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Answer: ____________________
Note: In this dream of the multi-mineral image, God outlined for all future millenniums the rise and fall of the empires that would have a direct influence on His people.
Note: The astrologers and magicians of Babylon claimed to have supernatural power, but when they could not reveal the dream to the king, they were shown to be impotent imposters. If the king had recalled the dream, they would have simply manufactured a bogus interpretation. In his rage, Nebuchadnezzar commanded all the wise men to be slain-even those who were not present. Among those absent from the first meeting with the king was a God-fearing captive named Daniel, who had just been trained for the king's service.
Note: Daniel requested a little time from Nebuchadnezzar and promised that he would reveal the dream and its meaning. The king, who was still desperate to know the significance of his vision, granted Daniel's request. Then he and his friends appealed to the only Source who could reveal the king's dream. They prayed to the God of heaven.
Note: The rise and fall of empires may appear as if happening by the will of men, but Daniel's prayer of praise clearly reveals the essence of divine intervention. Nothing happens that God is not already aware of and has not allowed. Sometimes we may not understand what is happening in our world today or why, but it is comforting to know that God is still sovereign. Only Daniel could reveal the dream to the king, yet he clearly gives the credit to the One who revealed the dream to him, the God of heaven.
Note: The first thing the king saw was a great image made of the following mineral elements:
Note: The king was regarded as the head of the state. This is why Nebuchadnezzar represented Babylon, the empire that began the prophecy. Neo-Babylon ruled the world from 612-539 B.C. as one of the mightiest empires of antiquity, one that could aptly be described as the head of gold. Notice that the prophecy begins with Daniel's time.
Note: Babylon's supremacy would not last forever. Succeeding kingdoms, inferior to Babylon, would rule in their turn. Just as silver is inferior to gold, so the kingdom that followed Babylon enjoyed diminished glory. Led by Cyrus in 539 B.C., the Medo-Persian empire conquered Babylon and reduced it to ruins. The Medes and Persians were the ruling world power from 539-331 B.C. During their reign, all taxes had to be paid in silver.
Note: The brass kingdom of Greece came into power when Alexander the Great conquered the Medes and Persians at the battle of Arbela in 331 B.C., and Greece remained in power until about 168 B.C. Greek soldiers were called "brazen coated" because their armor was all bronze. Notice how each succeeding mineral depicted in the image is less valuable, yet more enduring than the one before it.
Note: The iron monarchy of Rome conquered the Greeks in 168 B.C. and enjoyed world supremacy until Rome was captured by the Ostrogoths in A.D. 476. Rome is the kingdom that dominated the world when Jesus Christ was born. Notice how Daniel foretold a thousand years of world history with unerring accuracy. The rise and fall of these four world empires: Babylon, Medo-Persia, Greece, and Rome-are clearly foretold in the Bible and proved by the history books.
Note: When the Roman Empire began to crumble in A.D. 476, it was not overtaken by another world power. Instead, barbarian tribes conquered the Roman Empire and divided itjust as Daniel prophesied. Ten of these tribes evolved into modern Europe. They were the Ostrogoths, Visigoths, Franks, Vandals, Alemannians, Sueves, Anglo-Saxons, Heruls, Lombards, and Burgundians. Seven of them still exist today in Europe. For example, the Anglo-Saxons became the English, the Franks became the French, the Alemannians became the Germans, and the Lombards became the Italians.
Note: Through marriage, alliances, and treaties, men have vainly attempted to reunite the European continent. All throughout history, leaders such as Charlemagne, Napoleon, Kaiser Wilhelm, Mussolini, and Hitler have fought to build a new European empire but these words of Scripture have stopped every single would-be world ruler. Revelation 13 tells us there will be another attempt to establish a universal religion, but Daniel's prophecy clearly states that the world will remain politically divided for the rest of Earth's history.
Note: The next great universal kingdom will be the kingdom of heaven, which is described in Matthew 25:31-34.
Note: The stone that was cut without human hands represents God's kingdom. It will not be a conglomeration of earthly kingdoms, but a total replacement Revelation 21:1. The Scriptures declare that when Jesus Christ returns to earth, He will completely consume all the kingdoms of earth and establish an everlasting kingdom Daniel 2:44. What exciting news! Jesus Christ is coming again! All history is moving toward this climactic conclusion, when the Son of God shall return in majesty to bring in the kingdom of everlasting righteousness. King Nebuchadnezzar may have thought that he had defeated the true God when he besieged Jerusalem and plundered the temple Daniel 1:1, 2, but he was shown very quickly that God is ruler over all. Human events are under His control, and ultimately He will win the conflict. Babylon, Medo-Persia, Greece, Rome, and the 10 divisions of the Roman Empire may have sought to usurp divine authority and destroy the people of God, but all earthly kingdoms will eventually be crushed by the coming of Christ. Thank God, He will win the great controversy!
Note: Having seen that God has complete control of world events, even Nebuchadnezzar readily acknowledged that the God Daniel served was above all the heathen gods of Babylon. How quickly the picture had changed! Daniel and his friends, because of their faithfulness to God, were elevated from their initial captivity in Babylon to positions of prominent leadership for the kingdom Daniel 2:48, 49. God always honors those who honor Him 1 Samuel 2:30.
15. Recognizing that God is in full control of earthly events, are you willing to let Him have full control of your life?
This section provides additional information for further study.Gold = BabylonThe head of gold represented Babylon, which was the ruling world power from 612-539 B.C.Silver = Medo-PersiaThe chest of silver represented Medo-Persia, the ruling world empire from 539-331 B.C.Bronze = GreeceThe thighs of bronze represented Greece, the dominant world ruler from 331-168 B.C.Iron = RomeThe legs of iron represented Rome, which enjoyed world supremacy from 168 B.C.-A.D. 476.Iron and Clay = the Divided EmpireThe feet that were partly iron and partly clay represented a divided empire that would not cleave together. No single power has ruled the world since A.D. 476, and it will remain divided until Christ's return.Stone = Christ's Eternal Kingdom, His Word, and His Law


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Battle Of The Atom #1 [Marvel Comics] Review
Posted on September 5, 2013 AT 07:36pm
The first major X-Men event since Brian Bendis took over the bulk of the franchise is here, and with it comes another story about time travel. This time, the X-Men of the future will be making an appearance through four of the X-Universe's titles, all of which will link up into a larger storyline. For the first installment, the All-New and Uncanny teams begin to see the ramifications of what they're doing, and if this new team is any indication, things are not going well for the merry mutants.
It looks like the time-stream is pretty messed up, given not only the events of the major Age Of Ultron event that went through the Marvel Universe, but with the appearance of the original X-Men as well. As they've decided to stick around, this apparently causes even more major problems throughout the X-Men universe, and in spectacularly hypocritical fashion, the future team goes to the present to let everyone know that they really messed up. This gives some interesting looks at some beloved characters, and in the case of a few members of the X-Men, shows some terrific character development. This event is just starting, but so far, it's started strong.
Brian Bendis is taking a pretty big risk with this event, though his last risk (starting this sort of thing off at all with All-New X-Men) paid off pretty well. The concept of time travel can be a hard one to take in sometimes, and now adding it in again could be a bit too complicated for some readers. It's easy to get lost in the story at some points, especially since there are so many characters involved, but thankfully, Bendis knows this universe and how to run it, so it should all work out well.
The art team is pretty large here, but gives off the look of the All-New X-Men pretty well. The entire main team off of that book is here, with Stuart Immonen, Wade Von Grawbadger and Marte Gracia helping out the main artist on the book, Frank Cho. While not as polished looking as the aforementioned title, there is a lot to like about the art style here, as well as the design of some of the future X-Men characters. As a personal peeve, however, there is blatant ignorance of some other aspects of character design (namely one of the Stepford Cuckoos, who changed both style and color of hair in recent issues of Uncanny X-Men, something that is ignored in their appearance here), which does throw off the continuity slightly. This is still a great looking issue, though.
Summary: The big X event has arrived, and while expectations are high, this could get very complicated and blow up rather quickly if not handled well. There are a lot of moving parts in this series, and while the creative team should be able to handle it, there is a high risk/high reward situation going on with this event. The books have been great so far though, and it will hopefully stay that way with this bit of storyline interruption.
Pros: Great artwork, good character development, fun future character design.
Cons: Lack of character design continuity in areas, complicated plot could be challenging.
Grade: B+
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text: Getty Images [ President Obama Won't Release Bin Laden Death Pictures By Chad Hasty May 4, 2011 President Obama has decided not to release the pictures of Osama Bin Laden. Is that the right move? See what Chad thinks and tell us what you think after the jump. Read More|Comment Category: Opinion Tags: osama bin laden, osama bin laden dead, President Obama Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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The Supreme Court ruled 5 to 4 that the government can use Christian prayers to start town meetings, so long as legislators don't discriminate against non-Christians. It's a new chapter in the long-running fight over prayer in public places and on public occasions. NPR's Carrie Johnson explains what happened in the town of Greece, New York.
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"These are beautiful, perfect size for a programs & nice thick paper. They present well & will look wonderful at our wedding. I highly, suggest this product."
"Wedding Paper Divas provides the best professional service! Of all the wedding planning products, this is by far and will always remain the best one!"
"My programs turned out beautiful! I would highly recommend this product. This paper quality is great. They look fantastic in person. I wouldn't change anything."
"used these for a card on the table with one side made into a spy game, and the other into a wedding kiss game. great quality. comes with prefolded crease for ease of use. love them!"
"Designer support was awesome. I was able to communicate via email directly to a designer. That helped a lot. They're doing excellent Job. In addition, our Program contained foreign characters. It came out pretty nicely as well."


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This is an unconventional and original first-class establishment with an informal atmosphere in a tranquil setting on the Maggia, 2 km from Locarno. One of Switzerland's most popular family hotels with 80% of our guests being regulars. Extensive palm garden on 27,000m2, a hotel 9-hole golf course (pitch & putt), tennis, wellness, rest and recreation areas. Weather insurance and rate reductions for 3-generation families.
A comfortable hotel at family-friendly prices. This informal hotel in the Upper Engadine with its 80 rooms for sports enthusiasts and families plus group accommodation is open throughout the year. Newly renovated bathrooms. Free sauna and steam bath. Also available are an internet corner, bike, ski and ski boot room plus garaging. Very centrally located in a tranquil setting close to bus stop and station.
Managed with a personal touch, this family and seminar hotel in Unterwasser is only 3 minutes by foot from the cableways and tennis centre. Compact wellness area with sound wellness - sound relaxation, aqua sound, sound room and sound routes. Hotel's own indoor pool and large sunbathing lawn, sauna, solarium and fitness room. Special organic menu with local produce.


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Unprofessional Fridays: 05/29/2015
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Mortal Kombat X moves forward with a snappier version of the previous game's fighting and some cool new characters, but the story and other features around the edges feel a bit rough in spots.
The ways that Axiom Verge resembles Metroid help set up and drive home the ways that Axiom Verge is most definitely not Metroid.
Hotline Miami's thrillingly brutal gameplay is stretched to the point of breaking in this aesthetically pleasing, but otherwise disappointing sequel.
Game »
consists of 19 releases.
Released Apr 11, 2006
First appearing in Tomb Raider: Legend, Alister is a researcher of ancient civilizations who gives Lara advice via her headset. He is based in Lara's mansion along with Zip.
The primary villain of Tomb Raider: Legend, Amanda was an old friend and archaeology partner to Lara Croft.
Lara Croft's mother, she goes missing in the prologue to Tomb Raider: Anniversary in a Himalayan temple while Lara is still a child.
Not much is known about Anaya, except for she is a Civil Engineer, and a friend of Lara, and was with her duing the tragic Paraiso Incident.
The Rutland name has been attatched to politicians and CEOs for decades - an American aristocracy - so James William Rutland Jr. grew up in an enormous bubble of wealth and privilege. He went to West Point and managed to graduate on his own merits, barely, and it gave him a sense of self-discipline and strength that he finds useful now that he is free of the military. Except for his time at West Point he has never known scarcity or refusal. He is an energetic man who plays hard and has never been lazy in th
The star of the Tomb Raider series and one of the earliest female video game protagonists. British treasure hunter Lara Croft has become one of the most widely recognized game characters in history.
Lara Croft's butler, Winston appears in the mansions of Tomb Raider II, III, Chronicles, Legend and Anniversary.
First appearing in Tomb Raider: Chronicles, Zip is a hacker who helps Lara Croft on her adventures.
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Dil Laga Liya Dil Hai Tumhaara Preity Zinta Arjun Rampal Full Song
- published: 28 Oct 2014
- views: 346
Actress Preity Zinta has denied news reports that she may contest Lok Sabha elections against Congress MP Priya Dutt on a Bharatiya Janata Party (BJP) ticket. According to media reports here, the BJP is keen to rope in Preity to fight...
The Siasat Daily 2014-03-04"Where did you read this? Please tear that paper because it's 100 percent UNTRUE."
Preity Zinta, who is also co-owner of Kings XI Punjab cricket team, has filed a police complaint against her former boyfriend Ness Wadia, alleging that he molested, abused...The Times of India 2014-06-13
Mumbai: Preity Zinta returned to Mumabi on Sunday to record her statement regarding her criminal complaint against former boyfriend Ness Wadia. Zinta is likely to record...Deccan Chronicle 2014-06-22
While most of the Bollywood celebrities are silent over Bollywood actress Preity Zinta's allegation of molestation against her former beau and business partner Ness Wadia,...The Times of India 2014-06-19
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Filmmaker Mahesh Bhatt Saturday called the souring of Preity Zinta and Ness Wadia's 'love story' into a 'hate story', 'unfortunate' after the actress accused her former beau and industrialist of molestation. ALSO READ: Preity Zinta: 5 low points of her life "A Fairy tale love story turns into A HATE STORY! What an unfortunate end to the Priety Zinta Ness Wadia romance," tweeted...The Times of India 2014-06-14
Mumbai: Ness Wadia is more than just Preity Zinta's estranged love. As shocking as it may seem, the industrialist is the great-grandson of Mohammed Ali Jinnah, the founder of Pakistan. Ness Wadia senior was a shipping and textile magnet. His grandfather, Neville, served as the chairman of the Bombay Dyeing textile company until 1977, after which his father Nusli Wadia took...Deccan Chronicle 2014-06-20
Sachin Tendulkar's minor son Arjun Tendulkar may have his statement recorded by Mumbai Police in connection with actress Preity Zinta's harassment complaint against Wadia Group scion Ness Wadia, unconfirmed reports are saying. ALSO READ: Preity Zinta: 5 low points of her life Arjun Tendulkar was apparently present at the Wankhede Stadium when the incident took place, and some...The Times of India 2014-06-19
Bollywood actress Preity Zinta, who has accused her ex-boyfriend and industrialist Ness Wadia of molesting her, Saturday said the intention behind the complaint is to "protect myself". "This is a very difficult time for me and I would like to request the media to pls respect my privacy regarding this matter. My intention is not to harm anyone but only to protect...The Times of India 2014-06-14
Preity Zinta made a lot of headlines with her molestation allegations against ex-flame Ness Wadia. While an FIR was also lodged against Ness Wadia, now it seems that an out of court settlement is being considered. A report in The Telegraph stated that Preity Zinta is keen to sell...The Times of India 2014-06-18
A five-member delegation of Maharashtra Women's Commission led by its chairperson, Chitra Wagh, on Saturday morning met the Marine Drive police officials to find out the action taken against industrialist Ness Wadia in a molestation complaint registered by actor Preity Zinta. Zinta filed a molestation complaint against Wadia with the Marine Drive police on Friday and stated...The Times of India 2014-06-14
In a police complaint filed on Thursday night, Preity has alleged that Ness touched her inappropriately in full public view and hurled abuses at her during the play-off between Punjab and Chennai Actress and Kings XI Punjab owner Preity Zinta has accused her ex-boyfriend industrialist Ness Wadia of sexually harassing her at an Indian Premier League game in Mumbai late last...The Times of India 2014-06-14
Preity Zinta (pronounced [ˈpriːt̪i ˈzɪɳʈaː]; born 31 January 1975) is an Indian film actress. She has appeared in Hindi films of Bollywood, as well as Telugu, Punjabi and English language films. After graduating with a degree in criminal psychology, Zinta made her acting debut in Dil Se.. in 1998 followed by a role in Soldier the same year. These performances earned her a Filmfare Award for Best Female Debut, and she was later recognised for her role as a teenage single mother in Kya Kehna (2000). She subsequently played a variety of character types; her film roles along with her screen persona contributed to a change in the concept of a Hindi film heroine.
Zinta received a Filmfare Award for Best Actress in 2003 for her performance in the drama Kal Ho Naa Ho. She went on to play the lead female role in two consecutive annual top-grossing films in India: the science fiction film Koi... Mil Gaya (2003), her biggest commercial success, and the star-crossed romance Veer-Zaara (2004), which earned her critical acclaim. She was later noted for her portrayal of independent, modern Indian women in Salaam Namaste (2005) and Kabhi Alvida Naa Kehna (2006), top-grossing productions in overseas markets. These accomplishments have established her as a leading actress of Hindi cinema. Her first international film role was in the Canadian film Heaven on Earth, for which she was awarded the Silver Hugo Award for Best Actress at the 2008 Chicago International Film Festival.


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Left-arm spinner Iqbal Abdulla may not have got much opportunities to make it count while playing for Rajasthan Royals in Indian Premier League. However, the 24-year-old is no mood to waste the chances that he is getting for his state side – Mumbai.
On Monday, day two of four-day Capt K Thimmappaiah memorial cricket tournament in Mysore, Abdulla came up with a brilliant five-wicket haul to bundle out Assam Cricket Association for 246 replying to Mumbai's first innings total of 224.
The Abhishek Nayar-led side was eight for no loss with Kevin Almeida (5*) and Akhil Herwadkar (2) at the crease when stumps were drawn.
Mumbai, currently coached by former India player Praveen Amre, will be playing as many tournaments as possible to prepare for the new season.
In another match, making mincemeat of a weak Tripura Cricket Association's bowling attack, KC Avinash (200*) and Shreyas Gopal (150) helped KSCA XI reach a mammoth 506 for 7 decl. in 142.3. In reply, Tripura Cricket Association were 77 for the loss of three wickets in their first innings.


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'The master key, the catalyst, and the magic drug' for SMEs (small and medium enterprises) is information technology (IT) avers Vineet Bajpai in 'The Street to the Highway' (www.jaicobooks.com). For, behind the transformation of traditionally slow family businesses into value-creating modern outfits, French and Italian designers targeting Japanese customers without opening stores in Tokyo, global travellers booking a room in Agra without the help of a travel agent, mid-sized businesses hiring only one accounting professional instead of the usual three earlier, and people manufacturing mobile phone covers becoming millionaires, what Bajpai finds is one fundamental driver – IT.
Big vs small
In the author's view, IT has made as much an impact on SMEs as in the case of larger enterprises. As examples, he mentions how while large companies use ERP the smaller companies have seamlessly moved to user-friendly accounting software; and how the big enterprises have connected global offices through virtual private networks while small companies use the Internet to reach out to millions of international buyers. And even as the biggies invest in enormous CRM (customer relationship management) applications and set up server farms, the micro businesses are using simple software to create customer profile databases, and the young entrepreneur of today carries a laptop!
So, the one clear message is that technology is not and should not be looked upon as the playground of some techno-savvy modern professionals, but as something that is an inevitable new force in our business dynamics, Bajpai urges the business beginners. "If you use it well it could prove to be the greatest step you ever took and give you return on investment that you never imagined. If you miss it, it could push you behind by several laps vis-à-vis your competitors."
SANCTITI model
The book advocates a 'simple assessment and navigation chart to initiate technology implementation' or the SANCTITI model, addressing the four pillars of the organisation's workflow, viz. sales and marketing, operations and internal processes, finance and accounts, and vital support functions in the form of human resources and administration. For each of these, the author lists 'simple and affordable IT enabled solutions' such as online banking and electronic invoicing in the 'finance and accounts' category; and website creation and maintenance, and digital marketing in the 'sales and marketing' category.
Guiding the small entrepreneur through a 'layman's IT audit' for the company by evaluating strengths and weaknesses under each category and then choosing the applications that will be of help in the immediate and foreseeable terms, the author highlights the many 'fashionable by-products' that technology deployment can bring in. "For example, employee swipe cards for entry into your premises is not a big expense. However, apart from the numerous other main benefits, the corporate quotient that it adds to your company's internal branding is quite significant."
Recommended study for the eager SME player.
Keywords: Business development, Technology, Software


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To Die For Roast
Community Recipe from
Recipe Time
Cook Time:
Prep Time:
- 1 (4 -5 lb) beef roast, any kind
- 1 (1 1/4 ounce) package brown gravy mix, dry
- 1 (1 1/4 ounce) package dried Italian salad dressing mix
- 1 (1 1/4 ounce) package ranch dressing mix, dry
- 1/2 cup water
- Place beef roast in crock pot.
- Mix the dried mixes together in a bowl and sprinkle over the roast.
- Pour the water around the roast.
- Cook on low for 7-9 hours.
September 2011
This recipe is a personal recipe added by ENeighbor and has not been tested or endorsed by MyRecipes.
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Nosocomial infections caused by Pseudomonas aeruginosa presenting resistance to beta-lactam drugs are one of the most challenging targets for antimicrobial therapy, leading to substantial increase in mortality rates in hospitals worldwide. In this context, P. aeruginosa harboring acquired mechanisms of resistance, such as production of metallo-beta-lactamase (MBLs) and extended-spectrum beta-lactamases (ESBLs) have the highest clinical impact. Hence, this study was designed to investigate the presence of genes codifying for MBLs and ESBLs among carbapenem resistant P. aeruginosa isolated in a Brazilian 720-bed teaching tertiary care hospital.
Fifty-six carbapenem-resistant P. aeruginosa strains were evaluated for the presence of MBL and ESBL genes. Strains presenting MBL and/or ESBL genes were submitted to pulsed-field gel electrophoresis for genetic similarity evaluation.
Despite the carbapenem resistance, genes for MBLs (blaSPM-1 or blaIMP-1) were detected in only 26.7% of isolates. Genes encoding ESBLs were detected in 23.2% of isolates. The blaCTX-M-2 was the most prevalent ESBL gene (19.6%), followed by blaGES-1 and blaGES-5 detected in one isolate each. In all isolates presenting MBL phenotype by double-disc synergy test (DDST), the blaSPM-1 or blaIMP-1 genes were detected. In addition, blaIMP-1 was also detected in three isolates which did not display any MBL phenotype. These isolates also presented the blaCTX-M-2 gene. The co-existence of blaCTX-M-2 with blaIMP-1 is presently reported for the first time, as like as co-existence of blaGES-1 with blaIMP-1.
In this study MBLs production was not the major mechanism of resistance to carbapenems, suggesting the occurrence of multidrug efflux pumps, reduction in porin channels and production of other beta-lactamases. The detection of blaCTX-M-2,blaGES-1 and blaGES-5 reflects the recent emergence of ESBLs among antimicrobial resistant P. aeruginosa and the extraordinary ability presented by this pathogen to acquire multiple resistance mechanisms. These findings raise the concern about the future of antimicrobial therapy and the capability of clinical laboratories to detect resistant strains, since simultaneous production of MBLs and ESBLs is known to promote further complexity in phenotypic detection. Occurrence of intra-hospital clonal dissemination enhances the necessity of better observance of infection control practices.
Keywords:P. aeruginosa; Nosocomial infection; ESBL; MBL; CTX-M-2; GES-1; GES-5; IMP-1; SPM-1
Pseudomonas aeruginosa is an opportunistic pathogen responsible for a large spectrum of invasive diseases in healthcare settings, including pneumonia, urinary tract infections and bacteremia [1]. For such infections, antimicrobial therapy may become a difficult task, because Pseudomonas aeruginosa is naturally resistant to many drugs, and presents a remarkable ability to acquire further resistance mechanisms to multiple classes of antimicrobial agents, even during the course of a treatment [2]. In this context, infections by P. aeruginosa presenting acquired resistance to beta-lactam drugs are considered one of the most challenging targets for antimicrobial therapy [3], being responsible for high rates of therapeutic failure, increase in mortality, morbidity, and in overall cost of treatment [4-6].
The Ambler's class B beta-lactamases (metallo-beta-lactamases – MBLs) and class A extended-spectrum beta-lactamases (ESBLs) are acquired resistance determinants that present high clinical impact [7,8]. These enzymes, usually codified by genes associated with mobile genetic elements, are matter of major concern with regard to the future of antimicrobial chemotherapy because of its remarkable dissemination capability [9].
MBLs such as IMP, VIM, SPM, GIM and AIM represent the leading acquired mechanism of resistance to beta-lactams in P. aeruginosa. These enzymes hydrolyze the majority of beta-lactam drugs [10] and compromise clinical utility of carbapenems, the most potent agents for treating severe infections caused by multidrug resistant strains [11]. More recently, appearance of ESBLs such as TEM, SHV, CTX-M, BEL, PER, VEB, GES, PME and OXA-type beta-lactamases has become an emergent public health problem, since these enzymes confer resistance to at least all expanded spectrum cephalosporins and compromise efficiency of ceftazidime, an important antibiotic regimen for P. aeruginosa[12-14].
For the establishment of the appropriate antimicrobial therapy and for assessment and control of the spread of drug resistant P. aeruginosa, the molecular detection and surveillance of resistance genes is becoming increasingly important [15,16]. Despite of this, epidemiological data reporting the prevalence of MBL and ESBL producing P. aeruginosa is sparse, due to the inexistence of standardized methods for phenotypic detection of ESBL and MBL production [7,17] and the complexity for the implementation of PCR based methods in the routine of clinical laboratories [17]. In order to overcome this difficulty, a number of commercial rapid molecular tests are being developed that identify pathogens and the presence of genetic determinants of antimicrobial resistance [18,19]. The association of such new technologies with current classical methods may improve the ability of clinical laboratories to provide accurate and fast results that will impact on patient care.
Hence, this study was performed to investigate the carriage of genes codifying MBLs and ESBLs by P. aeruginosa isolated from patients admitted to a Brazilian 720-bed teaching tertiary care hospital. Despite the high rates of carbapenem resistance, genes for MBLs production were not observed in the majority of the isolates. Notably ESBLs codifying genes blaCTX-M-2, blaGES-1 and blaGES-5 were detected in several strains, and the coexistence of blaCTX-M-2 with blaIMP-1, and blaGES-1 with blaIMP-1 in P. aeruginosa was observed, and is presently reported for the first time. These findings underline the emergence of class A extended-spectrum beta-lactamases among P. aeruginosa.
Bacterial isolates
In this study were included a total of 56 P. aeruginosa isolates resistant to ceftazidime, imipenem and/or meropenem, nonrepetitively obtained from patients admitted to a teaching hospital in São Paulo State, Brazil, over a period between June to December 2009. Isolates were obtained from specimens originated from urinary tract, respiratory tract, bloodstream and soft tissue. Clinical specimens were collected in intensive care units, clinical and surgical wards as well as from outpatients as a standard care procedure and were stored for this work. This study was approved by the Ethical Review Board from our institution (Comitê de Ética em Pesquisa – FAMERP) under protocol # 3131/2009.
Susceptibility testing and phenotypic detection of MBL production
Antimicrobial susceptibility to aztreonam, ceftazidime, cefepime, imipenem, meropenem, piperacillin/tazobactam, amikacin, gentamicin, ciprofloxacin, levofloxacin and polymyxin B were determined by the disk diffusion method, following Clinical and Laboratory Standards Institute recommendations [20]. Phenotypic detection of MBLs was performed by double-disc synergy test (DDST) using the 2-mercaptopropionic acid as a MBL inhibitor [17].
Genotypic detection of MBL and ESBL genes
Specific primers and protocols were used to detect and sequence blaTEMblaSHVblaCTX-MblaGESblaKPCblaIMP and blaVIM[17,21-24]. The detection and sequencing of blaSPM-1 was performed using primers previously described [25] and also others specifically designed for this study using DS Gene 2.0 Software (Accelrys, USA). PCR products were purified in ethanol according to previously described methodology [26] and subjected to direct sequencing with the ABI PRISM 3130 automated sequencer (Applied Biosystems, Foster City, CA). The products were aligned with Accelrys Gene 2.0 (Accelrys Software Inc. 2006). Database similarity searches were run with BLAST at the National Center for Biotechnology Information website ( http://www.ncbi.nlm.nih.gov webcite).
Molecular typing
Genetic relatedness was evaluated by pulsed-field gel electrophoresis (PFGE) using SpeI (Fermentas Life Sciences, MD, EUA) with a CHEF-DR II apparatus (Bio-Rad, Richmond, CA, EUA) as described elsewhere [27]. BioNumerics software (Applied Maths) was used for dendrogram construction and clustering, based on the band-based Dice's similarity coefficient and using the unweighted pair group method (UPGMA) using arithmetic averages. Isolates were considered to belong to the same cluster when similarity coefficient was 90% [28]. The visual Tenover criteria were also applied [29].
A total of 80.3% (45/56) of isolates were resistant to the combination piperacillin/tazobactam, 62.5% (35/56) to aztreonam, 78.6% (44/56) to ceftazidime, 96.4% (54/56) to cefepime, 96.4% (54/56) to imipenem, 75.0% (42/56) to meropenem, 51.8% (29/56) to amikacin, 82.1% (46/56) to gentamicin, 78.6% (44/56) to ciprofloxacin and 85.7% (48/56) to levofloxacin. All isolates showed sensitivity to polymyxin B (data not shown). Thirteen isolates (23.2%) presented MBL phenotype by the DDST (Table 1).
Table 1. Antimicrobial susceptibility of carbapenem resistant P. aeruginosa *
The prevalence of isolates harboring MBL genes was 30.3% (17/56). Ten (17.8%) presented the blaSPM-1 gene, and the blaIMP-1 was detected in seven isolates (12.5%). In all thirteen isolates presenting MBL phenotype by DDST, blaSPM-1 or blaIMP-1 was detected. In addition, the blaIMP-1 gene was also detected in three isolates which did not display any MBL phenotype. These isolates also presented the blaCTX-M-2 gene (Table 1). No blaVIM type was detected.
Genes encoding ESBLs were detected in 23.2% (13/56) of the isolates. The blaCTX-M-2 was detected in eleven isolates (19.6%), blaGES-1 was detected in one and blaGES-5 was detected in one isolate. Co-existence of blaCTX-M-2 with blaIMP-1 was detected in three isolates and blaGES-1 with blaIMP-1 in one isolate (Table 1). No blaTEM and blaSHV types were detected GenBank Accession Numbers are provided in Supplemental Material (Additional File 1).
Additional file 1. Gen Bank Accession Number – Sup Material.
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The degree of relatedness among the Pseudomonas aeruginosa harboring MBL and ESBL genes was assessed by PFGE analysis (Figure 1). Eight isolates harboring blaSPM-1 were typed, and by visual inspection all were considered closely related, presenting up to three bands of difference. According to PFGE profiles these isolates were grouped within three clusters (A, B and C). Similarity between cluster A and B was of 89.1%. Clusters A and B presented 87.6% of similarity with cluster C.
Figure 1. Dendrogram of PFGE patterns presented by carbapenem resistant P. aeruginosa included in this study. ER, emergence room; E-ICU, emergence intensive care unit; G-ICU, geral intensive care unit; S-ICU, semi-intensive care unit; C-ICU, cardiology intensive care unit; P-ICU, pediatrics intensive care unit, N-ICU, neonatal intensive care unit N-Dep, neurology department; C-Dep, cardiology department; SC, surgical ward, CI, cancer institute.
The P. aeruginosa harboring blaIMP-1 were distributed among five different clusters (E to I), and isolates harboring blaCTX-M-2 in three clusters (D, E, H). Cluster E included seven isolates presenting similarity of at least 92.3%. Within this cluster, four isolates exhibited blaCTX-M-2, one exhibited blaIMP-1 and two isolates exhibited blaIMP-1 and blaCTX-M-2 simultaneously. One isolate harboring blaCTX-M-2 was placed in cluster D, four isolates harboring blaIMP-1 were placed in clusters F, G, H and I, and one isolate exhibiting blaIMP-1 and blaCTX-M-2 simultaneously was placed in cluster H. Isolates harboring blaGES-1 and blaGES-5 could not be typed.
The pattern of multidrug resistance presented by the P. aeruginosa included in this study was expected, since carbapenem resistant strains exhibit a broad-spectrum resistance to beta-lactams and often present resistant phenotype to additional classes of drugs. Also, acquired ESBL and MBL genes typically group with other drug resistance determinants in the variable region of multi-resistance integrons [30-32]. Furthermore, P. aeruginosa isolated in Latin America, including Brazil, are reported as presenting the higher rates of antibiotic resistance [33]. P. aeruginosa strains resistant to polymyxins were not detected in this study. However, this result should be confirmed by a dilution method, considering that the disc diffusion technique, commonly used in clinical microbiology laboratories is reported to be an unreliable method for evaluating the susceptibility to polymyxins because these drugs diffuse poorly into agar [34].
In this study MBL genes were detected in 26.7% of isolates, indicating that despite the increasing significance of MBL production among P. aeruginosa, this was not the main mechanism of resistance to imipenem and/or meropenem. This reality was previously reported in another Brazilian hospital [35]. In fact, resistance to carbapenems in P. aeruginosa is due not only to the production of carbapenemases, but also to different mechanisms such as upregulation of multidrug efflux pumps, cell wall mutations leading to reduction in porin channels and production of different beta-lactamases [1,11]. Expression of these mechanisms, isolated or in combination, may cause variation in rates of resistance to imipenem and meropenem, observed in this study [5]. The twelve isolates presenting MBL phenotype by the DDST harbored MBL genes (blaSPM-1 or blaIMP-1), confirming the efficacy of this method for the phenotypic detection of MBL producing strains [17,36].
Diversity of MBL among P. aeruginosa varies by regional areas [37]. In this study the 17.5% of the carbapenem resistant isolates presented the blaSPM-1 gene, and blaIMP-1 was detected in 10.5% of the isolates. SPM-1 is in fact the most prevalent MBL in Brazil [38]. In a different way, IMP-1 producing strains have been reported in various Brazilian hospitals in diverse rates [35,39,40].
Molecular typing by PFGE showed a wide diversity of patterns. All isolates exhibiting blaSPM-1, a chromosomally located gene [41,42] presented high coefficient of similarity and closely related PFGE patterns, suggesting a close genetic relationship. This is in agreement with previously described data, showing that the Brazilian SPM-1-producing P. aeruginosa are probably derived from a single clone [43]. According to the same study, even a recent genomic variety recently observed among various SPM-1-producing P.aeruginosa isolates is result of the accumulation of mutations along the time.
Occurrence of blaIMP-1 in P. aeruginosa described in this study is likely a result of gene horizontal transferring, since isolates harboring blaIMP-1 belong to five different clusters. Dissemination of blaIMP among Gram-negative pathogens is mediated by mobile elements of DNA, explaining why the same gene might be detected in different strains. The genes for IMP enzymes are often carried as cassettes within integrons, which facilitate recombination and facilitate rapid horizontal transferring [44-46].
The coexistence of blaIMP-1 with blaCTX-M-2 in P. aeruginosa was, at the best of our knowledge, detected for the first time. Interestingly, the three isolates presenting this combination of genes did not provide a positive result in the DDST test, and were the only blaIMP-1 carriers in which MBL phenotypic detection was unsuccessful. Since ceftazidime is poorly hydrolyzed by CTX-M-2 [31], we could not assume that inactivation of this antimicrobial, used as substrate, may have been responsible for this result. However, simultaneous production of MBLs and ESBLs by the same strain is known to promote further complexity in phenotypic detection [7,47,48]. This result emphasizes the importance of molecular methods for the identification of antimicrobial resistance in multidrug resistant pathogenic bacteria. In this matter, detection of resistance genes by PCR may provide clinically relevant information with positive impact in patient prognosis [18].
The detection of blaCTX-M-2blaGES-1 and blaGES-5 in this study reflects the recent emergence of ESBLs in P. aeruginosa as result of the great dissemination capability exhibited by these genes that occur mostly as part of integron structures on mobile transmissible genetic elements [49-52]. Location of blaCTX-M-2 in P. aeruginosa is believed to be a result of their transfer from Enterobacteriaceae[51]. Recently, a high prevalence of K. pneumoniae harboring blaCTX-M-2 in the same hospital was reported [21], and this may have been the reservoir for horizontal transmission.
Regarding GES-type ESBLs, although these enzymes are not considered as primary β-lactamases in P. aeruginosa, acquisition in conditions of antimicrobial pressure may be beneficial [52]. The blaGES-1 was detected in co-existence with blaIMP-1, and blaGES-5 was detected in a strain resistant to imipenem and meropenem, but presenting no MBL phenotype. Considering that GES-5 presents enhanced hydrolyse activity against carbapenems [10], it is likely that GES-5 production contributed for the carbapenem resistance in this isolate.
Production of MBLs was not the main mechanism of resistance to carbapenems among the studied strains. However, IMP-1 is disseminated among different strains of carbapenem resistant P. aeruginosa, and intra-hospital spread of SPM-1 producing strains was observed. The detection of blaCTX-M-2, blaGES-1 and blaGES-5 and the unique coexistence of blaCTX-M-2 with blaIMP-1 and blaGES-1 with blaIMP-1 exemplify the extraordinary ability presented by P. aeruginosa to acquire multiple resistance mechanisms.
Clonal dissemination of multidrug resistant P. aeruginosa within the hospital was inferred by the observation of strains presenting the identical PFGE profiles infecting different patients, and the occurrence of clonal dissemination in different ICUs and wards. This finding enhances the necessity of better observance of infection control practices, to prevent further dissemination of this challenging pathogen.
Competing interests
The authors declare that they have no competing interests.
Authors' contribution
MP, TC and MCLN carried out the molecular genetic studies, participated in the sequence alignment. MGL, FGR, MTGA, MLN and MCLN participated in the design of the study. MGL, MTGA and MP collected and characterize the isolates. MLN, MTGA, MCLN and FGR analyzed the results. MP, MLN and MCLN drafted the manuscript. All authors read and approved the final manuscript.
This work was supported by a FAPESP grant to MCLN. MLN is supported by FAPESP and CNPq Grants. MLN is recipient of a CNPq Fellowship. MP is a recipient of a CAPES Scholarship.
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Pre-publication history
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Originally written on Helmet2Helmet | Last updated 11/12/14
MIAMI GARDENS, FL - FEBRUARY 07: NFL Commissioner Roger Goodell stands on the field prior to Super Bowl XLIV between the Indianapolis Colts and the New Orleans Saints on February 7, 2010 at Sun Life Stadium in Miami Gardens, Florida. (Photo by Jonathan Daniel/Getty Images)
In the offseason, the NFL's competition committee will consider eliminating kickoffs, an idea recently proposed by commissioner Roger Goodell in the name of player safety. Instead of a team kicking off, the ball would be placed at the 30-yard line and, facing a fourth-and-15 scenario, they'd be given the choice to go for it or punt. The would-be concept has been met with much apprehension, as kickoffs have long been a staple of arguably America's favorite sport. A handful of players and coaches have outwardly opposed the move, but none more so than Browns special teams dynamo Josh Cribbs, who didn't mince words when saying the game is becoming "straight entertainment and no sports." "Then they need to change football leagues or call it a different league if they do that," Cribbs said, via the Cleveland Plain Dealer. "It'll change (the game) drastically. I couldn't ever see that . . . Only play offense and defense, just like intramurals. Play indoors and put flags in our pa...
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Grateful Dead
An unprecedented amount of vines have disappeared over the summer, really it's just 2 maybe 3 people who have taken down the vineyard. One of the vines are the 1973 shn/flac vines - 8 parts in all, which needs full-on re-seeding. There are many more too - I'll look into it more but a lot of the 1990's stuff that Nice Hippy Guy started plus others that Jake R has posted about lately .. again most of these are from those same 2 people. Ridiculous.
Anyways I would love to get these going because they are some of the best vines out there, covering a pretty sweet year. I'll get a hold of ripple1974 because he had posted that he would re-seed parts 1 and 2 to kwitt and then I'd like to follow up with kwitt to see if he can still re-seed part 4, then I can start working on early 73, parts 3,5,6,7. Well, then I can look into the other stuff too as I have time. It's just sad seeing all these vines disappear. I'd also like to clean up some of the lists if you know what I mean! Let it grow!
"The dire wolf collects his due while the boys sing round the fire"
Thanks very much to Caroline.
Shout out to Raymond -- Thanks!
(Such kind folks here!)
Remember that there is a Dylan and the Dead Vine and a Dylan and the Dead Rehearsals vine. I think there may be some confusion in a couple of the D and the D topics.
"Lazy lightning you say you never strike the same place. I want a double dose in any case" ... "You got to hear my supplication. Got to hear me now. A little bolt of inspiration"
I can fill that request for you.... You have a PM....
I can reseed this rehearsal vine onto a dvd with flac files. Just let me know where to send it.
Its down to one disc instead of the original six. PMed TNHG, originator for a reseed also.
I am looking for a SBD copy of the July 10, 1990 Raleigh, NC Carter Finley Stadium show.
I can trade for it. I don't see it vined yet.
UncleJon, after considering that I've never heard the reference in any of the Dead books I have, I think you are likely right. I wonder who sang the song on Lampoon, sure sounded like Jerry. Thanks!
Musky - sorry to say that the song you refer to is a parody - and I doubt it is really the GOGD or Jerry himself. See this link:
If anyone can find information to the contrary I'd be interested!
"when life looks like easy street, there is danger at your door"


text:
Dragon Rider
By Cornelia Funke; Brendan Fraser (Read by)
(Listening Library (Audio), Audio Cassette, 9781400090907)
Publication Date: August 24, 2004
List Price: $33.00*
* Individual store prices may vary.
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Firedrake, a young dragon, receives a frightening warning one night: Humans are planning to destroy the valley in which he lives! All the dragons must flee. Their only refuge is a place above the clouds called the Rim of Heaven--which may not even exist. Firedrake boldly volunteers to go ahead first. As he embarks on his journey, he meets Ben, a runaway boy. Together, the boy and dragon make their way toward the Rim of Heaven, all the while running a step ahead of Nettlebrand, a monster who will stop at nothing to hunt down Firedrake. Their quest will truly become an adventure like no other.
CORNELIA FUNKE is Germany's bestselling children's author after J. K. Rowling and R. L. Stine. In the fall of 2002, she made her brilliant debut in the English language market with the release of The Thief Lord, the enchanting New York Times bestseller. She is also the author of the highly acclaimed novel Inkheart and the picture book The Princess Knight. Ms. Funke lives in Hamburg, Germany, with her family.


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A risk factor is anything that may increase a person's chance of developing a disease. It may be an activity, such as smoking, diet, family history, or many other things. Different diseases, including cancers, have different risk factors.
Although these factors can increase a person's risk, they do not necessarily cause the disease. Some people with one or more risk factors never develop cancer, while others develop cancer and have no known risk factors.
But, knowing your risk factors to any disease can help to guide you into the appropriate actions, including changing behaviors and being clinically monitored for the disease.
Uterine Cancer
What is the uterus?
The uterus, also called the womb, is a hollow, pear-shaped organ located in a woman's lower abdomen, between the bladder and the rectum.
What are parts of the uterus?
- cervix - the narrow, lower portion of the uterus
- corpus - the broader, upper part of the uterus
- myometrium - the outer layer of the corpus; the muscle that expands during pregnancy to hold the growing fetus
- endometrium - the inner lining of the uterus
What is uterine cancer?
Cancers that occur in each part of the uterus have their own names, such as cervical cancer or endometrial cancer, but are sometimes broadly defined as uterine cancer because the structure is part of the uterus. Cancer of the uterus spreads through the bloodstream or lymphatic system. According to the American Cancer Society (ACS), about 42,160 cases of cancer of the uterine corpus (body of the uterus) will be diagnosed in the US during 2009.
What are noncancerous conditions of the uterus?
Some conditions in the uterus, caused by abnormal, rapid, and uncontrolled division of cells, are not cancer. Three of these benign conditions include:
- fibroid tumors - are common benign tumors of the uterine muscle that do not develop into cancer. Fibroid tumors of the uterus are very often found in women in their forties. And, although single fibroid tumors do occur, multiple tumors are more common.
Symptoms of fibroid tumors, which depend on size and location, include irregular bleeding, vaginal discharge, and frequent urination. For fibroids that press against nearby organs and cause pain, surgery may be necessary. Many times, however, fibroids do not cause symptoms and do not need to be treated. After menstrual periods cease, fibroid tumors may become smaller and may disappear altogether.
- endometriosis - is a benign condition of the uterus that is common among women in their thirties and forties, especially women who have never been pregnant. Tissue that looks and acts like endometrial tissue begins to grow in unusual places, such as on the surface of the ovaries, on the outside of the uterus, and in other tissues in the abdomen.
- hyperplasia - is an increase in the number of normal cells lining the uterus. Although it is not cancer, it may develop into cancer in some women. The most common symptoms are heavy menstrual periods, bleeding between periods, and bleeding after menopause.
What are risk factors for uterine cancer?
The following have been suggested as risk factors for uterine cancer:
- age 50 or over
- history of endometrial hyperplasia
- estrogen replacement therapy (ERT)
- being overweight
- diabetes
- hypertension (high blood pressure)
- history of other cancers
The following are known risk factors for uterine cancer:
- history of taking tamoxifen for breast cancer treatment or prevention
- race - African-American women are affected at a rate twice that of Caucasian or Asian women
- history of radiation therapy to the pelvic area
What are the symptoms of uterine cancer?
The following are the most common symptoms of uterine cancer. However, each individual may experience symptoms differently. Symptoms may include:
- unusual vaginal bleeding or discharge
- frequent, difficult, or painful urination
- pain during sexual intercourse
- pain in the pelvic area
- bleeding after menopause
Cancer of the uterus often does not occur before menopause. It usually occurs around the time menopause begins. The occasional reappearance of bleeding should not be considered simply part of menopause. It should always be checked by a physician.
The symptoms of uterine cancer may resemble other conditions or medical problems. Consult a physician for diagnosis.
How is uterine cancer diagnosed?
When symptoms suggest uterine cancer, the following may be used to make a positive diagnosis:
- a detailed medical history - family and personal
- a thorough physical exam
- pelvic examination of the uterus, vagina, ovaries, bladder, and rectum (may include a Pap test)
- biopsy - removal of sample of tissue via a hollow needle or scalpel
- dilation and curettage (D & C) - a minor operation in which the cervix is dilated (expanded) so that the cervical canal and uterine lining can be scraped with a curette (spoon-shaped instrument)
When cancer cells are found, other tests are used to determine if the disease has spread from the uterus to other parts of the body. These procedures may include:
- blood tests
- chest x-rays
- computed tomography (CT or CAT) scans of various sections of the abdomen
- an ultrasound to view organs inside the body
- special exams of the bladder, colon, and rectum
Treatment for uterine cancer:
Specific treatment for uterine cancer will be determined by your physician based on:
- your overall health and medical history
- extent of the disease
- your tolerance for specific medications, procedures, or therapies
- expectations for the course of the disease
- your opinion or preference
Methods of treatment may include:
- hysterectomy - surgery to remove the uterus
- salpingo-oophorectomy - surgery to remove the fallopian tubes and ovaries
- radiation therapy
- hormone therapy
- chemotherapy
Click here to view the
Online Resources of Gynecological Health
Disclaimer - This content is reviewed periodically and is subject to change as new health information becomes available. The information provided is intended to be informative and educational and is not a replacement for professional evaluation, advice, diagnosis or treatment by a healthcare professional. © 2009 Staywell Custom Communications.


text:
But the music legend is now left facing up to new realities as the 'sold out' notices are still to go up on his long-awaited show at Glasgow's Hampden Park in June -- 10 weeks after it was first announced.
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The concert will mark the former Beatle's first Scottish gig in nearly 20 years and tickets, priced between £55 and £85, are understood to have sold steadily, with front row briefs still selling on eBay for £110 a pair.
McCartney's sales compare with that of reformed boy band Take That, who put on a third show at the national stadium after their original two dates sold out quickly last year.
Dozens of fans also camped out overnight in order to obtain tickets for Bruce Springsteen's first gig in Glasgow for 13 years in July 2009, which went on to be a sellout, as did U2's concert at the same venue last year.
Ken McNab, a Glasgow-based expert and author of The Beatles in Scotland, said: "I think the fact that the Hampden show is not sold out yet is simply down to the state of the economy.
"People are having to be very careful with their money, and the tickets are quite expensive.
"I bought four tickets at £80 each. I have seen him several times before, but I did hesitate on the grounds of cost and also McCartney's age -- he is now 67.
"But his shows in America last year were such a fantastic success that I reconsidered and thought that this opportunity might not come again. If his Hampden show is as good as the US ones and I hadn't gone, I would have kicked myself. He is playing at the top of his game, despite his age."
McNab added: "I think McCartney's a realist and that if between 80 and 85% of the Hampden tickets are sold, he will be quite happy with that. In any event I think there will be a last-minute rush for tickets by his hardcore fans. The chance to see a legend like Paul in Scotland might never come again."
The Hampden Park setlist is expected to include a number of Fab Four songs that the Beatles never performed live.
Yesterday in an interview to coincide with the run-up to the gig, on Sunday, June 20, McCartney said: "It's always good to get back to Scotland because I've got a special affection for the wee place. I've never done Hampden before and it's legendary.
"The country is a very special part of the isles we live in. It's had a kind of romantic thing for me since I first went there with the Beatles."
McCartney added that he has "loads of Scottish mates, and the crowds are always great."
The singer-songwriter's last gig in Glasgow was on June 23, 1990, when he played the SECC as part of Glasgow's European City of Culture celebrations.
My desire is always to be here ...
Sir Paul McCartney has several long-standing links with Scotland, chiefly on the Mull of Kintyre. He bought High Park, his farmhouse on Kintyre, in 1966 as a tax-loophole project but didn't actually see it for another 18 months. He finally visited it in the company of actress Jane Asher, his then-girlfriend. His late wife Linda turned it into a family home, and it became a bolthole after The Beatles split up in 1970 He has credited his rustic lifestyle there as saving him from a nervous breakdown. McCartney most famously wrote Mull of Kintyre from the home -- the first single to sell over two million copies in the UK, beating the previous record set by The Beatles' She Loves You. The main road into Campbeltown is supposed to have been the inspiration for The Long and Winding Road, the Beatles' last chart-topping single in the US. A statue to Linda, who died of cancer, is in Campbeltown's main street.


text:
May 24, 2015
The Florida Legislature overwhelmingly passed a bill Monday that it hopes will lower Floridians skyrocketing insurance rates.
The vote now sends the legislation to Governor Charlie Crist for his signature into law. Crist hasn't said yet whether or not he will sign it into law. He says he still must review the details, but it appears to deliver what he called "meaningful, broad-based" relief that he has demanded.
Lawmakers say the average Florida homeowner could see savings of about 22 percent, although it would vary widely on where they live and who their insurance company is.
The state created insurer of last resort, Citizens Insurance, the average savings will be about 18% for high risk coastal residents. Other citizens customers would see much lower savings, probably in the range of 5%.
But, Citizens Insurance customers would also get a 21% rate increase reversed.
And, the legislation also cancels a 56% rate increase Citizens Insurance customers would have been hit with this year.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


text:
Oddly Enough
Branded golf balls were a mistake, Ireland's former bank regulator says
DUBLIN - Ireland's financial regulator, whose "timid" supervision was criticized for not halting the country's banking crash, produced branded golf balls to promote itself before the office was overhauled, a parliamentary inquiry heard on Thursday.
Recent Oddly Enough News
Townsend lets cat out of the bag, why hotels are best
PARIS - American player Taylor Townsend, when deciding whether to stay in a cramped Parisian hotel or rent a private apartment during Roland Garros, opted for the former.
German grandmother gives birth to quadruplets at age 65
BERLIN - A 65-year-old German grandmother gave birth to quadruplets at a Berlin hospital this week, with the three boys and a girl born prematurely at 26 weeks being in good health and having a good chance of survival, German TV network RTL reported on Saturday.
Milwaukee man pronounced dead, then moves and breathes - authorities
- First responders preparing to take the body of a Milwaukee man pronounced dead to the morgue got a jolt when the man suddenly began moving and noticeably breathing, authorities said on Friday.
Could another English king be buried under a car park?
LONDON - Just three years after the extraordinary discovery of King Richard III under a car park, researchers think another medieval English monarch might be found buried beneath a parking lot and are hoping to find him.
Bowwow wow! Dog domestication much older than previously known
WASHINGTON - Genetic information from a 35,000-year-old wolf bone found below a frozen cliff in Siberia is shedding new light on humankind's long relationship with dogs, showing canine domestication may have occurred earlier than previously thought.


text:
NewsJuly 11 2012
Local firemen fight Black Hills fire
Members of the Kennebec Volunteer Fire Department traveled to the Black Hills to help fight the White Draw , located northeast of Edgemont. The fire burned around 9,000 acres and was finally contained Friday, July 6.
Chaz Bowar and Jake Longville were on site when they were demobilized and released Friday.
The Kennebec Fire Department has a contract with the South Dakota Department of Ag, Wildland Suppression Division to assist with fires within the state. They also have an agreement to help on the National Grasslands. The fire department receives financial compensation for fighting fires which has helped the Kennebec firemen pay for their firehall.
According to fire chief Don Manger, when dispatched the department sends a unit, which includes two firemen and a vehicle, to the assigned fire for a minimum of 14 days.
"Everybody has a job so we split the time up between firemen," said Manger. Steve Manger and Chaz Bowar were the first firemen to volunteer to go, followed by Chad Urban and Rod Bowar.
The firemen have to be certified in wildland fire suppression and hold a red card to prove they passed the physical fitness test to maintain their contract with the state.
Four members of the North Carolina Air National Guard died in the crash of a C-130 plane Sunday,, July 1 that was assisting with the White Draw fire.
- Remebering those who gave all
- Presho HS reunion set
- Lyman holds Commencement
- To cancel or not cancel branding, that is the torturing question
- GLF host successful Spring event
- Lyman School election set for June 16
- Flowers for the young at heart
- That "One Guy" to entertain at Vivian's Syttende Mai
- Lyman AAU celebrates season
- Lyman alumni to meet July 25
- A night in Old Hollywood
- GLF Annual Spring Event set for May 9th


text:
- Musician's Friend Best Selection, Price & Service. Guaranteed.
Call our Gear Heads
at: 800-449-9128
Call our Gear Heads
at: 800-449-9128
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Selmer Bore Oil Prevents moisture absorption in wood. Tasteless, odorless. 1-1/2 oz. bottles.
Great for removing dust from around and under keys, the Selmer Key Cleaning Brush keeps woodwind keyworks...
The Selmer Super Sling Hyman is a strap for alto or tenor sax constructed of sturdy break- and stretch-proof...
No-stick powder. Easy-to-use. Small amount stops pads from sticking. Stainless, odorless, greaseless. 1 1/2...
Keep the neck receiver and octave key of your Selmer saxophone(s) in perfect working condition with a Selmer...
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text:
Konpora Kid (Series)Konpora Kid (Series) (1983) Anime Series by Dave Koch
This page has been viewed 6 times this month, and 258 times total.
- Konpora Kid AnimeAnime SeriesSeries
- Traditional Animation
- Tôei Company Ltd.
- Cartoon Characters: Daigoro Harumi JR (JR), Class Five.
- Directed By Juzo Morishita, Yuji Endo, Tatsuo Higashino, Yoshikata Nitta, Shigeyasu Yamauchi; more Directors ...
- Animated By Yasuhiro Yamaguchi, Tatsuhiro Nagaki, Masami Shimoda.
- Written By Takao Koyama, Shigeru Yanagawa, Kenji Yoshida.
- Music: Kohei Tanaka.
- Series Began Airing around 1983.
- Originally Aired on TV Asahi (Japan).
- Running Time: 25 minutes.
- Color
- Japan
Cartoon Summary:
We do not have a synopsis for this cartoon; why don't you send us one?
Cartoon Production Information:
This TV series ran for 26 episodes. Based on Masahide Motohashi's manga, which was serialized in such publications as "Shonen Magazine." In the midst of the TV series, JR and Class Five also appeared in... (more)
Cartoon Video:
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Cartoon Comments:
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text:
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Top Apps
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Console Based Program to Admin HL Steam based Servers , it allows to admin a lot of servers from ssh console (putty or whetever terminal emulator you want). Its perfect to allow clans admin their HL server, change betwen mods, stop, start server and many0 weekly downloads
Hardcore IDS
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UnixConf is a System-Configuration-Tool for Debian(in future RedHat,SuSE,Open- & FreeBSD to) written in Shell-Script(sh/ash). It is a X/Dialog based Modular System-Tool created for Admins, to Configure your Base-System, Network, Servers,...0 weekly downloads
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text:
Nobody does it better
(Sing it, baby)
Makes me feel sorry for the past
(I know they feel sorry too)
Nobody does it quite the way you do
Bobby, you're the best
(Thank you, baby, thank you)
(Yes, you are, yes, you are)
(I love you, baby)
Laid back
You know you are
(Baby, sing, yeah)
Oh, you know you are
(Baby, sing, yeah)
You the best, baby, you the best, baby
(Are you ready? You think they ready?)
(You think they ready, baby?)
Get 'em, baby
(Think they ready?)
Get 'em, baby, get'em, baby
Go, baby, go


text:
Sunday's NFL-Playoff Summary
Seahawks 24, Redskins 14
LANDOVER, Md. (AP) -Wild-card weekend is over in the NFL playoffs, and Seattle's Russell Wilson is the lone rookie quarterback remaining.
And, Wilson's Seahawks made a pretty good case that they might be here a while.
Wilson teamed with Marshawn Lynch to lead Seattle to a 24-14 comeback victory Sunday over the Washington Redskins, who finished the game without Robert Griffin III - their star rookie quarterback who reinjured his right knee.
The Seahawks (12-5) overcame a 14-0 first-quarter hole - their biggest deficit this season - and will visit the top-seeded Atlanta Falcons (13-3) next Sunday.
Ravens 24, Colts 9
BALTIMORE (AP) - Anquan Boldin set a franchise record with 145 yards on five receptions, including the clinching touchdown, as Baltimore beat Indianapolis 24-9 in Sunday's AFC wild-card game.
The previously struggling Ravens defense was staunch, inspired no doubt by star linebacker Ray Lewis appearing in his final home game before retiring. Baltimore never let Colts standout rookie quarterback Andrew Luck get comfortable.
AFC North champion Baltimore (11-6) will play at AFC West winner Denver next Saturday. The Broncos beat the Ravens 34-17 three weeks ago.
The loss ended the Colts' turnaround season in which they went from 2-14 to the playoffs in coach Chuck Pagano's first year in Indianapolis (11-6). Pagano missed 12 weeks while undergoing treatment for leukemia and returned last week.
In Baltimore, Ray Lewis and the Ravens eliminated Andrew Luck, the No. 1 overall pick, and the Indianapolis Colts with a 24-9 win. The victory delayed Lewis' retirement for at least another week.
The other playoff games next weekend are Green Bay at San Francisco (Saturday) and Houston at New England (Sunday).
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Carroll: Seahawks CB Richard Sherman sorry about postgame rant
Browns to interview Bills' Pettine with Broncos' Gase out of running
NFL talking to 49ers about sideline hit vs Seahawks in NFC title game
Falcons hire former Chiefs GM Pioli as assistant general manager


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The word "wrought" is an archaic past participle form of the verb "to work," and so "wrought iron" literally means "worked iron". Wrought iron is a general term for the commodity, but is also used more specifically for finished iron goods, as manufactured by a blacksmith or other smith. It was used in this narrower sense in British Customs records, such manufactured iron being subject to a higher rate of duty than what might be called "unwrought" iron. Cast iron, unlike wrought iron, is brittle and cannot be worked either hot or cold. Cast iron can break if struck with a hammer.
In the 17th, 18th and 19th centuries, wrought iron went by a wide variety of terms according to its form, origin, or quality.
While the bloomery process produced wrought iron directly from ore, cast iron or pig iron were the starting materials used in the finery forge and puddling furnace. Pig iron and cast iron have high carbon content which make them very brittle, but they have a lower melting point than iron or steel. Cast and especially pig iron have excess slag which must be at least partially removed to produce quality wrought iron. At foundries it was common to blend scrap wrought iron with cast iron to improve the physical properties of castings.
For several years after the introduction of Bessemer and open hearth steel there were different opinions as to what differentiated iron from steel, some thinking it was the chemical composition and others believing it was whether the iron heated sufficiently to melt and "fuse". Fusion eventually became generally accepted as relatively more important than composition below a given low carbon concentration.9 Another difference is that steel can be hardened by heat treating.read more


text:
The world's smallest bear almost resembles a small, cuddly dog – but don't mistake them for the family pet. Meet the man who is protecting the world's smallest bear.
With 22 million licensed divers in the world, the underwater tourism industry is big business. But you don't have to be a diver – or even a swimmer – to get up close to marine life.
In a video filmed at Borneo's Camp Leakey, David Attenborough gets a unique perspective from wild orangutans that have been rescued from captivity.
Orangutans, scenic escapades and religious architecture create an experience as unique as the island itself.
From unique wildlife and tropical islands to untouched jungle and isolated hill tribes, few destinations match Malaysian Borneo's natural drama.
View image of The Danum Valley Conservation Area, a dense lowland rainforest in Sabah, Borneo, is home to thousands of animal species, from monkeys and apes to elephants and amphibians. The 20 miles of nature trails that cut through the park are perfect for spotting wildlife. (Mattias Klum/National Geographic Stock) (Credit: Mattias Klum/National Geographic Stock)
Borneo's Danum Valley Conservation Area is home to a wide variety of animals, from endangered elephants to rare giant amphibians.
There are several ways to access this remote state's pristine beauty without going through expensive, officially-designated tour companies or paying hefty fees.
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