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VNS Therapy(R) Effective at Reducing Depressive Symptoms in Patient Population Experiencing Chronic and Recurrent Treatment-Resistant Depression
HOUSTON, May 27 /PRNewswire-FirstCall/ — Cyberonics, Inc. (Nasdaq: CYBX) today announced the results of a multicenter, double-blind, randomized dosing study (D-21) conducted as a condition of the Food and Drug Administration (FDA) approval for VNS Therapy for patients with chronic and recurrent treatment-resistant depression in July 2005. This dosing study showed a consistent, sustained and clinically meaningful decrease in depression symptoms across all treatment groups as measured by multiple validated depression assessment scales. Four physician-rated depression scales and one patient-rated depression scale used in this study showed that adjunctive VNS Therapy provided efficacy that improved over time at all dosing levels. After long-term (50 weeks) treatment with VNS Therapy, overall depression symptom improvement ranged from 32.4% to 42.0%; response rates ranged from 26.7% to 53.3%; and remission rates ranged from 14.6% to 22.5% as measured by the five depression assessment scales.
D-21 compared the safety and effectiveness of adjunctive VNS Therapy administered at different stimulation levels to 331 adult patients enrolled at 29 U.S. study centers. Patients were randomized to receive one of three stimulation levels (low, medium or high) during the acute phase (22 weeks). The study design allowed patients in the low and medium stimulation groups to receive increased levels of stimulation after 22 weeks. Patients were followed in the study for a total of 54 weeks.
Patients participating in this dosing study were experiencing very severe levels of chronic and recurrent treatment-resistant depression that had been unresponsive to multiple antidepressant treatments. Key characteristics and demographics of study participants include:
Mean length of illness (years) 27.6 Mean age (years) 48.0 Mean length of current depressive episode (years) 9.0 Mean number of unsuccessful drug treatments (lifetime) 14.5 Percent previously attempting suicide (lifetime) 47.0 Percent treated with electroconvulsive therapy (ECT) (lifetime) 57.4 Mean number of lifetime hospitalizations for mood disorder 3.5
After 50 weeks of treatment, patients randomized to the medium stimulation group achieved an average of 42.0% improvement in depression symptoms from baseline as measured by the Montgomery-Asberg Depression Rating Scale (MADRS), one of the most commonly-used and extensively-validated rating scales to assess the range and change of depression symptoms in response to antidepressant treatments. Response, defined as greater than or equal to 50% reduction in depression symptoms, was achieved by 47.8% of patients, and remission, considered to be the absence of depression symptoms, was achieved by 21.1% of patients as measured by the same scale. Also, 80.6% of patients achieving response at 22 weeks maintained response at 50 weeks, indicating a high level of sustained response.
Patients receiving high stimulation did not show significantly greater improvement than those receiving medium or low stimulation at the end of the 22-week acute phase (the primary outcome measure). However, there was a statistically significant decrease in depression symptoms across all five depression scales over time, a secondary efficacy endpoint.
The overall trend and magnitude of depression symptom decrease is consistent with prior long-term VNS Therapy studies in similar patient populations experiencing chronic and recurrent treatment-resistant depression. Likewise, treatment-emergent side effects were similar to those previously reported for VNS Therapy in other studies.
"Chronic and recurrent treatment-resistant depression is a very debilitating illness–many of these people suffer for years without any improvement despite numerous treatment trials. Additionally, these patients are rarely included in clinical studies and very few effective treatment options exist for them," stated Charles R. Conway, M.D., Associate Professor of Psychiatry at Washington University School of Medicine and research faculty at St. Louis University School of Medicine. "In my 10 years of research and clinical use of VNS Therapy, I have seen unparalleled efficacy in a patient population for whom multiple standard-of-care treatments have failed. The long-term sustained efficacy seen with this treatment is particularly compelling and unique."
"The results of this post-market dosing study add to the growing body of evidence for adjunctive VNS Therapy in a severely ill patient population where multiple prior treatments have failed," said Dan Moore, President and CEO. "Efficacy that improves over time and lasts long-term in this patient population has been demonstrated in multiple studies involving approximately 1,000 patients. With these results in hand, we are continuing to evaluate our alternatives for addressing payer coverage and reimbursement and developing a business around the depression indication, while maintaining focus on our core epilepsy business."
About Cyberonics, Inc. and VNS Therapy®
Cyberonics, Inc. (Nasdaq: CYBX) is a medical technology company with core expertise in neuromodulation. The company developed and markets the Vagus Nerve Stimulation (VNS) Therapy System, which is FDA-approved for the treatment of refractory epilepsy and treatment-resistant depression. The VNS Therapy System uses a surgically implanted medical device that delivers pulsed electrical signals to the vagus nerve. Cyberonics markets the VNS Therapy System in approximately 60 countries worldwide, and to date more than 55,000 patients have been implanted with the device.
Additional information on Cyberonics and VNS Therapy is available at www.cyberonics.com.
Safe harbor statement
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended and Section 21E of the Securities Exchange Act of 1934, as amended. These statements can be identified by the use of forward-looking terminology, including "may," "believe," "will," "expect," "anticipate," "estimate," "plan," "intend," "forecast," or other similar words. Statements contained in this press release are based on information presently available to us and assumptions that we believe to be reasonable. We are not assuming any duty to update this information if those facts change or if we no longer believe the assumptions to be reasonable. Investors are cautioned that all such statements involve risks and uncertainties, including without limitation, statements concerning payer coverage and reimbursement for and developing a business around the depression indication for VNS Therapy. Our actual results may differ materially. Important factors that may cause actual results to differ include, but are not limited to: continued market acceptance of VNS Therapy and sales of our product; the development and satisfactory completion of clinical trials and/or market test and/or regulatory approval of VNS Therapy for the treatment of other indications; satisfactory completion of post-market studies required by the U.S. Food and Drug Administration as a condition of approval for the treatment-resistant depression indication; adverse changes in coverage or reimbursement amounts by third-parties; intellectual property protection and potential infringement claims; maintaining compliance with government regulations and obtaining necessary government approvals for new indications; product liability claims and potential litigation; reliance on single suppliers and manufacturers for certain components; the accuracy of management's estimates of future expenses and sales; the results of the previously disclosed governmental inquiries; the potential identification of material weaknesses in our internal controls over financial reporting; risks and costs associated with such governmental inquiries and any litigation relating thereto, and practices and other risks detailed from time to time in our filings with the Securities and Exchange Commission (SEC). For a detailed discussion of these and other cautionary statements, please refer to our most recent filings with the SEC, including our Annual Report on Form 10-K for the fiscal year ended April 24, 2009, and Quarterly Reports on Form 10-Q for the fiscal quarters ended July 23, 2009, October 23, 2009, and January 22, 2010.
Contact information Greg Browne, CFO Cyberonics, Inc. 100 Cyberonics Blvd. Houston, TX 77058 Main: (281) 228-7262 Fax: (281) 218-9332 firstname.lastname@example.com
SOURCE Cyberonics, Inc.


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|« Back to Article
UT guard Kabongo opts for NBA draft
Associated Press | April 12, 2013 | Updated: April 12, 2013 10:44pm
Photo By Brody Schmidt/FRE
Myck Kabongo is leaving Austin after his sophomore season.
AUSTIN - Texas guard Myck Kabongo said Friday he is skipping his final two seasons to enter the NBA draft.
Kabongo played just the final 11 games of his sophomore season with the Longhorns after a 23-game NCAA suspension for accepting airfare and personal training instruction and lying about it to school officials. He led the team in scoring (14.6 points per game), assists (5.5) and steals (2.0) and was named team MVP despite his shortened season.
Texas finished 16-18 and missed the NCAA Tournament for the first time since 1998.
In two seasons, the 6-1 Kabongo started 45 games, averaging 10.8 points and 5.3 assists per game.

subset: commoncrawl


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For nearly three decades, Beaver motorcoaches have represented the very best luxury and comfort the recreational vehicle industry has to offer. From meager beginnings in a small central Oregon town, Beaver has cultivated a reputation for breathtaking woodwork, supple fabrics, plush furnishings and awesome power and performance. Those recreational vehicle enthusiasts who want to enjoy their adventures and still be cradled in comfort have always looked toward Beaver to deliver just that.View all Beaver RVs Models
If you currently own an RV, the "RV Living Owner's Guide" is full of information to help you enjoy your new lifestyle! Download the Free Owner's Guide
Trusted buyers. Only $19.95 to list. Place your RV for sale here!


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Community Events
Community Events Hotline: (812) 349-3754
For weather-related or other cancellations of concerts or other community events.
Community Events Staff
- Paula McDevitt, Recreation Programs Director
- Becky Barrick-Higgins, Community Events Manager
- Bill Ream, Community Events Coordinator
- Greg Jacobs, Community Events Coordinator
- Lynsie Haag, Program Specialist
Quick Links
- #itsinthepark
- A Fair of the Arts
- Bloomington Bikes Month
- Concerts, Movies, and Plays
- Fourth of July Parade
- Junk in the Trunk
- Yappy Hours - dog-related programs at Ferguson Dog Park
Active Living Coalition Health Fair
Saturday, May 30 · 9 a.m.-noon
Showers Plaza, 401 N. Morton St.
Admission is free
Get up, get out, and get active at the Active Living Coalition's annual Health Fair! Visit more than 20 health- and wellness-related booths, watch exercise demonstrations, take home some special giveaways, and gather all the info you need to live a healthy lifestyle! The Active Living Coalition Health Fair takes lace next to the Bloomington Community Farmers' Market, the ideal place to purchase fresh, healthy, locally grown food.
For more information contact Alison Miller, Health and Wellness Coordinator, at 812-349-3771 or email@example.com
Sustaining Nature and Your Land Day
Native plants are required to support local ecosystems, but invasive plants are rapidly crowding them out. Sustaining Nature and Your Land (SNAYL) Day provides information about how you can encourage the growth of beautiful, life-supporting native plants on your property while controlling the invasive plants that threaten them. Lunch will be available for purchase. For all ages. Instructor: Steve Cotter
Sa 6/6 · 10 a.m.-3 p.m.
Harmony School, 909 E. 2nd St.
Touch A Truck
Wednesday, June 10 · 10 a.m.-2 p.m.
Twin Lakes Sports Park parking lot, 2350 W. Bloomfield Rd. Parking is available at the Twin Lakes Recreation Center, 1700 W. Bloomfield Rd.
Admission $1 per person.
Big rigs or bust at the 15th annual Touch a Truck! Get up close and personal with fire trucks, ambulances, buses, bucket trucks, and more. Explore and learn about the inner and outer workings of all your favorite vehicles.
For more information contact Lynsie Haag, Community Events Specialist, at 812-349-3718 or firstname.lastname@example.com
For weather-related cancellations, call the Community Events Hotline at 812-349-3754. Rain date is Thursday, June 11.
Bug Fest
Learn all about amazing insects at Bloomington's third annual Bug Fest! Go on an insect safari, handle cool insects, make a craft, and participate in a mealworm race or cricket spitting contest. There will be speakers and information booths on a variety of buggy topics. This event is a collaboration of Bloomington Parks and Recreation, Monroe County Parks and Recreation, The WonderLab Museum, Purdue Extension office, and Hilltop Gardens at Indiana University. For all ages.
Sa 6/27 · 10 a.m.-2 p.m.
Hilltop Garden at Indiana University, 2367 E. 10th St.
Messy Mania
Tuesday, July 14 · 9 a.m.-noon
Bryan Park - Henderson and North Shelters
Admission $5 per child.
Kids get crazy with their hands when we let them dig into all kinds of messy mediums, with no worries about creating chaos in the house. These hands-on activities will delight every youngster who loves to squish, splatter, and fling! Let us take care of the prep time and cleanup, while you and your child experience a morning of head-to-toe, ooey gooey good times! For ages 1-8 yrs. w/parent.
For more information contact Lynsie Haag at 812-349-3718 or via e-mail at firstname.lastname@example.com.
|Event Sponsor
Spotlight Webpages in Parks & Recreation Community Events
Bloomington Bikes Month
Celebrate May with several events that will get you rolling!
Information in Parks & Recreation Community Events
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Redskins' Crawford injures knee
LANDOVER, Md. (AP)
Washington Redskins punt returner Richard Crawford is out for the season with a left knee injury.
- Steelers WR Burress out for season
- Season over for injured Saints duo
- Packers LT Bulaga opts for surgery
- Second Eagles wideout tears ACL
- Chargers WR Alexander tears ACL
- 49ers CB Culliver tears ACL
- Seahawks' Harvin needs surgery
- Eagles WR Maclin tears ACL
- Ravens TE Pitta out for season
- Photos: NFL major injuries
Coach Mike Shanahan said Crawford injured at least one ligament and possibly a second on a 3-yard punt return in the first quarter of Saturday's 30-7 win over the Buffalo Bills.
Crawford was a seventh-round draft pick as a defensive back last year and won the job as punt returner in midseason. He returned eight punts for 156 yards in 2012, including a 64-run return that set up the winning field goal in an overtime win over the Baltimore Ravens.
Rookie Chris Thompson took over the punt return duties after Crawford left Saturday's game.
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NFL Headlines
NFL Insiders: Dolphins name Dennis Hickey new general manager
Carroll: Seahawks CB Richard Sherman sorry about postgame rant
Browns to interview Bills' Pettine with Broncos' Gase out of running
NFL talking to 49ers about sideline hit vs Seahawks in NFC title game
Falcons hire former Chiefs GM Pioli as assistant general manager


text:
- Use the cinnamon scented spray on mattresses, carpets, upholstery, curtains and other fabrics.
- Vacuuming is not necessary but recommended.
- Contains 16-fluid ounces.
We're featuring shopping recommendations just for you!
You'll find trending products our customers are excited about, and suggestions based on items you've recently viewed and purchased.
Shop school merchandise, find local stores and schedule pickup or delivery for your stuff!
Pick out what you want, and invite family and friends to pick up the tab.
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Product name goes here.
Please enter the address, city, state where you will be starting.
Help is always available at 1-800-GO-BEYOND®
(1-800-462-3966). Please view our Returns Policy if you aren't satisfied with your order.
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Refund Schedule
***A & B semester refunds begin within 14 days of the first day of class and are issued every Tuesday and Thursday until mid-term. After mid-term, refunds are issued only on Tuesdays. This schedule may change without notice at the discretion of the College.
***C Session refund schedule will be posted at a later date.
Payment Dates
Summer 2015 Advanced Registration Payment Deadline- May 5, 2015 by 5 PM
Summer 2015 Late Registration Payment Deadline- May 21, 2015 by 5 PM


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Myself and husband Adrian are Owners and Managers. We are very dedicated to our Customers and go out of our way to ensure each...More information +
Myself and husband Adrian are Owners and Managers. We are very dedicated to our Customers and go out of our way to ensure each of their stays are special.Adrian and myself live in Gloucester and can provide our guests with a wealth of local knowledge, ensuring our visitors see the best Gloucester and Barrington Tops have to offer.We reception, clean, maintain, cook are tour operators and when the work is all done we enjoy a beer with some of the guests. It's great to be in the accommodation / tour business as we meet fun and interesting people all the time.
We hope you will visit us one day soon.
Your hosts Bev and Adrian P.
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3 BR / 2 BA / Sleeps 6
Left on Feb 01, 2012 for a stay in December 2011
My partner and I stayed for 2 nights. From the moment you arrived you just felt relaxed. The accommodation was very comfortable. The bedrooms and lounge room were very spacious. We had dinner at Monte Kia Ora which was a short walk from the house and the food was really good. We spent some time with the owners Bev and Adrian who were great and very helpful. We are already planning our next trip …
2 BR / 1 BA / Sleeps 4
Left on Feb 13, 2012 for a stay in January 2012
We loved the spacious house and magnificent views. We were made feel very welcome and 'at home'. The house was beautifully furnished and the beds very comfortable. It exceeded our expectations and would love to visit again.


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Sen. Mark Begich appears to be the most affluent among the Alaska congressional delegation, with a net worth estimated by the Center for Responsive Politics at $2.3 million.
But Begich is a pauper compared to many of his colleagues, ranking 174th out of the 535 members of Congress in estimated net worth. Alaska Sen. Lisa Murkowski ranked 205th on the list, with an estimate of $1.7 million.
Alaska Rep. Don Young's estimated net worth of $840,000 put him down at 279th among the members of Congress.
It's a tough crowd to compete in, with 47 percent of Congress figured to be millionaires. California Rep. Darrell Issa tops the list with a net worth pegged at $448.1 million. Seven others each have a net worth of more than $100 million.
The numbers are just estimates because members of Congress are required to disclose assets and liabilities only in broad ranges.
The Center for Responsive Politics, a watchdog group, recently came up with the estimates by averaging each member of Congress' lowest and highest possible net worth. The analysis is based on the most recently available disclosures, covering 2010.
The numbers include a spouse's assets but the disclosures don't have to include the value of lawmakers' personal residences or any mortgages owed on them, The Begich and Murkowski families both own Washington, D.C., row houses that are valued at more than $800,000, for example, and that's not included in the disclosure reports.
The disclosures also don't require lawmakers to list their annual $174,000 congressional salaries. They do list stocks and other investments.
Members of Congress are required to file the disclosure forms every year to give the public a glimpse at their investments, personal wealth and potential conflicts of interest. The next forms, covering 2011, will be released in June.
Begich reported assets in Nevada, where he's part owner of the Carson Hot Springs Resort. The resort's website says that in 1999 "a group of investors headed by Mark Begich of Anchorage, Alaska, purchased the springs with the goal of bringing it back to its glory days." It's a casual place with a big outdoor pool for $10 a day and little private pools for extra charges.
The Reno Gazette-Journal ran a story after Begich beat Sen. Ted Stevens in 2008, describing how Begich and his wife, Deborah Bonito, came across the hot springs while veering from a road trip through California and decided to go ahead and buy it.
Other assets listed by Begich included his wife's interests in the Kobuk Coffee Co. store in downtown Anchorage -- which a pickup and its allegedly drunken driver smashed into this spring -- and Sourdough Mercantile, a gift shop at the airport.
Begich and Bonito are paying off commercial loans in Anchorage and Nevada on properties and, since the exact value of such liabilities is not required to be disclosed, his net worth could be a lot less or more than estimated.
Among Begich's reported stocks were between $50,000 and $100,000 worth of stock in Keryx Biopharmaceuticals, which is testing a colorectal cancer drug. He listed his wife's investments, including between $15,000 and $50,000 each in stocks including Kraft, KeyCorp, Regal Entertainment Group, Excel Energy and the National Bank of Greece.
Murkowski's financial disclosure form included shares worth between $15,000 and $50,000 in Wells Fargo bank. Murkowski reported $272,000 from the sale of a building on E Street in Anchorage that used to house her husband Verne Martell's pasta company, as well as $10,000 in continuing payments from the 2010 sale of Alaska Pasta Co.
Young, Alaska's lone member of the U.S. House since 1973, reported between $100,000 and $250,000 in the Putnam Fund for Growth, an investment fund.
He also listed more than $100,000 in an account with the congressional credit union and retirement accounts of between $65,000 and $150,000. Young reported $5,329 as his state pension from his time as a teacher and in the state Legislature.
Reach Sean Cockerham at email@example.com or 257-4344.
By SEAN COCKERHAM
Anchorage Daily News


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
43 year old woman | Orchard Park, NY, USA | Seeking men 38-50 within 50 miles
Looking for someone to enjoy what life has to offer.
Hi - thanks for stopping by! My friends at work call me "smiley" because I'm always smiling - which I suppose is a good thing:-) That and laughter are very important to making every day a good day. I consider myself a "glass half full" kind of person and always look for the positive in every situation. If you agree with this kind of attitude, then we'll probably get a long great! I work for the owners of a local auto dealership and LOVE my job:-) With that being said, my job is very unqiue and every day is different, which can be a lot of fun. I enjoy meeting and helping people - and I've made lots of friends working in this line of business. But I'm looking for that special person to share my life with. I come from a terrific family and have three great kids. I've been told I'm very easy to talk to and put people at ease - so if interested let me know:-) Looking forward to meeting you! Mollie PS- My hair is recently been returned to dark chocolate brown - the blond was fun but the dark seems to be more me:-) New pics forthcoming.....
Camping , Coffee and conversation , Business networking , Cooking , Dining out , Gardening/Landscaping , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing sports , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Aerobics, Auto racing / Motorcross, Baseball, Bowling, Dancing, Football, Golf, Hockey, Inline skating, Running, Skiing, Soccer, Swimming, Tennis / Racquet sports, VolleyBall, Walking / Hiking, Weights / Machines, Yoga
I exercise 1-2 times per week.
I have Cats
I like Dogs, Fish, Horses
I am enjoying having my first kitten. Her name is Fiona Rose and she's lots of fun. She doesn't shed which is good because I like my townhouse very tidy:-) I've always been a dog person but Fiona is quickly changing my mind!
Middle of the Road
Vacationed recently in Virginia Beach, VA - love the beach! Sherkston, CA is great too! Fav Restaurants include, David's, Mangia's, Siena, Chop House, Shogun etc. A little bit of everything!
A good glass of wine, good company with light conversation, a great goodnight kiss:-) etc, etc, etc..........
I enjoy spending time with my family and friends at our family beach house. Stopping out for a nice dinner and glass of wine is casual fun too. And now that the weather is getting nice - I love my convertible!
Reading the Hunger Games Series right now.............
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'6" (167cms)
|5'5" (165cms) to 7'6" (228cms)
|Body type:
|Slender, About average, Athletic and toned, A few extra pounds
|No preference
|Dark brown
|No preference
|No Way
|No Way, Occasionally, Yes, but trying to quit
|Social Drinker
|Never, Social Drinker
|Sales / Marketing
|Administrative / Secretarial, Executive / Management, Financial / Accounting / Real Estate, Labor / Construction, Legal, Medical / Dental / Veterinary / Fitness, Political / Govt / Civil Service / Military, Retail / Food services, Sales / Marketing, Self-Employed / Entrepreneur, Education / Teacher / Professor, Technical / Science / Computers / Engineering, Travel / Hospitality / Transportation, Nonprofit / Volunteer / Activist, Law enforcement / Security / Military
Work for the owners of a local Auto Dealer as their Social Media/Marketing Manager. Have appeared on commericals airing on local TV channels.
|I'll tell you later
|$35,001 to $50,000, $50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000
|Never Married, Widow / Widower, Divorced
|Have kids:
|Yes, and they sometimes live at home (3)
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|No, but it's OK if my partner has kids
|Not sure, Probably not, No, but it's OK if my partner has kids
|White / Caucasian
|No preference
Irish, German and Croatian
|Christian / Catholic
|Christian / Catholic
|I'll tell you later
|No preference


text:
Crash injuring three workers just 'unavoidable accident'
Young Professionals
Economic Development
Liberal cabinet minister says his party campaigned on dealing with...
Curry, Warriors hold off Harden, Rockets 99-98 to take 2-0 lead in Western...
The Spectator's Steve Milton muses about city's new Tim Hortons Field.
Michael Caine insists he's "never been tempted to stray" from his...
The federal NDP will reinstate door-to-door delivery and get rid of super...
Yachetti, Lanza & Restivo LLP in Hamilton, Ontario understands the...
TORONTO Health Canada has come up with a temporary solution to eliminate a jurisdictional grey area that may have contributed to more than 1,200 patients receiving diluted chemotherapy drugs, The Canadian Press has learned.
Officials with the federal health agency will discuss the proposal in a conference call Friday with top health bureaucrats from all the provinces and territories.
"It will clarify that every facility needs to be clearly identified as being under oversight of one of the jurisdictions, be it provincial or federal or pharmacists and so on," a government source said.
The goal is to close the gap between provincial and federal responsibilities over facilities that mix chemotherapy drugs for hospitals, like the one that provided the watered-down drugs to five hospitals in Ontario and New Brunswick.
"The proposal would ensure that every facility would fall under a clear oversight — be it federal or provincial — and obviously that's important for patient care," the source said.
Both the Ontario and federal governments have acknowledged that they don't know how many companies like Marchese Hospital Solutions are mixing cancer drugs for hospitals with no oversight.
Too much saline was added to the bags containing cyclophosphamide and gemcitabine, in effect watering down the prescribed drug concentrations by up to 20 per cent. Some patients were taking the drugs for as long as a year.
Health Minister Leona Aglukkaq and Ontario Health Minister Deb Matthews spoke over the phone Thursday about the drug scare, which has raised red flags about the lack of oversight.
Marchese Hospital Solutions fell into a jurisdictional grey area, with Health Canada and the Ontario College of Pharmacists unable to agree on which was responsible for the facility.
Hospitals are responsible for the purchase and security of their drugs. Health Canada regulates and inspects drug manufacturers, while the college is responsible for pharmacists in Ontario, including those who may have been working independently for the company.
But Marchese Hospital Solutions, which was federally incorporated, wasn't considered to be a pharmacy or a drug manufacturer.
The diluted drugs were only discovered when a pharmacy technician at a Peterborough hospital that had just switched over to Marchese noticed the bags were overfilled.
Marchese has said its products weren't defective, and suggested that the problem wasn't how the drugs were prepared but how they were administered at the hospitals.
Matthews has said that she wants to work collaboratively with the federal government to close that gap and she's willing to give the college the authority to oversee companies like Marchese.
But behind closed doors the minister has said she wants the federal government to oversee facilities like Marchese, the source said. But there are major risks to that, since it's still unclear how many there are in Canada.
Before issuing a manufacturing licence, Health Canada would have to stop production at all these facilities while their final products underwent clinical trials.
"You could inadvertently trigger a massive drug shortage across the province," the source said.
"If this is left as a federal-only solution, then it's going to have a real adverse impact on patient care."
Agluqqak is frustrated because companies like Marchese were created under the province's watch as hospitals signed contracts for compounding chemo drugs, the source said.
It's created a market where, to keep costs down, these companies are compounding drugs on a larger scale and selling it to hospitals.
The Canadian Press
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Sylvia Mathews Burwell
From Ballotpedia
|Sylvia Mathews Burwell
|Director of the Office of Management and Budget
|Elections and appointments
|April 24, 2013
|Appointed by
|Barack Obama
|Term limits
|Harvard University, Oxford University
|Date of birth
|June 1965
|Place of birth
|Hinton, West Virginia
|Office website
She previously served during both the Obama and Clinton administrations in the Treasury Department, Office of Management and Budget and on President Clinton's staff.[2]
Mathews Burwell was born in Hinton, West Virginia. She attended Harvard University and was a Rhodes Scholar at Oxford University before beginning her political career.
Below is an abbreviated outline of Mathews Burwell's academic, professional and political career:[2][3]
- 1988-1990: Rhodes Scholar at Oxford University
- 1990-1992: Associate at McKinsey & Company
- 1992: Member of the Clinton presidential campaign
- 1993-1995: Staff Director of the National Economic Council
- 1995-1997: Chief of Staff for Treasury Secretary Robert Rubin
- 1997-1998: Deputy Chief of Staff in the White House
- 1998-2001: Deputy Director of the OMB under Jack Lew
- 2001-2012: COO then President of the Global Development Program at the Bill & Melinda Gates Foundation
- 2012-2013: President of the Walmart Foundation
- 2013-Present: Director of the Office of Management and Budget
Confirmation vote
Mathews Burwell was confirmed by the Senate on April 24, 2013, by a vote of 96-0.Cite error: Closing
</ref> missing for
<ref> tag
Recent news
This section displays the most recent stories in a Google news search for the term Sylvia + Mathews + Burwell + Management + Budget
- All stories may not be relevant to this page due to the nature of the search engine.
Sylvia Mathews Burwell News Feed
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External links
- Biographies:
- ↑ GovTrack, "On the Nomination: Sylvia Mathews Burwell," April 24, 2013
- ↑ 2.0 2.1 2.2 Washington Post, "Sylvia Mathews Burwell: Six things to know about the new White House budget director," March 3, 2013
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs named
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Season 7 Feedback
View Single Post
Lt. Commander
Join Date: Jun 2012
Posts: 171
# 1
Season 7 Feedback
So I've wallowed through the season 7 mire long enough to max out one character on the reputation system. I've done most everything in Tau Dewa/New Romulus at least once. And with the balance adjustments put in place already, presumably this is season 7 as the Devs want it. That makes it a good time to give feedback regarding all of it.
TLDR: S7 is bad, too grindy, too much inventory trash, too expensive.
For those of us that can read, lets start with the reputation system. While I think the idea of the reputation system is a good one, to avoid the situation of doing STFs forever and never getting the drop you want or need, its insanely expensive and utterly unfun.
I spent between 4-5m credits on consumables and commodities getting to tier 5, all of them bought as cheaply as possible (IE not from the market). I can say quite certainly that drops in STFs do not cover the cost. You'll get the marks far faster than the credits, leaving you needing to grind credits somewhere else.
Now before you say play the market for credits, which one can do, it is avoiding reality. The reputation system siphons out a LOT of credits. If you do not earn them somewhere else from drops or missions, etc, you are only lowering the credit supply, which causes the market to falter as people have less cash to buy things. I'm not going to go into market economics though. But for me, I'm that much poorer, and much less likely to buy things on the market because the reputation grind is so expensive.
Now, Tour the galaxy is supposedly a good credit earner, but I've yet to find time to do that since it has been implemented, and since it is on a rare cycle. So for me, I lose a lot of credits doing this system with no clear way to make them back again. This is a major stumbling block to the system for casual players like myself who don't have time to grind endlessly for credits just to grind more for reputation. But my rep grind is over, right? No.
The next point to make is the fact I have 10 characters at VA/LG. I have finished one grind, and have 9 more to go, most in various stages of tier 1/2. Do I NEED to do it? No, yet, that same mentality is what has screwed me over in season 7.
I didn't NEED to push hard to get all those characters borg/omega/etc gear before season 7. I could run a few STFs now and then and hope for the best, save up my EDCs for when I wanted to buy a piece (and pre season 5, it only took 1 STF run to get a borg set piece!).
Now season 7 comes around and I got screwed hard. Most of my characters that could have had the set parts I wanted, don't have them because I didn't push harder earlier. So now I feel the NEED to grind, because who knows what will be done to the system to make it even harder in a couple more seasons? But I have no desire to grind at all, and burnout comes fast with this system. This ends up making me play the bare minimum to get a few reputation projects going and then log off and do something fun.
Probably most frustrating is that as a gold subscriber, I get zero anything in this system. My extra characters and slots mean I suffer a lot more than F2P players who maybe have 2-3 characters total. Account based reputation doesn't make much sense, however giving gold subs a discount or partial refund on mark/commodity costs would make a lot more sense and give real value to the virtually nil value to subs these days.
Whats more, this system makes me very averse to ever starting a new character because of the impending tedious grind they will have to do to get end gear. This costs Cryptic $$. Why? Personally, I make a character to enjoy a new playstyle. Eng/cruiser, sci/escort, etc. and with all the ships out there you can get some pretty interesting combos. But if I don't want to start a new character because of the rep grind, I don't have any interest in new ships that would offer a new playstyle. This means I'm not buying zen and, it means I'm not selling my dilithium for zen, because I have nothing to buy with it. And why not just try new ships on an old character? Because then I would need to respec, out of another playstyle I liked.
This grind is just daunting, and some of the worse parts of it are the mark costs versus rewards. Elite STFs give about 3x more marks than normal STFs, despite taking maybe 30 minutes vs 20. This, for me, has completely killed the desire to do normal STFs, and because elite is frustrating with the nonsensical one shots, I always avoided them in the past. So now I have to do something I don't want to do because its just dumb to do any less.
Additionally, the projects in the reputation system have absurd costs. 500 marks for one part of the mk X borg set! The legacy set is mk XI, and you could get that with one run of a full STF, or 5 runs of a season 5 normal STF. But to run normals for that now, you're going to end up running no less than 25 STFs, and get worse gear, while you should have just saved those marks up for the mk XI set, or finish the rep grind with those marks and then work on mk XII. Considering there is no real reason to ever buy the mk X set, it should cost maybe 50 marks per part.
The mk XI set, being the legacy set, is also vastly overpriced at the old standards, especially given that you have to do more STFs to get the reputation to even begin working on getting marks for the set itself.
That said, this is actually one point the omega rep system has over the romulan system. The romulan mark grind is atrociously painful and slow compared to doing STFs for omega marks. The comparative activities for R-marks like the azure nebula rescue and mine trap give out a fraction of marks that the STFs do, and fleet marks I care nothing about. The daily is repetitive and time consuming, and the New romulus missions are no better. Epohhs can die in a fire, and don't work out to be much better for time invested. Yes they make you feel better to get one big lump sum for it, but it takes many days to get there.
This much slower, more tedious grind for R-marks is extra painful when the items and projects cost exactly the same as their omega counterparts, and are not better or more valuable.
And on the subject of tedium, the reputation grind is horrible. Log in, claim rewards, fill in the sliders, oops, wait, I need more stem bolts. Run out to Regulus, buy a few hundred of them from a freighter, and energy cells or whatever else, then go log out next to a ground consumable vendor so the next few days I don't have to do this all over again. Maybe run an STF or something to get some marks. Now consider trying to do this every day on 10 characters. I don't either, 2-3 is enough for one day.
Why not buy several thousand commodities at once? Stacking limits and inventory space. I have to keep going back and forth to various vendors to get the silly projects going because I can't possibly get enough space for it all. This is a point in itself.
Season 7 has seriously too much inventory garbage with the commodities and consumables for rep grinding and the dozen different collectibles on New Romulus for the various missions, like rock and flower and radiation analyses, epohh garbage, etc. Why? I mean why are there all these silly things to take up inventory space when they are nothing but currencies? I've never had enough inventory space in this game, and season 7 just makes it worse. Buy more? No, not with 10 characters and no account inventory option.
So lets change the subject. Dilithium. Yes its been gone over before, but I'm no more happy with it now. Firstly, I'm not in a fleet. I could not care less about fleet requirements or fleet ships. However, it is not lost on me that dilithium is far harder to get in season 7. A normal STF grants a third of what it used to give. I don't know what elite STFs used to give, but presumably that is a third of what it used to give as well. I also think that EDC vs mark/processor dilithium exchange favors the old EDC turn in by a fair margin.
Yes now I can do fleet actions for dilithium. Great! Except it takes the same time as an STF and doesn't give much else as a reward, especially considering the ridiculous amount of marks I need for the reputation system.
Changing the foundry daily is fine with me. The system isn't that good as it is now, but definitely it is more in line with what it should be. Of course it did have a major impact in the dilithium supply.
Oh but now I need dilithium for all my reputation equipment. Great. Yes the reputation project rewards are somewhat helpful, but overall, its extra cost for things that didn't used to cost dilithium at all. The costs at least seem mostly in line with other purple items, nevermind how overpriced it all is, but relatively, at least it seems fair.
Still, I'm a casual these days. I don't meet my daily refinement cap, and never have. Making it harder to get, making my time less valuable and less rewarding is not at all appreciated. I'm not hurting for dilithium either. I still have gobs from the conversion, and plenty of contraband. But I do not like the system as I see it when I consider that if I didn't have all that dilithium and all the equipment from pre dilithium days, it would be exceedingly painful to get it all again.
However, the DOFF grinder changes really tick me off. The upgrinder is now useless. It serves no purpose because the cost is exceedingly high and you still have no control over the reward you get. It means I end up swimming in white/green doffs I don't want and can't get rid of. Its why my mail is full of doffs that didn't sell on the exchange. I did want a mostly Orion DOFF crew for my Orion captain, but that is totally impossible to work towards now. I did want to build up a good purple resolve set for the console assignment, but that is impossible now.
Are there other ways to get purple doffs, resolve doffs, even get rid of white/green doffs? Yes, and none of them are reasonable in terms of time spent finding/unlocking them, availability, and rarity. Most of the gamma quadrant exchange chains I have yet to complete because I never find them when they are active. Do I have massive amounts of purples for the months and months the grinder was worth it? Not even close. I earned less purples from the doff grinder than I have fingers on one hand. That is why it was a good option for me, because I don't have that kind of time to spend on flying all over the galaxy, every. single. day, because then I can't get anything else done.
So in conclusion, season 7 seems aimed squarely at the F2P crowd who doesn't spend money and accepts grind in exchange for "FREE". For those of us with less time and want value for our time and money spent, we get less than ever. Its no surprise I spend less and less time in this game and spend my money elsewhere.
It could all be improved, though. The DOFF grinder could change to let you pick the type of DOFF you get, or put the costs back to where they were. The relative value of dilithium has changed significantly in season 7, so the old costs are still effectively more expensive than ever.
Commodities and consumables could stack to 1000 at least, or you could lower the input required, considering how many credits they eat up.
Mk X and XI reputation projects should have their mark costs slashed dramatically. They exist for no other purpose than to be a red herring and get people to waste marks and dilithium.
Normal STFs and most romulan missions should reward more marks. Of course elite STFs still need to fix the phantom one shot non-crit torpedoes.
Gold accounts should get a discount, either slash all the input requirements for reputation projects by 25% or give a refund of the same after inputting the required amount. Alternatively gold could earn 25% more credits/dilithium/marks as a standard feature, and then of course you can sell timed boosts for such in the zen store for free players.
And to close, if you didn't read all of this, I don't care about your opinion about my opinion.


text: Andrew John Jennings was recently engaged to Dana Adele Di- Giando, whose parents – Julio DiGiando and Charlene and Ned Gamble – all hail from Jamestown. Andrew is the son of Renie and Bob Sullivan of Newport, and John Jennings Jr. of Tiverton. Dana is employed at Harken Yacht Equipment and Andrew works for Kirby Perkins-Construction. A May 2012 is planned in Newport with a garden reception to follow in Jamestown.


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Letters to the Editor
Regarding Phil Hughes' article in the December issue of LJ, please help push further development of Arena. Netscape is huge, slow, and our only option. I now use Lynx for almost all my browsing because Netscape is so slow on my system. Arena runs well, but cannot handle forms, one of the most functional features of a web browser. Like many people, I am not interested in background patterns and enhanced fonts. I want easy access to information, which I am unable to get with Netscape or the current Arena.
—Peter McArthur firstname.lastname@example.com
Linux Journal has a sister publication called WEBsmith™, and its editor, Jon Gross, was recently involved in a World Wide Web conference. We asked him to respond:
I (and many others) agree with your summation of the status of the browser selection available at this point. In December, I was at the 4th International World Wide Web conference in Boston, and a group of us started talking, and decided it was time to start a Free Browser project, modeled on the Linux community, to address exactly this problem. We are putting a mildly cohesive framework together before "going public" but your input is certainly appreciated. The Linux community has much to offer this project, and I think we can definitely build a better mousetrap. A mailing list has been set up. See www.base.com/gordoni/web/www4-bof.html for more information.
—Websmith Magazine Editor, Jonathan Gross
"The chmod Command" by Eric Goebelbecker (LJ #21) was an excellent introduction to the sometimes counterintuitive file and directory permissions of Unix-like operating systems. Near the end, however, there is a misstatement concerning the "sticky bit". This bit actually has a very important, though obscure, use on Linux systems.
The sticky bit got its name on early Unix systems in the days before demand-paged virtual memory. If the sticky bit of an executable file was set, after the program exited a copy of its text segment was saved in the system's swap area, i.e., it would "stick around" for the next use. This feature was used to make frequently-run programs load a little bit faster. This meaning of the sticky bit is no longer particularly relevant.
Although it is not a part of the POSIX specification, recent System V and Berkeley Unix systems defined a new meaning for the sticky bit. If a directory's sticky bit is set, a file in the directory may be deleted only by the file's owner, by the directory's owner, or by root. This provides an additional measure of security for directories such as /tmp. Linux, of course, supports this useful feature. For example, on my system:
$ ls -ld /tmp drwxrwxrwt 3 root root 1024 Jan 1 09:49 /tmp $ ls -l /tmp -rw------- 1 roman users 0 Jan 1 09:49 bar -rw------- 1 root root 0 Jan 1 09:47 foo $ rm /tmp/bar $ rm /tmp/foo rm: /tmp/foo: Operation not permitted
Without the sticky bit, I would have been able to remove root's file from /tmp.
—Bill Roman email@example.com
Mea Culpa. Thank you for pointing out that mistake. It should never have passed through editing.
I read your article on LISP-Stat last August with much interest, and have just got around to trying it out. One inconsistency: the article claims that the "dld" library is essential. This is not true; if you build Lisp-Stat from scratch, it will use the now-standard "dlopen" method for dynamic loading (based on the ld.so library) if it is present. In fact, "dld" no longer seems to work with current "a.out" style static libraries, let alone ELF libraries.
I compiled the thing for ELF using gcc 2.7.0 and everything worked just great. The compile time is rather long (about an hour on a 486-33 with 20M memory), especially since a lot of the code is in LISP. All of the book examples worked perfectly. A marvellous way to review long-forgotten stats material.
You are doing an excellent job at presenting intriguing applications for Linux. Please keep up the great work!
—Rod Hallsworth firstname.lastname@example.com
Tools and Technologies for Scale and Reliability
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|Non-Linux FOSS: Vienna, Not Just for Sausages
|Jun 02, 2015
|June 2015 Issue of Linux Journal: Networking
|Jun 01, 2015
|June 2015 Video Preview
|Jun 01, 2015
|My Humble Little Game Collection
|May 28, 2015
|New Linux Based OS Brings Internet of Things Closer to Reality
|May 27, 2015
|Non-Linux FOSS: All the Bitcoin, None of the Bloat
|May 26, 2015
- Non-Linux FOSS: Vienna, Not Just for Sausages
- June 2015 Issue of Linux Journal: Networking
- New Linux Based OS Brings Internet of Things Closer to Reality
- Using Hiera with Puppet
- Dr Hjkl on the Command Line
- Initializing and Managing Services in Linux: Past, Present and Future
- My Humble Little Game Collection
- Infinite BusyBox with systemd
- Goodbye, Pi. Hello, C.H.I.P.
- Gartner Dubs DivvyCloud Cool Cloud Management Vendor


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Lindorff International solves 3 out of 4 international cases
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text:
Kurt Busch spent time at the road course in Texas where he took laps in a V8 Supercar normally driven by James Courtney who got to drive the Furniture Row Racing Chevrolet.
Ryan Newman hoping for 2013 season to bloom at richmond
Still winless, but still in the points lead
ARCA to IndyCar, Marquez to Mick Schumacher.
I may be in the minority with my friend Ryan Hyatt, but here are my thoughts on what we should do about the fight that ensued after the checkered flag flew at Richmond last weekend...
Reports from Chicagoland hint at potential Chase shakeup.
Bowyer and Larson 'downright desperate.'
Truex has been removed from the Chase, with Newman put back in after NASCAR hands down penalties.
The aftermath of the NASCAR Sprint Cup race in Richmond has bitten Michael Waltrip Racing with the news that NAPA will leave at end of the season.
NASCAR has issued penalties to Marcos Ambrose and Casey Mears following their altercation at Richmond last weekend.
Marcos Ambrose and team owner Richard Petty talk about the fight that led to NASCAR fining Marcos $25,000 and placing him on probation for one month.
It was an exciting night under the lights at Richmond in a race that saw cars bursting into flames, drivers going three wide for the lead in the closing laps, and there were even a few punches thrown!
One of the primary long-time sponsors for Michael Waltrip and his NASCAR team apparently is considering withdrawing.
NASCAR president Mike Helton replies to questions on the penalties handed out to the Michael Waltrip Racing team following the Richmond race. NASCAR vice-president of competition Robin Pemberton was also present.
Nine of the first 26 regular-season races have been run, and Stewart-Haas Racing and Team Penske have recorded three victories each.
The top stories as NASCAR's best head to Richmond International Raceway...
Was Joey Logano's move ahead of David Gilliland in Richmond set-up between the two Ford teams?
Danica Patrick searching for more short-track success
Washington Redskins QB Robert Griffin III ended up as the pace car driver for tonight's NASCAR Sprint Cup race at Richmond because of a series of tweets instigated by Dale Earnhardt Jr.
As we near 2014, we are looking at the top 20 moments of this past season, and in the number 5 spot is 'Spingate.'
More on the fallout from the Richmond race with changes effective immediately, and some to come later.
Battles ill-handling car to 25th-place finish
Michael Waltrip Racing's Clint Bowyer kept mum about the now famous spin at Richmond.
Ambrose has two career Sprint Cup victories, both at the Watkins Glen International road course.


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Season all sides of the beef with a fair amount of salt and pepper. In a large Dutch oven or other heavy pot that has a tight cover; heat 2 tablespoons of the oil over moderately high heat. Brown the meat on all sides, taking the time to get a nice crust on the outside. Pour in the tomatoes and the water. Scatter the vegetables and herbs around the pot roast, season with salt and pepper; and drizzle with the remaining tablespoon of oil. Cover the pot and reduce the heat to low. Braise for about 3 hours, basting every 30 minutes with the pan juices, until the beef is fork tender.
Slice the pot roast and arrange on platter surrounded by the vegetables. Serve with the pot juices.
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Chardonnay, Sauvignon Blanc and Pinot Noir are the best wines to pair with Pot Roast with Vegetables.
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Recipe by Tyler Florence from Tyler's Ultimate
Recipe by Tyler Florence from Tyler's Ultimate


text: Take a pan and heat over medium high. Melt butter. Add the leeks and sugar. Saute till translucent for about 5 minutes. Add salt and pepper and sauté. Add lettuce, parsley and peas. Add 1 cup chicken stock. Cover and cook for approximately 5 minutes (till peas are nice and tender). Add remaining chicken stock and boil. Puree the soup well. Take another pot and pour the strained soup liquid. Serve.


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First blog on Giant Bomb
By Couse 1 Comments
Giant Bomb has finally arrived. The content on this site is amazing. I love the layout and how simple it is to access any game you want. I love how there are no extreme moderators that ban you after 2 seconds of posting in the forums. Great start for Giant Bomb, and I can't wait to except nothing but the best for Giant Bomb in the future.


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On the Clippers' overall effort:
"Overall I think we did a great job as far as coming in, them being ready to play, and giving ourselves a chance to win a game."
On the Clippers' playoff experience:
"It is definitely a learning experience, only three or four people have been to the playoffs on this team, and the rest of us have just been home in April. We are still getting used to it. There are no excuses. We are still going to come out and play no matter what our experience is."
On going back to L.A. 1-1:
"We feel confident. We are happy we got one, but we are not satisfied with that. We feel like we should be going home 2-0. We just have to go home, watch some film, and regroup. A couple of our guys are banged up, they have to heal, and get ready for Saturday."
On the game:
"We came back out and had to play through a lot of adversity. We still got the win, despite what happened in last game. We came out focused and mentally tough. It's huge, because they could have easily gone back 2-and-0."
"We kept attacking and getting into the paint area. That's what we did differently tonight and got back to the free-throw line. We made good decisions with the basketball, and we didn't turn it over down the stretch. O.J. (Mayo) did a great job of handling the ball when he had times handling it. Marc (Gasol) and Z-Bo (Zach Randolph) did a great job facilitating and being aggressive when they had the chance."
"It's a grind-out game. This is more our style. Grind it out and play defense. Turn them over and get on transition. We just played hard tonight and luckily got the win."
On the next two games in Los Angeles:
"They're the most important of the series. You have to try to steal one down there in L.A., so we can get that home court back. We feel like this is going to be a six or seven-game series. Both teams are fighting hard, and we have the opportunity to go down there and win one."


text:
- Platform: Windows
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- Item Quantity: 1
Product Details
Would you like to update product info or give feedback on images?
Animal Adventures's four exotic animal habitats offer hours of adventurous fun: the African savanna, a temperate forest, the Amazon rain forest, and a tide pool. Each habitat comes with its own set of animal games and activities. Kids interact with and learn about a variety of animals, including elephants, monkeys, snakes, giraffes, rhinos, hippos, and cheetahs. A total of 16 action-packed animal activities place kids in the animals' real-world, wild habitats, or kids can create their own animal habitats.


text:
The extra character that is added to the end of a barcode is called the
check digit or check character. For barcode symbologies that do not require
a check digit such as Code 39 and Codabar, the check character may be disabled
by setting the Add Check Digit property to "No". If the check digit
is to be encoded in the barcode, but not displayed, set the Add Check
Digit to Text to "No".


text:
Master of the Katana
Edit Page Last Edit: 3 years 2 months ago
Master of the Katana
Raised the katana to level 10.
Your character isn't the only thing that can level up in Ninja Gaiden 3's Multiplayer. Earn points to level up your Katana to a max level of 10. See the Karma page for more information on how to earn experience points to level up.
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Racket face/Grip
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fuzz nation
Join Date: Oct 2006
Posts: 8,559
One thought: Be careful when thinking of your attempted winners as anything much different from your regular strokes. To hit with good pace and a good margin for error, you want to churn out enough topspin whenever you need it so that you (and the rest of us, too) can keep the ball down on the court. If you're thinking of going all in and doing something different whenever you try for a "winner", you might be trying to overcook it or come up with a miracle too often. Instead of winners, too many of those "different shots" can become errors.
Yes, definitely experiment with the idea of closing down your racquet face and taking a reasonable full swing through the ball. If that becomes your "rally mode" of hitting, you will have a better command of your topspin (and pace) more often. Eventually your "winners" will often be nothing more than those regular rally shots that you hit through open court once you get an opponent out of position.
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Figuring out which type of shoe is appropriate is just the first step in finding the right shoe, however. In a perfect world, a size 9 shoe made by Nike would fit the same as a size 9 Reebok, Saucony or New Balance. However, sizing varies from brand to brand, and even within a brand.
When trying on shoes, it's important to find a size that will leave a thumbs-width space between your toe and the front of the shoe. When you run, your feet swell but shoe uppers, the part that covers your foot, are made of synthetic materials that hold their form and don't stretch much.
There should not, however, be so much room between your toes and the end of the shoe that your heel slides up and down. "You want to make sure you have a snug heel," Hansons says. "Those are the two things you have to balance-room in fore-foot versus up-and-down in the heel."
While some training shoes carry price tags of more than $130, a high school runner should expect to spend between $70-$90. How much training you can do in a pair of trainers depends on the shoe, but 500 miles is a good high-end estimate.
Don't assume the outsole will wear down first. "You lose the cushioning in your sole usually quicker than you'll wear the out-sole through," says Hanson.
Hanson may be an expert on running shoes, but that doesn't mean he's figured out the age-old challenge of keeping them clean.
"The biggest mistake you can make with running shoes is throwing them in the washing machine," Hanson says. "That breaks down the midsole of the shoe and the 500-mile limit will be drastically cut. Your shoes are probably going to look dirty after a while, especially if you're running cross country, so wear them as a badge of honor."


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at bromo: Nightlife in the mountains
Go out and see the stars - you can actually see the milky way!!
My daughter remarked - we can see more stars because we are closer to them!!
After that - sleep early and have a good night's rest....
In front of Cemara Indah Cafe: twinkle-twinkle little stars ...
It's truely freezing condition when I decided to have a seat in outdoor lounge of Cemara Indah Cafe in the night. But look at the sky. Thousand stars are glittering and seems so near upon my head, made me sing 'twinkle-twinkle little stars'. And I find a palemoon there too. Nice. And the scenery still beautiful 'till dawn.
Dress Code: Anything that keep you warm. From socks, jacket to double-triple tee-shirts and sweat-shirt.
- Hiking and Walking
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Instant Answers: Tengger Caldera
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In this issue: U.S. Supreme Court Holds Verbal Complaints Are Protected By FISA Anti-Retaliation Provisions; Two California Jury Verdicts Underscore Proliferation of Retaliation Suits; Defendant's "Overwhelming Evidence" of Poor Performance Defeats ADA Claim; Court Refuses to Recognize Hostile Work Environment and Harassment Claims under USERRA; Ninth Circuit Upholds One-Strike Rule for Drug Testing Against ADA and FEHA Challenge; Employer's Swift and Serious Response to Initial Complaint of Discrimination Pays Off; California Appellate Court Ruling on Seventh Day Premium Pay; EEOC Issues Final Regulations Implementing ADA Amendments Act
Excerpt from 'U.S. Supreme Court Holds...'
The Supreme Court ruled last month that workers who complain about wage violations to their employer are protected from retaliation under the Fair Labor Standards Act (FLSA), regardless of whether those complaints are oral or written. Prior to this ruling in Kasten v. Saint-Gobain Performance Plastics, the question of whether verbal complaints were sufficient to support a FLSA retaliation claim was unsettled law.
The issue began when Plaintiff Kasten, who had worked at the Wisconsin manufacturing plant of Saint-Gobain Performance Plastics Corporation, verbally complained to his shift supervisor and managers about the location of the time clocks that recorded his working hours. Kasten pointed out that the clocks were placed in an area far from the dressing room where the employee usually changed in and out of their protective gear, resulting in a loss of recorded time and wages. Kasten submitted his verbal complaint through the company's formal grievance procedure.When he was later fired for allegedly unrelated reasons, he claimed that his termination had actually been an act of retaliation. The lawsuit, however, was dismissed when the district court judge ruled that FLSA anti-retaliation provisions did not cover oral complaints. On appeal, the Seventh Circuit U.S. Court of Appeals in Chicago agreed.
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Comment: In Canada snow trademarks you (Score 1) 412
by oceaniv (#25212465) Attached to: IOC Trademarks Part of Canadian National Anthem
Take that soviets. Oh and does this mean I can trademark the word "God"? If so I am happy. Otherwise I am going to continue the refrain that our society has officially jumped the shark.


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December 24, 2011
South African-based international chicken chain Nando's spurred a lot of controversy with an advertisement mocking deposed dictators last month. Well, apparently they liked the attention. Above is their latest ad, issued following the death of North Korean dictator Kim Jong-Il.
Is the ad in bad taste?
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Vote Yes for TPS on March 3 to ensure Tulsa's students have what they need so they can succeed. On March 3, 2015, citizens of Tulsa will vote on a $415 million bond for Tulsa Public Schools focused on:
The 2015 school bond is part of the district's 20-year capital improvement plan to transform and expand aging facilities and enhance school safety and security. The bond will not raise the tax rate, and projects will be overseen by the Citizens' Bond Development Committee.
If there has ever been a pivotal moment in Oklahoma's educational outlook, it is today. It is imperative that we, as a community, do not allow Tulsa's children to be provided anything less than the best possible learning environment and tools for success. Join us in voting YES for TPS on March 3.
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2015 - Copyright © All Rights Reserved / Yes for Tulsa Public Schools - Paid for by Citizens for Better Education


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Pacific pivots on China
Dawn Blitz military exercise fueled regional tensions, aspirations
Amphibious assault ships and faster aircraft like the MV-22 Osprey tilt-rotor might have saved thousands of Japanese from freezing to death after the 2011 earthquake and tsunami: "It was just heartbreaking, a tough lesson to learn because there are going to be more," he said.
The U.S. and Japanese militaries are beginning to truly integrate operations after six decades of working in parallel, he added. "That is not efficient or effective or sustainable," Newsham said. "Particularly at a time when our defense budget is pressed, to have a good ally you can operate with effectively increases your capability exponentially."
Japanese troops, aircraft and ships will likely continue their San Diego visits.
Rear Adm. Hideki Yuasa, commander of Japanese Escort Flotilla 2, said it is difficult for different branches of the self-defense forces to operate together in Japan.
"Training areas like you have in Southern California, where you can actually conduct ship-to-shore movement and, once the ground forces get to shore, they can conduct live fire training, those training areas are very limited in Japan," Yuasa said, speaking through a translator.
More than 9,000 Marines are slated to relocate from Okinawa to other bases in Guam, Hawaii and Australia. But U.S. commitment to Japan and the region is strong, said Lt. Gen. John Toolan Jr., commanding general of the West Coast Marine force. Two-thirds of the Marine Corps is stationed in the Asia Pacific. Last year, the Marine Corps revived its unit deployment program rotating forces through Okinawa to other areas in Asia.
"The Pacific is the most important area of the world for the United States in regard to economic development," Toolan said.
"If there are crises in the Pacific, we need to be able to work with our partners, work with our coalition, friends and allies in order to make sure that is a secure environment, that the economic livelihood of the United States and other countries is taken care of."
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Overview: Highlights the benefits and enhancements of the platform. (v.001, May 2011)
Platform overview covers new Intel® Atom™ processor with Intel® NM10 Express Chipset features.
Follow Jill and discover applications for the healthcare and retail industries. (v.1, July 2013)
This chalk talk video describes the features and performance benefits of Intel DDIO for Intel® Ethernet products.
The Intel® Xeon® processor E5 family merges the I/O hub onto the processor for improved efficiency.


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UPS keeps employees engaged by constantly providing learning opportunities, including tuition reimbursement, says Amy Whitley, vice president of human resources. "[W]hen we think about, 'Why do people come to UPS? Why do people stay with UPS?' we think [it's] based in learning and getting educated," she says.
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Author(s): Medema, Steven G.
ISBN 10: 0691150001. See all ISBN's
Publisher: Princeton University Press
This is an eTextbook Learn More
Adam Smith turned economic theory on its head in 1776 when he declared that the pursuit of self-interest mediated by the market itself--not by government--led, via an invisible hand, to the greatest possible welfare for society as a whole. The Hesitant Hand examines how subsequent economic thinkers have challenged or reaffirmed Smith's doctrine, some contending that society needs government to intervene on its behalf when the marketplace falters, others arguing that government interference ultimately benefits neither the market nor society.
Steven Medema explores what has been perhaps the central controversy in modern economics from Smith to today. He traces the theory of market failure from the 1840s through the 1950s and subsequent attacks on this view by the Chicago and Virginia schools. Medema follows the debate from John Stuart Mill through the Cambridge welfare tradition of Henry Sidgwick, Alfred Marshall, and A. C. Pigou, and looks at Ronald Coase's challenge to the Cambridge approach and the rise of critiques affirming Smith's doctrine anew. He shows how, following the marginal revolution, neoclassical economists, like the preclassical theorists before Smith, believed government can mitigate the adverse consequences of self-interested behavior, yet how the backlash against this view, led by the Chicago and Virginia schools, demonstrated that self-interest can also impact government, leaving society with a choice among imperfect alternatives.
The Hesitant Hand demonstrates how government's economic role continues to be bound up in questions about the effects of self-interest on the greater good.
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ISBN 10: 0691150001, ISBN 13: 9780691150000, eISBN 10: 140083077X, eISBN 13: 9781400830770
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October 16, 2003 11:15 AM PDT
VeriSign sells off domain registrar
- Related Stories
What's really behind Site Finder backlashOctober 14, 2003
Room for competition trumps VeriSign profitOctober 14, 2003
Study: Thriving Internet blighted by bugsOctober 13, 2003
VeriSign fends off critics at ICANN confabOctober 7, 2003
VeriSign says .com redirect isn't deadOctober 6, 2003
The Network Solutions business is set to go to Pivotal Private Equity, a Phoenix-based venture capital firm, in exchange for $60 million in cash and a $40 million senior subordinated note. VeriSign will also retain a 15 percent equity stake in Network Solutions.
VeriSign said it would not part with the .com and .net database it operates, which it acquired through its $21 billion buyout of an independent company called Network Solutions three years ago. That company consisted of two businesses--a registrar, which sells Internet addresses, and a registry, which directs people to Web sites.
It's giving up the registrar business, which has become essentially a commodity service in a field in which competition has been heating up. VeriSign rebranded the unit in January as Network Solutions after two years of operation under its own name and had been seeking a buyer for the business over the last several months.
What it's keeping is the registry, recently renamed as VeriSign Naming and Directory Services--and which operates in a field where the company still has a relative monopoly. The registry business, according to VeriSign, is the backbone of a global .com and .net domain name infrastructure that handles over 10 billion interactions per day.
The deal was made in order to tighten VeriSign's focus on delivering infrastructure services across Internet, telecommunications and Web security markets, a spokesman said.
VeriSign in recent weeks has been in the middle of a growing controversy over its Site Finder service, which redirects all misspelled or unassigned .com domain names to a search page it manages. On Wednesday, the company told a group of technical experts in Washington, D.C., that it plans to revive the service after having found "no identified security or stability problems" in the system.
When it was active, Site Finder added a "wild card" for .com and .net domains that snared queries to nonexistent Internet sites and forwarded them to VeriSign's own servers.
The Network Solutions transaction is expected to close in the fourth quarter.


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The Treuman Katz Center for Pediatric Bioethics at Seattle Children's Hospital will host its fourth annual international bioethics conference on July 25-26, 2008 in Seattle. Conference participants will discuss the ethical implications of genetic testing including newborn screening for risk of future disease, how these tests impact families, testing prior to adoption, how results are used by families and the medical community, technological advances in testing and why the burden of genetic information often becomes a mixed blessing. "Predicting Our Future: Genetic Testing in Children and Their Families" will be held at the Bell Harbor International Conference Center on Seattle's downtown waterfront.
"The technology, marketing and use of genetic testing is growing all the time," said Dr. Benjamin Wilfond, the center's director. "However, there is lack of clarity about what should be done with this increased information and how it affects families. States vary widely in their newborn screening practices. As testing capabilities continue to expand, particularly for adult onset diseases, we must consider whether parents should be able to make these decisions for their children. There continues to be more and more genetic knowledge available, and therefore we have increased obligations to use it appropriately and understand what it means to individuals, families and society as a whole."
With a focus on the ethical, legal and medical issues affecting children and their families, this conference will address many questions related to genetic testing such as:
|Contact: Teri Thomas
Children's Hospital and Regional Medical Center of Seattle


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Latest Dairy farming in New Zealand Stories
By EVANS, Ryan FONTERRA has been told to improve the environmental performance of its Kapuni lactose factory by Taranaki's environmental watchdog.
By JANES, Andrew FONTERRA will face a powerful new competitor across the Tasman with National Foods set to buy Australian co-op Dairy Farmers for $1.1 billion.
By BISHOP, Diane DAIRY giant Fonterra is anticipating record milk production this season on the back of last season's soul-destroying drought. And Southland's 90 new dairy conversions are being hailed as a major contributor to the industry's growth.
By JANES, Andrew New Zealand's Fonterra will face a powerful new competitor across the Tasman with National Foods set to buy Australian co-op Dairy Farmers for $1.1 billion.
By McKNIGHT Sam RECENT prosecutions of Southland dairy farmers drew an angry response from several Environment Southland councillors yesterday, who called for consent reviews for non-compliant farms.
By JANES, Andrew Rocketing prices are stalling dairy consumption across Asia. But Fonterra continues to gain market share, its new head in the area, Mark Wilson, tells ANDREW JANES . 'Ultimately demography drives economics" is a phrase Mark Wilson likes.
By JANES, Andrew SHOPPERS switching to cheaper house-brand dairy products have led to Goodman Fielder writing down the value of its New Zealand dairy operations by about a quarter. Goodman Fielder is No 2 in the New Zealand dairy market after Fonterra.
By McKNIGHT Sam ENVIRONMENT SOUTHLAND has put several dairy farmers on notice because of their repeat dirty dairying discharges. Council compliance manager Mark Hunter said a disturbing trend had emerged among some farmers who were beginning to build up a non- compliance history.
By Vasantha Ganesan FONTERRA, the dairy company whose brands include Anlene, Fernleaf and Anmum, expects Malaysia to remain its third largest market in Asia and the Middle East as it continues to innovate and market more products here.
By BASHAM, Laura They may drive our economy, but do we love our farmers and their fellow food producers enough? Laura Basham reports.
- A hairdresser.


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- Shopping Bag ( 0 items )
Doody's Review ServiceReviewer: Paolo Fanti, M.D.(University of Texas Health Sciences Center at San Antonio)
Description: This new edition of a nephrology textbook updates and expands upon the 1995 edition.
Purpose: The editors clearly meet their ambitious objectives to cover the full breadth and depth of the field of nephrology, while providing a text that is practical, readable, and useful.
Audience: This is an extremely valuable educational tool as cover-to-cover reading material for trainees in internal medicine and nephrology, and as reference for clinicians, academicians, and educators. Edited by two leaders in the international arena of nephrology, the book enlists an impressive roster of authors, all experts in the topics they cover.
Features: The book is comprehensive, covering normal anatomy, physiology and metabolism of the kidney, clinical physiology and pathology, specific disease entities, hypertension, renal failure, and all forms of replacement therapy, including transplantation. In a book without weaknesses, areas that stand out are those dedicated to glomerular disease and to uremia. The literary style is beautiful and the organization and clear presentation are impressive, reflecting the gift that both editors have as teachers and academicians. Departing from the organizational style of most other textbooks of nephrology, the editors elect to avoid citation of specific references throughout the text. Instead, each chapter closes with a list of several key references, each supplemented by a brief description of its importance. This approach seems to allow more flexibility to the authors, while making the reading very enjoyable.
Assessment: The editors have worked hard at updating this fourth edition in order to reflect the most current knowledge in the field. They present us with an extremely valuable textbook and an important educational tool. This book is highly recommended to all physicians who have an interest in any nephrology-related area of medical knowledge.


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'Most affordable'
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After UVM. University of Vermont students are highly successful after graduation, whether in the job market or graduate school. See how UVM contributed to their success.
Paths To Success:
Alexandria Hall
English major, poet, Beinecke Scholarship winner
Joseph Friedman '14
Anthropology major, Fulbright scholarship winner, focus on domestic and global research related health metrics
Hilary Hickingbotham '14
Mechanical engineering major, employed at UTC Aerospace before graduation
Melissa Perry '88
Chair, Department of Environmental and Occupational Health, GW University
Lowell Bailey '05
Olympic athlete, Sochi competitor in winter biathlon
John Hall '85
Rachael Ray COO
Tim Stewart '09
Co-owner, Pop Nation popsicle company
William A. Meezan '67
National expert on child welfare, supporter of UVM's LGBTQA Center
Courtney Hennessey '99 and John Stoddard '99
Owners, Higher Ground rooftop farm
Zachary Wright '05
Teacher, Philadelphia Outstanding Teacher of the Year
Nilima Abrams '06
Documentary filmmaker, Fulbright recipient
John Dineen '86
CEO of GE Healthcare
Luke Neill '11
Medical student, co-developer of patient software
Chris Walters '96
Chief Operating Officer, The Weather Channel
Brent Summers, '12
Former Vermont Cynic editor-in-chief, New York Times contributor
Sasha Fisher '10
Co-founder, MicroGrants non-profit
Akol Aguek '05, G'11
Master's student in international affairs and social policy, Harvard
David Hyman '89
Founder and CEO, MOG music streaming service
Rachel Comey '94
Fashion designer
Megan Piro '08 and Emily Rodney '09
Employees of Martha Stewart Living Omnimedia
Robert Rosenthal '71
CAREERS: Where have recent grads gotten jobs?
- Alaskan Observers, Inc., Fisheries biologist
- Applied Biosystems, Production chemist
- AT&T, Associate manager of finance
- Bloomberg LP, Analyst
- Burton Snowboards, Marketing manager
- Dana Farber Cancer Institute, Clinical researcher
- Federal Aviation Administration, Technical writer
- Fidelity Investments, Software developer
- Green Mountain Coffee Roasters, Product development scientist
- Juvenile Justice Center, Social worker
- L.A. County Public Works, Civil engineer
- Maryland Citizens Health Initiative, Political consultant
- Mellon Financial, Trust specialist
- National Institutes Of Health, Research fellow
- Senator Patrick Leahy, Outreach staff
- Teach For America, Managing director, IP
- Vermont Department Of Energy Conservation, Environmental analyst
ADVANCED STUDY: Where do recent grads go to grad/med/business school?
- Dartmouth College, Engineering
- University of Chicago, Economics
- Cornell University, Physics
- Yale, Forestry
- Tufts University, Veterinary medicine
- Columbia University, Medicine
- Pennsylvania State University, Business
- Massachusetts Institute of Technology, Urban planning
- Johns Hopkins University, Psychology
- University of California Berkeley, Environmental design, molecular genetics
- Brown University, Anthropology
- University of Michigan, Law
- Harvard University, Chemical biology and molecular pharmacology
- Scripps Oceanographic Institute, Oceanography
- Rhode Island School of Design, Studio art
- Oxford University (U.K.), History
- Brandeis, English
- Georgetown University, Public policy