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Examination of postmortem fluids and tissues for the presence of methylecgonidine, ecgonidine, cocaine, and benzoylecgonine using solid-phase extraction and gas chromatography-mass spectrometry.
On the basis of this information, it would be reasonable to expect individuals smoking crack COC to inhale significant amounts of MED. As a result, the detection of MED would be a valuable marker to aid in identifying smoking as a route of administration and in estimating COC concentrations at the time of death.
There are additional considerations in the analysis of MED. Once in the body, the concentration of MED might be expected to be lower because of conversion to ecgonidine (ED). The hydrolysis of MED to ED has been reported, and ED has been detected in human urine (7, 8). Urine specimens that had tested positive for benzoylecgonine (BZ) in the military drug-testing program were tested for MED and ED. In 22 of the 23 specimens tested, ED was detected, and the concentrations were at least an order of magnitude greater than those of MED. These results suggest the value of quantifying both MED and ED to identify COC smoking as the route of administration.
Although MED and/or ED have been examined in various tissues and fluids (2, 3, 7-13), MED has not been examined in liver and brain tissue, and ED has not been examined in liver, brain, and blood specimens. We examined the available specimens from 15 postmortem cases for the presence of MED, ED, COC, and BZ.
Materials and Methods
N-desmethyl-N-[[sup.2.H.sub.3]]methylcocaine ([d.sub.3] COC), BZ, N-des-methyl-N-[[sup.2.H.sub.3]]methylbenzoylecgonine ([d.sub.3]-BZ), N-desmethyl-N-[[sup.2.H.sub.3]]methylecgonine ([d.sub.3]-EC), ecgonine, MED (anhydroecgonine methyl ester), and ED (anhydroecgonine) were purchased from Radian International. COC (free base) was purchased from Sigma Chemical, and dimethylformamide (DMF), DMF dipropyl acetal (DMF-DPA), and DMF dimethyl acetal were purchased form Aldrich Chemical. Solid-phase extraction (SPE) columns containing silica-based [C.sub.8] and S[O.sub.3]H (200 mg) and a glass extraction chamber were purchased from United Chemical Technologies. Reacti-vials, bis(trimethylsilyl)trifluoroacetamide (BSTFA), and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA) containing 1% tert-butyldimethylchlorosilane (TBDMCS) were purchased from Pierce. All solvents and reagents were analytical or HPLC grade. Acetone was dried over molecular sieves (3A, 8-12 mesh) for at least 24 h.
Specimens from 15 postmortem cases were obtained from the Postmortem/ Human Performance Laboratory, Division of Forensic Toxicology, Armed Forces Medical Examiners' Office, Armed Forces Institute of Pathology. The research protocol was approved by the Armed Forces Institute of Pathology Institutional Review Board. Specimens reported to be positive for COC/BZ had been screened positive by immunoassay, confirmed positive by gas chromatography-mass spectrometry (GC-MS), and stored frozen at -18[degrees]C for 6 months after testing was completed. Before use in this study, specimen identity was removed in preparation for disposal. Complete information concerning the specific source for each fluid and tissue was not available for any case. A significant impact on results was unlikely for the liver specimens because drug distribution in liver tissue would be expected to be uniform as a result of normal high hepatic profusion and metabolic activity. Brain tissue may have been obtained from various portions of the brain because there is no standardized procedure concerning the source of brain tissue. This most likely did not have a significant impact on our results, based on the reported uniform distribution of COC in postmortem brain tissue (14). Urine was obtained directly from the bladder. In a few cases, blood specimens were obtained directly from the heart or from an intravenous catheter.
The Hewlett-Packard GC-MS system consisted of an HP 5890 Series II Plus gas chromatograph and a Model 5972 quadrupole mass-selective detector. An HP 18593B auto-injector was used to inject the samples into the GC-MS instrument.
SYNTHESIS OF METHYL N-DESMETHYL-N-[[sup.2.H.sub.3]]METHYLECGONIDINE ([d.sub.3]-MED)
The starting compound, N-desmethyl-N-[[sup.2.H.sub.3]]methylecgonidine ([d.sub.3]-ED) was prepared from 200 [micro]g of [d.sub.3] EC by the procedure published previously (7). DMF dimethyl acetal (50 [micro]L) was added to the compound in a Reactivial. The vial was tightly capped, vortex-mixed, and heated at 50[degrees]C for 5 h. The solution was cooled to room temperature. The [d.sub.3]-MED, without further purification, was quantitatively transferred to a 50-mL volumetric flask and diluted to the mark with acetonitrile. When compared against a known amount of nondeuterated MED, the concentration of [d.sub.3]-MED was found to be 2.08 mg/L. On the basis of the molar concentration compared to the starting material, [d.sub.3]-ED, the yield was 84%.
Solutions of COC, [d.sub.3] COC, MED, and [d.sub.3]-MED at appropriate concentrations were prepared in acetonitrile. Hydroxy solvents were not used to avoid hydrolysis of methyl esters. Solutions of BZ, [d.sub.3]-BZ, ED, and [d.sub.3]-ED were prepared in methanol.
Liver and brain tissue samples. The flowchart for the extraction is shown in Fig. 1. For each specimen and control, 1 g of tissue (negative tissue for control) was weighed into flat-bottomed plastic tubes and stored frozen. Controls were prepared at concentrations of 100, 50, and 20 ng/g of tissue by adding COC (100 [micro]L of 1.0, 0.5, or 0.2 mg/L), BZ (100 [micro]L of 1.0, 0.5, or 0.2 mg/L), MED (100 [micro]L of 1.0, 0.5, or 0.2 mg/L), and ED (100 [micro]L of 1.0, 0.5, or 0.2 mg/L) into three empty glass centrifuge tubes. Internal standards (100 [micro]L of 0.5 mg/L [d.sub.3] COC, 100 [micro]L of 0.5 mg/L [d.sub.3]-BZ, 50 [micro]L of 0.68 mg/L [d.sub.3]-MED, and 100 [micro]L of 0.5 mg/L [d.sub.3]-ED) were added to the control tubes and to empty glass centrifuge tubes that were later used for specimen analysis.
Freshly prepared NaF (200 [micro]L; 10 g/L) was added to the tissues in the plastic tubes. The tissues were thawed, homogenized with 1 mL of 0.1 mol/L phosphate buffer (pH 6.0), and poured into the corresponding glass tubes containing drugs and internal standards for controls and internal standards only for specimens. Two milliliters of 0.1 mol/L phosphate buffer (pH 6.0) was then added to the residual tissue and homogenized again. The resulting homogenate was combined with the initial homogenate.
After homogenization, the tubes were capped and placed in an ice bath. The homogenates were vortex-mixed for 10-15 s and centrifuged for 60 min at 3834g at 7-10[degrees]C. A set of SPE columns was placed in the extraction chamber and conditioned with 3 mL each of methanol, water, and 0.1 mol/L phosphate buffer (pH 6.0), in that sequence, under slightly reduced pressure.
A set of glass centrifuge tubes was placed in the chamber to collect the next elution fraction (containing ED). The supernatants from the tissue homogenates were poured onto the columns and allowed to elute by gravity or under slightly reduced pressure. Deionized water (1 mL) was added to the columns, and that fraction was also collected. The tubes from the chamber were then removed and set aside for extraction of ED (Fig. 1). The SPE columns were washed with 2 mL of deionized water, 3 mL of 0.1 mol/L HCl, and 3 mL of isopropanol, and then dried for 5 min under reduced pressure. The MED, COC, and BZ were then eluted with 3 mL of a mixture (9:1:0.2 by volume) of dichloromethane-methanol-aqueous N[H.sub.3] (14.8 mol/L).
The solutions were evaporated to dryness under nitrogen at room temperature to minimize loss of MED. The extracts were dissolved in 50 [micro]L of dry acetone, transferred into autosampler vials, and tested for MED and COC by two separate GC-MS procedures. After the MED and COC tests, the samples were tested for BZ as the propyl derivative, using another GC-MS procedure.
To extract ED from the eluates, the pH of the solutions was adjusted to 2.0 [+ or -] 0.2 with 0.5 mol/L HCl. Methylene chloride (1 mL) was added to each tube and vortex-mixed. The solutions were centrifuged at 2177g for 3 min. The clear upper aqueous layers were then poured onto a second set of SPE columns preconditioned with 3 mL of methanol, 3 mL of deionized water, and 1 mL of 0.01 mol/L HCl. The solutions were allowed to elute by gravity flow or under slightly reduced pressure. The columns were washed with 1 mL of 0.1 mol/L HCl and 3 mL of methanol, and dried under reduced pressure for 5 min. The ED was eluted with 3 mL of a mixture (4:6:0.25 by volume) of methanol-isopropanol-aqueous N[H.sub.3] (14.8 mol/L). The solutions were evaporated under nitrogen at 50[degrees]C. To remove the white residue from ED, 2 mL of dry acetone was added. The solutions were vortex-mixed and centrifuged. The acetone solutions were separated and evaporated to dryness. The liver specimens were tested for ED as the tert-butyldimethylsilyl derivative by a GC-MS method, and the brain specimens were tested for ED as the trimethylsilyl derivative by GC-MS.
Urine and blood samples. An initial 3-mL aliquot of each urine specimen was prepared as published previously (7). The procedure used for preparing blood specimens was the same as for the liver and brain tissues with the following exceptions. The initial 1-mL aliquots of blood were diluted with 4 mL of 0.1 mol/L phosphate buffer (pH 6.0). No methylene chloride wash was used in preparing the ED-containing fractions for the SPE steps.
Propylation of BZ at the GC injection port for specimen analysis. After COC and MED analysis in acetone solution, DMF-DPA (20 [micro]L) was added to the autosampler vials. The contents were mixed, and the vials were recapped. Analysis was performed for propyl-BZ as reported previously (7).
Silylation of ED by MTBSTFA for specimen analysis. The extracts from liver and urine containing ED were dissolved in MTBSTFA containing 1% TBDMCS and prepared as described previously (7).
Silylation of ED by BSTFA for specimen analysis. The extracts from brain and blood containing ED were dissolved in 50 [micro]L of BSTFA and heated in closed tubes at 70[degrees]C for 15 min. The samples were centrifuged immediately at 7-10[degrees]C for 2-3 min at 1700g and transferred to autosampler vials for GC-MS analysis.
Samples were introduced in 1- to 4-[micro]L volumes using an autoinjector. The GC analysis was performed using a DB-5MS capillary column [5:95 phenyl-methylsiloxane; 15 m x 0.25 mm (i.d.); J & W Scientific] or a ZB-5 [5% phenyl polysiloxane; 15 m x 0.25 mm (i.d.); Phenomenex] at 10 psi constant pressure helium flow. The mass-selective detector was operated in the electron ionization mode at 70 eV with a source temperature of 200-250[degrees]C. The electron multiplier voltage of the detector was set at 200-700 V above autotune, and the dwell time for each ion monitored was 50 ms.
GC-MS conditions for MED. The analysis was performed at injector and transfer line temperatures of 140 and 280[degrees]C, respectively. The oven temperature started at 90[degrees]C (held for 1 min) and increased to 140[degrees]C at 20[degrees]C/min (held for 2 min). The GC was started in splitless mode, and injector port purge was turned on after 0.3 min. The monitored ions were m/z 181, 166, and 152 for MED and m/z 184 and 155 for the [d.sub.33]-MED. Ions m/z 152 and 155 were used for quantification. Because COC, BZ, and MED were extracted together, injector temperatures were kept [less than or equal to] 140[degrees]C to avoid possible formation of MED from any COC present in the sample. After each injection, 2-3 [micro]L of acetone was injected as a solvent blank.
GC-MS conditions for COC. The analysis was performed at injector and transfer line temperatures of 280 and 270[degrees]C, respectively. The oven temperature started at 170[degrees]C (held for 0.5 min) and increased to 270[degrees]C at 30[degrees]C/min (held for 2.7 min). The GC was started in splitless mode, and injector port purge was turned on after 0.3 min. The monitored ions were m/z 303, 272, and 182 for COC and m/z 306 and 185 for the [d.sub.3] COC. Ions m/z 303 and 306 were used for quantification. After each injection, 3 [micro]L of acetone was injected as a solvent blank.
GC-MS conditions for propyl BZ. The analysis was performed at injector and transfer line temperatures of 280 and 270[degrees]C, respectively. The oven temperature started at 170[degrees]C (held for 0.5 min) and increased to 270[degrees]C at 30[degrees]C/min (held for 2.7 min). The GC was started in splitless mode, and injector port purge was turned on after 0.3 min. The monitored ions were m/z 331, 272, and 210 for BZ and m/z 334 and 213 for [d.sub.3]-BZ. Ions m/z 331 and 334 were used for quantification. After each injection, 3 [micro]L of MTBSTFA containing 1% TBDMCS was injected as a solvent blank.
GC-MS conditions for tert-butyldimethylsilyl ED. The analysis was performed at injector and transfer line temperatures of 250 and 270[degrees]C, respectively. The oven temperature started at 135[degrees]C (held for 0.5 min), increased to 175[degrees]C at 10[degrees]C/min (held for 0.5 min), and increased to 275[degrees]C at 30[degrees]C/min (held for 1 min). The GC was started in splitless mode, and injector port purge was turned on after 0.2 min. The monitored ions were m/z 281, 252, and 224 for ED and m/z 284 and 227 for the [d.sub.3]-ED. Ions m/z 224 and 227 were used for quantification. After each injection, 3 [micro]L of MTBSTFA containing 1% TBDMCS was injected as a solvent blank.
GC-MS conditions for trimethylsilyl ED. The analysis was performed at injector and transfer line temperatures of 200 and 220[degrees]C, respectively. The oven temperature started at 111[degrees]C (held for 1 min) and increased to 210[degrees]C at 25[degrees]C/min (held for 2 min). The GC was started in splitless mode, and injector port purge was turned on after 0.2 min. The monitored ions were m/z 239, 224, and 210 for ED and m/z 242 and 213 for the [d.sub.3]-ED. Ions m/z 210 and 213 were used for quantification. After each injection, 3 [micro]L of BSTFA was injected as a solvent blank.
The statistical analysis of the data sets was performed using ANOVA. To be a significant difference, both sets had to show a difference at P <0.05.
Results and Discussion
MED is a pyrolytic product of COC. Both MED and ED are also produced as artifacts from COC or COC metabolites during GC-MS analysis (7). Therefore, suitable analytical conditions are necessary to test MED and ED in body fluids and tissues. In the extraction, ED was separated from other drugs by selective adsorption on the SPE columns ([C.sub.8] and S[O.sub.3]H). At pH 6.0 [+ or -] 0.5, most of the COC, BZ, and MED (>90%) were retained on the column, whereas ED, which did not adsorb, passed through the column and was collected. ED was then extracted from the solution by adjusting the pH to 2-3 and allowing it to pass through a second column. At this pH, ED was more lipophilic and suitable for column adsorption. The compound was then eluted with a mixture of polar solvents [methanol-isopropanol-ammonia (4:6:0.25 by volume)]. To elute MED, COC, and BZ from the first column, dichloromethane-methanol-ammonia (9:1:0.2 by volume) was preferred over the generally used dichlorobutane-isopropanol-ammonia (8:2:0.2 by volume) because MED is volatile and easily lost during evaporation of the higher boiling isopropanol.
Separation of ED from COC and COC metabolites minimized the formation of artifact ED. MED in the extract of COC and BZ was analyzed separately at a GC injection port temperature of [less than or equal to] 140[degrees]C. Higher temperatures were avoided to minimize formation of artifact MED. To ensure that artifacts were not formed during analysis, a control containing COC, BZ, EC, and MEC at 1, 5, 5, and 5 mg/L, respectively, was tested. No ED or MED was detected under the extraction and GC-MS conditions described. COC was also injected separately before derivatization of BZ because the alkylating agents contained a small amount of methylating agent as impurity. In our experiment, DMF-DPA, DMF-diisopropylamide, or DMF-diethylamide with only BZ produced a small amount of COC as byproduct (<1%). Although MED and COC were injected under two different conditions (injection temperatures 140 and 280[degrees]C, respectively), the samples could be analyzed in one injection batch by use of an autoinjector with two GC-MS settings. ED extracted from blood and brain and tested as the tert-butyldimethylsilyl derivative showed chromatographic background. Analyzing the compound as the trimethylsilyl derivative minimized the background.
The linearity, correlation coefficient squared ([r.sup.2]), limit of quantification (LOQ), and extraction efficiency are summarized in Table 1. In the range of linearity, all compounds showed ion ratios within [+ or -] 20% of the mean values. At least eight concentrations were used in the range of linearity. Only one sample was tested at each concentration. Good correlation [r.sup.2] was observed in the linear range mentioned, where acceptable values were defined as [greater than or equal to] 0.9900. Signal-to-noise ratios in all analyses were >4:1. In this study, LOQ was defined as the concentration at which one of the two ion ratios was outside [+ or -] 20% but within [+ or -] 30% and the concentration was within [+ or -] 20% of expected value. Quantification ions in some compounds showed better chromatographic background, allowing a LOQ below the limit of linearity. This observation was most likely attributable to the variability of the biological matrices among the various tissues and fluids. Specimens were analyzed in several batches, and controls at concentrations of 0, 20, 50, and 100 [micro]L were used in each batch analysis to validate the results. The criteria for batch validation were the same as those used for linearity studies.
Case histories for the specimens were extremely limited, although preliminary causes of death were not attributed to drug overdose. The results from the analyses by drug are summarized in Tables 2 and 3. Fig. 2 shows chromatograms for ED extracted from blood specimen 4 (Fig. 2a) and MED extracted from brain specimen 11 (Fig. 2b), where the concentrations were 25 [micro]g/L and 22 ng/g, respectively. The ranges for MED concentrations in liver, brain, blood, and urine were 0-10 ng/g, 0-92 ng/g, 0-42 [micro]g/L, and 0-2030 [micro]g/L, respectively. The number of samples in which MED was detected was 5 of 15, 7 of 14, 3 of 11, and 10 of 13 in liver, brain, blood, and urine, respectively. Although MED was detected in 5 of 15 liver specimens, the observed concentrations did not exceed 10 ng/g in any specimen. In contrast, urine concentrations as high as 2030 [micro]g/L were observed, and 6 of the 13 urine specimens reached concentrations in excess of 100 [micro]g/L. In general, MED concentrations were much lower in brain than in urine. The range of MED concentrations in the liver specimens was slightly larger than in the brain specimens. Although examining brain for estimating COC concentrations at the time of death may have some advantage because of the free passage of COC across the blood-brain barrier, the characteristics of MED relative to the blood-brain barrier have not been established. The high number of blood samples negative for MED or with low MED concentrations may indicate that detection of MED may be difficult in blood and be of limited usefulness in the estimation of COC concentrations at the time of death. On the basis of these observations along with other concerns for the use of blood in evaluating COC use in postmortem cases (15), other tissues and/or fluids may be more useful in postmortem examinations.
ED concentrations were noticeably higher than MED in liver, blood, and urine. In liver, the median ED concentration was 655 ng/g (range, 90-3274 ng/g) compared with 0 ng/g (range, 0-10 ng/g) for MED. Similar results were observed in blood. The amount of ED was relatively low in brain, and there was no statistical difference compared with MED concentrations in brain tissue. This indicates that ED does not easily pass through the blood-brain barrier, which might be expected based on the hydrophilic nature of ED, and may also be accompanied by extensive first- or second-pass metabolism of MED in the liver and efficient excretion of ED by the body via the kidneys. This may also indicate that any MED that may enter the brain is converted to ED via enzymatic hydrolysis at a very low rate, which may parallel the observation that cocaine methyl esterase activity in brain is only 1-6% compared with liver in rats (16). Although MED was detected in only 3 of 11 blood specimens, ED was detected in all blood specimens. This suggests that MED is extensively converted to ED in the blood as well as in the liver, which is supported by the previously reported hydrolysis of MED to ED in liver homogenates (7) and the enzymatic hydrolysis observed in unpreserved sheep plasma (17).
When the ED concentrations in liver and urine were compared, 6 of 13 specimens contained more ED in liver than in urine. In 8 of 15 liver specimens, the amount of ED actually exceeded the amount of BZ. ED was detected in all 15 cases (50 of 53 total specimens), indicating that smoking was a route of COC administration. Compared with the detection of MED in 12 of 15 cases (25 of 53 total specimens), ED appears to be more easily detected than MED and may be a more useful marker than MED for determination of COC smoking in postmortem cases.
In conclusion, a review of the data reveals that ED concentrations were significantly higher than MED concentrations in liver, blood, and urine. In brain the difference was not significant. Of 53 tissue and fluid specimens collected from 15 postmortem cases, 50 specimens were positive for ED compared with only 25 specimens positive for MED. Only three brain specimens were negative for ED. The presence of ED and MED suggests that smoking was the route of COC administration in all 15 postmortem cases.
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ERIC T. SHIMOMURA, GWENDOLYN D. HODGE, and BUDDHA D. PAUL *
Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Rockville, MD 20850.
The opinions expressed herein are those of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, the Department of the Navy, the Department of the Air Force, or the Department of Defense.
[1] Nonstandard abbreviations: COC, cocaine; MED, methylecgonidine; ED, ecgonidine; BZ, benzoylecgonine; [d.sub.3]-COC, N-desmethyl-N-[[sup.2.H.sub.3]]methylcocaine; [d.sub.3]-BZ, N-desmethyl-N-[[sup.2.H.sub.3]]methylbenzoylecgonine; [d.sub.3]-EC, N-desmethyl-N-[[[sup.2.H.sub.3]]]methylecgonine; DMF, dimethylformamide; DMF-DPA, DMF dipropyl acetal; SPE, solid-phase extraction; BSTFA, bis(trimethylsilyl)trifluoroacetamide; MTBSTFA, N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide; TBDMCS, tert-butyldimethylchlorosilane; GC-MS, gas chromatography mass spectrometry; [d.sub.3]-MED, methyl N-desmethyl-N-[[sup.2.H.sub.3]]methylecgonidine; [d.sub.3]-ED, N-desmethyl-N-[[sup.2.H.sub.3]]methylecgonidine; and LOQ, limit of quantification.
* Address correspondence to this author at: Division of Forensic Toxicology, AFIP Annex, 1413 Research Blvd., Rockville, MD 20850. Fax 301-319-0628; e-mail email@example.com.
Received January 10, 2001; accepted March 12, 2001.
Table 1. Linearity, correlation coefficient squared ([r.sup.2]), LOQ, and extraction efficiency for MED, ED, COC, and BZ from postmortem specimens. Linearity, LOQ, (a) Extraction [mu] g/L [r.sup.2] [mu] g/L efficiency, % Liver MED 6-150 0.9982 5 >90 ED 20-500 0.9989 10 50-60 COC 20-500 0.9966 5 >90 BZ 20-500 0.9991 5 >90 Brain MED 20-300 0.9994 5 >90 ED 20-500 0.9971 10 50-60 COC 15-2000 0.9992 5 >90 BZ 15-2000 0.9969 5 >90 Blood MED 20-300 0.9982 5 >90 ED 20-300 0.9989 10 50-60 COC 10-500 0.9966 5 >90 BZ 10-500 0.9991 5 >90 Urine MED 2-300 0.9965 2 >90 ED 10-300 0.9979 10 50-60 COC 5-500 0.9933 5 >90 BZ 5-500 0.9996 5 >90 (a) When LOQ was below the lowest limit of linearity, one of the ion ratios was outside [+ or ] 20%, but quantification was within [+ or -] 20% of the expected value. Table 2. Drug concentrations in liver and brain from 15 postmortem specimens. (a) Liver, ng/g Specimen MED ED COC BZ 1 0 90 0 60 2 0 132 0 68 3 0 221 66 612 4 0 293 0 45 5 0 334 21 149 6 0 428 11 440 7 0 596 57 103 8 0 655 9 821 9 0 1131 21 890 10 0 2582 426 1643 11 5 1406 134 2755 12 6 1644 103 3513 13 8 1950 503 4980 14 8 2134 77 2963 15 10 3274 270 2430 Median 0 655 57 821 Range 0-10 90-3274 0-503 45-4980 Positive 5/15 15/15 12/15 15/15 Brain, ng/g Specimen MED ED COC BZ 1 0 7 0 3078 2 0 0 0 46 3 92 0 1403 474 4 0 0 0 47 5 0 48 33 61 6 0 12 37 283 7 NA (b) NA NA NA 8 0 22 8 1489 9 0 22 14 290 10 31 52 336 222 11 22 26 863 592 12 17 43 704 5153 13 14 40 546 2707 14 29 17 707 2982 15 19 34 490 574 Median 7 22 187 524 Range 0-92 0-52 0-1403 46-5153 Positive 7/14 11/14 11/14 14/14 (a) Values of 0 indicate quantification below the LOQ. (b) NA, specimen not available. Table 3. Drug concentrations in blood and urine from 15 postmortem specimens. (a) Blood, [mu] g/L Specimen MED ED COC BZ 1 0 13 0 30 2 0 36 0 60 3 NA (b) NA NA NA 4 0 25 0 32 5 NA NA NA NA 6 0 60 5 332 7 0 299 30 87 8 0 29 5 458 9 0 119 13 628 10 11 214 35 1543 11 0 314 20 1519 12 NA NA NA NA 13 42 143 12 2071 14 8 773 88 1831 15 NA NA NA NA Median 0 119 12 458 Range 0-42 13-773 0-88 30-2071 Positive 3/11 11/11 8/11 11/11 Urine, [mu] g/L Specimen MED ED COC BZ 1 0 126 37 917 2 0 468 155 2084 3 62 109 1918 1736 4 0 146 63 999 5 48 456 1229 6768 6 14 226 185 3948 7 132 307 1119 1705 8 40 296 475 14 748 9 116 1143 1208 19 740 10 NA NA NA NA 11 1299 1826 13 520 42 462 12 2030 7452 20 528 116 430 13 616 1116 28 062 39 624 14 999 2729 4214 107 868 15 NA NA NA NA Median 62 456 1208 6768 Range 0-2030 109-7452 37-28 062 917-116 430 Positive 10/13 13/13 13/13 13/13 (a) Values of 0 indicate quantification below the LOQ. (b) NA, specimen not available.
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|Shimomura, Eric T.; Hodge, Gwendolyn D.; Paul, Buddha D.
|Clinical Chemistry
|Jun 1, 2001
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Delphi's Vehicle Diagnostics system works best as a tool for parents who let their kids drive the family car, as it shows the car location and will trigger an alert if the car leaves a proscribed area.
Automotive supplier Delphi demonstrates its self-driving car platform called Drive on the streets of Las Vegas during CES 2015.
Automotive Tier 1 supplier Delphi aims to test and prove its autonomous car technology by letting it drive from San Francisco to New York City.
The Department of Transportation accelerates on the road to autonomy with a proposal to require vehicle to vehicle to vehicle communications in future cars.
Technically Incorrect: A smattering of the self-driving cars on California roads have been involved in incidents in the last six months. None of them, say their manufacturers, were the fault of the cars.
Though the Delphi NAV300 GPS navigator may look appealing with its affordable price tag and integrated Bluetooth and text-to-speech functionality, real-world tests show some pretty ugly results.
Part publicity stunt and part research, automotive equipment supplier Delphi plans to test its autonomous car technology by having it drive from San Francisco to the New York Auto Show.
Autonomous-driving tech is being put to the test in what's billed as the longest U.S. coast-to-coast journey of a self-driving car. CNET's Kara Tsuboi shows us how car equipment supplier Delphi plans to journey from San Francisco to New York, through states that currently don't allow autonomous driving.
The basic AM radio was the first car infotainment device, giving drivers entertainment and important news alerts. At Delphi's new Silicon Valley lab, the auto parts supplier displays 80 years' worth of car radio development.
At a launch event for its new Silicon Valley facility, automotive supplier Delphi demonstrated sensor and infotainment technologies.

subset: commoncrawl


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ApplianceGeneral Electric Refrigerator
Level of DifficultyReally easy
Time to do repair1- 2 hours
Age of Appliance5 - 10 years
Parts Select ,site helped me diagnose the Problem,I found the Defrost heater element Burnt out,the glass had gone black,so i replaced with the one which i ordered from Parts select,the new heater being a twin element,i had to stretch the left cable by making it loose by cutting the tie raps,which were bundeled with other wires,and brought it to right side ,berely making it without making a extenson of the kit which came with the parts.I also replaced the defrost Thermostat since i was almost there inside the panel .(I changed the Thermostat first & then i replaced the Heater,which i found burnt out ,black tube,had i replaced the Heaters first,i might have not replaced the Thermostat,as i checked with a multimeter the Thermostat was good.) It is easy to check the heaters first,then you know that is the problem,if black or no continuity with multimeter,then replace this only & u could save some money on Thermostat. I Thank Parts Select for easy instructions & saving Money. I called PC Richard /GE they said will give appointment after 6 days & charge $100/- for visit, Plus Parts extra, My Fridge is back running again,keep up the Goodwork Parts Select I will Defenately Recommend others to your site.
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Description: A little piece of organic heaven for your organically grown little one. 100% organic cotton interlock fitted crib sheet and flower print poplin crib skirt.
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Best selection and great deals on Baron Custom Accessories Shop, Tools & Trailers. Dennis Kirk carries more Baron Custom Accessories products than any other aftermarket vendor and we have them all at the lowest guaranteed prices. Not only that, but we have them all in-stock and ready to ship today. Dennis Kirk has been the leader in the powersports industry since 1969, so you can rest assured that we have your back when it comes to bringing you the best Baron Custom Accessories Shop, Tools & Trailers products. You'll enjoy our no-hassle return policy and all orders over $89 receive free shipping, so you can shop with complete confidence at Dennis Kirk!


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Ha me too! I'm a lurker of Candlepower but never even knew this whole section existed here. I carry an EagleTac T20C2 MKII on my duty belt and a Quark Mini AA when I wear a thigh holster, otherwise I just toss it in my pocket as a backup. Both have served me well.
10/2/11 at 4:55am


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text: Aimee Cohen/Woman Up! Posted 3:32 AM, July 23, 2014, by Craig Collins, Updated at 03:34am, July 23, 2014 EmailTwitterFacebookGoogleRedditPinterest × Aimee Cohen/Woman Up! Author Aimee Cohen joins Patti in studio to talk about her brand spanking new book "Woman Up! Overcoming the 7 Deadly Sins that Sabotage Your Success." http://cdn.tribtv.com/wgnam/podcasts/pattivasquez/AmyCohenPatti72214.mp3


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Kortney Ehrhart - Lafayette
i love synyster gates!!!
i want to meet you :(
my idol
see you at download 2011
sexyness! <333
I was at this concert and he did an awesome job!
synyster muittttttto foda!!!!! melhor guitarrista do mundo!
:Q___ i love you syn....more that anyone else ....more that michelle too <3 <3
syn the best guitar.........
yeah tomorrow 07/07/11 we comemorate 30years of the grace for the existence of BRIAN HANER jr
Happy Birthday Brian (: We all love you and I hope you enjoy this day as much as you can, and never forget your fans around the world, and here in Portugal, that love and support you and the band. You guys gave me the best night of my life, 23.06.2011, the amazing show you gave in Lisbon, Portugal. We sang and scream so loud that I hope you understood how much we love you and admire you. Hope to see you guys here next year! And happy 30th again buddy, wish you the best!
Happy Birthday, Syn. :) I hope to see you guys in Pittsburgh on the 16th of September. I admire you so much and hope to meet you someday!!
Happy Birthday, Syn!
Enjoy this day that is only for you (:
Lots of hugs, kisses and love from Mexico
I hope to meet you someday.
Syn Gates so fucking awesome on the guitar. Love the funny guy
:X Syn!! he is sooo sexy and obviously extremely talented! i love watching him play so sexy! its like hes in his own lil world<3
total sexiness omg i would die to chill with the hottest guitarplayer ever!!!! I LOVE YOU SYNYSTER GATES!!!!!!!! <3<3<3<3
I have to say you're one of the best guitar players ever! I know you probably never read this but you're really good on this ,so please, never stop doing this! We love you Mr. Gates! :)
omg i love you sooooooooooooooooooooooooosososososososososososososososososooo much you cant even imagine ! you are my IDOL and i want to be just like you (: <3 <3 <3 <3 <3 i have a mayjor over obsession too and im perfectly fine with it ;) yeer like amzingly haawt I LOVE YOU SYNYSTER GATES ! :D <3
hey syn!! como estas ? hablemos en español ;) me gustaría conocerte!! por favooor! love you <3
RAWEERRRR! *~* the hotest man ever!!!!!!!! ♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥
hey synyster (;
I am Lena from Indonesia
I really admire you and hope to god to be met by you (:
I love you <3 <3 <3
stop being so hot!!!!!!!!!!!!!!!!!!! *~* *~* *~* *~* *~* *~*
the best guitarist in the world, in the best band in the world
synnnnnnnnn! i love you! ahhh your so sexy!
i want to meet you so badly!
<3 times a million!
Synyster gates is if not the best, one of by far the best guitarists in the entire world, no, the UNIVERSE!!!!
Rock on Syn
Mikey Deathwish
GATESSSSSSSSSS , melhor e maior guitarrista do MUNDOO !
WooooW!! u look Really HOT..... Me encanta la forma en que tocas la guitarra electrica.....
my favourite guitarist....of all tym....one hell of a guy....
OHHHH To stand on stage with him and play guitar would be freaking amazing !!!!
OHHHH To stand on stage with him and play guitar would be freaking amazing !!!!
Oh My God, Syn is so freaking awsome!!! i <3 you so much, please come n tour in UK again so i can see you guys live!! PLEEEAAASSSEEE!!!!!
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People's Bank of Commerce/Oregon+ Add to Watchlist
As of 20:10:00 ET on 05/18/2015.
Company Profile for People's Bank of Commerce/Oregon (PBCO)
Peoples Bank Of Commerce is a community bank that operates an office in Medford, Oregon. The Bank provides commercial, consumer, real estate, and SBA/Government loans to individuals and businesses.
Contact Information
People's Bank of Commerce/Oregon
750 Biddle Road
Medford, OR 97504
United States
Phone: 1-541-776-5350
Fax: 1-541-774-7666
Key Executives for People's Bank of Commerce/Oregon (PBCO)
|Mike SickelsChairman
|Kenneth D TrautmanPresident/CEO
|Russell E MilburnChief Financial Officer
|Jeri RenoCOO/Secretary
|John A BoydChief Credit Officer
|Bob RasmussenVP/Manager
|Steve YoungVP/Manager
|Janice BrighamVP:Construction Lending
|Cindy GloverVP:Commercial Lending
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|Amy BullionManager:Central Point Branch
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Paul Drew Clement (born June 24, 1966) is a former United States Solicitor General and current Georgetown University legal professor.
Real Madrid Carlo Ancelotti Gareth Bale David Beckham Arsene Wenger Zinedine Zidane Solicitor General Cristiano Ronaldo Champions League Manchester United George Huguely Football Focus Premier League Bayern Munich West Bromwich Albion
Paul Clement: "The score today allowed us to rotate some players which is always a useful thing."
Paul Clement: "There are 3 games in the next 8 days so its great to see the team gel so well. We must keep the pressure on Barca."
Paul Clement: "Its great to have JAmes back as its to see all the others after an international break."
Paul Clement: "It's been an entire team effort, especially in those 5 goals from Cristiano."
Paul Clement: "We are very happy. We didn't expect we'd end up scoring 9 goal!. So very happy with the result."
"Paul George announces he will return on Sunday
if mclaren is to depart the club, a good replacement could be Paul clement, no.2 at
… "you haven't shown me that Paul Clement is better than most local attorneys." I mean, of course he is.
karanka if boro don't go up and Paul Clement from Real Madrid. Only 2 I heard.
The curious case of man with undeniable influence around Europe!.
Paul Clement's hourly rate slashed from $1,100 to $300 in gun case:
Solicitor General of the Republican Party Paul Clement charges $1,350 per hour.
Clement and Legal Team See Award Slashed in Gun Case: Paul Clement, the former U.S. Solicitor General who is now a…
"Everything is about communication as a coach, everything" - Paul Clement, Real Madrid 1st Team Coach
Wenger needs to hire Paul Clement to the staff and spend the summer with Joachim Low.
Clement asking his Qn in a P.Conf with Paul Kagame. He is one of the young and Courageous journalists in Rwanda
Clement is cheating on you, We can say that it's belong to the idea of progress
talk about a neglected position, Neil Clement & Paul Robinson are the only FBs that impressed me tbh
A Response to Neil Katyal and Paul Clement on the Meaning (opinion) of a Natural Born Citizen Harvard Law Review
Paul Clement, an idol for any youth coach, from PE teacher to Real Madrid!
Think a Thomas Tuchel or a Paul Clement is more likely.
Really want us to go after paul clement in the summer like. It's another unproven manager but I think I'd rather that than who's available
that's the issue Ellis needs to sort out. The best candidates are employed elsewhere. I'd go for Paul Clement if he's interested
QPR: Clement back on QPR radar: Queens Park Rangers have been put on high alert after Paul Clement admitted he...
Exclusive interview with Real Madrid's Paul Clement tonight on - his focus on retaining Champs Lge:.
Tim Sherwood is the frontrunner to become the next QPR boss, with Steve McClaren and Paul Clement also in the frame.
QPR appoint Chris Ramsey as manager but Paul Clement still long-term target. By
QPR are chasing Real Madrid No 2 Paul Clement? "Hi Paul. How do you fancy sacking off Ronaldo and Bale for Taarabt and Cau…
Paul Clement: "Cristiano Ronaldo will be out practicing virtually every day after training, particularly central free-kick…
Paul Clement: "Cristiano Ronaldo is so good at central free-kicks because he continually practices them."
Paul Clement: "Cristiano Ronaldo doesn't think he is the best but he wants to be."
Arsene Wenger has reportedly given the green light to Real Madrid assistant Paul Clement replacing him as Arsenal manager at the end of next season. Clement was surprisingly linked with a shock move to the Gunners this week, with the club's board believed to be keen on hiring the Englishman to replace Wenger. And now reports in Spain say Wenger is happy with the idea, with Clement being lined up to arrive at Arsenal at the end of next season. The 42-year-old has never held a manager job but has experience coaching at Chelsea, PSG and now Madrid.
Daily Mail | Real Madrid assistant manager Paul Clement is one of the candidates short-listed by Crystal Palace to take ov…
Paul Clement displays his Castellano (Spanish) during training, and has a short chat with the camer…
Paul Clement fast becoming one of Europe's most wanted managers in the making
Arsene Wenger 'agrees' for Paul Clement to replace him as Arsenal boss next season:
Check out Paul Clement talking about his role at
Just watched a documentary about Paul Clement. Amazing story. Think he could make a good manager one day.
clement was discipled by Paul..how is he roman catholic based lol. He wrote just few decades after jesus
Moreover, Clement implied they were martyred there. Gauis of Rome, AD ~200, associated Peter and Paul w/ Rome.
Clement of Rome (c. 96) and Ignatius of Antioch (c. 116), writing to Rome, associated Peter and Paul being there.
Congrats to Paul Clement on his 75th SCOTUS argument. I remember prepping him for his first DC Circuit argument.
Paul Clement celebrates 75 oral arguments before (most recent being the Amazon screening case) via
Paul Clement celebrates a rare milestone -- his 75th oral argument before the Court.
next ENG manger Paul Clement. Currently the best British coach learning in the best possible environment.
75 argmts for Paul Clement—1 of the 2 best advocates I've ever seen. (Other—
Great recent SC oral argument by WI native Paul Clement. Love how he refers to opposing counsel as "my friend."
Paul B.Clement has a show on 2014-10-17 at 20:00 @ Bowraville recreation... in Bowraville, NSW
If it's good enough for Paul Clement it's good enough for me
I would take Paul Clement all day long if it was an option. MOT
can you please see if Paul Clement is available to take over? Young, innovative coach who will give us identity we r lacking!
Redknapp out - Paul Clement in. Innovative coach. Will give us an identity & tactical nous in modern game.
ps - Paul clement was SK's assistant at Rovers, and even he made that list!!
go ask your Minister Paul Low, who gave him stats, u r so new bro
That's what you get for not hiring Paul Clement WBA
Beautiful night for some Canalside football. St. Clement/Pope John Paul II
Paul Clement is the man. Started as a PE teacher and now he's the assistant manager of Real Madrid!
de Boer,Hoddle,Patrick Kliuvert,Paul Clement or if we had ov getting rid in the summer Claudio Ranieri.
I like the look of Paul Clement, he should replace Pardew.
I haven't had a chance to watch my Paul Clement interview on Football Focus yet as I was at the game, but check it out. Gd insight from him
So many talented coaches out there, screaming out nd desperate for a chance as a manager. Paul Clement for one. Get him in
Phil Neville on Football Focus 'the grass isn't always greener' talking about Paul Clement... A lesson he and others could have heeded!
I agree with Phil Neville, I think Paul Clement can offer a lot to our national set-up.
Paul Clement to be the manager of England with Gary Neville as his assistant wouldn't be a bad bet. After Euro 2016 that is.
In reply to how get the best out of & Bale - "The best most talented footballers are the most professional" - Paul Clement
Paul clement has been assistant manager at Chelsea, PSG and now Real Madrid, wow
Would like to see Paul Clement in management soon, I reckon he'll be good!
Also an interview with Paul Clement & we'll be talking v . Football Focus 1210
Paul clement will be a top top manager. I don't see why people haven't tried to appoint him
Watching Football Focus on Great feature on Paul Clement. Looking forward to Exiting to follow Clement's career
Quite excited to hear Paul Clement provide a update with a focus on issues.
How well has paul Clement done. Assistant coach at psg 2 years ago and now at Real Madrid. An englishman with a dream job there
1/2 Real Madrid assistant manager Paul Clement admits it is a "challenge" to keep so many of the most talented footballers in the world
R.Madrid assistant coach Paul Clement: It's a big challenge [keeping everyone happy], particularly for the manager. http…
Has Cellino considered Paul Clement (Real Madrid) or Karl Robinson (MK Dons)? Both appear to be valid options.
Bringing out the big guns, the A4A case was filed by Paul Clement, a former Solicitor General.
Gareth Bale talking to Carlo Ancelotti's assistant coach Paul Clement ahead of today's training session in LA.
All Star Roster for tonight vs at Paul Walsh Field in New Bedford. Pitchers:. Jared Clement,...
Paul Clement for England manager? Might as well try something different...
Take our UEFA badge trainees on international trips and secondments to develop a managerial talent pipeline: eg Paul Clement.
The job is a role for a modern coach not an old manager with 21 jobs in 38 years. Offer it to Paul Clement. He's the ideal choice.
thats difference of opinion. I like Paul Clement.. The FA need to look at people like him
international level, I feel either a top coach (Paul clement) or a vastly experienced int player could do well
we need a young bright manager like a Paul Clement from Real Madrid to encourage young exciting grass roots football!!!
If I said the name Paul Clement would you know he was ?
Time for a fresh start. Get Karl Robinson/Paul Clement/up and coming type in, maybe with guidance and given time to progress
If England want to appoint an English coach, they should look at Paul Clement. He improves players
Nice effort Roy. Not being brave enough to pick JT and Cole was always going to be your undoing. Best of luck to Paul Clement in Euro 2016.
Which three friends have always been there for you or... — France = clement, Paul, lisa. England =Austin, Lauren,...
Loving the Paul Clement video interview Masterclass series on the FA Licensed Coaches Club website
Loving the Paul Clement Masterclass video interviews on the FA Licensed Coaches Club website.
what happened to neil Lennon brad friedal and Paul clement
"Dave Hockaday appointed new Leeds Head Coach still getting Paul Clement?
I think former SG Paul Clement has written far more persusasively than Larry ever has on this score; see,
Didn't I read that had signed up Paul Clement and Brad Friedel for the ?? Where are they? Kerr is wrecking my head
He wants a Coach "Yes Man" & not a Manager but was hoping for someone like Paul Clement! Cellino will manage it all though
Teamsters retain legal heavyweights Paul Clement, Viet Dinh in bid to end government oversight of the union.
.Paul Clement it should be noted represented pro-DOMA forces infront of SCOTUS - wonder how *** Teamsters feel about retaining
Teamsters have retained Bush-era legal heavyweights, Paul Clement and Viet Dinh, for effort to end government oversight of the union.
"It won't happen again," promises Eamo. Worrying times with his Spanish Football Expert post under threat from Paul Clement.
Southampton, Leicester and Watford these are the world beaters Hockaday has coached. I want to see Paul Clement get it instead.
will be the 2nd Professor to receive the after Paul D. Clement in 2013
I would love to see Paul clement at leeds united as coach
Vincent de Paul was canonized by Pope Clement XII on June 16, 1737.
warnock was a well known quantity lol, i agree id rather have someone with a bit of pedigree. Paul Clement?
Paul Clement takes Citizens United to its logical conclusion: cc:
Omg let's bring this in it's awesome and hilarious
Dumbest Legal Argument Ever?: Paul Clement is widely considered one of the most brilliant...
Paul Clement at Madrid, out of the box.
WBA have started talks with short listed candidates for the manager job. Paul Clement remains the front runner. Derek McInnes, Glen Hoddle, Gianfranco Zola and Steve Round are also definite possibilitys. Chris Hughton, Neil Lennon, Dave Jones and Brian McDermott are also unlikely to fill the hot seat along with Malky Mackay. Tim Sherwood and David Moyes are still not ruled out although it seems unlikely.
My preference would be Hoddle or DiMatteo and as a left field shout Paul Clement he's now ready to be his own Head Coach f…
Florentino and future Ancelotti speak at a luncheon in Madrid They met after the presentation of a book on ten European cups of Real Madrid. Casillas, Illarramendi , Zidane, Clement and the signings were on Ancelotti mesa.Carlo Florentino Perez and general director of Real Madrid, Jose Angel Sanchez , had lunch at a restaurant frequented by white president to talk about the future , according to The Confidential . Florentino Perez and Ancelotti agreed shortly before the presentation of the book " The Tenth . Kings of Europe 1956 -2014 ' , in which the Italian coach was the last speaker of Champions , won last Saturday against Atletico . Florentino and Ancelotti spoke of the future and of the issues that has to solve the club: Casillas situation , the possible migration of Illarramendi , hiring one or two midfielders , the possible arrival of a nine, Benzema situation and possible Diego López sales ( with sale of Naples) and Morata ( deal with Juventus ) . Zinedine Zidane destinations and Paul Clement , a ...
Real Madrid assistant coach Paul Clement has ruled himself out of the running to become the new West Brom manager.
After revealing his desire to step out of the shadows at Real Madrid and get into management on his own, Paul Clement is now being touted for a return to England with West Bromwich Albion.
I was thinking, If we get Paul Clement from Real Madrid as manager... Ronaldo and Bale on loan in the La Liga winter break?
Paul Clement: Chelsea Under-16s to European Champion in seven years. Congratulations to him, Ancelotti and the other ex-
Paul Clement was a PE teacher at glenthorne now the assistant manager of Real Madrid in the Champions League final
I don't want Paul Clement as our new boss, assistant and coach all his life. No just no
Paul Clement definitely man in charge at Madrid training. Overseeing all drills, shouting at players to up intensity, all en español too.
Paul Clement overseeing drills at Madrid open training just now
Albion fans have been told it would be "very difficult" for the club to bring in Paul Clement as their new boss.
Watching the Champions League finalists in training. Carlo Ancelotti watching on as Paul Clement barks out the orders
Definiteness of purpose is the starting point of all achievement. – W. Clement Stone
This pretty much sums it up Paul Clements
Join an audience with World famous International writers at The Immrama Festival of travel writing in Lismore county Waterford from June 12th to 15th. Enjoy talks with award winning author Tim Butcher, broadcaster Charlie Bird, or join 'The Festival Man' - Mark Graham for a literary breakfast Don't miss the panel discussion with a host of travel writers chaired by special guest Paul Clements and a writing workshop with Manchan Magan. With free family fun on Sunday with Music & entertainment in the park and the Farmers Market Extravaganza at the Castle Avenue. The Immrama Festival of Travel Writing - June 12 to 15 – for tickets see lismoreimmrama.com
NEWS / SPORT East Coast Athletic Club was well represented at the opening race of the East Antrim Harriers Forest Series race in Ballyboley Forest this week. James Brown led the black and yellow vests home, completing the 4.2-mile course in 23:41; this was enough to take second place. Andrew Guy (24:50) and Greg Lavery (25:35) both produced notable performances, taking fourth and sixth place respectively. James Robinson (14th place – 27:24) and Naoise McLoughlin (16th place – 27:41) finished just 17 seconds apart before Janice Plumb claimed third place in the ladies' race; the ever impressive athlete covered the undulating course in 30:46. Lee Stirling crossed the line in 32:44 (36th place), while Belfast Marathon finishers, Paul Clements and Sandy Plumb looked strong as they returned to competition. Clements ran 36:21 (58th place), with Plumb following in 38:56 (71st place). Angela Burns completed an excellent night of racing when she recorded 42:56 (26th place lady).
Would like to see Paul Clement at a young coach with experience. Ireland u21, Chelsea *** & Real Madrid *** with Carlo
Is Paul Clement in the running for Albion HC job?
My last essay was proofread in the style of Paul Merton, Clement Freud, Gyles Brandreth and
Sunday Mirror: Brighton are hoping to make Real Madrid coach Paul Clement their new manager.
As if Paul Clement is going to Leave Real Madrid for Brighton. Only way that will happen is if Ancelotti gets sacked
Would like to thank every one for giving my prince Isaac a good weekend He's started his new little job and hes loved it Maureen Kirby Vicky Bland Paul Clement
Tonight I am sat here a very proud captain! Over the last 6 months we have played against teams like Plymouth Argyle, battled all weathers and pitches but can now say that we Exeter City have won the league title 2013/2014! It has been an honour to play for Paul Clements he has changed me as a person and made me team captain! He believed in me and I grew as a player which was reflected positively on the team! It's been a headache at times but I'm so proud of them all! F.A Cup semi-Final and League Tile Champions not bad for my first season! Got few more talented youngsters lined up ready to come into the team next season! Well done boys time to kick back and have fun over the summer! Was nice to have mum and dad see me lift the trophies today there support gets be through!
See Paul Clements we're far tougher than spam lol
been up a mountain, who is Paul Clement?
Paul Clement would be superb. Would bring so much experience. Sherwood brings a gilet.
"In front of the Justices were two legal heavyweights: Paul Clement and Solicitor General Donald Verrilli Jr.,"
" Carlo Ancelotti and Paul Clement, over to you.
Carlo Ancelotti and Paul Clement, over to you.
The oral arguments for American Broadcasting Co. v. Aereo are up (with Paul Clement - this guys calendar is _full_):
Hobby Lobby lead counsel Paul Clement recaps oral arguments in the Sebelius v. Hobby Lobby landmark case
Good Monday morning America! Would you pray this prayer out loud with me today. "Dear Father God.we pray today for David Green and Hobby Lobby today as their case goes before the United States Supreme Court tomorrow morning.we pray for this company who represents thousands of employees in 40 states in America and thousands of other small businesses who are challenging the Abortion Pill Mandate that would force them to pay for life-ending drugs or face crippling fines.Lord we know that the outcome of this hearing will have a dramatic impact on our religious freedoms in America.we pray for Paul Clement as he argues this case before the highest court in the land on behalf of the Green Family and also the Hahn families and their Christian companies.we pray for wisdom for this attorney.as he speaks the truth before the U.S. Supreme Court.we pray for all of the nine Justices including Antonin Scalia, Anthony Kennedy, Clarence Thomas, Ruth Bader Ginsburg, Stephen Breyer, Samuel Alito, Sonia Sotomayor and Elena K ...
Great show on talksport tonight. Real Madrid asst Paul Clement and now Kenny Sansom
Kaizer Chiefs coach Stuart Baxter is being linked with the West Bromwich Albion job. Baggies chairman Jeremy Peace travelled abroad to speak to a candidate for the vacant head coach position last week, fuelling rumours that he could be targeting Real Madrid assistant coach Paul Clement or Baxter, currently in charge of South African side Kaizer Chiefs. Spaniard Pepe Mel is also being linked with the post.
kaizer Chiefs' head coach, Stuart Baxter, has been linked with the vacant post at English Premier League side, West Bromwich Albion. The 60-year-old recently signed a new two-year deal with the Amakhosi, committing himself to the club until 2016, although it seems that he is still being monitored by other clubs abroad. Baxter has previously coached in England, working within the Three Lion's youth set-up, as well as spending time in Sweden and Japan. It seems unlikely that, after signing a new Chiefs contract, Baxter would be willing to depart from the club that he has led back to the top of the PSL standings, however it cannot be completely ruled out. In their article they stated, "Of those potential recruits, only Paul Clement, No 2 to Carlo Ancelotti at Real Madrid, and possibly Stuart Baxter, one of Hodgson's former pals currently working in South Africa, sprang to mind. But neither has frontline experience in the Premier League." Baxter led Chiefs to a league and cup double last season in h ...
The Real Madrid first team squad (with the exception of Sami Khedira) along with Carlo Ancelotti, Zinedine Zidane and Paul Clement posed with the official 2013/2014 suits at the Santiago Bernabéu. The Whites and Versace signed an agreement according to which the Italian fashion house will dress the coaching staff and players over the current season.
Westbrom wants Real Madrid assistant Paul Clement as their new head coach;;;#
Paul Clement representing George Huguely in VA state appeal (report on oral argument Wed.) by
Wow. I hadn't known that George Huguely had hired Paul Clement for his appeal $$$
George Huguely, serving 23 for killing Yeardley Love, appealed for a new trial. Lead atty. Paul Clement.
Upcoming SCOTUS case on corporate religious rights features attorney Paul Clement on behalf of corps. Why do judges lo…
Paul Clement the Real Madrid assistant coach only played non-league & concentrated on coaching from age 23
Paul Clement on arguing before w/o notes: "The questions are so important ,,, you really don't want anything to distract you."
Fmr SG Paul Clement on "J. Breyer asked me a question that only J. Breyer could ask, which is to say it had many parts."
I can think of 5+ alternatives - no need to be English based. Paul Clement from PSG would be interesting...
Yes, well said. I don't see the same alliance yet between Bale and Ancelotti. Perhaps Bale has it with Paul Clement now.
Seeing Paul Clement in RM dug out makes me happy.
Paul clement has done very well assistant at Chelsea with Carlo then PSG and now Real Madrid his doing bits!
How did a PE teacher from Sutton become a coach at Real Madrid? Here's the story of Paul Clement
Great interview with Paul Clement on SSN. Hopefully it's on Sky Sports website later.
I know you must be getting loads of suggestions but any chance of an attempt at getting Paul Clement?
Paul Clement's my new favorite. Try and get Hoddle involved and that would be unbelievably awesome. Someone on BBS suggested it
Excellent report by Paul Clement on federalism & states' rights to enact legal reform
. First one that comes into your head mate I don't mind who it is.. I'd go with Paul Clement and
Smooth plug from the excellent for interview with Paul Clement
So awesome to see Paul Clement on the bench next to Ancelotti and Zidane and now giving orders to Bale. Great story.
So accelotti and Zidane wear suits and Paul Clement goes on wears a tracksuit lol
Is that the same Paul Clement that played gor Chelsea and WBA?? Wow I never knew he was coaching at Madrid. Thats great
Anyone else watching Sky Sports 4 expect Paul Clement to have a French accent!?
As if Paul Clement just called Real Madrid 'More than a club' how dare you.
After assisting Carlo Ancelotti at PSG and Real the FA should look at getting Paul Clement involved in the future
Paul Clement, asst coach Never made it to So s'ok 4 top top players 2 walk into top managerial roles, right?
Paul Clement interview on Revista is fascinating, one of the best coaches in football
Right-hand man: Paul Clement's rise through the coaching ranks has been remarkable.
Assistant boss Paul Clement tells Revista about his route to the Bernabéu and his mission in Madrid. on
Paul Clement (RMadrid assistant ) " Hes a fantastic player, Messi is one of the greatest players to play the game " ...
I like the cut of Paul Clement's jib.
Watching as a football coach and sport scientist, aspire to be like Paul Clement, coach @ Real Madrid!!
Argentina sics ex-Solicitor General on hedge fund: NYP – Former Solicitor General Paul Clement has been hired ...
6pm SS1HD We'll hear from another Brit in Madrid, Real's Asst. Coach Paul Clement. Gaizka & Graham join us as we gear up for El Clasico Q's?
From Battersea Park to the Bernabau - how Paul Clement went from coaching in Sutton to Real Madrid
Realmadrid assistant coach paul clement is a fool to say Gareth Bale is not guarantee to start.
Real Madrid assistant manager, Paul Clement is elated by the club's massive transfer of former Tott...
Gareth Bale will have to work to be success at Real Madrid , the club's assistant coach Paul Clement and former star Ronalfo say.
Sure - thats why you paid $120mn for him, to keep him on the bench...
It is in broad agreement with the Gospels, Paul, Clement, Irenaeus, Chrysostom, and so on through the ages.
Bale 'not guaranteed' a start at Real
Bale 'not guaranteed' a start at Real : Real Madrid news
Real Madrid *** coach Paul Clement says Gareth Bale is not guaranteed a starting spot and must "prove his worth" 100 million on the bench?
Jum. How wud you describe, Real's assistant coach paul Clement comments? Gareth Bale is not guaranteed a start?
Bale not guaranteed start says Paul Clement. Now that (if he's benched) would be hilarious. Even Torres will laugh at him.
Training Report | Zidane and Paul Clement took charge if the session as Varane underwent field training.
"Bale not guaranteed at start at Real: Who saw that coming ???
Bale not guaranteed a start at Real:
"Bale not guaranteed at start at Real: 85 mill man on the bench loool
Real Madrid assistant coach Paul Clement: "There's a lot of competition for places. No-one will be guaranteed anything."
Paul Clement: "Coach Carlo Ancelotti has a clear idea how to use him but things can change."
"Bale not guaranteed at start at Real: your grammar is shocking!
Paul Clement: "Carlo is flexible enough to use Gareth and other players in different capacities."
Paul Clement: "It'll be interesting to see how players fit together. We'll try to find their best position and what's best for the team."
Paul Clement: "Benzema is a great talent, while Isco plays in midfield but has chipped in with three goals already."
Bale not guaranteed at start at Real:
is not certain 2 start 4 Real Madrid says assist' coach Paul Clement via so is he 4 marketing hype or what?
Paul Clement spoke volumes. World record Bale, not guaranteed a start. At Spurs he was "the star", in Madrid, one of 'many' stars. Reality.
Madrid assistant coach Paul Clement says Bale may not be on the starting 11. Gulp.
Gareth Bale is not certain to start for Real Madrid despite being the world's most expensive player, says assistant coach Paul Clement..lol
Gareth Bale must earn his place, says Paul Clement - Gareth Bale will not be guaranteed to start every game at Rea... ht…
Real Madrid's ex-Sutton PE teacher turned coach Paul Clement tells me what he thinks of £85m-man Gareth Bale:
Madrid. where it was announced that both Zinedine Zidane and Paul Clement will be his assistants
So Paul Clement followed ancelloti to madrid.
[CapitolAlert] California prisoners retain ex-Bush appointee in court case: California prison inmates have an ...
Paul Clement aids California prisoners at Scotus: inmates have an ally in famed Supreme Co...
inmates have ally in litigator, & former Bush SG, Paul Clement, as they fight state
Citing the Windsor case, House Republicans & Paul Clement, will no longer defend DOMA.
Instead of helping families, children GOP wastes millions on hate.
New on LGR Paul Clement Starts Abandoning Defence of DOMA In Courts: That is the end of that. House Republican...
Paul Clement loses another one. BLAG seeks leave to withdraw from defending DOMA in other cases:
I also love the staff assembled by Carlo Ancelotti for Real Madrid. Zinedine Zidane, Paul Clement, Fabio Cannavaro are solid acquisitions
partner Patricia Millett has been backed by Ted Olson, Paul Clement, Ken Starr and Greg Garre.
Real Madrid have a dilemma with Aitor Karanka Aitor Karanka still has three years left on his contract at Real Madrid but he will not be the number two as he has been for the past three season. He declined leaving and following now Chelsea manager Jose Mourinho to London because of family reasons and has left Real Madrid with a dilemma on what to do with the Basque coach. Eurosport has reported that the former defender's contract pays out half a million euros net per year with no role for him on the first team and neither in Castilla, Real Madrid's youth academy. What the Madridista's seem to be waiting on is for Karanka to find a new gig for the upcoming season. The arrival of Carlo Ancellotti as the new manager of Los Blancos has placed Paul Clement and Madrid legend Zidane on the bench as his assistants. Rewinding to last summer when Mourinho signed a contract extension to 2016, the agreement also brought a raise in salaries to his coaching staff, Karanka included. According to Eurosport, Karanka ...
Zinedine Zidane and Paul Clement have been confirmed as Carlo Ancelotti's assistant coaches at Real Madrid for next season. It was heavily speculated that former Madrid midfielder Zidane would be named on the bench alongside the newly-arrived Ancelotti, having requested so over the position of sporting director to President Florentino Perez.
Chelsea have kick started the careers of quite a few: Villas Boas, Steve Clarke and now Paul Clement, Brendan Rodgers.
Zinedine Zidane will be Ancelotti's assistant Zinedine Zidane will become the new Real Madrid assistant manager after the arrival of Carlo Ancelotti at Los Blancos. L'Equipe journalist Frederic Hermel gave the exclusive to late night Spanish sports TV show Punto Pelota and Ancelotti himself confirmed it in his presentation: "He will be a good assistant. The only problem is he won't be allowed to play", the Italian joked. Although Florentino Perez wanted Zizou to be the technical director, the French legend will fulfill his desire of starting a coaching career. Zidane has been doing the football manager courses and has been reported to need to pass just one more subject to obtain the license. Zidane will replace Aitor Karanka, former assistant coach during Jose Mourinho's era, and will form a team with Paul Clement, the other assistant manager, who had already worked alongside Ancelotti at Chelsea and Paris Saint Germain. The managment team will be completed by Italian veteran Giovanni Mauri, w ...
Paul Clement in the frame at the moment. He was Kean's number two at Blackburn. Odds have been slashed by the bookies but not worth using them as a guideline. He's currently at PSG and therefore explains Berylson's meetings in France. Thoughts?
The Lynde and Harry Bradley Foundation in Milwaukee has announced that one of four 2013 Bradley Prizes will be awarded to Paul Clement, the former Solicitor General of the United States. During his tenure, he represented the U.S. government in many cases involving national security and civil rights. The award will be presented to Clement during the 10th annual Bradley Prizes ceremony that will be held at The John F. Kennedy Center for the Performing Arts in Washington, D.C., on Wednesday, June 12. Each award carries a stipend of $250,000. One of the preeminent attorneys of his generation, Clement has argued more than 65 cases before the U.S. Supreme Court. He is a graduate of Georgetown University's School of Foreign Service and Harvard Law School. Clement served as a law clerk for Justice Antonin Scalia. He is currently a partner with Bancroft PLLC. "Paul Clement has an impressive record of achievement," according to Bradley Foundation president and chief executive officer Michael W. Grebe. " ...
What's the most important tool in the book designer's arsenal? These days, for most designers, you'd assume it's the Adobe Creative Suite. But Massimo Vignelli isn't most designers, and as we see in this charming video by Pentagram's Michael Bierut, Vignelli keeps things decidedly old school when he...
Avoid disaster and embarrassment by following these simple rules.
Call it The Case of the Missing Three Billion Dollars. Auditor General Michael Ferguson says he cant find any trace of 3.1 billion that was given to 35 federal ministries and agencies to fight terrorism. Hes looked everywhere. He cant say for sure whether any of the money ever went…
SABAH The feelings on the ground seem to indicate a rising tide of support for the Pakatan. A nightmare scenario for the BN.
DuPont wants hearing closed in trade secret case. Paul Clement, for rival company, says keep it open
Thank you to Circus Mojo for donating their time and teaching us all healthy ways to cope with stress!!! Lot's of laughter, smiles and coping, thank you again!!!
MA BEAUTFUL cster hellen she iz coming GUD in singing.
MONEYBAGS Paris Saint-Germain are desperate to keep David Beckham beyond the end of the season, according to assistant coach Paul Clement.
Did Starkey just slag off Clement Atlee? Really? I hope he gets hit by something ironic, like a cavalry charge.
This channel offers news coverage of the main activities of the Holy Father Pope Francis and of relevant Vatican events. It is updated daily. Video images ar...
Pope Linus was pope from c. 67 to c. 76. According to several early sources, he was the second bishop of Rome after Saint Peter, making him the second pope. According to other early sources, Pope Clement I was the pope after Peter. Linus and St. Clement are the only persons specifically mentioned in...
for those coaches wanting to work professionally in football.also very touching story regarding Nick Broad.
Le Championnat: Beckham impresses PSG coach: PSG assistant coach Paul Clement says he has been impressed with ...
According to assistant-manager Paul Clement, David Beckham could extend his stay at Paris Saint-Germain beyond this season.
if do replace Pardew, what are your thoughts on Paul Clement? Knows the french culture, could be looking for a PL job
PSG want David Beckham to sign on again: Paris ST GERMAIN assistant coach Paul Clement is hopeful David Beckha...
A behind the scenes look at Kollaboration Los Angeles 2013 Auditions. Over 50 pre-screened performers auditioned to compete at Kollaboration Los Angeles and ...
David Beckham is a pleasure to work with says Paris Saint-Germain assistant coach Paul Clement and hopes he'll enrol for another year.
Following his defense of DoMA, his attack of the ACA, and his tenure as Bush's Sol. Gen. Paul Clement now defends murderers. Classy.
PSG assistant coach Paul Clement has described David Beckham's arrival at the club as "a breath of fresh air"
Paris St-Germain assistant coach Paul Clement has hailed David Beckham's impact at the club and hopes he will extend his stay.
David Beckham has been a positive influence at PSG and could extend his stay in the French capital, says assistant coach Paul Clement
Clement pleased with Beckham PSG effect: Paris Saint-Germain assistant coach Paul Clement has spoken of h...
Beckham impact praised by PSG coach: Paris St-Germain assistant coach Paul Clement says his club hope that Dav...
Paul Clément Straub They ARE banned - where on the world do You see governments worthy of being respected as...
its a rare gem. With Rockwell & Jemaine Clement's best film role to date, there's a lot to love.
United States Solicitor General does not think much of " visiting " Judges and their Opinions
Suarez has been given a longer ban than when a Arsenal player PUNCHED someone, BREAKING THEIR JAW (Paul Davis in 1988).
Met PSG Coach Paul Clement today with and Top fella and a great story of rise thru ranks for us aspiring coaches
Bill Clement show is tonight at Chickie's and Pete's Audubon at 6pm with special guest GM Paul Holmgren
"We all dropped our highlighters and laughed!" "Paul Clement Disses Judges Sitting By Designation
what? no! Paul Clement 's oral argument perfection--even when I think he's so totally wrong--is my constant.
Rare Paul Clement misstep: appeals ruling from visiting trial judge worth less ("not Marbury")
The final Bill Clement Show of the season will be in Audubon tomorrow night and special guest this week will be GM Paul Holmgren
what makes what Paul says more true than Augustine or clement?
St. Apelles (1st c.) Mentioned by St Paul in Rom 16:10. First bishop of Smyrna; martyred with Sts Lucius and Clement. Brothers, pray for us.
Uno mas: "FN Values sit at the heart of good investment"- Paul Clement-Hunt..Rad
Also great to see Paul Clement -a young English coach,worked his way through and gaining brilliant experience working abroad at PSG
After the procedural stretch in Genesys, Paul Clement can't be feeling good about his chances in Italian Colors.
Thatcher going from St Clement Danes to St Paul's? Hardly worth getting a gun carriage out is it?
Paul Clement's brief against ICWA is very strong.
Looking forward to being on a panel today with the fabulous and my appellate lawyer crush, Paul Clement.
Photo: hommemodel-s: Baptiste Radufe and Clement Chabernaud backstage at Paul Smith AW13
Martha Hall Findlay with less votes than Tony Clement or Peggy Nash, more than Paul Dewar or Nikki Ashton
Because Clement Attlee wouldn't have wanted to cost the country millions. Unlike
Thatcher's Funeral "A 19-gun salute will be fired from London Bridge during each minute of the procession from St Clement Danes to St Paul's
Paul Clement seems to be a person remind to work for change in this country.
I guess if Lisa Blatt, Paul Clement, Charles Rothfeld, and Ed Kneedler are all arguing this case, it's a big deal.
One of most moving images at Churchill's funeral was an elderly Sir Clement Attlee following his coffin up steps to St Paul's
Paul Clement's going to have to backpedal a bit if he wants to continue arguing that congress doesn't have animus:
Paul Clement: Argues Prop 8 @ SCOTUS during the week, mounts art exhibits on the weekend?
Paul Clement - first team coach at PSG... Former PE teacher, never played professionally. It can be done!
same here! Love him and mourinho ! Also found out about Paul clement too!
Paris St Germain coach Paul Clement sets sights on management after being endorsed by Carlo Ancelotti.
Paul Clement from talking all about -I just downloaded the new app
It has to be said, PSG assistant Paul Clement has come a long way from working with Don Givens with the Under-21's.
Great to see Paul Clement (an English coach) next to Ancellotti on the PSG bench!!
At hearing, Dem senators note Srinivasan's support from conservative legal stars like Paul Clement and Ken Starr.
NFL, ex-players present concussion case arguments: NFL attorney Paul Clement said these matters should be deci...
coach Paul Clement has revealed that he is hopeful of one day managing in the
If this is the Lebron James of Law, are you the Rony Seikaly?
PSG Coach Paul Clement Eyes Up Premier League Job: Clement hoping to find himself in the dugout at a Premier L...
Paul Clement's rise from PE Teacher to assistant at
NFL lawyer Paul Clement in court today today (via
Paul Clement's client, the 32 NFL team owners, are crazy for letting this veer into court. Needlessly will affect their pursuit of happiness
If Paul Clement isn't an inspiration to coaches, I don't know who is!
Inspiration for any coach at any level-
Robert Durst Chris Borland Hillary Clinton Prince Harry Top Gear White House March Madness St Patrick San Francisco Don Quixote Jeremy Clarkson Champions League Kendrick Lamar United Airlines Middle East Kanye West New Orleans Justin Bieber Los Angeles Loretta Lynch Twin Peaks Apple Watch Benjamin Netanyahu Prime Minister Benjamin Netanyahu Islamic State Mitt Romney Pete Rose Jeb Bush Manchester City Saint Patrick Rand Paul Best Photo Internet Explorer 8 Comedy Central Stefano Gabbana Vladimir Putin Secret Service Saudi Arabia Paul Walker Premier League Jimmy Savile James Bond Evander Holyfield Will Ferrell Michelle Obama David Cameron Las Vegas Man City Tony Blair Internet Explorer World Cup Whole Foods Jessica Lange Vin Diesel Howard Schultz Kim Kardashian Dulles International Airport Long Island Ellen Pao Good Reason South Pacific Ray McDonald Robin Thicke White Americans Notre Dame Mad Max North Carolina Molly Ringwald Mariah Carey Marvin Gaye Miles Teller Scott Disick Taylor Swift Wayne Rooney Zlatan Ibrahimovic Grand Slam Nigel Farage Six Nations Hong Kong Century Fox Chris Christie Natalia Kills Mars One Gareth Bale Cyril Smith George Osborne Home Page Manchester United Loch Ness Jeremy Forrest New Zealand Pernod Ricard Prime Minister Benjamin Nou Camp Mutual Fund Marie Slaughter Kappa Delta Rho Kleiner Perkins Jimmy Kimmel Miley Cyrus
© 2015
Carlo Ancelotti Solicitor General Supreme Court Marriage Act Real Madrid Donald Verrilli David Beckham Affordable Care Act House Republicans Ted Olson New Testament Former Solicitor General Gareth Bale Steve Clarke Tom Goldstein President Obama Paris Saint Germain


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The Financial Industry Regulatory Authority has levied $1.2 million in fines on five ING Group units, which the regulator said failed to properly retain and review millions of e-mails in employee accounts. ING will pay the fine to resolve the case but did not admit nor deny wrongdoing.
View Full Article in:Reuters
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Avoid shoveling rock, wood, dirt and other materials out of the box. Standard on some models or available in a package or as an option.
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Enjoy premium audio in your Bobcat® utility vehicle. The radio and speakers deliver big sound and durable construction.
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For a full list of options and accessories, talk to your local dealer.


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Results for Bill Clinton
Faith in Action: A Look at Public Theology Professor Mike McCurry
Originally Posted: 03/26/2014 - 3:13pm | Type: Blog
We talked with former press secretary for former President Bill Clinton and Wesley Theological Seminary professor of public theology Mike McCurry on faith and action. "Public theo ...
Tony Campolo to Shutter the Evangelical Ministry He Started 40 Years Ago
Originally Posted: 01/15/2014 - 11:53am | Type: Blog
Tony Campolo, a progressive evangelical leader who counseled President Bill Clinton through the Monica Lewinsky scandal, announced that the organization he founded nearly 40 years ago will close on June 30. ...
Bill Clinton Urges Supreme Court to Overturn Gay Marriage Law He Signed
Originally Posted: 03/11/2013 - 10:05am | Type: Blog
It's not every day you see an ex-president ask the Supreme Court to strike down a law he signed. It's not every day you see an ex-president ask the Supreme Court to strike down ...
The U.S. and Africa – Where There is Political Will, There Is A Way
Originally Posted: 06/15/2012 - 12:09pm | Type: Blog
This week, the Brookings Institution hosted an event which looked back at the last 12 years of the African Growth and Opportunity Act, which the Institution estimates has created 300,000 jobs in Africa and tak ...
Obama Nominates Physician, Global Health Expert to Head World Bank
Originally Posted: 04/17/2012 - 4:04pm | Type: Blog
In a move that surprised many in the world of economics and politics, on Friday morning President Obama nominated Jim Yong Kim, the South Korea-born physician, anthropologist and president of Dartmouth College ...
Why How We Do Anything Means Everything
Originally Posted: 11/06/2011 - 4:34pm | Type: Blog
How helps us understand that principled behavior isn't merely something a PR/Corporate Social Responsibility staff or attorneys tell us is important. Rather it is the surest path to success and relevance ...
Voices from the Web (and World): Responses to the Troy Davis Execution
Originally Posted: 09/24/2011 - 5:14pm | Type: Blog
"Continuing a cycle of violence through state-sanctioned actions does not bring justice but only creates a culture of death and retribution. " Continuing a cycle of vi ...
God and Class Warfare
Originally Posted: 09/27/2011 - 10:30pm | Type: Blog
The hot phrase in Washington, D.C., this week is "class warfare." The hot phrase in Washington, D.C., this week is "class warfare." Paul Ryan, John Boehner ...
I Am the 9/11 Generation
Originally Posted: 09/24/2011 - 5:14pm | Type: Blog
(This morning's view of Ground Zero from Sojourners and the World Evangelical Alliance's press conference.) (This morning's view of Ground Zero from S ...
Four Reasons Not to Mess with Payroll Taxes
Originally Posted: 07/14/2011 - 8:35am | Type: Blog
Now that President Obama's people have sent out glowing press releases about how wonderful the proposed tax agreement is (<a href="http://www.whitehouse.gov/blog/2010/12/10/a-win-women-mothers-and ...
Bill McKibben's Brave New Eaarth (No, That's Not a Typo)
Originally Posted: 08/31/2011 - 4:40pm | Type: Blog

</a&g ...
Which Party is the Biggest Spender? A. Democrats B. Republicans C. All of the Above
Originally Posted: 07/14/2011 - 8:34am | Type: Blog
In a recent New York Times column, David Brooks laments the loss of the political center. ...
Report from Haiti: Poverty and the Earthquake Collided
Originally Posted: 07/14/2011 - 8:19am | Type: Blog
We landed in Haiti about five hours ago. It has been approximately a week after the major earthquake struck this country. We landed in Haiti about five hours ago. It has been appr ...
Evaluating President Obama's Response to the Haiti Earthquake
Originally Posted: 07/14/2011 - 8:19am | Type: Blog
This morning President Barack Obama promised the people of Haiti that they would not be "forsaken" or "forgotten." Yesterday he told Americans, "We have to be here for them in their ho ...
Mark Sanford, John Ensign, and 'The Family'
Originally Posted: 07/14/2011 - 8:18am | Type: Blog
Presently, the glare of the media spotlight has started to shine on a number of political figures, all of whom coincidentally have a connection to a D.C.-based group called The Family. ...
Mark Sanford's Apology: Neither Sin nor Forgiveness Has any Party Affiliations
Originally Posted: 07/14/2011 - 8:18am | Type: Blog
Over the course of the 2008 election season, I kept hearing from some of my conservative religious friends of the great presidential hopes they had for a smart and ambitious governor from South Car ...
Confessions of an Alternative Voter
Originally Posted: 07/14/2011 - 7:51am | Type: Blog
I'm pretty sure I have more sympathy for Shane and his treatment of what I'll call "alternative voting" (pr ...
Keeping Our Eyes on the Evangel
Originally Posted: 09/03/2014 - 1:06pm | Type: Magazine Article
Jim Wallis What if, in front of the whole world, the U.S. pledged unequivocal U.S. support for the restoration of democracy in Haiti? ...


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Andy Hermann
Andy Hermann has written for L.A. Weekly since 2012 and joined the staff as music editor in 2014. Previously he was the national music editor for Metromix and managing editor for ArtistDirect. His work has also appeared in XLR8R, the Daily Dot, Diffuser.fm, and the Boston Phoenix among others. He lives in Highland Park and still holds out hope for a Talking Heads reunion.
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Luke Babbitt Pictures
PHOENIX, AZ - OCTOBER 12: Luke Babbitt #8 of the Portland Trail Blazers puts up a shot over Luke Zeller #40 of the Phoenix Suns during the first half of the preseason NBA game at US Airways Center on October 12, 2012 in Phoenix, Arizona. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Christian Petersen/Getty Images)


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28 CFR 542.11 - Responsibility.
(a) The Community Corrections Manager (CCM), Warden, Regional Director, and General Counsel are responsible for the implementation and operation of the Administrative Remedy Program at the Community Corrections Center (CCC), institution, regional and Central Office levels, respectively, and shall:
(1) Establish procedures for receiving, recording, reviewing, investigating, and responding to Administrative Remedy Requests (Requests) or Appeals (Appeals) submitted by an inmate;
(4) Respond to and sign all Requests or Appeals filed at their levels. At the regional level, signatory authority may be delegated to the Deputy Regional Director. At the Central Office level, signatory authority may be delegated to the National Inmate Appeals Administrator. Signatory authority extends to staff designated as acting in the capacities specified in this § 542.11, but may not be further delegated without the written approval of the General Counsel.
Title 28 published on 2014-07-01
no entries appear in the Federal Register after this date.


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