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Your baby deserves the best.
Your child's safety is our greatest concern. Stork Craft strives to exceed your expectations in the areas of safety, performance, usability and style. All Stork Craft products meet or exceed domestic and international regulatory standards for juvenile furniture safety and performance, and are carefully designed to mitigate the risks of potential hazards to your child.
- Easy assembly using cam-lock construction
- Steel drawer glides with safety stop
- Round wooden pulls
- Durable non-toxic finish
- Tipping restraint included
- JPMA Certified
- Assembly Instructions
Furnished Over 1 Million Homes Since 1997...
I was very satisfied with One Way Furniture Service. I have referred them to many friends, family, and customers. Thank you. Kathy A. Eisele, Boston, MA
Product Review - Stork Craft - Beatrice - Kids Dresser
Furniture Brand
Weight & Size
Reference - Sku: 03581-744 - Stork Craft - Beatrice - Kids Dresser by Stork Craft


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Actor Jason Schwartzman Needs to Stop It With That Face – The Daily Swoon
Jason Schwartzman is such a classic case of the ugly ducking thing — he started out as a goofy and very talented young actor with comically massive eyebrows and emerged as a glorious swan, who's still very talented, but super sexy now.
I have probably the hugest crush in my life on Jason Schwartzman. He has amazing hair, beautiful eyebrows, a cute mole, and he's an incredible actor who's been in some of my favorite movies and worked with my favorite directors. Check him out in 'Moonrise Kingdom,' 'Marie Antoinette,' 'I Heart Huckabees,' or on the now-canceled HBO series 'Bored to Death.'
He's handsome, dark, clever, and sweet, and he comes from very good stock: His mother is 'Rocky' actress Talia Shire (aka ADRIANNNNNN), his uncle is legendary director Francis Ford Coppola, and his cousin is the beautiful and amazing director Sofia Coppola.
But before you go talking about nepotism, Schwartzman is honest-to-goodness talented, and while he's worked with his family, he's also proven that he doesn't need to drop their name to get anywhere. Oh, and he sings in his own band, Coconut Records — they haven't released an album in a few years, which makes me sad, but it's super good music, so check it out.
Last week, Schwartzman guest starred on 'Parks and Recreation,' and I've included this amazing GIF below, which made me totally melt. His face! It's like a sexy puppy!

subset: commoncrawl


text:
Floor Plans
Apartment Amenities and Features
- Gourmet kitchens with solid wood maple cabinetry and pantry
- Stainless steel on black Whirlpool appliances
- Granite countertops
- Refrigerators with ice maker
- Dishwashers
- Gas range
- Microwaves
- Garbage disposals
- Ceramic tile in the kitchen
- Stainless steel kitchen sinks with pull-out spray head faucets
- Full size washer and gas dryers
- Marble bathroom countertops
- Ample closet space
- Gas Fireplaces *
- Double sink vanities *
- Oval bathtubs *
- Built-in computer niches *
- Round bistro-style counters with built-in wine racks in kitchens *
- 17-foot vaulted ceilings in the top floor lofts *
* Available in select apartments only
Pet Policy
Our apartment community welcomes pets. Additional fees and breed restrictions may apply. Please call for details.


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Director of Counseling Program
Deb Bilzing joined Lakeland as the Director of the Master of Arts in Counseling Program in January 2010. She holds a doctorate from Edgewood College and is a veteran educational leader, having been recognized for her leadership and contributions to the field through awards such as the Association of Computer-Based Systems for Career Information Award, the Wisconsin School Counseling Association's (WSCA) Leadership Award, and the WSCA Outstanding Achievement Award. Currently Bilzing is the vice-president elect for postsecondary education on the Wisconsin School Counseling Executive Board.
As the MAC program director, Bilzing supports students, faculty, and staff in the areas of community counseling, school counseling, and higher education counseling, which are offered in all seven of Kellett School locations.


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JupiterJones wrote:I will only butt in to recommend that anyone considering drafting a mission statement should read this blog post from Guy Kawasaki:
http://blog.guykawasaki.com/2006/01/man ... z1mNxcoi1H
VictoriaF wrote:That's fair. How about this?
Bogleheads mission: Investing in low-cost index funds.
a2z wrote:I feel a need to reframe my need. When I talk about money with friends, family and cohorts I usually refer them to Bogleheads.org with ease and expedience. And they often have a puzzled behind-the-lens-glare in their eyes. What are you trying to sell me or what cult do you want me to join? It's then that I could really use a definitive, accurate and honest descriptive Bogleheads 30 second "elevator speech."
a2z wrote:Here's the latest revised and condensed version of my original Bogleheads mission/elevator speech. Thanks to all who have contributed, and a special note of thanks to Peter Foley for suggesting a close version of my "hopefully" final draft.
Bogleheads...support individuals to make intelligent, prudent and independent decisions as they manage their money.
"Bogleheads help investors make intelligent, independent decisions." is even more to the point.mptfan wrote:Bogleheads help people make intelligent, independent decisions about managing money.
Return to "Investing - Theory, News & General"
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How? I have so many friends buying into this crap. It was really picking up steam when it was a viral internet sensation, but now that the mainstream media is whoring it out I have noticed people back tracking downplaying their expectations. It reminds me of that Documentary "Doomsday Cult" or the Y2K scare.
It is such a perfect example of how people think wrong and look for evidence in the wrong places and ignore anything contrary to what they want.
I guess what bothers me is non religious people wanting the world to end.
Anyone else know any people buying into this load?


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Need for Speed The Run PC Patch Available Now and it comes with a Special Bonus!
January 31, 2012
It's been a long time in the making but today we're very happy to say that Need for Speed The Run patch is now available. Here are some highlights of the updates in the patch, but for a full list visit the Need for Speed "Downloads" page:
- 30 FPS cap is disabled when v-sync is set to OFF in advanced display settings
- Tweaked reset behavior for a number of tracks in The Run where resets seemed too close to the main race route
- When players go off track, they will be reset back onto the track instead of at the last checkpoint. Crashes will still result in a reset to the last checkpoint.
- Added Quick Match option from multiplayer menu
– Players now have the option to mute VOIP of other players in multiplayer sessions
– Reduced unrealistic behaviors when multiplayer opponents drive off-road or collide with world objects
- Autolog Friends now displays whether a friend is online, joinable or offline in player badge
We're also very excited to announce that not only will PC players get all the updates; they'll also get all the Signature Edition Booster Pack cars! You'll be able to take on The Run, challenge Series or your friends in multiplayer with these signature rides:
- Puppet Chevy El Camino SS
- Fatlace Nissan Skyline 2000GT-R
- Venom Nissan 370Z
- Scoundrel Subaru Impreza WRX STi
- Victory BMW M3 Sport Evolution
- Nicolas Mazda RX-7
- Mega Nissan GT-R (R35)
- Falken Porsche 911 GT3
- Conroy Ford GT
To get the patch simply login to Origin on your PC and it will automatically download / install the patch.
Let us know what you think of the patch by either leaving a comment on the Need for Speed Facebook wall or tweet us @NeedforSpeed.


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|Heather Vale, RN is the May 2012 DAISY Award Recipient
Congratulations to Heather Vale, RN who is the May 2012 Daisy Award Recipient. Heather joined ACH in 2002 and has been an RN in the Radiology Department since 2011. The DAISY Award is presented monthly to an All Children's Hospital Nurse who has provided extraordinary service to our patients. Heather was nominated by a parent who wrote:
My son was required to have an extensive MRI after he came up positive on a scan for bilateral pheochromocytoma. He already had two positive urine screens for high catecholamines and positive blood work from plasma. I knew he was very ill, but I couldn't get anyone to take me seriously. All Children's Hospital was the first to believe me.
This is where Heather came to my rescue. I was told it was dangerous to put him under sedation due to his unpredictable blood pressure and heart rate. The test was going to take an hour and a half, which turned into five hours. It felt like it took forever. When it was over and I was able to see him I thought I was ok, but then I had a meltdown in front of him. Even though her 12-hour shift was over, Heather asked me to take a walk with her (since I was scaring my son). She spent at least 45 minutes with me. She helped me pull myself together and was so nice to me. I truly felt she cared. I can't tell you how much she helped me that evening. She went way beyond the call of duty and I will never forget her. She had no concerns that she was working well past the end of her shift. She could have just left and went home without another thought of me and my son, but she didn't. Please pass my gratitude to her and let her know how much it meant to me.
Heather's department director added:
Heather is compassionate, knowledgeable, dedicated and diligent with respect to her responsibilities," said MaryAnn Bruton, Director of Imaging Services. "This not only applies to her job, but it's a way of life for her. Heather is always willing to go the extra mile to ensure that her patients are cared for appropriately and are comfortable undergoing their procedure. She helps parents to make sure they are confident about the care their children receive. She is an excellent team player and a good nurse. Her coworkers think the world of her. Radiology is proud and fortunate to have her represent us."
Heather, thank you for your service excellence to All Children's Hospital and your continued passion to pursue perfection.


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The HMS Education Department offers workshops and special events for children and adolescents on Saturdays, during the holidays and during the summer vacation. These activities take place at the Art Center and at the various museums, and include a range of year-round creative experiences.
For information about birthdays at the museums press here
For information about upcoming activities press here
For further information, please contact:
Phone: 04-9115944
Fax: 04-9115946


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Aramark Leisure
Company Culture
Core Values
Social Responsibility
Green Thread
Community Involvement
Sustainable Practices
Guest Service Standards
Partnership Solutions
Food and Beverage
Lodges and Resorts
Cultural Attractions
Conference Centers
Alaska Parks and Destinations-AK
Asilomar Conference Grounds-CA
Lake Powell Resorts & Marinas-AZ-UT
Mesa Verde National Park-CO
Olympic Peninsula-WA
Togwotee Mountain Lodge-WY
Zephyr Cove Resort & Marina-NV
Central Reservations Call Center
We're sorry... the page you're looking for is no longer available - or you entered a URL that's no longer active. The good news is, you're one click away from discovering something thrilling about Aramark!
Maybe you'd like to check out About Us.
Perhaps you're curious about our Services.
Then again, you might just want to see it all from the beginning on our homepage.


text:
Osteoporosis Center - Stamford, CT
Stamford Internist Doctors for Osteoporosis
Type of Physician: Internist
What is a Internist?
A certification by the Board of Internal Medicine; practitioners provide long-term, comprehensive care in the office and the hospital, managing both common illnesses and complex problems for adolescents, adults, and the elderly. General internists are trained in primary care internal medicine, which incorporates an understanding of disease prevention, wellness, substance abuse, mental health and treatment of problems of the eyes, ears, skin, nervous system and reproductive organs. All internists are trained in the subspecialty areas of internal medicine including emergency internal medicine and critical care. Internists consult with surgeons when surgical management is indicated, and often act as consultants to other specialists.
Specialty: Internal Medicine
Common Name:
Internist Doctors in Stamford *
Executive Hlth Exams Internatnl
Prime Care Medical Group
Prime Care Medical Group
Prime Care Medical Group
Optimus Healthcare
Radhika Jasthi MD
Optimus Healthcare
Prime Care Medical Group
Primecare Medical Associates
Primecare Medical Associates
Primecare Medical Associates
Primecare Medical Associates
Primecare Medical Associates
Connecticut Renaissance Inc
Medical Associates of Stamford
Stamford Primary Care
Alfonse M Campo MD
Stamford VA Primary Care Clinic
Shoreline Medical LLP
Stamford Primary Care
Shoreline Medical LLP
Stamford VA Primary Care Clinic
Tulin Koparan MD
Shoreline Medical LLP
Medical Associates of Stamford
Shoreline Medical LLP
Medical Associates of Stamford
Shoreline Medical LLP
Medical Associates of Stamford
Internal Medicine Stamford PC
Stamford Primary Care
Medical Associates of Stamford
Medical Associates of Stamford
Stamford Hospitalists
Stamford Hospitalists
Stamford Hospital Surgery
Stamford Hospitalists
Robert Shapiro MD
Tully Health Center Diagnostic
Anna L Shender DO
Fusco & Neuberger Mds
Brian B Hennessy MD
CT Healthcare Consultants PC
Fusco & Neuberger Mds
Northeast Medical Group
Opticmical Health Medical
Vipulkumar P Bhalodiya MD
Primecare Medical Stamford Hlth
Primecare Medical Stamford Hlth
Greenwich Medical Spa
Old Greenwich Medical Group
Old Greenwich Medical Group
Old Greenwich Medical Group
Old Greenwich Medical Group
Marietta S Vergara MD
Bruce R Baron MD PC
Riverside Internal Medicine
Greenwich Walk In Medical
Jurij Savyckyj MD
Associated Internists of Darien
Moore & Lebowitz MDs
Associated Internists of Darien
Moore & Lebowitz MDs
Immediate Medical Care Center
Jeffrey H Weinberger MD
Walsh Brunetti LLC
Walsh Brunetti LLC
Walsh Brunetti LLC
Walsh Brunetti LLC
Ellen N Wolfson MD
Ronald M Levine MD
Ronald M Levine MD
Fairfield County Personal Medcn
Fairfield County Personal Medcn
Personal Physicians Of CT
William J Giesen MD
Internal Medicine Associates
Internal Medicine Associates
Internal Medicine Associates
Internal Medicine Associates
Internal Medicine Associates
Internal Medicine Associates
The Medical Office
Jennifer G Jose MD LLC
The Medical Office
Christopher M Edelmann MD PC
Soundview Medical
Greenwich Hospital Hospitalist
Robert M Stark MD
Greenwich Rheumatology
James S Borges MD
Greenwich Rheumatology
Occupational Health
True Care Medical Practice
Sunil Rana MD PC
Peak Wellness
Soundview Medical Associates
Soundview Medical Associates
Soundview Medical Associates
Greenwich Hospital Cancer Inst
Stamford, Connecticut
Osteoporosis facts
Other Related Osteoporosis Articles
Emergency Contact for Stamford
Nearby Stamford Hospitals *
Stamford Hospital
Greenwich Hospital
Norwalk Hospital
Silver Hill Hospital
St Vincent's Hosp Westchester
New York Presbyterian Hospital
Burke Rehabilitation Hospital
White Plains Hospital
St Vincent's Behavioral Health
Glen Cove Hospital
Blythedale Children's Hospital
Huntington Hospital
Northern Westchester Hospital
Westchester Medical Center
Bedford Hills Correctional
Four Winds Hospital
VA Medical Center-Northport
Sound Shore Medical Center
St John's Riverside Dobbs Ferry
Syosset Hospital
Phelps Memorial Hospital Center
Lawrence Hospital Center
Mount Vernon Hospital
Saint Francis Hospital
Sing Sing Correctional Facility
St John's Riverside Hosp-Andrus
Plainview Hospital
Montefiore Wakefield Campus
Sagamore Children's Psych Ctr
St Johns Riverside Parkcare
Nyack Hospital
Saint Josephs Medical Center
St Vincent's Medical Center
North Shore University Hospital
Jacobi Medical Center
Montefiore Medical Center
St Catherine Of Siena Med Ctr
Bronx Psychiatric Center
Calvary Hospital
Montefiore Medical Center
New York City Children's Center
North Central Bronx Hospital
Bridgeport Hospital
Greater Bridgeport Mental Hlth
Pilgrim Psychiatric Center
Winthrop University Hospital
Cohen Children's Medical Center
Rockland Psychiatric Center
Long Island Jewish Medical Ctr
St Mary's Healthcare Children
Nassau University Medical Ctr
Rockland Children's Psychiatric
Zucker Hillside Hospital
James J Peters VA Medical Ctr
Saint Joseph Hospital
St Barnabas Hospital
Allen Hospital
Queens Children's Psychiatric
Stony Brook University Med Ctr
Creedmoor Psychiatric Center
Bronx Lebanon Hospital Center
Putnam Hospital Center
VA Hudson Valley Healthcare
Bronx Lebanon Hospital Center
Englewood Hospital Medical Ctr
Hudson Valley Hospital Center
Flushing Hosp Med Ctr
Danbury Hospital
Helen Hayes Hospital
Columbia Presbyterian Med Ctr
Morgan Stanley Children's Hosp
Mercy Medical Center
New York State Psychiatric Inst
Lincoln Med/Mntl Hlth Ctr
New York Hospital Medical Ctr
*Provider Directory Terms of Use:
The WebMD 'Provider Directory' is provided by WebMD for use by the general public as a quick reference of information about Providers. The Provider Directory is not intended as a tool for verifying the credentials, qualifications, or abilities of any Provider contained therein. Inclusion in the Provider Directory does not imply recommendation or endorsement nor does omission in the Provider Directory imply WebMD disapproval.


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Dicor Ready-to-Use Rubber Roof Cleaner, 32 oz. spray
Catalog Item # 34837
Reg $17.99
Ask a Question
Directions: Spray-on wet roof, scrub with soft to medium bristle brush and rinse off. Allow roof to dry and follow with Dicor Roof-Gard Rubber Roof Protectant.
Technical Specs
Weight: 1.8 lbs.
Manufacturer: Dicor Corp
Mfg Part #: RP-RC320S
Related Items
Dicor Ready-to-Use Rubber Roof Cleaner, 32 oz. spray: Customer Reviews
Camper's Choice Rating
Reviewed by 1 customers
Ask a Question
Ask your question today to get answers from other owners of this product and Camping World staff members. If you have a question for customer service such as pricing, shipping or order information please do not submit your question through this form. Please contact Customer Service.


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Book your room at The LA Hotel Downtown
Please enter your travel dates.
High-rise haven in LA's financial core
LA's financial district
Located in Los Angeles' financial district, The LA Hotel Downtown is linked to downtown Los Angeles businesses via a second-floor walkway, and is 1 mile from LA Live, NOKIA Theatre, and Staples Center.
LA swank
The enormous lobby of The LA Hotel Downtown impresses with original art and crystal chandeliers. The gift shop stocks fine jewelry and luggage as well as last minute essential items.
High-rise views
Guestrooms have floor-to-ceiling windows offering skyline views. Amenities include premium bedding, large work desks, louvered closets, marble baths, and wireless Internet access.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
In L.A.'s financial district, this hotel is adjacent to the World Trade Center and is 1 mile (1.6 kilometers) from the Los Angeles Convention & Exhibition Center.
Beyond a stylish entry lined with limos and valets, this hotel features a huge, art-filled lobby with formal sitting area and step-down lounge. There is also a 24-hour business center with fax/copy machines and computers with high-speed Internet access available for a surcharge. Wireless Internet access is available throughout the hotel for an additional cost.
The Back Porch offers informal garden dining, and the lobby lounge is open all day and evening. A ballroom, banquet facilities, and event catering are on site for special occasions and weddings.
Guests can enjoy the outdoor swimming pool and the complimentary 24-hour fitness center with cardio machines and free weights. Helpful staff can assist with tour/ticket information and luggage storage.
- Tours/ticket assistance
- Dry cleaning/laundry service
- Wedding services
- Elevator/lift
- Computer station
- Luggage storage
- Concierge services
- Fitness facilities
- Bar/lounge
- Business center
- Conference space
- ATM/banking
- Number of floors - 14
- Gift shops or newsstand
- Multilingual staff
- Total number of rooms - 469
- Safe-deposit box at front desk
- Number of restaurants - 2
- Smoke-free property
- Outdoor pool
- Breakfast available (surcharge)
- WiFi (surcharge)
- Valet parking (surcharge)
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Rollaway/extra beds available
- Refrigerator (on request)
- Cribs/infant beds (complimentary)
Available in all rooms: Wireless internet access ( 9.95 USD per day )
Available in some public areas: Wireless internet access ( 9.95 USD per day )
Valet parking (surcharge)
Room Amenities
- Free cribs/infant beds
- Air conditioning
- Pay movies
- Hypo-allergenic bedding available
- Bathrobes
- Free toiletries
- Premium bedding
- Hair dryer
- Iron/ironing board
- In-room safe
- Coffee/tea maker
- Refrigerator (on request)
- Cable TV service
- Desk
- Rollaway/extra beds available
- Flat-panel TV
- Room service (limited hours)
- WiFi (surcharge)
Where to Eat
The Back Porch: This informal garden room, adjacent to the lobby, serves breakfast, lunch, dinner, and offers outdoor dining.
Lobby Lounge: Breakfast, light meals, and cocktails are served at this centrally located lounge.
Nearby Things to Do
The LA Hotel Downtown offers a palm-fringed outdoor pool and sundeck. Guests have complimentary access to the 24-hour fitness room, which offers cardio equipment and free weights.
The YMCA is connected to the hotel via a pedestrian bridge, and offers tennis, racquetball, basketball, fitness classes, and swimming (surcharge).
The recreational activities listed below are available either on site or near the hotel; fees may apply.
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessibility equipment for the deaf
- Accessible bathroom
- Accessible path of travel
- Accessible parking
- In-room accessibility
- Roll-in shower
Hotel Policies
Check-in time starts at 3 PM
Minimum check-in age is 21
Check-out time is noon
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! Children under 18 years old stay free when using existing bedding.
- Rollaway/extra beds are available.
- Free cribs (infant beds)!
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Fee for buffet breakfast: USD 28 per person (approximately)
- Fee for in-room wireless Internet: USD 9.95 per day (rates may vary)
- Fee for wireless Internet in public areas: USD 9.95 per day (rates may vary)
- Valet parking fee: USD 35 per day
We should mention
Children 18 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.


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Fox News
Several major solar panel companies have been issued subpoenas as part of a federal investigation into whether they overcharged for their work in order to squeeze more stimulus money out of taxpayers. The investigation was revealed earlier this year by one of the subjects in the probe, California-based SolarCity. Shortly before going public last week, the company disclosed in an SEC statement that it "and other companies with significant market share" -- as well as others "related to the solar industry" -- had received subpoenas from the Treasury Department's Office of the Inspector General. The SEC statement did not reveal what other companies are being scrutinized. But The Washington Post reported that SunRun and Sungevity have also received Treasury subpoenas. The investigation fo
Read the Full Article


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Top Definition
A town located in central oregon. Very dangerous place. Alot of gangs drugs violence robbery. you can get killed by wearing wrong colors for example red or blue. Chances of a new person survival is at about 0%.
Person 1 lets go into madras. Person 2 your crazy I dony wanna get shot
додав that one guy from madras 14 Серпень 2012
1 more definition
A shithole cesspool of a town located in central oregon, where everybody fucks everybody regardless of gender or relation. A methamphetamine mecca on the west coast.
Your acting like your from madras.
додав gruntsunn 31 Липень 2008


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Hey guys!
The new major event, Wintersday, is heading our way! What do we know of it up till now and what has changed in the last couple of weeks? Find out this and more in my first video in this new video-series.
Please let me know what you think of this new format, and if you would watch more of it (if it was available)
Leave comments preferable in YouTube itself, but here on the forum is fine too.
Dont forget to subscribe, like and comment to help me gain more views!
If the embedd doesn't work, please check it out here:


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Hearts to hearts, though miles apart, with gifts of love, happiness we impart!
Gifts! They bring instant smiles, don't they? Why, then, would you let distance stand as a hindrance? Geographical distance is nothing but a number! Bridge the gap with our unique collection and send gifts to India from USA with ease. Understanding just how much your loved ones miss your presence on special occasions, we have come up with a portal so they feel you close to them regardless of where you are. Let them know you still care and that they are always remembered. Just tell us what, when, and how, and we'll do the rest for you.
© GiftaGift 2015. All Rights Reserved.


text:
For potential or existing investors. Find out more about our range of funds and investment trusts, including prices, information and tools.
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text:
The Sports Network
By Scott Haynes, Senior College Football Editor
GAME NOTES: The top-ranked Alabama Crimson Tide head down the homestretch with
a three-game homestand to close out the regular season, starting with this
weekend's clash with the 15th-ranked Texas A&M Aggies in Tuscaloosa.
Nick Saban's squad had run over the competition on the docket until last
weekend, when the defending national champions had to come from behind to
preserve their perfect season with a 21-17 victory over then fifth-ranked LSU.
The victory moved Alabama to 9-0 on the season and 6-0 in league play. A win
in this game would secure the SEC West for the Crimson Tide.
Kevin Sumlin's first season in College Station has been highly successful, as
the Aggies are 7-2 overall. The team's first foray into the SEC has been
equally satisfying at 4-2, two full games behind the Tide. Texas A&M was in
Starkville last weekend, where the Aggies posted an impressive 38-13 romp over
Mississippi State.
This marks just the fifth meeting between these two teams and first since
1988. Alabama holds a 3-1 series advantage, although this game represents
A&M's first-ever trip to Tuscaloosa.
The Aggies have excelled on the offensive side of the football this season,
ranking fourth nationally in scoring (44.7 ppg), fifth in total offense (559.6
ypg), while placing 19th in passing (308.2 ypg) and 10th in rushing (251.3
ypg). In all, the team has scored 49 offensive touchdowns (32 rushing, 17
passing). Texas A&M is on pace to break the SEC record for total offense per
game set by Florida in 1995 (534.4 ypg).
Redshirt freshman quarterback Johnny Manziel has been outstanding in his first
season under center and could mean more to his team than any player in the
country. Manziel has completed 66.6 percent of his passes, for 2,527 yards and
16 TDs, but means almost as much to his team for his rushing exploits, closing
in on 1,000 yards (922), with 15 more scores.
Other offensive players of note include Mike Evans (56 receptions, 802 yards,
two TDs) and Ryan Swope (45 receptions, 641 yards, five TDs) and tailback Ben
Malena (637 yards, 6.6 ypc, six TDs).
The offense as a whole has evolved and Sumlin is pleased with that.
"We are certainly a different team than we were week one. Ten weeks later we
better be, especially with a young quarterback. We certainly have more offense
at our disposal now than we had against Florida. It's just growth, number one.
Number two, it is the comfort level and Johnny being able to handle it. Just
because you put up a play, you better have some answers for it. Defenses in
this league are pretty complex. It's not necessarily what you think you can
handle as a coach but what your players can handle. In year one, ten weeks in,
I think we've progressed pretty well."
While Texas A&M has allowed its offense to lead the way, the defense has
showed flashes of strong play.
Rush end Damontre Moore has been a one-man wrecking crew, leading A&M in
tackles (69), while ranking among the nation's best in TFLs (19.0) and sacks
(11.5). Middle linebacker Jonathan Stewart is second on the team in tackles
The A&M offense has received plenty of attention, but Saban knows that the
Aggies are a complete team.
"Their defense is really good - they are very aggressive, they do a lot of
different things, they run a lot of pressures. They are very, very aggressive
in terms of loading the box and they are going to stop the run at just about
all costs. They are just very, very aggressive. They have good players and
have been pretty successful doing the things that they do."
Alabama quarterback AJ McCarron showed his ability to be clutch when needed,
leading a pair of scoring drives in two-minute drills at the ends of both
halves, resulting in two touchdowns and a come-from-behind victory in Baton
McCarron has orchestrated an offensive attack that averages an impressive
424.7 yards per game, with great balance. The Crimson Tide are putting up over
200 yards per game both on the ground (209.0) and through the air (215.7).
A cool and collected signal-caller, McCarron has completed 66.7 percent of his
throws, for 1,849 yards, with 19 TDs and no interceptions. Amari Cooper (32
receptions, 472 yards, five TDs) has been the primary target in the passing
game, but everything is set up by the run.
Tailbacks T.J. Yeldon (725 yards, 7.0 ypc, seven TDs) and Eddie Lacey (679
yards, 5.7 ypc, eight TDs) have been an effective tandem on the ground.
The nation's best defense resides in Tuscaloosa, with Alabama ranking first in
scoring defense (9.1 ppg) and second in both rush defense (66.3 ypg) and total
defense (228.9 ypg).
The squad is paced by an impressive linebacking corps, headlined by C.J.
Mosley (team-high 69 tackles, three sacks, two interceptions and one fumble
recovery). Fellow linebackers Trey DePriest (44 tackles) and Nico Johnson (40
tackles, two INTs, two fumble recoveries) have made their share of plays as
The Aggies have been able to put up big numbers this season, but doing so
against the Crimson Tide is a different story entirely. Manziel may be able to
make a few plays here and there, but probably not enough to prevent a double-
digit win by the hometown team.
Sports Network Predicted Outcome: Alabama 31, Texas A&M 20


text:
Dynasty: Season 3 - Volume 2 DVD
$27.99Add to Wish list
You Save: $7.99 22% off
- Additional Details
- Format: DVD
- Rating: Not Rated
- Number of Discs: 3
- Run Time: 570 Minutes
- Aspect Ratio: Fullscreen
- Studio: Paramount
- DVD Release Date: October 21, 2008
- Subtitles: English, Spanish
- Audio:
ENGLISH: Dolby Digital Mono [CC]
SPANISH: Dolby Digital Mono
- Cast: Heather Locklear, Joan Collins, Linda Evans, Pamela Sue Martin, John Forsythe, Jack Coleman, Al Corley, John James
- Genre: TV Series
- Color: Color
- Release Date: 1983
Dynasty Season 3 Vol. 2 is part of the hugely popular primetime soap opera that follows the exploits of the Carringtons and Colbys, two ''oil rich'' family dynasties in Denver, CO, as they accrue and manipulate power and wealth.
Actors: Geoffrey Scott, Ashley Mutrux, Janet Brandt, William Beckley, Christopher Allport
Format: Box set, Color, Dubbed, DVD-video, Full Screen, Subtitled, NTSC
Language: English
Number of discs: 3
Rating: Not Rated
Studio: Paramount
DVD Release Date: October 21, 2008
Shop for Dynasty Season 3 Vol. 2 where hair is big, makeup is perfect and shoulder pads help make the women larger than life.


text:
Vandals slit tires on up to 160 cars in Marysville
Jennifer Buchanan / The Herald
Tom Miller talks to a neighbor outside his Marysville home Friday afternoon. Almost all of the cars on 99th Place NE, including three in Miller's driveway, had their tires slashed.
Jennifer Buchanan / The Herald
A truck on 97th Street NE has flat tires and a Jeep behind it is up on jacks because of multiple flats as well.
Jennifer Buchanan / The Herald
Laura Harding reads from the owners manual while her husband, Chad, gets ready to fix a flat tire on their car Friday afternoon. The Hardings, who live on 52nd Drive NE in Marysville, got about a block from their house before realizing they had a flat tire and had to return to their house to fix it.
Eleven of the 12 tires on his family's three cars were slashed overnight. He spent the morning buying new ones for two of the cars.
Vandals didn't just choose Miller. He had plenty of company.
Seventeen of the 20 cars in his cul de sac had tires punctured by something sharp jabbed into a sidewall.
The Marysville Police Department received reports of 132 slit tires, "but we know there are more out there than that," Cmdr. Robb Lamoureux said.
By Friday afternoon, police were estimating up to 160 vehicles had tires slashed the night before. Many were in front of homes straddling 100th Street NE near 55th Avenue NE.
Calls started pouring into the police department after 5 a.m.
The first came from a caller who reported hearing a hissing sound from his neighbor's driveway.
For some families, the vandalism will put a crimp in their holiday budgets.
"It's really put us in a bind," Miller said. "There won't be Christmas presents this year now, but we'll live through it."
Miller figures by the time he's done he'll have spent thousands of dollars replacing all the destroyed tires.
Miller has little choice but to spend the money. He needs to get to work and his wife uses a second car to transport their special needs daughter, 13, to appointments.
Erik Mangold left his home early Friday morning to find a business card from the police department on the windshield of his car, which had flattened rear tires.
His family's sport utility vehicle appeared to have been spared.
Mangold, his wife and two young boys, 3 and 1, all piled into the SUV so he could get to his job in Bothell. On I-5, he soon realized something was amiss.
"My tires got super squirrely," he said.
He got off at the 41st Street exit and found a service station where he was able to get some soapy water to pour over his tires. The sidewalls had been slashed and bubbles formed over the punctures, revealing the slow leaks. He has good insurance, but he'll still be out $500 for both vehicles.
Mangold said he is frustrated he has to pay for new tires, but is angrier that someone put his family in danger.
"They have nothing to gain from this," he said. "This is pointless. It's absolutely pointless."
Both Miller and Mangold suspect that the vandalism likely is the work of young people.
"I do hope they get caught," Mangold said. "If it is kids, I feel really bad for their parents." Restitution could reach tens of thousands of dollars.
Lamoureux said Friday that police are asking for people to call 360-363-8300 with tips. Detectives also are asking people with home security cameras to review video footage to see if any suspicious activity was captured.
Eric Stevick: 425-339-3446, email@example.com
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text:
By Barbara A. Besteni, Contributing writer
In "Defending Your Life," a 1991 film starring Meryl Streep and Albert Brooks, the protagonists died and went to Judgment City, a kind of way station where it was decided if they would go on to the next level or go back for another life on Earth.
In one scene, the two are seen gorging on platefuls of food. One of the perks of being dead, apparently, is eating all you want and not gaining an ounce. But you don't have to wait until the afterlife to eat more and weigh less.
You can start by making a few simple changes to your diet.
The concept of eating more to weigh less has been popular since the publication of "Eat More, Weigh Less: Dr. Dean Ornish's Program for Losing Weight Safely While Eating Abundantly."If you're attracted because you think you'll be able to scarf down giant slices of cake, refined carbohydrates, ice cream and pints of beer, get ready for the bad news. That's not what this diet is about.
Eat More, But Not Everything
While the catchy name is sure to have attracted hundreds in search of diet Nirvana, the reality is that the foods you eat and quality of the food is what helps you keep off the pounds, and the only magic formula for losing weight is to eat fewer calories than you burn.
The body is a great mathematician. And it will forgive the 500 calories in your grande mocha choco-latte only if you find a way to burn them before the end of the day or you deprive yourself of something else to make up for the calories.
"I've been following this diet since I was in high school," says Linda Hopkins, a 5-foot-3-inch South Florida woman who looks more like one of her students than a 52-year-old math teacher. At 110 pounds, Hopkins says she can still fit into her prom dress.
Good habits start early, she says.
"When I was growing up, there was always an abundance of fruits and vegetables at home," she says. "Don't get me wrong, I had my share of Twinkies and Good Humor ice cream. But because I was feeding my body good quality foods, it let me get away with the occasional bad sugar and white flour."
Eat More, Weigh Less Diet Basics
Ornish's diet is simple: Eat large quantities of complex carbohydrates, such as whole grain breads and cereals, and the fruits and vegetables that Hopkins ate so much of as a child. Because the diet is high in fiber and volume, you fill up quickly. The high fiber also keeps you fuller longer.
But perhaps the most important key to the success of this diet is that it requires you to eat complex carbohydrates, not ones with simple, processed sugars found in white bread, rice and pasta. Complex carbs don't cause spikes in your blood sugar levels. Because your blood sugar stays relatively stable, you won't find yourself battling sugar cravings an hour after a meal.
The diet recommends eating the following whenever you're hungry: Beans and legumes, any kind of fruit, vegetables or whole grain foods.
In each case, you need to read labels to make sure a food doesn't contain added sugar, or sugar disguised as fructose.
Stop When You're Full
You can eat as much of these foods as you want, as long as you stop when you are full, the diet says.
Stopping when you're full is a key component. However, fans of the diet say this is easier to do than on most diets.
"I think it's because you get to eat a lot of filling foods on this diet. A bowl of whole wheat pasta and a salad fills me up pretty quickly. And the fact (that) the whole wheat pasta won't send my blood sugar crashing after an hour is an added bonus. I stay full a lot longer," Hopkins says.
If you can't eliminate dairy from your diet entirely, you should choose the nonfat variety, but consume it in moderation.
What? No Protein?
The strictest part of the diet is the recommendation that you avoid meat, fish, chicken, anything containing fat or oil, nuts, alcohol and commercially prepared foods with more than 2 grams of fat.
Hopkins, however, says this is one part of the diet she doesn't follow. She doesn't feel guilty about it.
"If I had to live without a filet mignon and a glass or two of merlot once in a while, life would not be worth living," she laughs. "Guilt leads to deprivation, which eventually leads to throwing your hands up and forgetting all about healthy eating."
Critics Want More Balance
Critics of the diet agree with Hopkins. Restricting meat, dairy products and fat, they say, deprives your body of nutrients. If, however, you choose to follow the diet to the letter, nutritionists suggest you take vitamin or mineral supplements to make up where the diet lacks. Always check with your doctor first.
"I love this diet because it's not really a diet. It's just a smart and nutritious way to eat. I get to eat real food that tastes good, not something that comes pre-packaged in a box or a can," Hopkins says.
By making small changes to the diet and not depriving herself of the foods she loves, Hopkins has done what nutritionists say is the key to eating well and staying at a healthy weight: You can eat more and weigh less, just as long as you eat more of the right foods at least most of the time.


text:
At the ASPCA, we see many feline victims of High Rise Syndrome each year, but perhaps none so lucky as three-year-old Pereque, who miraculously survived a fall from a five-story apartment building window right onto a spiked fence.
After his fall, Pereque's pet parent rushed him to the ASPCA Animal Hospital, where he underwent surgery with ASPCA Director of Surgery Dr. J'mai Gayle that same day.
Pereque sustained only non-life threatening injuries—in fact, he didn't even have a broken bone! Fortunately for Pereque, the spikes on the fence just missed his femoral artery, and all of his major organs were unharmed.
ASPCA Veterinarian Dr. Laura Niestat also treated Pereque during his stay at AAH and released him to his pet parent three days later.
"I believe he ultimately did quite well," Dr. Gayle says.
We're so glad we were able to treat this resilient kitty when he needed us most!
For more information about our emergency veterinary care services, please visit the ASPCA Animal Hospital online.
Thank you very much ASPCA. If it was not for the love and care from both of our part and your part, Pereque would not have made it. He is an amazing cat and a very special one. He was very strong and at all times cooperated with everyone that crossed his way. This is definitely a memorable experience and we are very happy that he is recovering like a super cat :))). Love love love
How does one fall 5-stories and land on a spiked fence survive? Amazing little cat...so glad he was rushed to animal hospital immediately and that he is doing so well!
I seriously doubt this cat 'fell' - is anyone investigating this incident? The area is known for animal abandonment, abuse and 'falls'
Poor cat
Almost to lucky butvicsm glad she or he survived
And at the person who says it was a "fall"
They wouldn't have rushed it to the hispital
Yes, Pereque is VERY lucky to have survived the five-story fall, and I am so happy that he is doing well; however, if I were the vet, I would seriously consider not letting that owner have the cat back. How/why was Pereque allowed to be in a window or wherever where this could happen?? This is totally unacceptable, and, in my opinion, the cat should be placed in a loving, responsible home rather than with the owner who let him fall. What a shame animals have to suffer at the hands of the irresponsibility of humans. This truly makes me sick!!!
I'm so glad Perequa is doing so well. Thank goodness for the ASPCA and their great vets!
I love the darling, soft collar Pereque is wearing. SO MUCH BETTER and one I've never seen. Someone deserves an award for that design!
Pereque's guardian kitty angel was flying with him.
Incredible that so little damage was done.
Just goes to show you miracles happen.
To those of you who seem to be so lackidaisical about an animal almost dying due to a fall that could have been prevented: you don't know that this wasn't an act of negligence, either, now do you?? To me, this is inexcusable and irresponsible, and that's that, no matter how one looks at it. I certainly DO NOT look for the worst in every situation, but this is a lapse of judgement that almost cost this cat his life. If that happened to be a child, would you be so "chilled out" about it?? I hope you don't have children or companion animals. Seems to me someone else is being judgemental here besides the ones who don't think this is a big deal. I have my opinion and you have yours, so let it go at that!!


text:
13c., from Old English dufan "to dive, duck, sink" (intransitive, class II strong verb; past tense deaf, past participle dofen) and dyfan "to dip, submerge" (weak, transitive), from Proto-Germanic *dubijanan, from PIE *dheub- (see deep). Past tense dove is a later formation, perhaps on analogy of drive/drove. Related: Diving. Dive bomber attested by 1939.
c.1700, from dive (v.). Sense of "disreputable bar" is first recorded American English 1871, perhaps because they were usually in basements, and going into one was both a literal and figurative "diving."
: They fixed it so that he'd dive in the fourthRelated Terms
[origin of first sense uncertain; perhaps fr the notion that one could dive into a disreputable cellar haunt (called a diving bell in an 1883 glossary) and lose oneself among lowlifes and criminals; perhaps a shortening of divan, ''a smoking and gaming room,'' a usage popular in London in the mid-and late 19th century; the places were so called because they were furnished with divans, ''lounges,'' the name ultimately fr Turkish]


text:
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EG Smith Original Bootsocks
Also found in:
♠ Men's Socks ♠ EG Smith ♠ Knee Highs ♠ Cotton ♠ Midcalves ♠ Made in the USA ♠ Burning Man ♠ Bootsocks ♠ Scrunchy Socks ♠ Non-Constrictive ♠ Larger Feet ♠ Sport Socks ♠ Burning Man
Well, not exactly the original boot sock, but pretty darn close. Thick cotton slouchable midcalves that are durable and comfy. Made in the USA!
Label says sock size 9-13.
Top and calf stretch on these is about the same 16.5 inches as the early original boot socks. Ankles stretch to about 14 inches.
About 14.5 inches from heel to top of cuff, unstretched.
Additional Info: Just like the original Originals, these socks say "Love, Eric" on the foot.
Fiber Content:
98% cotton, 2% nylon
Hand or machine wash cold, line dry.
Label: EG Smith
I love boot socks but these are way way too big. Do you offer a mostly cotton boot sock that comes in a medium or womens size. I bought a couple of these socks and have tried to shrink them but no luck
I wear a size 7 would they work for me??
why are these socks so different from every other pair of "original boot socks" i ever bought from you? and how do i return them?
You guys are always so amazing about sharing how different items fit on different bodies (which helps ensure happy customers!). I love your selection, and my friends always know that a Sock Dreams gift certificate never goes amiss as a gift in this household!
~ Andi S.


text:
The thought of losing Nick Matics for the season and perhaps beyond quickly surfaced in Southwest soccer coach John Sweeney's mind when the Stallions opened practice last year.
"I was hoping to play Nick in the middle last year because he had recovered from the previous season's knee injury and I expected big things from him, but that first day he went down with an injury and I thought he was done," Sweeney said. "But the next day he showed up with a pair of gloves and said, 'I can play in the goal' … and once he got there, he enjoyed it."
Fast forward to the present and Matics is a key contributor as the senior starting goalkeeper for Southwest (10-2-2), which plays hosts to Spring Creek (13-2-3) on Wednesday at 6 p.m. in the third round of the NCHSAA 1-A playoffs.
The 17-year-old Matics has had plenty of time between the pipes and has emerged as one of the area's top shot stoppers. He has an 0.85 goals-against average and has recorded 6 shutouts this season for the Stallions, who won the Coastal Plains Conference title for the third consecutive season and hope to advance to the East Regional finals for the third straight time.
"We need to keep moving forward," Matics said. "You always like to go a lot farther."
Matics' journey toward becoming a solid goalie has been a tough one.
He worked to become a good midfielder during his first two seasons at Southwest before tearing the anterior cruciate ligament in his right knee late in his sophomore year. The injury required surgery.
But as a junior Matics was determined to be fit enough to get back on the pitch. He hit the field during the first day of tryouts last year only to re-injure his
Having two
Since he couldn't run as well as he would have liked, Matics decided try his hand at being a goalkeeper. That's how much he wanted to play for the Stallions.
"I missed a few weeks (after the second injury), but I used to play goalie when I was smaller and so it wasn't that big of a jump for me," Matics said. "Coach was all for it."
Actually, Matics had to prove to Sweeney that he could play the goalkeeper position at a high level. It didn't take long for Sweeney to notice that Matics was the best fit between the pipes.
Last year Matics sported an 0.68 goals-against average and recorded 10 shutouts to make the second team of The Daily News all-area team.
This season, it seems as if the position was a natural fit for Matics, who has also kicked for Southwest's football team the past two years.
"Honestly, Nick has had the athletic gifts from the beginning," Sweeney said. "He's gotten a little better in dealing with 1-on-1 situations and he's gotten better at distributing the ball, which I think a lot of that comes from his experience as a field player.
"We have been fortunate that we haven't asked him to make a lot of saves because our defense has done a terrific job, but when we've needed him to he's come up big on a couple of occasions."
Matics, who made 9 saves Saturday night in Southwest's 6-1 second-round win over Ayden-Grifton, has also sensed he's improved as a goalie.
"My lateral movements are a lot better than last year," he said. "I am also able to predict where the ball is going to be on crosses."
But that's not all.
Matics has emerged as a leader for the Stallions. Like most goalkeepers, he is depended on to direct his backfield.
"The goalie has to be able to talk," he said. "We have some young players out there and I have to keep them in the right direction."
Sweeney said Matics has done just that, not only in games but also in practice.
"Here at practice, if I have to be late because of a meeting, Nick will make sure we run a tight ship," the coach said. "He always speaks to the guys after practice and shares his assessment of the day's performance. He's just been a vocal leader for us."
And Matics hopes his contributions pay off not only with a Stallions' victory over Spring Creek on Wednesday but with a state title. Last year, Southwest defeated Spring Creek 5-0 in the second round with the Stallions losing to the Gators 3-1 in the second round in 2009.
"Spring Creek," Matics said, "they are always a good team."


text:
If the world didn't change business would be easy. Nothing ever stays the same and certainly not in today's business environment. The need for speed and adaptation has never been more pressing but still most medium and large companies are very slow to adapt to changing business conditions. Most Executives get this and are exploring solutions that bring agility and flexibility into their organizations.
Meanwhile, today's corporations are built to have a single view of their customers. Segmented data resides in individual departments and is not easily federated across the organization. There are too many unconnected systems, silo databases and laborious processes with countless parochial interests and needs. This predicament slows decision making and project execution while rarely providing management with lessons learned to course correct in the future.
In general, when Executives want performance figures on each of the lines of business it's typically done haphazardly or by asking for specific reports which take weeks to create. This is analogous to the 18th century naval voyages where discovery was taking place but expedition reports didn't come back for months. In today's economic environment where acquiring, servicing and retaining customers is paramount, you are at a competitive disadvantage if you don't have a real-time federated view of the enterprise.


text:
Peter M. Glazer MD, PhD
Robert E. Hunter Professor of Therapeutic Radiology and Professor of Genetics; Chair, Department of Therapeutic Radiology
Research Interests
Gene targeting and gene therapy; Genetic instability in cancer; Mutagenesis; DNA repair; Radiation resistance; Cellular responses to radiation
Current Projects
- Gene targeting and gene therapy for human genetic diseases via triple helix formation.
- Tumor hypoxia, genetic instability, and cancer therapy.
- DNA repair and mutagenesis in transgenic mice.
Research Summary
Gene targeting via triple helix formation: From an interest in studying cellular DNA repair and recombination pathways, we recognized the utility of DNA triple helix formation as a mechanism for the site-specific induction of recombination in human cells. We have recently demonstrated that triplex forming oligonucleotides can be used to mediate targeted modification of human disease-related genes. We are currently optimizing this approach for application in human hematopoietic stem cells and in mouse models of human genetic diseases.
Tumor hypoxia, genetic instability, and cancer therapy: We discovered that tumor hypoxia is a key driver of genetic instability in human cancer cells. Mechanistically, we determined that this instability arises because of suppression of the DNA mismatch repair and homology dependent repair pathways, due to specific repression of the MLH1 and BRCA1, genes, respectively. This down-regulation of DNA repair in hypoxic cancer cells renders them vulnerable to therapeutic strategies that exploit the specific repair deficiencies, providing the basis for novel, rationally designed cancer therapies.
Extensive Research Description
Gene targeting via triple helix formation
From an interest in studying cellular DNA repair and recombination pathways, we recognized the utility of DNA triple helix formation as a mechanism for the site-specific introduction of DNA damage in mammalian cells. Using psoralen-conjugated triplex-forming oligonucleotides, we initially demonstrated the feasibility of triplex-targeted mutagenesis in several model systems. We were able to determine conditions under which triplex oligonucleotides can enter cells and efficiently bind to and modify a target site within cells, leading to base pair specific mutations. Experiments with oligonucleotides not tethered to a reactive agent but capable of high affinity third strand binding revealed that triple helix formation can induce DNA repair and recombination in mammalian cells. This work has raised the possibility of using triplex formation as both a gene knock out and a gene correction modality. It has also suggested that unusual DNA structures may provoke repair activity and may contribute to genomic instability. We are currently studying the feasibility of targeting chromosomal genes using this approach, either by directly inducing mutations in the target gene or by stimulating recombination in a site-directed manner.
Tumor hypoxia, genetic instability, and tumor progression
We hypothesized that that acquired genetic instability in cancer cells may arise from the dysregulation of critical DNA repair pathways due to cell stresses within the tumor microenvironment such as hypoxia. We initially confirmed this hypothesis by measuring mutation frequencies in experimental tumors using a lambda-based chromosomal shuttle vector reporter system. To elucidate the mechanism underlying this phenomenon we used a microarray-based approach to screen for hypoxia-regulated DNA repair pathways. We found that hypoxia specifically down-regulates the expression of Mlh1 and Rad51, key mediators of DNA mismatch repair and of homologous recombination in mammalian cells, respectively. Down-regulation of Mlh1 and Rad51 expression by hypoxia was observed in numerous cell lines from a wide range of tissues, and was not correlated with cell cycle profile or hypoxia-inducible factor expression. Rad51 down-regulation was also detected in vivo in the tumor microenvironment, as we observed consistent inverse correlations between hypoxia-marker staining and Rad51 expression by immunofluorescence in cervical and prostate cancer xenograft models. We propose the existence of a hypoxic phenotype in solid tumors, characterized by decreased expression of the critical DNA repair genes, Mlh1 and Rad51, representing a novel mechanism of acquired genetic instability in the tumor microenvironment and dysregulated DNA damage response in cancer cells.
Mechanism of cancer cell killing by cisplatin
Cisplatin is one of the most widely used cancer chemotherapy agents, but its mechanism of action is not fully understood. Current models suggest that cell killing by cisplatin occurs in a cell-autonomous manner via formation of platinum-DNA adducts that, if not removed by DNA repair, block transcription and replication. We have found that there is a separate cell-interdependent pathway of cisplatin killing in which damaged cells can transmit a death signal to neighboring cells. This signal is produced within the damaged cell by the kinase function of the Ku70, Ku80, and DNA-PK complex and is conveyed to the recipient cell by direct cell-to-cell communication through gap junctions. Our findings suggest that DNA-PK activity and gap junction expression in human cancers may influence the clinical response to cisplatin. In addition, strategies to manipulate these cellular components in conjunction with cisplatin treatment may provide new approaches to cancer therapy.
DNA repair and mutagenesis in transgenic mice
We are carrying out mutagenesis studies using a lambda phage vector construct as a chromosomal shuttle vector in transgenic mice and mouse cells. We have determined that p53 overexpression can lessen mutagenesis by UV light, and we have examined the spectrum of x-ray-induced point mutations in mouse cells. In transgenic mice, we have found that locus specific effects can profoundly influence the mutation frequency in a reporter gene, and we have begun to study tissue-dependent variations in the pattern of spontaneous mutagenesis. Recently, we have created doubly transgenic mice carrying not only the lambda shuttle vector for reporting mutations but also a targeted disruption of the mouse PMS2 gene, a homolog of the E. coli mutL gene involved in mismatch repair. The human homolog of this gene has been associated with hereditary colon cancer. We are examining genetic instability in these mice using the lambda vector system. Preliminary work has shown elevated levels of mutation in all tissues tested, in contrast to the limited tissue distribution of cancer in the animals, a difference which highlights the complexity of cancer etiology.
Selected Publications
- Czochor JR and Glazer PM: microRNAs in Cancer Cell Response to Ionizing Radiation. Antioxid Redox Signal. 2013 Nov. 10
- Shahbazian D, Bindra RS, Kluger HM, Glazer PM. (2013) Radiation sensitivity and sensitization in melanoma.Pigment Cell Melanoma Res. 2013 Jul 22.
- Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH and Glazer PM: Targeting cancer with a lupus autoantibody. Sci Transl Med. 2012 Oct 24;4 (157) :157ra142. PMID: 23100628
- McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandalingam K, Kumar P, Shultz LD, Greiner DL, Mark Saltzman W and Glazer PM: Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo. Gene Ther. 2012 Oct 18; Epub 2012 Oct 18. PMID: 23076379
- Lu Y, Chu A, Turker MS and Glazer PM: Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter. Mol Cell Biol. 2011 Aug;31 (16) :3339-50. Epub 2011 Jun 13. PMID: 21670155
- Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 2009 Feb 169(3):1221-9. Epub 2009 Jan 13. Erratum in: Cancer Res. 2009 Apr 169(7):3240.
- Chin JY, Glazer PM. Repair of DNA lesions associated with triplex-forming oligonucleotides. Mol Carcinog. 2009 Apr48(4):389-99. Review.
- Bindra, R.S. and Glazer, P.M. (2007). Repression of RAD51 gene expression by E2F4/p130 in hypoxia. Oncogene 26:2048-57.
- Vasquez, K.M., Narayanan, L., and Glazer, P.M. (2000). Specific mutations induced by triplex-forming oligonucleotides in mice. Science 290:530-3.


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Snohomish wrestling drops Glacier Peak in rivalry match
Panthers defeat district rivals 41-21 in nonleague match
Genna Martin/The Herald
Glacier Peak's Michael Matwichuk wrestles Snohomish's Greg Eagle in the 138-pound match Thursday night at Snohomish High School. Eagle won 14-2.
Genna Martin/The Herald
Glacier Peak's Michael Matwichuk throws Snohomish's Greg Eagle out of the ring in the 138-pound match Thursday night at Snohomish High School. Eagle won 14-2.
Genna Martin / The Herald
Snohomish's Joseph Proffit attempts to pin Glacier Peak's Daniel Bastain in the 145-pound match Thursday night at Snohomish High School. Proffit won 11-2.
Genna Martin / The Herald
Snohomish's Jacob Proffit lifts Glacier Peak's Logan Coleman in the 152-pound match Thursday night at Snohomish High School. Proffit won 4-3 in overtime.
Genna Martin / The Herald
Glacier Peak's Ethan Barr wrestles Snohomish's Keaton Mills in the 132-pound match Thursday night at Snohomish High School. Barr won 10-4.
There will be blood.
Three consecutive bouts were halted to clean up blood -- two Panthers and one Grizzly -- as Snohomish went on to beat crosstown Glacier Peak 41-21 in the first nonleague wrestling meet between the two teams Thursday night at Snohomish High School.
"It's part of the sport, it really is," Snohomish head coach Rob Zabel said. "It's the closest thing we let kids get to MMA. It doesn't faze the kids. We probably see more in practice. And I'm sure (Glacier Peak) does too."
While Snohomish and Glacier Peak had wrestled against each other previously in tournaments, this was the first head-to-head meet between the two schools. It was evident early on that it was going to be a battle.
The blood began spilling in the 152-pound bout when Glacier Peak's Logan Coleman halted play with blood coming from above his right eye. He had it wrapped and taped for the final minute of the third period where he was able to tie the score and force overtime.
In the extra time, Snohomish's Jacob Proffit was awarded the game-winning point on a technical violation by Coleman, giving Proffit a 4-3 decision and helping put the Panthers up 11-3 in the fourth match of the night.
Next time it was the Snohomish wrestler who needed to be patched up. The Panthers' Tanner Perry began to bleed from his mouth in the 160-pound match, before being tended to. The Grizzlies' Jacob Elledge won the bout with a 7-4 decision.
Zabel said that when you have two good wrestling programs go at it, a little bloodshed isn't all that surprising.
"It's two schools that wrestle a physical style," Zabel said. "I wasn't surprised by the amount of blood."
Finally, Snohomish's Kodiak Landis (170-pounds) contributed a little blood to the cause when he injured his nose while wrestling Tyler Sabin. Landis used paper towels to plug his nose while he continued to wrestle, eventually pulling out a close 4-3 decision that Zabel singled out as one of the key moments of the meet.
"Kodiak Landis had a big match for us," Zabel said. "He stepped up big. He's really grown as a wrestler and I couldn't be more proud of him."
With the win, Landis gave his team a 14-6 advantage as Snohomish tried to distance itself from Glacier Peak. At 182-pounds, Justin Kearney fought off Griffin Thomas to earn another close decision, 2-0, that helped the Panthers pad their lead.
"When coaches talk before the meets, there are what you call 'swing matches,'" Zabel said. "Kodiak was one. Justin Kearney was another. Those guys stepped up and really helped us there."
Glacier Peak's Sean Elledge pinned Peder Morrill at 195-pounds and Mosese Fifita won the heavyweight bout with a 4-2 decision to keep the Grizzlies close. But back-to-back pins by Snohomish's Joel Williamson (106-pounds) and Wyatt Butler (113-pounds) sealed the victory for the Panthers.
"This was going to be a tough match," Zabel said. "This was a really good high school wrestling match. Not a lot of pins."
Zabel knew it was going to be a hard-fought battle, but he had faith in his team after a difficult schedule so far this season. Snohomish (8-1 overall) began the season with a loss to defending 4A state champion Tahoma, but has since followed it up with eight straight wins including one against Sedro-Woolley -- which placed sixth in 3A last season.
Glacier Peak (5-1) -- which lost its first meet of the season -- finished 12th at the 3A tournament in 2012. And, right around the corner for Snohomish, is perennial wrestling powerhouse Lake Stevens (fifth last year in 4A).
"We try to find these tough matches," Zabel said. "That way when we're in these tough matches, our kids have that experience. Our kids expect to be in big matches."
At Snohomish H.S.
132–Ethan Barr (GP) dec. Keaton Mills, 10-4; 138–Greg Eagle (S) dec. Michael Matwichuk, 14-2; 145–Joseph Proffit (S) dec. Daniel Bastian, 11-2; 152–Jacob Proffit (S) dec. Logan Coleman, 4-3; 160–Jacob Elledge (GP) dec. Tanner Perry, 7-4; 170–Kodiak Landis (S) dec. Tyler Sabin, 4-3; 182–Justin Kearney (S) dec. Griffin Thomas, 2-0; 195–Sean Elledge (GP) pinned Peder Morrill, 3:29; 220–Tristan Baus (S) pinned Marcus Becerra, 2:15; 285–Mosese Fifita (GP) dec. Alex Fairhurst, 4-2; 106–Joel Williamson (S) pinned Samir Mahmoud, 3:44; 113–Wyatt Butler (S) pinned Mats Haneburg, 4:52; 120–Conner Snow won by forfeit; 126–John Kim (GP) pinned Noah Bomar, 3:33. Records–Glacier Peak 5-1 overall. Snohomish 8-1.
Like our high school sports page on Facebook, follow @HeraldNetPreps on Twitter and look for updates on our Prep Zone blog.Story tags » • Snohomish High School • High School Wrestling • Glacier Peak High School
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text:
part 2
part 4
greg and joey in public restroom
helping out a bud
helping out a bud to cummmmmm
part 3 of the hot brothers
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Pixels: 640X480 | Bitrate: 700K
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They are not brothers, the top is Australian and the bottom is American. I've seen different version of these two guys but not in this website.


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OXFORD, Ohio – The Miami University women's basketball team's new era got off to a successful start on Saturday with a 71-54 exhibition win over Seton Hill. The game marked the debut of new head coach Cleve Wright.
Freshmen guard Jillian Spurlock led three players in double figures with 12 points on 5-for-9 shooting. Sophomore forward Jessica Rupright had 11 points, while junior guard Kindsay Brandt had 10 points and a team-high six assists.
After spotting the Griffins an opening three-pointer, Miami responded with a 15-0 run over the next five minutes. A pair of three-pointers from Brandt and a jumper by freshman forward Nicole Anderson got Miami on the board, while senior guard Haley Robertson also contributed with a three-point basket. A pair of layups from Anderson, along with jumpers from junior guard Courtney Larson and senior forward Kelsey Simon helped to increase the advantage to 25-6 with 9:18 remaining in the period.
The Griffins responded with a 7-0 run to pull within 12. Spurlock answered with a pair of jumpers, while redshirt freshman Tamira Ford hit her first career jumper to make it a 33-15 game at the 4:38 mark. Seton Hill closed the half on a 15-2 run to make it a 35-30 Miami lead going into the break.
Anderson, Brandt and Spurlock led the RedHawks with six points apiece during the first half. Miami shot 50 percent (14-for-28) during the frame, while holding the Griffins to 33.3 percent (9-for-27) shooting.
Seton Hill eventually pulled to within three at 41-38 with 15:22 remaining in the second half. With the RedHawks back up by four, back-to-back layups from sophomore forward Hannah McCue and Rupright made it 48-40 at the 12:16 mark. The Griffins answered with a 5-2 run to pull within five at 50-45 with 8:47 remaining.
Rupright hit back-to-back jumpers to begin a 10-3 run that put the RedHawks up, 60-48, with 4:04 to go. After the Griffins responded with a three-pointer, a pair of free throws from Larson and Brandt, along with a steal and layup by Brandt sealed the contest. Miami hit its shots from the charity stripe down the stretch to finish off a 71-54 victory.
The RedHawks finished the game 27-for-57 (47.4 percent) from the field. They held Seton Hill to 31.3 percent (15-for-48) shooting. Miami outrebounded the Griffins, 41-29, with Anderson and Larson leading the 'Hawks with six rebounds apiece.
Miami opens the regular season on Friday when it hosts Eastern Kentucky for a special noon tip. For $6 fans can enjoy a lunch of sandwiches and soup on the Millett Hall concourse, beginning at 11 a.m. The price includes a ticket to the contest. For those who cannot be in attendance, it will be broadcast live on Miami All-Access for those who have a subscription.


text: Hamilton Stings Lathrop 09/08/2012 01:44 AM 09/08/2012 01:51 AM Hamilton Stings Lathrop By Associated Press 09/08/2012 01:51 AM Lathrop suffers its first loss of the season against Hamilton. Lathrop 14Hamilton 32Lathrop (2-1) hosts West Platte next week.Hamilton (3-0) plays at Mid-Buchanan next week. Copyright 2013 Nexstar Broadcasting, Inc. All rights reserved. Page: [[$index + 1]] hamilton high school football lathrop sports


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It comes less than 20 hours after the Wolfpack completed a 7-5 regular season by defeating Boston College.
Athletics director Debbie Yow's decision means she'll hire a new football coach barely a year after her new men's basketball hire, Mark Gottfried, made his debut with the school.
O'Brien posted a 40-35 record with the Wolfpack, which is in line for its third consecutive bowl game this year. Eight of the victories came against Football Championship Subdivision opponents.
Offensive coordinator Dana Bible will serve as interim head coach for the upcoming bowl game. All assistants have been retained to continue bowl preparations.
O'Brien's contract runs through December 2015 and he will be paid at least $1.2 million for a period covering that span. O'Brien and Yow agreed on only so much.
"I told them it's really fairly simple," Yow said. "Coach O'Brien and I agree on the goal of becoming a Top 25 program. We just don't agree on what it takes to do that, how to get there."
O'Brien, 64, had tried to set a foundation of his achievements during the past week, repeatedly pointing to what became 24 victories a cross a three-year stretch as one of the most successful spans of that duration in the program's history. He also pointed to what will be three consecutive bowl appearances.
But those accomplishments went only so far for a team that, despite defeating then-No. 3 Florida State, seemed to flop at inopportune time. Under O'Brien, N.C. State won five times in a row against rival North Carolina until blowing a fourth-quarter lead and losing last month in Chapel Hill.
N.C. State went 22-26 in the Atlantic Coast Conference under O'Brien, who joined the Wolfpack after coaching at Boston College. His ACC mark with the Wolfpack included a 1-14 record in road games against other teams in the Atlantic Division.
"Coach O'Brien's service to N.C. State over the last six years has been sincerely appreciated by Wolfpack Nation," Yow said in a statement. "We especially appreciate his attention toward NCAA rules compliance, a value that will continue to be held by N.C. State."
The 2010 team finished with a No. 25 national ranking after defeating West Virginia in the Champs Sports Bowl.
"I appreciate the opportunity to have coached at North Carolina State University and I feel that the program is in a better place now than when I started," O'Brien said in a statement. "I'm proud of the young men that I have coached here, for their accomplishments on the field and in the classroom. Wolfpack football is as sound academically as it's ever been. … I appreciate all of my coaches and wish them the best and I look forward to life after football."
O'Brien is known as a no-nonsense disciplinarian and that provided a different imagine in the position that his predecessor, Chuck Amato, had. So there was an adjustment from Amato's flamboyant style to the more reserved O'Brien.
Still, there was a gamble O'Brien took prior to the 2011 season when he made it clear that rising junior quarterback Mike Glennon would be first-string player even if Russell Wilson chose to return to N.C. State after a second consecutive spring and summer tour in the minor leagues as a professional baseball player.
Wilson landed at Wisconsin for his final college season, then became the starter for the NFL's Seattle Seahawks this year. But Glennon held his own and O'Brien has referred to him as the team's best player this season.


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CHARLESTON — Those familiar with the Federal judiciary were united Thursday in their belief that reports from the United States Attorney's office could signal bad news for some Mingo Countians.
First, County Commissioner David Baisden decided to change the plea in his case from not guilty to guilty. That signaled to courthouse observers to believe Baisden, who attempted to extort a lower price for tires for his personal use from Appalachian Tire, had agreed to cooperate with Federal authorities in their on-going investigation of corruption.
Then, later in the day, Circuit Judge Michael Thornsbury agreed to an "information" in Federal court. While Thornsbury stood strong and loudly proclaimed, "Absolutely not guilty" to an earlier charge involving a conspiracy to put the husband of an ex-lover in jail, an "information" normally indicates a defendant will plead guilty and cooperate with the authorities.
Earlier charged in the conspiracy indictment, Thornsbury has apparently agreed to plead guilty in the new "information" regarding drug trafficking in Mingo.
While most of the trail involving the drug trafficking seems to lead to the late Sheriff Eugene Crum, Thornsbury's agreement to cooperate with the government may indicate difficult times are ahead for some.
From the onset of the investigation, local insiders have maintained that many of the acts that have occurred over the past few years are drug and/or election related. Thursday's "information" would appear to support that concept.
Still, the major theory arising from both Baisden and Thornsbury's cooperative stance with the government is that there are "bigger fish to fry" in Mingo County. As the apparent leader of at least part of the political power structure in Mingo, Thornsbury's "information" has raised the most interest from courthouse observers.
One political consultant close to the investigation said, "You can bet Judge Thornsbury has agreed to provide the Feds with inside information about someone bigger than he is. That's the only reason the government would agree to an 'information.'"
At first glance, it is difficult to understand what "fish" might be bigger than the powerful circuit judge. The indictment and information almost make Thornsbury look like the ruling dictator of Mingo County, with various officials jumping to satisfy his demands and requests.
On the other hand, it is possible that United States Attorney Booth Goodwin and his staff would consider anyone above the county official level as a "bigger fish."
Many think a look at financial reports filed by "Team Mingo," of which Baisden and Thornsbury were key members, might reveal exactly who Federal agents are targeting. It is generally agreed that the drug trafficking along with the shooting death of Sheriff Crum are related to the overall conspiracies underway in Mingo.
One certainty is that Goodwin repeated Thursday that his investigation is on-going.
Perhaps the biggest loser of reputation to date is the late Sheriff Crum. Gunned down and being praised for his role in prosecuting drug trafficking in Mingo County, Crum was elevated to a high level of esteem statewide. Initially, reports were that his shooting death as he ate his lunch across from the Mingo Courthouse was "drug-related."
Officials quickly doused that claim, saying the incident had nothing to do with drugs. Now, however, the theory is that "G.W." identified in the "information" filed Thursday has a key role in illegal drug operations in Williamson and vicinity. As such, the theory that Crum's death was drug-related has arisen again.
In a story that would have more twists and turns than any made-for-TV movie made to date, the current Mingo situation involves love affairs, drugs, money laundering, illegal campaign activities and more. Still, those with a keen eye on the matter continue to insist "this is only the tip of the iceberg."
While it may take awhile to see what Baisden and Thornsbury are able to do for Federal prosecutors, the end result will likely confirm or disprove many of the theories being floated throughout the county at this time.


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As far as the desert religions go, tolerance has become a withered, weed which threatens the garden, We quite simply, as citizens of the world cannot afford these child like fantasy which can turn violent on a dime. We must face the fact that humanity like it or not, needs to grow up [mentally] if we are to survive. We simply cannot allow the most ignorant, the most child like among us to lead the way. As Martin Luther once said, reason is the enemy of faith, they lay it out for you, you just cannot afford to listen to these people babble and run for office. May Allah behead all those whom you do not like!! Never suffer a witch to live, good grief people, its time, it is really time. Disrespect and intolerance is what is presently called for, if its laughable, laugh at it. To show tolerance for willful ignorance, is NOT a virtue.
That is consistent with something Ayn Rand said in The Virtue of Selfishness:
> I will confine my answer to a single, fundamental aspect of this question. I will name only one principle, the opposite of the idea which is so prevalent today and which is responsible for the spread of evil in the world. That principle is: One must never fail to pronounce moral judgment. Nothing can corrupt and disintegrate a culture or a man's character as thoroughly as does the precept of moral agnosticism, the idea that one must never pass moral judgment on others, that one must be morally tolerant of anything, that the good consists of never distinguishing good from evil. It is obvious who profits and who loses by such a precept. It is not justice or equal treatment that you grant to men when you abstain equally from praising men's virtues and from condemning men's vices. When your impartial attitude declares, in effect, that neither the good nor the evil may expect anything from you—whom do you betray and whom do you encourage?
Rand, Ayn (1964-11-01). The Virtue of Selfishness (Signet) (p. 70). Penguin Group. Kindle Edition.