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Wednesday, December 23, 2009
Napa | (release date November 2010) | RED | 100 |
Napa | (release date April 2011) | RED | 97+ |
Napa | (release date April 2011) | RED | 99 |
Napa | (release date April 2011) | RED | 97 |
Napa | (release date November 2010) | RED | 95 |
Colgin's 2007's, which include their final vintage of Cabernet Sauvignon from the Herb Lamb Vineyard, are all extraordinary, world-class wines. The change in winemakers from Mark Aubert to Allison Tauziet has gone very smoothly, and was made easier by the retention of the highly respected French wine consultant, Dr. Alain Raynaud, who told me that tasting Colgin's 2007s gave him his greatest emotional high since he tasted the Château Pavie 2000!
The opaque purple-colored 2007 Cabernet Sauvignon Herb Lamb Vineyard possesses an extraordinary bouquet of crushed rocks, crème de cassis, bay leaf, and forest floor. It is an exuberant, full-bodied, pure Cabernet that should drink well for 25+years. Given the vintage and the sweetness of the tannin, it is atypically accessible already. From Ann Colgin's tiny vineyard treasure just off of Highway 29, north of St. Helena, the 2007 Cabernet Sauvignon Tychson Hill Vineyard (225 cases produced) boasts an opaque blue/purple color as well as a refined and noble nose of charcoal, graphite, ink, blueberries, black currant liqueur, licorice, and cedarwood. Full-bodied with more tannin and structure than the Herb Lamb, this powerful, rich 2007 will benefit from 4-5 years of cellaring, and should keep for 30 or more years.
Potentially perfect is the 550-case blend of 52% Cabernet Sauvignon, 28% Merlot, 12% Cabernet Franc, and 8% Petit Verdot, the 2007 Cariad. Its inky/blue/purple color is followed by a stunningly complex perfume of incense, camphor, forest floor, underbrush, blueberries, blackberries, and a hint of smoky meat. A wine of extraordinary purity, full-bodied intensity and richness, and a flawless integration of acidity, tannin, wood, and alcohol, this superb Bordeaux blend should evolve for 25-30 years. The staggeringly rich, complex, harmonious, impeccably well-balanced 2007 IX Proprietary Red Estate (1,400 case produced) exhibits aromas of spring flowers, cedarwood, Asian spices, licorice, blueberries, and blackberries. A distinct liqueur of minerals buttresses the full-bodied, massive concentration, giving an overall impression of elegance, purity, and harmony. This is another seamless tour de force in winemaking. It should drink well for 25 or more years. There are 475 cases of the 2007 IX Syrah Estate, which offers up flowery, roasted meat, balsamic, tar and blackberry characteristics in a full-bodied format. The wine reveals sweet tannin, and layers of fruit, including a note of lavender that emerges as the wine sits in the glass. It should drink well for a decade.
The 2008s will not be available until 2011, but it appears to be a very successful vintage for Colgin. The crop was tiny, and there were no frost issues, but several heat spikes did occur. Both Allison Tauziet and Alain Raynaud thought that the small berries provided powerful fruit intensity. The 2008 Cabernet Sauvignon Tychson Hill Vineyard is slightly lighter than the 2007, but it reveals classic notes of cedarwood, black currants, licorice, and spice box. It is surprisingly approachable with sweet tannin and a long, heady finish. A blend of 55% Cabernet Sauvignon, 30% Merlot, 9% Petit Verdot, and 6% Cabernet Franc (all from David Abreu's vineyard), the 2008 Cariad exhibits notes of damp earth, roasted herbs, blueberries, blackberries, flowers and a hint of black olives. While is has some dusty tannins to resolve, it possesses plenty of potential. The 2008 IX Proprietary Red Estate (61% Cabernet Sauvignon, 22% Merlot, and the Cabernet Franc and Petit Verdot) boasts abundant notes of flowers, blueberries, blackberries, camphor, lead pencil, and subtle roasted herbs. The juicy aromas are followed by a round, opulent, elegant wine possessing terrific concentration as well as sweet tannins. Lastly, the 2008 IX Syrah Estate reveals the blackberry, black olive, tapenade, northern Rhône-like character intertwined with smoky, meaty notes, lots of wild herb and pepper characteristics, good acidity, and medium to full body. It should drink well for 7-8 years.
Tel (707) 963-0999; Fax (707) 963-0996.


text:
View of Two U.S. Spacecraft on the Moon
May 4, 2003
View of two U.S. spacecraft on the surface of the moon, taken during the second Apollo 12 extravehicular activity (EVA-2). The Apollo 12 Lunar Module is in the background. The unmanned Surveyor III spacecraft is in the foreground.
Environment, Technology Internet, Extra-vehicular activity, Apollo 12, Apollo program, Surveyor 1, Surveyor 3, Apollo Lunar Module, Apollo 17, Apollo spacecraft, Spacecraft

subset: commoncrawl


text:
Aravinthan, Vasantha and Aravinthan, Thiru (2010) Effectiveness of self-assessment quizzes as a learning tool. In: EE 2010: Inspiring the Next Generation of Engineers , 6-8 Jul 2010, Birmingham, UK.
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Aravinthan_Aravinthan_EE2010_PV.pdf Download (220Kb) |
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To enhance the students' learning experience, self-assessment formative quizzes are being incorporated into the curriculum by several lecturers. With the technological developments in webbased delivery, online quizzes may be an effective learning tool, especially when courses are offered via external mode of study. Among the several advantages of providing online quizzes, the most attractive feature is providing the correct answer and appropriate feedback immediately after students attempt a quiz. This paper evaluates the overall performance of students in two engineering courses where self-assessment quizzes were made available through the e-learning system. As formative assessment, it was noted that the frequent attempts by students tend to cluster near the final examination period, however, a few students attempted them as soon as they were released. The results showed there is a strong correlation between students who attempt the quizzes and their overall student performance assessed by final grades. This paper will further discuss the important aspects that need to be considered when developing well formulated quizzes for technical courses and thereby maximising their potential as an effective learning tool.
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Item Type: | Conference or Workshop Item (Commonwealth Reporting Category E) (Paper) |
Refereed: | Yes |
Item Status: | Live Archive |
Additional Information: | 'Copyright © 2010 Aravinthan, V and Aravinthan, T: The authors assign to the EE2010 organisers and educational non-profit institutions a non-exclusive licence to use this document for personal use and in courses of instruction provided that the article is used in full and this copyright statement is reproduced. The authors also grant a non-exclusive licence to the Engineering Subject Centre to publish this document in full on the World Wide Web (prime sites and mirrors) on flash memory drive and in printed form within the EE2010 conference proceedings. Any other usage is prohibited without the express permission of the authors.' Deposited with permission of authors. |
Depositing User: | Dr Vasantha Aravinthan |
Faculty / Department / School: | Historic - Faculty of Engineering and Surveying - Department of Agricultural, Civil and Environmental Engineering |
Date Deposited: | 31 Oct 2010 02:07 |
Last Modified: | 02 Jul 2013 23:58 |
Uncontrolled Keywords: | self-assessment; web-based delivery; quizzes; e-learning systems; effective learning; engineering course; formative assessment; learning tool; student performance |
Fields of Research (FOR2008): | 13 Education > 1302 Curriculum and Pedagogy > 130212 Science, Technology and Engineering Curriculum and Pedagogy 13 Education > 1303 Specialist Studies in Education > 130303 Education Assessment and Evaluation 13 Education > 1303 Specialist Studies in Education > 130309 Learning Sciences |
Socio-Economic Objective (SEO2008): | E Expanding Knowledge > 97 Expanding Knowledge > 970113 Expanding Knowledge in Education |
URI: | http://eprints.usq.edu.au/id/eprint/8441 |
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Kingdom | Phylum | Class | Order | Family |
Scientific Name: | Cephalophus spadix | |||
Species Authority: | True, 1890 | |||
Common Name(s):
Red List Category & Criteria: | Endangered C2a(i) ver 3.1 | |||||||||||||||||||||
Year Published: | 2008 | |||||||||||||||||||||
Date Assessed: | 2008-06-30 | |||||||||||||||||||||
Assessor(s): | Moyer, D.C., Jones, T. & Rovero, F. | |||||||||||||||||||||
Reviewer(s): | Mallon, D.P. & Plowman, A. (Antelope Red List Authority) | |||||||||||||||||||||
Justification: Population data are scarce, but best estimates indicate fewer than 1,500 individuals in four disparate and fragmented subpopulations. This is based on estimated maximum density at sites were it is locally common and total area of suitable habitat available at all sites were its presence has been recently confirmed. In recent years, Abbott's Duiker is thought to have become locally extinct in several locations from where it had been recorded previously. |
History: |
Range Description: | A Tanzanian endemic found in a few montane and submontane forests and one lowland forest in the Eastern Arc Mountains, Mount Kilimanjaro and Southern Highlands. Formerly recorded from the forests patches along the top of the Gregory Rift between Babati and Mbulu. In the Eastern Arc, it is currently reported only from West Usambara Mountains and Udzungwa Mountains, while it probably disappeared from the Uluguru and East Usambara Mountains (Wilson 2001; Moyer 2003; Rovero et al. in press). Its status in other Eastern Arc forests is unknown; however, recent surveys failed to detect its presence in North Pare, South Nguru and Uluguru Mountains (F. Rovero, unpubl.). There are old records from the escarpment forests in eastern Njombe District (Swynnerton and Hayman 1951) but the status of these forests is uncertain and under investigation. Wilson (2001) noted that Abbott's Duiker was still present on the Poroto Mountains in 1958 but the status of that population is also uncertain. A small population is still present on Mount Rungwe and the Livingstone Forest within the new Kitulo National Park. The Udzungwa Mountains and Mount Kilimanjaro might hold the only two viable populations (Rovero et al. in press). |
Countries: | Native: Tanzania, United Republic of |
Range Map: | Click here to open the map viewer and explore range. |
Population: |
Although data are scarce, the total population is probably less than 1,500 individuals. Maximum densities in the Udzungwa Mountains are estimated at 1.3 individuals/km² (Rovero et al. in press), i.e. this species is at low densities even where locally common. Udzungwa Mountains subpopulations: Mwanihana Forest (177 km², 300-2,300 m, within Udzungwa Mountains National Park): locally common. Luhombero Forest (250 km², 1,350-2,500 m, West Kilombero Forest Reserve/Udzungwa Mountains National Park): locally common (Jones, unpubl.). Uzungwa Scarp Forest Reserve (180 km², 300-2,050 m): rare. Matundu Forest Reserve (176 km², 300-1,000 m): rare. Ukami forest (6 km², 1,100-1,600 m): locally common. Nyumbanitu Forest Reserve (49 km², 1,350-2,500 m): scarce. Southern Highlands: very rare, with some 40 individuals estimated in Mount Rungwe and adjacent Livingstone forest (T. Davenport and S. Machaga, unpubl.). They may also persist in a few other Southern Highland forests currently being surveyed. A new population, estimated at a maximum of 50 individuals, was found in 2006 in the southern Rubeho Mountains (?Ilole forest, 30 km²), where the species is locally common (F. Rovero, unpubl.). Population abundance in Mount Kilimanjaro and West Usambara is unknown. |
Population Trend: | Decreasing |
Habitat and Ecology: |
Found in interior and clearings of mature montane and submontane forest. In Mount Kilimanjaro, this duiker is reported as commonest between 1,300 and 2,700 m asl. (Grimshaw et al. 1995). In the Udzungwa Mountains, Abbott's Duiker has been recorded as low as 300 m in Matundu Forest a large, lowland and semi-deciduous forest (F. Rovero, unpubl.), as well as on the highest peak (Mount Luhombero, 2,600 m; Rodgers and Swai 1988). It is known from disturbed and secondary montane forest and bamboo forest to 2,500 m and occasionally plateau grassland to 2,800 m on Mount Rungwe and in Livingstone-Kitulo in the Southern Highlands (T. Davenport and S. Machaga unpubl.). Very little is known of Abbott's Duiker ecology and behaviour. This is an extremely secretive species, occurring at low densities and very rarely seen even where it is considered relatively common. Furthermore, it appears to be mainly nocturnal and crepuscular (F. Rovero unpubl.) and, as with most duiker species, probably prefers dense, understory vegetation. They have been seen browsing forest understory leaves, and marshy vegetation in forest clearing; also one individual photographed with a frog in its mouth. Abbott's Duikers are known to be predated by leopards (Panthera pardus), and juveniles are probably predated by African Crowned Eagles (Stephanoetus coronatus) and pythons (Python spp). In the Udzungwa Mountains, the Lion (Panthera leo) and the Spotted Hyeana (Crocuta crocuta) are also potential predators (Rovero et al. in press, Moyer unpubl. data). |
Systems: | Terrestrial |
Major Threat(s): | A major threat to this species is snaring, which is taking place at low level within Udzungwa Mountains National Park (Mwanihana Forest), where there is a relatively high level of protection. Snaring has also been reported from other sites (Uzungwa Scarp Forest Reserve, Southern Highlands, West Usambara Mountains), but at higher levels. Abbott's Duiker is also affected by loss of habitat due to agricultural encroachment, and selective logging. Virtually nothing is known of the ecology of this species, but selective logging may be predicted to adversely affect a duiker of the body size and low density of Abbott's Duiker (Struhsaker 1997). |
Conservation Actions: |
Udzungwa Mountains National Park is patrolled by anti-poaching rangers, and zero utilization of animals is permitted. However, the capture of Abbott's Duiker in snares is still occurring in Mwanihana Forest within the Park. With exception of Mount Kilimanjaro, where most of the forests were recently included in the National Park, there is no management in all the other sites. Current work in the Southern Highlands employing hunters in environmental education initiatives in exchange for stopping hunting, has met with some success. It is too early to say if this will have a significant positive impact on Abbott's duiker populations, although it may prove a valuable model for conservation at other sites and is being carried out alongside the use of Abbott's Duiker as a flagship species in village education programmes. Major conservation management measures that would enhance the protection of Abbott's Duiker are the expansion of the Udzungwa Mountains N.P. to include important forests currently unprotected, in particular Uzungwa Scarp, Iyondo and Matundu. Also necessary is the inclusion of Mount Rungwe within the new Kitulo N.P. and greater law enforcement enacted in those areas that are currently not adequately protected (such as Southern Highland forests, Usambara and Uluguru Mountains). Critical forest connections, such as the degraded Bujingijila corridor linking Mount Rungwe to Livingstone forest in Kitulo, must be adequately protected. |
Ansell, W. F. H. 1972. Part 2, 15 Family Artiodactyla. In: J. Meester and H. W. Setzer (eds), The Mammals of Africa: An Identification Manual, pp. 1-84. Smithsonian Institution Press, Washington, DC, USA. Baillie, J. and Groombridge, B. (comps and eds). 1996. 1996 IUCN Red List of Threatened Animals. IUCN, Gland, Switzerland and Cambridge, UK. Baldus, R., Estes, R. D., Foley, C., Mduma, S., Moyer, D., Siege, L., Grimshaw, J. M. and Newmark, W. 1997. Tanzania. Antelope Survey Update No. 4. In: R. East (ed.), IUCN/SSC Antelope Specialist Group Report, pp. 15-52. IUCN, Gland, Switzerland and Cambridge, UK. Boitani, L., Corsi, F., De Biase, A., D'Inzillo Caranza, I., Ravagli, M., Reggiani, G., Sinibaldi, I. and Trapanese, P. 1999. African Mammals Databank: a databank for the conservation and management of the African mammals. Rome, Italy Available at: http://www.ieaitaly.org/samd/. Dinesen, L., Lehmberg, T., Rahner, M. C. and Fjeldsa, J. 2001. Conservation priorities for the forests of the Udzungwa Mountains, Tanzania, based on primates, duikers and birds. Biological Conservation 99: 223-236. East, R. 1999. African Antelope Database 1999. IUCN, Gland, Switzerland and Cambridge, UK. Grimshaw, J. M., Cordeiro, N. J. and Foley, C. A. H. 1995. The mammals of Kilimanjaro. Journal of the East Africa Natural History Society 84: 105-139. Groombridge, B. (ed.). 1994. 1994 IUCN Red List of Threatened Animals. IUCN, Gland, Switzerland and Cambridge, UK. Groves, C. and Grubb, P. 1974. A new duiker, C. weynsi lestradei, from Rwanda. Revue de Zoologie Africaine 88: 189-196. Haltenorth, T. H. 1963. Klassifikation Säugetiere Afrikas und Madagaskars. BLV Verlagsages schaft, Munchen, Germany. Ionides, C. J. P. 1965. A hunters story. W. H Allen, London, UK. IUCN. 1990. IUCN Red List of Threatened Animals. IUCN, Gland, Switzerland and Cambridge, UK. IUCN. 2008. 2008 IUCN Red List of Threatened Species. Available at: http://www.iucnredlist.org. (Accessed: 5 October 2008). IUCN Conservation Monitoring Centre. 1986. 1986 IUCN Red List of Threatened Animals. IUCN, Gland, Switzerland and Cambridge, UK. IUCN Conservation Monitoring Centre. 1988. 1988 IUCN Red List of Threatened Animals. IUCN, Gland, Switzerland and Cambridge, UK. Kingdon, J. 1982. East African Mammals: An Atlas of Evolution in Africa. Academic Press, London, UK and New York, USA. Kingdon, J. 1997. The Kingdon Field Guide to African Mammals. Academic Press Natural World, San Diego, California, USA. Machaga, S. J. and Davenport, T. R. B. 2004. Hunting on Mount Rungwe: An assessment of the status of forest antelopes. Unpublished report. Wildlife Conservation Society, Mbeya. Moyer, D. C. 2003. Conservation Status of Abbot's Duiker, Cephalophus spadix, in the United Republic of Tanzania. In: A. B. Plowman (ed.), Ecology and Conservation of Small Antelope: Proceedings of an International Symposium on Duiker and Dwarf Antelope in Africa. Nowak, R.M. 1991. Walker's Mammals of the World. The Johns Hopkins University Press, Baltimore, USA and London, UK. Nowak, R.M. 1999. Walker's Mammals of the World. The Johns Hopkins University Press, Baltimore, USA and London, UK. Rodgers, W. A. and Swai, I. 1988. Tanzania. In: R. East (ed.), Antelopes: Global Survey and Regional Action Plans, Part 1: East & Northeast Africa. IUCN, Gland, Switzerland. Roosevelt, T. and Heller, E. 1922. Life Histories of African Game Animals. John Murray, London, UK. Rovero, F., Davenport, T. R. B. and Jones, T. In press. Cephalophus spadix. In: J. Kingdon and M. Hoffmann (eds), The Mammals of Africa, Academic Press, Amsterdam, The Netherlands. Rovero, F., Jones, T. and Sanderson, J. 2005. Notes on Abbott's duiker (Cephalophus spadix True 1890) and other forest antelopes of Mwanihana Forest, Udzungwa Mountains, Tanzania, as revealed by camera-trapping and direct observations. Tropical Zoology 18: 13-23. Rushby, C. G. and Swynnerton, G. H. 1946. Notes on some game animals of Tanganyika Territory. Tanganyika Notes and Records 22: 14-26. Schouteden, H. 1946. De zoogdieren van Belgisch Congo en van Ruanda-Urund Annis. Museum of the Republic of Congo, Belge 3(2): 132-169. Schwarz, E. 1914. Notes on African Ungulates. 1. The classification of the duikers. Annual Magazine of Natural History 13(8): 491-495. Sclater, P. L. and Thomas, P. 1899. Book of Antelopes. R. H. Porter, London, UK. Struhsaker, T. T. 1997. Ecology of an African Rain Forest: Logging in Kibale and the Conflict between Conservation and Exploitation. Univ. of Florida Press, Gainesville, FL, USA. Swynnerton, G. H. and Hayman, R. W. 1951. A Checklist of the Land Mammals of the Tanganyika Territory and the Zanzibar Protectorate. Journal of the East Africa Natural History Society 20(6): 274-392. True, F. W. 1890. Description of two new species of mammals from Mt. Kilimanjaro, East Africa. Proceedings of the Unites States National Museum 13: 227-229. Wilson, V. J. 2001. Duikers of Africa: Masters of the African Forest Floor. Directory Publishers, Bulawayo, Zimbabwe. |
Citation: | Moyer, D.C., Jones, T. & Rovero, F. 2008. Cephalophus spadix. The IUCN Red List of Threatened Species. Version 2014.3. <www.iucnredlist.org>. Downloaded on 26 April 2015. |
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NEWSLETTERS Free Newsletters Archive My Subscriptions NEWS News by Subject News by Disease News by Date PLoS Search News Post Your News JoVE CAREER NETWORK Job Seeker Login Most Recent Jobs Search Jobs Post Resume Career Fairs Career Resources For Employers HOTBEDS Regional News US & Canada Biotech Bay Biotech Beach Genetown Pharm Country BioCapital BioMidwest Bio NC BioForest Southern Pharm BioCanada East C2C Services & Suppliers™ Europe Asia DIVERSITY PROFILES Company Profiles INTELLIGENCE Research Store INDUSTRY EVENTS Research Events Post an Event RESOURCES Real Estate Business Opportunities
by Camila B. Mendes-Silverio, Luiz O. S. Leiria, Rafael P. Morganti, Gabriel F. Anhê, Sisi Marcondes, Fabíola Z. Mónica, Gilberto De Nucci, Edson Antunes
Nitric oxide-independent soluble guanylyl cyclase (sGC) activators reactivate the haem-oxidized enzyme in vascular diseases. This study was undertaken to investigate the anti-platelet mechanisms of the haem-independent sGC activator BAY 60-2770 in human washed platelets. The hypothesis that sGC oxidation potentiates the anti-platelet activities of BAY 60-2770 has been tested.
Human washed platelet aggregation and adhesion assays, as well as flow cytometry for aIIbß3 integrin activation and Western blot for a1 and ß1 sGC subunits were performed. Intracellular calcium levels were monitored in platelets loaded with a fluorogenic calcium-binding dye (FluoForte).
BAY 60-2770 (0.001–10 µM) produced significant inhibition of collagen (2 µg/ml)- and thrombin (0.1 U/ml)-induced platelet aggregation that was markedly potentiated by the sGC inhibitor ODQ (10 µM). In fibrinogen-coated plates, BAY 60-2770 significantly inhibited platelet adhesion, an effect potentiated by ODQ. BAY 60-2770 increased the cGMP levels and reduced the intracellular Ca2+ levels, both of which were potentiated by ODQ. The cell-permeable cGMP analogue 8-Br-cGMP (100 µM) inhibited platelet aggregation and Ca2+ levels in an ODQ-insensitive manner. The cAMP levels remained unchanged by BAY 60-2770. Collagen- and thrombin-induced aIIbß3 activation was markedly inhibited by BAY 60-2770 that was further inhibited by ODQ. The effects of sodium nitroprusside (3 µM) were all prevented by ODQ. Incubation with ODQ (10 µM) significantly reduced the protein levels of a1 and ß1 sGC subunits, which were prevented by BAY 60-2770.
The inhibitory effects of BAY 60-2770 on aggregation, adhesion, intracellular Ca2+ levels and aIIbß3 activation are all potentiated in haem-oxidizing conditions. BAY 60-2770 prevents ODQ-induced decrease in sGC protein levels. BAY 60-2770 could be of therapeutic interest in cardiovascular diseases associated with thrombotic complications.


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Boston bombing survivors return to marathon, one year after attack
Among the 36,000 runners who took part in the Boston marathon on Monday, one group stood out for their courage - survivors of last year's deadly twin bombing.
Ms Celeste Corcoran was one of them. The 47-year-old was standing near the finish line to cheer on her sister Carmen Acabbo at last year's marathon when the bomb went off. She lost both legs and suffered a ruptured right eardrum in the attack which killed three people and injured 264. Her 19-year-old daughter, Sydney, who was with her, nearly bled to death after shrapnel flew into her right thigh, according to the Boston Globe.
On Monday, Ms Corcoran, fitted with a pair of prosthetic blades, and her daughter joined Ms Acabbo near the Boston Marathon finish line at about 4pm. The trio ran the last block together, surrounded by journalists. She raised her hands in the air and said: "We did it."
"Negative power is officially gone from this spot... Terrorists never, ever win," she was quoted as saying by the Boston Globe. "For me, I did this for every single person who can't run this race."


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Welcome to Ayres Hotels Event Calendar
Sort By
24 August 2013
Starting July 11th, the LA Zoo and Botanical Gardens are inviting anyone 18
and older to explore the LA Zoo after hours. Enjoy live entertainment including music and stand-up ...Read More
Phone - (323)-644-6042
Venue - Los Angeles Zoo & Botanical Gardens
Festival of Arts of Laguna Beach presents, Pageant of the Masters. This must see event uses real people to portray famous paintings. The unique ability of the artists to make ...Read More
Phone - (949)-497-6582
Venue - Festival of Arts, Laguna Beach
Movieland Wax Museum building presents 'Titanic The Experience'. This exhibit shows you the experience of the Titanic in a fascinating way. It opens 10 a.m. to 9 p.m. Monday - ...Read More
Phone - 404842260
Venue - Movieland Wax Museum Building
Movieland Wax Museum building presents 'Bodies...The Exhibition'. This exhibit shows people how their bodies work and how different habits affect them. The visual and hands-on ...Read More
Phone - (404)-842-2600
Venue - Movieland Wax Museum Building


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California Montecito
Bloom & Plume Felici Events Jamie Flam Michael & Anna Costa Photographers Ltd. Zohe Felici
Rockstar Transportation
San Ysidro Ranch
Pink White
If you have been hanging out with SMP for a little while now, you know two things: one, we love San Ysidro Ranch and two, we love when Michael & Anna Costa get behind the lens. And when those two things collide, we get a take-your-breath-away beauty like this little wedding right here. It's full of that simple, sophisticated style that goes so well with the pretty backdrops of this venue, and topped off with a couple who's smiles say it all. It has everything we love here at SMP, and you can see it all right here!
From Michael & Anna Costa Photographers Ltd.… Nestled in the backwoods of Montecito, California, is not only the perfect spot for a wedding, but also for delighting in the wonderland that is San Ysidro Ranch. Aki and Imraan opted for a secluded and intimate celebration of their nuptials and the Wine Cellar at San Ysidro Ranch couldn't have been more perfect — a thousand paper cranes swaying from the trees and family closely surrounding them they exchanged vows. Incorporated in their ceremony were Japanese, Indian and Western traditions that perfectly complemented their blending of cultures. Between the lavender fields and olive trees, the pergola of jasmine and roses — photo backdrops were endless. And as they dined amongst a myriad of pink peonies, the evening twinkled with the warmth of flickering candles and moonlight.
Wedding Photography: Michael & Anna Costa Photographers Ltd. / Wedding Venue: San Ysidro Ranch in Montecito, California / Event Planning: Zohe Felici of Felici Events / Floral Design: Bloom & Plume / Catering + Wedding Cake: San Ysidro Ranch / Music: Jamie Flam / Transportation: Rockstar Transportation / Hair + Makeup: Sarah Lisa + Tomiko


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12-27-2013, 06:02 PM | #1 (permalink) |
Senior Member
Join Date: Jan 2013
Posts: 203
Salomon Villain vs. Classicks
Upon research i have turned up with nothing substantial. I am curious what the differences are between a salomon villain and the villain classicks. From what i can determine the classicks version is just a bit more damp?
I have a hard time de-coding the stupid over-technical language the companies use so any comments would be much appreciated P.S. if the angry snowboard would comment on this i'd be quite pleased! You have a great review of the standard version! |
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12-27-2013, 10:39 PM | #4 (permalink) |
Veteran Member
Join Date: Nov 2011
Location: North Seattle
Posts: 880
i think the classicks just have an extra rubber layer in the laminate process. Should be a very subtle ride difference. really is mostly graphics. I like my villain a lot, i have been riding it instead of my banana magic every day this season.
Dude, suckin at somethin' is just the first step to bein' sorta good at somethin' |
01-01-2014, 06:53 AM | #8 (permalink) |
Senior Member
Join Date: Dec 2013
Location: Lithuania
Posts: 358
dont know how in 2013, but in 2014 it is clearly stated, that assasin and villain classics hase extra dampening layer and Area 51 base instead of sintered eg, area 51 should be faster one. Speaking about 2013 sabotage and sabotage clasics, the only different is top layer colour and mateliar, which leads to classic beeing slightly lighter, dont know nothing about 2013 assasin and villain.
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The Clorox Building, Clorox's diamond-shaped headquarters in Oakland
Public | |
Traded as | |
Industry | |
Founded | Oakland, California, U.S. (May 3, 1913 ) |
Founder |
Headquarters | Clorox Building, Oakland, California, U.S. |
Area served
Worldwide |
Key people
Benno Dorer (CEO) |
Products |
Revenue | US$5.5 Billion[1] (2014) |
US$977 Million[1] (2014) | |
US$579 Million[1] (2014) | |
Total assets | 2014 |
Total equity | US$154 Million[1] (2014) |
Number of employees
7,700[1] |
Slogan | We make everyday life better, every day |
Website | thecloroxcompany |
The Clorox Company, based in Oakland, California, is an American multinational manufacturer and marketer of consumer and professional products with approximately 7,700 employees worldwide as of Dec. 1, 2014.[1] The company's fiscal year 2014 net sales were $5.5 billion,[1] which ranked #451 on Fortune's 2014 Fortune 500 list.[2]
Clorox products are sold primarily through mass merchandisers, retail outlets, e-commerce channels, distributors and medical supply providers.[3] Clorox brands include its namesake bleach and cleaning products, as well as Brita, Burt's Bees, Formula 409, Glad, Hidden Valley, Kitchen Bouquet, KC Masterpiece, Soy Vay, Kingsford, Liquid-Plumr, Mistolin, Pine-Sol, Poett, Tilex, S.O.S., and Fresh Step, Scoop Away and Ever Clean cat litters.[4]
In 2008, The Clorox Company became the first major consumer packaged goods company to develop and nationally launch a natural cleaning line, Green Works, into the mainstream cleaning aisle.[5]
In 2011, The Clorox Company integrated corporate social responsibility (CSR) reporting with financial reporting. The company's annual report for the fiscal year ending in June 2011 shared data on financial performance as well as advances in environmental, social and governance performance.[6]
The product and the company date back to May 3, 1913, when five entrepreneurs, Archibald Taft, a banker; Edward Hughes, a purveyor of wood and coal; Charles Husband, a bookkeeper; Rufus Myers, a lawyer; and William Hussey, a miner, invested $100 each to set up the first commercial-scale liquid bleach factory in the United States, on the east side of San Francisco Bay.[7] The firm was first called the Electro-Alkaline Company.[7] The name of its original bleach product, Clorox, was coined as a portmanteau of chlorine and sodium hydroxide, the two main ingredients. The original Clorox packaging featured a diamond-shaped logo, and the diamond shape has persisted in one form or another in Clorox branding to the present.
The public, however, didn't know very much about liquid bleach when Clorox bleach debuted. Although the Electro-Alkaline Company started slowly, and was about to collapse quickly, it would not be until 1916 when investor William Murray took over the company as general manager and convinced his wife, Annie, to hand out free, 15-ounce, sample bottles to the public at their family grocery store in Oakland. Not long after, word began to spread public and, in 1917, the Electro-Alkaline Company began shipping Clorox bleach to the East Coast via the Panama Canal.
In 1928, the company went public on the San Francisco stock exchange and changed its name to the Clorox Chemical Company. "Butch," an animated Clorox liquid bleach bottle, was used in advertising and became well-known, even surviving the 1941 transition from rubber-stoppered bottles to ones with screw-off caps.[8]
The Clorox Chemical Company was strong enough to survive the Great Depression throughout the 1930s, achieving national distribution of Clorox bleach in the process, but during World War II, even though Clorox bleach proved useful as a first aid product for American armed forces, one of the bleach's ingredients was being rationed, as, under U.S. government orders, chlorine gas shortages forced many bleach manufacturers to reduce the concentration of sodium hypochlorite in their products, thus diluting them with water. Clorox, however, declined and elected to sell fewer units of a full-strength product, establishing a reputation for quality.[8]
In 1957, Clorox was purchased by Procter & Gamble, which renamed its new subsidiary "The Clorox Company." Almost immediately, a rival company objected to the purchase, and it was challenged by the Federal Trade Commission, which feared it would stifle competition in the household products market. The FTC won in 1967 after a 10-year battle, in which the U.S. Supreme Court ruled that P&G must divest The Clorox Company, and on January 1, 1969, Clorox became independent again.
Throughout the 1970s and 1980s, Clorox pursued an aggressive expansion program in which it attempted to establish itself as a major diversified consumer products conglomerate, like P&G. In 1970, Clorox introduced Clorox 2 all-fabric bleach. Later on in that period, it acquired a number of brands that remain a part of their portfolio today, including Formula 409, Liquid-Plumr, Kingsford charcoal and developed cleaning products such as Tilex instant mildew remover.[9] It even acquired a ranch dressing that was still new to the market, which was known as "Hidden Valley."
In 1988, Clorox struck a licensing-and-distribution agreement that brought Brita water filters to the U.S.; the company acquired sole control of the brand in 1995 when it acquired Brita International Holdings.[9]
In 1990, Clorox purchased Pine-Sol.[9]
In 1999, Clorox acquired First Brands, the former consumer products division of Union Carbide, in the largest transaction in its history. Such brands as Glad, Handi-Wipes (which First Brands acquired from Colgate-Palmolive several months before the Clorox acquisition) and STP became part of the Clorox portfolio. The First Brands acquisition doubled the size of the company and helped it land on the Fortune 500 for the first time the following year.[9]
During the next decade, the company focused on consumer megatrends that included sustainability, health and wellness, multicultural, and affordability/value.[10] In 2002, Clorox entered into a joint venture with Procter & Gamble to create food and trash bags, food wraps, and containers under the names Glad, GladWare and related trademarks.[11] As part of this agreement, Clorox sold a 10% stake in the Glad products to P&G, which increased to 20% in 2005.[12]
In 2007, the company acquired Burt's Bees.[13] The next year, it became the first U.S. marketer to develop and nationally launch a natural cleaning line, Green Works, into the mainstream cleaning aisle.[5] in 2010, Clorox shed businesses that were no longer a good strategic fit for the company, announcing that it was selling the Armor All and STP brands to Avista Capital Partners.[14] In 2011, Clorox acquired the Aplicare and HealthLink brands, bolstering its presence in the healthcare industry.[15] With about 7,700 Clorox employees worldwide as of Dec. 1, 2014,[1] the company's fiscal year 2014 net sales were $5.5 billion,[1] which ranked #451 on Fortune's 2014 Fortune 500 list.[2]
The Clorox Company currently owns a number of well-known household and professional brands across a wide variety of products, among them:
- Brita water filtration systems[4][16]
- Burt's Bees natural cosmetics and personal care products[4]
- Fresh Step, Scoop Away and Ever Clean cat litters[4]
- Formula 409 hard surface cleaners[4]
- Glad storage bags, trash bags, Press'n Seal, GladWare containers (joint venture with P&G as 20% minority shareholder)[4]
- Hidden Valley dressings, sandwich spreads and condiments, dips and dressing mixes, croutons and salad toppins, side dishes and appetizers[4]
- Green Works natural cleaners[4]
- Kitchen Bouquet, KC Masterpiece, and Soy Vay sauces[4]
- Kingsford charcoal[4]
- Lestoil Heavyduty Laundry / Multipurpose Cleaner[4]
- Liquid-Plumr drain cleaner[4]
- Pine-Sol, Tilex, and S.O.S cleaning products[4]
For historical reasons, and in certain markets, the company's bleach products are sold under regional brands. In 2006, Clorox acquired the Javex line of bleach products in Canada, and similar product lines in parts of Latin and South America, from Colgate-Palmolive.[17]
Clorox's Net Sales (2012–2014)[1]
(Dollars in millions) | 2014 | 2013 | 2012 |
United States | $5,514 | $5,623 | $5,468 |
Sometimes confused with chlorine bleach, household bleach has a completely different chemistry. Household bleach is a chemically-combined oxidizing agent that is used to remove or lighten color. Clorox bleach is derived from sodium chloride – common table salt. Clorox produces household bleach by bubbling chlorine into a solution of water and sodium hydroxide. During this process, the chlorine is converted to a sodium hypochlorite solution.[18] The ingredients in Clorox bleach are water, sodium hypochlorite (used to whiten and kill bacteria), sodium chloride, sodium carbonate (removes alcohol and grease stains), sodium chlorate, sodium hydroxide (removes soils that are fatty, oily, or acidic), and sodium polyacrylate.[19]
Corporate responsibility[edit]
In 2011, The Clorox Company became an early adopter of a corporate trend to integrate corporate social responsibility (CSR) reporting with financial reporting. The company's annual report for the fiscal year ending in June 2011 shared data on financial performance as well as advances in environmental, social and governance performance.[6]
Advertising awards[edit]
In 2012, Clorox "Bleachable Moments," a national television ad campaign targeted to young adults, garnered silver and bronze Clio awards for DDB San Francisco, the agency that produced the ads.[20] Another ad produced by DDB in 2012, a suggestive Liquid Plumr spot titled "Double Impact," was named Advertising Age's Viral Video of the Year in the :60 spot category.[21]
Allegations of sexism[edit]
During 2006 and 2007, a Clorox commercial that aired nationally showed several generations of women doing laundry. The commercial included the words "Your mother, your grandmother, her mother, they all did the laundry, maybe even a man or two." Feminists criticized the commercial for insinuating that doing laundry is a job for women only.[22][23]
The Clorox slogan, "Mama's got the magic of Clorox," was criticized on similar grounds.[24] The slogan first appeared in a Clorox commercial in 1986.[25] A modified version of the commercial ran from 2002 to 2004.[26]
In 2009, Clorox received complaints of sexism for an advertisement that featured a man's white, lipstick-stained dress shirt with the caption, "Clorox. Getting ad guys out of hot water for generations."[27] The ad, and others, were produced expressly for the television program Mad Men, capitalizing on "the show's unique vintage style to [create] a link between classic and modern consumer behaviors."[28]
Questioned product claims[edit]
In 2008, the Sierra Club endorsed the Clorox Green Works line. Sierra Club Executive Director Carl Pope stated that one of non-profit organization's "primary goals is to foster vibrant, healthy communities with clean water and air that are free from pollution. Products like Green Works help to achieve this goal in the home." The Sierra Club also partnered with Clorox "to promote a line of natural cleaning products for consumers who are moving toward a greener lifestyle."[29] The partnership "caused schisms" in the club, which contributed in part to Pope's decision to resign.[30]
Also in 2008, the National Advertising Division told Clorox to either discontinue or modify its advertisements for Green Works on the grounds the cleaners actually do not work as well as traditional cleaners, as Clorox had claimed.[31]
In 2009, Clorox received further criticism for its Clorox Green Works line, regarding claims the products are environmentally friendly.[32] Several Clorox Green Works products contain ethanol, which environmental groups state is neither cost-effective nor eco-friendly.[32] Many Green Works products also contain sodium lauryl sulfate, a known skin irritant.[32] Some have also questioned whether or not the Clorox Green Works line is greenwashing, as Clorox's "green" products are far outnumbered by their traditional products.[33] Environmentalists have asked, "Why sell one set of products that have hazardous ingredients and others that don't?"[33]
- ^ a b c d e f g h i j "Consolidated Statement of Earnings, The Clorox Company". Yahoo Finance. December 4, 2014. Retrieved 16 December 2014.
- ^ a b "2014 Fortune 500". Retrieved January 19, 2015.
- ^ "Clorox Company (The) Stock Report". NASDAQ.com. Retrieved 28 February 2014.
- ^ a b c d e f g h i j k l m "Our Brands". The Clorox Company. Retrieved 28 February 2014.
- ^ a b DeBare, Ilana. "Clorox introduces green line of cleaning products". SFGate.com. Retrieved 28 February 2014.
- ^ a b Clorox company history, page 1
- ^ a b Clorox company history, page 3
- ^ a b c d "The Clorox Company Heritage Timeline". The Clorox Company. Retrieved 22 February 2014.
- ^ "Clorox Identifies Four Mega Trends For Hispanic Consumers". The Shelby Report. Retrieved 22 February 2014.
- ^ "Clorox and P&G Plan Joint Venture for Glad Products". New York Times. Retrieved 22 February 2014.
- ^ "Clorox and Procter & Gamble Announce Increased P&G Investment in Glad Products Joint Venture". The Clorox Company. Retrieved 22 February 2014.
- ^ "Clorox To Pay $950 Million For Burt's Bees". Environmental Leader. Retrieved 22 February 2014.
- ^ Coleman-Lochner, Lauren. "Clorox to Sell Auto-Care Businesses for $780 Million,". Bloomberg News. Retrieved 22 February 2014.
- ^ Brown, Steven E.F. "Clorox buys Aplicare and HealthLink for about $80 million". San Francisco Business Times. Retrieved 22 February 2014.
- ^ Carr, Coeli. "Pouring It On". Time.com. Retrieved 26 February 2014.
- ^ Clorox press release, December 20, 2006
- ^ "The Facts About Bleach". factsaboutbleach.com. Retrieved 26 February 2014.
- ^ "Ingredients Inside". The Clorox Company. Retrieved 26 February 2014.
- ^ "CLIO Award: Clorox – "Daddy" – DDB California". AdForum.com. Retrieved 21 February 2014.
- ^ "Advertising Age Viral Video Awards". DDBNorthAmerica.com. Retrieved 21 February 2014.
- ^ Wallace, Kelsey (August 31, 2009). "Mad Men's Portrayal of Sexism Seeps Unironically into its Commercial Breaks". Bitch magazine. Retrieved February 5, 2010.
- ^ "Clorox's history of women's unwaged labor". Feministing. Retrieved November 8, 2010.
- ^ If Women Ruled the World: How to Create the World We Want to Live In. New World Library. p. 65. ISBN 978-1-930722-36-1. Retrieved February 4, 2010.
- ^ "Clorox 2 (1986)". ILoveTVCommercials.com. Retrieved 21 February 2014.
- ^ "Clorox Automatic Toilet Bowl Cleaner Commercial – February 11, 2002". YouTube.com. Retrieved 21 February 2014.
- ^ Wright, Jennifer (September 28, 2009). "Clorox "Mad Men" Ads Miss The Target". Brandchannel.com. Retrieved February 5, 2010.
- ^ DeClemente, Donna. "Mad Men inspires brands to create some stylish ad campaigns to help kick-off season 3,". Donna's Promo Talk. Retrieved 21 February 2014.
- ^ "Some in Sierra Club feel sullied by Clorox deal". NBCNews.com. Retrieved 21 February 2014.
- ^ Sahagun, Louis. "Sierra Club leader departs amid discontent over group's direction". Los Angeles Times. Retrieved 21 February 2014.
- ^ "NAD Tells Clorox to Clean Up Ads". Environmentalleader.com. August 17, 2008. Retrieved February 5, 2010.
- ^ a b c Tennery, Amy (April 22, 2009). "4 'green' claims to be wary of". MSN. Retrieved February 5, 2010.
- ^ a b DeBare, Ilana (January 14, 2008). "Clorox introduces green line of cleaning products". SFGate.com. Retrieved February 5, 2010.
External links[edit]
- The Clorox Company
- Clorox (consumer products portal)


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Assortment of bandages, including finger tip, gauze pads and fabric wraps for cuts and abrasions in the workplace or home. Packaged for individual use and to replenish first aid stations and kits. Bandages Type: Standard; Material(s): Plastic; Mounting: With Adhesive; Length: 3".
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Fiona's Positively Profesh Dress
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To mark her Mod-iversary and celebrate every contribution she has made to our community, we're dedicating the description of this stunningly chic sheath to Fiona, a Product Manager in our San Francisco office. Whether she's at her desk or out representing the company at events like the ModCloth-hosted Girl Geek Dinner, Fiona is known for showcasing her style-savviness while flexing her problem-solving skills and asserting her tech industry insight. With its structured shape, sleek lines, and intriguing details, including the dynamic diamonds of cobalt at the sides and the elasticized waistband that runs from front to the exposed zipper in back, this charcoal dress by Max and Cleo demonstrates just the work-ready fashion flair that Fiona favors! We wouldn't be surprised to see her modeling this tailored, fully lined piece along with patent flats, a beaded necklace, and simple blazer during an afternoon meeting, then heading out to dinner and drinks in her scenic Pacific Heights neighborhood for a truly fabulous night on the town.
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text:
Code covered by the BSD License
by Jered Wells Jered Wells (view profile) 9 files 611 downloads 4.56
28 Jan 2011 (Updated 15 Feb 2012)
This is a simple utility for making stem and leaf plots output to the command window.
| Watch this File
Plots stem and leaf plot to command window stemleafplot(v) stemleafplot(v,p) STEMLEAFPLOT plots stem-leaf plots of the input V to the command window. Leaf precision may be defined by the user. Note that inputs will be rounded to the nearest leaf unit (http://en.wikipedia.org/wiki/Stemplot). INPUT V : Array of numerical inputs (NaN values are ignored) OPTION P : Leaf precision (defined as integer power of 10) Stem precision (by default) is 10^(P+1). P is automatically rounded at the beginning of the function. Leaf and stem units are printed at the bottom of the graph. Examples: P = -3 rounds V to the nearest 10^-3 = 0.001 P = 3 rounds V to the nearest 10^3 = 1000 [DEFAULT: P = 0] OUTPUT Command window output EXAMPLES % Stem-leaf plot of V with unit precision V = 10.*randn(1,50); stemleafplot(V) % Stem-leaf plot of V with precision of 0.1 V = randn(1,50); stemleafplot(V,-1) % Stem-leaf plot of V with precision of 100 V = 5000.*randn(1,50); stemleafplot(V,2) Jered Wells 01/28/2011 jered [dot] wells [at] duke [dot] edu v1.2 (02/14/2012)
@Jered: ROUNDN is not a default function. It is part of the Mapping toolbox, I think if that constraint is specified on your file description, it would improve the quality of this submission.
farfan: ROUNDN is a default MATLAB function. I'm not sure when it was released, but perhaps your version of MATLAB is older than R2008b? Check out the MATLAB documentation for more details: http://www.mathworks.com/help/map/ref/roundn.html
I tried the example code but got an error.
>> V = randn(1,50); >> stemleafplot(V,-1) Undefined function 'roundn' for input arguments of type 'double'.
Error in stemleafplot (line 55) v = roundn(v,p);
Does this roundn refer to this function?
Does what it says. Through me for a loop until I noticed that the input had to be integers. I'd recommend that you have a rounding operation on the input, and a warning if you think it's that important. That way it avoids confusion.
To get higher precision, I'm multiplying the input by 10^3. This would be a nice second input and then mark the results by how far the decimal point is shifted.
Saved me time from trying to make one and can gives more detail then from a histogram. Seems like Stem and Leaf should be a built-in function though...
John, if you're going to leave one-star ratings on someone's work then it's rude not to say why you're doing so. Jared's function does what it says and it has a help section (although no example). It would be nice if it returned the leaf and stem units. Perhaps it's possible to code it with fewer loops, but I've not looked into that carefully.
John, is there something that can be improved? I am open to suggestions. For the data types specified, the program has worked very well for the test data that I have used.
Cleaned up code and help file Included H1 line Included examples Added parameter to generate plot with user-defined leaf precision
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Now for your favorite western movie or tv villains.The Danby's?Angel Eyes? Liberty Valance?Jack Wilson?
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Lee Van Cleef
People get the government they deserve.
Yul Brenner in "West World". Western Sci Fi.
Hedley Lamarr from Blazing Saddles
________________________________________ "I'm your brother, just make it count."
Gott'a be.......
A real S.O.B - Little Bill from Unforgiven
It is not the function of our government to keep the citizen from falling into error; it is the function of the citizen to keep the government from falling into error. Justice Robert H. Jackson, the chief prosecutor of the surviving Nazi leaders at Nuremberg, Germany.
All great choices, here are a couple more: John Russell as Stockdale, and his band of Marshals from Pale Rider. Richard Boone. After his hero days as Paladin he played an excellent bad guy in Big Jake & Hombre. Bruce Dern was a villain you had to hate when he murdered John Wayne with a shot to the back in The Cowboys.
I don't make jokes, I just watch the government and report the facts. -Will Rogers An appeaser is one who feeds a crocodile, hoping it will eat him last. -Winston Churchill


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Ironically, American officials said the lack of phone and Internet connections at Bin Laden's otherwise new Pakistan compound was a major giveaway.
Read more about how Bin Laden's low-tech lifestyle kept him off the map for more than a decade, but finally caught up with him on our new Tech page.


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Latest From LIGO |
The Web Newsletter |
LIGO-L980098-05-M Volume 3, Number 5 |
May 1998 |
Editor's Note: We hope you'll find this newsletter an interesting and valuable source of information about LIGO activities. |
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text:
New York state has set aside $3 million to provide air conditioners to people with heat-related health problems.
The State Office of Temporary and Disability Assistance said Monday that eligible households must meet income guidelines and have at least one person with a medical condition that makes hot weather dangerous.
People can apply at local social service agencies. Households determined eligible for the Cooling Assistance Program will receive one air conditioner that will be installed at no charge.
Air conditioners will be provided on a first-come, first-served basis.
NY will provide air conditioners under program
Published On: Apr 02 2013 07:16:10 AM EDT
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UAB News
UAB Awarded $11 Million Department of Defense Grant To Study COPD
Researchers from the University of Alabama at Birmingham (UAB) will be leading a multisite study to assess the role of beta blockers in individuals with chronic obstructive pulmonary disease (COPD). This project will be funded by the United States Department of Defense through an $11 million grant.
UAB School of Dentistry to complete high-tech labs thanks to gift from Oral Arts
The University of Alabama at Birmingham's School of Dentistry dedicated the new D. Thomas Winstead Student Laboratory on April 30, giving students and patients a new, cutting-edge technological dental space to enhance training and care.
UAB hires Temple's Mark Ingram as next athletic director
Ingram arrives in Birmingham after serving as the executive senior associate athletics director at Temple. He has deep roots in the south, having played football and worked at Tennessee. He's also spent time at Georgia and Missouri.


text:
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
The analysis of tight protein-ligand binding reactions by isothermal titration calorimetry (ITC) and thermal shift assay (TSA) is presented. The binding of radicicol to the
When a ligand binds to a protein with a single-digit nanomolar or tighter dissociation constant, it is difficult to measure the affinity accurately using isothermal titration calorimetry (ITC) because the titration curve becomes too steep to fit accurately. In such cases, one can measure the displacement of a weakly binding ligand during titration with a strongly binding ligand of interest [
Here, we discuss an alternative method to determine the binding constants of strongly binding ligands – the thermal shift assay – that could be used in addition to the displacement assay. The thermal shift assay (TSA) [
The phenomenon of protein stabilization against thermal denaturation by ligands was shown to be a useful method for determining ultratight binding constants [
An investigation using a combination of DSC, ITC, and TSA of aromatic sulfonamide inhibitor binding to carbonic anhydrase yielded a full thermodynamic picture of the coupled denaturation and binding reactions [
Hsp90 is a molecular chaperone responsible for the correct folding of a large number of proteins. It is one of the most abundant proteins in eukaryotic cells, comprising 1–2% of the cellular protein content under non-stress conditions. Hsp90 is highly conserved from bacteria to humans. In cancerous cells, Hsp90 is essential for tumor progression because the Hsp90 machinery helps to maintain numerous altered or overexpressed client proteins in their active forms. Since multiple oncogenic proteins can be simultaneously degraded upon inhibition of Hsp90 by small molecule inhibitors, Hsp90 has evolved into a promising anticancer target. Various aspects of Hsp90 have been reviewed [
Radicicol, also known as monorden, was originally discovered as an antifungal substance of fungal origin in 1953 [
Carbonic anhydrases (CAs; EC 220.127.116.11) are ubiquitous zinc-metalloenzymes that catalyze the conversion of CO2 to bicarbonate. In humans, 15 different α-CA isozymes have been described, 12 of which have catalytic activity [
Ethoxzolamide is a drug previously used as an antiglaucoma and antibacterial agent and for the treatment of edema. It is one of the strongest known inhibitors of carbonic anhydrase (hCAII
The thermal shift assay method can be applied to atypical dose curves of extremely tight binding reactions when the use of ITC requires displacement titration. The TSA method is limited only by the boiling temperature of water. The method can be used in miniaturized and high-throughput plate formats for almost any protein-ligand binding reaction. Therefore, it could serve as a primary option for the determination of protein-ligand binding constants.
The fluorescence intensity of the probe ANS is dependent on the molecular environment of the anilinonaphthalene group. Upon protein unfolding, a few ANS molecules bind through a combination of hydrophobic and ionic [
The probability of the protein unfolding can be described by the equation:
The ANS fluorescence intensity in the protein denaturation curve can be described by the equation:
Since the fluorescence intensities of proteins with and without bound ligand are equal for both the folded and unfolded protein forms, the following simplification is made:
After applying
The fluorescence of ANS before and after the transition depends on the temperature. Since the ANS fluorescence has curvature as a function of temperature, the fluorescence dependence on temperature (in the absence of the protein unfolding transition) is accurately represented by the quadratic polynomial:
The final formula describing the temperature dependence of fluorescence is obtained by substituting
In previous studies [
Isothermal titration calorimetry measurements of radicicol binding to Hsp90 constructs and ethoxzolamide binding to hCAII yielded very steep binding curves (
Tight ligand binding constants can be determined by carrying out the displacement of a weakly binding ligand [
This value is approximate and significantly lower than the value obtained by the direct ITC experiment. Additional methods were needed in order to determine the compound binding constants with greater accuracy.
These results are similar to the melting of Hsp90 from other organisms. For example, A. Makarov and coworkers determined the transition midpoint of the
Radicicol specifically binds to the ATP site of the N-terminal domain of Hsp90 with a stoichiometry of one radicicol molecule bound to each Hsp90 monomer. The addition of radicicol dramatically increases the Hsp90αN melting temperature by 15 ºC or more, depending on the ligand concentration (
The addition of radicicol concentrations greater than the protein concentration yielded a single melting transition. However, addition of concentrations of radicicol lower than the protein concentration yielded a profile that is split into two melting transitions. The first transition, the melting transition of free Hsp90αN, occurred at a lower temperature with the temperature midpoint being essentially independent of the ligand concentration (
There is a possibility, raised in the literature, that radicicol binds covalently and irreversibly to the protein [
Similar splits of ligand-bound and free denaturation transitions were observed with ethoxzolamide binding to recombinant human carbonic anhydrase II.
Curves in
Plots of the melting temperature as a function of added ligand at three protein concentrations are shown in
The melting temperatures obtained at various heating rates are shown in
The thermal shift assay helped conclusively determine the Hsp90-radicicol dissociation constant to be about 1 nM, while several ITC approaches yielded the values between 10 and 0.01 nM. Application of both methods is important where greater precision in the determination of the dissociation constant is important.
The determination of ligand binding constants ranging above 108 M−1 is a difficult task. Isothermal titration calorimetry cannot accurately determine binding constants in the single digit nanomolar range or below by direct titration, and displacement titration of a weakly binding ligand is required [
The binding constant of ethoxzolamide to hCAII determined here by TSA (
Determination of binding constants by observing thermal denaturation of the protein at subsaturating ligand concentrations was proposed by Brandts and Lin [
Our previous study of carbonic anhydrase using ThermoFluor® (TSA) [
The entire phenomenon may also depend on the kinetics of binding and denaturation, the rate of heating, and the reversibility of the processes. The process of protein denaturation was dependent on the protein concentration and on the rate of heating, indicating that full equilibrium was not achieved in each experiment. The unfolded protein probably aggregated. However, the demonstration that the binding constant determined did not depend on the protein concentration or the rate of heating confirms the validity of the method in determining tight binding constants.
The application of the TSA method to two unrelated protein-ligand pairs where ligand-free and ligand-bound protein fractions denature separately further extends the applicability of this method for the determination of tightly binding ligand dissociation constants.
Radicicol was purchased from A.G. Scientific, Inc., dissolved in DMSO at 50 mM, and stored at −20 ºC. Radicicol concentration was determined spectrophotometrically using an extinction coefficient of 14,700 M−1cm−1 in methanol at 265 nm [
The gene encoding full-length human Hsp90α protein was purchased from RZPD, Deutsches Ressourcenzentrum für Genomforschung GmbH (Germany). For protein expression, the
His6-tagged Hsp90αN protein was expressed in the
Recombinant human carbonic anhydrase was expressed in
The recombinantly produced protein molecular weight (MW) was determined by a Q-TOF Ultima Global mass spectrometer ("Micromass," Manchester, UK), electrospray ionization, positive (ESI+), capillary OD=90 μm, ID=20 μm, injection speed=0.5 μL/min. Protein solution was diluted with the same volume of acetonitrile solution containing 1% formic acid. MS spectra were processed with MassLynx 4.0 software. Solutions of Hsp90αN with radicicol were incubated under the same conditions as the solutions used for protein denaturation experiments. Hsp90αN solutions were then analyzed by MS to test for covalent modifications of Hsp90αN by radicicol, since it was reported that in the presence of high concentration of reductants such as dithiothreitol (DTT), radicicol was unstable and covalently modified [
The protein solution (2–5 μM) was loaded into the VP-ITC isothermal titration calorimeter (Microcal, Inc.) cell (about 2 mL, cell volume about 1.4 mL). The titration syringe (250 μL volume) was filled with 20 to 50 (usually 40) μM ligand solution. Titrations were carried out using 25 injections of 10 μL each, injected at 3 to 4 minute intervals. Stirring speed was 400 rpm. Titrations were carried out at constant temperature in the 13 – 37 ºC temperature range. Ligand solution was prepared in the same buffer as protein solution containing the same concentration of DMSO (usually 1%).
The thermal shift assay was performed using the iCycler iQ Real Time Detection System (Bio-Rad, Hercules, CA), originally designed for PCR, and the ISS PC1 spectrofluorimeter with a temperature-controlled water bath. The temperature was measured inside the cuvette using a TFN520 thermometer (Ebro Electronic GmbH & Co KG, Germany) with an error of ±0.2 ºC. Protein concentrations were measured spectrophotometrically (ɛ280 (Hsp90αN)=15,930 M−1cm−1, ɛ280 (hCAII)=50,420 M−1cm−1). Protein and ligand concentrations and buffers are shown in the figure legends. DMSO was added to make up 1% (v/v) of the solution in each measurement. Protein unfolding was monitored by measuring the fluorescence of the solvatochromic fluorescent dye Dapoxyl™ sulfonic acid sodium salt (iCycler) or ANS (ISS PC1), both at 50 μM. The total volume of the reaction was 0.01 mL (iCycler) or 3 mL (ISS PC1) using a covered cuvette to prevent evaporation. Samples in the iCycler were overlayed with 2.5 μL of silicone oil DC 200. The assay was performed in 96-well iCycler iQ PCR plates. Samples in ISS PC1 were excited with UV light of 380±5 nm, and the ANS fluorescence emission monitored at 510±5 nm. Heating of the samples was carried out at a speed of 0.5, 1, or 2 ºC/min.
DSC experiments were carried out using an MC-2 Scanning Calorimeter (MicroCal, Inc. North Hampton, MA). Hsp90 samples contained 120 μM Hsp90αN, 0 to 360 μM radicicol, 50 mM Hepes buffer, pH 7.5, and 100 mM NaCl. Carbonic anhydrase samples contained 100 μM hCAII, 0 to 1 mM ethoxzolamide, 50 mM sodium phosphate (pH 7.0), 50 mM NaCl, and 2% DMSO (cuvette volume 1.2 mL). A scan rate of 1 ºC /min was applied.
The thermal shift assay is a good way to measure tight ligand-protein binding constants. The assay can be performed in high-throughput fashion using a plate format even at subsaturating ligand concentrations. It is important to check and confirm ITC results of tight binding reactions by an alternative method such as TSA.
The project was supported in part by the Lithuanian Science and Studies Foundation (N-06/09), Lithuanian Government, and EEA Grants 2004-LT0019-IP-1EEE. The authors thank Johnson & Johnson Pharmaceutical Research & Development, LLC, PA, USA, for the donation of the ISS PC1 spectrofluorimeter and Prof. Vincent J. LiCata, Louisiana State University, LA, USA, for the donation of the MC-2 Scanning Calorimeter, MicroCal, instruments used in this study. The authors also thank UAB "Sicor Biotech," Vilnius, Lithuania for carrying out the mass spectrometry experiments.
1,8-anilinonaphthalene sulfonate;
dimethyl sulfoxide;
differential scanning calorimetry;
bovine carbonic anhydrase II;
recombinant human carbonic anhydrase II;
heat shock protein 90;
isothermal titration calorimetry;
thermal shift assay
Panel A. Isothermal titration calorimetry data from radicicol binding to Hsp90αN. Upper graph – raw ITC data, lower graph – integrated ITC data with the curve fit to the standard single binding site model. The cell contained 4 μM protein, while the syringe contained 40 μM radicicol in the same buffer - 50 mM sodium phosphate, pH 7.5, 0.5% DMSO, 100 mM NaCl, at 25 °C. Panel B. Isothermal titration calorimetry displacement assay. All conditions are the same as in Panel A, except there was 1 mM compound 1 added to the calorimeter cell. Panel C. Chemical structures of radicicol and compound 1. Panel D. Isothermal titration calorimetry data from ethoxzolamide binding to hCAII. The cell contained 7 μM protein, while the syringe contained 100 μM ethoxzolamide in the same buffer - 50 mM sodium phosphate, pH 7.0, 0.5% DMSO, 50 mM NaCl, at 37 °C.
Denaturation profiles of Hsp90αN or hCAII in the presence of inhibitors. Panel A. Hsp90αN (14 μM) in 50 mM Tris buffer, pH 7.5, with added radicicol: ▪ - 0 μM, ▴ - 2 μM, × - 3 μM, Δ - 6 μM, ○ - 10 μM, + - 20 μM, and − - 50 μM. Panel B. hCAII (5 μM) in 50 mM phosphate buffer, pH 7.0, containing 50 mM NaCl, with added ethoxzolamide: ▪ - 0 μM, ▴ - 1.5 μM, × - 2 μM, Δ - 3 μM, and ○ - 50 μM. Increased inhibitor concentrations raise the melting temperature of both proteins by more than 10 ºC, depending on concentration. Two transitions are observed when both free and ligand-bound proteins are present. Heights of both transitions are additive and proportional to the fraction of saturation by the inhibitor. The data points represent experimental observations while the lines are fit to
The protein melting temperature dependence on inhibitor concentration. Panel A. Hsp90αN with radicicol (from the melting curves in
The dependence of the melting temperature of Hsp90αN on radicicol concentration. The data points show the melting temperatures of ligand-bound components at three protein concentrations: ▪ - 4.1 μM, Δ - 7.5 μM, and • - 14 μM. The
The dependence of Hsp90αN melting temperature on radicicol concentration with various rates of heating. Data points show the melting temperatures of ligand-bound and free components at three heating rates: ▪ - 2 ºC/min, Δ - 1 ºC/min, and • - 0.5 ºC/min. Lines are drawn according to
Thermodynamic parameters of free and ligand-bound unfolding of Hsp90αN (14 μM) and hCAII obtained by fitting to the data in
[Ligand], μM | Δ |
Uncertainties- | ±1.2 | ±1.2 | ±140(TSA)
±0.15 |
Hsp90αN (14 μM) with radicicol (TSA) | |||||
0 | 51.6 | – | 670 | – | 0 |
2 | 52.7 | 61.1 | 650 | 610 | 0.15 |
3 | 52.5 | 61.0 | 610 | 610 | 0.22 |
6 | 53.0 | 61.8 | 600 | 600 | 0.44 |
10 | 51.4 | 63.6 | 610 | 610 | 0.74 |
20 | – | 64.9 | – | 870 | 1 |
50 | – | 66.9 | – | 900 | 1 |
Hsp90αN (120 μM) with radicicol (DSC) | |||||
0 | 48.2 | – | 290 | – | 0 |
60 | 48.6 | 63.4 | 302 | 283 | 0.5 |
360 | – | 66.9 | – | 477 | 1 |
hCAII (5 μM) with ethoxzolamide (TSA) | |||||
0 | 57.8 | – | 690 | – | 0 |
1.5 | 58.1 | 63.9 | 720 | 750 | 0.3 |
2 | 58.8 | 64.6 | 660 | 720 | 0.4 |
3 | 59.8 | 64.6 | 610 | 740 | 0.6 |
50 | – | 68.2 | – | 780 | 1 |
hCAII (100 μM) with ethoxzolamide (DSC) | |||||
0 | 56.5 | – | 570 | – | 0 |
22 | 56.5 | 66.5 | 490 | 890 | 0.2 |
50 | 56.4 | 66.9 | 420 | 860 | 0.5 |
1000 | – | 69.4 | – | 790 | 1 |
Parameters used to fit


text:
Adam Lambert, Sarah Palin Won't Shmooze at 'Tonight'
No Glambert for Sarahcudda
Sarah Palin and Adam Lambert are both confirmed to appear on the same episode of 'The Tonight Show with Jay Leno' when he returns to prime time after the Olympics, but don't expect to hear a duet.
"The producers would love to have Sarah and Adam meet face-to-face on camera. It would be ratings gold. However, that is not going to happen," revealed a TV insider about the March 2 meeting. "Both camps have made it clear they have no interest in meeting backstage or onstage."
That's too bad. They would be amazing belting out the Donny and Marie classic, 'A Little Bit Country, A Little Bit Rock 'n' Roll.'"
Jon and Kate ... Again?
Sources close to the Gosselin family tell me that since the media spotlight has disappeared and fancy party invites have stopped arriving, Jon Gosselin has realized just how much he misses his old life with Kate and all eight of his children.
"Jon is tortured by regret and wishes he could turn back the clock," a friend of the octodad tells me. "Jon thought that after Kate, he would be more successful with hot celebrity women and movie roles pouring in. He even thought he would become a fashion designer. But now that his 15 minutes of fame are over, he is left alone to wonder 'What have I done?'"
And although Jon is finding out the grass isn't always greener, he better get used to his side of the lawn, as my sources tell me "Kate would never take him back now. There is way too much water under the bridge."
Thankfully, though, a rep for Jon tells me he will not be reuniting with Kate.
Room Service Prepares for Big Chefs
The center of the food universe this weekend will be at the Loews Miami Beach and the Gansevoort Hotel as hundreds of the world's best chefs gather for the 9th annual Food Network South Beach Wine & Food Festival.
The two best hotels will host -- among others -- Emeril Lagasse, Bobby Flay, Paula Deen, Rocco DiSpirito and Guy Fieri, who will be throwing the closing party of the weekend at the Gansevoort.
Good thing the room service at both properties is fit for a king -- or queen Rachael Ray.
Got a tip for Rob? Email him at email@example.com
Follow Rob on FaceBook: www.hs.facebook.com/rshuter
Who's Rob Shuter? Read His Bio
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- Thursday 25 FebruaryBy JohnLow Ranked Vote downVote upReport this
Morals? Just like doing sex scens on live tv! Reality? lol Im no fan of Palin but you got to be kidding...
- Thursday 25 February
John she has no morals, sex is not the only way to be morally inept.
- Thursday 25 FebruaryBy llednezHighest Rank Vote downVote upReport this
Of course they won't meet face to face. Adam could talk circles around that idiot Palin. Nothing she says would be of any value, she's just a hypocritical religious loon.
- Thursday 25 FebruaryBy T walkerLow Ranked Vote downVote upReport this
Wow - how much more threatened by Palin can you people be!! I love it...she's got you on the run!!!
- Thursday 25 FebruaryBy SndncZeetHighest Rank Vote downVote upReport this
T walker - "Threatened" by Palin? ROFL Oh please, a flea would instill more fear than that clueless moron Palin. How long have you been living in that scary dreamworld of your's? lol
- Thursday 25 FebruaryBy Mike
Yeah, out me on with that gold=digging quitter, Palin. I'll tell her "where the dog died." If Jay "puffballs" her, I'm done with him.
- Thursday 25 FebruaryBy JetHigh Rank Vote downVote upReport this
Nice! That sounds just about right. LOL! Palin just doesn't have any brains except for doing manipulative, vicious stuff - thta is where she excels. Adam, the dude can sing his face off and he's articulate. Quite a contrast.
- Thursday 25 FebruaryHighest Rank Vote downVote upReport this
I don't not fear her I am insulted by her trying to say she represents the women in our country. We are not empty headed twits willing to dump our special needs children for our own personal ego agendas. We are not quitters, we do not offer our children up as props for our own gain. I find it totally criminal that our young women are being brain washed and manipulated by the rabid right to think that the low life trashy behavior Palin has shown is the right way to be, that the middle school cheerleader, drama queen mentality shown by Palin is being reinforced as what woman should be.
Our young women should be shown that honorable, strong, responsible, loyal, educated, professional (skip the stupid wink wink gotcha idiocy)That we do not have to act all cutsy and dingy to get attention.
- Thursday 25 February
with any luck at all, Lambert can do a chorus of the Heart song "Saracuda"
"you'd like to be the God for us, now wouldn't ya....ohhhhhhhhh Sara Sara Saracuda" - Thursday 25 FebruaryBy DavidLow Ranked Vote downVote upReport this
Who is Adam Lambert?
- Thursday 25 FebruaryBy chip
John M heed your own words ...keep your opinions to yourself
- Thursday 25 FebruaryBy Dean
Jay Leno and the Tonight show will be just fine. Don`t like the show? Then don`t watch. Now isn`t that simple?
- Thursday 25 February
A pit bull with lipstick is nothing more than a bully trying to look pretty who would attack and maim for no reason at all other than it want's to.
- Thursday 25 FebruaryBy carl
Palin has far too much class to be on the same show as that Freak Of Nature
- Thursday 25 FebruaryBy lauraHigh Rank Vote downVote upReport this
You're so funny Carl. You must have missed my earlier definition of "Freak of Nature." It is equivalent to being otherworldly creative and gifted. Many thanks for placing Adam in the same category as Jimmy Morrison, Prince, David Bowie, Madonna, Lady Gaga, ACDC, Alice In Chains, KISS, Elton John, Michael Jackson......................and the list goes on..............as will this young super star!
- Thursday 25 FebruaryBy SndncZeet
Palin has no class whatsoever. She's a religious hypocrite who finds it's entertaining to shoot defenseless animals from a chopper and watch them bleed to death. Oh yeah, that's class. NOT. Get some help, carl, you're obviously mentally unstable.
- Thursday 25 FebruaryHighest Rank Vote downVote upReport this
frankly I don't like Jay because I find his humor lacking, Palin isn't on a political spectrum I agree with,i find her intellgence questionable but not unlike every other polititian. As for people pointing out how she wrote on her palm in reality to me its just a more primative version of a teleprompt. Lambert is an entertainer as far as they go they usually do outrageous things to get attention,its just with the way society is now that you have to go a little far sense we're pretty much desensitized. Look at the rat pack they're loved and from a much more "innocent" time but they were boozing womanizers. Elizabeth Taylor was a class act yet she was a rough dame with a reputation. So what Adam does is his business I don't give it any attention cause I don't care. See how easy it was for me to put my views without insulting other posters?As a christian I work the other angle "love thy neighbor" I don't judge, that's God's job.
- Thursday 25 FebruaryBy Grant
Your response is exactlly why we have a person in the white house (can we still call it that) who has no idea what is happening, because he is black and wasn't someone else. You crazy lib's need to stop thinking because someone is not whte or a male that they are better and smarter.
You have no idea what palin is like except for the goonie MSNBC, and CNN.
Your adman lambert is loved because he is gay, end of discussion, almost like the so called post turtle we have running this country into the ground. - Thursday 25 FebruaryBy paul
GEEE YO? what the Fuc%^^ is a YO? retart like using Yo" is short for what palin is! so gee YO" can u understand that? Gee YO" if it bothers u so much why don t go after Rush Limpbaugh & little becky? O but I for got They havethe RIGHT to say it cause That retard"
- Thursday 25 FebruaryBy paul
GEEE YO? what the Fuc%^^ is a YO? retart like using Yo" is short for what palin is! so gee YO" can u understand that? Gee YO" if it bothers u so much why don t go after Rush Limpbaugh & little becky? O but I for got They havethe RIGHT to say it cause That retard"
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text:
Five years ago, NFL teams used the Wildcat offense to confuse and wreak havoc. Then opposing defenses figured it out. Last year, the Wildcat was forgotten a little bit as teams like the Washington Redskins, San Francisco 49ers, and Seattle Seahawks ran the read option. Now, though, New York Jets head coach Rex Ryan is claiming that he's going to keep using the Wildcat for some reason.
"Like you guys say, we never used it," Ryan said to reporters, speaking about last season. "So I would say, yeah. I would think that's part of what we do."
The Jets signed Tim Tebow last year, who for all his faults theoretically could've been one of the best Wildcat quarterbacks in the league. But they didn't use him, partly because Ryan was intent on riding the season out with Sanchez and partly because Tebow was really bad every time he was given a chance. And now that Tebow's off to the Patriots and the NFL has moved on, Ryan thinks this is the perfect time to unleash the Wildcat.
Ryan said the Wildcat will continued to be a staple in the league, "for the simple fact that guys are getting these quarterbacks now—these mobile quarterbacks—and the size, speed and all of that kind of stuff, so I do think it's here to stay."
Everyone else disagrees. NFL.com writer Chris Wesseling tweeted this response to the news, which sums up both Ryan's comments and the franchise as a whole.
Wildcat? The rest of the league is playing chess, and Rex is over in the corner with his Lincoln Logs.
— Chris Wesseling (@ChrisWesseling) July 31, 2013


text:
My garminfone reboots when screen is touched (wake). Again comes back to the lock sign. When I touch it, it reboots and this goes on I am unable to use the phone
Have you tried a Hard Reset? Here's how you do it: Turn the power off. If your Garmin-Asus Garminfone is frozen, pull the battery out and reinsert it. Hold the Left D-pad button. Press and hold the Power button until the device turns on. Follow the on-screen instructions to restore the phone. (from KnowYourCell.com)


text:
You have no idea what is going to happen in the future. Teams are going to be better prepared for RG3 next season, just like Cam newton is not having a great year. I will not crown RG3 as an elite QB. Also the probability of RG3 getting injured regularly is high because of the way he is been used. In 2-3 years we will know if RG3 is an elite QB. Anything can happen in the NFL, I hope RG3 has some success, I like the way he plays, he is fun to watch.
Cam Newton has been amazing the second half of the year. One of the best kept secrets in the NFL right now.
I was going to laugh and say thank God RGThreesus isnt in our division. Then I remembered our record against the damn Rams this season.
The Rams are going to model their team exactly like the 49ers and Seahawks, albeit just a tad quicker because they have so many high round draft picks. Don't be surprised if they're competing for the West crown next year.
Teams have not figured out RG3 the entire year. Teams figured out Cam after game 6 last year, just look at the stats after week 6. Now Cam has adjusted as is playing much better. RG3 is not elite yet, but the probability is really high.
Brockers Jenkins Quick Givens Richardson I like these guys. Not disappointed in our choice. Will there always be a "what if"? Yeah, but I really like who we got and there's no reason to look back and cry now. We got some players that will be very solid in the future.
But you've been saying that the Rams need an elite QB, and neither Wilson or Kaepernick are elite. Hell, they're not even great, but they are very good QBs who run their offenses efficiently and nearly mistake free, which, when you have defenses like the Seahawks and 49ers, that's really all you need. And I think Bradford can perform just as good, if not better than Wilson and Kaepernick should the Rams get him some pieces on offense.
I still have faith in Bradford, I loved him at OU and he has bounced back nicely after a terrible 2nd year...just need to get him some weapons
RG3 was able to lead WAS to a divsion title. Bradford has not even lead his team to a winning season in THREE YEARS. BIG mistake by the Rams. Plus the picks they get from Washington will be middle round now. So for giving up an elite QB the Rams get: Micheal Brokers ( decent starting DT) Janoris Jenkins (decent starting CB) 2013 #22 pick - Eric Fisher ( OT) 2014 #28 pick - possible starter So the Rams get 3 starters and probably a possible 2nd stringer. None are REAL impact players.
Fair enough. Let's revisit this thread once the Redskins playoff run is over. Then we will know if he is anywhere close to elite.
The Redskins only needed a legit franchise QB to be a contender everyone knew that....While the Rams on the other hand needed a lot more help which they got...
4 years after that SB. So the statement "there's no chance that a team can win a SB without an elite QB" is false. Players are dynamic and change. 2007 Eli was not elite. It doesn't matter if 2011 Eli was elite. The fact is, in today's day and age, a team won the SB with a QB who wasn't elite. It's possible.
I agree. It's so subjective. I also dislike how a lot of people will say 'so and so is elite now that he won a SB.' They use that to support their claim that you need an elite QB to win the SB.
he was elite in his playoff run and the superbowl in 2007. Look at the stats. It may have been the beginning of his eliteness, but he was elite.
i care. real ram fans care. Sam is the second coming of Alex Smith. The faster the rams realize this the better.
So then what you're saying is all you need is a QB who can be elite for 4 games. Gotcha. Bradford could do that.
look what Eli did AFTER the first Superbowl. He has been elite from that time on. Its not about winning 4 games in a row. Bradford would have to win 4 games in a row against the best (playoffs). Thats what Elite QB's do. Bradford cant.
People said the same thing about Manning. They wanted him benched. I'm saying the whole thing about "He's not elite, he can't win a SB" has been proven untrue. Players can improve.
It is too early to tell. Unless the Redskins end up winning the Superbowl this year, the football world is gonna need some more time to know for sure. I can't remember specifics because I don't follow the Rams that closely, but hasn't Bradford had some injury issues (shoulder) as well in his career?
Superbowl XXXV Trent Dilfer 12/25, 153 yds and a TD, not brilliant stats, its definitely not Elite. Yet the Ravens won the Superbowl 34-7. Yes the game is different now. But Alex Smith would have been in the Superbowl last year if it wasn't for special teams. Also in no way is Flacco Elite. He throws a good deep ball but he is way too inconsistent. Also I'm not comparing the two ravens defenses in anyway that Superbowl winning D is arguably one of the best ever. But the Rams are putting together a good D and have the future picks to improve both sides of the ball. It was also the Rams that were the only team to play the 49ers twice this year and not lose either time. Yes they are going to need a new running back, but i think Alfred Morris is proof enough that you can pick up a good running back anywhere in the draft nowadays and the Rams aren't too far away, Armendola is a good slot guy, Givens is a good deep threat, some O-line, a #1 receiver(AJ Green/Julio Jones type), a TE a replacement at RB or to share the load whilst still improving the D and they won't be far away. And they have the draft picks to do it. But yes an Elite quarterback does give you the best chance of winning a Superbowl, but its not necessarily the most important thing. If that was true the Patriots would have 2 more Superbowls, because yes Eli is not better than Brady nor is he Elite, however he still could be with another Superbowl appearance.
Eli's career took one of the most unlikely and positive turnarounds you'd ever see. He's not a typical situation, his first few years were rough, and they were almost ready to give up on him. But at least he showed something. Bradford has yet to show the ability to make plays to actually win a game for you. He's just kinda...there. I brought up the fact during early last year that if the Rams finished bad enough to get the first overall pick, they should absolutely draft Luck. But I didn't understand at that time how good RG3 could be. Now the only reason I'd have hesitation is due to RG3's likely struggles with injury, but the point is that Bradford is not the answer.
You don't know what you're talking about. Bradford had 4 comeback wins this season which would have been 6 if the defense didn't blow the leads on the final drives.
Normally I would agree but the superbowl is about to be played by a 9 game QB and another QB that has rode the success of his defense for the past 4 years and is just starting to look like a great QB. Bad timing lol.


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Full Description: Ulead® DVD PictureShow? Digital Camera Suite is the ideal companion for your digital camera, combining two powerful programs for managing your photos and creating exciting multimedia slideshows. You can use your photos along with your CD or DVD burner to create exciting slideshows that play on your DVD player. Create slideshows using photos or video and add CD-quality audio, your own voice narration, exciting transitions and Hollywood-style DVD menus to present your slideshows. Guided steps and a drag-and-drop interface make assembling slideshows simple. Photo Explorer 8.0 is included to give you everything you need for acquiring, viewing, organizing and enhancing your digital photos.
Keywords: slideshow, authoring, photo, show, photoshow, svcd, presentation, software, graphics, multimedia, editing, retouch, red-eye, reduction, image, resize, email, photos


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Jute Fabric Roll
Bloody Limb Roll
Decorate your haunted house with the spookiest decorations when you have the Bloody Limb Roll. This 20-foot roll features bloodied arms and legs that will go perfect with your other Halloween decor.
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No matter what the breed, your trusty friend can shake it up on Halloween in this awesome Rock N Roll King Dog costume. Women will flock to your four-legged friend so dress well and rock 'n roll on Halloween.
Boney Hands Glow in the Dark 4-Way Fabric
Scare up some Halloween fun when you decorate with this versatile black Bony Hands glow-in-the-dark 4-way fabric panel - use it as a door swag, a window swag, a window valance or a curtain. You can probably imagine even more uses for this fanciful fabric so why not give it a try.
Mini Glitter Gambler Tophat
Roll the dice and let's see who's going to get lucky tonight! Lucky you in this adorable mini tophat !
13' Creepy Curtain
Hang this 13' Creepy Curtain anywhere in your house and take that room to a whole new level of spooky! This grey and white curtain is the perfect addition to any dull room for Halloween.
Creepy Web Curtain
Decorate your haunted house with this Creepy Web Curtain watch as it all comes together. Add some spiders and listen for the screams of approval!
Rockabilly Kit
You can't rock 'n' roll without some awesome accessories. The Rockabilly Kit features a red bandana style headband, bow earrings with dice detail and dice bracelet.
Elvis Grand Heritage White Adult Costume
Long live the King!! Shake, rattle and roll in this ultimate Elvis Grand Heritage White adult costume. This jumpsuit features studded embellishments, matching belt and long red scarf.
Dungeon Skull Border
It's all about the details, so make sure you've got 'em all covered when you decorate with the Dungeon Skull Border. This 100-foot roll features haunting skull graphics.
12' Trick or Treat Burlap Banner
Decorate your Halloween party with the 12' Trick or Treat Burlap Banner. This 12-foot roll of burlap banner features triangular cut pieced with black lettering on them.
Skylanders Night Shift Boxing Gloves
Roll with the punches in the Officially Licensed Skylanders Night Shift Boxing Gloves. Complete your Skylanders Night Shift costume with Night Shift's terrifying punch with these dark blue gloves featuring a white skull detail.
Honest Abe Beard
Take on the roll of one of America's most influential presidents when you complete your Lincoln costume with this Honest Abe Beard. Without this authentic-looking facial hair no one will be able to tell who you are!
Executioner Mid-Size Axe
Heads will roll on Halloween when you suit up for duty and carry your Executioner Mid-Size Axe. This foam axe features a realistic design from the painted handle to the blade.
Inga Blonde Adult Wig
Create or complete your classic character costume with this tradition blonde Inga wig style with bangs and pigtails. Roll out the barrels because you'll have a barrel of fun in this sexy wig!
Robin Caped Costume T-Shirt
America's favorite sidekick is back in the Officially Licensed Robin Caped Costume T-Shirt. If you want to roll as Robin this Halloween, rock this red t-shirt with armor muscle detail, yellow belt, green "R" emblem and black flowing cape.