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Oxypower: herbal supplement for mitochondrial efficiency and cardiovascular health.
The mitochondrion plays an important role in health. Its dominant role in the body is to produce adenosine triphosphate (ATP) or energy. Besides energy production, it is also associated with processes such as regulating the cell cycle and cell growth. Damage to the mitochondrial or to the mitochondrial DNA has been linked to conditions like cardiovascular disease, neurological disorders, diabetes, and aging.
Many factors have been implicated in mitochondrial dysfunction, including oxidative stress, vascular endothelial cell impairment, and DNA damage. When there is an overabundance of reactive oxygen species (ROS) or free radicals and the body is unable to clear these toxins fast enough, then oxidative stress and mitochondrial damage result. Cells are normally able to defend themselves against ROS damage, but in many cases, a supplement is needed as aid. Natural antioxidants can help clean free radicals from the system.
There are many plants that have antioxidant properties. OxyPower contains the herbs Hippophae rhamnoides and Rhodiola rosea, both of which can effectively protect cells against oxidative stress, promote mitochondrial efficacy as well as protect and repair DNA. (1), (2)
Oxypower Research
Cell Oxidative Damage Study
There are many factors that cause oxidative stress. One is the oxidation and reduction in cells due to free radicals' producing substances that cause cell damage. For instance, hydrogen peroxide, one of the most powerful oxidizers, can penetrate cell membrane and can be catalyzed into hydroxyl compounds (OH). These free radical compounds cause oxidative stress to the cells and hamper the efficacy of the mitochondria. This can eventually contribute to atherosclerosis, diabetes, hypertension, and coronary heart disease.
Antioxidants are widely used to protect cells from damage and to combat oxidative stress. Coenzyme Q10 (CoQ10) is one of the more common antioxidant supplements on the market today. In the following in vitro study on human umbilical vascular endothelial cells (HUVECs), CoQ10 was used as a point of comparison for OxyPower's antioxidant and cell protection properties.
In the study, hydrogen peroxide ([H.sub.2][O.sub.2]) was used to induce damage to HUVECs (positive control). CoQ10 or OxyPower, at varying doses, was given to respective groups to determine how much cell protection each of these substances offers. Based on Table 1, HUVEC proliferation increased with an increasing dose of OxyPower. Comparing it with CoQ10, the 100[micro]g CoQ10 + [H.sub.2][O.sub.2] group provided 60% cell growth while 75 [micro]g OxyPower + [H.sub.2][O.sub.2] group provided over 63% cell growth. To calculate how much better OxyPower protects the cells, the following formula was used:
Table 1: In Vitro Study: OxyPower vs. CoQ10 on Cell Protection HUVEC proliferation Cell Protection Group A value % % Negative Control (no 0.703 [+ or -] 0.013 100 - damage) Positive Control 0.342 [+ or -] 0.014 48.6 - ([H.sub.2][O.sub.2]) (damaged cell) CoQ10 + 0.422 [+ or -] 0.008 60.0 11.4 [H.sub.2][O.sub.2] (100 [micro]g) OxyPower + 0.373 [+ or -] 0.010 53.1 4.5 [H.sub.2][O.sub.2] (37.5 [micro]g) OxyPower + 0.443 [+ or -] 0.030 * 63.0 14.4 [H.sub.2][O.sub.2] (75 [micro]g) OxyPower + 0.523 [+ or -] 0.009 * 74.4 25.8 [H.sub.2][O.sub.2] (150 [micro]g) OxyPower + 0.609 [+ or -] 0.013 * 86.6 38.0 [H.sub.2][O.sub.2] (300 [micro]g) A value is the spectrometric measurement for cell proliferation; * p < 0.05
(%[proliferation.sub.OxyPower + H2O2 group]--%[proliferation.sub.positive contorl]
(%[proliferation.sub.OxyPower + H2O2 group]--%[proliferation.sub.positive contorl]
According to the results, 75[micro]g OxyPower provides 26% higher cell protection than 100[micro]g CoQ10 from free radical cell damage.
OxyPower: Antioxidant Function
OxyPower's antioxidant properties were further tested in animal studies by measuring the activities of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA). These are biomarkers for oxidative stress.
SOD counteracts the damaging effects of free radicals, protecting the cell from toxicity. GSH protects cells from oxidation by free radicals and peroxides. In Table 2, both of these markers increased with an increasing dose of OxyPower, suggesting that it protects the cells from oxidative damage.
Table 2: In Vivo Study: OxyPower vs. CoQ10: Antioxidant Properties Group SOD (U/ml) GSH-Px (U/ml) MDA (nmol/ml) Positive control 161.46 425.6 3.43 Negative control 129.49 405.12 7.04 CoQ10 (83 mg/kg) 167.88 483.19 3.49 OxyPower (83 mg/kg) 163.03 460.46 3.61 OxyPower (250 mg/kg) 177.93 465.66 3.33 s OxyPower (750 mg/kg) 179.95 469.20 3.24
MDA, on the other hand, is an end product of the degradation of lipids by reactive oxygen. This biomarker is used to measure the level of oxidative stress in an organism: a lower MDA level indicates lesser cell damage. In Table 2, the MDA level progressively decreased with an increasing dose of OxyPower.
OxyPower on Lipid Metabolism and Cardiovascular Health
Endothelial cells line the entire circulatory system, facilitating normal blood flow throughout the body as well as vasoconstriction and vasodilation, among other processes. VEC damage plays a vital role in many cardiovascular diseases. This is why understanding how to protect and repair VECs is at the forefront of cardiovascular research.
Abnormal lipid metabolism results in hyperlipidemia and oxidative stress which, in turn, can lead to vascular endothelial cell (VEC) damage. One of OxyPower's functions is to facilitate lipid metabolism by regulating cholesterol and triglyceride levels. This reduces oxidative stress and helps protect VECs from damage.
In an in vivo study, hyperlipidemia was induced in rats. (3) There were 60 healthy male rats in the study, equally divided into five groups. The rats in the positive control group were given an ordinary diet. The rats in negative control group were fed a high-cholesterol diet to induce hyperlipidemia. The rats in the OxyPower groups were also given a high-cholesterol diet and then given OxyPower at different doses of 83, 250, and 750 mg/kg and CoQ10 at the dose of 83 mg/kg.
After four weeks, the effects of OxyPower and CoQ10 on lipid levels, the antioxidant system, and the endothelial system were evaluated through the measurement of total cholesterol, triglyceride, very low density lipoprotein, atherogenic index, plasma endothelin, and nitric oxide.
The first set of results compared the effect of OxyPower and CoQ10 on lipid levels and on the atherogenic index. In Table 3, OxyPower reduced cholesterol levels by 11.32%, 20.09%, 30.41% at the dose of 83 mg/kg, 250 mg/kg, and 750 mg/kg, respectively, compared to the negative control group. OxyPower also reduced triglyceride levels in all three groups at an average rate of 30.59% after four weeks.
Table 3: In Vivo Study: OxyPower on Lipid Levels after Four Weeks Group Cholesterol (Mg/Dl) Triglycerides (Mg/Dl) Positive control 49.50 84.14 Negative control 75.01 139.95 OxyPower (83 mg/kg) 66.52 * 93.89 * OxyPower (250 mg/kg) 59.94 * 100.97 * OxyPower (750 mg/kg) 52.20 * 96.55 * * p < 0.01
As part of the study, the low density lipoprotein (LDL) level was also measured. LDL transports cholesterol and triglycerides in the bloodstream. In this study, the LDL-C indicates the amount of cholesterol in LDL and is a measure of how much LDL is driving the development of atherosclerosis. Very low density lipoprotein (VLDL) is a precursor to LDL. Similar to LDL, VLDL is also a marker for atherosclerosis progression.
In Table 4, as expected, both LDL-C and VLDL-C are high in the negative control group. In the OxyPower groups, both indicators progressively decreased with an increasing dose of OxyPower.
Table 4: In Vivo Study: OxyPower vs. CoQ10 on LDL-C and Atherogenic Index Group LDL-C (mg/dl) VLDL-C (mg/dl) Al Positive control 8.51 16.24 1.14 Negative control 29.39 28.22 3.80 OxyPower (83 mg/kg) 27.46 18.95 2.68 OxyPower (250 mg/kg) 19.72 20.11 2.32 OxyPower (750 mg/kg) 13.53 18.95 1.77
The atherogenic index (Al) is another marker for the formation of fat deposits in the vascular walls. Looking at Table 4 again, OxyPower performed better at reducing the Al than CoQ10. Compared with the negative control group, OxyPower reduced Al by 29.47%, 38.95%, and 53.42% at doses of 83 mg/kg, 250 mg/kg, and 750 mg/kg, respectively.
These results demonstrate that OxyPower can regulate the lipid metabolism in hyperlipidemic rats, inhibit oxidative modification, and protect the vascular endothelial system.
OxyPower on Nitric Oxide and Endothelin
Cardiovascular health can also be determined through the nitric oxide (NO) and endothelin (ET) levels. Both are produced in the vascular endothelial cells but their functions are opposite. NO has antithrombotic properties. It relaxes the blood vessels, making it more flexible. It can also inhibit involuntary muscle contractions and reduce blood platelet adhesion. ET, on the other hand, is a vasoconstrictor and aids in platelet agglutination. Higher NO levels and lower ET levels are obviously ideal for the prevention of atherosclerosis. However, when VEC damage is present, NO decreases while ET increases.
Results of the study demonstrate that rats on a high lipid diet (negative control group) have low NO and high ET levels (Table 5). When OxyPower was given, their NO levels increased and their ET levels decreased.
Table 5: In Vivo Study: OxyPower vs. CoQ10 on Nitric Oxide and Endothelin Group NO ([mu]mol/L) ET (pg/ml) Positive control 37.43 301.74 Negative control 24.69 328.78 OxyPower (83 mg/kg) 37.02 325.77 OxyPower (250 mg/kg) 37.44 310.86 OxyPower (750 mg/kg) 39.24 290.85
OxyPower on Mitochondrial Function and Energy
It has already been shown that OxyPower reduces oxidative stress by increasing biomarkers that protect the cells and lowering factors that contribute to cell damage. This allows OxyPower to improve mitochondrial efficiency, specifically in the better utilization of oxygen and glucose in cells (Figure 1).
In the mitochondrial electron transport chain, OxyPower improves the mechanism that transports fatty acids, glucose, and protons across mitochondrial membrane to produce ATP, the form of energy used by cells. Since the factors that hinder mitochondrial efficiency (e.g., oxidative factors) have been reduced or eliminated, OxyPower is able to work very quickly in producing energy as well as in preventing fatigue.
Unlike coffee and other drinks that provide energy temporarily, OxyPower provides a more lasting effect by helping the body to use stored energy more efficiently at different levels.
First, it increases the oxygen-carrying capacity of red blood cells, making more oxygen available to different organs and tissues. As a result, energy increases. In this capacity, OxyPower may be beneficial for individuals with fatigue, anemia, and cancer.
Second, OxyPower increases serum glycogen levels. Glycogen is the storage form of carbohydrates in the liver and muscle tissues. When energy is needed, it is converted readily into glucose. When glycogen levels are low, fatigue occurs during exertions such as in exercise. In a mice study, glycogen in the OxyPower group was 20.35%, 35.6%, and 53.2% higher than the control group at doses of 2.5, 5.0, and 10 ml/kg, respectively. This means that OxyPower increases the body's energy storage, helping to combat fatigue.
In another mice study, liver glycogen in mice was tested. Since there is no significant difference in glycogen level in this test (Table 6), it means that OxyPower is able to utilize energy longer and much more efficiently, without burning much glycogen. This further illustrates OxyPower's ant/fatigue function.
Table 6. In Vivo Study: OxyPower on Liver Glycogen in Mice Group mg/100g liver tissue Glycogen increase (%) Control 1967.5 + 338.4 -- OxyPower (0.167 g/kg) 2187.4 + 274.7 11.2 OxyPower (0.333 g/kg) 2116.9 + 303.2 7.6 OxyPower (0.999 g/kg) 2237.3 + 255.1 13.7
Third, OxyPower works at a much deeper level, the mitochondrial level, to be exact. Since the mitochondria are the cells' principal source of energy, they have to be working efficiently to produce optimal energy. Mitochondrial damage or dysfunction will obviously hamper energy production and lead to fatigue. It has already been demonstrated that OxyPower improves mitochondrial efficiency by reducing oxidative stress and VEC damage.
Serum Lactic Acid Study
Lactate (lactic acid) is the end product of the glycolysis (the metabolic breakdown of carbohydrates and sugars to produce energy) under anaerobic conditions. In a condition called lactic acidosis, the production of too much lactic acid causes damage to the mitochondria. Acidosis can occur when there is inadequate oxygenation in the tissues. During bursts of vigorous activity, such as exercise, oxygen supply to the tissues can become depleted. Lactate then escapes from muscle cells into the blood and is rebuilt into glucose in the liver during recovery. However, if it is not cleared fast enough, acidification can result in fatigue and muscle soreness. In order to prevent this from happening, there should be adequate oxygen supply to the tissues and the accumulation of too much lactic acid should be avoided.
An animal study demonstrates that OxyPower reduces serum lactic acid. In the study, 40 mice were divided equally into 4 groups: the control group and 3 groups given 0.25 ml/kg, 0.125 ml/kg, and 0.0625 ml/kg OxyPower, respectively, for 8 weeks. At the end of the study, the serum lactic acid level was measured.
Results of the study (Table 7) revealed that the dosage of OxyPower was inversely proportional to the level of lactic acid in the serum. Since serum lactic acid is a determinant of anaerobic metabolism, this means that an elevated level signifies insufficient oxygen delivery to meet organ and tissue demands, especially during vigorous activity. Since lactic acid levels decreased with an increasing dose of OxyPower, this suggests that OxyPower is able to improve oxygen delivery in the organ and tissues, promote mitochondrial efficacy, and prevent cell damage.
Table 7: In Vivo Study: OxyPower on Serum Lactic Acid after 8 Weeks Group Mice (N) Lactic acid (mg/100ml) Control 10 28.68 Oxypower (0.0625 ml/kg) 10 26.87 Oxypower (0.125 ml/kg) 10 21.32 * Oxypower (0.25 ml/kg) 10 18.77 ** ** p<0.01, * p< 0.05
OxyPower on Energy (Antifatigue)
In another animal study, a swimming test was utilized to determine the effect of OxyPower on endurance of mice. Forty mice were divided into 4 groups of 10 mice each. Mice in the OxyPower groups were given 0.0625 ml/kg, 0.125 ml/kg, and 0.25ml/kg OxyPower, respectively, for 8 weeks. At the end of 8 weeks, the mice were given weights and allowed to swim. Their endurance was then measured by calculating the length of time the mice stayed afloat.
It is clear from the results in Table 8 that higher doses of OxyPower provide greater effect on endurance. Even mice given the lowest OxyPower dose were able to swim longer than mice in the control group.
Table 8: In Vivo Study: OxyPower on Swimming Endurance after 8 Weeks Group Mice (N) Avg Endurance in pool (secs) Control 10 243.6 Oxypower (0.0625 ml/kg) 10 283.1 Oxypower (0.125 ml/kg) 10 363.1 * Oxypower (0.25 ml/kg) 10 483.6 ** ** p<0.01, * p<0.05
OxyPower on Muscle Strength
In another study, the muscle strength of mice with or without OxyPower was measured using the climbing test. The same number of mice was involved. Mice in the OxyPower groups were given 0.0625 ml/kg, 0.125 ml/kg, and 0.25 ml/kg OxyPower, respectively. At the end of 8 weeks, the mice were placed in a pool of water with a pole to which they could climb and hold. To gauge their muscle strength, the time it took for the mice to hold onto the pole without falling into the water was measured.
The study clearly shows that with increasing dosage of OxyPower, the mice were able to hold onto the pole much longer (Table 9). This indicates that OxyPower increased muscular strength, allowing the mice to hold on to the pole longer without falling back into the water.
Table 9: In Vivo Study: OxyPower on Muscle Strength after 8 Weeks Group Mice (N) Avg Holding time (secs) Control 10 306.7 Oxypower (0.0625 ml/kg) 10 382.4 * Oxypower (0.125 ml/kg) 10 489.6 ** Oxypower (0.25 ml/kg) 10 568.1 ** ** p<0.01, * p<0.05
Antihypoxia Study
In this study, it will be demonstrated that OxyPower prevents oxygen deprivation in tissues (antihypoxia). Preventing hypoxia plays an important role in mitochondrial efficiency. As mentioned, lactic acidosis occurs when oxygen supply to the tissues is not adequate during vigorous activity. Since acidosis can eventually damage the mitochondria, it is important to avoid this occurrence by ensuring that there is enough oxygen supply to the tissues.
An in vivo study compared OxyPower with the extract of Rhodiola algida, an herb known for its antihypoxia effects. There were 50 mice involved in the study, divided equally into five groups. Mice in the Rhodiola group were given 0.125 g/kg Rhodiola. Mice in the OxyPower groups were given 0.0625 ml/kg, 0.125 ml/kg, and 0.25 ml/kg OxyPower, respectively. At the end of 8 weeks, the mice were placed in a water-filled chamber with progressively decreasing oxygen content to simulate a hypoxic environment. Their survival time in the chamber was then measured.
As the results show (Table 10), OxyPower at the dose of 0.0625 ml/kg, which is half the dose of Rhodiola, produced comparable results with Rhodiola in terms of survival time. At the same dose as Rhodiola (0.125 ml/kg), mice in the OxyPower group survived 15.9% longer. With 0.25 ml/kg of OxyPower, survival time was 31.8% higher than the Rhodiola group and 48.7% higher than the control group.
Table 10. In Vivo Study: Antihypoxia effect of OxyPower vs. Rhodiola Group Mice (N) Survival time (mins) Control 10 23.4 Rhodiola algida (0.125 g/kg) 10 26.4 Oxypower (0.0625 ml/kg) 10 26.5 * Oxypower (0.125 ml/kg) 10 30.6 * Oxypower (0.25 ml/kg) 10 34.8 ** ** p<0.01, * p<0.05
Clearly, OxyPower has a more effective antihypoxic function than Rhodiola alone, making it beneficial for those with lung problems and those with oxygen deficiency conditions.
Informal Human Experiment on the Antihypoxia Function of OxyPower
An informal experiment was performed to determine OxyPower's effect on respiratory function, fatigue, and general well-being at high altitudes. In the experiment, 15 men and women (ages 7 to 69) participated in a mountain hike. All the participants stayed at an elevation of 12,500 feet for three nights. Various doses of OxyPower were given at varying time lengths before and during the hike.
Six of the participants (a 7-year-old girl, a 34-year-old female, two 36-year-old females, a 24-year-old male, and a 51-year-old male) were nauseated and suffered from headaches by the time they climbed up. They were given two 250 mg soft gels of OxyPower. After only 13 minutes, the 34-year-old female's headache had alleviated. Within two hours, headaches were alleviated and nausea was relieved in all six participants. With continued use of the OxyPower, they did not feel any symptoms during their three-day stay at 12,500 feet.
All the other participants had similar results even with the variety of doses they have taken. A 39-year-old male took four 250 mg soft gels daily for a month while a 43-year-old male only took two soft gels. An 8-year-old and a 13-year-old male only took one OxyPower soft gel. A 69-year-old male took OxyPower for 3 months but stopped taking it 10 days before the trip. Despite stopping 10 days before the trip, the effect of OxyPower still lingered because he did not have breathing problems or other high altitude symptoms.
It is also worth mentioning two similar cases:
M. C, a 50-year-old female, has been mountain hiking twice in the past two years. Both times, she went up to 10,000 ft in elevation and suffered from altitude sickness. During her last trip, she took OxyPower for four days prior to the hike. She reported having no symptoms of illness for the entire three days of her trip, even at 13,000 ft.
T. C, a 55-year-old male, had gone to Tibet (elevation 12,500 ft) about 12 years ago. During that trip, he had to have an oxygen tank to help him breathe because of the high elevation. For the present hike, he took two OxyPower soft gels twice per day before and during the trip. For the entire time he was in Tibet, he did not even have any breathing difficulty except when he walked fast.
All of the above cases illustrate that the antihypoxia function of OxyPower is very beneficial for reducing symptoms of altitude sickness.
OxyPower on DNA
In the last 20 years, numerous studies have unearthed the mysteries of the DNA, shedding light on how DNA is changed in cancer, aging, and other health conditions. It has become a consensus among scientists that diseases occur because of damage to DNA. Normally, the cells' DNA can naturally repair mutations and other changes. However, in cases like cancer, the repair genes are unable to do so.
According to animal studies, genetic deficiencies in DNA repair can lead to increased incidence of cancer, premature onset of aging-related diseases, and a shorter lifespan. This is because the rate of DNA damage exceeds the ability of the cell to repair it. Eventually, the accumulation of damage can overwhelm the cell, causing the above-mentioned conditions. (4-7)
Furthermore, mitochondrial DNA damage increases susceptibility to aging and neurodegenerative diseases, including Alzheimer's disease and age-related macular degeneration (AMD), according to a report by Frank Shallenberger, MD. Apparently, a deficiency in repairing mitochondrial DNA damage contributes to the development of retinal degeneration. (8) Antioxidant therapies have been shown to delay the progression of AMD. (9)
Mitochondrial DNA mutations may also underlie Alzheimer's disease, Parkinson's disease, and other disorders that are common among senior citizens, says Doug Wallace, director of the University of California Irvine's new Center for Molecular and Mitochondrial Medicine and Genetics. "If we could find a way to protect mitochondrial DNA, either with drugs or by using gene therapy to transplant it to the nucleus, it could not only extend our life spans but prevent many of the diseases we associate with aging as well." (10-12)
Studies have shown that protection against oxidative stress and repair of mitochondrial DNA damage may have a strong impact on the prevention and treatment of Alzheimer's disease. (13) In this regard, OxyPower may have a viable application.
An in vitro study demonstrates that OxyPower may have protective and reparative functions on the DNA. The single cell gel electrophoresis assay, also known as the comet assay, was used in this instance to detect DNA damage. Thymidine kinase DNA of TK6 human lymphoblast cells was analyzed using electrophoresis. To induce DNA damage, [K.sub.2][Cr.sub.2][O.sub.7] was added to the cells.
DNA damage was evident in the TK6 human lymphoblast cell without OxyPower, shown as the comet tail (Figure 2A). Twenty four hours after adding OxyPower, it is clear from the results that DNA damage was repaired, as evidenced by the absence of the comet tail (Figure 2B).
In another in vitro study, OxyPower was compared with Mitomycin C (MMC), a chemotherapeutic agent. (14) Similar to the previous study, the comet assay was again used to detect DNA damage to the cells with or without OxyPower. The percentage of cells with tailing signifies the amount of damage while the length of the tailing signifies the degree of damage.
As illustrated in Table 11, MMC alone induced significant DNA damage, with tailing in 46.8% of the TK6 human lymphoblast cells and an average tail length of 17.65 pm after 24 hours. As expected, there was very minimal damage in the OxyPower-only group. In fact, the percentage of cells with tailing in this group (3.6%) is less than even the negative control group (7.4%), signifying cell protection. In the OxyPower + MMC group, only 4% of the cells had damage while the average tail length was only 4.55 [micro]m. This means that even in the presence of a substance that harms the DNA, OxyPower's DNA protection property is still potent. Overall, this study indicates that OxyPower has both protective and reparative functions on the cells.
Table 11: In Vitro Study: Effect of OxyPower on Mitomycin C-Induced DNA Damage 0 hours 24 hours Group Cells with Tail length Cells with tail Tail length tail (%) ([mu]m) (%) ([mu]m) Negative 7.5 4.66 7.4 4.56 control MMC (0.0005 78.6 18.56 46.8 17.65 mg/ml) OxyPower 6.5 4.56 3.6 4.54 (5.0mg/ml) OxyPower + MMC 5.1 4.56 4.0 4.55
With the many studies behind its different functions, OxyPower proves to be a wide-ranging supplement, with applications in cardiovascular disease, energy, mitochondrial health, and DNA protection and repair.
All these different functions have a common link: the mitochondrion. Mitochondria are the power plants of cells, containing enzymes, ribosomes, tRNA, and mitochondrial DNA. While the major role of the mitochondria is energy production, it also contains reactive oxygen species (ROS) that may potentially cause damage. Mitochondrial dysfunction has been associated with conditions such as cardiovascular disease, neurological disorders, and diabetes. Moreover, impaired mitochondrial function and loss of efficiency are related to fatigue and aging.
Preserving the integrity of the mitochondria and minimizing oxidative stress that contributes to mitochondrial damage are viable goals for minimizing the risk of developing cardiovascular disease and other disorders.
Oxidative stress is considered one of the major factors of mitochondrial and vascular endothelial damage. Minimizing this stress is vital to preventing many cardiovascular diseases such as atherosclerosis as well as neurological disorders like Alzheimer's disease. In recent years, the application of antioxidants for these conditions has been the subject of many studies.
In the in vivo antioxidant study, it is clear that OxyPower increases biomarkers (SOD and GSH) that protect cells from damage caused by free radicals. This is evident in the cell protection study where, even in the presence of a reactive oxygen species like hydrogen peroxide, the addition of OxyPower still enabled the cells to proliferate.
Antioxidants are especially beneficial in cardiovascular health because damage to vascular endothelial cells occurs when there is oxidative stress. Besides free radicals, lipids can also pose a risk for cardiovascular health. It is widely known that high cholesterol and high triglycerides are risk factors for atherosclerosis and stroke. Additionally, there is a feedback loop that occurs among lipids, oxidative stress, and mitochondrial damage. When lipids accumulate, their oxidized forms are more easily retained in the cells and cause oxidative stress, leading to mitochondrial damage. Mitochondrial damage, in turn, causes more lipid accumulation.
OxyPower blocks this feedback loop through all three paths: reducing lipid levels, minimizing oxidative stress, and preventing mitochondrial DNA damage.
In the hyperlipidemia mice study, OxyPower clearly reduced cholesterol level by an average of 20.61 % and triglyceride level by an average of 30.59% after four weeks. The study also tested the atherogenic index (Al), a measure of fat deposits in the blood-vessel walls. Results show that with an increasing dose of OxyPower, the Al value decreases, suggesting the reduction of fat deposits in vascular walls.
Moreover, OxyPower increases nitric oxide (NO) levels and reduces endothelin (ET) levels. NO enhances blood vessel flexibility, reduces clumping of platelets, and prevents involuntary muscle contractions while ET increases vascular contractions. These functions have important roles in maintaining cardiovascular health.
These results are very significant especially for individuals with cardiovascular disease, such as atherosclerosis, stroke, and congestive heart failure.
OxyPower's reduction of oxidative stress was determined through the indicators superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA). In vivo studies show that OxyPower reduces oxidative damage by increasing SOD and GSH, both cell protective markers, while lowering MDA, a lipid peroxide product that contributes to cell damage.
In vitro studies show that OxyPower protects and repairs DNA. In the two studies, OxyPower was able to minimize DNA damage caused by the DNA-altering substances, [K.sub.2][Cr.sub.2][O.sub.7] and Mitomycin C. OxyPower's ability to protect and repair DNA as well as its potent antioxidant effect is not only useful for neurodegenerative and aging disorders but also for cardiovascular conditions.
With its many functions, it is not surprising that OxyPower has energy-boosting and antifatigue properties. It works on many different levels, including the mitochondrial level, to produce lasting energy, not the temporary energy that one gets from coffee, for example. Furthermore, it is able to combat fatigue by preventing the loss of oxygen supply to tissues (as evident in the serum lactic acid and antihypoxia studies) and by utilizing stored energy more efficiently without burning too much glycogen.
While further clinical studies are needed to firmly establish OxyPower's effects on energy, oxidative stress, and DNA repair, the evidence presented here is compelling enough to warrant a closer look at this supplement.
(1.) M Basu, R Prasad, P Jayamurthy, et al. Antiatherogenic effects of seabuckthorn (Hippophae rhamnoides) seed oil. J Phytomedicine. 2007;14(1);770-777.
(2.) Kurkin VA. The chemical composition and pharmacological properties of rhodiola plants. Pharm Chem J. 1986;20(10):123.7.
(3.) Ma HY, Chen JY, Zhang LS. Study on protective effect of Tianji soft capsule on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats. Submitted for publication.
(4.) de Boer J et al. Premature aging in mice deficient in DNA repair and transcription. Science. 2002;296(5571):1276-1279.
(5.) Dolle ME et al. Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res 2006;596(1-2):22-35.
(6.) Espejel S et al. Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep. 2004;5(5):503-509.
(7.) Helleday T et al. DNA repair pathways as targets for cancer therapy. Nature Reviews Cancer. 2008;8:193-204.
(8.) Jarrett SG, Lin H, Godley BF, Boulton ME. Mitochondrial DNA damage and its potential role in retinal degeneration. Prog Retin Eye Res. 2008;27(6):596-607.
(9.) Feher J et al. [Metabolic therapy for early treatment of age-related macular degeneration]. Orv Hetil. 2007;148(48):2259-2268
(10.) Wang AL, Lukas TJ, Yuan M, Neufeld AH. Increased mitochondrial DNA damage and down-regulation of DNA repair enzymes in aged rodent retinal pigment epithelium and choroid. Mol Vis. 2008;14:644-651.
(11.) Pedersen PL. Mitochondrial matters of the brain: amyloid formation and Alzheimer's disease introduction. J Bioenerg Biomembr. 2009;41(5):403-4-5.
(12.) Leuner K et al. Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease? Antioxid Redox Signal. 2007;9(10):1659-1675.
(13.) Muller WE, Eckert A, Kurz C, Eckert GP, Leuner K. Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects. Mol Neurobiol. 2010;41(2-3): 159-171.
(14.) Chen W, Zou SY, Zhang LS. Evaluation of mutagenicity and anti-mutagenicity of two health foods by Comet Assay. Mod Prev Med. 2008;35(1):1-3.
Dr. Tsu-Tsair Chi is the founder of Chi's Enterprise Inc., a leading nutraceutical company. He earned his PhD in biochemistry from Waksman Institute of Microbiology at Rutgers State University and then became a board-certified naturopathic physician. Beginning in 2002, Dr. Chi became a qualified instructor for continuing education (CE) courses for licensed health-care professionals. To learn more, please visit www.chi-health.com or call 714-777-1542.
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Kwanzaa is celebrated in story and song, for "A Season's Griot" with host Madafo Lloyd Wilson. This year's program features youth as the special guest griots, reading their own original and traditional stories. Plus, an original composition by the show's poet laureate, Beverly Fields Burnette. Wednesday 12/26 at 7pm, Thursday 12/27 at 1pm. (Your Legal Rights and Open Air return next week.)

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Hazel McCallion skips hearing on conflict of interest allegation
Facing the possibility of removal from office if found guilty of conflict of interest for the second time, Mississauga Mayor Hazel McCallion has failed to defend herself, a lawyer for the resident who brought allegation argued Monday.
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Facing the possibility of removal from office if found guilty of conflict of interest for the second time, Mississauga Mayor Hazel McCallion has failed to defend herself, a lawyer for the resident who brought allegation argued Monday.
"The best evidence of the mayor's state of mind comes from (McCallion), not from a law clerk," Thomas Richardson told Ontario Superior Court Justice John Sproat in Brampton on Monday.
Richardson is representing Elias Hazineh in the case, which alleges that McCallion voted at the Region of Peel in 2007 on development charge issues that could have saved her son's company up to $11 million. McCallion was found guilty of conflict of interest in the early '80s after she voted on land acquisition issues that could have benefited her personally.
In response to the extensive affidavits that outline Hazineh's application against McCallion, she did not submit any of her own evidence and did not attend Monday's hearing. Instead, a law clerk, whom Richardson described as having "no knowledge" of the matter, submitted a seven-page affidavit on McCallion's behalf. Richardson attacked the "unsigned, unsworn" information in the affidavit as being riddled with factual errors, which he systematically pointed out.
"The respondent (McCallion) as of today has failed to respond," he told Sproat.
McCallion's lawyer, Freya Kristjanson, told the Star she could not comment during a "live trial" on why the mayor did not respond to the allegations herself.
Kristjanson spent her turn at the podium arguing that the case should be an open trial with witnesses and cross-examination, instead of the documentary process that Richardson has argued for, where such cases see all the evidence submitted in writing for a judge to determine the verdict.
Kristjanson also argued that all of the applicant's evidence based on testimony from the Mississauga Judicial Inquiry should be thrown out because such testimony cannot be used in a court case.
McCallion's longtime political foe, former MP and Mississauga Councillor Carolyn Parrish, submitted an affidavit in support of the conflict of interest charge. She was at Monday's hearing.
"I found it remarkable, facing possible removal from office, that the mayor did not deign to present an affidavit in her own defence. What is needed is an expeditious resolution to a deeply troubling situation."
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I-28 Vinyl Headliner Replacement
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Re: I-28 Vinyl Headliner Replacement
I stand corrected on the material. You are also correct that the 1/4" open cell foam on the back of my existing vinyl would saturate every winter and take most of the summer to dry out. It never dripped but it sure rotted out the seams and metal zipper pulls. Thus my choice of breathable fabric. I'm intrigued by the idea of a spray-on insulation rather than glued-on chunks of styrofoam. Maybe with some practice I can get a fairly consistent thickness but foam-in-a-can and I are not good friends when it comes to fine work. Any product or application suggestions?
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Bryan Stork leads Seminoles' offensive line of veterans
AUG 08, 2013 1:27p ET
That has changed dramatically in the past few years.
The Seminoles' offensive line is now one of the team's strengths, a group with four returning starters that in 2013 will protect a first-year starting quarterback but also open a path for a talented group of tailbacks.
Bryan Stork has seen all of the changes firsthand. Stork, a senior, is the unquestioned leader of the group, starting 27 career games (first at guard but then at center in 2012).
"From the past two years to now, I feel way more comfortable," Stork said. "I'm more relaxed."
The same can be said for all of Florida State's linemen, who clearly have benefitted from being thrown into the fire when the unit faced so many injuries in 2011 (four freshmen started the bowl win against Notre Dame).
After once struggling to protect the quarterback and allowing 41 sacks in 13 games in 2011, Florida State trimmed that number all the way down to 26 sacks in 14 games last season.
Florida State also threw for 3,709 yards and ran for 2,882 yards in 2012, one of just five teams in the Football Bowl Subdivision that put up at least 3,000 yards passing and a minimum of 2,800 yards rushing. It also showed that the offensive line was adept at both buying Manuel time and opening up rushing lanes for the likes of James Wilder Jr., Devonta Freeman and Chris Thompson.
The difference in the offensive line from 2011 to 2012 is night and day.
"Now we know each other," Stork said. "We can look at each other and tell each other what we're thinking."
Stork is a candidate for the Rimington Award, which is given each year to the nation's top center. He graded out at a team-leading 85.6 percent in 2012, and Phil Steele's preseason magazine ranks Stork as the No. 2 center.
The versatile Stork has had quite the football career already. He played tight end in high school and has already started in college at guard. But Stork may also see playing time at right tackle in 2013.
Florida State coach Jimbo Fisher feels that Stork's long-term prospects are at tackle, which is a position of need in the NFL. But Stork's value is also in the fact that he can play every offensive line position, something that will make him a hot commodity in 2014 when the NFL Draft approaches. With NFL roster limitations, it helps that Stork can play every position on the line.
But for now, Stork is entrenched at center. Until he's asked to move elsewhere.
"I'm playing it day by day; I don't care (where I play)," Stork said. "I just want to play football do what I love. I don't ever want to stop. The day I stop is going to be a sad day, you know?"
It doesn't look like that day will be anytime soon.
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2013 Sailing Season
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I got some unasked-for time to go sailing starting last week, so I set sail on Friday and motored and drifted and drifted and motored as far as Swan Creek Friday evening. Drifted to Reed Creek Saturday, which was beautiful. Got a lot of chores done on the boat since I was moving so little. After spending the entire morning becalmed, I almost sailed back home Sunday afternoon to avoid what sounded like a day of dismal weather on Monday, but I wouldn't have made it back before dark, and it would have been a beat the whole way, so I just sailed back and forth on the Chester that afternoon. I waited out the bad stuff in Davis Creek near Cacaway Island, then headed home with building winds yesterday, covering the 35 miles home by early afternoon.
It's funny how in one day you can sail in everything from deck-washing wind and chop to nearly glassy calm weather. This is especially true coming off the Bay and going up the Severn - the wind can be blowing like stink out on in the open water, and then nothing but intermittent gusts as soon as you pass the corner at the Naval Academy. All in all, though, I think yesterday may have been the best day I've ever had sailing, it was so perfect coming back up the Severn.
My outboard stopped pumping water on Monday, and then a heron landed on it when I was below decks and took a big crap on it to add insult to injury. I saw and heard so much wildlife during this trip it was almost annoying: honking, squawking, hooting, screeching, splashing, and evening something braying at a nearby farm. No leaf blowers, generators, or traffic rumble.
Oh yeah, meals: 1 can of Chef Boyardee ravioli, one can of lite beef soup, two packets instant microwave macaroni and cheese (don't have a microwave on my boat, so I boiled it on the stove), 1 packet of ramen, some leftover Turkish kofte and vegetables, two apples, four or five granola bars, one pint of mixed nuts and raisins, one beef sausage stretched out over three days, five eggs, two cups of oatmeal, some coffee, and instant cocoa. And popcorn. I lost nearly five pounds.
1964 Whitby 25
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Siena Frames
Sterling Bilaminato Braid Frame
Please select an available size.
Please select a size.
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Description: Sterling Bilaminato Braid Frame:
- Sterling silver-plated aluminum frame with wood backing
- Clear lacquer coating keeps frame from tarnishing
- Glare-resistant glass lens
- Dual easel for horizontal or vertical display
- Each holds one 2x3 inch picture
- Measures 6 inches in length by 4 inches in width
- Wipe with a dry cloth
Material: Sterling Silver
Brand: Siena Frames


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Though the remnants of giant creatures continue to be dug up the world over, North America remains a playground for paleontology enthusiasts. From casual dinosaur fans to hardened fossil hunters, there is something for everyone at these destinations.
The Montana Dinosaur Trail runs through Montana and includes 15 museums, state parks and other dinosaur-themed destinations.
On the western end of the trail, the Two Medicine Dinosaur Center is known for its research and education programs, ranging from as brief as three hours to as extensive as 10 days. The center is at the site where the first baby dinosaur bones in North America were discovered and is home to the Guinness World Records holder of the longest scientifically reconstructed Seismosaurus halli, or Earth-shaking lizard.
MORE INFORMATION: 800-238-6873 or mtdinotrail.org
The Jurupa Mountains Cultural Center offers dinosaur eggs, fossils and mineral exhibits up close. The nonprofit family learning center provides activities that focus on hands-on education, including workshops on the art of lapidary, collecting specimens and dinosaur digs. It is also the location of the largest collection of Chinese dinosaur eggs on display in North America. A half-mile round-trip hike takes visitors to Dinosaur Mesa. Scheduled guided tours are available for the general public Saturdays.
Forty miles to the east, Claude Bell's iconic roadside dinosaurs, Ms. Dinny and Mr. Rex, are found off I-10. These large apatosaurus and Tyrannosaurus rex sculptures have been seen in numerous films and music videos since 1964.
MORE INFORMATION: 951-685-5818 or jurupamountainsculturalcenter.net
Dinosaur Provincial Park, a UNESCO World Heritage site, is regarded as one of the best dinosaur fossil beds in the world. Forty species of dinosaurs from the Cretaceous period have been unearthed here since 1884.
The Badlands Bus Tour takes visitors on a two-hour guided experience around the park, while the Centrosaurus Bone Bed Hike is a 2.5-hour tour into a restricted area where more than 300 Centrosaurus skeletons have been identified. The Camels End Coulee Hike offers views of the flora and fauna of the badlands. Daily tours of the Field Station Laboratory are offered at 1:30.


text: Publications Search Results Users may wish to consult What's Included in the Bibliography. Results 1 - 1 Results per page: 25 50 100 Sort by: Pub Date (newest) Title Recent Additions Author Clear All Pub. Year Citation 2004 Parker, Karen F. Industrial Shift, Polarized Labor Markets and Urban Violence: Modeling the Dynamics Betweenthe Economic Transformation and Disaggregated Homicide. Criminology. 42, (3), 619-645. Full Text Options: DOI Worldcat Google Scholar Export Options: RIS EndNote XML [1]


text: Some fallout from the last Rays and Yankee game in which a Yankee catcher was run over in a hard play at the plate. Two ejections from the game so far as a result of Phillips throwing at Longoria. I am sure more info is coming. Baseball season is really here now.


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China's legislature weighs in on online data privacy
On 28 December 2012, the Standing Committee of the National People's Congress, China's legislature, weighed in on the subject of data privacy with its promulgation of the Decision on Reinforcing the Protection of Network Information. For the most part, the Decision merely affirms legal obligations already put in place by prior legislation. The most significant aspect of the Decision in regard to data privacy is the fact it was issued by the NPC, as China's legislature, signaling the importance being placed on data privacy at the highest level of China's law making system.
Click on the link above to download this Morrison & Foerster briefing.
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- Reviews
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MacGyvering Your Way Through a Gig
October 20, 2010
How to survive when everything goes wrongRead More
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Tales of rare findsRead More
15 Things to Leave off Your Bucket List
August 17, 2010
John Bohlinger gives a list of things you should avoidRead More
What Does the Horn Hand Mean?
July 20, 2010
Looking into the meaning of the ubiquitous "horn hand," an icon of rock ''n'' roll.Read More
JBovier EMC Electric Mandolin Review
June 16, 2010
JBovier offers a solution for those playing mandolin in a bandRead More
The Unbreakable Rule
June 16, 2010
John fights through the pain to adhere to the unbreakable rule: the show must go on.Read More
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May 18, 2010
Does playing into your 80s and 90s keep you alive longer?Read More
The Nashville Number System Demystified
April 15, 2010
The Nashville Number System is used by nearly every working musician in Nashville. Learn it!Read More
Is the Album Extinct?
March 11, 2010
Is the popularity of music downloads making finding hidden gems in an album a thing of the past?Read More
The Cult of Tone
March 11, 2010
How Vanity, Iconography, and Chance Dictate Six-String SpiritualityRead More


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Newport Jazz Festival
Newport Jazz Festival: Darcy James Argue's Secret Society live
Airs Tuesday, April 2 at 9 p.m. The composer Darcy James Argue has steadily been rescuing the big band from the dustbin of anachronism through a combination of enormously open ears and a gigantic well of patience. But it's paying off: After the release of his debut album Infernal Machines, the greatness of the Secret Society became an open secret, and his "co-conspirators" have now recorded a much-anticipated sophomore album. Eighteen of them give us a taste, including a peek at the Brooklyn Babylon project, originally designed for live music and live painting.
Set List:
Blow-Out Prevention
Selections from Brooklyn BabylonTransit
This concert is made possible by NPR Music and was recorded at the 2012 Newport Jazz Festival.
Darcy James Argue, composer/conductor
Erica von Kleist, woodwinds
Rob Wilkerson, woodwinds
Sam Sadigursky, tenor saxophone/woodwinds
John Ellis, tenor saxophone/woodwinds
Josh Sinton, baritone saxophone/woodwinds
Seneca Black, trumpet
Tom Goehring, trumpet
Matt Holman, trumpet
Nadje Noordhuis, trumpet
Ingrid Jensen, trumpet
Mike Fahie, trombone
Marshall Gilkes, trombone
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Sebastian Noelle, guitar
Gordon Webster, piano
Matt Clohesy, bass
Jon Wikan, drums/percussion


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Outpatient Care
N.C. Children's Hospital's outpatient offerings in Chapel Hill include general and primary pediatric care clinics and subspecialty care in nearly every pediatric subspecialty imaginable. Satellite outpatient sites include the N.C. Children's Specialty Clinic, located on the Rex Healthcare campus in Raleigh, and more than two dozen subspecialty clinics throughout the state in places like Asheville, Burlington, Cary, Charlotte, Fayetteville, Greensboro, Lumberton, Raleigh, Rutherfordton, Tarboro and Wilmington, among others.
- Children's Outpatient Center - Chapel Hill—Located on the ground floor of N.C. Children's Hospital in Chapel Hill, the Children's Outpatient Center provides comprehensive pediatric services via primary care and pediatric subspecialty care clinics.
- N.C. Children's Specialty Clinic - Raleigh—The N.C. Children's Specialty Clinic is a satellite extension of the outpatient pediatric clinic at N.C. Children's Hospital in Chapel Hill, helping address the statewide shortage of pediatric subspecialists by extending and expediting highly specialized care miles closer to home for thousands of Triangle-area families and those living in eastern North Carolina.
- Other "Satellite" Outpatient Clinics—Physicians from N.C. Children's Hospital treat children at more than two dozen satellite pediatric subspecialty clinics each year, avoiding the burden of long, expensive commutes to Chapel Hill for specialty diagnosis and follow-up care. Looking for a satellite clinic offered by a particular pediatric subspecialty? Choose a clinical category from our pediatric specialties list to learn more about each program's specific outpatient offerings.


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Chaparral Energy Withdraws Senior Notes Private Placement
OKLAHOMA CITY, Feb. 16 /PRNewswire/ — Chaparral Energy, Inc. ("Chaparral") today announced that it is withdrawing a previously announced $400 million private placement of senior notes. The proceeds were to have been used to repay indebtedness under its existing credit facility and for general corporate purposes.
About Chaparral Energy
Chaparral Energy, Inc. is an independent oil and natural gas production and exploitation company, headquartered in Oklahoma City. Since its inception in 1988, the Company has increased reserves and production primarily by acquiring and enhancing properties in its core areas of the Mid-Continent and the Permian Basin. Beginning in 2000, Chaparral expanded its geographic focus to include Ark-La-Tex, North Texas, the Gulf Coast and the Rocky Mountains.
Forward Looking Statements
This news release contains forward-looking statements. Forward-looking statements give our current expectations or forecasts of future events based on assumptions and estimations that management believes are reasonable given currently available information. Information on risks and uncertainties that could cause actual results to differ materially from those contemplated by the forward-looking statements is available in Chaparral's filings with the Securities and Exchange Commission.
Contact: Chaparral Energy Joe Evans, CFO 405-478-8770 firstname.lastname@example.com Investor Relations Counsel: Lisa Elliott / email@example.com Anne Pearson / firstname.lastname@example.com DRG&E: 713-529-6600
SOURCE Chaparral Energy, Inc.


text: Publications Search Results Users may wish to consult What's Included in the Bibliography. Results 1 - 1 Results per page: 25 50 100 Sort by: Pub Date (newest) Title Recent Additions Author Clear All Pub. Year Citation 1994 Penrod, John Robert . Empirical Essays in the Economics of Labor and Health. Dissertation, Princeton University. Export Options: RIS EndNote XML [1]


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Literary Award Winning Author Kurt KammKurt has kindly offered signed copies of all his books for a limited time.…Continue
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My publisher gave me a challenge...and it sure was a daunting task! Having transcribed to computer, searched and successfully published two of my deceased mother-in law's books and several short…Continue
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China, the eve of the September 11 attacks. A powerful cyber weapon is about to be released. Only one man can stop it ...
Journalist and SIS (MI6) contract agent George Quant arrives on the run in Beijing. Estranged from Karen, his Moscow-based handler, George is thrust into Asia's…
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Free RingtonesFree Mobile VideosFree Mobile ThemesFree Mobile GamesFree Mobile SoftwaresFree Mobile WallpapersFree Online GamesFree Wallpaper Creator
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Pick your Skate Boarder and grind the streets!OBJECTIVE You are skating through the city to catch up to a friend,watch out for ...
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A simple game of catching 33 scrambling numbers. But check out how fast can you get them.
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Think being a clown is easy? Try to catapult your clowns and catch the balloons!
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Help the fisherman catch the same species of fishes with his hook to gain points.


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Window seats have gained widespread popularity in recent years for their light-filled spots and cozy alcoves that offer comfortable places to kick back and relax. Let's face it, we are drawn to the small, little enclaves in a home. These tightly-fitted nooks and crannies not only provide architectural interest but serve as functional seating and in some cases storage – not to mention space boosters. In addition to providing useable seating, window seats offer comfort as well as serene views to the outdoors. As long as there is a walled niche area in front of a window, a window seat can be used in any room in the house – from kitchen banquettes to bathroom voids. Window seat cushions can take a bland, awkward space and turn it into a comfy and decorated one that may just end up being a much-loved room focal point. When deciding on what to do with an existing nook or if you are thinking of adding a new one, consider the following 3 ways to make over the seating area using a custom cushion.Read More
Design Ideas
4 steps to transforming a room using custom curtains
Selecting a curtain or drape style for an interior room can be rather challenging for a diverse number of reasons. Unless you're an interior designer by trade or have a keen eye for decorating, choosing a window covering for an indoor space can leave you guessing which style is best suited for your home's unique character.Read More
Creating a room that grows with your child
Decorating a kid's room can be a big task, especially when you may not have the resources to decorate at every stage of your child's budding life. Eventually, children grow up and so does their taste in style. So why not choose a pallet that will serve your child well into the future. Believe it or not the pallet you choose has a huge impact on how accommodating and flexible your room will be in the coming years. Here are some suggestions to consider before you create that over-the-top fantasy room for your child.Read More


text: Marijuana is not a bad drug at all, in fact is has various types of medical usage. A whole completely different story is the governmnet labels it as illegal because if it was legal their Rockefeller pharmaceutical industry will go down the drain as anyone can grow marijuana in their backyard. People will no longer need to buy the real dangerous drugs you see on tv commerciasl. Wake up people, to Nate "not so great" Marquartdt do some real research before opening your mouth…dumb jock..


text:
Priscilla Cecilia (née Moore), Countess Annesley
1 portrait on display in Room 28 at the National Portrait Gallery
© National Portrait Gallery, London
Priscilla Cecilia (née Moore), Countess Annesley
by Alexander Bassano
albumen cabinet card, circa 1891
5 3/4in. x 4 1/8in. (146 mm x 102 mm)
Purchased, 1976
Photographs Collection
NPG x3820
Click on the links below to find out more:
Sitterback to top
- Priscilla Cecilia (née Moore), Countess Annesley (1870-1941), Second wife of 5th Earl of Annesley; daughter of William Armitage Moore. Sitter in 48 portraits.
Artistback to top
- Alexander Bassano (1829-1913), Photographer. Artist associated with 2797 portraits, Sitter in 4 portraits.
Linked displays and exhibitionsback to top
- Alexander Bassano: Victorian Photographer (From 25 March 2013)


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text:
A Dust Storm Along the Iranain Coast
May 17, 2013
A dust storm blew along the Iranian coast over the Gulf of Oman on June 17, 2009. The Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Aqua satellite captured this photo-like image the same day. The dust appears as a gray-beige plume along the coast, and the dust appears thickest along the plume's western edge. Source points for the storm are not obvious in this image, so the storm's origins are unclear. Semi-desert covers much of Iran, and the country has some sizeable deserts, such as Dasht-e Lut, part of which appears along the top edge of this image. If not in Iran, the dust may have originated on the Arabian Peninsula, perhaps in the United Arab Emirates (UAE) or points farther west. Credit: NASA image courtesy MODIS Rapid Response Team, Goddard Space Flight Center. Caption by Michon Scott.
Topics: Disaster Accident, Weather, Physical geography, Spacecraft, Meteorology, Dasht-e Lut, Dust storm, Dust, Moderate-Resolution Imaging Spectroradiometer, Aqua, Storm


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Scientists have discovered 100 million-year-old regions in the DNA of several plant species which could hold secrets about how specific genes are turned 'on' or 'off'.
The findings, which are hoped will accelerate the pace of research into crop science and food security, are detailed by University of Warwick researchers in the journal The Plant Cell.
By running a computational analysis of the genomes of the papaya, poplar, Arabidopsis and grape species, scientists have uncovered hundreds of conserved non-coding sequences which are found in the DNA of all four species.
These non-coding sequences are not genes, but are located in the promoters upstream of genes and are around 100 DNA base pairs in length.
As the four species have evolved separately for around 100 million years, the fact that these regions have been conserved suggests they play an important role in the plants' development and functioning.
The team at the University of Warwick believe these regions are involved in controlling the expression of the genes they are upstream of - in other words determining whether the genes are turned 'on' or 'off' according to the environmental conditions or developmental stage of the plant.
For example, some genes will be required for defence against pathogens, or others will be required for germination.
Dr Sascha Ott of the Warwick Systems Biology Centre said: "We know that certain genes are conserved between species but we also see that sequences outside of genes are conserved.
"The regions outside genes that we have discovered have been kept for millions and millions of years across four species.
"There must be a reason for this if something has been around for so long it is probably useful in some way.
"We believe it may be because these regions have a very important role to play in how the plant develops and functions.
"It is likely that they are involved in controlling gene expression a vital area fo
|Contact: Anna Blackaby
University of Warwick


text:
by Ben UFO
- Record Label: Fabric
- Release Date: Feb 12, 2013
- Critic Score
- Most active
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Jan 23, 2013Thanks to his savvy techniques and careful placement, his penchant for the far-out fringes of dance music doesn't seem weird at all, but delightfully intriguing.
Jan 23, 2013Rhythmically, Ben UFO is giddy, ebullient even. Which is why, even at his most corrosive, he is not just a very smart "crate-digger," but also a phenomenal party starter.
Jan 23, 2013At the moment, the diversity on display here feels like something to be treasured rather than wished into oblivion.
Jan 23, 2013Thomson's manifesto is articulate, incisive and practically book-length.
Jan 23, 2013while other young UK-based electronic experimentalists like Floating Points make it onto the mix, Thomson's heavy label love is a reminder that he's constantly one step ahead of the game.
Jan 23, 2013Garage, house and techno are twisted into strange new forms over the 70-odd minutes that UFO holds us enthralled for.
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text:
Hoya Announces Full-Year Financial Results Under IFRS
7741) today announced financial results under designated International
Financial Reporting Standards (IFRS) for full-year ended
Revenues from continuing operations grew 2.7% over the previous fiscal year,
Profit for the year from all operations was up 43.5% to
million yen
to the Western Digital Corporation in USA in the first quarter of this fiscal
year and
included in profit from discontinued operations.
Basic earnings per share were
last year. Diluted earnings per share were
in the last year.
"Optics business did well this year despite temporary shutdown of the
production lines due to rolling blackout after the Tohoku Great Earthquakes
in March and thanks to an increasing demand for digital cameras," said
impacts of the disaster on our company, but except digital camera business
that has difficulties in procurement of parts, our business will return
toward normal by the end of May."
HOYA also announced year-end dividends forecast of
common stock. The annual dividends, including the interim dividends of
per share, will amount to
of directors meeting in the end of May.
The full financial reports under IFRS are available in "Financial
Statement" page in HOYA website Investor Relations section at:
*The company's financial results are being prepared and reported in
accordance with IFRSs from this fiscal year.
*Results are preliminary and unaudited.
*The yen amounts shown therein are rounded to the nearest million.
About Hoya Corporation
Hoya Corporation is a global technology company based in
and the leading supplier of innovative and indispensable high-tech and
healthcare products based upon its advanced optics technologies. Hoya is
active in four fields of business: The Healthcare provides eyeglasses and
operates retail shops for contact lenses. The Medical provides endoscopic
system and intraocular lenses for cataract surgery. The Electronics makes
mask blanks and photomasks for the semiconductor devices and LCD panels as
well as glass memory disks for HDDs. The Imaging produces optical lenses,
SLR/compact digital cameras, lens modules and microlenses. Hoya now has over
100 subsidiaries and affiliates, and employs over 36,500 people worldwide.
SOURCE Hoya Corporation


text:
NME.COM artist profile on Skindred including news, reviews, videos, photos, gigs, tickets and more.
Skindred Tickets
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Skindred, Amy MacDonald, Kids In Glass Houses added to Hard Rock Calling – ticket details
Guillemots, Christina Perri and Black Stone Cherry will also play the Hyde Park festival
- Apr 17, 2012
Skindred announce April 2012 UK tour
- Nov 3, 2011
Watch Skindred's new 'Warning' video on NME.COM
- Apr 4, 2011


text:
Staff Reporter
PATHANAMTHITTA: Varghese Kurien, architect of Operation Flood, has been selected for this year's Mar Thoma Church Award.
In a statement issued here on Tuesday, Fr. K.S. Mathew, church secretary, said that the award had been conferred on Dr. Kurien in recognition of his rich contributions in the field of dairy development.
Dr. Joseph Mar Thoma, Metropolitan of Mar Thoma Church, will present the award to Dr. Kurien at a function to be held at the Church Council Chamber at S.C. Seminary in Thiruvalla on Saturday.
Dr. Philipose Mar Chrysostum, senior Metropolitan of the church, will inaugurate the meeting.
The award, comprising a purse of Rs.1 lakh and a citation, was instituted in the name of A.V. Jones alias Melpadom Attumalil Georgekutty who was known for his interest in promoting scientific and technical studies, said Fr. Mathew.


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An investigation is underway on Maui where crews recovered the body of a woman whose car fell off a cliff in Kahakuloa.
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On April 12, 2012, the California Supreme Court issued its long-awaited decision in the Brinker case, ruling on several key questions regarding an employer's obligation to provide meal and rest breaks to its non-exempt employees. Wilson Sonsini Goodrich & Rosati filed a brief on behalf of amicus curiae TechNet in support of Brinker Restaurant Corporation in the case. The highly anticipated ruling clarified that employers are not required to force employees to take meal and rest breaks in order to comply with the law. The court's holding will help employers develop compliance solutions for their particular industries.
Summary of the Court's Decision
1.When Has an Employer "Provided" a Meal Break?
Under the California Labor Code, an employer must "provide" a meal break to employees at certain times during their shifts. The Brinker case clarifies what an employer is required to do, and, just as important, what it is not required to do, in order to satisfy this requirement.
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DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
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Best Blu-ray Deals
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Price drops
Bruce Banner, a genetics researcher with a tragic past, suffers an accident that causes him to transform into a raging green monster when he gets angry.
For more about Hulk and the Hulk Blu-ray release, see Hulk Blu-ray Review published by Martin Liebman on September 30, 2008 where this Blu-ray release scored 3.5 out of 5.
Director: Ang Lee
Writers: James Schamus, Michael France, John Turman
Starring: Eric Bana, Jennifer Connelly, Sam Elliott, Josh Lucas, Nick Nolte, Stan Lee
» See full cast & crew
Hulk Blu-ray Review
He's so mean his skin is green, so very very green!
Reviewed by Martin Liebman, September 30, 2008
We're going to have to watch that temper of yours.
Fans of the Hulk are in for a Blu-ray overload, with this Ang Lee-directed release already on the shelves at the time of this review, and the new film, The Incredible Hulk, due to hit the streets in about three weeks. Why we've been blessed with two Hulk movies at the local cineplex in five years, and now on Blu-ray within a month of one another, is a matter that has generated much discussion and it just seems redundant to go into any of that dialogue here. Certainly, a great number of films have enjoyed repeat performances, but in most instances we have not seen remakes, or re-imaginings of the story, spaced so closely together. The Thing from Another World, Invasion of the Body Snatchers, and War of the Worlds, all films from the 1950s, each have had their updated versions released in the past few decades, and a remake of The Day the Earth Stood Still will soon rotate into cellphone-infested local theaters. Certainly, some remakes and re-imaginings unequivocally succeed (The Thing), others fail miserably (The Omen), and yet others still fall somewhere in the middle (Dawn of the Dead). Still, most audiences are more than eager to embrace films featuring stories that have been taken out of the proverbial mothballs and updated with plenty of pomp, circumstance, and, in many cases, an influx of computer-generated effects (all of which begs the question of whether we will ever see a remake of Plan 9 From Outer Space, or possibly an entire series of Plan films that answers the perennial conundrum -- what were the first eight plans to originate beyond our terrestrial confines?). Nevertheless, here we have two films, replete with the same primary characters, released within a mere five years of one another, but with no other cinematic connection. The two Hulk films, both big budget products of 21st century cinema, offer a rare opportunity to compare and contrast two closely-related films that nevertheless find themselves far apart one from the other in a myriad of areas. Here, however, we consider Ang Lee's 2003 Hulk, a film that barely missed recouping its $137,000,000 budget domestically. With a few minor exceptions, this release of Hulk is nothing short of technically stunning.
Scientist Bruce Banner (Eric Bana, Troy) and his associate Betty Ross (Jennifer Connelly, Dark City) are on the verge of a scientific breakthrough that has caught the interest of the military, specifically Major Talbot (Josh Lucas, Glory Road). When the genetic abnormalities passed onto Bruce by his father (Nick Nolte, The Spiderwick Chronicles), who experimented in the field of improved human DNA, are brought to shocking life when Bruce becomes subjected to a large dose of gamma radiation, his life becomes quite a bit greener. Whenever his temper flares, his chaotic cellular structure transforms him into a larger-than-life, menacing green creature with incredible strength and agility. Deemed a threat to society at large, Banner and his alter ego, The Hulk, are tracked down by Betty's father, General Ross (Sam Elliott, We Were Soliders), resulting in a series of devastating encounters between beast and military hardware.
Hulk has the feel of a comic book practically come to life, off the page and onto the big screen, evident from the opening credits forward. The film has a unique visual flair thanks to some intuitive, if not a bit gimmicky, direction from Ang Lee. Hulk's opening credit sequence is reminiscent of, but not wholly similar to, David Fincher's Panic Room, a film released a year prior. The credits are sometimes worked into the frame rather than simply appearing on-screen in a conventional manner we've seen thousands of times before. They are effected by the visuals; for example, a credit becomes hazy and slightly distorted as it is seen through a clear beaker, or the credit may be tilted at an angle, mimicking the direction of the camera. Later, the film's comic book scheme becomes plainly obvious as frames overlap one another or two or more individual windows appear on screen, mimicking a typical page from a comic book and recalling various scenes in Joel Schumacher's Phone Booth, released less than two months prior to Hulk. Viewers will note odd dissolves and frame movements all around the screen. Frames zoom in and out, adding to the surreal experience. It's experimental at best, and works rather well given the tone of the film, but this style is not something that would translate well to every comic book-based film in the future. Director Ang Lee also revels in extreme close-ups in an attempt to emphasize the emotion in a character's eyes or vocal inflection. No doubt about it, Hulk offers a unique slice of cinematic innovation.
The most obvious weakness of Hulk is in its pacing. Slow to develop and featuring plenty of exposition, the first three-quarters of the film generally drag. Fortunately, the film's emotional payoff is worth the wait. Hulk features a fine denouement, one that takes on a live theater-style look and feel. Nolte offers an incredibly powerful and effective performance near film's end, and Bana's primal reaction is equally captivating. It is a raw, wonderful scene that makes the movie and gives it a desperately needed dramatic flair after a mostly tedious two hours of exposition, semi-entertaining-at-best action, and various other minor flaws. Nolte, not only in the aforementioned climactic scene, but throughout, lends some heft and credibility to a project otherwise full of mediocre performances, including that of the otherwise reliable Sam Elliott. The Hulk effects aren't perfect, as the creature often appears a bit fake, pastel, and cartoonish, but it fits in well with the comic-book-come-alive look of the film. A more serious, menacing Hulk would not have worked as well in the context of the thematic and visual flair Ang Lee runs with throughout the picture. In the film's defense, one of the later action sequences in the desert between the Hulk and a number of tanks is well-done and enjoyable, with Lee (in conjunction with the effects team) capturing some surreal footage that drives home the impressive power of the Hulk. However, the later action sequences become dull and tedious as the film crawls towards its worthwhile climax as a helicopter attack sequence features reference sonic material on Blu-ray, but it becomes repetitious and, unfortunately, dull.
Hulk Blu-ray, Video Quality
Hulk bursts onto Blu-ray with a stunning 1080p, 1.85:1-framed transfer. Please note that the packaging erroneously reports the film's aspect ratio as 2.35:1. Glossy and bright, nearly every frame features an abundance of bright colors that translate very well to Blu-ray. Close-frame detail is superb throughout the movie. Human faces reveal every pore and line; Nick Nolte's and Sam Elliott's thick facial hair stand out clearly and distinctly in every frame. Viewers will also be privy to every splotch of ink and ridge on paper or the textures of a straw hat worn by a character early in the film. The film is colorful without being overblown. No one color is emphasized over any other, which comes as somewhat of a surprise. In this kind of film, one might expect green to be prominent in every frame, but it's not. In fact, the color is not to be seen in abundance at all in many sequences. Ang Lee instead chose to move away from this distinctive look, one employed by the filmmakers of Daredevil, for example, who chose to add many red highlights to the film. Depth is fine and the image often exhibits that desired "popping" effect, the result of crisp imagery, solid use of color, and excellent detail and clarity. Black levels are true and deep, with a good deal of shadow detail. Some of the later scenes in the film in the abandoned military housing area look pale and slightly washed out, likely a result of the bright desert sky and nearly monochromatic desert floor. Detail remains strong nevertheless. The cracks in the desert floor, the abandoned buildings, and various, aged objects scattered outside have a realistic look about them. The print does exhibits the occasional black speckle. Hulk is another fine transfer from Universal.
Hulk Blu-ray, Audio Quality
Hulk features a wonderful, high quality, loud, and aggressive DTS-HD MA 5.1 lossless soundtrack sure to please audiences with its attention to the finer nuances of the experience. An outdoor dialogue scene between Banner and Betty Ross in chapter 6 offers a very realistic environment with birds chirping all around and additional ambient noises working in harmony to make for a very good low key, yet impressive, sequence. The soundstage is immersive when need be, reserved when called for, and each scene is audibly impressive. Bass is sometimes subtle, sometimes powerful, but always clean and precise in its power. Dialogue reproduction is excellent. Nick Nolte's scruffy voice shines as his lines flow from the center channel. The soundtrack is fairly reserved -- until the Hulk finally breaks free form the inner confines of friendly scientist Bruce Banner. The track explodes in a symphony of Earth- and ear-shattering effects, as the soundstage becomes immersed in heart pounding thuds, crashes, and bangs in chapter 11. Not only does the subwoofer sound out every step the Hulk takes, but the surrounds come alive with a myriad of activity that all seamlessly integrates with the visuals we see on display. Every scene featuring the Hulk as he destroys property is an amazing sonic feat. Chapter 15 features plenty of broken structures, shattering glass, machine gun fire, and a car alarm, all making for another impressive sequence. As expected, the film's later action sequences in the desert are reference-quality, audibly. The Hulk never misses a beat thanks to this fine lossless soundtrack.
Hulk Blu-ray, Special Features and Extras
This Blu-ray presents Hulk with a nice selection of supplemental materials. A feature commentary track with director Ang Lee highlights the package. Lee delves straight into his ideas for the film, offering viewers further insight into his unique vision. He discusses the film's special effects, character development and themes, shooting locations, logistics, and other films that inspired and aided him in the making of Hulk. Despite a series of brief gaps in the track, Lee remains interesting and enthusiastic and his commentary should please fans. Like most other Universal discs to date, Hulk is U-Control enabled. As always, a picture-in-picture window will appear over the film, providing various areas of insight into the world of Hulk. The window appears sporadically, but users may jump directly to each segment through the U-Control tab in the main menu.
The Making of 'Hulk' (480p, 23:43) is a four-part feature that delves into the strengths the cast and crew brought to the film, a look at some of the stunts and physical effects scattered throughout the film, the contributions of Industrial Light and Magic in creating the film's impressive special effects, and Danny Elfman's (Beetlejuice) score. Evolution of the Hulk (480p, 16:17) looks at the history of this popular character. The piece begins by examining the character's origin in depression-era America, glossing over the history of Marvel comics, and further examining the development of the character in the comics, the animated series, the CBS television series, "The Incredible Hulk," which featured famed bodybuilder Lou Ferrigno as the Hulk and Bill Bixby as Bruce Banner, and finally, this 2003 film adaptation. The Incredible Ang Lee (480p, 14:28) examines the contributions of the director not only behind the camera, but his work in numerous other aspects of the filmmaking process to make Hulk as successful as can be. The Dog Fight Scene (480p, 10:09) takes viewers behind-the-scenes of the process in making this crucial scene. Finally, The Unique Style of Editing 'Hulk' (480p, 5:34) takes a closer look at the editing process to make Hulk as cohesive, well-paced, and exciting as possible, while creating for the film a unique look with differing transitions and split screens.
Hulk Blu-ray, Overall Score and Recommendation
Hulk is a film filled with wonderful potential. Featuring fantastic visuals, a unique style of filmmaking, and a classic climax that is acted to perfection, the film ought to be a surefire winner. Unfortunately, a needlessly complex plot, a longer-than-necessary runtime that is further bogged down by slow pacing, and decent action sequences that become repetitious though visually impressive, Hulk is more of a letdown than it ought to be. Still, the film is worth watching for all the things it does right; just don't expect to be completely enthralled for every second. Universal Picture's Blu-ray release of Hulk is spectacular. The disc features excellent picture and sound quality that teeters on reference material, and offers fans a nice spread of extra materials. For fans, a purchase is a no-brainer; others may want to rent this film first.
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• Today on Blu-ray - September 16th - September 16, 2008
The biggest releases this week actually come for one of the smallest major studios. After a nasty divorce with Disney, Harvey and Bob Weinstein left the Miramax name behind and formed The Weinstein Company. While their film library may be small - they only retained ...
• Hulk Coming to Blu-ray - August 1, 2008
Universal Studios Home Entertainment has announced that they will bring Ang Lee's 'Hulk' to Blu-ray on September 16th. The film, which made its high definition debut on the now defunct HD DVD format, will come on a BD-25 utilizing 1080p video and a 5.1 DTS-HD Master ...
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Monday, 25 May, 2015
24/7 internet radio station playing Industrial music from the 80s ...
Score: 10.62 Category: Music\Sound Files
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Photographs of London, 1970-83, taken by Peter Marshall concentrating on ...
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Portfolio of an Industrial designer/consultant.
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Different aspects of the urban and Industrial landscape.
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A photoblog with a focus on architecture and Industrial decay.
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Contains biography, photos, and show dates of the Industrial rock ...
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Electronic-punk Industrial band's official site.
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Book to travel in July, August or October 2015 on Belmond Hirondelle or Belmond Napoleon and your companion will travel half price.
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This is a Green Stacks event.
Come to the library, check out the show, get a library card, and enjoy some books!
Meet a friend at the library for free activities and fun.
There is something fun going on at your library every week during the time of the Summer Reading Program.
Upcoming Events
- Crafty Friday
- Friday, May 29, 2015Mission, Mission Children's Area
- Japanese Windsock with GoGo Craft
- Friday, May 29, 2015Chinatown, Chinatown Meeting Room
- Knitting Circle
- Saturday, May 30, 2015Sunset, Sunset Children's Area
Upcoming Classes
- Family Craft Night
- Wednesday, May 27, 2015Bayview, Bayview Meeting Room
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- Tuesday, June 2, 2015Excelsior, Excelsior Meeting Room
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From the Publisher'This volume represents a synthesis of human service practice and the academic field of sociology. The primary audience for this book is upper-level undergraduate sociology students, but the material has been used in a graduate course on sociological practice. Professionals practicing in the human service field, especially those without backgrounds in sociology who are trying to align their practices with the new client- and family-centered partnership models may find this book useful.'
Administration and Policy in Mental Health, January 2001