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Shorting Nektar (NASDAQ:NKTR) is a good investment. There are material deficiencies with lead asset NKTR-118, which I believe will result in the failure of this drug to achieve Phase III clinical trial primary endpoints. In the absence of positive results for NKTR-118, Nektar is worth very little (~$1 per share). Even if NKTR-118 succeeds, I don't think NKTR stock is worth $8 per share.
NKTR-118 is a mu-opioid receptor antagonist constipation drug with seemingly positive phase 2 data in opioid-induced constipation ("OIC"). Phase 3 results will be reported in Q4 2012 and this is a significant binary event for the company. I believe these phase 3 studies will fail. The reason for this is the unreliability of mu-opioid antagonists in eliciting a robust anti-constipation duration of effect in clinical trials. ALKS 37, Entereg, CB-5945 and PTI-901, all opioid antagonists, have failed to show a durable effect in long-term studies of constipation. All of these drugs show good short-term effects on constipation, but no drug has a long duration of action. Some of these drugs are FDA approved and to gain any share, NKTR-118 needs to show long-term (12 week) alleviation of opioid induced constipation. The one drug in this class to show a robust long-term response is oral methylnaltrexone (Relistor). This drug will likely be FDA approved this year, and Nektar and AstraZeneca will be playing "catch-up." The lack of efficacy at the low dose of the Relistor study illustrates that constipation studies, in general, are difficult to achieve success with. It will be hard for NKTR-118 to differentiate from Relistor, if it succeeds in the forthcoming pivotal trials.
The phase 2 results of NKTR-118 show a doubling in increased bowel movements at the target dose at 1 week. It is very important to note the primary endpoint is at just one week of therapy (there is some confusion that this was a four week endpoint). The clinical effect is small, with only one and a half increased bowel movements per week versus placebo. Indeed, this improvement is smaller than that seen with ALKS 37. Recall that ALKS 37, despite initial great short-term data, failed to replicate this effect in a longer study. Remember, these drugs are very similar, and the ALKS 37 experience illustrates why it is hard to trust replicating and extending initial OIC data with a mu-opioid receptor antagonist. At lower doses, NKTR-118 doesn't work well, and at only moderately higher doses is it too toxic (see the SAE). Finally, I'm not sure the improvement in bowel movements seen with NKTR-118 is clinically meaningful.
Constipation trials are very hard to run as the effect size of any drug is usually small with large variability in results. There are numerous other agents and non-medicinal physiological procedures patients can try during the study, even if they're encouraged not to. Psychological and physiological resistance and acclimation also occurs in these trials, especially if they are done over longer periods of time (1 week versus 12 weeks). Patient adherence and self-reporting is yet another clinical trial issue. The primary endpoint of the NKTR-118 trial is over 12 weeks (3 months). Nektar and its partner AstraZeneca are running just two Phase III trials to win approval of NKTR-118. The FDA requires two successful Phase III trials to grant approval.
Even if NKTR-118 works over 12 weeks, there are several other mu-opioid antagonists, including Relistor, CB-5945 and Entereg it will have to compete with. Using an 11% discount rate (quite generous given the operational hurdles), a 100% chance of success (no discount for failure), a $700 million peak sales estimate, a 21% no-cost royalty, no other costs whatsoever, the full value of filing and approval milestones, a patent expiry in 2026, 5% return on cash and full value for cash on hand now, I get a stock price very close to the current stock price ($8.22). Why would one go long a stock that is pricing in perfection? If anything at all happens to these projections, such as a competitor entrance, failure to achieve peak sales, failure to achieve clinical success, failure to persuade FDA of clinical significance, failure of IP, failure to reinvest funds properly, etc, the investment can be lost.
A bull might argue that $700 million is conservative for this product. That is impossible given the variety of other mu-opioid receptor antagonists there are. If approved, this drug would sell a lot less than $700 million, if the results are good at all, and if the FDA believes those results are worth approving. The FDA has been changing its mind quite a bit when it comes to constipation. Keep in mind no company has cracked the constipation market with a large product thus far. The Takeda/Sucampo product Amitiza is a relatively minor product with only ~$200 million in sales. Zelnorm was a $600 million product before it was withdrawn from the market and Lotronex sales are tiny. Entereg and Relistor sales are microscopic. Increasing spontaneous bowel movements is a reasonable endpoint for this disease but I question the medical significance of one more successful bowel movement than placebo in a one week period. With at least 3 look-a-likes, it is practically impossible for NKTR-118 to be worth $8 per share, and is probably worth $1-$2 per share in present value.
I don't value Nektar's next most highly valued product, a pegylated irinotecan called NKTR-102, very highly at all. In fact, I think the NPV of this project is negative. Cancer companies have abandoned developing new chemotherapies. Ask Bristol, Merck and Roche if they're interested in licensing NKTR-102. They'll stick with their PD1, MET and other exciting new targeted cancer drugs. Nektar is nevertheless running the Phase III "BEACON" study in almost one thousand breast cancer patients. This trial will take a long time to enroll and a long time to report results.
There is precious little evidence to handicap the results of this hail-mary Phase III. The company has some uncontrolled response rate data that seem encouraging, but with expectations moving so quickly with drugs like Perjeta receiving approval, it's hard to know what is good in breast cancer anymore, especially without randomized studies. I'm not a big believer in trying to predict OS data with uncontrolled response rates and single-arm survival.
Enzon has a very similar drug which the market is not giving it much value for. So I'm not sure we should do the same for NKTR. Of course, Nektar is spending an enormous amount of money on NKTR-102, which really drains from any value one might assign to NKTR-118. Nektar has routinely made missteps with NKTR-102. First, the company had us expecting a partnership for the product, which hasn't materialized. Next, the company suggested it could receive FDA approval in non-randomized ovarian cancer results, which is absurd. These false starts make me wonder if Nektar really knows what it is doing in cancer.
BAY855 is a pegylated hemophilia product being developed by Baxter with a royalty to Nektar. There is no clinical data I'm aware of for this compound and a ton of other companies are developing long-acting Factor 8 products. I suspect Biogen and others would have something to say if I valued this any more than nominally.
NKTR-061 is an inhaled antibiotic with minor sales potential being developed in collaboration with Bayer. It is unclear if this product is being pursued any longer after a very public set of issues. I don't value it as the sales potential of the product and it's current inactive state give me pause.
I don't value the rest of Nektar's preclinical pipeline which leaves us with their two Phase I pain projects. These aren't worth anything to be either. Trying to perfect pain drugs is a Sisyphean task. They are about as close to perfect as you're going to get in pharmaceuticals. Marginal improvements do not create value in the drug business (see tapentadol).
Nektar has a strange setup. The company has 423 employees, which seems about two- to three-times as many necessary for what it does. The stock price hasn't moved in 5 years and the CEO makes several million dollars per year, a lot of it in cash. Most importantly, the entire company had $113 million of negative cash flow in 2011, and they seem to be on a path to exceed even that in 2012. This greatly reduces any NPV of NKTR-118, to a point where even in a best-case-scenario that drug goes from being worth $8 to perhaps as little as $6. I don't like buying stocks where the most I can make is -$2 per share. The opposite holds true, I love shorting stocks where no matter how well the company's assets perform, the stock drops $2 due to the company's mismanagement of expenses and funding of low-impact projects and the implied 100% probability of success of the stock market.
As you might imagine, I am short Nektar stock and I suspect it will fall 80% when one of the NKTR-118 Phase III trials fails. If the trial works, the significant competition and small market size will result in the stock falling 50%-80% anyway.
It's time to recap my prior stock picks on SeekingAlpha.
Name | Entry | Price | Exit | Price | Days | Return | IRR | Comment |
Neoprobe | 6/1/11 | 5.25 | 8/5/11 | 2.00 | 65 | -62% | 1396% | |
Oncothyreon | 7/25/11 | 10.00 | 3/9/12 | 4.97 | 238 | -50% | 87% | |
Avanir | 5/31/11 | 4.62 | 11/25/11 | 2.00 | 178 | -57% | 151% | |
Mesoblast | 8/18/11 | 7.95 | Ongoing | 5.93 | 305 | -25% | 31% | Finally cracking. |
Biomarin | 6/8/11 | 27.12 | Ongoing | 37.04 | 376 | 37% | 35% | I think takeover rumors are true. |
Chelsea | 7/29/11 | 5.08 | Ongoing | 1.30 | 325 | -74% | -78% | Stay tuned. |
Zalicus | 7/6/11 | 2.60 | 11/9/11 | 1.16 | 126 | -55% | 258% | |
Human Genome | 8/28/11 | 12.63 | 3/19/12 | 7.89 | 204 | -38% | 77% | |
Star Scientific | 6/5/11 | 5.26 | Ongoing | 4.25 | 379 | -19% | 18% | Worthless. |
Ampio | 1/6/12 | 4.51 | Ongoing | 3.79 | 164 | -16% | 39% | Worthless. |
MannKind | 1/19/12 | 2.84 | 3/19/12 | 2.33 | 60 | -18% | 173% | |
Cytori | 3/19/12 | 3.13 | 4/10/12 | 2.10 | 22 | -33% | 11115% | |
Biotime | 4/10/12 | 4.39 | Ongoing | 4.27 | 69 | -3% | 15% | Worthless. |
Disclosure: I am short NKTR.
Author's note: I have removed the reference to the Litman et al. paper which I incorrectly misinterpreted. Thank you to a shareholder of NKTR for pointing this out. I misread this paper and apologize for any confusion that may have resulted. My thesis, is however, unchanged.
Additional disclosure: I may change my mind.


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I love you Hannah....BEAR!!!!
Trip Start
Apr 23, 2012
Trip End
Where I stayed
Hostel Tikaisy
First things first: shower! It was absolute bliss not having to be afraid that the water was frozen or that your hair would turn to icicles as soon as you stepped out. After that we went to an Internet cafe where I spoke to a guy I had met in Arequipa who told us about these Illegal raves they have in the desert: SOLD. We set off in search of the bar that had the information only to be extremely disappointed... the guy that organized them wasn�t in town for two weeks! Probably better for us: apparently the police always turned up and it wasn�t uncommon for them to arrest everyone, so it was probably better fr my mothers health too. So with that we bought four liters of cheap wine (but all wine�s good in Chile, Right?) to drink after Lorena made us an amazing omlette.
Solo myself and Katie on it we had our first encounter with a lovely Argentinian we thought was called Joe. After several failed attempts at teaching him and a group of Brazilians shit head, he taught us how to a Spanish card game where all the cards had different values to what they said ie. a five of clubs was not a five but some other random number. Having drank a good three litres of the vino tinto we were hopeless at the game and every time someone played a hand we would echo �Loceinto, no intiendo!� - I�m sorry, I don�t understand.
I came back from a toilet break to find Katie had went to bed, after apparently falling off the bench and hitting her head, the next few hours consisted of me constantly forgetting this and asking in slurred Spanish �Where�s my friend?� The next morning I woke up to find Katie gone fetal in the bed opposite me asking what to do about that.
Turns out that when she got in the room the night before she had managed to projectile vomit pure Chilean red all down the wall and curtains... I suggested some eggs and that cheered her right up. In the end we cooked an amazing breakfast: we had eggs, obviously, yogurt, cereal, toast, coffee and even orange juice! Perked us right up.
Later that day I went to the moon valley, so called because of it�s likeness to the surface of the moon. The landscape was beautiful. First stop was a lookout point from the north of the valley: I could definitely imagine the surface of the moon looking like that, jagged mountains in a sort of rippling effect, dusty and dry. Then we saw the death valley where we could do an optional hike to the top and can you believe it? Given the choice, I did it! Tinto, let�s behavin ye...
We then went to the national park where the landscape was even more alien, I can�t even describe it. Apparently it�s so similar to the moon that NASA use it as one of the main bases for testing. We stopped to see various landmarks and to top off the day we climbed the biggest sand dune there to watch the sun set over the valley, no pictures I took doing it any justice: the colours on the Andes in the background seemed to change every time you looked.
When I got back to the hostel I met Lorena, �Joe�and Katie, only Lorena was calling him
�Matte�... I asked Katie about this and she explained, rather embarrassed, that his name actually was Matte: when we asked him the night before what his name was he answered `jo?�, in Spanish �o�means �me�, but Argentian�s pronounce y�s as j�s. So when he said �jo� he was actually asking �me?�, we must�ve just been too drunk to hear when he said Matte. That night Matte cooked us all a delicious dinner, did I mention he was a chef in Argentina? While he worked his magic in the kitchen we went to get some supplies for mine and Katies last night together before she went to Santiago to fly home. Couple litres of wine, a bottle of Pisco and fourty fags: ingredients for a good time. We had an amazing vegetable stir fry with rice.. I know, I thought I�d never eat it again either but this wasn�t just any rice, this rice was so tasty I could have lived of it for the rest of my life... I wonder what the hell he did to it.
Bellies full after we had had several helpings, we sat around the fire while the Brazilian guys played guitar and talked. Then, about half one we were told to go to bed! feeling like children we went sheepishly to our room and decided a sleepover was in order, then the 96% miners alcohol got pulled out... Having no mixer left we sucked it up and drank it straight, now mum... calm down: i�m fine, I have never had such a fright as I did when that stuff hit the back of my throat, however I sucked it up and we managed to finish the bottle between us before cuddling up and watching a movie on my ipod.
Hungover does not cover it... Katie woke me up at six with `I really want some eggs.` Unable to move I let out a slight groan and five minutes later she was back with two fried egg sandwiches: one each. Struggling to keep it down we passed out to wake up a few hours later with the sole purpose of making more eggs before Katie got her bus. We had to run to the bus after our �last supper�. It was really sad saying goodbye to Katie: we had met by chance in Arequipa and got on so well we wended up travel ling together for half of our trips; two and a half months! When I got back to the hostel I immediately got into bed, feeling like the eggs were going to make an unwelcomed reappearance, to find a letter from Katie. It was lovely, illustrated with pictures of Babs and other times we had spent together... and on came the water works!
The next day I woke up and with a towel wrapped around me went for a shower only to have Matte shout across the courtyard at me `Moi Blanco!� - very white... apparently I do not have my mothers genes. I spent that day trying to have a conversation with Matte, cooking crepes, most of my input being �Lociento, No inteindo`... Argentian Spanish was very different to what I�d learnt in Peru!

subset: commoncrawl


text:
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540W power supply |
Post Reply |
Author | |
Platinum (NL) USERID: 928806 Newbie Joined: 28/May/2011 Online Status: Offline Posts: 14 |
Quote Reply
Topic: 540W power supply Posted: 24/Mar/2012 at 4:16am |
a few days ago I received my power supply. Today out of the box and in good spirits connected. Doing absolutely nothing, completely dead. I am very dissatisfied. I got it with the Turnigy X200 charger bought but can not use it now. Could it be the fuse? How can I change the fuse and how about the warranty?
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Feb. 12, 2014
Auburn vs. Kentucky Feb. 12, 2014 | Auburn, Ala.
Head Coach Tony Barbee On the team's shooting performance... Our guys played hard. I'm proud of how hard our guys fought and how tough they were, but at the end of the day give credit to Kentucky. They made winning plays when the game mattered. With 10 minutes to go in the game we had a three point lead and from that point forward they made the majority of the winning plays. That's what this game comes down to. We fought hard too, I thought we played as hard as them, but at the end of the day they made more winning plays. That doesn't mean they made more shots, they made more winning plays. Offensive rebounds, more loose balls, defensive rebounds and some big shots on top of it."
On Matthew Atewe... "Atewe played well, it's just a glimpse of what he can be. He has a chance to be a warrior out there, a beast on the backboard, blocking shots, we just have to help him keep improving.
On K.T. Harrell's shooting... "I give them credit. They're a good defensive team and hard with their length, but guess what, you still have to make plays if you're going to be one of those high level guys."
On Kentucky's defense... "They're a good defensive team. They can switch with their fours and fives, their ones and twos can contain you and make it hard. They're hard to score on that way."
On K.T. Harrell's offensive struggle... "No it's not disappointing. I know he's hurting because of the type of competitor he is, but there's no secret, we need Chis Denson and K.T. Harrell to play big for us at the same time. We've got some other guys that aren't as good as those two offensively so he's expected to produce. There's no one hurting more than him."
On the other players... They need to make winning plays. Offensive rebounds, defensive rebounds, getting lose balls. We had our opportunities, but we didn't take advantage today."
On rebounding... "You've got to go get them, you've got to go get rebounds. That's what it's about."
Senior guard Chris Denson On coming up short... "I'm very disappointed. Like all the games we've lost, we lost in the trenches, or rebounding. We let up too many offensive rebounds. We didn't make plays down the stretch. We were up by 3 and we were conservative trying to hold the lead and we can't do that with a good team like Kentucky."
On playing aggressively after pulling ahead... "We were in the passing lanes because we saw that they were being lazy with the ball, but I guess Coach Calipari got to them because they were very safe with the ball. We couldn't get to the passing lane like before, but the game was lost by rebounding."
On him and KT Harrell not both playing their best... "It's hard because Coach Barbee always tells everyone to contribute to the team. Kentucky had a lot of players in double figures and for Auburn it was just me. I have the ultimate trust in KT, the whole team does. We thought we were going to get it going but we have those type of days. It's tough to beat a team with one person in double figures."
On the late lead changes... "We've been there. We have been down and in that situation. Especially against South Carolina, we made that run and came back. Our heads were still high, but we didn't make the right plays down the stretch. We missed shots, gave up offensive rebounds, and that killed us."
On being in a lull in the middle of the game.. "It's very frustrating. We have the playmakers and we have people that can do it. I don't know if we came out too timid, but we should have done what Coach Barbee said and hit the gas pedal when we were in the lead."
On missing shots... "We definitely hit a wall with the missed shots. KT couldn't get it going tonight and I would call it a snowball effect. The offensive rebounds destroyed us."
On effect of hitting lulls in games... "We almost let a couple go against Georgia and South Carolina, but you can't let a Kentucky team have a chance. Coach Barbee said we gave them hope because when we took the lead, they were timid, but they made a plan and we gave them hope."
Kentucky Head Coach John Calipari On tonight's game... "We shot 30 percent and won the game. That is old school. We just didn't have a whole group of guys playing. James (Young) gave us nothing. We broke down. We didn't rebound. We were soft. Dakari (Johnson) was outstanding. In the second half, Julius (Randle) played the way he needs to play. The picture he has of himself is not the picture he needs to play with. He needs to see that second half, the block out of nowhere, the offensive rebound and that tip-in. We didn't make foul shots. Guys were only hitting one out of two from the line."
On Julius Randle... "He needs to sprint the court. He needs to be the hardest worker on the court and fight like crazy for offensive and defensive rebounds and see what you get on offense. Don't worry about the offense. Just do all that other stuff. He is not being evaluated like other guys are. Guys that are 6'4 are going to be evaluated differently. He is doing fine. He had a great second half. Aaron (Harrison) made a great basket. Andrew (Harrison) made a great basket. We got the rebounds that we needed to and we got out with a road win. We shot 30 percent. I am happy."
On if tonight reinforced defense to the team... "I don't know. We won the game. I will probably watch tape on the plane and be yelling in the front. We had guys we took out because they weren't going through the motions of playing. I am going to play guys that are going to fight and battle."
On what he said to the team after the timeout up three... "What I said to all of the guys is that I am going to play the guys that are going to fight. If you are not into this, you are not playing. Let's go to Julius. I am telling the guards we have guys like James Young who are driving. In the first half, Andrew and Aaron were shooting all threes. We are learning. We are still in our motions on offense. I told them after the game, at some point, if you want to be special, that has got to change. Our motions has to be about team defense. That's it. Nothing else."
On the second half... "They had the will to win, which I liked. Again, it is time. Enough. I can't say it anymore. I have said it 1000 times. Why am I saying it publically? I want them to read it."
On Auburn's performance tonight... "Tony has done a great job. They didn't make shots that they have been making, or we lose the game. They had Florida. It was a 1-point game late. Tony is doing everything to keep these guys on a high level. The schedule they played early, all that stuff they just played, they are going to get the other side of it now. I think what you will see is them win. By the end, I think they will be fine."
On holding KT Harrell to seven points... "We had some size on him. If you don't have size on him, he is really good. But, you had (Chris) Denson get to his left hand. I told the guys that he is lefty. He will split you left, fake right. He is coming left and he just did it anyway. He had nine at halftime."
Julius Randle On winning a ugly game... "Yeah, it was an ugly game. We stepped up, the guys showed leadership and we won."
On what made it an ugly game... "We couldn't make a shot. We weren't doing the little things and not doing what coach was asking us to do. There came a point in the game that we had to let it go and just play."
On not getting good shots... "We were getting good shots. We just weren't making them."
On how missing shots affects everything else the team does... "I don't let it affect me. I just think about trying to score the ball and stuff like that. I just make sure I'm doing the little things."
Andrew Harrison On if Coach Calipari is happy about with an ugly win like this... "Yeah, I think he's pretty happy about this win. Some of our scorers didn't play as good as they usually do, but they still played hard and that's what we needed."
On playing good defense in the second half? "There comes a point in the game that you have no choice to play good defense or you'll lose the game. It comes from mental toughness and from inside of you."
On what coach Calipari tells you in a bad offensive game like that... "When it's going like that he just really talks about defense and taking good shots. Not taking as many 3-pointers and stuff like that. He told us at halftime to not shoot as many threes and I shot the first three. I'm so happy I made it, but it was a good grind out win."
On if the team needed a game that depended on defense to win the game... "Yeah, definitely I think so. It shows we are a tough team and we can't score. It shows that we can stop people as well. We're just a young team and getting better every day."


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http://iowa.rivals.com/showmsg.asp?f...id=940&style=2 Heres an interesting link to HR. Good thing most Hawg fans didnt go to Iowa, this would reflect bad on their math dept.
Wow - stay in school kids.
Wow is right. Just....wow.
It's Like Watching Chimpanzee's at the Zoo
"Day after day, situation after situation you do things the right way. If you do things the right way, in life, you are going to be successful. I'm not just your football coach; I'm not just here to win games. I could not be prouder of who we are and who we are becoming, together. You do things right in the classroom, off and on the field; that's whats's makes us Cyclones and that's what our culture's all about." -Paul Rhoads
I don't see the need to degrade and beat down on Chimpanzees that hard
OK, this is why I'm an English major, and not a Math major but... what's so humorous about this?
"Seven minutes to glory."
Good grief, talk about a brain drain. That quote from whatever movie that the mad scientology goofball Tom Cruise makes the statement that "nobody in this room is even remotely smarter for having heard this conversation" definitely applies here. I don't think 800mg of Ibuprofen is going to touch the headache I got from that thread. Don't they have better things to do like coming up with lame excuses why they should be in the NCAA tournament or see if they can all get together to get a group rated on a travel plan to next years BCS championship since they got a new QB who is all that and a bag of chips??????
OMG this is hilarious. they never figure it out (at least on the first page). leave it to those egotistical idiots to not figure out that there are TWO teams in each game.
That is, without a doubt, one of the funniest threads that I have ever read. It has to become a classic.
It's the thread that won't die. On a serious note, you'll get brain rot if you keep going to that site.
Wow, and I thought Hawk fans were just arrogant. I'm still wondering what the "11 x 9= 99" had to do with anything. I couldn't go on to the second page. The first page was painful enough. Hopefully someone remembered that 11 divided by 2 is 5 1/2, which means that EVERY WEEK SOME TEAM IS EITHER OFF, OR PLAYING A NON-CONFERENCE GAME. WHICH IS THE WAY IT'S HAPPENING NOW. Poor Dr. Van Allen must be spinning in his grave.
I bleed Cardinal & Gold
To all chimpanzee's in the world I am sorry for comparing you to Hawkeye fans
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COLUMBIA — A coalition of community groups is claiming that by not disclosing police reports for incidents in which officers used Tasers, the Columbia Police Department is not following Missouri's open records law.
In a statement released Friday, the Coalition to Control Tasers, which is made up of eight local progressive groups, said it has tried to obtain arrest records from Taser incidents dating back to May 1, and that the department has used provisions of the Missouri Sunshine Law to keep the records closed.
Ed Berg, a member of the Coalition to Control Tasers, said in the release that the department has also refused to provide documents regarding the incidents at free or reduced charges, and have "reclassified documents," thus preventing their disclosure.
"The failure of the police to follow the spirit and intent of the Sunshine Law in making the information available to the public causes residents to be suspicious of Taser use by the officers," Berg said.
Mary Hussmann, another member of the Coalition to Control Tasers, said the latest high-profile Taser incident, in which Carl Alan Giles was shocked with a Taser on Aug. 1 in an alley behind Cafe Berlin, has raised questions about the department's adherence to new Taser guidelines. Shortly after Chief Ken Burton started in April, the department agreed to adopt a set of 52 guidelines for Taser use outlined in a national report by the Police Executive Research Forum.
"What good does it do to have Taser PERF standards if officers aren't following them?" Hussmann said in the release.
Deputy Chief Tom Dresner said in an e-mail message that there have been 14 incidents involving a Taser since May 1, and that only four involved the actual deployment of the device. Ten of the incidents involved either a display of the device's laser sight, or a "spark demonstration," in which an officer shows the device's ability to conduct an electrical charge.
Dresner said the coalition's statement "blindsided" the department because the group had not previously voiced the complaints to the department. He said Burton has met with the coalition twice since taking office.
"It's sad to think that after we came to agreement about the PERF standards that our mutual spirit of cooperation seems so short-lived," Dresner said in the message.
He also noted that the Police Department receives an average of 50 Sunshine requests a day, and will not give special treatment to the coalition.
The coalition's statement is the latest step in a yearlong struggle with the Police Department over Taser records. It began in August 2008, when Berg filed a request for records related to the department's use of Tasers. In November 2008, the department released 49 records from 69 Taser incidents from that point in time dating back to 2006. The 20 records that weren't released were closed because they were incidents involving juveniles or they were part of an ongoing investigation.
Columbia Police Sgt. Krista Shouse-Jones, who is the interim custodian of records for the department, said the incidents for which the group has requested records since May are still active investigations, and said those records could be kept closed even while a case is in the court's appeals process.


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Part of the "AIGA Voices" webcast series, features thoughtful and influential designers—including AIGA board members—speaking about a wide range of topics.
"Graphic Design: Now in Production" is a traveling exhibition on contemporary graphic design organized by Andrew Blauvelt of the Walker Art Center in Minneapolis, and Ellen Lupton of the Cooper-Hewitt National Design Museum in New York. The first major museum show on graphic design since 1996, this exhibition examines the state of the field with an emphasis on how designers are seizing control over the means of production to realize new creative projects, as graphic design expands from a specialized profession into a more popular and widely deployed tool.
With the rise of user-generated content and new creative software, along with innovations in publishing and distribution systems, people outside the design field are mobilizing the techniques and processes of design to create and publish visual media. At the same time, designers are becoming producers: authors, publishers, instigators and entrepreneurs, employing their creative skills as makers of content and shapers of experiences.
Featuring work produced since 2000 in the most vital sectors of communication design, "Graphic Design: Now in Production" explores design-driven magazines, newspapers, books and posters, as well as branding programs for corporations, subcultures and nations. It also showcases a series of developments over the past decade, such as the entrepreneurial nature of designer-produced goods, the renaissance in digital typeface design, the storytelling potential of titling sequences for film and television, and the transformation of raw data into compelling information narratives.
This talk, illustrated with numerous examples, provided an overview of the various themes and topics that arise from the exhibition.
This session was recorded on April 17, 2013. Watch this webcast.
Andrew Blauvelt is chief of communications and audience engagement and curator of architecture and design at the Walker Art Center in Minneapolis, and an AIGA national board memberFrom 1998 to 2010, Andrew served as design director, providing creative leadership to the Walker's progressive visual identity and publishing program. As a curator, he has organized numerous traveling exhibitions on a variety of topics including contemporary prefabricated residential architecture, the changing landscape of the contemporary American suburb and the use of ordinary materials and everyday rituals in the creation of extraordinary products. As a graphic designer, his work has received nearly 100 awards and has been extensively published and widely exhibited. He is a national board member of AIGA and an elected member of the Alliance Graphique Internationale (AGI).
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The "AIGA Voices" series offers public webcasts featuring thoughtful, influential designers—including AIGA board members—speaking on a wide range of topics relevant to the design industry.
Section: Events and Competitions - Tags: Event
AIGA's chapters allow our members to form powerful social and professional bonds through conferences, competitions, lectures and community events.
Section: About AIGA - Tags: AIGA chapters
Learn more about AIGA's national conferences and events, and access videos from select conferences and awards events.
Section: Events and Competitions - Tags: Conference , Event
Joao Souza
"The Massage Is the Medium," by Yin Aiwen
April 20, 2015
LeRoy Winbush
UX Architect at LaneTerralever
Art Director – Resound Creative
Together we can do amazing things.
April 15, 2015
How to Prepare A Design Portfolio for Ink & Pixels Portfolio Review
March 29, 2015
Sean Miller
Graphic Design InternPrinceton Architectural Press
New York, New YorkApril 14 2015
Workspring Identity


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Asymptotics for an adaptive trimmed likelihood location estimator
Bednarski, T. and Clarke, B.R. (2002) Asymptotics for an adaptive trimmed likelihood location estimator. Statistics, 36 (1). pp. 1-8.
*Subscription may be required
An asymptotic normality result is given for an adaptive trimmed likelihood estimator of location, which parallels the asymptotic normality result for the adaptive trimmed mean. The new result comes out of studying the adaptive trimmed likelihood estimator modelled parametrically by a normal family but then examining the behavior when the underlying distribution is in fact some F different from normal. The asymptotic variance of the adaptive estimator is equal to the asymptotic variance of the trimmed likelihood estimator at the optimal trimming proportion for the distribution F, subject to that trimming proportion being positive and F being suitably smooth.
Publication Type: | Journal Article |
Murdoch Affiliation: | School of Chemical and Mathematical Science |
Publisher: | © Taylor & Francis |
Copyright: | 2002 Taylor & Francis Ltd |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/4787 |
Item Control Page |


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I had actually done this one before the version with the boys. People were clamoring for a version with boys, so I took that one on.
A very talented artist; your work has a very strong sense of character; very clear and precisely delineated figures/forms; too, the light/shade tonal control is excellent; as well as, I have to say I admire the overall composition/design; there is loads of imagination being involved, as well. To me, this all speaks of somebody who is a 'very highly experienced' artist. ;-)
My wife and I have about 2,000 books on our shelves. Our two kids are in their early twenties now and I rarely see them look at the shelves. That is the downside to modern technology in my opinion. You're a fantastic artist by the way, but that is stating the obvious :)
I tell you, I have had to learn to really ween myself from the telly. I was one of those TV junkies until I married my reader of a wife. I completely see that perspective now.


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Dylan Ryan
7,760pages on
this wiki
this wiki
This needs a stretch. |
Dylan Ryan | |
Vital Statistics | |
Gender | Male |
Hair color | Brown |
Eye color | Black |
Other Statistics | |
Occupation | Student |
Affiliation | Brenda |
Production Details | |
First appearance | SDMI: Revenge of the Man Crab |
Played by | Mitch Watson |
Dylan Ryan[1] is a teenager from Crystal Cove.
[show]Physical appearance
Insert details here.
Insert details here.
Scooby-Doo! Mystery Incorporated
Season one
He was setting up for a volleyball competition on the beach with the help of his girlfriend Brenda when she was dragged under the sand and kidnapped by the Man-Crab.
He and Brenda went to Creepy Spooky Terror Land after their release from the hospital and got kidnapped by the Manticore.
Season two
He and Brenda were attacked by Hebediah Grim. Brenda apparently dumped him for Gary after he "saved" her from the monster. However, after it was discovered that this was all a part of his and Ethan's scheme, it unknown if she took him back or not.
- Scooby-Doo! Mystery Incorporated
- 104. Revenge of the Man Crab
- 121. Menace of the Manticore
- 209. Grim Judgement
- Dylan is based on the Beverly Hills, 90210 character, Dylan McKay (played by Luke Perry).
- He was the victim in the teaser of all three episodes he appeared in.
In other languages
Actor | Language | Notes |
Espen Sandvik | Norwegian |
- ↑ His last name is revealed in a closeup of the school yearbook in Grim Judgement


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Teaching Abroad - Specific Organizations International Schools Services O Hayo Sensei (Teaching Jobs in Japan) Overseas Placement Service for Educators - University of Northern Iowa Teach Abroad - Council on International Educational Exchange Teaching Assistant Program in France WorldTeach Teaching Abroad Advice eslbase esljobs.com - Tefl Certificate Programs: A Beginners Overview Overseas Digest
Teaching Abroad Advice eslbase esljobs.com - Tefl Certificate Programs: A Beginners Overview Overseas Digest


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CoSN Launches Mobile Initiative, Online Community
The Consortium for School Networking has launched Access4Ed.net, an online community of practice designed for sharing strategies and ideas to provide access to online communities in K-12 schools. The organization has also launched a new mobile learning initiative aimed at overcoming the barriers to mobile device adoption in K-12 schools.
MoreArizona Schools Offset Energy Use with Solar Arrays
Copper Ridge School in Scottsdale, AZ and Cholla Elementary in Casa Grande have completed the installation of solar electric systems with a combined power output of 764 kilowatts.
MoreMicrosoft Steps Up Accessibility
Microsoft is giving a boost to accessibility in its Office 2010 suite and launching new training courses and resources dedicated to helping developers produce more accessible sites and software.


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A below grade upgrade with 1,600 square feet of "wow"
-Find top-rated Service Providers
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Margarita H Deliz
Zephyrhills, FL
Basic information on Margarita H Deliz, Zephyrhills FL. Find Margarita H Deliz's age, gender, possible aliases, relationship status and professional status.
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How to Calculate Price Per Square Foot for House Painting
Two Methods:exterior PaintingSpray Painting
Nothing gives a house a fresh look like a new coat of paint. Whether you're doing the painting yourself or hiring someone to do it for you, knowing how to calculate price per square foot for house painting is a helpful way to estimate costs and compare quotes. Calculating per square foot can also help do-it-yourself painters buy the right amount of paint for the job.
1Factor in the price of paint and materials when you calculate for house painting.
- Include materials for preparing, mixing, applying and cleaning up paint in house painting costs.
- Professional house painting costs also include labor.
Ad -
2Estimate the amount of paint, with a gallon of primer, or base paint, covering 330 square feet and a gallon of other paint providing coverage up to 350 square feet.
- The composition of base paint is different, which is why it covers fewer square feet per gallon.
- Paint costs can range from $15 to $60 per gallon. Designer and specialty paint can increase house painting costs even more.
3Figure the cost per square foot of a professional's flat fee by dividing the cost by the square footage.
- For example, an $800 estimate for 1,500 square feet would be 800 divided by 1,500 which is equal to a 53.3 cent cost per square foot.
4Determine exterior square feet by multiplying the height times the width of each exterior wall.
5Add the square footage of each of the exterior walls together to find the sum total.Ad
Method 1 of 2: exterior Painting
1Calculate for house painting by multiplying the length by width of the room or rooms that you want to paint.
- Add the individual sums together.
2Measure the height and width of each door and each window in a room to be painted.
- Multiply height by width to find the square footage of each door and window.
- Combine the totals for each door and window to calculate for house painting.
- Subtract the door/window total from the room square footage for house painting costs.
- The average window is 16 square feet and the average door is 21 square feet. When a window or door is slightly smaller, multiply the total by .80. If larger, multiply by 1.5.
3Decide if you will also be painting the ceiling.
- Find square footage by multiplying two adjacent sides.
- Ceilings tend to take up to 85% more paint, particularly acoustical and popcorn ceilings.
Method 2 of 2: Spray Painting
1Reduce the cost per square foot by spray painting large paint jobs.
- Small jobs aren't economical when you factor in the cost of a sprayer, which can cost hundreds of dollars.
2Consider the transfer efficiency of spray painting equipment when you calculate for house painting with spraying.
- Spray painting tends to only get a portion of the total paint on the intended surface. The remainder ends up in the sprayer's exhaust filters or on the floor.
- Transfer efficiency is the total paint sprayed divided by the paint that reaches the surface.
3Multiply the cost per foot by the transfer efficiency percentage to reach a more accurate calculation per square foot.Ad
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- Indoor textured walls require more paint than smooth walls.
- Most experts suggest to use "brand name paints" in order to allow for single-coat coverage.
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Español: calcular el precio por metro cuadrado para pintar una casa, Português: Calcular o Preço por Metro Quadrado para Pintar uma Casa, Italiano: Calcolare al Metro Quadro il Prezzo per Imbiancare una Casa, Русский: рассчитать стоимость покраски квадратного метра дома, Deutsch: Den Quadratmeterpreis für einen Hausanstrich errechnen
Thanks to all authors for creating a page that has been read 144,594 times.


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Rock Ensemble
Rehearsal Schedule Wed | 3-5:50 PM MacAlister Hall, 2036
Rock Ensemble is an ensemble where students have the opportunity to gain experience working as a group rehearsing, arranging, organizing, recording, and ultimately performing songs in the rock/pop/contemporary genres. The group is recorded several times each term by the Recording II class, and performs a concert at the end of each term. Rock Ensemble has become one of the premier performing ensembles at Drexel.
Email: email@example.com Phone: 215-895-6214


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Wasn't there a study that traced mitocondrial DNA back to a woman living in Africa however many thousands of years ago??
I'll back anything that will help keep 'Creation Science' out of Schools.
Exactly how did a weak hairless ape with poor senses, small litters, and young that are not able to fend for themselves for the lifetime of most predators come to be the dominant species and develop concepts that have nothing to do with survival? Did we catch breaks at exactly the right time every time? Why didn't other species with similar advantageous skill sets emerge? Whatever your personally theory is, you have to take a leap of faith because the calculators say we should have been very much extinct during the hunter-gather days.
F/A-18E/F Super Hornet: The Honda Accord of fighters.
Because long ago man was a more violent animal that one can imagine today. Imagine a world without law and order, only the strongest survive, take what you can get, get what you can take. In todays orderly techno-oriented, politically correct world, people can't imagine the time that if I wanted something you had and you resisted me taking it, it was a simple matter of who could kill who. Winner take all. No dialing 911, simple kill or be killed.
What spawned so called civilization, was when a bunch of those ape-men decided that if they work together and gang up on the loners or the smaller groups, they extended thier life expectancy and all they had to do was share the spoils.
Much like today, but on a larger scale and much more complicated to make it seem like it is nothing as barbaric as hundreds of thousands of years ago.
We've come a long way, or have we?
I never saw this response back in July, so sorry.
My tangential response to your question above is to ask you if you're aware that you've really dropped all pretense at scientific exploration here and gone right to plain old Creationism.
Science doesn't provide solid answers to the question "why?" And your challenge above is poorly-constructed anyway. There is no indication that early hominids were either weak or deficient in senses. In fact our good vision has long been thought to be a primary, if not the primary adaptive trait that pushed the devlopment of our main adaptive Royal Flush - the brain.
So did we catch breaks as a species? Almost certainly. But we had the traits to allow us to take advantage of those breaks, and so voila!
Think of us as lotto winners. Many species participated. We won. God didn't have a plan for us just like he didn't plan for so-and-so to win the Power Ball last month. All will participate and only one will win. Remember, dinosaurs won continuously for 150 million years. We only had less than 4 million years. We could easily be wiped out when something weird happens. Then another species would have "won" after we depart.
"Only Nixon can go to China." -- Old Vulcan proverb.
Christ on a bike!
Look at the size of the cosmos - There must be billions of planets with life like ours on them.
We will never meet each other. The cosmos is just too big.
Billions of planet earths (who knows what those inhabitants look like?)
We will never meet or know about them - The whole thing is just too BIG.
Have a nice life.
So, your pure hatred of religion has you both completely walled off to any explanation other than a 50 trillion to 1 long shot.
F/A-18E/F Super Hornet: The Honda Accord of fighters.
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text: Splat can't wait to try out his brand-new roller skates! But when it starts to rain, Splat's sure that his day will be ruined. Is there anything fun to do inside? Beginning readers will love this easy-to-read addition to the Splat library! Type: Paperback () Category: > Home Schooling ISBN / UPC: 9780062090171/0062090178 Publish Date: 11/1/2012 Item No: 313701 Vendor: Harper Collins Publishers |


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text: Country Satellite is your "LOCAL" Satellite Retailer. We are a Premium Retailer" for "DISH Network" and "Directv". Our goal is to make you happy. We will find out what you need and get you the best programming at the best price. We have everything in our showroom so you can see exactly what you are getting. We can come to your home and check things out so you know it will be the way you want it. Being "LOCAL" also means we are here for you if problems or questions arise.


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Chris was contacted by a lady who had purchased a six year old thoroughbred called George who was fairly green and asked to go along and evaluate him. Within minutes of meeting him Chris recognised that George was extremely tense and distrustful of people.
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Gout, a painful form of arthritis, occurs when high levels of uric acid in the blood cause crystals to form and accumulate around a joint.
Uric acid is produced when the body breaks down a chemical called purine. Purine occurs naturally in your body, but it's also found in certain foods. Uric acid is eliminated from the body in urine.
A gout diet may help decrease uric acid levels in the blood. While a gout diet is not a cure, it may lower the risk of recurring painful gout attacks and slow the progression of joint damage. Medication also is needed to manage pain and to lower levels of uric acid.
Gout has been associated for centuries with overindulgence in meats, seafood and alcohol. The condition was, in fact, considered a disease of the wealthiest people — those who could afford such eating habits. And long before the cause of gout was understood, doctors had observed some benefit of a restricted diet on gout management.
Once the cause was understood, a gout diet focused for many years on eliminating all foods that had moderate to high amounts of purine. The list of restricted foods included the following:
Understandably, it would be difficult to stick to a diet that eliminates so many foods. Also, the list includes foods — especially vegetables and legumes — that would otherwise be considered healthy.
More recent research on gout and specific foods has created a much clearer picture of the role of diet in disease management. Some foods should be avoided, but not all foods with purines should be eliminated. And some things should be included in your diet to control uric acid levels.
The purpose of a gout diet today is to address all factors related to disease risk and management. Above all, the goals are a healthy weight and healthy eating — a message that applies to lowering the risk of many diseases.
The general principles of a gout diet are essentially the same as recommendations for a balanced, healthy diet:
Recommendations for specific foods or supplements include the following:
Here's a look at what you might eat during a typical day on a gout diet:
Following a gout diet can help limit uric acid production and increase its elimination. Although the diet isn't likely to lower the uric acid concentration in your blood enough to treat your gout without medication, it may help decrease the number of attacks and limit their severity.
Following the gout diet, along with limiting your calories and getting regular exercise, can also improve your overall health by helping you achieve and maintain a healthy weight.
The gout diet is primarily the same as standard recommendations for healthy diets that emphasize vegetables, fruits, whole grains, low-fat dairy and moderate lean meat consumption. Therefore, there is generally no risk associated with the diet.
Original article: http://www.mayoclinic.org/healthy-living/nutrition-and-healthy-eating/in-depth/gout-diet/art-20048524


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The Perfect Blender For Busy Runners
April 16 2015
Upgrade your old smoothie habits with this perfect blend of speed and smooth results.
Looking for an easy (an healthy!) weeknight dinner? Our roasted salmon will hit the spot!
Recipe courtesy of Jesse Schenker
Serves 4
1 lb. wild salmon, filleted into 4 portions
1 1/2 cups orzo pasta
2 cups freshly shucked peas
1 bunch green asparagus, cut into ½ in. pieces
1 lemon, juiced
2 Tbsp. extra virgin olive oil
2 Tbsp. basil, chopped
Kosher salt to taste
1/2 cup Parmigiano Reggiano, grated
Preheat oven to 400 degrees.
Bring a large pot of water to a boil. Cook orzo in water for 8 to 10 minutes. Turn off the burner, strain pasta and put orzo back into pot, set aside.
Place salmon on baking pan. Drizzle with 1 Tbsp. olive oil and sprinkle with salt. Roast in oven for 8 to 10 minutes.
While salmon is cooking, place orzo pot on low heat, and stir in asparagus and peas. Cook for 3 to 4 minutes, stirring constantly. Remove pot from the heat and stir in the remaining olive oil, basil, Parmigiano and lemon juice.
Spread finished orzo on large platter with salmon on top. Serve immediately.
Nutritional info per serving: 621 calories, 46g protein, 21g fat (4g saturated), 61g carbohydrates, 8g fiber, 129mg sodium


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Can I use a Logitech THX-Certified 2.1 Speaker System as a theatre system at home?
We've heard your feedback and are continuing to build a better Slickdeals. Click here to check out the updated site.
Although, the speakers are THX certified, they are meant to be connected to a PC or video game console directly for sound. Having said that.You could connect these speakers to the TV, and it may sound okay. It will probably even be louder than your TV speakers, but the quality will not be as good because it uses an analog connection.
I would recommend purchasing a 5.1 channel home theatre system or just sticking with the TV speakers, because the sound quality will be better. Hope that helps. |
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Welcome! This is the National Archives and Records Administration's (NARA) blog to discuss all things RACO. This year's Washington, DC area RACO is going to be held on May 28, 2009 at the Ronald Reagan Building. Our theme for this year is "Collaborating Across Boundaries: Government Records and Social Media" and this blog is one […]
Posted by on May 7, 2009, under General, RACO 2009. Comments: 1
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Featured on HGTV's "Design Star" Season 6, Episode 4. Blend old and new in this very spacious refuge that transports you back in time. A queen and a full size bed, art deco bureau, floral touches, and bath with window letting in fragrant breezes hint of the past, while modern comforts surround you. Relax in the recliner with your favorite book and drift into a wonderful night's rest. Click thumbnails below to view larger images.
Click on the links below to view our other rooms: The Turret | Morning Glory | Sunrise | Moonbeam | Americana | Garden Delight | The Claddagh | The Seraphim
The Tower | Victoria Rose | The Canopy | The Corner | The Lighthouse | The Nostalgia | Serenity | Secret Garden
If you have any questions, or would like more information, please call us at 732.449.2010, email us, or use our online request form.


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Girl, born February 2004
Cerebral Palsy
Shirley is a sweet girl who has been diagnosed with Cerebral Palsy and high muscle tension in her legs. She has had surgery to help with the tension in her tendons. Shirley loves to play dress up with her dolls. She is currently attending a primary school and is learning a lot! Shirley has been living in a foster family since 2006 so that she could get more individualized attention. She go to therapies every day to make her body stronger. Shirley is able to take care of all her personal needs and is very independent. She has been taught about adoption and would like to be adopted!


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Today, on the Lauren's Hope blog, we welcome guest blogger, Jacquie Paul Wojcik, whose blog, Typical Type 1, chronicles her (busy, healthy, active, funny, normal) life with Type 1 Diabetes. We hope you'll check her out!
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Tags: diabetes, Typical Type 1, T1D, guest blog, Guest Blogger, diabetes medical ID bracelets, diabetes story of hope


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Loza, A. and Mihaylova, L. and Canagarajah, N. and Bull, D. (2006) Structural Similarity-Based Object Tracking in Video Sequence. In: Information Fusion, 2006 9th International Conference on. . ISBN 1-4244-0953-5
| PDF (SSIM_Fusion2006.pdf) Download (760Kb) | Preview |
This paper addresses the problem of object tracking in video sequences. The use of a structural similarity measure for tracking is proposed. The measure reflects the distance between two images by comparing their structural and spatial characteristics and has shown to be robust to illumination and contrast changes. As a result it guarantees robustness of the tracking process under changes in the environment. The previously used Bhattacharyya distance is not robust to such changes. Additionally, when a tracker is run with the Bhattacharyya distance, histograms should be calculated in order to find the likelihood function of the measurements. With the new function there is no need to calculate histograms. A particle filter (PF) is implemented where this measure is used for computing the distance between the reference and current frame. The algorithm performance has been tested and evaluated over real-world video sequences, and has been shown to outperform methods based on colour and edge histograms.
Item Type: | Contribution in Book/Report/Proceedings |
Uncontrolled Keywords: | Similarity measure ; object tracking ; video sequences ; particle filtering ; DCS-publications-id ; inproc-452 ; DCS-publications-credits ; dsp ; DCS-publications-personnel-id ; 121 |
Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science |
Departments: | Faculty of Science and Technology > School of Computing & Communications |
ID Code: | 4375 |
Deposited By: | Dr L Mihaylov |
Deposited On: | 10 Mar 2008 13:29 |
Refereed?: | No |
Published?: | Published |
Last Modified: | 07 Jan 2015 21:44 |
Identification Number: | |
URI: | http://eprints.lancs.ac.uk/id/eprint/4375 |
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Law poll:Title 8. Health Insurance And Other Health Coverages. Subtitle E. Benefits Payable Under Health Coverages from Chapter 1371. Coverage For Certain Prosthetic Devices, Orthotic Devices, And Related Services (Texas)
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Snow showers and cold temperatures are expected to linger through today. Temperatures in the Greeley area will be in the 20s to mid-30s. Warm air arrives later in the week and temperatures will be in the 60s by the weekend.
PHOTO STORY: Spring snow blankets Greeley
Trending in: Business
Trending Sitewide
- Weld sheriff, Greeley police embracing social media in public safety missions
- Slawpy Barn food truck starts in Greeley (video)
- FDIC levies fines against New Frontier Bank directors
- Larimer County Sheriff's Office rules out possible suspect, continues investigation into I-25 shooting
- Taste of Home Cooking School to host spring cooking demonstrations in Eaton, Gilcrest


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This award honors individuals who have demonstrated leadership and commitment on a national level to the advancement of racial and ethnic minorities and other under-represented populations in higher education.
Established to honor Dr. Reginald Wilson, the founding director of the Office of Minority Concerns, the award recognizes individuals who have made outstanding contributions to diversity in American higher education. Charlene M. Dukes, president of Prince George's Community College (MD), was the 2014 recipient of the Reginald Wilson Diversity Leadership Award.
Nominations are now open for the 2015 Wilson Award. The award will be presented on March 12, 2015 at the closing plenary luncheon of the 97th ACE Annual Meeting in Washington, DC. Nomination review will begin December 1, 2014.
Award Recipients
For additional information, please send an email to firstname.lastname@example.com or call 202-939-9390.
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Figure 4
Stereoview of a standard OMIT map (Fo - Fc) at 3 for AMP (a) and tubercidin (b) in the ATP-binding site (molecule A). The average B factor for tubercidin is very high (61.62 Å2) as a result of very loose contacts within the ATP-binding site, leading to less well defined electron density. |


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Not So Fast
Parenting Your Teen Through the Dangers of Driving
"Despite having worked in traffic safety for three decades, I still found myself shaking in my boots when my son began driving," admitted Pam Fischer, a member of New Jersey's Teen Safe Driving Coalition. It is a familiar feeling for many parents, and one author Tim Hollister tackles directly and honestly in Not So Fast: Parenting Your Teen Through the Dangers of Driving (Chicago Review Press, September 2013). Hollister lost his son Reid in 2006 to a car crash. Reid was the driver. He was 17 years old.
Backed by research and aimed at empowering parents, Not So Fast: Parenting Your Teen Through the Dangers of Driving, is an informative and vital guide to help parents understand the causes of teen crashes and head them off each time before their teens get behind the wheel. "It's what I wish I had known before my son died," says Hollister.
The most comprehensive guide for parents, Not So Fast tackles several hot-button issues—such as texting and distracted driving; parenting attitudes (conscious and unconscious); and teen impairment and fatigue—and includes a combination of topics not found in other teen driving guides, such as:
- How brain development affects driving
- How teen driver laws work and why Driver's Ed does not produce safe drivers
- How to negotiate a teen driving agreement
- How and when to say "No"
- And why it's imperative for parents to evaluate their teen driver on every car trip before handing over the keys.
Tim Hollister has become a national authority and spokesperson for safer teen driving since losing his 17-year-old son Reid in a car crash in 2006. After serving on a Connecticut state task force that overhauled the state's teen driver laws, Tim launched "From Reid's Dad," a national blog for parents of teen drivers. He has appeared on national and regional media, most recently on "Raising America" on HLN. Tim Hollister was awarded the 2012 AAA Southern New England Traffic Safety Hero of the Year Award as well as the U.S. Department of Transportation National Public Service Award, the nation's highest civilian award for traffic safety.


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We stock these Fuel Pump Relay brands for the Mercury Mystique: Motorcraft.
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Item delivered next day, even choosing "base" shipping method, but shipping box and parts box partially crushed (likely shipper's issue), parts not damaged.


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UMMS Affiliation
Meyers Primary Care Institute; Department of Family Medicine and Community Health
Document Type
Medical Subject Headings
Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Minority Groups; *Patient Satisfaction; *Physician-Patient Relations; Socioeconomic Factors
Health Services Research | Primary Care
CONTEXT: While pervasive racial and ethnic inequalities in access to care and health status have been documented, potential underlying causes, such as patients' perceptions of their physicians, have not been explored as thoroughly.
OBJECTIVE: To assess whether a person's race or ethnicity is associated with low trust in the physician.
DESIGN, SETTING, AND PARTICIPANTS: Data were obtained from the 1996 through 1997 Community Tracking Survey, a nationally representative sample. Adults who identified a physician as their regular provider and had at least 1 physician visit in the preceding 12 months were included (N = 32,929).
MAIN OUTCOME MEASURE: Patients' ratings of their satisfaction with the style of their physician and their trust in physicians. The Satisfaction With Physician Style Scale measured respondents' perceptions of their physicians' listening skills, explanations, and thoroughness. The Trust in Physician Scale measured respondents' perceptions that their physicians placed the patients' needs above other considerations, referred the patient when needed, performed unnecessary tests or procedures, and were influenced by insurance rules.
RESULTS: After adjustment for socioeconomic and other factors, minority group members reported less positive perceptions of physicians than whites on these 2 conceptually distinct scales. Minority group members who lacked physician continuity on repeat clinic visits reported even less positive perceptions of their physicians on these 2 scales than whites.
CONCLUSIONS: Patients from racial and ethnic minority groups have less positive perceptions of their physicians on at least 2 important dimensions. The reasons for these differences should be explored and addressed. Arch Fam Med. 2000;9:1156-1163
Citation: Arch Fam Med. 2000 Nov-Dec;9(10):1156-63.
At the time of publication, Barry Saver was not yet affiliated with the University of Massachusetts Medical School.
The AFM content is copyright American Medical Association (AMA) and licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License according to http://www.clockss.org/clockss/Archives_of_Family_Medicine#Creative_Commons_License.
Related Resources
Repository Citation
Doescher, Mark P.; Saver, Barry G.; Franks, Peter; and Fiscella, Kevin, "Racial and ethnic disparities in perceptions of physician style and trust" (2000). Meyers Primary Care Institute Publications and Presentations. Paper 553.


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After Nick Markakis led off the seventh with a single, Guerrero lined an 0-2 pitch from Nats starter Jordan Zimmermann (2-5) into left field that just cleared the fence for a 2-1 O's lead.
Koji Uehara pitched a scoreless eighth and Kevin Gregg notched his eighth save for Baltimore, which took the rubber match of a three-game series with their National League rivals.
Orioles starter Chris Tillman held Washington to one run on six hits over five innings and Jim Johnson (3-1) was credited with the victory.
Zimmermann took the hard-luck loss, yielding only Guerrero's homer among four hits in 6 1/3 frames.
Alex Cora provided the Nats' only RBI.


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Thursday, June 18, 2009
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A semi frequent look at games played by the Red Sox, Razorbacks, and Cowboys with other sports issues thrown in for good measure. Look for Day By Day at bottom of page.
2004 was the sweetest, but 2007 was divine!!
Dandy Don, Staubach, Aikman and now Tony Romo!!!
Soooooiiiiie, Pig, Soooooiiiieeee!!!
Watch the Series, Watch the Movie!!!!


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Learn more about VisionTek Killer 2100 Gaming Network Card:
Maximum Networking Performance for Online Games Forged with the perfect blend of gaming passion and technical know-how, the Bigfoot Networks Killer 2100 Gaming Network Card is quite simply the fastest network card available for online games. Game Networking DNA Automatically classifies and accelerates traffic to and from your game faster than any other desktop, networking product on the planet. See which applications are hogging bandwidth and tune performance for each, so they don't interfere with your game. Provides per-application control to block programs that access the network for increased performance and safety. Monitor and manage the health and performance of your gaming rig with graphical displays, detailed logging and a completely redesigned user interface. Measure total networking bandwidth and monitor real-time usage details for each application, so you can optimize your online gaming experience. |


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Two leading news programs on Channel 2 are being axed immediately due to financial problems at the station, its news department announced Tuesday, and its major 8 P.M. news broadcast has been cut from an hour to a half hour as of Tuesday night.
Cash-strapped Channel 2 axes two major news programs
'Six O'Clock with Oded Ben Ami' and 'Meet the Press' being scrapped.
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(10 quotes found)
"This meeting will be very decisive whether we will be able to reach a consensus."
Rene Fasel
"We're going to have the same level at least -- if not stronger,"
"I'm very, very pleased to see how it works in the NHL. That's the way we should play the game all the time."
"It's nice that he is coming, now that he doesn't have much to do."
" The only deadline that exists comes from the International Olympic Committee, which wants each federation to hand in rosters by the end of January."
"Some athletes are thinking about maybe not signing with an NHL club just to give them the opportunity to play in the Olympics in Turin."
"This is the third consecutive Olympics where we will have NHL players and NHL referees. This IIHF-NHL cooperation ... provides possibilities that are beneficial to the game. Sometimes we learn from them, sometimes they learn from us."
"I hope he will be here, and I hope he answers questions about the illegal betting."
"It took Sweden's men 64 years to beat Canada at the Olympics, and I can promise you it won't take the women 64 years to win."
"I think Vancouver will be sensational. Canadians love winter sports."


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The State-run Rashtriya Ispat Nigam's (RINL) Rs 2,500-crore initial public offer (IPO) is unlikely to hit the market in current fiscal as it has to start the process anew following expiry of the offer document filed with SEBI.
"The company had filed red herring prospectus with SEBI on October 8 hoping to launch IPO on October 16. Now, it has gone past three months and with this, it has lost validity.
This calls for submission of documents afresh which take some time," a Steel Ministry official said.
"Taking the time required for RINL to file offer document into consideration, it is unlikely that the issue will be launched within the current fiscal," he added.
The RINL issue has already been deferred thrice since the filing of the draft prospectus with market regulator SEBI on May 18 last year.
First, it was put on hold as a result of volatile market conditions and then due to a major explosion, which took place during the trial of a new oxygen control unit near the steel melting shop at Vizag Steel Plant (VSP).
Finally, in October last year, it was deferred following disagreements on the pricing of issue with merchant bankers.
The issue was supposed to kick-start the government's Rs 30,000-crore disinvestment process for the current fiscal that has mopped up a little over Rs 6,900 crore so far. Ten PSUs that include Oil India, NTPC, BHEL and SAIL are on the list of the government's disinvestment programme.
RINL is the second largest state-owned steel maker in the country producing three million tonnes per annum (mtpa) at its lone facility at Visakhapatnam. The capacity is being raised to 6.3 mtpa in the current fiscal.
The Cabinet Committee on Economic Affairs in January had approved disinvestment of 10 per cent of government's 100 per cent stake in the firm.


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Teacher slaying suspect charged in June assault
UPDATED 6:11 PM EDT Jul 09, 2014A 15-year-old Danvers boy charged with killing his teacher last year faces new charges after an assault on a state youth services staffer.
Video TranscriptA HEARING SET IN FALL RIVER. BREAKING NEWS RIGHT NOW. THE TEENAGER ACCUSED OF KILLING A DANVERS HIGH SCHOOL TEACHER IS FACING NEW CHARGES TONIGHT. AND NEWSCENTER5'S PHIL LIPOF HERE WITH MORE ON THE VIOLENT ACCUSATIONS, PHIL. 15-YEAR-OLD PHILLIPS CHISM IS NOW CHARGED WITH ATTEMPTED MURDER, KIDNAPPING AND ASSAULT AND BAT RAY. THE CHARGES STEM FROM AN ALLEGED ASSAULT EARLY NEXT MONTH. PROSECUTORS SAY HE ATTACKED A FEMALE STAFFER AT THE YOUTH SERVICES FACILITY. HE IS ACCUSED OF FOLLOWING HER INTO A BATHROOM AND CHOKING HER. EARLIER COURT RECORDS INDICATE THE ATTACK WAS IN FACT PLANNED.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Study with POLSIS and you'll have the opportunity to hear from high profile speakers on current affairs and issues.
The Department of Political Science and International Studies (POLSIS) regularly attracts high level speakers to talk directly to students, including UK government MPs and members of the US Congress. Recent speakers have included David Miliband MP, The Speaker of the House of Commons, John Bercow, and Alistair Darling, former Chancellor of the Exchequer.
As well as attending talks by high profile speakers, you will also have the opportunity to be involved in the organisation of the events. Students from both our departmental societies, The Politics Society (POLSOC) and the Chamberlain Club, organise regular events throughout each term; involvement in these activities can help to broaden your career horizons and help you to develop the key employability skills that employers are looking for.
Future events include lectures by Brigit Anderson, Deputy Director of the University of Oxford's Centre on Migration, Policy and Society (COMPAS), and Zygmunt Bauman, Professor Emeritus at the University of Leeds.
If you would like further details of these events and/or you are a student in POLSIS and wish to become a committee member for the next academic year, please contact Dr Stephen Bates (firstname.lastname@example.com).
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This week, I am going to try to answer some questions on this show! Why is the President of the USA purposely disrespecting our military veterans? What is he trying to do? Why did Barack Obama close the WWII memorial to U.S. Military veterans, but open another closed memorial to Illegal Alien Protestors? Why is the American Mass Media silent as the President and Democrats take America hostage to demand more out-of-control Trillion Dollar spending? Will Republicans snatch Defeat from the Jaws of Victory in the budget battle?
If America Defaults on our debt payments, can Obama be impeached? Do we have a President who is getting closer every day to becoming a Dictator? Have we ever had a more dishonest President? How happy are the average Americans now that Obamacare is being implemented? Has Barack Obama ever been influenced by Marxist ideology? Has Barack Obama ever agreed with Marxist ideology? Is he implementing it in America? As Americans are dragged kicking and screaming towards a socialist (communist) goverment in America - will they stand up and fight in the streets - WILL YOU?
What will happen if congress refuses to approve an increase in the debt ceiling and we go into default? Why do the political Elites in America seem to be afraid of the new constitutionalists in Congress? Could it be that we are beginning to win the country back from them? Tune in and find out. These topics and More!
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EA confirmed that Star Wars: Battlefront will be at the Electronic Entertainment Expo this year and fans are expecting a noteworthy reveal this time, considering that what they got last year is just a little teaser. Hopefully, DICE has already made progress in bringing back this beloved game.
"People don't want another Battlefield with Star Wars graphics; they want a Star Wars game that is proper," DICE executive producer Patrick Bach told Videogamer.
After last year's E3 event, EA Games Label president Frank Gibeau told investors that Star Wars Battlefront 3 "has a third-person component to it." On the other hand, apart from the expected third-person gameplay, fans are also hoping for a multiplayer footage but DICE might not deliver given the numerous issues EA had with Battlefield 4 launch.
In a sense, Battlefield's 4 is a pseudo-beta for Star Wars: Battlefront 3 and the formers woes are the latter's gain. For instance, DICE announced that it has already decided to upgrade its servers to deal with the current Battlefield 4 lag issues.
"We're unhappy with our server performance, so we'll be upgrading the hardware as soon as possible, investing more to deliver a better experience," DICE announced on the Battlefield blog. "As soon as we know the exact timetable, we'll let you know the ETA."
Moreover, DICE has also explained that it has been working on its netcode, which is another fundamental aspect of the multiplayer experience that is being tested on the Battlefield 4 ahead of the possible Star Wars: Battlefront 3 release date next year.
EA is cooking up something new for the Star Wars: Battlefront 3 and expect to do what Warner Bros. did with the Arkham series.
"What Warner Bros. did with Batman was take the core roots of that IP and manifest that inside the walls of Gotham City and delivered an interactive experience that had real ties to what you would see in the films and what you had read in the comics, while having its own life because it could provide such deep and more immersive storylines," EA's CEO Andrew Wilson told Fortune.
"When we look at the Star Wars properties that's how we're looking at it. We're not trying to build a game that replicates the storyline of any particular film."


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Brush Up On Your Bill Cosby Before This Weekend's Arena Theatre Gig
It's hard to believe that legendary comedian and public speaker Bill Cosby is 75. It's even harder to believe that The Cosby Show has been off the air since 1992.
This Sunday night Dr. Cosby plays the Arena Theatre.
Tickets are still on sale too, and the venue is small enough to make for a fun and intimate show.
Maybe he will bring along Mortimer Icobod Marker for old times sake.
Lurking around on YouTube you can find a great deal of his work, tons of talk-show appearances, and some crazy German-dubbed episodes of The Cosby Show.
Can't get enough Cosby, Instant Cosby has literally thousands of GIFs of the man fluttering his eyes, smiling, or grimacing. Consider your day over.
Cosby's calm, fatherly sarcasm doesn't translate well to the German tongue, but it is good for a laugh or three.
The older he gets the more outspoken he has also gotten on social issues too, which doesn't always rub longtime fans the right way, but that's what makes him so fun. You don't expect the Jell-O dude to drop bombs about race and class warfare at this age.
Bill Cosby: Himself
Chocka cake!
Bill Cosby: 49
Bill Cosby - On Prejudice, 1971
Very early Bill Cosby
Die Bill Cosby Show
Picture Pages, Picture Pages, Time to get your Picture Pages, Time to get your crayons and your pencils..."
"You can play with Picture Pages, FIll your day with Picture Pages, 'Till Bill Cosby does another Picture Page with you!"
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Holiday toys your kids want to see under tree
UPDATED 12:23 PM EST Nov 25, 2012Check out the toys that are sure to bring a smile to every kid's face this year.
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Tabitha - posted on 02/09/2010 ( 24 moms have responded )
I am only 7 weeks and I had an ultrasound Friday(5th) and they said that the baby was really too early to tell anything. But I had go and by maternity shirts because everything is getting to tight in my chest, hips and butt areas. Is this normal?
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Clinical and Research Experience with Locking Taper Plateau Design Implants
Thursday, November 3, 2011PresenterRainier Urdaneta, DMDCourse OverviewThis lecture will present the technique for the restoration of single tooth implants with integrated abutment crowns as well as the results of a retrospective evaluation of this restoration. The effect of increased crown to implant ratio on single tooth implants will be discussed as well as the findings from several studies in the subject. The local and systemic factors that have been associated with crestal bone stability and bone gain around single-tooth implants will be presented. These factors include the daily intake of commonly used medications. The rationale for the use of short implants and advantages over conventional implants as well as a literature review on the effect of forces in peri-implant bone will be presented. The findings of a retrospective study on the survival of Ultrashort implants will also be presented. ObjectivesAt the end of this course the participants will be able to: LocationUDM School of Dentistry Corktown Campus, Detroit, MI Times2:00 PM to 5:00 PM; Registration table opens half an hour before the course begins. CDE Credits3 hours (Lecture) | ||
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