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The Iguana Compatibility Test
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Cozy Bean BagsChennai, Tamil Nadu
Call Us:
Products & Services
Company Profile
We are one of the most preferred manufacturers and suppliers of different types of Bean Bags and Accessories. These are very popular due to their superior quality and distinctive features.
Fact Sheet
|Year of Establishment
|Legal Status of Firm
Sole Proprietorship (Individual)
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Upto 10 People
Rs. 50 Lakh - 1 Crore ( or US$ 100 K - 200 K Approx.)
Contact UsCozy Bean Bags T. V. Manoj Kumar SaxenaCall Us:
No. 37 F, 1st Floor, Vijay Nagar, Main Road, Behind Adayar Ananad Bhavan, Velachery
Chennai - 600042
Tamil Nadu, India
Chennai - 600042
Tamil Nadu, India
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Shop up a storm in Cape Town
Rob PetersCape Town is a shopper's dream with a wide range of shopping expeditions to undertake - from luxury boutiques and shopping malls to private shopping tours and markets. Take a look at some of the top spots to shop up a storm in the Mother City.
All you need to know about the new child visa regulationsNew laws about travelling with children come into effect on 1 June 2015. To assist travellers to South Africa with their plans, Cape Town Tourism has created a summary of some of the typical questions that come up for parents travelling with children or who wish to send their children on a trip.
Your #lovecapetown weekend: What's on from Wednesday 27 May to Sunday 31 May, 2015
Rob PetersCape Town is a golfer's paradise with an abundance of world class golf courses to choose from across the Mother City. From parkland courses to links layouts, the needs of all golfers will be satisfied – and then some – whether they are professionals or rookie hackers. So get ready to come out swinging on the most epic golfing weekend ever!
Cape Town's Church Street and all its charmIT'S just a tiny little pocket of the Cape Town CBD but it's jam packed with interesting things to see and do. I'm talking about Church Street between Long and Burg streets.
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All you need to know about the new child visa regulations
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FNB Cape Town 12 OneRun in Cape Town
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Your #lovecapetown weekend: What's on from Wednesday 27 May to Sunday 31 May, 2015
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Five fun things to do in Cape Town with your family
For those of you who are lucky enough to still be on summer vacation, why don't you enjoy the rest of the summer holidays with your family at these fun family-friendly venues in Cape Town
Facebook Feedback Fridays: Your recommended Cape Town accommodation hotspots
As we enter the holiday season, we welcome new and returning visitors to our beautiful city. Here's what you guys recommended for guests spending their holidays in the Mother City.


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ZUO - Heywood - Living Room BenchProduct Id: 419576 Phone Code: EA4A-F7BA
Regular: $689.00 Sale: $458.00 (You Save 34%)
Because this item is so popular, it is on backorder until July 01, 2015. Orders are filled in the order they are received. If you are interested in this piece, we suggest placing your order to get the earliest available delivery.
Product Description
A classic of Mid-Century Modernism, the Heywood bench is beautiful yet utilitarian. Made of a natural wood top.
- Finish: Chrome Steel
- Color: Natural
- Made of a natural wood top.
- Contractor Use: Yes
- Assembly is required
- Overall Product Dimensions: 14" H x 60" W x 15" D
- Net Weight: 35.4 lbs


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In Celebration of Women
Sojomail - May 10, 2012
"SNAP participation at farmers' markets helps provide fresh fruit and vegetables to families and expands the customer base for local farmers - a win-win for agriculture and local communities." - Kathleen Merrigan, deputy secretary of agriculture, on the growing number of farmers markets now able to accept food stamps. (Source: Associated Press)
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This Sunday is Mother's Day. Here at Sojourners, we're taking the entire week to celebrate not only mothers, but all women who have made an impact on our lives. For their strength, heroism, charity, and wisdom, we honor them.
1. We Love Our Sisters
2. Examining the Realities of Women in the U.S.
3. Invest in Women
4. Celebrate Mother Earth
5. It's Mother's Day Week
+ See what's new on the blog of Jim Wallis and friends
Bare Feet and Dolphins: Rob Bell's Return
'Four Dead in Ohio': Forty-Two Years Later
Austerity is Losing, But What's the Alternative?
Motherly-ness: Shaping a Woman's Soul
Mothers Day: Supporting All Women
Mother's Week: Standing Up For Fairness
A Gift for Mother's Day
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Virus Decimating Spanish Amphibians
October 20, 2014|
Several toad, newt, and salamander populations are being hit hard by an emerging pathogen in a pristine national park in Spain.
Daily News Roundup
October 20, 2014|
Several toad, newt, and salamander populations are being hit hard by an emerging pathogen in a pristine national park in Spain.
September 30, 2014|
Mix of public, private, philanthropic, and academic investments will fund additional BRAIN Initiative-related projects.
September 18, 2014|
Government auditors absolve the National Institutes of Health of wrongdoing in the case of its involvement in an ethics investigation of a study involving premature babies.
September 9, 2014|
A search for long-forgotten pathogens at the US National Institutes of Health prompts the discovery of toxins and disease-causing agents.
September 2, 2014|
The ongoing Ebola outbreak has prompted the National Institutes of Health to accelerate human trials of multiple Ebola vaccines, starting this week.
August 28, 2014|
Updated guidelines expand upon existing policy to include more kinds of data.
August 22, 2014|
Samples from an Antarctic lake 800 meters below the ice reveal an abundance of microbial life.
July 24, 2014|
African elephants have more genes for olfactory receptors than dogs or humans, a study shows.
July 15, 2014|
After a string of incidents leading to lab closures and a moratorium on the transfer of select agents, US labs are reassessing safety threats within their own walls.
July 10, 2014|
The effects of neonicotinoid use on insect populations appear to be rippling through the food chain, scientists show.


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You selected: Engineering
Wiley Survey Offers New Insights to Aid Academic Associations
Hoboken, NEW JERSEY- March 18, 2015 — Results from a survey of researchers and research-based professionals by John Wiley & Sons, Inc.— the world's largest society publisher with more than 900 society partnerships — reveal the most valued benefits offered to members by scholarly societies.
The Future of "Bioprocessing" for Medical Therapies
What's in store for the future of industrial bioprocessing for medical therapies, which involves the use of living organisms or cells to create drugs or other agents? Will the batch or continuous bioprocessing platform dominate biomanufacturing of human therapeutics down the road? Three pioneers in the field address these questions in an upcoming issue of Biotechnology and Bioengineering.
Wiley Launches Premium Open Access Journal Advanced Science
John Wiley and Sons, Inc., today announced the launch of Advanced Science, a new premium, interdisciplinary open access journal.
Wiley Announces Project Management 2.0
Get connected and improve outcomes with a more modern approach to project management
Designing Brand Identity
A revised new edition of the bestselling toolkit for creating, building, and maintaining a strong brand
Wiley Announces Continued Growth in Titles with Impact Factor
John Wiley & Sons, Inc., today announced a continued increase in the proportion of its journal titles indexed in the 2014 release of Thomson Reuters Journal Citation Reports® (JCR). A total of 1,202 Wiley titles (approximately 70%) were indexed, up from 1,193 in the 2012 JCR, and including 13 titles which have been indexed for the first time.
Replacing Coal and Oil with Natural Gas Will Not Help Fight Global Warming
Both shale gas and conventional natural gas have a larger greenhouse gas footprint than do coal or oil, especially for the primary uses of residential and commercial heating.
Designing for the Third Age
Designing For The Third Age: Architecture Redefined for a Generation of 'Active Agers' reflects on the challenges facing most industrialised nations as people aged sixty-five and older continue to constitute an increasing proportion of the population. This book offers innovative responses to these problems on a practical and speculative level.
APEC to recognize 'intelligent transportation' innovator
APEC has opened the nomination period for the APEC Science Prize for Innovation, Research, and Education, also known as the ASPIRE Prize, sponsored by John Wiley & Sons, Inc., and Elsevier, which in 2014 will honor a young scientist whose work has made an outstanding contribution to 'intelligent transportation.
Walk-in access to high quality academic research available in UK public libraries
Students, independent researchers and small businesses can now access many of the world's best academic papers across science, technology, medicine and other disciplines through their local libraries. This is the result of a unique collaboration between librarians and publishers, who have made their journal content available for free to UK libraries under a new initiative, Access to Research.
Generation Gap in Authors' Open Access Views and Experience, Reveals Wiley Survey
John Wiley & Sons, Inc., today announced the results of its 2013 author survey on open access, with over eight thousand respondents from across Wiley's journal portfolio. The survey is a follow up to Wiley's 2012 open access author survey and is the second such survey conducted by Wiley. This year new sections were added including research funding and article licenses.
Exploring Arduino: Tools and Techniques for Engineering Wizardry
Expert author Jeremy Blum teaches readers everything they need to know about Arduino to help them build their own projects and succeed using this versatile microcontroller platform
How Shale Fracking Led to an Ohio Town's First One Hundred Earthquakes
From: Geophysical Research-Solid Earth
Miniature Arm Lifts Weights: Artificial muscle contracts and expands with changes in humidity
A small plastic strip can do "weight training" to effortlessly lifts many times its own weight, driven by cyclic changes in the humidity of the surrounding air. This strong "artificial arm" is based on the interaction between microgels and a layer of polycations that shrinks as it dries, according to a report presented by Canadian researchers in the journal Angewandte Chemie.
Stirred, Not Shaken: Nanoscale magnetic stir bars
Anyone who has ever worked in a laboratory has seen them: magnetic stirrers that rotate magnetic stir bars in liquids to mix them. The stir bars come in many different forms—now including nanometer-sized. In the journal Angewandte Chemie, researchers from Singapore have now introduced chains made of 40 nm iron oxide particles that act as the world's smallest magnetic stir bars, effectively stirring picoliter-sized drops of emulsion with a commercial magnetic stirrer.
Drinking Water from the Sea: Electrochemically mediated seawater desalination in microfluidic systems
A new method for the desalination of sea water has been reported by a team of American and German researchers in the journal Angewandte Chemie. In contrast to conventional methods, this technique consumes little energy and is very simple. This electrochemically mediated seawater desalination is based on a system of microchannels and a bipolar electrode.
Three New Reference Works from Wiley
Ullmann's Renewable Resources
Ullmann's Reaction Engineering, 2 Volume Set
Industrial Biotechnology: Upstream Fermentation, Downstream Recovery and Purification, 3V set
Wearable Electronics: Highly conductive textiles and paper with aluminum
Jackets with built-in mobile phones, sports clothes that warn you when your heart rate gets too high, wallpaper with glowing patterns—these are not concepts from a science fiction movie, some of them are actually already available, and they may soon become commonplace. These applications require electrically conductive fibrous materials. Korean researchers have now developed a new process for rendering paper and textile fibers conductive with aluminum. Their report appears in the journal Angewandte Chemie.
Just How Useful is Fracking? Study Explores Return of Investment
From: Journal of Industrial Ecology
Making Colors from Black and White: Colorfast pigments made from amorphous arrays of silicon dioxide and carbon black
It is very annoying when colors fade over time, sometimes simply from exposure to light. In the journal Angewandte Chemie, Japanese scientists have now introduced a new type of colorfast, environmentally friendly pigment. These consist of submicrometer-sized silicon dioxide particles and carbon black and are simply sprayed on to the desire surface. The resulting color is tough and does not fade.


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» Preconception
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Welcome to a place for ideas, insights, mom-to-mom (and dad-to-dad) wisdom, and most of all, unconditional support, from those who've been there, done that, lived to tell about it...and tell it like it is.
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The Risks Of Taking Clomid - Weighing In
Preconception |
Word of Mom Blogs
Of course, the first thing that comes to mind when you start taking a new medication is whether or not you'll have any side effects. Clomid is no different. I researched the risks of taking Clomid well before I even started taking it. I knew that taking Clomid might be a definite possibility for me in the future, and I wanted to be prepared for ...
The Prolactin Level Test and TSH, too
Preconception |
Word of Mom Blogs
Wow. At this point, what isn't getting tested? I've blogged about a progesterone level test, an fsh blood test, an estrodial test, and an lh blood test. All that, and I'll have a prolactin level test, too. The prolactin level test and a tsh lab test are both going to be tested on cycle day three with the other stuff. (Except for the...
Real Mom Advice
The Pressure to Have Baby Number Two
Preconception |
Rebecca Desfosse
Now that my son is almost three, I'm starting to feel the pressure to have baby number two. It comes from everywhere — well-meaning friends, in-laws, random strangers. It's odd, everyone just expects us to have another baby. But I'm not yet sold on the idea. Give me another six months (years?). If you're feeling torn about having baby number two...
In the News
Timing Your First Baby to Perfection
Preconception |
Carolyn Buchanan
A recent editorial in the New York Times unleashed a lot of controversy about the best time to have a baby. In the piece, medical student and new mother Anna Jesus wrote about having a baby in her 20s at the same time she was in graduate school. It wasn't her intention; she'd imagined waiting until her career was fully launched, but when an...
Symptoms Of Conception - Are There Any
Preconception |
Word of Mom Blogs
It's not uncommon for me to wonder and analyze each and every pain I feel and wonder if I am experiencing the symptoms of conception. It gets so bad that I convince myself each month that I am indeed pregnant and of course, as you all know, I never am. This leaves me questioning myself and wondering if the symptoms of conception will...
Symptoms of Conception - Flashing Red Belly Button
Preconception |
Word of Mom Blogs
*Disclaimer – Another blog post in my trying to conceive series concerning the symptoms of conception and the two week wait. Today I am four days past ovulation and have no symptoms. Nothing. Nothing new or unusual. Today I am four days past ovulation and have no symptoms of conception. I hate not knowing. We did everything...
In the News
Study Shows Women Are Taking
Health More Seriously
Preconception |
Carolyn Buchanan
Want a healthy baby and to be a healthy mom? Taking good care of your pre-baby self goes a long way toward guaranteeing both. As part of their 2020 Healthy People campaign, the Centers for Disease Control (CDC) has taken a special interest in the pre-pregnancy health of women in an effort to ensure good health of the next generation. The CDC...
Spotting After a Miscarriage – Still Confused
Preconception |
Word of Mom Blogs
Today marks the fifty-fifth day since my husband and I lost our first pregnancy to a miscarriage on September 15. This evening at approximately 10:00 pm also marks forty-eight hours since I first began experiencing some light spotting after a miscarriage. When I first discovered a small amount red blood in the toilet and on the toilet paper, my ...
Spotting Can Be A Sign Of Infertility?
Preconception |
Word of Mom Blogs
I am hopefully fast approaching the day when I can finally call to make an appointment with a doctor, thus I have been doing so research about infertility. I was reading through my book "Taking Charge of Your Fertility," by Toni Weschler, when I discovered that spotting a few days before menstruation can actually be a sign of infertility. I was ...
Severe Anxiety During Pregnancy is Really Starting to Scare Me
Preconception |
Word of Mom Blogs
Severe anxiety during pregnancy is not something I have ever had to deal with before. During all of my previous pregnancies, I never once dealt with anxiety attacks or depression. Of course, after my pregnancies was a different story. While I never dealt with anxiety, postpartum depression was something that I battled after each one of my...
Health and Wellness
Sarah Silverman Is Afraid of Passing Depression on to Her Kids
Preconception |
Tiffany Raiford
Depression is not something that should be taken lightly. It can be a terrible disease that affects the lives of both those who have it and those who live with them. According to Time, comedian Sarah Silverman she would not have biological children because she suffers from depression and doesn't want to pass it on to her child.On the one hand,...
Risk of Endometriosis Greater in Slim Women Than Obese Women
Preconception |
Joanne Van Zuidam
Leaner women have a greater risk of developing endometriosis than women who are morbidly obese, says a new study published in the journal Human Reproduction. The authors of the study stress that their research did not prove that low BMI causes endometriosis — just an association between the condition and BMI. Further research is needed to...
Real Mom Advice
Remedies for Painful Period Cramping
Preconception |
Elizabeth Dunn
When I was a teenager, I suffered from extremely painful cramping during my period. I thought it was normal and couldn't understand why my friends were not dealing with the same pain. A few years later, I realized it was not normal to spend two days in bed with severe pain each month.I made an appointment with my doctor to discuss the pain and to...
Real Mom Advice
Reliably Estimating Child Costs Is Pretty Much Impossible
Preconception |
Cosima Brand
Before I had my son, I made lists of all the possible costs and tried to estimate how much I'd spend each month. I realized that estimating child costs is really an exercise in futility.For example, I tried to estimate the number of diapers I might need in a month by Googling the number of diapers a baby goes through. Of course I found multiple...
Questions to Ask Doctor After a Miscarriage
Preconception |
Word of Mom Blogs
I have an appointment to see my OBGYN tomorrow at 3pm. It is my first appointment after a miscarriage. I do not really know what to expect, but I wanted to make sure I got to see a doctor in person to have questions about life after miscarriage answered rather than just briefly talking to a nurse on the telephone. I do not know if she will give ...
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- Price: $64.00
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Proposotion Business Website Template 27555
CSS Full Site Flash 8 Website Template that was composed by our webmaster artist Astra. It is also available as Mobile Template 28588.
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Description, Sources, Software & Requirements
This website template is dark gray in color with blue, yellow, and green. There is a menu bar at the top in yellow. The image is of the globe with two arrows going around it. This website template could be good for a global business and international communication. Proposotion Business Website Template 27555 has a width of 1400 pixels and is available in the following sources: .SWF, .HTML, .PSD, and .FLA. Software required includes Winzip 9+ (Windows) or Stuffit Expander 10+ (Mac) for uncompressing .zip files, Adobe Dreamweaver 8+ (or Microsoft Expression Web), Adobe Photoshop CS+, and Adobe Flash 8+. It has had a total of total of 4 downloads since it first appeared. Please click on the template pages links above to see screenshots from other pages of this template.


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"La Soiree"
Monday, December 30, 2013
Brett Haylock, Ursula Martinez, and Le Gateau Chocolat, on their show, "La Soiree," a hybrid of sideshow, vaudeville, and burlesque. "La Soiree" is playing at the Union Square Theatre.
Guests:Le Gateau Chocolat, Brett Haylock and Ursula Martinez
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Welcome to the New Team Members
- Posted On: October 13, 2014
- Author: Collin McConville
- Categories: Support Local, Staff, Events
Hello everyone!! I hope you are all having a wonderful fall so far -- the weather here has been rather nice.... considering we have had nothing but rain all year. We have been expanding our product lines over the past couple of months and look forward to releasing a number of new products in the next couple of weeks (more on that in a later post I promise). I wanted to take this time to introduce our new team members. We are steadily growing and have started to bring on new members to fill roles that we no longer had time for.
Tree Vodka


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posters, haunted house posters, abstract posters, magic posters, line posters, thick posters, texture posters, sweater posters, space posters, architecture posters, happy posters
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Posters ship within 3 - 4 business days in durable cardboard tubes.
As a child, I remembered escaping to The Last Unicorn and Beetle Juice as my first two obsessively watched movies. Both gave an odd context between sweet unicorns and dark humored ghosts thus bringing a confusing combination of delusional death and eternal magic. But, I became interested in a crazy world of talking objects as �Pee-Wee�s Playhouse.� Talking food was especially attractive; I wanted to open up another world inside my refrigerator to voyeur a claymation world. This Television show oozed a twisted, dark humor but fed my obsessive lust for eclectic chaos. To continue my childhood development, I visited Walt Disney World yearly with my family; it provided Mary Poppins� �practically� perfect existence to reap escapism...
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Gaucho Gazette > September 2011 > Student Affairs
International Student Completes Internship
Jakub Szymanski, a former GCC international student from Poland, completed an internship this summer in our International Education Office as part of his bachelor's degree program at the University of St. Francis in Joliet, Ill.
Intern Kuba Szymanski
Szymanski,who goes by the nickname "Kuba," attended GCC three years ago and played on the Gaucho men's tennis team. He received a scholarship from the University of St. Francis to play tennis while working on a bachelor's in sports management. His degree requirements include doing an internship for credit, so he submitted a proposal to his academic advisor to intern in the International Education office at GCC. The advisor approved this proposal because USF does not have an office dedicated to serving international students. The idea was that Szymanski could learn enough in the summer internship to help them set up a program at USF.
Szymanski, spent the summer learning about GCC's IE policies and procedures, especially those pertaining to international students, such as admission policies, visas, passports and immigration. He interviewed GCC employees to learn more about their jobs and responsibilities. And he took careful notes, eventually producing an entire manual documenting everything he learned at GCC.
He was able to help with the special one-day orientation program for new international students on Aug. 17, when GCC welcomed more than 50 new students from approximately 20 countries to the campus. Aug. 18 was his final day at GCC and it was also the day he heard from USF that he graduated with his bachelor's. He is now at USF with a scholarship working on a master's in business administration. The scholarship includes an assistantship aimed at developing a special program for international students at USF, where Kuba hopes to replicate the Glendale model. -- submitted by Ken Bus, director International Education Program
September 2011 Contents:
Presidential Perspectives
Academic Affairs
Administrative Services
Student Affairs
Around Campus
Staff and Contacts
All Gaucho Gazette Issues


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The early-morning operation has stunned football with many leading federation members of embroiled - follow Loretta Lynch's press conference here
YASMIN Gasimova might remove her natural beard - but her belly, leg and underarm hair are here to stay as she unashamedly tells people: "Being hairy isn't scary".
BLAIR has held the post for the Quartet on the Middle East - made up of the UN, US, EU and Russia - for almost eight years.
The early-morning operation has stunned football with many leading federation members of embroiled - follow Loretta Lynch's press conference here
Her Majesty has revealed the agenda of the first majority Tory government in almost two decades. Here are all the updates as they happened
The east coast resort Hotel Club Cala Pada where the tragedy took place is particularly popular with British tourists
THREE people were gored during a bull run to celebrate the traditional Festival of the Crosses in the Peruvian town of Huancavelica.
SWISS officers made the arrested at the request of the US government, which intends to charge the football officials with corruption.
JIMMY Pyke, now 96, was one of the last men off the beach as soldiers headed back to Britain on a rag-tag flotilla of boats and ships.
Ted Dockray, eight, was thrilled when he caught the shirt, thrown into the crowd by Preston North End's Jermaine Beckford in Sunday's League One play-off final
MANDY Yousaf, whose daughter Charlotte tragically died following a paracetamol overdose, is urging teenagers who are tempted to take part in a bizarre 'Paracetamol Challenge' social media craze believed to have originated in Scotland not to end up like her daughter did.
THIS happy hippo baby enjoyed a game of peek-a-boo as she went for her first public swim at the weekend.
Marine Corporal Caleb Earwood is photographed eyes shut and holding the hand of his sobbing bride-to-be so they didn't see each other before the ceremony
THE footage shows Whitney Mongiat kicking off after her husband James tells her she can't spend the day on the lake because he has errands to run.
"I am not in competition with anyone. Don't compare me to anyone cos I'm my own person," she told the mag
James Callan and his partner Lauren claim they received no warning before double yellow lines were painted directly in front of their drive


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People think it's easy to make a spoof movie. Like, all you have to do is throw a bunch of random shit in a bowl, mix it up with some topical references and pour it out onto 35mm film strip and you'll make people laugh. Anyone who's seen Epic Movie or Meet the Spartans knows that this isn't true. And anyone who's seen the newly released Scary Movie 5 trailer (which you can watch below) definitely knows that. The best kind of spoof movie is the one that finds a way to remain amusing beyond an expiration date. Yes, we all love Naked Gun 33 1/3: The Final Insult, but unless you grew up in the early 90s, there are far too many references and in-jokes you won't get–one of the many reasons why Date Movie, Epic Movie, Disaster Movie, Meet the Spartans, and so on and so forth, will never be rewatched, because their shelf life is barely past the opening weekend with all the topical references made. (Let's not even mention that they're also atrociously unfunny regardless of their topicality).
No, the best spoofs are the ones that are smart enough to focus on one popular genre. Loaded Weapon 1 were the Shane Black-esque 80s action movies. Austin Powers was the spy genre. Naked Gun was gumshoe police procedurals. And that's why people still annoying quote 'Don't call me Shirley' thirty-two years after Airplane was released.
So if you picked the right week to stop sniffing glue, check out the Ten Best Spoof Movies Ever.


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Country Cooking
Alice doesn't live here anymore–and how that made Calvin Trillin feel
More News from Micky Fenix
More News from Philippine Daily Inquirer
My article on the Time-Life book collection "Foods of the World" and how I'm trying to complete my set had readers e-mailing me with suggestions on just what to do.
One taught me how to bid for the books on eBay, the Net's digital shop, while others graciously offered me their own copies (thank you). I wrote then that I've been doing my own search in bargain book stalls.
The book hunt at bargain places is what I've introduced to chefs during our culinary competition judging in many parts of the country. There, second-hand reads can be had for a few pesos. It's almost unbelievable that hardbound copies of recipes and food books can cost less than a hundred.
There were times when our hunt turned up copies of books currently sold in bookstores, but at a tenth of the price. But my greatest moments are when I discover a book that I never knew was printed, so that it completes a particular collection.
Prodigious talent
One book seemed to call out to me with its title "About Alice." Then I saw the author's name, Calvin Trillin, one of my favorite writers, who tackles eating and so many other subjects with a humorous point of view. A prolific writer, Trillin has a column in The Nation magazine called "Verse Columnist," although the magazine would rather call him "deadline poet" because of his prodigious talent in reportage and commentary.
"About Alice" is Trillin's memoir of his wife who died of heart failure due to lung cancer. The book became a New York Times bestseller, and I'm thrilled to have this treasure in my library, which already includes several Trillin books.
One of them, "American Stories," has a chapter on the competitive tactics Ben & Jerry's Homemade Ice Cream employed to rattle its more conservative rival, Häagen-Dazs. Trillin's three earlier food books were compiled in the volume "The Tummy Trilogy." One of them is "Alice, Let's Eat."
Trillin's penchant for teasing is evident in the first chapter, where he reveals that his wife "has a weird predilection for limiting our family to three meals a day."
Main course
It was in another book, again discovered at a second-hand store, where Calvin and Alice Trillin were mentioned as guests at a lunch.
"The World in My Kitchen" by Colette Rossant relates how she always invited the Trillins to sample the new ingredients she discovered in New York's Chinatown. Once, after a soup of cauliflower and blue cheese, Alice, who was expecting their first child, said they had to go because she felt she was having labor pains.
Calvin was hesitant and said: "But I don't know what Colette is serving for the main course!"
Rossant's main course was roasted quails with water spinach and sautéed water chestnuts, which she wrapped for the couple to take out. And then she mentioned how Calvin wrote about her in "Alice, Let's Eat," calling her one of his favorite New York cooks.
That made me open the Trillin book, and there Rossant was described as "the Scourge of Sullivan Street" because she insisted on having good fresh produce, and never hesitated to berate vendors who gave her anything less.
"She is so far above frozen food," he wrote, "that I have always suspected she may not keep ice cubes."
Before discovering this recent Rossant book, I already had two of her books in my collection, both bought at a regular book store. "Apricots on the Nile" is about growing up in Egypt with her father's family. Rossant's mother was French and it was in Paris where she spent her college years, which are recounted in "Return to Paris."
Her early married years is what Rossant wrote about in "The World in my Kitchen"—how she settled with her American husband Jimmy in New York, and then built a family and career as a French-language teacher, cooking teacher and food writer. Each of those books featured recipes of the dishes she discussed or whipped up.
Book connection
I thought the book connection ended there. But Trillin also mentioned in the memoir the author Dick Francis, a favorite mystery writer of mine who, when his wife Mary died, wrote: "I don't think I shall write again other than letters now… So much of my work was her."
There were several Dick Francis novels I bought at those bargain book stalls, many at around P30—cheap thrills, really. Francis' breezy writing and suspenseful plots made time fly, especially on long plane flights and at the waiting rooms of doctors.
Trillin said he understood that reluctance to write again because Francis must have been trying to impress only his wife with his work. But Trillin actually said it in the dedication of one of his novels. It reads: "I write this for Alice. Actually, I wrote everything for Alice."
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Apache catches Google Wave in a box
November 29, 2011 | 12:18 am
By Chris Meadows
About a year ago, I mentioned Google's decision to stop active development on Google Wave, and the Apache Foundation's subsequent move to take ownership.
More recently, Google announced it will shut Wave down entirely in April 2012. Wired's Webmonkey column reports that Apache's efforts with Wave are now available in the form of "Wave in a Box", a standalone client/server application that replicates the Wave experience.
Wave in a Box consists of two parts, a standalone wave server and a web client. The Wave in a Box web client looks a bit different than Google's Wave user interface, but the same features are present. The Wave in a Box tools also have the distinct advantage of decentralization. Developers can run wave servers and host waves on their own hardware without Google being involved in any way.
This will be a great resource for those who liked Wave and want to keep using it after Google closes it down, or who dislike Google having access to their collaborative information. Of course, there are plenty of other collaborative editing tools out there as well.
A lucky Robert Aickman find: The Fourth Fontana Book of Great Ghost Stories
Are Amazon editors really that independent?
Editors should play nice with agents and authors, says Agent Orange
Storium enters last day of Kickstarter with educational version fully funded
Storium Kickstarter turns writing into a game, seeks to fund educational version
Try Rizzoma.com if you are looking:
for alternative solution to Google Wave
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text:
Latest John F. Kennedy Stories
Seven redeveloped Hudson shops, new Victoria's Secret enhance American Airlines terminal NEW YORK, Feb.
PEARLAND, Texas, Feb. 12, 2015 /PRNewswire/ -- Neighbors Health System, owner of Neighbors Emergency Center, announced a strategic partnership with HKS Architecture.
Airline Launches a Network-wide Fare Sale with Fares from $89* JFK- FLL and a Chance to Win a Lux "Thaw Out in Florida" Winter Escape at Mondrian South Beach and Free Car Rental from Sixt** SAN
NEW YORK, Dec.
New JFK facility will meet the increased demand for temperature controlled shipments RESEARCH TRIANGLE PARK, N.C., Dec.
In an address to Congress in 1961, President John F. Kennedy challenged the nation to "land a man on the moon and return him safely to Earth" before the end of the decade. With the flight of Apollo 12, 45 years ago this month, NASA achieved that goal a second time.
The Airline's Seasonal New York-Fort Lauderdale and Boston-Las Vegas Routes are on Sale Now; Guests Are Invited to Start Planning a 'Winter Thaw' with Deals and a 'Sun-Inspired Selfie' Competition
BOSTON, May 7, 2014 /PRNewswire/ -- Today, the Edward M.
Emmy- and SAG-nominated Actor Returns to Network Following His Critically Acclaimed Starring Role in Last Year's KILLING KENNEDY WASHINGTON, April 23, 2014 /PRNewswire-USNewswire/
Russell Simmons and Rosario Dawson Lead Judges in Contest SAN FRANCISCO, April 7, 2014 /PRNewswire-USNewswire/ -- Youth Speaks today announced a new youth hip hop and spoken word
- An uxorious, effeminate, or spiritless man.
- A timorous, cowardly fellow.


text:
First Known Use: 1796
adjective con·gen·i·tal \kən-ˈje-nə-təl, kän-\
: existing since birth
: naturally having a specified character
Full Definition of CONGENITAL
a : existing at or dating from birth <congenital deafness>b : constituting an essential characteristic : inherent <congenital fear of snakes>c : acquired during development in the uterus and not through heredity <congenital syphilis>
: being such by nature <a congenital liar>
— con·gen·i·tal·ly \-təl-ē\ adverb
See congenital defined for English-language learners
See congenital defined for kids
Examples of CONGENITAL
- The irregularity in my backbone is probably congenital.
- <a congenital liar who couldn't speak the truth if his life depended on it>
Origin of CONGENITAL
Latin congenitus, from com- + genitus, past participle of gignere to bring forth — more at kin
Related to CONGENITAL
- Antonyms
- nonnatural
See Synonym Discussion at innate
Other Genetics Terms
adjective con·gen·i·tal \kän-ˈjen-ə-təl\ (Medical Dictionary)
Medical Definition of CONGENITAL
: existing at or dating from birth <congenital deafness>
: acquired during development in the uterus and not through heredity <congenital syphilis>—compare acquired 2, familial, hereditary
—con·gen·i·tal·ly \-təl-ē\ adverb
Learn More About CONGENITAL
Next Word in the Dictionary: congenital amputationPrevious Word in the Dictionary: congenialnessAll Words Near: congenital
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text:
I am glad to see that they are willing to raise the pay of their midlevel fighters.
According to MMAJunkie, former "The Ultimate Fighter" season 1 veteran, Chris Leben has signed a two year multi-fight contract to fight in the UFC.
MMAjunkie.com (www.mmajunkie.com) has confirmed that the new deal will pay him $25,000 "to show" and $25,000 as a "win bonus" for each fight of the new deal. (The figures were first revealed in his MySpace interview.) Leben had been making just $10,000 to show and $10,000 to win since his official UFC debut in April 2005.
Last year Leben threatened to leave the UFC in favor of Hawaii's ICON Sport ,if his pay was not increased. Leben currently coaches and trains at the ICON Sport fitness center in Honolulu Hawaii.
Chris Leben takes on Alessio Sakara at UFC 82 on March 1 from Nationwide Arena in Columbus, Ohio.
I am glad to see that they are willing to raise the pay of their midlevel fighters.
ok that sounds a lot better. $25K min per fight, and leben usually fights 3 times a year. so he'll be making at least $75K and at most,150K… excluding the endorsements he gets, the ladies he gets, and his trainer job in hawaii.
he is a tough guy and always puts on a show i am glad they resigned him now they need to resign aa.
I think they should give him $30,000 a fight because he is a streaky fighter who goes through 3 wins then 3 losses…but im glad he's getting a raise
Stay in the UFC where the competition's a little easier!
competition easier? haha. best one i heard all night. tell that to fedor! what other big names are there in m1? chris leben has anderson silva, dan henderson, rich franklin… and possibly a sober evan tanner in the 185 divison.
hell yeah thats my boy
Don' forget guys last time leben talked shit about those "other guys in japan or whereever their from" he got his knocked the fukkkeedd out by the Spider "baby".
if leben uses all of his skills he should have no problem but if he stands and bangs with this guy he is giving him a better chance to win.


text:
Whacky Rhythms for Your Cocktail Hour(s)
Pop, Psychedelic, and a sprinkling of Motown from the years 1965-1970. You'll get hits, misses, garage bands, Bubblegum, Motown, and everything in between. RARE MONO single versions, and RARE LIVE tracks from the artists in their prime...
Miscellaneous Oldies Songs selected for your pleasure by NitroNerd...
Best 60/70s oldies Music you've never Heard/We don't play the hits either/GARAGE/BRITISH/PSYCH/
Just started a facebook page. Search for cromrockradio and 'like' it. Slowly making a band list in info and will post updates. Cheers fuckers!
♫ Jamaican Ska ♫ Rocksteady ♫ Skinhead Reggae ♫ 2-Tone and more! ♫ Music from the early days of ska and rocksteady, today's sound, and everything in between! ♫
AIR ATLANTIC UNDERGROUND: Filling the spaces between your ears mixed with Underground vibrations such as Shoegaze, Psychedelic, Dream, Bliss, Drone, Brit, Trip Hop, Ambient, Electronica, Indie, Rock & other flights of fancy.
Take A Spacey Trip Back In Time To An Era Of Great Unknown Bands And Rare Recordings Of Farout Psychedelic Music.
In The Red Radio is hosted by In The Red Records' founder Larry Hardy. Once a month he presents an audio avalanche of the best, wildest and weirdest in garage, punk, post-punk and all manner of eccentric rock & roll music.
Music for your Lounge, Elevator or Stylish Bachelor or Bachelorette Pad....Swing on Over!! Great for Work - it's definitely Shaken, Not Stirred!!
Classic and progressive rock from '65-'75 . Pink Floyd, Led Zeppelin, Beatles, Rolling Stones, Hawkwind, Jefferson Airplane, Genesis, David Bowie, Cream, Doors, Yes, Fleetwood Mac, Traffic, Byrds, Who, Jimi Hendrix, Todd Rundgren, Moody Blues, etc.
Now.Playing, OccuPatriotic, Varous tunes to build new worlds by...Not employed @Live365. I pay monthly 2 stream. Please Support R Sponsors when possible! %of adfreeVIPsubs reduce my expenses. Thanx!
Cruisin' Songs & Full Throttle Hits! Music is an essential part of the Car Kulture and Custom Motorcyclers life! After all its the beat that sets the pace! This station is for those who love music with a Hot Rod attitude. Host Oldies DJ Rudy The "K
Dark Cabaret, Circus Noir, Gypsy Punk, Carnivale, Southern Gothic and Funeral Ballads
An eclectic mix of rock, jazz, reggae, surf, lounge and more coming at you from the wilds of suburban New Jersey. Like the Rock 'n' Roll Jazz Lounge on Facebook at http://www.facebook.com/rocknrolljazzlounge
Groovy Psychedelic 60's. The best of the known and unknown in America and Britain. Trip the light fantastic baby with the Dead, Kinks, The Seeds, and Mystery Trend amongst other weirdos.


text:
Mon-Fri: 7am-1am EST / Sat-Sun: 7am-11pm EST
ApplianceMaytag Dishwasher
Level of DifficultyA Bit Difficult
Time to do repair30 - 60 mins
Age of ApplianceMore than 10 years
NutdriverPliersScrew driversSocket setWrench setWrench(Adjustable)
I changed all of the switches first because it looked easier than the fill valve under the unit. After all of the switch changes (which were simple and quick) the washer still didn't fill. I removed the water valve and cleaned it, but still wouldn't fill. I reinstalled the old valve for practice, and then ordered water valve. It went alot smoother the second time around. I found it easier to disconect and connect the rubber water line with the hose clamp if I removed the valve from the sidewall of the wahser. Easier to get my fat fingers where they nedded to be. Used a shallow round 1 layer cake pan to catch drips. Works gtear now, and since I had earlier replaced the racks and silverware basket, it's pretty much a "new" twenty year old dishwasher. I went with the rehab instead of just replacing it because it has wood front panels which match our cabinets and wouldn't fit a new unit.
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Part Number: PS2098991
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text:
The Warriors won the right to host the play-off when they beat Zebre 54-0 at Scotstoun on Saturday, a result that meant they finished second in the PRO12 table. Around 600 tickets were sold at the ground immediately after the match, and plans were announced for a general sale to commence tomorrow morning.
However, with around 2700 season ticket holders having priority rights, and 2500 seats allocated to the away team, the number that can go on sale is already seriously diminished. On top of that, on Saturday evening the SRU sent out more than 100,000 emails to existing customers who have bought tickets - even if only for games at Murrayfield - in the past. A positive response rate of as little as five per cent would mean there would be no tickets left by tomorrow.
"That is certainly a possibility," said an SRU spokesman. "There is definitely the potential for a sell-out before Tuesday."
There have also been complaints from rugby followers who have tried to use the SRU's system that only uncovered seats seemed to be available for Friday's game. Others, though, have pointed out that Munster's allocation is being sold by online retailer Ticketmaster, and there are no restrictions on Scottish fans buying tickets by that route.
The spokesman confirmed that there are no plans to raise the semi-final capacity to 15,000 by re-erecting the temporary stands that were used for the Emirates Airline 7s the weekend before last. However, it is understood that these stands could be brought back if Glasgow earn the right to host the final on May 31.
For that to happen, the Warriors would clearly have to beat Munster on Friday, but Ulster would also have to win against Leinster in Dublin the following day. Having finished higher than Ulster in the league, Glasgow would be awarded home advantage for the final.


text:
I was sitting on the bed while Secret was lying there in her skirt. I was curious to know what panties she had on under her skirt so I decided to take a peek. What I saw was so sexy that I had to snap a few pics with my phone.
Welcome Nside Our SecretThis blog chronicles the Erotic Journal of a Married Couple
Under her Skirt
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Page 1
2007;67:6017-6021. Cancer Res
Cecilia Garlanda, Federica Riva, Tania Veliz, et al.
Receptor Family
Lacking TIR8, an Inhibitory Member of the Interleukin-1
Increased Susceptibility to Colitis-Associated Cancer of Mice
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Page 2
Increased Susceptibility to Colitis-Associated Cancer of Mice
Lacking TIR8, an Inhibitory Member of the Interleukin-1
Receptor Family
Cecilia Garlanda,
Enrico Radaelli,
Eugenio Scanziani,
1Federica Riva,
2Marina Sironi,
2and Alberto Mantovani
2Tania Veliz,
1Manuela Nebuloni,
1Nadia Polentarutti,
3Elisabetta Omodeo Zorini,
1Fabio Pasqualini,
1Istituto Clinico Humanitas (IRCCS), Rozzano, Italy;
''L. Sacco'' Department of Clinical Sciences, and
2Department of Animal Pathology, Faculty of Veterinary Medicine,
4Institute of General Pathology, Faculty of Medicine, University of Milan, Milan, Italy
3Pathology Unit,
TIR8 (also known as SIGIRR) is a member of the interleukin-1/
Toll-like receptor family with inhibitory activity on inflamma-
tory reactions and high expression in intestinal mucosa. Here,
we report that Tir8-deficient mice exhibited a dramatic
intestinal inflammation in response to dextran sulfate sodium
salt (DSS) administration in terms of weight loss, intestinal
bleeding, and mortality and showed increased susceptibility
to carcinogenesis in response to azoxymethane and DSS.
Increased susceptibility to colitis-associated cancer was
associated to increased permeability and local production
of prostaglandin E2, proinflammatory cytokines, and chemo-
kines. Thus, these results are consistent with the hypothesis
that TIR8, by negatively regulating intestinal inflammation,
plays a nonredundant role in the control of the protumor
activity of chronic inflammation in the gut. [Cancer Res 2007;
Several lines of evidence, based on epidemiologic studies as well
as animal models, are consistent with the view that chronic local
inflammation plays an important role in malignant progression
(1–3). The inflammatory environment of tumors is characterized
by the presence of mediators and cells that act as tumor promoters
(1). Soluble mediators such as cytokines, chemokines, enzymes, and
growth factors are released by tumor cells and stromal cells and are
responsible of leukocyte recruitment in the tumor environment,
survival, and differentiation. Leukocytes infiltrating the stroma, in
particular tumor-associated macrophages, promote tumor prolif-
eration and progression, stroma deposition and remodeling, and
angiogenesis and inhibit effective antitumor T-cell–dependent
immunity (1, 4). A pivotal role in these pathophysiologic processes
is played by the transcription factor nuclear factor nB (NF-nB),
which has dual functions in promoting tumor growth. NF-nB
activated in inflammatory cells in response to microbial stimuli,
inflammatory cytokines, and danger signals released by necrotic
cells regulates the production of cytokines, chemokines, and growth
and angiogenic factors; in tumor cells, activation of NF-nB leads
to the production of cell cycle genes, antiapoptotic genes, and inva-
sive proteases (5–7).
The activation of the signaling cascade leading to NF-nB
activation by interleukin-1 receptors (IL-1R) and Toll-like receptors
(TLR) is tightly regulated at different levels, extracellularly and
intracellularly, and more than 20 pathways of negative regulation of
IL-1R/TLR signaling have been described (8, 9).
The IL-1R family member TIR8 (also known as single immu-
noglobulin IL-1R-related molecule, SIGIRR), an orphan receptor,
inhibits signaling from the IL-1R/TLR complexes, possibly by
trapping IRAK-1 and TRAF-6 (8, 10). TIR8 is characterized by the
presence of a single immunoglobulin domain in its extracellular
region, a conserved TIR domain, and a 95-amino-acid long tail with
inhibitory properties (11, 12). TIR8 is expressed in several tissues,
especially in the digestive tract, and cell-type expression is parti-
cularly high in epithelial cells (12, 13). Accordingly, there is evi-
dence for a nonredundant regulatory role of this molecule in
inflammation involving the gastrointestinal mucosa (13).
Colitis-associated cancer is a colorectal disease that arises in
patients suffering from chronic inflammatory bowel disease, in
particular ulcerative colitis (14). In mice, colitis-associated cancer
can be induced by injection of the procarcinogen azoxymethane,
followed by three cycles of exposure to dextran sodium sulfate
(DSS; ref. 15), which causes chronic inflammation, mimicking
inflammatory bowel disease.
Given the regulatory role of TIR8 in the intestinal tract, it was
important to assess its potential involvement in colitis-associated
cancer. Here, we report that Tir8 deficiency resulted in increased
susceptibility to colitis-associated cancer, which was associated to
higher local production of proinflammatory cytokines and chemo-
kines. These results strongly support the hypothesis that TIR8 plays
a nonredundant, tuning role in gastrointestinal inflammation–
associated cancer and underline its potential as target for cancer
prevention and therapy.
Materials and Methods
Animals. Tir8-deficient (Tir8?/?) mice were generated as described (13).
Mice used were 8 to 12 weeks old on a mixed (C57BL/6J ? 129/Sv) or inbred
(backcrossed for 11 generations with C57BL/6J) background. Littermates
of Tir8?/?mice or C57BL/6J obtained from Charles River Laboratories
were used as wild-type controls (Tir8+/+). Mice were housed in the specific
ventilated cage systems. Procedures involving animals and their care
conformed with institutional guidelines in compliance with national (4D.L.
N.116, G.U., suppl. 40, 18-2-1992) and international (EEC Council Directive
86/609, OJ L 358,1,12-12-1987; NIH Guide for the Care and Use of Laboratory
Animals, U.S. National Research Council 1996) laws and policies. All efforts
were made to minimize the number of animals used and their suffering.
Note: C. Garlanda, F. Riva, and T. Veliz contributed equally to this study.
Requests for reprints: Alberto Mantovani, Istituto Clinico Humanitas, Via Manzoni
56, 20089 Rozzano, Italy. Phone: 39-2-8224-2444; Fax: 39-2-8224-5101; E-mail:
I2007 American Association for Cancer Research.
Cancer Res 2007; 67: (13). July 1, 2007
Priority Report
on June 4, 2013. © 2007 American Association for Cancercancerres.aacrjournals.org Downloaded from
Page 3
Azoxymethane/DSS–induced colon cancer. To induce colon tumors,
mice were treated, as described (15), with a single dose (10 mg/kg) of the
mutagenic agent azoxymethane (Sigma) followed by three cycles of 3%, 2%,
or 1.5% DSS (molecular mass, 40 kDa; ICN) dissolved in sterile, distilled
drinking water, resulting in a 60-day experimental period. At the end of
treatment, mice were sacrificed for histologic analysis of the intestine. For
cytokine production analysis, animals were sacrificed at the end of the first
DSS cycle. The determination of clinical scores was done as described (13).
Histologic analysis. The large intestine was removed, rolled up, fixed in
10% neutral bufferedformalin, and embedded in paraffin. H&E-stained serial
tissue sections were used for pathologic evaluation in a blinded fashion by a
pathologist (E.S.). Proliferative and neoplastic lesions were classified as gas-
trointestinal intraepithelial neoplasia, low-grade and high-grade adenoma,
or adenocarcinoma. The area of each proliferative lesion was determined
with an image analysis software (Win Roof, version 3.6, Mitani).
Immunohistologic analysis. Eight-micrometer-thick consecutive frozen
sections were cut and mounted on Superfrost slides (Bio-Optica). Immu-
nohistochemistry was done with the following antibodies: biotinylated anti-
CD68 monoclonal antibody (mAb; clone FA-11, HyCult Biotechnology),
rabbit anti-human/mouse CD3 polyclonal antibody (DakoCytomation), rat
anti-mouse/rat FoxP3 mAb (clone FJK-16s, eBioscience), and rat anti-mouse
CD8 mAb (BD Biosciences PharMingen). Secondary antibodies used were
Envision+ System-horseradish peroxidase (HRP)–labeled polymer (anti-
rabbit; DakoCytomation), biotinylated antirat immunoglobulin G (Vector
Laboratories), and ZyMax streptavidin-HRP conjugate (Zymed). The chro-
mogen was 3,3¶-diaminobenzidine–free base. A quantitative evaluation of
immunostaining was applied using WinRec Programme (Image Pro Plus)
by counting immunopositive cells per field at ?20 magnification.
Whole colon organ culture and colon tissue lysate. Colon segments
(100–200 mg of tissue) were washed in cold PBS supplemented with
penicillin and streptomycin and either homogenized in PBS containing
protease inhibitors cocktail Complete (Roche Diagnostic) and stored at
?80jC or cultured in 24-well flat-bottomed culture plates in RPMI 1640 with
0.1% FCS. After incubation at 37jC for 24 h, supernatants were centrifuged
at 13,000 rpm at 4jC for 5 min and stored at ?80jC until analyzed.
ELISA. Murine cytokines and chemokines (IL-6, tumor necrosis factor a,
IL-1h, IL-10, IFNg, KC/CXC, JE/CCL2, and MIP1a/CCL3) were measured in
whole colon culture supernatants and colon tissue lysates by ELISA (R&D
DuoSet ELISA Development Systems). The sandwich ELISA for PTX3 was
done with the anti-murine PTX3 mAbs 2C3 and 6B11. Prostaglandin E2
(PGE2) was measured by enzyme immunoassay (Cayman Chemical
Company). Levels were standardized to the content of total protein by
quantification by bicinchoninic acid analysis (Pierce) and presented as
nanograms or picograms of cytokine per milligram of protein.
Evaluation of colonic epithelial permeability. Colonic epithelial
permeability was assessed by the penetrance of Evans blue (Sigma) from
the lumen into the wall of colon on day 7 after administration of 2% DSS as
described (16).
Statistical analysis. Six to 15 animals per experimental group were used
throughout the study. Data are expressed as mean F SE or SD and one-
tailed or two-tailed Student's t test was used as specified. P V 0.05 was
considered significant. Experiments were repeated two to five times.
Deletion of Tir8 does not perturb normal gastrointestinal
development, morphology, or function in nonchallenged mice.
Analysis of body weight, intestinal histology in terms of
morphology and number of lymphoid follicles at different time
points (2, 6, 10, and 12 months of age), and cytokine and
chemokine production at the intestinal level in untreated mice did
not reveal differences between Tir8?/?and Tir8+/+mice on both
genetic backgrounds examined (C57BL/6 and C57BL/6x129/Sv;
data not shown). These results suggest that, under homeostatic
conditions in the absence of epithelial barrier erosion, Tir8
deficiency is not sufficient to result in spontaneous intestinal
inflammation triggered by endogenous intestinal flora.
To assess the role of TIR8 in colitis-associated cancer, the
protocol of a single azoxymethane injection followed by three
Figure 1. Increased acute and chronic
intestinal inflammation in the absence of
Tir8. A, mortality of mice on C57BL/6
background fed with DSS as indicated
by the bottom bars (3% for three cycles or
with 2% the first cycle and 1.5% for the
following two). N = 10 for the 3% DSS
protocol and N = 15 for the 2% to 1.5%
protocol. Percentage of weight loss (B) and
bleeding score (C) in C57BL/6 mice fed
with 2% to 1.5% DSS. **, P < 0.001;
*, P < 0.05. D, colonic epithelial
permeability to Evans blue expressed as
absorbance at 620 nm per gram of colon
tissue in basal conditions and on day 7
after administration of 2% DSS.
Cancer Research
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Page 4
cycles of DSS for 7 days and normal drinking water for 14 days was
applied. Mice treated only with azoxymethane did not develop
tumors during the observation period, suggesting that in the
absence of induced inflammation, Tir8 deficiency per se does not
increase susceptibility to cancer development.
As shown in Fig. 1, the protocol of colitis-associated cancer
resulted in dramatic susceptibility to colon inflammation in
Tir8?/?mice compared with Tir8+/+mice, with high rate of mor-
tality associated to intestinal bleeding and weight loss, in particular
in mice on C57BL/6 background, a more susceptible strain to
DSS-induced colitis than 129/Sv. In C57BL/6 Tir8?/?mice fed with
3% or 2% to 1.5% DSS, mortality was 100% in 10 days or 80% at the
end of the experimental period, respectively, compared with 30% or
14% in Tir8+/+mice (Fig. 1A). In Tir8?/?mice treated with 2% to
1.5% DSS, the body weight loss was 26.5% at day 10 and 11% at
day 50, compared with 7.8% and +3%, respectively, in Tir8+/+mice
(P < 0.001 and P < 0.05 at the two time points; Fig. 1B). Bleeding
scores were more severe in Tir8?/?mice throughout the period
analyzed (Fig. 1C). In mice on a mixed background fed with 3%
DSS, mortality was 33% in Tir8?/?mice and 20% in wild-type
littermates at the end of the experimental period, and the clinical
scores, in terms of body weight loss and in particular of intestinal
bleeding, were less severe (data not shown).
The permeability to Evans blue albumin was used as an index
of colon epithelial permeability. Colonic epithelial permeability to
Evans blue was significantly increased in Tir8?/?DSS-fed mice
compared with Tir8+/+mice (P = 0.001; Fig. 1D).
As shown in Fig. 2A, which reports results obtained in mice on a
mixed background fed with 3% DSS at the end of the 60-day
experimental period, the deficiency of Tir8 significantly increased
the incidence of tumors (P = 0.007). When the severity of lesions
was examined, a significant difference was also observed in the
number of gastrointestinal intraepithelial neoplasia (P = 0.01) and
of low-grade adenomas (P = 0.04), but not of high-grade adenomas
(P = 0.3). Although there was no difference in incidence, high-grade
adenomas tended to be bigger in Tir8?/?mice (2.67 F 0.8 versus
1.72 F 0.28 mm2). Given the high susceptibility of C57BL/6 mice to
DSS-induced colitis, a modified protocol was used (2% in the first
cycle and 1.5% in the following two cycles or 1.5% for three cycles)
with increased incidence of lesions, mostly low-grade adenomas in
Tir8?/?mice (P = 0.01; data not shown).
Similarly to ulcerative lesions, most of the proliferative lesions
were in the distal colon and rectum, projecting into the lumen,
and eventually almost completely obliterating the rectal lumen
(Fig. 2B–D).
To address the mechanisms underlying increased susceptibility
to inflammation and colon cancer in Tir8-deficient mice, NF-nB–
regulated genes encoding proinflammatory factors involved in
colon inflammation and tumor growth were measured by ELISA
in lysates and supernatants of colon segments collected from mice
at the end of the first DSS cycle. As shown in Table 1, increased
levels of IL-1h, IL-6, transforming growth factor h (TGFh), and
of chemokines JE/CCL2, KC/CXC, and MIP1a/CCL3 were observed
in colon homogenates from Tir8?/?mice compared with wild-
type littermates. Similar results were obtained when supernatants
from colon specimens were considered (22 F 4 and 38 F 5 ng/mg
KC/CXC in Tir8+/+and Tir8?/?mice, respectively). In addition,
IL-10 and PGE2 levels were higher in Tir8?/?supernatants
(P = 0.01). Interestingly, a significant decrease of IFNg in Tir8?/?
supernatant was observed (4.2 F 4.2 versus 25 F 7 pg/mg in
controls; P = 0.01).
Finally, tumors arising in Tir8?/?mice were investigated in
terms of leukocyte infiltration (Fig. 3). The leukocyte infiltrate of
Tir8?/?tumors was characterized by a more prominent infiltration
of CD68+cells (P = 0.01) and, intriguingly, of FoxP3+regulatory
T cells (P = 0.01; Fig. 3A and B). The percentages of FoxP3+cells
over CD3+cells were 54% and 85% in Tir8+/+and Tir8?/?tumors,
Figure 2. Increased colon carcinogenesis in the absence of Tir8. A, number of
total proliferative lesions per animal in C57BL/6x129/Sv mice at the end of the
treatment with azoxymethane and three cycles of 3% DSS and number of lesions
divided according to severity in gastrointestinal intraepithelial neoplasia (GIN)
and low-grade (Low) and high-grade (High) adenomas. N = 6 Tir8?/?and 9
Tir8+/+. B, sub-gross examination of H&E-stained sections reveals the presence
of high-grade (asterisk) and low-grade (circle) adenomas projecting into the
lumen concentrated along the rectal mucosa in a Tir8+/+mouse and the presence
of numerous high-grade adenomas and a single low-grade adenoma almost
completely obliterating the rectal lumen in a Tir8?/?mouse. C, microscopic
aspect of a low-grade adenoma in Tir8+/+mice and of a high-grade adenoma
in Tir8?/?mice (H&E, ?200). D, microscopic aspect of a healing ulcer
characterized by mild inflammatory changes in Tir8+/+and an active ulcer
characterized by a severe suppurative process in Tir8?/?(H&E, ?100).
TIR8 and Colitis-Associated Cancer
Cancer Res 2007; 67: (13). July 1, 2007
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respectively, whereas the percentages of CD8+cells over CD3+cells
were 28% and 8% in Tir8+/+and Tir8?/?tumors.
Colon carcinoma represents a paradigm for the connection
between inflammation and cancer (6). The present study was
designed to explore the regulatory role of TIR8, an inhibitory
member of the IL-1/TLR family, on intestinal carcinogenesis.
Results obtained confirm and extend previous observations on
the increased susceptibility to intestinal inflammation of Tir8-
deficient mice. Moreover, Tir8-deficient mice showed increased
susceptibility to carcinogenesis in response to azoxymethane
and DSS.
Activation of NF-nB has been reported in epithelial cells and
macrophages from inflammatory bowel disease patients as well as
in colon cancers, and anti-inflammatory therapy with inhibitors of
cyclooxygenases and NF-nB signaling pathway reduces the risk of
colitis-associated cancer (1, 6). TIR8 acts in vitro and in vivo as a
negative regulator of NF-nB activation in response to TLR and IL-
1R agonists (10, 13). In the present study, Tir8-deficient mice
showed increased production of prostaglandins, inflammatory
cytokines (e.g., IL-1 and IL-6), and chemokines (KC/CXC, JE/CCL2,
and MIP1a/CCL3) downstream of NF-nB. These have been shown
to promote inflammation-propelled neoplasia, in particular in the
gastrointestinal tract (6, 15). For instance, chemokines produced by
tumor cells and by recruited leukocytes influence the extent and
phenotype of leukocyte infiltrate, tumor cell and endothelial cell
growth and migration, and, finally, are involved in recruiting
polarized T helper 2 cells and T regulatory cells (17). In particular,
CXC chemokines mediate angiogenesis downstream of prostaglan-
dins in colon cancer (18, 19).
A predominant T helper 2 inflammatory response has been
implicated in colon cancer and IFNg deficiency increased the
frequency of colonic neoplasms (20). The low levels of IFNg
observed in Tir8?/?colons could be indicative of a T helper 2
polarized environment. Higher levels of IL-10 and TGFh, associated
to higher FoxP3+regulatory T-cell infiltrate in the tumors of Tir8-
deficient mice, possibly reflect the development of an immunosup-
pressive response inhibiting effective antitumor T-cell–dependent
immunity (17).
The results presented here show that TIR8 acts as a negative
regulator of intestinal inflammation and inflammation-promoted
Table 1. Inflammatory mediators in colon lysates from
DSS-fed mice (N = 8)
(pg/mg protein)
(pg/mg protein)
8.58xF 1.79
19.45xF 3.6
*Values are presented as mean F SE.
cUnpaired one-tailed Student's t test was used.
bMeasures were done in supernatants.
xPGE2values are in nanograms per milligram of protein.
Figure 3. LeukocyteinfiltrationinTir8+/+andTir8?/?tumors.A, immunostainingfor
CD68+(magnification, ?20), CD3+(?20), FoxP3+(?40), and CD8+(?20) cells.
B, numberofcellsperfieldinfiltratingTir8+/+andTir8?/?tumorsofsimilardimension
and severity. Columns, mean from the whole tumor areas, corresponding to 8 to
24 fields and 18 to 30fields at?20magnification,from threeTir8+/+and two Tir8?/?
mice, respectively; bars, SE. Unpaired two-tailed Student's t test.
Cancer Research
Cancer Res 2007; 67: (13). July 1, 2007
on June 4, 2013. © 2007 American Association for Cancer cancerres.aacrjournals.org Downloaded from
Page 6
carcinogenesis in mice. It will be important to assess whether
polymorphisms at the TIR8 locus impinge on human colon cancer
and whether TIR8 can be a target for pharmacologic intervention.
Received 2/9/2007; revised 3/13/2007; accepted 4/5/2007.
Grant support: Sixth Research Framework Programme of the European Union
(Projects NoE MUGEN LSHB-CT-2005-005203 and INNOCHEM), Ministero dell'Istru-
zione, Universita ` e della Ricerca (project FIRB and ''Piano Nazionale Ricerche-
Biotecnologie Avanzate, tema 2''), Fondazione CARIPLO (project Nobel), and the
Italian Association for Cancer Research.
The costs of publication of this article were defrayed in part by the payment of page
charges. This article must therefore be hereby marked advertisement in accordance
with 18 U.S.C. Section 1734 solely to indicate this fact.
We thank M. Necci and M. Tironi for photographic editing, S. Vetrano for technical
assistance, and S. Danese for helpful discussions.
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TIR8 and Colitis-Associated Cancer
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The Big Easy just got easier. Now you can enjoy the great taste of Zatarain's Red Beans and Rice with seasoned chicken and shredded cheddar cheese – from the freezer to your table in just minutes.
Cooked Long Grain Rice, Water, Rotisserie Seasoned Chicken Tenders (Chicken Tenders, Water, Rotisserie Seasoning [Salt, Sugar, Spices {Including Red Pepper And Paprika}, Soy Protein Isolate, Modified Potato Starch, Sodium Phosphate, Corn Starch, Carrageenan, Extractives Of Oregano, Soy Lecithin, Extractives Of Paprika, Garlic, Natural Flavor]), Dried Red Beans, Cheddar Cheese (Pasteurized Milk, Cultures, Salt, Enzymes, Annatto [Color]), Onions, Refined Lard (Lard And Partially Hydrogenated Lard, Bha, Propyl Gallate, And Citric Acid Added To Protect Flavor), Enriched Wheat Flour (Wheat Flour, Iron, Niacin, Thiamine Mononitrate, Riboflavin, Folic Acid), Sugar, Green Bell Peppers, Margarine (Liquid And Hydrogenated Soybean Oil, Water, Salt, Vegetable Mono And Diglycerides, Soy Lecithin, Natural And Artificial Flavor, Bha & Bht Added To Protect Flavor, Vitamin A Palmitate And Vitamin D3 Added), Yeast Extract, Smoke Flavor (Torula Yeast, Smoke Flavor), Canola Oil, Ham-Type Flavor (Soy Sauce [Hydrolyzed Soy Protein, Corn Syrup Solids, Salt], Yeast Extract, Maltodextrin [From Corn], Natural Flavors [Including Smoke], Soybean Oil, Spices), Dried Red And Green Bell Peppers, Celery, Toasted Onion Powder, Sugar, Spices, Granulated Garlic, Sea Salt, Sprouted Wheat Flour, Dextrose, Soybean Oil, Paprika, Disodium Inosinate And Disodium Guanylate (Flavor Enhancers).
1 bowl (283g)
(Amount per serving)
wish it was available everywhere. especially in Oklahoma City
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Pete Seeger Passes Away; Hank Cochran Gets Mississippi Country Music Trail Marker; New Album Releases
- Pete Seeger passed away yesterday at the age of 94. According to a CNN article, his grandson said that Seeger had been in the hospital for six days prior to his death and couldn't speak for the last three days, "but his mind never went away."
- The late Hank Cochran is being honored with a marker on the Mississippi Country Music Trail. Like all of the trail markers, Cochran's was written by our Barry Mazor.
- Willie Nelson tells Billboard that he, Kris Kristofferson, and Merle Haggard have a new album in the works.
- Check out Jon Langford's new song, "Mars." It'll be on his next record with Skull Orchard, Here Be Monsters (out April 1).
- From The A.V. Club: "Charlie Daniels' 'The Devil Went Down to Georgia' is a Southern Allegory." Last night, Daniels tweeted that his next record will be released in early April.
- Is 2014 the year Ronnie Milsap gets inducted into the Country Music Hall of Fame? The release of Milsap's new record, Summer #17, which was originally scheduled to come out today, has been pushed back to March 18. (via press release)
- Stream Robert Ellis' The Lights From the Chemical Plant, Parker Millsap's self-titled debut, and Vari-Colored Songs, Leyla McCalla's salute to Langston Hughes.
- Lyle Lovett, Garth Brooks, and Blake Shelton will appear on Jay Leno's final episodes of The Tonight Show next week.
- The 2014 ACM Awards nominees will be announced tomorrow morning. This year's awards show, scheduled for April 6, will be hosted once again by Blake Shelton and charisma vacuum Luke Bryan.
- Jody Rosen on Eric Church and new album The Outsiders: Church's records are the most sonically distinctive in commercial country, balancing rootsy earthiness and digital snap, with a muscled-up rhythm section that is more rock than country—and more classic heavy-blues-rock than the eighties arena-rock that's the current Nashville norm. Credit for the sound goes to Church and Jay Joyce, a Nashville-based guitarist and studio musician who has produced all of Church's albums. Joyce is a masterful record-maker, one of the great unsung talents in today's pop. He is, you might say, the Timbaland to Church's Missy Elliott; together, they're assembling a body of work that expands country's sonic palette while honoring the genre's core values of structure and storytelling—cooking up a feast for the ears while making sure that sound never trumps song. Church and Joyce are excellent arrangers with a knack for eccentric touches.
- Shovels & Rope helped J. Roddy Walston & The Business remake "Boys Can Never Tell." (warning: autoplay)
- The Bluegrass Underground won several Mid-South Regional Emmys over the weekend. The Special Event Coverage Award went to the 2012 Americana Music & Awards show.
- In the 1990s, somebody — perhaps multiple somebodies — at Marvel Comics thought that publishing a Billy Ray Cyrus comic book was a good idea. The "48-page masterpiece of madness…featured the country music star and future terrible father traveling through time to fight ghosts, dragons, and evil knights, with nothing but the greatest mullet that has ever been featured in the comics medium."
- Stephen Deusner looks at Uncle Tupelo's legacy and speaks with Jay Farrar for American Songwriter. Annie Zaleski of The A.V. Club asks if No Depression lives up to its reputation (spoiler: it does).
- CMT Edge premiered the video for Rob Picott's "65 Falcon."
- Conan O'Brien poked fun at Taylor Swift's headbanging Grammy performance.
- The Americana tribute to Phil Everly held in L.A. last weekend sounds like it was an excellent night of music.
- Go Down Moses has signed with Sony Music Nashville.
- This week's album releases (thank you for supporting Engine 145 by purchasing your music through the affiliate links below):
Vince Gill & Paul Franklin – Bakersfield (Deluxe Edition)
Farewell Drifters – Tomorrow Forever
Laura Cantrell – No Way There From Here
Rhonda Vincent – Only Me
Gangstagrass – Broken Hearts and Stolen Money
Uncle Tupelo – No Depression: Legacy Edition
The Moonshine – And Now…
David Crosby – Croz
Amy Ray – Goodnight Tender
Leif Vollebekk – North Americana
Marshall Tucker Band – Live at Raceway Park, 9/3/77
Billy Joe Shaver – The Complete Columbia Recordings ('81-'87)
5 Comments
That Conan take on Taylor Swift's body motions at the Grammy's seems perfectly reasonable to me. It would also explain the quality of her vocal performance as well…
If Eric Church recorded an "unplugged" album, I'd probably wind up downloading a track or two. His acoustic performances on the Opry are always top notch, whereas I can't stand his typical electric sound (which is definitely not targeted for old farts).
Article title above: "The Americana tribute to Phil Everly held in L.A. last weekend sounds like it was an excellent night of music." Thanks for rubbing that in…(lol)
Speaking of "Gangstagrass" the new season of "Justified" on FX has been short on country and Americana music! Come to think of it "Hart of Dixie" has also stopped featuring country artists (excluding cast member Laura Bell Bundy) and ABC's Nashville rarely features cool bands in the background any longer. What's up with that?
Jeez, I was waiting with bated breath for the Rick eulogy to Pete Seeger. What happened?
Then I will say something LuckyOldSun. Pete Seeger was a great American. Some Americans take and take, and some give and take, and some just give. Pete Seeger was a giver of songs, history, courage, and honesty. He was one of our last links to Woody and Leadbelly. And he never failed to remind us that protest is a real and living freedom, and that each of us has something great to give to our blessed homeland. Whether you agree with his politics or not( I didn't always agree)at least he represented what makes us unique in the history of the world:our ability to speak up, without fear, to power, to each to other, and to our own being.
Yes, ditto, Craig!
Current Discussion
- Paige: Oh damn. :( I never commented here and I haven't been listening to any music at all since Thanksgiving (it …
- Dave W.: Just read the news here. Will miss E145 very much - love this site. All the best to you Juli …
- Leeann Ward: Oh, dang! This is real. Farewell to the most generous, informative, quality, intelligent, consistent, ethical country music blog! You …
- bll: Thanks Juli for all the great articles and information; you'll be missed by me and I suss several others. Best …
- Both Kinds of Music: I hope people appreciate the irony that one of the best "Americana" albums is titled Metamodern Sounds in COUNTRY Music.
- Barry Mazor: I would not rule out that possibility..There's a different set of voters involved..
- Dana M: Does anyone else think that Brandy Clark actually has a good chance of winning since this isn't a country awards …
- Juli Thanki: UPDATE: Brandy Clark got a Best New Artist nom. BEST AMERICANA ALBUM: Rosanne Cash -- The River & The Thread John Hiatt -- Terms …
- luckyoldsun: Glenn Campbell is great and I'd love to see him get an award, but the words of that song may …
- Casey Penn: Juli, it was an honor to write for you here on Engine145.com. You're good at what you do, and The …


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Napier - The Crusaders will play their first Super Rugby "home" game of the next season against the Chiefs at McLean Park in Napier on March 9, the Christchurch-based team's chief executive Hamish Riach said on Thursday.
February's Christchurch earthquake forced the seven-times champions to play all their games away from home last year, incurring a massive loss of potential earnings, and the new stadium is not yet ready to host their first home match.
"Having lost NZ$700 000 ($563 900) last year, we are extremely conscious of the financial implications of all our decisions this year, and the extra return from playing at McLean Park is significant," Riach was quoted as saying on the Crusaders website (www.crusaders.co.nz).
"We played there last season and had fantastic support and we believe that support will be there again this year," he added.
While Napier promised better financial returns, Riach said it was not easy to overlook Timaru or Nelson.
"Both those cities gave us tremendous support last season and while we know there will be disappointment that we are not returning for a match in 2012, we hope our fans in those cities understand the reasons for the decision," Riach added.
The Crusaders open the season with two away fixtures, against the Blues in Auckland on Feb. 24 and the Highlanders in Dunedin on March 2, before facing the Chiefs in Napier.
Their next home game is against the Cheetahs on March 24 and is expected to go ahead as scheduled at Rugby League Park in Christchurch.
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Bulls - who lost 23-18 to the Blues in Auckland
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Cheetahs - who lost 45-24 to the Highlanders in Bloemfontein
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Bulls - who lost 23-18 to the Blues in Auckland
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text:
Hey there,
I just tried to upload a little halloween profile pic of my halloween look but it doesn't show up and the console throws 403 forbidden ––– whyyyy I mean, come on, it's not even THAT scary!
Does anyone else experience this or does anyone know what I can do?
I thought it was a ghost picture ;D
I've tagged for staff reply it happens quite a lot happened when I first started, try changing the format, eg, jpg to png and see if that works or rename?
New file on front page with same issue, could it be, server-pocalypse?!
Thanks FlatKing! Changing name or file type didn't work – I broke everything…
I'm sorryyyy Envato I didn't mean to break your system!!
I will never upload an image of such a diabolical costume again
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text:
Second, EAG believes it is unwise to view merit pay only as a carrot to be dangled in front of teachers, enticing them to perform better. Merit pay should be given to teachers who already perform better. Excellent teachers will be excellent teachers regardless of their compensation. Merit pay should simply reward them for their excellence and the positive results they produce. Pink slips should be given to those who don't produce positive results.
The study's authors write:
"The limited motivational effect of the bonus might have resulted from school staff viewing the award as a reward rather than an incentive: It made them feel appreciated for their hard work, but they claimed that they would have undertaken this work with or without the bonus."
If the bonuses made effective teachers "feel appreciated for their hard work," then EAG believes the value of merit pay is affirmed. No further study is required.
Merit pay proponents believe such bonuses work because they allow schools to recognize and honor effective teachers for their professionalism. EAG believes merit pay is an ideal way to elevate the education profession, and will help attract and retain top talent.
Teacher unions, on the other hand, refuse to acknowledge that teachers have various levels of talent and ambition. Instead, unions treat educators as interchangeable and indistinguishable workers – each one no better or no worse than the teacher down the hall. That's why the unions resist the concept of merit pay, and rejoice when studies such as this one get published.
Bottom line: The RAND study seems to use a debased concept of merit pay and may have a design flaw that makes its conclusions unconvincing.
EAG hopes additional social scientists review the study and clarify some of these questions before the report is enshrined as conventional wisdom.Until that happens, we hope the RAND study does not undercut many of the promising innovations that are being implemented in public schools nationwide.
Kyle is founder of Education Action Group and EAGnews.org, a news service dedicated to education reform and school spending research, reporting, analysis and commentary.
He is co-author of Glenn Beck's "Conform: Exposing the Truth About Common Core and Public Education," available at Amazon.com.
Kyle is a contributor to Townhall.com.
He has made appearances on the Fox News Channel, The Blaze, Fox Business Network, NPR and MSNBC. Kyle has given scores of interviews on talk radio programs coast to coast.
Kyle likes talking about his family, as well as his favorite music. Bob Dylan, Mark Knopfler, Neil Young and Johnny Cash are at the top of the list. He has attended 25 Bob Dylan shows.
Kyle can also be found on Facebook and Twitter.