text:
Richard Rogers
The Lord Rogers of Riverside | |
Rogers (left) with Queen Elizabeth II and Sue Essex AM (right), at the opening of the Senedd building in Cardiff, Wales.
Born | Richard George Rogers 23 July 1933 Florence, Italy |
Nationality | British, Italian |
Alma mater | Architectural Association School of Architecture, Yale School of Architecture |
Occupation | Architect |
Awards | RIBA Gold Medal (1985) Thomas Jefferson Medal (1999) Praemium Imperiale (2000) Stirling Prize (2006), (2009) Minerva Medal (2007) Pritzker Prize (2007) HonFREng[1] (2005) |
Practice | Rogers Stirk Harbour + Partners |
Buildings | Centre Georges Pompidou Lloyd's building (Grade I) Millennium Dome European Court of Human Rights Madrid-Barajas Airport terminal 4 London Heathrow Terminal 5 Senedd, Cardiff |
Projects | Towards an Urban Renaissance Grand Paris |
Richard George Rogers, Baron Rogers of Riverside, CH, FRIBA, FCSD, HonFREng[2] (born 23 July 1933) is an Italian-born British architect noted for his modernist and functionalist designs in high-tech architecture.
Rogers is perhaps best known for his work on the Pompidou Centre in Paris, the Lloyd's building and Millennium Dome both in London, the Senedd in Cardiff, and the European Court of Human Rights building in Strasbourg. He is a winner of the RIBA Gold Medal, the Thomas Jefferson Medal, the RIBA Stirling Prize, the Minerva Medal and Pritzker Prize.
Early life and career[edit]
Richard Rogers was born in Florence (Tuscany) in 1933 from Italian parents. His father, William Nino Rogers (1906-1993), was the cousin of Italian architect Ernesto Nathan Rogers. His ancestors moved from Sunderland to Venice in about 1800, then settling in Trieste, Milan and Florence. During World War II William Nino Rogers decided to come back to England. Richard went to St Johns School, Leatherhead upon moving to England, and later attended the Architectural Association School of Architecture in London, before graduating with a master's degree from the Yale School of Architecture in 1962.[3] While studying at Yale, Rogers met fellow architecture student Norman Foster and planning student Su Brumwell. On returning to England he, Foster and Brumwell set up architectural practice as Team 4 with Wendy Cheeseman (Brumwell later married Rogers, Cheeseman married Foster).[4] Rogers and Foster earned a reputation for what was later termed by the media high-tech architecture.[5]
By 1967, Team 4 had split up, but Rogers continued to collaborate with Su Rogers, along with John Young and Laurie Abbott.[6] In early 1968 he was commissioned to design a house and studio for Humphrey Spender near Maldon, Essex, a glass cube framed with I-beams. He continued to develop his ideas of prefabrication and structural simplicity to design a Wimbledon house for his parents. This was based on ideas from his conceptual 'Zip Up' house,[7] such as the use of standardized components based on refrigerator panels to make energy-efficient buildings. Rogers subsequently joined forces with Italian architect Renzo Piano, a partnership that was to prove fruitful. His career leapt forward when he, Piano and Gianfranco Franchini won the design competition for the Pompidou Centre in July 1971, alongside a team from Ove Arup that included Irish engineer Peter Rice.[8]
This building established Rogers's trademark of exposing most of the building's services (water, heating and ventilation ducts, and stairs) on the exterior, leaving the internal spaces uncluttered and open for visitors to the centre's art exhibitions. This style, dubbed "Bowellism" by some critics, was not universally popular at the time the centre opened in 1977, but today the Pompidou Centre is a widely admired Parisian landmark. Rogers revisited this inside-out style with his design for London's Lloyd's building, completed in 1986 – another controversial design which has since become a famous and distinctive landmark in its own right.
Later career[edit]
After working with Piano, Rogers established the Richard Rogers Partnership along with Marco Goldschmied, Mike Davies and John Young in 1977.[9] This became Rogers Stirk Harbour + Partners in 2007. The firm maintains offices in London, Shanghai and Sydney.
Rogers has devoted much of his later career to wider issues surrounding architecture, urbanism, sustainability and the ways in which cities are used. One early illustration of his thinking was an exhibition at the Royal Academy in 1986, entitled "London As It Could Be", which also featured the work of James Stirling and Rogers' former partner Norman Foster. This exhibition made public a series of proposals for transforming a large area of central London, subsequently dismissed as impractical by the city's authorities.
In 1995, he became the first architect to deliver the BBC's annual Reith Lectures. This series of five talks, titled Sustainable City, were later adapted into the book Cities for a Small Planet (Faber and Faber: London 1997, ISBN 0-571-17993-2). The BBC made these lectures available to the public for download in July 2011.[10]
In 1998, he set up the Urban Task Force at the invitation of the British government, to help identify causes of urban decline and establish a vision of safety, vitality and beauty for Britain's cities. This work resulted in a white paper, Towards an Urban Renaissance, outlining more than 100 recommendations for future city designers. Rogers also served for several years as chair of the Greater London Authority panel for Architecture and Urbanism. He has been chair of the board of Trustees of The Architecture Foundation. From 2001 to 2008 he was chief advisor on architecture and urbanism to Mayor of London Ken Livingstone; he was subsequently asked to continue his role as an advisor by new mayor Boris Johnson in 2008. He stood down from the post in October 2009.[11] Rogers has also served as an advisor to two mayors of Barcelona on urban strategies.
Amidst this extra-curricular activity, Rogers has continued to create controversial and iconic works. Perhaps the most famous of these, the Millennium Dome, was designed by the Rogers practice in conjunction with engineering firm Buro Happold and completed in 1999. It was the subject of fierce political and public debate over the cost and contents of the exhibition it contained; the building itself cost £43 million.[12]
In May 2006, Rogers' practice was chosen as the architect of Tower 3 of the new World Trade Center in New York City, replacing the old World Trade Center which was destroyed in the September 11 attacks.
Some of Rogers's recent plans have failed to get off the ground. The practice was appointed to design the replacement to the Central Library in the Eastside of Birmingham; however, his plan was shelved for financial reasons. City Park Gate, the area adjacent to the land the library would have stood on, is now being designed by Ken Shuttleworth's MAKE Architects.
Selected projects[edit]
Team 4[edit]
Richard and Su Rogers, with John Young and Laurie Abbott[edit]
- 22 Parkside (Dr. Nino and Dada Rogers' house), Wimbledon, London, UK (1967)[13]
- Zip Up house (1968)
- Humphrey Spender's house, Maldon, UK (1967–1968)
Piano + Rogers[edit]
- Universal Oil Products, Tadworth, UK (1969–1974)
- B&B Italia headquarters, Como, Italy (1972–1973)[14]
- Pompidou Centre, Paris, France (1971–77)
- IRCAM, Paris, France (1971–1977)
- Patscentre Research Laboratory, Melbourn, UK (1976–1983)
The Richard Rogers Partnership[edit]
Rogers Stirk Harbour + Partners[edit]
- London Heathrow Terminal 5, London, UK (1989–2008)
- Maggie's Centre, London, UK (2001–2008)
- Central Park Station (R9), Kaohsiung Mass Rapid Transit system, Kaohsiung City, Taiwan (2003–2007)
- 175 Greenwich Street, New York City (2006–)
- British Museum, World Conservation and Exhibitions Centre, London, UK (2007–2014)
- One Hyde Park, London (2007–2010)
- 122 Leadenhall Street (The Cheesegrater), London, UK (2009-2014)
- International Towers Sydney, Sydney (2009–)
Rogers has written several books during his career including:
- Architecture: A Modern View, Thames and Hudson (1991) ISBN 9780500276518
- A New London (co-author Mark Fisher and the Labour Party), Penguin (1992) ISBN 9780140157949
- Cities for a Small Planet, Faber & Faber (1997) ISBN 9780571179930
- Towards an Urban Renaissance, Urban Task Force (1999) ISBN 185112165X
- Cities for a Small Country, Faber & Faber (2000) ISBN 9780571206520
Honours and awards[edit]
Rogers was knighted in 1991 by Queen Elizabeth II.[16][17] He was created Baron Rogers of Riverside, of Chelsea in the Royal Borough of Kensington and Chelsea on 17 October 1996.[18] He sits as a Labour peer in the House of Lords.[19] Rogers was appointed a Member of the Order of the Companions of Honour (CH) in the 2008 Birthday Honours list.[20]
Rogers was awarded the RIBA Royal Gold Medal in 1985 and made a Chevalier, L'Ordre National de la Légion d'honneur in 1986. He received a Golden Lion for Lifetime Achievement at the 10th Mostra di Architettura di Venezia.[21] In 2006, the Richard Rogers Partnership was awarded the Stirling Prize for Terminal 4 of Barajas Airport,[22] and again in 2009 for Maggie's Centre in London.[23] He was also appointed as a Honorary Fellow[24] of the Royal Academy of Engineering[25] in 2005. In 2007 Rogers was made Laureate of the Pritzker Architecture Prize – architecture's highest honour.[26] He was awarded the Minerva Medal by the Chartered Society of Designers in the same year.
Rogers has been awarded honorary degrees from several universities, including Alfonso X El Sabio University in Madrid, Oxford Brookes University, the University of Kent, the Czech Technical University in Prague and the Open University. In 1994, he was awarded an Honorary Degree (Doctor of Science) by the University of Bath.[27]
Palestine controversy[edit]
In February 2006, Lord Rogers hosted the inaugural meeting of the campaigning organisation Architects and Planners for Justice in Palestine (APJP) in his London offices. At that time his practice had secured a number of projects in New York, including the redevelopment of the Silvercup Studios site, a masterplan for the East River Waterfront and a commission for a $1.7 billion expansion of the Jacob K. Javits Convention Centre in Manhattan. Rogers however publicly dissociated himself from the group within weeks, following an outcry from generally pro-Israeli New York voters and politicians, which threatened him with the loss of prestigious commissions including projects in New York and abroad.[28] He announced his withdrawal with the statement, "I unequivocally renounce Architects and Planners for Justice in Palestine and have withdrawn my relationship with them."[29]
Personal life[edit]
Rogers is married to Ruth Rogers, chef and co-owner of The River Café restaurant in west London. They have two sons together, Roo and Bo (deceased 2011).[30]
Rogers also has three sons, Ben, Zad and Ab, from his first marriage to Su Brumwell. He has ten grandchildren and a younger brother, Peter William Rogers, a property developer and co-founder of Stanhope.
In 2015, he was named one of GQ's 50 best dressed British men. [31]
- ^ "List of Fellows".
- ^ "List of Fellows".
- ^ "Richard Rogers". Press Release CV. Richard Rogers Partnerships. Retrieved 31 July 2006.
- ^ Ian Lambot (Ed.), "Norman Foster: Buildings and Projects Volume 1 1964–1973", Watermark Publications (1991), pp. 14–15, ISBN 1-873200-01-3.
- ^ "Richard Rogers + Architects – From the House to the City". Design Museum. Retrieved 4 February 2014.
- ^ "Richard Rogers, Pritzker Speech" (PDF). Rogers Stirk Harbour + Partners. Retrieved 11 July 2010.
- ^ "Richard Rogers: Beginnings". Pompidou Centre. Retrieved 23 October 2009.
- ^ "Architecture of the Building". Centre Pompidou website. Retrieved 3 July 2012.
- ^ "Competitively speaking: a born organiser, Marco Goldschmied of Richard Rogers Partnership is being tipped as a possible future RIBA president". Advameg Inc. Retrieved 11 July 2010.
- ^ "BBC Radio 4 unveils 60 years of Reith Lectures archive". BBC News. 26 June 2011.
- ^ "Richard Rogers steps down as advisor to mayor". Mayor of London's office. Retrieved 1 November 2009.
- ^ "Millennium Dome". RHSP. Retrieved 30 October 2009.
- ^ "Dr Rogers House". Richard Rogers Partnership. Retrieved 27 October 2006.
- ^ "B&B Italia.". Retrieved 22 October 2009.
- ^ "INMOS Factory – Richard Rogers". Retrieved 19 April 2009.
- ^ The London Gazette: (Supplement) no. 52563. p. 2. 15 June 1991.
- ^ The London Gazette: no. 52858. p. 4257. 10 March 1992.
- ^ The London Gazette: no. 54559. p. 14045. 23 October 1996.
- ^ UK Parliament. Parliament.uk
- ^ The London Gazette: (Supplement) no. 58729. p. 4. 14 June 2008.
- ^ Biennale Architecture: 10th International Architecture Exhibition (2006), Official Awards
- ^ "RIBA Stirling Prize 2006". RIBA. Retrieved 27 October 2006.
- ^ "RIBA Stirling Prize 2009". RIBA. Retrieved 26 November 2009.
- ^ "List of Fellows".
- ^ "List of Fellows".
- ^ Robin Pogrebin (28 March 2007). "British Architect Wins 2007 Pritzker Prize". New York Times. Retrieved 28 March 2007.
- ^ "Honorary Graduates 1989 to present". bath.ac.uk. University of Bath. Retrieved 18 February 2012.
- ^ "Boiling point". The Guardian (London). 9 March 2006. Retrieved 22 May 2010.
- ^ Burkeman, Oliver (9 March 2006). "Israel-Palestine conflict engulfs Rogers's .7bn New York project". The Guardian (London). Retrieved 22 May 2010.
- ^ Rainey, Sarah (3 November 2011). "Lord Rogers' son Bo found dead in bath". The Daily Telegraph (London).
- ^ "50 Best Dressed Men in Britain 2015". GQ. 5 Jan 2015.
External links[edit]
Wikimedia Commons has media related to Richard Rogers. |
- Rogers Stirk Harbour + Partners website
- Large list of major Richard Rogers skyscrapers with data and images
- Rogers, Stirk, Harbour and Partners projects portfolio
- Pritzker Prize 2007
- Richard Rogers presents the 2007 Annual Discourse at the Royal Institute of British Architects (video)
- The 1995 BBC Reith Lectures: Sustainable City by Richard Rogers
- Richard Rogers
- Richard Rogers buildings
- 1933 births
- British architects
- Labour Party (UK) life peers
- Members of the Order of the Companions of Honour
- Knights Bachelor
- Living people
- Modernist architects
- People educated at St John's School, Leatherhead
- People from Florence
- Fellows of the Royal Institute of British Architects
- Pritzker Architecture Prize winners
- Stirling Prize laureates
- Recipients of the Royal Gold Medal
- Recipients of the Praemium Imperiale
- People educated at Kingswood House School
- Italian architects
- Welsh Eisteddfod Gold Medal winners
- Yale School of Architecture alumni


text:
That's how the puppetmasters at Disney, those experts at the deceptively squishy hard sell, like it. Repetition is the key to kids' entertainment, and the live actors onstage in this show mimic, almost gesture for gesture, the movements of their animated counterparts. How humiliating that must be, even backed up by a fat road-tour paycheck.
In a Disney product, if it works once, do it again and then bring it back later as a reminder. In Disney's politically correct musical fairy tales, characters make the same jokes a jillion times, and the big songs repeat more often than a garlic sandwich. In Disney's Beauty and the Beast, there are no fewer than six repeats of various tunes throughout the show, four doubling up in the first act alone. This musical has more gratuitous reprises than Carol Channing's career.
At more than two and a half hours (90 minutes just for the first act), this show also goes long for big-budget children's theater (and that is, after all, all it is). The first half of Act 2 grinds away slowly with too much blather among the feather duster, Babette (Tracy Generalovich), Lumiere, the talking candelabrum (Rob Lorey), and Madame de la Grande Bouche (Monica M. Wemitt), who is some sort of laundry hamper or stereo cabinet.
The enchanted castle bursts the seams with talking furniture and dancing cutlery in Disney's Beauty and the Beast. A witch's curse has brought the pantry contents to life and turned a handsome prince (Roger Befeler) into a hairy troglodyte. The only hope for the cursed utensils is for a pretty girl to fall in love with the Beast, which will restore the furnishings back to human form. Meanwhile, until Belle (Jennifer Shrader) can be coaxed to love Beast, the salt cellars, sugar bowls, teapots and flyswatters remain imprisoned in a sort of Bed, Bath & Beyond set to music.
Beyond that, there's not much to this silly show. They pretend there's a message about inner beauty and true love and how a smart woman can change a troubled man into a prince, but we all know that's a crock (hey, where was the dancing crock?). Some good stage effects and sparkly fireworks wake up the tykes after the slow parts. Huge pieces of scenery slide around with cinematic speed, and at the end, when the Beast turns back into a pretty boy, they spin him like a whirligig midair. That's pretty cool.
But great music? No. Great acting? Dancing? No. No. Pity these actors a little for spending months on end dressed up as blenders and butter knives. For this they went to Juilliard. On the night reviewed, there was an announcement made that the role of the Doormat was being played by an understudy. Being the understudy for the role of the Doormat in a Disney musical serves as the very definition of "doormat." Some dreams die hard.

subset: commoncrawl


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text:
Lock Mfg. Company
Company Details:
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Phone: 951-638-3543
http://www.padlockinventor.com, http://www.securityanchor.com
Patent # 8,640,507 Horizontal Shackle For Lock System And Method. See last box below on left.
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Patent # 8,720,097 Trigger Lock.
Patent # 8,726,703 Low Profile Lock Interface System and Method.
June 5, 2014 Continuation-in-Part(C-I-P) Notice of Allowance(N-O-A) Apparatus For Securing a Portable Electronic Device.
Patent # 8,783,073 Apparatus For Securing A Portable Electronic Device.
September 8, 2014 Cinch Lock Apparatus and Method notice of allowance to issue very soon.
Majority of above allow portable electronic devices(laptops, tablets and smartphones) having a security slot/nub or not to be locked using your Clicksafe or Microsaver computer cable lock.
IP rights available.


text:
Summary: Shwachman-Bodian-Diamond syndrome (SBDS) protein
Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.
This is the Wikipedia entry entitled "SBDS". More...
SBDS Edit Wikipedia article
Ribosome maturation protein SBDS is a protein that in humans is encoded by the SBDS gene.[2] An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.[3] This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants.
The encoded protein may function in RNA metabolism.[3] The precise function of the SBDS protein is not known but it appears to play an important role in ribosome function or assembly.[4] Knockdown of SBDS expression results in increased apoptosis in erythroid cells undergoing differentiation due to elevated ROS levels. Hence SBDS is critical for normal erythropoiesis.[5]
This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. Members of this family play a role in RNA metabolism.[2][6]
A number of uncharacterised hydrophilic proteins of about 30 kDa share regions of similarity. These include,
- Mouse protein 22A3.
- Saccharomyces cerevisiae chromosome XII hypothetical protein YLR022c.
- Caenorhabditis elegans hypothetical protein W06E11.4.
- Methanococcus jannaschii hypothetical protein MJ0592.
This particular protein sequence is highly conserved in species ranging from archaea to vertebrates and plants.[2]
The SBDS protein contains three domains, an N-terminal conserved FYSH domain, central helical domain and C-terminal domain containing an RNA-binding motif.[4]
SBDS N-terminal domain
SBDS protein N-terminal domain | |||||||||
Identifiers | |||||||||
Symbol | SBDS | ||||||||
Pfam | PF01172 | ||||||||
InterPro | IPR019783 | ||||||||
SCOP | 1nyn | ||||||||
SUPERFAMILY | 1nyn | ||||||||
This protein domain appears to be very important, since mutations in this domain are usually the cause of Shwachman-Bodian-Diamond syndrome. It shares distant structural and sequence homology to a protein named YHR087W found in the yeast Saccharomyces cerevisiae. The protein YHR087W is involved in RNA metabolism, so it is probable that the SBDS N-terminal domain has the same function.[6]
The N-terminal domains contains a novel mixed alphabeta fold, four beta-strands, and four alpha-helices arranged as a three beta stranded anti-parallel-sheet.[6]
SBDS central domain
The function of this protein domain has been difficult to elucidate. It is possible that it has a role in binding to DNA or RNA. Protein binding to form a protein complex is also another possibility. It has been difficult to infer the function from the structure since this particular domain structure is found in archea.[6]
This domain contains a very common structure, the winged helix-turn-helix.[6]
SBDS C-terminal domain
SBDS protein C-terminal domain | |||||||||
Identifiers | |||||||||
Symbol | SBDS_C | ||||||||
Pfam | PF09377 | ||||||||
InterPro | IPR018978 | ||||||||
SCOP | 1nyn | ||||||||
SUPERFAMILY | 1nyn | ||||||||
In molecular biology, the SBDS C-terminal protein domain is highly conserved in species ranging from archaea to vertebrates and plants.[7]
Members of this family are thought to play a role in RNA metabolism.[6] However, its precise function remains to be elucidated. Furthermore, its structure makes it very difficult to predict the protein domain's function.[6]
The structure of the C-terminal domain contains a ferredoxin-like fold[8] This structure has a four-stranded beta-sheet with two helices on one side.[6]
Clinical significance
Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome .[3] The two most common mutations associated with this syndrome are at positions 183–184 (TA→CT) resulting in a premature stop-codon (K62X) and a frameshift mutation at position 258 (2T→C) resulting in a stopcodon (C84fsX3).[4]
- ^ PDB 2L9NFinch AJ, Hilcenko C, Basse N, Drynan LF, Goyenechea B, Menne TF, González Fernández A, Simpson P, D'Santos CS, Arends MJ, Donadieu J, Bellanné-Chantelot C, Costanzo M, Boone C, McKenzie AN, Freund SM, Warren AJ (May 2011). "Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome". Genes Dev. 25 (9): 917–29. doi:10.1101/gad.623011. PMC 3084026. PMID 21536732.
- ^ a b c Boocock GR, Morrison JA, Popovic M, Richards N, Ellis L, Durie PR, Rommens JM (Jan 2003). "Mutations in SBDS are associated with Shwachman-Diamond syndrome". Nat Genet 33 (1): 97–101. doi:10.1038/ng1062. PMID 12496757.
- ^ a b c "Entrez Gene: SBDS Shwachman-Bodian-Diamond syndrome".
- ^ a b c Orelio C, van der Sluis RM, Verkuijlen P, Nethe M, Hordijk PL, van den Berg TK, Kuijpers TW (2011). "Altered intracellular localization and mobility of SBDS protein upon mutation in Shwachman-Diamond syndrome". PLoS ONE 6 (6): e20727. doi:10.1371/journal.pone.0020727. PMC 3113850. PMID 21695142.
- ^ Sen S, Wang H, Nghiem CL, Zhou K, Yau J, Tailor CS, Irwin MS, Dror Y (December 2011). "The ribosome-related protein, SBDS, is critical for normal erythropoiesis". Blood 118 (24): 6407–17. doi:10.1182/blood-2011-02-335190. PMID 21963601.
- ^ a b c d e f g h Savchenko A, Krogan N, Cort JR, Evdokimova E, Lew JM, Yee AA, Sánchez-Pulido L, Andrade MA, Bochkarev A, Watson JD, Kennedy MA, Greenblatt J, Hughes T, Arrowsmith CH, Rommens JM, Edwards AM (May 2005). "The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism". J. Biol. Chem. 280 (19): 19213–20. doi:10.1074/jbc.M414421200. PMID 15701634.
- ^ Boocock GR, Morrison JA, Popovic M, Richards N, Ellis L, Durie PR, Rommens JM (January 2003). "Mutations in SBDS are associated with Shwachman-Diamond syndrome". Nat. Genet. 33 (1): 97–101. doi:10.1038/ng1062. PMID 12496757.
- ^ Shammas C, Menne TF, Hilcenko C, Michell SR, Goyenechea B, Boocock GR et al. (2005). "Structural and mutational analysis of the SBDS protein family. Insight into the leukemia-associated Shwachman-Diamond Syndrome.". J Biol Chem 280 (19): 19221–9. doi:10.1074/jbc.M414656200. PMID 15701631.
Further reading
- Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
- Popovic M, Goobie S, Morrison J, et al. (2002). "Fine mapping of the locus for Shwachman-Diamond syndrome at 7q11, identification of shared disease haplotypes, and exclusion of TPST1 as a candidate gene.". Eur. J. Hum. Genet. 10 (4): 250–8. doi:10.1038/sj.ejhg.5200798. PMID 12032733.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Nakashima E, Mabuchi A, Makita Y, et al. (2004). "Novel SBDS mutations caused by gene conversion in Japanese patients with Shwachman-Diamond syndrome.". Hum. Genet. 114 (4): 345–8. doi:10.1007/s00439-004-1081-2. PMID 14749921.
- Woloszynek JR, Rothbaum RJ, Rawls AS, et al. (2004). "Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome.". Blood 104 (12): 3588–90. doi:10.1182/blood-2004-04-1516. PMID 15284109.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Kuijpers TW, Alders M, Tool AT, et al. (2005). "Hematologic abnormalities in Shwachman Diamond syndrome: lack of genotype-phenotype relationship.". Blood 106 (1): 356–61. doi:10.1182/blood-2004-11-4371. PMID 15769891.
- Austin KM, Leary RJ, Shimamura A (2005). "The Shwachman-Diamond SBDS protein localizes to the nucleolus.". Blood 106 (4): 1253–8. doi:10.1182/blood-2005-02-0807. PMC 1895203. PMID 15860664.
- Kawakami T, Mitsui T, Kanai M, et al. (2005). "Genetic analysis of Shwachman-Diamond syndrome: phenotypic heterogeneity in patients carrying identical SBDS mutations.". Tohoku J. Exp. Med. 206 (3): 253–9. doi:10.1620/tjem.206.253. PMID 15942154.
- Boocock GR, Marit MR, Rommens JM (2006). "Phylogeny, sequence conservation, and functional complementation of the SBDS protein family.". Genomics 87 (6): 758–71. doi:10.1016/j.ygeno.2006.01.010. PMID 16529906.
- Erdos M, Alapi K, Balogh I, et al. (2007). "Severe Shwachman-Diamond syndrome phenotype caused by compound heterozygous missense mutations in the SBDS gene.". Exp. Hematol. 34 (11): 1517–21. doi:10.1016/j.exphem.2006.06.009. PMID 17046571.
- Nishimura G, Nakashima E, Hirose Y, et al. (2007). "The Shwachman-Bodian-Diamond syndrome gene mutations cause a neonatal form of spondylometaphysial dysplasia (SMD) resembling SMD Sedaghatian type.". J. Med. Genet. 44 (4): e73. doi:10.1136/jmg.2006.043869. PMC 2598034. PMID 17400792.
- Calado RT, Graf SA, Wilkerson KL, et al. (2007). "Mutations in the SBDS gene in acquired aplastic anemia.". Blood 110 (4): 1141–6. doi:10.1182/blood-2007-03-080044. PMC 1939897. PMID 17478638.
- Wang Y, Yagasaki H, Hama A, et al. (2007). "Mutation of SBDS and SH2D1A is not associated with aplastic anemia in Japanese children.". Haematologica 92 (11): 1573. doi:10.3324/haematol.11568. PMID 18024409.
External links
This article incorporates text from the public domain Pfam and InterPro IPR002140
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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
Shwachman-Bodian-Diamond syndrome (SBDS) protein Provide feedback
This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. It is characterised by bone marrow failure and leukemia predisposition. Members of this family play a role in RNA metabolism [2] [3]. In yeast these proteins have been shown to be critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes [4]. This data links defective late 60S subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition [4].
Literature references
Boocock GR, Morrison JA, Popovic M, Richards N, Ellis L, Durie PR, Rommens JM; , Nat Genet 2003;33:97-101.: Mutations in SBDS are associated with Shwachman-Diamond syndrome. PUBMED:12496757 EPMC:12496757
Savchenko A, Krogan N, Cort JR, Evdokimova E, Lew JM, Yee AA, Sanchez-Pulido L, Andrade MA, Bochkarev A, Watson JD, Kennedy MA, Greenblatt J, Hughes T, Arrowsmith CH, Rommens JM, Edwards AM; , J Biol Chem 2005; [Epub ahead of print]: The SHWACHMAN-Bodian-diamond syndromeprotein family is involved in RNA metabolism. PUBMED:15701634 EPMC:15701634
Shammas C, Menne TF, Hilcenko C, Michell SR, Goyenechea B, Boocock GR, Durie PR, Rommens JM, Warren AJ; , J Biol Chem 2005; [Epub ahead of print]: Structural and mutational analysis of the SBDS protein family: insight into the leukemia-associated shwachman-diamond syndrome. PUBMED:15701631 EPMC:15701631
Menne TF, Goyenechea B, Sanchez-Puig N, Wong CC, Tonkin LM, Ancliff PJ, Brost RL, Costanzo M, Boone C, Warren AJ; , Nat Genet. 2007;39:486-495.: The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. PUBMED:17353896 EPMC:17353896
External database links
Pseudofam: | PF01172 |
SCOP: | 1nyn |
This tab holds annotation information from the InterPro database.
InterPro entry IPR019783
This entry represents the N-terminal domain of proteins that are highly conserved in species ranging from archaea to vertebrates and plants [PUBMED:12496757]. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS, OMIM 260400) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. It is characterised by bone marrow failure and leukemia predisposition. Members of this family play a role in RNA metabolism [PUBMED:15701631, PUBMED:15701634]. In yeast Sdo1 is involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with the EF-2-like GTPase RIA1 (EfI1), it triggers the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. This data links defective late 60S subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition [PUBMED:17353896].
A number of uncharacterised hydrophilic proteins of about 30 kDa share regions of similarity. These include,
- Mouse protein 22A3.
- Saccharomyces cerevisiae chromosome XII hypothetical protein YLR022c.
- Caenorhabditis elegans hypothetical protein W06E11.4.
- Methanocaldococcus jannaschii (Methanococcus jannaschii) hypothetical protein MJ0592.
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (103) |
Full (652) |
Representative proteomes | NCBI (614) |
Meta (94) |
Jalview | ||||||||
PP/heatmap | 1 | |||||||
Pfam viewer |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (103) |
Full (652) |
Representative proteomes | NCBI (614) |
Meta (94) |
Raw Stockholm | ||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
External links
MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Seed source: | Prosite |
Previous IDs: | UPF0023; |
Type: | Family |
Author: | Finn RD, Bateman A, Moxon SJ, Mistry J, Wood V |
Number in seed: | 103 |
Number in full: | 652 |
Average length of the domain: | 91.60 aa |
Average identity of full alignment: | 36 % |
Average coverage of the sequence by the domain: | 38.64 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details: |
Model length: | 91 | ||||||||||||
Family (HMM) version: | 13 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
Sunburst controls
ShowThis visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
Tree controls
HideThe tree shows the occurrence of this domain across different species. More...
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There is 1 interaction for this family. More...
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SBDS domain has been found. There are 7 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
Loading structure mapping...


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College Gameday Thread: Week 1
Thursday night: North Carolina vs #6 South Carolina (ESPN) Tulsa vs Bowling Green (ESPNU) Utah vs Utah State (FS1) Ole Miss vs Vanderbilt (ESPN) Rutgers vs Fresno State (ESPNU) #24 USC vs Hawaii (CBSS) Friday night: FAU vs Miami (ESPNU) Texas Tech vs SMU (ESPN) ND State vs Kansas State (FS1) Saturday noon: Buffalo vs #2 Ohio State (ESPN2) Purdue vs Cincinnati (ESPNU) W&M vs West Virginia (FS1) Rice vs #7 Texas A&M (ESPN) Saturday afternoon: Mississippi State vs #13 Oklahoma State (ABC/ESPN2) Temple vs #14 Notre Dame (NBC) Syracuse vs Penn State (ABC/ESPN2) BYU vs UVA (ESPNU) Nicholls State vs #3 Oregon (FS1) #1 Alabama vs Virginia Tech (ESPN) Saturday night: Washington State vs Auburn (ESPNU) #5 Georgia vs #8 Clemson (ABC) #12 LSU vs #20 TCU (ESPN) #19 Boise St vs Washington (FS1) #22 Northwestern vs Cal (ESPN2) Sunday afternoon: Ohio vs #9 Louisville (ESPN) Monday night: #11 FSU vs Pittsburgh (ESPN) |
Looking forward to UGA/Clemson. If Murray plays well it should help his stock - don't understand that if Boyd is getting first round consideration why Murray isn't.
Game day tomorrow! WOOOOOOOOOOOO
Nkemdiche time. |
Stupid US Open being on so ESPN2 can't be showing a game. But I'm still going to have my computer on the coffee table running UCF-Akron, the big screen playing UNC-South Carolina, and then I'll bring the other big screen in, put it right next to the other one and watch Tulsa-Bowling Green. It will be fantastic.
Roll Tide Rollllllll!!!!
Finally week 1 is here! Even though we will be .500 at best this year, I've been waiting for 7 months for college football season.
Going to the Iowa game Saturday, I won't be surprised if it's a close game but I will laugh if we win. I know it's NIU, but we were so bad last year I don't know what to expect. |
I thought those facemasks got outlawed? |
Only in the NFL (I think).
But basically every DL has them now so they aren't nearly as cool anymore. |
Unless it's on Robert Nkemdiche, then it's cool as ****.
It's on
What i'd like to see is TAMU sit Manziel for the Rice game so we can stop hearing the constant talk about signing autographs. |
Go Dores!!!! Wooooo!
Georgia-Clemson will have all my attention Saturday night. As a FSU fan, I will root for Clemson to represent the ACC well, but it never bothers me watching Dabo get smacked around either.
I asked my mom who she's cheering for since she's from Georgia & went to school at Clemson & she just laughed.
Manziel will be suspended the first half against Rice.
Boise St at Washington could be a tough one for the Huskies. Sefarian Jenkins hasn't been cleared to play and Peterson seems to always have his team ready.
Kasen Williams (UW) and Matt Miller (Boise st.) are a couple of big WRs to keep an eye on. |
Considering a team is going to hand him millions next year, I think his mom will be ok without that.
Why put off what you can have now!!!
A&M suspended him for being a dumbass, NCAA didn't do anything.
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Source: FOOTYMAD
Henderson plays in England draw
Jordan Henderson helped England under 21's to a draw with Spain last night. Liverpool's new signing played the full 90 minutes as England under 21's drew 1-1 with Spain in their opening game of the UEFA Under 21's European Championships. Henderson also captained England after regular skipper Michael Mancienne was subsituted after 67 minutes. In the other game in the group the Czech Republic beat Ukraine 2-1.


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Palmieri has three goals and two assists in six games, tying him for the team lead in goals and points. His plus-5 leads the Ducks.
He's been able to accomplish this in just 10:19 time on ice per game. His highest total was 12:59 in Game 1; in Game 6, he skated just 8:45.
But he scored a game-tying goal in Game 5. In Game 6, he scored his third goal of the playoffs on a bit of a lucky bounds off of Red Wings defender Brendan Smith:
A video or other embedded content has been hidden. Click here to view it.
He's even survived a Kronwall'ing in this series.
The fourth line for the Ducks has been among their best, as Palmieri, Emerson Etem and David Steckel have made the most of their minutes. Said Coach Bruce Boudreau to the Detroit News:
"I think that's been a strength all year," Anaheim coach Bruce Boudreau said after his team's morning skate. "If you look at the teams, we were in the top 10 in scoring and nobody with more than 15 goals. I think it's a good thing that if one line is not going at any point in a game or for a couple games, we've got other lines to pick up the slack."
The Ducks and Red Wings faceoff in a Game 7 on Sunday. They'll need more heroics from players like Palmieri, even in limited minutes, to overcome Detroit.
- Sports & Recreation
- Ice Hockey
- Kyle Palmieri
- Anaheim Ducks
- Detroit Red Wings


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There was a time when Pro Street cars ruled the show circuit and even the pages of magazines. They looked fast, but they seemed relegated to idling through fairgrounds or maybe the occasional clandestine blast down a deserted street. The look was race car, but they soon gained an almost poseur status. Why? Because there was something wrong with a car all gussied up to dance just sitting it out.
The same phenomenon started happening in the Pro Touring segment. These cars looked ready for the Nürburgring, but never got put to the test. Then someone came up with a novel idea: How about sticking these worked-over classics on a track and seeing what they can do? The result was a hit and soon guys were building cars that not only looked good, but could throw down in the twisties as well.
Three years ago the folks at Optima Batteries decided to kick this trend up a few notches by organizing a shootout where the best handling cars in the country would vie for top honors. Since that inaugural race the rules for the Optima Ultimate Street Car Invitational (OUSCI) have morphed and the competition level has racked up, but the goal is the same: cool custom and Pro Touring cars fighting it out with imports and exotics to see who is the fastest of the fast.
There are three ways to get a golden ticket to run at this gig: win one of the regional qualifying events, catch the eyes of the event organizers, or snag one of the 10 invites handed out at the SEMA show in Vegas. But, we'll tell you one thing—getting in is a lot easier than winning.
Rule Book
Similar to last year, the three driving events were scored using a points system, where the top 20 finishers were awarded from 25 points (First Place) to 1 point (20th Place). This meant the cars had to consistently perform in all three driving challenges to win the big prize.
The biggest change was to the Raybestos Performance Design Challenge, which used to be judged on a 1-10. This year it was modified so that it factored in just like the driving events (1-25 point scale for the top 20 cars). Last year it was more of a tiebreaker, but now it was 25 percent of the final tally. Cars not finishing all of the events would be DQ'd out of the competition.
The other way to gain, or lose, points was in the Detroit Speed–sponsored road rally. This segment took place the night before the event and required all cars to make the 60-plus miles from the SEMA show in Vegas to the town of Pahrump. Rain, snow, and ice along the way just made it more challenging, especially for a car lacking things like wipers, heaters, and side glass. Competitors who made the trek within the given time picked up 10 points.
The Hot Lap Challenge, sponsored by BFGoodrich, consisted of a warm-up lap, followed by three timed laps and one cooldown lap. The RideTech-sponsored autocross consisted of three timed laps with no practice runs. Hitting a cone added a second to the final time and missing a turn resulted in a big fat DNF. In the Wilwood Brakes–sponsored Speed/Stop Challenge, drivers combined launch speed with braking prowess to traverse the given distance, stopping in the coned-off box, in the least amount of time. Even touching a cone in the stop box earned a DNF; it's a tricky event that can flat spot tires in a heartbeat. The competitor's best time in each event was used to determine the number of points they would accumulate. The other big rule was that the tires had to be 200 or greater treadwear.
The hardest part of an event like this is handling the drivers. After all, the point is to find the "Ultimate Street Car" and skill behind the wheel can make all the difference, especially on the road course and autocross. This year the rules were further tightened up so that only car owners and builders who've done at least 80 percent of the work can pilot the cars. Of course that doesn't keep the "pro" drivers out, but it does stop it from getting out of control. Last year's winner, Mark Stielow, was back to defend his title in his blown '69 Camaro. He has hundreds, if not thousands, of laps at Spring Mountain, so he certainly had an advantage. There were also some familiar faces like the Tuckers from Detroit Speed, national autocross champion Mary Pozzi, and Brian Finch. All of them ended up being 2-5 seconds faster than they were last year. So yes, practice does pay off. There were also new hot shoes piloting cars, including Mike Maier, Brian Hobaugh, Danny Popp, Pete Callaway, and Vinny Allegretta. Such a deep talent pool, combined with cars that blurred the lines between street car and race car, guaranteed an all-out war on the track, and we weren't disappointed.
Race Day
The weather on Friday was less than stellar; however, on Saturday morning we were greeted with blue skies. Even though the morning temps hovered in the mid 30s, it was better than the alternative. Around sunrise the drivers started trickling in and getting their cars ready for their tech inspection. The mood was friendly, but by the time the morning drivers' meeting got going you could tell that everything was getting a bit more serious. Let's admit it, a friendly competition is still a competition.
The desire to win never muddied the fact that everyone racing were friends with a common love of all things automotive. Last year's winner, Stielow, gave the other hot shoes tips on how best to navigate Spring Mountain's 2.1-mile road course and when there were mechanical issues, other drivers and support crew stepped up to lend a hand or needed tools. Near the end of the event, Popp cracked his brake master cylinder on the road course. Normally this would have ended his day, and his chances of winning, but Callaway, who was done with all of his events, gave him the master off of his '08 Corvette. It was a classy act indicative of the event; gearheads coming together to share their passion while trying to best each other out on the track. It's what makes this better, and to us far more enjoyable, than the "dog-eat-dog" mentality found in professional racing.
By the end of the event all of the expected names were on the leaderboard with 7 out of the top 10 being Chevrolets. Most importantly, for the third year out of four, a Chevy stood on the top rung of the ladder. Who knows what next year will bring, but we're sure of one thing; when November rolls around, we'll be there to watch the best of the best battle it out.
Top 10 Road Course |
Name | Vehicle | Time |
Danny Popp | '06 Z06 Vette | 1:42.208 |
Pete Callaway | '08 SC652 Vette | 1:44.749 |
Mark Stielow | '69 Camaro | 1:45.410 |
Kyle Tucker | '71 Camaro | 1:48.430 |
Gary Rubio | '09 Nissan GT-R | 1:48.441 |
Mike Maier | '66 Mustang | 1:48.721 |
Brian Hobaugh | '73 Camaro | 1:48.879 |
Filip Trojanek | '66 Mustang | 1:50.265 |
David Mikels | '10 Camaro | 1:51.319 |
Vincent Allegretta | '69 Camaro | 1:51.584 |
Top 10 Autocross |
Name | Vehicle | Time |
Danny Popp | '06 Z06 Vette | 38.251 |
Mary Pozzi | '73 Camaro | 39.414 |
Brian Hobaugh | '73 Camaro | 39.502 |
Pete Callaway | '08 SC652 Vette | 39.626 |
Mike Maier | '66 Mustang | 39.654 |
Brian Finch | '69 Camaro | 39.658 |
Mark Stielow | '69 Camaro | 40.017 |
Kyle Tucker | '70 Camaro | 40.031 |
Gary Rubio | '09 Nissan GT-R | 40.117 |
Mark Rife | '63 Corvette | 40.167 |
Top 10 Speed-Stop |
Name | Vehicle | Time |
Gary Rubio | '09 Nissan GT-R | 6.541 |
Mark Stielow | '69 Camaro | 7.096 |
Danny Popp | '06 Z06 Vette | 7.378 |
Mary Pozzi | '73 Camaro | 7.413 |
Mike Maier | '66 Mustang | 7.425 |
Brian Finch | '69 Camaro | 7.479 |
Terry Neuville | '68 Camaro | 7.491 |
Filip Trojanek | '66 Mustang | 7.530 |
James Shipka | '67 Camaro | 7.545 |
Joe Shown | '90 ZR1 Vette | 7.568 |
Top 5 Finishers –Style Category |
Name | Vehicle | Place |
Phil Gerber | '67 Chevelle | 1st |
Curt Ukasik | '62 Nova | 2nd |
JF Launier | '57 Bel Air | 3rd |
Brian Hobaugh | '73 Camaro | 4th |
Mike Langford | '01 PT Cruiser | 5th |
Overall Winners |
Name | Vehicle | Place |
Danny Popp | '06 Z06 Vette | 1st |
Mark Stielow | '69 Camaro | 2nd |
Brian Hobaugh | '73 Camaro | 3rd |
Gary Rubio | '09 Nissan GT-R | 4th |
Mary Pozzi | '73 Camaro | 5th |


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patricia A murray
patricia A's Contributions
patricia A murray hasn't written any articles yet.
About patricia A murray
Originally from Chicago, she is publisher of the online community paper, the Durham Skywriter. She also hosts Radio Skywriter on Durham, North Carolina's local jazz station, WNCU / wncu.org and will soon be hosting an online live-streaming program, TV Skywriter, which will feature musicians from around the world.
patricia A murray joined the JazzTimes community on Nov 08, 2012


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Mushroom farmers work to expand in Missouri
Many Missourians have opted to grow their own mushrooms, but the task is not easy. Mushroom farmers must exercise a great amount of patience and care to yield the final product, which often doesn't bring in enough profit to make a living.
Arborists work to preserve McBaine bur oak tree
Arborists have been taking wood samples from the popular McBaine oak tree, using them to create little clone trees called grafts in order to preserve the 350-year-old tree's DNA.
Columbia developer to move forward on cottages project
Amir Ziv hopes to break ground on the cottages, but must follow several city requirements.
Sculpture garden opens in downtown St. Louis
The three-acre Citygarden, which was funded with $30 million from the nonprofit Gateway Foundation, is free to the public and offers an audio tour including the voices of St. Louis leaders such as Hall of Fame Cardinal Ozzie Smith.
Timeline of Michael Jackson's life and career
Take a look at the many successes and controversies of the King of Pop, from his days in the Jackson 5 to his death on Thursday.
Police tow car, seek clues in Jackson death
Brian Oxman, a former Jackson attorney and a family friend, said Friday he had been concerned about Jackson's use of painkillers and had warned the singer's family about possible abuse.
Jackson broke barriers long before 'Thriller'
When Michael Jackson premiered in the 1972 movie "Ben," his voice and charm gave black America an idol to cheer for.
Autopsy planned after Jackson's sudden death
Authorities are hoping to find out whether prescription drugs were involved in Michael Jackson's death. An autopsy was scheduled to begin today, though results likely won't be final until toxicology tests can be completed.
World leaders, musicians mourn King of Pop
Nelson Mandela, Paul McCartney and many more friends and fans around the world mourned Michael Jackson's death and recalled the person he was.
TV helped shape Jackson's image
For better or worse, Michael Jackson was always something to see. His career was shaped and showcased by television, and he was inseparable from the medium.
PHOTO GALLERY: World mourns 'king of pop'
Fans the world over mourned the loss of Michael Jackson after the pop icon died Thursday.
PHOTO GALLERY: Remembering Michael Jackson
The "king of pop" rose to stardom at an early age and quickly captured the hearts of millions. He died Thursday at age 50.
Lost icons: For Generation X, a really bad day
In the 1990s, members of Generation X would sit in bars and laugh about the naivete of the 1960s. Today, they sit around and tell stories about the death of the kings of pop.
'Bruno' premiere blocks Jackson's Walk of Fame star
The Sacha Baron Cohen film was screening at Grauman's Chinese Theatre, right next to Jackson's star. Fans trying to get a glimpse Thursday were turned back.
MU Tour Team helps visitors stay cool
The MU Tour Team is doing its best to help visitors and prospective students touring campus by providing water, staying inside as much as possible and taking it slow.
Film crew wraps up Shakespeare's scenes as movie production continues
The fictional movie, "10 Hours a Week," is based on the experiences of a former Shakespeare's Pizza employee and features mostly local actors.
FRANK looks to foster art appreciation among young adults
The group, sponsored by the Missouri Theatre, attempts to cater to the 20- 30-something age range and is "trying to bridge the gap between stuffy classical music and the contemporary." Its monthly meetings bring together a diverse group of young professionals to discuss the arts in an informal atmosphere.
Columbia artist uses nature as inspiration
For fiber artist Jo Stealey, being an artist is more than a job or a way to make a living – it is a way of life.
Columbia's Wine and Food Festival to begin Saturday
The Columbia Wine and Food Festival is scheduled to begin Saturday, followed by eight days of events. Ten local chefs are to create dinners and hors d'oeuvres that are intended to pair nicely with wine tastings. More than 180 wineries are expected to bring wines — more than 400 varieties — to taste throughout the festival.
Concern over food quality, prices leads to home food preservation
MU Extension workshops in food preservation are filling up this year as more people appear to take stock in the quality of their food and the contents of their wallet.


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Bypass the wholesaler
Suppose the president of a carpet manufacturing firm has asked you to look into the possibility of bypassing the firm's wholesalers (who sell to carpet, department, and furniture stores) and selling direct to these stores. What caution would you voice on this matter, and what type of information would you gather before making this decision?
Solution Summary
Bypassing the wholesaler is discussed in great detail in this solution.


text: Additional file 1.Ka/Ks estimation based on model selection using KaKs_Calculator. The data represent the average pairwise ratio of nonsynonymous to synonymous substitutions (dN/dS) for sequences in six subfamily. Format: DOC Size: 92KB Download file This file can be viewed with: Microsoft Word Viewer Gong et al. BMC Genomics 2009 10:332 doi:10.1186/1471-2164-10-332 |


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Frederick, MD – Free Green Smoothie Girl ClassGreen Smoothie GirlTuesday, April 23, 2013 from 7:00 PM to 8:00 PM |
7:00 pm "Change Your Nutrition with Just 10 Minutes a Day"--Presented by Green Smoothie Girl Health Coach Karen Vasecka
Free green smoothie class, demo, and sampling! Learn to radically change your nutrition in just 10 minutes a day, and leave inspired and empowered to transition to a whole-foods diet!
We ticket these free events so we can plan for seating and samples. However, you may come with or without your ticket. Thanks for registering for one so we can accommodate everyone!
**There is a parking garage at the corner of West Patrick and Court Street.
Green Smoothie Girl
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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NCAAB Savannah State vs. Ohio State, 12/12/2012 19:00 Ohio State -22½/-110 NCAAB Oregon State vs. Portland State, 12/12/2012 22:35 Oregon State -725 To see more of chargerrodger's plays click here.
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Good Luck tonight Rodger!


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Kelly Ricardson: Teen doesn't like sister's sorority friend
Dear Kelly : My older sister went to college a year ago and joined a sorority. This year she got a little sister, who came to visit us at Christmas. She kept calling my sister her "big sister," and my sister kept calling her "my little sister." It started to drive me crazy, and apparently I was "rude and unfriendly" when she was here. Later I saw on my sister's Twitter "Love hanging with my little sister #shesthebest," and at first I thought she was talking about me because we used to be really close, but then I realized she was talking about her sorority sister. Her little sister retweeted it and then wrote "I am so happy I finally have a true big sister #sisters4life" because she has two brothers. I ended up unfollowing both of them because it made me too mad to see it.
When I look on her Instagram now it's all these pictures of the two of them, so it seems like they are always together at college, too. My mom suggested I go visit my sister for a weekend so we can spend time together. I refuse to go because my sister would probably want me to hang with her little sister while I'm there, and I know that would make me want to leave, and it might get ugly.
What should I do? I can't stand my sister's "little sister" (she's really annoying), and now my sister is saying she might come spend Easter with us because she can't afford to fly home. I don't want her to visit and told my parents this. My mom says she's now in the middle and she hates it. My mom likes my sister's sorority sister so I know what she's going to do, and I know how mad I'm going to be. Shouldn't I be able to say no to her visiting on a family holiday if I don't like her and it will ruin my Easter?
– Sad Sister
Dear Sad Sister: It seems there are two issues here: Your feelings about your sister's sorority sister and what to do about Easter. Let's start with how you feel about their relationship.
Whether you want to hear this or not, this is an issue of jealousy. Feeling jealous can set off a chain reaction of emotions that cause people to do or say things they may not mean. It seems like you feel replaced and your feelings are hurt. When you feel replaced by someone else or like you don't matter to them, the typical response is anger and jealousy. This causes you to create stories in your mind that typically aren't true about how the other person feels about you and devalues your place in their life. These hurt feelings can cause you to say and do things you might regret because you are reacting from a place of emotion and pain.
Step back so you can get some clarity on the situation. Awareness can help guide us to better understanding how we feel and why we react the way we do. Look at what transpired and how you felt. Did your sister or her sorority sister do anything wrong? Not really. Could they have shown some sensitivity to your feelings? Perhaps. Did you help the situation by being rude and unfriendly? Absolutely not. Anger and jealousy will not endear someone to want to be closer to us. What you really wanted you pushed away with your behaviors.
The reality of this is that your sister still loves you and you are still her little sister, even though she calls someone else that right now. A sorority sister is not the same as a blood sister. You have not been replaced, nor does she love her sorority sister the same as she loves you.
Reconsider your mom's suggestion. Go visit your sister. Spend some time together. Have fun. Laugh and talk. Share your feelings with her – not in a blaming manner but rather in a hurt way. Take ownership for how you behaved (yes, it was poor choices) and apologize if you put her in an uncomfortable place. Perhaps if she knows how you feel, she will be more aware of what she calls her little sister in front of you and how it might make you feel. Go into the weekend with a different mindset besides "this could get ugly." Focus on reconnecting with your sister and letting go of all the anger and jealous feelings. The sooner you stop being angry, the better you will feel.
Give your sister's little sister another chance. Your mom likes her, and so does your sister. Maybe if you weren't feeling so jealous and envious you might have liked her as well. Don't make a decision on Easter until you have given her a fair chance to get to know her. Treat her the way you would want to be treated and you might find yourself with a new friend.
Don't compare yourself to your sister's sorority sister. Value your place in her life by being confident in the relationship and the history the two of you share. Your sister can like her new little sister and still love you. You are two different people and can have two different roles in her life.
Kelly Richardson, a Folsom therapist, works with adolescents.
About This Blog
Kelly Richardson, a Folsom therapist, writes a weekly column for The Sacramento Bee. Her practice focuses on adolescents, and she believes proper communication and clear boundaries help build strong and lasting relationships. Write to Kelly Richardson Email email@example.com or send to Teen Talk, The Sacramento Bee, P.O. Box 15880, Sacramento, CA 95852Join the Discussion
The Sacramento Bee is pleased to provide this opportunity to share information, experiences and observations about what's in the news. Some of the comments may be reprinted elsewhere on the site or in the newspaper. We encourage lively, open debate on the issues of the day, and ask that you refrain from profanity, hate speech, personal comments and remarks that are off point. Thank you for taking the time to offer your thoughts.


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You And I Are Disappearing--Bjorn Hakansson
The cry I bring down from the hills
belongs to a girl still burning
inside my head. At daybreak
she burns like a piece of paper.
in a thigh-shaped valley.
A skirt of flames
dances around her
at dusk.
We stand with our hands
while she burns
like a sack of dry ice.
She burns like a cattail torch
dipped in gasoline.
She glows like the fat tip
of a banker's cigar,
silent as quicksilver.
    at nightfall.
She burns like a shot glass of vodka.
She burns like a field of poppies
at the edge of a rain forest.
She rises like dragonsmoke
    to my nostrils.
She burns like a burning bush
driven by a godawful wind.


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Home | |
CHEMICAL ENGINEERINGPRESERVING BACTERIA THROUGH A HEALTHY COLLABORATIONProfessor Juan de Pablo is working to create freeze-dried probiotics that have superior stability, a longer shelf-life and the ability to survive in greater numbers at room temperature. Probiotics are health-enhancing bacteria found predominantly in yogurt, fermented milks and dietary supplements. They are credited with numerous health benefits including warding-off intestinal tract infections, modulating the immune system, helping the body produce B vitamins and aiding in dairy product digestion. de Pablo's group developed patent-pending formulations optimized to suit each type of probiotic. "We have a general class of chemicals and materials that can be used for cryopreservation, or freeze-drying, of biological systems," said de Pablo. "We have tested these products on enzymes and proteins, and more recently also on bacteria. We've demonstrated the efficacy of these methods on several classes of bacteria, and we have created optimized formulations that offer an economically attractive alternative to what is currently being done in industry." NEW CLASS OF SENSORS FASHIONED FROM LEDsAlready glowing away on thousands of consumer electronics products, the light-emitting diode (LED) is proving to be a remarkably versatile device. A group of UW-Madison scientists, including Professor Thomas Kuech, Electrical and Computer Engineering Associate Professor Luke Mawst and Chemistry Professor Art Ellis, have demonstrated the LEDs' usefulness as chemical sensors. Chemical exposure can alter the surface structure of LED materials, causing the intensity of the light to fluctuate. That resulting light change can be put to use in simple, highly sensitive systems that sense chemicals in the air or water. "There's a big movement to make sensors smaller, more versatile and to use the economy of scale you get from the semiconductor industry," said Kuech "What's nice about this effort is the prospect of making tiny optical emitters and detectors that are chemically sensitive to a wide range of substances you would care about in the environment." FAST, CHEAP AND PORTABLE A NEW PATHOGEN DETECTION TOOLProfessor Nicholas Abbott's advances in liquid crystals may help in the quest for early detection of pathogens like foot and mouth disease, West Nile virus, cryptosporidum or E. coli. By using liquid crystals in combination with nanostructured surfaces, Abbott's credit card-sized plastic chips can offer rapid detection of bacteria or a virus. When exposed to a specific pathogen, the tendency to organize will make the presence of microscopic bugs visible to the naked eye. The inventors first use techniques of nanofabrication to alter the surface of their device with ridges and bumps that match the size of contours of a species of virus or bacteria. The next step is to expose the surface to a field sample. A liquid crystal surface is laid over the sample. If the pathogen is in the sample, the liquid crystals will change color or brightness. "We're seeing an increasing focus on food pathogens and emerging diseases," said Abbott. "We really don't have methods of detection in use now that are rapid, robust and inexpensive." |


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Pic # 1 is The Cove
Pics 2 & 3 are Head Quarters
Pic 4 my surfing motivation
yea i was gonna say that 3 would be steggars as my next choice. hows cape may i havent been there for a while, i need to get back up
Can you guess what this animal is ?
Some damn good photoshop-animal
phone pics ... but you get the idea
This is a surfboard that I'm currently shaping under Dave Yearwood's masterful eye. I was bored, and didn't really feel like doing a chemistry lab write-up, so this is what I did instead.


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02-17-2013, 03:36 PM | #1 (permalink) |
New Member
Join Date: Dec 2012
Posts: 13
Timid / Terrified
My wife and I have a 7 month old German Shepard dog female named Lola. We have officially had her for 2.5 months now and are working with her as much as we can to socialize her. The previous owner had her in the back of her home on a 10' long leader and was out in the country, so no dogs and no people. We saw her twice before purchasing her and she was timid around us....pulling away, staying near her owner, sniffing cautiously and then running the other way if we got closer to her. After having her for a couple of days, she warmed up to us and is great with us but has a horrible time around others, even kids. She is absolutely terrified of them. Today two children came over and when they were about to leave we found her in the shed cowering in a corner. She heard a child's voice after they were gone and took off towards her dog house and went into the corner and curled up. WHAT DO WE DO!??? HELP PLEASE. We bring her to a dog park 3-5 times a week and she does GREAT with the dogs there. She plays, runs around, etc, just like a normal dog. She will not, however, go near people. I'm not worried about what people think, but more worried about her having this fear of people and never being able to conquer it. Any help would be greatly appreciated. Thank you! Attached is a picture of our little girl about 3 weeks ago.
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02-17-2013, 03:52 PM | #2 (permalink) |
Knighted Member
Join Date: Jun 2010
Location: Midwest
Posts: 2,591
You're little girl is gorgeous. So glad she's off that lead.
You'll get a lot of good advice from the people here and I also suggest searching through the puppy section for socializing tips. What I suggest is that you seek out the help of your friends & family. If any of them have kids that have experience with dogs, invite them over. Its important that you don't invite kids over that have fear of dogs Have the kids just hang out with treats and let your girl come to them on her terms.
Carrie Mac - 4 year old GSD Bart - 9ish year old GSD/Akita & 3 Cats Buffy, Rusty & Magoo |
02-17-2013, 04:00 PM | #3 (permalink) |
New Member
Join Date: Dec 2012
Posts: 13
Mac's Mom,
Thanks so much for the quick reply and kind words. We gave them both treats for her to come to them as she relaxed but she never did. She would run away and go hide in the corner of the yard until she felt like she needed to move. It was so sad to see her like this. I've had neighbors take treats and stand completely still as to not startle her and she would not go near them. My little niece and nephew came over (both have no fear of dogs and have 2 of their own) and she wouldn't go near them. They are 3 and 5 years old. Neither are loud or spooked her, but she just wouldn't have it. I'll keep searching threads and wait for others to respond. Thanks! Your dogs are precious! |
02-21-2013, 01:38 PM | #5 (permalink) |
New Member
Join Date: Dec 2012
Posts: 13
Yesterday I went to take Lola for a walk and while walking out of the back yard, we ran into another couple who had a 11 month old female GSD. It was a husband and wife and one of their children around the age of 7-9 years old.
Lola FREAKED! She backed up under some holly bushes next to the house and was shaking. The dog went up to her and barked a few times directly in her face but she did not care. She was watching the boy the entire time. It was sad. Not until they had made the corner was I able to get her out of the bushes and on the walk. I'm so worried she will never make it through this stage! |
02-21-2013, 01:50 PM | #6 (permalink) |
Knighted Member
Join Date: Jul 2012
Location: Ohio
Posts: 2,683
THIS. Immediately. STOP putting the dog near children when the dog is scared to death of them!!!! Do you know what will likely be the outcome? She will be cornered (or feel cornered) and instead of 'flight' you're going to get 'fight'. She may end up doing serious damage to a child. You need SERIOUS help for her. Nothing that can be given over the internet except keep her away from children and get help! This may not just be a result of lack of socialization. It may be a result of poor breeding. You're seeing bad nerves. When you have the result of bad breeding, you can manage it... even make improvements, but it's nothing the dog is ever going to get 100% past. You bought a dog you shouldn't have bought. This isn't a 'plug and play' breed. Unfortunately, you have to have a decent amount of knowledge before buying a pup or dog of this breed so you have some idea of what you're getting into. There were red flags all over before you bought her. You didn't see them because you don't know the breed. I think you're in way over your head. If I were in your shoes, I'd find a rescue, trainer, etc. to try to place the dog with. She's going to need a LOT of training and management... and that management will likely be for the rest of her life. Without it, you're going to keep seeing what you're seeing, and maybe worse.
Wrath of Grim z Dragon "Mr. Grim"- Threaten my handler. I dare you. |
02-21-2013, 02:02 PM | #7 (permalink) |
Knighted Member
Join Date: Apr 2012
Posts: 3,436
Thanks for giving Lola a loving home! She may have been tormented by children when she was tied up all that time, you never know. My first GSD hated children too, but I don't know why because he was an adult when I adopted him. I kept him away from kids and he was fine otherwise. I'd just be careful with Lola in the dog park, since children will be there. Also with your family, until she's more comfortable around them.
02-21-2013, 02:07 PM | #8 (permalink) |
The Rescues Rule Administrator
Join Date: May 2005
Posts: 24,190
Hi - I am not sure if Lola is outside all day, but she will do better brought in the house so she can be around you more, learn more from you.
You absolutely do not want to have her around kids at this point. You do definitely want to find a really skilled, fearful dog experienced, positive trainer/behaviorist to help you. Slooooooow and steady is the idea. The Pet Professional Guild - Member directory https://www.karenpryoracademy.com/find-a-trainer Some more links to look at - that Shy k9 group is a must: This group is the best - just joining for the archives is good: shy-k9s : shy-k9s Fearfuldogs.com Good website, good info. May not work, Helping Shy Dogs Blossom Using Targeting | Karen Pryor Clicker Training but I clicked with my mouth, no treat since Anna wouldn't take, just to let her know that was a good/brave behavior. This is the very first site I read: http://kimmurphy.net/shy-k9s-faq.html |
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This took me about 16 hours to complete. Its acrylics on canvas in my own pop art style.
I take commissions if anyones interested
iconic, police, america, film, famous, celebrity, movies, cops, black and white, mel gibson, lethal weapon
Excellent. Congratulations on the feature!
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– Deborah Boyle
Wow, fantastic, I really love these films, they started so serious then it seemed to turn into a comedy, but you gotta love em. Awesome art:-)