text:
The Italian Job is based on the 1969 movie of the same name. You take on the role of lovable rogue gang leader Charlie Croker in his attempt to steal $4,000,000 worth of gold in broad daylight from under the noses of the Polizei and Mafia. In Turin, the Alps, and London you'll thrash about in the Austin Mini Cooper S as well as sports cars, 4x4s, and a bus. There are 6 game modes including 16 'The Italian Job' missions and 2 massive 'Free Ride Levels'.Gameplay
The Italian Job is an arcade driving game with three modes of play - Story Mode, Circuit Racing and Stunt Driving. The Story Mode is based on the film's plot as you attempt to steal $28 million in gold bullion from under the nose of the man who betrayed you. The game features 15 different missions utilising a range of vehicles and gameplay styles. Create havoc on the streets of LA as you drive at break-neck speeds through environments based on locations in the film including the Hollywood Hills, Downtown LA and the city's Metro and storm drain system.Features
- Story Mode based on the film's plot featuring 15 missions with a variety of gameplay styles.
- Circuit Racing for 1 or 2 players (split-screen) around tracks based on locations from the film.
- Test your driving skills to the limit in the Stunt Driving offering you the chance to control a Mini Cooper over various obstacle courses.
- Environments based on locations from the film including the Hollywood Hills, Downtown LA and the city's Metro and storm drain system.
- Tear through the streets of LA in a variety of vehicles ranging from the new Mini Cooper and muscle car to an armoured truck and cable van.
- Cutting edge graphics engine running at a constant 60 fps (frames-per-second) with highly detailed textures and spectacular graphical effects.
- Exhilarating car handling and realistic damage model including body deformation and component removal.
- The story unfolds through the use of cinematic cut-scenes and voice-overs.
- Hidden extras including movie footage, interviews with the film's cast, film stills, concept art etc.
Recent threads
- Scam free jobs (5579) Feb 5
- Earn extra money (5579) Jan 13
- cheap Mar 28
- The Italian Job cheats, PSX Mar 7
and 4 others own The Italian Job
and 1 others played The Italian Job
I would do anything to get my g.f. off my back to buy this game TheItalianJob PSX
"This is the Self Preservation Society..."
This game shows just what the Brits do best with visual entertainment - adding humour...
A cheap game based on the 1969 hit movie of the same name. Hours of addictive driving fun. TheItalianJob PSX
Italian Job
This game is actually pretty difficult to play unless you have a few hours to spend...
A Okay Game!
It's a excellent game, but don't let it go to your head for 2002, the graphics; are...
20th century Moderns
This game is strictly for fans of the movie, it is a bit like Diver 2, but far better...
The Italian Job
The grapics Suck big time. Its not as fun. You can't even know where your going. Alot...
Maybe more interesting than Driver 2 ........
Hmm. This game is maybe better than Driver 2. The graphics are great. I don't know if...
I am a huge Italian Job Fan and I whent out and brought a Playstation so I could enjoy...
$4 Million dollors through a traffic jam!!!!!!!!
This is an excellent realisation of the film... Despite a few shortcomings, it has to...
- Genre: Automobile (PSX)
- Perspective(s): First Person,Third Person
- Developer: SCEI
- Publisher: SCEI
Released North America May 6, 2002


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October 3, 2012 Service as an Opportunity Aquarius Daily Horoscope
You may feel kindhearted and compassionate today, which could lead you to offer assistance to friends or family members. You can deepen the richness of these experiences for others and yourself by choosing to see your service as an opportunity to spread some positive energy to those who need it. Rather than mindlessly performing chores or activities on behalf of others today, simply focus on immersing yourself fully in the experience with a mind-set of joy and gratitude. In your mind's eye, watch each of your actions release a burst of positive energy that makes its way to the people you are assisting. Imagine this energy filtering through their lives, clearing away difficulties and bringing forth new and wonderful circumstances.
For more information visit dailyom.com
This article is printed from DailyOM - Inspirational thoughts for a happy, healthy and fulfilling day.
© 2004-15 DailyOM - All Rights Reserved
No portion of this site can be reprinted without express permission

subset: commoncrawl


text:
Newton County school officials discussed four possible budget scenarios for the next school year that could cease any furlough days, increase the amount of money paid to the Teacher Retirement System (TRS) and raise for all employees' salaries in the Newton County School System (NCSS).
What your growing child needs from you, right now.
Realizing Educational Achievement Can Happen (REACH) Georgia has announced that the Newton County School System (NCSS) is one of 19 additional Georgia school systems that will be participating in the program in the 2015-2016 school year. Georgia school systems had the opportunity to apply to participate in REACH Georgia during the application process that was open from December 1 through February 25.
I throw my hands in the air, and do a short, ridiculous dance. "It's Friday!" I exclaim, and I walk out of the office and into my sanctuary. I leave the lights off and sit at my desk, black coffee steaming in front of me.
The word "assessment" might make students, parents and even some teachers nervous.
Page 1 of 1
During a special called meeting on Tuesday, August 27, the Newton County Board of Education unanimously supported joining an "amicus brief" in support of the Georgia School Boards Association and the Georgia School Superintendents Association's court challenge to the Georgia's Charter School Commission.
Newton County School System on Tuesday officially entered into an articulation agreement with DeKalb Technical College that affords students the opportunity to earn 12 college credits upon completion of the Small Business Development Pathway. The agreement with DeKalb Tech also includes students in four other local school districts - Decatur City, DeKalb, Morgan, and Rockdale County school systems.
Governor Sonny Perdue announced Tuesday that Georgia was selected as a winner by the U.S. Department of Education for the second round of "Race to the Top" grants. The state is projected to receive $400 million over four years to implement its plan.
A college collage: Freshmen started to arrive at Oxford College for the 2010-2011 school year on Wednesday. Their six-day orientation had the new scholars move in to their residence halls, participate in team-building and community building activities and to learn the lay of the land. Classes at Oxford College begin on Wednesday, Aug. 25.
In my "Letter from the Superintendent" (CN, Aug. 15, 2010), I suggested that when all is said and done, instruction itself has the largest influence on achievement. Unfortunately, despite our best efforts, instruction is not always as effective as it could be, but could improve swiftly and significantly through ordinary and accessible means.
More high school students in Newton County are learning the benefits of Dual Enrollment (DE) programs offered at Georgia Perimeter College.
GPC's DE numbers are up 76 percent from last year, with 116 students enrolled in the Newton campus, compared to 66 students from last year. There are a total of 813 students attending DE at GPC's five campuses.
More students in Newton County took the ACT college entrance exam in 2010; however, test scores have declined slightly from 2009.
The Newton County Board of Education is revamping its tribunal procedures in order to allow administrators to spend less time in tribunals and more time in their schools.
Ready for school: Dustin Kendall, 14, Brianna Kendall, 13, Faith Kendall, 10, and Elisabeth, 5, are all smiles and ready for school. For the 21st year the Pine Valley Mission has furnished school supplies, book bags, shoes and clothing to children in the High Point/Heard-Mixon area. Two sets of new clothing were given along with other required school items. The items were distributed before the start of school. The mission furnishes these supplies for the entire year, along with winter coats and sweaters. The Pine Valley Mission is located at 12185 Highway 36 and is staffed entirely by volunteers.
The 2010-2011 school year opened Thursday, Aug. 12, at Piedmont Academy with an enrollment of 314 students. There are 139 students in grades K4 through 5; 80 students in middle school; and 95 students in high school. Two-hundred-six families are represented at the school. This number includes 24 new families. 23 percent of this year's student body has alumni parents or grandparents. Drawing from an eight-county area, Jasper County represents 50 percent of the student body. Newton County represents 28 percent and Butts represents 18 percent, an increase from last year. Other counties represented include Rockdale, Putnam, Henry, Morgan ...
Newton student receives Piedmont academic honor
Wendy R. Shivers of Covington was named to the Dean's List at Piedmont College after completing the recent summer semester with a grade-point average between 3.5 and 3.99 out of 4.0.
Big winners: Alcovy High School and Rocky Plains Elementary School were both awarded their checks by Big Lots Friday. The two schools won $2,000 in the Lots2Give contest sponsored by Big Lots. More than 200,000 votes were cast. Rocky Plains won money to purchase more COWS (computers on wheels) and Alcovy won money for their arts program.
The Newton County Board of Education is already planning for rezoning next year; this time it's the elementary schools that will be affected.
Back to school bonanza: Enterprise Lodge No. 551 held a Back To School give away on Aug. 7. There was free food and drinks and 100 back packs with schools supplies were given to the first 100 people to sign up at the event. There will be music, games and more. The Back to school give away was a joint effort between Enterprise Lodge No. 551 and Lemon Chapter No. 34 of Covington.


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Restorative Dentistry
Subject Specialist in Restorative Dentistry | |
Prof. Joan Grassano | |
email@example.com |
Phone |
718.260.5478 |
Department |
Contents |
Getting Started with Research in Restorative Dentistry
This guide will help you get started with research in restorative dentistry.
The library's online databases provide access to articles and images in journals, magazines, newspapers and reference sources. To access the databases listed below, all important in dental research, click the Articles tab on the library website and select Databases (articles & more).
Academic Search Complete (EBSCO)
This multi-disciplinary database provides full-text articles from over 7,800 peer-reviewed journals covering nearly every area of academic study.
Business Source Complete (EBSCO)
Offers full-text articles from nearly 2,000 peer-reviewed journals in all business disciplines. Additional full-text content includes case studies, company profiles, industry reports, market research reports and executive/analyst interviews.
Health Reference Center Academic (Gale)
Provides a wide variety of resources for health-related research. Full-text coverage includes professional journals, health magazines and newspapers, and medical reference books. Designed for students, health professionals and knowledgeable, consumer health researchers.
This database provides access to full-text news, business, legal and medical publications.
MEDLINE Complete (EBSCO)
This database includes citations and abstracts for biomedical and health journals published in the United States and worldwide. Medicine, dentistry and health administration are among the fields covered. Provides the full text for more than 2,400 journals.
The National Library of Medicine's search system for health information. Contains millions of references to articles published in biomedical and life sciences journals. Many references have links to full-text articles in PubMedCentral, a free digital archive. Most PubMed references are MEDLINE citations.
Journals and Magazines
The library has many journals and professional publications of interest to the dental laboratory technologist. Several key titles are listed below:
Dental Materials
Journal of Dental Technology*
Journal of Esthetic and Restorative Dentistry
Journal of Prosthetic Dentistry
Journal of Prosthodontics
Journal of the American Dental Association
Quintessence of Dental Technology: QDT*
* Available in print. Ask for assistance at the periodicals desk, located on the 4th floor of the library.
Are you looking for a specific journal or magazine? Click the Journals tab on the library website. You can search or browse by journal or magazine title or browse by subject in Health & Biological Sciences. If you need an article from a magazine or journal at another library, you may request it through interlibrary loan.
Finding Books and More in the Library
Use CUNY+, the library's online catalog, to find books,videos and other resources on restorative dentistry and dental laboratoy technology. You can begin searching right on our homepage. Here are some of the many subject headings to use in your search:
Would you prefer an ebook? Although each of the library's ebooks is included individually in CUNY+, you can also search for ebooks within a specific collection. Follow this link for a list of the library's ebook collections. Quick tip: ebrary, a collection of over 46,000 ebooks on scholarly topics, has numerous titles pertaining to dentistry.
Reference Resources
Need an overview of your topic? Looking for high-quality dental photography? the meaning of a word or concept? A reference resource or a textbook is often the best place to begin your research or find specific information. Here are just a few of the many reference resources and textbooks that may be useful in your research. All are available at the City Tech library.
Babbush, C. A., Hahn, J. A., Krauser, J. T., & Rosenlicht, J. L. (2011). Dental implants: The art and science (2nd ed.). Maryland Heights, MO: Saunders. CALL NUMBER: Reserve -- Three Weeks RK667.I45 D485 2011
Bruguera, A. (2003). Shades: A world of colour. Victoria, Spain: Puesta al día Publicationes. CALL NUMBER: Reserve & Reserve -- Three Weeks RK54.B78 2003
Dawson, P. E. (2007). Functional occlusion: From TMJ to smile design. St. Louis, MO: Mosby. CALL NUMBER: Reserve -- Three Weeks RK523.D383 2007
Massironi, D., Pascetta, R., & Romeo, G. (2007). Precision in dental esthetics: Clinical and laboratory procedures. Milan, Italy: Quintessenza Edizioni Srl. CALL NUMBER: Reserve -- Three Weeks RK54.M37 2007
Mosby's dental dictionary (2nd ed.). (2008). St. Louis, MO: Mosby. CALL NUMBER: Reference & Reserve -- Three Weeks RK27.M672 2008
Nelson, S. J., & Ash, M. M., Jr., (2010). Wheeler's dental anatomy, physiology, and occlusion (9th ed.). St. Louis: MO: Saunders. CALL NUMBER: Reserve RK280.A74 2010
Phoenix, R. D., Cagna, D. R., & DeFreest, C. F. (2008). Stewart's clinical removable partial prosthodontics (4th ed.). Chicago, IL: Quintessence. CALL NUMBER: Reserve -- Three Weeks RK665.S73 2008
Proffit, W. R., Fields, H. W., Jr., & Sarver, D. M. (2007). Contemporary orthodontics (4th ed.). St. Louis, MO: Mosby. CALL NUMBER: Reserve -- Three Weeks RK512.P76 2007
Rosenstiel, S. F., Land, M. F., & Fujimoto, J. (2006). Contemporary fixed prosthodontics (4th ed.). St. Louis, MO: Mosby. CALL NUMBER: Reference & Reserve -- Three Weeks RK666.R65 2006
Ubassy, G. (2003). Analysis: The new way in dental communication. Villa Carcina (BS), Italy: Teamwork Media Srl. CALL NUMBER: Reserve & Reserve -- Three Weeks RK54.U23 2003
Quick tip: Gale Virtual Reference Library has a large collection of online, medical reference books that may be of interest.
Multimedia Resources
Multimedia resources are an important part of the library's restorative dentistry collection. Selected titles are listed below, all of which are housed in the library's Multimedia Resources Center (A431). Faculty may borrow videos to enhance classroom instruction; students may view videos in the Multimedia Resources Center.
3D Interactive Tooth Atlas (DVD RK280.B76 2006)
Casting orthodontic impressions and base formers (VIDEO CASSETTE 1640)
Ceramics (VIDEO CASSETTE 470)
Combined fixed/removable prosthesis with the SAE Spark Erosion System: Clinical and laboratory aspects (VIDEO CASSETTE 1135)
Complete dentures (VIDEO CASSETTE 468)
Crown and bridge (VIDEO CASSETTE 469)
Esthetic implant dentistry: Single tooth replacement with ITI Dental Implant System (VIDEO CASSETTE 1221)
Habit appliances (VIDEO CASSETTE 1155)
Mechanics of dentures (VIDEO CASSETTE 1156)
Porcelain building: Five Surface Domain-Range Build-Up System (VIDEO CASSETTE 644)
Porcelain finishing: Staining, glazing, corrections & polishing (VIDEO CASSETTE 645)
Retainer construction (VIDEO CASSETTE 1154)
Space maintainer construction (VIDEO CASSETTE 1240)
Internet Resources
The websites in this selective list will lead you to a wealth of information on dentistry and oral health.
CDC Division of Oral Health (DOH)
National Institute of Dental and Craniofacial Research (NIDCR)
NOAH: New York Online Access to Health
WHO Global Oral Health Programme (ORH)
Professional Organizations
Professional organization websites often provide valuable, discipline-specific information as well as links to quality resources in the field. Here are just a few of the many professional dental organizations of interest to the dental laboratory technologist.
American Academy of Cosmetic Dentistry
American College of Prosthodontists
Dental Laboratory Association of the State of New York


text:
[Brought to you by the Blue Letter Bible]
"Do not judge so that you will not be judged. |
"For in the way you judge, you will be judged; and fnby your standard of measure, it will be measured to you. |
"Why do you look at the speck that is in your brother's eye, but do not notice the log that is in your own eye? |
"Or how fncan you say to your brother, 'Let me take the speck out of your eye,' and behold, the log is in your own eye? |
"You hypocrite, first take the log out of your own eye, and then you will see clearly to take the speck out of your brother's eye. |
"Do not give what is holy to dogs, and do not throw your pearls before swine, or they will trample them under their feet, and turn and tear you to pieces. |
"For everyone who asks receives, and he who seeks finds, and to him who knocks it will be opened. |
"Or fnif he asks for a fish, he will not give him a snake, will he? |
"If you then, being evil, know how to give good gifts to your children, how much more will your Father who is in heaven give what is good to those who ask Him! |
"Enter through the narrow gate; for the gate is wide and the way is broad that leads to destruction, and there are many who enter through it. |
"For the gate is small and the way is narrow that leads to life, and there are few who find it. |
"Beware of the false prophets, who come to you in sheep's clothing, but inwardly are ravenous wolves. |
"So every good tree bears good fruit, but the bad tree bears bad fruit. |
"A good tree cannot produce bad fruit, nor can a bad tree produce good fruit. |
"Every tree that does not bear good fruit is cut down and thrown into the fire. |
"So then, you will fnknow them by their fruits. |
"Not everyone who says to Me, 'Lord, Lord,' will enter the kingdom of heaven, but he who does the will of My Father who is in heaven will enter. |
"Many will say to Me on that day, 'Lord, Lord, did we not prophesy in Your name, and in Your name cast out demons, and in Your name perform many fnmiracles?' |
"And then I will declare to them, 'I never knew you; DEPART FROM ME, YOU WHO PRACTICE LAWLESSNESS.' |
"And the rain fell, and the fnfloods came, and the winds blew and slammed against that house; and yet it did not fall, for it had been founded on the rock. |
"Everyone who hears these words of Mine and does not fnact on them, will be like a foolish man who built his house on the sand. |
"The rain fell, and the fnfloods came, and the winds blew and slammed against that house; and it fell—and great was its fall." |
fnWhen Jesus had finished these words, the crowds were amazed at His teaching; |
for He was teaching them as one having authority, and not as their scribes. |
New American Standard Bible
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text:
Aizawl (Mizonews.Net): Mizoram Chief Minister Lal Thanhawla on April 22 launched the Mizoram State Rural Livelihood Mission aimed at eradicating poverty in the hilly state.
The mission has been set up as per the National Rural Livelihood Mission (NRLM) under the Union Ministry of Rural Development. The inauguration programme was held at CMO Conference room.
The Chief Minister recalled several initiatives of the government that had been undertaken for elevation of poverty and for uplift of the poor like Integrated Rural Development Programme (IRDP), Training of Rural Youth for Self Employment (TRYSEM), Development of Women and Children in Rural Areas (DWCRA) and others.
"NRLM was set up in June 2011 as the Central government is concerned for the progress and development of the rural poor and the downtrodden population in the country," the chief minister said.
R.Lalzirliana, Rural Development Minister, the Guest of Honour at the inauguration programme, said NRLM is a new thing for Mizoram. He said that the Ministry of Rural Development in 1999 carried out Swajayanti Gram Yojana (SGSY) with a mission to reduce poverty, but due to some issues it has been transformed into National Rural Livelihood Mission.
The Minister also mentioned that this mission was started in Mizoram since 2012, and said it is an autonomous body. Lalzirliana added that the ruling government which is a "pro-poor government will continue doing its best."
Smita Jacobs, Consultant, Ministry of Rural Development, on behalf of Central Government, gave detailed explanation on the beginning and objectives of NRLM.
NRLM, the mission for elimination of poverty, mainly focuses the rural poor. It will have multi-pronged approach to strengthen the livelihoods of the rural poor by promoting Self Help Group (SHGs), providing skill development and setting up of Rural Self Employment Institutions. Banks are also expected to extend cooperation for provision of financial assistance to the poor.
Mizoram is the first among the North East States to carry out the National Rural Livelihood Mission. The Team which will carry out the Mission in the State has been selected, and selection for the team to work at Block level is also going on. Moreover, Annual Action Plan for 2012 – 2014 has also been approved in December 2012.
The inauguration programme conducted by Lalrinmawia Ralte, Parliamentary Secretary for Rural Development Department was also attended by Education Minister Lalsawta.


text:
© 2007 Lawrence Tuczynski
Title: | Kamen Rider Hibiki - Original Soundtrack 3 |
CD Label: | Avex Entertainment Inc. |
CD Number: | AVCA-22555 |
Music by: | TOSHIHIKO SAHASHI |
Number of tracks: | 67 |
Running time: | 65:22 |
Number of discs: | 1 |
Year of release/manufacture: | January 18, 2006 |
September 24, 2007 This starts off with a male vocal track with backup chorus. I'm thinking it's probably the main theme song. As with the other soundtracks in this series there is a lot of xylophone use. Unlike the other two soundtracks most of the tracks on this CD are slower paced and more laid back with very little action type music.Overall it's a nice sounding CD like the rest in the series but the 1st one Kamen Rider Hibiki - Original Soundtrack (AVCA-22307) is my favorite of the series. |
Kamen Rider Hibiki - Original Soundtrack 3


text:
Schools in Ahoskie, NC
About Ahoskie Schools
- There are 7 K-12 schools in Ahoskie, NC, including 5 public schools and 2 private schools. Ahoskie public schools belong to one districts, Hertford County Schools School District.
- There are 4 Ahoskie elementary schools, 2 Ahoskie middle schools, 5 Ahoskie high schools and 22 Ahoskie preschool schools.
Contact Education.com with questions or feedback about SchoolFinder.
Please note, if you wish to speak to someone at the school, you must contact the school directly.


text:
The indefatigable Cory Doctorow has a piece posted by the Guardian using rather quite colorful language to describe the conundrums posed by positioning Google Plus as an "identity service". Doctorow does note that the real names policy being enforced by Google Plus would create quite a change compared to the traditional notion of people potentially having multiple yet separate identities. Lewis Carroll wrote fiction yet Charles Dodgson wrote mathematics textbooks...even though both happened to be the same physical person.
(h/t Richard M. Stallman & Bradley Kuhn)
As much as I like Doctorow sometimes, this is a pretty weak essay (not that I can do any better!), but I do like his close: "There could be no stupider moment for Google to subscribe to the gospel of Zuckerberg, and there is no better time for Google to show us an alternative."
I wish I could come up with a reason that'll force me to pick sides here, I'm still on the fence of this debate.
I took a side
I wound up deleting my Google Plus account because it was a pain to keep up with let alone post to. The gopherspace hosted by Super Dimensional Fortress is far more flexible let alone Identica.
Whenever I can figure out how to keep StatusNet up without making a whole shared server fall over I probably will go back to that.
Superman vs. Google Plus
In my case
the very fact that I couldn't join up when it started has massively put me off wanting to join and now reading and hearing about all these elements has made me really not care.
I would have joined up, so they've lost one person here. I wonder how many people think the same?


text:
Irish Internet Radio and TV from Dublin, Ireland.
This is my dog, Bear! He's smiling! :-)
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text:
Luxury Beauty Gifts That Sparkle
The holidays have arrived and in true NewBeauty fashion, we've lined up some of the most luxurious gifts you can get for the beauty lovers in your life. Best of all, each one of these gifts pack so much sparkle and shine, you just might want to run out and buy them for yourself.
From diamond eyelashes and sparkling tweezers to 24c gold leaf nail polish, this ultimate luxury gift guide will thrill anyone on your list. Watch this video to find out what the most beautiful presents are this year and share it with your loved ones to drop some hints of your own.
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Those eyelashes are gorg! A bit pricey for a few wears though
Posted on1
More articles on Tips + Tutorials, Moisturizers, Sparse Eyelashes, and Hands + Nails:


text:
Additional Financial Aid Opportunities for Teachers
Browse the following links for more opportunities:
Teacher Education Assistance for College and Higher Education (TEACH) Grant Program
Invest in Teachers Scholarship
91 Killian Bldg. Ln., Suite 205
Cullowhee, NC 28723
828.227.7027 tel
828.227.7090 fax
Most of Western's alternative licensure programs are available as Distance Learning Programs (DLP) because courses are held off-site or online. Tuition for distance learning programs is calculated by credit hour. We also offer residential courses allowing you to take classes at our Cullowhee campus or on the campus of the University of North Carolina at Asheville. Graduate resident tuition is based on a full-time or part-time status. Undergraduate resident tuition rates are based on full-time status. To see how individual programs are offered, please visit our Alternative Licensure Programs.
Visit WCU Tuition and Fees for detailed information regarding tuition for the upcoming semesters.
In addition to tuition and university fees, you'll need to factor other costs of attendance into your graduate school budget. These may include incidental costs such as TaskStream, transportation, books, and supplies. Visit Financial Aid for more information.
Information for Out-of-State Students
Out-of-state students need to visit WCU's Applicants Outside NC to view eligibility of online programs.
Establishing North Carolina Residency
You must complete the North Carolina Residence and Tuition Status Application (PDF) to establish North Carolina residency. Contact Elizabeth Frazier (firstname.lastname@example.com or 828-227-3179) if you have questions.


text:
As a result, Cell Cycle ,SIRT pathway inhibitors may possibly use the two COX- 2-dependent and COX-2-independent mechanisms to mediate their antitumor properties, although their relative Mobile CYCLE contributions towards the in vivo consequences stay considerably less crystal clear. Sorafenib, is a multikinase inhibitor, which in addition to concentrating on Raf kinases also inhibits VEGFR-2/-three, SIRTUIN-, Flt-3 and do-Kit.
On the foundation of the latest huge randomized section Sirtuin III examine, the Sorafenib HCC Assessment Randomized Protocol, Sorafenib has been accredited by the United States Food items and Drug Administration for the treatment of patients with sophisticated HCC. In the SHARP demo median total survival increased from 7.9 months in the placebo team to ten.7 months in the sorafenib group. Sorafenib confirmed a important advantage also in phrases of time to progression, with a median of five.five months in the sorafenib team and two.eight months in the placebo team. On the foundation of these conclusions, the FDA, European Medicine Company and other regulatory authorities in the planet have accredited sorafenib for innovative HCC treatment method. Nonetheless, although sorafenib is properly tolerated, problem for its safety has been expressed.
Most widespread adverse activities reported in the SHARP test have been diarrhea and hand-foot epidermis reactions. Sorafenib is currently going through investigation in a section III examine - the STORM demo - in HCC patients as an adjuvant therapy for the avoidance of recurrence following surgical treatment or local ablation. In addition to sorafenib Cell CYCLE other molecular concentrating on agents have been utilised in scientific trials for superior HCC treatment. Even so, most of them have demonstrated very reduced responses. The reduced response charge linked with monotherapy implies the require to discover mixtures of diverse molecular focusing on agents, but also mixtures of a single agent with conventional cytotoxic medications. Sirtuin In this context, a section II demo demonstrated that the addition of sorafenib to doxorubicin improves progression-free and overall survival of clients with superior HCC.
Additionally, a stage II test is at present recruiting patients to determine the progression-cost-free survival of sorafenib additionally tegafur/ uracil for the treatment of superior or metastatic HCC. In addition to Raf inhibition, preclinical research have demonstrated the likely of MEK inhibition Cell CYCLE to suppress hepatoma cell proliferation and tumorigenicity. Huynh et al. recently noted that therapy of human HCC xenografts with AZD6244, a selective MEK inhibitor, blocked ERK1/2 activation, reduced in vivo tumor expansion and induced apoptosis. Focusing on MEK with the selective MEK inhibitor PD0325901, a derivative of CI-1040, experienced in vivo chemopreventive consequences on HCC development in an bestial model using TGF--transgenic mice with liver cancers induced by diethylnitrosamine treatment method.
In addition, a mixture of the MEK inhibitor AZD6244 and the conventional cytostatic drug doxorubicin enhanced the antineoplastic action Sirtuin of the respective monotherapeutic HCC therapy with doxorubicin on your own. MEK inhibitors have also been demonstrated to potentiate the antitumor activity of selective COX-one and COX-two inhibitors in suppressing progress and inducing apoptosis in human liver most cancers cells. Taken jointly, the in vitro and preclinical in vivo data demonstrate that MEK inhibitors are promising brokers for HCC treatment method. However, a multicenter section II medical review failed to exhibit a scientific gain for AZD6244 as a simple agent in patients with sophisticated HCC.
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Forum | Topic | Date | Replies |
Vegetarian | 100 Calorie Vegan Snacks/Meals | Sep 15 2012 19:45 (UTC) |
5 |
Smoothies I like smoothie's try an apple an cinnamon smoothie in almond or another plant milk. So scrummy!! | |||
Vegetarian | 100 Calorie Vegan Snacks/Meals | Sep 15 2012 19:45 (UTC) |
6 |
Smoothies I like smoothie's try an apple an cinnamon smoothie in almond or another plant milk. So scrummy!! | |||
Vegetarian | vegitarian all my life but want to be Vegan | Sep 15 2012 17:11 (UTC) |
4 |
:) Do some research buy a few good books I recommenced buy the book 100 best health foods it's a vegan book per say but 88 of the foods are vegan. It's helping me greatly plan meals It gives the Nutrition value of each food including protein, calcium,fibre, calories etc. Also buy a couple of vegan books, a couple of apps or e.books. I decided to go vegan about a month ago ;) I just went ahead and researched like mad. Now I get about 46-69grams of vegan protein per day 600-700mg of vegan calcium which is the UK rda. And all my fibre and all my vitamins too.. Yeast extract is vegan b12, many cereals and breads are fortified with b12 too. Leafy greens like spinach have iron in them. Do some in-depth research and get all the info you need b4 you switch ;) once you got the knowledge, facts and find vegan food stuffs in your area it's easy. At first it's hard thou but gradually gets easier ;) | |||
Vegetarian | Pets | Sep 15 2012 16:55 (UTC) |
10 |
It varies from person to person, I have one cat and two budgies been mostly veggie for 6yrs with the occasional meat dish. Recently curving a lot more to the the vegan side cutting out all meat, eggs, milk and cheese. I personally see nothing wrong with having a pet it depends how you go about it. You could go and buy a puppy which has been raised in a puppy farm, treated like crap and support the pet industry or you could go to the shelters or pound and give a dog a second chance of having a lovely home. Considering the pound is going to put the dog to sleep you could spare it and show it kindness and a happy life. ^.^ thats my opinion any way. | |||
Fitness | Having a hard time excersizing at all due to back problems! | Jun 29 2012 12:44 (UTC) |
7 |
Damn just read more 0.0 holy hell bad wolfie must read full threads. Anyhoo have you tried heat relief pads? U can wear them all day to try n ease pain hun. I hope you find a solution hun. | |||
Fitness | Having a hard time excersizing at all due to back problems! | Jun 29 2012 12:42 (UTC) |
8 |
Swimming gia :D or water aerobic :D very good exercise and works the whole body. Biking is good too but needs work to keep posture right. Dnt slouch. Have you had anyone look at ur back? I had problems years ago anyhoo I did some physio therapy that helped and now I note my posture. I walk alot which is good. If you need to pick things up bend ur knees not ur back. Posture is key when it come to back. Try adapting how u stand, sit, walk imagine you have a rod or ruler holding ur back up straight. Take time to adjust but soon becomes nature to keep a good posture. If need be a new mattress may do wonders as how sleep can also trigger back pain ^.^ hope that helps | |||
Motivation | size 0 beautiful? | Jun 29 2012 12:36 (UTC) |
1 |
Gia it's all good sweetie :D 0.o ur right to feel under attack hun. It's my own fault for not wording things right. Doh guess I'll think b4 I type next time. No harm no foul. Keep smiling be happy hun | |||
Weight Loss | How do I block out my fast food cravings?? | Jun 29 2012 12:32 (UTC) |
2 |
Hi dana I agree with mac d's eeewwe *looks for a bucket* ur right pink slimee!! Anyhoo it's been 4yrs no mac d's yay!!! ^.^ ppl need to try and cook more. I recently started cooking and now I love it. It's just finding recipes that are easy to do ^.^ so if u want a burger make one instead if buying one. You'll be amazed how yummy and low cal homemade is. | |||
Weight Loss | Bad news, scale. You're not going to be happy with me in the morning. | Jun 29 2012 12:27 (UTC) |
1 |
It happens :D we all have those bad calorie days no worries keep smiling just get back on track the next day ^.^ | |||
Weight Loss | The best time to work out - in relation to meals | Jun 29 2012 12:25 (UTC) |
4 |
Me too I agree with smashly it's your body, your life you workout when you can fit in the time to workout | |||
Weight Loss | Weight lose in stomach only? | Jun 29 2012 12:23 (UTC) |
1 |
Nope you can't target weight lose, as pointed out you need to lose overall body fat. However you maybe able to flatten your belly by doing some toning/firming ab work. If you not getting enough fibre or water you could be bloated. Try increase your fibre to as my belly tends to bloat if Im not getting enough. ^.^ which may make ur belly look bigger. | |||
Weight Loss | I refuse to own scales! | Jun 28 2012 23:47 (UTC) |
1 |
Yer cool it's a really good way to check weight loss! Thank u :D I hadnt checked my weight for 2 weeks and was like what the 4 more lbs gone!! Yay | |||
Recipes | Substitute for White Wine? | Jun 28 2012 20:45 (UTC) |
3 |
Oh right u want to cook with it. Just take it out of the recipe. ð?? | |||
Recipes | Substitute for White Wine? | Jun 28 2012 20:44 (UTC) |
4 |
A good substitute for wine is water :D I dnt drink so thats my option | |||
Motivation | Someone motivate me to exercise... | Jun 28 2012 20:35 (UTC) |
45 |
Can I say that ;) Im a bit lazy so I do things I enjoy and want to actually do for pleasure ð?? | |||
Motivation | help? | Jun 28 2012 20:32 (UTC) |
3 |
Sarah without knowing some stats how can we help her? Anyhoo I get what ur saying so im making alternative suggestions | |||
Vegetarian | new veggies! | Jun 28 2012 20:29 (UTC) |
3 |
Thank you lysistrata! Thats was my whole point I was trying to make but somehow frapped about chicken *face palm* I hope i spelt ur user name right. ^.^ use to be a big meat eater now im just about veggie. | |||
Weight Loss | How do I block out my fast food cravings?? | Jun 28 2012 18:39 (UTC) |
5 |
Cook your own healthy versions or have food swaps of some sort. Since I started cooking more ive noticed what im putting in my food and thus whizz up very tasty but low cal/foods and this helps me keep my cravings at bay. Food swapping to is good, swap chocolate for weight watchers hot choc for instance 250 in a bar of choc whilst the hot choc is a mere 50 :D burgers swap them for homemade patties in pitta,chicken wings in batter swap for grilled chicken. It's all bout becoming treat wise :D and keeping it in moderation. Soda swap for sparkling water u can add some low cal cordial or even better lemon juice to. | |||
Weight Loss | The Weight Of Poo | Jun 28 2012 18:22 (UTC) |
2 |
A poo topic? O.o oh my ok heres my thought or what Ive heard any weight u may lose after a poo is temporary weight and there for as we eat the mass will come back. ^.^ there my 2cents | |||
Motivation | Is it normal to gain back weight that was lost slowly? | Jun 28 2012 18:18 (UTC) |
5 |
Good job you lost 85lbs :D con grates on that. Im happy for u |


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ABC Checklist 1
This the first of six extracts from The ABC Checklist for New Writers: How to Open Doors and Get Noticed the First Time Around by Lorraine Mace and Maureen Vincent-Northam, published by Orana Publishing at £10.99. This useful book gives succinct answers to the many problems writers face, making it an indispensable reference for the budding writer.
Agents — When and how to approach them
Plenty of authors have sold their books directly to a publisher, but there are a number of benefits in acquiring the services of an agent.
Agents are well informed about market trends, able to assess your work and offer it to the most suitable publisher. They will advise, check over your publishing contract and negotiate the best terms on your behalf.
So when is the right time to approach an agent and how do you go about it?
Not surprisingly, the most advantageous time to approach an agent is when a publisher shows an interest in your book – but before you sign a publishing contract.
Finding an agent:
Make a list of the agents you want to contact. Those who handle the type of book you have written, or are in the process of writing, are the ones to aim at. This can be done in a number of ways.
• Look in the acknowledgements sections of books in your chosen genre; the author often thanks a helpful agent
• The Bookseller, a weekly publication, gives key information about the book industry and often carries news about which agents have sold new books – make a note of the ones who seem to be handling books like yours
• Check the listings in the Writers' and Artists' Yearbook and The Writer's Handbook
• Attend writers' conferences where agents are booked as guest speakers
The approach:
Each agent has his or her preferred method of approach. A large number now have websites and some will accept submissions by email, but do check individual guidelines for exact requirements.
Many agents do not accept unsolicited manuscripts and prefer a query letter in the first instance. If an agent doesn't have a website, write to those on your list asking if you may submit work, enclosing a stamped addressed envelope for a reply. Ask the agent to confirm the submission requirements as these differ – some may want to see a detailed proposal, while others will also request a given number of chapters.
Your preliminary letter should be clear and to the point.
Explain why there is a need for your book and how the book meets that need. Mention any specific qualifications you have for writing your book and whether you can supply photographs to illustrate it.
Tell the agent that you intend to send your full book proposal to one agent at a time and invite them to contact you as soon as possible if they are interested. If you receive a favourable reply to your preliminary letter, mail your book proposal (and chapters if these were requested), enclosing return postage.
Sending your book proposal:
Submit your book proposal and chapters to one agent at a time, even if more than one responded to your initial query. Your cover letter should reiterate the fact that this is an exclusive submission.
On the envelope write 'Requested material' so the office knows this is not unsolicited work.
If you haven't heard from the agent within a reasonable time, you may wish to send your book proposal out to another agent who has shown an interest. Send a polite letter to the first agent explaining this, giving her the opportunity of contacting you if she is interested in your proposal.
If you hear nothing, send to the next agent on your list. An agent who rejects your proposal may sometimes tell you what they didn't like about it. This professional advice can be very useful; it may help you to improve your work by incorporating some of the new ideas.
Some publishers will only agree to look at work submitted by agents, knowing this work will be of a high standard, but it can be harder to find an agent than a publisher.
To summarise:
• Aim only at those agents who handle books in your field
• Send a preliminary letter in the first instance
• Submit your proposal to one agent at a time
• Take note of any professional advice an agent offers
This extract is published by kind permission of Orana Publishing.
© Lorraine Mace and Maureen Vincent-Northam
The ABC Checklist For New Writers
1: Agents - when and how to approach them
2: Editors - who they are and what they do
3: Keeping Records
4: Marketing
5: Professionalism
6: Titles
to buy the book
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This section contains 1,222 words (approx. 5 pages at 300 words per page) |
Critical Review by Richard Ellis
SOURCE: "Sturm und Drang," in Los Angeles Times Book Review, May 25, 1997, pp. 8-9.
[In the following review, Ellis lauds Junger's The Perfect Storm as "a wild ride that brilliantly captures the awesome power of the raging sea and the often futile attempts of humans to withstand it."]
In October 1991, Sebastian Junger was standing on the shore of Gloucester, Mass., as winds howled, waves crested at 100 feet, ships were overturned, rescues were effected, men died. In The Perfect Storm, he writes: "A mature hurricane is by far the most powerful event on Earth; the combined nuclear arsenals of the United States and the former Soviet Union don't contain enough energy to keep a hurricane going for one day. A typical hurricane encompasses a million cubic miles of atmosphere and could provide all the electric power needed by the United States for...
This section contains 1,222 words (approx. 5 pages at 300 words per page) |


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Weird Fantasies 14: Fun with Friends
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ShastaCounty.Com A GUIDE TO SHASTA COUNTY, CALIFORNIA |
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Search this site... SEARCH TOOLS: We added a whole page of search engines and search tools for your convenience. Would you like to contact a government official? Are you interested in the census information about your area? Do you need to know a zip code? Would you like a map for any area in the U.S.? Check out our Search Tools page, and have fun searching!www
www Redding Traffic Cameras: Live Click here for Shingletown events and links to their community websites. Northern Califonia Travel and Tourism Information Network: Wonderful pictures and info about Shasta County and surrounding regions! If you haven't checked MapQuest out yet, you're in for a real treat! Type in any address in the U.S. and get a detailed map of the surrounding area. Just print out the map and use it for directions to your home, business, or traveling. Great for parties, meetings, stationary, etc.
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God Bless America! Check out these excellent links to more information about Shasta County: Shasta County, California This is the official government site for Shasta County. Click here for information on all the County departments and services. California Travel & Tourism: California's official source of travel and tourism information. Northern California Parks: Take a look at Ahjumawi Springs... Burney Falls... Castle Crags and Shasta Historic Park ~ especially if you're interested in beautiful scenery and camping. City of Redding The city's official web site...chockfull of good information! Viva Downtown Redding Check here for details on Viva's exciting annual events drawing attention and people to downtown Redding. City of Anderson A guide to the city of Anderson ...including such topics as: City Departments; Parks & Recreation; Police; as well as other informative links Anderson Chamber of Commerce The Anderson Chamber of Commerce is dedicated to building successful businesses in the Anderson and surrounding areas. |
Some Notes on Shasta County Shasta County is the economic, cultural, and geographical center of the northern section of the State of California. The City of Redding is the county seat for Shasta County. Redding is the county's largest city with a population in excess of 70,000. The cities of Anderson and Cottonwood are located directly to the south of the City of Redding. The newly incorporated City of Shasta Lake is located directly to the north. The topography ranges from the flat valley area in and around the City of Redding, which is about 300 to 500 feet above sea level to Lassen Peak that reaches to the height of 10,455 feet above sea level. Shasta County has the unique distinction of having three different mountain ranges flow into the county. The Sierra Nevada Mountains are located in the eastern section of the county, while the Cascade Mountain range is in the north county and the Coastal Mountain range is located in the western county. Most visitors find it striking that one can view the snow-capped Trinity Alps, Mount Shasta and Lassen Peak from almost any location in and around the general Redding area. The shoreline of Shasta Lake, located just a few miles north of Redding, seems almost endless. Beautiful clear blue waters of Shasta Lake offer all forms of boating enjoyment. Numerous secluded coves offer peace and quiet for those enjoying one of hundreds of fully-equipped houseboats available to rent. Fishing is available county wide. Shasta County has numerous creeks, streams, lakes and rivers for fishing. For the lazy fishermen there are hundreds of spots that have easy drive-up access. For the more fit, there are exclusive native trout areas that are located in the non-vehicle wilderness areas. The Shasta Caverns are located on Lake Shasta. A unique boat-in tour will provide you with memories of magnificent underground cathedrals formed by the timeless process of mineral accumulation. Redding is also a cultural and entertainment center for Northern California and southern Oregon. Check Arts & Crafts for local links. |
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A historic place in Northern California...a great place to be! |
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MADRID (Reuters) - Real Madrid players have suffered more racist abuse than those from other clubs, midfielder Jose Callejon said on Friday after Barcelona's Brazilian fullback Daniel Alves complained of monkey chants in Wednesday's King's Cup semi-final at the Bernabeu.
Alves said on Thursday Spain was a "lost war" when it came to tackling racism and called for stiffer punishments for clubs whose fans abused opposition players.
"The only club that has suffered a lot of insults throughout its history is Real Madrid," Callejon told a news conference previewing Saturday's La Liga match at Granada when asked about the Alves remarks.
"We always go to play in very difficult stadiums and there have been players, and right now there are players, who are being insulted for this issue (racism)," he added.
"It's an issue you can't control which also happens in Spain and in other countries. I think it's a bit unfortunate."
A Reuters reporter at the Bernabeu on Wednesday confirmed monkey chants had been directed several times at Alves by a significant section of the Real fans.
The referee did not mention them in his match report.
There have been several high-profile incidents of racist abuse in European soccer in recent weeks despite efforts by the governing body UEFA to stamp it out.
AC Milan midfielder Kevin-Prince Boateng led his team off the pitch during a friendly at Italian lower division side Pro Patria last month in protest at chanting by the home fans and the game was abandoned.
"We saw the racist insults directed at Boateng in Italy and it's a worrying issue," Callejon said.
"It is not pleasing that these insults are made and let's see if they will stop once and for all."
Callejon also confirmed that there had been an altercation between assistant Real coach Aitor Karanka and Barca forward Lionel Messi after Wednesday's semi-final first leg, which ended in a 1-1 draw.
Media reports which said Messi called Karanka "Mourinho's puppet" were correct, Callejon added.
A former Real player, Karanka often stands in for coach Jose Mourinho at news conferences.
"I saw what happened with Aitor because I was behind him," Callejon said.
"I think that sometimes the 'good ones' are not so good and the 'bad ones' not always so bad."
Real, whose title defence has faltered leaving them 15 points behind leaders Barca, can close to within a point of second-placed Atletico Madrid with a win at Granada (2100 GMT).
Barca play at Valencia (1800) and Atletico host Real Betis on Sunday (2000). (Additional reporting by Silvio Castellanos, writing Iain Rogers, editing by Pritha Sarkar)
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Get the latest news on the go. Visit Reuters India on your mobile device Full Coverage


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This is the January 14, 2013 news archive. View today's Wisconsin Sports rumors and news.
Nyjer Morgan Got Caught Cheating On His Girlfriend, According To Nyjer Morgan's Twitter Account
Updated Jan 14, 2013
We pretty much know as much as you do on this one. All we have to go on are the exclusive details that were posted in the free agent outfielder's timeline in the last half hour or so. Well, that and Morgan's avatar now appears to show him kissing the wo…
Gallardo, Maldonado slated to play in Classic
MLB.com Jan 14, 2013Mexican-born Brewers right-hander Yovani Gallardo and catcher Martin Maldonado of Puerto Rico are expected to appear later this week on their homelands' preliminary rosters for the World Baseball Classic, separate sources said.Share TweetChiefs introduce Dorsey as general manager
ESPN.com Jan 14, 2013John Dorsey called becoming the general manager of the Kansas City Chiefs the "perfect storm." The word "serendipity" may have been more appropriate.Share TweetCracking Down on Malevolence at Candlestick
nytimes.com Jan 14, 2013Fan behavior in San Francisco has led to an increased police presence at 49ers games; 92 people were ejected from the game against the Packers on Saturday.Share TweetBucks' Jennings, Thunders' Durant named Players of Week
nba.com Jan 14, 2013The Milwaukee Bucks' Brandon Jennings and the Oklahoma City Thunder's Kevin Durant on Monday were named Eastern and Western Conference Players of the Week, respectively, for games played Monday, Jan. 7 through Sunday, Jan. 13.Share TweetBest N.B.A. Games of the Week
nytimes.com Jan 14, 2013Best N.B.A. games this week pit the Lakers and Bucks, the Rockets and Pacers and the Warriors vs. the Spurs.Share TweetFree Head Exam: Green Bay Packers
ESPN.com Jan 14, 2013After the Green Bay Packers' 45-31 loss to the San Francisco 49ers, here are three issues that merit further examination: We utilized plenty of cyberspace discussing a defense that allowed 323 rushing yards, and a total of 571 offensive yards in the los…Share TweetJermichael Finley: Hopefully, I'm here forever
profootballtalk.com Jan 14, 2013The end of the Packers season accelerated thinking about whether or not wide receivers Donald Driver and Greg Jennings would return to the team for the 2013 season. They aren't the only Aaron Rodgers targets with an uncertain future in Green Bay. TightShare TweetLeading Off: Can Anyone Stop These Guys?
nytimes.com Jan 14, 2013The sum total of the weekend's four N.F.L. games: 3,598 yards, 35 touchdowns and that whole defense-wins-championships canard takes one right in the kisser.Share Tweet2013 NFL draft order: Packers at No. 26
ESPN.com Jan 14, 2013Thanks to NFC West blogger Mike Sando for passing along this chart of as much of the 2013 draft order as we can get at the moment, with four teams remaining in postseason play. As you can see, the NFC North has the No. 5, the No. 20, the No. 23 and the …Share TweetDivisional playoff MVPs: Quarterbacks come through with big performances
yahoo.com Jan 14, 2013Colin Kaepernick, quarterback, San Francisco 49ers: Much of the talk in the week leading up to the 49ers' divisional playoff game against the Green Bay Packers centered on how Kaepernick would handle his first playoff game in the NFL. After all, Alex Sm…Share TweetWe Went There: 49ers-Packers
grantland.com Jan 14, 2013Kevin Greene walked through the tunnel, hands in pockets, eyes fixed on his feet. As some players jogged and some players sulked, the coach of the Pac...Share TweetAbout Last Weekend: Kaepernick Runs Over Packers
grantland.com Jan 14, 2013In case you were busy trying to concoct a homemade flu vaccine out of common household spices, here's what you missed in sports last weekend. The Sa...Share TweetSports Columnists
NFL mailbag -- Running QBs have leg up, for now
Jan 14The pistol and read option have staying power, but defenses will eventually adjust. Plus, reader questions. -
Peter King: Offensive outburst, meeting of legends set up conference final…
Jan 14DENVER -- Ray Lewis was sick Saturday night, 90 minutes after the Ravens had stunned the Broncos here, and he was waiting in a stadium anteroom to be connected with Deion Sanders for an NFL Network interview. "Flu?'' someone asked him. He nodded in…


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Skullcandy at Freestyle.ch
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Halldor and PLG topping the podium, break dance battles, Lil Jon, Danny and Dingo, Tanner Hall, Halldor in the photobooth, skull stamps, swag????? Freestyle.ch in Zurich, Switzerland was raging! The skull has officially arrived in Europe.
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WALNUT CREEK, Calif.An international team led by scientists from the U.S. Department of Energy (DOE) Joint Genome Institute (JGI) and the U.S. Department of Agriculture Forest Service, Forest Products Laboratory (FPL) have translated the genetic code that explains the complex biochemical machinery making brown-rot fungi uniquely destructive to wood. The same processes that provide easier access to the energy-rich sugar molecules bound up in the plant's tenacious architecture are leading to innovations for the biofuels industry. The research, conducted by more than 50 authors, is reported in the February 4 online edition of the Proceedings of the National Academy of Sciences (PNAS).
Among the challenges to more cost-effective production of biofuels from cellulosic biomassthe fibrous material of whole plantsis to find effective means to work around the polymer lignin, the scaffolding that endows the plant's architecture with rigidity and protection from pests. By doing so, the organic compound cellulosethe long chain of glucose (sugar) units can be unbound, broken down, fermented, and distilled into liquid transportation fuel. This is where the destructive capabilities of rot come in.
"The microbial world represents a little explored yet bountiful resource for enzymes that can play a central role in the deconstruction of plant biomassan early step in biofuel production," said Eddy Rubin, Director of the DOE JGI, where the genome sequencing was conducted. "The brown-rot Postia placenta's genome offers us a detailed inventory of the biomass-degrading enzymes that this and other fungi possess."
Rubin pointed to a complementary strategy that DOE and its Bioenergy Research Centers are pursuing of targeting a new generation of plantsperennial grasses and fast-growing trees such as poplarbred specifically as biomass for biofuels. Among the desirable characteristics of biofuel "feedstocks" is the ease by which they can b
Contact: David Gilbert firstname.lastname@example.com 925-296-5643 DOE/Joint Genome Institute Source:Eurekalert |


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It's the middle of the afternoon. Your stomach is grumbling, and you could swear the vending machine is humming your name. So now you're debating: chocolate bar or potato chips? Cheese crackers or mini-bag of cookies? You're leaving with something, but you don't want to derail your diet.One day soon, the decision may not be so hard: Vending machines offering healthier fare — yogurt, fruit crisps, energy bars — are sprouting up. But for now, if you find yourself in front of a machine, choose these snacks that provide nutrition, not just calories:Peanuts or almonds. They are a good source of protein and fiber, so you'll feel fuller longer. They also provide vitamins and minerals, as well as healthy fats, which may help lower cholesterol levels. The downside: Nuts are high in calories, so watch your portions.Pretzels. Compared with potato chips, they have fewer calories and less fat: 1 ounce of pretzels has 108 calories and less than 1 gram fat; chips have 154 calories and more than 10 grams fat. But pretzels lose in the sodium department, packing 385mg an ounce vs. chips' 136mg. Choose unsalted or whole-grain if available.Popcorn. Fat-free or reduced-fat, air-popped popcorn is the healthiest option. It adds fiber to your diet for very few calories. Even if a ready-made bag says "air-popped," check the label for total fat, saturated fat and trans fat (do the same for microwave popcorn). Oil may be added for flavor, which boosts fat.Crackers & peanut butter. The combination of fiber and complex carbohydrates in whole-wheat crackers and the protein in peanut butter will boost your energy.Dried fruit. It contains the same nutritional value as fresh fruit (with the possible exception of fiber) but may be higher in calories (1/2 cup of dried is about the same as 1 cup whole). Raisins, cranberries and apricots often are dried with little or no added sugar.— The Doctors is an Emmy-winning daytime TV show with pediatrician Jim Sears, OB-GYN Lisa Masterson, ER physician Travis Stork, and plastic surgeon Andrew Ordon. Check www.thedoctorstv.com for local listings.
- 'True Squallywood legend' | Tahoe photographer beginning road to recovery after spinal cord injury
- Woman, 61, suspected of embezzling $850,000 from Lake Tahoe business
- North Tahoe crime logs: Man, woman fight over food, who pooped in bathtub
- Tahoe's Sand Harbor boat ramp won't launch for 2015; others will open
- Maloff presents Barton with $10 million check


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Hardware Reviews
iPad Air 2 – Taking The iPad To New Places
October 24, 2014 -The iPad Air was a substantial advancement for the iPad line offering a thinner, lighter, and faster version. A year later, we have the iPad Air 2, which builds upon a great base, and still… Read More »
iPhone 6 – This iPhone Is Just Right
September 23, 2014 -Apple has released a new iPhone every year since 2007, but 2014 is different. This year, Apple released two new iPhones with the 6, and 6 Plus, offering either a 4.7", or 5.5" screen. This… Read More »
iPad Air – Light Speed Ahead
November 4, 2013 -Apple created an all new wave of tablets in March of 2010 with the release of the first iPad. Five generations later, the device maintains many of the same attributes, while Apple continues to try… Read More »
iPhone 5 – A Brilliant Refining Process Of Every Aspect
September 24, 2012 -Apple has offered a new phone every year since 2007, and yet when you look at the first iPhone and the iPhone 5, there's not that much difference. Each new generation refines the overall piece… Read More »
The New iPad (3rd Generation) – I Can See Clearly Now
March 20, 2012 -After months of speculation, the new iPad has finally arrived, and it it's pretty much as expected. The real question is, if it's worth the cost either for first time buyers, or upgrades from existing… Read More »
New Apple TV 1080P – An Essential iOS Accessory
March 19, 2012 -Along with the new iPad, Apple launched the new Apple TV to considerably less fanfare. Still though, it's a nice upgrade that finally brings 1080P to Apple's little black video streaming box. The device is… Read More »
iPhone 4S – S Is For Speed, Shots, And Siri
October 18, 2011 -The iPhone 4S is Apple's fifth major version of their flagship device, and with it comes a number of enhancements, all on the inside. The iPhone 4S features the same design as the iPhone 4… Read More »
The Magic Charger – For Magic Mouse
August 3, 2011 -If you've ever used a wireless Magic Mouse, then you know it eats through batteries faster than a mouse eats through cheese. It seems like you're always getting the alert on your computer that your… Read More »
13″ MacBook Air – Sandy Bridge, Thunderbolt, Mid-2011
August 1, 2011 -The MacBook Air has gone through quite a transformation as a product since its original release on January 29th, 2008. It was originally released as the world's thinnest notebook that could fit inside a manilla… Read More »


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© 2011 Caron International
© 2011 Caron International
Flea Market Bag
This pattern is
available for free.
The parade of Sheep(ish) projects continues with Linda Permann's useful and lovely Flea Market Bag. Crocheted in a yummy shade of Vickie Howell's new washable, wool-blend Sheep(ish) yarn, this earth-friendly tote will hold your attention and your goodies.
Gauge info from pattern: Rounds 1–5 measure about 5"/12.5cm wide;
For more information, see:


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26-10-2012 04:31
Does anyone know how to sign out with the new Skype app?
I signed in with an old Skype account and connected it with my Microsoft account.
1. I want to sign out.
2. I want to disconnect my Microsoft account with the old Skype account.
Any help?
26-10-2012 04:46
IF you are using a Microsoft Account to log in to Windows 8, then Skype consumes this account, and this is also the account you connected Skype to.
Unfortunately there is no log-out option. The only way to log out of Skype would be to disable background running and notifications and quit the app. Or other possibility would be to use a local account to log in to Windows 8.
Currently the account unlinking can be done by customer support only. Please file a request to them. You can find out how to do it here: https://support.skype.com/en/faq/FA1170/how-can-i-
26-10-2012 06:15
I m already using local account, but still cannot sign out, how come?
I put in a MS account when 1st login thou.
26-10-2012 07:15
If you are on a local account, then the Log Out button is located under Settings charm -> Options. (the same place where you can select audio and video device)
27-10-2012 14:55
good, thanks heaps
It is just too hidden. I think need to put tutorial how to logout


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What's in the box? Dead Rising 2 High Stakes Edition Capcom sent me a little present today. It's the "High Stakes Edition" of Dead Rising 2. And now you can watch a video in which I show you all the things that come inside it in dazzling color. I'm really impressed with the package, actually. The parts are of surprisingly good quality. When you've seen as many crappy sets of poker chips as I did in five years selling board games, you come to appreciate a good one. They aren't clay, but still a very strong showing. If you shelled out the extra cash for this special edition, I think you'll be happy. So, who's getting it? Comments not appearing? Anti-virus apps like Avast or some browser extensions can cause this. Easy fix: Add [*].disqus.com to your software's white list. Tada! Happy comments time again.
Did you know? You can now get daily or weekly email notifications when humans reply to your comments.


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Article Index | Summary | Author Bio | Book Reviews | Discussion Questions | Full Version |
The Paris Wife
Paula McLain, 2011
Random House
320 pp.
A deeply evocative story of ambition and betrayal, The Paris Wife captures a remarkable period of time and a love affair between two unforgettable people: Ernest Hemingway and his wife Hadley.
Chicago, 1920: Hadley Richardson is a quiet twenty-eight-year-old who has all but given up on love and happiness—until she meets Ernest Hemingway and her life changes forever. Following a whirlwind courtship and wedding, the pair set sail for Paris, where they become the golden couple in a lively and volatile group—the fabled "Lost Generation"—that includes Gertrude Stein, Ezra Pound, and F. Scott and Zelda Fitzgerald.
Though deeply in love, the Hemingways are ill prepared for the hard-drinking and fast-living life of Jazz Age Paris, which hardly values traditional notions of family and monogamy. Surrounded by beautiful women and competing egos, Ernest struggles to find the voice that will earn him a place in history, pouring all the richness and intensity of his life with Hadley and their circle of friends into the novel that will become The Sun Also Rises. Hadley, meanwhile, strives to hold on to her sense of self as the demands of life with Ernest grow costly and her roles as wife, friend, and muse become more challenging. Despite their extraordinary bond, they eventually find themselves facing the ultimate crisis of their marriage—a deception that will lead to the unraveling of everything they've fought so hard for.
A heartbreaking portrayal of love and torn loyalty, The Paris Wife is all the more poignant because we know that, in the end, Hemingway wrote that he would rather have died than fallen in love with anyone but Hadley. (From the publisher.)
Author Bio
Paula McLain received an MFA in poetry from the University of Michigan and has been a resident of Yaddo and the MacDowell Colony. She is the author of two collections of poetry, as well as a memoir, Like Family, and the novels, A Ticket to Ride (2008) and The Paris Wife (2011). She lives in Cleveland, Ohio, with her family. (From the publisher.)
Book Reviews
McLain's novel not only gives Hadley a voice, but one that seems authentic and admirable.... A certain amount of bravery is required in writing a novel that channels a giant of American literature. Yet McLain pulls it off convincingly, conveying Hemingway's interior life and his profound struggles. She makes a compelling case that Hadley was a crucial (and long-lasting) influence on Hemingway's writing life: a partner as well as a cheerleader. She also revisits, with remarkable detail, a singular era in history, one that would produce some of the greatest literary works of the 20th century.
Novelist and memoirist Paula McLain traces the life of Hadley Hemingway, first wife of Ernest Hemingway, in this evocative novel set largely in Paris in the Jazz Age.
Christian Science Monitor
Written much in the style of Nancy Horan's Loving Frank ... Paula McLain's fictional account of Hemingway's first marriage beautifully captures the sense of despair and faint hope that pervaded the era and their marriage.
Associated Press
Engrossing and heartbreaking.... McLain is masterful at mining Hadley's confusion and pain, her crushing realization that she cannot fight for a love that has already disappeared.
Cleveland Plain Dealer
McLain smartly explores Hadley's ambivalence about her role as supportive wife to a budding genius.... Women and book groups are going to eat up this novel.
USA Today
By making the ordinary come to life, McLain has written a beautiful portrait of being in Paris in the glittering 1920s—as a wife and one's own woman.... McLain's vivid, clear-voiced novel is a conjecture, an act of imaginary autobiography on the part of the author. Yet her biographical and geographical research is so deep, and her empathy for the real Hadley Richardson so forthright (without being intrusively femme partisan), that the account reads as very real indeed.
Entertainment Weely
Told in the voice of Ernest Hemingway's first wife, The Paris Wife, by Paula McLain, is a richly imagined portrait of bohemian 1920s Paris, and of America literature's original bad boy.
Town & Country
Written much in the style of Nancy Horan's Loving Frank ... Paula McLain's fictional account of Hemingway's first marriage beautifully captures the sense of despair and faint hope that pervaded the era and their marriage.
McLain offers a vivid addition to the complex-woman-behind-the-legendary-man genre, bringing Ernest Hemingway and his first wife, Hadley Richardson, to life.... The heart of the story—Ernest and Hadley's relationship—gets an honest reckoning, most notably the waves of elation and despair that pull them apart.
Publishers Weekly
Though eventually a woman scorned, Hadley is able to acknowledge without rancor or bitterness that "Hem" had "helped me to see what I really was and what I could do." Much more than a woman-behind-the-man homage, this beautifully crafted tale is an unsentimental tribute to a woman who acted with grace and strength as her marriage crumbled. —Margaret Flanagan
Discussion Questions
1. In many ways, Hadley's girlhood in St. Louis was a difficult and repressive experience. How do her early years prepare her to meet and fall in love with Ernest? What does life with Ernest offer her that she hasn't encountered before? What are the risks?
2. Hadley and Ernest don't get a lot of encouragement from their friends and family when they decided to marry. What seems to draw the two together? What are some of the strengths of their initial attraction and partnership? The challenges?
3. The Ernest Hemingway we meet in The Paris Wife—through Hadley's eyes—is in many ways different from the ways we imagine him when faced with the largeness of his later persona. What do you see as his character strengths? Can you see what Hadley saw in him?
4. The Hemingways spontaneously opt for Paris over Rome when they get key advice from Sherwood Anderson. What was life like for them when they first arrived? How did Hadley's initial feelings about Paris differ from Ernest's and why?
5. Throughout The Paris Wife, Hadley refers to herself as "Victorian" as opposed to "modern." What are some of the
ways she doesn't feel like she fits into life in bohemian Paris? How does this impact her relationship with Ernest? Her self-esteem? What are some of the ways Hadley's "old-fashioned" quality can be seen as a strength and not a weakness?
6. Hadley and Ernest's marriage survived for many years in Jazz-Age Paris, an environment that had very little patience for monogamy and other traditional values. What in their relationship seems to sustain them? How does their marriage differ from those around them? Pound's and Shakespeare's? Scott and Zelda's?
7. Most of The Paris Wife is written in Hadley's voice, but a few select passages come to us from Ernest's point of view. What impact does getting Ernest's perspective have on our understanding of their marriage? How does it affect your ability to understand him and his motivations in general?
8. What was the role of literary spouses in 1920's Paris? How is Hadley challenged and restricted by her gender? Would those restrictions have changed if she had been an artist and not merely a "wife"?
9. At one point, Ezra Pound warns Hadley that it would be a dire mistake to let parenthood change Ernest. Is there a nugget of truth behind his concern? What are some of the ways Ernest is changed by Bumby's birth? What about Hadley? What does motherhood bring to her life, for better or worse?
10. One of the most wrenching scenes in the book is when Hadley loses a valise containing all of Ernest's work to date. What kind of turning point does this mark for the Hemingway's marriage? Do you think Ernest ever forgives her?
11. When the couple moves to Toronto to have Bumby, Ernest tries his best to stick it out with a regular "nine-to-five" reporter's job, and yet he ultimately finds this impossible. Why is life in Toronto so difficult for Ernest? Why does Hadley agree to go back to Paris earlier than they planned, even though she doesn't know how they'll make it financially? How does she benefit from supporting his decision to make a go at writing only fiction?
12. Hadley and Ernest had similar upbringings in many ways. What are the parallels, and how do these affect the choices Hadley makes as a wife and mother?
13. In The Paris Wife, when Ernest receives his contract for In Our Time, Hadley says, "He would never again be unknown. We would never again be this happy." How did fame affect Ernest and his relationship with Hadley?
14. The Sun Also Rises is drawn from the Hemingways' real-life experiences with bullfighting in Spain. Ernest and his friends are clearly present in the book, but Hadley is not. Why? In what ways do you think Hadley is instrumental to the book regardless, and to Ernest's career in general?
15. How does the time and place—Paris in the 20's—affect Ernest and Hadley's marriage? What impact does the war, for instance, have on the choices and behavior of the expatriate artists surrounding the Hemingways? Do you see Ernest changing in response to the world around him? How, and how does Hadley feel about those changes?
16. What was the nature of the relationship between Hadley and Pauline Pfeiffer? Were they legitimately friends? How do you see Pauline taking advantage of her intimate position in the Hemingway's life? Do you think Hadley is naive for not suspecting Pauline of having designs on Ernest earlier? Why or why not?
17. It seems as if Ernest tries to make his marriage work even after Pauline arrives on the scene. What would Hadley it have cost Hadley to stick it out with Ernest no matter what? Is there a way she could have fought harder for her marriage?
18. In many ways, Hadley is a very different person at the end of the novel than the girl who encounters Ernest by chance at a party. How do you understand her trajectory and transformation? Are there any ways she essentially doesn't change?
19.When Hemingway's biographer Carlos Baker interviewed Hadley Richardson near the end of her life, he expected her to b e bitter, and yet she persisted in describing Ernest as a "prince." How can she have continued to love and admire him after the way he hurt her?
20. Ernest Hemingway spent the last months of his life tenderly reliving his first marriage in the pages his memoir, A Moveable Feast. In fact, it was the last thing he wrote before his death. Do you think he realized what he'd truly lost with Hadley?
(Questions issued by publisher.)
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An exfoliating body scrub
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Unveil soft, radiant skin with this heavenly body scrub that exfoliates the skin and leaves it smooth and softly nourished. It leaves a sweet fragrance of rose petals, white carnation, cotton candy and vanilla musk. Keep it away from children, they might nibble on it.


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For years gold was belittled by government leaders, mainstream economists and traditional media as a derelict relic, of no real value and a risky investment prospect. But something funny happened a few years ago. Central banks worldwide, after decades of selling off their gold reserves, began buying it back. And for many months, even as far back as 2011, countries have quietly and not so quietly been working to repatriate their gold reserves. There is only one reason governments would ramp up efforts to accumulate gold: because those in power know the global fiat currency system is on its last legs. Ecuador's recent move to bring its gold home is just one more nail in the coffin of the world's reserve currency, the Federal Reserve's dollar.
In November 2011 Venezuelan President Hugo Chavez received the first shipment of gold from his request that 85% of the country's gold reserves be returned to Venezuela's central bank. As reported in a BBC story,
Romania has been trying to repatriate its gold from Russia since it asked Russia to keep it secure and out of the hands of the Germans during the first World War. Sadly, ever since sending its gold and other treasures to Russia, Romania has only received the art and artifacts, while Russia has resisted giving Romania back its gold. See Romania Wants Return of 93.4 Tons of Gold Repatriation Ratchets Up for more. Romania remains adamant:
Could it be the Russians aren't sure where Romania's original gold is, or just flat don't have it?
As we wrote in back in July, one of the 36 foreign central banks and institutions that have metal stored 80 feet underneath the streets of New York is the Swiss National Bank (SNB). Four members of the Swiss parliament launched "Rettet Unser Schweizer Gold: An Initiative to Secure the Swiss National Bank's Gold Reserves," which states that the Swiss people should have a right to vote on three simple things:
- Keeping the Swiss gold physically in Switzerland
- Forbidding the SNB from selling any more of its gold reserves
- The SNB has to hold at least 20% of its assets in gold
On the topic, CSLA's Chris Woods wrote that:
In a related story on GoldSilver.com, Guillermo Barba reported on Bank of Mexico disclosing that the gold they have bought was not physically acquired, but rather a claim against the Bank of England who will (hopefully) buy the physical gold and store it segregated on behalf of the Bank of Mexico. Presumably, Mexico's central bank purchased the gold with the intent of hedging against the potential collapse of paper money.
On October 22 we reported on Germany's plan to repatriate their gold slowly, bringing home 50 tons a year for 3 years. This move by Germany represents a bigger issue, however, and that is the push for a full-blown audit of the country's gold holdings. As reported on CNBC:
Could it be that Germany, like Venezuela and Ecuador, with a global monetary system increasingly vulnerable to loss of confidence and panic, has started to question the wisdom of storing its gold with the traditional custodians in London and New York? Has the German government simply become more cautious about accepting paper records of its gold holdings at face value without being able to lay eyes on their physical reserves? Most likely it is a combination of these and other factors that have caused the German government to push the central bank, Bundesbank, to take a more proactive role in validating the country's gold supply. Regardless of the reasons, Germany is definitely on track to audit its gold at the least and, more likely, to ultimately demand further repatriation.
In the Netherlands it is not the government demanding information about the nation's gold reserves; it is the citizenry. In a story dated October 25, the Gold Anti-Trust Action Committee (GATA.org) reported that:
What the story from the Netherlands tells us is that the concern about and interest in sovereign gold reserves is an issue that has escaped the walls of government and has reached into communities of concerned and engaged citizens. And, as any politician will tell you, once an issue attracts the attention of the population, it is not a subject that will simply disappear. In other words, when citizens demand action, politicians begin to listen, even if governmental bureaucrats drag their feet.
Finally, this nationalistic fervor for gold repatriation has reached tiny Ecuador, which recently joined the party by demanding that one-third of its foreign holdings be returned to in-country custody. Ecuador's gold claims amount to only 26.3 tons; nevertheless, its demand for repatriation of its gold, when combined with rumblings from Germany, Switzerland, Romania, and the Netherlands adds further emphasis to the emerging pattern.
With the exception of Germany, none of these countries' demand for repatriation could have a dramatic impact on the existing stores of gold. But they do signal the growing trend for gold repatriation and a growing consciousness that the global fiat currency and debt-addicted banking systems are reaching a breaking point. By reclaiming their physical gold and storing it securely, nations are securing their wealth and future survival—a strategy that should serve as a model for individuals as well.
Thanks for this informative discussion. I wonder how its in the U.S.
Could the people finally be getting pissed? Only time will tell…
I'm also busy here in the Netherlands:


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Bernard Kops:A Preliminary Inventory of His Papers at the Harry Ransom Humanities Research CenterScope and ContentsThis addition to the Bernard Kops collection at the Ransom Center includes drafts of published and unpublished plays, stories, and poetry as well as his autobiography Shalom Bomb; scenes from my life. Play titles include The Boy Who Wouldn't Play Jesus, Change for the Angel, The Dream of Peter Mann, Enter Solly Gold, Falling in Love Again, I Want to Go Home, and Stray Cats and Empty Bottles. Also included is correspondence with Lindsay Anderson, Michael Horovitz, Harold Innocent, Warren Mitchell, Olga Rudge, Arnold Wesker and others, and Kops's letters to his wife Erica. Books received with the collection were transferred to the Ransom Center Library. Return to the Table of Contents RestrictionsAvailability:Open for research Return to the Table of Contents Administrative InformationAcquisition:Purchase (Reg. no. 14679) Accessioned by:Liz Murray, 2001 Return to the Table of Contents Bernard Kops Papers--Folder List Return to the Table of Contents
Return to the Table of Contents |


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The Briar Patch is located in Queensbury, NY, in the Adirondack region of New York State. We have been active in the cavy fancy since 1983.
We show and breed teddies in solid golden, solid silver, black, red, roan, brindle and tan.
We are members of ARBA, ACBA, NRCF and MACBA.
Our Cavies * Tan Program * Champions
Contact * Links * Home


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I have an AS/400 at V5R2M0. I can ping the AS/400 by its NetServer name, but I cannot ping any PC in the network their by name. CXan this be done. What changes do I need to make. My goal is to refer to PC's in the network by name without having to add an entry to the AS/400 host name table.
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One site of our MPLS connections is down. When I do a traceroute to that site. I can see the packets bouncing back and forth between our router and the service provider's router. I haven't been able to contact the IT guys in the other site, so I'm trying to figure out what's happening from my side....
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Connecting multiple computers without a switch
How can I connect two PCs directly in same subnet to a router without using a switch? What kind of configuration would this be?
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VLAN connection problems over a switch
We have enabled interVLAN routing on a layer3 switch, but when we try to ping between one VLAN and other VLANs, only some of the PCs are able to ping and the rest are not. We have 6 VLANs and in all cases we are experiencing the same situation.
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