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Elizabeth Arden Eight Hour Cream
442 reviews
64% would repurchase
Package Quality: 3.8
Price: $$$
Package Quality: 3.8
Price: $$$
INGREDIENTSPetrolatum 56.8%, Lanolin, Mineral Oil, Fragrance, Salicylic Acid, Propylparaben, Castor Oil, Corn Oil, Tocopherol, BHT, Iron Oxides
on 2/6/2013 4:19:00 PM
Age: 18 & Under
Skin: Combination, Fair-Medium, Warm
Hair: Blond, Wavy, Medium
Eyes: Grey
Well, it wasnt bad and I still use it but it just sits on the skin. Its good for this purpose to protect the skin but its not very hydrating in itself.
I have very dry and pigmented outer corners of my eyes, it looks weird and often simply hurts (esp. after makeup removal).
I used some ointments from pharmacy, some creams and serums and then I got a sample of this and omg finally something actually made difference!!
I dont like the smell, shine or consistency but it works and that what matters! I warm it up and then pat it on, I also used it on lips but for lips I prefer homeoplasmine. On cuticles it works great too. Sometimes I will put it instead of any eyeshadow and pair it with strong mouth- great look. I like the tube packaging too.
on 2/3/2013 5:22:00 PM
Age: 30-35
Skin: Sensitive, Fair-Medium, Not Sure
Hair: Blond, Other, Other
Eyes: Brown
This is an essential in my beauty cabinet - I love it! The best lip soother ever, lasts so much longer than other comparative products such as Vaseline. Also excellent for chapped or dry skin - just slather on affected areas in the evening and miracles appear to happen overnight! It's a little greasy and doesn't smell great (although I think there's now an unscented version available) but the results are fantastic! I stock up at duty free as find it's much cheaper than buying in the UK. Highly recommended!
on 2/3/2013 2:35:00 PM
Age: 25-29
Skin: Combination, Fair, Cool
Hair: Blond, Other, Other
Eyes: Blue
So, I could NOT find anything to soothe and smooth my dry, cracked lips and then this heavenly tube came my way....
I cannot praise this stuff enough for changing my lips in a drastic way. Its not meant for lips persay, but try it. It's thick, (I got the fragrance free btw), no smell, and lasts. I apply it quite alot, since I'm a smoker, and it has brought back my pretty pout! I have thrown out all other lip balms (which was a whole drawer, FYI).
If your lips are severly chapped and look like bird feathers instead of smooth, pick this up!
4 lippies because the tube stands about 6 inches high, so it's not throw in your clutch type lip treatment, but I don't care!
on 1/31/2013 12:05:00 PM
Age: 30-35
Skin: Dry, Medium, Warm
Hair: Brown, Wavy, Fine
Eyes: Brown
It feels and smells like industrial grease. Foul scent + too thick consistency to use anywhere other than lips or heels, and I don't feel like I have benefitted from it in any way.
on 1/16/2013 11:38:00 PM
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Blond, Other, Other
Eyes: Hazel
This product is awesome for someone who has dry patches or dry lips ! I mainly just use this cream in the winter . Even though I have combination skin my nose and lips still peel in the winter time . Before I go to bed I put a tiny amount on my nose and lips ( a little goes along way! ) when I wake up my lips are so soft and my nose is instantly smooth. The smell isn't that appealing but they just released a non scented version !! One tube will last you over 24 months, so it's a great value ! A must if your dry !
on 1/12/2013 1:51:00 PM
Age: 19-24
Skin: Combination, Medium, Not Sure
Hair: Black, Other, Other
Eyes: Black
I really like this product. I know some people say it is overpriced Vaseline but I think this works much better that than on dry skin. When I use it on cracker skin on my nose sometimes it resolves within a couple of days. I also use it on my lips overnight and they becomes really soft and look nice in the morning my lips are naturally very dry and chapped. It works much better than Vaseline on dry skin and it penetrates further into the skin and resolves the dryness whereas Vaseline doesn't. I also use this cream on my eyelids because they can become quite dry but it also looks nice and shiny in the day time.
on 1/5/2013 4:09:00 PM
Age: 25-29
Skin: Oily, Olive, Not Sure
Hair: Brunette, Curly, Coarse
Eyes: Black
I tried a sample of this at the counter on my hands only. I picked it up and almost bought it because it was such a great price! I'm so glad I tried it though.. the smell is horrid. I rubbed it into my hands and told the SA that it smelled expired. She smelled it and said "It's not expired, that's just how it smells." Fragrance free my size 12 ass.
No thank you. I guess they meant no fragrance added. The natural fragrance is musty. I'm kind of weird and I like an expired lipstick smell (yeah, yeah shoot me) but this was just gross.
I rubbed it into my hands anyway, went on with my shopping and really did not find it to be anything special. I like that it's a balm. It reminded me of Neutrogena's Norwegian Formula Deep Moisture Fast Absorbing Hand cream. I find theirs to be much more moisturizing.
Anyway, I washed my hands about an hour or so later (plenty of time for it to absorb) and my hands were totally dry again. No improvement... I didn't go back and buy this. I did see that there's an original Elizabeth Arden 8 hour cream on one of those discontinued cosmetics websites so maybe the old formula was much better?
If my review helped you, click yes below!
on 1/5/2013 10:24:00 AM
Age: 19-24
Skin: Acne-prone, Medium, Warm
Hair: Brunette, Wavy, Medium
Eyes: Brown
This stuff smells so bad!! I can't get over it! It smells like the inside of an old cabinet, like another reviewer said. It's like a mix of something herbal and musty at the same time. I thought that my bottle was old and that's why it smells like that but I guess it was intentional. I use it for my hands and it doesn't work for me. My hands get really dry in the winter months and so I need something that's intensive - that's why I grabbed this. So far, it sucks and I have to reapply every 15 minutes or so. Thankfully I got a small bottle and picked it up from Winners for really cheap. I can't imagine paying full price for this.
on 1/5/2013 1:08:00 AM
Age: 25-29
Skin: Very Oily, Olive, Not Sure
Hair: Black, Wavy, Fine
Eyes: Brown
I hesitated to buy this because it seemed like a lot for what it is. And while it's not cheap, I do think it's worth it for what I bought it for. It's a very cold, dry winter where I'm at, and my cuticles are constantly splitting and tearing because they're so dry. I've tried all different kinds of lotion, cuticle oil, aquaphor, everything- and still nothing would help. So I finally tried 8 hour cream, and it is the only thing that works. I haven't tried it anywhere else, and the only other place I'd really consider trying it is my lips. However, after I put it on my nails it leaves behind kind of an oily residue, and I just can't imagine that won't clog my pores and lead to blemishes/bumps around my lips. Plus, I use Smith's Rosebud Salve on my lips and love that, so I'm not willing to risk it. So, if you have extremely dry cuticles, this will work miracles, and if that's important to you, than you will probably consider this worth it.
on 12/25/2012 1:09:00 AM
Age: 19-24
Skin: Sensitive, Fair-Medium, Neutral
Hair: Blond, Straight, Fine
Eyes: Grey
Never would have thought I would have purchased what I told people was "glorified vaseline". Guess what? I WAS WRONG. I snagged a tube of this for only $7 at Marshals. Beats paying full price! The first week I only used it on my lips and cracked cuticles, which were super supple by the end of the week. I was hesitant to try on my face as it seems greasy-- but I did. And I'm glad I did. This stuff can heal my acne like a BOSS. I don't know how, but it does. The consistency looks like vaseline coming out of the tube, but as you rub it together it liquifies into an oil that is easily rubbed into any dry part of the skin.
At first I thought the smell was pretty off putting, but now I have come to enjoy it!! On my 2nd tube now! I'm a total convert!
I found a substitute for this that I feel is a bit better to wear on my face at night. I now use Mary Kay's extra emollient night cream. It's not as greasy or sticky so I don't feel so weird with it touching my pillow. I still wear the EA8 on my lips and will put it on the occasional breakout to help treat it.
Popular Treatments (Face)


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Paula McLain received an MFA in poetry from the University of Michigan and has been a resident of Yaddo and the MacDowell Colony. She is the author of two collections of poetry, as well as a memoir, LIKE FAMILY, and a first novel, A TICKET TO RIDE. She lives in Cleveland with her family.
Paula McLain

subset: commoncrawl


text:
Gum Disease Center - Roswell, NM
WebMD Physician Directory
Roswell, New Mexico
Gum Disease
What is gum disease (gingivitis)?
Gum disease, or gingivitis, is inflammation of the tissues surrounding and supporting the teeth and is most commonly a result of poor dental hygiene. Gingivitis is a very common condition and varies wide...
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Scotland fans can travel east
Scotland's fans will not be forced to cancel their travel plans for the vital European Qualifier in Georgia after UEFA backed down on a feared stadium ban.SkySports.com » 20m
Scotland's fans will not be forced to cancel their travel plans for the vital European Qualifier in Georgia after UEFA backed down on a feared stadium ban.SkySports.com » 20m
Ross County boss Jim McIntyre has made his second summer signing after snapping up Partick Thistle goalkeeper Scott Fox.SkySports.com » 51m
Facing Falkirk in the Scottish Cup final is the culmination of a "fantastic season," says Inverness CT assistant boss Russell Latapy.BBC Sport » 1h
Reported Celtic target Danny Wilson has left Hearts after activating a clause in his contract.SkySports.com » 1h
Motherwell are hopeful two of the players who helped them to victory against Rangers on Thursday can recover in time for the second leg this weekend.SkySports.com » 1h
Ross County sign Scott Fox on a two-year contract after the goalkeeper rejects a new deal with Partick Thistle.BBC Sport » 2h
Inverness are without Gary Warren for Saturday's Scottish Cup final against Falkirk at Hampden Park.SkySports.com » 2h
Stuart McCall is adamant Rangers will be ready to respond on Sunday when they face Motherwell again despite their 3-1 defeat to the Lanarkshire side on Thursday night.SkySports.com » 3h
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text: The Italian American Association of Luzerne County is holding its April dinner meeting at 6 p.m. on April 18 at the Genetti Hotel and Conference Center, Wilkes-Barre. Dinner will be served at 6:30 p.m. Price is $25 per person. Music for dancing will be provided by Danny Argo & Friends with dancing to 10:15 p.m. President James Deice will preside. Reservation deadline is Friday. For reservations and membership information, call Judy Deice at 654-7600 or Louise Castellani at 654-6454.


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|Bess ruled out of Dolphins' finale at New England
|Written by Admin
|Friday, 28 December 2012 11:18
It will be the third consecutive game Bess has missed. He finishes the season with 61 catches for 778 yards and one score.
Cornerback Nolan Carroll (knee) and defensive tackle Randy Starks (family reasons) were listed Friday as questionable. Cornerback Sean Smith, who left last week's game against Buffalo with a bruised left knee, was limited in practice for the second day in a row and is listed as probable.
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text: We went for a 1-week drive on the English south coast from Cornwall to Canterbury, staying at various B&Bs on the way. Our first B&B stay, two nights at The Old Fire Station, was by far the most enjoyable. During our two nights, it felt like we were staying with friends and I especially enjoyed our great breakfast talks. This... More


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Rhythm And Blues
Jagged Edge performs in studioComment
In the music world, keeping a band together is no easy feat. One R&B group has been performing together since 1996, making them one of the longest lasting platinum-selling groups!
Bobby Womack, R&B singer-songwriter, dies at 70
Bobby Womack, a colorful and highly influential R&B singer-songwriter who influenced artists from the Rolling Stones to Damon Albarn, has died. He was 70.
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Compositions of matter are provided comprising a pharmaceutically effective amount of taxol or a tumor-active analog thereof solubilized in a pharmaceutically acceptable carrier comprising an oil having a dipole moment of between about 0.5 Debyes and about 2.0 Debyes, and preferably between about 1.6 and about 1.7 Debyes. Oils from marine organisms having an ether lipid as a major component thereof are preferred. Methods of solubilizing taxol or tumor-active taxol analogs in the pharmaceutically acceptable oils of this invention are provided comprising forming a first solution by dissolving taxol in a preliminary solvent such as an anhydrous alcohol, then adding sufficient oil to solubilize said first solution. Taxol-in-oil solutions are used to prepare oil-in-water emulsions for pharmaceutical use in anti-tumor therapy by means known to the art using known surfactants. Self-emulsifying glasses comprising taxol or tumor-active taxol analogs are also provided comprising a water-soluble, nonsurface active matrix compound and taxol-oil solutions. Emulsions are readily formed from such glasses by contacting the glass with an aqueous phase.
1. A composition of matter comprising a pharmaceutically effective amount of taxol or a tumor-active analog thereof, completely solubilized in a squalene or squalane oil.
2. The composition of matter of claim 1 comprising a pharmaceutically effective amount of taxol completely solubilized in said squalene or squalane oil.
3. The composition of matter of claim 2 which contains at least about 0.5 mg/ml taxol.
4. The composition of matter of claim 3 in emulsion form.
5. The emulsion of claim 4 which does not contain a surfactant.
6. A composition of matter consisting essentially of a pharmaceutically effective amount of taxol completely solubilized in a squalene or squalane oil.
7. The composition of matter of claim 6 containing about 10 mg/ml of taxol.
8. A method for solubilizing taxol or a tumor-active taxol analog in a pharmaceutically acceptable carrier which is a squalene or squalane oil comprising the steps of:
(a) solubilizing taxol or said taxol analog in an anhydrous alcohol;
(b) mixing the alcohol solution of (a) with a sufficient amount of said pharmaceutically acceptable carrier to solubilize said alcohol solution therein; and
(c) removing said anhydrous alcohol from said carrier solution formed in step (b) by rotary evaporation thereby resulting in a carrier solution in which said taxol or taxol analog is completely solubilized in said squalene or squalane oil.
This application is a C-I-P of Ser. No. 07/830,058, filed Feb. 3, 1992, which is a C-I-P of Ser. No. 07/531,847, filed Jun. 1, 1990, both now abandoned.
This invention is in the field of pharmaceutical compositions, specifically compositions containing the anti-cancer drug, taxol.
This application is a continuation-in-part of U.S. patent application Ser. No. 07/830,058, filed Feb. 3, 1992, now abandoned, incorporated in its entirety by reference herein, which is a continuation-in-part of U.S. patent application Ser. No. 07/531,847, filed Jun. 1, 1990, also incorporated in its entirety by reference herein. Said Ser. No. 07/531,847 is a continuation of International Patent Application PCT 91/03864, filed May 31, 1991, and Applicant claims benefit of the filing date of that application. PCT 91/03864 is incorporated in its entirety by reference herein. This application also incorporates by reference U.S. patent application Ser. No. 07/954,817, filed Oct. 1, 1992, which is a continuation-in-part of U.S. patent application Ser. No. 07/830,058, now abandoned
Taxol is a poorly water soluble alkaloid isolated from several species of Western Yew. Taxol exhibits antimitotic properties and is presently undergoing phase I clinical trials for the treatment of cancers. Taxol has been shown to be active against leukemia, colon, breast, melanoma, sarcomas, and Lewis lung tumor systems. Tarr et al. (1987) Pharm. Res. 4:162-165; Horwitz (1992) TIPS 13:134-131. In vitro studies indicate that concentrations of taxol (0.1-10.0 μg/ml, stabilize microtubules, thus disrupting normal cell division. Rowinsky et al. (1990) J. Natl. Cancer Inst. 82:1247-1259.
Taxol is a complex diterpene having a taxane ring system with a four-membered oxetane ring and an ester sidechain at position C-13, as follows: ##STR1##
In an attempt to increase taxol's solubility and develop more feasible clinical formulations, investigators have acylated carbons of taxol's taxene ring at the 7-position and 10-position. These efforts have yielded compounds that retain activity. Rowinsky et al. (1990) J. Natl. Cancer Inst. 82:1247-1259.
Because of its poor solubility in water and many oils, taxol has been administered in formulations using cremophors. Cremophors are polyoxyethylated castor oils. The current Sigma taxol formulation most widely used consists of ethanol:cremophor EL:isotonic saline (5:5:90). The drug's solubility in this vehicle does not exceed 0.6 mg/ml and it remains physically stable only for a short time (3 hr). Therefore, large volumes of these formulations, with limited solubility, would have to be infused to obtain a desired total dose of 30 mg. Tarr et al. (1987) Pharm. Res. 4:162-165. The patient is usually required to check into a hospital and endure intravenous infusion for an extended period, such as twenty-four hours. Typically, taxol is administered intravenously in a preparation containing 30 μg/ml over a period of twenty-four hours, followed by a week of rest and another dose. This is repeated two more times.
Further, the BASF cremophor EL (polyoxyethylated castor oil), is extremely toxic and has been shown to produced vasodilation, labored breathing, lethargy, hypotension and death in dogs. Rowinsky et al. (1990) J. Natl. Cancer Inst. 82:1247-1259. Anaphylactoid reactions attributed to the cremophor have also been observed. Green et al. (1987) Cancer Treat. Rep. 71:1179-1184.
Hypersensitivity reactions have been observed using the above formulation; one patient had a fatal reaction. It is unclear whether taxol itself or its cremophor vehicle is principally responsible for the hypersensitivity reactions. Rowinsky et al. (1990) J. Natl. Cancer Inst. 82:1247-1259.
Cosolvents have also been utilized in taxol preparations but require infusion times even longer than the currently-used formulation. Drugs with cosolvent formulations may precipitate if infused too fast.
In an attempt to overcome the taxol formulation problems using the toxic cremophor, and in an attempt to provide a formulation from which the active ingredient would not precipitate out from the aqueous solvent after IV administration, Tarr et al. (1987) Pharm. Res. 4:162-165, attempted to formulate taxol with Intralipid (trademark of RabiVitrum (formerly Cutter Medical) comprising soybean oil, lecithin, egg yolk phospholipids, and glycerol), a commonly used parenteral emulsion; however, the poor solubility of taxol in soybean oil (0.3 mg/ml) made this vehicle unsuitable.
Tarr et al. then made taxol emulsion formulations using triacetin, in which the solubility of taxol is 30 mg/ml, along with emulsifying agents L-alpha-lecithin, pluronic F-86 of BASF company, polysorbate 80 of Sigma Chemical Co., and ethyl oleate. Glyercol was also added to slow creaming. Toxicity of the formulation was observed, including lethargy, ataxia and respiratory depression in animal models, presumably due to the toxicity of the triacetin. The emulsion showed an intravenous LD50 of 1.3 ml/kg in mice. The tricetin emulsion initially gave a 1 μm average diameter droplet and exhibited instability, separating into two phases at six months. Vigorous shaking again formed an emulsion having an average droplet size of 2 micrometers.
As taxol has been determined to be an especially effective anti-cancer agent, formulations which do not contain toxic ingredients and which allow delivery of pharmaceutically relevant dosages in a reasonable period of time, such as orally or by injection, are especially needed. Such formulations have not been previously available.
Methods and compositions for solubilizing pharmaceutically relevant dosages of taxol in pharmaceutically acceptable oils are therefore highly desirable objects of this invention.
The use of oil-in-water emulsions for delivery of taxol and its active analogs are needed to avoid problems of precipitation of I.V. solutions at the time of administration, increase bioavailability of orally administered taxol and prevent gastrointestinal upset. In nonemulsified form, taxol is degraded in the stomach. However, prior efforts to produce pharmaceutically-acceptable emulsions containing the taxol have failed due both to the relative insolubility of taxol in typical pharmaceutically suitable oils and due to the need for the use of toxic surface-active agents.
U.S. application Ser. No. 07/830,058 which is incorporated herein by reference, provides novel methods and compositions for forming pharmaceutical emulsions without using conventional surfactants. The use of these novel emulsification methods and compositions in combination with the novel solutions of taxol and its active analogs provided herein are objects of this invention.
Pharmaceutically acceptable oils useful in forming oil-in-water emulsions are well-known to the art and include vegetable, animal and marine oils. However, the poor solubility of taxol in most oils, such as safflower, olive and soybean oil (about 0.3-0.6 mg/ml), has prevented the use of such oils in previously-known taxol formulations.
Marine oils, especially those that are classified as ether lipids as opposed to triglycerides, are known to the art and include orange roughy, squalane, squalene and shark liver oil.
This invention provides compositions of matter comprising a pharmaceutically effective amount of taxol or a tumor-active analog thereof solubilized in a pharmaceutically acceptable carrier comprising an oil having a dipole moment of between about 0.5 Debyes and about 2.0 Debyes, and preferably between about 1.6 and about 1.7 Debyes. Oils from deep-water marine organisms are preferred.
The compositions of the present invention show a many-fold increase (up to five hundred times) of oral absorption over the prior art formulation using the EL cremophor (Trademark of BASF).
Solutions of taxol or tumor-active taxol analogs in the pharmaceutically acceptable oils of this invention may be prepared by directly dissolving taxol in the oil or by forming a first solution by dissolving taxol in a preliminary solvent such as an anhydrous alcohol followed by mixing with the oil and evaporation of the solvent.
The solutions of taxol or tumor-active analogs of taxol made by the methods of this invention are preferably used to prepare oil-in-water emulsions for pharmaceutical use in anti-tumor therapy. Emulsions are preferred vehicles for taxol for both intravenous and oral administration, and can be prepared by means known to the art using known surfactants from the solutions of taxol in oils of this invention.
Oil-in-water emulsions containing taxol can also be made using self-emulsifying glasses prepared as disclosed in abandoned U.S. Ser. No. 07/830,058 and subsequent related applications. Such glass compositions comprise a water-soluble, nonsurface active matrix compound and an oil containing solubilized taxol from which emulsions can be readily formed by contacting the glass with an aqueous phase.
The oil-in-water emulsions produced from these self-emulsifying glasses do not require art-recognized surfactants or emulsifying agents. The matrix compounds are not surface active agents, surfactants or emulsifying agents. Among others, monosaccharides, disaccharides and nonsugar sweeteners such as cyclamates, saccharines and water soluble polymers including polyvinylpyrrolidones (PVP), cellulose derivatives, dextrans and maltodextrins function as matrix compounds in the formation of such self-emulsifying glasses.
A pharmaceutically effective emulsion containing taxol is produced from the self-emulsifying glass by mixing with sufficient aqueous phase, to form an emulsion. No emulsive mixing or surfactants are necessary.
Such emulsions are administered to patients suffering from cancers against which taxol is known to have a therapeutic effect in appropriate oral or intravenous dosages to effect reduction in the disease.
A composition of matter is provided comprising a pharmaceutically effective amount of taxol or a tumor-active analog thereof solubilized in a pharmaceutically acceptable carrier comprising an oil having a dipole moment of between about 0.5 Debyes and about 2.0 Debyes, and preferably between about 1.6 and about 1.7 Debyes.
A pharmaceutically relevant dosage or pharmaceutically effective amount of taxol for humans is about 30 mg per dose, repeated several times at weekly intervals. At solubilities of taxol in present formulations and because of the toxicity of the cremophor used in the formulation, concentrations of only about 30 μg/ml are presently used to administer taxol, thus requiring a volume of 1,000 ml for a single dose. Concentrations of taxol in oil up to about 10 mg/ml are achievable through the use of this invention, thus allowing delivery of a pharmaceutically relevant dose in a significantly lower amount of the pharmaceutical preparation. The final emulsions of this invention carry from 0.5-5 mg/ml of taxol, thus allowing delivery of the drug in up to one one-hundredth or less of the volume now used without toxic cosolvents or cremophores.
Tumor-active analogs of taxol are known to the art and include analogs having acylated carbons of the taxene ring at the 7-position and 10-position.
Pharmaceutically acceptable oils are known to the art and include vegetable, flower, animal and marine oils. The oil used for solubilizing taxol is preferably a marine oil, and more preferably, a deep-water marine oil. Oils having ether lipid as a major component thereof are preferred. Orange roughy oil, shark liver oil, squalene or squalane oil are preferred.
Dipole moment measurements of various oils are readily available in the literature, (e.g., McClellan, A. L. (1963), "Table of Experimental Dipole Moments," W. H. Freeman (publishers), San Francisco, Calif.; and Smith, J. W. (1955) "Electric Dipole Moments," Buttersworth Scientific Publications, London), and are experimentally determined by the method of oscillometry (Reilley, C. N. (1954), in New Instrumental Methods in Electrochemistry, P. Delahey (ed.), Interscience, New York, N.Y. pp. 319-345) or comparison to drug solubility (Gorman, W. G. and Hol G. D. (1964) Hol. J. Pharm. Sci. 53:1017).
The solutions of taxol or tumor-active analogs of taxol made by the methods of this invention are preferably used to prepare oil-in-water emulsions for pharmaceutical use in antitumor therapy. Emulsions are preferred vehicles for taxol for both intravenous and oral administration, and can be prepared by means known to the art using known surfactants from the solutions of taxol in oils of this invention. Surfactants useful in the preparation of such emulsions include, e.g., Pluronic F-86™ (BASF), polysorbate Tween 80™, those having HLB values between 10-13, and preferably Pluronic F-86.
This invention also includes self-emulsifying glasses prepared by the methods disclosed in abandoned U.S. Ser. No. 07/830,058, filed Feb. 3, 1992, incorporated herein by reference, and related applications. Such glass compositions comprise a water-soluble, nonsurface active matrix compound and an oil containing solubilized taxol or tumor-active taxol analog from which emulsions can be readily formed by contacting the glass with an aqueous phase.
No emulsive mixing or art-recognized surfactants are required to form emulsions from such self-emulsifying glasses. The matrix compounds are not surface active agents, surfactants or emulsifying agents. Among others, monosaccharides, disaccharides and nonsugar sweeteners such as cyclamates, saccharines and water soluble polymers including polyvinylpyrrolidones (PVP), cellulose derivatives, dextran, and maltodextrins function as matrix compounds in the formation of such self-emulsifying glasses. Saccharides including but not limited to sucrose, fructose and trehalose function as matrix compounds in the subject glasses. Preferred nonpolymeric matrix compounds are molecules which taste sweet, more preferred are molecules which are at least about as sweet as sucrose. Saccharides, monosaccharides, disaccharides, sugar alcohols and sugar derivatives, like chlorinated sugars, which are at least about as sweet as sucrose, are useful as matrix compounds. Nonsugar sweeteners useful as matrix compounds include various sweet tasting molecules including but not limited to amino acids, amino acid derivatives, Aspartame (Trademark) and derivatives thereof, and sulfamates including cyclamates, saccharines, acesulfams and derivatives thereof.
Polymeric matrix compounds that are useful in self-emulsifying glasses include among others, PVPs, dextran, maltodextrins and cellulose derivatives. Crosslinked and noncrosslinked PVPs ranging in molecular weight from about 15 to 70 thousand can be processed by the methods described herein to form self-emulsifying glasses. Water-soluble cellulose derivatives including carboxymethyl-cellulose and hydroxyalkycelluloses including hydroxmethyl- and hydroxypropylcelluloses can be processed by the methods described herein to form self-emulsifying glasses. Useful maltodextrins are dextrose copolymers with starch, classified as having dextrose equivalents from about 5 to about 25. Both agglomerated and nonagglomerated forms of maltodextrin function in such self-emulsifying glasses.
Molecules possessing a tripartite glucophore having the three structural features of a proton donor, an electronegative atom and a hydrophobic region are of particular use as matrix compounds in the preparation of self-emulsifying glasses, especially where water is the preferred solvent.
The tripartite glucophore is a structural feature associated with sweetness which consists of a polarizable bond, designated AH or A, an electronegative atom, designated B and a third feature. Initially two structural features: a proton donor or more generally a polarizable bond and an electronegative atom separated in space by about 2.5 to 4.0 Å were described as minimally required for sweet taste (Shallenberger and Acree (1967) Nature 216:480). Examples of AH include O-H groups, N--H groups and C--H groups of cycloalkyl groups or aromatic rings. Examples of B include oxygen atoms, oxime groups, nitro groups, carbonyl groups, and S--O or SO2 groups. The AH, B unit in the cyclamate and saccharin sweeteners are assigned to the NH--SO2 moieties. The third feature, designated X herein, is associated with increasing intensity of sweetness. The X feature is described specifically as a lipophilic region or hydrophobic bonding area (Deutsch and Hansch (1966) Nature 211:75), or more generally as a region capable of dispersive bonding or a region susceptible to electrophilic attack (Kier (1972) J. Pharmaceutical Sci. 61:1394-1397). Examples of the X feature include alkyl and alkenyl groups, cycloalkyl and cycloalkenyl groups, aromatic rings, and the C-2 substituent in aminonitrobenzenes. All three features are described as involved in binding of a sweet molecule to the taste receptor.
The features of the tripartite glucophore form a triangle with the AH-B distance ranging from about 2.5-4.0 Å, the AH-X distance ranging from about 3.1 to 5.2 Å and the B-X distance ranging from about 5.2 to 7.4 Å. The triangular tripartite glucophore structure is more narrowly depicted with an AH-B distance of about 2.6 Å, a B-X distance of about 5.5 Å and an X-AH distance of about 3.5 Å. Intensity of sweetness is associated with better fit or improved binding in the receptor. Sweet-tasting compounds which possess a tripartite glucophore, particularly in which the X feature is a region capable of hydrophobic bonding, are useful in the preparation of self-emulsifying glasses via the water solvent method as described herein. Those compounds possessing the tripartite glucophore which are sweeter than sucrose are preferred matrix compounds for use in the compositions and methods of the present invention.
The tripartite glucophore structure is found not only in sweet molecules, but also as a feature of the monomers which make up the polymeric matrix materials useful in this invention, such as PVP.
The weight ratio of matrix compound to oil phase in a self-emulsifying glass is more preferably between about 2:1 and 20:1 and most preferably between about 2:1 and 10:1.
The compositions of the present invention are also termed "inclusion compounds" herein. Matrix materials used herein may also be described in terms of their ability to form inclusion compounds or aggregates incorporating the oleaginous materials of this invention. Such matrix materials are capable of forming chains of indefinite length, either due to the fact that they are polymeric materials or by intermolecular hydrogen bonds in the presence of oil, such chains having surfaces that are relatively hydrophobic and surfaces that are relatively hydrophilic. The oleaginous material is enclosed within the cavities or interstices formed by lipophilic regions of the chains (Harata, K. and Vedaira, K. (1975) Bull. Chem. Soc. Jap. 48:375). When the solvent used to form the self-emulsifying glass is removed the matrix material forms a structure which "includes" the oleaginous material within it in discretely separated aggregates or small portions. The use of the word "compound" does not imply a definite stoichiometry. The molar ratio of oil to matrix may vary, as may the size of the matrix chains.
In general, the various matrix compounds can be admixed to form glasses of the present invention. Employing a mixture of matrix components can, for example, lead to self-emulsifying glasses with higher glass transition temperatures. The higher the glass transition temperature, the more kinetically stable the glass.
Glasses with higher glass transition temperatures will be generally more stable to storage and have longer shelf-lives. It is generally preferable that glass transition temperatures be about 20� C. or more above room temperature. Mixtures of nonpolymeric matrix compounds, such as sucrose, with polymeric matrix compounds, such as maltodextrin, result in glasses with higher transition temperatures compared to glasses formed with the nonpolymeric matrix compound alone. In particular, the use of a mixture of sucrose and maltodextrin as the matrix compound results in glasses having higher glass transition temperatures than sucrose-based glasses.
It is preferred in the subject self-emulsifying glasses that the weight ratio of the matrix compound to the oil phase is at least about 2:1.
Solutions of taxol or tumor-active taxol analogs in the pharmaceutically acceptable oils of this invention may be prepared by dissolving taxol crystals directly in the oil, preferably with the application of heat. More rapid dissolution is obtained by first dissolving the taxol in a more volatile, less viscous preliminary solvent such as anhydrous alcohol, e.g., ethanol or methanol. The primary solution is then mixed with an oil of this invention having a dipole moment of between about 0.5 and about 2.0 Debyes to form a second solution. This second solution may at this point be treated to remove the preliminary solvent, preferably by heating. Alternatively, the solvent may be removed later in the process as described below.
Solutions comprising taxol or a tumor-active taxol analog in a preferred oil can be emulsified by means known to the art to form pharmaceutical 10% w/v oil compositions having concentrations of the tumor-active ingredient of at least about 0.5 mg/ml up to about 5 mg/ml. Useful emulsions of this invention have concentrations of the tumor-active ingredient of about 3 mg/ml.
To avoid the use of surfactants which may be toxic or cause undesirable side-effects, it is preferred that such emulsions be produced using the self-emulsifying glasses described above.
Self-emulsifying glasses containing taxol and tumor-active taxol analogs are preferably prepared by combining the tumor-active ingredient and oil solution described above, with or without the presence of the preliminary solvent, with a nonsurface active matrix material, as defined above, and a sufficient amount of a solvent for the matrix material, such that substantially all of the matrix compound is dissolved to form a combination such that the combination is not a stable emulsion, followed by removing the solvent for the matrix compound, along with any preliminary solvent that may be present, from the combination such that a glass results.
The solvent for the matrix material employed can include but is not limited to water, aqueous solvents, aqueous alcohols, ethanol, methanol, and organic solvents in which the matrix compound is soluble, including among others, chloroform. Water and aqueous solvents including aqueous alcohols are preferred.
The matrix material and oil solution containing taxol or tumor-active taxol analog are preferably combined such that the weight ratio of the matrix compound to the oil solution is at least about 2:1. Solvent removal is preferably done by evaporation by application of a vacuum accompanied by nonvigorous mixing, i.e., nonemulsive mixing, most preferably by rotoevaporation. Solvent is removed until a dry-appearing solid, solid foam or film is produced. Rotoevaporation results in bubbling of the combination and the solid resulting from removal of solvent has the appearance of a solid foam. Substantially all the solvent is removed, leaving trace amounts of solvent, i.e., around 0.2 to about 0.5 percent.
The solid left after removal of substantially all the solvent is a glass. Glasses formed using nonpolymeric matrix compounds or mixtures of polymeric and nonpolymeric matrix compounds often retain some level of short or medium range molecular order, designated microcrystallinity herein, as measured by differential scanning calorimetry (DSC). Glasses which are fully amorphous, as measured by X-ray diffraction and DSC can be prepared, but fully amorphous glasses may be very hygroscopic and the absorption of significant amounts of water into glasses is detrimental to their functionality and shelf-life. Thus, glasses retaining some level of microcrystallinity, from about 10% to 60% microcrystallinity as measured by DSC, are preferred. The subject glasses do not retain more than about 10% long range molecular order as measured by X-ray diffraction.
In the case in which a nonpolymer is employed as or in the matrix compound, it is preferred that the solvent be removed at a rate that is fast enough to prevent the formation of significant, i.e., greater than about 10%, long range molecular order via crystallization of the nonpolymer component of the matrix compound. This can generally be achieved if the rate of solvent removal is faster than the rate of crystallization of any matrix component from the solvent solution.
The process steps can in many cases be performed at about room temperature. It is preferred that the process steps are performed at the lowest temperatures possible which allow generation of a dry-appearing solid, still keeping the taxol or tumor-active taxol analog in solution. The process steps should be performed to avoid melting or decomposition of the matrix compound, i.e., the process should be performed at temperatures less than about the melting point or decomposition point of the matrix compound, generally about 140� C. or less. Taxol is stable for at least about two hours at 130� C. Under vacuum taxol tends to precipitate from the oil solution at bath temperatures less than 50� to 60� C. Thus preferred temperatures for performing the process steps are about 60� C. to about 130� C.
If preliminary solvent is present, and if it is desired to remove it prior to adding matrix materials, preferred temperatures for removing the preliminary solvent from the taxol and oil solution are between about 60� C. and about 70� C., preferably about 60� C. This step is preferably done by heating under a nitrogen blanket for a sufficient period to remove substantially all the solvent, typically about 20 minutes.
The matrix material, preferably sucrose, is mixed with the taxol and oil solution, which may also contain preliminary solvent, at a preferred ratio of between about 2:1 and about 20:1::matrix:oil solution. The solvent for this composition, preferably water, is then added, preferably using the smallest amount of solvent which will dissolve the composition, i.e., about 2:1::solvent:matrix/oil phase. The solvent may be heated to aid in dissolution, preferably to about 80� C., for a sufficient period of time to dissolve the composition, i.e. about five minutes.
Solvent is then removed from the solubilized composition, preferably by rotoevaporation, under vacuum, preferably starting at about 500 mbar and increasing to maintain bubbling. The vapor temperature should be kept at about 30� C. or higher. When the vapor temperature no longer increases, usually after about half an hour, maximum vacuum is applied. The self-emulsifying glass is collected from the film or foam formed in the reaction vessel as a dry-appearing solid. The glass should be stored at room temperature at less than about 30% relative humidity.
A pharmaceutically effective emulsion containing taxol is produced from the self-emulsifying glass by mixing with sufficient aqueous phase, preferably an isotonic solution such as Normal Saline or 5% dextrose (D5W), to form an emulsion. No emulsive mixing or surfactants are necessary. The aqueous phase is added to the glass preferably at a ratio of between about 1 ml:1 g, and about 5 ml:1 g::aqueous phase:glass, to form a composition having a pharmaceutically-effective concentration of the tumor-active ingredient.
The emulsion so formed, after storage for several hours without agitation, has a particle size between about 5 μm and about 1 μm and remains stable at room temperature for periods of three weeks or more. Droplet size decreases over time. Droplet size of the emulsion as initially formed may be larger, e.g., between about 10 μm and about 2 μm.
For therapeutic use, emulsions containing between about 0.5 and about 5 mg/ml taxol or tumor-active taxol analog are prepared by the foregoing methods and administered orally or intravenously.
Taxol (Sigma T-7402), 4.0 mg, was dissolved in anhydrous methanol. The taxol solution was added to 0.400 ml squalane oil (Sigma S-4510, lot 88F3528). The methanol was then removed with heating and nitrogen blanket at about 60� C. for 10 minutes. The taxol was completely solubilized in the squalane oil.
The taxol-in-oil solution of Example 1 was added to 1.62 g of sucrose in a 100 ml vacuum flask. Sufficient water to just dissolve the sucrose was added to the flask and the mixture was heated to 80� C. in a rotary evaporator for approximately five minutes. Vacuum was applied to the flask at 500 mbar, and continually increased to maintain bubbling. Vapor temperature was maintained no lower than 30� C. When the vapor temperature no longer increased, after about 30 minutes, maximum vacuum was applied and the flask lifted out of the water bath. The self-emulsifying glass product in the form of a foam was collected from the flask. The glass had a moisture content of less than or equal to 0.1% to less than or equal to 0.29%.
The self-emulsifying glass of Example 2 was added to 0.8 ml normal saline and gently swirled by hand to produce an oil-in-water emulsion comprising taxol in the oil phase. Droplet size was measured at about 2-10 μm.
The emulsion Example 3 was tested for therapeutic activity as follows:
Twelve mice weighing 14 to 25 grams, strain A/J (lung tumor model as described in Malkinson, A. M. (1920 Cancer Res. (suppl.) 52:2670s-2676s), in which urethane-induced lung tumors, at an average of 30 per mouse after 14 weeks of treatment, are treated with the emulsion of Example 3 for a dosage of 5 mg/kg taxol. The emulsion is administered by bolus i.v. Treatment cycle is repeated four times. Controls using identical procedures and an equivalent oil/sucrose glass emulsion free of taxol are performed. At the end of the study tumor number in the rats treated with the formulation of this invention decreases significantly compared to controls.
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*+-JP Sotille: The American diet is now a mine-field of sickness, empty calories and chemical additives. And the number-crunching folks at Coca-Cola think this mine-field may blow-up in their faces.
Progressive Media Advocates
By JP Sottile
-+*Treva Brandon Scharf: Can't afford a gym membership? Get bored easily by exercise? Don't want to run into your ex at Equinox? No problem! There's always the great outdoors – otherwise known as your local park.
-+*Walter Moss: There is little chance that any Republican nominee will put dealing with climate change at the center of his/her agenda, but we progressives should insure that at least the Democratic nominee does.
-+*Annette Bernhardt: The inequality debate often focuses on globalization and new technology, but we know that the decline of unions and the falling real value of the minimum wage have also played critical roles.


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By: Smokn
part 8 DreamHack video from FarCry2...sorry bout quality ;)
Views: 1,793 | Posted: 05/25/2011
By: Smokn
Part 4... Far Cry 2 Game play. Newest footage FC2. Oh yaaa, baby...it's awesome
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By: Smokn
classic fc1 video showing how cool this old editor is compared to forging !......Do you agree?
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By: SpappyProduction
Choose Your Way
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By: Styzzo
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By: TurdRocket87
A video review I created for the Xbox game Far Cry: Instincts. This video was edited with footage provided by IGN.com, GameSpot, and File Front.
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By: gogogadgetboots
The Far Cry movie based on the original PC Version of the game.
Views: 1,022 | Posted: 05/02/2011
By: Smokn
Excellent map editor game play from Far Cry...guy does tricks on boat in air after launching off jump !! Extremely cool use of map editor custom multi-player. Forge can not touch this!! (c blog ;'), Smokn
Views: 3,155 | Posted: 12/10/2010
By: tormentor83
First approach to the MP features
Views: 748 | Posted: 09/16/2010
By: Enleydo
This is the official Trailer to Far Cry the Movie by Uwe Boll. I really enjoyed the game and I still do, but this trailer makes me'Cry'. I still din't understand why Crytek/Ubisoft sold the Rights to Uwe Boll. PS: es, the song when the Trailer starts was/is from Nolan's 'Batman Begins'.
Views: 1,390 | Posted: 08/25/2010
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The fourth chapter of a new story within the "Story of Ice and Fire" universe made by Telltale Games.
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An endless runner themed in the Lara Croft: Tomb Raider universe.
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The fourth chapter of a new story within the "Story of Ice and Fire" universe made by Telltale Games.
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The fourth chapter of a new story within the "Story of Ice and Fire" universe made by Telltale Games.
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Live the life of one of Earth's most destructive forces in this first-person cat simulator.
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The finale of Rocksteady's Batman Arkham series! Scarecrow rallies Batman's greatest villains to defeat the Dark...
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The following Official Record for JAMES MCCARREN is being redistributed by LCN and is protected by constitutional, publishing, and other legal rights. This Official Record was collected on 3/10/2014. The person named in this listings has only been arrested on suspicion of the crime indicated and are presumed innocent.
JAMES MCCARREN of Ripon, CA was last arrested on 7/12/2014
Arrest for JAMES MCCARREN
|Arrest Name:
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|273.5 Inflict Corporal Injury On Spouse/Cohabitant
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Polling of more than 30,000 people in countries ranging from the UK to Brazil revealed that seven out 10 (71 per cent) believed the Arctic Ocean should be free from oil drilling.
And almost two-thirds (64 per cent) thought oil drilling, oil transportation and industrial-scale fishing should be banned in international waters around the North Pole.
Across the world 74 per cent of people backed an Arctic sanctuary.
Meanwhile in the UK support was even stronger at 78 per cent.
Backing for a formally protected area for animals and marine life was highest in Argentina, Italy, India and South Africa, but it was also high in Arctic states such as Canada and the US, with almost four-fifths (78 per cent and 79 per cent respectively) supporting a sanctuary.
Two-thirds of people quizzed in the UK thought the Arctic should be free from oil exploration.
A similar number thought drilling, oil transportation and large-scale fishing should be banned in international waters round the North Pole.
The poll for Greenpeace, which last year saw 30 people on its ship the Arctic Sunrise detained by Russian security forces over a protest against oil drilling in the Russian Arctic's Pechora Sea, comes as it ramps up calls for a sanctuary in the High Arctic.
Climbers and mountaineers are scaling mountain peaks and buildings throughout the day to unfurl banners calling on governments to "Save the Arctic".
More than 900 influential people including Archbishop Desmond Tutu, Emma Thompson, Sir Richard Branson and Sir Paul McCartney have signed Greenpeace's Arctic Declaration in the past two months.
The declaration which is calling for the creation of a protected area in the region to preserve its wildlife and prevent the carrying out potentially damaging activities such as oil drilling, will be presented to the embassies of Arctic states around the world.


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Diocese of Lansing Theology of the Body Retreat Day« Back to Events
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Spend a day reflecting on the life, calling, and destiny of the human person. Join us on the eve of Divine Mercy Sunday and the canonization of Blessed John Paul II.
To register, visit: www.dioceseoflansing.org/vocations
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In IOS6 map data was replaced from Google to Apple's own map data.
In the past, when MapKit was used you had to accept Google Maps licensing and terms of use (https://developers.google.com/maps/iphone/terms). What is the situation with the new MapKit and its new map data? E.g. GoogleMaps was not enabled to use in commercial apps by free, to use it you had to buy some premium packages. Etc.


text: Red Skies of Montana is a 1952 adventure drama in which smoke jumper Cliff Mason, Richard Widmark, attempts a save his crew while being over-run by a forest fire, not only to save his men, but to redeem himself after his last fire when he was the only survivor. Richard Widmark plays a firefighter for the US Forestry Service, a brave man who nevertheless does not believe in taking foolish risks. Widmark is branded a coward by a rookie fireman (Jeffrey Hunter) who holds Widmark responsible for the forest-fire death of the rookie's father. All passions are swept aside when a particularly brutal fire strands Widmark and his men in the middle of unprotected forest. Widmark then realizes that he must attempt to lead the others to well-being. Red Skies of Montana represents the film debut (in an unbilled role) of future TV and film star Richard Crenna. ~ Hal Erickson, All Movie Guide Richard Widmark ... Cliff Mason Constance Smith ... Peg Mason Jeffrey Hunter ... Ed Miller Richard Boone ... Richard 'Dick' Dryer Warren Stevens ... Steve Burgess James Griffith ... Boise Peterson Joe Sawyer ... Pop Miller Code: http://www.imdb.com/title/tt0045074/ Code: http://rapidshare.com/files/250192623/Red_Skies.part01.rar http://rapidshare.com/files/250198266/Red_Skies.part02.rar http://rapidshare.com/files/250203865/Red_Skies.part03.rar http://rapidshare.com/files/250209985/Red_Skies.part04.rar http://rapidshare.com/files/250216154/Red_Skies.part05.rar http://rapidshare.com/files/250221761/Red_Skies.part06.rar http://rapidshare.com/files/250227942/Red_Skies.part07.rar http://rapidshare.com/files/250234028/Red_Skies.part08.rar http://rapidshare.com/files/250236151/Red_Skies.part09.rar No Password


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Chapter 18.
Had he just asked me out on a date? That man had a serious way of getting inside my head. It was like he knew exactly what I was thinking.
"What's up with you?" Annie asked wiping her hands in a tea towel.
"I don't even know." I sighed and rubbed my temples.
"Sit and tell me." She ordered and ushered me into the kitchen and up onto one of the stools.
"Oh Annie, there's nothing to tell." I muttered, chewing absently on my lip.
"Violet, you have been there for me ever since I was young, now I'll be here for you. Please tell me." She urged.
I sighed. I could barely even think about it to myself let alone say it out loud to Annie. "It's nothing Ann, I'll be fine."
She sat back and stared at me, then threw her hands in the air, frustrated. "Fine, whatever."
"Ann, it's not that I've nothing to say, it's that I can't physically say it!" I yelled in frustration.
"Why not? What could be so horrible that you can't tell me? Is it because I'm younger then you? Because that doesn't matter any more!" She huffed angrily.
"Well I don't know how to tell you! Fuck sake Ann, I don't even know how to say it to myself!" She was making me angry. She had never been happy with John and I as a couple and now she was trying to get me to confess my marriage was far from perfect.
"Say it Violet! Christ, it's not like he's having an affair!" She screamed.
There it was. What I couldn't even admit to myself was out there in the open. It made me ashamed to admit it.
"Ohmigod, that's the reason isn't it?" She gasped. She didn't seem to have been expecting that.
I struggled in a deep breath. "I can't be sure, but I've suspected it for about six months now, ever since his little bitch of an assistant, Martyna started working for him. He's been staying an awful lot later at an art college then he should."
She looked at me, her eyes unseeing for a moment. "What does she look like?"
"Martyna?" I asked hissing out the name. "She's short with dirty blonde hair slime green eyes, she's polish, with a ugly crooked nose and a horrible thin mouth."
She raised an eyebrow. "That's an accurate description yeah? Totally unbiased?"
I shrugged and started playing with the grains of sugar that had landed on the counter.
"Perhaps you're having an over reaction? John doesn't exactly seem like the type to cheat."
"They never do though." I muttered bitterly. "That's the point... You think you've met the most perfect guy in the world then some back stabbing bitch shows up! She fuckin' wiggles her Nicki Minaj arse and steals him from me!"
"Look honey, why don't you go lie down and I'll bring you some tea to settle your nerves, yeah?" She gave me a weak smile and hopped up off the stool.
I nodded and stood up to leave. I suddenly felt very weary and like I'd aged ten years.
When I heard stools scrapping against the kitchen tiles I ducked back into the living room and jumped onto the sofa. My mind was completely blown. Sixteen years ago she left me standing at the alter because she thought John loved her more. Now here we are and now who would've been the most faithful?
My mission for the night was glaringly obvious, I had to win Violet back by showing her what a stand up guy I'd become.
"What're you grinning about?" Mum asked coming in with a bucket filled with coal.
"Nothing. Just glad to be back home." Well it wasn't exactly a lie, there were things I had missed. I had missed the sweet flowery scent of my mum's perfume. I missed the annoying way Annie invaded everyone's privacy even though she was now twenty four! I missed the kitchen smells. The smell of baking and cinammon Then the smell of fairy washing up liquid if you got near the sink. I missed the smell and look of my bedroom. The thing that I had really missed though was Violet. It turns out that I'd missed absolutely everything about her. I missed the way her laugh sounded. To most people her laugh was unattractive because she'd developed a habit of snorting when she laughed, but sixteen years later and I was still smitten. I loved the fire in her eyes when I made her angry. I loved the way she had an air of authority and commanded a rooms attention without even realising it. What could I say? I loved everything about her. She was different and yet same in some way.
"Ah that's nice love," She smiled and pushed a loose strand of greying from her face. "Next time don't leave it so long between visits."
I realized that I'd not only missed alot of familiar things, I'd also missed the people. They'd all gotten older and especially my mum. Her once golden blonde hair was now going whitish grey and her skin was developing wrinkles. She was still unbelievably strong willed though.
"What?" She gave me a funny look as she wiped the soot on her old apron. "Why're you looking at me funny?"
I shook my head and heat flooded into my cheeks. "I just realized how much I missed having you around."
Her expression softened and she came over to me, wrapping her arms around me. "I've missed you too. I told you not to leave it so long."
I hadn't cried once in sixteen years and now sudden hot rush of tears streaming down my face. "I love you mum," I said shakily.
"I love you too Jack. I have since the moment you were born and no matter what happens your always my son and I'll always love you." She sounded like she was holding back tears herself.
"Thanks mum," I whispered.
She pulled back and wiped her tears. "Now go on with yourself. There must be something for ye young kids to be up to."
She was right, there was. I had to get ready for my date. I had to recreate and rebuild my life.
I went up into my bedroom and headed straight for my laptop. I know that sounded like something every teenager does but I had a purpose, I needed to speak to Ethan. The only problem is when I logged into facebook and searched him he was none existence I was going to have to call him. I waited as I pressed 'Call Ethan' in suspense. He hadn't taken the news that we were leaving very well.
"Hello?" He asked passively after the fifth or sixth ring.
"Hey," I barely breathed. Even the sound of his voice was enough to send shivers up my spine.
"What's up?" His voice was emotionless, robotic even.
"Nothing... I was just calling to see how you were." I gulped. Had he completely gotten over me?
"I'm fine... Look Bella I gotta go mom's having a bit of a shit attack and I kinda need to deal with that." He sighed.
"Oh... Yeah... Sure... Bye." My voice was flat.
"Awh Geez Bell! Don't be like that!" He sounded frustrated.
"Like what?" I was confused and angry with him.
"Like a bitch! Like it's my fault!" He snapped.
"I'm acting like a bitch?" I hissed.
"No... Yes... Look I didn't mean that. I'm just stressed out okay?" He sounded worn out.
"Okay yeah." Why bother fighting with him?
"So I'll call you yeah?" He offered in compensation.
"Yeah, fine." With that I ended the call.
Sometimes I really didn't understand that boy. He went from hot to cold to back again. He was infuriating. Did boys take classes in how to be that annoying? I threw my phone at the wall then flung my arms over my eyes.
"What's up with you?" Mom asked from the doorway. She looked as if she were on the verge of tears herself so I had not desire to burden her with my weak ass boy problems.
"Nothing," I grumbled, rubbing at my tears.
"Well you don't look like there's nothing wrong. You always throw your phone at walls when nothings wrong?" She raised and eyebrow. "Yeah thought not. So what's the word humming bird?" She moved over to my bed and pushed the hair from my eyes.
"Ethan is being an idiot." I mumbled.
She smirked slightly but seemed sympathetic. "All boys are idiots Sweetheart. What'd he do?"
"He promised me that we could stay close, so I rang him to let him know everything was okay down here, but when he was speaking he was so robotic and emotionless. Then he said something about his mom freaking out, like he wanted to end the call then he started freaking out and told me he'd call me." I started knotting and un-knotting my fingers.
"You really like this boy don't you?" She sighed seeming troubled by it.
"Why?" I searched her closely trying to understand why this made her sad.
"Nothing honey. I guess I'd always hoped you'd get together with Matt." She sighed and ran her fingers threw her hair.
"Why him?" I wrinkled my nose. Matt had been well and truly friend zoned. More like a brother then anything.
"Well he's a mother's dream for her daughter." She smiled taking my hands in hers. "He respects your parents. He's good to you. He's a gentleman. He's perfect."
On paper he was perfect and I loved him but wasn't there supposed to be a spark? "Mom there's no_"
"No spark." She cut me off. "I remember a time when there was no spark so I left... Now the spark I left for is running dry."
I was going to question her further but she patted my leg as if to tell me not to say any more on the subject.
"I hear Angel and Rach downstairs. I better go. I'm going out tonight. but don't worry princess. Ethan will call. He's just confused, like we all are." She smiled and left the room. Leaving me wondering over her cryptic words.
Sorry for the delay with my update but thanks for sticking with me! So please read and review! :D


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We are the original, first, and only cannabis industry full-staffing company that focuses on meeting *all* staffing needs. Here at Hemp Temps, we combine years of experience and knowledge into a comprehensive understanding of the ins and outs of the MJ industry. We get it, really. We stay on top of this ever-changing industry, because we are deeply involved and committed. We are a Colorado company, based in Denver. We match dispensaries and grow facilities with top notch Hemp Temps to assist with their growing, trimming, bud-tending, and general industry needs.
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Minister of State for Environment and Forests Jairam Ramesh had told Parliament that unsupported actions would not be open for international monitoring, reporting and verification but the progress would be tabled in Parliament
India has "substantially" preserved its development space under the Copenhagen Accord at the just-concluded United Nations climate summit, but operationalising the agreement would be "extremely difficult and contentious," India's negotiator for climate change Prodipto Ghosh said here on Monday.
The clause on international consultation and analysis of unsupported mitigation actions by the countries — for which the guidelines are yet to be finalised — would be the most difficult task, Mr. Ghosh, a former Union Environment and Forests Secretary said.
Mr. Ghosh told The Hindu that the accord was a process that would continue through the next year and culminate in Mexico City at the 16th session of the Conference of the Parties of the United Nations Framework Convention on Climate Change. "We have substantially managed to preserve our development space. But before the accord is operationalised, there will be some hard negotiations on several aspects agreed upon by the countries."
The most difficult and contentious task will be the finalisation of guidelines for the international consultation and analysis of the mitigation actions, which will now be drafted while "respecting national sovereignty," Mr. Ghosh pointed out.
Since developing countries, including India, had refused to accept international monitoring, reporting and verification of unsupported mitigation actions -- though it was willing to be "flexible" -- the accord states that actions by developing countries that were not supported through international finance and technology would also be open to international "consultation and analysis."
Minister of State for Environment and Forests Jairam Ramesh had told Parliament that unsupported actions would not be open for international monitoring, reporting and verification but the progress would be tabled in Parliament and information on such projects provided through a national communication mechanism.
Another negotiator, Rajni Ranjan Rashmi, said India's concerns on non-binding emission cuts were met at Copenhagen though the climate deal did open a window for a new legal treaty that may kill the Kyoto Protocol based on the principle of equity.
Speaking to a news agency here, Mr. Rashmi, Joint Director in the Ministry of Environment and Forests, rejected allegations that India succumbed to the U.S. pressure at the meet. "Equity has been ensured by limiting temperature level to 2 degree Celsius, which has been agreed upon by all the nations, both developing and the developed," he said.
The official, while admitting that it was not a win-win situation for India, said there were positives and negatives in the deal. "No binding commitments have been imposed upon the developing nations."
On the downside, the treaty had opened windows for a new legal treaty that may result in the burial of the 1997 Kyoto Protocol, Mr. Rashmi said of the limited agreement reached. Asked whether the U.S. could challenge emerging economies such as India and China on climate steps, he said the deal was not a legal document and Washington, or for that matter the developed nations, cannot scrutinise domestic mitigation and adaptation steps.
Keywords: climate change, Copenhagen Summit, Environment Minister, Jairam Ramesh, parliament, U.S., India, global warming, Copenhagen Accord


text: JoaoSousa February 10, 2013 5:57 PM F1 » Karthikeyan in Force India link He couldn't even make it into the podium when there were only 6 cars on track! Remember the US GP in 2005? He got shown up by Monteiro - who's not that good anyway. This guy should be playing cricket. NOT taking away F1 drives. Reply Report abuse 5 agree 5 disagree


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MoistAir 6-Gallon Cool Mist Tower Humidifiers with Digital Humidistat
MoistAir 6-Gallon Cool Mist Tower Humidifiers
Click to enlarge image
MoistAir 6-Gallon Cool Mist Tower Humidifiers
Availability: This unit is out of stock for the season. We recommend the MoistAir Slim Tower 6-Gallon Cool Mist Humidifier as an alternative.Shipping Costs*
Item #: ES-HU MA0600
Why Green
- Improves indoor air quality
- Requires little energy
- Protects wood, furniture and other household items from dry air
Expert Rating:
Our MoistAir Cool Mist Tower Humidifiers relieve dry skin, sore throats, sinuses and other symptoms of unhealthy dry air by dispersing up to 6 gallons of comfortable cool mist into the air. The humidifiers also consume little energy and feature a sleek, modern design with unique top airflow to easily fit in tight spaces. The evaporative filter wick humidification helps reduce bacteria and mineral build-up and delivers only clean and natural moisture into the air. Also, the built-in digital humidistat does all the work for you and maintains your desired humidity level with accuracy. This means no more getting up in the middle of the night to adjust the humidity output! Other beneficial features include dry-out mode to reduce bacteria growth on filter, auto shut off, easy to refill bottle tank and control locks to avoid unwanted tampering with the humidifier settings. Covers a bedroom, office or living room up to 1,300 square feet.
- Cool mist humidifier for areas up to 1,300 square feet
- Tower design with top airflow to help fit in tight areas
- Disperses up to 6 gallons of water per 24 hour period
- Water capacity: 2.5 gallons (1.25 gallon water bottle with 1.25 gallon reservoir)
- Built-in digital humidistat: automatically turns on and off to maintain a desired humidity level. Settings set from 25% - 65% in 5% increments. The fan will turn on if the room reading falls 3% below the set point and will continue to run the humidifier until a reading of 1% above the set point is achieved
- Room humidity readings of 20% to 95%
- 3 Fan speeds: low, medium and high
- Auto fan speed: automatically adjusts fan speed depending on room humidity level. Good for energy savings
- Removable water tank – 1.25 gallons capacity
- Water refill light
- Equipped with evaporative filter wick which retains minerals and delivers clean, moist air. Wicks are easy to clean and replace
- Check filter indicator: appears after 720 hours of operation
- Dry-out mode: when tank and base is empty the unit will automatically switch to dry out mode and continue to run on ultra quiet speed for a 2 hour period. This reduces bacteria and mildew growth
- Control lock out to avoid unwanted tampering with the humidifier settings
- Auto shut-off when empty
- Includes 4 easy-roll casters
How it Works
The MoistAir 6-Gallon Tower humidifier uses the principle of evaporation of water in the air. Once the filter wick becomes saturated, air is drawn in, passes through the filter and moisture is absorbed into the air. All evaporation occurs in the humidifier so any residue remains in the filter. This natural process of evaporation virtually eliminates white dust.
Technical Specifications
|Type of mist
|Cool Mist
|Humidifier fan speeds
|3 - Low, medium, high
|Auto shut-off
|Water capacity
|2.5 gallons
|Power supply of humidifiers (Volt, Hertz, Watts)
|120AC, 60Hz, 1.2 Amps, 80 Watts
|Refill Light
|Room area coverage
|1300 sq. ft.
|11.5"W x 15.5"D x 25"H
|Humidification performance
|Up to 6 gallons/24 hours (based on ambient room conditions of 70° F and 30% relative humidity in a room of average insulation)
|Adjustable humidity control
|Yes - digital controls
|10.65 lbs
The unit's simple design will help improve air quality and alleviate symptoms from dry air in a room with a comfortable cool mist. The cool mist will also protect furniture, computers, electronics and other household items from becoming too dry and ultimately prolonging use. The evaporative wick humidification method makes this unit very energy efficient as it only requires less than 80 watts on its highest speed. Overall, the MoistAir 6-Gallon tower humidifier is a convenient, simple to operate unit that gets the job done quickly and effectively.
Make Selections
MoistAir 6-Gallon Cool Mist Tower Humidifiers
Set of 2 Replacement Filters for MoistAir 8-Gallon and 6-Gallon Tower Humidifier Models Only
P3 International P0270 Mold Alert Digital Thermometer/Hygrometer


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LeCroy to Showcase PCI Express® 3.0 Test Suite at PCI-SIG® Developers Conference
SANTA CLARA, Calif., June 21, 2011 /PRNewswire/ — LeCroy Corporation will showcase the most comprehensive and only protocol-aware suite of test and debug solutions for the PCI Express® 3.0 (PCIe® 3.0) specification at the PCI-SIG® Developers Conference in Santa Clara, CA, June 22-23. LeCroy, a platinum sponsor of the conference, will demonstrate an integrated suite of test and debug solutions including physical layer transmitter and receiver test options, TDR/S-parameter measurement devices, and an industry-acclaimed protocol analyzer platform. This advanced test suite addresses the requirements for serial data testing unique to the PCI Express 3.0 specification, which place new demands on traditional physical layer test tools. Not only does the specification mandate that the receiver tester be protocol aware, but certain other characteristics of the PCI Express 3.0 specification, such as dynamic equalization, essentially require combined physical/protocol layer test capabilities for validation and debug. LeCroy is able to provide these capabilities with the most extensive set of physical layer, protocol layer, and network analysis tools for complete PCI Express 3.0 transmitter, receiver, and channel testing available today.
(Photo: http://photos.prnewswire.com/prnh/20110621/NE22744 )
"LeCroy has been and continues to be committed to providing complete, end-to-end solutions for established and emerging serial data standards. Our latest offerings clearly establish LeCroy as the leader with the only complete end-to-end solution for PCI Express 3.0. Our continued investment in this area will ensure our customers that they will always have the most up to date and best-in-class tools for serial data standard debug and compliance measurements," says David C. Graef, Chief Technology Officer of LeCroy.
The PCI Express 3.0 Test Suite addresses transmitter test with the SDA 820Zi-A oscilloscope; receiver test with the PeRT(3) Phoenix protocol-aware receiver and transmitter tolerance tester; S-Parameter and TDR tests with the SPARQ signal integrity network analyzer; and protocol tests with a wide range of protocol analyzers and exercisers that support lane widths from single lane to x16 and data rates of 2.5 GT/s to 8 GT/s, and include the industry's largest assortment of probes and interposers. These instruments are a testament to the ability of LeCroy's product development teams to move beyond many critical hardware and software limitations that challenge today's high-speed design engineers, as well as their long-standing engagement with industry partners and signal integrity groups such as PCI-SIG®, which is the industry organization chartered to develop and manage the PCI standard.
"We're pleased to have LeCroy as a Platinum Sponsor again for our Developers Conference this year," said Al Yanes, chairman and president, PCI-SIG. "LeCroy has been active in PCI-SIG since the earliest days through its involvement in PCI-SIG's Electrical Working Group, which developed the PCIe 3.0 base spec; the Card Electromechanical group and the Serial Enabling Group."
LeCroy PCI Express 3.0 Test Suite Advantages
PCI Express 3.0 transmitter signal integrity and transmitter preset test require a data rate of 8 Gb/s which in turn requires 20 GHz of bandwidth for 5th harmonic captures. The unmatched signal fidelity of the 4-channel, 20 GHz SDA 820Zi-A oscilloscope make it the ideal instrument for this purpose. In addition, key PCIe 3.0 test issues such as multi-lane characterization and tracking dynamic link equalization are easily handled by the SDA 820Zi-A.
Tools such as ProtoSync(TM) and PCIe Decode Annotation permit the test engineer to use his oscilloscope to observe the protocol level DLLP transmission, the physical layer response, the opening of the eye diagram, and track the changes in the Link Training and Status State Machine (LTSSM) diagram. ProtoSync running on a LeCroy oscilloscope is the only setup that captures both the frame level CATC(TM) protocol view along with the physical layer signal associated with it. This capability blends the tests that were typically either in the rigid domains of hardware or software engineers, and speeds debugging of complex problems.
The unique PeRT(3) (TM) Phoenix System addresses three tap de-emphasis to emulate transmitter equalization presets, provides a seamless transition between 8b/10b and 128b/130b encoding and decoding, and also incorporates complete jitter profile. These protocol-aware capabilities are critical for transmitter link equalization response test, receiver link equalization test, and receiver jitter tolerance testing requirements.
LeCroy's PeRT(3), PCIe Decode Annotation and ProtoSync toolsets provide direct validation of 500 ns equalizer response time with visual evidence of the time and traffic during the equalization phase.
Transmitter, receiver, channel and crosstalk measurements can be made with the LeCroy SPARQ. These tests include: Tx and Rx Return Loss, Breakout and Calibration Channel Characterization, Receiver Return Loss, 5 GT/s and 8 GT/s Channel Compliance Testing. The SPARQ is a new class of instrument; the signal integrity network analyzer. SPARQ, which stands for "S-parameters Quick," is a TDR/TDT-based analyzer that measures 40 GHz, 4-port S-parameters with a single button press, and at a fraction of the cost of a VNA.
The Summit T3-16 Protocol Analyzer captures, decodes and displays PCI Express 3.0 protocol traffic between root complex and endpoint devices and features auto-calibration for interposer probing in systems using dynamic equalization.
The Summit Z3-16 Protocol Exerciser generates PCI Express 3.0 traffic at up to x16 lanes as an emulated root complex or endpoint. Engineers can test link up stability, speed/lane size/LTSSM state changes, DLLP and TLP transaction layer operations. Capture PCI Express 3.0 traffic using the Summit T3-16 protocol analyzer and then play back on the Summit Z3-16 analyzer with the device under test for corner case testing.
Further Information
Engineers and technicians who would like to know more can contact LeCroy at 1-800-5LeCroy (1-800-553-2769) or visit the LeCroy web site (www.lecroy.com).
About LeCroy
LeCroy Corporation is a worldwide leader in serial data test solutions, creating advanced instruments that drive product innovation by quickly measuring, analyzing, and verifying complex electronic signals. The Company offers high-performance oscilloscopes, serial data analyzers, and global communications protocol test solutions used by design engineers in the computer and semiconductor, data storage device, automotive and industrial, and military and aerospace markets. LeCroy's 45-year heritage of technical innovation is the foundation for its recognized leadership in "WaveShape Analysis"–capturing, viewing, and measuring the high-speed signals that drive today's information and communications technologies. LeCroy is headquartered in Chestnut Ridge, New York. Company information is available at http://www.lecroy.com.
About PCI-SIG
PCI-SIG is the Special Interest Group that owns and manages PCI specifications as open industry standards. The organization defines and implements new industry standard I/O (Input/Output) specifications as the industry's local I/O needs evolve. The PCI Special Interest Group was formed in 1992 and became a nonprofit corporation, named "PCI-SIG," in the year 2000. Currently, more than 800 industry-leading companies are active PCI-SIG members worldwide. PCI-SIG's current directors are employed by the following PCI-SIG member companies: Agilent, AMD, Dell, HP, IBM, Intel, LSI, NVIDIA and Oracle. For more information about the PCI-SIG and its membership benefits, please visit the PCI-SIG website at http://www.pcisig.com or contact (503) 619-0569 (within the United States).
© 2011 by LeCroy Corporation. All rights reserved. Specifications are subject to change without notice.
PCI-SIG, PCI Express and PCIe are trademarks or registered trademarks of PCI-SIG.
Media contact: Patrick Brightman - SGW (973) 263-5475 Abhishek Sheetal, Product LeCroy Contact: Marketing Manager (845) 425-2000 Customer contact: LeCroy Customer Care Center (800) 553-2769 Website: www.lecroy.com
SOURCE LeCroy Corporation


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I chastised Cousin Jonathan for using the word 'turquoise' this morning in our office. I get a funny feeling about guys who reference the names of colors beyond the Top 10 common color names or so. You start using 'magenta' and 'puce' and 'taupe' around me and I start wondering if you're the right guy to be spotting my mighty 150 lb bench presses at the gym.
But, indeed, we are running out of color descriptions for the bikinis of Rita Rusic, the 51-year old Euro-hottie film producer turned Miami Beach regular and maker of the sexy with the cougar cubs. She's out on the beach attracting much younger men in her skimpy bits of colored cloth barely covering her impossibly hot older woman body several days a week now; she must own 30 different bikinis, in the least. And we've been happy to admire every single one of them. Perhaps chartreuse will be next. Enjoy.


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In about a month's time, I will be traveling to London for work. We are meeting some new clients in person over there, and provided that our initial meeting goes well, I am expecting to spend about three weeks over there working. While this might sound fun, it has been a real challenge finding lodging.
On one hand I could stay at a hotel the entire time, but the truth of the matter is that it would be very expensive. We want to walk away from this client with money in-hand, so wasting it all on a hotel room makes no sense.
There had to be a more economical way for our company to secure lodging for three weeks.
While looking for a solution, I was able to find a good discount at Airbnb. This site provided the opportunity for someone like myself to find lodging at a rate that was much lower than any hotel room I could find. Honestly, I wasn't sacrificing anything by going this route, and I would be just as cozy staying in an apartment.
So, I booked it.
While we have never done this type of booking in the past, staying in an apartment will now be the way we operate moving forward. It just makes sense.