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The Birches at Esopus
Seniors' New Year's Eve Ball
Sunday, January 1st, 2012Thanks to the generosity of community supporters, Kingston NY area seniors danced the night away waiting for the 2012 ball to drop. The annual New Year's Eve event was held at The Hillside Manor, a leading fine dining and events facility. Host Denni Demosthenes managed to get all guests to the table despite the many attendees who arrived up to an hour early! Over 350 seniors attended and enjoyed a full dinner and dessert, dancing to both live and DJ'd music, a champagne toast and, of course, New Year's hats and noisemakers. The music makers mixed it up with the predictable old favorites and many contemporary hits that got everyone on the floor rocking.
For the third year, the main sponsors were Birchez Associates, the Bruderhof, and the Demonthenes family which owns The Hillside Manor. Other local purveyors also helped out. For example, Adams Fair Acres Farms donated beautifully prepared (and delicious) cookie platters for each table, Deisings Bakery provided the dinner rolls.
The smiles of the seniors were evident at the festively set tables in both the full rear ballroom and the restaurants front function room. Not to be outdone by the decor, many of the ladies were "dressed to the nines." As one quipped, "Where else am I going to get the opportunity to get so dressed up. I love it!" Join the festivities via video (only a minute and a half in length) in which Birchez principals Steve and Judy Aaron welcome one and all.
Several political leaders stopped by to lend their support, most notably Congressman Maurice Hinchey who greeted many by name. Outgoing legislator Walter Frey and encumbent councilman Jimmy Bruno traveled from Saugerties. Majority Leader for the Kingston Common Council Tom Hoffay was in early attendance. Newly elected Alderperson Deb Brown, 9th ward Kingston, shared her thoughts on the video.
Seniors who attended and who would like to comment on the evening can contact us at email@example.com. We'd love to share your thoughts as we enter 2012!
Holiday Party Has Seniors Rocking to the Beat
Monday, December 19th, 2011Holidays can be lonely for seniors living on their own. But at the Birchez Associates communities, you'll find many ways to celebrate the holidays. In addition to cosponsoring the Kingston area senior New Year's Eve party (to watch video, click here), Birchez owners Steve and Judy Aaron also hosted a holiday party for all their senior residents and staff.
At The Hillside Manor, a popular dining and events destination in Kingston, Birchez took over . A decorated Christmas tree welcomed guests in the foyer, with holiday decoration throughout. Cocktails and hors d'oeuvres started the event in the front ballroom. Then festivities moved to the full back ballroom (complete with its own Christmas tree and Menorah) for dinner and dancing.
Special guests included Congressman Maurice Hinchey who spun at least one senior on the dancefloor. County Treasurer Eliott Auerbach and his lovely wife Judy, County Clerk Nina Postupak, County Legislators Peter Loughran, Hector Rodriguez and Walter Frey, as well as Town of Esopus Council members Kyle Barnett, Gloria VanVliet and Donna McAuley also joined the party.
The band leader of "Outside the Box" thought he was doing the right thing when he mentioned a 92 year old resident was on the dance floor, only to have other dancers raise their hands to say "I'm in my nineties too!" From the salad course through desert, the dance floor was in motion. Whether a classic melody or a cover of a contemporary song from Lady GaGa or Adele, guests were up and dancing. Chambers Court Resident and Centenarian Bill McDonough didn't dance but had a front row table to watch others do so.
Pointsetta centerpieces obtained through the local Boys & Girls Club were given to those residents who found a lucky penny underneath their place setting. In addition to peach melba for desert, plates of cookies from local Deising's Bakery provided some extra energy for seniors to keep the dance floor full.
And for residents who no longer drive, A.N.N. Transportation provided a handicapped bus and van to get everyone to the event. After four hours of partying, there was even some grumbling when the announcement was made that the bus and van were ready for loading to take residents home. "Already?" some were heard to exclaim!
For additional pictures, see Holiday Party album on Facebook
Birchez Associates featured on Senior Services panel
Friday, June 10th, 2011At the recent annual conference for the New York State Association for Affordable Housing (NYSAFAH), a panel on senior housing featured Birchez Associates. Speaking for Birchez were Founder & Managing Member Steven L. Aaron and Director of Marketing, K.J. McIntyre. Known to provide market rate plus services and amenities at affordable rents for seniors, Birchez Associates has built and manages four affordable senior communities in the Hudson Valley, as well as one workforce affordable community.
Entitled Serving Seniors: Innovative Ideas and Opportunities, the panel was chaired by Peter Florey of D&F Development. In addition to the Birchez representatives, the panel included Ken Harris of the NY Association of Housing & Services for the Aging, Evelyn Wolff of Selfhelp Community Services, Julie Behrens of the NYC Department of Housing Preservation & Development, and Stuart Zalka representing NYS Homes & Community Renewal.
Among services and amenities provided for residents, Birchez Associates employs a Senior Advocate, Alice Tipp, who had served for 30 years in the Ulster County Legislature and chaired the Health Services Committee. Ms. Tipp provides a knowledgable bridge to resources and services in the greater community. At residents' meetings, she frequently invites service providers to meet with the residents. Augmenting the advocacy team is the Director of Community Services, Paul Watzka.
Working with agencies such as the Ulster County Office for the Aging and Jewish Family Services, Birchez has brought services to the doorstep. Both physical and mental health issues are attended to at the Birchez Communities. This spring a mental health social worker was on hand to meet with seniors dealing with issues such as bereavement and depression and to recommend longer term services available often at no cost to the senior. One result of this has been the formation of a weekly group at The Birches at Chambers.
Physical health is improved at the Fitness Studios available at both The Birches at Chambers and The Birches at Esopus (although open to all Birchez residents). Here a specially trained senior fitness coach is available at no cost to work out at the residents ability and speed.
Augmenting amenities include Media Centers with state of the art projection and sound for the latest Indie or Classic film. Community rooms encourage gatherings, the library/game room to meet with friends, and a computer lab for instruction and free use.
The crafts room allows seniors to show off crafting ability and to learn new ones. A team of knitters created nearly 100 caps for young children this past winter at both the local neighborhood center and Sloan Kettering Cancer Hospital. Among the participants were three male seniors, two of whom were in wheelchairs. None of them had ever knitted before but they took to the project with zeal.
Steven L. Aaron, Founder & Managing Member of Birchez Associates LLC, is a board member of NYSAFAH. Birchez Associates was a Gold Sponsor for the annual conference held in New York City each spring. Birchez Associates LLC, founded in 2002, has built five affordable housing communities in the Hudson Valley.
The New York State Association for Affordable Housing (NYSAFAH), formed in 1998, the New York State Association for Affordable Housing (NYSAFAH) is the trade association for New York's affordable housing industry statewide. Our 300 members include for-profit and nonprofit developers, lenders, investors, syndicators, attorneys, architects and others active in the financing, construction, and operation of affordable housing. Together, NYSAFAH's members are responsible for virtually all of the housing built in New York State with federal, state, or local subsidies. is the trade association for New York's affordable housing industry statewide. Our 300 members include for-profit and nonprofit developers, lenders, investors, syndicators, attorneys, architects and others active in the financing, construction, and operation of affordable housing. Together, NYSAFAH's members are responsible for virtually all of the housing built in New York State with federal, state, or local subsidies.
Esopus Business Alliance Second Anniversary
Friday, June 10th, 2011The Esopus Business Alliance (EBA), formed just two years ago, supports local businesses that both operate within Esopus or those outside Esopus which support the local community. Among these is The Birches at Esopus which has hosted a networking mixer for the membership.
Now the EBA is holding its second annual celebration with a picnic mixer on June 27th from 5:30 to 7:30 on the majestic lawns of the Hudson Valley School of Massage overlooking the Hudson River. Locate at 1723 Route 9W, West Park, the school is directly across from the Stonehedge Restaurant.
Come on out for a special evening. Live (and lively) music features Earl Pardini and his group. Complimentary picnic style refreshments, lawn games, chair massages and mini-facials by the H.V.S.M.T. staff, and a champagne toast to celebrate EBA's incredible first two years. Non-members and guests are welcome. There will be a $5 per person fee for members and an $8 fee for non-members, payable at the event.
This is a rain or shine event as indoor space will be available if needed. Registration is a must. Birches at Esopus residents who would like to attend, please call K.J. McIntyre at 845-532-7528 or email her at firstname.lastname@example.com so we may add you to the guest list. Sounds like a fun event!
Case Study in Excellence: The Birches at Esopus
Wednesday, May 4th, 2011New York, NY: The New York State Association for Affordable Housing (NYSAFAH) honored Birchez Associates' affordable senior community, The Birches at Esopus, as Case Study in Excellence at a reception and presentation held in New York City at the REBNY (Real Estate Board of New York) headquarters.
Already recognized by NYSAFAH as Project of the Year — Upstate for 2010, The Birches at Esopus served as a case study in successful public and private partnership, innovative financing, and green energy efficiencies. At its ribbon cutting, the community was also acknowledged as an Energy $mart Building by NYSERDA, in part because 70% of domestic hot water and 30% of the heat comes from solar thermal panels. Further, The Birches at Esopus was one of four national finalists for Senior Project of the Year in Affordable Housing Magazine.
The panel (shown to the right) was introduced by Jay Seiden, Seiden & Schein, PC, and comprised Birchez Associates Founder & Managing Member, Steven L. Aaron, The Honorable John Coutant, Supervisor of the Town of Esopus, John Kelly, Esq. of Nixon Peabody, Marian Zucker of New York State Homes & Community Renewal, Peter King representing the Federal Home Loan Bank – NY, and Rita Wyatt Esq., principal of Wyatt & Co. Judy Wells Aaron and K.J. McIntyre both of Birchez Associates also participated in the presentation. Available for the Q&A were the Town of Esopus clerk, Diane L. McCord, town council member Gloria VanVliet and chair of the planning board Roxanne Pecora (shown in the lower left photo from right to left).
Key topics introduced both by panel participants and the audience included:
- Finding financing for affordable housing projects and how that has changed in today's economic market
- Creating market rate amenities to both attract residents and to fulfill aging in place goals
- Structuring a public – private partnership and the political courage it takes to succeed in bringing quality affordable housing to a community
- Changing environment in the now combined DHCR and nyhomes, now New York State Homes and Community Renewal
Attendees included developers, financiers, architects, attorneys and other members of NYSAFAH.
Travel article features resident of The Birches at Esopus
Friday, April 8th, 2011The Poughkeepsie Journal on April 6th covered the three-day Travel conference that focussed on the mid-Hudson River Valley as a tourist destination. Looking for ideas for The Birches at Esopus Residents' Club was Mary Jackson, who was pictured speaking with Captain Jeffrey Pyle of Empire Cruise Lines in Poughkeepsie.
The event was sponsored by two of the region's group travel-related companies, Hudson River Valley Tours and Destinations of New York State, and drew tour operators from as far as Ottawa, Canada. Judging from the buzz, we'll see many of the tour operators back with full buses and boats in the not so distant future.
The Birches at Esopus is one of four affordable senior housing communities built and managed through Birchez Associates. For more information, www.Birchez.com
For the full article, click here. PS: knowing Mary, she'll be available for autographs!
picture credit: Darryl Bautista/Poughkeepsie Journal


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Watson Confirms Exalgo(TM) Patent Challenge
MORRISTOWN, N.J., Dec. 14, 2010 /PRNewswire/ — Watson Pharmaceuticals, Inc. (NYSE: WPI) today confirmed that its subsidiary, Watson Laboratories, Inc. – Florida, filed an Abbreviated New Drug Application (ANDA) with the U.S. Food and Drug Administration (FDA) seeking approval to market Hydromorphone Hydrochloride Extended-release Tablets, 8 mg, 12 mg, and 16 mg. Watson's Hydromorphone Hydrochloride Extended-release Tablets are a generic version of Mallinckrodt Inc.'s Exalgo(TM) tablets, which are indicated for once daily administration for the management of moderate to severe pain in opioid tolerant patients requiring continuous, around-the-clock opioid analgesia for an extended period of time.
Mallinckrodt filed suit against Watson on December 10, 2010 in the United States District Court for the District of New Jersey seeking to prevent Watson from commercializing its product prior to the expiration of U.S. Patent No. 5,914,131. Mallinckrodt's lawsuit was filed under the provisions of the Hatch-Waxman Act, resulting in a stay of final FDA approval of Watson's ANDA until April 29, 2013, or until final resolution of the matter before the court, whichever occurs sooner, subject to any other exclusivities.
Based on available information, Watson believes it may be a "first applicant" to file an ANDA for the 8 mg, 12 mg, and 16 mg generic versions of Exalgo(TM) and, should its ANDA be approved, may be entitled to 180 days of generic market exclusivity.
About Watson Pharmaceuticals, Inc.
Watson Pharmaceuticals, Inc. is a leading global specialty pharmaceutical company. The Company is engaged in the development, manufacturing, marketing and distribution of generic pharmaceuticals and specialized branded pharmaceutical products focused on Urology and Women's Health. Watson has operations in many of the world's established and growing international markets.
For press release and other company information, visit Watson Pharmaceuticals' Web site at http://www.watson.com.
Forward-Looking Statement
Statements contained in this press release that refer to non-historical facts are forward-looking statements that reflect Watson's current perspective of existing information as of the date of this release. It is important to note that Watson's goals and expectations are not predictions of actual performance. Actual results may differ materially from Watson's current expectations depending upon a number of factors, risks and uncertainties affecting Watson's business. These factors include, among others, the difficulty of predicting the timing and outcome of the pending patent litigation; the impact of competitive products and pricing; the timing and success of product launches; difficulties or delays in manufacturing; the availability and pricing of third party sourced products and materials; successful compliance with FDA and other governmental regulations applicable to Watson and its third party manufacturers' facilities, products and/or businesses; changes in the laws and regulations, including Medicare and Medicaid, affecting among other things, pricing and reimbursement of pharmaceutical products; and such other risks and uncertainties detailed in Watson's periodic public filings with the Securities and Exchange Commission, including but not limited to Watson's annual report on Form 10-K for the year ended December 31,2009 and Watson's quarterly report on Form 10-Q for the period ended September 30, 2010. Except as expressly required by law, Watson disclaims any intent or obligation to update these forward-looking statements.
Exalgo(TM) is a trademark of Mallinckrodt Inc.
CONTACTS: Investors: Patty Eisenhaur (973) 355-8141 Media: Charlie Mayr (973) 355-8483
(Logo: http://photos.prnewswire.com/prnh/20100121/LA41294LOGO )
SOURCE Watson Pharmaceuticals, Inc.

subset: commoncrawl


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29/03/2012 (dd/mm/yyyy) | Barcelona
THIS EVENT HAS BEEN CANCELLED The ESADE Entrepreneurship Institute and the Alumni Entrepreneurship have launched a new series of meetings called, Last Thursdays. Their aim is to encourage networking opportunities between entrepreneurs, investors, service providers, others involved in entrepreneurial efforts, faculty, business plan sponsors and students. Last Thursdays will be the ideal platform in which to exchange ideas, share experiences and foment new business opportunities, all over an informal drink. We look forward to seeing you on 29th March at 6.30 pm at the Hotel Madarín Oriental.
Free event Drinks to be paid in situ Be sure to reserve the last Thursday of every month on your calendar*! *Next Last Thursdays: 26th April, 31st May and 28th June. For further information: 93 553 02 17 firstname.lastname@example.com
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This would be a nice addition to our running. I know coach visited this young man last week. What is our chance of landing this kid? Kendial Lawrence: Prized Prospect | Prep Ticket Scout.com: Lawrence Talks Home Visit With Coach Rhoads
Committed to Mzzou.
so i'm going to go with 0%
Originally Posted by Cy's Taxi so i'm going to go with 0% That's why I spend lunch time here, for the insights!
Forum Rules


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And the true sign of sanity and greatness is to so continue.
For the one who can achieve this, there is abundant hope.
For those who cannot, there is only sorrow, hatred and despair. And these are not the things of which greatness or sanity or happiness are made.
A primary trap is to succumb to invitations to hate.


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Released: Mar 01st, 2007
Running Time: 150
Director: Mark Stone
Company: Wicked Pictures
Kris Knight, Keeani Lei, Evan Stone, Eric Masterson, Marcos Leon, Nautica Thorn, Tommy Gunn, Jayna Oso, Syren, Avena Lee, Jazmine Lieh, Gianna Lynn
Critical Rating: AAA 1/2
Genre: Gonzo
This all-Asian edition of I'm a Tease plumbs the talent pool for babes to fit the bill, and some of them totally hit the mark.
One of those is Syren, who may move a bit too slow for some, but the way she savors the b.j. she gives Marcos Leon, making lots of eye contact with the camera, is just fine in our book – and the way she enjoys her reverse cowgirl bounce is even better.
But the next hot action doesn't occur until the fifth scene, with Gianna Lynn fingering and dildoing herself before Eric Masterson enters for kissing, reverse cowgirl, mish and spoon. Jayna Oso gets the finale (and the box), and while her teasing works, the momentum of the scene doesn't really start to rock until the reverse cowgirl anal.
Retailing: Between the "tease" theme and the Asian gals, this should move nicely.


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Price: $
Light, maneuverable and very spin friendly, the K Surge brings lots of performance from all areas of the court. Our TW playtesters were impressed by the solid feel of this racquet considering its light weight and maneuverable feel. Our testers also liked the ease of accelerating this racquet through the contact zone, allowing for a lot of spin and pace off a short swing. The K Surge offers a comfortable response, but there's still ample feedback for touch and control play. At net the racquet feels very fast and easy to maneuver. Volleys feel crisp and clean off the stringbed with both depth and directional control easy to gauge. There's ample room for weight and balance customization here, making this a great stick for players progressing towards an advanced level as they can increase weight as player technique and strength improve. All in all, this racquet provides some of the best performance in its weight class and will pleasantly surprise a lot of players who tend to prefer heftier sticks. Players at the 4.0+ level should definitely spend some court time with this one.
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From Cancer Genome Mutational Profiling, to...
Using Circulating Biomarkers for Cancer Diagnostics...
Single-Use, Hollow Fibers Cannot Transition from...
Researchers Discuss Strategies to Improve the...
(Page 1 of 2)
There is growing enthusiasm in the pharmaceutical industry for whole-system functional assays that reveal the action of potential drugs on integrated systems such as intact cells in order to find allosteric effects and off-target effects.
In target-based drug discovery, high-throughput screening (HTS) of compounds against a single defined molecular target is performed in order to identify drug candidates that can perturb the action of a cellular component that is presumed to mediate a specific phenotype. Common targets include catalytically active proteins such as kinases, phosphatases, phosphodiesterases, and proteases.
Despite the huge amount of resources put into target-based drug discovery, a disappointingly small number of drugs have been developed using this approach. This is due in part to the fact that many diseases are not caused by aberrant activities of only one target cellular component but are multifactorial. They typically involve various complex pathway interactions implicated in signal transduction and are dynamically regulated in living cells by effects such as feedback inhibition.
To complicate matters, many inducer molecules that create various phenotypes share cellular-signaling pathways with a number of endogenous regulatory molecules. As a consequence, target-based drug discovery can result in a drug with limited impact or in a drug that creates harmful side effects that are revealed only at later stages of clinical or preclinical testing.
To increase the efficiency of drug development, it is therefore advantageous to concurrently measure a network of signaling events that connect a target with a phenotype within the context of the cell. Gyrasol Technologies has addressed this challenge by developing a detection platform that measures various post-translational modifications implicated in signaling pathways simultaneously, in a single or multiplexed fashion using only one detection reagent.
These assays are homogeneous, sensitive, and adaptable to HTS and for measuring activities of endogenous enzymes in cellular lysates. In addition, since the sensor can be chemically synthesized in bulk quantities, this platform is more cost-effective than other available screening platforms.
The Gyrasol platform is based on metal ion-mediated association of a sensor to a fluorophore-labeled substrate (Figure 1). The sensor consists of a metal ion coordinated to a phosphonate-based chelator, which retains its ability to bind to phosphates present on substrates.
Upon association of the sensor to the substrate the fluorescence of the fluorophore is quenched. Because the metal-ion mediated association to phosphoryl groups is generic, the sensor can detect activities of various enzymes involved in signaling (kinases, phosphatases, phosphodiesterases, and proteases) by using various substrates such as peptides, cyclic nucleotides, DNA, or lipids within defined assay components or in lysates of cells (Figure 2). Dose responses are linear, allowing for semiquantitative data analysis using maximum or minimum controls for conversion. Alternatively, the extent of substrate conversion can be quantified using synthetic calibrator molecules.
In contrast to other commonly used metal ions that are components of enzyme activity detection platforms, the particular metal ion used in the Gyrasol Sensor can coordinate to phosphates at physiological pH. As a result, kinetic monitoring can be performed for some enzymes, simplifying mode-of-action inhibitor analysis.
Activity assays have an advantage over antibody-based phosphoprotein detection platforms since measurement of a protein modification does not necessarily correlate with modulation of catalytic activity. Additionally, phosphoprotein detection assays may miss inhibitors that modulate the activity of a protein by altering its conformation and/or intramolecular associations (allosteric effects).
Policy proposals to address the growing global problem of fake medicines include a global agreement, similar to the Framework Convention on Tobacco Control, and stricter national laws to prosecute those who knowingly sell counterfeit medicines. Do you think these steps will be successful?
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OIR Reminds That Those Called To Active Duty Can Temporarily Suspend Health Coverage
Thursday, April 03, 2003
– With many of the state's National Guard and reserve troops called up for active duty, due to the war in Iraq, the Florida Office of Insurance Regulation wants to alert these troops and their families that their health and disability income policies will not be affected.
Florida law requires the continuation of health insurance and disability income coverage following call-ups for active duty service. This requires insurance companies to maintain policies, without payment of premium, and resume them at the same coverage and premiums the insured troops had prior to being activated.
Regarding this statute, Office of Insurance Regulation Director Kevin McCarty said, "This is one concern we want our service men and women to not have to worry about."
Some insurance companies have contacted their policyholders regarding this matter. However, whether or not an insurance company contacts those affected, their coverage will be maintained.
The section of the Florida statutes referring to these protections follows:
The 2002 Florida Statutes
Title XVII
MILITARY AFFAIRS AND RELATED MATTERS Chapter 250
MILITARY AFFAIRS View Entire Chapter
250.341 Cancellation of health insurance.--Any health insurance policy, certificate, or evidence of health coverage, which was in effect on April 30, 1991, or which is issued or renewed after such date that provides coverage to a member of the Florida National Guard, or a member of any branch of the United States military reserves who is a resident of this state, called to active military duty, must:
(1) Continue all coverages which were in effect for the person, or the person's dependents covered by the same policy, at the premium in effect for all insured under the same contract, unless the employee requests coverage changes which might alter the premium he or she was paying prior to such activation during the time he or she serves on active duty.
(2) Reinstate the coverage for any such person who elects not to continue it while on active duty, at the person's request upon return from active duty, without a waiting period or disqualification for any condition which existed at the time he or she was called to active duty. Such reinstatement must be requested within 30 days after returning to work with the same employer or within 60 days if the policy is an individual policy.
(3) Any coverage available to the insured employee's dependent under the CHAMPUS program will be considered in the payment of any benefits.
(4) The employee must notify his or her employer of his or her reserve or National Guard status and the employee's intent to invoke the provisions of subsections (1) and (2) prior to leaving his or her employer to report for active military duty.
(5) Nothing in this section is intended to require an employee group health insurance policy to provide coverage to a person serving on active military duty.
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Having a self-absorbed New Age mother and an estranged father means 15-year-old Ellis Whitman has grown up relying on an unconventional guardian: a goat-trekking, marijuana-growing sage called Goat Man. So when Ellis decides to leave the alternative ways of his desert homestead for a stuffy East... Full description
Other Authors: | Neil, Christopher., Proirier, Mark Jude., Duchovny, David., Russell, Keri, 1976-, Farmiga, Vera., Kirk, Justin., Burrell, Ty, 1967-, Phillips, Graham, 1993-, Image Entertainment (Firm) |
Format: | DVD |
Language: | English |
Published: |
[United States] : Image Entertainment, 2012 |
Edition: | Widescreen. |
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Gene: | rlmA | Accession Numbers: EG12207 (EcoCyc), b1822, ECK1820 |
Synonyms: rrmA, yebH, ribosomal RNA large subunit methyltransferase A, rRNA large subunit methyltransferase A
RlmA is the methyltransferase responsible for methylation of 23S rRNA at the N1 position of the G745 nucleotide. RlmA activity is required for wild-type translation and cell growth [Gustafsson98]. The methylated base is expected to reside near the peptide exit channel in the context of the ribosome [Hansen01].
In vitro, RlmA is able to methylate free 23S rRNA, but not assembled 50S ribosomal subunits or 70S ribosomes. A 92 nt fragment of 23S rRNA consisting of stem-loops 33, 34 and 35 is efficiently methylated [Hansen01]. Specificity for the target nucleotide is determined by the methyltransferase rather than the rRNA substrate [Liu02a].
The location of the SAM-binding region and catalytic site have been predicted . RlmA is predicted to have an N-terminal zinc finger and a C-terminal substrate recognition region [Bujnicki02]. The crystal structure of RlmA has been determined at 2.8 Å resolution, and RlmA appears to be an asymmetric dimer. The Zn2+-binding domains may be responsible for RNA recognition and binding [Das04].
An rlmA mutant lacks 1-methylguanine in its rRNA [Isaksson73]. rlmA mutants exhibit defects in translation, a decreased growth rate even in rich medium, and increased resistance to the antibiotic viomycin [Gustafsson98]. However, the growth defect of an rlmA mutant is not due to lack of rRNA methylation, and thus RlmA appears to have another, as yet unidentified, function [Liu04c].
RlmAI: "rRNA large subunit methyltransferase A" [Liu02a]
Locations: cytosol
Map Position: [1,904,275 <- 1,905,084] (41.04 centisomes, 148°) | Length: 810 bp / 269 aa |
Molecular Weight of Polypeptide: 30.419 kD (from nucleotide sequence)
Unification Links: ASAP:ABE-0006067 , EchoBASE:EB2122 , EcoGene:EG12207 , EcoliWiki:b1822 , ModBase:P36999 , OU-Microarray:b1822 , PortEco:rrmA , PR:PRO_000023765 , Protein Model Portal:P36999 , RefSeq:NP_416336 , RegulonDB:EG12207 , SMR:P36999 , String:511145.b1822 , UniProt:P36999
Relationship Links: InterPro:IN-FAMILY:IPR016718 , InterPro:IN-FAMILY:IPR025714 , InterPro:IN-FAMILY:IPR029063 , PDB:Structure:1P91 , Pfam:IN-FAMILY:PF13847
In Paralogous Gene Group: 194 (13 members)
GO Terms:
MultiFun Terms: | information transfer → RNA related → RNA modification |
Essentiality data for rlmA knockouts:
Growth Medium | Growth? | T (°C) | O2 | pH | Osm/L | Growth Observations |
LB Lennox | Yes | 37 | Aerobic | 7 | Yes [Baba06, Comment 1] | |
M9 medium with 1% glycerol | Yes | 37 | Aerobic | 7.2 | 0.35 | Yes [Joyce06, Comment 2] |
MOPS medium with 0.4% glucose | Yes | 37 | Aerobic | 7.2 | 0.22 | Yes [Baba06, Comment 1] |
17-Sep-2008 by
Keseler I
SRI International
Enzymatic reaction of: 23S rRNA m1G745 methyltransferase |
Synonyms: rRNA (guanine-N1-)-methyltransferase, S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase, ribosomal ribonucleate guanine 1-methyltransferase
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
The reaction is physiologically favored in the direction shown.
Cofactors or Prosthetic Groups: Zn2+ [Das04]
Feature Class | Location | Citations | Comment | |||
Metal-Binding-Site | 5 |
| |||
Metal-Binding-Site | 8 |
| |||
Metal-Binding-Site | 21 |
| |||
Metal-Binding-Site | 25 |
| |||
Amino-Acid-Sites-That-Bind | 67 |
| |||
Protein-Segment | 96 -> 97 |
| |||
Amino-Acid-Sites-That-Bind | 183 |
Gene Local Context (not to scale):
Transcription Unit:
10/20/97 Gene b1822 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene
EG12207; confirmed by SwissProt match.
Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554
Bjork70: Bjork GR, Isaksson LA (1970). "Isolation of mutants of Escherichia coli lac king 5-methyluracil in transfer ribonucleic acid or 1-methylguanine in ribosomal RNA." J Mol Biol 51(1);83-100. PMID: 4921251
Bujnicki02: Bujnicki JM, Blumenthal RM, Rychlewski L (2002). "Sequence analysis and structure prediction of 23S rRNA:m1G methyltransferases reveals a conserved core augmented with a putative Zn-binding domain in the N-terminus and family-specific elaborations in the C-terminus." J Mol Microbiol Biotechnol 4(1);93-9. PMID: 11763974
Das04: Das K, Acton T, Chiang Y, Shih L, Arnold E, Montelione GT (2004). "Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site." Proc Natl Acad Sci U S A 101(12);4041-6. PMID: 14999102
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Gaudet10: Gaudet P, Livstone M, Thomas P (2010). "Annotation inferences using phylogenetic trees." PMID: 19578431
GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.
GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."
Gustafsson98: Gustafsson C, Persson BC (1998). "Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant." J Bacteriol 180(2);359-65. PMID: 9440525
Hansen01: Hansen LH, Kirpekar F, Douthwaite S (2001). "Recognition of nucleotide G745 in 23 S ribosomal RNA by the rrmA methyltransferase." J Mol Biol 310(5);1001-10. PMID: 11501991
Isaksson73: Isaksson LA (1973). "Partial purification of ribosomal RNA(m1G)- and rRNA(m2G)-methylases from Escherichia coli and demonstration of some proteins affecting their apparent activity." Biochim Biophys Acta 312(1);122-33. PMID: 4580201
Joyce06: Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S (2006). "Experimental and computational assessment of conditionally essential genes in Escherichia coli." J Bacteriol 188(23);8259-71. PMID: 17012394
Liu02a: Liu M, Douthwaite S (2002). "Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria." Mol Microbiol 44(1);195-204. PMID: 11967079
Liu04c: Liu M, Novotny GW, Douthwaite S (2004). "Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase." RNA 10(11);1713-20. PMID: 15388872
UniProt10: UniProt Consortium (2010). "UniProt version 2010-07 released on 2010-06-15 00:00:00." Database.
UniProt15: UniProt Consortium (2015). "UniProt version 2015-01 released on 2015-01-16 00:00:00." Database.
UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493
SRI International is an independent, nonprofit corporation. Privacy policy Disclaimer |


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Peter Farrelly
Starring: Jim Carrey Jeff Daniels
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Sales Rank: 3214
Category Keywords: Blockbuster Buddies Essential Cinema Mishaps Morons On-The-Road Recommended Slapstick Theatrical Release
See more in Comedy
Editor's Note
Lowbrow buffoonery hit commercial highs with 1994's DUMB AND DUMBER. When best friends and aspiring pet groomers Lloyd Christmas (Jim Carrey, in a star-making role) and Harry Dunne (Jeff Daniels) get fired, Lloyd convinces Harry to travel to Colorado to search for his dream woman--Mary Swanson (Lauren Holly). Little does Lloyd know that Mary's in Aspen trying to locate her kidnapped husband. Soon the dimwitted pair have gotten mixed up in the crime, and their wacky exploits are leading the FBI straight to the crooks. The Farrelly Brothers are at the peak of their twisted craft with this gut-busting comedy. But between such gross-out gags as Hary's Exlax overdose and Lloyd's deliriously over-the-top dream sequence, it's really the chemistry between Carrey and Daniels--and the charming naiveté of these two dunces--that lend the film a disarming sweetness.
Cast & Crew
Mike Starr | |
Lauren Holly | |
Teri Garr | |
Jim Carrey | |
Lin Shaye | |
Jeff Daniels | |
Charles Rocket | |
Karen Duffy | |
Steve Stabler - Producer | |
Mark Irwin - Director of Photography | |
Mary Zophres - Costume Designer | |
Christopher Greenbury - Editor | |
Brad Krevoy - Producer | |
Bennett Yellin - Screenwriter | |
Bobby Farrelly - Screenwriter | |
Sydney J. Bartholomew Jr. - Production Designer | |
Peter Farrelly - Screenwriter | |
Todd Rundgren - Composer | |
Peter Farrelly - Director |


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Relaxation of building rules will be allowed for those releasing land for the widening of the Chakkumkadavu-Payyanakkal road in the city.
This was decided at a meeting held in Thiruvananthapuram recently to discuss the issues related to the development of the road. The meeting was attended by Minister for Panchayats M.K. Muneer, Minister for Public Works V.K. Ebrahim Kunju, and Minister for Urban Development Manjalamkuzhy Ali, it was announced here on Thursday.
Those releasing land for the development of the road would be issued certificates by the Public Works Department indicating the area of the land released. Building rules would be relaxed to enable the land-owners to construct houses on the land that remained in their possession. A meeting of the Chief Engineer (Roads) and the Chief Town Planner would be convened soon by Mr. Ali to formalise the decision to grant relaxation of building rules.
As much as 1.695 acres will have to be made available for the development of the road. At Rs.5 lakh a cent, the land cost will work out to Rs.8.47 crore.
Another Rs.1.25 crore will be needed for the construction of a wall and gate. Administrative sanction has been given for the development of the road at a cost of Rs.3.50 crore. An agreement has also been signed with a contractor after issuing the tender for the construction work.


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« Nightlands releasing new LP, playing shows (dates, stream) | Golden Grrrls sign to Slumberland, releasing debut LP and touring West Coast with Veronica Falls in 2013 »
Posted in music on November 28, 2012
Nick Oliveri w/ Kyuss Lives! at Terminal 5 in 2011 (more by Greg Cristman)
According to a Facebook post on Nick Oliveri's band Mondo Generator's page, Nick, who last year dealt with some legal trouble but is back in Kyuss, "recently recorded his vocals on a new Queens of the Stone Age song." Nick was with QOTSA on their classic albums, Rated R and Songs for the Deaf. Dave Grohl, who recorded drums on Songs for the Deaf, is back on board for this album too and Trent Reznor is also doing some work on it. Here's to hoping they get Mark Lanegan on board for a full SFTD reunion.
Dave Grohl, who was recently added to the 12/12/12 Sandy benefit at MSG, will also by the keynote speaker for SXSW 2013 in Austin.
Trent Reznor, meanwhile, has been keeping busy with his How to destroy angels_ project, who recently released their An omen_ EP and are planning a full length follow up. He just put out a video for the song "Ice Age" off that EP, which was directed by John Hillcoat (The Road, Lawless). You can watch that video below.
How to destroy angels_ - "Ice Age" Official Video
Comments (9)
Completely fuck this guy. People should be ashamed on supporting him. He is a putrid human being. Let's not let some alleged reunion between Homme and Oliveri take away the focus that Oliveri is a known spousal abuser and should be condemned as such, especially when it's obvious he's just as much of a junkie shithead as he ever was based on the SWAT stand off he had a couple of months back.
Also, as a side note, he didn't play on the good Kyuss records, he's nothing compared to Scott Reeder, and he is not the reason some (wrong) people consider Songs for the Deaf the best QotSA album.
Posted by Anonymous | November 28, 2012 8:08 PM
So do you actually KNOW that "Oliveri is a known spousal abuser" ? Or are you just cooking up extraneous details? The fact that the guy had a meltdown with a shotgun is definitely super lame. But the USA love guns. The lame doesn't begin nor end with Oliveri. The whole country is fucking lost in the sand.
Posted by Anonymous | December 5, 2012 12:09 PM
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April 11, 2012 | LXXII, No. 2 | View PDF
The PTA will hold its April general meeting on Thursday, April 12, at 7 p.m. in the Grand Coulee Dam Middle School library.
The group, which advocates for school improvments, will hold its general elections and encourages all community members to attend, said President Aaron Derr.


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This is just great, and sums up so many things - including, most especially, my gratitude. Plus, I just thought y'all might like to understand the lyrics for once. :-)
As you might expect, there's more to this video than meets the eye. More music, and more of a story...
Yeah, I did. I think we should all vote like that [turning out the incumbent party after two or three terms]. Otherwise we're just the slaves of any political party. We should vote for the welfare of the country, not for the welfare of the party.That's a tagline if I've ever heard one...
Wow, a French film - well, short really, but you get the idea - that I like. I'd say "who knew?" But if you've ever seen Brotherhood of the Wolf, you'll know that some French films are good:
This one won a bunch of deserved awards, and even has its own web site.
From Russell Kirk's 1981 essay "The Moral Imagination."
"Every major form of literary art has taken for its deeper themes the norms of human nature. What Eliot calls "the permanent things" - the norms, the standards - have been the concern of the poet ever since the time of Job, or ever since Homer: "the blind man who sees," sang of the wars of the gods with men. Until very recent years, men took it for granted that literature exists to form the normative consciousness - that is, to teach human beings their true nature, their dignity, and their place in the scheme of things. Such was the endeavor of Sophocles and Aristophanes, of Thucydides and Tacitus, of Plato and Cicero, of Hesiod and Vergil, of Dante and Shakespeare, of Dryden and Pope.
The very phrase "humane letters" implies that great literature is meant to teach us what it is to be fully human...."
This phrasing ["You Lie!"] is not a "breach of protocol," as the NYT would have it, but part of another protocol. Kenneth R. Greenberg, scholar of dueling (and baseball, oddly enough; he had some interesting things to say on the intersection of those two things in the post-war American South), noted:Now, another scholar named Greenberg -- I don't know if they are related -- wrote a piece on the Jews of Savannah, Georgia. I believe this is the piece, although you can't see the relevant part if you don't have access to an academic library. If memory serves, it recounts the story of how Jews in Savannah were accepted into the community early compared to the rest of the country, as proved by the fact that they were challenged to duels and fought them; for, as Kenneth Greenberg describes at length, gentlemen dueled only with equals. If they were challenged in the terms of honor, and allowed to fight as honorable men, then they were equals in fact.Only certain kinds of insulting language and behavior led to duels. The central insult that could turn a disagreement into a duel involved a direct or indirect attack on someone's word -- the accusation that a man was a liar. To "give someone the lie," as it was called, had always been of great consequence among men of honor. As one early-seventeenth-century English writer noted, "It is reputed so great a shame to be accounted a lyer, that any other injury is canceled by giving the lie, and he that receiveth it standeth so charged in his honor and reputation, that he cannot disburden himself of that imputation, but by the striking of him that hath given it, or by chalenging him to the combat."
Three breaths before Rep. Wilson shouted out that President Obama was a liar, President Obama had said that "prominent politicians" who spoke to concerns about potential end-of-life issues were spreading "a lie." Every Congressman present understood themselves to be a prominent politician; those who had expressed concerns about that issue, then, stood accused to their faces of lying. Rep. Wilson, of South Carolina, responded in anger and in kind.
It may be hard to understand if you aren't from the South, or a similar culture: but "giving the lie" in this case is the furthest thing from a mark of racial disrespect. It is a mark of accepted equality.
If a Southerner accepts you as an equal, and you call him a liar to his face, you will have to fight him. That is courtesy, not discourtesy: he wouldn't bother to fight you if he didn't respect you. He would snort at you, or strike you, but he would not respond to you in the language of honor.
Of course, these days we do not duel, and the only way such an encounter can terminate is with an apology. One was offered, and accepted -- the wager of battle, such as it is today, has been fulfilled according to the ancient forms. It may look strange to places that have not known such wagers in their lifetimes, but this sort of exchange was once the lifeblood of American politics. The South, as always, sustains.
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I doubted very much that the franchise had anything left in it. Hadn't seen the last few, didn't miss them.
The trailer intrigued me, though, and we had some time to kill. Didn't expect much.
I was wrong. Damned if they might not have re-invented the franchise with this one. Definitely an updated series for its time, might even be one of those weird foreshadowing movies in terms of resonance with outside events. Just not sure how they top it going forward.
I suspect most of you have seen this already. If not, do yourselves a favor. Visit this YouTube page, and watch an unemployed, 47 year old spinster walk on a Britain's equivalent of American Idol... and just blow the effing house down.
Thanks to the Internet, this was the viral equivalent of a tsunami. Follow-on TV appearances have been frequent, she may be about to record a duet with her singing idol Elaine Page (who was impressed), and it seems like she won't have to be looking for a job any time, well, ever again. The only shame in all of this is that she's been singing in her village, recording local charity albums (listen to "Cry Me A River" from 1998), rather than being on stage in London's East End for the last 20 or more years. Where she belongs. The good news is, some of the people in her village think that what you just saw on "Britain's Got Talent" wasn't even her best singing. Um, wow.
It's a great story. I love the fact that she sang a stage tune to do it. And I love it that someone with that level of talent was able to walk on, demonstrate it, and let that trump everything else. She didn't win a sympathy vote. She's just that good, and she'll rise as high as her talent lets her. To me, that's what it's all about.
Incidentally, 2007's winner was a guy named Paul Potts, now a multi-millionaire who's touring the world. He was a 41-year old mobile phone salesman, who remembers being beaten up at school every day until he was 18. That was excellent training for his subsequent dissertation on the problem of evil and suffering in a God-created world - and for his life's ambition, which was to become an opera singer....


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September 28, 2012 Attack on Jewish community in Sweden follows surge of hate crimesMalmo's 600-strong Jewish community has endured attacks ranging from verbal abuse to desecration of a synagogue and a Jewish cemetery in recent months. |
A Jewish community building in Malmö, Sweden was attacked overnight between Thursday and Friday with explosives and bricks. "I was shocked that this happened now," Fred Kahn, president of the Jewish Community in Malmö told the TT news agency. "Jewish institutions in Sweden are under constant threat, but we have not noticed anything out of the ordinary recently." The community building houses a kindergarten, meeting halls and apartments. Nobody was injured in the explosion, which, according to witnesses, could be heard several blocks away. According to local police, witnesses saw two speeding cars leaving the scene of the explosion. The police managed to stop one of the vehicles and arrested two 18-year-old men on suspicion of causing severe damage. The police suspect more people were involved in planning and executing the attack. Read more at haaretz.com. |
JewishJournal.com is produced by TRIBE Media Corp., a non-profit media company whose mission is to inform, connect and enlighten community © Copyright 2015 Tribe Media Corp. |


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When Thea Spyer died in 2009, she left all of her property to Windsor, including the apartment they shared. Because they were married, Spyer's estate normally would have passed to her spouse without any estate tax. But because DOMA prevents recognition of the otherwise valid marriages of same-sex couples, Windsor had to pay more than $363,000 in federal estate taxes.
Some people seem to think "those people" are just whining about this "imaginary" discrimination. Can't get much realer than $363K of extra taxes.
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I hope we get rid of the whole thing soon enough.
Wow. Interesting article.
So may of my friends have had to think about these things, had to put into place plans to circumvent this ridiculous act. :( Time for it to go now.
Adina mama to B 4/06 and E 8/13/12 (on her due date!)
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The Preeclampsia Registry (TPR)
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The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy such as eclampsia or HELLP syndrome, their family members, and women who have not had preeclampsia to serve as controls. Information from participants will be used for medical research to try to understand why preeclampsia occurs, how to predict it better, and to develop experimental clinical trials of new treatments.
Condition |
Preeclampsia Eclampsia HELLP Syndrome Toxemia Hypertensive Disorder of Pregnancy |
Study Type: | Observational [Patient Registry] |
Study Design: | Observational Model: Case Control |
Target Follow-Up Duration: | 20 Years |
Official Title: | The Preeclampsia Registry |
- Self Reported Diagnosis of Preeclampsia and Hypertensive Disorders of Pregnancy Confirmed by Medical Records [ Time Frame: Will be assessed yearly, up to 20 years ] [ Designated as safety issue: No ]
Biospecimen Retention: None Retained
Biospecimens are not currently being collected, however, participants are asked for their permission to be contacted about providing a biospecimen in the future. It is not certain yet what type of biospecimen may be collected.
Estimated Enrollment: | 20000 |
Study Start Date: | July 2013 |
Estimated Study Completion Date: | May 2023 |
Estimated Primary Completion Date: | May 2023 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 13 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Participants who self-report a medical diagnosis of preeclampsia or related hypertensive disorders of pregnancy (HDP), their family members, and women who have never had a diagnosis of preeclampsia (controls) will be invited to participate in this registry. Data will be collected on family members (including children) as reported by the participating individual. Minors who have been affected by preeclampsia, such as teens, will be allowed to participate with consent provided by a parent or guardian as well as assent given by the minor. The registry and informed consent may be completed by an authorized representative on behalf of a woman with a history of preeclampsia if she is physically or mentally disabled or is deceased.
Inclusion Criteria:
- Women who were medically diagnosed with preeclampsia or a related hypertensive disorder of pregnancy (HDP) such as eclampsia or HELLP syndrome.
- Female relatives of affected women
- Women who have never had preeclampsia or hypertensive disorders of pregnancy, but who would like to serve as "controls" in research studies of preeclampsia.
- An authorized representative may complete the questionnaire and provide consent for a woman who had preeclampsia, but has died or is disabled as a result.
Exclusion Criteria:
- Those unable to provide consent
- Prisoners
- Individuals unable to speak English
Please refer to this study by its ClinicalTrials.gov identifier: NCT02020174
Contact: Alina N Brewer, BA | 801-994-4103 | firstname.lastname@example.com | |
Contact: Eleni Z Tsigas, BA | 321-421-6957 |
United States, Florida | |
Preeclampsia Foundation | Recruiting |
Melbourne, Florida, United States, 32940 | |
Contact: Alina N Brewer, BA 801-994-4103 firstname.lastname@example.com | |
Principal Investigator: Eleni Z Tsigas, BA | |
Sub-Investigator: Hilary Gammill, MD | |
Sub-Investigator: James Roberts, MD |
Principal Investigator: | Eleni Z Tsigas, BA | Preeclampsia Foundation |
Additional Information:
No publications provided
Responsible Party: | Preeclampsia Foundation |
ClinicalTrials.gov Identifier: | NCT02020174 History of Changes |
Other Study ID Numbers: | 001 |
Study First Received: | December 10, 2013 |
Last Updated: | November 13, 2014 |
Health Authority: | United States: Institutional Review Board |
Keywords provided by Preeclampsia Foundation:
Preeclampsia Eclampsia HELLP HELLP Syndrome Toxemia Hypertensive Disorder of Pregnancy Registry |
Pregnancy Complication Pregnancy Maternal Death Premature High Blood Pressure Hypertension |
Additional relevant MeSH terms:
Eclampsia HELLP Syndrome Hypertension Pre-Eclampsia Pregnancy Complications |
Toxemia Cardiovascular Diseases Hypertension, Pregnancy-Induced Infection Vascular Diseases |
ClinicalTrials.gov processed this record on April 26, 2015


text:
One of LBC's stations has been hit..the one that transmits the local channels, and they are now transmitting via LBC Europe...LBC is a major Lebanese local and satellite channel...They have also hit Mobile phone networks, which means people are without even phone contact...according to Al-Arabiya.
LBC is now reporting that at around 2:30 Lebanese time Israeli tanks invaded the south.
10 Tanks
Is this part of the preparation for a ground offensive..start taking out the local stations, leave everyone in the dark..without news and without mobile phone service?
LBC is showing footage of the artillery fire in the southern village of Maroun il-Ras.
It is 2pm GMT now.
"It was, our journalists told us, to be the greatest evacuation since Dunkirk. There it was again, the Second World War. And it was another cruel lie which the Lebanese spotted at once. For these mighty craft had not arrived to save Lebanon, to protect a nation now being destroyed by America's ally, Israel, Lebanon whose newly flourishing democracy was hailed by our leaders last year as a rose amid the dictatorships of the Arab world. No, they were creeping through the dawn after asking Israel's permission to help their citizens to flee. These great warships had been sent here by Western leaders (Jacques Chirac excepted) too craven, too gutless, too immoral, to utter a single word of compassion for Lebanon's suffering."
Israel told the Lebanese in the South to leave, and is planning to invade the south , and reports coming in say that they have already captured locations in South Lebanon...
They will probably blast it to even tinier smithereens.
BBC Photo
Thanks for the 'humanitarian' warning, it's great when you tell people to run for their lives before you bomb their homes, their schools, their workplaces and their towns and their memories and everything they own... Also, it's pretty great to do that after you have already bombed all the roads, bridges and exits out of the area.
The Lebanese are increasingly terrified that once the foreigners have left the country there will be nothing to restrain Israel from going all out and turning Lebanon to dust and ashes..
A British woman being evacuated yesterday said that everyone she knows thinks that there will be a bloodbath once the American and European citizens have left.
Israel calls up 3,000 reservists to prepare for ground invasion
Israeli troops mass on Lebanon border
U.S. Speeds Up Bomb Delivery for the Israelis
Saturday, July 22, 2006
at 2:50 PM
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text:
While the merits of theory-driven and realist evaluation have been widely discussed in journals on evaluation, there is relatively little documented experience with theory-driven inquiry in the domain of health services and health systems. As an illustration, some interesting papers are briefly discussed below.
Birckmayer and Weiss (2000) present a review of 6 health promotion studies based on theory driven evaluation.
Mercier et al. (2000) carried out a theory-driven evaluation of drop-in activities at a YMCA Youth Center and present a clear methodology to develop and test the programme theory
Grocott et al. (2002) is an example of how TDE was applied to patient care, in this case the palliative management of malignant wounds.
Rodriguez, E. & Mead, J. (1997) describe a retrospective theory driven program evaluation to assess the complex processes and dynamics underlying the program and which influence its outcomes. They show how TDE examines the black box of processes and mechanisms and provides insights in what went wrong.
Judge and Bauld (2001) and Sullivan et al. (2002) present findings of the Theory of Change approach in an assessment of Health Action Zones in England.
MacKenzie and Blamey (2005) discuss the assessment of the Scottish Health Demonstration projects in child health and heart disease prevention
Evans and Killoran (2000) present the evaluation of a Health Education Authority's Integrated Purchasing Programme and specifically of demonstration projects testing partnerships to tackle health inequalities.
Byng et al. (2005) and Byng et al. (2008) applied realist evaluation principles to evaluate a mental health programme in the NHS.
Leone (2008) presents an overview of how a MRT for an intervention can be derived from an analysis of the programme, how this MRT is translated into research questions and how analysis is done.
Ogrinc and Batalden (2009) develop a practical evaluation framework to assess teaching programmes on improvement of care on the basis of realist evaluation principles.
Greenhalgh et al. (2009) apply realist evaluation in the assessment of the Modernisation Initiative, which aimed at whole-scale transformation in stroke, kidney and sexual health services in London.
Pommier et al. (2010) present a research protocol for evaluation of health promotion in schools.
Blaise and colleagues explain how realist evaluation compares with other methods used in health promotion research. This is one of the few texts in French on realist evaluation.
There are even fewer publications of TD inquiry in health systems research in low and middle-income countries:
Blaise and Kegels (2004) focus on quality management, comparing European with African sites.
Connelly et al. (2007) present a realist synthesis of controlled trials of childhood obesity prevention programmes.
On 22 and 23 November 2010, the Unit of Health Care Management, Department of Public Health (ITM), organised an international expert meeting on theory-driven evaluation.
About 15 researchers presented research and evaluations and discussed the methodological challenges of realist evaluation, theory-driven evaluation and realist synthesis in health systems research.
In total 30 researchers, policymakers and programme managers attended the workshop.
This theory-driven inquiry website is developed by the Health Care Management Unit of the Department of Public Health, Institute of Tropical Medicine, Antwerp and the Development Policy & Practice Unit of the Royal Tropical Institute, Amsterdam. We collaborate on the development and implementation of theory-driven inquiry in health systems research, and aim at stimulating a better understanding of the advantages of this approach among both researchers and policymakers. To this end, we are engaged in a number of research and evaluation studies that use TD inquiry principles.
TD inquiry project evaluations
Défi Jeunes
TD inquiry research projects
PhD Bruno Marchal
PhD Pierre Blaise
The cluster Research methodology for complexity in healthcare
Bruno Marchal - personal page
Guy Kegels - personal page
Tom Hoerée
Josefien Van Olmen - personal page
Sara Van Belle
TD inquiry project evaluations
Realist evaluation of ASHA program in a district (India)
TD inquiry research projects
Realist inquiry in capacity building
PhD Marjolein Dieleman
Research and evaluation methodology
Marjolein Dieleman
Barend Gerretsen
Sumit Kane
Prisca Zwanikken


text:
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www.cosmopolis.ch No. 12, December 2000 current edition & archives Art Film Music History Politics Archives Links For Advertisers Feedback German edition Travel Copyright 2000 www.cosmopolis.ch Louis Gerber All rights reserved.
Columbia Chronologies of Asian History and Culture Indonesian history/a history of Indonesia as an example Hardcover, 751 p., Columbia University Press, August 2000, ed. John S. Bowman. Get it from Amazon.com, Amazon.co.uk, Amazon.co.uk or Amazon.de
For more articles on history: History.
The Web Cosmopolis.ch


text:
C.B. Gurumurthy, Ph.D. Mouse Genome Engineering Core Director 402-559-3338 Email
All fields are required.
Lab Information
Principal Investigator:
Contact Person:
Person/Dept Billing should be directed:
Cost/Center Number:
IACUC approval number and title to Transfer Animals from:
Mouse Line to be Cryopreserved:
Strain of Mice to be Cryopreserved:
Genotype: Homozygote Heterozygote
Can MGECF freeze this line as heterozygous? Yes No
Number of Stud Males: Age: Months or weeks?
If Mice must be maintained only as Homozygous: Number Females Age:
Present location of animals: Building: Room Number:
Provide Health Status REPORT
What is known about the reproductive status of these mice?
Average age if first litter: Average litter size:
How many litters are expected from each female?


text:
Path to document: Homepage:
- Archive
Hereafter events organized by the Czech National support structure or Managing Authority are displayed in yellow. Other events are displayed in blue.
Information about international events organized by other entities may be found on web pages of the European Commission.
Click here to access the European Equal page.
CLOSING CONFERENCE CIP EQUAL (Innovation fair for the open labour market)"
Where: PragueWhen: 22 - 23 April 2008
From Theory to Practice - Stories of Success (programme)
Where: PragueWhen: 19th November 2007, 10 a.m. to 16.30 p.m.
From Theory to Practice - Stories of Success
Where: PragueWhen: 19th November 2007, 10 a.m. to 16.30 p.m.
Reception event LISABON: Connecting Policy with Practice
Where: West Midlands in Europe, 22-28 Avenue d'Auderghem, 1040 BrusselsWhen: 7th November, 9:30 a.m. - 2:00 p.m.
Transnational conference of the partnership REAL - Ready for European Adult Learning
Where: Czech Republic, Bohemian Paradise – Sedmihorky, Tourist Hotel Lázně SedmihorkyWhen: 1st - 2nd June 2007
Updated: 11.4.2008 | Author: Equalcr


text:
$34.95 |
SKU: GC-iS-BLK Order by 4PM MST and it ships today!Learn more |
Treat your iPhone 5/5s to Scratch-resistant, lightweight protection that is easy to apply, lasts longer, never peels, and does not diminish your phone's good looks. Includes:- Tempered Glass screen protector - Ultra-thin snap case - Microfiber cleaning cloth - 2 adhesive home button covers.
iPhone 5s Sep 2013
iPhone 5 Sep 2012


text:
dc.contributor.author | Tun, Thet Paw | |
dc.date.accessioned | 2010-07-02T13:12:54Z | |
dc.date.available | 2010-07-02T13:12:54Z | |
dc.date.issued | 2010-07-02T13:12:54Z | |
dc.identifier.uri | http://hdl.handle.net/10539/8261 | |
dc.description.abstract | In 2008, the World Health Organisation's life expectancy for an average South African was forty eight years of age. South Africa therefore has a drastic need to improve its health care facilities with regards to ease of access, quality of service and the level of care in order to ensure and improve the health of its citizens. Currently, the Department of Health is implementing a change from a traditionally curative based health care system to a preventative and promotive based system. This thesis will indicate how a preventative and promotive health system can complement the curative system. It will as a result develop a new type of building and spaces to accommodate the new health care system's needs: A Preventative Community Health Centre (CHC). The two main types of diseases that are critically effecting South Africans and attributing to high mortality rates are HIV/AIDS and Non- Communicable Diseases (non- contagious disease i.e. heart diseases and stroke). These diseases result from unhealthy lifestyles and behaviour and there is as yet no known cure for them other than preventive care. The centre in this thesis aims to educate South African citizens in a suburban context of a township on healthy behaviour and healthy lifestyles in healthy spaces. However, the success of a CHC depends on the participation of the community in which it is situated. Therefore, to encourage the frequent use of the building, the health care facilities must be de-stigmatised. The project is located between a curative institution and a shopping mall. This therefore creates a new urban context. The major focal points of this project are- accessibility, re-design of waiting areas and diversification of health care facility program. | en_US |
dc.language.iso | en | en_US |
dc.title | Healthy space/healthy lifestyle: the design of a preventative community health centre | en_US |
dc.type | Thesis | en_US |


text:
Learn more about Crucial Ballistix 2GB (2 x 1GB) PC2-6400 800MHz 240-pin DDR2 Memory:
The Ballistix line is specifically built for performance enthusiasts who want to push the performance envelope without worrying about data loss or corruption, mysterious intermittent errors and display problems, or worse the dreaded BSOD! The Ballistix line of high-performance memory modules features advanced speed grades, low latencies, and integrated aluminum heat spreaders. |
NVIDIA SLI-Ready | |
Capacity: 2GB (2x 1GB) | |
Type: 240-pin DDR2 | |
Speed: PC2-6400 800Mhz | |
Latency: 4-4-4-12 | |
Signal Processing: UNBUFFERED | |
Error Checking: NON-ECC | |
Voltage: 2.2V | |
Configuration: 128MB x 64 | |
Warranty: Lifetime Limited | |
Manufacturer Part Number: BL2KIT12864AA804 | |
www.crucial.com | |
Tech Specs
Product Type | RAM Module | |
Brand Name | Crucial | |
Manufacturer Part Number | 112438 | |
Product Name | 2GB DDR2 SDRAM Memory Module | |
Manufacturer Website Address | www.crucial.com | |
Manufacturer | Crucial Technology | |
Form Factor | 240-pin | |
Error Checking | Non-ECC | |
Memory Technology | DDR2 SDRAM | |
Number of Modules | 2 x 1 GB | |
Memory Speed | 800 MHz | |
Memory Standard | DDR2-800/PC2-6400 | |
Signal Processing | Unbuffered | |
Memory Size | 2 GB | |
Standard Warranty | Lifetime Limited |
Customer Reviews of Crucial Ballistix 2GB (2 x 1GB) PC2-6400 800MHz 240-pin DDR2 Memory
Most Recent Reviews
Excellent memory sticks
3/28/2009Now significantly cheaper than when I bought them, but a good buy at the time. Have worked flawlessly.
bad QC
12/30/2008yea the ram doesnt cost much, but batch after batch is defective/fails after very little amount of use. had for about 3 months before both sticks went bad. tons of reviews say the same thing, especially after they made the ram single sided instead of double sided like it originally was
7/15/2008I bought for my Dell vostro 200 desktop. Perfect!
Good n Cheap..,
7/7/2008This is not the fastest but for 2GB's sub $20 it is great... Make sure you adjust the timing on your Mobo to get max speed.
Works Great
7/7/2008Installed on a Dell XPS 420 with an Intel Quad Core 6600 processor, running at 2.4 gig. Installation was easy as pie and it works fine. Noticable improvement over previous memory configuration. Has been installed for over two weeks without a single issue. Well worth the price of admission. Used free shipping option and it got here in two days.
Cheap and perfect
7/2/2008I have this memory for about 2 weeks. Installation was easy, and my new rig recognized it as dual 800 on first POST. Runs stable under 1.98 volt, not so hot. Did not try to overclock them yet. Inexpensive, good looking, stable - what else? Submitted rebate but did not see it yet to be accepted. Prices on memory are droping and I hope to buy 1066 8GB pair for $50 in 2 years to install new MS Windows OS currently under development.
Can not beat Crucial w/rebate
6/29/2008I bought this RAM to upgrade my mothers old Dell 4700, and has worked out great. You can really tell the difference between the 512 original memory, and this 4GB's. Where else can you get 4 gigs of good RAM for $50, after the rebates! Go for it. JP
jptt63 from Waco, Texas
I got a bargain
6/27/2008I got this kit for $19.99 after rebate. You can't beat that with a stick. It's 2 gigs, it works, and it's played nice with my pre-existing 4 gigs of mushkin, so it was a steal for me.
Great price, great product
6/27/2008I bought four sticks and have used them for about a week. I jumped from 1G of RAM to 4G. So far, well worth the investment.
6/27/2008worked fine when i put it in, so i removed upc for rebate, and the next day my computer started crashing.i have sent the ram back to crucial for replacement, since i can not return the memory to buy.com after removing the upc. this of course is not buy.com's fault.i have bought many items from them, and thier service has been great.not sure how long i will be without the memory, but crucial did not hassle me, and it's lifetime warranty memory.i was not even trying to overclock, or even run at stock, just trying to match my other 2 gigs of stock memory at 5-5-5 15 1.8v. i tried bumping up to 2v, but it didnt help.cpuid shows that its rated to run 5-5-5 15 at 1.8v btw.
OCZ Ram
6/26/2008Received Fast..Waiting for rebate..
Good RAM and cheap
6/25/2008The RAM works fine on my DELL Inspiron, but could not run at 800 MHz when mixed with pre-installed Samsung (800MHZ) chips. However, it runs at 800 MHz without the Samsung chips. The free shipping was too slow, it took almost two full weeks to receive.
Great memory for a great price
6/25/2008Used this kit in a new system I built. It was easy to install and works great.
Ryan from Minneapolis, MN
Cheap Price, Good Value
6/24/2008Ordered 2 of these, one for my home PC and one for my work PC. One uses XP, other Vista, both work fantastic. Installed both in under 1 min. Windows loading time is much faster, applications load faster and run smoother. Can't complain yet, and the price is ridiculously cheap. Just waiting for rebates now (fingers crossed)
Kenny from Concord, CA
So far, so excellent...
6/22/2008I bought the 2gb kit and it obviously installs easily. Before I bought this memory, I read a lot of semi-negative and some plain old negative reviews on the memory. I am here to report that this memory is stable and error free, so far. I will check back in a month with further results after a little overclocking action.
Carl P. from Martin, TN
4 gig works
6/22/2008Wanted to update my last review from June 18, 2008. I updated my Vista PC with SP1 and magically, the 4th memory stick works now. Thanks MSFT for the fix, I think.....
Mike from Rochester, NY
Memory ROCKS!
6/22/2008This is good stuff! I purchased an Acer tower, it came with 1G RAM, Windows Vista Home Edt...slower than molasses...added the 2G of Crucial RAM, not it runs like a scalded dog! Best thing I could have done.
Sterling from North Carolina
Great ram, great site
6/19/2008This 2gb kit was easy to install and after configuring timings in the bios, ran at the advertised speeds. No problems whatsoever. Thanks to Buy.com for the quick delivery too.
Kris from Brooklyn, NY
Got a Dead one
6/18/2008I got all happy when I was building a new rig and installing 4 of these sticks. When to run it for the first time and I got me a blue screen. Fooled around a bit and finally found out it was one of the sticks that was causing it. Even though I am only using three sticks, my rig is awesome. Would have gotten a 5.9 in Vista but due to lower memory, got a 4.6......
Mike from Rochester, NY
Good memory but can corrupt
6/15/2008Great 2G memory for a really good price especially after rebate. I bought these Crucial Ballistix 2GB kit from other online store about 2 months ago. The memory was running fine in my AMD x64 5600 gaming computer for about 1.5 months and started getting BOD on both my Vista Ultimate 32bit and Windows XP 64-bit. (I have dual boot since I got 32-bit Vista Ultimate for free from attending a MS event so I had to try it.) I bought the exact same memory 2 weeks ago from Buy.com to replace the defective ones. The problem went away. I contacted Crucial and they are issuing an RMA. Hopefully they'll send replacements for me and I'll have 4G in my system.
Patrick from Madison, WI
Upgrade your HP Pavilion Slimline
6/2/2008I bought an HP Pavilion Slimline s3100n here on buy.com a few months back and I love it, with the exception of a few performance disappointments on graphics-intensive apps (i.e., games). I bought this Ballistix memory set to upgrade from the stock 1 gig (2 x 512 meg) to the 2 gig max config. Even though the memory speed is rated higher than the computer bus can take full advantage of, it works perfectly in the s3100n and it made a big improvement in performance. Specifically the Windows Experience Index subscore for memory ops per second went from 3.9 clear up to 5.3 (max is 5.9). The subscore for desktop performance for Aero (previously the limiting factor) went from 2.5 to 3.0. All this at an amazingly low price. I really don't think I've ever been happier about the value of any purchase I've ever made.
Tom Webster from Minneapolis, MN
fast memory
5/26/2008i get a 5.9 on vista stock.
Great Memory at a Great Price
5/11/2008Works wonderful on my dual core AMD processor. Takes about six weeks to get the rebate from Crucial. Make sure you use the correct date range for the rebate form on the Buy.com web site.
David from Miramar, FL
Great working memory but shipping is slow
4/28/2008I bought this memory and it took almost two weeks to get to me. when I received the memory the rebate was conveniently expired.
mike from chicago, illinois
Great Memory for a Great Price
4/23/2008These two memory chips work great with my ASUS motherboard and my AMD processor. I highly recommend this product. Please make sure that you ave the right rebate form when you submit it; buy.com seems to post a new rebate form every two weeks.
On time shipping and great item
4/14/2008Finally Windows Vista works fast. Best upgrade I've made.
Robert from San Francisco
Works as expected, plus a little more
4/5/2008I've been running with these parts for about a month now (non-stop). They are solidly built and the heat-sinks seem securely attached. I installed them in a GIGABYTE GA-MA74GM-S2H motherboard with a AMD64 X2 5200+ 2.7GHz. I configured them for 2.1v and 4-4-4-12 timing over-clocked to 840GHz. I run intense Bionic SW in the background which really exercises them and have also run UT and Guild Wars w/o incident. I would recommend them to anyone.
Randy from Chicago, IL
High quality at a great price
4/2/2008I purchased this memory to upgrade a Dell Inspiron 530. The memory works flawlessly, and with the rebate it was very inexpensive.
Works as expected... plus a little.
3/27/2008I have these parts running on the GIGABYTE GA-MA74GM-S2H with a Athlon 64 X2 5200+ Brisbane 2.7GHz over-clocked to 2.84Ghz and it performs w/o a hiccup. I have think the BIOS has it running at 5-5-5-15 instead of 4-4-4-12 (the motherboard is not giving me the options to change it) but the memory bus speed is 840MHz because it's over-clocked. I have it running at 2.1v. With the rebate, it's good bang-for-the-buck.
Randy from Chicago
Great memory
3/26/2008I ended up paying about $34 for 2gb. What a great deal. Very stable memory. Unbeatable deal....
Great price - assuming rebate comes
3/24/2008Very happy with this memory. Popped it into my motherboard and it worked great. I had some concern since the memory says it is 2.2V, and my motherboard supposedly can't handle above 2V memory, but it worked fine. Just waiting for my rebate check now.....
Mike from Viriginia
great ram
3/12/2008excellent ram, works great on my dell desktop
Works well... period.
3/10/2008Worked great in my new motherboard. Worth the few extra $$ compared to cheap ram.
Great Name Great Memory
3/5/2008This ram was amazing. Posted right out of the box. I love the tight speeds on this peticular line. This is the ram you need!
Drock from Michigan
Crucial question
3/1/2008(*Although this is the "review" section, I am posting a question 'cause I can't seem to find the info elsewhere**I'll check back soon to see if anyone has commented*) I am wanting to purchase the Crucial Ballistix 2GB kit (2x 1gb) PC2-6400 DDR2-800Mhz; 2.2V; CL 4-4-4-12. I will be installing it into a Dell Vostro 200 mini; Intel e4550; pre-installed with 1gb (2x 512mb) PC2-5300 DDR2-677Mhz...unknown CL, and I'm certain they run @ 1.8V, although I may be wrong. I already know that if mixed, the performance defaults to the slower module's speed, but I'm questioning the compatibility because of the (listed) voltage difference. Are these two particular types of memory compatible? Any insight to this matter will be greatly appreciated!
Bad Ram!!!!
2/19/2008I bought two bundles of this and received to bad sticks....and what is left of that my computer only recognizes about 3/4 of that....i guess if you get good sticks then it would be a great value.
Greg Lewis from Belleville, IL
Stable, if you get good sticks
2/14/2008One of the first pair of sticks I bought was bad, so had to RMA. RMA was easy, though a bit slow. I was worried about making the rebate deadline in time. Second pair arrived and are workin flawlessly. I also have a pair of Patriot sticks with the same timing and they play well together. Havn't tried overclocking yet, but will try soon.
1/15/2008Speedy upgrade
Solid memory
12/17/2007used for my first build and couldn't be happier. both sticks were picked up immediately and haven;t even needed to change voltage with my OC'ing (OC'd by 27%). Rebate received with no issue
Blink1ce from Rockville, MD
WOW, for this deal- no brainer!
12/16/2007Lets face it, for the pc2-6400 sticks running at the lower timings of 4-4-4-12 this was a super deal. There was no problems and I even overclocked them just a bit. They run fast and stable while looking nice too (if that matters). Great ram at a great price!
Luke from Dixon, IL
Can't beat this deal.
12/10/2007And Crucial is top notch!
12/9/2007Great memory, not one issue with it. If your looking for some good memory, this is the momory for you, Buy.com is the place to get it. Received my memory in 2 days, now back to gamming.
haywardw from San Antonio Tx
Make Sure you know it works first
12/7/2007I bought this memory to use in Dell XPS 420. I purchased the Dell with 2GB of 800MHZ memory on board and this would bring me to a total of 4GB of 800MHZ Memory. Unfortunately, Dell didn't document that their OEM memory runs at 1.8volts. This memory runs at 2.2volts. As a result of the differing voltages adding this kit to the machine made all 4GB run at 667MHZ. Of course it took some time to deal with Dell to discover this undocumented issue and as a result I have exceeded the time allowed to return this memory.
rbuetow from North Tustin, CA
Good Memory
12/5/2007I have been running my system with this memory for the past few weeks and have had no problems whatsoever.
Terrific value
12/3/2007I got 4GB (2 of the 2x1GB packages) for $119.90, no rebate needed, free shipping. Put these in a HP m9060n which came with 3GB of PC2-5300 (which I stuck in my older system). Very stable so far, and no glitches with Blu-Ray and HD DVD playback.
Beepclick from Minneapolis MN
12/3/2007I had to upgrade my motherboard, and this RAM is very fast. It handles anything I want to do, but I don't play games. Maybe I should start?
Jack from Birmingham, AL
Works Great, Fine Product
11/30/2007Easy to install, memory has great reputation, works just fine. I installed it an upgraded to Vista. If Vista worked half as well as this memory (take it out of the box and it *actually* works) then Microsoft would be king.
Anthony Bollinger from Vermont
Good Stuff!!
11/29/2007Put it in an it was a notisable improvment - when I got my computer built last year these where almost $300.00 EACH! I thought the price would drop and it is now cheaper than the RAM I got for my 386 back in the 1980s' and that was megebytes not Gigabytes!!! 1 more happy camper!
Kevin from Colorado Springs, CO
Great memory--Great deal
11/29/2007I actually feel like I took advantage of Buy.com and Crucial. Fast, flawless memory and a fantastic deal. What's not to like?
Ray from Spring Hill, Florida
Great Ram
11/27/2007Great ram for the price. No problems installing went right in. Would highly recommend.


text:
Woman flown to hospital after serious crash
Accident happened Sunday night in Belmont
Published 8:07 AM EST Dec 24, 2012
Belmont police said a 22-year-old woman was flown to Dartmouth-Hitchcock Medical Center Sunday night after a serious crash.
The accident happened at about 10:04 p.m. on Route 3, in front of the Belknap Mall.
Police said the woman was driving southbound when her car went off the road and slammed into a tree. Rescue crews had to extract the woman from the wreckage.
A section of Route 3 was shut down for about two hours while police investigated the accident.
The identity of the victim has not been released and there is no word on her condition.
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