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Editors' Review
+The only thing cooler than free media players might be the free codecs that improve playback quality or enable more file types. There are so many to choose from that it's often hard to know which is best, especially when there's more than one or two choices, like for MP3s: LAME, FLAC, AC3, and so on. JockerSoft's CodecInstaller is a free tool that scans your system, identifies your media players, and suggests codecs for them that can expand or improve their capabilities.
CodecInstaller's compact, vertically oriented interface has three main controls, each self-explanatory: Installed Codecs, Analyze File, and Install Codecs. A Configuration button let us change the interface language and schedule updates. We pressed Installed Codecs, and instantly CodecInstaller produced a tabbed dialog displaying our system's Video, Audio, Other, and General codecs -- lots of them. We could click Update to refresh the list or Settings to set Minimum merit and allow the program to show filters not detected by DirectShow. Selecting any codec and right-clicking it produced a menu accessing the codec's Details and Priorities and Mappings (requires Microsoft Visual C++ 2005) and letting us Remove the codec or copy it to the clipboard. We clicked Analyze File and browsed to the folder containing one of our video codecs. The program displayed a list of possible formats, but which one would work? CodecInstaller provides the answer with a Render button that tests whether DirectShow can render the file. Whether CodecInstaller finds any missing or updated codecs for your software, you can install a variety of codecs using the program's Install Codecs tool, which displays a list of common codecs like AAC, Ogg Vorbis, DivX, and even Windows Media.
One of the hardest jobs in codec maintenance is finding the darn things in your system. CodecInstaller takes care of that by finding them all and displaying not only their location but also version, company, and more. Copying a codec's location, searching for it, and browsing to its folder in CodecInstaller helped us quickly analyze and update our most-used codecs. It'll be ready when you need a new codec to play a file, too.
Publisher's Description
CodecInstaller is a Windows program that detects the Audio and Video codecs installed on your system, analyzes files to understand which codecs they require and suggests you to install them. CodecInstaller can also be used to distribute video files on a CD, to be sure that who receives the CD will have all the necessary codecs installed with a single tool he will be able to check if the codecs are already installed and up-to-date.


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Search Result
Search Tags: Connecticut
Online Chat: Ideas to Save the Failing Budget Process
Former U.S. Comptroller General David Walker and Connecticut State Representative Diana Urban join Federal News Radio for a free online chat to discuss what needs to be done to fix the failing federal budget process. View an archive of the recent chat.
Tags: David Walker , Diana Urban , online chat , budget , Ideas to Save the Failing Budget Process , Tom Temin
What the federal government can learn from the state of Connecticut
The state of Connecticut relies on a results-based accountability model to develop its budget. Rep. Diana Urban says the system offers a structure that allows lawmakers to create a shared vision and get rid of programs that are not achieving that vision. Rep. Urban's column is part of Federal News Radio's special report, Now or Never: Ideas to Save the Failing Budget Process.
Tags: Diana Urban , budget , results-based accountability , Ideas to Save the Failing Budget Process

subset: commoncrawl


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Chinese New Year: The Snake - Brooklyn Children's Museum
Hours: 2:30pm Ages: YE Price: $9 Address: 145 Brooklyn Ave. - 718-735-4400 Crown Heights, NY 11213 www.brooklynkids.org Description: Kids learn about the Chinese zodiac and the year of the Snake. Make a craft and discover what this year may bring. |


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Lovely Set
By Poopsy
from Montreal
Lovely set, great for when you want a more delicate neck piece. I use it with blouses, V-necks, anywhere you need just a little something. Great value.
By Heather
from abbotsford b.c.
I bought these for gifts, along with the matching stud earrings, will make a nice sets.
Great Set!
By Bee
from Hamilton
I bought this set of Himalayan Gems pendants some time ago and they are my go-to pieces. They are just great with anything I wear. The quality is excellent, the silver is substantial and the stones are a lovely colour and cut, the price is amazing. I would recommend these to anyone, they are charming.
match the earrings
By Happy feet
from POWELL RIVER
i like having matching jewelry


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True the Vote sues for inspection of West-Murphy election records
True the Vote, a group dedicated to protecting ballot integrity and ensuring fair election contests, has filed suit against the St. Lucie County Supervisor of Elections in Florida. The suit demands the release of "all records pertaining to the recent 18th Congressional District election and subsequent recounts between Rep. Allen West and Patrick Murphy be reviewed in order to perform a comprehensive third-party audit."
True the Vote president Catherine Engelbrecht released a video statement announcing the lawsuit and laying out her group's criticism of St. Lucie elections officials:
Engelbrecht stressed that she doesn't expect to overturn the results of the election, which Murphy narrowly won after the tortured recount process she describes. She wants full details of the procedure made public for the benefit of future elections. "This dramatic recount was an extraordinary example of how our elections can suffer systematic failure," Engelbrecht said. "We run the risk seeing episodes like this becoming ordinary if citizens do not demand answers and hold election officials accountable. The American people own the voting system – we have the right to ask tough questions when we witness the failure of one of America's core functions."
She noted that the "clock is ticking" for a comprehensive audit of the election, because "each passing day heightens the risk of critical documents being disposed of."
True the Vote's press release includes a chronology of the election and its aftermath, highlighting the irregularities they wish to investigate:
On November 6, St. Lucie County election administrators admitted that ballot tabulation machines suffered a malfunction, preventing early vote totals from being properly counted. County workers were forced to hand-feed ballots into tabulation machines as a result.
On November 8, West demanded a full recount of early votes and copies of poll sign-in records to compare voter participation against ballots cast. West's requests were denied and ignored, respectively.
On November 9, West demanded that a Florida state court impound all ballots and voting machines, but made no claims of the sort True the Vote makes today in federal court. West's requests in state court were denied.
On November 10, St. Lucie County "unofficially certified" the vote count for CD-18 and publicly acknowledged "uncertainty" over the early vote totals. St. Lucie County called an emergency meeting to "recount all ballots cast during early voting." The county later reversed itself, only performing a partial retabulation. After the partial retabulation, the lead for Patrick Murphy decreased.
On November 13, Defendant Gertrude Walker held a press conference admitting that her staff acted with "haste" and that "mistakes were made" throughout the tabulation and partial recount process. Florida Division of Elections auditors were dispatched to investigate how 799 votes disappeared or changed hands during the partial recount.
On November 16, Defendant Walker claimed to find 306 early votes in a box at her office that had not been counted. The St. Lucie County Canvassing Board ordered a recount of all early votes, with a deadline set for noon on November 18. On November 17, the full recount operation was relocated to a privately-owned property. County workers were evicted from the premises late at night, suspending the recount until the next morning.
On November 18, County workers failed to meet the deadline, instead certifying the original November 10 tabulation, which officials claimed "uncertainty" over the accuracy of the results. True the Vote later demanded to review poll books, "voter credit" lists, felon files and others to perform a comprehensive audit of the CD-18 tabulations. Inspection rights were not granted and so this lawsuit was made necessary.
One reason the West-Murphy race seemed odd to outside observers was the rather high volume of ticket-splitting by Republicans in West's district. This led to some early accusations of ballot-box shenanigans by dejected West supporters, although it has nothing to do with the specific issues True the Vote wishes to investigate, or the legal case they have brought. Bloomberg Businessweek took a look at the ticket-splitters shortly after the election, and concluded it might have been fallout from early unpleasantness between West and his Republican primary opponent, Sheriff Bob Crowder, as well as the shifting fortunes of the Tea Party movement that held West as one of its paladins:
Murphy won by 1,900 votes. In Martin County, the district's Republican stronghold, West received 4,800 fewer votes than Mitt Romney, while Murphy outperformed Obama by 3,700 votes, a sign that a significant number of Republicans split their ticket. It didn't help that in the final weeks of the race, Crowder, West's spurned GOP rival, endorsed Murphy. West believes he lost because voters accustomed to pandering politicians couldn't handle his directness. "I just talked the truth. I think that a lot of people maybe are not comfortable hearing the truth."
Another possibility is that his rapid rise and fall coincided with the public's equally brief enthusiasm for the mad-as-hell ethos of the Tea Party. When West was elected two years ago, 40 percent of voters nationwide said they supported the movement, according to exit polls. This year, support was down to 21 percent. West was one of several members of the Tea Party caucus who lost reelection to the House. "Anger only gets you halfway there," says Gene Ulm, West's pollster. "You have to have an agenda. And if the Tea Party is going to make the transition and be impactful, focusing that agenda is what needs to be done."
West recently announced plans to host an Internet video program for PJ Media, called Next Generation Today. Set to launch in February, it will focus on bringing the news to young Americans, for whom securing economic liberty and restoring fiscally sane, limited government is particularly important:


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Programme event
Project event
Newsnewsback to listprintProject Cycle Management Training for potential Applicants under Third Call - Registration is open!
Procurement Announcement
Please, click here to download the document (in original version - UA language). read more » "A new star shines over the village of Velykyy Bychkiv"Official opening of the newly established Kindergarten No5 "Zirocha" was held in V. Bychkiv village, Rakhivskyi district in Zakarpatska oblast of Ukraine in the frame of... read more » Procurement notice on "Construction of non-residential buildings"Procurement notice on "Construction of non-residential buildings (new construction, reconstruction, major and minor repairs)," DKPP code 41.00.4, reconstruction... read more » Public Procurement Notice on Services on construction projects managementPublic Procurement Notice on Services on construction projects management (technical supervision during the reconstruction works of existing units and... read more » |


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Comments from GregM70
Showing 2 comments
commented about
Bronxville Cinemas
Mar 26, 2010 at 1:29 pm
This was a really nice theater in the late 1960's mid 1970's when it had 1 screen. I remember seeing "Smokey and the Bandit" there (1977) soon after that it was made into a tri-plex which completely ruined the theather. The upstairs (which used to be the balcony)was a joke.
Parents could drop the kids off for the matinee – Bronxville was very safe back then
commented about
Central Theatre
Mar 26, 2010 at 1:01 pm
I believe I saw a film at this theater in the mid 1960's. I remember the cartoon. It would have been about 1966-1967 I was 3 or 4 years old. It was probably turned in the bowling alley after that. Anyone know the date it was closed as a theater?


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Got a tip for us? Let us know
Jan 2, 2013, 12:59 PM | #1 |
MacBook Pro BootCamp Help!
Help something has happened im trying to set up bootcamp on my mac i was strolling through when it got to the windows part i couldnt find which disk to use to install it and it said to try and reformat something so and it did that and after that finish i got stuck so i shut off my computer and now when it powers up my computer is stuck at a black screen with a white blinking underscore
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Jan 2, 2013, 01:02 PM | #2 |
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Jan 2, 2013, 01:04 PM | #3 | |
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Jan 2, 2013, 01:07 PM | #4 | |
If you mean the "disk utility thing" linked to in the second link, that guide has the following to say:
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Jan 2, 2013, 01:13 PM | #5 |
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Jan 2, 2013, 01:20 PM | #6 | |
Force Eject a Stuck CD or DVDWhat exact MacBook Pro (size and year of release) and Mac OS X version do you use? |
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Jan 2, 2013, 01:23 PM | #7 | |
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Jan 2, 2013, 01:34 PM | #8 | |
Okay, since the links do not seem to work, we can do it this way: Shut down your Mac by holding down the power button. Start the computer by pressing the power button. Immediately press the OPTION/Alt key. Select which OS to boot from via the arrow keys. Press Enter. If you chose Mac OS X to boot into, it should be fine then. If not, shut down the Mac again and press the power button to start it again. Immediately press CMD+R to boot into recovery mode and select Disk Utility from the Utilities menu. For further information about recovery mode and such, you can look at the links I provided, or the quote in post #4. |
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Jan 5, 2013, 03:16 PM | #9 |
@macsupport Hi *this evening I tried to install windows 7 using boot camp for my MacBook pro. I was going though the options. I created the partition and ran the windows disk and began the windows setup. When it came to select where I wanted to place the Bootcamp file I went to click on continue but it said the file was the wrong format. So thinking that I broke my MacBook I shut it down. Now when I start it up with a message insert *disk or any key. How do I get back onto mac os?*
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Jan 5, 2013, 03:30 PM | #10 | |
Then in Mac OS X delete the partition you wanted to install Windows onto via Disk Utility and expand the Mac OS X partition again. Then start Boot Camp Assistant to create a partition for Windows with the size of your choice and follow the steps shown to you. To learn more about Mac OS X: Helpful Information for Any Mac User by GGJstudiosPS: We are not an official Apple or Mac support forum. "How to maximise your MacRumors troubleshooting experience" created by mad jew in 2006 |
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James P. Gray, a Newport Beach resident, is on the Libertarian Party's ticket as the nominee for vice president. He regularly writes the Daily Pilot column It's A Gray Area, which will be suspended while he campaigns through November. Gray is a retired judge with the Orange County Superior Court. (SCOTT SMELTZER, Daily Pilot / July 6, 2010) |
Retired Orange County Superior Court Judge James P. Gray, who writes a regular column for the Daily Pilot, has received the Libertarian Party's nomination for vice president.
The Newport Beach resident earned the nomination at the party's weekend convention in Las Vegas. Gary Johnson, the former Republican governor of New Mexico, is party's the pick for president.
Gray announced the news to friends in a letter, which the Pilot published Friday. His Sunday Forum column, It's A Gray Area, will be suspended while he campaigns through November.
"Honestly, I would not do this with anyone except Johnson," Gray wrote. "But after consulting with my wife and other friends and advisors, I have agreed to do so. But I set one condition upon my entering the race: that we would run to win. He absolutely agreed."
Gray is perhaps best known in Orange County for his support of legalizing marijuana and ending the war on drugs, which he views as too costly, violent and unproductive.
His other views, as stated in his recent letter, are generally in accordance with the Libertarian Party's small government platform: reducing government regulation, eliminating deficit spending, using U.S. troops only to protect the national interest, overhauling the tax code, and allowing competition in the school and health-care systems.
Johnson, according to media reports, holds small government views similar to presidential candidate Ron Paul. Johnson supports same-sex marriage and getting the U.S. out of Afghanistan, according to The New York Times.
Before running as a Libertarian, Johnson ran for the 2012 GOP presidential nomination but dropped out just before the Iowa caucuses, according to The Times.
Twitter: @TheDailyPilot


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Wallpapers / AJ
Artist's Note
darkened the whole thing, replaced the text with my logo and put a sweet lil circle. :) Comments (11)
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My PaletteAdd colors with the "color picker" tool () or from the image's palette (). To save your palette, you must sign up.Also by this artist (more)Also in Wallpapers (more) |


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Aug 14, 2013 6:53 PM
14u Team looking for 2(open practice Sunday)
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The Cunningham Crushers are looking for 2 players. We are looking for an experienced catcher and a speedy utility player for our fall and summer 2014 team. We plan on playing a very aggresive schedule with the focus being on ASA tourneys. We are coming off a very strong summer with a top 3 finish at the Seaa World Series.If you have what the dedication and want to play hard call or text coach Chuck @615-417-3480 or by email @ firstname.lastname@example.com We are having an open workout This Sunday @ Legions field from 2-5
Online Golf Tee Times with Last Minute Tee Time Deals & Discounts
Cool Running is the complete online resource for runners.
Find your favorite campground from the best campgrounds listing!


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The Chennai Corporation has for the third time invited bids for the construction and operation of a multi-level parking facility for cars and two wheelers at the Broadway bus station.
The project, which has been in the offing for at least two years now, will be further delayed: the process of floating tenders and evaluating bidders will take months.
According to Corporation officials, work to establish the multi-level parking facility would take two years. The facility was proposed in one of the most congested areas of north Chennai. The first tender did not receive any bids. The pre-bid meeting for fresh tenders floated recently was attended by eight companies. They asked for more time to submit tender documents. The next process, which progressed to the financial evaluation stage in May this year, was cancelled after a Kolkata-based firm that had made it to the evaluation stage failed to meet the requirements.
According to officials, the firm asked the civic body for Rs.1 crore to operate it, whereas as per tender stipulations the firm had to pay the amount as royalty to the civic body.


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Casefile Clues
Michael John Neill's weekly genealogy how-to column.
Tuesday, November 29, 2011
The Most Likely Error
Out of all the pieces of information on a person in, say the 1860 US census, what piece do you think is the most likely to be incorrect--why?
(this was copied from our Facebook wall)
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Osborne 1, Planet 0 – but it is not Game Over yet
Following on from previous items I have posted regarding the potentially-illegal Energy Bill drafted by the Conservative Party, such as:
- A very unsustainable Energy Bill (24 May 2012)
- Is the UK government on a flight from reality? (19 September 2012)
- Greenest government ever – Fail (8 October 2012)
- A plea from the Executive Director of Greenpeace UK (16 November 2012)
… this is the latest email I have received from Greenpeace:
Hi Martin,
A black smog is hanging over Parliament.
Following the 'Energygate' scandal, the reputation of the Conservative Party on climate change lies in tatters on the steps of Westminster. The hardline anti-renewable energy faction in the Conservatives has cowed the Lib Dems into submission.
The draft Energy Bill leaked last Friday was a major blow to progress on tackling climate change. The Bill is a key opportunity to drastically cut our carbon emissions.
These politicians have raised the stakes, now it's time we do the same.
Find a local Greenpeace group near you to take your campaigning to the next level.
If the Energy Bill passes unchanged, it will pave the way for more fossil fuels, unstable household bills and increasing fuel poverty.
It will fire the starting gun for George Osborne's dash for gas. But there's a long way to go before the finish line. It has to make it over a number of hurdles before it is enshrined in law so it's not over yet.
Together we've changed the political landscape on energy, helping to make this climate change scandal front page news. We are a movement of over 40,000 – and growing – people telling David Cameron to get his priorities straight.
As the global climate negotiations offer little hope, our responsibility in the UK to cut carbon emissions has never been more important. Securing a strong Energy Bill could see virtually carbon-free electricity by 2030.
We know the Arctic is melting faster than ever before – this year was the lowest ice on record. If that's not an urgent call for us to up our game, I don't know what is.
Our local groups are the beating heart of Greenpeace. Find one near you and join us.
See you soon,
Pete & the energy team
Greenpeace UK
The UK government should not be allowed to ignore the fundamental purpose of the Climate Change Act 2008 or the agreement reached at the G20 Summit in Pittsburgh PA in 2009. It cannot be right to burden consumers with the cost of investing in renewable energy and simultaneously guaranteeing a subsidised future for fossil fuel combustion. I therefore hope all readers in the UK will take action to stop this Bill being passed into Law.
15 Responses
Action- but the best course is what?
Read Delingpole's 'out-there' blogs and the hordes of delingbots have a similar message, and just like their hero it is becoming more rabid in hundreds [thousands] of comments. They represent the Tea-party wing of British politics: UKIP. Just like their American counter-parts, the damage they cause out weighs their performance. I did a little research and actually counted how many delingbots contributed to an average 2000 comment post. More than half were created by 17 individuals with one producing 10% of comments.
Political parties fear their extremities and the Conservatives have a strange relationship with UKIP. Just like the Republicans the more they pander to their right the less likely they will ever gain substantial majorities but they also have an irrational fear of losing them. Osborne may of course, be pandering to them for an ascension in the future.
I can take the Conservative party seriously- on occasion- and not actually agree with them- although there were a couple of moments in Cameron's conference speech I applauded, when he tackled offshore wind and foreign aid. The rabid right, however, is denial of rationality, I'm not big on federalism but they put me off and make me a Europhile, their arguments on fuel, Europe, climate change and immigration are more wishful thinking than policies.
The real hope is bi-partisan agreement which evidently existed when the Carbon Act was passed. We need our politicians to lead, to set the agenda and to see a short term energy fix with gas will cost more. We need them united on this one issue.
I really hope others like Obama or British business have the balls and start setting the agenda so the UK conservative can see UKIP as nothing more than a pointless distraction.
Thanks Jules. As you may have noticed, I do not waste my time on Delingpole (or his equally foolish followers) anymore. You are right to say they are a UK equivalent of the US Tea Party movement and, sadly, like a mold infesting decaying fruit, they seem to be inside every arm of the British political establishment – even the Labour Party is not immune:
https://lackofenvironment.wordpress.com/2011/10/18/graham-stringer-mp-is-no-watermelon/As for the synchronicity between Euro-scepticism (with which I have sympathy) and climate change scepticism (with which I clearly do not), as you know, I spotted this too myself a year or two ago:
https://lackofenvironment.wordpress.com/2011/10/20/why-are-euro-sceptics-also-climate-sceptics/If the threat of UKIP makes David Cameron take a more Euro-sceptic stand that will be no bad thing IMHO. Boy, are we lucky Tony Blair never succeeded in getting the UK to agree to get join in EMU. It was – and is – a colossal 'Tower of Babel' project that has now failed.
I'm not a federalist – far too clunky – but the EU could be the lead in climate change policy. If everyone is committed then it becomes a powerful block to influence the US and the Brics; and also it means no-one gets to have a free ride.
In the Guardian poll – would you pay more for green electricity? the majority voted "no". Likewise, back in the 60s, the death penalty was widely accepted; and it took visionaries to simply impose what was best (i.e. abolition). Don't ask me – just impose it- because even I would vote for a free lunch [given a choice].
I do not object to paying more for green energy (I chose to do so while I was employed). As I have said, I object to being asked to pay more for my electricity to help the government invest in renewable energy, whilst the government helps to subsidise the continuance of business as usual for the fossil fuel lobby. Our politicians appear to be ignoring the majority of the adult population of this country who accept the need to decarbonise our electricity generation systems and are, instead, being misled by the fossil fuel lobby into propping-up an increasingly ineficient and expensive relic of the Industrial Revolution… This is not what I would call 'democracy in action' and, I seem to recall that such actions had very unfortunate consequences for those in power in Russia 95 years ago! This is not a call for a Communist revolution; but it is a warning from history! Furthermore, I think what we need is a Grassroots revolution; which is as far away from an centrally-planned economy as it is possible to get.
Euroscepticism is yet another example of total foolishness, a distraction from the main event. Yes, it's true to say that "EMU is a project that has now failed" — but the message we should be taking home is that our entire economic system is a 'project' that is on the verge of a(nother) catastrophic failure. Constantly pointing the finger at the folly of others makes us feel good about how clever we are, but in reality the finger's pointing in the wrong direction.
(With thanks to Christine for the link to that brilliant video.)
We're all in this together. And if we never acknowledge that, we'll never sort the problem.
Thanks Pendantry. When we point at others (as CBDR within the UNFCCC invites all parties to do), we actually have three fingers pointing back at ourselves. (But I am still glad the UK is not in the EMU.)
Good point, well made! And three fingers, well, that's a combination of both UK and US variants on a theme… ;)
PS Me, too — almost lead with that but didn't want the distraction :D -
Thanks Pendantry. I am glad we can agree on EMU.
For the benefit of others not familiar with the acronym, CBDR = Common but differentiated responsibilities (Principle 7 of the 1992 Rio declaration).
Sorry — couldn't resist :D
Absolute classic piece of British TV history. If this were a word association test, your psychiatrist would no doubt be very impressed. :-)
Thanks for taking a stab at interpreting some of my more esoteric commenters (who I fear may be time-wasters).
'Time-wasters'? Maybe, but that's not the impression I got. One seemed to be suffering from VD (verbal diarrhoea, not the other kind) and the other simply had a blatantly-present agenda, which in my book are not nearly as bad as the hidden type because the latter variety are far more obfuscatory and thus, intentionally or otherwise, serve inactivsm (which should not be confused with intactivism). But I should talk — or, rather, shouldn't — as my wibblings could be interpreted as serving that same beast. All I can do is assure you that such is never my intent.
Glad we cleared that up! :)
It may be that I am in a very uncharitable mood but one of them flip flops about more than Mitt Romney (and never answers my questions); and the other was probably Spam.
Peter Lilley stars on Climate Progress. Conflict of interest WRT The Energy and Climate Change Committee – very much so.
Will the new Governor of the Bank of England see pressure brought, or opposition swept aside, for import of tar sands oil from Canada and also that GWPF Hintz connection doing the same for Australian coal.
Perhaps well crafted letters of information on the dangers posed by the policies of these enemies of future generations should be sent to their kith and kin.
Canada is the very last country on Earth that we should seek to emulate. God help us if the new governor of the Bank of England thinks his current government is a good example to follow.
[…] 2012/11/27: LoE: Osborne 1, Planet 0 — but it is not Game Over yet […]


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At the end of WWII three men with three very different lives come home. Fredric March was a platoon Sargent in the South Pacific who's a banker with a loving wife (Myrna Loy) and two teenage children including Teresa Wright. Harold Russell (a real life Army veteran who lost both his hands in 1944) was a seaman who lost his hands in an explosion. He lives with his parents and has a fiancee. Dana Andrews is an Air Force captain and bombardier married to nightclub waitress (Virginia Mayo) who's been living the party life while he's been gone. Their lives might be different, but all three face the same problems with readjusting to civilian life and putting the demons of war behind them. That's all you really need to know about the story.
THE BEST YEARS OF OUR LIVES rightfully won a wheelbarrow full of Oscars, but I think it should have won two more. Most notably Teresa Wright for Best Supporting Actress. I thought she was absolutely stunning in her performance of a young woman tormented with her emotions. I haven't yet seen Anne Baxter's performance in THE RAZOR'S EDGE (she did win) but I can't imagine that it tops Teresa's performance. [I put TRE at the top pf my Netflix queue so I should have a review up in the next few weeks] Also it should have won for Best Cinematography.
Another thing is Fredric March as Best Actor. I do agree that he was quite good, but the Oscar should have gone to Jimmy Stewart in IT'S A WONDERFUL LIFE. And here's one that'll probably anger some people but Dana Andrews should have won over Harold Russell for Best Supporting Actor. Russell was good and he did get an honorary Oscar for his brave performance, but as far as acting skill goes Dana Andrews turns in one of the best performances of his career in THE BEST YEARS OF OUR LIVES. And with as many outstanding performances as he had that saying something.
I have a lot to say about TBYOOL's, but honestly your time would be better spent just watching the movie, so get to it!


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Neuroinflammation evolves as a multi-facetted response to focal cerebral ischemia. It involves activation of resident glia cell populations, recruitment of blood-derived leucocytes as well as humoral responses. Among these processes, phagocyte accumulation has been suggested to be a surrogate marker of neuroinflammation. We previously assessed phagocyte accumulation in human stroke by MRI. We hypothesize that phagocyte accumulation in the macrosphere model may resemble the temporal and spatial patterns observed in human stroke.
In a rat model of permanent focal ischemia by embolisation of TiO2-spheres we assessed key features of post-ischemic neuroinflammation by the means of histology, immunocytochemistry of glial activation and influx of hematogeneous cells, and quantitative PCR of TNF-α, IL-1, IL-18, and iNOS mRNA.
In the boundary zone of the infarct, a transition of ramified microglia into ameboid phagocytic microglia was accompanied by an up-regulation of MHC class II on the cells after 3 days. By day 7, a hypercellular infiltrate consisting of activated microglia and phagocytic cells formed a thick rim around the ischemic infarct core. Interestingly, in the ischemic core microglia could only be observed at day 7. TNF-α was induced rapidly within hours, IL-1β and iNOS peaked within days, and IL-18 later at around 1 week after ischemia.
The macrosphere model closely resembles the characteristical dynamics of postischemic inflammation previously observed in human stroke. We therefore suggest that the macrosphere model is highly appropriate for studying the pathophysiology of stroke in a translational approach from rodent to human.
Inflammation plays an important role in the cascade of events following cerebral ischemia that may impact on the extent of tissue damage, infarct demarcation, tissue repair und functional recovery, and may hence act as a key target for therapeutic intervention [1,2].
Animal research has characterized postischemic inflammation as a multi-facetted response involving activation of resident glia cells and recruitment of blood-derived leucocytes as well as cascades of humoral responses [2-4]. In the classical transient middle cerebral artery occlusion (tMCAO) model, hematogeneous cells including polymorphonuclear neutrophils (PMN) and macrophages rapidly infiltrate the ischemic region [5-7].
Translating rodent research into the situation of human stroke, substantial progress has been made in visualizing aspects of postischemic inflammation in man. Starting with the first in vivo visualization of peripheral benzodiazepine receptor-expressing inflammatory cells using Positron Emission Tomography (PET) and the radiotracer [11C]PK11195 [8], postischemic inflammation has been repeatedly characterized by PET [8-11], magnetic resonance imaging (MRI) [12], and cell specific contrast agents detected by MRI [13-15]. Early histopathological descriptions suggest a significant impact of permanent versus transient ischemia on the dynamics of inflammation [6]. Additionally, in the classical tMCAO model, tissue damage and glia activation evolve in complex spatial and temporal dynamics that make it difficult to interpret the results and to translate them into the human situation [16,17]. Different dynamics of MRI signatures in the tMCAO model and human stroke further complicate a translational approach [15]. Accordingly, we searched for an experimental stroke model with particular regard to the dynamics of postischemic inflammation that resembles the human situation.
In the rat macrosphere model, permanent focal ischemia is induced by intra-arterial embolization of a defined number of TiO2 spheres into the middle cerebral artery (MCA). With respect to parameters such as infarct development over time, final lesion size and clinical outcome, this model is comparable to the established pMCAO (permanent MCAO) model using an intraluminal thread [18,19]. However, in contrast to the permanent suture model, hypothalamic injury followed by pathological hyperthermia is avoided in the macrosphere model [20,21]. Moreover, macrosphere injection mimics arterio-arterial embolism of arteriosclerotic plaque material as the leading etiology of human stroke, while the thread occlusion model rather simulates a thromboembolic event with subsequent thrombolysis and large-vessel reperfusion [22]. Importantly, neuroinflammation has not been described in an arterio-arterial embolic stroke model to date.
Hence, we investigated key features and dynamics of postischemic inflammation in the macrosphere model and compared our findings to the human situation as revealed by previous PET and MRI Studies.
Animals and Surgery
All animal procedures were in accordance with the German Laws for Animal Protection and were approved by the local animal care committee and local governmental authorities. Male Wistar rats (n = 33) weighing 270-340 g were anesthetized with 5% isoflurane and maintained with 2.5% isoflurane in 65%/35% nitrous oxide/oxygen. Throughout the surgical procedure body temperature was maintained at 37.0°C with a thermostatically controlled heating pad. Ischemia was produced by intra-arterial injection of 4 TiO2 spheres into MCA as described elsewhere [19]. Briefly, after exposure of the left common carotid artery (CCA), internal carotid artery (ICA) and external carotid artery (ECA), the ECA and the pterygopalatine branch of the ICA were ligated. PE-50 tubing was filled with saline and four TiO2 macrospheres (Ø 0.315-0.355 mm; BRACE, Alzenau, Germany). The macrospheres were advanced via ICA into the MCA by a slow injection of approximately 0.2 ml saline (Figure 1A). In sham-operated animals, the same operation procedure was used without injection of macrospheres (n = 4). Following operation, the animals were transferred to their cages after they had fully recovered from anaesthesia. During the experiment all animals received an intensified care with subcutaneous saline injections (5 ml 0.9%NaCl/day) and moistening of food pellets. Animals in apparent clinical distress were sacrificed, excluded from the study and replaced.
Figure 1. Characterization of the macrosphere stroke model. (A) Basal view of the rat brain displaying the cerebral arteries following macrosphere-injection into the MCA. One macrosphere is located in the origin of the MCA and the distal ICA (arrow). Bar: 5000 μm. (B) Schematic drawing of the rat brain (dorsal view) to localize tissue samples collected from the ischemic lesion [A] and contralateral cortex [B]. (C) Representative H&E staining of coronal brain sections demonstrating the extent of the ischemic lesion 7 days after ischemia induction. Objective 1×; bar: 5000 μm.
Histology and Immunocytochemistry
Groups of n = 3 animals each were allowed to survive for 24 hours, 3 days, and 7 days after MCA embolisation with TiO2 spheres before they were decapitated under deep anaesthesia with isoflurane. The brains were rapidly removed, frozen in 2-methylbutane, and stored at -80°C prior to further histological and immunocytochemical processing. Adjacent serial coronal brain sections were cut at 500 μm intervals (slice thickness 10 μm) and stained with hematoxylin and eosin (H&E) according to standard protocols. Anti-NeuN (clone A60, dilution 1:1000, Millipore, Billerica, USA, cat-# MAB377) was performed to recognize the DNA-binding between neuron and the specific protein NeuN, which is presented in most CNS/PNS neuronal cell types. For the identification of astrocytes, we used mAb against Glial Fibrillary Acidic Protein (GFAP) (clone GFAP, dilution 1:1000, Millipore, Billerica, USA, cat-# MAB360) and Vimentin (VIM) (dilution 1:2000, Millipore, Billerica, USA, cat-# MAB3400). The mAb against the complement receptor 3/CD11b identified microglia/macrophages (clone OX42, dilution 1:1000, AbD Serotec, Oxford, UK, cat-# MCA275R). Microglia activation was assessed by staining for MHC class II (clone Ox6, dilution 1:400, AbD Serotec, Oxford, UK, cat-#MCA46G). Phagocytic cells were identified with mAb ED1 (clone ED1, dilution 1:1000, AbD Serotec, Oxford, UK, cat-# MCA341). A double staining with anti-Iba1 (dilution 1:1000, Wako, Neuss, Germany, cat-# 019-19741) and anti-NeuN was performed additionally. Iba1 is up-regulated upon activation of microglia allowing the discrimination between resting and activated microglia. For visualization, the ABC Elite kit (Vector Laboratories, Burlingame, CA, USA) with diaminobenzidine (Sigma, Munich, Germany) or Vector SG substrate kit for peroxidase (Vector laboratories, Burlingame, CA, USA.) for anti-NeuN staining as the final reaction product was used.
To quantify phagocytic cells at day 7, the area of ED1-positive cells was measured by the analysis software Image J (1.40G, National Institutes of Health, USA) and related to the ipsilateral hemisphere.
Quantitative real-time polymerase chain reaction (PCR)
For PCR analysis, another group of animals were sacrificed 4 hours (n = 5), 24 hours (n = 5), 3 days (n = 5), and 7 days (n = 5) after ischemia induction. In addition, 4 sham-operated animals without infarct served as controls. For RNA isolation, a sample of the cortex within the infarct core (sample A) and contralateral hemisphere (sample B) were prepared along with non-ischemic cortex from control brains (Figure 1B). Approximately 30 to 50 mg tissue per tissue sample (wet weight) were obtained. Total RNA was prepared using the Trizol reagent (Gibco BRL, Gaithersburg, MD) and quantified spectrophotometrically. One microgramm RNA was reversely transcribed using oligo (dT)19 (G/A/C) primers and Superscript II reverse transcriptase (Gibco-BRL, Gaithersburg, MD) according to manufacturer's protocol. Quantitative assessment of TNF-α, IL-1β, IL-18 and iNOS gene expression levels was performed using a 7900HT Fast Real-Time PCR System (Applied Biosystems, Weiterstadt, Germany) and the Sybr Green Universal Master Mix (Applied Biosystems) and gene-specific primer pairs as described previously [23,24]. In all PCR analyses, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) [24] was used as the reference gene since it exhibited constant expression levels under all tested conditions. Relative gene expression levels were determined according to the manufacturer's ΔΔCt method. For quantification of PCR data, mRNA levels of the ipsilateral hemisphere were compared to levels of the contralateral hemisphere as well as to values of control animals.
Statistical analysis
The statistical analysis was performed with SigmaPlot 11 (Systat Software Inc, California, USA). Data are presented as mean ± SD. For the analysis of PCR results, two-way analysis of variance (ANOVA) with a post hoc test of Holm-Sidak was used. Statistical significance was set at the less than 5% level (p < 0.05).
Characterization of the macrosphere model
Four TiO2 spheres were injected into the ICA after ligation of the pterygopalatine artery, leading to a permanent occlusion within the ICA/MCA vessel arborisation. In all animals, one or more macrospheres directly blocked the proximal MCA (Figure 1A). H&E staining verified the infarct localization in the MCA territory of all animals (Figure 1C).
All animals showed circling behavior 24 hours after infarct induction but recovered incompletely till 72 hours. Animals in clinical distress were sacrificed, excluded from the study and replaced (n = 4).
Infarct demarcation
One day after induction of stroke, the infarction is already well demarcated from vital tissue (Figure 2A, D, G). H&E staining showed eosinophilic coagulation necrosis in the ischemic territory (Figure 2A) and loss of GFAP staining indicated cell loss and edema within the infarct core (Figure 2D). The infarct border is even more clear-cut 3 days after macrosphere injection (Figure 2B, E, H) and the surrounding tissue appears to be slightly hypercellular. Around day 7, a sharp infarct demarcation with a surrounding hypercellular infiltrate containing reactive astrocytes (revealed by GFAP) and phagocytic cells containing transformed microglia and hematogeneous macrophages (identified by ED1) developed (Figure 2C, F, I). The dynamics of infarct demarcation and astrogliosis did not differ between subcortical and cortical regions at the observation time-points, giving further evidence to the notion that the infarcts developed promptly and in a synchronous way in basal ganglia and cortical areas.
Figure 2. Infarct demarcation and cellular response. H&E (A-C), GFAP (D-F) and ED1 (G-I) staining 24 h, 3 d, and 7 d after infarct induction. The infarct is increasingly demarcated over time by reactive astrocytes that accumulate in the vital tissue bordering the infarct. Scars circumscribe the infarcted tissue but GFAP-positive cells do not enter the infarct zone up to day 7. Phagocytic cells including transformed microglia and hematogeneous macrophages accumulate at the infarct border in the necrotic tissue. Objective: 1×; bar: 200 μm.
The mean ischemic lesion volume of all animals was 161 mm3 ± 90.
The contralateral hemisphere did not show any changes in immunoreactivity at any time point (Figure 2).
Cellular inflammatory response
In the infarct core morphological signs of microglial activation could be shown as early as 24 h after induction of focal ischemia by more intense Ox42-staining. Some amoeboid microglia with rounded cell bodies were also present (Figure 3A, D, G). By day 3, microglia cells started to form a hypercellular rim around the infarct core, exhibiting signs of activation by ED1-staining as an indication for phagocytosis. MHC class II-positive cells with stellate morphology were more numerous and extended further into vital tissue compared to ED1-positive cells. (Figure 3B, E, H). At day 7, a dense cellular wall of microglial cells surrounded the ischemic lesion (Figure 3C, F, I). In the core of the lesion, some - most likely avital - cells exhibited a granular Ox42 immunosignal. There was abundant expression of ED1 and MHC class II-positive cells constituting a rim around the infarct border, with more scattered cells positive for both markers at the infarct core. At day 7, the area of ED1-positive cells (54 mm3 ± 26) extended over 9 to 20% of the affected hemisphere.
Figure 3. Cellular inflammatory response at the infarct border. Phagocytic cells (ED1, A-C), microglia (Ox42, D-F) and activated microglia (Ox6, G-I) are responding to focal cerebral ischemia. Over the course of one week after induction of ischemia, those cells accumulated at the infarct border. Objective: 10×; bar: 100 μm.
The contralateral hemisphere did not show changes in immunoreactivity at any time point.
Cellular interactions in the infarct demarcation zone
7 days after MCAO, eosinophilic coagulation necrosis (Figure 4A) and neuronal degeneration (Figure 4B) could be observed in the infarct core. ED1+ phagocytes (Figure 4C) and activated microglia (Figure 4D, brown) accumulated at the infarct border and interacted with neurons (Figure 4D, red arrows). Astrocytic activation (protoplasmic astrocytes) was clearly visible at the border of the infarct, but not in the infarct core. A demarcation of a scar-like formation could be observed at the periphery of the infarct core (Figure 4E, F) and vimentin immunoreactivity depicted immature astrocytes indicating proliferation of astrocytes.
Figure 4. Cellular interaction in the infarct demarcation zone. Infarct demarcation zone at day 7 after infarct induction (left: healthy tissue; right: infarct zone) with different stainings: H&E (A), NeuN (B), ED1 (C), anti NeuN antibody and anti-Iba1 antibody (D), GFAP (E) and VIM (F). The infarct zone was clearly demarcated (A-F) Eosinophilic coagulation (A) and neuronal degeneration (B) occurred at the infarct. ED1+ phagocytes (C) and activated microglia (D, brown) are visible within the infarct. Interactions between neurons and activated microglia occurred (D, red arrows). GFAP-positive astrocytes (E) demarcate the lesion forming an astrocytic scar in the vital tissue adjacent to the infarct border. Vimentin immunoreactivity (F) depicts proliferating astrocytes within the scar (black arrow) as well as other cell types within the infarct (green arrow). Objective: 40×; bar: 50 μm.
Cytokine response
The proinflammatory cytokines TNF-α, IL-1β, iNOS and IL-18 were quantified in the infarct core and homotopic contralateral regions over time (Figure 1B). Permanent MCAO induced the early upregulation of TNF-α mRNA within the first 4 hours after ischemia. TNF-α stayed upregulated at significant levels for the entire time period studied (Figure 5A). IL-1β and iNOS were upregulated at a slower rate and peaked 72 hours after onset of ischemia (Figure 5B, C). IL-18 expression was detectable at low levels within the first days and peaked at 7 days after stroke (Figure 5D).
Figure 5. Cytokine response. Quantitative real-time polymerase chain reaction (PCR) analyses of TNF-α (A), IL-1β (B), iNOS (C) and IL-18 (D) mRNA levels shows upregulation of all cytokines within specific time windows. A rapid strong induction of TNF-α peaking at 4 h was accompanied by a lower response of IL-1β and iNOS with a maximum at 72 h. IL-18 was induced very late around day 7. At each time point after onset of infarct, n = 5 animals were studied, whereas 4 animals served as control. Bars represent mean ± SD; **p < 0.01; *p < 0.05 (compared to control animals); ++p < 0.01; +p < 0.05 (infarcted hemisphere compared to contralateral hemisphere).
In the macrosphere model, the intra-arterial injection of 4 TiO2 spheres leads to permanent occlusion of the MCA resulting in an ischemic lesion of the MCA-territory [20]. The interindividual variability of infarct volume caused by different occlusion sites of the macrospheres is similar to other embolic stroke models. This technique mimics arterio-arterial embolism of "hard" atherosclerotic plaque material, the most frequent cause of stroke in humans [22,25]. Moreover, in contrast to the well-established suture model of permanent ischemia, the macrosphere model avoids hypothalamic injury and subsequently hyperthermia [18,20,21], while hypothalamic infarction is extremely rare in patients. Hyperthermia may be a confounding factor in therapeutic studies and may influence CNS inflammatory responses as well. In those regards, the macrosphere model offers clear advantages compared to the commonly used transient and permanent suture models, and has therefore been suggested to represent a clinically relevant model to study the pathophysiology of stroke.
In a proof-of-principles study we previously visualized macrophage infiltration in human stroke by a superparamagnetic iron oxide contrast agent (USPIO) [14]. At 3-4 days after stroke onset, we detected subtle contrast enhancement in only a minority of patients. However, 6-8 days after onset of ischemia, we consistently found signs of macrophage infiltration in subcortical as well as cortical areas. Macrophage infiltration heterogeneously affected subregions of the infarct with significant inter-individual differences. This is in accordance with the dynamics of cellular responses after permanent focal ischemia in primates reported earlier [26]. Going back from "bedside to bench", two essential features of cellular responses in the macrosphere model are reminiscent of the human situation: (i) the slowly evolving macrophage infiltration at the end of the first post-infarct week, and (ii) the heterogeneous distribution of the macrophage infiltrate throughout the infarct.
In rodent models of tMCAO, the temporal evolution of tissue damage has also been shown to be heterogeneously, extending in distinct patterns on a subcortical to cortical axis, which renders inflammatory responses complex and difficult to assess [16,17]. Reperfusion accelerates inflammation, facilitating the rapid infiltration of hematogeneous cells, to an early and diffuse accumulation of PMNs throughout the infarct [5-7,27].
In contrast, rodent models of permanent MCAO show rapid signs of tissue damage evolving in the infarct core and succumbing to necrosis, while more peripheral areas display a greater variability in the severity of ischemia. After pMCAO, peripheral areas are usually associated with incomplete necrosis, while subcortical regions show only mild ischemic neuronal damage without loss of neurons [28]. In a rat model of pMCAO, direct surgical occlusion of the MCA led to an accumulation of PMN leukocytes with a maximum at 48-72 hours [16], which is just as late as the PMN infiltration seen after human stroke [7]. In a monkey model of pMCAO, PMNs within the reactive zone could be observed in modest numbers at 18 hours, and increased to 72 hours, while seven-day old lesion showed PMNs in the central infarcted zone only [16]. By comparing permanent and transient MCAO in spontaneously hypertensive rats, the infiltration of neutrophils was moderate in pMCAO. Furthermore, the activity of the neutrophil marker myeloperoxidase was 2 to 3-fold increased, depending of the reperfusion time in tMCAO compared to pMCAO within the first day [27]. Those previous studies suggest that pMCAO models reflect the dynamics of human postischemic inflammation much better than tMCAO models do.
In this study, the extent of ischemic damage obtained by macrosphere embolization corresponded to previous experiments and was comparable to other pMCAO models [18-21]. In contrast, our pMCAO model was different from the previously described photochemically induced focal ischemia model that produces only a pure neocortical infarction [29,30]. While the infarcted area underwent necrosis, the surrounding tissue displayed an increasing astrocyte reactivity over time as revealed by GFAP-staining, a phenomenon that was similar to photothrombosis [30,31]. With respect to the cellular inflammatory response, we observed a transition of ramified into ameboid phagocytic microglia in the boundary zone of the infarct, with consecutive infarct demarcation as late as three days after the induction of ischemia, corresponding to the situation after photothrombosis [29] as well as to that after human stroke [4]. Stoll et al. observed the accumulation of phagocytes in the border zone of human infarcts after 5 days [4]. This combined microglia/macrophage response was accompanied by an up-regulation of MHC class II molecules. In the ischemic core, morphological signs of microglia activation could be detected by day 7, but not at day 1, similar to the photothrombosis model [17,30,32,33]. In human PET studies using the peripheral benzodiazepine ligand [11C]PK11195 as a surrogate marker for inflammation to investigate the temporo-spatial profile of microglia-activation and macrophage-invasion [34-36] and MRI studies using ultrasmall supermagnetic iron oxide (USPIO) to study the invasion of blood-borne macrophages into human brain [12,37], microglia activation in human stroke have been detected to start as late as 3 days after onset of ischemia and reached its maximum within one week [12,34-37]. Interestingly, in the macrosphere model activated microglia and macrophages established a particularly dense cellular wall around the infarct core after 7 days, whereas reactive astrocytes had formed a ring already by day 3, similar to the situation observed in the photothrombosis model [29,31]. The time-course of cytokine release in the macrosphere model differed slightly from the situation in the photothrombosis model. While we found a rapid induction of TNF-α similar to photothrombosis, a much later upregulation of IL-1β and iNOS occurred peaking at day 3. TNF-α and IL-1β are synthesized by PMNs [38] and therefore PMN accumulation may contribute to TNF-α and IL-1β production-besides resident microglia as a principle source-peaking at 72 hours. The induction of IL-18 occurred even later and increased up to day 7. This late induction of IL-18 is in good accordance with the situation previously observed in the photothrombosis model, where the maximum upregulation was found at day 14, a time point not included in our present study [23].
By comparing macrosphere model, human stroke and tMCAO, key features of post-ischemic neuroinflammation, e.g. microglia activation, macrophages infiltration throughout the infarct and phagocytic accumulation, showed a similar temporal appearance in the macrosphere model in rats and human stroke, whereas tMCAO in rats leads to a rapid development of inflammation (Table 1).
Table 1. Cytokine response
The macrosphere model as a model of focal cerebral ischemia resembles closely the dynamics of human postischemic inflammation, imitating particularly the slow time course of human neuroinflammation. Therefore we suggest that the macrosphere model mimics the clinical situation of human stroke better than the commonly used model of transient middle cerebral artery occlusion. Accordingly the rodent macrosphere model is regarded most relevant for studying the pathophysiology of stroke and possesses high clinical relevance.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
MW made the conception and design of the study, carried out animals' surgery, participated in the acquisition of histological and PCR-data, performed statistical analysis of data and drafted the manuscript. MAD participated in the acquisition and interpretation of histological data and helped to draft the manuscript. MLS Simard participated in the acquisition of histological data. SJ participated in analysis and interpretation of PCR-data. GRF revised the manuscript and has given final approval of the version to be published. MS conceived the study, helped with the interpretation of histological data and revised the manuscript critically for important intellectual content. All authors read and approved the final manuscript.
GRF was supported by a grant from the Federal Ministry of Education and Research, Germany: "Brain Imaging Center West" (No. 01 GO 0517).
We thank Birgit Blomenkamp for expert technical assistance for the PCR experiments.
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12:41 PM GMT on September 01, 2012this shot brings me to the fair too!!! just wonderful..AC congrats!! :) |
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Friday August 31, 2012
Falcon Heights, MN (Current Weather Conditions)
Caption: Opening Day of the MN State Fair. Just after Sunset. Long exposure. |
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this shot brings me to the fair too!!! just wonderful..AC congrats!! :) |
Colored shot!Congrats on your beautiful and very interesting new AC! |
Love it, Congrats!! |
Super Minnesota State Fair photo! |
Great shot, congrats. Did you go on anything? |
You can almost smell the funnel cake! Great shot and congrats! |
Oh my, does THAT bring back memories! I sold cotton candy during the fair for several years while I was in college; was a chunk of cash that helped pay my tuition. Other family members did too. Loved it, but you couldn't pay me enough to get me to do it again! Thanks for sharing. Update: Congrats on the AC! |
Every day that I come here, I'm amazed by the awesome photos I see. I love to take photos of whatever catches my eye. Usually my photos have something to do with nature. Insects and flowers have always been a big interest. You can also find me on Flickr. Summer '09 goal: Aiming to take pictures daily, and upload some of my favorites. I hope people enjoy them as much as I do. Most of the time, the fun comes from taking the pictures, more than the actual results. Create your own visitor map! Counter started: 6-21-09


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Scrabble word: ANOLE
In which Scrabble dictionary does ANOLE exist?
Definitions of ANOLE in dictionaries:
- noun - small arboreal tropical American insectivorous lizards with the ability to change skin color
- noun - a tropical lizard
There are 5 letters in ANOLE: A E L N O
Scrabble words that can be created with an extra letter added to ANOLE
All anagrams that could be made from letters of word ANOLE plus a wildcard: ANOLE?
Scrabble words that can be created with letters from word ANOLE
Images for ANOLE
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text: Welcome to Bill Murphy's Internet Cafe for Gold and Silver Investors where the real gold and silver story has been told for the past 15 years! As Chairman of The Gold Anti-Trust Action Committee (GATA) Bill has led the fight against gold market, and other precious metals market manipulation since 1999. Our subscribers benefit from Bill Murphy's unique insight published every trading day in his 'Midas' market commentary. Register for your FREE TWO WEEK TRIAL SUBSCRIPTION TODAY!! |


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67 Cool Blue Bathroom Design Ideas
Wed, Aug 15, 2012 | Bathroom designs |
The whole world is wrapped in soothing sky and vibrant teal oceans. Why not to continue this theme in your own bathroom. We've gathered for you a large gallery of bathrooms in azure, turquoise, sapphire, indigo, cerulean and other shades of blue. These wonderful colors are perfect for a calming and relaxing bathroom and what else do you need after...Continue Reading... { 4 comments }
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71 Cool Green Bathroom Design Ideas
Tue, Aug 14, 2012 | Bathroom designs |
Bathroom in green shades reinforce a theme or complement a time period. You can choose shades from lime to sage because they all looks awesome in a bathroom. If you want your bathroom become a great retreat away from the hustle and bustle of the day we recommend you to choose peaceful shades of green that evoke sense of calm. They works well with wood and...Continue Reading... { 3 comments }
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37 Sunny Yellow Bathroom Design Ideas
Thu, Aug 16, 2012 | Bathroom designs |
Yellow is a great color. For example you can easily make your bathroom more stylish and sunny with it. We've gathered for you a bunch of cool decorating ideas showing how you can do that. Yellow wall paint, yellow shower curtain, yellow floor tiles or any other yellow accents – everything would work great. If you're ready for a lovely and...Continue Reading... { 3 comments }
31 Cool Orange Bathroom Design Ideas
Sat, Aug 18, 2012 | Bathroom designs |
Designing your bathroom in an orange color theme isn't that hard as designing in a red theme but it could be challenging too. You should remember about that you shouldn't combine more than two colors with orange. You should keep orange bathroom simple. The best idea is to simply combine orange with plain white. You can paint walls and ceiling in...Continue Reading... { 2 comments }
39 Cool And Bold Red Bathroom Design Ideas
Fri, Aug 17, 2012 | Bathroom designs |
A color theme in your bathroom speaks to your personality. For example, any bathroom decorate in shades of red would be stylish and bold. It's really tough to work with this color but with some creativity and inspiration you can go with it. We want to help you so we've gathered a gallery of cool red bathroom designs that should provide you with...Continue Reading... { 1 comment }
51 Cool Black And White Bathroom Design Ideas
Wed, Aug 22, 2012 | Other |
Black and white is a quite popular color theme nowadays. You can easily use it in a bathroom to make it look contemporary and stylish. That is easy thanks to the fact that the most bathroom fixtures are white. The perfect thing is that black and white are so contrasting colors that they easily make a bold statement by themselves. You even won't need a...Continue Reading... { 4 comments }
19 Almost Pure Black Bathroom Design Ideas
Tue, Aug 21, 2012 | Bathroom designs |
You won't find pure black bathroom in many houses. It's really hard to find all tiles, furniture, vanities, and accessories in this color. Although almost pure black bathroom are easier to design. Nevertheless they are also very rare. A black bathroom isn't very practical but it's definitely make a statement. If you want to make your...Continue Reading... { 3 comments }
35 Amazing Raw Stone Bathroom Design Ideas
Fri, Aug 31, 2012 | Bathroom designs |
A lot of contemporary don't look too natural. All these modern tiles, furniture, lights, hardware are great but they can make a bathroom plain and boring. Adding some natural elements is a great way to make such bathroom look gorgeous. For example, raw stones can change an overall appearance of the bathroom in a moment. The cool thing is that there...Continue Reading... { 3 comments }
43 Calm And Relaxing Beige Bathroom Design Ideas
Thu, Aug 30, 2012 | Bathroom designs |
Beige is one of those colors that are perfect for a bathroom. Of course a lot of beige bathrooms are boring but in the gallery that we've gathered you'll find a lot of ideas to make your beige bathroom stylish. Even neutral theme does not have to be boring. Thoughtful decor, cozy rugs, beautiful artworks and good furniture could make your...Continue Reading... { 3 comments }


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Related Articles: Restaurants, All |
Jai YunShanghainese Sensationsby Amy Sherman on Jun 01, 2006Restaurants in Shanghai serve food from different parts of China including seafood from coastal regions such as Jiangsu, Zhejian and spicy dishes from Hunan. Shanghai cooking is said to require the most skill and diners eat many small courses of refined dishes in one sitting. Often one ingredient plays the starring role in balanced, clean tasting dishes, as opposed to the one-pot style stir-fry served with a sauce over rice. Knowing all of this will help you to appreciate your Shanghai-style meal at Jai Yun, because eating at Jai Yun is an adventure. Jai Yun is not a restaurant that you stumble into from the street. It sits a few blocks above the bustle of Stockton Street on Pacific Avenue. The restaurant serves only prix fixe menus, and reservations are required. No walk-ins. A prix fixe menu is one thing, but at Jai Yun there is no menu. Something approaching a menu is on the web site, but the number of dishes and exactly what you will be served, is decided upon by the chef, based in part on the number of diners as well as prix fixe price. The prices range from $45 to $150 per person. Whichever price you choose, you will be surprised and probably delighted with most of the seemingly never-ending courses of meticulously prepared dishes at Jai Yun. Some of the dishes are familiar such as Kung Pao Chicken or Orange Beef, but most are more unusual such as Foo Yung Abalone or Celery with Five Spices and Dry Tofu or Cilantro Salad. Jai Yun is certainly a restaurant to try with a group. For the $65 per person prix fixe our table of six received eleven cold appetizers and a progression of fourteen main dishes that began with mild dishes and ended with spicier ones and lasted two full hours. The cold appetizers are each small portions, but intensely flavored so you really only want a couple of bites of each. The flavors and texture range from spicy, juicy, preserved radish green to starchy, crisp, sweet lacy lotus root. In each dish the knife work is astounding. Thin tiny slivers of vegetables and meats are not just impressive to look at but perfectly cooked. Ingredients are enhanced rather than overwhelmed. Some of the most outstanding dishes we enjoyed included the aforementioned Foo Yung Abalone. If you've ever thought cotton candy tasted like a cloud, wait till you try this dish. Fluffy puffs of egg white are mixed with thin slivers of abalone. The mild sweet mollusk is heavenly light and delicate. We also had a whole grouper deep-fried and served with a perfectly balanced sweet and sour sauce. Not the typical cornstarch thickened sauce but a thin, tangy accompaniment to the crunchy and yet tender fish. The sweet Crispy Eggplant with Scallions was soft and sweet, almost like candy and about as addictive. Very few dishes were disappointing, though one was marred by the addition of starchy frozen peas. While most of the food will impress, much of the rest of the experience may be confounding. For a restaurant serving elegant meals, the decor is terribly drab. Though the restaurant was recently closed for renovations, it's hard to tell exactly what improvements have been made. Disco lights and tacky ribbons sadly serve as a distraction from the main event, the food. The dishes are complex and sophisticated, and yet the server sometimes clueless about them. But find a group of adventurous eaters, and go anyway. Chinese Chinatown $$$$ Reservations Essential? Yes by Amy Sherman on Jun 01, 2006 |
Photo credit: Amy Sherman Photo credit: Amy Sherman |


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Riverland Resorts
Phone: (559) 897-5166
Visit Campground Website
Sites: 100
Recent Rate: $30 12/2013
Latitude: 36.4945437799803
Longitude: -119.527795314789
These reviews are the opinion of an RVParkReviews' member and not the views of RVParkReviews.com
Date of Stay: December, 2013 - $30.00
We stayed 1 night while driving north. Friendly and helpful staff. Road is paved, site was on grass/dirt and somewhat level, long enough for 5er & truck and wide enough for slideout and awning. Hookups are very basic and working. WiFi was available, not fast and cutting out. Restrooms are there but I would not use them, look old, are old and could be way cleaner. Constant noise from I-5, not really bad but always present. It looks like there are a few longtimers in this park and it definitely could use some updates. We stayed as it was time to stop and because we couldn't find an earlier RV Park. I will not return. We camped at Riverland Resorts in a Fifth Wheel.
Date of Stay: October, 2013 - $20.00
I lived in a cabin here for over a year and saw this "resort" literally fall apart in that time. They advertise a lake and fishing, but the lake dried up and all the fish were left to die and rot. They advertise wifi, and only a select few sites within the short antenna range can get it. They advertise ckean restrooms and showers and they are not. They advertise pool and jacuzzi, but the jacuzzi has been broken since spring of 2013. Nothing gets repaired, except for the restaurant bar, and that's a lot of fun on weekends with all the obnoxious drunks allowed to run around the park disturbing residents. There is no security, and the assessment fees we as residents pay gets us nothing but our holding tanks pumped out, and that is even hit and miss. The only thing that kept me there was the fishing, and now all that is left of that is the rotting carcases that the grounds crew refused to clean up. If I had to pull in here for an emergency, I would probably use the rest stop across the highway. Stay away and maybe the owner will clean up the park and concentrate on the resort instead of the restaurant. We camped at Riverland Resorts in a Campground Cabin.
Date of Stay: May, 2011 - $44.00
This park is far from a "Resort." Upside, it's pretty family friendly. Playground, pool/spa, basketball court, clubhouse. Downside, it's very run down. We were to get a shady grass spot, but most of the sites are on concrete with no trees, which could be VERY HOT in our Valley Summers. Also, there are no fire pits or BBQ's. Picnic tables are very scarce and "first come, first served." There is not even one table per site, which is kind of annoying. This park was definitely WAY over priced. We camped at Riverland Resorts in a Travel Trailer.
Date of Stay: December, 2008 - $27.00
We arrived after hours and found good instructions on where to park. Found a grassy pull-through. This park is close to both the freeway and the train tracks so, you have to expect that its rather noisy. The pedestal that was at our site was in disrepair. I was alarmed at the corrosion on the breaker switch. The last occupant had duct taped their sewer hose into the outlet and left the tape. We didn't dump so not critical to us. OK for overnight stop. We camped at Riverland Resorts in a Fifth Wheel.
Date of Stay: April, 2008 - $35.00
This park needs some major clean up.for 35 bucks a night expect a lot more than a messy site, kids toys, garbage, ect. Bathrooms are scary, paid for full hook up couldn't use the sewer to dump overflowing and gross..we wouldn't stay here again or recommend it to anyone. We camped at Riverland Resorts in a Travel Trailer.
Date of Stay: November, 2006 - $24.00
What a dump. I'm sorry but pictures are so deceiving and this posting things that are not really real on rv park sites should be illegal. When we drove up we were scared. Ok maybe not that bad but enough where we only got out of the rv that evening to park and the next day to sit by the water and study. I didn't go near the restrooms. The lake is, well I guess you can call that a lake and the opposite end of it was so nasty and green I can't believe some don't get infections from bug bites. I hate being harsh but after 6 years of rv'ing I am getting so tired of making excuses for these parks. If you go here, be armed! We camped in a motorhome 36' and had just enough room to pull our slideouts out. We camped at Riverland Resorts in a Motorhome.
Date of Stay: February, 2006 - $50.00
This park is overrated and crowded. All the river sites have been leased out with a trailer (cabin). We stayed on one of the few sites left on the river. The bar played loud music, booming bass, until 1AM. We couldn't get to sleep. You can also hear busy Highway 99 from the park. We camped at Riverland Resorts in a Motorhome.
Date of Stay: July, 2005 - $25.00
Agree with previous comment on this site. We paid $25 to park on uneven, non level grass. Pull through sites were in the middle of nowhere. River front sites, without electric or sewer were listed at $65 per night. Location is right next to, practically on, highway 99. Terribly noisy all day and all night. No one slept well. We camped at Riverland Resorts in a Fifth Wheel.
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Boston, Mass. A new study shows that when a liver from a deceased adult or adolescent donor is split into two separate portions for transplantationwith the smaller portion going to a young child and the larger to an adultthe smaller portion used for the child will last just as long as if the child had received a whole organ from a donor close to his size.
The data, collected and analyzed by a team led by Boston Children's Hospital researchers Heung Bae Kim, MD, and Ryan Cauley, MD, MPH, was published online in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Data on graft survival and mortality for adult recipients of split livers is currently being compiled for a separate study to be released soon.
Examining pediatric data provided by the United Network of Organ Sharing (UNOS), the authors researched the mortality and graft survival of 2,679 patients under the age of two who received liver transplants between 1995-2010. Of these cases 1,114 involved partial livers and 1,565 involved whole organs. Their research indicates that from 1995- 2000 partial grafts had a higher risk of failure, but from 2000-2006 that risk was lower, indicating partial liver transplants became safer as experience with this practice increased. By 2006 both split and whole organs had similarly low rates of both graft failure and mortality, suggesting that their use could be increased to meet the demand for smaller grafts.
"Infants and young children have the highest risk of death on the liver transplant waiting list, mainly due to the shortage of appropriately sized organs," says Kim, senior author on the study and director of Boston Children's Pediatric Transplant Center. "But based on this new data, split liver transplantation may prove to be the answer to this difficult problem. If more liver donors were made available for consideration as split liver
Contact: Keri Stedman firstname.lastname@example.com 617-919-3110 Boston Children's Hospital Source:Eurekalert |


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Assessment of RELAP5/MOD3.3 against Single Main Steam Isolation Valve Closure Events at the Krško Nuclear Power Plant (NUREG/IA-0223)
On this page:
Download complete document
Publication Information
Manuscript Completed: November 2003
Date Published: April 2010
Prepared by:
Iztok Parzer, Borut Mavko
Jožef Stefan Institute
Jamova cesta 39
SI-1000 Ljubljana, Slovenia
A. Calvo, NRC Project Manager
Published by:
Office of Nuclear Regulatory Research
U.S. Nuclear Regulatory Commission
Washington, DC 20555-0001
Recently, the last frozen version of RELAP5/MOD3.3 was released, before the code will be merged with another best estimate thermal-hydraulic system code (TRAC) into an integrated thermal-hydraulic code. Therefore, it is of utmost importance to assess models built using the RELAP5/MOD3.3 code against real plant transients before the code merger.
The paper presents the RELAP5/MOD3.3 analysis of two abnormal events that occurred at the Krško Nuclear Power Plant in September 1995 and January 1997, before replacement of the steam generators (SGs) in 2000. The events resulted from the sudden closure of a main steam isolation valve (MSIV). In the September 1995 event, a malfunction in the MSIV in SG-1 caused inadvertent valve closure. In the January 1997 event, the valve stem in SG-2 was broken, also causing sudden valve closure. Researchers obtained valuable plant data from these real plant transients and performed the RELAP5/MOD3.3 code assessment.
The analyses used a full two-loop plant model, developed at the Jožef Stefan Institute in Ljubljana, Slovenia. The model assumed old Westinghouse D4-type SGs with preheaters. It assumed that 18-percent of the U-tubes were plugged in both SGs.


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Your debut, 19, was such a smash-were you afraid of the sophomore slump when you recorded 21?
Yes. I didn't know what to write. Luckily I broke up with my ex-that's good material. But I was insecure because it's so personal, you know?
How did you survive the breakup?
I locked myself in my house for nine months, drank four bottles of wine a night and listened to Bonnie Raitt's "I Can't Make You Love Me."
Who's your ideal guy now?
I'd rather date an ugly, hilarious guy than Leonardo DiCaprio. Humor keeps relationships together.
Would you prefer to settle down with a Brit over an American?
American men don't get my humor-it's very dry and sarcastic. Ideally I'd be with an English guy who lived in England because I hate flying. On a plane I'm convinced I'm going to die, so I call and text everyone I love.
How has your style changed?
I didn't have a stylist for the first [album], so it was a lot of comfort jumpers and leggings. Now I have a stylist who knows my figure and knows how I feel about my body.
How do you feel about it? Have you been pressured to diet?
I've never wanted to look like the models on magazine covers. I wasn't brought up like that. I hate when something is all visual and not about the music. I'm not one of those artists, so I don't have the pressure. But I still have hang-ups. I sometimes wake up and hate myself just like anyone else does, sometimes for my body, sometimes for a drunk text I sent. But even before I sold any records, I always stood up for myself!
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Ab-initio multiplet calculation of oxygen vacancy effect on Ti-L2,3 electron energy loss near edge structures of BaTiO3


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Amanda Baker
Nonprofit Manager
R. Scott Barber
Regional President, Mid-South
Kelley Brown
Candice Brown
Senior Director, HR Strategic Partner
Marc Calabrese
Research Scientist
Lindsay Chason
Associate Merchant
Louis Chen
Program Manager
Jamie DeMaria
Vice President of Education Marketing and Strategy
Sharif El-Mahdi
Julia Lee Elliot
Sean Farrell
Medical Device Sales Representative
Chris Fleishman
This will only take a minute.
The following questions will help us get a better understanding of your background and whether you are a good fit for the MBA@UNC program.
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I talked to several players about the large contingent of Fresno State fans at the game, and how upon coming out of the tunnel before the game the Bruins looked into the north end zone, which was a sea of red.
"I don't like red," UCLA defensive tackle Brian Price said. "I'm like a bull out there. In the paper (Fresno coach Pat Hill) said he was going to paint the Rose Bowl red, so they brought a lot of fans. I was ready for it."
Bruins linebacker Reggie Carter was more diplomatic.
"I know Fresno isn't that far so I was expecting to see a lot of Fresno fans," Carter said. "They had that whole end zone. But to, it doesn't matter if it was blue, purple, pink; I was still going to play the same way."


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I'm trying to record vocals but it doesn't seem to be working.
I plugged my microphone into the pod mic input then turned on the phantom power to power my condenser microphone and then went on a new tone with nothing on it. my pod unbalanced outputs are plugged into my speakers (like normal) and the pod is connected to my daw by usb but when i arm the track it picks up no audio at all but the little green signal light on the pod is flashing when i talk into the mic haha
someone please help me!


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Title: | State of the City: Homeless Policy & Programs in NYC |
Publication Date: | 02/08/11 |
Description: |
The Wagner Policy Alliance presents its annual State of the City event. The 2011 program features a panel discussion on homelessness in New York City. The panel, moderated by Professor Ingrid Ellen, brings together national and local experts for a conversation on homelessness and housing assistance. In 2004, Mayor Michael Bloomberg made national news by announcing that his administration would work towards reducing homelessness in New York City by two-thirds during his tenure as mayor. |
Author: | NYU Wagner |
Links: |
Original Event Information |
Play/Download MP3: |
MP3 Duration: | 1:14:35 |
MP3 Filesize: | 30.54 MB |


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Rupert Brooke
Rupert Brooke
(1887-1915 / Warwickshire / England)
Choriambics Ii
Here the flame that was ash, shrine that was void,
lost in the haunted wood,
I have tended and loved, year upon year, I in the solitude
Waiting, quiet and glad-eyed in the dark, knowing that once a gleam
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Recruiting News Recruiting Jobs Recruiting Social Network Human Resources
Fed up with sub-standard Resumes and CV's, even from top people? Point them to LinkedIn's hidden resume builder at http://resume.linkedinlabs.com. It's saved my candidates bacon more than once. It converts their LinkedIn profile into a pretty decent document double-quick, and they can still edit it and choose from a range of templates. I'm a Newbie on this platform, so for all I know you lot ha…
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