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Dec. 21: Carnegie Mellon Researchers Discover Mechanism for Cell Receptor Recycling
Dec. 15: Obituary: CMU's Robyn Dawes Transformed Psychological Sciences; Helped Found the Behavioral Decision Research Field
Dec. 14: Two People Receive Kidney Transplants In Pilot Program Using CMU Software
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Dec. 9: Carnegie Mellon's Manuela Veloso Named IEEE Fellow for Developing Robot Teams
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Dec. 9: CMU's Green Design Institute Shares Green Tips for Harried Holiday Shoppers
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Dec. 15: Obituary: CMU's Robyn Dawes Transformed Psychological Sciences; Helped Found the Behavioral Decision Research Field
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> Dec. 15: Obituary: CMU's Robyn Dawes Transformed Psychological Sciences; Helped Found the Behavioral Decision Research Field
Shilo Raube / 412-268-6094 /
CMU's Robyn Dawes Transformed Psychological Sciences;
Helped Found the Behavioral Decision Research Field
Robyn Dawes
, the Charles J. Queenan Jr. University Professor of Psychology at Carnegie Mellon University who helped establish the field of behavioral decision research and made a significant impact in several areas of psychological sciences, died Dec. 14 at age 74.
"Robyn was an academic pioneer whose scholarship and leadership brought distinction to the university. His high standards and commitment to interdisciplinary teaching and research were deeply emblematic of Carnegie Mellon," said CMU President Jared L. Cohon.
Dawes was one of the most distinguished researchers in behavioral science and significantly advanced the understanding of how people think, learn, judge and decide. Dawes was known for research in several areas, including characterizing the limits to judgment for experts and lay people, as well as the conditions that encourage people to cooperate with one another. He also became well known as a critic of clinical psychology practices not supported by empirical research.
"Robyn was a giant in the field of psychology, constantly pushing the boundaries and taking a fresh, innovative approach to real problems," said
John Lehoczky
, dean of the
College of Humanities and Social Sciences
. "He helped create the area of behavioral decision research — an intellectual field that merged psychology and economic theory and that has since given us behavioral economics. His contributions to his research, Carnegie Mellon and his students are impossible to measure. His legacy will live on through the Department of Social and Decision Sciences, which he built."
Dawes received his bachelor's degree in philosophy from Harvard University in 1958. After taking a class in experimental psychodynamics, Dawes became interested in psychological problems from an empirical perspective. He attended the University of Michigan for his post-graduate work, earning a master's degree in clinical psychology in 1960 and a doctorate in mathematical psychology in 1963. His first faculty appointment was at the University of Oregon, where he taught psychology and served as department head.
In 1985, Dawes joined the Carnegie Mellon faculty as a professor of psychology and head of the Department of Social Sciences. He embarked on establishing a core in decision-making, a discipline that his own research had helped to define.
"Robyn actually put the 'decision' into Carnegie Mellon's Social and Decision Sciences Department, and his leadership and research set the stage for us becoming a world-class presence in this area," said
John H. Miller
, head of the
Department of Social and Decision Sciences
. "His research gracefully transcended the social sciences, having major impacts on the fields of economics, political science and psychology."
Dawes work in debunking myths and the views of self-proclaimed experts was based in the concern for humanity that motivated his research. As a member of the National Research Council's Committee on AIDS Research in the 1990s, Dawes fought the unfounded misconception that needle exchange programs — which can reduce the spread of HIV among intravenous drug users — promote drug abuse. In his book "
House of Cards: Psychology and Psychotherapy Built on Myth
," Dawes called out mental health professionals for ignoring empirical research in favor of techniques that do not hold up to scientific inquiry.
Baruch Fischhoff
, the Howard Heinz University Professor of Social and Decision Sciences and Engineering and Public Policy, was influenced by Dawes' work when he was a graduate student in the early 1970s. Fischhoff later became Dawes' colleague at Decision Research, in Eugene, Ore., and then at Carnegie Mellon. "Robyn was a great man, scientist and intellectual, who devoted his career to creating a psychology that makes the world a better place," he said. "He was fearless in seeking the truth and in fighting those who would subvert it. He was a hero to those with the good fortune to know him."
Dawes authored several books including "
Mathematical Psychology: An Elementary Introduction
," one of the first text books on the topic, "
The Fundamentals of Attitude Measurement
" and "
Everyday Irrationality: How Pseudoscientists, Lunatics and the Rest of Us Fail to Think Rationally
During the course of his career, Dawes earned many honors including the American Psychological Association's William James Award in 1990 for his book "
Rational Choice in an Uncertain World
," an induction into the
American Academy of Arts and Sciences
in 2002 and an elected fellowship to the
American Statistical Association
in 2006. In 2005, the
American Psychological Society
honored his lifetime of scientific contributions with a Festschrift, a collection of essays about his work written by colleagues from around the country.
Dawes is survived by his wife Mary Schafer; his two daughters, Jennifer Dawes of Pittsburgh, Pa., and Molly Meyers of Eugene, Ore.; two grandchildren, Kaylynn Meyers and Avery Meyers; and two cousins, Marcia Meadows of Mesa, Ariz., and Jane Hill of Eureka, Calif.
A memorial service is planned for Jan. 29, 2011, at the First Unitarian Church in Pittsburgh. Contributions may be made in Dawes' memory to Transitional Services, Inc., 806 West St., Homestead, PA 15120.
For more information on the acclaimed career of Robyn Dawes, watch an interview with him that was made in conjunction with his Festschrift at
Pictured above is Robyn Dawes, the Charles J. Queenan Jr. University Professor of Psychology.


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FSU Social Work Graduates Pass Basic Exam at Better Rate than National Average
Candidates who fail the Basic Examination may repeat the exam more than once. In 2001, three students who had failed in previous attempts retook the exam; two passed. Nationally, only 39 percent of candidates who repeat the tests pass them, nearly half of the FSU rate of 67 percent.
One hundred percent of the candidates passed the exam the first time in five of the past eight years. In those eight years, only five FSU candidates out of 72 total have failed the exam on the first try.
"Pass-fail rates for the licensure exams are just one of the instruments we use to monitor how well the program does in preparing students to become professional social workers," said Dr. Baxter Wright, chair of the FSU Department of Social Work. FSU social work graduates do well on other exams as well.
Starting in the spring of 2002, the State of Maryland allows students in the last semester of their senior year take the exam, which FSU is encouraging. "While I would like to see 100 pass rate, I would rather see our students feeling comfortable taking the exams," Wright said.
Passing the Basic Examination is one of several requirements that must be met to be licensed at the first, bachelor's degree level of social worker. For more information about FSU's Social Work program, call the Department of Social Work at (301) 687-7497.
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Board Positions
As a current board member and our treasurer I want to encourage everyone
to consider joining the board, especially colleagues from outside the
US. Board membership is a great experience.
With the help of this growing community we are trying to build a home
for the development of the discipline and a place for each of us to
grow, network and learn.
Critical aspects for the next phase of development for IxDA are maturing
to a level where we have successful transitions in leadership and that
we include ideas and voices from around the planet.
Please consider joining us!
-----Original Message-----
From: discuss-bounces at lists.interactiondesigners.com
[mailto:discuss-bounces at lists.interactiondesigners.com] On Behalf Of
Elizabeth Bacon
Sent: Thursday, Dec 13, 2007 10:06 AM
To: Interaction_Designers
Subject: [IxDA Discuss] (no subject)
Dear IxDA constituency,
The IxDA Board is seeking energetic, motivated candidates for several
open Board positions starting in early 2008. The Board comprises nine
volunteers. There are presently four executive positions: President,
Vice-President, Secretary and Treasurer, each of whom are elected
from among the Board members. The remaining Board members are
Directors. Each Board member serves for a two-year term, and turnover
is staggered so that 4 or 5 members carry over every year. We
recently instituted a consecutive two-term limit (but after one term
off the Board, an individual is eligible to rejoin).
IxDA Board members have some common responsibilities, including:
* Contributing a minimum of 3 hours (but often 5) per week to
IxDA business
* Attending monthly conference calls
* Participating actively in Board discussions and votes (via
email and online forums)
* Contributing financially to IxDA during fund-raising events
* Attending the annual Board retreat (which may involve expenses
on the order of several hundred dollars but may alternately be paid
by the organization)
Additionally, Board members are expected to chair or join committees
for various initiatives, so they are positioned to become leaders in
the field. Today's initiatives range from support of local groups to
technology infrastructure development & brand stewardship to
conference planning to...your favorite cause that advances the
profession of interaction design!
We hope you will consider applying for a Board member position! Being
an IxDA Board member is a rewarding experience on many levels.
Extensive networking opportunities abound, and you garner increased
visibility within the community. If you have any questions about the
role, please don't hesitate to write us with your questions at board-
If you are interested in applying, please send your responses to all
of the questions below to: board-app(at)ixda(dot)org before December
28, 2007. In this application, we're looking for some background
information about yourself and your professional history, as well as
learning about your positions regarding IxDA. During the application
process, a committee of Board members will review all submissions.
Final candidates will be chosen by majority vote of the full Board.
(Please note that your application for Board membership is construed
as understanding and acceptance of the Board member responsibilities
listed above.) We intend to invite candidates to join the Board on or
around January 15, 2008, and announce the new Board at our
Interaction 08 conference in Savannah on February 8-10, 2008. If
you're chosen, your presence at this conference is strongly
encouraged (but not mandated) since it will be an invaluable time to
forge connections with the rest of the Board and the organization as
a whole.
Reply soon!!
Director, IxDA
Background Information
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Genre/Form: | Fiction Mystery fiction |
Additional Physical Format: | Online version: Pears, Iain. Immaculate deception. New York : Scribner, ©2000 (OCoLC)606571053 |
Material Type: | Fiction, Internet resource |
Document Type: | Book, Internet Resource |
All Authors / Contributors: |
Iain Pears |
OCLC Number: | 45231771 |
Description: | 221 pages ; 25 cm |
Responsibility: | Iain Pears. |
More information: |
As Flavia di Stefano, acting head of Italy's Art Theft Squad, works to retrieve a stolen painting without publicity or payment, her husband, art historian Jonathan Argyll, is preparing a birthday gift: "the provenance of a small Renaissance painting, an Immaculate Conception," that hangs on a friend's wall.--Jacket.
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I Can Hear the Savior Calling
By Darian Krimm
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I Can Hear the Savior Calling composed by Darian Krimm. Arranged by Joseph M. Martin. For SATB choir. Commitment, Discipleship. General. Octavo. Published by Hope Publishing Company (HP.C5859).
This reflective text speaks of the Savior's call to "come and follow," finding comfort in sorrow, safety in the Shepherd's grace, and hope and peace amidst the storms of life. This prayerful ballad maintains comfortable vocal ranges throughout, is easily learned, and especially useful for themes of discipleship and commitment.
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Brewsky's Jazz Underground Lower level of Brewsky's Food & Spirits 201 North 8th Street, Lincoln NE In Lincoln's Historic Haymarket 7:30 - 10:00 PM Great music, food, & fun. Audience members are encouraged to bring their instruments and sit in with the band. It's a wonderful way to spend a Monday evening!
Adult Admission: $6
Student Admission: $5
Only $3 if you bring your instrument and sit in!


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Desirable 289 with 4 barrel carburetor, power steering, power top and automatic transmission. Newly chromed bumpers, and cosmetic freshening after being in storage for many years. Original California black plate goes with car.
1958 Chevy Impala $70,000
29 JanNo expense was spared on this beautiful black classic, total frame-off restoration. The interior is all new materials in original tri-color turquoise, black and silver. New black carpet and all new window glass. All interior and exterior trim is new or completely refinished. Factory new 454 big block engine, Sanderson headers, Flowmasters, March serpentine belt pulley system, Vintage Air air conditioning, heavy duty radiator with additional electric fan cooling and much more. Most engine components are chromed or polished aluminum. Turbo 700 4-speed automatic transmission, front disc brakes and custom ET wheels. Modern day performance and comfort.
1955 Chevy Custom Panel Delivery
18 AugRare 1955 1st Series Panel Delivery. Ground-up custom restoration. Modern chassis with independent front suspension, power steering, power disc brakes, front and rear sway bars, and custom rims. Custom interior with power bucket seats, tilt steering and overhead console. Vintage Air air conditioning and heat. 350cid Chevy V8 with 700R4 automatic overdrive transmission. Very comfortable and reliable cruiser.
1957 Ford Ranchero $35,995
13 MayCalifornia car from new. Phenomenal restoration of a correct car. Original 292 V8 car with automatic transmission. Upgraded Ford 302 V8 engine with dress up kit. Factory power steering and factory power brakes with fronts upgraded to disc brakes. Factory options include AM radio, heater as well as power steering and brakes. All options work correctly. The restoration was done to show standards. The body was stripped to metal and all bodywork was professionally done starting with a rust free car. The bed floor looks like new with new stainless hardware. The whole body was primed and blocked three times before using PPG urethane paint. The car was painted complete inside and out, color sanded and polished. Every piece of chrome trim and stainless were also restored and polished to show standards. The bumpers, bumper guards and grill were all re-chromed. The Ranchero hood has been louvered and antenna is frenched in on the fender giving the car a sleeker yet very original and correct look. The Ranchero has new mirrors, door handles, emblems and tail light lenses. All new interior with correct rare bull emblems on door panels. New kick panels and carpet, arm rests and rock scuff plates. It has all new tinted glass including windshield. All new rubber moldings around windows. The doors were taken apart and latches and regulators lubed and repaired. There have been hundreds of hours spent on restoration over a three year period.
1968 Camaro Z/28 RS
3 FebThis highly correct Rally Green Z/28 RS features the correct matching numbers 302/290hp engine, with all casting numbers, date and suffix codes correct to the car and matching the VIN. Great features include the original aluminum intake with 800cfm Holley dual-feed carburetor, Muncie 4-speed transmission, 12-bolt rear end with 4-leaf rear springs, 15″x6″ Rally wheels with E70x15 Goodyear tires, special gauge package including 6,000rpm tach, console mounted gauge cluster, clock, wood grain steering wheel and 4-piston power disc brakes. Front and rear bumper guard, front and rear spoilers and the functional Cowl Induction hood round out the exterior. Solid, rust-free and highly correct, this Z/28 is one of just 7,199
1960 El Camino $35,000
28 JanA lifelong southern vehicle recently restored including paint, trim, interior and mechanicals. A rare option truck including the correct date coded 348cid engine with 3×2 carburetors (HA code). Vehicle was stripped and painted to its original color. Bright work has been reconditioned and is excellent. The dash was stripped and painted. All gauges work including clock. The engine bay has been detailed using many of the original date coded parts. Carburetor's have been rebuilt with upgraded linkage and still retains its original silencer air cleaner. New exhaust, new brakes and freshened engine. Other unique options include power steering, power brakes and a new set of Coker radial large white wall tires. This 1960 El Camino is a solid high end driver rated vehicle.
1961 Ford Econoline Pickup $34,000
11 SepOne of the most unusual new concepts of design is illustrated by this 1961 Econoline truck. This truck was just completed with custom compliments such as upholstery, American Racing wheels and wide whites. This is a forward control vehicle that boasts the description of "Deluxe Pickup." The deluxe pickup included a long list of interior options but the most prominent option is the rear corner windows. The exterior color is a custom pearl silver paint. The upholstery includes upgraded sports seats, gray and burgundy in color with black piping. Headliner is gray with a burgundy overhead console. Panels and inserts are throughout the cab. The truck is powered by the original straight 6 engine with a 3-speed manual transmission. Another addition is a Flowmaster dual exhaust system. Wheels have been resized from 13″ to 14″.
1937 Cadillac Lasalle Custom 2 Door Coupe $49,995
11 SepThis 1937 Lasalle boasts a 1971 Cadillac 472cid V8 and an automatic transmission connected to a General Motors 10-bolt, leaf spring connected rear end. The bright orange paint is accented heavily with gold pearl which glows in the sunlight. The car has air conditioning, cruise control, tilt wheel, power steering and brakes. It rolls on 18″ BOSS 338 wheels and is guided by a Nova subframe, a spectacular Resto-Mod.
1986 Ferrari Mondial Convertible $39,000 SOLD!
23 JulThis Ferrari Mondial 3.2 Cabriolet has true 2+2 seating. It is possible to sit (in the rear seat) one or two average-sized adults for short to mid-distance drives, and children or smaller adults for longer drives. In 1985, the Mondial Cabriolet received the 3.2 Liter engine from the 328GTB. This boosted the horsepower and reduced the 0-60 time significantly. The new engine provides 270 horsepower and allows 0-60 to be done in 6.8 seconds. This car has only 12, 500 original miles. Underpinnings closely mirrored those of the GT4, with a sturdy tubular steel chassis, independent suspension, transversely mounted 3.2 liter V8 and 5-speed gearbox. In two notable changes, the wheelbase was lengthened some 4″ (100mm) for better interior packaging and space, and a separate subframe carried the engine and transmission. This latter item allowed the drivetrain to be unbolted and removed more quickly for easier servicing. Ferrari, in 1982, installed its new quattrovalvole (four valve) V8. The change injected real snap into the Mondial's performance. Motor magazine ran the 1982 four-valve Mondial to 60 mph in 6.4 seconds and to 100 mph in 16.2. In 1984, the Mondial Cabriolet debuted and was the first convertible Ferrari since the Daytona Spyder. The Mondial 3.2 appeared in 1985, the redesignation signifying a larger, stronger V8 (3.2 liters, 260-270 hp, as seen in the 328 GTB & GTS).
1955 Chevy Nomad $95,000
15 FebThis car underwent a full body-off restoration to original specifications and was stored in a showroom ever since. Matching numbers, rust-free California car which was in storage for 30 years before restoration. The car underwent a complete driveline and mechanical rebuild. It has a 265/180hp 4 barrel Power Pack engine with a Powerglide transmission and all new power brake system. The exterior was stripped and refinished in original turquoise and India Ivory paint. All chrome was newly plated, rubber replaced and stainless restored like new. The interior has white with turquoise waffle pattern upholstery and panels. The car has turquoise carpet throughout with turquoise linoleum covering the cargo area as original with all stainless trim polished and chrome trim newly plated. A host of factory and dealer options include Power Pack V8, power steering, power brakes, power front seat, power windows, five white wall tires, bumper guards, spot light mirror, tissue dispenser and more. One of the 6,103 Nomads produced in 1955.
1955 Buick Riviera $75,000
11 OctThis was a frame-off restoration which took three years to finish where the car was completely torn down. Everything was done from the frame up, all original parts, has original radio, motor which was rebuilt, transmission rebuilt, stripped of every part and completely redone. The interior was done in red and white leather. This Buick was in Hemmings 2010 Collector Car calendar for the month of December. At the Buick National Car show in July of 2009 in Colorado Springs, it received a 393 score and won the Senior Gold Award, the trunk liner and package tray has been completed since. In 2009, at the Buick-Oldsmobile-Pontiac show in Scottsdale, the Buick won the Best in Show. There has been numerous awards in Iowa, Arizona and Wisconsin.


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Liar, Liar, Jury's the Trier? The Future of Neuroscience-Based Credibility Assessment and the CourtJohn B. MeixnerNorthwestern University - School of Law; Northwestern University - Department of Psychology May 30, 2011 Northwestern University Law Review, Vol. 106, No. 3, 2012 Abstract: Neuroscience-based credibility-assessment tests have recently become increasingly mainstream, purportedly able to determine whether an individual is lying to a certain set of questions (the Control Question Test) or whether an individual recognizes information that only a liable person would recognize (the Concealed Information Test). Courts have hesitated to admit these tests as evidence for two primary reasons. First, following the general standard that credibility assessment is a matter solely for the trier of fact, courts exclude the evidence because it impinges on the province of the jury. Second, because these methods have not been rigorously tested in realistic scenarios, courts rule that they do not meet the Daubert criteria for admissibility of expert testimony. This Comment argues that while neuroscience-based credibility-assessment methods should not currently be admissible under the Daubert standard, they may become admissible with more research, and the courts should avoid creating precedent that would preclude their admissibility once reliability issues are addressed. Specifically, credibility assessment should not be left entirely to the trier of fact because social science evidence indicates that laypeople are poor at making credibility-assessment judgments based on behavioral cues. Additionally, even if courts continue to rule that evidence assessing whether a witness is telling the truth invades the province of the jury, this should not preclude neuroscience-based credibility assessment that merely shows that an individual recognizes something related to the issue at hand. Number of Pages in PDF File: 38 Keywords: Evidence, Scientific Evidence, Concealed Information Test, Control Question Test, Psychology, Social Science, Lie Detection, Daubert Date posted: June 10, 2011 ; Last revised: November 20, 2012Suggested CitationContact Information
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Identity |
Other names | Autotaxin | |
PD1alpha | ||
lysophospholipase D | ||
HGNC (Hugo) | ENPP2 | |
LocusID (NCBI) | 5168 | |
Atlas_Id | 40455 | |
Location | 8q24.12 | |
Location_base_pair | Starts at 120569317 and ends at 120651106 bp from pter ( according to hg19-Feb_2009) [Mapping] | |
Local_order | Telomeric to NOV (nephroblastoma overxpressed gene), centromeric to TAF2; colocalized with pseudogene CYCSP23. |
Note | mRNA length 3276 or 3120 bp, depending upon alternate splicing. |
ENPP2 Gene: Intron-exon organization of ENPP2. | |
Description | The ENPP2 gene is 81,754 bp in length and is composed of 26 exons. Part of exon 1 and 26 are untranslated (UTR); translation extends from the remainder of exon 1 through the proximal portion of exon 26; however, there is a 152 bp exon (exon 12) that is alternatively spliced and is included primarily in neurally derived tissues. |
Transcription | The mRNA for ENPP2 is 3276 bp with exon 12 and 3120 bp without it. The ENPP2 promoter is reported to have four SP1 sites as well as binding sites for NFAT and NF-kappaB but no TATA or CAAT boxes. The only transcription factor that has been proven to increase ENPP2 protein expression is NFATC2/NFAT1, after release of alpha6beta4 from hemidesmosomes in a breast cancer cell line. A number of growth factors have been found to stimulate ENPP2 protein expression, while several inflammatory cytokines have been reported to inhibit expression. |
Pseudogene | CYCSP23 |
Protein |
ENPP2 Protein (NPP2/ATX): Organization of domains and other critical elements within ENPP2. | |
Description | The ENPP2 protein, NPP2 or ATX, is an N-glycolsylated member of the ecto-nucleotide pyrophosphatase and phosphodiesterase (NPP) family of proteins. The NPP2 precursor contains 915 amino acids, 105.2 KDa; and an alternately spliced variant is 863 amino acids, 99.0 KDa. The amino terminal signal peptide sequence is cleaved at a signal peptidase site between G27 and F28 to yield a secreted protein that contains 888/836 amino acids, 102.3/96.9 KDa. NPP2 contains up to 3 ASN-linked glycosylation sites that appear to be required for secretion as well as for stabilization of its active conformation. |
Expression | NPP2 is expressed in many tissues during development, but it is critical for blood vessel maturation and neurogenesis. Certain inflammatory cytokines and the tumor suppressor CST6 downregulate ENPP2 expression, and some of the NPP2 products exert a negative feedback on its expression. Conversely, a number of growth factors as well as EBV infection (in Hodgkin's lymphoma) upregulate ENPP2 expression. Disruption of hemidesmosomes in breast cancer cells releases alpha6beta4, which initiates a signaling cascade that culminates in the activation of the transcription factor NFAT1, which binds to the ENPP2 promoter to upregulate protein expression. Upregulation of ENPP2 has been reported in a number of aggressive tumors, including glioblastoma, undifferentiated anaplastic thyroid carcinoma, invasive breast carcinoma, and metastatic hepatocellular carcinoma. In adults, NPP2 is the major source of serum and plasma lysophospholipase D activity. It is also highly expressed in brain, kidney, liver, ovary, small intestine, and placenta, and is present in many other tissues. |
Function | NPP2 is a Type 2 nucleotide pyrophosphatase and phosphodiesterase that also has ATPase activity. In addition, NPP2 is the major source of serum and plasma lysophospholipase D activity, hydrolyzing lysophosphatidylcholine into lysophosphatidic acid as well as cyclic phosphatidic acid. NPP2 also hydrolyzes sphingosylphosphorylcholine into sphingosine-1-phosphate; however, NPP2 is not a major source of sphingosine-1-phosphate in plasma. The production of lysophosphatidic acid is thought to account for many of the physiological and pathological roles of ENPP2. Both enzymatic activities of NPP2 share a common catalytic domain. Like other members of the NPP family, NPP2 is a metallo-enzyme with binding sites for 2 metal atoms coordinated by three critical histidines (H316, H360, and H475) and associated aspartates (D172, D312, and D359). T210 is nucleotidylated during the nucleotide pyrophosphatase/phosphodiesterase reaction and is essential for hydrolysis of substrate during the lysophospholipase D reaction as well. |
Homology | NPP2 is a member of the nucleotide pyrophosphatase and phosphodiesterase family, which includes ENPP1 (PC1) and ENPP3 (B10). Although the catalytic domain is highly conserved within this family of proteins, only NPP2 possesses lysophospholipase D activity. |
Mutations |
Note | There are a number of single nucleotide polymorphisms (SNPs) that have been reported within the ENPP2 gene but none are yet reported to be associated with altered phenotype. However, knockout of ENPP2 is lethal in mice (approximately E12), therefore mutations associated with loss of function might be lethal. |
Implicated in |
Entity | Various cancers |
Disease | Overexpression of the ENPP2 protein has been associated with tumor cell motility and invasion, tumor growth and metastasis, and blood vessel formation. |
Prognosis | ENPP2 is over-expressed in poorly differentiated non-small cell lung carcinomas and invasive and metastatic hepatocellular carcinoma. In thyroid carcinomas, ENPP2 expression was found to be higher in undifferentiated anaplastic thyroid carcinoma cell lines and tissues than in follicular thyroid carcinomas or goiters. When glioblastoma multiforme cells were collected from tumor cores vs. areas of white matter invasion, ENPP2 was found to be overexpressed predominantly at the invasive front. |
Oncogenesis | Upregulation of NPP2 expression appears to be associated with cancer progression rather than with oncogenesis. Transfection of ENPP2 cDNA into mouse fibroblast cell lines (NIH3T3 clone7) did not result in tumorigenic cell lines, but transfection into Ras-transformed fibroblasts resulted in rapidly growing, hematogenous, highly metastatic tumors. NPP2 expression was found in Hodgkin's lymphoma cells as well as in CD30+ anaplastic large-cell lymphomas. In the Hodgkin's lymphomas , EBV infection was correlated to induction of ENPP2 expression (P = 0.006). Transfection of the tumor suppressor CST6 into MDA-MB-435 cells resulted in down-regulation of ENPP2. In contrast, down regulation of ENPP2 by specific siRNAs resulted in down-regulation of the tumor suppressors, thrombospondin-1 and thrombospondin-2 (THBS1 and THBS2, respectively). |
Entity | Diabetes |
Disease | NPP2 expression is highly upregulated during adipocyte differentiation and its product, lysophosphatidic acid, stimulates proliferation in preadipocytes. In genetically obese, diabetic mice, NPP2 expression was increased in adipose tissue compared to their lean siblings. This is a possible model for type 2 diabetes, which has a strong genetic component. |
External links |
Bibliography |
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. |
Stracke ML, Krutzsch HC, Unsworth EJ, Arestad A, Cioce V, Schiffmann E, Liotta LA |
The Journal of biological chemistry. 1992 ; 267 (4) : 2524-2529. |
cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. |
Murata J, Lee HY, Clair T, Krutzsch HC, Arestad AA, Sobel ME, Liotta LA, Stracke ML |
The Journal of biological chemistry. 1994 ; 269 (48) : 30479-30484. |
Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2). |
Kawagoe H, Soma O, Goji J, Nishimura N, Narita M, Inazawa J, Nakamura H, Sano K |
Genomics. 1995 ; 30 (2) : 380-384. |
Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxin. |
Lee HY, Clair T, Mulvaney PT, Woodhouse EC, Aznavoorian S, Liotta LA, Stracke ML |
The Journal of biological chemistry. 1996 ; 271 (40) : 24408-24412. |
Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells. |
Lee HY, Murata J, Clair T, Polymeropoulos MH, Torres R, Manrow RE, Liotta LA, Stracke ML |
Biochemical and biophysical research communications. 1996 ; 218 (3) : 714-719. |
Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities. |
Clair T, Lee HY, Liotta LA, Stracke ML |
The Journal of biological chemistry. 1997 ; 272 (2) : 996-1001. |
Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma. |
Kawagoe H, Stracke ML, Nakamura H, Sano K |
Cancer research. 1997 ; 57 (12) : 2516-2521. |
Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2). |
B§chner D, Ahrens M, Schrder D, Hoffmann A, Lauber J, Betat N, Steinert P, Floh© L, Gross G |
Developmental dynamics : an official publication of the American Association of Anatomists. 1998 ; 213 (4) : 398-411. |
Developmental expression analysis of murine autotaxin (ATX). |
B§chner D, Ahrens M, Betat N, Schrder D, Gross G |
Mechanisms of development. 1999 ; 84 (1-2) : 121-125. |
Autotaxin expression in non-small-cell lung cancer. |
Yang Y, Mou Lj, Liu N, Tsao MS |
American journal of respiratory cell and molecular biology. 1999 ; 21 (2) : 216-222. |
Expression of autotaxin mRNA in human hepatocellular carcinoma. |
Zhang G, Zhao Z, Xu S, Ni L, Wang X |
Chinese medical journal. 1999 ; 112 (4) : 330-332. |
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells. |
Nam SW, Clair T, Campo CK, Lee HY, Liotta LA, Stracke ML |
Oncogene. 2000 ; 19 (2) : 241-247. |
Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases. |
Gijsbers R, Ceulemans H, Stalmans W, Bollen M |
The Journal of biological chemistry. 2001 ; 276 (2) : 1361-1368. |
Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor. |
Nam SW, Clair T, Kim YS, McMarlin A, Schiffmann E, Liotta LA, Stracke ML |
Cancer research. 2001 ; 61 (18) : 6938-6944. |
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells. |
Lee HY, Bae GU, Jung ID, Lee JS, Kim YK, Noh SH, Stracke ML, Park CG, Lee HW, Han JW |
FEBS letters. 2002 ; 515 (1-3) : 137-140. |
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. |
Tokumura A, Majima E, Kariya Y, Tominaga K, Kogure K, Yasuda K, Fukuzawa K |
The Journal of biological chemistry. 2002 ; 277 (42) : 39436-39442. |
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. |
Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, Yamori T, Mills GB, Inoue K, Aoki J, Arai H |
The Journal of cell biology. 2002 ; 158 (2) : 227-233. |
Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. |
Yang SY, Lee J, Park CG, Kim S, Hong S, Chung HC, Min SK, Han JW, Lee HW, Lee HY |
Clinical & experimental metastasis. 2002 ; 19 (7) : 603-608. |
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. |
Clair T, Aoki J, Koh E, Bandle RW, Nam SW, Ptaszynska MM, Mills GB, Schiffmann E, Liotta LA, Stracke ML |
Cancer research. 2003 ; 63 (17) : 5446-5453. |
Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. |
Ferry G, Tellier E, Try A, Gr©s S, Naime I, Simon MF, Rodriguez M, Boucher J, Tack I, Gesta S, Chomarat P, Dieu M, Raes M, Galizzi JP, Valet P, Boutin JA, Saulnier-Blache JS |
The Journal of biological chemistry. 2003 ; 278 (20) : 18162-18169. |
Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination. |
Fox MA, Colello RJ, Macklin WB, Fuss B |
Molecular and cellular neurosciences. 2003 ; 23 (3) : 507-519. |
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site. |
Gijsbers R, Aoki J, Arai H, Bollen M |
FEBS letters. 2003 ; 538 (1-3) : 60-64. |
Site-directed mutations in the tumor-associated cytokine, autotaxin, eliminate nucleotide phosphodiesterase, lysophospholipase D, and motogenic activities. |
Koh E, Clair T, Woodhouse EC, Schiffmann E, Liotta L, Stracke M |
Cancer research. 2003 ; 63 (9) : 2042-2045. |
Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun. |
Black EJ, Clair T, Delrow J, Neiman P, Gillespie DA |
Oncogene. 2004 ; 23 (13) : 2357-2366. |
Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. |
Brindley DN |
Journal of cellular biochemistry. 2004 ; 92 (5) : 900-912. |
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. |
Hama K, Aoki J, Fukaya M, Kishi Y, Sakai T, Suzuki R, Ohta H, Yamori T, Watanabe M, Chun J, Arai H |
The Journal of biological chemistry. 2004 ; 279 (17) : 17634-17639. |
Expression, regulation and function of autotaxin in thyroid carcinomas. |
Kehlen A, Englert N, Seifert A, Klonisch T, Dralle H, Langner J, Hoang-Vu C |
International journal of cancer. Journal international du cancer. 2004 ; 109 (6) : 833-838. |
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells. |
Baumforth KR, Flavell JR, Reynolds GM, Davies G, Pettit TR, Wei W, Morgan S, Stankovic T, Kishi Y, Arai H, Nowakova M, Pratt G, Aoki J, Wakelam MJ, Young LS, Murray PG |
Blood. 2005 ; 106 (6) : 2138-2146. |
Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. |
Boucher J, Quilliot D, Prad®res JP, Simon MF, Gr®s S, Guign© C, Pr©vot D, Ferry G, Boutin JA, Carp©n© C, Valet P, Saulnier-Blache JS |
Diabetologia. 2005 ; 48 (3) : 569-577. |
Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. |
Chen M, O'Connor KL |
Oncogene. 2005 ; 24 (32) : 5125-5130. |
Footer: a quantitative comparative genomics method for efficient recognition of cis-regulatory elements. |
Corcoran DL, Feingold E, Dominick J, Wright M, Harnaha J, Trucco M, Giannoukakis N, Benos PV |
Genome research. 2005 ; 15 (6) : 840-847. |
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. |
van Meeteren LA, Ruurs P, Christodoulou E, Goding JW, Takakusa H, Kikuchi K, Perrakis A, Nagano T, Moolenaar WH |
The Journal of biological chemistry. 2005 ; 280 (22) : 21155-21161. |
The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide. |
Koike S, Keino-Masu K, Ohto T, Masu M |
Genes to cells : devoted to molecular & cellular mechanisms. 2006 ; 11 (2) : 133-142. |
Autotaxin stimulates urokinase-type plasminogen activator expression through phosphoinositide 3-kinase-Akt-nuclear [corrected] factor kappa B signaling cascade in human melanoma cells. |
Lee J, Duk Jung I, Gyo Park C, Han JW, Young Lee H |
Melanoma research. 2006 ; 16 (5) : 445-452. |
Identification of large-scale molecular changes of Autotaxin(ENPP2) knock-down by small interfering RNA in breast cancer cells. |
Noh JH, Ryu SY, Eun JW, Song J, Ahn YM, Kim SY, Lee SH, Park WS, Yoo NJ, Lee JY, Lee SN, Nam SW |
Molecular and cellular biochemistry. 2006 ; 288 (1-2) : 91-106. |
The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin. |
Song J, Jie C, Polk P, Shridhar R, Clair T, Zhang J, Yin L, Keppler D |
Biochemical and biophysical research communications. 2006 ; 340 (1) : 175-182. |
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. |
Tanaka M, Okudaira S, Kishi Y, Ohkawa R, Iseki S, Ota M, Noji S, Yatomi Y, Aoki J, Arai H |
The Journal of biological chemistry. 2006 ; 281 (35) : 25822-25830. |
Cyclic phosphatidic acid is produced by autotaxin in blood. |
Tsuda S, Okudaira S, Moriya-Ito K, Shimamoto C, Tanaka M, Aoki J, Arai H, Murakami-Murofushi K, Kobayashi T |
The Journal of biological chemistry. 2006 ; 281 (36) : 26081-26088. |
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. |
van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Prad®re JP, Pettit TR, Wakelam MJ, Saulnier-Blache JS, Mummery CL, Moolenaar WH, Jonkers J |
Molecular and cellular biology. 2006 ; 26 (13) : 5015-5022. |
Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase. |
Prad®re JP, Tarnus E, Gr®s S, Valet P, Saulnier-Blache JS |
Biochimica et biophysica acta. 2007 ; 1771 (1) : 93-102. |
Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma. |
Savaskan NE, Rocha L, Kotter MR, Baer A, Lubec G, van Meeteren LA, Kishi Y, Aoki J, Moolenaar WH, Nitsch R, Br§uer AU |
Cellular and molecular life sciences : CMLS. 2007 ; 64 (2) : 230-243. |
Contributor(s) |
Written | 02-2007 | Mary L. Stracke, Timothy Clair |
Citation |
This paper should be referenced as such : |
Clair, T ; Stracke, ML |
ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2) |
Atlas Genet Cytogenet Oncol Haematol. 2007;11(3):182-185. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Genes/ENPP2ID40455ch8q24.html |
Clair, T ; Stracke, ML. ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2). Atlas Genet Cytogenet Oncol Haematol. 2007;11(3):182-185. |
http://documents.irevues.inist.fr/bitstream/handle/2042/38434/02-2007-ENPP2ID40455ch8q24.pdf |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Apr 15 08:49:02 CEST 2015 |
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Alright so I got a 1tb hardrive that I recently formatted as a Fat32 (compatible with ps3) I was wondering if I can network it with my Airport extreme and have it work on my Macbook my girlfriends PC laptop and my ps3?
Also I don't know much about Fat32 but I read somewhere it can't access filies over 30gb or something of that nature, does this mean if I a folder that I put my movies in it can't exceed 32gb? |
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Member Since: Jan 29, 2008
Location: Mendocino, CA
Posts: 680
Mac Specs: 17" MacBook Pro A1151 2.16 GHz
I've never heard such a thing. FAT32 doesn't support individual files larger than 4GB, but there shouldn't be any limit on how much data is stored in a folder. Maybe you were thinking of the Windows 2000 disk formatter's 32GB volume limitation.
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Rounding the bases: The best bets in the bigs Every week we take a look at the hottest and coldest teams as well as the best over and under bets in major league baseball. Hot team: San Francisco Giants Last week: 6-1 Season record: 89-64 Upcoming schedule: vs. Diamondbacks, at Padres Skinny: The Giants won six in a row last week and clinched a playoff spot before falling 6-4 Sunday to the Padres. Cold team: Colorado Rockies Last week: 0-7 Season record: 58-94 Upcoming schedule: vs. Diamondbacks, vs. Cubs, at Dodgers Skinny: The end of the season can't come soon enough for the Rockies. Colorado has lost nine straight, dropping games to San Diego, San Francisco and Arizona. Over team: Colorado Rockies Last week: 6-1 Season O/U record: 78-68-5 Upcoming schedule: vs. Diamondbacks, vs. Cubs, at Dodgers Skinny: Rockies pitchers rank dead last in the bigs in nearly every statistical category, while their hitters rank in the top 10 in most offensive stats. A perfect recipe for an over bet. Under team: Cincinnati Reds Last week: 5-0 Season O/U record: 58-81-13 Upcoming schedule: vs. Brewers, at Pirates Skinny: Mat Latos tossed eight shutout innings against the Dodgers on Saturday to help the Reds clinch the NL Central for the second time in the last three seasons. Their pitching staff ranks third in ERA (3.39), which is a major reason why they've been an awesome under bet all season long.
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Monday's streaking and slumping starting pitchers STREAKING Marco Estrada, Milwaukee Brewers (4-6, 3.56) Estrada threw seven scoreless innings against the Pirates as the Brewers won 3-1 on Wednesday. The righty now has 13 2/3 scoreless innings over his last two starts with 10 strikeouts. He certainly has momentum for his next outing against the Nationals. Trevor Cahill, Arizona Diamondbacks (12-11, 3.89) Cahill only gave up two runs over six innings against the Padres on Wednesday to pick up his 12th win of the campaign. The right-hander has claimed victories in each of his last three starts, allowing two runs in each of those. He toes the rubber against the lowly Rockies next. SLUMPING Ricky Romero, Toronto Blue Jays (8-14, 5.72) Romero had lost 13 straight decisions, matching a franchise record prior to a no-decision in his last start versus the Yankees. Although the lefty is showing signs of improvement, he hasn't picked up a win since June 22 in Miami. He draws the red-hot Orioles in the second game of a doubleheader next. Tyler Chatwood, Colorado Rockies (4-5, 5.73) Chatwood gave up three runs on eight hits over four innings of a 7-1 loss to the Giants on Saturday. The 22-year-old hurler has only thrown more than five innings in one of his 10 starts this year. He pitches opposite Cahill and the Diamondbacks on Monday.
MLB Hot pitchers -- Estrada is 2-1, 1.75 in his last four starts. Zimmerman is 2-0, 2.50 in his last three outings. -- Lynn is 2-0, 0.73 in his last couple starts. -- Cahill is 3-0, 2.79 in his last three starts. -- Verlander won his last two starts, tossing 13 shutout innings. -- Chen is 0-0, 2.84 in his last couple starts. SJohnson won both his '12 starts, allowing two runs in six IP. Last start was August 25. -- Straily is 2-0, 2.08 in two road starts this season. Holland is 2-0, 2.17 in his last four starts. -- Sale is 2-1, 1.93 in his last three starts. -- Pettitte is 2-1, 2.89 in his last six starts. Cold pitchers -- McPherson lost his first start, allowing two runs in 4.1 IP. Mejia lost his first start, allowing five runs in three IP. -- Abad is 0-5, 6.97 in his last five starts. -- Chatwood is 0-2, 8.62 in his last four starts. -- Hochevar is 1-3, 8.04 in his last five starts. -- Alvarez is 2-6, 6.52 in his last nine starts. Romero is 0-6, 6.69 in his last seven outings. -- McAllister is 0-4, 7.94 in his last five starts. -- Hendriks is 1-1, 4.71 in his last five starts. Hot Teams -- Brewers won 25 of their last 32 games. -- Cardinals won six of their last seven games. Astros are actually 8-8 in their last sixteen games. -- Arizona won six of its last seven games. -- Royals won four of their last five games. -- Orioles won six of their last seven games. -- Bronx won nine of its last 11 games. Minnesota won four of six. Cold Teams -- Washington lost six of its last nine games. -- Pirates lost 12 of their last 16 games. Mets lost 10 of their last 14. -- Rockies lost 16 of their last 18 games. -- Tigers lost three of their last four games. -- Blue Jays lost ten of their last twelve games. -- Athletics lost five of their last seven games. Texas is 4-9 in game following its last 13 wins. -- White Sox lost their last five games, scoring eight runs. Indians lost 11 of their last 15 games. Totals -- Over is 15-7-1 in last 23 Milwaukee games. -- Under is 21-11-1 in Mets' last 33 games. -- Seven of last eleven St Louis games stayed under total. -- 12 of last 14 Colorado games went over the total. -- Six of last eight Detroit games went over the total. -- Four of last five Baltimore games stayed under total. -- Six of last seven Oakland games went over the total. -- Five of last seven Cleveland games went over the total. -- Under is 8-5-1 in last fourteen Bronx road games.


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Gandhi's Life – Part 01
February 21, 2002 | Posted by Staff under Biographies |
Biography of M.K. Gandhi
A Child Groom
The word Mahatma means great soul. This name was not given Gandhi at birth by his parents, but many years later by the Indian people when they discovered they had a Mahatma in their midst.
Gandhi was born on October 2, 1869, in Porbandar, a small state in western India. He was named Mohandas Karamchand Gandhi. The word Gandhi means grocer, and generations earlier that had been the family occupation. But Gandhi's grandfather, father, and uncle had served as prime ministers to the princes of Porbandar and other tiny Indian states, and though lower caste, the Gandhis were middle-class, cultured, and deeply religious Hindus.
Gandhi remembered his father as truthful, brave, incorruptible, and short-tempered, but he remembered his mother as a saint. She often fasted for long periods, and once, during the four months of the rainy season, ate only on the rare days that the sun shone.
At the age of six Gandhi went to school in Porbandar and had difficulty learning to multiply. The following year his family moved to Rajkot where he remained a mediocre student, so sensitive that he ran home from school for fear the other boys might make fun of him.
When Gandhi was thirteen, he was married to Kasturbai, a girl of the same age. Child marriages, arranged by the parents, were then common in India, and since Hindu weddings were elegant, expensive affairs, the Gandhi family decided to marry off Gandhi, his older brother, and a cousin all at one time to spare the cost of three separate celebrations.
At first the thirteen-year-old couple were almost too shy to speak to each other, but Gandhi soon became bossy and jealous. Kasturbai could not even play with her friends without his permission and often he would refuse it. But she was not easily cowed, and when she disobeyed him the two children would quarrel and not talk for days. Yet while Gandhi was desperately trying to assert his authority as a husband he remained a boy, so afraid of the dark that he had to sleep with a light on in his room though he was ashamed to explain this to Kasturbai.
The young bridegroom was still in high school, where his scholarship had improved, and he won several small prizes. Indian independence was the dream of every student, and a Moslem friend convinced Gandhi that the British were able to rule India only because they ate meat and the Hindus did not. In meat lay strength and in strength lay freedom.
Gandhi's family was sternly vegetarian, but the boy's patriotism vanquished his scruples. One day, in a hidden place by a river, his friend gave him some cooked goat's meat. To Gandhi it tasted like leather and he immediately became ill. That night he dreamed a live goat was bleating in his stomach, but he ate meat another half-dozen times, until he decided it was not worth the sin of lying to his parents. After they died, he thought, he would turn carnivorous and build up the strength to fight for freedom. Actually, he never ate meat again, and freed India with a strength that was moral rather than physical.
But Gandhi was still a rebellious teenager, and once, when he needed money, stole a bit of gold from his brother's jewelry. The crime haunted him so that he finally confessed to his father, expecting him to be angry and violent. Instead the old man wept.
"Those pearl drops of love cleansed my heart," Gandhi later wrote, "and washed my sin away." It was his first insight into the impressive psychological power of ahimsa, or nonviolence.
Gandhi was sixteen when his father died. Two years later the youth graduated from high school and enrolled in a small Indian college. But he disliked it and returned home after one term.
A friend of the family then advised him to go to England where he could earn a law degree in three years and equip himself for eventual succession to his father's post as prime minister. Though he would have preferred to study medicine, the idea of going to England excited Gandhi. After he vowed he would not touch liquor, meat, or women, his mother gave him her blessing and his brother gave him the money.
Leaving his wife and their infant son with his family in Rajkot, he went to Bombay. There he purchased some English-style clothing and sailed for England on September 4, 1888, just one month short of his nineteenth birthday.
Part Two
This biography was written by Roberta Strauss Feuerlicht and is reprinted here with the permission of the copyright holder.
All rights reserved. No part of this material may be reproduced or transmitted in any form or by any means, electronic or mechanical, which includes but is not limited to facsimile transmission, photocopying, recording, rekeying, or using any information storage or retrieval system.
What's your opinion? Tell your views to The Progress Report!
303 Responses to Gandhi's Life – Part 01
Very interesting.
i dont like this a lot of your statements are wrong please fix your writing and punctuation mistakes please, and thank you
i think this is boring.
good info
very bad
he was a good men
this was very good it had a lot about gandhi
This is a good biograohy and very interresting,but could you please make it shorter.
Absolutely beautiful experience. Reading this made my cry but smile too. What a gorgeous biography x
he is a nice man and a rich man too
pls. mention detail of MAHATMA GANDHI life history.
you need to add a lot more information about ghandi like what his life was like when he was a child ans stuff like that
This was very helpful, i had a Gandhi report and i this information helped me finish more than half of it
great realy good
what i asked and what have u given . i asked about studylife of gandi . there is no information on that.i feel very bad
I think this report is SUPER awesome because it's everything I'v learned.
it was good
It's not in chronological order!!!!
gandhi is agood man
Really helped my major book report for the semester
this is good story of gandhi
tell more
I admire Gandhi was one of the greatest men that ever lived and walked this earth.
In the midst of the confusion with the Imam and the Pastor in the USA , Gandhi's Movie and his life's teachings should be discussed and aired and discussed by Larry king and others on the CNN -
amazing facts!!!!
gandhi is a very good person in the world and up to now his name is live.
well i think tht it was very well written and that is was very detailed but it wasnt to long or to short but it gave you just enough information as well!


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Stans end of season stock take - Checkout functionality is currently disabled
Stans end of season stock take - Checkout functionality is currently disabled
The Vango Woburn 400 is the replacement for the old Icarus 400 and is similar in looks, layout and dimensions to that very popular tent. The Woburn 400 is a 4-berth tunnel tent with a bedroom inner curtain than can split the bedroom into a 2+2 configuration each section of which will have its own entrance door. The breathable inner tent also features the 'lights out' system which filters out early morning daylight for a more comfortable sleep.
The Vango Woburn 400 is very quick to pitch with the same length poles and head height throughout the tent making it a great weekend tent for the family or a group of friends.
The living area is a well proportioned 2.6x2.4m so providing ample living/dining space. There are two entrances off the living area - both large panel doors that can be either rolled up or propped out to form sun canopies.
The tent has a fully sewn-in polyethylene groundsheet so keeping out draughts and bugs and the interior also benefits from Vango's TBS (tension band system) - webbing straps that you can deploy to strengthen the tunnel structure in poor weather conditions.
The full features of the Vango Woburn 400 Tent include:
Pack Size | 65x29x29cm |
Weight | 12.7kg |
Width | 260cm |
Length | 210+240cm (465cm overall) |
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Berth | 4-Berth |
Colour | Atlantic Blue/Black |
Some exlusions apply, for further delivery details for all destinations click here
Vango Woburn 400 - a simple, uncomplicated tunnel tent very similar to the Icarus range.


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A Benfica Player Decked The Referee Mid-Match, And The Match Was Cancelled
That's referee Christian Fischer lying motionless on the ground, after Benfica defender Luisao somehow decked him. The match between Fortuna Dusseldorf and Benfica was cancelled at that point. This doesn't rival Dylan McGeough's injury from earlier today in seriousness, so feel free to chuckle.


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Harry Weller
General Partner, Washington DC
Harry leads NEA's east coast venture practice and is a founder of NEA's China organization. He is recognized as one of America's top venture capitalists with honors including the Forbes "Midas List," where he is among six investors named to the list since inception, Washingtonian's "Titans of Technology," Business Insider's "Top 5 East Coast VCs" and Washington Business Journal's "Outstanding Board Director Award" and "Power 100 Business Leaders." Harry is a co-founder of Harvard University's Experiment Fund and an Expert in Residence at Harvard.
Harry's past investments include Cvent (NYSE: CVT), Echo Global (NASDAQ: ECHO), Eloqua (NASDAQ: ELOQ, acquired by Oracle), GlobalLogic (acquired by Apax), Groupon (NASDAQ: GRPN), Merlin Securities (acquired by Wells Fargo), OPower (NYSE: OPWR), Pentaho (acquired by Hitachi), Riverbed Technologies (acquired by Aether Systems), SourceFire (NASDAQ: FIRE, acquired by Cisco), Vertica (acquired by Hewlett Packard), Vonage (NYSE: VG) and webMethods (NASDAQ: WEBM, acquired by Software AG).
- August 13, 2014
- March 4, 2014
- February 4, 2014
- June 7, 2013
- Midas List (multiple years) Forbes
- Titans of Technology (multiple years) Washingtonian Magazine
- Outstanding Director Award Washington Business Journal
- "Top 5 East Coast VCs" Business Insider
- "Top 20 Venture Capitalists in the World" Red Herring
- "Most Influential List" Networking World
- "Top Cloud Investors" AlwaysOn
- Venture Capital 100 AlwaysOn
- Washington Business Journal's Power 100 Washington Business Journal
Favorite Band Timeline
School House Rock
1972–1977 School House Rock
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1977–1982 The Police
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1992–1997 Jane's Addiction
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Linked by Tony Steidler-Dennison on Thu 10th Jul 2008 13:39 UTC, submitted by BlueVoodoo
Wildcards can be very confusing when it comes to generics in the Java language, and one of the most common mistakes is to fail to use one of the two forms of bounded wildcards ("? super T" and "? extends T") when needed. You've made this mistake? Don't feel bad, even the experts have, and this month Brian Goetz shows you how to avoid it.
just don't go to wild :
* List<int> primitive;
* List<Integer> array[];
* if (T instanceof String) {}
* function(List<Integer>.class);
and i have a lot of other trouble because of the type erasure. so kids, just say no and wait for the proper implementation. java generics are nothing but a fancy way to remove the casting.


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12-04-2007, 06:05 PM | #21 (permalink) | |
BoardTard Xtrordinair
Join Date: Sep 2007
Location: Colorado
Posts: 1,476
And I might be a pothead, but I've met a LOT of coked out to the gills skiers. No judgement passed. I've also seen some snowboarders that really piss me off because they just make the rest of us look worse than we are already percieved. I was a skier for probably 10 years or more before I started boarding regularily and I never had a problem with snowboarders. IMO as a skier there were a lot more "newb" skiers than boarders causing accidents. I think they forget we kind of have blind spots riding down the hill sideways. Maybe we (humans) all just piss eachother off, especially in large groups lol. |
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12-05-2007, 05:12 AM | #22 (permalink) |
Join Date: Aug 2007
Location: Only British blaady Columbia!!!
Posts: 4,622
traditionally speaking, skiing was an exclusive past time; economically exclusive. and so this band of old schoolers, who are still out there, are having to come to terms with an on hill population that has exploded in numbers due to accessibility and popularisation, but also who entertain this 'new fad' of going sideways.
for sure they perceive a 'fuck you' attitude; they think we have blind spots and larger turning circles and to an extent this might be true for some of us; but this is of little to no consequence. if it is, then i suggest they have inadequate skills to be there themselves! the point is, this 'arsehole' label is one of perception. skiers want to perceive us as being punks, just as we want to see them as being stuck up pricks. it is a preconceived stereotype, where we try to identify a common foe, to reinforce kinship between those who are similar to us. a pack mentality. this is intrinsic to human nature and despite me knowing this, i still feel that in all of my on hill encounters, there have been far more poncy skiers than boarders. for eg. if i cut up a snowboarder, they might shake their head at me, but i will apologise and ALWAYS they tell me "no worries". if i cut up a skier, they have slagged me off before i have even inhaled to word an apology. (french ski instructors are the absolute kings at this!) it is all down to a will to see the worst in those who are different to your self. simple human nature.
Just coz you don't understand it Doesn't mean it makes no sense! |
12-05-2007, 05:45 AM | #23 (permalink) |
Posts: n/a
i dunno, wherever i ride, i usually find that riders/skiers' main problem is that they regard other people on the mountain more as "cones" or obstacles to practice how close they can carve by you rather than as people and offering safe riding/skiing practice and personal space. i mean, how many times have you been chillin on teh side of a slope or taking a casual ride down and had some chump try and throw some snow in your face by plowing 3 inches away from you?
12-05-2007, 07:20 AM | #24 (permalink) |
Posts: n/a
when i was younger, say 3-8 years old, i was a skier and my entire family was a bunch of skiers. when i was about 9 or so i was at the point in my life where it wasnt cool anymore to do what all the old people and my little sister were doing on the mountain, and i always saw these really cool lookin dudes cruisin down the sides of the run on snowboards...thats what i wanted to be, i wanted to be that guy. As i got better and better i realized that 90% of all snowboarders share the same hard chargin mentality. How many boarders have you met that just wanna cruise the blues all day long and then call it a day around 3:00? Skiers on the other hand seem more conservative, there will always be the people that dont fit this steriotype but mostly i think its a fairly acceptable idea.
A few years ago i had a friend of mine that was just learning to ride. He was on a green just trying to get his heelside down without faceplanting and he got going a little faster than he was comfortable with and lost control. He was haulin ass lol and he was headed right for this older gentlemen(i use the term loosely) and his young boy who were both on skis. He was going to hit one of them so he plowed the old man(he probably would have killed the kid) and the man of course was irate. I pulled up in time to hear the old man chewing my friends ass as my friend apologized over and over again and even stepped out of his board to go uphill and get the mans sunglasses. The old man kept saying that he shouldnt be here and this was for people trying to learn. My friend then sortof lost it and said "well what the FU*K do you think i'm doin here?!?" Then the old man said some things about how snowboarders shouldnt be here and they are too dangerous and blah blah blah. we've all met that guy. but lots of skiers have met that piece of shit guy on a snowboard as well. |
12-05-2007, 10:37 AM | #25 (permalink) |
Veteran Member
Join Date: Sep 2007
Location: Hicksville, NY
Posts: 1,846
I was having this conversation yesterday in the gondola at Stratton with my skier buddy who is a self proclaimed snowboard hater obviously him and I are very good friends and go ride the mountain together so his argument for his disliking of snowboarders is that as previously stated we all always seem out of control on the mountain. Also because there are many of us that will push ourselves on terrain we can't really handle yet we have a tendency to just slide down the mountain on our heel edge thus ruining the terrain for the people who can handle it. My response to him was basically that I think the problem lies in the fact that there are just way more "new" snowboarders than there are skiers so there much less overall experience riding the mountain on a snowboard. Also new snowboarders do tend to take up more space on the slope than do skiers due to most making very wide turns as we learn to link and get more comfortable turning in a smaller radius. Skiers overall mountain footprint is smaller as the turning principles are just different from snowboarders.
He did agree with what I was saying and I think that lightened his perception more. In terms of the attitude, there are plenty of shitty people that both ski and snowboard so it really just comes down to the person |
12-05-2007, 10:49 AM | #26 (permalink) | |
Join Date: Aug 2007
Location: Only British blaady Columbia!!!
Posts: 4,622
Just coz you don't understand it Doesn't mean it makes no sense! |
12-05-2007, 10:55 AM | #27 (permalink) | |
Join Date: Sep 2007
Location: Frederick, MD in other words to far from the big mountains
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12-05-2007, 11:39 AM | #28 (permalink) |
Veteran Member
Join Date: Sep 2007
Location: Hicksville, NY
Posts: 1,846
thing is this about the mogul fields... to skiers it's not a problem they use them to turn which is why they exist... for us snowboarders they're a big pain in the ass. I agree with you guys but just figured I'd post his opinion as well
12-05-2007, 12:04 PM | #29 (permalink) |
Join Date: Aug 2007
Location: Only British blaady Columbia!!!
Posts: 4,622
truth be told (and don't tell the skiers) i don't really mind mogul fields....
you can use them to bank turns off of as well, and the ones with a bit of flat behind them make super wicked jumps! holy schmeg i have broken the sound barrier a good few times from hopping moguls! they're like whoop-dee-doos!
Just coz you don't understand it Doesn't mean it makes no sense! |
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Top 5 careers for working mums
If you're wondering if it's time for a career change, here are some options that might suit. more
8 easy, family friendly recipes each week
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These apple fangs look scary and are a great addition to your Halloween entertaining table. These healthy bites will balance out the sweet consumption that goes with Halloween.
10 mins
0 mins
Using a sharp paring knife, cut each quarter in half and slice V shapes in the top and bottom of the adjoining edges so it looks like your slices have "teeth".
Spread peanut butter in between the "teeth". Squeeze together your slices so the peanut butter oozes out.
Place almond slivers into the peanut butter so they look like fangs.


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Pleasant Grove Police investigate the scene where seven infant bodies were discovered and packaged in separate containers at a home in Pleasant Grove, Utah, on Sunday. / AP Photo/Deseret News, Jeffrey D. Allred
A Utah woman admitted to police that she strangled or suffocated at least six of her newborns, stuffed the bodies into cardboard boxes and hid them in the garage of her home, according to court documents released on Monday.
Megan Huntsman, 39, was arraigned Monday on six charges of murder and ordered held on $6 million bond.
When asked by Judge Steven Hansen what she thought of the size of the bail, Huntsman, speaking via closed circuit TV from the Utah County jail, stared blankly and responded, �That�s fine.�
Huntsman was arrested Sunday after police discovered the remains of the infants at a house in Pleasant Grove, Utah, where she lived until 2011.
Police said Huntsman told officers that she had given birth to at least seven babies at the house and that all but one were born alive.
According to the arrest document, Huntsman told officers that �she either strangled or suffocated the babies immediately after they were born.�
The arrest warrant released Monday said police found each of the dead infants wrapped in either a towel or a shirt, placed inside a plastic bag then put into a separate cardboard box.
The bodies were discovered by police after Huntsman�s estranged husband, Darren West, found the body of one newborn in a garage of the house that he was cleaning out. He first contacted Huntsman then called police.
Aaron Hawker, a neighbor in the town of 35,000 located 35 miles south of Salt Lake City, tell the Provo Daily Herald that West, who had been in prison on drug-related charges, was getting ready to move back into the house, which was divided into apartments for two families.
Hawker told the newspaper that he did not consider Huntsman to be a murderer.
�Personally speaking I think Megan was scared to death to have anybody find out,� he said. �Fear can really motivate you.�
Authorities say they believe West was living with Huntsman at the time of the killings, but isn�t a person of interest at this time.
�We don�t believe he had any knowledge of the situation,� Capt. Michael Roberts, Pleasant Grove police spokesman, told The Associated Press.
Asked how West could not have known about the situation, Roberts replied, �That�s the million-dollar question. Amazing.�
DNA tests on the remains will be compared to samples taken from Huntsman and West to determine whether they are the parents of the seven infants.
Another neighbor, Sharon Chipman, told The Salt LakeTribune that the couple�s three daughters were living in the house. The eldest, she said, were around 18 to 20 years old, while the youngest is about 13.
�He (West) was finally coming down to help take care of his family � and to run across that, It would devastate him,� Chipman said.
Neighbors said they were shocked not only by the news of the killings, but also simply that Huntsman could have been pregnant and gone unnoticed.
�None of us ever thought she was pregnant. She was always so skinny and there were six full-term pregnancies,� Hawker told the Daily Herald.
Kathie Hawker, Aaron�s wife, said Huntsman baby-sat the Hawker grandchildren years ago and they were friendly with each other.
�It makes us so sad, we want to cry,� Kathie Hawker said. �We enjoyed having them as a neighbor. This has just blown us away.�
Late Sunday, West�s family issued a statement saying they were in a �state of shock and confusion.�
�We are mourning this tragic loss of life and we are trying to stay strong and help each other through this awful event,� the statement said before asking for privacy.
Fred Newman, a neighbor whose cousin is the husband�s mother, said he�s perplexed how the three oldest daughters living there didn�t know about what police say was going on. He said the girls didn�t always park their cars in the garage, but did sometimes in the cold winter months.
�What�s shocking is the three older ones living there and not noticing that their mother was pregnant,� Newman said.
He said he has used his snowblower to clean off the driveway of the home and the young women would thank him.
The girls were normal youngsters, coming and going often, neighbor Vickie Nelson said.
Contributing: Associated Press


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NJ still a long way to go in recovering from Sandy's wrath
Jersey Shore devastated by hurricane's devastation
Driving onto Long Beach Island in New Jersey, the first thing you'll see are boats where they shouldn't be, a deserted highway, and the National Guard.
For fear of looting, police, the media and cleanup crews are some of the select few allowed on the island. where the damage isn't measured in homes but neighborhoods.
One woman, who didn't want to give her name, told 69 News that there is no water for those who stay.
"We have no electric, no gas. It's sporadic all over the place," said the woman, who has lived there for 40 years.
Beach home walls are now windows to the sea. Sand sits everywhere. Debris litters deserted streets, and a boat now docks in Joe Carmelengo's driveway.
"We are leaving tomorrow. All the food is bad. The refrigerator is out. We have to get rid of it," he said.
A blue home on the beach now leans after being ripped right off it stilts.
69 News photojournalist Albert Castro's family owns a home on Long Beach Island, a half-block from the beach.
"Windows are not shattered. Still in one piece," he told his wife on the phone. "Wow! So far, so good on the inside.'
Outside of some basement flooding, the home made it through. It's a small win on an island badly beaten.
Copyright 2012 WFMZ. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Posted: Wed May 2nd, 2007 09:43 pm |
javal1 Grumpy Geezer
Art, In this case I tend to agree with you - it may be time to give CWPT the benefit of the doubt. If everything said in their response to you is true, and historians and others were consulted, then I have to assume that there was no critical land (earthworks, trenches, etc.) damaged. Also hearing that no witness trees were affected goes far in making me feel better. I think the size of the track may be excessive, but I'll reserve final judgement until I see some pics. What I think a lot of Civil War enthusiasts forget is that local cooperation is vital to acquisition of Civil War land. Sometimes compromise demands that locals receive something in return, in this case a recreational trail. I also think you'll see more of this sort of thing as Franklin's projects continue to develop. Thanks for your post... (I'd also add that their quickness in replying to both of us has to be commended) |


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