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Challenges in Translational Medicine
Cost has been the most significant obstacle for the effective translation of biomedical discovery into clinical benefit. The cost in the early 21st century of carrying a product through production, laboratory testing, and clinical trials to gain approval by regulatory agencies was tens of millions of dollars. Many such products, however, failed to generate projected revenue once they were introduced to the market.
Regulatory burdens aimed at protecting the privacy of individuals as well as ensuring public safety were other important components of the biomedical enterprise. As the threshold for privacy and safety was raised, the cost, complexity, and length of testing increased. The increased sophistication of modern biotechnology has enabled scientists to refine therapeutic and clinical strategies to improve their safety and effectiveness. However, that has led to increased complexity among therapeutic agents, with many newer agents based on the use of cellular substances, the genetic modification of cells and tissues, and the administration of substances that act indirectly on target tissues by altering specific physiological functions in patients. Such products have complicated safety and efficacy evaluations, because most act through distinct mechanisms that have not been fully understood, which makes it difficult to standardize validation strategies.
Obstacles to translational medicine reach beyond the interface between basic and clinical research. Indeed, they have also been endemic in the way in which clinical research has been performed. An administrative structure that segregates clinical scientists according to discipline (e.g., surgery, pathology, radiology, and nursing) functions according to fixed rules and cannot optimize translational science. A goal-oriented adaptive "adhocracy" model, on the other hand, with departments built around a goal rather than a discipline, better suits interactions between experts and fosters communication on a daily basis. Thematic areas built on pathogenetic mechanisms such as cancer and inflammation are much better suited to assisting in fulfilling the missions of health care, teaching, and research. That approach, in the context of translational medicine, has been proposed as being more effective in the clinic than the existing administrative model of fragmentation into different disciplines.
Increased complexity in biomedical research has distanced the laboratory from clinical scientists, and thus there has been a need for clinical scientists who can serve as facilitators of the translational process. However, the training of such individuals has been lengthy and expensive, and incentives have been needed. Moreover, the complexity of translational studies that were dependent on the participation of several experts and often required interinstitutional collaboration did not suit existing models in which biomedical scientists were rewarded according to individual achievement.


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$35 Indian Tablet Has Until March 31st To Ship or Be Cancelled 46
from the too-good-to-be-true dept.
They should just outsource production to Ind... no wait...
It's engineers and target customers were too busy shitting in the streets to bother.
No word on whether the Indian firm is mostly a thin shell of management and a few field engineers who exist to look over the shoulders of the Chinese sub-subcontractors to keep them from swapping in cheaper parts when nobody is looking...
At $35 for a 7" touchscreen tablet, how much cheaper can you get on parts? A Fisher-Price "tablet" [fisher-price.com] (no touch screen, no shift key, has a "10" key instead of a "0," but it does have a light-up LCD screen that changes color) costs $25, and even then consumers in the two-to-five-year-old bracket are refusing to use it because they keys are too cheaply made. What "cheaper parts" could the sub-subcontractors possibly swap in? Horse meat [wikipedia.org]? Melamine [wikipedia.org]?
I can see the reviews now: "Bought these for my kids, but they leak some kind of liquid. Kids won't touch them, but the cat loved it. The cat's dead now, vet said his kidneys failed, so at least I'm saving money on cat food."
Some of my readers ask me what a "Serial Port" is. The answer is: I don't know. Is it some kind of wine you have with breakfast?

subset: commoncrawl


text: http://techcrunch.com – Startup Canada today debuted a $100,000 Indiegogo crowdfunding effort to try and raise money for building an online resource to help entrepreneurs across Canada gain access to crucial support and resources as they build their businesses. The platform, called Startup Canada Connect, will offer resources, access to mentors, and events and associations, as well as generally provide a centralized place where entrepreneurs can rate and compare local community startup services. Startup Canada, a non-profit organization founded by Victoria Lennox and Cyprian Szalankiewicz, is itself a startup, (IT news)


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Priyanka G.
Programmer / Developer
B24 e Solutions is a software company based out of India with a strength of
around 50 people. We work on all the major technologies like C#, ASP.NET,
MSSQL, Visio, Sharepoint, PHP, MySQL, iphone/iTouch, Flash, Flex, Photoshop to
name a few. Backed by our strong quality processes and rich experience
managing global clients across various business verticals, we align software
solutions to your business goals. Quality processes, commitment to excellence
and quick turnaround time are a major part of…
Tests Taken
|Percentile Score
HTML 4.01 Test


text:
Andrew in AZ
These are great shorts and amazing durability.Read All Reviews
Kelly in WA
Worked OK not great, but better than without.Read All Reviews
Bryan in AB
These save my bum big time. Small is tight, maybe ill go for the medium next time. I love the bum paddingRead All Reviews
TIM in Pennsylvania
WE RIDE DIRT BIKES ALL WINTER WITH TIRE STUDS AND THESE GLOVES WORK IN DAYS WHEN IT IS IN THE TEENS.Read All Reviews
Craig in VIC
These are very loose fit on the lower leg, and perfect on the upper. Expected a better fit!Read All Reviews


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- News
- Premium
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Planes, ships chase new leads in search for Malaysian jet
Published on Mar 27, 2014 2:51 AM
PERTH/KUALA LUMPUR (REUTERS) - New satellite images have revealed more than 100 objects in the southern Indian Ocean that could be debris from a Malaysian jetliner missing for 18 days, while planes scouring the frigid seas on Wednesday also reported seeing potential wreckage.
The latest sightings came as searchers stepped up efforts to find some trace of Malaysia Airlines flight MH370, thought to have crashed on March 8 with the loss of all 239 people aboard after flying thousands of miles off course.
"We have now had four separate satellite leads, from Australia, China and France, showing possible debris," Malaysian Acting Transport Minister Hishammuddin Hussein told a news conference. "It is now imperative that we link the debris to MH370." The latest images were captured by France-based Airbus Defence & Space on Monday and showed 122 potential objects in a 400-sq-km area of ocean, Hishammuddin said. The objects varied in size from one metre to 23 metres in length, he said.
Flight MH370 vanished from civilian radar screens less than an hour after taking off from Kuala Lumpur bound for Beijing, and investigators believe someone on the flight may have shut off the plane's communications systems.
Partial military radar tracking showed it turning west and recrossing the Malay Peninsula, apparently under the control of a skilled pilot.
Malaysia's air force has released few details of its radar tracking beyond saying the plane was last detected off the northwest coast heading towards India.
But the country's deputy defence minister, Abdul Rahim Bakri, told parliament that no action was taken when the unidentified plane was spotted because it was assumed it had been ordered to turn back, local media said.
"It was detected by our radar, but the turn back was by a non-hostile plane and we thought maybe it was at the directive of the control tower," he was quoted as saying.
Asked at the news conference whether air force radar operators thought the plane had been told to turn back by air traffic controllers, Hishammuddin, who is also defence minister, said he could not confirm it.
A dozen aircraft from Australia, the United States, New Zealand, China, Japan and South Korea were once more scouring the seas some 2,500 km southwest of Perth in the hunt for wreckage on Wednesday, after bad weather the previous day forced the suspension of the search.
"The crash zone is as close to nowhere as it's possible to be but it's closer to Australia than anywhere else," Australian Prime Minister Tony Abbott said, before leading the country's parliament in a moment's silence.
"A considerable amount of debris has been sighted in the area where the flight was last recorded. Bad weather and inaccessibility have so far prevented any of it from being recovered. But we are confident that it will be."
Wednesday's good weather was unlikely to last, in an area renowned among mariners for high winds and big waves. Recovery of wreckage could unlock clues about why and how the plane had diverted so far off course in one of aviation's most puzzling mysteries. Theories range from a hijacking to sabotage or a possible suicide by one of the pilots, but investigators have not ruled out technical problems.
Australia, China and France have all released satellite images over the past week showing possible debris in the same general area as the latest sighting, but no confirmed wreckage has been located.
An Australian navy ship returned to the area after being driven away by gale force winds and 20-metre waves on Tuesday, while a Chinese icebreaker and three Chinese navy vessels were also in the search zone.
Two Chinese ships were looking for a two-metre floating object spotted earlier in the day by an aircraft, China's state news agency Xinhua reported.
The United States has sent an undersea Navy drone and a high-tech black box detector which will be fitted to an Australian Defence vessel due in Perth in the coming days.
The so-called black boxes, the cockpit voice recorder and flight data recorder, record what happens during flight, but time is running out to pick up locator beacons that stop about a month after a crash due to limited battery life.
Malaysia said on Tuesday that the US "Towed Pinger Locator" would not arrive in the search area until April 5, which would give it only a few days to find the black box before the beacon battery would be expected to run out.
At the Pentagon, the US and British defence chiefs acknowledged the incident remained a mystery.
"On the terrorism question, I don't think at this point we can rule anything in or out. I think we have to continue to search," U.S. Defense Secretary Chuck Hagel said.
"Unless and until we recover the cockpit voice recorder, we will not know for certain," British Defence Secretary Philip Hammond said.
FBI Director James Comey said at a Washington hearing on Wednesday he expected his agency to finish an investigation of computer files related to the flight in the next day or two. He did not say what results he expected.


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Advanced Energy & Comfort Solutions has a proven record of excellence in designing and managing solar, energy efficiency and electrical projects in the Central Valley since 1991 when we installed our first solar project. We specialize in agricultural, commercial and residential solar. We also install or repair agricultural and commercial Electrical. No matter the size of your project, the experienced professionals at Advanced Energy & Comfort Solutions will plan, design, construct, and maintain your project.
We do not do solar leasing or use inexpensive panels. Solar leasing does not benefit the customer. There are multiple types of reasonable cost financing available. (See our Finance Page) We are a Christian based company and follow the Golden Rule in doing business. We treat you and your project as we would like to be treated. We use solar panels & inverters that have excellent reputations that we know will provide you with the best producing solar systems for our climate. Please see our Material, Quality Control & Warranty page for more information.
If you have multiple meters with your utility and it is on contiguous property that is owned, rented or leased by you, under new rules instigated this year, we can assist you in aggregation where one solar installation up to 1 MW in size can cover multiple meters. If you have several different locations, you can have an Aggregation Agreement at each where the solar is installed. Our prices are reasonable and we are ranchers ourselves, so we understand what needs to be done on your land. Our price is for a complete system, including upgrade of your service if necessary. With the value of wire and panels, you might also consider security fencing and cameras. We can also do this and include it in the price. Your time is valuable and we want to provide everything you need for one cost so there are no surprizes later. Also you get a 30% tax credit and can use accelerated depreciation. Plus this purchase like your other farm equipment is not taxed by the state of California but only by your local tax authority. We provide all the benefits when we present your system and contract price. Of course on tax matters, it is always best to consult your accountant and we advise you to take the numbers to him as everyone's taxsituation is different.
You'll Be Glad You Chose Us
Effective planning is crucial to the successful completion of any project. Before starting the project, our team of experts will first assess your goals. Then we provide you with an estimate and time-line for completion. From beginning to end you will be involved every step of the way as will the president and vice-president of the company.
Cost-Effective Services
Eliminate all the items on your to-do list by calling the experts at Advanced Energy & Comfort Solutions. You'll be glad you did. We have many years of experience and work hard to make sure the job is done right while saving you time, money, and aggravation. We'll be there whenever you need us.
Call us today to get your project underway. For quickest service on Solar, please have one years worth of electrical bills ready to present to us.
<>< <>< <>< <>< <>< <>< <>< <>< <>< <>< <>< <>< <>< <>< <>< <><
You can call the Office Monday through Saturday @ 559-222-7283 from 10 A.M. until 7 P.M.


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|Property type
|Minimum Stay
|7 nights
Panabode 3 bedroom/2 bath all cedar home with high ceilings, large wrap around deck sits on 4.5 acres of waterfront lawn, Cedars and Doug Firs in total privacy. There is also a deep dock and room for mooring. The heater is forced air. The house is cozy in minutes.
Plus there's a separate one bedroom/1 bath/kitchen/ living room cottage available on the property near the edge of the woods. Inquire if desired.
The sunsets from the West facing deck are utterly gorgeous and go on for hours in the summer months. The property is accessible by car, sail or power boat and seaplane and has a deep dock that accommodates a yacht or sailboat. There's power and water on the dock.
A marina is near by (but not too close:) with gas pump, restaurant and marine store --within walking distance. Every bedroom has a spectacular view. The stone fireplace services the living room on one side and goes through to the kitchen on the other. The house has wall to wall wool carpets, classy but comfortable furnishings, The house is 2 levels. And because its all cedar it smells wonderful. No smokers inside these walls. The cookware is all clad and new. All appliances one would expect are at the ready including a cappuccino maker and popcorn maker. Brand new stove top and convection oven + clay pot cooker, gas bar-b-que on the deck and propane provided, of course. There are games for kids and adults and a video library plus all star cable package from Starchoice. We've thought of a lot from excellent wireless broadband to croquet. But your suggestions are always welcome.
Special is an understatement. A Pacific Northwest Paradise.
Keywords: House
I was introduced to the island by close friends who live there and bought this pure cedar waterfront panabode house 22 years ago. It was built with loving care and superb taste by a lovely Dutch couple. I am the second owner. This is my soul place but because work takes me away from the island I rent it out sparingly. Everyone who has stayed has appreciated how special this place is.
Donna D purchased this house in 1990
There's nothing like it in all my travels. The house is tongue and groove cedar. No interior walls, Cedar is 8 ' thick and glows. And it smells wonderful. Its like being outside and inside at the same time.
The house and the cottage sit on 4.5 acres of private, blissful waterfront. And the deck with loungers and dining faces to the west with hours of summer sunsets.
Travel is my passion. This place was fabulously beautiful and lived up to its description and my expectations. It was totally private, had a view I'll never forget, a house with every comfort, great bed and linens and walks galore starting right out the front door. Take the beach walk at low tide and easy access as grass goes right down to it. I'm definitely coming back and bringing my sister and niece next time. There's also a cottage for an extended family get together. Wonderful!
We had a wonderful island, cottage experience! Peaceful sleeps, private balcony meals, wine on the dock with sunset views, sea kayaking to neighbouring islands, bike rides to the market, morning runs to the marine park...
We rented the main house -it was a great set-up for us! We had plenty of room in the house, enjoyed eating dinner on the deck, and reading on the dock: we loved the peaceful setting. My husband and two adult sons (20 and 22) and one friend boated over from Vancouver right to the dock- I took the ferry so we were able to explore the Gulf Islands by boat -and Galiano by boat and car. The location is great-we have family on Vancouver Island so we were even able to have day visitors -some who boated right to the dock and some who came by ferry! (including my Dad and Uncle) My one son and his friend loved biking and running right from the property. It is an easy walk to Montague Harbour -which has some groceries and a cafe. I highly recommend staying here for a relaxing get away- and try the Galiano Roasting Company coffee-mmmm!
What a beautiful place! The weather was perfect, everyone loved the house & harbor and the island itself. We rented both the main house and the small cottage. The wildlife & scenery was spectacular and we took advantage of many activities including chartering a boat (saw the orcas up near the north end of the island), a forest & beach hike with the nature conservatory guide, zodiac boat tour to Saturna for lunch, fishing for salmon in the ocean, kayaking in the harbor and a spa day at the Galiano Inn. Some of the creatures we saw from the dock & in the garden including river otters (family of five), minke, raccoons, red fox, deer, bald eagles, seals, hummingbirds, starfish & seastars. We didnt even have to leave the property to see these lovely animals! Oh and the sunsets were unbelievable.
We hope to go back soon, and often!
A perfect place to relax while enjoying the many wonderful attributes of a wonderful island. The house is lovely and rests in the midst of a small patch of forrest with several old growth trees that were 600 years old! The ocean views were stunning. Thank you for a wonderful time.
Came with my girlfriend on her sailboat from Vancouver along with her brother and his boyfriend.
Had a blast! It rained 2 out of 7 days but there's a fab huge fireplace set in stone wall that opens up to living room on one side and kitchen on the other and adequate stereo system. Paradise in more ways than one:)
We celebrated my husband's birthday here this year. Our 2 grown children joined us for 3 of our 7 days. It was perfect. My son loves to cook and the kitchen was suited to a gourmet. My daughter loves to hike and wonderful trails begin ( so she said) at the end of the drive. The view from the living room, deck and master bedroom was just as the photo showed it. My husband and I had never stayed in a panabode (all cedar) house. It was lovely to be surrounded by pure healthy beautiful cedar. We hope to come back next year and make this a birthday ritual.
On the island, The Madrona del Mar Spa is dedicated and focused on healing and elevating your spirit. They have a unique array of over 75 spa treatments and exciting packages to choose from!: http://www.galianoinn.com/site/spa.html
|Rate Period
|Weekend Night
|Monthly *
My Standard Rate
7 night minimum stay
|Property Damage Protection
|Clean 6 + $300 5 & under
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.


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PILOT MOUNTAIN — Northwestern Regional Library's annual Awards Reception and Photography Exhibit will be held on Tuesday at the Charles H. Stone Library in Pilot Mountain, starting at 6:30 p.m.
A free photography workshop on developing a personal photograph style will be conducted prior to the awards reception by award-winning photographer Hobart Jones. The workshop will begin at 5:30 p.m.
Both the workshop and the reception are free and open to the public. Heavy hors d'oeuvres will be served at the awards reception.
Amateur and professional photographers who reside in Surry, Stokes, Alleghany and Yadkin counties were eligible to enter photographs.
At last year's reception, a large crowd of people were in attendance, with standing-room-only, many of whom were there to support a friend, family member, or loved one who had entered photographs in the contest.
The photo contest is in its eighth year and has grown each year, Regional Library Supervisor John Sherif said.
Many of the photographs entered in the contest will be part of a traveling exhibit that will go to each library in the system. Each library will exhibit photos from their county.
The People's Choice Award last year went to Carolyn Choate of Mount Airy for her photograph "Chief Atop Raven Knob."
Award winners will receive cash prizes, funded from the entry fees for the contest.
Last year's award winners included:
• Youth 5-8, Color: first place to John Kessler of Yadkin County; second place to Carter Alley of Elkin; honorable mention for Carolina Alley of Elkin
• Youth 9-12, Color: first, second place and honorable mention to Christian William of Alleghany County; third place to Ian Dollyhite of Pilot Mountain
• Youth 13-17, Black and White: first place to William Wesley Robinson of Pilot Mountain; second place to Emily Brim of Mount Airy
• Youth 13-17, Color: first place to Whitney Pardue of Elkin; second place to Abby Shepherd of Pilot Mountain; third place and honorable mention to William Wesley Robinson of Pilot Mountain
• Adult, Digitally Altered: first place to Misty Hagwood of Mount Airy; second place to James R. Norris of Alleghany County; third place to Jim Drum
• Adult, Black and White: first place to Danny Redd of Alleghany County; second place to Josie Grogan of Pilot Mountain; third place to Casey Grogan of Pilot Mountain; honorable mentions to Connie Duffey and Rich Miller of Pilot Mountain
• Adult, Color: first place and third place to Dave Lineback of Alleghany County; second place to Raybern Mitchell of Mount Airy
Honorable mentions for the adult color category were awarded to:
• Yadkin County: Angela Reaves, Darrell Ring
• Pilot Mountain: Jonathan Bass of Pilot Mountain, two for Randy Keith, two for Greg Dollyhite, Bob Pantano, two for Richard Hill
• Mount Airy: Rodney McDaniel, Linda Humphrey, Dana Cochran, Carolyn Choate
• Elkin: Judy Conrad, Bonni Hicks, Leonard Reynolds
• Alleghany County: Tina Duffey, two for Dave Lineback, two for Sandra Walker, three for Sheila Carico, James R. Norris, Carol Norris, two for Danny Redd, two for Rich Miller, T.J. Worthington
• Danbury: Rodger L. Sheffer Jr.
• King: Ann Nichols
• Northwestern Regional Library Headquarters honorable mention went to Marie Simonelli.
• Best in Show was awarded to Dave Linebeck for "Shirt Factory Door."
• People's Choice award was presented to Carolyn Choate for "Chief Atop Raven Knob.
For more information, contact the Charles H. Stone Memorial Library in Pilot Mountain at 368-2370, the Northwestern Regional Library at 835-4894 or the website at www.nwrl.org.
Reach Jessica Johnson at 719-1933 and on Twitter @MountAiryJess.


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Training Courses
Lorraine Hennessy,Head of TrainingWe have been a provider of Welfare to Work and Welfare Rights training services for over 20 years. We offer six individual training courses as part of our standard Training Calendar services. These courses are available to INOU member organisations, statutory and non-statutory agencies and other groups.
The courses are:
- Welfare Rights - FETAC Level 6 (2 days a month over 6 months)
- Train the Trainer - FETAC Level 6 (2 days a month over 6 months)
- Information, Advice and Advocacy - FETAC Level 6
- Welfare to Work (2 day course)
- Introduction to Social Welfare (1 Day course)
- Delivering a quality information service to the unemployed (1 day course)
- Building Futures (1 year course with major award in Community Development)
On Request Training Services
We also provide a comprehensive range of 'on-request' training services on Welfare to Work issues. Our Tutors can tailor the content and presentation of courses to meet the needs of individual groups or organisations. On-request training sessions are delivered flexibly and are designed around the training needs of the participants and the requesting organisation.
INOU Training Room
The INOU is registered with FETAC (Further Education and Training Awards Council) to offer programmes leading to FETAC awards in the National Framework of Qualifications and has agreed its quality assurance procedures with FETAC.
Achieving a FETAC qualification provided by the INOU will create greater awareness and knowledge around welfare rights issues and the impact of unemployment on a person's ability to participate fully and equally in society
As a FETAC accredited provider we are in the unique position of having a wealth of knowledge and experience of welfare rights issues whilst also being able to provide relevant training in this area.


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Victoria's Secret Angels Adriana Lima, Marissa Miller, Heidi Klum, and Alessandra Ambrosio hit the runway this weekend for the annual Victoria's Secret fashion show.
Check out the flicks of supermodels below. You can thank us later.
Tags: Adriana Lima » Alessandra Ambrosio » Heidi Klum » Marisa Miller » Victoria's Secret
Copyright ©2015, Interactive One . All Rights Reserved Powered by WordPress.com VIP


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Multi-market Collusion with Territorial Allocation
This paper develops a supergame model of collusion between price-setting oligopolists located in different markets separated by trade costs. The firms produce a homogenous good and sustain collusion based on territorial allocation of markets. We first show, in a more general framework than some earlier literature, that a reduction in trade costs can paradoxically increase the sustainability of collusion. Then we prove a new paradox where the scope for collusion may be enhanced by an increase in the number of firms. We discuss several implications for trade and antitrust policy in this context.
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|41 pages
|Date of creation:
|Oct 2012
|Date of revision:
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| Postal:
Phone: (011) 27667005
Fax: (011) 27667159
Web page: http://www.cdedse.org/
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- K. C. Fung, 1991. "Collusive Intra-industry Trade," Canadian Journal of Economics, Canadian Economics Association, vol. 24(2), pages 391-404, May.
- Jeanine Thal, 2005.
"Optimal Collusion under Cost Asymmetry,"
Working Papers
2005-36, Centre de Recherche en Economie et Statistique.
- Jeanine Miklós-Thal, 2011. "Optimal collusion under cost asymmetry," Economic Theory, Springer, vol. 46(1), pages 99-125, January.
- Miklos-Thal, Jeanine, 2008. "Optimal Collusion under Cost Asymmetry," MPRA Paper 11044, University Library of Munich, Germany.
- Philipp J. H. Schröder, 2007.
"Cartel Stability and Economic Integration,"
Review of International Economics,
Wiley Blackwell, vol. 15(2), pages 313-320, 05.
- Philipp J. H. Schröder, 2004. "Cartel Stability and Economic Integration," Discussion Papers of DIW Berlin 432, DIW Berlin, German Institute for Economic Research.
- Bhattacharjea, Aditya, 1995. "Strategic tariffs and endogenous market structures: Trade and industrial policies under imperfect competition," Journal of Development Economics, Elsevier, vol. 47(2), pages 287-312, August.
- B. Douglas Bernheim & Michael D. Whinston, 1990. "Multimarket Contact and Collusive Behavior," RAND Journal of Economics, The RAND Corporation, vol. 21(1), pages 1-26, Spring.
- Stephen Davies & Matthew Olczak & Heather Coles, 2007. "Tacit Collusion, Firm Asymmetries and Numbers: Evidence from EC Merger Cases," Working Papers 07-7, Centre for Competition Policy, University of East Anglia.
- John Gross & William L. Holahan, 2003. "Credible Collusion in Spatially Separated Markets," International Economic Review, Department of Economics, University of Pennsylvania and Osaka University Institute of Social and Economic Research Association, vol. 44(1), pages 299-312, February.
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|May 25, 2013, 07:40 AM
Best Mac for a writer who also does photography
Hi I am looking at getting my first Mac.
I currently use an ancient 15" ASUS laptop as my main computer but it is well past its use by date and I need to upgrade. I use my computer for writing and also some photo editing. Not big on games but I'm an occasional user. I'm not sure if I should get a MacBook Air (with 8 MB RAM)or 13 inch Retina Pro (love the colour sats)and maybe get an external monitor. Or to go for something like an a 15" MacBook Pro or even an iMac and use my iPad for portability. Cost is an issue as it is with us all. I generally will be using the computer for research and writing but also for photo editing (want to develop (haha ) this area more). I've been perusing the forums and everything has it's pluses and minuses. iMacs can overheat badly, MBAs are minimalist in the ports they offer, retina MBP look awful on any browser but Safari - and they cost more than an Air. So I don't know where to start.
I'm wondering if people who use the 13" screen all day get eye strain.I find my current 15" screen is a good size but the cost of the 15" retina MBP (with the specs I'd like) is a bit out of my reach.
|May 25, 2013, 07:53 AM
Eye strain will be dependent on how close you stay to the screen in my experience. Clarity is awesome on retinas. I would think either 13" MBA or rMBP would be good, but rMBP offers more in terms of power. If weight is more important for portability, MBA wins.
iMac is awesome but not mobile and you are replacing a laptop so...
iPad may not do all you want while mobile but worth considering if iMac/iPad can work for you.
I would still go rMBP for what you described and because you are into photography (editing) and for light gaming 13" should be ok. Heavy gaming would need dedicated GPU and that means 15" retina or iMac.
|May 25, 2013, 08:58 AM
Any of the machines is going to handle your workload: it's more a question, as you imply, of what you can afford, versus the features you get.
2012 MacMini, 2.6GHz i7, 16Gb RAM, Fusion Drive | 2012 MacBook Pro, 16Gb RAM, 480 Gb SSD |
2009 MacBook | 2006 iMac | 2003 G3 iBook | Beige G3 | PowerMac 7600 | Mac IIsi |
|May 25, 2013, 09:28 AM
If you need portability, Macbook Air is very nice.
The combination of a 13" laptop and an external monitor at home is a good one. I think many folks get tired of toting a 15" laptop around.
A new version of the Macbook Air is reported to be _very_ close to release. You might want to hold off through mid-June if you're considering the MBAir model.
Other thoughts:
If portability isn't a concern, the Mac Mini could be a good choice.
The best _value_ in Mac laptops is still the "regular" (non-retina) MacBook Pro. If cost is a consideration .
|May 25, 2013, 02:18 PM
Laptop vs. desktop may be a matter of where you do the bulk of your work. If you only have to be portable 10% of the time, why handicap yourself for the other 90%? If the split is closer to 50/50, perhaps a laptop plus large monitor in the office is a better way to go.
I find screen size is an important factor for productivity. The bigger the desktop, the more stuff I can spread around (eg. browser window side-by-side with word processor window, rather than switching back and forth). After that, it's a matter of how big the actual objects are at that given resolution - at native resolution the 13" MacBook Pro Retina can fit a touch more than a 27" iMac, but will your eyes be up to it? I suggest you try both on for size.
Native resolution:
11" MacBook Air - 1366 x 762
13" MacBook Air - 1440 x 900
13" MacBook Pro - 1280 x 800
15" MacBook Pro - 1440 x 900
13" MacBook Pro Retina - 2560 x 1600
15" MacBook Pro Retina - 2880 x 1800
21" iMac - 1920 x 1080
27" iMac - 2560 x 1440
I've never been happy when I've had a laptop as my primary machine - the 13"-15" screen is just too small for day-to-day work, plus, there's some neck strain due to the low position of the display (keyboard at comfortable height means display at uncomfortable height). I've been doing well with 21" iMacs for a while now, though my next will probably be a 27".
I happen to use the iMac-plus-iPad solution (iPad plus wireless keyboard). Yeah, carrying a MacBook Air rather than iPad-plus-keyboard is a neater lightweight solution, but the keyboard only comes out when I need to type in reasonable quantities and at reasonable speed, so it often stays behind or remains in my backpack.
I stopped using a laptop a few months after I got my iPad - it just wasn't worth the extra weight and bulk. Plus, it was easier to fit my iPad and keyboard on an airline tray table. Finally, the iPad is a far more practical thing to carry around on a daily basis - I don't go anywhere without it, while I'd be far less likely to carry either an Air or Pro around wherever I go. A tool you have with you at all times is more likely to be used than a tool you leave behind. I now write whenever words come into my mind.
But workflow can be a strong determining factor. I don't have to produce finished documents or photos when I'm in the field. Formatting and editing can wait until I get back to the office. The Notes app has been enough for my writing needs, and iPad photography apps have been more than enough for a quick down-and-dirty edit.
But if I had a more nomadic lifestyle (reporting for extended periods from the field), I'd probably want a full-strength MacBook with full-strength apps waiting for me at the end of the day (iPad plus MacBook under those circumstances).
|May 27, 2013, 01:17 PM
I echo what ApfelKuchen said. My wife uses an iMac+iPad while I use a 15" MBP + iPad. We're both happy with our respective choices. When at home I use my MBP in clamshell mode with a 23" cinema display and full size keyboard. The 15" gives me adequate screen real estate when on the road. I've tried the 13" in stores but find them just a little too small for my needs. For a number of years I used 14" IBM/Lenovo laptops and while the 14" was ok, I always wanted just a little more screen space.
15" MBP (late 2011), iPhone 5
iPad Air, ATV3 Mac Pro 3,1
|May 28, 2013, 02:10 AM
Thanks . This gives me food for thought. I had a play with a friend's MacBook Air today and it was lovely and light but I am used to a bit bigger screen on my old ASUS and it feels a little fragile (although I am sure it's not). Still I could get a good monitor as I suggested above. At the moment I do about 90% of my writing at my desk at home but I would like to be more mobile. I could foresee it being 80:20 or even 70:30 if I had more mobility. I haven't loved using my iPad with keyboard but maybe I need to try using it a bit more. I had another look at the iMac and the thing that worries me most is its height. It's not adjustable and I'm not that tall. I get neck and shoulder issues if I'm not careful. I have also heard of them overheating if you use them all day... Is that a big problem? I'm not a huge fan of their keyboard either but I could always plug in an alternative wireless keyboard. in reality I think I'd like a 15" Retina Pro - I like the feel and look of it - but that is probably overkill given my needs.
I am going to hold off until mid June now and see what's going to be launched or upgraded. My old workhorse is struggling though so I hope it makes it til then . Any other advice you guys could give me would be most appreciated
|May 28, 2013, 02:38 AM
You could go for the iMac with the wall mount option so you can select the correct height. I use mine on a desk all day without issue (I'm 5'8"). I guess it depends on your desk set up. To be honest if you have been using a laptop I think you will find it to be a good experience.
In your op you mentioned concerns over the iMac overheating. Not sure where you got this information, but I can tell you doing photography work and writing will not cause it to get warm.
The mini with a good external monitor is another good option. If your serious about photography get an Eizo or NEC monitor. A cheap monitor with a small colour space and poor resolution won't do you any favours.
iMac 21.5 2013, iPhone 6 Plus, iPad 2/4/Air Nikon D750/D7100 70-200 2.8/24-70 2.8/14-24 2.8/105 Macro 2.8/10.5 Fish eye 2.8
|May 28, 2013, 09:30 AM
Re the iMac - I saw the base model on special in a shop yesterday. About $50 off. But just with the 1Tb hard drive. I was thinking that if I went the iMac I would pay extra for the fusion drive. Is it worth it? Or best to go for the SSD?
It was the 21" that I was looking at...
If I got a monitor I'd want it to be really good for text as well as pictures. A friend told me they bought one that was good for pics but text was fuzzy.
Last edited by Writergirl7; May 28, 2013 at 09:37 AM.
|May 28, 2013, 09:47 AM
I have the fusion drive and it is quick compared to my old PC. I guess it depends on what you are used to. If you do go the 21" route I would think about upgrading the Ram as its not user accessible unless you are very brave! Especially if you plan on keeping it a few years.
The Dell Ultra sharp aren't bad but I find they don't have such a good range and depth of colour. Especially noticeable with black's etc. That said if you go for a Eizo the CG range are the ones to look at if your budget can squeeze it. The NEC Spectraview are also good, but in Europe a Spectraview is not the same as in the USA so you might get away with a PA series.
iMac 21.5 2013, iPhone 6 Plus, iPad 2/4/Air Nikon D750/D7100 70-200 2.8/24-70 2.8/14-24 2.8/105 Macro 2.8/10.5 Fish eye 2.8
|May 28, 2013, 04:40 PM
Shopping for a display for color correction and possibly retouch/post work you're basically looking for certain things. You want the display to look good when set to lower brightness levels. If it looks terrible when set to a measurable 120cd/m2 or so, it's not going to be a good purchase. You don't want to see crushed shadows or weird compressed midtone values. You want wide viewing angles so the image doesn't shift slightly if you move your head a little or look different at the edges compared to the center because of this. You want the best uniformity possible much more than anything else. Otherwise it's just difficult to interpret things. Your eye can't really separate this when it's subtle, and when it's a severe it's a major distraction.
Ideally you want one of the systems that uses hardware LUTs rather than having to deal with ICC profiles for calibration. ICC profiles are a terrible way of dealing with it. They try to tune the display behavior by adusting the signal level instructions sent to the graphics card. It's an extremely indirect method. Eizo/NEC tend to not use that part of the profile. It's set to linear and accounted for via lookup table supported by the display itself. The ICC profile still provides a gamut description for color management purposes. It just doesn't try to stabilize the display hardware by way of its profile. Hopefully that makes sense.
Assuming no external display and you want a notebook (mini + NEC isn't a bad option) I like the retina macbook pros. The viewing angles are better than the old ones. They're still somewhat reflective, which is annoying, but it's less of an issue if you don't have too much stray light. IPS displays generally tend to be more pleasing than TN panels too. If you're dealing a lot with photography, 16GB of ram can be more comfortable than 8. I'm not sure if you're in the US, but even though it's limited to 8GB, the refurbished retina macbook pros are $1600, so close to the price of a new 13" rmbp. The only specs that really matter most of the time for your proposed uses are ram, storage, and display quality (also maybe ports for additional storage).
Blah my posts always get far too long.
world's largest manufacturer of tin foil hats, none of that aluminum foil crap.
|May 28, 2013, 09:20 PM
That sounds very complex. Might lean towards the iMac and look to get a refurbished MBA down the track so I can run the same writing software... So many options!
|May 28, 2013, 10:08 PM
world's largest manufacturer of tin foil hats, none of that aluminum foil crap.
|May 28, 2013, 11:33 PM
What about the fusion drive or substituting a SSD for the 1Tb HD? Is it worth it?
My current laptop has a glossy display so that shouldn't be a big problem.
|May 29, 2013, 11:08 AM
I am torn between various similar choices myself. The MBPr is really nice and really expensive. The screen is of course small for heavy photo use. It is portable, but not so much as an iPad. Later you could hook it up to a future retina monitor, but that is sure an expensive way to go.
And it has the best screen actually available now (speaking consumer grade).
The iMac has an improved screen and is powerful. You could buy one to use for a year or so until the inevitable and superior retina model comes out. Not a cheap solution, but certainly fairly simple. People will marvel at its thin edges...
The cheapest and most flexible plan is to get a Mini and the best affordable monitor. It is not necessary to go "pro" with the monitor. Later you can update the monitor, assuming today's Mini would run a 20+" retina monitor (I don't know).
And of course use an iPad would be so nice for couch and travel.
My recommendations are in descending order, but the expense is in ascending order.
|May 29, 2013, 03:50 PM
world's largest manufacturer of tin foil hats, none of that aluminum foil crap.
|May 29, 2013, 06:52 PM
SSD-only is still an expensive option GB for GB. You could end up outgrowing it fast. Fusion is the way I'll be going with my next iMac. It's a tad slower than SSD-only, but way faster than HD-only, and I get a whole lot more storage for the money. No matter what, I run an external drive for Time Machine backup.
As to the height of an iMac... I'm over 6', so for optimal height I should raise it up a few inches. Since there's no overhead lighting (no reflection issues), I can tilt the monitor up and it's perfectly comfortable. I can't imagine it being too low if you're 5' 5", and it doesn't seem likely it'd be too high. At least, if the rest of your desk/chair combination is also at the correct height ergonomically.
|May 30, 2013, 12:14 AM
I think maybe my desk is a little higher than average but I use a keyboard tray which provides relatively good ergonomics. Would most newer external HHDs be good for back up or do you need a special type? Time Machine is an automatic process you set up? Pardon my ignorance but I've been a long term PC girl.
It seems all of this it boils down to whether I want portability or functionality most. And because I want both the decision is difficult. From what you guys have said if I want portability either an Air with maxed out RAM or a 13" Pro is best - along with a good external monitor. It will be okay for photo editing but not as good as if I go for an iMac desktop (ideally with increased RAM plus a fusion drive) and use my I pad or get a refurb Air for when I'm away from my desk.
|May 30, 2013, 05:53 AM
Time machine is something you set up and, depending on how much is on your computer, the first backup can take quite a while. I have a partitioned external drive with TM on half and Carbon Copy Cloner on the other half ... The latter is a fully bootable backup whereas TM apparently doesn't back up a bootable system.
I use an Air, hooked up to a Dell U2412 monitor when at my desk, for writing and many other things. In both cases the screens are okay for text but only just okay and way short of retina sharpness. The Air is a great computer though. Handles music processing, my not very demanding photo editing, the only time I hear the fans is when converting video formats.
I love writing in different locations at home as well as away, and the Air is great for that. The ipad4 is even better because of the retina screen, I do a lot of writing on that and pick it up via Dropbox on the Air when I want to do more with it, in Scrivener.
Late 2013 13" MBPr 8/256. iPhone5 white 32. iPad Air2 gold 64/LTE, iPad Air white/32/wifi.
|May 31, 2013, 10:53 PM
A few more questions. If I decided to spend a little more cash do you think a MBA with Thunderbolt Display would be better for my needs than a) the above with a good generic display & b) the iMac plus my iPad (and later getting a second hand 11""MBA)? Are all TBDs 27"? I'm now torn between the idea of having one computer with great display/ one hard drive/ one lot of licensing cf two computers/ good for back up but pain to synchronise, and need two licenses for some stuff etc?
|Jun 2, 2013, 07:42 AM
The place where the thunderbolt display shines is as a docking station. I've never put in enough hours on one to render a decent verdict, but a lot of people like them. In the $1000~ range I tend to like NEC as far as absolute quality. The thunderbolt display may be updated soon with the same screen treatment the imac received. The effect would be lower reflectivity.
world's largest manufacturer of tin foil hats, none of that aluminum foil crap.
|Jun 2, 2013, 07:50 AM
The macbook air + external monitor is a good idea considering how affordable LCD monitors are now.
I'm a casual user, so the 13" was just right for me. But for a writer and photographer, I would get the 15" if you will be doing a lot of your work away from your desk. Otherwise the 13" plugged into a 19-20" external monitor at home will be a good setup for you.
|Jun 2, 2013, 08:06 AM
15" non-retina
I have had my 15" 2008 MacBook Pro for 5 months now. It is replacing a 13" MacBook also from 2008. There is literally nothing I would change on this computer to make it better. Having a retina screen does not seem like a good option at this point. The extra GPU power needed to drive the display isn't always there with the integrated gpu, and the only content that can really take advantage of those extra pixels anyway is the built-in apple apps, the few that decide to update their apps to support retina, and hi-res photos. If you get the non-retina 15, then everything simply works, without having worry. If i could afford a newer model, then by all means i would have an i7 and a new GeForce, but the 2.4Core2Duo and 9600m are plenty for video editing, regular tasks, and gaming (except if you want to run new games on high graphics. You can just turn those down a bit.) But a new 15 has even better performance. Once you get into the realm of macbook pro, the only thing holding it back from being faster is your internet speed, and the fact that you probably don't have an SSD. Having google fiber and a fat SSD in a MBP 15 would be the best solution for personal computing thus far in the world.
Macs: Late '08 MacBook Pro Alu/2.4 GHz/4GB DDR3/320GB 7200rpm Seagate/256MB 9600M GT/10.8.x
PowerMac G4 1.46GHz/1.5GB/320GB 7200rpm/128MB ATI Radeon 9800 Pro/10.5.8
|Jun 19, 2013, 09:11 PM
My choice - for the moment
When I went shopping the writer in me won. I was seduced by the 11" MBA. It's light, beautiful and very easy to type on. I'm still awaiting delivery - I ordered the I.3GHz with 250GB ssd and 8 GB RAM. The idea was to get a machine that would help me write - that was my main need. I am seriously thinking of getting an iMac to keep it company later on - or is that just overkill? In the meantime I will look out for a reasonable budget monitor I think. Something thay will run well off the Air and give pretty good colour reproduction but not costing more than about $300-350.
|Jun 21, 2013, 11:19 AM
Not overkill if you can afford it
The 2012 iMacs have much less glare than my 2010. I've slowly come around to them and will probably stay with them despite my hemming and hawing to the contrary.
Since you are also into Photography, I think the iMac/MBA is a nice combination for what you wish to do.
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text:
Justin Timberlake is having a big week. Not only did he release his second studio album of the year (The 20/20 Experience part 2) but he has a new thriller with Ben Affleck debuting on Friday. Runner, Runner represents his return to theaters following his role in the overlooked Trouble With The Curve. The fact that he has two diverse projects coming out only reinforces that fact that Timberlake has had quite a varied career (and personal life). With that, here's your JT guide covering everything from 'A to Z.'
A: Academy Awards
No, Timberlake has never been nominated for an Oscar. Though, the days are coming when that might be the case (see: I). In 1999, N SYNC recorded "Music Of My Heart" with Gloria Estefan for the film of the same name. The song, penned by Diane Warren, was later nominated for Best Original Song putting the boy band on the Oscar stage for just one night. And probably making them the only boy band ever allowed near such a ceremony.
B: Biel, Jessica
While there have been numerous women (Britney Spears, see: C) in JT's life, only one has locked him down. Though, the relationship has come with its share of rumors (she's the doormat) and turmoils (he's cheating on her). After dating for four years, the two broke up in 2011. But later that year JT got down on one knee. Their 2012 wedding came with its own drama: N SYNC (see: K) wasn't invited to the ceremony, the People cover left wondering who was the real star of the relationship.
C: "Cry Me A River"
After a very public three year relationship, JT and Britney Spears parted ways in 2002. The reason why is still subject of speculation. Was it because Spears cheated on Timberlake with dance choreographer Wade Robson? No one knows for sure. What we do know is that after an argument with his ex, Timberlake channeled his anger into recording "Cry Me A River." "Told me you loved me, why did you leave me all alone / Now you tell me you need me when you call me on the phone," Justin sings on the record. Burn.
D: "Dick In A Box"
Listed at number nine on Vulture's Millennial 100 list, "Dick In A Box" helped not only define a generation but JT's life outside of music. Saturday Night Live's digital short brilliantly parodied '90s R&B while poking fun at the singer himself. It also launched Timberlake, the omnipresent entertainer. Fans could find him in movies, hosting Saturday Night Live (five times), at concerts or hanging out on late night talk shows (see: Q). It's also worth mentioning that his SNL career has been as nearly successful as his singing. He's been nominated for three Emmy Awards and taken home one as host of the show.
E: Edison
Long before The Social Network, JT was making the transition from singer to singer/actor. His first major role was the Morgan Freeman straight-to-DVD flick, Edison, about corrupt cops. He quickly followed up the flop with Alpha Dog, Southland Tales and Black Snake Moan. While the last two were seen as slight missteps, neither would derail his acting career, which finally saw him in the Oscar-winning David Fincher movie as Sean Parker.


text:
COLUMBIA CITY — School board member Tim Bloom peered over his glasses Monday night at a collection of local teachers who attended the regular meeting of the Whitley County Consolidated School Corporation's Board of School Trustees.
The board, minus two members, was preparing to vote on the elimination of 27 positions from the school system's payroll, a move sparked by a slumping economy and the subsequent budget shortfalls at public schools statewide.
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Ball spent 47 days in Europe last summer. She traveled throughout Germany, Poland, Austria, Switzerland and the Netherlands, visiting places where Frank spent her life, and learning Jewish history dating back to the 12th century. She deepened her experiences there to further understand what makes the Holocaust such a tragic human event, as well as a distinct genocide.
Spring cleanup dates in Columbia City are June 11 and 18, according to clerk-treasurer Rosie Coyle. West side cleanup will be on June 11 and east side on June 18.
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"We coulda wupped them this year," said Bob Addison, the master chef behind their previous successes.
COLUMBIA CITY — Excessive wetness is an issue that's been at the top of the Columbia City "to-do" list for years.
Last week the town's Board of Works and Safety heard a presentation from GAI Consultants about a study to help combat at least some of the town's drainage problem.
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"It's a pretty large watershed area."
COLUMBIA CITY — When contaminated soil was found under railroad tracks in Columbia City earlier this year, it brought to a grinding halt, progress on a sewer extension project planned by the city for some time.
The bureaucratic red tape involved with contacting the Indiana Department of Environmental Management was relatively painless, as government-involved procedures go.
It's the delay and its effect on the contractor hired to do some of the work that may prove the most costly to local government entities.
COLUMBIA CITY — Auditors offices around the area are being inundated with phone calls lately because of taxpayer confusion surrounding the word "Homestead."
"We had 94 calls in two days," said Whitley County Auditor Jen McGuire.
She said that number is low because it's just the number of callers who talked to one employee in her office.
"He kept track," she said.
The confusion — the elimination of a three-year homestead credit on Indiana tax bills.
INDIANAPOLIS — After months of penny-pinching and budget-hacking, and following a heated debate where proposed state legislation drew the ire of Indiana teachers, Gov. Mitch Daniels and both branches of the state government are declaring some good news on the education front.
In what state lawmakers say is a rare joint announcement, House Speaker Brian Bosma R-Indianapolis along with Senate President Pro Tempore David Long R-Fort Wayne and Daniels announced their support for an additional $150 million investment in K-12 education, emphasizing early learning


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Bright Green Leaf Wall Art
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Using a leafy design fabric print you can take plain ordinary wall art and turn it into a great focal point in any room. This is a great spring decorative piece. Find this project and many more low-cost decorating ideas in the great decor in a flash without a lot of cash eBook from Dow.
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- STYROFOAM™ Brand Foam:
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- Use poster adhesive to attach to wall. Or, glue sawtooth hangers to back of each panel; for additional hold, insert and glue two straight pins through holes in sawtooth picture hanger; let dry.
- To change the look, simply remove pins and repeat Steps 1 and 2 with new fabric.
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