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US 5201754 A Abstract A balloon dilatation catheter, usable in percutaneous transluminal angioplasty, is formed so that portions of the catheter both distally and proximally of the balloon have varyinq degrees of radiopacity. A portion of the catheter distally of the balloon presents a dark image under fluoroscopy while a portion located proximally of the balloon displays a moderately radiopaque image under fluoroscopy. The portion of the catheter in the region of the balloon may have a moderate, light or no radiopaque means.
Claims(11) 1. A balloon angioplasty catheter comprising:
an elongate longitudinally flexible tubular proximal segment having a proximal end and a distal end; an elongate distal segment extending distally beyond the distal end of the proximal segment, the distal segment being shorter and more flexible than the proximal segment and having nonuniform radiopacity; a balloon carried by the distal segment; the tubular proximal segment defining a lumen for communicating the proximal end of the catheter with the interior of the balloon to enable inflation and deflation of the balloon; the distal segment comprising a support wire having a smaller diameter than the outer diameter of the distal end of the proximal segment and a highly radiopaque means carried by the support wire distally of the balloon; moderately radiopaque means carried by the support wire proximally of the highly radiopaque means and extending along a substantial length of the support wire; the balloon being supported on the support wire with the support wire extending through the balloon; means for communicating the lumen of the proximal tubular segment with the interior of the balloon; the proximal segment and support wire being sufficiently torsionally rigid so that when the catheter is in a configuration corresponding to that of a human aortic arch and with the distal segment in a coronary artery, the catheter is capable of transmitting controllably from its proximal to its distal end rotation applied at the proximal end. 2. A balloon angioplasty catheter as defined in claim 1 wherein the moderately radiopaque means extends through the balloon.
3. A catheter as defined in claim 1 wherein the moderately radiopaque means extends from the proximal end of the balloon toward the proximal end of the shaft and along a substantial portion of the catheter;
the region of the balloon being substantially free of radiopaque means. 4. A catheter as defined in claim 1 wherein the catheter is dimensioned and adapted to be inserted into the coronary arteries.
5. A catheter as defined in any one of claim 1-3 wherein the moderately radiopaque means comprises a plating of radiopaque material on the elongate flexible support wire.
6. A balloon angioplasty catheter as defined in any one of claim 1-3 wherein the moderately radiopaque means comprises a cladding of radiopaque material on the support wire.
7. A catheter as defined in any one of claims 1-3 wherein the support wire is formed from a moderately radiopaque material.
8. A catheter as defined in claim 5 further comprising a short highly radiopaque element carried by the catheter adjacent the proximal end of the balloon.
9. A catheter as defined in claim 5 wherein the distal segment is between about 25 cm to 35 cm in length.
10. A balloon catheter as defined in claim 6 further comprising a short highly radiopaque element carried by the catheter adjacent the proximal end of the balloon.
11. A catheter as defined in claim 6 wherein the distal segment is between about 25 cm to 35 cm in length.
Description This application is a continuation in part of application Ser. No. 303,908 filed Jan. 30, 1989, now U.S. Pat. No. 4,917,088 which was a divisional of application Ser. No. 729,541 filed May 2, 1985 now U.S. Pat. No. 5,102,390. This invention relates to improvements in catheters for performing balloon angioplasty procedures in stenosed blood vessels. Balloon angioplasty procedures have been used in recent years with increasing success in the treatment of obstructed arteries, such as the coronary arteries. The procedure involves advancing a catheter having a special balloon at its distal end to the location of the stenosis. The balloon portion of the catheter is placed, in its deflated condition, in the stenosis and then is inflated under high pressure to compress radially and outwardly the biological material such as plaque which forms the stenosis. Balloon dilatation systems of this type are illustrated in U.S. Pat. Nos. 4,195,637 and 4,323,071. In those situations in which balloon angioplasty can be used, its successful use avoids the greater risk of complex and expensive bypass surgery. Not all arterial stenoses are treatable by balloon angioplasty. Among the types of vascular obstructions which have not been treatable with the angioplasty technology are those in which the passage through the stenosis is so narrow that the balloon angioplasty catheter cannot be inserted into the stenosis, even when the balloon is in its collapsed, deflated condition. Thus, where the opening in a stenosis was only enough to permit passage of a guide wire, but not enough to permit passage of a deflated angioplasty balloon, the procedure could not be performed. In order to enable balloon angioplasty to be performed in such narrowly stenosed arteries, low profile dilatation catheters have been developed. The low profile dilatation catheters typically are capable of assuming relatively low cross sectional dimensions, particularly in the region of the balloon, so that when the balloon is deflated, it may be inserted, in that configuration, into a tight stenosis. Typically, such low profile dilatation catheters incorporate a fixed guidewire as an integral part of the catheter. The guidewire forms part of or extends through the catheter and facilitates manipulation of the catheter so that it can be steered through branches in the patient's vasculature. Among the significant advances in such low profile catheters is that disclosed in U.S. patent application Ser. No. 303,908 filed Jan. 30, 1989. The probe-like catheter described in application Ser. No. 303,908 is very small in diameter and has a small diameter thin walled balloon at its distal portion. The catheter is constructed and arranged to be advanceable through the patient's vascular system and can be controlled and manipulated from its proximal end so that it can be steered selectively at forks in the vascular system. The main body of the catheter includes a flexible elongate hollow main shaft adapted to transmit torque from a proximal to the distal end of the catheter. The smaller diameter balloon support wire is attached to and extends from the distal end of the flexible hollow shaft. A helical spring is mounted to the distal portion of the support wire. The dilatation balloon is attached at its proximal end to the distal portion of the main shaft and the distal end of the balloon is attached to the proximal end of the helical spring. An inflation/deflation port is formed in the hollow main shaft distally of the proximal balloon connection to communicate with the interior of the balloon for inflating and deflating the balloon. A distal segment of the catheter which projects beyond the balloon includes the helical spring and a portion of the support wire. The support wire is tapered within the helical spring to provide progressively increasing flexibility in a distal direction. The distal end of the distal segment is adapted to be bent to a curve and enables the catheter to be selectively directed and steered by rotating the catheter from its proximal end. The balloon is very thin. The diameter of the collapsed folded balloon portion of the catheter is very small and defines a very small profile. In order to enable steering of the catheter, a distal portion of the catheter is formed from a highly radiopaque material so that it is readily observable under X-ray fluoroscopy. Typically, such catheters have included radiopaque elements in the distal segment of the catheter, distally beyond the balloon. Additionally, small radiopaque markers may be disposed at other locations along the catheter to enable fluoroscopic determination of the location of other portions of the catheter, such as the proximal end of the balloon. In the catheter described in aforementioned application Ser. No. 303,908, the helical spring in the distal segment of the catheter is formed from a highly radiopaque alloy so that it appears quite dark on the fluoroscopic screen. Although providing a highly radiopaque portion of the catheter distally of the balloon is important in positioning the catheter, it is relatively short and provides relatively little indication of the shape and configuration of the artery or arteries in which the catheter is disposed. The configuration of the patient's coronary anatomy is important to the physician. Typically, during an angioplasty procedure, the physician will cause a radiographic contrast liquid to be emitted into the arteries being treated that so for a brief interval, the contour and anatomy of the arteries may be observed. Often the physician also activates a camera to make a permanent, replayable recording of the coronary anatomy. The injection of radiopaque contrast liquid also enables the physician to examine and determine the location and nature of the stenosis or stenoses to be treated. Although it would be desirable for the physician to have a continuous fluoroscopic indication of the coronary anatomy, that cannot be done because it would require continuous infusion of radiopaque contrast liquid. The amount of radiopaque contrast liquid that can be infused into a patient is limited. Therefore, it is believed that there is a need for a means by which the coronary anatomy may be observed continuously but without requiring continuous use of radiopaque contrast liquid. It is among the objects of the invention to provide a balloon dilatation catheter which facilitates fluoroscopic observation of the coronary anatomy through which a substantial portion of the catheter is disposed. In accordance with the invention, the catheter, proximally of the highly radiopaque distal segment, is modified to include a moderately radiopaque material extending along a substantial portion of the distal length of the catheter at and proximally of the balloon. The moderately radiopaque portion which trails the highly radiopaque portion thus is observable as a light but discernible shade of grey and enables the physician to observe the contours and paths of the coronary anatomy through which the balloon has been placed. Additionally, by providing only a moderate radiopacity, the physician also may infuse radiopaque contrast liquid to observe further details of the coronary anatomy. By providing only a moderately radiopaque segment, there is no interference with the physician's observation of such details. More particularly, in the present invention, the balloon support wire is coated with a thin film of radiopaque material, such as gold, to a degree sufficient to form a light grey, but discernible image on the fluoroscope. In a modification of the invention, the portion of the balloon support wire that extends through the balloon is not rendered radiopaque so that when the physician infuses radiopaque liquid into the region of the stenosis, where the balloon is located, no radiopacity will be caused by the balloon support wire. In that configuration, all of the radiopacity will be the result of the radiopaque contrast liquid, thus providing the physician with the most detailed, unobstructed picture possible. Thus, it is among the general objects of the invention to provide a balloon dilatation catheter that is adapted to provide a radiopaque image, in varyinq shades of intensity, of a substantial portion of the arterial anatomy both proximally of and distally of the dilatation balloon. A further object of the invention is to provide a catheter of the type described in which different portions of the catheter display different intensities of radiopacity under fluoroscopic observation. The foregoing and other objects and advantages of the invention will be appreciated more fully from the following further description thereof, with reference to the accompanying drawings wherein: FIG. 1 is a longitudinal, fragmented illustration of the dilatation catheter; FIG. 2 is an enlarged longitudinal section of the portion of the dilatation catheter which includes the transition region from the proximal segment to the distal segment; FIG. 2A is a cross-sectional illustration of the transition tube as seen along the line 2A--2A of FIG. 2; FIG. 3 is an enlarged longitudinal sectional illustration of the balloon portion and distal segment of the dilatation catheter; FIG. 3A is a sectional illustration of the catheter balloon as seen along the lines 3A--3A of FIG. 3; FIG. 3A-1 is an illustration of the catheter balloon of FIG. 3A in an evacuated, collapsed configuration; FIGS. 3A-2 and 3A-3 are illustrations of the collapsed dilatation catheter balloon with its wings wrapped about the support wire in an S-shaped configuration and a C-shaped configuration, respectively; FIG. 3B is a sectional illustration of the sleeve extension of the catheter when the catheter is in an inflated condition; FIG. 3B-1 is an illustration of the sleeve of FIG. 3B when in an evacuated, collapsed configuration; FIG. 4 is an enlarged sectional illustration of the juncture of the balloon and the balloon extension sleeve; FIG. 5 is a greatly enlarged cross sectional illustration of the core wire of the catheter illustrating, in exaggerated thickness, its radiopaque coating; FIG. 6 is a cross-sectional illustration, in exaggerated detail, of a support wire clad with a radiopaque material; and FIG. 7 is a cross sectional illustration, in exaggerated detail, of the distal end of a balloon catheter having a support wire with a tapered distal portion and including a segment clad in radiopaque material. FIG. 1 illustrates a low profile balloon dilatation catheter adapted for use in the coronary arteries. The dilatation catheter 12 is of very slender construction having a cross-section approximately equal to that of a small diameter guide wire. The dilatation catheter 12 has a balloon 26 which, when collapsed, defines a small cross-sectional configuration so that it can pass through tight stenoses. In its collapsed configuration the balloon 26 as well as the remaining portions of the catheter 12 define an outer diameter corresponding to that of a small diameter guide wire. It should be understood, however, that the invention may be incorporated in catheters of other sizes as well. The catheter 12, illustrated in FIG. 1, is of the order of about 150 centimeters when used in coronary arteries with a percutaneous femoral artery approach. The catheter 12 has a relatively long proximal segment 28 which is formed from narrow, solid wall tubing, such as hypodermic tubing. In the illustrative embodiment, the proximal segment 28 may be of the order of 120 centimeters long. The proximal segment 28 is rigid torsionally so that it can transmit substantially fully to its distal end rotational motion imparted to the proximal end. As will be described, the distal tip of the catheter can be bent to a preset curve. Rotation applied to the catheter can be controlled to selectively direct and steer the curved distal end of the catheter as it is advanced. The proximal segment 28 also is flexible and can bend longitudinally to follow the curvature of the patient's arterial system. The proximal segment 28 of the catheter 12 may be sufficiently flexible that it can bend to follow the curve of a patient's aortic arch which has a radius of the order of between 2.5 to 3.5 inches in an adult. Alternately, it may be preferred to select a length for the proximal segment 28 so that it need not pass through the aortic arch. As shown more clearly in enlarged FIG. 2, in the preferred embodiment of the invention the hollow tubular segment 28 has an outer diameter of 0.022 inches, a wall thickness of about 0.003 inches and an internal diameter passage 30 of 0.016 inches. A conventional fitting 32 is secured to the proximal end of segment 28 to facilitate connection with an inflation/deflation device, such as a syringe (not shown). The catheter 12 includes a distal segment 34 which extends from the distal end of the proximal segment 28 to the distal end of the catheter 12. The distal segment 34 includes a narrow diameter elongate support wire 44 which is connected to and extends distally of the proximal segment 28. The support wire 44 is connected to the proximal tubing 28 by a short transition tube 36. The transition tube 36 is about three inches long and also is formed from slender, flexible hypodermic tubing with a smaller diameter than the proximal tube 28. In the illustrative embodiment, the transition tube 36 is formed from hypodermic tubing having an outer diameter of 0.015 inches, a wall thickness of 0.0035 inches and an inner diameter of 0.008 inches. The proximal end of the tubing 36 is received within the distal end of the internal passage 30 of the proximal segment 28 and is secured thereto as by soldering or brazing. The solid support wire 44 is attached to the distal end of the transition tube 36. The support wire 44, which in the illustrative embodiment is very slender, preferably 0.008 inches diameter, is received in the distal end of the passage 38 of the tubing 36 and is secured by soldering or brazing. The support wire 44 plugs the distal end of the tubing 36. In order to permit the balloon 26 to be inflated and deflated, the transition tube 36 is provided with apertures 46 on opposite sides of the tube wall to provide communication with the internal passages 38, 30 of the catheter. The apertures 46 may be defined by forming a pair of oval ports about 0.005�0.020 inches in the wall of the tubing 36. The support wire 44 provides support for the balloon 26 and also extends distally beyond the balloon 26, to form the core of a leader segment 48. The leader segment includes a helically wound radiopaque coil spring 50 which is attached to the distal end of the core wire 44 in a manner described below. The coil 50 may be formed from a platinum alloy, having a high percentage of platinum. The balloon 26 is formed by molding high strength polymeric material in a manner which provides a thin balloon wall not greater than about 0.001 inches thickness and, preferably, having a thickness of the order of 0.0005 inches. The balloon may be manufactured as described in U.S. Pat. No. 4,490,421 issued Dec. 25, 1984 and reference is made thereto for further details concerning the manufacture of the balloon. As shown in enlarged detail in FIG. 3, the balloon includes a main cylindrical portion 52. In the illustrative embodiment, the balloon 26 preferably has an outer diameter of 2.0 to 4.0 millimeters. As mentioned above, the balloon is formed from a high strength material which will not tend to stretch when inflated. The length of the balloon 26 may be of the order of 15 millimeters. The balloon is formed to include tapering portions 54, 56 at the proximal and distal ends respectively. The distal tapering portion 56 merges into a narrowed neck 58 which fits snugly about and against the proximal end of the coil spring 50. The distal neck 58 of the balloon 26 is adhesively attached to the coil spring 50. As will be described in further detail, the proximal end of the coil spring is soldered securely to the core wire at the region where the distal neck 58 of the balloon 26 is joined. The proximal tapering portion 54 merges into a narrowed proximal neck 60. In order to communicate the interior of the balloon 26 with the inflation/deflation passages 30, 38 of the tubing, an extension sleeve 62 is adhesively attached to the proximal neck 60. The extension sleeve 62 extends proximally over the support wire 44. The proximal end of the extension sleeve 62 preferably is formed from the same material as the balloon 26 and is securely and adhesively attached to the outer surface of the transition tube 36, where it joins the main tube 28. The extension sleeve 62 defines an annular passage 64 about the support wire 44. The annular passage 64 provides communication between the apertures 46 and the interior of the balloon 26 for inflation and deflation of the balloon. As shown in FIG. 3 the leader segment 48 which extends distally of the balloon 26 is of increasing flexibility in a distal direction to provide a relatively soft, flexible leading tip which reduces the chance of trauma or injury to the blood vessel. In the illustrative embodiment the leader segment is about 3 centimeters long. The coil spring 50 is soldered, at its proximal end to the support wire 44, as indicated at 66. The distal end of the support wire 44 also is soldered to the coil spring 50 as indicated at 68. Soldered joint 68 and the distal tip 69 of the support wire 44 terminate short of the distal tip of the coil spring 50. The distal tip 70 of the coil spring 50 may extend about five millimeters beyond the soldered joint 68 and defines a highly flexible bumper tip. A rounded weld bead 67 is formed at the distal tip of the spring 50. The leader segment 48 is of increasing flexibility in a distal direction. The support wire 44 is taper ground and, for example, may be ground smoothly to a 0.002 inch diameter at its distal tip 69. The distal tip 70 of the coil spring 50 includes a flexible and bendable stainless steel shaping ribbon 71 which is secured to the distal tip 69 of the support wire at one end, and to the distal weld bead 67 at its other end. The shaping ribbon is of slender, rectangular cross section, of the order of 0.001 inches by 0.002 inches. The shaping ribbon is adapted to be bent to a desired curve and to retain that curve when relaxed. The preset curve enables the catheter 12 to be steered by rotation of the catheter from its proximal end. The catheter can be rotated to direct the prebent distal tip 70 in selective directions as desired within the patient's blood vessels. The catheter also is provided with a radiopaque marker band 72 which preferably is formed from platinum. The marker band 72 is located proximally of the main portion of the balloon 26. In the illustrative embodiment it is securely attached to the support wire 44. The marker band 72 provides a means by which the physician can verify, fluoroscopically, the position of the balloon 26. In order that the catheter may be passed through the lumen of a catheter which may guide the balloon catheter to the coronary arteries, the balloon 26 also must be collapsible to a shape and size which can be passed through the lumen of that guiding catheter. The invention accomplishes these objectives by using the slender, small diameter support wire 44 extending through the balloon and by using a balloon with a very thin but high strength wall. When the catheter 12 is to be inserted through the guiding catheter, the balloon 26 first is collapsed by applying suction, such as by a syringe, to the fitting 32. The balloon 26 and the extension sleeve 62 collapse, tending to form radially projecting wings as illustrated in FIGS. 3A-1 and 3B 1, respectively. The wings 62W and 26W wrap about the support wire 44 when the catheter is advanced through the main lumen of the guiding catheter. The wings 26W may wrap about the core wire 44 either in an S shaped configuration suggested in FIG. 3A-2 or in a C-shaped configuration shown in FIG. 3A-3. In either configuration the overall diameter through the collapsed and folded balloon portion of the catheter 12 includes six layers of the balloon material in addition to the diameter of the support wire 44. The balloon is formed from a high strength thin material having a wall thickness preferably not more than about 0.001". Thus, the aggregate diameter of six balloon layers plus the support wire is about 0.014 inches. The balloon thus is collapsible to a diameter which is about one fourth of its inflated diameter and which can pass easily through the main lumen of the guiding catheter. In use a larger diameter guiding catheter through which the dilatation catheter 12 can be passed is inserted initially in the patient's arterial system, usually through the femoral artery, and is advanced through the aortic arch to locate the distal tip of the guiding catheter at the coronary ostium leading to the coronary artery or into the coronary artery to be treated. After the larger guiding catheter has been positioned the catheter 12 is advanced through the larger catheter with its balloon 26 in a collapsed configuration. The diameter of the catheter 12, in the illustrative embodiment, is about the same as a conventional guide wire. The dilatation catheter 12 thus can be advanced out of the distal opening of the guiding catheter with the balloon 26, in its collapsed configuration, and by advancing and rotationally manipulating the catheter through the patient's artery, can be inserted into and through the stenosis. The dilatation balloon 26 then may be inflated under pressure to expand forcefully the balloon 26 to its maximum diameter thereby enlarging the passageway through the stenosis. When the balloon 26 has been inflated to enlarge the opening through the stenosis the balloon 26 is collapsed by aspirating the balloon. The catheter then may be withdrawn from the patient. As described above, the catheter 12 is very flexible through its distal segment 34. The proximal segment 28 may be sufficiently flexible so that it can bend relatively easily through the aortic arch. It may be preferred, however, to dimension the catheter so that the juncture of the proximal segment 28 and distal segment 34 will be disposed proximally of the aortic arch. The bend from the aorta, into the coronary ostium and thereafter through the coronary arteries are sharper and shorter radiused. The length of the more flexible distal segment 34 is sufficient so that the balloon can reach deeply into the coronary arterial tree without requiring the stiffer proximal tubing 28 to pass through relatively sharp bends, such as the bend from a guide catheter to the coronary ostium. The distal segment 34, which consists substantially of the thin, flexible support wire 44 is able to make the relatively sharp bends with ease. Thus, the only portion of the catheter 12 which actually enters the coronary artery is that which includes the slender support wire 44. This support wire is very flexible and is more easily bent to be able to negotiate shorter radius bends encountered in the coronary arterial tree. The catheter is highly steerable due in large measure to the solid wall of the tubing in the elongate proximal segment 28. The tubing is substantially torsionally rigid and tends to transmit substantially all of its rotation applied at the proximal end to the distal end. Although the intermediate segment of the catheter, which includes the slender 0.008 inch diameter wire is too small a diameter to effectively transmit torque over relatively long distances, the distal segment 34 is relatively short, preferably about 25 cm to 32 cm and, therefore, does not have too great of an adverse effect on the torque transmission from the proximal end of the catheter to the distal end. The distal segment preferably is no longer than about 25 cm to 32 cm, as compared to the solid wall tubular proximal segment which is approximately 143 cm to 150 cm long. Thus, by forming a bend in the distal tip 70 of the leading segment, the direction of the catheter 12 can be controlled by rotating the catheter from the proximal end. The helical coil 50 and the marker band 72 are formed from highly radiopaque material, such as platinum or an alloy containing a high percentage of platinum. The coil 50 and marker band 72 thus are useful to indicate the location of the leader segment 48 and the proximal end of the balloon under fluoroscopy. It is important when performing an angioplasty that the physician be aware of the configuration and shape of the patient's coronary arteries. Typically, that is achieved by infusing radiopaque contrast liquid into the patient's artery and observing the patient's arteries under fluoroscopy for the brief interval that the radiopaque contrast liquid is in the artery, usually a few seconds. The physician thus is not provided with continuous information as to the configuration of the artery through which the catheter is passed. It would be desirable for the physician to have such information. Thus, in order to provide a means by which the physician may continually observe the orientation of the catheter and the configuration of the coronary artery through which the catheter is passed, the present invention provides an elongate radiopaque element extending along most or all of the distal segment 34 of the catheter. In the illustrative embodiment, the means for rendering the distal segment 34 radiopaque under fluoroscopy preferably is achieved by plating the support wire 44 with a radiopaque material, such as gold indicated schematically at 45 in FIG. 5. The support wire 44 may be coated fully along its length, from its junction with the tubing 36 distally through the balloon. Alternately, the region of the support wire 44 that extends through the balloon 26 may remain unplated so as not to be observable under fluoroscopy. Thus, when the catheter is disposed in the patient's arteries, a substantial length of the catheter, proximally of the balloon will be fluoroscopically observable, thus providing the physician with an indication of the contour and path of the coronary artery without requiring the infusion of radiopaque contrast liquid. It is preferred that the radiopaque image provided along the length of the distal segment of the catheter is sufficiently dark so that it is observable under fluoroscopy but not so dark that it might interfere with the physician's more detailed observation of specific portions of the coronary anatomy by infusing radiopaque contrast liquid. Therefore, it is preferred that the means by which the distal segment 34 is rendered radiopaque is configured so that the fluoroscopic image that it creates is lighter than the darkest image achievable. Preferably, the degree of radiopacity is such as to present a "gray" image, as compared with the very dark image provided by the radiopaque coil 50 in the leader segment and the marker band 72. By providing a "gray" image, the physician is able to observe the path and orientation of the distal segment of the catheter 34 but without adversely obstructing the fluoroscopic image presented when radiopaque contrast liquid is infused into the artery. By way of example, the support wire 44 may be in the form of an inner core 44A plated with a layer 45 of gold of the order of 0.0002" to 0.0007" thick. The helical coil 50 is wound from a platinum alloy wire of the order of 0.003" in diameter. The marker band 72 may be formed from a platinum alloy ring. Thus, in the illustrative embodiment, the catheter would provide a fluoroscopic image in which the relatively short leader segment 48 and marker band 72 at the proximal end of the balloon 26 appear quite dark while the support wire 44 would appear as a lighter, gray image. It may be desirable to avoid any radiopaque means along the length of the balloon itself so that the region of the artery in which the balloon is located, namely, the critical region of the stenosis, can be observed completely and only with radiopaque contrast liquid without even minor fluoroscopic obstruction. That may be achieved simply by omitting the gold plating from that portion of the support wire 44 that extends through the balloon. As an alternative to plating the support wire 44 with a highly radiopaque material such as gold, the moderately radiopaque, "gray" distal segment 34 may be achieved by forming the wire 44 itself from a moderately radiopaque alloy. For example, alloys of platinum, gold and ruthenium may be employed, selected as to maintain adequate torsional riqidity for the distal segment 34 of the catheter. Yet another alternative for providing the moderately radiopaque segment is to make a support wire 44 from clad wire, as illustrated in enlarged and exaggerated cross sectional detail in FIG. 6. As shown in FIG. 6 a clad support wire 44 includes an inner core 44B about which is mechanically constricted a tubular cladding or jacket 74 of radiopaque material. The clad wire arrangement is preferable where it is desired to provide a thicker layer of radiopaque material about the inner core 44B. In contrast, conventional electroplating is a relatively time consuming procedure and the approximate maximum thickness to which gold plating may be made is of the order of 0.0005 inches. Considerably thicker layers may be achieved when using the clad wire. The clad wire is made by providing a core wire 44B and a thin wall tube of the metal from which the jacket 74 is to be made. By way of example, in order to make a support wire 0.008 inches in diameter the core wire 44B may be formed from stainless steel 0.003 inches in diameter. A length of gold hypodermic tubing, having a wall thickness in the order of 0.003 inches and an internal diameter just slightly greater than that of the inner core 44B, such as 0.0035 inches, is provided. The gold hypodermic tubing is slipped over the inner core 44B and together, they are drawn through a die having an outer diameter of 0.008 inches. The die constricts and draws the gold hypodermic tubing to a smaller diameter, tightly about the core wire 44B to secure them together mechanically into the composite wire. Similarly clad wire is available commercially from a number of commercial sources, such as the Sigmund Cohn Company in Mt. Vernon, N.Y. Of course, other materials and dimensions for the inner core 44B and jacket 74 may be selected, depending on the desired characteristics of the wire. By way of further example, the core wire 44B could be 0.006 inches in diameter with the cladding 74 having a final thickness in the order of 0.001 inches. Among the advantages of using clad wire for the support wire 44 is that by grinding away segments of the radiopaque cladding, as desired, the radiopacity along the length of the support wire 44 may be varied as desired. For example, if it is desired to make a catheter in which the portion of the distal segment proximally of the balloon has a moderate "gray" radiopacity while the portion under the balloon has no radiopacity, of the cladding 74 can be ground away in the region of the support wire that will be disposed of within the balloon. In such an embodiment, it also may be desirable to provide a highly radiopaque marker band on the support wire 44 or in the region of the proximal and distal end of the balloon so as to highlight the ends of the balloon fluoroscopically. FIG. 7 illustrates a further embodiment having a support wire with a step tapered configuration at its distal region as well as a clad configuration for the support wire. As shown in FIG. 7, the support wire 44 has a proximal portion 45 that is of a continuous diameter such as 0.008 inches for most of its length. The distal, approximately 8.5 centimeters of the support wire may be progressively tapered in a step tapered arrangement to provide for increasing flexibility in a distal direction. For example, the 0.008 inch diameter cylindrical support wire may include a tapering, conical segment 76, about 3 centimeters in length and tapering down to about 0.006 inches. The segment 76 then merges into a cylindrical barrel segment 78 of constant diameter (0.006 inches). The barrel segment 78 may be of the order of 2.5 centimeters in length. The distal most segment 80 may form a second conically tapered portion, tapering down to a distal tip approximately 0.002 inches in diameter. In this embodiment the proximal end of the coil spring may be attached to the segment 80 so that the proximal edge of the spring is approximately 1.8 centimeters from the distal tip of the segment 80. The balloon, which may be of the order of 2.5 centimeters long is attached adhesively at its distal end to the proximal end of the spring. The proximal end of the balloon is attached to the extension 60 in the region of the barrel segment 78. Such a core wire may be formed from nonradiopaque wire or from wire plated with a radiopaque metal or made from clad wire. In the plated configuration, the wire may be made with plated and unplated segments using conventional selected plating techniques relating to those in the plating art. Should it be preferred to use clad wire, a length of such clad wire may be provided and then its distal end may be centerless ground to provide the desired tapered configuration for the catheter. Depending on the final dimension, some or all of the cladding may be ground away at the distal region of the wire. For example, in the embodiment illustrated in FIG. 7, if the cladding were approximately 0.001 inches thick, the barrel segments 78, 80 would be free of cladding, the cladding having been ground away during the centerless grinding operation. The moderately radiopaque segment may have a proximal extremity about 35 cm from the distal tip of the wire 44, as suggested in phantom at 82 in FIG. 7. The support wire 44 is shown in exaggerated diameter, out of scale, for purpose of illustration. From the foregoing, it will be appreciated that the invention provides improvements to balloon dilatation catheters, particularly those used in coronary angioplasty, by providing a means by which the physician may be provided with a continuous fluoroscopic indication of the configuration of the coronary artery through which the catheter passes along a substantial distance along a proximal segment of the catheter. Moreover, that object is achieved without unduly obstructing the fluoroscopic image of the coronary anatomy when it is desired to infuse radiopaque contrast liquid. It should be understood, however, that the foregoing description of the invention is intended merely to be illustrative thereof and that other modifications, embodiments and equivalents of the invention will be apparent to those skilled in the art without departing from its spirit. Patent Citations
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| Havana by AramisThere is nothing like Havana. Spicy, warm yet invigorating, complex, refined, yet it has a bad-ass edge to it. There are so many facets to this fragrance. This cologne is not for the clean sweet and fruity or powdery-vanilla crowd. Havana is super masculine. The aroma is powerful and assertive, yet sophisticated and classy. 30th January, 2012 |
| PS by Paul SebastianJust tried this the other day (at Macy's) and had to buy it. Yet, I bought it at Marshalls because it was cheaper. What a perfectly balanced, soft but masculine oriental with very good longevity and sillage (needing only 1 spray). All these years I walked by it at the department stores thinking it was a cheap cologne for old men. Boy was I wrong. This one is such a winner. I see it being so versatile, except for maybe in extreme heat. I can't believe the quality of this juice ...and a mere $20 for a 4.0oz bottle. 30th November, 2011 (Last Edited: 17th December, 2011) |
| Halston Z-14 by HalstonI got rid of the new version of Z-14 recently because I wasn't impressed. It felt flat, plain cheap cinnamon aroma. I give it a 5 out of 10 overall. It ONLY had treemoss listed as the ingredients, NO OAKMOSS. 23rd November, 2011 |
| Jacomo for Men by JacomoJacomo for Men (Jacomo Silver) is a really unique spicy masculine scent, with notes of pimento, ginger, pepper,and a touch of dried plum and pineapple. As it wears on, you smell some vetiver and tonka bean and amber. Minimal sweetness makes it stand out from most of the current mass market designer these days. 22nd November, 2011 |
| Guess by Marciano for Men by GuessI am new to the fragrance game. I just got this and really enjoy it. I have colognes that I love and ones that women love (the only reason I wear those ones). But there's something about this cologne that makes me want to constantly smell myself. I see it as a cologne that anyone could appreciate being around. I bought this as a blind buy based on reviews from numerous sites. This works best as an evening or fall/winter scent but what do I know, I'm a rookie. Slightly reminds me of Obsession but softer and not "old man-ish" like Obsession smells to me. Paid $16 (shipped) for a 3.4oz tester, what a steal. 28th December, 2010 |
| Perry Ellis for Men (new) by Perry Ellis"Newer is Better" 23rd December, 2010 (Last Edited: 07th February, 2012) |
| 360 Degrees Black For Men by Perry EllisIf you like 360 White (a JPG La Male clone) you will love 360 Black because they are similar, but black has extra spices in it which makes it slightly more masculine and complex. Both are cold weather, romantic or evening colognes though so I don't feel it is fair to compare them to the original 360. 23rd December, 2010 (Last Edited: 26th December, 2011) |


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Photograph - Alcoa Austraila Exhibit, The Melbourne International Centenary Exhibition, Royal Exhibition Buildings, 1980 Reg. No: MM 124474
- Summary:
- Black & white photograph of Alcoa Australia's exhibit at the Melbourne International Centenary Exhibition held at the Royal Exhibition Buildings, Melbourne, between 23 September and 5 October 1980.
This is one of 959 photographs (or images) of the Exhibition Building collated by the Exhibition Trustees as a 10 volume pictorial history of the Exhibition Building spanning the years 1880 to 1985. The pictorial history was instigated by the centenary of the Exhibition Building in 1980 and forms part of a larger Royal Exhibition Building collection of documents, photographs, objects and research files. - Description:
- A black & white silver gelatin print on a page of a photograph album. There is a printed caption below the photograph.
- Description Of Content:
- Black & white photograph of the Alcoa Australia exhibit at the Melbourne International Centenary Exhibition held at the Royal Exhibition Buildings, Melbourne, between 23 September and 5 October 1980. The exhibit is constructed around the central form of a pyramid comprising diamond and trinangular panels, with Alcoa Australia signage displayed on the exterior panels. Numerous exhibition attendees can be seen at the base of the exhibit, while to the right on the Alcoa exhibit can be noted the French exhibit.
- Acquisition Information:
- Transfer from Trustees of the Royal Exhibition Building (REB), 2000
Discipline: | History |
Dimensions: | 191 mm (Height), 243 mm (Width) |
More information
Tagged with: | centenaries, royal exhibition building, royal exhibition building trustees, royal exhibition building centenary of opening, exhibitions melbourne international centenary 1980 |
Themes this item is part of: | Images & Image Making Collection, Public Life & Institutions Collection, Royal Exhibition Building Collection |
Primary Classification: | ROYAL EXHIBITION BUILDING |
Secondary Classification: | Commemorative Ceremonies |
Tertiary Classification: | exhibition building centenary 1980 |
Inscriptions: | EXHIBITION CENTENARY CELEBRATIONS/ THE MELBOURNE INTERNATIONAL CENTENARY EXHIBITION/ Alcoa Australia's Exhibit - Western Annexe. |
Format: | Photograph: Black & White |
Place & Date Depicted: | Royal Exhibition Building (REB), Melbourne, Victoria, Australia, 1980 |
This item is part of the following themes:


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Born: August 21
I own a jazz/blues club (Water's Edge Bar & Grill) in Slidell, LA and write for Downbeat magazine, the New Orleans Weekly Gambit, All About Jazz and other music related mags/zines. Play the drums (briefly studied with Andrew Cyrille) and trying to start a house band at the club. Did some freelance photography years back, i.e. Corporate Functions, landscapes, drunks. Also spent time in a rainforest in Indonesia.
I'm an Information Technology Consultant (Not too persistent, but pushy by nature.) Hence, results oriented. Resumes are available upon request. Was born in Da Bronx (a borough of The Big Apple) and feel a bit silly writing about myself at this moment...
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A selection of the 220 participants from the QuiltArt Network are presented in this ongoing, free-form exercise in creativity, specifically planned to encourage quilt artists to stretch and grow. Participation has grown to such proportions that the artists were requested to select their best quilt pages for exhibition. The exhibit consists of five small monthly quilt pages done over time and a journal entry from each participating artist.
Carol Ann Clasper
Scotland Marion Coleman
Castro Valley, California, USA Geraldine Congdon
Santa Rosa, California, USA
Anne Clough
Huntsville, Alabama, USA Jodi Colvard
Gainesville, Florida, USA Anne Copeland
Lomita, California, USA
Coralyn Colladay
Kensington, Maryland, USA Della Alice Cruz
Omaha, Nebraska, USA
Olof I. Davidsdottir
Reykjavik, Iceland
Lynne G. Croswell
Newton, Connecticut, USA Anne Datko
Wheaton, Maryland, USA Paula Dennee
Loveland, Colorado, USA


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Hi Everybody!
I have been tagged by IzzI!!!!!April 6th 2008 6:45 am[ Leave A Comment ]
Hi everybody!! I have been tagged by my friend Izzi! My task is to answer five questions with four answers, then tag four more furiends to do the same. Here we go!!! Leave a Comment |
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Browsing Recipes similiar to American Indian Sunflower Seed Cakes.
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Sunflower bread is so good; i had this in an Irish restaurant a couple of times and at Disney- Garden Grill RestaurantLand Pavilion - From Chef Mike...
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This is adapted from Crescent Dragonwagon's Cornbread Gospels. Dragonwagon cites Nelly Custis, Martha Washington's youngest granddaughter, gave an account...
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Flax Seed Raisin Bread in Bread Maker
This is one of the best flax seed breads I have ever tasted. The texture is really light and very moist. It is just the right sweetness and the sunflower...
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If you are searching for a spiritual home that is guided not by dogma or a set creed but by an open-minded quest for truth and meaning, welcome to the West Hills Unitarian Universalist Fellowship (WHUUF). We are a liberal religious community that encourages you to seek your own spiritual path wherever it leads, to nurture your spirit and put your faith into action by helping to make our communities and the world a better place.
At WHUUF we experience a vibrant and living tradition of music, worship, affirmation and transformation. This fellowship is a place where people, gathering from many walks of life, find a common denominator in our respect for the dignity and worth of each individual. Unitarian Universalism is based on:
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Released: Dec 01st, 1989
Running Time: 90
Director: J T Monroe
Company: Dreamland Elite
Tom Byron, Eric Boyer, Keisha (I), Victoria Paris, Eric Price, Randy West
Critical Rating: AAA 1/2
Genre: Feature
Similar to the plot of Seduction Of Lana Shore, only in reverse, Keisha plays an actress who does "Mary Poppins roles" but is dying to bury her image by taking it before the cameras. Randy West, as the hardboiled cocksucker who heads the studio that has her under contract, knows precisely where his bread gets buttered, and thus establishes the conflict and all the jockeying for position that will be explored in a sequel to this feature.
But for now, the first installment of Body Music explores the many interesting facets of Keisha's Rachel character –her relations to her agent Tom Byron, a lesbian love affair with friend Erica Boyer, and her self-examination and desire to grow up and become a real woman.
Whether the set design or colors were chose on purpose, they do suggest a certain industrial strength cold steel- gray that's symbolic of all the barriers people establish and those which Keisha must penetrate to satisfy her wants. Nifty little T & A moves are worked beautifully into the sex scenes; when was the last time you remember a camera allowed to dwell up and down a body and appreciate it for its aesthetic beauty? The Keisha/Erica Boyer love scene is by for one of the best girl-girl seduction scenarios you'll run across as it's sparkled with wit, small talk an utterly plausible concept, and sensitivity. Stunning in its rendition!
Body Music is a better-than-solid entry in the couples market… It's something you've simply got to share. Keisha looks nice on box cover.


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Jacqueline de Romilly
Jacqueline de Romilly | |
Born | Chartres, France |
26 March 1913
Died | 18 December 2010 Boulogne-Billancourt, France |
(aged 97)
Nationality | French |
Education | Lycée Louis-le-Grand |
Alma mater | École Normale Supérieure |
Occupation | Writer Teacher |
Known for | Member of the Académie française |
Jacqueline Worms de Romilly (French: [ʁɔmiji]; née David,[1] 26 March 1913 – 18 December 2010) was a Franco-Greek philologist, classical scholar and fiction writer. Because she was of Jewish ancestry, the Vichy government suspended her from her teaching duties during the Occupation of France.[2] she was the first woman nominated to the Collège de France, and in 1988, the second woman to enter the Académie française. She was also known for her work on the culture and language of ancient Greece, and in particular on Thucydides.
Born in Chartres, Eure-et-Loir, she studied at the Lycée Molière, where she won the Concours général in Latin and took second prize in Greek in 1930. She then prepared for the École Normale Supérieure at the Lycée Louis-le-Grand. She entered the class of 1933 of the ENS Ulm. She passed the agrégation in classics in 1936, and became a doctor of letters in 1947.
After being a schoolteacher, she became a professor at Lille University and subsequently at the Sorbonne, between 1957 and 1973. She later was promoted to the chair of Greek and the development of moral and political thought at the Collège de France — the first woman nominated to this prestigious institution. In 1988, she was the second woman (after Marguerite Yourcenar) to enter the Académie française, being elected to Chair #7, which was previously occupied by André Roussin.
In 1995, she obtained Greek nationality and in 2000 was named as an Ambassador of Hellenism by the Greek government. A one-time president of the Association Guillaume Budé, she remained an honorary president until her death at a hospital in Boulogne-Billancourt at the age of 97.[3]
After having only received baptism in 1940, she fully converted to Maronite Catholicism in 2008, aged 95.[4][5]
Honours and awards[edit]
- Grand Cross of the Legion of Honour (2007)
- Grand Cross of the Ordre national du Mérite
- Commander of the Ordre des Palmes Académiques
- Commander of the Ordre des Arts et des Lettres
- Commander of the Order of the Phoenix (Greece)
- Commander of the Order of Honour (Greece)
- Elected to the Académie française (24 November 24, 1988)
- First woman professor at the Collège de France (Chair: Greece and the formation of the moral and political thought)
- First woman member of the Académie des Inscriptions et Belles-Lettres (1975)
- President of the Academy of Inscriptions and Belles-Lettres (1987)
- Austrian Decoration for Science and Art (1981)[6]
- Appointed by Greece as Ambassador of Hellenism (which it receives citizenship in 1995)(2000)
- Ambatielos Prize of the Académie des Inscriptions et Belles-Lettres (1948)
- Croiset Prize of the Institut de France (1969)
- Langlois Prize of the Académie française (1974)
- Grand Prize of the Académie française (1984
- Onassis Prize (Athens, 1995)
- Daudet Prize for defence of the French language (2000)
- Prize of the Greek Parliament (2008)
- Foreign Honorary Member of the American Academy of Arts and Sciences (1988)[7]
- Corresponding member of foreign academies: Denmark, Great Britain, Vienna, Athens, Bavaria, the Netherlands, Naples, Turin, Genoa and the United States.
- Honorary doctorates from the universities of Oxford, Athens, Dublin, Heidelberg, Montreal and Yale University
- ^ "French Scholar Jacqueline de Romilly Dies at 97" Los Angeles Times 20 December 2010
- ^ "D'origine juive, elle est suspendue de ses fonctions par le régime de Vichy en 1941."
- ^ "Jacqueline de Romilly, helléniste et académicienne, est morte". Le Monde. Retrieved 19 December 2010.
- ^ "Dossier. Jacqueline de Romilly, une Athénienne au XXe siècle". La Croix. Retrieved 20 December 2010.
- ^ "Réaction du P. Mansour Labaky au décès de Jacqueline de Romilly". La Croix. Retrieved 20 December 2010.
- ^ "Reply to a parliamentary question" (PDF) (in German). p. 626. Retrieved 22 November 2012.
- ^ "Book of Members, 1780–2010: Chapter D" (PDF). American Academy of Arts and Sciences. Retrieved 25 July 2014.
External links[edit]
- L'Académie française (French)
- 1913 births
- 2010 deaths
- People from Chartres
- French Jews
- French Roman Catholics
- French Maronites
- Converts to Eastern Catholicism
- Collège de France faculty
- Lycée Louis-le-Grand alumni
- École Normale Supérieure alumni
- École Normale Supérieure faculty
- Members of the Académie française
- Members of the Académie des Inscriptions et Belles-Lettres
- Grand Croix of the Légion d'honneur
- Grand Croix of the Ordre national du Mérite
- Commandeurs of the Ordre des Palmes Académiques
- Commandeurs of the Ordre des Arts et des Lettres
- Commanders of the Order of the Phoenix (Greece)
- Commanders of the Order of Honour (Greece)
- Fellows of the American Academy of Arts and Sciences
- Recipients of the Austrian Decoration for Science and Art
- Historians of antiquity


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Findings aid understanding of neurodegenerative diseases
...n's, Alzheimer's and Lou Gehrig's diseases, cystic fibrosis and Creutzfeldt-Jakob disease, the human form of mad cow disease. The findings, which will be published in the Oct. 1 issue of Nature Cell Biology, could lead to an understanding of how to prevent these diseases and to the development of effective d...Cystic fibrosis gene mutations missing from some cases
...ins finds that some patients diagnosed with cystic fibrosis (CF) lack any of the more than 1,000 reported dise...FTR will improve diagnosis and treatment of cystic fibrosis and cystic fibrosis-like conditions." In the new study, of 74 patients diagnosed with non-classic CF...World-first gene therapy for cystic fibrosis targets lung stem cells?
The genetically inherited disease cystic fibrosis causes severe, unrelenting lung disease in childre...erapy in our lungs. "Using a mouse model of cystic fibrosis Maria Limberis, a PhD student in our lab, has helped us develop a system to briefly overcome these d...New screening technique may speed hunt for genes
...nvolved in a few inherited diseases such as cystic fibrosis have been identified, many have not. Now, two scientists say they may have found a way to make the search more economical and speed it up. In an article to appear online in the Proceedings of the National Academy of Sciences next week, scientists fr...JCI Table of Contents, November 18, 2002
...n activator gene in mice reducesrenal interstitial fibrosis in obstructive nephropathy CONTACT: Youhua Liu University of Pittsburgh School of Medicine Department of Pathology S-405 Biomedical Science Tower 200 Lothrop Street Pittsburgh, PA 15261 USA Phone 1: 412-648-8253 Fax 1: 412-648-1916 E-mail: liuy@msx...U.S.-German research consortium sequences genome of versatile soil microbe
...pathogen and the leading cause of death for cystic fibrosis patients. TIGR evolutionary biologist Jonathan Eisen said, "Such comparisons among closely related species with different biological properties are invaluable in learning about the biology of each species. In this case it allows us to better identify...JCI Table of Contents, December 2, 2002
... of waterfrom the circulation. In 1989 the cystic fibrosis gene was identified and found to encode achloride channel in cells lining the lung. Recognized as the cystic fibrosistransmembrane conductance regulator (CFTR), no compounds were known toinhibit the activity of this channel - until now. In the Decemb...Alternative treatment for secretory diarrhea linked to the cystic fibrosis gene
...f water from the circulation. In 1989 the cystic fibrosis gene was identified and found to encode a chloride...in cells lining the lung. Recognized as the cystic fibrosis transmembrane conductance regulator (CFTR), no compounds were known to inhibit the activity of this ...A new approach holds promise for reducing cocaine craving
... n-acetyl cysteine, which is used to treat cystic fibrosis and several other disorders reverses the changes in brain chemistry that appear to cause cocaine craving," said David A. Baker, a post-doctoral fellow in the laboratory of Peter W. Kalivas at the Medical University of South Carolina. Baker presented...Observing proteins and cells in the wild
...ical ones. For example, in such diseases as cystic fibrosis and Alzheimer's, certain proteins travel to the wrong places; like a milk truck delivering its goods to a post office instead of the grocery store, the aberrant proteins disrupt the working community of the cell. By using quantum dots to follow these...Purdue works to transform Ebola virus from killer to healer
... certain defective genes within lung cells. Cystic fibrosis and lung cancer are diseases that Sanders' group hopes to tackle. "Cystic fibrosis is the most common serious genetic disease among Caucasians in the world," Sanders said. "Lung cance...JCI table of contents, December 15, 2002
... ACCOMPANYING COMMENTARY:Unexpected news in renal fibrosis CONTACT: Juan A. Oliver Columbia University Department of Medicine 630 West 168 Street New York, NY 10032 USA Phone: 212-305-6938 Fax: 212-305-3475 E-mail: firstname.lastname@example.com View the PDF of this commentary at: https://www.the-jci.org/press/17399....Applied Biosystems announces SNPlex ultra high throughput genotyping system
... is also employed in the Celera Diagnostics cystic fibrosis test, which has become one of the leading tests for detection of mutations associated with this disease. The SNPlex TM system will operate on the same instrument platform widely used for sequencing and linkage mapping, and can be used with both cus...New drug lead fights bacteria that can be lethal by disrupting quorum sensing and biofilms
...ection that strikes -- and usually kills -- cystic fibrosis patients and many others whose immune systems are ...une systems are compromised. In addition to cystic fibrosis patients, whose lungs become clogged with the bacteria, it infects patients receiving chemotherapy, ...Univ of MD study on prevalence of celiac disease
... as Crohn's disease, ulcerative colitis and cystic fibrosis combined," says Alessio Fasano, M.D., the study's principal investigator and professor of pediatrics, medicine and physiology at the University of Maryland School of Medicine. Celiac disease is a digestive disorder that is triggered by the protein ...UI study discovers cells segregate molecules to control signaling
...y. Certain airway diseases such as asthma, cystic fibrosis and smoking-associated bronchitis are known to impair the airway barrier. The UI study suggests that under these disease conditions heregulin or other messenger molecules might not be well segregated from their receptors, and the receptors might be a...New proteomic techniques reveal workings of bacteria linked to cystic fibrosis
...aeruginosa establish itself in the lungs of cystic fibrosis patients. The researchers used a new technology to...nosa is so virulent that it will often kill cystic fibrosis patients. The highly sensitive quantitative proteomic analysis of a whole bacteria performed in this...Cystic fibrosis gene therapy trial results encouraging
...st-of-its-kind gene therapy trial involving cystic fibrosis (CF) patients and a new compacted DNA technology. The Phase I trial involving 12 patients was launched one year ago by University Hospitals of Cleveland (UHC), Case Western Reserve University (CWRU) School of Medicine, Children's Hospital of Denver, ...Borrowing from Ebola virus could aid cystic fibrosis gene therapy
...roblem with current efforts in developing a cystic fibrosis gene therapy is that delivering genes into airway ...The discovery has implications for treating cystic fibrosis and other lung conditions where the genes needed for healthy lung function are mutated or absent. "M...Scientists investigate several techniques to achieve successful gene therapy
...eveloped, the cancer, vascular diseases and cystic fibrosis markets are likely to be the first to reap financial benefits from gene therapy. "Once the first successful products are on the market, numerous others are sure to follow and investor enthusiasm will most likely equal that currently enjoyed by monocl...


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of our UK undergraduates were employed or in further study six months after completing their studies
Based on Destination of Leavers from Higher Education statistics for 2012-13
Student satisfaction at record high.
The University's overall student satisfaction level is 86% according to the National Student Survey 2014.
For decades we have been developing strong and enduring partnerships, from our nationally-recognised work with schools, established connections to the health and police services to our exciting cultural offer in Kent and Medway.
As one of the country's main providers of training, education and skills to the public services, our partners are critical to our work.
We are connecting up our own internal expertise across faculties – education, health, business, social and applied sciences and arts and humanities – to engage in innovative work with communities around us. We also have a forward-thinking Outreach Team which provides essential links with schools and colleges across Kent and Medway to promote access to higher education.
Increasingly we are developing partnerships further afield which are extending our reach to share our passion for education in partnership as driver for transformative and sustainable change.
As we move forward our ambitions centre around the desire to layer key partnerships to include a range of activities which broadly fall into the following categories:
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The sole benefit of the Israeli blockade of the Gaza strip has light-heartedly been said to be its containment of the H1N1 Swine Flu virus. Restrictions on movement in and out of this densely populated area as well as ever widening limitations on the import of much needed goods have meant that the virus has been kept at bay until now. Nevertheless, there has been growing fear that the emergence of just one case could trigger an epidemic when it inevitably finds its way in.
By Zulaikha Abdullah
Swine Flu Reaches Gaza
- 09 December 2009
- Zulaikha Abdullah
Israeli racism in theory and practice
- 23 November 2009
- Zulaikha Abdullah
Zulaikha Abdullah
Researcher / Editor, Middle East Monitor, London
In recent years, and particularly since the carnage wrought in its offensive on Gaza, Zionist Israel's discriminatory practices and treatment of Palestinians has become subject to increasing scrutiny and criticism by the international community, human rights and humanitarian organizations all reflecting a growing world-wide consensus and repulsion. Israel as a military occupation that implements racist policies against the non-Jewish populations both inside its borders and within the territories it occupies acts in flagrant breach of numerous UN resolutions and is condemned by various international conventions against racism. Yet, meaningful public debate of this pressing issue remains taboo and its very existence is generally ignored.


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But don't just take our word for it, see what people are saying on Trip Advisor:
'"A fantastic park" (Rookley Park)'
Lesley P
Reviewed: 12 April 2015
'"Excellent and extremely helpful staff" (St Helens Park)'
Dianne Y
Reviewed: 14 April 2014
'"Great holiday" (Rookley Park)'
Richard P
Reviewed: 09 April 2015
Forget Barbados, Mauritius or even the Seychelles, as we've got our own beautiful island to discover here in the UK...
We're offering you an Isle of Wight caravan break for up to 6 people for £79 or for up to 8 people for £89. Alternatively, get a cottage break for up to 6 people for £99 or for up to 8 people for just £109, saving you up to 56% off Island View Holidays' prices.
Based in a choice of two or three-bedroom caravans or cottages on the Isle of Wight, you're bound to have a fun-packed stay thanks to today's deal! You can get away from the stresses of daily life for three weekend nights (Friday-Monday) or four weekday nights (Monday-Friday) in a group of up to six or eight people. You'll stay at Rookley Country Park, set in 23 acres of parkland with a range of facilities plus the Quarterdeck Bar & Eaterie and Spinnakers Entertainment Lounge, or the tranquil St Helens Holiday Park (for caravan stays only) where self-catering and car-free zones leave you at complete freedom to enjoy your holiday, your way.
Accommodation-wise, the caravans at Rookley Park offer open-plan sophistication, perfect for relaxing with the family, whilst the caravans at St Helens Park offer classic country chic, both with all the necessary amenities including fully equipped kitchen and a family-sized lounge complete with a TV and DVD player. If you prefer a cottage stay, head to Wight Cottage or Carisbrooke Cottage at Rookley Park, each offering comfortable stays in tastefully decorated rooms. Whichever one you pick, you'll enjoy Wi-Fi access and a lovely outdoor patio, perfect for that morning coffee. Have fun!
The deal can also entitle you to a Wowcher Wallet Credit. Click here for more info.


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Ways to enjoy a welcome break
From meat stew to sponge cake, there are almost as many end-of-fast dishes as there are Jews. We identify some of the more exotic choices.
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Break your fast on healthy fruit
Fasting is straightforward and we all do it pretty much the same. The Torah is quite clear. Put your human cravings to one side and focus on trying to obtain the highest level of spirituality through prayer and forgiveness. Nil by mouth. No food and no water from dusk to the following dusk. Simple. Not a lot of room for variation.
How we end the fast varies enormously. Geography, age and family background all play their part. Sephardi and Ashkenazi Jews each have their own customs.
The majority do it the traditional Ashkenazi way, with cups of tea and honey cake and then a selection of herrings both pickled and shmaltz, fried fish and salads. Many families will have evolved their own customs beyond this. My own have added salmon, quiches, salads, jacket potatoes and fruit platters. Another family reports a tradition of tucking into cauliflower cheese - good solid English comfort food.
Sephardi Jews have a range of dishes, very often taken from their particular country of origin. An Egyptian friend breaks her fast with copious cups of black coffee and kahk - savoury rings of bread coated with sesame seeds or cumin seeds - cheese sambousaks (pastries) and a selection of salads, normally including aubergine.
Good old gefilte fish
Also popular is ful medames - a vegetarian dish made with brown lentils or beans, olive oil, lemon juice, garlic, chopped parsley. Her special tradition is to include humus and boiled egg as the topping.
Boiled potatoes with a lemon dressing are also part of the minhag, sometimes enhanced with rice. So the focus is on light but nutritious spreads of dishes to end a day of fasting.
Michelle Ramden, owner of Olive, the Persian restaurant in Finchley, north London, breaks the fast with challah, cheese, egg, jam and cakes. Other Persians - Jews from Iran - tend to go straight into dinner with rice, chorresht (meat stew often flavoured with saffron), and kebabs, and a special drink that they have only at this time of year, called faloodeh sib, made with shredded apple, rose water, mineral water and sugar.
Over in Sweden, the table is set out with jugs of water, wine, Coca Cola, vegetable soup and vanilla sponge cake with lots of icing sugar. Sliced challah is plated up to be served with cheese, pickles and other deli favourites.
Italian Jews often tuck into a three-course meat meal, generally starting with salads or soup followed by a chicken dish. Silvia Nacamulli's family always start with her beef and chicken broth (see the recipe on the facing page).
Chef Fabienne Viner-Luzzato grew up in Paris where, she says, the fast was broken with "a Turkish coffee with lots of sugar, accompanied by a liqueur, home-made lemonade and biscuits to dip in the drinks (see the recipe on the facing page), followed by chicken soup, chicken with olives and preserved lemons, couscous with spinach and white bean, and fruit". She jokes that they finish with "Gaviscon and paracetamol".
So, as with many Jewish food rituals, there is no clearly defined rule for that first all-important meal after the fast. It varies from one continent to another. Climate and the ingredients indigenous to the specific areas play a vital part in the different recipes families enjoy. One thing they all have in common though - no meal is more welcome.
Lord Bew: If we could bring peace to Ireland, why not Israel?
An Irish-born, left-leaning academic who is not Jewish is not most people's idea of a high-ranking Israel advocate.
California dreaming
Napa Valley winemakers Jodie and Jeff Morgan have written their first kosher cookbook
Simple lamb shepherd's pie
It's not really a pie at all, and it's typically made with lamb topped with a potato crust.
Smoked salmon caprese with endive
It's easy to prepare and lovely to behold.


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Tim Jobe Graduate Student University of California, San Diego Division of Biology |
Lab Affiliations: PI: Julian Schroeder, Biological Sciences Division Co-PI: Elizabeth Komives, Department of Chemistry and Biochemistry Education: 2000-2005 BS in Chemical Engineering, New Mexico State University 2005-2007 MS in Agronomy, New Mexico State University 2007-Present PhD in Biological Sciences, University of California, San Diego Research Interests: My current research focus is on understanding signaling pathways involved in metal(oid) metabolism in plants. In particular, I am interested in nonessential elements, such as cadmium and arsenic that are of concern to human health and are listed on the EPA Superfund's top 7 priority list of hazardous substances (see CERCLA). My work involves evaluating previously identified mutants that have a misregulated response to the heavy metal cadmium. To evaluate these mutants, I use both genomic and proteomic tools. This approach will help to identify novel regulatory networks that may aid in increasing plant heavy metal uptake for phytoremediation purposes, or in decreasing heavy metal uptake in agronomic plants to limit human exposure. Publicaions: Coming soon (I hope)!!! |
University of California, San Diego Division of Biological Sciences Muir Biology Building, MC 0116 9500 Gilman Drive La Jolla, CA 92093-0357 USA |
Contact Info |
Phone: 858.534.7432 E-mail: tjobe(at)ucsd(dot)edu |


text:
Home | Our People |
Submissions | Reviewers | Orders | Contact Us |
The Second Ganzfield Novel
by Kate Kaynak
"Love at Second Sight."
The other minders, sparks, and charms aren't the only threats facing the people of Ganzfield.
Things are more dangerous than they seem for G-positives, and not everyone will survive.
Does Maddie have what it takes?
See what happens next in the sequel to Minder.
978-1-937053-07-9 : Paperback
978-0-9845311-3-4 : e-book
This title will be re-released in January 2013.


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About Ateliers Jean Nouvel
Ateliers Jean Nouvel
Paris | Seit 1970
Ateliers Jean Nouvel
10 Cité d'Angoulême,
Telefon +33 1 49 23 83 83
Fax +33 1 43 14 81 10
Jean Nouvel has headed his own architectural practice since 1970. For his work he has won, among others, the Gold Medal of the French Academy of Architecture, the Royal Gold Medal of the Royal Institute of British Architects, the Aga Khan Prize for the Arab World Institute, honorary fellowships in the AIA, France's National Grand Prize for Architecture. In 2001, Italy's Borromini Prize for the Lucerne Culture and Congress Center and Japan's Praemium Imperial Career Prize and in 2005, the Wolf Prize, the Arnold W. Brunner Memorial Prize in architecture and the International Highrise Award for the Agbar tower in 2006, the Pritzker Prize in 2008.
Among Mr. Nouvel's principal completed buildings are the Arab World Institute in Paris, the Lyon Opera House, the Cartier Foundation in Paris, The Galeries Lafayette department store in Berlin, the Lucerne Culture and Congress Center, the Tours Conference Center, The Hotel in Lucerne, the Andel office building in Prague, the Nantes Justice Center, the Dentsu Tower in Tokyo, the technology center in Wismar, the museum of archaeology in Périgueux, the Agbar office tower in Barcelona, the extension to the Queen Sophia museum in Madrid, the Quai Branly Museum in Paris, the Guthrie Theater in Minneapolis, the Brembo's research and development centre, the Richemont Corporation headquarters in Geneva, the swimming pool of Les Bains des docks in Le Havre, the Symphonic House in Copenhagen, an apartment building 40 Mercer street in New York Soho, an apartment building in New York Chelsea, The Ferrari's factory in Maranello Modena, The Pavilion B in the Fiera di Genova, he was commission to design 10th Serpentine Gallery Pavillion, an office building in the City of London, a mixed use building in Vienna, …
Among the projects currently under study or construction at Ateliers Jean Nouvel are, The sea center museum in Le Havre, the city hall in Montpellier, an office tower in Doha Qatar, the Theater "Archipel" in Perpignan, two apartment buildings in Ibiza Spain, an hotel in Barcelona, the Louvre Museum in Abu Dhabi, the Philharmonic Hall in Paris, the Tour de Verre in New York, a mixed use high-rise building in Sydney, The Tour Signal in Paris la Défense, the National Qatar Museum, the Grand Paris with Jean Marie Duthilleul and Michel Cantal-Dupart, and he is also the architect manager of l'île Seguin.
ICFF 2015 Architonic Guide
Für die ICFF in New York vom 15. bis 19. May haben wir für Sie den bewährten Architonic Guide zusammengestellt. Wir führen Sie stil- und zielsicher durch den Messejungle.
Download Guide
an additional sales representative for Italy who is ready to take on an exciting challenge.


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Non Tenure Track Faculty Lecturer and Instructional Assistant Professor « Position Deleted on 5/16/2013 »
Institution: | Illinois State University |
Location: | Normal, IL |
Category: |
Posted: | 12/17/2012 |
Application Due: | 05/15/2013 |
Type: | Part-Time/Adjunct |
In anticipation of possible openings throughout the academic year and summer sessions, the Sociology and Anthropology
Department maintains a pool of qualified persons interested in part-time non-tenure-track Instructional Assistant Professor and Lecturer
teaching positions. Applications are accepted continuously for part-time, non-tenure-track positions and reviewed as vacancies become
available. There may not be an actual vacancy at the time you apply.
Position Responsibilities:
Candidates will be expected to effectively teach the required course, including grading of assignments and
examination. Regular office hours are required as is willingness to meet with students outside class. No departmental service is expected.
Required Qualifications:
Minimally a master's degree in either sociology or anthropology is required for upper division classes and
preferred for classes at all levels. A bachelor's degree and at least 18 graduate hours is the minimal requirement for 100 and 200 level
About the Department:
Sociology and anthropology provides active programs in both disciplines at the undergraduate level, with a wide
variety of courses offered every semester. The department prides itself on top-quality teaching and strong attention to our undergraduate
To assure full consideration, send a letter of application, resume including transcripts, and contact information for
three references to:
Dr. Fred H. Smith, Chair; Department of Sociology and Anthropology; Illinois State University; Campus Box 4660;
Normal, IL 61761. Telephone: (309) 438-8668,
Applications will be reviewed as vacancies become available.


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To all those in So Cal, the December BUBBAS brunch meeting is on saturday, the 4th, at 10:30AM at the Corral Cafe in Burbank, on Burbank Blvd 2 blocks east of Hollywood Way. Call me if you have any questions. Everyone is welcome
Stu Schaller
December BUBBAS meeting
Started by
, Dec 01 2004 17:47
2 replies to this topic


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Dodge Motorsports announced today that it is withdrawing from NASCAR competition at the end of the season.
Dodge, which re-entered NASCAR competition in 2001 after a long hiatus, is pulling out after its lone remaining Sprint Cup team, Penske Racing, decided to join Ford Racing and the Chrysler-owned brand was unable to put together a deal with a new team for 2013.
The withdrawal comes even after Dodge redesigned its car along with other manufacturers for the 2013 season. But Gilles held out some hope that Dodge might return at some point.
"We love motorsports," Gilles said. "We'll find a way to make this all work in the future."
A video statement from Gilles is below:


text:
TempZone > Easy Mat > Single ConductorSupport Page
Related Product Lines
You can narrow down your product line by selecting one of the related product lines below.
Single Conductor Documentation
Below you will find all documentation for the Single Conductor product line. Documents are grouped by categories. If you do not see what you are searching for or need further assistance, contact our 24/7 support team at (800) 875-5285.
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text:
Mary Catherine Cooke is studying sustainable agriculture at MU. This is her first year as an MU Vagina Monologues cast member.
I joined the MU Vagina Monologues when a former cast member invited me. Being new to Mizzou, I figured it might be a good opportunity for my awkward, introverted self to meet some new people. Semi-hesitantly, I went to the first meeting and was surprised at how comfortable and open the cast members were; so open, in fact, that they were actually yelling the word "vagina." The combination of shock and interest compelled me to continue on to auditions, and later rehearsals.
At our first rehearsal, we opened with an icebreaker, otherwise known as an introvert's worst nightmare, with each person answering the question, "What is your favorite name for your vagina?" Slowly, the question crept closer and closer towards me, until at last, I nervously answered in a shaky voice.
I've grown a lot since that first rehearsal and I've learned that The Vagina Monologues is about so much more than just performing or raising funds (although, don't get me wrong, its about those things too!). The Vagina Monologues is about creating safe spaces. It's about not being scared to say the word "vagina" in public. It's about being able to dress and look however I want. It's about breaking down the taboos of a patriarchal society. And ultimately it's about solidarity.
More than 100 cast members joined The Vagina Monologues this year, each of us with different needs, wants, passions, goals and inspirations. Although we were each brought to The Vagina Monologues for different and personal reasons, together we stand in solidarity to end gender violence and to give the vagina its passionate praise long overdue.
When I joined The Vagina Monologues, I had genuinely no idea what I was getting myself into. I have been shocked, sad, happy, scared and angry during my journey and have learned more about myself than I was ever willing to think possible. I cannot thank my advisors and fellow cast members enough for allowing me to laugh, cry and learn with you over these past few months. I am truly humbled to be apart of such a beautiful and dedicated community of women. Week after week, I never cease to be amazed or inspired by your passion.
While I've always considered myself a feminist, I had to no real reason for joining The Vagina Monologues before, other than to push myself outside of my comfort zone a little.
Now, I can proudly say that I dedicate my performance and my time to my friends, family, and fellow cast members that are survivors of sexual, domestic and mental abuse. I invite each of them to join the The Vagina Monologues cast in standing up for themselves and other survivors.
In doing so, I would also like to invite my cashier at the grocery store, the guy who sits behind me in my Plant Science class, my yoga instructor, and my boss because vaginas aren't only relevant to people who have them.
So if you're nervous about coming to the show, don't be. It takes courage to stand up for something most people choose to ignore. If you're in town this Saturday, February 15, join us in Jesse Hall at 7 p.m. as we stand in solidarity against gender violence.
And if you're a female-bodied MU student or employee who's inspired after seeing The Monologues to stand up and possibly step out of your comfort zone, please consider performing in the 2015 Vagina Monologues, because trust me, there's nothing quite like yelling, "VAGINA!" with 100 strangers to test your boundaries.
This story is part of a section of the Missourian called From Readers, which is dedicated to your voices and your stories. We hope you'll consider sharing. Here's how. Supervising editor is Joy Mayer.


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ESPN's double standard
posted at 10/23/2008 4:02 PM EDT
ESPN wouldn't run a story about Bret Favre selling out his old team because it was unsubstantiated even though there was plenty of proof then when there is no new news but everyone is covering it and making comments of ESPN's lack of covering it, they start to cover it. So ESPN then makes statements about the Patriots being displeased essentially pissed at Brady....without any evidance...hmmmmm..they've never done that before... Tom Jackson comments about the Patriots hating BB or what about going on with the story about the Taped walk through. Im I the only one sick of the double standard?? Whenever the Patriots fart ESPN tries to make them look bad.... -
ESPN's double standard
posted at 10/23/2008 4:35 PM EDT
I've stopped looking at any ESPN media since mid-year, last year. -
ESPN's double standard
posted at 10/23/2008 4:51 PM EDT
I no longer watch espn also but this what happens when you hire has beens and morons to do your reporting for you.
ESPN's double standard
posted at 10/23/2008 6:49 PM EDT
ESPN loves moronic sports commentators because what they are interested in is the lowest common denominator in their listeners. The more they can dumn down their listenets the more they can zombie them into their products and stupid sports controversies---which they repeat over ad nauseum in their promos. When i think ESPN i think Fox News---as opposed to Fox sports. -
ESPN's double standard
posted at 10/24/2008 5:16 AM EDT
I stopped listening to ESPN after Jackson mouthed off and said this team hates there coach. -
ESPN's double standard
posted at 10/24/2008 5:31 AM EDT
ESPN - Every Sport Premature News
They are the worst -
ESPN's double standard
posted at 10/24/2008 5:50 AM EDT
Many of us don't watch ESPN or go to ESPN.com after they proliferated the hatred and lies toward and about the Patriot team, players and organization or all of last year through the offseason.
In case anyone forgets, Mark Schlerath, Mike Wilbon, and Steve Young all called for "old school retaliation (injury)" against Tom Brady in retaliation for succuss. Mark Schlerath and Chris Carter went on a live, three hour unapologetic lying spree on how the Patriots cheated in-game, using video fro the sidelines. They still have yet to apologize for allowing that anoying ret*rd Tony Kornholio to be allowed into any professional broadcast booth.
Unsubstantiated rumor and lies, proliferation of untruths and sensationalization of rule infractions or personal grudges is what ESPN does best.
Years ago, when they built their empire on sports coverage, ESPN was a good thing. Now, with the focus on TMZ inspired sensationalization, ESPN is a freak show of talentless (and often alien looking) talking heads in a cesspool of bias. -
ESPN's double standard
posted at 10/24/2008 5:54 AM EDT
Homer Simpson says, "Mmmmmm, "Cesspool of bias" ulllggghh." -
ESPN's double standard
posted at 10/24/2008 6:29 AM EDT
[Quote]I stopped listening to ESPN after Jackson mouthed off and said this team hates there coach.[/Quote]
Except for a game on ESPN and the Sports Reporters on Sunday morning, turning to ESPN is off my radar. -
ESPN's double standard
posted at 10/24/2008 6:52 AM EDT
Now I just follow the Pats news on Boston.com or check out rotoworld.com. -
ESPN's double standard
posted at 10/24/2008 7:07 AM EDT
[Quote]Homer Simpson says, "Mmmmmm, "Cesspool of bias" ulllggghh."[/Quote]Unfortunately journalism has suffered terribly during the past 20 years and previously, moreso during the last 20. They change a word, delete a few, add a few to make the report fit their agenda. I absolutely do not trust the mainline media at all. None!! Rarely do I watch tv news reports or read a mainstream newspaper because you do not know if the report is truth or fiction. -
ESPN's double standard
posted at 10/24/2008 7:33 AM EDT
I couldn't agree more sonieboy. As an English major linguistics/Philosophy minor, I find it unbelievable that Mainstream Media cannot just report THE Facts. At best Media is a sellout to sensationalism and sponsors within the theatre of entertainment, at worst, sonieboy, You are absolutely correct in assessing that there trully IS an agenda at play, and therefore Media becomes a director for whatever and whomever their executives/the writer/or those special interests groups (see United States Senators and Special Interests groups), as curtain boys to these cheap actors, deem are newsworthy or worthy at all. You are very perceptive, unlike the mass of men, in noting how 1 word, 1 sentence, 1 simple seemingly unnotable Fact that's either put in or left out, of a story.article/broadcast, skews whatever the person/network/etc. is trying to convey towards an opinion, subjectivity, a point...a prejudice or inclination , no matter how slight, that as being portrayed as fact, completely prohibits and skews what should have been ideally impartial judgement. The result is obvious, The person reading the article, watching the news, spaced from work, beat up by the kids, the boss, and making dinner, many time's unconciously becomes, to use a terribly elicit term, brainwashed. Sonieboy, I'd rather watch the Simpson's and Family Guy, and have my opinions, in the form of explicit satire, spoonfeed to me... At least I know what I'm eating, or that I even AM eating (I know, I know that last sentence was terrible, but as they say, "Good Poets use Bad Puns). -
ESPN's double standard
posted at 10/24/2008 9:58 AM EDT
ESPN-Sports Tabloid.
All New England fans have/will avoid ESPN at all costs. -
ESPN's double standard
posted at 10/24/2008 10:54 AM EDT
I'm wondering how all of this information was supposedly so readily available.........isn't there supposed to be confidentiality. I believe Tom Brady is the only person who is allowed to give out any medical details about himself (or must sign a waiver allowing his doctors to give out details) and I'm pretty sure he isn't leaking anything.
If ESPN can't get the news legitimately, do they just make it up? -
ESPN's double standard
posted at 10/24/2008 10:57 AM EDT
And, SeanGar-2, good writers don't take a thought or opinion and turn it into a diatribe . . .
You have mastered the art filling your writing with useless words.
Good God. People like you scare young kids away from reading.
The sad thing is homeless... that your writing has NONE of these problems. BTW Don't forget homeless that I intersperse my learned prose with Homer Simpson quotes, meaningless $5 facts, insane predictions that the world is going to end, cheap archetypes, expensive metaphors, and delusions of grandeur. -
ESPN's double standard
posted at 10/24/2008 11:01 AM EDT
I watch Wendy Nix -
ESPN's double standard
posted at 10/24/2008 11:32 AM EDT
ESPN broadcasts out of New York, many of its employees live and grew up in New York rooting for NY teams and therefore its bias is very anti-Boston; particularly lately when so many Boston teams have been dominant. Hell of a way to run a sports journalism channel. More like Fox News or MSNBC (take your pick). -
ESPN's double standard
posted at 10/24/2008 11:37 AM EDT
I gave up ESPN for Fox a long time ago. I can't really stand ESPN.


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"In a futuristic world, a strict regime has eliminated war by suppressing emotions: books, art and music are strictly forbidden and feeling is a crime punishable by death. Cleric John Preston is a top ranking government agent responsible for destroying those who resist the rules. When he misses a dose of Prozium, a mind-altering drug that hinders emotion, Preston, who has been trained to enforce the strict laws of the new regime, suddenly becomes the only person capable of overthrowing it" The modification is loosely based on the movie "Equilibrium" with the main focus of the work being based upon implementing a new combat system similar to the "gun kata" seen in some of the action scenes of the movie. The "Gun Kata" allows the player to take on several adversaries at the same time with dual weapons and gun them down in unison, much like what we see in the action movies of today where the hero wields dual handguns and shoots at different targets...
Dec 8th, 2014 0 people agree 0 people don't
Another great "mod" from one of the best "mods", what i know! It is really having, it's details, from original movie "Equilibrium!..
Aug 2nd, 2013 0 people agree 0 people don't
This mod is pretty good. The models are well done, the level in the HoM story is quite good. However, the two bosses as the end take forever to kill, and so do the enemies outside. They take far too many bullets, and so does the player. By simply going into gunkata mode, if you're patient, you can never take a bullet. However, this suffers from the same problem other gunkata mods do. It is ******* impossible to hit anything.
Oct 28th, 2012 0 people agree 0 people don't
Simply wonderful, a big fan of the movie as well as the game it self. And I just fell in love with the work of developers, the details truly wakes up some sweet emotions :)


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text:
Sangaranarayanan, MV and Rangarajan, SK (1983) An E-Convergence Method For The Evaluation Of Critical Parameters. In: Chemical Physics Letters, 101 (1). pp. 49-54.
art.pdf - Published Version Restricted to Registered users only Download (485Kb) | Request a copy |
Official URL: http://www.sciencedirect.com/science?_ob=MImg&_ima...
A simple cconversence technique is applied to obtain accurate estimates of critical temperatures and critical it\ponmts of a few two- and threpdiniensional king models. When applied to the virial series for hard spheres and hard discs, this method predicts a divergence of the equation-of-state at the density of closest packing.
Item Type: | Journal Article |
Additional Information: | Copyright of this article belongs to EIsevier Science. |
Department/Centre: | Division of Chemical Sciences > Inorganic & Physical Chemistry |
Date Deposited: | 02 Jun 2009 06:21 |
Last Modified: | 19 Sep 2010 05:32 |
URI: | http://eprints.iisc.ernet.in/id/eprint/20322 |
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Can't type apostrophe in Livestream Chat
I cannot type an apostrophe in Livestream chat. Every time I try to, I get this symbol instead: Þ. I also get a À when I try to type anything from the key to the left of the number 1 (tilde ~ or Grave Accent ').
I've reinstalled both Java and Flash, I've checked and even changed my keyboard settings, but the problem is persisting. I've also tried to replicate the issue elsewhere, but it is unique to Livestream chat. I've tried typing in other Java and Flash applications (as well as other programs on my computer), and it doesn't happen. My Browser is Chrome 28.0.1550.1 on Windows 7, and my standard keyboard setting is US-International (though I've tried changing that and it doesn't help). Does anybody know what is going on and how to fix it? It's extremely frustrating since the apostrophe is a very commonly used punctuation mark and it's important for distinguishing between many words. Other people seem to Last edited by fractal_fire; 18th August 2013 at 23:42. Reason: fixed typo |
Hello, I am unable to replicate the issue you are facing. I was able to use Apostrophe in the livestream chat. I would request you to create a ticket via the support center to troubleshoot this issue further. You can use this link: https://secure.livestream.com/myacco...center/tickets Regards, Ashok Producer Support |
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apostrophe, chat, keyboard, punctuation, type |
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Working on uploading recordings from my Sony M-10, sorry to keep repeating that. From a nearby train works factory, the sound of heavy metal objects being dropped into metal containers/skips/dumpsters.
awesome. perfect as a base for massive explosions.
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