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Mar. Drugs 2014, 12(1), 317-351; doi:10.3390/md12010317
Thiopeptide Antibiotics: Retrospective and Recent Advances
Received: 27 November 2013 / Revised: 13 December 2013 / Accepted: 16 December 2013 / Published: 17 January 2014
(This article belongs to the Special Issue Selected Papers from the 14th International Symposium on Marine Natural Products)
Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of biological properties, including anticancer, antiplasmodial, immunosuppressive, etc. In spite of their ribosomal origin, these highly posttranslationally processed peptides have posed a fascinating synthetic challenge, prompting the development of various methodologies and strategies. Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential.Keywords:
thiopeptides; antibiotics; natural products; peptides; heterocycles; thiazole; oxazole; dehydroamino acids; pyridine
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Just-Baringo, X.; Albericio, F.; Álvarez, M. Thiopeptide Antibiotics: Retrospective and Recent Advances. Mar. Drugs 2014, 12, 317-351.
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Last Friday I was brainstorming with Gabrie van Zanten about the optimal placement of the VMDKs across our LUNs. We tried to come up with an algorithm that could give us insight in what would be our optimal storage layout.
First read the complete post here.
This weekend I was continuously thinking about this challenge.
I came up [...]


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News for the Hospitality Executive |
Judy Hendrick Joins Aimbridge Hospitality
as Chief Financial Officer
of rapidly growing hotel-management and -investment company DALLAS, TEXAS MAY 7, 2008 Aimbridge Hospitality has appointed hospitality-, real-estate and financial-industry veteran Judy Hendrick to the position of Chief Financial Officer. Hendrick comes to Dallas-based Aimbridge Hospitality from Wyndham Hotels
International, where she served as Executive Vice President - Chief Investment
Officer, and Senior Vice President of Finance and Treasurer, during her
16-year tenure there. She has held positions with major financial institutions
such as Chase Manhattan, Canadian Imperial Bank of Commerce and First Republic
Bank, and also has managed commercial portfolios for major public real-estate
investment trusts.
Katy Walterscheidt