for a keeper. The Methil man said, "Bobby will
RESULTS: September 15-16
17.09.2012 [Bicester Advertiser] - Hedley Toms/Michael Brown Trophy: Rutherford 0, Didcot Casuals 1; Red Lion Islip 0, Oxford Spts & Social Club 8. Premier Div: Barton Utd 2, Kidlington Royals 4; Kings Arms Wheatley 4, Dorchester Utd 4. Ridgeway Cup 1st round: Freeland Yeoman 3
Curwen shines alongside Olympic Stars
14.09.2012 [Lancaster Today] - In a squad of mixed levels, old hands Colin Burgess and Chris Hartley are still around and with James Wannop, Decland Ellwood, Michael Brown and Hamish Crichton bridging the gap betwen young and old, Lancaster have a formidable squad. Also being
Cardiff V Leeds at Cardiff City Stadium : Match Preview
14.09.2012 [Sport.co.uk] - ... from international duty with Jamaica, but Paul Green remains sidelined with a knee injury, David Norris is expected to miss out after tearing a thigh muscle in the recent win at Peterborough and a third midfielder, Michael Brown, has yet to feature
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Elena Urioste violin; Michael Brown piano; Principal Players of Aurora Orchestra; Carducci String Quartet. Mozart. Date: 28 November 2014 - 7:30pm.
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Michael Brown. Biography. Find out more about Shooting». BROWN Michael Photo Australia. Sport: Shooting; Gender: Male. Age: 32; Height: n/a; Weight: n/a.
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A.E. Housman
1 of 4 portraits of A.E. Housman
© estate of Sir William Rothenstein / National Portrait Gallery, London
A.E. Housman
by Sir William Rothenstein
sanguine and black chalk, 1906
15 in. x 10 7/8 in. (381 mm x 276 mm)
Given by Rothenstein Memorial Trust, 1953
Primary Collection
Click on the links below to find out more:
Sitterback to top
- Alfred Edward ('A.E') Housman (1859-1936), Poet and classical scholar. Sitter in 4 portraits.
Artistback to top
- Sir William Rothenstein (1872-1945), Artist and teacher of art. Artist associated with 220 portraits, Sitter in 24 portraits.
Linked publicationsback to top
- Saywell, David; Simon, Jacob, Complete Illustrated Catalogue, 2004, p. 316


text:
RPGs - Everything Else
Which series will be the premier JRPG series in 10 years?
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Which series will be the premier JRPG series in 10 years? - Results (128 votes)
Shin Megami Tensei
21.09% (27 votes)
Dragon Quest
5.47% (7 votes)
Final Fantasy
24.22% (31 votes)
Tales Of
9.38% (12 votes)
20.31% (26 votes)
Paper Mario
0% (0 votes)
Kingdom Hearts
3.13% (4 votes)
Etrian Odyssey
3.13% (4 votes)
Other (Specify)
13.28% (17 votes)
This poll is now closed.
CM Punk is a general in the ring.
How could the answer be anything but Pokemon?
The people born today will be going out to buy Pokemon Brown and Talc in 10 years.
Its a good series, but it has the perfect marketing engine, and while it doesn't evolve that much the staleness isn't an issue when new fans are always pouring in.
Click the sites these contain to donate to charity for free http://www.thenonprofits.com/
Dragon Quest might still be popular in Japan. I dunno about final fantasy, maybe it will still be popular in japan.
I can still see pokemon selling multi millions of copies in each region for every new release. It's also the only BIG rpg franchise I see that will still have worldwide appeal, and is still turn based {I believe that in the next 10 years, FF and DQ will become full blown action rpgs}.
so yeah, pokemon.
Is there seriously anyone who would vote for Etrian Odyssey? That's so random.
"Don't blame me, blame yourself or the RNG."
Yeah, it's popular for a niche franchise......but it will never become huge like DQ, FF, or Pokemon.
They'll still make new games for it, and sell enough copies to make a good profit, but I can't see John Q Average Gamer walking into a store to buy a copy.
A bunch of choices that are getting/already are old and niche franchise?
I pick other.
The Elder Scrolls...
Is what I hope makes it.
IMO, the technology will leap forward enough for a newcomer to blow everybody's mind.
I also think there's also a slight chance that Final Fantasy will reign again, their willingness to at least try shaking things up could work to their advantage.
As far as Pokemon, who knows? It could retain popularity based on nostalgia and appeal to children, but people who were born after it first got popular are getting old now.
I still haven't gotten around to trying it so IDK.
Winners don't lose drugs.
CO, WA...We'll kill marijuana prohibition one state at a time if we must.
Honestly I think 10 years from now JRPGs will have totally reinvented themselves for a modern audience.
Amenonuhoko posted...
A bunch of choices that are getting/already are old and niche franchise?
Elder Scrolls is a WRPG series not a JRPG.
CM Punk is a general in the ring.
Amenonuhoko posted...
A bunch of choices that are getting/already are old and niche franchise?
Do you live in a universe where Germany won WW2, and America is now the United States of Japan?
Cause' that's the only way I can see the elder scrolls being a japanese role playing game franchise.
Dark Souls
I'm not entirely certain if Squaresoft will still be around (or at least as influential) in 10 years' time if they continue as they are, although Enix will most likely survive.


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D.C. set to get taxation with representation.
"D.C. set to get taxation with representation."
"After more than 200 years of paying taxes, fighting in wars and abiding by sometimes arbitrary acts of Congress, Washington, D.C., residents are close to getting their first full-fledged representative in the House of Representatives." The 110th Congress is expected to take up legislation to "increase the voting membership of the House from 435 to 437, giving new vote each to Utah" and D.C. "The 600,000 citizens of the district are still the only residents of a national capital in any democracy in the world without full voting rights."


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...until some nasty old dude on a bike slowly wheeled by me muttering these words, "Mmm, mmm, mmm, sexy, so f___ beautiful. What I wouldn't do to..."
First and foremost, let me tell you that I scanned the entire perimeter to make sure he was talking to moi. Being in my fourth month of pregnancy (basically the stage where you just look like a chubbier version of yourself) "sexy" is about the last word in the English dictionary I'd use to describe myself. When I realized there was no one else near, and that this pervert was indeed speaking to me, I felt a wave of heat rise in my chest and then rush through my entire body. I mentally scanned the small items I held in my hands and decided there was only one I was comfortable losing, dog treats. I grabbed a fistful and hummed them at his head and muttered the words, "F__ you, mother______."
When I relayed the story to Matt later that evening, he laughed (thankfully, for some strange reason, my incredibly zen-without-trying-to-be husband finds my bouts of rage/passion amusing). And when I added, "Had I had a rock in my hand I would have thrown it at his ____ head!" he laughed even more. Because I knew this addition would turn his admiration to worry, I didn't tell him that: as I continued to walk down the sidewalk, I imagined old dude passing by me again, and myself, running full force to knock him off his shitty bike.
Yes, my friends, this is RAGE. Next to jealousy, the least "sexy" of all emotions. Especially if you're a yoga teacher, and expected by your community and colleagues to be a living example of patience and compassion.
So how do I reconcile these feelings and my position? First, I will not give in to the oh-so-tempting excuse that "my hormones are reeking havoc on my body during pregnancy, leading me to say and do irrational things." Why? Because my closest friends would be the first to comment "Bullshit" below this post. They know me well enough to know two things: 1) I am a pretty patient and laid back person, 2) however, when someone pushes one of my few buttons?
And secondly, part of my reconciliation involves simply being honest and sharing my experience. How can teachers inspire current and future yogis if we are constantly hiding our dark sides?
When I went to bed last night, I felt the need to ponder my reaction and my buttons. First, I imagined walking along the same stretch with a few of my closest friends, wondering how they'd react in the same situation. Tory? She'd make a quick comeback that would have me dying of laughter. Raven? She'd roll her eyes and say, "Ugh, disgusting," and continue our conversation. And Cathy? Well, let's just say the guy would already be on the ground and there would be a crowd of people confused as to why some crazy lady just pushed a nice old man off his bike.
Next, I wondered why we would all have such different reactions. After some reflection, I realized that my (over)reaction was much deeper than this particular instance. In fact, if I had to estimate, I'd say my rage is nearly a quarter of a century old, stemming from too many instances when a member of my family made lewd and inappropriate comments in my presence. I never felt comfortable speaking up and sharing how it made me feel; I never felt safe to express my fear, anger and disgust.
During yoga teacher training my instructor, Ana Forrest, pointed out that I was holding unexpressed anger in my body and that I needed to learn how to get rid of it. At first I didn't know what she was talking about, but the fact that her comment irritated me was a clue that she was pretty tuned in and I'd better pay attention.
So I did. And I asked questions, like "why" and how" and she responded with answers like anger isn't always a bad thing, it is also the source of your passion and you just need to learn how to transform it. I listened. And I've watched myself shift from the very seemingly calm on the surface Melissa who buries things in my gut to the, "F__ you, mother___" Melissa. I'm not happy with either of them; what I need is a balance between the two.
Imagine that, in between your index finger and thumb, you are holding a spring that has been pinched tight for twenty five years. The expansion of your two fingers is the only thing that will release the coil...
...now also imagine your body, hunched in a tiny airplane seat for a five hour flight from San Francisco to New York. What is the first thing this coil and your body will do when released from this tension? They will first stretch as far as possible before relaxing to find a more comfortable, sustainable position, somewhere in between the contraction and expansion.
This is the stage I am in right now with my anger. I am stretching beyond my natural comfort zone, I am springing further than the coil needs to be at its resting point. This, I hope, is the first step (at least on my journey) to finding balance.
I offer this up to my readers and yogis who may too be on the same path with anger or some other repressed emotion. I just hope that - for your sake - your unexpressed feelings aren't of the pervy nature, and that you're not riding a bike in my direction.
Photo borrowed from www.123rf.com
PS - Thanks to my other dear friend Marcie for helping me process this experience and for the visuals...for the record, had she been there with me, she'd have just laughed at the old fart.


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Fergie, wet n wild, and Walgreens Present Donation to amfAR Business Wire LOS ANGELES -- December 10, 2013 wet n wild (www.wnwbeauty.com) and their iconic Global Beauty Ambassador, eight-time Grammy award-winning artist, Fergie, had a big reason to celebrate last Thursday night! Together with Walgreens, they made an incredible $50,000 donation to amfAR amidst a plethora of celebrity and industry attendees at an exclusive party held at New York City Meatpacking District hotspot, Tao Downtown. The amazing event was the pop star's first public appearance since welcoming her first child, Axl Jack Duhamel, this past August. Longtime supporter of amfAR, the American foundation for AIDS research, Fergie and wet n wild ^ collaborated this year in curating her Perfect Pout Lip Color in V.I.Pink for the cause. As part of her Fergie CenterStage Collection sold exclusively at Walgreens, the three parties pledged to donate $0.50 from each sale of her lipstick to amfAR. They proudly presented the foundation with a check totaling over $50,000 at the bash. "wet n wild, Walgreens, and I have been working on a ton of projects in the past year, and I couldn't have better partners here tonight to celebrate our latest initiative: our collective support of amfAR, a foundation dedicated to ending the global AIDS epidemic," Fergie said. "It all started with my Walgreens-exclusive cosmetic line. wet n wild and I created my Fergie Perfect Pout Lip Color in V.I.Pink for this cause that's near and dear to me. This partnership has lead to raising tens of thousands of dollars to this most worthy cause. What better reason to party?" "wet n wild and Walgreens are both dedicated to being #1 in beauty and improving lives through philanthropy," said Bill George, President of wet n wild. "wet n wild gives confidence to millions around the world by delivery amazing fashion all women can afford. Walgreens lives it every day in their 'Happy & Healthy' promise that has lead to key strides in HIV/AIDS research. Together, we want to ensure all women, regardless of their economic status, can be as beautiful as they want to be – in mind and body. And we're not stopping here. Our amfAR initiative is just one of many where wet n wild, Fergie, and Walgreens' goals align. It's great to be celebrating what we've achieved, but more importantly, we're most excited for what's on the horizon." "Walgreens has enjoyed collaborating with wet n wild and was thrilled to participate in this initiative to help support the amfAR organization," said Shannon Curtin, group vice president for beauty and personal care at Walgreens. "This collaboration reflected our efforts to build awareness and raise funding to continue research, and help people get, stay and live well." Fergie and wet n wild have been partners since announcing her as the global beauty ambassador in March 2012, and the charitable initiative kicked off with Fergie's appearance on Good Morning America in March earlier this year. Fergie was then honored at the third annual amfAR Inspiration Gala in Brazil in April, during which she received the amfAR Piaget Award of Inspiration. About wet n wild^® For over 30 years, wet n wild has kept its promise to be the trusted beauty destination for women, inclusive of all age, ethnicity, skin color, and economic status. As trendsetters in color and leaders in package design, no other brand delivers a better product for a better price. A division of Markwins Beauty Products located in the heart of Los Angeles, California, wet n wild continues to be the top-selling value brand in North America by balancing accessibility and quality – giving women the confidence and freedom to express themselves. The Fergie CenterStage Collection by wet n wildwas carefully-crafted to cater to women with a diversity of skin tones and preferences to experiment with color. Fergie, the creative force behind the collection's signature fashion-forward yet accessible style, spearheaded the line's inception to deliver luxurious, yet affordable products to her fans. Every item is personally-inspired, hand-selected, tested for performance, and named by Fergie and her creative vision. About Walgreens As the nation's largest drugstore chain with fiscal 2013 sales of $72 billion, Walgreens (www.walgreens.com) vision is to be the first choice in health and daily living for everyone in America, and beyond. Each day, Walgreens provides more than 6 million customers the most convenient, multichannel access to consumer goods and services and trusted, cost-effective pharmacy, health and wellness services and advice in communities across America. Walgreens scope of pharmacy services includes retail, specialty, infusion, medical facility and mail service, along with respiratory services. These services improve health outcomes and lower costs for payers including employers, managed care organizations, health systems, pharmacy benefit managers and the public sector. The company operates 8,131 drugstores in all 50 states, the District of Columbia and Puerto Rico. Take Care Health Systems is a Walgreens subsidiary that is the largest and most comprehensive manager of worksite health and wellness centers and in-store convenient care clinics, with more than 750 locations throughout the country. About amfAR amfAR, The Foundation for AIDS Research, is one of the world's leading nonprofit organizations dedicated to the support of AIDS research, HIV prevention, treatment education, and the advocacy of sound AIDS-related public policy. Since 1985, amfAR has invested more than $366 million in its programs and has awarded grants to more than 2,000 research teams worldwide. Contact: Creative Media Marketing Carolanne Coviello, 212-979-8884 email@example.com
Fergie, wet n wild, and Walgreens Present Donation to amfAR
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A Brown to put up 9.6-MW power plant in South Cotabato
popular .
A BROWN Company Inc. has unveiled plans to build a bunker-fired power plant in South Cotabato in cooperation with the electric cooperative serving the area.
The planned power plant is expected to alleviate the worsening electricity supply shortfall in southern Mindanao.
In a statement, the publicly listed firm said it had signed a memorandum of understanding with South Cotabato II Electric Cooperative Inc. (Socoteco II), paving the way for the installation of a 9.6-megawatt bunker-fired power plant.
Both parties agreed to negotiate within a 90-day period the final terms of the supply, installation and operation of the said bunker-fired power generation plant.
A Brown and Socoteco II said the proposed power project was "timely" because of the critical power situation on the entire island of Mindanao.
The Mindanao power shortage is most acute during daytime when demand is at its peak.
Socoteco II distributes electricity to General Santos City and the provinces of South Cotabato and Sarangani. It is among the cooperatives that are suffering from the power supply deficiency on the island.
Within its franchise areas, Socoteco II has to implement load dropping or rotating blackouts, resulting in large opportunity losses for businesses in the area.
"Both parties also see the urgency of setting up a new power facility as there is no new large generating capacity scheduled to come online in the Mindanao grid in the next three years," A Brown said in the statement.
The deal between the two parties was signed by Socoteco II president Elenito C. Senit and A Brown vice president for business development Roel Z. Castro.
In a meeting on Oct. 20, 2012, the board of Socoteco II passed Resolution No. 53, Series of 2012 to accept A Brown's proposal, subject to review by its technical working group and legal departments, and to the guidelines of the Energy Regulatory Commission.
Socoteco was organized and registered with the National Electrification Administration on May 7, 1977 as the 84th electric cooperative by virtue of Presidential Decree No. 269. Its primary objective is to make electric service available throughout its coverage area in the least costly manner.
A Brown, meanwhile, was established in 1994 with major interests in real estate, infrastructure development, agribusiness and investments in listed companies.
The company, through subsidiary Palm Thermal Consolidated Holdings, is the developer of the 135-MW coal fired power plant project in the province of Iloilo.
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The AccessPortal is architected with isolated VLANs and virtual networking resources that you control from top to bottom. You can even establish a site-to-site VPN to extend your office network into our environment and utilize the cloud resources as if they were sitting in your server closet.
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I have used this and it seems to work better than other flea shampoos
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We have used this product for over a year and it was highly recommended to us. We love it and so does our pup.
Pros: Nice scent, lathers well, not irritating to the eyes
Cons: a little expensive.
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BREAKING: Greenpeace Activists Greet G20 Leaders with Massive Banner on the West End Pittsburgh Bridge
"Road sign" underscores the danger of global warming inaction
PITTSBURGH, Sept. 23 /PRNewswire-USNewswire/ — Greenpeace activists are in the process of rappelling off of Pittsburgh's iconic West End bridge with a massive banner displaying their message to G20 leaders gathering for tomorrow's summit. The banner, nearly 80-feet by 30-feet in size, took the form of a stylized "road sign" that warns of the political maneuvering and delay that have put a international climate treaty in jeopardy as the world enters the final stretch on the road to Copenhagen.
The message comes on the heels of a major address by President Barack Obama on climate change at the UN, where he warned of the tremendous danger the world faces from global warming but failed to commit his country to the science-based action necessary to stop it.
Key to the meeting here is a commitment by wealthy nations to invest at least US$140 billion annually by 2020 in order to help the developing world adjust to unavoidable climate impacts, build a clean energy economy, and preserve tropical forests. In July, President Obama and other leaders tasked G20 finance ministers to work on climate finance and report back on progress at the G20 summit.
"It is imperative that developed world leaders do not fail again in Pittsburgh. They must put money on the table to support developing countries," said Damon Moglen, Greenpeace USA's global warming campaign director. "It is also critical for G20 leaders to agree to kick-start economic recovery through clean energy investment. Both of these elements are vital to achieve a good deal in Copenhagen and avert catastrophic climate change."
Economic recovery is dependent on tackling climate change. If leaders fail to take the actions urgently needed this year, climate impacts will likely cost over 20 percent of global output–more than the Great Depression and both World Wars combined – in addition to the human deaths and species' extinction, according to Lord Nicholas Stern, former World Bank chief economist.
Tackling climate change and investing in energy would be a fraction of this cost, just one or two percent of global GDP. A recent report from Greenpeace and the European Renewable Energy Council shows the renewable power industry could support 8 million jobs by 2030, if governments switched from carbon intensive energy to renewables.
The G20 leaders of developing countries must demonstrate leadership in Pittsburgh, the final time they will meet ahead of the Copenhagen climate summit, and break the deadlock plaguing climate talks by:
- Kick-starting growth by agreeing here and now to develop clean technologies for the future, creating jobs while lowering carbon emissions to keep global temperature rise as far below 2 degrees Celsius as possible.
- President Obama, Chancellor Merkel, President Sarkozy and other industrialized country leaders must take responsibility and send a strong signal that they will put money on the table – at least US$140 billion annually by 2020 – to support clean energy and other mitigation activities, forest protection and adaptation in developing countries.
Photos and video will be available at:
http://usaphoto.greenpeace.org/20090923G20/ and
Follow the action on Twitter at Twitter.com/greenpeaceusa
Banner Message
Danger. Climate Destruction Ahead. Reduce CO2 Emissions Now.
SOURCE Greenpeace


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Whats the song?
This member has provided no bio about themself...
Whats the song?
Badass, simply a badass picture for this mod. Actually this mod looks badass in all senses.
You cant stab people with rocks.
thanks looks pretty good.
Good think Bush isn't president anymore; if we found life on other planets he would think they were in possession of WMD's and invade their planet XD
RETARDS!!! l4d2 will have lots of new features, just watch the previews...
nice :)
wow that l4d mods comeback sucked XD
definately chat, the quickest and easiest to do.
no it doesnt, it works with and without this patch, except its better with this patch
i got a similar issue, so i uninstalled stalker, reinstalled, then patched to the latest version, and THEN installed the stalker complete base, finally i installed the patch, and presto, 80 fps maxed out with no crashed in 40 hours of gameplay (and im running those ****** ati 9.4 hotfix drivers XD)
U CUD UB3R PWN SUM nubs wit dat!
damn it now i have to got to crappy *** filehippo. well there is still gamershell, but its not that great and fileplanet sucks ****. i hope it comes back one day...
its so huge
now thats what i call good music
i agree with headcrab...... SHUT THE **** UP TUBE!!!
HOLY SHITLOADS OF SEXINESS!!! THAT WAS AMAZING! For a sec there i thought it was half life 3 (no joke). cant wait for it and i wonder if it will be better than opposing forces 2.
oh dont worry it wont become a dead mod its been around for awhile
wow that is one great soundtrack, keep up the good work and i think im gonna get the soundtrack
wow cool
this is more realistic than DOD! and the weapons textures are amaaing. btw ive been playing it for a week now, love the parachute drop in
then get it, itll sure be worth it
one more thing, is the engine going to be tweaked for better performance like warhead or are u running an unmoddified engine.
yeah come on guys. this could rival black mesa mod and neotokyo, and could be better. besides it has to be good if i heard about its development as early as december 2007. even the alpha trailer with untextured mechs looked good. this mod looks amazing so could you at the least tell which quarter of the year its coming out in?
incredible skin!! keep up the good work
so bad theres no rating
cool, looks a lot more painful than AA12


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Hard to find in this larger size, a really nice mahogany table top or wall mountable curio display cabinet, this measures a full 23 1/2" tall by 19 1/2" wide by 9" deep, and has a good quality plexi-glass (for weight issues) fronted central cupboard. The interior of the cupboard is fitted with 3 shelves, and there are outer curved sections to each side with matching shelves, it sits on four small turned feet, and has matching top finials that repeat the design,along with an ornate cornice. The cabinet is in good estate order with all the hardware present and working, the finish is in good shape with just slight wear and aging to the color, there is one small shrinkage crack in the interior to the back panel that is surface only and will not show when there are items inside. This is sturdy and nice quality, it would be very useful for displaying a collection of small items, please see the photos as an integral part of the description. This is large and quite heavy, I have marked as freight, I will ship at exact cost which will depend a great deal on the final destination.
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Beautiful Estate Items from South Carolina, plus much more!
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- 02.13.2015Northwestern Anesthesiology dominates January Anesthesia & Analgesia
- 02.10.2015Faculty and CRNA Recruitment
- 01.27.2015Dr. Garcia-Anoveros' study links lysosomal dysfunction with neonatal intestinal disorders
- 01.22.2015Dr. Christine Park to co-chair 2016 International Meeting on Simulation in Healthcare
Our Department
Anesthesiology focuses on minimizing pain and maximizing perioperative comfort for patients in a clinical setting. The Department of Anesthesiology at Northwestern University Feinberg School of Medicine is committed to improving the future of this field through innovative research and the development of future leaders through our educational programs. Our students, residents, and fellows gain exceptional clinical experience through the diverse clinical sites of Northwestern Medicine.
We are currently recruiting full-time faculty and CRNA positions. For more information, see the Annoucements section.
Recent Publications
Pupillary Reflex Dilation to Predict Movement: A Step Forward Toward Real-time Individualized Intravenous Anesthetics.
Larson MD, Gupta DK.
Anesthesiology. 2015 Mar 2. [Epub ahead of print] No abstract available.
Brain white matter abnormalities in female interstitial cystitis/bladder pain syndrome: A MAPP Network neuroimaging study.
Abdominal circumference but not the degree of lumbar flexion affects the accuracy of lumbar interspace identification by Tuffier's line palpation method: an observational study.
Lin N, Li Y, Bebawy JF, Dong J, Hua L.
BMC Anesthesiol. 2015 Jan 21;15(1):9. doi: 10.1186/1471-2253-15-9. eCollection 2015.
Intraventricular hemorrhage: It's the blood that matters, not the timing.
Maas MB.
Neurology. 2015 Feb 6. pii: 10.1212/WNL.0000000000001348. [Epub ahead of print] No abstract available.
A Non-canonical Pathway from Cochlea to Brain Signals Tissue-Damaging Noise.
Flores EN, Duggan A, Madathany T, Hogan AK, Márquez FG, Kumar G, Seal RP, Edwards RH, Liberman MC, García-Añoveros J.
Curr Biol. 2015 Mar 2;25(5):606-12. doi: 10.1016/j.cub.2015.01.009. Epub 2015 Jan 29.
Editorial comment: cardiac arrest from local anesthetic toxicity after a field block and transversus abdominis plane block: a consequence of miscommunication between the anesthesiologist and surgeon and probable local anesthetic systemic toxicity in a postpartum patient with acute Fatty liver of pregnancy after a transversus abdominis plane block.
Wong CA.
A A Case Rep. 2013 Dec 1;1(5):77-8. doi: 10.1097/ACC.0b013e3182a88776. No abstract available.
Editorial Comment: Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine.
Bauchat J.
A A Case Rep. 2014 May 1;2(9):106-7. doi: 10.1213/XAA.0000000000000014. No abstract available.
Transient facial nerve palsy after auriculotemporal nerve block in awake craniotomy patients.
McNicholas E, Bilotta F, Titi L, Chandler J, Rosa G, Koht A.
A A Case Rep. 2014 Feb 15;2(4):40-3. doi: 10.1097/ACC.0b013e3182a8ee71.
Cervical spinal cord stimulation treatment of deafferentation pain from brachial plexus avulsion injury complicated by complex regional pain syndrome.
Chang Chien GC, Candido KD, Saeed K, Knezevic NN.
A A Case Rep. 2014 Aug 1;3(3):29-34. doi: 10.1213/XAA.0000000000000041.
Using Next-generation RNA Sequencing to Examine Ischemic Changes Induced by Cold Blood Cardioplegia on the Human Left Ventricular Myocardium Transcriptome.


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My GO TO…Delay: Three Pros Share Their Secret Weapons
First in a series, where busy producers/mixers/engineers provide tips and techniques on their top studio tools.
When it comes to gear, engineers, producers and musicians are creatures of habit. When I find a piece of gear, or a plug-in with a killer sound that works consistently from project to project, I stick with it.
ItŌĆÖs when IŌĆÖm forced out of my comfort zone by working in an unfamiliar studio environment, or perhaps by an artist or co-producer who has fresh ideas on how to achieve a particular sound that I often do my best work.┬Ā I always love finding new tools and new approaches to sound.
This column is the first in a series of pieces where we will focus on a particular tool for recording and mixing and bring you some tips and tricks on how to make it work in your mixes.
WeŌĆÖll also survey a few engineers and producers to get their unique insight into their favorites and how they like use them!
TodayŌĆÖs feature: Delay.
Delay is one of my favorite effects to work with in mixes because of its sheer versatility.┬Ā Delay can add space and ambience to a dry guitar, accent a word or phrase of a vocal, or even artificially create the effect of a doubled track.
When I first started making my way through the studio ranks, hardware staples like the Lexicon PCM 42, TC 2290 and AMS DMX were in nearly every control room.┬Ā Before my time, tape delay was prominent in the 1950ŌĆÖs and 60ŌĆÖs with artists like Elvis and The Beatles using the actual heads on a tape machine to create a delayed slap back sound.
In the 70ŌĆÖs and 80ŌĆÖs, hardware boxes like the Roland Space Echo were all the rage in studios and used by many classic artists like Pink Floyd and Radiohead.
Gradually, as software effects became more and more ubiquitous with recording, certain plug-ins became the go to for many engineers.┬Ā┬Ā Among the favorites from the last ten years would be Line 6ŌĆÖs Echofarm, Waves Supertap, PSPŌĆÖs 85 and 608 and my go to delay currently: SoundToys EchoBoy.
The reason I like EchoBoy so much is that on any given mix, it can be anything I want it to be.┬Ā Lately, IŌĆÖve been gravitating towards a preset called ŌĆ£HallwayVocalŌĆØ which combines a heavily diffused ŌĆ£splatteredŌĆØ sound with a very short stereo slap.
The resulting sound, when carefully blended, creates a lush stereo presence for my lead vocal without being overly obvious that itŌĆÖs even a delay.
Hear Zach McNees' use of Echoboy "HallwayVocal" preset on the song "Magnolia" by Ali Hoffman, followed by the full mastered version of the track. ┬Ā
So what is everyone else doing with delay these days?┬Ā IŌĆÖve spoken with Engineers Brian Bender, Kevin Killen, and Jason Finkel about some of their favorite delay units and how they like to use them.
GO TO PRO #1: Brian Bender
Brian Bender and I were colleagues at The Hit Factory here in New York prior to its close.┬Ā Since then, Brian has been quite busy at his own facility The Motherbrain in Sunset Park Brooklyn cranking out some of the tastiest records IŌĆÖve ever heard.┬Ā Recent highlights include the last Jose James record ŌĆ£No Beginning, No EndŌĆØ (co-produced with Pino Palladino), Langhorne Slim and the Law, Krystle Warren, Kris Bowers, Takuya Kuroda and Sister Sparrow and the Dirty Birds.
BrianŌĆÖs GO TO delay: The Fulltone Tube Tape Echo.┬Ā For those not familiar, the ŌĆ£TTEŌĆØ as itŌĆÖs commonly referred is essentially a tiny tape machine built just for echo.
Guitar players and engineers alike use the TTE for itŌĆÖs lush, analog sound.┬Ā The TTE is the real thing and Fulltone does not take kindly to their emulating competitors! FulltoneŌĆÖs mission statement for the Tube Tape Echo states:
ŌĆ£There is nothing funnier than the makers of this new wave of digital and chip-based delays claiming to ŌĆśsound like a tape echo.ŌĆÖ One after another they pop out the same old digital and bucket-bridgate delays that supposedly ŌĆ£emulate the warble and tape head saturation of a tape echoŌĆØ ŌĆ"Bull$#^%.ŌĆØ
I thought this was a perfect lead in for Brian Bender whoŌĆÖs nothing if not a zero Bull$#^% kind of guy.
ŌĆ£It's just the fucking best.ŌĆØ Brian says of the TTE. ŌĆ£It sounds amazing and the build quality is amazing. It's super stable, has flexible controls: independent dry/wet volumes, a record trim for tape saturation, a tilt EQ, swell, and wide range of delay times thanks to its moving head, a la an Echoplex, and two tape speeds.
I use it all the time for slap echoes, especially for vocals, drums, and guitar. And, if you've smoked enough weed, it's endless fun times with King Tubby style dub moments. The classic huge forever swell that goes achingly into feedback, weird pitch artifacting from moving the head or changing the speed or even putting something on the pinch roller to get into chorusing/wow flutter territory.
The addition of the EQ option makes it incredibly useful on tons of sources. You can really change the way the delay sits in the mix, forward to back, just by chilling out the midrange a little with the EQ / input saturation. Check out ŌĆ£Hambone" by Heather Christian and the Arbornauts. The end of that tune is me feeding back the whole mix into the TTE and then manually stopping the capstan with my finger in order to get that full stop effect. Endless fun.ŌĆØ
Why are you gravitating towards the TTE and whatŌĆÖs a cool tip or trick you can share with us about it?┬Ā ŌĆ£As I mentioned before, one of the ways in which the TTE gets the most love in my arsenal is as a slap echo.
Set up an aux send off the track you want to slap around, send out to the TTE and back into your mixer or DAW. I almost always make it a parallel send so I have independent controls over the volume and timbre of each. I find that a range of between 80-120 ms puts you right there in classic slap territory.
One thing that most folks don't seem to think of when they think of slap is being subtle with it. I love┬Āto get a happening slap together and just bury it in the mix. This can really widen/mellow big transients in a very useful way as well as offer a vocal process that sounds and impacts as quite dry, just a little special. Or, go total instant karma and crank that mfŌĆÖer and hard pan it. Solid gold Lennon vibes.
Also, very very short slaps, 5-20 MS can be incredibly useful as stereo wideners too if you're getting bored with harmonizer kinds of options.
Another really great delay that I actually reach for almost as much as my TTE is the Massey TD-5. It is similarly flexible and, especially for digital, really has a special thing. If you want that tape echo thing but don't wanna drop the coin on a Fulltone or vintage equivalent, the Massey is a super sick way to get that kind of thing happening.ŌĆØ
Thanks Brian!
GO TO Pro #2: Kevin Killen
Our next Delay enthusiast is Kevin Killen.┬Ā Kevin is a GRAMMY-winning producer/engineer/mixer whose work is known worldwide (see the SonicScoop feature on his work with U2).┬Ā Featured artists include Peter Gabirel, Elvis Costello, U2, Kate Bush, Jewel, Bon Jovi and many more.
Most recently heŌĆÖs worked with Goodby Motel (ŌĆ£IfŌĆØ), Suzanne Vega (ŌĆ£Queen of PentaclesŌĆØ), and Fake Club (ŌĆ£FuckableŌĆØ).
KevinŌĆÖs GO TO delay is a combo pack.┬Ā In hardware land, KevinŌĆÖs picks are the Electrix Mo-Fx, TC 2290 and Eventide 3500.┬Ā In the box, Kevin gravitates towards EchoBoy and Echofarm.
Why are you gravitating towards the Electrix Mo-Fx and what is a good tip or trick you can share with us? ŌĆ£The Mo-Fx is just a brilliant box, which has so much personality. I have yet to find an instrument that does not take to its colorful manipulation. I will often have my favorite hardware delays setup for tracking and will randomly push an instrument through the Mo-Fx , 2290 or Eventide. Sometimes I will use all three in series just to create a new sound and inspire the collective.
The Mo-Fx is especially great on drums for rhythmic delays with distortion – instantaneous hit maker.
The 2290 is wonderful on vocals, keys and of course guitar.
The H3500 presents an endless myriad of patches to alter or enhance a sound, especially when one gets into pitch shifting and resonance control.
I like to record all my effects to tape / DAW. By imposing a unique sound from the rhythm section up, it tends to inform every other part and performance. It is not unusual for me to use little effects while I am mixing.ŌĆØ
GO TO Pro #3: Jason Finkel
Jason Finkel is a Brooklyn Based producer/engineer/mixer.┬Ā Some of his recent work includes Hundred Waters, ARMS, Little Racer, Friend Roulette and The Living Statues.
JasonŌĆÖs GO TO delay? ŌĆ£The conversation for most people starts and ends with Echoboy, it does with me as well.┬Ā Though I also like the TD5 from Massey and the Tel Ray (Avid),ŌĆØ Jason says.
Why are you gravitating towards EchoBoy? ŌĆ£Aside from your normal delay duties, I really have been into using tight slaps with the HF and LF cut pretty high up. I like to give a touch of ripple or edge to a vocal or instrument. I don't think you recognize it as a delay…it gives texture, and the more you blend in the more it thins out the sound, which may be helpful.
Although, you can turn the mix almost all the way to dry and turn up the output and bring back the delay without effecting your dry — which is super cool — I end up just really cranking the thing until I get it to make my vocal pop. I'm also really into automating the plugin, changing the feedback from section to section or muting for vowels etcŌĆ" It's usually not set-it-and-forget-it.ŌĆØ
What is a good tip or trick you can share with us? "I like the studio tape stuff for clear tight delays, the Electro-Harmonix Memory Man flavor for textural non-classic stuff because itŌĆÖs pretty dark. I also like Space Echo or Echoplex for keys or guitars, and sometimes vocals but it will lo-fi up a source quick.
I like a Tel Ray style or super tight slap with LF cut pretty high for bass — I don't like to double up sub or low frequencies. Tel Ray or oil can stuff is cool on drums. Really, IŌĆÖll flip through tons of sounds to get the color to sit well in the mix before I start thinking about EQing the delay."
Thanks Jason!
Don't Delay…Start Delaying
As is the case with many facets of audio production, when it comes to delay, anything goes!┬Ā Get creative with the tools you have access to or branch out and try something new.┬Ā Crank up the input, experiment with filtering, use your delay to color another effect in the chain, or just find a tasty slap and bury into your mix as an invisible sweetener.
Thanks to Brian, Kevin and Jason for their brilliant insights!
Zach McNees is a Brooklyn-based producer/engineer/mixer and live recordist whoŌĆÖs worked with Bj├Črk, Rob Thomas, Julia Nunes, The Gregory Brothers, Pixies, Liars and Alice Cooper. Get in touch with Zach via http://www.zachmcnees.com.


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Nicklaus wants to challenge, not punish, players
DUBLIN, Ohio The morning calm at Muirfield Village was shattered by a sound that was sure to be sweet music to players.
It came from the engine of a lawn mower.
Mowers were thought to be a myth last year at the Memorial. The rough was supposed to be 4 inches, yet it doubled in length by the end of the week, and was particularly punishing around the greens. It felt as though the U.S. Open had arrived two weeks early.
Geoff Ogilvy feared some players would stop coming.
Phil Mickelson showed his displeasure by praising the course of every tournament he had played that year except for the Memorial. Even before his wife was diagnosed with breast cancer, Lefty did not have Muirfield Village on his schedule this year.
"We were over the top last year," said Slugger White, the PGA Tour official in charge of setting up the course.
The fault fell to Jack Nicklaus – at least that's the perception of most players.
After all, this is the course Jack built for a tournament he has hosted since 1976. Nicklaus built his career around the majors, and he wants the Memorial to be the next best thing.
But even Nicklaus was troubled by the high grass, not to mention the complaints.
"The one thing I never liked as a golfer was hack-out rough," Nicklaus said Tuesday. "I've always felt that if you put the ball in the rough, there should be some chance of playing a shot to reach the green, but not be able to control the ball like you would normally. I think recovery is a beautiful part of the game."
Muirfield Village is spectacular as ever, but not the same this year. The rough is not as dense, not as high. The wooden rakes that created furrows in the bunkers the last three years have been replaced by standard rakes that leave the sand smooth.
This came not from concession, rather discussion.
Nicklaus met with PGA Tour officials, as always, after Kenny Perry won last year with the highest winning score (280) in 23 years.
"I don't think Mr. Nicklaus or the tour liked what came out of last year," said Steve Rintoul, the tour official who oversaw the course setup this year. "The rules committee, in conjunction with Jack, thought it better to have shorter rough."
Ultimately, the tour has the final word in how the course plays.
But if Nicklaus is the one taking the heat whenever someone complains – a chief hobby for most players on this tour – then why not just take full authority of his golf tournament?
Nicklaus chuckled at the suggestion.
"We are part of the tour," he said. "What I want to do is cooperate the best I can, have middle round on what I want to do and what the players like. My feeling is, do I want them to not like it? Of course not. I want everybody to be happy, everybody to enjoy it. But not everyone thinks the way I think. I'm 69. Guys are 40 years younger than I am, or more. They haven't been brought up the way I was.


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corleone »
Khalil McGill – Work Ft. Corleone (Prod. by Reez)
#TKMS2 mixtape releases September 30thRead More »
Corleone – Wayne Flo' (Prod. by Reez)
Space High Corleone releases a new track titled "Wayne Flo" produced by ReezRead More »
Ceezy Corleone (@spacehighceezy) – Gusto (Prod by @Reezshp) (Video)
Here is Ceezy Corleone "Gusto" video which is a preview for his upcoming mixtape. The song was produced by Space High Reez and the video was shot by Space High Reez as wellRead More »


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Ministers cool over drinks ban on public transportTony Blair's ministers distanced themselves yesterday from a scheme to prevent passengers drinking alcohol on trains, buses and planes after police, train companies and rival politicians poured scorn on the proposal.
Blunkett's legal bill and a £15,000 investment· Minister admits buying shares in DNA firm
· Backing from No 10 as Tories call for resignation
National news p4
Art manual inspired me to create Singing Butler, Vettriano admitsThe artist Jack Vettriano has defended himself against accusations that he copied his most famous painting from an art manual.
Five killed in crash after friend's funeral· Two of victims in stolen car had attended service
· Police watchdog to investigate accident.
LVF disbands after loyalists declare truceThe Loyalist Volunteer Force, one of the most reviled and unpredictable paramilitary groups thrown up by the Northern Ireland Troubles, last night ordered its military units to stand down.
Row over pumpkin circumstanceA charity pumpkin growing competition which has been held between two villages for 30 years has been scrapped following allegations of cheating.
National news p5
Blow for BBC as Gervais sets his sights on the big screen
Ricky Gervais, the man behind two of the corporation's most popular comedy characters of recent years - boss from hell David Brent and struggling extra Andy Millman - has revealed that his next project will be a feature film. By Owen Gibson.
Nurses launch legal fight to halt health contracts planLeaders of the nursing profession will launch legal action against the health secretary, Patricia Hewitt, today to try to make her rethink plans to "privatise" local health services.
National news p6
Damien Hirst reigns supreme in art world· First Briton to top ranking of dealers and collectors
· Artist has more clout than Tate director, list says
Youths kill dog by tying it to fireworkA miniature Yorkshire terrier was tied to a firework and blown to bits by three youths who went on to take photographs of its remains on their mobile phones.
National news p7
Are city academies really helping the poorest children?· Government insists there is no cherry-picking
· Report warns of two-tier system based on class
National news p8
Railways to get trial run of airport-style scannersPlans for airport-style security scanners at railway stations with armed police scrutinising passengers are being drawn up to try to stop terrorist attacks on the rail network, the Guardian has learned.
National news p9
Genes of foetus can improve mother's healthThe health of pregnant women can be influenced by the genes of their unborn babies, say Belgian scientists.
Right to roam extends to 7% of EnglandFrom today, walkers will be able to enjoy 2.3m acres (935,000 hectares) of mountains, moors, heaths, downs and registered common land as historic access rights come into force.
World-class computer centre destroyed by fire
A fire destroyed research and equipment worth more than £25m at one of the world's leading computer and electronics centres at Southampton University's Highfield campus yesterday.
£500,000 bill rung up on FO phone lost in IraqA satellite telephone belonging to the Foreign Office disappeared in Baghdad and was not reported missing until a bill of reportedly almost £500,000 had been rung up.
Mixed-ability classes just as effective, study findsGovernment plans to teach more pupils in ability-based sets will not improve performance, according to a report commissioned by the Department for Education and Skills.
Labour MPs question cost of replacing TridentThe extent of support among Labour MPs for the government's plan to replace the Trident strategic nuclear weapons system will be tested for the first time today at a meeting of the parliamentary Labour party.
National news p10
Sex and the supernaturalGothic exhibition at Tate Britain to explore the sensual and the monstrous.
National news p11
WI asked for views in survey on disposal of nuclear wasteSome members have stripped naked for a charity calendar but now the Women's Institute has been charged with addressing a more serious matter: how to handle thousands of tons of radioactive nuclear waste.
Mental health law reforms unworkable, warn advisersGovernment plans to reform mental health law have been thrown into turmoil by an official advisory group's warning that the measures are unworkable without extra resources.
National news p12
As Cameron surges ahead, Boris Johnson adds his supportBoris Johnson, the Tories' best-known backbench character, used an appearance on Radio 4's Desert Island Discs to let it be known he is preparing to give up his part-time editorship of the Spectator to help his Etonian chum David Cameron on the frontbench. By Michael White.
National news p13
Human rights in perilMarcel Berlins: The Human Rights Act - hit or miss? It celebrated its fifth birthday this month and last week I took part in a conference at which human rights experts attempted to answer the question.
ID cards bill faces tough time in Lords after battering from critics· Widespread concern over intrusion and safeguards
· Personal details database said to violate privacy


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Amber & Ann thank you for helping me get stronger. I wonÔÇÖt forget you. ...
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Barcelona coach Tito Vilanova is ready to keep hold of striker Cristian Tello.
Tello is a £7 million target for Liverpool and Valencia.
But Vilanova has decided he wants to keep the youngster and will urge the board to extend Tello's current deal, which expires in 2013.
Football Is Life
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Amy Adams is an experienced transactional attorney. She has the skills to make sure your case is evaluated, prepared, and executed by an experienced professional. From elder law, estate planning and wealth preservation, to complex real estate transactions, her knowledge and experience will take the pressure off you and your family and help you through even the most difficult times. In additional to her practice, she has close ties to title agents and real estate professionals that can held fast track complex real estate transactions.
Serving all of Florida
Our main office is in downtown Orlando. We also have an office in Clearwater Beach and we take cases covering all of Florida including Alachua, Baker, Bay, Bradford, Brevard, Broward, Calhoun, Charlotte, Citrus, Clay, Collier, Columbia, DeSoto, Dixie, Duval, Escambia, Flagler, Franklin, Gadsden, Gilchrist, Glades, Gulf, Hamilton, Hardee, Hendry, Hernando, Highlands, Hillsborough, Holmes, Indian, River, Jackson, Jefferson, Lafayette, Lake, Lee, Leon, Levy, Liberty, Madison, Manatee, Marion, Martin, Miami-Dade, Monroe, Nassau, Okaloosa, Okeechobee, Orange, Osceola, Palm Beach, Pasco, Pinellas, Polk, Putnam, Santa Rosa, Sarasota, Seminole, St. Johns, St. Lucie, Sumter, Suwannee, Taylor, Union, Volusia, Wakulla, Walton & Washington Counties
More about the Adams Law Firm
Established in 2013 The Adams Law Firm is the result of years of experience, first as a criminal prosecutor with the Office of the State Attorney, then as a private attorney at a small boutique law firm where he practiced criminal defense, collections defense, and family law. During this time he gained valuable experience and learned a lot about practicing law. The Adams Law Firm is a result of Josh Adams' determination to increase his access to the clients where he can spend more time fighting for justice. His rule is that his clients have his cell phone number.
Josh Adams is a founding shareholder of The Adams Law Firm. His areas of expertise focuses on Criminal Defense, Civil Litigation, and Garnishment Defense. His experience as a trial lawyer involving many complex cases has resulted in a strong success record.
Josh grew up in Delray Beach, FL. After high school, he enlisted in the U.S. Marine Corps., where served as an infantry rifleman for four years, serving in numerous combat operations and several overseas deployments. After the Marines Josh attended Florida State University, where all four of his siblings attended. After graduating college, Josh attended Florida State University College of Law, earning his J.D. in 2008. Upon graduation, he took a job working for the Office of the State Attorney, where he prosecuted thousands of criminal cases.
He then gained private practice experience before following his dream and starting his own law firm where he fights in the trenches with his clients for the justice they deserve.
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Our Attorneys
Josh Adams
Title: Director
Area of Pracitce: Trial and Litigation, including criminal defense and civil litigation
Husband and Wife Team
Josh and Amy are a husband and wife team. Their experience compliments each other and allows for a diversified and experienced legal team for every case.
Amy Adams
Title: Shareholder
Area of Pratice: Probate, Estate Planning, and Real Estate
Lawyer Joshua Adams
Lawyer Litigation
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Orlando: 33 E. Robinson St. Suite 112, Orlando, FL 32801
Clearwater:235 N. Garden Ave., Clearwater, FL 33755
855-338-0468 firstname.lastname@example.com
Lawyer Joshua Adams
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Lawyer Joshua Adams
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Lawyer Joshua Adams
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