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More: wBW Reviews Home | wBW Motorcycle Helmet Reviews | Owner Comments (Below)
The Zox Genessis flip-up has a nice surface finish, a comfortable liner and decent face shield. But its other features and functions just aren't quite up to par. The weight of the helmet and ventilation problems also make this helmet difficult to recommend.
Be sure to check out our 3D video and photo of the Zox Genessis helmet in the "World's First 3D Motorcycle Helmet Video"!
We received several emails recently from webBikeWorld visitors, requesting another look at Zox helmets, specifically the Genessis (that's the way it's spelled) RN2 SVS.
Zox is what some might consider a "third-tier" helmet manufacturer, focused more on cost than performance and without the big advertising budgets of the better-known brands.
There's certainly a place for helmet manufacturers in this category and we're just as thrilled to find a bargain as anyone else...as long as the basic quality is there.
Probably the closest competitor to Zox is Vega Helmets and the webBikeWorldVega Summit 3.0 review should also be read by anyone considering a flip-up helmet in this price range.
Two other Zox helmets were previously reviewed on webBikeWorld, back in 2007. The Zox Azuma R, an inexpensive full-face helmet, was reviewed in April of 2007 and it proved to be an excellent value with strong build quality.
But the Zox Nevado R, a flip-up we reviewed in October of that year, had a serious flaw. The locking mechanism for the rotating visor was poorly designed, making that helmet difficult to recommend.
I'm pleased to report that the rotating visor on the Zox Genessis does not have that problem and, in fact, Zox seemed to have gone out of its way to develop what feels like an extra-solid and secure visor locking system for the new helmet, using metal parts instead of plastic.
I'm the default flip-up reviewer around here, but as I've probably mentioned before, in general I'm disappointed that this class of helmet still doesn't seem to be as evolved as it should or could be. Based on reports we've seen from the distributors, flip-up helmets aren't as popular as many had predicted (and hoped), which probably starts one of those vicious circle vortex situations.
In this case, flip-us are more complicated designs, making them more expensive to produce at acceptable levels of quality. So corners are cut -- usually with the design of the vents and venting systems -- and the helmets end up weighing more because less expensive polycarbonate is used and a smaller range of shell sizes are produced.
The greater weight, poor ventilation and increased noise levels all conspire to lead buyers elsewhere, leaving less profit for future development and dampening the motivation to develop better flip-up designs.
That's my theory anyway, based on my experience with many flip-up helmets over the years.
Something else is at work here, and although this may sound trite, the saying "you get what you pay for" seems to be quite appropriate when it comes to flip-up helmets. In that regard, the Nolan N90 (review) flip-up at $300.00 is exactly twice the list price of the Zox Genessis RN2 SVS. But the N90 is worth it, in my opinion, and it is still "the flip-up to beat" in 2010, as I stated in that review.
You'll get better ventilation, lower weight, less noise, higher quality and Italian style and heritage that when tallied up, all makes a big difference. My feeling is that it's money well spent.
But before I get ahead of myself, let's take a look at the Zox Genessis and see how much helmet your 150 bucks will buy.
The Zox helmets we reviewed both had good quality paint that belied their low price. This Genessis is no exception, and the creamy-colored metallic paint seems thick and nicely applied and it has a relatively thick clear coat protective finish.
In fact, if the paint on this example is any indication, then several other helmet manufacturers -- no matter which tier they're in -- could take a lesson from Zox on how it's done.
The overall styling of the Genessis is also appealing, with a modern look and a few sharp character lines that give some relief to the usual drab and too-conservative flip-up profile.
Where the Genessis falls behind is in the fit and operation of a few of the individual pieces. The chin vent is loose and wobbly, as can be seen in the accompanying video. The eye port gasket was also obviously misaligned on this example, which means that the face shield doesn't seal properly, letting in both air and water.
The design of the vents is biased more towards style than function. The top vents have smooth covers lacking any tactile surface that might facilitate their operation by a rider wearing gloves. The chin vent and top vents also have a stiff and balky feel, adding to the woes.
The SVS, or Sun Visor System, operates via a slider on the lower left-hand side of the helmet, but this also has a stiff feel that seems to sometimes catch half-way through its travel on this helmet.
The rotating flip-up visor works very nicely however, and it does have a solid and secure feel. The release is centrally located under the chin bar. Also, the face shield has excellent optical properties, a first defogging position and it rotates crisply through its opening range.
Score: A few good parts and a few not-so-good lead me to give the Zox Genessis a split rating, with an "Excellent" for the paint and rotating visor but a "Neutral" for the rest. See the Summary Table at the end of this page for a description of our rating system.
This Genessis is a size large but fits slightly oversized compared to other flip-up helmets I've tried. I checked the size printed on the helmet and confirmed it with the size listed on the box to make sure it was really a large -- we've had more than one helmet come through here that was mislabeled.
But a large it is, and I'd guess it fits about 1/2 size bigger than I expected, meaning that this one would probably be better suited for a 60-61 cm head than the 59-60 cm listed for a size large on the Zox Helmets website.
The internal shape is a comfortable and adequate neutral though, tending slightly towards the round, so most owners should find a comfortable fit. The helmet is available in sizes ranging from XS to XXL and although the shell sizes aren't listed, I'd guess that two shells cover this range.
The liner and padding feel comfortable with no hard spots and I think that the Genessis is actually one of the more comfortable flip-up helmets I've worn. The liner is removable although no mention is made of this fact on the Zox website (at least that I could find). It attaches with plastic snaps inside and it does seem to be made with good quality both inside and out.
The ear pockets are slightly smaller than average in diameter but adequately deep. A strip of liner material covers the pocket but smaller speakers can be placed behind or on top of it, or it could probably be cut out if necessary.
The shape of the cheek pads and ear pockets somehow prevent me from sliding on my sunglasses, however, once the helmet is on. There's a bit of an irony here because many riders buy a flip-up helmet thinking it will work better with eyeglasses, but in reality I've had more problems with flip-ups and eyeglasses recently than with eyeglasses and full-face helmets.
webBikeWorld Internal Shape Estimator - Zox Genessis RN2 SVS | ||||||
Narrow | Med. Narrow | Slight Narrow | Neutral | Slight Round | Med. Round | Round |
Helmet Internal Shape Examples (see more Motorcycle Helmet Shapes) | ||||||
Profile |
Scorpion EXO-700 |
KBC Tarmac |
AGV Stealth |
Arai RX-Q |
Shoei RF-1000 |
Quantum II |
More information on helmet fit can be found in the webBikeWorld Motorcycle Helmet FAQ page, along with the chart that lists the helmet weights of webBikeWorld reviewed helmets and also by shape on the webBikeWorld Motorcycle Helmet Shapes page.
Score: I'll give the Zox Genessis an "Excellent" rating for comfort and liner materials and padding.
The good news is that the serious safety issue we uncovered on the Zox Nevado R flip-up has been completely resolved on the Genessis...and then some.
The locking mechanism for the rotating flip-up visor on the Genessis feels very secure, unlike the system on the Nevado R which didn't lock at all, meaning that the rotating visor could be easily pulled out from the shell.
The system on the Genessis uses mostly metal parts, with a "claw" in the visor that grasps a metal post embedded in the receiver on the shell. The rotating system operates smoothly and the visor opens and closes with a secure feel. The centrally located visor release button also works well, so overall the rotating visor on the Genessis is excellent.
The visor also has a strong detent that holds it in the topmost position and there should be no problem with the visor shutting unexpectedly at a gas stop. Remember that flip-up helmets are not designed to be used with the visor raised when you're riding however.
The only fly in this ointment is the fit at the rear of the rotating visor. The sides leave a gap between the visor and the helmet shell, large enough to catch some air and add a bit of noise. The gap and the feel of the visor on the sides detracts from the overall feeling of quality of this helmet.
The face shield on this Genessis is marked as meeting VESC-8 standards. It has a generously-sized lift tab on the left but it's thinner than average at 1.45 mm but it has outstanding optical qualities. It has a small first opening for defogging and a total of 5 detents. It operates with a crisp feel and just a slight amount of twisting, but overall it's a very nice system.
The eye port gasket is a problem however. It appears to have been deliberately designed to be thinner towards the center, probably in an attempt to make sure the face shield fits with even pressure across the front. Correct fitting of the face shield is critical and actually rather difficult for helmet designers.
But the shape of the eye port gasket has the opposite effect on the Genessis and the result is that the face shield doesn't seal correctly against the gasket. This allows water to quickly seep in when it rains.
The face shield is easily removed and replaced via a lever on each side that releases a spring-loaded group of fingers that hold the face shield in place. It probably isn't the most secure-feeling system we've tried but it works and shouldn't pose a problem as long as it is infrequently used.
The chin bar is 120 mm tall, measuring from the bottom to the top of the vestigial breath guard. This inhibits visibility out the bottom of the eye port somewhat and evaluators reported having to push the helmet down on their heads to make up for it. Visibility out the top seems slightly better than average for a flip-up and horizontal visibility is average.
The SVS internally rotating sun visor doesn't fully recede into the helmet, leaving it slightly in the rider's vision when retracted. When engaged, the highly curved bottom edge remains in the rider's line of sight, which limits its usefulness.
Eye Port Visibility Estimator: Zox
Genessis |
Visibility | Poor | Below Average | Average | Above Average | Outstanding |
Top to Bottom | ■ | ||||
Side to Side | ■ |
Score: I'll give the Zox Genessis a "Very Good" rating for the overall quality and operation of the face shield and eye port, and "Neutral" rating for outward visibility.
Just like the Vega Summit 3.0 I reviewed a few weeks ago, ventilation is not the forte of the Genessis. The slippery top vents are stiff and difficult to open and when they are, the air flow they provide is minimal to non-existent.
The problem is the liner, which completely covers the intake and large quad exhaust ports. A simple redesign, perhaps by adding some mesh material inside the helmet, might make a big difference here because the exhaust holes through the EPS appear to be larger than those used in most helmets. But as it stands, the solid liner simply blocks any air flow into and out of the helmet.
The chin vent is no better. Besides the balky operation and flimsy feel of the vent cover (see the video), there are no direct air channels through the chin bar and only a very small amount of air gets through the top of the chin bar. By the way, the helmet comes with a snap-in breath guard that I tried once but doesn't seem to do much.
The design of the helmet is such that a huge amount of air blows up from underneath the chin bar, which makes for very cold and very draughty winter riding. It will probably be less noticed in summer, but having uncontrolled air blowing up on to your face isn't fun, no matter the season.
The rear vent cover is an assembly that snaps into the back of the helmet. Ours is slightly loose and has some gaps around the edges, which doesn't bode well for longevity.
So overall, I'd have to rate the venting system on the Zox Genessis as poor and one of the real letdowns of this helmet.
Opinionator: Zox Genessis Ventilation |
Location | Poor | Below Average | Average | Above Average | Outstanding |
Top/Upper | ■ | ||||
Chin/Face | ■ |
Score: Let down by a poorly designed helmet liner and vent covers, the Genessis rates only a "Poor".
Even with the wind blowing up the front of the helmet and around the gaps at the "ears" on each side of the rotating visor, the Genessis seems to remain relatively quiet.
Nothing extraordinary, mind you, but nothing out of the ordinary either. The vents fortunately don't add much to the sound mix and other than the aforementioned volume of air streaming up from below, the helmet seems to control noise rather well.
I suspect that the air flowing up from under the chin bar redirects air that may have otherwise passed around the sides of the helmet and somehow this seems to control the low frequency booming noises that are commonly heard when riding behind a windscreen.
So overall, I'd rate the Zox Genessis as average to slightly below for noise control. Remember that "average" means "loud" when it comes to motorcycle helmets, so always wear ear plugs!
Opinionator: Zox Genessis Noise Levels |
Location | Very Quiet | Quiet | Average | Loud | Very Loud |
Upper | ■ | ||||
Lower | ■ |
Note that our helmet evaluations are normally a combined effort of several riders over time, on different types of motorcycles with and without windscreens. Evaluators wear correctly fitted, high quality earplugs (even when evaluating motorcycle intercom systems) and (usually) a helmet liner. It is strongly recommended that hearing protection is used when riding a motorcycle. See the wBW Earplugs and Hearing Protection page for more information on choosing and wearing earplugs.
Note also that perceived noise levels will vary, depending on the individual. Noise can be caused by many factors, including helmet fit; the type of motorcycle and windscreen; wind speed and direction and even the type of clothing that is being worn. For more information on helmet noise, visit the wBW Motorcycle Helmet Noise page.
Score: I'll give the Genessis a "Very Good" rating for noise control.
The Zox Genessis is a heavy helmet, weighing in at 1900 grams on the nose (4 lbs., 3 oz.) for the size large. But, it's not the heaviest flip-up we've reviewed -- just average, which isn't saying much for this class and one of the several disadvantages of flip-up helmets in general.
Comparing the Genessis to its nearest neighbors, we have the Vemar Jiano (XL) at 1884 grams; the Scorpion EXO-900 (L) at 1888 grams; the Nolan N103 in size XL at 1891 grams; the HJC FS-Max (XL) at 1911 grams; the ZZeus ZS-3000 in size M at 1924 grams and Version 1 of the Shark voline in size L weighing in at 1928 grams.
Sometimes, excess weight can be fairly well masked by good balance, but the Genessis also feels top heavy, which doesn't help...and the slightly loose fit for its size isn't helping either.
The weight is probably due to the polycarbonate shell, the added weight of the internal sun visor and a sub-optimal design.
All of these weights are available on the wBW Motorcycle Helmet Weights page, along with a chart that lists the helmets by weight and shape on the wBW Motorcycle Helmet Shapes page.
Score: I'll give the Genessis a "Neutral" rating for its weight, typical for a flip-up helmet.
The Genessis meets the U.S. DOT safety standard. It has a one year warranty. The helmet also has a European-style ratcheting chin strap buckle.
Overall Opinionator - Zox Genessis |
...and Pans
With a few improvements, the Zox Genessis might be a much better helmet than it is. In fact, it has the potential to be King (or Queen) of the Flip-ups. It has a very nice surface coating and paint and the style/design is better than most flip-ups. The liner and fit is actually very comfortable and the rotating flip-up visor feels very secure.
But the helmet is let down by some annoying quality glitches affecting every one of the vent covers and a pretty big mistake in covering up the vent openings through the EPS liner inside the helmet.
The internally rotating sun visor could also use some improvement by eliminating the severe curvature along the bottom edge and the helmet needs to go on a diet.
So overall, the Genessis just doesn't do anything for me. The flip-up to beat for 2010 is still the Nolan N90 -- admittedly twice the price of the Genessis. But I can't see the point in trying to save money if it means having to make this many compromises.
Product Review: Zox Genessis RN2 SVS Helmet |
Buy Your
Zox Genessis Helmet
as low as $130.00!
Manufacturer: Zox Helmets | List Price: $149.95 (Solids); $179.99 (Graphics). |
Colors: Solids and graphics. | Made In: China |
Shell Sizes: 2 (estimated). | Rating: |
Review Date: December 2010 | |
Rating Scale is subjective: Unacceptable, Poor, Neutral, Very Good, Excellent and Outstanding. |
From "L.L." (May 2012): "I bought one of these in May 2011, with a 9/2010 manufacture date. I wanted the red Alize graphics. First thing I noticed was that the black size large helmet I had tried on in the store fit tight, and the graphics version I received felt about 1/2 size bigger, though marked with the same size. However, outside in the Phoenix, Arizona sun, it fit like a charm!
I have been riding it for over a year now, and other than the non-existent top venting (I'm sure the air is going somewhere!) I've been quite pleased. Other than the Zox dropping the red Alize graphics, I'd get another when I need a new helmet.
Not sure if the chin bar is too big or too small. My speedo is "retro" mounted on the tank so it is invisible with pretty much any full-face helmet.
I should also mention that something might have been done to the pads as I don't have any problems with my prescription glasses (either the Ray Bans or clear), except a pair of "hook over the ears" style, which I didn't expect to fit right anyway."
From "M.L." (January 2012): "I recently purchased the Zox Genessis RN2 SVS helmet and have found, despite the good fit, I can't wear it riding. Here's why: The helmet is very loud. I'm used to an HJC full face helmet and the Zox roars.
I tried the Zox with ear plugs but I find that ear plugs isolates me too much from the world.
The chin bar is far too wide. I have a difficult time glancing down at the gauges and mirrors. I have to tilt my head which means it takes longer to check mirrors and gauges and get my eyes back on the road.
I wear glasses and one reason I purchased the modular helmet was to I could slip the helmet on with my glasses on. This doesn't work. In addition, I find that the ear pockets are not the right shape for my glasses. Even if I get them settled in right, not 15 minutes later, they move and are not sitting right on my face. I've never had this problem with the HJC.
One final note concerning the use of the chin curtain and breath shield yesterday in foggy weather. I had the face shield up, chin-bar down and glasses on. Both the breath shield and chin curtain were in place. First breath out, my glasses fogged completely. I removed the chin curtain and tried again. Again, full fog on my glasses.
Remember, the face shield was up. I ended up riding without either the breath guard or chin curtain and had cool air rushing around my head. While this did keep both the face shield and glasses fog free, this is not exactly what I expected out of the helmet."
Editor's Note: I suggest trying to find a pair of ear plugs that will work or you may risk damaging your hearing. All of the webBikeWorld reviewers wear ear plugs at all times, when reviewing helmets and when evaluating intercom systems.
From "T.Q." (August 2011): "I've been browsing your site today as my girl is looking to buy a helmet to start cruising around. I saw your review of the above helmet and thought I'd add a few things.
What I specifically wanted to mention is that Zox appears to have rectified (or maybe it's just a QA issue) the issue with water easily seeping in through the visor. I've taken a couple of highway trips in the rain recently and had no issues with water coming in through the visor.
I would agree that the vents are all but useless and the size of the chin bar can make it difficult to see straight down. On the other hand I have not had any issues with the sun visor getting stuck half way down.
As you mentioned in your review the vent exhaust contraption also appears to be an afterthought on my helmet, with a part of the attachment mechanism misaligned. However, it's been like that since I got it and hasn't deteriorated in any way. Everything else seems to pretty much match my experience. Thanks for all the good info."
From "C.R." (01/11): "A couple of comments about the Zox Genessis RN2 SVS. I bought one of these helmets a couple years ago and found the quality to be very questionable specifically in the chin bar rotating mechanism.
After arriving at work one morning and taking my helmet off I noticed that something looked funny about the chin bar. Upon close inspection I noticed that the left side had pulled away from the helmet shell and that the large silver screw at the pivot point was loose. The screw all but fell out when I started looking at the hinge to see if I could push it back together. Nothing I could do would get the helmet to stay together.
The other issue I had was with the inner plastic liner of the chin bar that the chin curtain snaps to. I had pulled the chin curtain out one day and half of the plastic liner came with it. It appeared to have pulled off of one of the screws that held it on.
What appeared to be an easy fix (remove the screw and put it back through the plastic liner) turned out to be impossible as the screw wouldn't budge. The screw head almost immediately started to strip when I tried to loosen it. To their credit Zox did replace my helmet due to the hinge issue but my confidence in the helmet had already been destroyed.
I still have the new helmet on a shelf in my closet and never wore it again. Now I'm not sure if the one I have is the "RN2" (possibly denoting version 2?) SVS or not. If this is a second version of the Genessis SVS I hope they have addressed the hinge mechanism."


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The Iowa-based institutions of Maharishi Mahesh Yogi have confirmed that at least 130 Indian religious scholars known as "Vedic pandits," who arrived in the U.S. to pursue programmes of religious learning, have gone missing in recent years. One of institutions' officials, however, described some media reports alleging ill-treatment of the pandits as "replete with falsehoods" and "defamatory."
In an email to The Hindu, William Goldstein, Dean of Global Development and General Counsel to the Maharishi University of Management, based in Fairfield, Iowa, said that the Global Country of World Peace (GCWP), the U.S. organisation sponsoring the pandits' R-1 visas and their stay in this country, had not received any prior communication from the scholars before they went "absent without official leave."
It appears that although the transfer programme began in 2006, the bulk of those missing disappeared only in the last few months and there were relatively few absconding in the first seven years of the programme.
Mr. Goldstein said that while they did not know for sure what the pandits were doing after their departure from the Vedic city, he suspected that many of them were "working on simple jobs in restaurants as the ones who have returned or the few we have information or seem to have followed that pattern."
He added that it could be that "someone is misinforming them about the financial opportunities and the legal implications, and their prime motive appears to be to generate more money for their families," and there could be an "organised 'racket' brokering the operation."
Commenting on a report in the Chicago-based newspaper Hi India that pandits who were recruited in India were sometimes as young as 19 years old and that they were held in "makeshift trailer homes guarded by round-the-clock guards," Mr. Goldstein said that report had "ignored several pages of information provided to them" and was "very injurious to the reputation of GCWP..."
However, Mr. Goldstein concurred that the passports of the missing pandits had been handed over, not to the Indian Consulate General in nearby Chicago or to local law enforcement, but to the U.S. Immigration and Customs Enforcement (ICE) authority, as it was a possible violation of federal immigration law.
Although The Hindu also reached out to the Consulate General of India in Chicago and to ICE, neither had provided a response by the time this report went to press.
Quoting unnamed pandits, the Hi India report hinted at other forms of possible ill-treatment of the scholars from India, suggesting that when the management of the Vedic City discovered that some pandits were "desperate to leave the U.S., a mock travel plan is chalked out and the pandits are taken in a van to Chicago's O'Hare airport and dropped at the entry gate. After asking them to wait till the aircraft arrives while the van driver goes around and comes back in a short while."
The report also quoted one pandit who was about to flee, saying, "Some of the strong-willed pandits ran away from the airport for better prospects and the rest of them were picked up by the driver and taken back to the Vedic City."
Mr. Goldstein, however, refuted this claim, explaining, "Every pandit who goes to O'Hare gets on the flight to India that day, except those who go AWOL. Recently, we have been often purchasing the tickets once in Chicago, when we know in advance there are seats on the flight. This is because the past practice of buying non-refundable tickets in advance of driving to Chicago was costing us money for those pandits who went AWOL before getting on the flight."
Keywords: Iowa-based institutions of Maharishi Mahesh Yogi, Global Country of World Peace, R-1 visas, Chicago's O'Hare airport

subset: commoncrawl


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HOW IT WORKS This project, a conceptual artwork by artist Jeff Thompson, allows for 4,200 artists to have their work seen in Artforum magazine. Each participant, paying $1.50 USD and sending their image electronically, will then have their piece, along with all the other participating artists, in an advertisement. Of course, due to the number of artists needed to raise the money for this venture, the images themselves will be quite small... about 3/16" x 3/16", or the size of the image below:
You make a secure payment of $1.50 using PayPal and send an image of your work. The image is shrunk to the 3/16". When $4,200 is raised, the ad is sent to Artforum to be published. The final advertisement and all participating artists will be listed on a revised version of this site after publication. NO ONE IS MAKING MONEY ON THIS PROJECT... WELL, EXCEPT ARTFORUM The $1.50 you will be charged goes 100% to getting your image in Artforum. The price of a full-page ad is $4,200. PayPal takes $0.30 on each transaction, plus a small percentage of the sale price and, depending on location, a currency conversion fee. Therefore, the total price of the image is $1.50.
SIGN UP NOW! You can submit payment via PayPal below, then send your image via email. Please send images sized no larger than 5" x 7", 300 dpi. Be sure to include your PayPal confirmation number with your image. Feel free to buy as many images as you like, though it cannot be guaranteed that they will be placed next to each other. Upon receipt you will be added to the "Arforum Ad Project" email list and updated regularly on the status of the project as well as publishing date.
Already paid and don't know what to do next? Click here. Need more information on the project? Email artforum [at] jeffreythompson.org www.jeffreythompson.org
Already paid and don't know what to do next? Click here. Need more information on the project? Email artforum [at] jeffreythompson.org


text:
Superintendent of Police Ram Nivas Sepat on Monday ordered the arrest of anti-social elements who disturbed the peace and harmony during the election process in the town on Sunday. The rowdies brandished lethal weapons such as swords and iron rods near the polling booth at Government College for Boys, and threatened to kill one Ashwin.Cases have been registered against five persons — Kumar, CMC member, Prasad Babu, Lakshminarayan, Sandeep and Santosh — and , Mr. Sepat said in a release on Monday.
Kumar has been arrested and produced before the court, the SP said.
Keywords: Ram Nivas Sepat, Karnataka Assembly elections


text:
"People often just want to look at me or touch me - some even want to kiss me.
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text:
For Quentin to draw interest, of course, he'll have to start doing better at the plate. He currently owns a .192/.294/.342 slash line with a .637 OPS, exactly 200 points below his career .837 OPS. However, there are no shortage of teams looking for a big bat and an American League team could use Quentin as a DH and give his aching knees a rest. Quentin won't greenlight any old trade to the AL, but he'll think about it for some teams.
A trade could put Quentin in a playoff race but it could also carry financial incentive. Quentin makes $9.5MM this year, $8MM in 2015, and has a $10MM mutual option in 2016. That option does not have a buyout, but a $3MM buyout will trigger if he can somehow play 320 games from 2013-15. It might be a longshot regardless — he is 212 games shy of that number — but he might have a shot of reaching 320 games if he plays DH over the next year and a half.
San Diego hasn't yet approached Quentin about the possibility of a trade, but Heyman writes that they seem to be aware that he's ready to be reasonable should the situation arise.


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Roddy Nov 14, 2012 9:34 AM
Re: add a Sitemap to my iWeb '09 in response to debc214The root folder is the one on the server that contains the folder with your website files and the external index.html file.
The sitemap.xml file should be uploaded using an FTP application. Once you have done this you can test it by entering the URL into the browser to make sure it is in the correct location...
See this page for more info about sitemaps...
... and this one for info about FTP...
debc214 Nov 14, 2012 11:08 AM
Re: add a Sitemap to my iWeb '09 in response to Roddyi feel like i'm missing something here. thanks for taking the time to help....
to back up a bit, i have published my website to a folder, per someone's advice to not use an FTP. i checked and it looks fine (www.calveyautomation.com).
i built my sitemap on the XML-sitemaps site, downloaded it, and then dragged it into my root folder, which i thought i found (after publishing, iWeb gave me the folder location, which specifically said it was the root folder). After dragging the sitemap into the root folder, i tested it using the www.domain-name.com/sitemap.xml (with my domain name entered...), and it takes me to an error page.
i tried moving the sitemap to a folder within the root folder, thinking i had placed it in the wrong spot, but still get an error.
i feel like i'm trying to reinvent the wheel here, but am ovbiously not getting this. and am obviously a complete novice.
thanks for any insights you may have to what i'm doing wrong. especially since you say to upload with an FTP application. lost me there.
Roddy Nov 14, 2012 11:12 AM
Re: add a Sitemap to my iWeb '09 in response to debc214You need to upload the sitemap with an FTP app or your hosting services file manager.
How are you uploading your website files?
debc214 Nov 14, 2012 11:23 AM
Re: add a Sitemap to my iWeb '09 in response to Roddybear with me....
i'm not sure i understand what you mean when you ask "how are you uploadig your website files". i just used the publishing section on iWeb to publish the site. originally i published to the FTP server, but just changed it to a Local Folder.
that's all i've done...
Roddy Nov 14, 2012 11:28 AM
Re: add a Sitemap to my iWeb '09 in response to debc214If you publish to a local folder your website is not published to the server. You have to upload the files with an FTP application after you have published to a local folder!
Do you have an FTP application? If not I would recommend you get Yummy Lite which only costs $1.99 from the App Store...
debc214 Nov 14, 2012 11:40 AM
Re: add a Sitemap to my iWeb '09 in response to Roddywell, seriously i have no idea. how's that for a good answer. it was originally published with the FTP - and i plunked all the info from goDaddy. so i thought that still had something to do with it. no, huh?
then why is the site still up?
i'll get the app now and see how it goes. thanks for all of the help. i'm really not this much of an idiot....
debc214 Nov 14, 2012 12:38 PM
Re: add a Sitemap to my iWeb '09 in response to debc214i can't thank you enough.....got the app, uploaded, fixed, done! and the site is now on google, which is a good thing.
thanks again.


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GigaomCome on, Kobo, a $399 tablet? Really?
E-reading company Kobo plans to launch a $399 tablet. Has it learned nothing from Barnes & Noble's experience? Read more »
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E-reading company Kobo plans to launch a $399 tablet. Has it learned nothing from Barnes & Noble's experience? Read more »
Why is Barnes & Noble extending price cuts on Nook tablets? It may be because the retailer is trying to clear out stock. Read more »
Here's our roundup of the best Black Friday deals on ebooks, tablets and e-readers. We'll update this post throughout the weekend. Read more »
Barnes & Noble's new Nook HD tablets, priced starting at $199, aim to stand out from the pack with reader-centric features and enhanced reading experiences for magazines and catalogs. The company's… Read more »
Google added new Japanese reading features to its ebooks app yesterday and is now selling the Nexus 7, ebooks and movies through the Google Play store in Japan. Kobo expanded to… Read more »
Though most eyes are on Amazon's Thursday press conference, Kobo is angling for early attention with its announcement of two new e-readers and a new 7-inch Android tablet called the Arc… Read more »
Personalized tablet magazine Zite is releasing a large upgrade to its Android app Tuesday afternoon. Among the changes: The end of support for large-screen Android tablets, enhanced sharing options and bug… Read more »
Microsoft invested $300 million in Barnes & Noble's Nook business. As the following chart shows, that probably wasn't a great idea: Production problems, slowing ebook sales and other factors are contributing… Read more »
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Barnes & Noble dropped prices on its Nook Tablets and Nook Color on Sunday, bringing the price of the Nook Tablet 16 GB in line with Amazon's Kindle Fire and Google's… Read more »


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VisionWorks INsight: Webb Simpson
Webb Simpson earned his second win in three starts with a sudden-death playoff victory at the 2011 Deutsche Bank Championship.
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Mackay, Alan L. (1997) Lucretius or the philosophy of chemistry. Colloids and Surfaces A: Physicochemical and Engineering Aspects 129-30 , pp. 305-310. ISSN 0927-7757.
Binder3.pdf Download (130Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/S0927-7757(97)00047-2
A world view deriving from the objective knowledge acquired by the physical sciences is contrasted with the fashionable subjective philosophical view that all systems of thought are equally valid ways of structuring the universe. As Lucretius guessed, atoms are real and are not simply arbitrary constructs to explain the observations. Mathematics and computing have an important role in permitting long and sophisticated arguments to be carried through.
Item Type: | Article |
Keyword(s) / Subject(s): | chemistry, atom, philosophy |
School or Research Centre: | Birkbeck Schools and Research Centres > School of Science > Biological Sciences |
Depositing User: | Sandra Plummer |
Date Deposited: | 19 Dec 2005 |
Last Modified: | 17 Apr 2013 12:32 |
URI: | http://eprints.bbk.ac.uk/id/eprint/287 |
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text: I have been wanting to taste-test some Hawaiian liquor. I have found some at the local liquor store, but being in a small town Virginia, not much of a variety. Also, what they have is only in large (5th) bottles. I would rather have an assortment of small ones to sample. I dont drink much. I think I had 2 or 3 beers last June, and have sampled some local moonshine when there is a new flavor to try, but not really a "drinker" (anymore). I would be more than happy to pay for shipping etc..., if someone could help. Thanks..


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Jewish World Review Dec 16, 2011 / 20 Kislev, 5772 Winning the war against civility By Wesley Pruden
http://www.JewishWorldReview.com |
If only the peasants would sit up and pay attention, the liberal nannies could straighten out "the mess" inWashington overnight.
The nannies, Democrats almost to the man (and woman), are frustrated that the system is working the way it was designed to work -- with arguments (some of them angry), querulous debates and contentious disputation, leading at last to a fragile but workable consensus.
This frightens liberals who have controlled the national debate for lo, these many decades. Some of them prescribe a cure called "civility," which, accurately translated, means "sit down, shut up, and eat your spinach."
A little less debate and a little more acquiescence would, for current example, resolve the debate over extension of the payroll tax cut, set to expire with the year. President Obama is trying to sound enthusiastic about the payroll tax cut extension, making all manner of noise about how he's looking out for "the little people" while the Republicans are only interested in the good fortunes of tycoons who light their illegal Cuban cigars with thousand-dollar bills. But what the president is really enthusiastic about is getting congressional approval of $1 trillion (or maybe more, we're only talking multiples of zeroes) in new federal spending.
The partisan passion could be softened with "civility," followed by a vote approving a continuation of his profligate ways. It's not really rocket science. It's so simple you might think even a cave man (i.e., a Republican) could master it.
Naturally the liberals -- or "progressives," as the people who stunk up the word "liberal" now want to be called -- find others to blame for the parlous condition of the body politic. The monthly Bulletin of the reliably liberal American Association of Retired Persons (AARP) blames air conditioning, cable-TV and Thomas Jefferson. Tamara Lytle, writing in the current issue, makes the case that this array of bad phenomena is responsible for the polarization of the electorate, the "permanent campaign," "citizen shortcomings," the "dysfunctional design" of government by the Founding Fathers, and the rule of the "special interests."
So frustrated are the people, she argues, "that the tea party and the Occupy Wall Street movements have sprung up from opposite ends of the political spectrum to voice public anger at the federal government." If "the system" worked like it once did, and the way it ought to, there would be no public anger because the nannies would have had their way with the spinach. Alas, now a handful of newspapers, cable-TV networks and Internet blogs have given voice to the peasants who once had to tug their forelocks and say "yessir, boss," and no sass or back talk. Such were the "civil" times.
"The system is broken," mourns David Gergen, the director of the Center for Public Leadership at Harvard (naturally). "You'd have to be blind not to see dysfunction in government. And if you're blind, you'd hear it." Actually, blind people are perfectly capable of "seeing" dysfunction, too, and many do. They see dysfunction with a clarity that escapes Mr. Gergen, blinded as he is by politically correct eyesight. Even the blind see that the cure for dysfunction is fewer laws, not more; fewer regulations written by unelected bureaucrats, not more; smaller government, not larger, and more trust in the wisdom of the people, not less. Where you stand always depends on where you're sitting.
The rap on air conditioning, one of the great blessings of the 20th century, is that it enabled the growth of cities in the sunny precincts. Before air conditioning tamed ferocious summers, Atlanta, Miami,Jacksonville, Dallas, Houston andPhoenix were small towns asleep in the sun, where nothing moved in June, July and August. Now they're powerhouse cities, redoubts of Republican voters, and so this is of course bad. As air conditioning spread, many retirees moved south with their conservative politics, making the South even "more . . . Republican and tilting parts of the urban Midwest and Northeast more Democratic," writes Miss Lytle of the AARP. She might have observed, but didn't, that this further increases the obstructionist strength of the liberals in the Northeast, unable to "grow" with the times.
Thomas Jefferson, the Founding Father to whom we all owe the most, arouses liberal ire because he argued against usurping the rights of the states that created the federal union. Like certain of his fellows, Jefferson distrusted the federal government because he knew it would grow too large, become disconnected from the people, and be heir to the arrogance, insolence and prideful haughtiness that is the lot of the unrestrained homo erectus. It's being deprived of this arrogance, insolence and prideful haughtiness that makes the liberal nanny's teeth itch.
Every weekday JewishWorldReview.com publishes what many in in the media and Washington consider "must-reading". Sign up for the daily JWR update. It's free. Just click here. JWR contributor Wesley Pruden is editor emeritus of The Washington Times. Comment by clicking here. © 2007 Wesley Pruden |
Lifestyles |


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Last November, Americans flocked to the polls to vote for change.
A year later, change again drove voters on an Election Day -- with much different results.
The same dynamics that powered President Obama to victory -- frustration with the status quo, economic anxieties, hope that new leadership can bring answers -- now stand as the biggest threats to the Democrats' governing agenda.
One year after Obama's resounding victory, the soaring rhetoric of campaigning has given way to the trench warfare of governing in a polarized country. The president's agenda is now backed up behind a stalled health care bill, even as the calendar prepares to flip into a congressional election year.
Yesterday's election results bring the president's obstacles into harsh focus: All three marquee races on the ballot resulted in party switches. The lesson: Change cuts in at least two directions.
"Anger is far more motivating than satisfaction," said Democratic pollster Celinda Lake. "People were hopeful for change; now they're driving change."
In Tuesday's two-state governor races, independent voters who were critical to the president's winning coalition in 2008 favored Republican candidates by a 2-1 margin. And economic unease -- again, a key factor in Obama's victory -- was foremost on voters' minds, according to exit polls in New Jersey and Virginia.
The mistrust of government Obama capitalized on has only worsened over the past year. Bailouts and stimulus spending may have stopped the economy from collapsing, but voters remain unconvinced -- if not downright angry -- about the nation's economic prospects.
Those factors complicate the president's attempts to enact his ambitious agenda, which -- like most government initiatives -- require money to work.
The Obama administration has sought to cast his top priority of health care reform as part of efforts to curb government spending. But the public hasn't quite accepted that argument, polls suggest.
The case is likely to be a harder sell after yesterday's results, with moderates in both parties viewing the elections as, at least in part, a referendum on the Democratic agenda.
"The public clearly weren't buying what President Obama and Democratic leaders in Congress were selling," Republican pollster Whit Ayres said. "They haven't yet latched on to the Republican candidates, but the door is opened."
Democrats sought to minimize the importance of a handful of local races. Democrats are still poised to pass a health care reform bill in the House in the coming days, and the president's political standing will get a boost with such a victory. The picture is more complicated in the Senate, where moderates hold more sway.
The challenge for Democrats will be to make the case that the change voters supported last year needs a second endorsement next year, said Rep. Chris Van Hollen, D-Md., who heads House campaign efforts for Democrats. That impacts both candidate preparation and the legislative agenda.
"We need to make sure that between now and a year from now we take actions both on the campaign side as well as whatever policy efforts we need to undertake, to make sure that all those voters understand that … the success of the Obama agenda will depend on the turnout at the polls next November 2010," said Van Hollen.


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All signed up JAFWA members are requested to attend.
Between ~12:45 and 3PM we can have a free form event arvo.
It is make your own fun, but we suspect some people will be bringing semi-automatic nerf weaponry, mahjong, video games and even sewing.
After the AGM, the tentative JAFWA program for Saturday 25th August 2012 is below. To be held in the Collins Street Community Center on Collins Street just off Canning Highway in South Perth.
Things of Note:
1) During this evening of August 25, we will be auctioning off the complete set of "Black Lagoon" manga (in English), so bring plenty of money for bids.
2) The Bean Poll for August 18 revealed that attendees wished to keep "Usagi Drop" in the JAFWA program 15 to 1. We haven't been able to fingerprint the one dissenting bean. Most disappointing was that nobody objected to our attempt. As a test of your democratic system this has been a failure.
Perhaps we should next ask is it time to take a breather from "Fairy Tail", as we are reaching a break in the story arc.
3) The 2013 calendar season is just getting underway in Japan. The initial pre-orders can be seen here. As previously, I can order these calendars from Japan if anybody wants some. Pre-orders are the most relieable.
4) I am waiting for reelanime. It will have some good anime movies.
5) Remember to rug up, as our Hall does not have a lot of heating.
All items in the original Japanese language with English subtitles
5:15pm | Sakamichi no Apollon (kids on the slope) | Ep 6/12 | |
5:40pm | Mouretsu Pirates | Ep 14/26 | |
6:05pm | Fairy Tail | Ep 69/? | (v) |
6:30pm | dinner break | ||
7:15pm | door prize drawing, and announcements | ||
7:30pm | Hanasaku Iroha | Ep 3/26 | |
7:55pm | Usagi Drop | Ep 6/11 | |
8:20pm | Jinrui wa Suita Shimashita | Ep 1 | (preview) |
8:45pm | Tiger and Bunny | Ep 21/25 | (v) |
9:10pm | |||
9:20pm | Mawaru Penguindrum | Ep 5/24 | (?) |
9:45pm | Binbougami-ga! | Ep 1 | (v) (preview) |
10:10pm | A Certain Magical Index II | Ep 15/24 | (vn) |
JAFWA Doors Open: | ~4:55 PM |
Program Finishes: | ~11:00 PM |


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JUDE LAW planned a knockout night in Las Vegas Dec. 8: He watched fellow Brit Ricky Hatton battle FLOYD MAYWEATHER JR. at the MGM Grand. But when the actor, who turns 35 Dec. 29, hit club LAX later that night, he had no idea he'd celebrate his birthday too. Says an observer: "He [was] genuinely surprised when the cake arrived." He made a quick recovery—and partied until 4 a.m.
Host FERGIE took a breather with PETE WENTZ (who performed with his band Fall Out Boy) during the Dec. 6 bash sponsored by Avon mark at Avalon Hollywood. Also there: LAUREN CONRAD and EMMY ROSSUM.
KRISTEN BELL looked picture-perfect at new Hollywood hot spot Goa Dec. 6, where she was joined by DAVE ANNABLE and CHACE CRAWFORD.
DEMI MOORE was at the birth of SOLEIL MOON FRYE's 2-year-old daughter. And when Frye's second baby is born this spring? "I hope so," Moore said at the Dec. 6 opening of the Little Seed, Frye's eco-friendly baby store in L.A. Frye assured her: "She's the best birthing coach in the entire universe!"
Just weeks before her wedding to EDDIE MURPHY, TRACEY EDMONDS and 14 gal pals headed to Tao Las Vegas, where they dined then danced until the early morning Dec. 8. Says Edmonds: "I loved every moment."
Beyoncé Knowles and JAY-Z stopped by Dior and Chanel during his 38th-b-day trip to Paris. "It may have been his birthday," says a source. "But it seems she got the presents."
- Contributors:
- CONTRIBUTORS Ashley Williams,
- With Shruti Dhalwala,
- Jennifer Garcia,
- Mark Gray,
- Peter Mikelbank.


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Gunshot victim dies on family's doorstep
Police unsure where the shooting happened
Kansas City, Mo., Police are trying to determine where a man was shot before dying on a family's doorstep in the 100 block of Drury Avenue early Monday morning.
Police said they were responding to the area at about 2 a.m. after someone reported shots fired.
As police were responding a family at 115 North Drury Avenue said a man suffering from gunshot wounds was on their porch.
By the time officers arrived the man died. Authorities identified him as Christopher Jones, 25. Police are now trying to determine who shot him and where the shooting happened.
Anyone with information is asked to call the TIPS hotline at 816-474-TIPS.
Copyright 2013 by KMBC.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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General Question
Is there anything like Coda for Windows?
Asked by dangdang (193
July 24th, 2008
Coda looks like a brilliant peice of software. Is there anything that even comes close to a Text Editor/CSS Editor/FTP Client bundle for windows? (Other then Dreamweaver of course)
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Welcome, Sign In
Venice Carnival Afloat for 2014
Description:Scores of boats crowd Venice's waterways to mark the start of the city's carnival. A pre-Lent festival, carnival means "farewell to meat" and so revelers are treated to free food at the end of the boat parade, according to local resident, Francesco. (0:49)
Source: Reuters
Tags: reuters , reuters news , venice carnival


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No. 23 Cincinnati 26, Pittsburgh 23
Isaiah Pead (pictured) rushed 22 times for 118 yards and quarterback Zach Collaros overcame two interceptions to score twice on the ground to help the Bearcats down the Panthers. With the victory, Cincinnati improves to 7-1 on the season.
Photo: Frank Jansky/Southcreek/ZUMAPRESS.com


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Viewing convention Program information from 2008
Session DetailsMonday, 29 December 713. Intellectual Patronage: Definition, Origins, and Evolution in Britain and Ireland, 1700–1830 9:00–10:15 p.m., Mason B, Hilton A special session Presiding: Clara Tuite, Univ. of Melbourne 1. "Enlightened Zeal: The Hastings Family and Irish Influences in Intellectual Patronage," Shelley Meagher, Queen's Univ. Belfast 2. "The Patron for All Seasons and the Philosopher: William Hayley, William Godwin, and Intellectual Patronage," Mark Crosby, Univ. of Oxford 3. "A Case Study of Literary Patronage in Eighteenth-Century Ireland: Bishop Francis Hutchinson, 1660–1739," Andrew Sneddon, Queen's Univ. Belfast For copies of papers and abstracts, write to firstname.lastname@example.com.
No comments have been posted for this session.
© 2015 Modern Language Association. |


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Cervical Dysplasia
VGX-3100 SynCon® immunotherapy for cervical dysplasia
Phase II
Milestone Expect to initiate a phase III clinical trial 2016 |
VGX-3100 is an investigational DNA immunotherapy candidate designed to treat precancers and cancers caused by human papillomavirus (HPV). VGX-3100 includes plasmids targeting the E6 and E7 proteins of HPV types 16 and 18. Intramuscular injection of the plasmid DNA immunotherapy is followed by electroporation using our CELLECTRA® delivery device.
In a phase II trial, VGX-3100 induced regression of precancerous cervical disease and cleared HPV infection with robust T cell responses.
Development Status
In July, 2014, Inovio completed a randomized, double-blind, placebo-controlled phase II trial of VGX-3100 in women with biopsy-proven cervical intraepithelial neoplasia 2/3 (CIN2/3) associated with HPV types 16 or 18. Meeting its efficacy endpoints, the results of this study represent a significant step toward providing women and physicians a non-surgical treatment for precancerous lesions. VGX-3100 induced regression of a cervical intraepithelial neoplastic process and eliminated high risk HPV infection. These results will guide the advancement of VGX-3100 for precancerous dysplasias as well as HPV-associated cervical, head and neck, and anogenital cancers. Inovio intends to advance VGX-3100 into a phase III clinical trial early 2016.
Disease State
Human papillomavirus (HPV) is the most common sexually transmitted disease. At any given time, approximately 11% percent of the world population is infected with HPV. Roughly 90% of HPV infections are cleared by naturally occurring immune responses within two years.
Persistent HPV infection can lead to dysplasia, or premalignant changes, in cervical cells. HPV types 16 and 18 cause 70% of cervical dysplasia and cervical cancer cases. In just the US and EU5 countries alone, there are approximately 3.4 million incidences of low grade and high grade cervical precancers. All cervical cancers arise from untreated CIN 2/3.
Clinical Trials
VGX-3100 cervical dysplasia immunotherapy
In July, 2014, Inovio completed a phase II clinical trial for VGX-3100, its investigational synthetic DNA immunotherapy for precancers and cancers caused by human papillomavirus (HPV).
The study, designated HPV-003, assessed adult females with CIN 2 or CIN 3 and biopsy-proven HPV 16 or 18. The randomized, placebo-controlled, double-blind study in women evaluated cervical tissue changes after three 6 mg doses of VGX-3100 in a 1 mL intramuscular injection followed by electroporation with Inovio's CELLECTRA® device at weeks 0, 4, and 12. Cervical tissue was examined before starting blinded treatment and 9 months later.
The primary endpoint of this study was to assess regression of cervical lesions from CIN 2 or CIN 3 to CIN 1 or no disease. A secondary endpoint was to clear HPV 16 or 18 in conjunction with regression of CIN 2/3 to CIN or no disease. The study evaluated the efficacy of the immune therapy in patients who received VGX-3100 at 0, 4 and 12 weeks compared to placebo recipients, based on biopsies performed before the blinded treatments and six months after the final treatment.
The study also explored humoral and cell mediated immune responses to VGX-3100 in blood samples taken prior to the first immune therapy dose and periodically thereafter. Cervical samples were analyzed for evidence of immune responses in the cervix at the beginning of the trial and subsequent intervals. Subjects were also monitored for tolerability and safety.
We intend to independently advance VGX-3100 into a phase III registration study with target patient characteristics and a treatment regimen similar to the phase II study. The Company expects to complete its end-of-phase-II meeting with the FDA in 2015 and begin treating women in this phase III study in early 2016.
Study Data
VGX-3100 SynCon® cervical dysplasia immunotherapy
Phase II results: Inovio achieved primary and secondary endpoints
In July, 2014, Inovio reported that in a phase II study, treatment with VGX-3100 resulted in histopathological regression of CIN 2/3 to CIN 1 or no disease, meeting the study's primary endpoint. In the per protocol analysis, CIN 2/3 resolved to CIN 1 or no disease in 53 of 107 (49.5%) women treated with VGX-3100 compared to 11 of 36 (30.6%) who received placebo. CIN 2/3 resolved to no disease in 43 of 107 (40.2%) women who received VGX-3100 compared to 6 of 36 (16.7%) who received placebo. These per protocol analyses were statistically significant.
In addition, the trial demonstrated clearance of HPV in conjunction with regression of cervical lesions. Virological clearance of HPV 16 or 18 from the cervix in conjunction with histopathological regression of cervical dysplasia to CIN 1 or no disease, a secondary endpoint of the trial, was observed in 43 of 107 (40.2%) VGX-3100 recipients compared to 5 of 35 (14.3%) placebo recipients.
As in the phase I study, VGX-3100 also elicited robust HPV-specific T cell responses in the majority of treated subjects. A comprehensive analysis of T cell responses is ongoing.
The treatment was generally well-tolerated, with only administration site redness occurring significantly more frequently in the VGX-3100 group compared to the placebo group in the 7- and 28-day periods following treatment.
Detailed study findings have been submitted for publication in a peer-reviewed journal.
Phase I results
In 2010, Inovio completed a phase I dose escalation study of VGX-3100 delivered with its CELLECTRA® electroporation device. The study treated 18 women who had previously been diagnosed with and surgically treated for high grade cervical intraepithelial neoplasia (CIN 2/3), a premalignant lesion that may lead to cervical cancer, caused by human papillomavirus (HPV) types 16 and 18.
Data from the phase I trial indicate:
- Antigen-specific, dose-related T-cell responses across the three dose groups.
- Unprecedented T-cell responses not achieved by a DNA vaccine or any other non-replicating vaccine platform in humans.
- Strong antigen-specific antibody responses in all three dose groups.
- VGX-3100 delivered using Inovio's proprietary CELLECTRA® intramuscular electroporation delivery device was generally safe and well tolerated at all dose levels.
- There were no vaccine-related serious adverse events. Reported adverse events and injection site reactions were mild to moderate and required no treatment.
These results were published in the peer-reviewed journal, Science-Translational Medicine, in a paper entitled, "Immunotherapy against HPV 16/18 generates potent Th1 and cytotoxic cellular immune responses."
Response rate and magnitude
The paper reported that 78% (14 of 18) of the patients showed antigen-specific cytotoxic T-lymphocyte (CTL, or killer T-cell) responses against at least one of the four antigens (E6 and E7 proteins for HPV types 16 and 18) in the ELISpot assay. At month four, 14 of 18 vaccinated subjects (78%) had developed significant T-cell responses, with positive responses ranging from 100 to over 5000 SFU per million cells. In the third and highest dose group, 83% (5 of 6) had strong T-cell responses, with average responses of 1458 SFU per million cells after three immunizations. This was a 114% increase compared to the intermediate dose cohort average of 683 SFU per million cells (four responders out of six) and a 125% increase compared to the low dose cohort average of 648 SFU per million cells (four responders out of six).
As indicated by the chart and table below, the T-cell levels generated by VGX-3100 far exceed those generated by competitive technologies.
In an extension of this phase I study, T-cell immune data 24 weeks after the last immunization was analyzed among responders. Immune data showed that the responses were still detectable in 86% of evaluable patients, indicating that T-cell responses persisted for at least six months after the final immunization. At the latest time measured, Inovio reported durability of T-cell immune responses over two years in 7 of 8 evaluated patients following a fourth immunization of VGX-3100.
Killing effect
Further tests of T-cell immunity among responders measured the ability of CD8+ T-cells from vaccinated patients to kill cells displaying HPV antigens on their surface: 91% of patients (10/11) who developed T-cell responses showed the presence of CD8+ T-cells capable of this type of killing activity (so-called "killer T-cells"), which is believed to be critical for the treatment of cervical dysplasia and ultimately cancer caused by HPV.
Antibody responses
Overall, 100% of the study participants (18 of 18) reported antibody positivity to at least two vaccine antigens. Specific antibody responses to tumor antigens can function as an important surrogate potency marker for determining the immunogenicity of a vaccine, i.e. the ability of a vaccine to induce an immune response.
Long-term results
In an extension of this phase I study, Inovio reported durability of T-cell immune responses over two years (at the latest time measured) in 7 of 8 evaluated patients following a fourth immunization of VGX-3100.
In general, the durability of these T-cell responses places Inovio's DNA vaccine technology on par with live virus vaccines, but without their various safety and other issues, and substantially exceeds current data from alternative non-replicating vaccine technologies. Furthermore, being able to use multiple immunizations without safety concerns or unwanted immune responses is a notable advantage of Inovio's DNA immunotherapy technology.
More Information
Cervical dysplasia caused by HPV
An estimated 79 million Americans are currently infected with HPV; 14 million people become newly infected each year. Many people who have HPV are asymptomatic and can pass the virus to others without knowing it.
While 90% of HPV infections clear naturally within two years, persistent infections may lead to benign atypical squamous cells of undetermined significance (ASCUS). This condition may possibly progress to the abnormal cells referred to as cervical intraepithelial neoplasia (CIN).
CIN is classified in three grades based on what part of the cervical epithelium is affected by the abnormal cell growth. CIN 1, the least risky type, represents only mild dysplasia and is confined to the basal 1/3 of the epithelium. Of the estimated 1.4 million CIN 1 dysplasias in the US, 35 - 50% are caused by HPV types 6, 11, 16 and 18. CIN 2 is moderate dysplasia confined to the basal 2/3 of the epithelium, while CIN 3 is severe dysplasia spanning more than 2/3 of the epithelium, and may involve the full thickness. Up to 70% of CIN 2/3 dysplasias and cervical cancers are caused by two high-risk HPV types, HPV 16 or 18.
Most low-grade cervical lesions go away in 18 to 24 months without treatment. More severe or "high-grade" cervical lesions usually don't fix themselves without treatment. High-grade cervical dysplasia is more dangerous because it's more likely to lead to cervical cancer.
Patients with early dysplasias must typically endure a stressful "watch-and-wait" period to see if the disease naturally clears on its own. In the case of high-grade dysplasias designated as CIN 2/3 or CIN 3, ablative or surgical procedures are used to remove the precancerous lesions.
There is a significant unmet need for an immunotherapy for high grade cervical dysplasias that, unlike current surgical procedures, does not pose risk of causing pre-term births, and may also eliminate HPV throughout the body (not just at the surgical treatment site) and reduce the risk of new or recurrent precancers. Such a non-surgical treatment would provide an appealing alternative to caregivers and their patients.
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Titans Fall 5-1 to Jackals; Get Split in Elmira
November 18, 2012 - ECHL (ECHL) Trenton TitansTrenton (6-7-0-1, 13 points) entered the night with 27-straight penalty kills, but Elmira put an end to that quickly with a Louie Caporusso goal on the Jackals first opportunity at 2:09 of the first.
Trenton tried to fight back, but kept catching penalty after penalty, playing a man down five times in the frame. The last one carried over into the second and proved to be a back breaker.
Andrew Rowe struck 33 seconds into the period during a delayed penalty to make it 2-0. Then Kyle Bushee beat Niko Hovinen (2-4-0-1, 24 saves) at 2:06 on the new power play. Three power play goals in six tries gave the Titans a 3-0 hole they would not be able to climb out of.
Rob Bellamy and Rowe's second of the night gave the Jackals a 5-0 lead through two, before Andy Bohmbach finally ended the shutout attempt of goalie Maxime Clermont (2-3-1, 26 saves). Bohmbach scored his sixth of the year on the power play, using a wrister from the top of the right circle to beat Clermont with eight minutes left to play.
On the night Elmira - the number one power play at home (33%) and second best in the league overall (29.7%) - went 3-for-8 on the power play, while Trenton ended up 1-for-3 on the man advantage.
The two sides will meet again in Trenton, NJ, for a two-game set on Saturday December 1st (7:05 pm) and Sunday December 2ns (4:05 pm) at the Sun National Bank Center.
After The Horn
With their PPG, the Titans ended Elmira's perfect PK at home. The Jackals had 32 straight kills to start the season.
With an assist tonight, Stephen Schultz has a point in three straight games.
Bohmbach has four goals over his last three games.
Trenton is 0-7 when the opposition scores first, and have never led in any of those games.
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ECHL Stories from November 18, 2012
- Rajala nets two as the Thunder improve to 6-1-0 at Stockton Arena - Stockton Thunder
- Stockton Holds off Idaho, 4-3 - Idaho Steelheads
- Bulls Complete Improbable Comeback, Stun Grizzlies, 4-3, in Shootout - San Francisco Bulls
- San Francisco Ties at Buzzer, Beats Utah in Shootout - Utah Grizzlies
- Gladiators Hang on for 2-1 Win - Gwinnett Gladiators
- K-Wings Drop Second Straight To Solar Bears - Kalamazoo Wings
- Gladiators Slip Past Stingrays 2-1 - South Carolina Stingrays
- Game Preview: Stockton Thunder vs. Idaho Steelheads - Stockton Thunder
- ECHL Transactions - November 18 - ECHL
- Game Preview: Solar Bears vs. Kalamazoo Wings Today - November 18 - Orlando Solar Bears
- Bulls Look for Weekend Split at Home against Utah - San Francisco Bulls
- ECHL Announces Fine, Suspension - ECHL
- Stingrays Game Preview: Kids Day Today against Gladiators - South Carolina Stingrays
- ECHL Today - November 18 - ECHL
- Bulls Comeback Halted by Utah in 5-3 Loss - San Francisco Bulls
- Aces Complete Sweep of Eagles with 4-3 Win - Alaska Aces
- Condors Battle, But Fall in a Shootout 4-3 - Bakersfield Condors
- NHLers Help Aces Edge Eagles Again, 4-3 - Colorado Eagles
- Grizzlies Beat San Francisco 5-3 - Utah Grizzlies
- Titans Fall 5-1 to Jackals; Get Split in Elmira - Trenton Titans
The opinions expressed in this release are those of the organization issuing it, and do not necessarily reflect the thoughts or opinions of OurSports Central or its staff.


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Directions to the Visitors Center
Located in the southeast corner of campus, the University of Georgia Visitors Center is housed in the Four Towers Building. To obtain directions to the Visitors Center, please use one of the following options:
- Google Maps
- Visitors Center address: 405 College Station Road, Athens, GA
- Visitors Center GPS coordinates:
Local directions to the Visitors Center
(View video illustrations to find the Visitors Center once in Athens)
- Traveling south on US 129; south on US 441 and GA Hwy 15; south on US 29; south on GA Hwy 72; or west on US 78
- Traveling east on GA Hwy 316 and north on US 29; east on US 78; east on GA Hwy 138; north on US 441 and US 129; or north on GA Hwy 15
- Coming from downtown Athens
Parking at the Visitors Center
For access to the Visitors Center, visitors may park in the adjacent parking lot accessible directly from College Station Road. Visitors must obtain a parking permit from inside the center and display the permit in the dash of their vehicle. The parking lot connected to the Visitors Center lot via a traffic circle is UGA Lot E10. Parking in E10 is restricted to university staff permit holders. In the event that the center's parking lot is full, additional visitor parking is available in the pay-per-hour East Campus Parking Deck [map] [rates].
Directions to the Office of Undergraduate Admissions
The UGA Office of Undergraduate Admissions is located in Terrell Hall, which is sits in the heart of North Campus, approximately 1.7 miles from the Visitors Center. If you are signed up to attend an admissions information session prior to your tour, please visit the admissions office Web site for directions to Terrell Hall and the North Campus Parking Deck.
Please see below "Directions to the Honors Program" () for information on additional parking information in the event the North Campus Parking Deck is full.
Directions to the Honors Program
The UGA Honors Program is located in Moore College, which is also situated in the heart of North Campus, approximately 1.7 miles from the Visitors Center. If you are registered to attend an Honors information session prior to your tour, please click here for directions to the North Campus Parking Deck. Moore College is located to the west of the parking deck.
Please see immediately below () for information on additional parking information in the event the North Campus Parking Deck is full.
Additional Parking for Undergraduate Admissions and Honors
In the event that the North Campus Parking Deck is full and closed to visitors, visitors may explore parking options downtown [map] [rates], which is where the Graduate School is located and is adjacent to the North Campus area in which the Office of Undergraduate Admissions and the Honors Program are located.
Traveling by air
Hartsfield-Jackson Atlanta International Airport, Atlanta
Hartsfield-Jackson Atlanta International Airport is located 80 miles from the Visitors Center. Average travel time between the airport and the center is one-and-one-half hours, though travel time may be affected by Atlanta traffic. There is scheduled ground shuttle service between Hartsfield-Jackson and various points in Athens. For more information or to make a reservation, please contact Groome Transportation (706/612-1155). Rental car service is also available.
Directions from Hartsfield-Jackson Atlanta International Airport to the Visitors Center
- Upon leaving the airport, take Interstate 85 North.
- Follow I-85 to Georgia Highway 316 (Exit 106).
- Proceed east on GA 316 for approximately 40 miles until you see signs for Athens Perimeter (GA Loop 10). Important: Make sure not to exit at the exit for Bogart/Monroe at US Highway 78.
- Following the "University of Georgia/Lexington/Hartwell" sign at the junction of GA 316 and the Athens Perimeter (Loop 10), bear right onto the Athens Perimeter (Loop 10).
- Continuing on Athens Perimeter (Loop 10), proceed to and exit at College Station Road (Exit 7).
- Turn left onto College Station Road.
- After passing under the bridge, proceed through two traffic lights and the Visitors Center will be on your right in the Four Towers Building.
Athens-Ben Epps Airport, Athens
Athens-Ben Epps Airport offers flights to and from Atlanta and Nashville, TN via Georgia Skies. Local taxi service is available for transportation to and from Ben Epps Airport. Rental car service is also available.
Directions from Athens-Ben Epps Airport to the Visitors Center
- Upon leaving the airport, turn left onto Winterville Road.
- Continue on Winterville Road until it ends at Lexington Road (US Highway 78).
- Turn right onto Lexington Road (US 78) and proceed three additional traffic lights.
- At the third traffic light, turn left onto the Athens Perimeter (GA Loop 10).
- Continue on the Athens Perimeter (Loop 10) to Exit 7 and exit onto College Station Road.
- Turn right onto College Station Road.
- Proceed through the next traffic light and the Visitors Center will be on your right in the Four Towers Building.
Additional travel resource
Georgia 511 is a free phone service, hosted by the Georgia Department of Transportation, which provides real-time traffic and travel information 24 hours a day, seven days a week. The service provides information for all state routes and interstates and gives estimated travel times in metro Atlanta. Callers can speak to live operators to report incidents or request assistance, or connect to other services such as transit partners, airports, tourism information and 511 systems in neighboring states.


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POSTED: 11:32 a.m. HST, Jul 13, 2011
A Maui accountant who led a long-running Ponzi scheme that cost his investors $8 million is being sentenced to serve nearly 12 years imprisonment without the possibility of parole.
U.S. District Judge David Ezra handed down the sentence Wednesday against 61-year-old Lloyd Y. Kimura, who previously pleaded guilty.
Kimura, the brother of Hawaii County Prosecuting Attorney Jay Kimura, told the judge he's sorry for his crimes.
Kimura used his business, Maui Industrial Loan and Finance Co., to attract investments since 1986, with money collected by later customers used to pay initial clients.
Kimura was ordered to repay his 50 victims the $8 million they lost.
His assets amount to only a fraction of the amount he owes, so his income will be garnished after he's released from prison.