text:
How to check your simple definition of p-value
I just read Andrew Gelman's post about an article with his name on it starting with an inaccurate definition of p-value. I sympathize with all parties. Journalists and editors are just trying to reduce technical terms by presenting layperson definitions. Earlier this year I caught a similar inaccurate definition on a site defining statistical terms for journalists. So admittedly, this wrong definition must be incredibly attractive to our minds for some reason.
A simple rule for testing if your definition is wrong:
- If knowing the truth could make the p-value (as you have defined it) go to zero, then it is wrongly defined.
Let's test:
- wrong definition: p-value is the probability that a result is due to random chance
Suppose we know the truth, that the result is not due to random chance. Then the p-value as defined here should be zero. So this definition is wrong. The Wikipedia definition is too technical. I prefer the one from Gelman's post:
- right definition: "the probability of seeing something at least as extreme as the data, if the model […] were true"
where "model" refers to the boring model (e.g. the coin is balanced, the card guesser is not clairvoyant, the medicine is a sugar pill, etc.). This definition does not fail my test. We can calculate a probability under a model even when we know that model is not true.
R gotchas
I put together a short list of potential R gotchas: unexpected results which might trip up new R users.
For example, if we have a matrix m,
returns a matrix, while
returns a vector, unless one writes
Setting aside what the default behavior of functions should be, my point is simply that these are important to be aware of. https://github.com/mikelove/r-gotchas/blob/master/README.md
Empirical Bayes and the James-Stein rule
Suppose we observe 300 individual estimates which are distributed , with known.
Now if we assume , the James-Stein rule gives an estimator for which dominates .
Below is code for a little RStudio script to see how changing the balance of variance between data y and the variance of the means changes the amount of optimal shrinkage. For more info, read the paper referenced below! It uses the RStudio's manipulate library: info on that.
# Stein's estimation rule and its competitors - an empirical Bayes approach # B Efron, C Morris, Journal of the American Statistical, 1973 n <- 300 sigma.means <- 5 means <- rnorm(n, 0, sigma.means) # sigma.y <- 5 library(manipulate) manipulate({ y <- rnorm(n,means,sigma.y) A <- sum((y/sigma.y)^2)/(n - 2) - 1 B <- 1/(1 + A) eb <- (1 - B) * y par(mfrow=c(2,1),mar=c(5,5,3,1)) plot(means, y, main="y ~ N(mean, sigma.y)\nmean ~ N(0, sigma.mean=5)") points(means, eb, col="red") legend("topleft","James-Stein estimators",col="red",pch=1) s <- seq(from=0,to=1,length=100) par(mar=c(5,5,1,1)) plot(s, sapply(s, function(b) sum((means - (1 - b)*y)^2)), type="l", xlab="possible values for B", ylab="sum squared error") points(B, sum((means - eb)^2),col="red",pch=16) legend("top","James-Stein B",col="red",pch=16) }, sigma.y = slider(1,10))
More hclust madness
Here is a bit of code for making a heatmap, which orders the rows of a matrix such that the first column (as ordered by in the dendrogram) has all 0s then all 1s, then the 2nd column is similarly ordered in two groups conditioning on the 1st column and so on. Hard to explain but easy to see in the picture below. I came up with raising to the power of 2 quickly, but then it took me a few minutes to realize I have to multiply the columns by the order of the order.
x <- replicate(10,sample(0:1,100,TRUE)) library(gplots) hc <- hclust(dist(t(x))) y <- sweep(x,2,2^(ncol(x)-order(hc$order)),"*") z <- x[order(rowSums(y)),] heatmap.2(z, trace="none", key=FALSE, Rowv=FALSE,labRow=FALSE, Colv=as.dendrogram(hc), dendrogram="column", scale="none",col=c("grey","blue"), lwid=c(2,10))
Plot hclust with colored labels
Again I find myself trying to plot a cluster dendrogram with colored labels. With some insight from this post, I came up with the following function:
library(RColorBrewer) # matrix contains genomics-style data where columns are samples # (if otherwise remove the transposition below) # labels is a factor variable going along the columns of matrix plotHclustColors <- function(matrix,labels,...) { colnames(matrix) <- labels d <- dist(t(matrix)) hc <- hclust(d) labelColors <- brewer.pal(nlevels(labels),"Set1") colLab <- function(n) { if (is.leaf(n)) { a <- attributes(n) labCol <- labelColors[which(levels(lab) == a$label)] attr(n, "nodePar") <- c(a$nodePar, lab.col=labCol) } n } clusDendro <- dendrapply(as.dendrogram(hc), colLab) plot(clusDendro,...) }
In action:
Jacob and Monod
The original gene regulation diagram?
J Mol Biol. 1961 Jun;3:318-56.
Genetic regulatory mechanisms in the synthesis of proteins.
Binomial GLM for ratios of read counts
For certain sequencing experiments (e.g. methylation data), one might end up with a ratio of read counts at a certain location satisfying a given property (e.g. 'is methylated') and want to test if this ratio is significantly associated with a given variable, x.
One way to proceed would be a linear regression of ratio ~ x. However the case when 100 reads cover a nucleotide is not statistically equivalent to the case when 2 reads cover a nucleotide. The binomial probabilities will become increasingly spiked at p*n as the number of reads n increases. So the case with 100 reads covering gives us more information than the case with 2 reads covering.
Here is a bit of code for using the glm() function in R with the binomial distribution with weights representing the covering reads.
n <- 100 # random poisson number of observations (reads) reads <- rpois(n,lambda=5) reads # make a N(0,2) predictor variable x x <- rnorm(n,0,2) # x will be negatively correlated with the target variable y beta <- -1 # through a sigmoid curve mapping x*beta to probabilities in [0,1] p <- exp(x*beta)/(1 + exp(x*beta)) # binomial distribution from the number of observations (reads) y <- rbinom(n,prob=p,size=reads) # plot the successes (y) over the total number of trials (reads) # and order the x-axis by the predictor variable x par(mfrow=c(2,1),mar=c(2,4.5,1,1)) o <- order(x) plot(reads[o],type="h",lwd=2,ylab="reads",xlab="",xaxt="n") points(y[o],col="red",type="h",lwd=2) points(reads[o],type="p",pch=20) points(y[o],col="red",type="p",pch=20) par(mar=c(4.5,4.5,0,1)) # more clear to see the relationship # plot just the ratio plot((y/reads)[o],type="h",col="red",ylab="ratio",xlab="rank of x") points((y/reads)[o],type="p",col="red",pch=20) # from help for glm(): # "For a binomial GLM prior weights are used to give # the number of trials when the response is the # proportion of successes" fit <- glm(y/reads ~ x, weights=reads, family=binomial) summary(fit)


text:
30th September 2008
Sean Penn boasts to Madonna about kissing boys 11
1:06 PM — Sean Penn, who is to star in new film Milk, has shared an on-screen kiss with co-star James Franco. The actor was reportedly so excited about his first gay kiss that he sent a text message to Madonna about it.
Gay Congressman at centre of financial crisis 2
12:09 PM — A veteran fighter for gay rights has come under fire for his role in the current crisis in the financial markets.
DeGeneres speaks against Proposition 8 2
11:52 AM — American lesbian comedienne and chat show host Ellen DeGeneres has called for Californians to reject Proposition 8. The amendment to the marriage legislation would effectively ban gay marriage in California, if it passed a public vote in November.
Sydney celebrates first gay Jewish commitment ceremony 2
11:25 AM — The first Australian same-sex commitment ceremony to take place in a synagogue was held on Sunday. Christopher Whitmont-Stein, 38, and Scott Whitmont, 47, had already entered into a civil commitment ceremony in 2002, took part in traditional Jewish wedding rites.
29th September 2008
Indian court told to ignore health minister's call for decriminalisation 1
6:39 PM — A lawyer representing the government of India has said in court that it "does not matter" that the country's health minister supports the decriminalisation of gay sex.
Record turnout at Asia's largest Pride event
6:23 PM — The Taiwanese gay community celebrated the highlight of the 2008 Taipei Gay Carnival with a Pride parade on Saturday.
Greeks protest for same-sex marriage ahead of trial 2
3:26 PM — The case of two same-sex couples who took advantage of a loophole in Greek law and got married on the island of Tilos will be heard by a Greek court later this week.
EU equality summit meets in Paris
3:08 PM — Diplomats, gay rights advocates and representatives from the field of equal opportunities are meeting in France today to discuss how to apply the principles of non-discrimination.
Malawi's gays hope new High Commissioner will help their cause
2:32 PM — The Malawi Gay Rights Movement (Magrim), which was launched earlier this month as a public campaign group after six years underground, has sparked a political row.
Morocco may give gays some rights 'within fifty years' 6
1:49 PM — An international congress on gay rights in Muslim countries has been told that the north African nation of Morocco may grant rights to homosexuals "within fifty years."
Google opposes ban on gay marriage
12:48 PM — Internet company Google will publicly oppose an attempt to ban same-sex marriage in California.
Danish man sought embassy protection after Sarajevo violence
12:00 PM — One of the people injured when a homophobic mob attacked the opening event of Bosnia's first gay festival has spoken of his ordeal.
Pepsi risks boycott with donation to gay support group 6
11:46 AM — A leading soft drinks manufacturer has donated $500,000 (£277,000) to a programme for workplace equality.
26th September 2008
Nations pledge to support gay rights at UN meeting 1
6:23 PM — Several countries have responded positively to recommendations on gay rights at the 8th session of the UN Human Rights Council.
Ugandan activists detained in "pattern of police harassment"
5:34 PM — Two human rights advocates in Uganda were held for a week without charges after police accused them of "recruiting homosexuals."
Indian government argues to retain ban on gay sex 5
3:13 PM — A row between two government departments in India over the decriminalisation of "un-natural" sexual acts has resulted in a victory for those who oppose the change.
Gay Canadians urged to vote Conservatives out of office
2:09 PM — A leading gay and lesbian media group in Canada has published a 16-page expose of the Conservative party alleging that they "pandered to antigay, faith-based groups."
Iranian President attacks US acceptance of homosexuality 11
1:38 PM — The President of Iran has admitted in an interview that there may be "a few" gay people in his country, but attacked homosexuality as destructive to society.
Gay leader assassinated in Baghdad 22
12:43 PM — A leading gay activist in Iraq has been assassinated. 27-year-old Bashar was targeted by gunmen yesterday.
New report shows rise in hate crimes across Europe 2
12:22 PM — A human rights group has published research into incidents of violent hate crime against minority groups in 56 North American and European states.

subset: commoncrawl


text:
'Planning Commission affidavit not to be taken as the last word'
An embarrassed government swung into damage control mode on Wednesday, in response to widespread criticism of an affidavit filed by the Planning Commission that suggested that an individual income of just Rs 25 a day constituted adequate "private expenditure on food, education and health," at a time when even the minimum wage was pegged at over Rs.100 a day, the exact figure differing from State to State.
Sources in the government clarified that the affidavit was not to be taken as the last word on identifying those who would be entitled to food security in the priority sector (those living below the poverty line) and that socio-economic data for 2009-'10 would be studied before any final decision was taken.
Meanwhile, a battle is brewing inside the Planning Commission, with members Mihir Shah and Abhijit Sen taking on the "official line." "Firstly, there is no decision in government yet on how many people will be beneficiaries of any government programme or on how they will be identified," Mr. Shah told The Hindu .
He pointed out that "the socio-economic census, currently underway, will pave the way for deciding which households will automatically be excluded [income tax payees, professionals etc] and which will be included [those without shelter etc]. The rest will be ranked, according to indicators of deprivation and provide the basis for prioritising households for different programmes." To be entitled for food security, he said a person should fulfil two or three prescribed criteria, than an artificial cut-off income.
"There is need to have programme-based lists, creatively using different parts of the data that will be generated by the socio-economic census, which should be completed by the end of the year," Mr. Shah said adding, "We don't need a BPL list."
For instance, he said, the government programmes for housing (the urban or rural poor), for people with disabilities etc., could use different parts of the data base. The data that would emerge from the socio-economic census would be verified in the gram sabhas, so that people would have the opportunity to come up and say whether their personal data was correct or not. The data would also be placed on a website to ensure a "transparent and participatory" process.
Estimates of poverty
Referring to the affidavit, which based its assertions on the Suresh Tendulkar Committee report that pegged the poverty line at Rs. 447 a month (Rs. 15 a day), at 2004-'05 prices, Mr. Shah said: "The Tendulkar report exercise was to create comparable estimates of poverty over a length of time and the impact of government programmes and policy on alleviating poverty. It does not in any way suggest who is entitled to get benefits under the proposed food security programme. The affidavit also suffers from the fact that it does not provide the criteria for who will be entitled to food security benefits, as this was a question that had been posed by the court."
The reason for the "shoddy" affidavit was that it was prepared by "those who have no political stakes," said the government sources, adding that the task of overseeing the drafting of the affidavit was left to a Rajya Sabha member, currently a Minister of State. The sources said the affidavit was symptomatic of major differences within the government on the food security programme, with a powerful section wanting to reduce the numbers.


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Telltale Games is known for their work on the episodic Walking Dead games and The Wolf Among Us, along with recent releases such as Game of Thrones and Tales from The Borderlands. Many of their full titles are available on mobile devices, plus PCs and video game consoles.
The next project in their lineup is a collaboration with Mojang, developers of the insanely popular Minecraft. This project will be called Minecraft: Story Mode, and like Telltale's other offerings, it will feature a complete player-driven narrative experience. It's not a typical Minecraft game, but it should be interesting nonetheless. Read more


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text:
Curiosity Rover's Centaur Stage
August 1, 2012
With a unique view taken from inside Vertical Integration Facility (VIF) at Launch Complex 41 at Cape Canaveral Air Force Station in Florida, an overhead crane lifts the Centaur upper stage for the United Launch Alliance Atlas V. Once in position in the VIF it will be attached to the Atlas V booster stage, already at the pad. The Atlas V is slated to launch NASA's Mars Science Laboratory (MSL) mission. Image credit: NASA/Jim Grossmann Sept. 21, 2011
Topics: Lockheed Martin, Space technology, Space, Space exploration, Atlas-Centaur, Cape Canaveral Air Force Station Space Launch Complex 41, Expendable launch systems, Atlas V, Mars Science Laboratory, United Launch Alliance, Mercury program, Boeing, Centaur, Atlas, Cape Canaveral Air Force Station, Unmanned spacecraft, Technology Internet


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2nd birthday!!!!!
Happily married 6/16/12
Gracie 3/19/11
Colten 11/6/13
Send me a message to know more about Young Living Essential Oils!!
First time single mom to: Boogie Bear
One Canine: Stinky
Four outdoor Felines: Callie, Fuzzie, Doofus
Adorable Monsters is our theme! Family and close friends. Not a ton of people 10-15 probably. I haven't decided what to serve yet, but I have been pinteresting up a storm! I totally dig this stuff.
Steph (31) and Paul (36) married since 10/27/07
Madison Nicole - March 11, 2011
Furbaby - Sadie - 5 yr old White Lab
Steph (31) and Paul (36) married since 10/27/07
Madison Nicole - March 11, 2011
Furbaby - Sadie - 5 yr old White Lab
This party will be very low key compared to her 1st b-day!!! Only 1 side of my family (dad's) celebrates them still. But, we celebrate everyone's birthday who's in March. There are 3 people, including Marchie. So, I only get to go all out with DH's family for her. There will be about 20 people at our house.
Amanda-mommy to ^R.J.^ & ^Baby^, rainbow miracle Kayla Jane 10-24-06 & spirit baby Caroline Ann 3-18-11
(o) (o)=13 month BF/EPer--MILK DONOR!!!
I was initally going to have a huge party and had reserved a hall out of state where my family lives. Then DH is pissing and moaning about the money being spent and whatever.
So the theme is Snow White. Location is still undecided.
Crazy Ft working mother of two small children
We will do a party at our new house and it will be Sesame Place. Food will include mostly finger food and maybe some BBQ- we'll have a bounce house in teh back yard (we live in Orlando so March is a great time of year to be outside!). We'll do someSesame St theme foods- cookie monster cookies- Abbey's fairy fruit wands, Sesame St Chicken, and whatever else I can think of taht would seem like I'm in the least bit creatice. Invites include immediate family, local friends and a few neighbors- we tend to always invite everyone to everything so I'm expecting like 30 ppl or so! Yowza!!
Squeezed a lifetime of love into 1 hour with Tyler on 11/26/09 (CTT with BRA, Potter's Syndrome)
Keira Brielle arrived March '11
@SMKadingo, we too are planning a Mickey Mouse Clubhouse themed party. My dilemna, however, is Minnie Mouse. I prefer the old Minnie in a red dress, but the new Minnie is dressed in pink. What ever shall I do??? LOL I love your ideas for food. I may steal it : )
We will have it at our home and outside, weather permitting. Last year we had about 45 guests, I'm expecting the same for this year.
I'm having a cute Minnie dress made for her, just have to decide red or pink? I'm planning to make every table themed as a different character. So Mickey's table will be red and black with a Mickey centerpiece, Goofy's table will be blue and orange with a Goofy centerpiece etc. I have so many ideas, I just hope it turns out as nicely as I see it in my mind!!!
Busy working Momma to Steven (14), Sarah (10) and our suprise baby, Sofia (3)


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Fiji Time: 2:34 AM on Saturday 23 May
/ Front page / News
By SITERI SAUVAKACOLO
Tuesday, September 02, 2014
+ Enlarge this image
Families, relatives and friends lineup to light the 45 candles for the soldiers detained in Golan Heights during a prayer vigil at the Centenary Church, Suva. Picture: JONACANI LALAKOBAU
Update: 4:06PM THE Centenary Church came to a standstill at midday as only sounds of cries could be heard from family members of the 45 Fijian soldiers held hostage by Syrian militants.
More than
500 people turned up for the prayer vigil led by the president Reverend Tevita
The 45
candles were lit by wives, children and family members of the soldiers.
general secretary Reverend Epineri Vakadewavosa reminded them that God is their
source of strength and their shelter in times of need.
Use the free Acrobat Reader to view.
Copyright © 2014, Fiji Times Limited. All Rights Reserved.


text:
Property Details
Townhome, 3 Bedrooms, 3 Baths, 8 Sleeps
Legacy Villas is a luxurious and beautifully gated community tucked below the Santa Rosa Mountains. This community was built recently in 2007 to originally be apart of the established and world-famous La Quinta Resort & Club however it has now developed into privately owned condominiums and town homes. Legacy Villas is guard gated with a 11,000 sq ft clubhouse, state of the art fitness center, pools located throughout the property, BBQs, outdoor fireplaces, and poolside cabanas. It is a short walk to the La Quinta Resort & Club that offers golfing, tennis, shopping and eating amenities.
This three bedroom town home was designed to accommodate up to 8 people in the unit comfortably. Throughout the home, there are 10 foot ceilings and a lot of windows to brighten your home with desert sunlight. The chef ready kitchen has all new Kohler and Kitchenaid appliances such as: refrigerator, dishwasher, stove, coffee maker, microwave. As well as being full equipped with utensils, cooking pans/pots, kitchen towels, and dine ware. All counter tops are granite to add that extra touch of luxury. You may have your guests enjoy the chef's time at the kitchen bar or at the formal dining table. Each TV has premium channels to watch as well as free wireless internet. Located off the dining/living room is an enclosed patio with patio furniture.
The bedrooms are all upgraded as well with granite counter top bathrooms, separated baths and showers, a lot of cabinet space and large mirrors. There are convenient bars situated in each of the rooms with a refrigerator, coffee maker and sink. Some rooms have a gas fireplace while others have their own desk. Usually each room will have their own private patio with patio furniture. Each room has plenty of luxurious linens, towels, and beach towels for your stay. If these get dirty or you would like to wash some of your clothes, there is a convenient washer and dryer located in the property.
If this three bedroom doesn't sound like it fits your needs please see our other accommodations in the Legacy Villas community or near by resorts in the Palm Springs Area.
Legacy Villas
3 bedroom, 4 bathroom town homes
3 bedroom, 3 bathroom villas
2 bedroom, 2 bathroom villas
Please ask one of our booking agents if you have special needs and/or accommodations, we are more than happy to make adjustments for your vacation. For discounts, special situations or off season rates please contact us.
About the Owner
0 Reviews
Be the first to review this listing!
Activity and Interests
* Legacy Villas are located in the heart of the action and 19 miles
from Palm Springs Airport 2 Hours from LAX & 1 Hour from OC.
* Golf, Tennis, Nature and Mountain Trails,
Shopping, Restaurants and Entertainment.
Tennis,Golf,Spa and Gym,Bike Riding,Horse Riding,
Swimming,Hot Air Baloon,Polo,Desert Adventures,Shopping,Movies,Casinos.
Rental rates
- Nightly Rate: $200 - $700
Weekly Rate: $1200 - $2000
Monthly Rate: $3200 - $6000
Rates Depend On STAY Periods & PEAK Periods and Bedroom Count
June 1- December19, 2011
$125-200 per night (varies with number of bedrooms)
$900-1500 per week
$2700-4500 per month
December 20- April 30, 2012
$200-$400 Per Night
$1200-$2000 Per Week
$4000-$6000 Per Month
Rental Summer Special!,$130 night 2 Night Min
Cleaning Fee,Bed Tax & Security Deposit is Required
We accept Credit Cards, Checks, or Wired Funds.
Reservation must be prepaid,and are non-refundable.
Rates are subject to change at any time. Villa is a no smoking rental Pets are allowed with certain properties.
Call or E Mail if you have any questions.
- 12
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- 12
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Property Type
- townhome
- Adventure
- Budget
- Family
- Luxury
- Romantic
- Spa
- Sports & Activities
Pool / Spa
- Hot Tub
- Outdoor Pool
- pets considered
Sports & Adventure Activities
- golf
- 3 Bathrooms
- Bathroom 1
- Bathroom 2
- Bathroom 3
- 3 Bedrooms, Sleeps 8
- Bedroom 1
- Bedroom 2
- Bedroom 3
- * Legacy Villas amenities include: 2 or 3 Bed Villas or 3 Bedroom Townhouses 2,3 or 4 bathrooms.,1 King Bed, 2 Queen * Beds and 1 Queen Sleeper Couch,1300-2000 Sq Ft, Living & Dining Area, * Full Luxury Kitchen,Washer/Dryer,Mini Refrigerators in each room and coffee maker in Villa Bedrooms. All villa rooms have new TV/DVD, Mini-Fridge, Safe in all Closets, Iron and * Ironing Board,Luggage Valet and extra Blankets and Pillows,Hair Blow Dryer in each Bathroom.Kitchens stocked with Pots and Pans, Utensils, Microwave, Toaster, Blender and Coffee-Maker. Legacy Villa rooms have lock-off capability if vacationing with friends. Truly luxurious and turnkey furnished. * Pools,Spas,Golf,Barbeques,Work Out Gym,Meeting or Party Room,Golf,Tennis,Cabanas,Hammocks,Day Spa,Restaraunts,Shops all within the Community.Also Old Town La Quinta Shopping & Eating Places/Wine Bar.


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Higher frequency of cagA EPIYA-C Phosphorylation Sites in H. pylori strains from first-degree relatives of gastric cancer patients
1 Clinical Research Unity – Department of Internal Medicine, University Hospital Walter Cantídio – Federal University of Ceará, P.O. Box: 60430270, Fortaleza, Ceará, Brazil
2 Laboratory of Research in Bacteriology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
3 Center for Global Health, University of Virginia, Charlottesville, VA, USA
4 Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil
BMC Gastroenterology 2012, 12:107 doi:10.1186/1471-230X-12-107Published: 14 August 2012
To evaluate the prevalence of more virulent H. pylori genotypes in relatives of gastric cancer patients and in patients without family histories of gastric cancer.
We evaluated prospectively the prevalence of the infection by more virulent H. pylori strains in 60 relatives of gastric cancer patients comparing the results with those obtained from 49 patients without family histories of gastric cancer. H. pylori status was determined by the urease test, histology and presence of H. pylori ureA. The cytotoxin associated gene (cagA), the cagA-EPIYA and vacuolating cytotoxin gene (vacA) were typed by PCR and the cagA EPIYA typing was confirmed by sequencing.
The gastric cancer relatives were significant and independently more frequently colonized by H. pylori strains with higher numbers of CagA-EPIYA-C segments (OR = 4.23, 95%CI = 1.53–11.69) and with the most virulent s1m1 vacA genotype (OR = 2.80, 95%CI = 1.04–7.51). Higher numbers of EPIYA-C segments were associated with increased gastric corpus inflammation, foveolar hyperplasia and atrophy. Infection by s1m1 vacA genotype was associated with increased antral and corpus gastritis.
We demonstrated that relatives of gastric cancer patients are more frequently colonized by the most virulent H. pylori cagA and vacA genotypes, which may contribute to increase the risk of gastric cancer.


text: Front Angled view Back Compatible with Marantz Remote app (iPhone not included) Front-panel USB input offers a direct digital connection with your Apple device Full color on-screen guide Marantz Remote app for iPhone Multi-zone control from your smartphone Play different content on 2 TVs with the extra HDMI output Play music from your iPad with AirPlay (iPad not included) Remote Setup Assistant helps you get started View larger Marantz SR6008 7.2-channel home theater receiver with Apple® AirPlay® Item #: 642SR6008 Low Stock 13 Reviews Your price: $899.99 Earn up to 900 Rewards points Add to Cart Free Shipping Lifetime Tech Support + Add to wishlist + Email me alerts for this product View all associated offers Need help? 1.888.955.6000 Email Chat Ask an expert advisor No pressure, no commission — just lots of good advice from our highly trained staff. x By buying this product you'll earn up to 900 Rewards points. When you sign up for a Crutchfield account, you'll be enrolled in Crutchfield Rewards. You'll earn one point for every dollar you spend on gear from us. You can turn your points into Rewards Cards that you can use toward future purchases. You can sign up for an account now, or after you complete your purchase (you'll get credit for the points either way). Sign up for a Crutchfield account


text:
Go Mylo Countdown
Go Mylo Countdown is a Joomla module that counts down from the hosting server's current date/time to a specified date/time using days, hours, minutes and/or seconds. This is one of the most flexible countdown modules for controlling the style and content of your output.
* 24 or 12 - Choose either 24 hour format or 12 hour format.
* Time Zone Offset - If your host server is in a different time zone, the countdown can be adjusted
* Pre and Post Text - Add text above and below the countdown with CSS and HTML tags
* Custom Label, Styling & Location - Add a label to the countdown, use CSS to style it to your liking, position it above, below, to the left, or to the right of the countdown
* Units to Display - Choose the units you wish to display
* Zero Plurality - Toggles usage of plural words when used with the number 0.
* Countdown Styling - Allows the usage of HTML and CSS to style your countdown
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Source Nightclub Tuam
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Tuams longest running and now newly renovated nightclub! 2 bars and a large smoking room catering for over 100 people. Open Saturday nights from 11.30pm with resident djs Graham Doherty & Thomas Carton playing the hottest pop, r&b, hiphop, indie & dance
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text:
A catheter assembly especially adapted for injecting therapeutic liquids such as DNA solutions to a patient's myocardium comprises an elongated guiding catheter for insertion through a patient's artery to the vicinity of the myocardium, a reservoir for therapeutic liquid at the distal end of the guiding catheter, one or more injection needles protruding from the distal end of the guiding catheter and in fluid communication with the reservoir, the extent of needle protrusion being appropriate for penetration of but not passage through the myocardial wall, and an operating device for delivering a predetermined quantity of therapeutic liquid from the reservoir through the needles.
1. A catheter assembly comprising:
an elongated flexible biocompatible tube constituting a guiding catheter and having a proximal end portion and a distal end portion;
a reservoir adapted to contain treatment fluid and disposed in the distal end portion of the guiding catheter;
a guide wire extending through the reservoir to protrude beyond the distal end of the guiding catheter;
at least one needle adapted to protrude from the reservoir and beyond the distal end of the guiding catheter to a predetermined extent;
said at least one needle having a bore with an inlet communicating with the reservoir and an outlet disposed distally beyond the distal end of the guiding catheter;
operating means for delivering a predetermined quantity of treatment fluid from the reservoir through the needle outlet;
and an operating wire extending axially through the guiding catheter from the proximal end thereof to the reservoir, said operating wire connecting the reservoir to the operating means.
2. A catheter assembly of claim 1 wherein said operating means is operable to change the volume of said reservoir so as to expel the contents thereof through said at least one needle in predetermined quantity.
3. The catheter assembly of claim 2 wherein said reservoir comprises a cartridge having a distal end wall carrying said at least one needle and a proximal end wall constituted by a movable plunger connected to said operating means.
4. The catheter assembly of claim 3 wherein said cartridge is movable axially with respect to the guiding catheter in response to operation of the operating means.
5. The catheter assembly of claim 2 including an injection catheter disposed within and axially movable relative to said guiding catheter in response to operation of said operating means, said injection catheter incorporating the reservoir and means for changing the volume of the reservoir.
6. The catheter assembly of claim 5 wherein the reservoir comprises a generally cylindrical chamber having a distal end wall carrying said at least one injection needle, and a proximal end wall movable axially within the chamber in response to operation of the operating means to constitute the means for changing the volume of the reservoir.
7. The catheter assembly of claim 2 including an injection catheter disposed within the guiding catheter, said injection catheter having the reservoir formed therein and defined by deformable side walls, the operating means being operable to compress the reservoir to expel liquid contents thereof through the injection needle.
8. The catheter assembly of claim 7 wherein the operating means comprises a source of fluid pressure applicable to the exterior of the deformable side walls of the reservoir to effect compression thereof.
9. The catheter assembly of claim 1 wherein said operating wire is tubular.
10. The catheter assembly of claim 9 wherein the guide wire extends axially through the tubular operating wire.
11. The catheter assembly of claim 1 including an injection catheter disposed within the guiding catheter, said injection catheter having the reservoir formed therein as a narrow, axially extending lumen, connected at its proximal end to an operating means in the form of a syringe of liquid operable to apply liquid pressure to expel liquid from the lumen through the injection needle.
12. The catheter assembly of claim 1 wherein the guide wire extends through the needle.
13. A catheter assembly comprising:
an elongated flexible biocompatible tube constituting a guiding catheter and having a proximal end portion and a distal end portion;
an injection catheter disposed within the guiding catheter;
a reservoir adapted to contain treatment fluid and disposed within the injection catheter and at the distal end portion of the guiding catheter, said reservoir being defined by deformable side walls;
at least one needle adapted to protrude from the reservoir and beyond the distal end of the guiding catheter to a predetermined extent;
said at least one needle having a bore with an inlet communicating with the reservoir and an outlet disposed distally beyond the distal end of the guiding catheter;
operating means for delivering a predetermined quantity of treatment fluid from the reservoir through the needle outlet, said operating means comprising a source of fluid pressure applicable to the exterior of the deformable side walls of the reservoir to effect compression thereof for delivering said predetermined quantity of treatment fluid.
This application is a continuation of U.S. Provisional Patent Application No. 60/050,805, filed Jun. 26, 1997 and now abandoned.
This invention relates to delivery systems for drugs or biologicals, and more specifically to catheter systems for the delivery of drugs or biologicals to specific internal organs of the body, in precise, predetermined manner.
Catheters are, essentially, elongated flexible narrow-bore tubes used to gain access to body organs from the exterior of the body, through the body's natural ducts. They may be inserted, for example, through a patient's urethra to enter the bladder, to drain fluids therefrom or to deliver fluids thereto. They may be inserted into a major artery, and fed through the artery a considerable distance, e.g. to the vicinity of the heart. Instead of being used for the delivery or collection of fluids, they may be equipped with medical devices so that a specific medical procedure can be performed at a particular location of the artery, such as an angioplasty to relieve an occluded or partially occluded artery.
Accordingly, catheters have a number of very demanding technical criteria to meet. They must be flexible enough and thin enough to accommodate the contours of the body duct, without causing internal damage. They must provide reliable fluid communication over substantial distances. They must exhibit a high degree of biocompatibility. Their distal ends must be equipped with appropriate apparatus to perform their intended function. Commonly, such apparatus must be arranged so as to be operable from outside the patient's body, after insertion of the catheter to its correct location.
There are instances where, for critical therapeutic purposes, it is necessary to inject a patient's myocardium with a therapeutic fluid, such as a DNA solution, in very small amounts and at a precise location. The myocardium is the middle, cardiac muscle portion of the heart wall, surrounding the heart chambers. It is the thickest part of the heart wall, having a maximum thickness, in the ventricle walls, of about 2.5 cm. Blood vessels permeate the myocardium. The capillary beds therein are so extensive that more oxygen is released in the myocardium by the circulating blood than in any other organ of the body. Localized treatment of the myocardium to treat muscular damage thereto, e.g. with therapeutic substances, is sometimes needed. Very precise control over the location and delivery of such therapeutic substances is accordingly necessary. Very small amounts of very expensive therapeutic substances such as up to 0.05 ml of DNA solution are often required to be delivered, with precise control over location and quantity.
It is an object of the present invention to provide a novel catheter for fluid delivery to internal organs of a mammalian body.
It is a further object of the invention to provide a catheter specifically adapted for delivering fluids to the myocardium.
The present invention provides a novel form of fluid delivery catheter assembly capable of delivering therapeutic fluids to a precisely controlled, predetermined location of an internal organ of the body such as the myocardium. The fluid delivery catheter assembly comprises (a) an elongated flexible biocompatible tube effectively constituting a guiding catheter; (b) one or more injection needles at the distal end of the guiding catheter, the needles carefully arranged so that they can be inserted into, but will not protrude through, an internal organ wall such as a patient's myocardium; and (c) a reservoir adapted to contain therapeutic fluid, carried by the catheter and in fluid communication with the injection needles. An operating means is provided which can be operated exteriorly of the body being treated, when the catheter is in place, to deliver a predetermined quantity of fluid from the reservoir to and through the needles. The catheter assembly is adapted for insertion through a vascular structure of the body, to an internal organ. In the case of treatment of the myocardium, the catheter assembly may be inserted through either of the right or left femoral vein or right or left jugular vein into the right ventricle, to effect injection into the ventricular septum. Alternatively, the catheter assembly can be deployed in the left ventricle, with approach through either right or left femoral artery or right or left brachial artery, and injection in either ventricular septum or anterior or inferior or posterolateral left ventricular free wall. The shape of the distal end portion of the catheter assembly can be arranged to meet the manner of intended approach and injection.
FIG. 1 is a diagrammatic four-chamber view of a human heart, and illustrating diagrammatically and in broken lines three alternative ways for insertion of a catheter according to the invention;
FIG. 2 is a detail diagrammatic view of the distal end portion of a catheter according to a specific preferred embodiment of the invention;
FIG. 3 is a general diagrammatic view of the catheter of FIG. 2, in two alternative forms thereof;
FIGS. 4A, 4B and 4C comprise three sequential diagrammatic views of the distal end of the catheter of FIGS. 2 and 3, showing different stages of the operation thereof;
FIG. 5 is a diagrammatic detailed view of the distal end of a catheter according to a second embodiment of the invention;
FIGS. 6 and 6A are diagrammatic detailed views of a third embodiment of the invention;
FIGS. 7A and 7B are diagrammatic detailed views of the distal end and operating means of a fourth embodiment of the invention;
FIGS. 8A and 8B are diagrammatic, cross-sectional views of the distal end of a fifth embodiment of the invention, in two different operational positions; and
FIG. 9 is a diagrammatic cross-sectional view of a sixth embodiment of the invention.
One preferred form of reservoir for use in the fluid delivery catheter of the present invention is a cartridge, removably and slidably mounted in the distal end portion of the guiding catheter. Such a cartridge is suitably cylindrical, so as to fit slidably inside the distal end portion of the guiding catheter, and to be moveable towards and away from the distal end of the guiding catheter. It is thus a custom made unit, sized so as to contain from 0.05-10 ml of fluid. Most preferably, its proximal end is in the form of reciprocal plunger, adapted to move in increments towards the distal end of the cartridge.
The distal end of the cartridge is suitably equipped with a mounting plate carrying one or more needles which protrude distally therefrom a suitable distance for effective fluid delivery as required, namely 1-8 mm. The needles have central bores which communicate with the interior of the cartridge, and one or more (up to about 10) outlet openings in the length of their extent beyond the distal end of the cartridge. Thus the outlet openings may be disposed radially or axially of the needle. In such an arrangement, each incremental movement of the plunger toward the distal end of the cartridge can cause the expulsion through the injection needle(s) of a predefined aliquot of liquid, e.g. of volume 0.05-0.5 ml, from the cartridge.
Other preferred embodiments of the invention have the reservoir in the form of a chamber in an interior injection catheter, in fluid communication with the injection needle(s), the injection catheter being adapted to be received within the guiding catheter. Biological fluid may be expelled from the chamber through the injection needle(s), in known, predetermined amounts, by application of pressure to the fluid in the chamber. This can be accomplished, for example, by compressing the chamber by application of external pressure to resilient walls of the chamber, or by direct application of fluid pressure to the liquid in the chamber from the proximal end of the catheter assembly.
Some preferred embodiments of the invention include a guide wire extending along the inside length of the guiding catheter and through the reservoir and needle. This guide wire is moveable lengthwise relative to the guiding catheter. It can be arranged to protrude distally beyond the distal end of the guiding catheter. Such a guide wire, being of smaller diameter, is more flexible and capable of more intricate shaping than the guiding catheter, e.g. into sharper curved shapes, necessary to allow contact with portions of the myocardial wall which present access difficulties. When, for example, access to the myocardial wall of the left ventricular chamber via the aortic valve is required, the catheter must negotiate fairly sharp curves in the artery for access. A flexible, shape assuming guide wire as the leading element of the catheter of the present invention in such an arrangement is advantageous in such applications. When the guide wire has been placed in position against the myocardial wall, the guiding catheter and associated reservoir can be moved along it, ready for injection of drug. The guide wire suitably protrudes also from the proximal end of the guiding catheter, so that the operator can use both the guide wire and the guiding catheter to insert and place the catheter in the correct position. In some embodiments, the guide wire can also act as a stiffener for the guiding catheter. Suitable guide wires are available on the market.
Some preferred embodiments of the invention suitably includes an injection catheter disposed inside the biocompatible tube and extending along the length thereof. When the embodiment includes a cartridge with a reciprocal plunger, the injection catheter may have its distal end connected to the plunger comprising the proximal end of the cartridge, so that the injection catheter effectively forms part of the operating means. It is connected at or near its proximal end to a fluid pressure injector so that the plunger can be moved hydraulically by means of a syringe or similar device, to deliver fluid from the cartridge to the needles.
The biocompatible tube comprising the guiding catheter is suitably made of polyethylene, or other suitable artificial plastic substance with appropriate flexibility and biocompatibility such as nylon, polypropylene, etc. Typically, it has a length between 1 meter and 2 meters, and a diameter between 4 F and 8 F (1.5-3.0 mm). It may have a central lumen to accommodate an injection catheter and a distal end portion for containment and deployment of drug delivery components. The distal end portion of this guiding catheter, of length approximately 1-15 cm, may have a variety of different shapes, to facilitate reaching a particular myocardial wall for which it is employed. The individual shapes are largely determined by the approach which the operator intends to take, to the treatment of the internal organ such as the myocardium, and the disposition of the portion of the organ which it is intended to penetrate and treat. Thus the distal end portion thereof may comprise a straight catheter, or a curved portion with the arc of curvature varying between 30� and 180�. It can be of S-shape with varying degrees of arc in the proximal portion and the distal portion of this end portion. The distal endmost portion can be U-shaped, over its 0.5-2.0 cm distal tip length, with varying degrees of the arc. It can have more than one angularly disposed portion, with a first, proximal end angulation in the range 90-160� and the second, distal end angulation portion being in the range 100-170�. The distal tip of the guiding catheter may be straight or angular with respect to its length, with angles varying between 90� and 160�.
A special type of guide wire for use in the present invention, in a preferred embodiment thereof, includes a screw attached to its distal end, adapted to protrude beyond the distal end of the cartridge and the guiding catheter so as to be available for direct contact and attachment to the myocardial wall. This allows for accurate placement of the catheter on the myocardial wall, and retention in place of the apparatus on the preselected portion of the myocardial wall while the injection of fluid from the cartridge into the myocardium takes place.
A feature of the preferred catheter assemblies of the invention is the limitation of the protrusion of the injection needles to not more than about 2.5 cm, most preferably not more than about 8 mm, beyond the distal end thereof, even when fully extended. This ensures proper penetration into the thickness of the myocardium for treatment thereof, e.g. to repair damaged vessels, without risk of full penetration through the entire thickness of the myocardium. Means for monitoring the position and penetration of the injection needles may be included on the assembly, such as tip electrodes on the needles and reference electrodes on the body of the assembly which, with appropriate, standard electrical circuitry will give the operator an audible or visible signal when contact and/or appropriate penetration of the treatment site has been achieved. Parts are also (or alternatively) rendered radiation opaque so that the operation of the catheter assemblies according to the invention can be monitored on screen as it is conducted.
FIG. 1 of the accompanying drawings diagrammatically illustrates the human heart, and three alternative ways in which catheters of the present invention may be inserted, to permit injections into the myocardium at different general locations. The heart has four chambers, namely a right atrium 10, a left atrium 12, a right ventricle 14 and a left ventricle 16. The ventricles are capable of a pumping action, and are lined with a muscular wall, the myocardium, which creates the pumping action. Treatment of the myocardium to improve or repair its function is sometimes necessary. The present invention provides catheters suitable for this purpose:
The superior vena cava 18 is a main body vein, communicating with the right atrium 10, which in turn communicates via the tricuspid valve 20 with the right ventricle 14. The inferior vena cava 24 is another main body vein communicating with the right atrium 10. Accordingly, a catheter according to the invention can be inserted into the right ventricle 14 for treatment of its myocardial wall either via superior vena cava 18 and tricuspid valve 20, as indicated by broken line C1. Alternatively, it can be inserted through the inferior vena cava 24, right atrium 10 and tricuspid valve 20, into right ventricle 14, as indicated by broken line C2. The left ventricle 16 is similarly accessible through femoral artery 22, left atrium 12 and aortic valve 26 as indicated by broken line 23.
FIG. 2 of the accompanying drawings shows diagrammatically the distal end portion of a catheter 28, according to a preferred embodiment of the invention. Its distal end portion 30 contains a reservoir 32 in the form of a cartridge slidable within the distal end 30 of the catheter 28. Protruding from the end of the cartridge 32 to the distal end 34 of the catheter is a needle 36 in communication with the interior of the cartridge 24. Within the cartridge 32 is a plunger 38 which can move up and down within the cartridge 32 and closely engages the interior walls of the cartridge 32 in a slidable manner. As shown in FIG. 3, the plunger 38 may be mounted on an operating wire 40, or in the alternative with a conduit catheter 46, either of which extends through the length of the catheter 28 to its proximal end, where it is operatively associated with a mechanical device or hydraulic device respectively, adapted to move the cartridge 32 towards the distal end 34 of the catheter 28 and, at the termination of that movement as described below, to move the plunger 38 within the cartridge 32 towards the distal end 34 of the catheter 28, to push the contents of the cartridge 32 into and through the needle 36.
Thus referring to FIG. 3, the complete catheter 28 has, at its proximal end, one of two alternative operating mechanisms. The first is a hydraulic system where the proximal end of the catheter has a source of hydraulic pressure in the form of a hydraulic syringe 44 supplying hydraulic fluid to a conduit catheter 46 which extends to engage the plunger 38 within the cartridge 32. The second is a mechanical, wire activated system in which a scissor-type assembly 48 (or similar device such as a "loop and ring) is attached to one end of operating wire 40, to move it up on mechanical closure of the scissor handles 48 to move the plunger 38 attached to the distal end of the wire 40. The first portion of such movement, when the distal end 34 of the catheter is in contact with the wall of the body organ at the required position, serves to move the cartridge 32 relative to the catheter 28 towards the distal end 34 of the catheter, and to cause penetration of the needle 36 into the body organ walls such as the myocardium, to an extent limited by the length of the needle 36. Once the needle 36 has achieved full penetration, further movement of the plunger 38 takes place within the cartridge 32, and relative thereto, to expel the liquid contents from the cartridge through the needle 36 into the penetrated body wall.
This is further diagrammatically illustrated in FIG. 4. In FIG. 4A, the distal end 34 of the catheter 28 is positioned against the myocardium 52 to be injected. The cartridge 32 is withdrawn within the distal end portion 34 of the catheter, and the plunger 28 is positioned towards the proximal end of the cartridge 32. On operation, the operating wire 40 moves towards the distal end 34 of the catheter, the cartridge 32 moves towards the distal end, with the plunger 38 remaining at the proximal end of the cartridge 32, so that the needle 36 penetrates the myocardium, thereby assuming the position shown in FIG. 4B. The next operation cannot cause any further movement of the cartridge 32 since it is already at the distal end 34 of the catheter 28 and in contact with the myocardium 52. Accordingly, this additional pressure causes movement of the plunger 38 within the cartridge 32 to expel therapeutic liquid from the cartridge through the needle 36 into the myocardium 52, as indicated in FIG. 4C.
By appropriate choice of length of needle 36 in the catheter of the present invention, penetration of the body organ wall such as the myocardium to an exactly predetermined extent can be arranged, so as to allow treatment of the myocardium 52 with therapeutic fluid without penetration thereof to the layers beyond. This makes the best possible use of the therapeutic fluid, and is particularly advantageous in the case of the use of very expensive therapeutic fluids such as DNA solutions for myocardial treatment. The apparatus can be arranged to deliver aliquots of fluid over volumetric range of 0.05-1 cc's. The apparatus can be arranged to deliver such an aliquot incrementally, by controlling the extent of movement of the plunger 38 within the cartridge 32. Thus there can be delivered a volume corresponding to the entire internal volume of the cartridge 32, or a carefully controlled portion thereof, depending upon the extent of movement of the plunger 38 therein.
FIG. 5 of the accompanying drawings shows the distal end portion of an alternative form of catheter according to the present invention, in which cartridge 32 is slidable within a guide catheter 54 and is mounted on the end of an injection catheter 58 which is moved by the operating means to position the cartridge 32 so that the needle 36 carried by it bears against and penetrates the myocardium. As in the previously described embodiment, the cartridge 32 contains a slidable plunger 38, which can be moved in response to movements of the operator wire 40 to expel liquid from the cartridge 32 through the needle 36, in the manner described with reference to FIG. 4.
FIGS. 6 and 6a show a further alternative embodiment, similar to that shown in FIG. 5 but in which the cartridge 32 is equipped with a plurality of needles 36' for injecting into the myocardium, and which is additionally provided with a guide wire 60, extending through a centrally disposed tubular operating wire 40. The guide wire 60 extends beyond the distal end of the guide catheter 54, through cartridge 32, to lead the catheter into position against the myocardial wall 52. This facilitates access to parts of the myocardium where the catheter must make relatively sharp angled bends. When the guide wire 60 is in position against the myocardium, the operator can cause the guide catheter 54 and associated structure to slide along the guide wire 60 into position, and then the operator wire 40 can be operated to move first the cartridge 32 distally and then the plunger 38 distally within the cartridge 32, as indicated in FIG. 6A, and according to the steps illustrated in FIG. 4.
FIGS. 7A and 7B show alternative operating systems for use with catheters previously described. Both show the FIG. 6 embodiment. In FIG. 7A, the operating means for the plunger 38 and cartridge 32 is a mechanical scissors-style pivoted handle 48', one jaw of which is connected to operator wire 40 and the other to catheter 54, for relative movement thereof on pivoting the handle 62, through the operating stages shown in FIG. 4.
In FIG. 7B, the operator means is a hydraulic syringe 64 with a piston 66, the operation of which delivers hydraulic fluid under pressure through a conduit catheter, to move the cartridge 32 and plunger 38 through the operating stages shown in FIG. 4.
In alternative arrangements, the needle may be provided with a series of outlets, along the length thereof, as well as an outlet in its end tip. The needle may be designed in the form of a screw so that it can be used to penetrate and attach itself and the cartridge containing the drug directly to the myocardium. This arrangement secures the intramyocardial injection either through the end hole or through the end hole and side holes of the screw like needle.
In addition, a special type of guide wire may be used which contains a screw attached to its end to allow direct contact and attachment to the myocardial wall using the guide wire. Such a guide wire can be advanced through the guiding catheter and injecting catheter and the cartridge containing the drug, to be attached to the myocardial wall beyond the distal end of the catheter. After such attachment, direct intramuscular injection into the myocardial wall can be arranged.
Many other practical embodiments are encompassed by this invention, those described and illustrated being non-limiting examples. For example, in one alternative specific embodiment of the invention, not illustrated, the catheter comprises a flexible tube with at least one hollow injection needle mounted on and extending beyond its distal end, the needle or needles having an extent of protrusion of from about 1-8 mm. This length is chosen to be less than the thickness of myocardial wall. A guide wire extends through the length of the catheter, and through or around the needle, to lead the catheter into position against the selected portion of the myocardial wall. A mechanical operating means in the form of a syringe is provided at the proximal end, connected to an operating plunger at the distal end portion of the catheter. Thus, the portion of the catheter between the distal end thereof and the plunger provides the reservoir for therapeutic fluid carried by the catheter. Such an embodiment, omitting the guide wire, is described and illustrated below with reference to FIG. 9 of the accompanying drawings. In this embodiment, the catheter containing therapeutic fluid is led into position by the guide wire, further pushed by the operator until the needle(s) penetrate into the myocardial wall, and then the operating means is manually operated to expel the therapeutic fluid through the needle(s) into the myocardium. The operation is monitored on screen, as it is performed, as in the case of operation of the various other embodiments disclosed herein.
FIGS. 8A and 8B of the accompanying drawings diagrammatically illustrate a further embodiment of the invention. Instead of a cartridge, the reservoir for the therapeutic fluid to be injected comprises a chamber 70 at the distal end of the injection catheter 58, in fluid communication with and carrying an injection needle 36. The needle 36 extends beyond the distal end of the injection catheter 58 a predetermined distance appropriate for injection of fluid into the myocardium, as previously described. The chamber 70 is defined by compressible side walls 72 so that the chamber 70 can be compressed to expel the contents thereof through needle 36, as shown in FIG. 8B, by application of external fluid pressure to the side walls 72.
To accomplish this, the embodiment of FIGS. 8A and 8B includes an outer tube 74 of biocompatible material e.g. medical grade polyethylene, constituting a guiding catheter, and an inner tube 76 constituting an injection catheter and defining an annular space 78 between itself and the guide catheter. A source of fluid pressure e.g. compressed air can be connected to communicate with space 78, towards the proximal end of the catheter assembly, so as to pressurize the space 78 when required. The side walls 72 defining the chamber 70 are of softer material than that of the rest of the inner tube 76, although sealingly joined thereto, so that fluid pressure supplied to space 78 compresses chamber 70 to expel the contents thereof through needle 36 when required, without affecting inner tube 76. In practice, fluid for injection such as genetic material is introduced into the chamber 70 by means of a small injection needle through needle 36, so as to fill chamber 70. Then the injection catheter (inner tube 76) is introduced into the guide catheter tube 74, which may already be in place at the injection site. The injection catheter 76 is a sealing fit in the guide catheter 74. The injection catheter remains in the guide until it is positioned properly. The needle then is advanced out of the guide to penetrate the myocardial wall, or other chosen injection site, and injection fluid in predetermined measured amounts can be expelled through the needle 36 to the injection site at will, by supply of pressure to space 78. With the guide catheter 74 still in place, the injection catheter can be removed and reloaded.
Different relaxed sizes of chamber 70 can be adopted either by changing the diameter or by changing the length of the chamber, to accommodate different volumes of injection fluid.
The embodiment of FIGS. 8A and 8B also optionally includes a recording electrode 80 in the form of a ring around the distal, penetrating end of needle 36, and a reference electrode 82 disposed some 10-15 cm from the tip. With suitable, standard electrical circuitry arrangements, the recording electrode 80 can give the operator a visible or audible signal to indicate contact of the tip of needle 36 with the injection site or, alternatively, penetration thereof to the desired, predetermined depth, such as 2 mm, so that the operation of the injection procedure can commence. Similar recording and reference electrodes can be included on the other illustrated embodiments of the invention. Distance markers can also be included in appropriate locations.
FIG. 9 of the accompanying drawings illustrates a further embodiment of the invention. In this embodiment, the injection catheter 58 includes an injection lumen 84 of very small diameter, which serves as the reservoir for injection fluid and communicates with the injection needle 36 protruding from its distal end a short, predetermined distance such as 2 mm. The lumen 84 is defined by tubular side wall 86, e.g. of nylon, dimension 0.05"�0.010". This injection catheter 58 can be used with a guide catheter of the type shown on item 74 on FIGS. 8A and 8B. In operation, the lumen 84 is loaded with genetic injection fluid from its proximal end using a syringe 88, until a meniscus is formed at the distal needle 36. Depending on the amount of injection material required, the syringe 88 can be left in place on the proximal end, for additional injections. Then the injection catheter is introduced through a guide catheter, positioned at the location for injection, and the injection catheter is advanced 60 that the needle 36 penetrates the location, e.g. the myocardium. The exact amount of fluid can then be injected by operation of the syringe 88 on the proximal end. The catheter assembly can then be moved to the next area for injection, and the process repeated. A catheter of this design may have a length of 100 cm and a lumen diameter of 0.01 inch, giving an approximate capacity of 0.05 cc of injection fluid. With such a small volume lumen, very little injection fluid is lost.
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Bug: Klingon Invasion Begins
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Lt. Commander
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Bug: Klingon Invasion Begins
I noted this on my Orion Maruader, my transwarp does not take me to the Klingon homeworld but says Transwarp to Sol. I thought perhaps it was text bug and clicked on it. And arrived in Sol System.
PS though I can't enter Earthspace dock, I can begin the docking procedure, see the interior. Couldn't fire my torpedos but I was able to eject my warp plasma and gas the bugger.
Attention Klingon Command:
Trans pIvghor Daq Sol Qapla'ta' naw' Daq norghlogh vergh Qapla'ta' ra' Hoch yo' Daq tagh yot


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The Feast of Alex Comfort (celebrated with a book review)
Author Alex Comfort is, of course, best known for his book The Joy of Sex, and there is plenty of sex happening in Tetrarch, where the customary greeting is, "Have you loved well?" Narrator Edward and his partner Rosanna are preposterously enlightened in their sexuality: quite free of jealousy and compassionate about others' hang-ups. It's not porn; there's none of the sort of graphic detail that makes porn work, but the sexual vision--utopian and otherwise--is rather inspiring. ( Read more...Collapse )
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Buy Tickets Freaky Fridays
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August 29, 2014
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Unconventional filmmaker Jarmusch turns to suburbia
By Larry Fine
NEW YORK (Reuters) – Filmmaker Jim Jarmusch, known as a
cinematic risk-taker, is now taking chances in an unexpected
way — by flirting with the mainstream in his latest movie,
"Broken Flowers."
The comedy starring Bill Murray drops the stark settings
associated with the art house darling's earlier work and
instead offers a tour of the suburbs and a reflection on life
and love.
Countering its swerve toward conventionality by maintaining
an eccentric beat and sensibility, the film by writer-director
Jarmusch won the Grand Prix prize at the Cannes Film Festival
and begins playing in U.S. theaters on Aug. 5.
"This is an odd one for me," said Jarmusch, who made his
mark with quirky, darkly comic, artistic films like "Stranger
Than Paradise (1983) and "Down By Law" (1986) that often depict
journeys, examine fate and look at life from an outsider or
foreigner's perspective.
"Broken Flowers" offers some familiar strands but its
odyssey through a suburban world takes the filmmaker outside
his comfort zone.
Jarmusch dislikes his main character, which he created
expressly for Murray. He abhors retrospection yet has his
protagonist confront his past four times over and sheds his
'guy film' image by using an array of actresses including
Jessica Lange, Sharon Stone, Tilda Swinton and Frances Conroy.
In "Broken Flowers," devout bachelor Don Johnston has been
dumped by his latest lover and resigns himself to being alone.
But an ex-lover's anonymous letter telling him he fathered a
son 19 years earlier moves Johnston to confront his past.
Goaded into action by his Ethiopian neighbor, played by
Jeffrey Wright, Johnston seeks out his former lovers, getting a
glimpse of his past and a taste of what might have been.
"I don't identify at all with Don Johnston at the
beginning. I don't even like him. That's very unusual for me.
In all my films, no matter how damaged or socially inept
characters may be, I really feel for them. I love them.
"I don't love Don Johnston. I don't care about some rich
guy that made money off computers, had pretty girlfriends and
doesn't know what he's doing."
So topsy-turvy was the experience that Jarmusch did the
editing process in reverse — starting from the last scene and
working backwards.
"I didn't feel for him in the beginning, but I want to feel
for him in the end," Jarmusch said about his protagonist. "It
was six weeks of editing before we started looking at the
film's beginning."
The beginnings of the project included a New York night
stroll with Murray.
"We walked all the way from the Lower East Side to the
Upper East Side (about 4 miles) talking the whole time,
preparing the character," said Jarmusch, who prefers shaping a
character with an actor rather than rehearsing scenes.
"We were talking about our lives, human nature and love,
and love stories and things that misconnect and why they
Jarmusch said he consciously tried to create strong female
characters in this project.
"In my life I've learned a lot more from female friends and
lovers and people close to me than I have from male friends,"
he said. "Maybe because I don't understand them completely.
"A lot of my female friends said, "'Down By Law" is really
a boys' movie, and "Ghost Dog" is really a boys' movie, and so
is "Dead Man." We like them but you make boys' movies.'
"Well, I'm a boy, you know?"
One trademark element in "Broken Flowers" is a provocative
soundtrack, including a mesmerizing lead-in song, "There Is An
End," by The Greenhornes featuring singer Holly Golightly.
Jarmusch said he feels no urge to join some new wave
directors who have found big-budget studio collaborations.
"To me, I like the margins. I'm not a mainstream guy.
Whether it's literature or music, the mainstream doesn't speak
directly to my heart, and that's where I get inspired by the
world of ideas," Jarmusch said.
"Where they cross with business is a very complex thing.
But I don't do this for business. I do it because I love ideas
in the form of filmmaking."


text:
Waka Flocka Flame and DJ Whoo Kid are the true "Turn Up Godz". Check out their wild and crazy video.
Snoop Dogg – California Roll (ft. Stevie Wonder & Pharrell Williams) [Video]
Snoop Dogg kicks off his new album 'BUSH' with his latest video for "California Roll" produced by Pharrell Williams.
Troy Ave – Doo Doo [Video]
If you a hater… you know the rest! Check out Troy Ave's "Doo Doo."
Machine Gun Kelly Opens Up About Dating Amber Rose!! [Video]
Machine Gun Kelly finally opens up about dating Amber Rose on Hot 97!
New Video: Meek Mill – Monster
Check out the new video from Meek Mill called "Monster."
Nicki Minaj and Beyoncé – "Feeling Myself" (Teaser)
Head over to Tidal to watch Nicki Minaj's new "Feeling Myself" video featuring Beyonce!
Here's the teaser below.
Taylor Swift – Bad Blood ft. Kendrick Lamar [Video]
Fresh off a victorious night at the Billboard awards, Taylor Swift releases her music video for "Bad Blood," featuring Kendrick Lamar.
Soulja Boy – Lingo (Watch Me Swag/Juice)
The newest member of Birman's Rich Gang, Soulja Boy, drops his latest video Lingo (Watch me Swag/Juice).
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- Next Page»


text:
Potential merger may create the world's largest telecommunications operator
AT&T may be taking over Europe's largest mobile phone network, Vodafone, the same company that created Verizon.
AT&T Inc. (T) executives are laying the groundwork internally for a potential takeover of Vodafone Group Plc (VOD) next year, mapping out a strategy for a complex deal with Europe's largest mobile carrier, people familiar with the situation said.
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Mr. Thomsen
Special MemberCommunity profile
Last Activity: Today 11:40 AM
About Me
- About Mr. Thomsen
- Biography
- Holds degrees in media, film, and journalism. Terrible but enthusiastic dancer when drunk.
- Location
- Denmark
- Interests
- Film, literature, games, horror, full contact karate, vintage movie posters, neuroscience
- Occupation
- Has worked freelance in film and TV since 2000 and is writing a textbook on horror film
- Most wanted blu-ray upgrades: Kafka, The Limey, Suspiria (remaster), Castle of Blood, The Horrible Dr. Hichcock, Blood and Black Lace, Kill Baby Kill, L'avventura, Don't Look Now (remaster), The Changeling (1980), Ringu, Ju-on, Miracle Mile, The Honeymoon Killers, Man Bites Dog, Cannibal Holocaust, Creature (The Titan Find), Irrèversible, The Fearless Vampire Killers, The Black Hole, The Sentinel (1979), Carnival of Souls, Cat People (1942), I walked with a Zombie, Don't Go in the House.
Showing Friends 1 to 4 of 4
- bgart13
- Special Member
- dsman71
- Blu-ray Ninja
- EddieLarkin
- Blu-ray Guru
- The Great Owl
- Blu-ray Champion


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View Poll Results: Drawing time?
- Voters
- 67. You may not vote on this poll
Less than an hour a day
1-3 hours a day
3 - 6 hours a day
I'm a pro, so I spend practically all my time drawing.
Results 1 to 17 of 17
Thread: Time you spend drawing
December 20th, 2009 #1
Time you spend drawing
Has anyone ever heard one of those "I used to draw *insert exaggerated time lapse*", that makes anybody feel like "God this is a real artist" and "I have to practice more"?
My question is if those were actually working that hard. I mean, it is GOOD to have artistic life and give it its time, but they would also work and study, eat, sleep,... so be like spending 25 hours a day drawing seems almost impossible to me.
Straight to the point.
What's your actual drawing time?
Hide this ad by registering as a memberDecember 20th, 2009 #2
I try and clock in 30 minuets. The problem is I get bored very quickly. I also have a short attention span. After awhile drawing can become very boring,you sometimes feel its not even worth it and that you want to do something eles like watch Tv,or play on the computer. I rarely watch TV,so messing about on my Laptop is what does it for me. Listening to music sometimes helps as complete silence is very boring,however listening to the same song over and over won't help much. If you want to clock as much as time as possible on your art you just need to enjoy yourself,don't keep doing the same part over and over,try something different,like experimenting with colours
December 20th, 2009 #3
If we even need this discussion at all perhaps we can keep it in one current thread at a time.
December 20th, 2009 #4
this seems to be a huge concern for people lately.. not sure why
"We are the music makers... and we are the dreamers of dreams."
December 20th, 2009 #5
The only questions which are relevant are:
How much time are you spending on drawing? - are you making good progress? - if not, how much extra time could you spend? - and - do you realise that its not just about the amount of time you are practicing, but whether you are doing the right sort of practice; so are you making best use of the learning resources available to you, books, info and help here and elsewhere online, local teachers, etc...
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December 20th, 2009 #6Sheriff
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Zero time, to five minutes, to.. I dunno. Longest time I spend drawing before I need a break is about 3 hours. How LONG do I spend on a drawing? As long as it takes... 5 minutes to... I dunno...
December 20th, 2009 #7Registered User
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I'm drawing for 5, 10, maybe 15 minutes per day. It's been a long time since I really drew, so I think I'd burn out if I tried to study for an hour or more every day. I'll start increasing my time once drawing daily has become a habit again. Hopefully I'll have re-established the connection between getting ideas and drawing them by then, plus I'll have re-built my confidence.
December 21st, 2009 #8
If you want to succeed at any career...you have to really work at it. Top concept artists and illustrators are the top because they dedicate themselves to it. The same with top CEO's of fortune 100 companies or a doctor at the top of his field...
So, if you want to be at the top, you gotta draw all the time It's not a goal for everyone though, some people just want to get by while focusing on other things (like a social life! hehe).
December 21st, 2009 #9
About 12 hours. It never seems enough.
December 21st, 2009 #10
Depends on what other things I have going on in the week, but my normal for draft to finished works is around upto 6 hours or sometimes more. I enjoy drawing and have alot to express, or keep myself inspired. I'm doing it for fun, and working into the biz. I second what Ivory commented.
December 21st, 2009 #11
If you want to improve....the more time the better. Of coure, you should take frequent breaks, to let your eyes rest. If you don't have anything to draw, I would suggest picking up Peck's Anatomy of the artist and start drawing the structures in there. They can be very complex to get perfect, but once you can do that...you are on your way to being a very good life/character artist.
December 21st, 2009 #12
I spend around 19 hours a week drawing, so divide it by 7 days and it's 2.7 hours a day. I wish I can draw more, but well, when you're having a 8.5 hour job from Mon - Fri + night classes on Tue and Thur, it's hard to find time.
God, pls grant me 48 hours a day, and I'll use the remaining 24 hours to draw and draw and become old-master-level by the age of 35.
My blog and Sketchbook.
"There are no gods, only Glenn Vilppu."
Do you draw in the Vilppu / Sheldon style?
The Penvirate Sketchbook!
Diarum ::Kamber Parrk
December 21st, 2009 #13
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December 21st, 2009 #14Registered User
- Join Date
- Apr 2009
- Location
- Milwaukee, WI
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- 82
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- Thanked 24 Times in 20 Posts
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I try to draw for at least an hour a day, even though I have to break it up into chunks. Most days I'll do some studies during my 1/2 hr lunch break, and then doodle for at least another 1/2 hour when I get home (but I try to do more, if I'm not too tired). I figure it's good to get in the habit of at least trying to draw something every day, so it doesn't fall off my radar, like exercise seems to do...
K J Dawson's KreativeWerks - my new daily sketch blog (more like almost-daily...)
My DeviantARt page - some of my "finished" works; updated sporadically
December 23rd, 2009 #15
Personnally, I think that the most important issue is to realize why you draw instead of the amount of time that you dedicated to this activity. Find the way to use the energy to set up tools adequate to serve your creativity.
My approach is based on the theory that each of the works is dependent on the previous ones and allows the continuity. And all the different steps has the similar importance, it's the coherence which brings the creative energy which I need.
Finally, I think that every individual is the best judge on his own needs.
December 23rd, 2009 #16
It's not how many hours that counts but how much you put into those hours.
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December 23rd, 2009 #17
First of all I don't take time really and secondly I think the way the poll is made is very limiting so I didn't vote. I'm not clockwork. There are days when I literally don't draw at all for whatever reasons and there are days when it's all I do (and all the in between amounts) Generally I see no point in "making time" to draw just to meet some x hrs a day. It's unproductive, fruitless, pointless, irritating, tedious labour. You need to feel it.
Last edited by nofu; December 23rd, 2009 at 07:36 PM.


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Remember very soon the big ole yellow school buses will be out and they will be carrying precious cargo- our children- back and forth to school. So be very watchful, a kid might just dart across the road right in front of you.
Wanda Coursey, as far as I know, is at hoe from a recent hospital stay in the Medical Center. Wish she could get to feeling much better.
I had the best time one day in the past week when Delores Renfro from Russellville came down and we had lunch. We had a most enjoyable time. She- like me- likes to talk, so we had a great time.
David and Stacey Jernigan brought my supper Tuesday night.
Sorry Jewell Wayne Johnson has been in the Medical Center in Bowling Green and has had to be transferred to Creekwood in Russellville for therapy.
Visiting recently on the 17th with Helen and Glenn Porter and Rex, was her cousin Donna Rithie and her daughter Julie of Waterford, Michigan. They enjoyed seeing them.
And then on July 4th were Marty and Shelly Scarbrough and Blane of Wisconsin. Isn't it nice to have surprise company? Usually when that happens here… wow! Sh9ould have swept the floors, dusted and at least had a halfway house you can get into, right? Yeah.
They also visited his parents Wilford and Jeri Scarbrough of Auburn and to her family members.
Get ready! According to the old folks story, when you hear the first katy-dids it should frost in 3 months. They were first heard by Glenn Porter on July the 4th.
James Fuller had to have some blood work done this past week.
I also had to get blood work done, will see Dr. Kamal Singh the 28th to get the report. Hope as usual it goes good.
Sunday afternoon at Crossroads church a "going away party" was held for granddaughter Tara and a friend of hers Kayla. They both will be moving next Friday and Saturday to college in Kansas City, Missouri to begin studies. A good sized crowd attended. We had all kinds of eats, even homemade ice cream, among other goodies and a few gifts. I'm sure the girls enjoyed it and appreciated all the love and support they were shown. Bye girls! We will miss you!
See ya next time and have a good week!


text: Frederick vs. North Hagerstown Girls Lacrosse 4/2 04/02/2012 10:51 PM 04/02/2012 11:47 PM Frederick vs. North Hagerstown Girls Lacrosse 4/2 By Associated Press 04/02/2012 11:47 PM Frederick traveling to North Hagerstown for Monday evening lacrosse action. HighlightsFrederick - 11North - 13FINAL Copyright 2013 Nexstar Broadcasting, Inc. All rights reserved. Page: [[$index + 1]] frederick high school high school/college sports local sports north hagerstown high school sports sports connection top stories


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Just arrived, a car is the 1950's Ford model on the top of everyone's list. The Club Victoria was the top of the line Fairlane... More
Just arrived, a car that was professionally built about ten years ago by a body shop owner. Amazing custom body panel work. Chrome and badging was... More
This classic car has been in storage since 1974. The body is in fair shape, with no rust. The interior is in good condition. The... More
This is the 2nd year of production for the T-bird. Automatic transmission, 312, and dealer installed A/C. Power steering, brakes, and windows. Yellow with... More
This Pontiac is a two-owner business coupe in original condition. I believe the odometer reading to be accurate. The car, purchased new in Chicago,... More
1956 Chevrolet C10 PickupThis truck was well built with alot of TLC. It has a V8 Automatic Transmission. 454 Jack Boyd Motor. It does... More
1955 Chevrolet 210 2 DoorThis 1955 Chevy 2 door hardtop has been completely restored!! Just received a New Paint Job and the car... More
1956 Chevrolet Bel AirMint condition56 Chevy Bel Air350 mild small blockAluminum headsDual exhaustV84 speed Muncie transmissionBrand new clutchPosse rearInterior is 100% Headliner seats carpet... More
For sale is a 1953 Cadillac Series 62 Convertible -Excellent original Arizona car -Clean Arizona title -Car is complete and rust-free -Restoration is approximately 75% complete -Body work is... More
Photo book nut and bolt restoration, folder of receipts, Chevrolet V-8 power @ 250hp, 4-speed close ratio trans, beautiful Silver blue paint with white... More
'57 Mercury INDY 500 Pace car convertrible, One of only 1,265 Pace Cars ever built & less than 200 left today! Pace cars came... More
1950 Chevrolet 3100.Please contact one of our expert sales consultants for the most complete information on this beautiful vehicle. They will be happy to... More
Offered for Sale by the California Automobile Museum 1956 DeSoto Seville Firedome We Offer Financing Exterior This DeSoto presents very well, no defects found in paint or bodywork. ... More
STK 1989 1955 Pontiac Star Chief Back in 1955, the Catalina Star Chief was the top-of-the-line Pontiac. This particular 2-door hardtop is a rust-free California... More
WORLDWIDE VINTAGE AUTOS Â CALL OUR SALES TEAM:Â 720-457-9145 MONDAY-FRIDAY: 10AM-5PM SATURDAY: 10AM-4PM Â AS ONE OF THE LARGEST... More


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PET IA Leighton is celebrating the ongoing production in their workshops with #1300 hand cranked cart assembled.
We are so grateful for financial contributions, volunteer hours worked and all those who partner with us in this ministry to give the gift of mobility.
Who needs a PET?
Millions of people in this world are in desperate need of mobility because of landmines, polio and other diseases, birth defects, and amputations. It is a life-changing event to go from dragging oneself in the dirt and mud to having three wheels to go wherever one wants to go! With a $250 donation we can build and ship one PET vehicle. The gift of a PET is at no cost to the recipient….it is the Gift of Mobility.
PETs are sturdy hand-cranked vehicles given freely to the recipient. The PET is a wheelchair that goes where wheelchairs can't go! More than 44,000 PETs have been distributed worldwide.


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Knight Frank recently released its Skyscraper 2015 Report. Find out which city has the highest skyscraper office rents in the world
Keuco's Architect and Design Centre in Wanchai brings the latest Keuco products to Hong Kong
The ISH China & CIHE will take place at the New China International Exhibition Center in Beijing in mid-May
They say a picture tells a thousand words. So what would the stories of Hong Kong be like in pictures?
The scheme recognises local companies that have established an effective framework for harnessing quality design
The annual international architectural event is inviting architects and designers to submit entries for its awards programme
Over 300 brands and galleries debut their designs at China's leading international design event
Find out who took home the big prizes


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Property Details
Apartment, 2 Bedrooms, 1 Baths, 4 Sleeps
Our newly renovated shore house is the perfect stay for your next summer vacation. Just grab your beach bag & head to the beach!
This second floor apartment is located within minutes of every attraction Wildwood has to offer. We're walking distance from sandy beaches, the World Famous Boardwalk, Morey's Piers (Waterpark), shops, restaurants, and bars. Our backyard is also the perfect escape for a backyard BBQ, and includes a full sized-screened in deck.
* Full sized & completely equipped Kitchen (see pictures below)
* Screened in Porch
* Bedroom 1 (Double Bed)
* Bedroom 2 (Double Bed)
* Bathroom
* Living Room
* **All Rooms have Air Conditioning
Recent Review
best vacation
About the Owner
2 Reviews
2 traveler reviews
best vacation
It is indeed a dream in North Wildwood!!
The apartment is designed to accomadate families and couples to relax in an enjoyable setting. The deck is extremely large,screened and completely furnished. A perfect area to sit back and enjoy the Jersey shore.
Activity and Interests
24th Ave is the prime residence location for families in Wildwood, we're a short walk from a playground as well as the beach & boardwalk. We also have a miniature golf course, great restaurants & bars, and a fireworks display every Friday evening.
More information can be found at the Wildwood, NJ tourism site.
Rental rates
|Rate Period
|Weekend Night
|Monthly *
My Standard Rate
Feb 1 - Feb 1
1 night
Fri, Sat, Sun
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.
Additional information about rental rates
- Refundable damage deposit $300.00
- Pet Fee $100.00
$300.00 deposit for weekly rentals with refundable $300.00 security deposit
$1,000.00 deposit for seasonal rental with refundable $500.00 security deposit.
Nightly Rate: $125 - $150
Weekly Rate: $875 - $975
Monthly Rate: $3200 - $3500
May 25to June 30,2010 $875.00 per week
July 1 thru September 4th $975.00 per week.
Monthly $3200-3500.00
Seasonal $9200.00
Security deposit of $400.00
- 12
- Available
- 12
- Unavailable
- 12
- Today
Property Type
- apartment
- Budget
- Family
- pets not allowed
Location Type
- Beach View
- churches
- coin laundry
- library
- marina
- playground
- restaurants
- water parks
- zoo
Leisure Activities
- gambling casinos
Local Services & Businesses
- ATM/bank
- fitness center
- groceries
- hospital
- laundromat
- medical services
Sports & Adventure Activities
- cycling
- golf
- sailing
- swimming
- tennis
- 1 Bathroom
- Bathroom 1
- 2 Bedrooms, Sleeps 4
- Bedroom 1
- Bedroom 2
- Our private fenced-in yard & gas grill is perfect for backyard BBQs. And our fully furnished outdoor porch is perfect for the Friday evening fireworks every week (also has ceiling fan to beat the Summer heat!) Our kitchen is fully stocked with all of the appliances you'll need: microwave, coffeemaker, toaster, etc. We also have cable and air conditioning for those hot summer days. This is the ultimate summer rental for couples & families with children of all ages. Small dogs are permitted at an additional charge.This is a non-smoking unit.


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AMD and NVIDIA released $250 GPUs last week, and both proved to deliver a major punch for modest cash. After testing, we found AMD to have a slight edge in overall performance, so to see if things change when OCing is brought into the picture, we pushed both cards hard, and then pit the results against our usual suite.
One of the more popular Internet memes for the past couple of years has been, "Can it run Crysis?", but as soon as Metro 2033 launched, that's a meme that should have died. Metro 2033 is without question one of the beefiest games on the market, and though it supports DirectX 11, it's almost a feature worth ignoring, because the extent you'll need to go to in order to see playable framerates isn't likely going to be worth it.
Manual Run-through: The level we use for testing is part of chapter 4, called "Child", where we must follow a linear path through multiple corridors until we reach our end point, which takes a total of about 90 seconds. Please note that due to the reason mentioned above, we test this game in DX10 mode, as DX11 simply isn't that realistic from a performance standpoint.
The larger buffer that the 2GB HD 6970 has kept it ahead of our overclocked 1GB card in this game, while NVIDIA's card kept super close to the GTX 570 at all three resolutions.


text:
Overton leads after bogey-free round
Updated: July 30, 2010, 10:50 PM ETAssociated Press
WHITE SULPHUR SPRINGS, W.Va. -- Boo Weekley's bum shoulder is improving and the self-proclaimed redneck has put down the fishing pole, hoping it might lead to a win at a tournament not named the Heritage.
Weekley equaled his best round of the year with a 7-under 63 on Friday on the Old White course to vault into second place, four strokes behind leader Jeff Overton, midway through the inaugural Greenbrier Classic.
Weekley hit 17 greens in regulation and had seven birdies during a bogey-free ...
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Earlier known as Bombay and later rechristened as Mumbai, the city has been one of the most buzzing cities across the world. Populated, culturally diverse and the financially critical to India, Mumbai is a city to reckon with.
Watch this video which shows a rather decades old Mumbai in black and white mode. Though many aspects of life have changed in the city, this video will show you exactly why is it still resplendent to its gone-by glorious age. Cosmopolitan and diverse describe Mumbai perfectly.
Watch the video below:


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The Human Centipede Puzzle
5,000 - 10,000 downloadsAdd this app to your lists
+ By IamBot
The game starts pretty easy, but on later stages it becomes VERY challenging even for the most experienced puzzle game players!
* 30 different stages and 1 bonus stage
* 10 unique game modes
* Amazing in-game music tracks and sound effects (recommended to use good headphones while playing)
More game content such as achievements, unlocking new features will be added soon.
Have fun playing! :)
Tags: human centipede 3, centipede, centipede game, human centipede game, centipede puzzle, the human centipede 3.
Version 1.01
* Music tracks varies more often
* Some other small changes
(37 stars)
(37 stars)
Fun, creative, tribute to a great movie. A nice challenge as well! Also GREAT customer relations!!
(37 stars)
I love the movies and now the game. Great Job!!!!
(37 stars)
Deserves NO stars at all. Did not like the graphics with the green screen (looked like someone being tortured) and you can't get out of tutorial mode even if you complete that level and no matter where you touch the screen.
(37 stars)
Pretty easy, should unlock pics or little vid clips of the movies as you pass levels to give you something to work towards. New review: Thank you for reply! That would have been awsum, if people are worried about space i think you should have 2 apps; this one and the same but with video clips id rather the larger game with video!!! Il rate 5 stars because you're the first dev to ever reply to me :
(37 stars)
(37 stars)
Gross fun for all ages!