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Texas Weather
Texas weather and I have a love-hate relationship. There are days when I marvel at how it is seventy-five and sunny for an entire week. On other days, it's easy to complain how it dropped from eighty-five at lunch to thirty-five at night.
Catching Up
Whoa. Hey there. I haven't seen you in a while. It's totally my fault. My finals week was busy and then I left Austin for Winter Break. Let me update you on what I've been up to.


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Well I get into the game, but it's always the same
I'm the man with the name, Hip Eponymous Poor Boy, boy
Call me whatever you may, I ain't stoppin' the train
I got a pill for the pain Hip Eponymous Poor Boy, boy
And I know that I can't defeat you
Yea, you don't worry now, I ain't going to preach to you
Well, there ya go
But I'll be going right there with you
Yeah wherever you'll be, you'll be lookin' at me
But don't get out of your chair
Put a bow in your hair, you might be makin' 'em stare
So leave the care to the poor boy, the boy
And that's the name of the game
Keep on stayin' the same, ain't nobody to blame
Nobody but the poor boy, the poor boy
Well okay, so you fell asleep today
What's funny to me though is that you did that yesterday
You might think I'm mad
To do all the things that I don't need to do
But while you're laughin' at me, well I'll be laughin' at you
So I get into the game, but always keep it the same
And I'll be usin' your name, but they'll be yellin' at me "Poor boy, boy"
But I'll be happy for you, cause you got nothin' to do
And I'll be singin' the blues, walkin' around singin' "Poor boy, boy"
Sometimes a cold shiver comes over me
And it turns me on when the song takes over me
But alright, I can't fight it the odds are against me
But I can't sit still
Because I know that I will
And you'll be watching me girl, takin' over the world
Let the stripes unfurl, gettin' rich singin' "Poor boy, boy"
And I'll be comin' to play, I do it every day
And the title will stay, Hip Eponymous Poor Boy, boy (Yeah)
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Jack White - Blunderbuss Album Lyrics | |
1. | Sixteen Saltines |
2. | Freedom At 21 |
3. | Love Interruption |
4. | Blunderbuss |
5. | Hypocritical Kiss |
6. | Weep Themselves To Sleep |
7. | I'm Shakin' |
8. | Trash Tongue Talker |
9. | Hip (Eponymous) Poor Boy |
10. | I Guess I Should Go To Sleep |
11. | Missing Pieces |
12. | On And On And On |
13. | Take Me With You When You Go |
Jack White Lyrics provided by SongLyrics.com
1 | Blue Light, Red Light (Someone's There) |
2 | Want and Able |
3 | I Think I Found The Culprit |
4 | That Black Bat Licorice |
5 | Entitlement |
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Editor for this issue: Marisa Ferrara <marisalinguistlist.org>
Title: Computer Learner Corpora, Second Language Acquisition and Foreign Language Teaching Series Title: Language Learning & Language Teaching 6 Publication Year: 2002 Publisher: John Benjamins http://www.benjamins.com/, http://www.benjamins.nl Book URL: http://www.benjamins.nl/cgi-bin/t_bookview.cgi?bookid=LL_LT_6 Availability: Available Editor: Sylviane Granger, Universit� Catholique de Louvain Editor: Joseph Hung, Chinese University of Hong Kong Editor: Stephanie Petch-Tyson, Universit� Catholique de Louvain Hardback: ISBN: 1588112934, Pages: x, 246 pp., Price: USD 80.00 Hardback: ISBN: 9027217017, Pages: x, 246 pp., Price: EUR 80.00 Paperback: ISBN: 1588112942, Pages: x, 246 pp., Price: USD 35.95 Paperback: ISBN: 9027217025, Pages: x, 246 pp., Price: EUR 36.00 Abstract: This book takes stock of current research into computer learner corpora conducted both by ELT and SLA specialists. It should be of particular interest to researchers looking to assess its relevance to SLA theory and ELT practice. Throughout the volume, emphasis is also placed on practical, methodological aspects of computer learner corpus research, in particular the contribution of technology to the research process. The advantages and disadvantages of automated and semi-automated approaches are analyzed, the capabilities of linguistic software tools investigated, the corpora (and compilation processes) described in detail. In this way, an important function of the volume is to give practical insight to researchers who may be considering compiling a corpus of learner data or embarking on learner corpus research. The volume is divided into three main sections: Section 1 gives a general overview of learner corpus research; Section 2 illustrates a range of corpus-based approaches to interlanguage analysis; Section 3 demonstrates the direct pedagogical relevance of learner corpus work. Table of Contents Preface vii List of contributors ix I. The role of computer learner corpora in SLA research and FLT A Birds-eye view of learner corpus research Sylviane Granger 3 II. Corpus-based approaches to interlanguage Using bilingual corpus evidence in learner corpus research Bengt Altenberg 37 Modality in advanced Swedish learners written interlanguage Karin Aijmer 55 A corpus-based study of the L2-acquisition of the English verb system Alex Housen 77 III. Corpus-based approaches to foreign language pedagogy The pedagogical value of native and learner corpora in EFL grammar teaching Fanny Meunier 119 Learner corpora and language testing: smallwords as markers of learner fluency Angela Hasselgren 143 Business English: Learner data from Belgium, Finland and the U. S. Ulla Connor, Kristen Precht and Thomas A. Upton 175 The TELEC secondary learner corpus: a resource for teacher development Quentin Grant Allan 195 Pedagogy and local learner corpora: working with learning-driven data Barbara Seidlhofer 213 Index 235 Lingfield(s): Computational Linguistics Language Acquisition Language Learning (Language Acquisition) Written In: English (Language Code: English)Mail to author|Respond to list|Read more issues|LINGUIST home page|Top of issue


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J. J. Renema, G. Frucci, Z. Zhou, F. Mattioli, A. Gaggero, R. Leoni, M. J. A. de Dood, A. Fiore, and M. P. van Exter, "Modified detector tomography technique applied to a superconducting multiphoton nanodetector," Opt. Express 20, 2806-2813 (2012)


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BANGKOK (AP) -- The price of oil fell Wednesday as investors waited for a report on U.S. crude stocks and the Federal Reserve's latest views on the U.S. economy.
Benchmark crude for July delivery was down 62 cents to $95.56 a barrel at late afternoon Bangkok time in electronic trading on the New York Mercantile Exchange. The June contract fell 55 cents to settle at $96.16 a barrel on Tuesday.
Ric Spooner, chief market analyst at CMC Markets in Sydney, said traders were keeping tabs on the Federal Reserve, whose chairman was to appear before Congress later Wednesday. Traders will be scrutinizing Bernanke's remarks for any hints of a change in monetary policy by the U.S. central bank.
Spooner also said that an increase in crude inventories of roughly 530,000 barrels reported by The American Petroleum Institute on Tuesday put downward pressure on prices. Analysts were expecting a decline of 1.2 million barrels in crude, according to a survey by Platts, the energy information arm of McGraw-Hill.
"Although we are into the driving season, it is still the case that inventory levels are high and production capacity is high, so I think there is a bit of risk to the downside," Spooner said.
A report by the U.S. Energy Department's Energy Information Administration, which is the market benchmark, will be out later Wednesday.
Brent crude, a benchmark for many international oil varieties, fell 92 cents to $102.99 a barrel on the ICE Futures exchange in London.
In other energy futures trading on Nymex:
— Wholesale gasoline fell 3.3 cents to $2.805 a gallon.
— Heating oil lost 3.4 cents to $2.885 a gallon.
— Natural gas added 3.3 cents to $4.225 per 1,000 cubic feet.
- Basic Materials Industry
- Finance
- New York Mercantile Exchange


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Nix Tharel |
For those that aren't aware - wife had our baby boy yesterday and we're in the throes of sleep cycle adaptation.
As for sleep, it is really helpful if you can work out a way that you can feed the baby once in a while, so your wife can get 3 or 4 hours of sleep at once.
Tal Bernard Mainz |
Does Pollux remind anyone else of a Johnny Depp who never quite let go of his Edward Scissorhands role?
Never thought of it that way, but now that you mention it...
Asmodia Crispin |
You... you mean he's going cast hold person and kick Thesing in the balls instead of sleep with him?
Btw, I'm the Cleric that plays that she doesn't have ANY wisdom. So I assume you're the smartest Wizard ever. Except that you're an enchanter and not a universalist... but, we'll just sweep that one under the rug
TarkXT |
You... you mean he's going cast hold person and kick Thesing in the balls instead of sleep with him?
No, Thesing is simply not trying to do him. As there are no females in the group in fact the only character he has decided to make a move on was one of the characters wives. After the play kills him.
Asmodia Crispin |
By my current count, we still have 39 charges on our CL Wand. Asmodia has cast no spells, although she could fix ability damage if they were to key members, like Bejis, Shade or Bloodless. Although, if either she or Aerieth take more CON damage, she might be persuaded to do so.
And probably roll a 1, just my luck.
Tal Bernard Mainz |
By readin ghte script, the only thing I know is I am safe the first 2 acts and then we geta fluke, digested by stomach acid, then something out of the movie Alien, and finally I get attacked by Cal and devils (don't know which is worse). How exactly that is going to take place I don't know. Hopefully we have lots of healing and my AC helps. That's all I know.
Aerieth Deventis |
Asmodia Crispin wrote:The puppy dogs are hellhounds and the awwhs are groans of sickening discomfort at what acid does to ones skin.Aerieth lies. it's all puppy dog kisses and empathetic "Awwwhs!" from the audience.
Trust me. I'm a cleric of Calistria. I wouldn't lie to you.
If by hellhound you mean Cerberus and by sickening you mean having your body slowly consumed by flesh eating bacteria.
Tal Bernard Mainz |
Your AC won't help against the luscious lips of Krona - touch AC FTW!!!
At least I have a decent fort save. I don't think the audience would approve of me retching on stage. Also does a tower shield granting me total cover help that at all?
Castor the rat |
OK.. so I just need some clarification. Reading through the play I understand the acts and the tortures each one hold. What I want to know is if we know how the tortures will be done on stage?
We do not know but guesses can be made.
Trial one; Simple torture. I suspect tilted racks and Saint Andrew's Cross. Good visual appeal for the masses. Probably not a wheel as we need to walk after but perhaps
Trial two: The flukes will no doubt be some kind of burrowing worm or insect. My AD&D heart holds fond memories of rot grubs but that may be too lethal.
Trial three: This one has me puzzled. A big monster eating us is well within the possable but that would be boring to the audiance. They do not get to see our death throws and all. Maybe if it had a transparent stomach?
Trial four: Frankly I haven't paid too much attention to the later trials. Given my hit point total I expect to to be slightly dead by this point. But reading the script I guess this trial will be some con drain followed by a fight with some low to mid level devils. Perhaps they will share some of our major strengths. Hexes for mine High AC for Tal's etc.
Trial five:"The companions fight off a legion of devils." 'nuff said
Trial six: No clue on this one. It sems a tad anticlimatic but berhaps the sight of Thesing being dragged to hell makes up for it.
That said I am likely wrong on important points but they mostly will not matter as Tal and Caldazar are the only ones likely to make it to the fifth trial.
Tal Bernard Mainz |
I think if thesing can he will do his worst to Tal after the lunch is over. We'll see how that goes.
As far as the trials go...Well if we all make it to the fourth trial I can try and just stand up front and take the beating while you guys work your magic. Same for the 5th trial as well I suppose.
Petronicus Crispin |
Well transparent stomach would mean that we would have to deal with stomach acid and we are supposed to escape as they do in the script. Not sure how that is going to be but I would bet we have to deal with acid in some manner or other.
I think I need to make a shopping list of some spells/scrolls that may help. I know I will need to learn bear's endurance at a minimum and maybe try to see if I can get some of the 'mass' versions of the spells.
Pollux |
I just realized that trial four is where they eat an egg that births a doppelganger that they fight.
I am clueless as to how this will be presented. Perhaps we eat something that will make us sick. Maybe protection from poison would be appropriate?
My default raesoning is to assume that the script states what will happen. I expect us to eat something that then crawls up our gullets and attacks. It is visually impressive for the audience and would only take a modified summon monster type magic 'egg' to do it mechanically.
As far as getting gear for the trials I think our first purchase must be a full wand of CLW. We need the healing and about half the party can use it w/o worring about UMD. Pollux has 300gp that he can toss in the kitty in case somone is a tad short.
Tal Bernard Mainz |
Since I foolishly indicated that you guys split the share last time I spent almost all of my original alotment before we even started. That being said, I do have 100gp to put towards the wand.
Tark...Is it possible to find wands that are not full. Just wondering if we can't get the 750 we need. Extra healing is always a bonus. Besides if we have a healing wand, that frees up the casters for spells that might actually make a difference. Resist Energy: Acid, Eagles Splendor, ?Magic Weapon?, lessor restorations?
Castor the rat |
I don't think we need to concern ourselves any further with the wand.
Nice trap by Thesing and the Diva. I wonder how much this meal will cost conpared to how much Robahl will have to pay to get us out of the pokey. Pity this is the exact question the Tik-man could have answered.
Caldazar |
I think Calseinica only bailed out Tal.
Caldazar has some coin that can be used if anyone is really skint... he'd stump it up to get out of the limelight and into a place where a more suitable comeuppance could be planned.
Perhaps we corner Thesing in his dressing room and extort the money out of him.... or we turn him into a gelding... either is good... Yes, I realize this is hypocritical in retrospect with the sage council he offered Tal...
Tal Bernard Mainz |
Nah Tal is up for it. Actually, the sneakiest one of us should just enter his room and take it when he is not there. Tal will definitely vote to be the distraction. Perhaps involve robahl with the retelling of the dinner, complete with the trip of Thesing.
Tal Bernard Mainz |
Thus the large axe he always carries with him.
Sunderstone |
I'm still here lurking. I don't have much to add to the groups luncheon with Thesing. Just letting you know I didn't vanish. :)
To the GM from splitting away from the group but Meraxilar is the lower profile type both as a follower of Rovagug in Cheliax (which would get me killed by the Rack), and a former scion of a destroyed/culled house. I don't mind reading along, so don't anyone rush on my account. The Luncheon was cool. :)
Tal Bernard Mainz |
Just making sure of the timeline right now. The luncheon was the during the same day as Tal's supper. Just want to make sure so I don't reference one at the wrong time. I am pretty sure, but it is late and I am not thinking straight.
Castor the rat |
Hey TarkXT. Hope you don't mind a bit of advertising here
To nobles and rebels: I would like to announce a couple of openings in a Carrion Crown campaign that I am in. We are just starting out, you would be coming in at 500xp where the three players have just made second. I know this sounds a bit of a raw deal but you catch up quite rapidly. I think the GM just prefers organically leveled as opposed to characters made to the level.
In any case please see the Recruitment, Gameplay, and Discussion threads. Thank you for your time.
We now return you to the spite and eye-gouging in progress....


text:
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- Filed Under
The Green Bay Packers have begun demolishing about a dozen houses south of Lambeau Field.
Most of the houses are on Barberry Lane, directly south of Valley View Road. A few are on Valley View Road and South Ridge Road. The Packers plan to use the land for grass parking this season. Long-term plans have not been announced.
The project will create about 450 parking spaces. The paved parking at the stadium will be unchanged when the team finishes its current construction, but the team did add 7,000 seats to the stadium before the 2013-14 season. ...


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UnSHIELDed: "Agents of SHIELD" Evolves With the Marvel Cinematic Universe
Film, TV
Showing results 10-49 of 122
"Wonder Woman" artist Cliff Chiang stopped by the CBR Tiki Room at WonderCon to discuss the critically acclaimed take on the Amazon.
The first issue of DC Comics' "Futures End" weekly series is "an enjoyable debut that's helped along by a strong artist."
Check out a preview of DC Comics' time traveling "Futures End" #1 featuring Terry McGinnis as the Batman of 5 years from now, on sale May 7!
Brian Azzarello & Dan Jurgens, half the writing team of DC's new weekly series, talk the challenges of telling a story that drags the DCU forward in time.
DC's New 52 continues to stun readers with "Futures End." The apocalyptic tale may just shatter the DC Universe when it begins on Free Comic Book Day.
DC Comics opened up C2E2 with a guided tour of the New 52 featuring Scott Snyder, Brian Azzarello, Charles Soule and more as they tease the arcs of DC's three weekly series and a brand-new Steel.
Diana takes command of a deadly army in DC Comics' "Wonder Woman" #30 by Brian Azzarello and guest artist Goran Sudzuka, on sale April 16.
"Batman Beyond 2.0" writer Kyle Higgins and "Futures End" writer Brian Azzarello confirm Terry McGinnis' imminent arrival in New 52 continuity.
CBR spoke exclusively with Brian Azzarello, Keith Giffen, Dan Jurgens and Jeff Lemire in their first roundtable interview on "The New 52: Futures End."
DC Comics jumps ahead five years in May with the weekly "The New 52: Futures End." The title debuts with a Zero issue on Free Comic Book Day.
Brian Azzarello and ACO put the spotlight on the First Born in "Wonder Woman" #23.2, in "one of the real winners of Villains Month" that "clicks in with the rest of the series perfectly."
Tim reconsiders "Spaceman," the mostly-ignored sci-fi miniseries from the "100 Bullets" team of Brian Azzarello and Eduardo Risso, and finds a comic that is not at all what it first seems to be.
Brian Azzarello discusses the breakout supervillain from his and Cliff Chiang's "Wonder Woman," Diana's eldest brother First Born, and what's to come following the shocking events of the most recent issue.
Greg McElhatton gives "Wonder Woman" #23 by Brian Azzarello and Cliff Chiang 4 stars, saying, "the series as a whole has walked to the beat of its own drum, and this is no exception."
DC Comics has released a preview of "Wonder Woman" #23 by Brian Azzarello & Cliff Chiang. While Wonder Woman battles the bloodthirsty First Born, War lets loose his secret army August 21.
Doug Zawisza gives Brian Azzarello & Cliff Chiang's "Wonder Woman" #22 4 stars, saying the creative team continues to add "depth and dimension to the characters surrounding and opposing Wonder Woman."
"Wonder Woman" and "Brother Lono" writer Brian Azzarello spoke with CBR about revisiting the popular "100 Bullets" character and the clash of New and Greek gods in DC Comics' New 52.
Vertigo has released a preview of Brian Azzarello and Eduardo Risso's "100 Bullets: Brother Lono" #1, which takes place four years after the acclaimed series finale. The most savage Minuteman of all returns June 19.
DC Comics has released a first look at Eduardo Risso's variant cover for "100 Bullets: Brother Lono" #1 -- the first piece of art marking the artist's long-awaited return to the "100 Bullets" series.
Comparing "Brother Lono" to "Laverne & Shirley," Eisner Award winner Brian Azzarello wants everyone to know that his and Eduardo Risso's new Vertigo series is a spinoff not a sequel.
Charles Soule, Peter Tomasi, Sterling Gates and more writers and artists join top editors Bob Harras and Bobbie Chase at C2E2 to discuss the latest developments in DC Comics' New 52.
A Chicago mash-up of DC Comics and Vertigo talent collide at DC's All Access panel featuring Brian Azzarello, Kyle Higgins, Art N Frano and more discuss their series and the future of DC in Chicago.
DC Comics has released a preview of "Wonder Woman" #19 by Brian Azzarello, Goran Sudzuka and Tony Akins. Wonder Woman discovers the one way to stop Orion April 17.
Brian Azzarello and Cliff Chiang continue to explore Diana's family tree in this exclusive preview of "Wonder Woman" #18, featuring art by Goran Sudzuka and Tony Akins. The issue goes on sale March 20.
DC Comics has provided CBR with an exclusive first look at Ivan Reis and Joe Prado's variant cover for "Before Watchmen: Rorschach" #4 by Brian Azzarello and Lee Bermejo. The concluding issue hits February 13.
With Vertigo Executive Editor Karen Berger departing her position and the cancellation of "Hellblazer," CBR looks at the history of the acclaimed DC Comics' imprint and presents our picks for its top ten series.
Disney calls $5.5 billion lawsuit over Marvel characters "completely frivolous"! Final print edition of "The Dandy" sells out! Jonathan Hickman talks "Avengers"! Brian Azzarello talks "Before Watchmen: Comedian"! Plus much more!
Artist Cliff Chiang spoke with CBR about his and Brian Azzarello's first year on "Wonder Woman," the thought process behind his Greek pantheon designs and his take on the Fourth World's Orion.
Original "Calvin and Hobbes" art fetches $203,150 at auction! Best-of-the-year lists from The New York Times and The Washington Post! Brian Azzarello talks "Wonder Woman"! Howard Cruse on "The Other Side of Howard Cruse"! Plus more!
Writer Brian Azzarello spoke with CBR about creating the "Watchmen" prequels, the inclusion of the New Gods in "Wonder Woman" and the challenge of developing stories as a fan.
Greg McElhatton gives Brian Azzarello and Tony Akins' "Wonder Woman" #13 4 stars, calling the issue "a great example of how well a reboot of a company's line of comics can work with the right creators."
Brian Azzarello, Lee Bermejo, Amanda Conner, and Bill Sienkiewicz took the stage at New York Comic Con to discuss their "Before Watchmen" series, with especially candid commentary from the "Comedian" writer.
At the "From Concept To Page" panel at NYCC, DC Comics revealed creative secrets, from the pitch, to character designs, page layouts and more with over 40 images from Brian Azzarello and Cliff Chiang's Wonder Woman revamp.
DC Comics has provided CBR News with an exclusive first look at artist Brian Stelfreeze's variant cover for "Before Watchmen: Comedian" #4. The issue, by Brian Azzarello and J.G. Jones, hits stores October 31.
Ryan K. Lindsay gives "Wonder Woman" #0 4 stars, calling the throwback issue by Brian Azzarello and Cliff Chiang "one of the New 52's strongest assets yet to lure in new readers and demonstrate the strength of comics."
DC Comics hosted a lively discussion about "Before Watchmen" at Fan Expo, where they announced a new title and a new inker for "Nite Owl."
Brian Azzarello lead a panel at Fan Expo with a focus on crime fiction that progressed into topics including his take on Rorschach, the passing of Joe Kubert, and future writing plans.
"Wonder Woman" writer Brian Azzarello discusses his first year writing DC Comics' Amazon princess, the decision to avoid crossing over with other New 52 titles, the debut of a New God and declaring Diana's age.
CSBG's Chad Nevett and Brian Cronin continue their series of joint-reviews for the Before Watchmen comics with a look at Brian Azzarello and Lee Bermejo's' "Rorschach" #1!
As the current incarnation of "Wonder Woman" finishes it's first year, Greg McElhatton gives issue #12 4.5 stars, calling Brian Azzarello and Cliff Chiang's take on the Amazonian princess "a must-read."
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bree_violet 1
Originally uploaded by HYPNOX Photography.
« Technical Difficulties | Home | Belly after 6 babies! (Anonymous) »
This is one of my favorite photos. So lovely.
what a gorgeous photo!
Hey, I know you! You're on my Myspace friends. ;)
This pic is lovely, as are all your others. You are such a beautiful mama.
That is just stunning!


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What to do if a shroud or stay breaks
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Morgan 33 O.I. Perryville
Join Date: Dec 2010
Location: Maryland
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Re: What to do if a shroud or stay breaks
I had a forestay part right at the top of the deck turnbuckle. This occurred just a few seconds after the jib was furled on my 27 Catalina. The wind was woofing at about 20 at the time, and we were in a running mode with fairly heavy, following seas. The entire roller furling system fell into Chesapeake Bay, almost in slow motion and the only thing that saved it from sinking to the murky depths were the jib sheets, which had just been cleated off. The mast was saved from damage by quickly attaching the old jib halyard to a bow cleat, then winching the halyard tight with the jib winch. The main had already been lowered prior to the forestay failure.
The boat was motored 20 miles back to Perryville, MD at the head of the bay, and the following day it was motored across the bay to Tidewater Yacht Basin at Havre de Grace where repairs were quickly made. Despite some nasty bends in the aluminum sheaves of the Alado Roller Furling System, I was able to straighten them using a rubber mallet and a couple blocks of wood. Only a single sheave was damaged beyond repair, which I found amazing.
Good topic,
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Micro- and nanofluidic devices for environmental and biomedical applications
Gardeniers, Han and Berg, Albert van den (2004) Micro- and nanofluidic devices for environmental and biomedical applications. International Journal of Environmental Analytical Chemistry, 84 (11). pp. 809-819. ISSN 0306-7319
Restricted to UT campus only : Request a copy 196kB |
Abstract: | During the last decade, an increasing amount of pocket-size chemistry equipment based on the so-called 'lab-on-a-chip'approach has become available. Besides the popular application in the analysis of biological macromolecules, such chips in combination with portable electronic equipment are applicable in, for example, 'point-of-care' ion analysis of body fluids, forensics, identification of explosives, tracking of pollution in environmental or waste waters, monitoring nutrients in agricultural or horticultural water, controlling quality in food production or process control in chemical industry. This paper discusses the development of a number of demonstrator chips and microsystems with applications in some of these fields. In particular, an integrated microsystem for flow injection analysis of ammonia in surface waters, a hydrodynamic chromatography chip for the analysis of particles and polymer molecules and a chip for ion analysis in blood are discussed in detail. The last chip may also find applications in environmental analysis. |
Item Type: | Article |
Copyright: | © 2004 Taylor & Francis |
Faculty: | Science and Technology (TNW) Electrical Engineering, Mathematics and Computer Science (EEMCS) |
Research Group: | |
Link to this item: | http://purl.utwente.nl/publications/47990 |
Official URL: | http://dx.doi.org/10.1080/03067310310001626678 |
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Metis ID: 219077


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Home About us News Contact us | ||||||
John Libbey Publishing | ||||||
Big Picture, Small Screen The Relations Between Film and Television
Big Picture, Small Screen The Relations Between Film and TelevisionEdited by: John Hill, Martin McLoone Publication date: 1996 Total pages: 278 ISBN: 1 86020 005 2 Price: £ 22.50 Description
Film and television are now closer together than ever
before. While television may once have been regarded as the enemy of
cinema, it has since become a major source of funding and revenue for
the film industry. In Europe, and especially in Britain, television has
more or less become the film industry.
BiographyJohn Hill and Martin McLoone both teach Media Studies at the University of Ulster.


text:
Running Rigging Plan
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Telstar 28
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8:1 is probably overkill on almost everything. You're on a 34' boat...
I also notice that you're using single line reefing. I would highly recommend you use double-line reefing, as it gives you much more control over the reefed sail's shape IMHO and is faster and easier to use.
I'd also agree that having line clutches on the pole life and downhaul are a bad idea.
Finally, you'll probably want to angle the line organizers a bit more, so that the two or three lines are running very close to each other, rather than spread out the way you have them on the drawing. This is to minimize the deck area they take up and help reduce the tripping hazard.
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Telstar 28
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You know what the first rule of sailing is? ...Love. You can learn all the math in the 'verse, but you take
a boat to the sea you don't love, she'll shake you off just as sure as the turning of the worlds. Love keeps
her going when she oughta fall down, tells you she's hurting 'fore she keens. Makes her a home.
Cpt. Mal Reynolds, Serenity
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KJV Thinline Bible Compact, Italian Duo-Tone, Midnight Blue/Moss Green
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A quarter mile section of the Blacksmith Flat Road in the Eldorado National Forest, near the Ralston Powerhouse, will be closed from Nov. 4 to approximately Dec. 13.
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Work crews will be removing and stabilizing rocks above the road. This route is located within the Georgetown Ranger District and is also known as Forest Route 23 and forest road number 14N25. The road will remain closed until the work is complete.


text:
45389-002: Second Road Network Development Investment Program - Tranche 1
Project Data Sheet (PDS): Overview
Project 1 will fund two components: i) Infrastructure Development Component - construction of an approximately 30 km section of the new motorway between Masalli and Jalilabad of the Masalli-Shorsulu road; and ii) Project Implementation Support Components - project implementation support to ARS for construction supervision and program management covering planning, procurement, project preparation and implementation. Read More
Country |
Azerbaijan |
Project Number | 45389-002 |
Type or Modality of Assistance |
Loan |
Financing | Public sector (Sovereign) |
Status | Approved |
Approval Number |
Loan No. 2921 |
Approval Date | 25 Oct 2012 |
ADB Financing ($ thousand) | 250,000 |
Geographical Location | Masalli-Shorsulu Road |
Sector |
Transport |
Subsector | Road transport (non-urban) |
Strategic Agendas |
Inclusive economic growth (IEG) Regional integration (RCI) |
Drivers of Change |
Gender equity and mainstreaming (GEM) Private sector development (PSD) |
Gender Equity and Mainstreaming Categories | Category 3: Some gender elements (SGE) |
Safeguard Categories |
Environment: A Resettlement: A Indigenous People: C |
Related Projects
Project Data Sheets (PDS) contain summary information on the project or program. Because the PDS is a work in progress, some information may not be included in its initial version but will be added as it becomes available. Information about proposed projects is tentative and indicative.
The Public Communications Policy (PCP) recognizes that transparency and accountability are essential to development effectiveness. It establishes the disclosure requirements for documents and information ADB produces or requires to be produced.
The Accountability Mechanism provides a forum where people adversely affected by ADB-assisted projects can voice and seek solutions to their problems and report alleged noncompliance of ADB's operational policies and procedures.
In preparing any country program or strategy, financing any project, or by making any designation of, or reference to, a particular territory or geographic area in this document, the Asian Development Bank does not intend to make any judgments as to the legal or other status of any territory or area.
View the latest procurement notices for Goods, Works and Related Services, or Consulting Services.


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eBook (PDF), 287 Pages
Download immediately.
A son of a forest dwelling people, Yhalen knows little of the world outside the ancestral forest, until he is captured by a band of ogres on a slave-taking mission. Only grim tales of the barbaric giants had reached the forest, but Yhalen soon learns that even the darkest fireside story only hinted at the brutality of these Northern warriors. He discovers the meaning of true fear at their hands, and only the awakening of ancient magic saves him from destruction.
Surviving ogre viciousness, he finds himself given to Bloodraven, the half ogre, half human war leader as a slave. Yhalen, refusing to bend, soon pays the price for offending prickly ogre pride.
But Bloodraven is no mindless, violent ogrish beast. Bloodraven has an agenda and Yhalen finds himself drawn in the wake into human and ogre politics, into bloodshed and cruelty and into the forbidden magic that is damnation in the eyes of his own people, but which might mean the difference between death and salvation.
People Reviewed This Product
Oct 10, 2010
Sep 24, 2010Pam has been one of my favorite authors for more years than either of us want to count... And Bloodraven is my favorite of her novels. Admittedly, I am most definitely NOT squeamish and I throughly enjoy the struggles and brutality wrought upon her beautiful young hero. Yhalen proves to be strong and resourceful - as well as magic. He and Bloodraven develop an intricate and fascinating relationship as the book unfolds.
Aug 6, 2010
Jun 8, 2010One of the best fantasy novels I've read. Truly excellent work. Not for the faint of heart.
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Product Details
- Copyright
- Standard Copyright (Standard Copyright License)
- Publisher
- Pam Nunnally
- Published
- September 30, 2011
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- English
- Pages
- 287
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COX-2 inhibitor
COX-2 selective inhibitor is a form of non-steroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX-2 reduces the risk of peptic ulceration, and is the main feature of celecoxib, rofecoxib and other members of this drug class. After several COX-2 inhibiting drugs were approved for marketing, data from clinical trials revealed that COX-2 inhibitors caused a significant increase in heart attacks and strokes, with some drugs in the class having worse risks than others. Rofecoxib (commonly known as Vioxx) was taken off the market in 2004 because of these concerns and celecoxib and traditional NSAIDs received boxed warnings on their labels.
Medical uses[edit]
Some COX-2 inhibitors are used in a single dose to treat pain after surgery.[1][2]
Etoricoxib appears as good as if not better than other pain medications.[3] Celecoxib appears to be about as useful as ibuprofen.[4]
Adverse effects[edit]
Analysis of clinical trial data revealed that there was a significant increase in the rate of vascular events with COX-2 inhibitors compared with placebo; "vascular events" are non-fatal myocardial infarction (MI) or heart attack, non-fatal stroke, and death from a vascular event such as MI or stroke.[5][6] These results led Merck to voluntarily withdraw (Rofecoxib) from the market in September 2004 and to regulatory authorities imposing a boxed warning on the label of celecoxib.[5] Traditional NSAIDs were also found to have cardiovascular risks, leading to similar boxed warnings.[5]
The cause of the cardiovascular problems became, and remains, a subject of intensive research.[7] As of 2012 results have been converging on the hypothesis that the adverse cardiovascular effects are most likely due to inhibition of COX-2 in blood vessels, which leads to a decrease in the production of prostacyclin in them. Prostacyclin usually prevents platelet aggregation and vasoconstriction, so its inhibition can lead to excess clot formation and higher blood pressure.[7]
Combination drugs[edit]
This section does not cite any references or sources. (April 2014) |
A model comparing the theoretical relative frequency of gastrointestinal adverse effects and cost effectiveness of celecoxib, nonspecific NSAIDs alone, NSAIDs plus a proton pump inhibitor, NSAIDs plus an H2 receptor antagonist, NSAIDs plus misoprostol, and diclofenac/misoprostol, found the lowest probability of adverse gastrointestinal events for celecoxib, followed by NSAIDs plus a proton pump inhibitor, NSAIDs plus an H2 receptor antagonist, NSAID plus misoprostol, diclofenac/misoprostol, and NSAID alone. In total cost, including drug plus treatment of any gastrointestinal effects, the lowest cost treatment was celecoxib, followed by NSAIDs alone and diclofenac/misoprostol, with the other NSAID plus gastrointestinal protection regimens being much more costly. Similarly, a model of cost effectiveness of rofecoxib and celecoxib compared to high-dose acetaminophen or ibuprofen, with and without misoprostol, in patients with osteoarthritis of the knee found that acetaminophen had the lowest cost for average patients. For those not responding to paracetamol, ibuprofen was the most cost effective treatment by a large margin, but for those who did not respond to acetaminophen and had a high risk of gastrointestinal damage, rofecoxib was the most cost effective treatment.
The adverse effects of COX 2 inhibitors are the subject of extensive scientific debate. Several studies have pointed to a subtle increase in the risk of myocardial infarction, hypertension and also potential gastrointestinal complications. The following examples illustrate some of these risks, however (as with all medications) a consultation with a medical professional should be sought to discuss these issues before a firm opinion regarding their safety is established.
A French study of osteoarthritis patients over 65 years of age determined that, compared to Celebrex (200 mg once daily), patients taking Vioxx (25 mg once daily) suffered a two-fold increase in clinically significant edema and 60% more frequent increases in systolic blood pressure greater than 20 mmHg, as early as the second week of treatment. This has significant implications, since it has been estimated that every 2 mmHg increase in blood pressure raises the risk of stroke by two thirds and the risk of myocardial infarction by one third, suggesting that Celebrex may be a better choice for hypertensive patients or those at risk for edema. In addition, COX-2 inhibitors lack some of the platelet inhibiting properties of aspirin and other nonspecific NSAIDs and may, directly or indirectly, lead to increased risk of thrombosis, particularly in high risk patients where low dose aspirin therapy is warranted. On the other hand, this property makes them a better choice for perisurgical pain management, where inhibition of blood clotting would be problematic.
There are other differences between Celebrex and Vioxx that influence prescribing practices. Patients with known sensitivity to sulfa drugs are likely to be sensitive to Celebrex as well, due to similarity in structure. Vioxx has a more rapid onset and is approved for acute pain as well as osteoarthritis, while Celebrex is approved for rheumatoid arthritis as well as osteoarthritis.
COX-2 appears to be related to cancers and abnormal growths in the intestinal tract. COX inhibitors have been shown to reduce the occurrence of cancers and pre-cancerous growths. The National Cancer Institute has done some studies on COX-2 and cancer.[8] And the FDA has approved Celebrex for treatment of familial adenomatous polyposis (FAP) [2]. COX-2 inhibitors are currently being studied in breast cancer[9] and appear to be beneficial.[10]
Neuropsychiatric disorders[edit]
COX-2 inhibitors have been found to be effective in suppressing inflammatory neurodegenerative pathways in mental illness, with beneficial results in trials for major depressive disorder as well as schizophrenia.[11]
Other targets[edit]
The inhibition of COX-2 is paramount for the anti-inflammatory and analgesic function of the selective COX-2 inhibitor celecoxib. However, with regards to this drug's promise for the therapy of advanced cancers, it is unclear whether the inhibition of COX-2 plays a dominant role, and this has become a controversial and intensely researched issue. In recent years, several additional intracellular components (besides COX-2) were discovered that appear to be important for mediating the anticancer effects of celecoxib in the absence of COX-2.[12] Moreover, a recent study with various malignant tumor cells showed that celecoxib could inhibit the growth of these cells, even though some of these cancer cells didn't even contain COX-2.[13]
Additional support for the idea that other targets besides COX-2 are important for celecoxib's anticancer effects has come from studies with chemically modified versions of celecoxib. Several dozen analogs of celecoxib were generated with small alterations in their chemical structures.[14] Some of these analogs retained COX-2 inhibitory activity, whereas many others didn't. However, when the ability of all these compounds to kill tumor cells in cell culture was investigated, it turned out that the antitumor potency did not at all depend on whether or not the respective compound could inhibit COX-2, showing that inhibition of COX-2 was not required for the anticancer effects.[14][15] One of these compounds, 2,5-dimethyl-celecoxib, which entirely lacks the ability to inhibit COX-2, actually turned out to display stronger anticancer activity than celecoxib itself [16] and this anticancer effect could also be verified in highly drug-resistant tumor cells[17] and in various animal tumor models.[18][19]
Research history[edit]
The COX-2 enzyme was discovered in 1988 by Daniel Simmons, a Brigham Young University researcher.[20] The mouse COX-2 gene was cloned by UCLA scientist Dr. Harvey Herschman, a finding published in 1991.[21]
The basic research leading to the discovery of COX-2 inhibitors has been the subject of at least two lawsuits. Brigham Young University has sued Pfizer, alleging breach of contract from relations BYU had with the company at the time of Dr. Simmons work.[22][23] A settlement was reached in April 2012 in which Pfizer agreed to pay $450 million.[24][25] The other litigation is based on United States Pat. No. 6,048,850[26] owned by University of Rochester, which claimed a method to treat pain without causing gastro-intestinal distress by selectively inhibiting COX-2. When the patent issued, the university sued Searle (later Pfizer) in a case called, University of Rochester v. G.D. Searle & Co., 358 F.3d 916 (Fed. Cir. 2004). The court ruled in favor of Searle in 2004, holding in essence that the university had claimed a method requiring, yet provided no written description of, a compound that could inhibit COX-2 and therefore the patent was invalid.[27][28]
In the course of the search for a specific inhibitor of the negative effects of prostaglandins which spared the positive effects, it was discovered that prostaglandins could indeed be separated into two general classes which could loosely be regarded as "good prostaglandins" and "bad prostaglandins", according to the structure of a particular enzyme involved in their biosynthesis, cyclooxygenase.
Prostaglandins whose synthesis involves the cyclooxygenase-I enzyme, or COX-1, are responsible for maintenance and protection of the gastrointestinal tract, while prostaglandins whose synthesis involves the cyclooxygenase-II enzyme, or COX-2, are responsible for inflammation and pain.
The existing non-steroidal anti-inflammatory drugs (NSAIDs) differ in their relative specificities for COX-2 and COX-1; while aspirin and ibuprofen inhibit COX-2 and COX-1 enzymes, other NSAIDs appear to have partial COX-2 specificity, particularly meloxicam (Mobic). Aspirin is ≈170-fold more potent in inhibiting COX-1 than COX-2.[29] Studies of meloxicam 7.5 mg per day for 23 days find a level of gastric injury similar to that of a placebo, and for meloxicam 15 mg per day a level of injury lower than that of other NSAIDs; however, in clinical practice meloxicam can still cause some ulcer complications.
Many COX-2-specific inhibitors have been removed from the U.S. market. As of December 2011, only Celebrex (generic name is celecoxib) is still available for purchase.
Valdecoxib and rofecoxib are about 300 times more potent at inhibiting COX-2, than COX-1, suggesting the possibility of relief from pain and inflammation, without gastrointestinal irritation, and promising to be a boon for those who had experienced such adverse effects previously or had comorbidities that could lead to such complications. Celecoxib is approximately 30 times more potent at inhibiting COX-2 than COX-1, with etoricoxib being 106 times more potent. Also, Tribulus terrestris was shown to have strong inhibitory activity on COX-2.[30]
Research fraud[edit]
Between 1996 and 2009, anesthesiologist Scott Reuben conducted clinical research on the use of COX-2 inhibitors, often in combination with gabapentin or pregabalin, for the prevention and treatment of post-surgical pain, which was found in 2009 to have been faked. Reuben pled guilty, paid fines and served six months in jail, and lost his medical license.[31] A 2009 review of systematic review articles used in evidence-based medicine found that while some reviews were no longer valid when the Reuben studies were removed, the conclusions in the majority of them remained unchanged.[32] The review found that the key Reuben claims that needed to be re-examined were "the absence of detrimental effects of coxibs on bone healing after spine surgery, the beneficial long-term outcome after preemptive administration of coxibs including an allegedly decreased incidence of chronic pain after surgery, and the analgesic efficacy of ketorolac or clonidine when added to local anesthetics for intravenous regional anesthesia."[32]
Early COX-2-inhibiting drugs[edit]
This section does not cite any references or sources. (April 2014) |
Celebrex (and other brand names for celecoxib) was introduced in 1999 and rapidly became the most frequently prescribed new drug in the United States. By October 2000, its US sales exceeded 100 million prescriptions per year for $3 billion, and was still rising. Sales of Celebrex alone reached $3.1 billion in 2001. A Spanish study found that between January 2000 and June 2001, 7% of NSAID prescriptions and 29% of NSAID expenditures were for COX-2 inhibitors. Over the period of the study, COX-2 inhibitors rose from 10.03% of total NSAIDs prescribed by specialty physicians to 29.79%, and from 1.52% to 10.78% of NSAIDs prescribed by primary care physicians (98.23% of NSAIDs and 94.61% of COX-2 inhibitors were prescribed by primary care physicians). For specialty physicians, rofecoxib and celecoxib were third and fifth most frequently prescribed NSAIDs but first and second in cost, respectively; for primary-care physicians they were ninth and twelfth most frequently prescribed NSAIDs and first and fourth in cost.
The cause of the rapid widespread acceptance of Celebrex and Vioxx by physicians was the publication of two large trials, the Celecoxib Long-term Arthritis Safety Study [33] CLASS study in JAMA, and the Vioxx Gastrointestinal Outcomes Research[34] VIGOR study in the New England Journal of Medicine. Both publications concluded that COX-2 specific NSAIDs were associated with significantly fewer adverse gastrointestinal effects. In the CLASS trial comparing Celebrex 800 mg/day to ibuprofen 2400 mg/day and diclofenac 150 mg/day for osteoarthritis or rheumatoid arthritis for six months, Celebrex was significantly associated with fewer upper gastrointestinal complications (0.44% vs. 1.27%, P=0.04), with no significant difference in incidence of cardiovascular events in patients not taking aspirin for cardiovascular prophylaxis. In the VIGOR trial testing Vioxx 50 mg/day versus naproxen for rheumatoid arthritis, Vioxx reduced the risk of symptomatic ulcers and clinical upper gastrointestinal events (perforations, obstructions and bleeding) by 54%, to 1.4% from 3%, the risk of complicated upper gastrointestinal events (complicated perforations, obstructions and bleeding in the upper gastrointestinal tract) by 57%, and the risk of bleeding from anywhere in the gastrointestinal tract by 62%. An enormous marketing effort capitalized on these publications; Vioxx was the most heavily advertised prescription drug in 2000, and Celebrex the seventh, according to IMS Health.
Future of COX-2 inhibitors -Neuroblastomas[edit]
Recent studies have shown that small tumors of the sympathetic nervous system (neuroblastoma) have abnormal levels of COX-2 expressed.[35] These studies report that overexpression of the COX-2 enzyme has an adverse effect on the tumor suppressor, p53. p53 is an apoptosis transcription factor normally found in the cytosol. When cellular DNA is damaged beyond repair, p53 is transported to the nucleus where it promotes p53 mediated apoptosis.[36] Two of the metabolites of COX-2, prostaglandin A2 (PGA2) and A1 (PGA1), when present in high quantities bind to p53 in the cytosol and inhibit its ability to cross into the nucleus. This essentially sequesters p53 in the cytosol and prevents apoptosis.[36] Coxibs such as Celebrex (celecoxib), by selectively inhibiting the overexpressed COX-2, allow p53 to work properly. Functional p53 allows DNA damaged neuroblastoma cells to commit suicide through apoptosis, halting tumor growth.
COX-2 up-regulation has also been linked to the phosphorylation and activation of the E3 ubiquitin ligase HDM2, a protein that mediates p53 ligation and tagged destruction, through ubiquitination.[36] The mechanism for this neuroblastoma HDM2 hyperactivity is unknown. Studies have shown that COX-2 inhibitors block the phosphorylation of HDM2 preventing its activation. In vitro, the use of COX-2 inhibitors lowers the level of active HDM2 found in neuroblastoma cells. The exact process of how COX-2 inhibitors block HDM2 phosphorylation is unknown, but this mediated reduction in active HDM2 concentration level restores the cellular p53 levels. After treatment with a COX-2 inhibitor, the restored p53 function allows DNA damaged neuroblastoma cells to commit suicide through apoptosis reducing the size of growth of the tumor.[36]
See also[edit]
- ^ Tirunagari, Shravan Kumar; Derry, Sheena; Moore, R Andrew; McQuay, Henry J; Moore, Maura (2009). "Single dose oral etodolac for acute postoperative pain in adults". Reviews. doi:10.1002/14651858.CD007357.pub2.
- ^ Bulley, Simon; Derry, Sheena; Moore, R Andrew; McQuay, Henry J; Derry, Sheena (2009). "Single dose oral rofecoxib for acute postoperative pain in adults". Protocols. doi:10.1002/14651858.CD004604.pub3.
- ^ Clarke, R; Derry, S; Moore, RA (May 8, 2014). "Single dose oral etoricoxib for acute postoperative pain in adults.". The Cochrane database of systematic reviews 5: CD004309. doi:10.1002/14651858.CD004309.pub4. PMID 24809657.
- ^ Derry, S; Moore, RA (Oct 22, 2013). "Single dose oral celecoxib for acute postoperative pain in adults.". The Cochrane database of systematic reviews 10: CD004233. doi:10.1002/14651858.CD004233.pub4. PMID 24150982.
- ^ a b c Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA (March 2007). "Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association". Circulation 115 (12): 1634–42. doi:10.1161/CIRCULATIONAHA.106.181424. PMID 17325246.
- ^ Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C (June 2006). "Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials". BMJ 332 (7553): 1302–8. doi:10.1136/bmj.332.7553.1302. PMC 1473048. PMID 16740558.
- ^ a b Cannon CP, Cannon PJ (June 2012). "Physiology. COX-2 inhibitors and cardiovascular risk". Science 336 (6087): 1386–7. doi:10.1126/science.1224398. PMID 22700906.
- ^ "COX-2 Inhibitors and Cancer". Fact Sheet. United States National Cancer Institute.
- ^ Chow LW, Loo WT, Toi M (October 2005). "Current directions for COX-2 inhibition in breast cancer". Biomed. Pharmacother. 59 Suppl 2: S281–4. doi:10.1016/S0753-3322(05)80046-0. PMID 16507393.
- ^ Farooqui M, Li Y, Rogers T et al. (December 2007). "COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia". Br. J. Cancer 97 (11): 1523–31. doi:10.1038/sj.bjc.6604057. PMC 2360252. PMID 17971769.
- ^ Müller N (January 2010). "COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence". Curr Opin Investig Drugs 11 (1): 31–42. PMID 20047157.
- ^ Schönthal AH (December 2007). "Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy". Br. J. Cancer 97 (11): 1465–8. doi:10.1038/sj.bjc.6604049. PMC 2360267. PMID 17955049.
- ^ Chuang HC, Kardosh A, Gaffney KJ, Petasis NA, Schönthal AH (2008). "COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro". Mol. Cancer 7: 38. doi:10.1186/1476-4598-7-38. PMC 2396175. PMID 18485224.
- ^ a b Zhu J, Song X, Lin HP et al. (December 2002). "Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents". J. Natl. Cancer Inst. 94 (23): 1745–57. doi:10.1093/jnci/94.23.1745. PMID 12464646.
- ^ Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA (February 2008). "Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs". Expert Opin Investig Drugs 17 (2): 197–208. doi:10.1517/13543722.214.171.124. PMID 18230053.
- ^ Schönthal AH (2006). "Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy". Neurosurg Focus 20 (4): E21. doi:10.3171/foc.2006.20.4.14. PMID 16709027.
- ^ Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH (December 2005). "Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib". Blood 106 (13): 4330–8. doi:10.1182/blood-2005-07-2819. PMID 16123214.
- ^ Pyrko P, Kardosh A, Liu YT, Soriano N, Xiong W, Chow RH, Uddin J, Petasis NA, Mircheff AK, Farley RA, Louie SG, Chen TC, Schönthal AH (April 2007). "Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib". Mol. Cancer Ther. 6 (4): 1262–75. doi:10.1158/1535-7163.MCT-06-0629. PMID 17431104.
- ^ Kardosh A, Wang W, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH (May 2005). "Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo". Cancer Biol. Ther. 4 (5): 571–82. doi:10.4161/cbt.4.5.1699. PMID 15846081.
- ^ Xie WL, Chipman JG, Robertson DL, Erikson RL, Simmons DL (April 1991). "Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing". Proceedings of the National Academy of Sciences of the United States of America 88 (7): 2692–6. doi:10.1073/pnas.88.7.2692. PMC 51304. PMID 1849272.
- ^ Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman HR (July 1991). "TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue". J. Biol. Chem. 266 (20): 12866–72. PMID 1712772.
- ^ Yajnik J (2006-10-27). "University sues Pfizer over COX-2 research". The Scientist. Retrieved 2010-11-11.
- ^ Tom Harvey (2010-09-21). "BYU spices up Celebrex lawsuit against Pfizer". The Salt Lake Tribune. Retrieved 2011-02-28.
- ^ Tom Harvey (May 1, 2012). "Pfizer, BYU settle Celebrex lawsuit for $450M". The Salt Lake Tribune.
- ^ Associated Press, May 1, 2012 Pfizer Settles B.Y.U. Lawsuit Over Development of Celebrex
- ^ US Patent 6048850,
- ^ [1]
- ^ Ranjana Kadle (2004) CAFC Court Decision Reach-Through Claims Declared Invalid
- ^ "Aspirin." 101. Mar 2000. pp. 1206–18. PMID 10715270.
- ^ Ethnopharmacol (Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells). 2002. Missing or empty
(help) - ^ A Medical Madoff: Anesthesiologist Faked Data in 21 Studies, Scientific American, March 10, 2009
- ^ a b "Susceptibility to fraud in systematic reviews: lessons from the Reuben case." 111. Dec 2009. pp. 1279–89. doi:10.1097/ALN.0b013e3181c14c3d. PMID 19934873.
- ^ Silverstein FE, Faich G, Goldstein JL et al. (September 2000). "Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study". JAMA 284 (10): 1247–55. doi:10.1001/jama.284.10.1247. PMID 10979111.
- ^ Bombardier C, Laine L, Reicin A et al. (November 2000). "Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group". N. Engl. J. Med. 343 (21): 1520–8, 2 p following 1528. doi:10.1056/NEJM200011233432103. PMID 11087881.
- ^ Johnsen JI, Lindskog M, Ponthan F, Pettersen I, Elfman L, Orrego A, Sveinbjörnsson B, Kogner P (October 2004). "Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo". Cancer Res. 64 (20): 7210–5. doi:10.1158/0008-5472.CAN-04-1795. PMID 15492235.
- ^ a b c d Lau L, Hansford LM, Cheng LS, Hang M, Baruchel S, Kaplan DR, Irwin MS (March 2007). "Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma". Oncogene 26 (13): 1920–31. doi:10.1038/sj.onc.1209981. PMID 16983334.
- ^ http://drugsynthesis.blogspot.co.uk/2012/05/laboratory-synthesis-of-apricoxib.html
Further reading[edit]
- Green GA (2001). "Understanding NSAIDs: from aspirin to COX-2". Clin Cornerstone 3 (5): 50–60. doi:10.1016/S1098-3597(01)90069-9. PMID 11464731.
- Malhotra S, Shafiq N, Pandhi P (2004). "COX-2 Inhibitors: A CLASS Act or Just VIGORously Promoted". MedGenMed 6 (1): 6. PMC 1140734. PMID 15208519.
- Montero Fernández MJ, Rodríguez Alcalá FJ, Valles Fernández N, López de Castro F, Esteban Tudela M, Cordero García B (October 2002). "[At what care level are cyclo-oxygenase-2 inhibitors prescribed?]". Aten Primaria (in Spanish) 30 (6): 363–7. doi:10.1016/s0212-6567(02)79048-3. PMID 12396942.
- "You and A: Arthritis drugs. Pain and confusion"; Francesca Lunzer Kritz; Washington Post; September 4, 2001; HE01.
- "Vioxx (rofecoxib) reduces night-time osteoarthritis pain better than celecoxib or acetaminophen"; European League Against Rheumatism (EULAR) conference proceedings.
- "Will the promise of the COX-II selective NSAIDs come to fruition?"; Drug Ther Perspect 17(11); 6-10, 2001.
- Chancellor JV, Hunsche E, de Cruz E, Sarasin FP (2001). "Economic evaluation of celecoxib, a new cyclo-oxygenase 2 specific inhibitor, in Switzerland". PharmacoEconomics. 19 Suppl 1: 59–75. doi:10.2165/00019053-200119001-00005. PMID 11280106.
- Kamath CC, Kremers HM, Vanness DJ, O'Fallon WM, Cabanela RL, Gabriel SE (2003). "The cost-effectiveness of acetaminophen, NSAIDs, and selective COX-2 inhibitors in the treatment of symptomatic knee osteoarthritis". Value Health 6 (2): 144–57. doi:10.1046/j.1524-4733.2003.00215.x. PMID 12641865.
- "Osteoarthritis drug Celebrex (celecoxib) less likely to cause increased blood pressure than Vioxx (rofecoxib)"; European League Against Rheumatism (EULAR) conference proceedings.
- Johnsen JI, Lindskog M, Ponthan F et al. (October 2004). "Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo". Cancer Res. 64 (20): 7210–5. doi:10.1158/0008-5472.CAN-04-1795. PMID 15492235.
- Dai, C; Stafford, RS; Alexander, GC (2005). "National Trends in Cox-2 inhibitor use since market release: non-selective diffusion of a selectively cost-effective innovation". Archives of Internal Medicine 165: 171–177.
- Solomon, DH; Avorn, J (2005). "Coxibs, science, and the public trust". Archives of Internal Medicine 165: 158–160.


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As has been reported, actor and short-filmmaker Shia LaBeouf is in the middle of something of a scandal, involving a short film he directed that borrowed heavily from a comic book from Daniel Clowes, followed by a public apology that borrowed heavily from a slightly less accomplished source: Yahoo! Answers.
Naturally, we all took to Twitter, and the responses have easily fit into several well-populated categories.
The Meme
In related news: Shia looks to rebound from this scandal with his next film, Forrest Gump.
The Meta
This tweet about Shia's plagiarism is plagiarized.
The Name
Dane Cook: Fellow Plagarizer
Joaquin Phoenix: Erstwhile Fakey-Fake Performance Artist
Hey, it could be worse. Indiana Jones, amirite?


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FINNMN578013: Marttiini Condor Timberjack Fixed Blade
Marttiini Knives
Marttiini Condor Timberjack. 8-1/2" overall. 3-3/4" carbon steel blade. Black textured rubberized handle. Black composition belt sheath.
Marttiini knives have been made in Finland since 1928. The founder of the factory, Janne Marttiini, emphasized from the very outset the significance of efficient working methods, product development and professionalism. By nurturing respected traditions, the Marttiini knives have received worldwide acclaim.


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Château Coutet Barsac 2009
Category: | Dessert Wine |
Varietal: | Sauvignon Blanc, Sémillon |
Region: | France » Bordeaux » Barsac |
Producer: | Château Coutet |
Château Coutet
The first tasting impresses upon us an intense expression of the wine, its depth and its complexity, with fresh and exotic flavors, lots of citrus, quince and apricot. The sensation of coolness is enhanced by the brightness of the fruit. The sweetness is present with hints of roundness and opulence.
Wine Enthusiast
96-98 Barrel sample. A wine that shows intense spice, with ginger and grated nutmeg. This lies over the top of the ripest yellow fruits, added to mango, sweet pears and a fresh, final character. Complex wine with an immense future.
Score: 96-98. —Roger Voss, August 09, 2010.Wine Advocate
The Coutet 2009 is a sensational effort from Philippe Baly and his team. It has a fragrant nose of honey, vervain tea, pineapple, frangipane and apple-blossom, well defined if needing a little more vigour at the moment. The palate is vibrant on the entry, informed by touches of apricot and orange peel, very focused and tensile towards the long, sensuous, viscous finish. It has the same minerality exuded by Doisy-Daene and reminds me of a stellar '62 tasted just a few weeks previously. A magnificent Coutet.
Score: 96-98. —Neal Martin, April 2010.Wine Spectator
Very lightly toasty, this is more floral for now, with lively honeysuckle and pineapple notes up front, giving way to richer hints of warm brioche, fig, glazed pear and lemon shortbread that should emerge more with time. The long, lacy finish has the poise and balance for long-term cellaring. Sémillon, Sauvignon Blanc and Muscadelle. Best from 2014 through 2034. 5,000 cases made.
Score: 95. —James Molesworth, March 31, 2012.TERMS AND CONDITIONS: Subject to availability. Payment required upon confirmation.
We anticipate delivery in the Spring 2012.
Case discounts do not apply to this item.
Vintages and ratings subject to change at any time.
All pricing and availability subject to change.


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Other projects made by brandymccoy79:
See All Projects by brandymccoy79 »Offer some kudos...
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Here are some details about my project: | |
Category | Quilting |
Type | Home Decor |
Style | Casual |
it's beautiful! i wish i had one just like it lol. has my favorite colors =) your title for it made me think of a dimentia patient i took care of, anything she didn't like was "for the birds" lol. i've moved since then so there are little things like that that make me think about her :D thanks!
Thank you:)


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The Library
Multiple dielectric relaxation processes in an unequilibrated bisphenol-A polycarbonate
UNSPECIFIED. (1996) Multiple dielectric relaxation processes in an unequilibrated bisphenol-A polycarbonate. POLYMER INTERNATIONAL, 40 (4). pp. 239-249. ISSN 0959-8103
Full text not available from this repository.Abstract
Complex relative permittivity data within the ranges 0.1 Hz-3 MHz and -175 degrees C to +200 degrees C are presented for an unequilibrated compression-moulded bisphenol-A polycarbonate of commercial origin (LEXAN 141). Comparisons are drawn with the nitrogen-equilibrated material in which eight distinct absorption regions have been identified. One low-frequency region common to both materials at low temperature is shown to be caused directly by a processing stabiliser. A second at high temperature is thought to originate in part from an interfacial polarisation associated with a second phase of polycarbonate. An absorption observed only in the unequilibrated polycarbonate is attributed to bound water. Two intermediate-temperature losses are differentiated and delineated for the first time. Their origins and reason for diminution by annealing are examined. The multiplicity of overlapping absorptions, including a low-temperature loss region which is almost continuous at higher frequencies, is consistent with the high impact strength of polycarbonate over an extended temperature range.
Item Type: | Journal Article |
Subjects: | Q Science > QD Chemistry |
Journal or Publication Title: | POLYMER INTERNATIONAL |
Publisher: | JOHN WILEY & SONS LTD |
Official Date: | August 1996 |
Volume: | 40 |
Number: | 4 |
Number of Pages: | 11 |
Page Range: | pp. 239-249 |
Publication Status: | Published |
URI: | http://wrap.warwick.ac.uk/id/eprint/18522 |
Data sourced from Thomson Reuters' Web of Knowledge
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Michael Jackson's blanket of secrecy to be removed?
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29-04-2013, 17:38
Forum Member
Join Date: Jun 2012
Posts: 22,289
Originally Posted by
Unfortunately he didn't think of the chidren he bought and calculatingly deprived of mothers did he? He was a mess and meddled with the lives of others to create some sort of dysfunctional family. A pitiful man but he is not the only one who deserves sympathy here.
So if you don't have a partner you shouldn't have kids? He didn't calculatingly deprive the children at all, the mother to the eldest two did not wish to be a mother but was happy to make MJ a father, there is nothing wrong with that and I'm pretty sure Prince and Paris don't see what their father did was calculating they see a man who brought them up, tried his very very best to keep them out of the public eye, with the masks and all that stuff, and afforded them a very good lifestyle
Are you saying any parent who gets their children through a surrogate is calculatingly depriving them of mothers, even if said surrogate doesn't wish to be one?
I never even said he deserved sympathy either, I said the man deserves to rest in peace and not have a multi-million dollar company and his family fighting over money using his name to do so, they both made a shed-load of money through Michael and unfortunately in death, to them he has become that much more valuable
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I am not really a collection type of person. I have never been one to want shelves of random things around- but I do have one collection I love. I love this collection because it has lots of meaning (no random pieces in it). Tyler gave me the first one when we were dating, the next when we got married and the others were give after each of our kids were born.
Wednesday, June 22, 2011
The Collection
1 comment:
- Debbie said...
I love the idea of a treasure that you look forward to all of your life. I bet the kids really love them.
Good job Tyler !!!!!!
Love, Mom - June 23, 2011 at 2:39 AM
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Comprehensive databases for nanomaterials, events, products,
companies, research labs, degree programs and publications
Nanoscribe develops compact and easy-to-operate table-top laser lithography systems, allowing for true three-dimensional nanostructures in commercially available photoresists. Furthermore, the company offers the service of producing samples specially designed for the needs of the customer, including also the conversion or inversion of 3D structures into SiO2 and Si, as well as writing into different photoactive materials, such as chalcogenide glasses.
Address: | c/o Forschungszentrum Karlsruhe GmbH, Institut für Nanotechnologie, Hermann-von-Helmholtz-Platz 1 |
City: | Eggenstein-Leopoldshafen |
State/Province: | |
Postcode: | 76344 |
Country/Region: | Germany |


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Okay, let us say, that superman maxed charged, is able to fly through the core of a yellow star. The temperature inside the core of a yellow star like the sun is around 14.5 million K. Now, there are many kinds of red stars, red dwarf stars, red giant, and red supergiant. The one in the superman comic was definitely a red giant called Rao since the author himself had stated that its size was vastly larger than the sun. Therefore, it was 100x the size, the core temperature of a Red giant is around 100 million K. In laments terms, that's about 7 times hotter than what superman can take. Even if he was traveling at the speed of light through the core, he would not have his regeneration abilities since his power would be nullified once he reaches the core, he'd be dead before he could come out of it. Now, if it was a red dwarf, sure, but it's not.
I ask you again, have you watched/read DB? Vegeta was whooping Goku's ass until Goku went Kaioken x3. When Goku arrived on Earth, he said he would only use Kaioken for emergencies and was saving it for Vegeta. He forced himself to use it against Nappa to protect Gohan. That's why he used Nimbus instead to get there. Ki here has nothing to do with it. Also, Vegeta had to POWER not unpower in order to use his Gallick gun.
It's so difficult to read your sentences. Wth are you talking about? The distance between the planet and the star wasn't revealed, how are you to say it was too close or not. You only know how far it was with respect to the Earth. In the real world, the next closest star after the sun is Proxima centauri, which is 4.2 light years away from us. It took them 3 light years to come to Earth from their planet. As for Vegeta and Nappa stopping and taking a break at that planet - that was FILLER! The spaceship used to travel to Namek was of a different design and even faster than the normal saiyan spacepod. Dr. Briefs designed the spaceship so that Goku could train under 100x Earth's gravity. The spaceship was still traveling at the speed of light though, not faster. The higher the gravity, the more bend you put into space. If you bend the space infront of you, then you can reach the destination faster. This is the basics of interstellar travel without breaking the rule of going faster than the speed of light.
I think you need to re-watch/re-read all of DBZ again. I'm tired of re-stating what is already been shown. Freeza himself stated that he would destroy the planet Namek so that he would survive and Goku wouldn't. Both of them can survive the explosion, but Goku cannot breathe in space. This was clearly stated, go back and watch/read it. You also need to re-watch/re-read the part when Goku fights Future Trunks, he puts up his index finger and then an aura surrounds only his index finger.
You know nothing about self-destruction. Cell was in his second form, if he tried to blast the Earth, most of the Z-fighters could have blocked/deflected it easily. Cell knew the only thing that would have enough power was self-destruction. Yes, it took lots of time and Gohan could have prevented it, but it was too late. Gohan got over-confident in his SSJ2 state. Once, Cell was already in a bloated-state, you couldn't do anything, it's like if you were to attack a bomb, it would still explode. This is why Gohan was so pissed at himself for not listening to Goku earlier and finishing the fight, instead Goku had to sacrifice his life.
The ozone covers the entire surface area of the Earth. Gohan's kamehameha blew Cell into 1 small hole of that surface area. The ozone is just made of gasses that can easily re-form if a small tear like that happens.
This argument is a 1-way battle man. You are asking questions and I am answering all of them. When I ask a question, which has been the same question since the beginning of the thread, your answer is, "I don't have to explain because it was done".


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O taste and see that the Lord is good; how blessed is the man who takes refuge in Him! -- Psalm 34:8
It may still be dark, but I am able to see.
We stumble along way too long.
Compassionate truth for men and women who struggle with sexual brokenness, whether pornography, unwanted same-sex attraction or sexual addiction. The struggle can be all-consuming and extremely costly, leading to harsh judgment from family, friends, the community and the church, and the loss of valuable relationships. Through a relationship with Christ and the power of the Holy Spirit, strugglers can overcome, to continue on in hope, accepting grace and rebuilding their lives.
Reactions: |
Thank you Thom, so true. Romance and lust are relative diceptions which fail and hurt. Ive been there. Im 57. Male, Divorced 22 years.
Father of 4. In my years of false conforming and then the irritation of disfuncitional family and church members, i am now wiser and cautious. Be as wise as a serpent.
It was the last and final draw. I had no choice do to extreem behaviors. I believe carnal churchs spread contagious sickness are also powerless to heal. Carnalality, selfism, self righteousness. Etc. They can not heal nor love nor grow others beyond....
Forgiveness does not mean resubmitting to the abuse. Kind David fleed for his life.
And often we can mindlessly conform and find toooo much comfort in gathering which keep us babies.
But your blog here is so bold and honest that one must resolve to only repent.
Romantic lust is evil deception. Western thinking is blinded and only God can heal.
Thank you Rick . firstname.lastname@example.com
Also i had the pleasure of hearing speaker Wess Wheatly in Mn years ago. His testimoney of Gods huge love and healing and diliverance of lust.
Dynamic powerfull words of life and prayer time we had.
Wess had a tragity with his dad at an early age that set set world toward carnal lust distruction and Jesus set him free.
If i recall wess was playing catch with his dad when Wess was hit hard with a baseball to his chest that knocked the wind out of him and he laid on the ground for a long time while his dad left him.
This caused Wess to be mentality changed to the point that he could write ambidextrous and left and right opposites both at the same time.
However with a poor dad relationship this led to seeking out lust for fulfillment.
See Paraclete ( minetrys news letter)(and check my terrible spelling)
Thanks and God bless with his limitless love. Rick mpls mn


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Hey y'all has anybody come across this yet? "Brain Diagram" Brandon's acrilyc and marker on canvas painting has finally come up for resale…
Started by Eric SCHONER
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Naruto Sakura Haruno Cosplay Costume
The Lady of the Pack!One of the best pals of Naruto and the smartet of the group, you will surely love to become Sakura. Her style can fit anyone so just like this Naruto Sakura Haruno Cosplay Costume. Get it now and you will have her Cheongsam and Pants Sakura Haruno cosplay will only be wonderful with this comfortable Naruto Cosplay Costume.
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Product Review
To do a vivid Sakura Haruno cosplay, you can't omit this Naruto costume. It's made from luxurious cotton and strictly designed to be faithful to the anime. For sure, you will desire to feel confident about your Sakura Haruno cosplay performance. Since this Naruto cosplay costume is available on $36.79 at present (due to 20% off activity during the weekend), why not check it out to enrich your look now? CUSTOMER REVIEWS1 Reviews
Average Customer Review
The most helpful favorable review1 of 1 people found the following review helpful: The costume is great fit well Thank you i order from you again in the near future :) The most helpful critical review1 of 1 people found the following review helpful: The costume is great fit well Thank you i order from you again in the near future :)
Our Cosplay Costumes,wigs and other accessories will be shipped from HongKong and USA directly, it takes about 10-15 business days to customize a costume if they are not in stock, and usually takes about 5-7 days for the costumes to get to your place after they are finished via DHL, EMS or UPS.
The Cosplay Shoes are customized, even if you choose regular size or custom-made size. It usually takes about 5-7 business days to process a pair of shoes and 5-7 days around for the shoes to get to your place after they are finished. We advise you to place an order early so that there are enough time before you receive the costumes or shoes. We can ship items in your order separately to ensure that customers can receive the items earlier. Attention: The processing and shipping of the orders during legal holiday will be delayed to some extent. We appreciate your understanding. We accept payment via Paypal and Credit Card directly
We accept returning for replacement or refund within 3 days after you receive the costumes,dressesor wigs. The cost on the merchandise will be totally refunded. But the shipping cost is not refundable.
Following are conditions on which return is not accepted:
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July 24, 2013 7:15 pm
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purist said: The following maps also use still use stock music. (...) MAP19 Satan's Fortress by Cell (...) If the authors of these maps want to keep the stock music let me know otherwise I'll take the next offer for new music for these maps too.
purist said: I'm guessing you can't have new music for the story text screens? That was going to be my next request.
purist said: I like it but I think the guitar could do with a slightly slower tempo. More importantly, it doesn't loop as seamlessly in game as it needs to for such a short track. Making it a bit longer would be just as good a fix, even if it was effecively just repeating. It's in the beta for now still. Are you titling it or should I just credit you with D_READ_M music?
purist said: @Cell I'll leave MAP19's music alone then. I either didn't realise or forgot you left it as stock music by design. I think that's pretty much all for music then. Just need MAP30 to be completed and the beta can go out.
purist said: Planned release date for Hadephobia is 22nd of October, which would make a nice birthday present for me :-)
Last edited by purist on 09-06-12 at 21:26
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purist said: First up is Melon's music selected for MAP25. He's not said what it's called - anyone recognise where this has been borrowed from?
purist said: Cell, your original MAP26 attempt used this track, which I've not noted the origin of. Anyway, I seem to remember you wanting to use the music from MAP32 in Scythe - am I right? Scythe's text file does not credit the music it uses but according to the wiki it is CRUCIBR from Hexen, which was composed by Kevin Schilder. I don't have Hexen but the Scythe MAP32 music does not resemble Bright Crucible. Can anyone shed any light? EDIT: If anyone who has contibuted to the project wants to be credited by a particular name let me know otherwise you will be credited by your Doomworld username.
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