text:
My baby is rapidly approaching the walking stage. She is almost 7 months old now and I know soon will be standing up and trying to walk. So, is it better for her to walk barefoot or with shoes? I've heard mixed feelings on this. I know when my brothers and I were growing up, we wore those hard booties to make sure our feet were straight. I'm not even sure you can find those anymore. But, I've been reading a lot of articles saying that it's best for babies to walk barefoot. But what about cold hard floors and won't that hurt my little girl's feet?
Introducing, Robeez. Apparently, these shoes have soft soles and are flexible, yet supportive. They are supposed to be just as good as walking barefoot, but provide protection. They're kinda cute too aren't they? Check them out!
Shoes or no shoes…
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The Belkin N600 was a breeze to set up and it was reliable throughout our test period. It was a little sluggish in our wireless transfer tests, and its Web interface is slow, but it was fine for high-def video streaming and the chances are you won't have to use its Web interface often anyway. It's well worth considering for a simple home network.
Belkin has given its N600 DB Wireless N+ Router (F9K1102v1) a new look that's glossy and perhaps a little more suited to lounge rooms than the PlayMax models before it. It has a slim profile that flares towards the rear and it doesn't have an overabundance of bright LEDs — just one main blue LED indicator. It's a wireless router that offers simultaneous dual-band operation, good range and hard drive sharing features for a very reasonable price, but it does have some downsides. Mainly, it has a slow Web interface and its wireless transfer speeds didn't hit all the speed marks we were expecting. One thing we can say though: it was reliable.
We used this router for two weeks in our test environment and it proved to be a reliable performer. It didn't unexpectedly restart and our iiNet Internet connection never dropped out. As the N600 DB Wireless N+ doesn't have a built-in modem, we connected the little Billion BiPAC 5200S RD ADSL2+ modem for our tests. It was a match-up that worked well for us and setting it all up was easy.
You can set up this Belkin either by attaching it to you computer with an Ethernet cable (the router has a 100Mbps switch), or by connecting to it wirelessly. You don't have to worry about the router being exposed to intruders when you first switch it on because it comes with a pre-configured SSID (wireless network name) and has WPA/WPA2 password encryption enabled. These details are printed on a card that's supplied with the router and they make the set up procedure a breeze if you're a laptop user.
If you've never set up a wireless router before, you can use the supplied installation CD-ROM to get started. This has a wizard that shows you all the physical connections that need to be made, and it then asks you to enter the wireless network credentials from the printed card. Assuming you've made all the correct physical connections, it then asks you to enter your ISP username and password and connects you to the Internet. This process takes a few minutes (which felt like eternity to this reviewer) but the reason for the long wait is that Belkin installs management software for the router on your computer in the background. It's called Belkin Router Monitor.
Once the set up has completed, you can use Belkin Router Monitor to log in to the router's Web interface and perform advanced functions (such as port forwarding) or to personalise the SSID and password encryption. The Web interface itself has the same layout as previous Belkin routers we've tested, including the PlayMax F7D4401au. (Incidentally, we'll take the time here to mention that since Belkin released an updated firmware for the F7D4401au, it has addressed the reliability issues we saw in our initial review. We have been using it non-stop for weeks and it has been fast and reliable.) However, the N600's is a slow interface in which a change to almost any setting (including the SSID and password) can take at least 40sec to be implemented. Furthermore, the SSID and security settings are not on the same page, which is inconvenient. You can change the 2.4GHz and 5GHz settings from the same page though.
In our speed tests, the Belkin N600 wasn't overly impressive. In our 2m tests, the router recorded a file transfer rate of 6.97 megabytes per second (MBps) using the 2.4GHz network and 7.07MBps using the 5GHz network. We expected results closer to 9MBps considering what Netgear's N600 (no relation to the Belkin) and Linksys' E3000 recorded from that distance. The Belkin's performance was reliable though. From 10m away, it recorded similar results to the 2m tests: 6.65MBps using the 2.4GHz network and 6.04MBps using the 5GHz network. These are still slower results than we were expecting but we were nevertheless able to use either of these networks for effective video streaming.
In our test environment, we were able to stream high-definition video smoothly up to 15m away using the 5GHz network. The 2.4GHz network also proved to be effective at video streaming from this distance, although it wasn't as reliable as the 5GHz network. We tested in an environment surrounded by many other 2.4GHz networks. A usable signal for Web browsing was achieved up to around 37m away, which is similar to what we have been able to accomplish with other routers. These results will vary depending on your own environment, but compared to other routers we have seen, the Belkin puts up a decent showing as far as distance is concerned.
The Belkin N600 has a built-in powered USB port that can be used to share an external hard drive across your network. This drive can be accessed simply by browsing your network and it will appear just like any other network drive. It's not as extensive as the ReadySHARE feature in the Netgear N600, and there are no management features for the USB port in the Web interface (only in Belkin's Router Monitor software).
You can copy files to and from an attached disk, it can be accessed simultaneously by multiple users and its performance is good enough to allow high-definition video files to stream off it. Devices on your network that support DLNA will be able to see the drive and stream any media files that are on it. If you use Belkin's Router Monitor software, you can also schedule back ups to be performed to your attached USB disk.
For what you pay (without having to shop around for a deal), the Belkin N600 is quite good value, but we can't help but feel that it should have a Gigabit Ethernet switch; after all, the Linksys E3000 can be purchased for around the same price or lower if you shop around and that model includes Gigabit. We also wish the Belkin performed faster in our wireless transfer tests, and that its Web interface was quicker. Nevertheless, we are very pleased with its reliability during our two-week test period and its simultaneous dual-band operation worked well. Parents might be interested in knowing that it also includes a URL keyword filter.
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First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.

subset: commoncrawl


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Hear the untold stories of enslaved people and learn about historical and contemporary slavery.
A beautiful building housing one of the UK's finest collections of fine and decorative art.
Uncover objects from the Titanic, find out about life at sea and learn about the port of Liverpool.
This new museum tells the story of Liverpool with diverse exhibits housed in a stunning building.
Explore a Victorian merchant's house with its period furniture and beautiful paintings.
Beautiful paintings, sculpture and decorative art from the 13th century to the present day.
Discover treasures from around the world, explore outer space and meet live creatures!
Also in this section…?
Family Membership is a great way for the whole family to enjoy a more personal experience in our venues whilst introducing your children to our vast collections in an educational and fun way! For just £40 families of up to 2 adults and 5 children will enjoy a full 12 months of membership. In return you will receive:


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Andrew Hurwitz | |
Judge of the United States Court of Appeals for the Ninth Circuit | |
Incumbent | |
Assumed office June 27, 2012 |
Appointed by | Barack Obama |
Preceded by | Mary Schroeder |
Vice Chief Justice of the Supreme Court of Arizona | |
In office July 1, 2009 – June 27, 2012 |
Preceded by | Rebecca Berch |
Succeeded by | Scott Bales |
Justice of the Supreme Court of Arizona | |
In office March 17, 2003 – June 27, 2012 |
Appointed by | Janet Napolitano |
Preceded by | Stanley Feldman |
Succeeded by | Ann Timmer |
Personal details | |
Born | October 1947 (age 67) New York City, New York, U.S. |
Political party | Democratic |
Spouse(s) | Sally Hurwitz |
Alma mater | Princeton University Yale Law School |
Andrew David "Andy" Hurwitz (born October 1947) is a United States Circuit Judge for the United States Court of Appeals for the Ninth Circuit.
Judge Hurwitz graduated cum laude and Phi Beta Kappa from Princeton University in 1968 with an A.B. in Public and International Affairs.[1] While at Princeton he earned the ignomious distinction of participating in the longest winless streak of the men's soccer team, as part of the 0-7-3 squad in 1966.[2]
He earned his J.D. from Yale Law School in 1972, where he served as a member of the Board of Editors[3] and the Note and Comment Editor[4] of the Yale Law Journal.[1]
After law school, he clerked for Judge Jon O. Newman of the United States District Court for the District of Connecticut.[5] and for Judge J. Joseph Smith of the United States Court of Appeals for the Second Circuit.[1]
From 1973 to 1974, he clerked for Associate Justice Potter Stewart of the United States Supreme Court.[6]
Hurwitz practiced law in Phoenix for nearly 30 years before becoming a judge. He was a partner at Osborn Maledon from 1995–2003, and an associate and partner at the predecessor firm Meyer Hendricks Victor Osborn & Maledon from 1974 to 1980 and from 1983 to 1995.[1] His practice included commercial litigation, administrative law, and government affairs, but he was best known as one of the most skilled appellate specialists in Arizona.[citation needed]
His most notable case as an appellate attorney came in 2002, when he successfully argued Ring v. Arizona before the United States Supreme Court.[7] Representing Timothy Ring and several other death row inmates, he argued that in murder cases the Sixth Amendment requires juries, rather than judges, to make factual determinations that aggravating circumstances exist that qualify defendants for the death penalty. The Supreme Court agreed in a 7-2 decision that dramatically altered capital sentencing in Arizona and a number of other states.
From 1980 to 1983, Hurwitz took a break from the practice of law to serve as chief of staff to Governor Bruce Babbitt.[1] Among the projects he oversaw for Governor Babbitt was the creation of the Arizona Health Care Cost Containment System (AHCCCS), an innovative program to control Medicaid costs.[8] His experience in the governor's office led then-Secretary of State Rose Mofford to tap him to lead her transition team during the 1988 impeachment of Governor Evan Mecham.[9] When Mofford became governor after Mecham's removal from office, Hurwitz became her chief of staff.[10] He later served as co-chair of the transition team for Governor Janet Napolitano.[1]
In addition to his work for three Arizona governors, Hurwitz has held a variety of other public service positions. He served as a member of the Arizona Board of Regents overseeing the state's public university system from 1988 to 1996, including a term as president of the Board of Regents from 1992 to 1993.[1][11] He chaired two City of Phoenix committees focused on neighborhood improvement and street environment from 1986 to 1990.[1] He also served on the boards of directors of the Arizona Center for Law in the Public Interest (1986–1988) and the Children's Action Alliance (1999–2003). In addition, he has been an adjunct and visiting professor at the Sandra Day O'Connor College of Law at Arizona State University since 1977, teaching Ethics, Supreme Court Litigation, Legislative Process, Civil Procedure, and Federal Courts, among other classes.[1][1]
Hurwitz was appointed to the Arizona Supreme Court in 2003 by Governor Janet Napolitano, replacing former Chief Justice Stanley G. Feldman.[12] In the 2006 election, he received another six-year term, with more than 77% of Arizona voters casting ballots in favor of his retention in office.[13]
In March 2009, he was elected to serve a five-year term as Vice Chief Justice when Justice Rebecca White Berch was elected Chief Justice.[14]
Notable opinions he authored include:
On November 2, 2011, President Obama nominated Hurwitz to be a United States Appeals Court judge for the Ninth Circuit.[15] On January 26, 2012, he received a hearing before the Senate Judiciary Committee and on March 1, 2012, his nomination was reported to the floor of the Senate by a vote of 13 ayes to 5 nays.[16] All ten Democratic Senators voted aye along with Republican Senators Tom Coburn, Lindsey Graham and Jon Kyl, while Republican Senators John Cornyn, Chuck Grassley, Orrin Hatch, Mike Lee and Jeff Sessions voted no.[17] On June 7, 2012, Senate Majority Leader Harry Reid filed for cloture on Hurwitz's nomination. On June 11, 2012, cloture was invoked by a vote of 60 ayes to 31 nays.[18] On June 12, 2012, he was confirmed by voice vote and received his commission on June 27, 2012.[18][19]
In addition to his judicial duties, Judge Hurwitz served as a member of the Advisory Committee on the Federal Rules of Evidence. He was appointed to the advisory committee by Chief Justice William H. Rehnquist in 2004, and reappointed by Chief Justice John Roberts in 2007.[14] He is a member of the American Law Institute (since 2002) and a master of the Horace Rumpole Inn of Court (since 1997).[14]
This section is empty. You can help by adding to it. (January 2015) |
He is a native of Boonton, New Jersey, having moved there with his family at the age of 3[20] and a graduate of Boonton High School.[citation needed] He is married to Dr. Sally Hurwitz, formerly an associate dean at the Mary Lou Fulton Teachers College at Arizona State University.[21]
Legal offices | ||
Preceded by Stanley Feldman |
Justice of the Supreme Court of Arizona 2003–2012 |
Succeeded by Ann Timmer |
Preceded by Rebecca Berch |
Vice Chief Justice of the Supreme Court of Arizona 2009–2012 |
Succeeded by Scott Bales |
Preceded by Mary Schroeder |
Judge of the United States Court of Appeals for the Ninth Circuit 2012–present |
Incumbent |


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Toronto Mayor Now Sorry for 'Graphic Remarks'
Rob Ford apologized for lewd comments made to reporters on live TV.
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Product News: Communication Systems & Equipment, Mechanical Power Transmission, Electronic Components & Devices
Distribution Amplifiers (1.2 GHz) are DOCSIS 3.1 compliant.
Press Release Summary:
May 16, 2014 - AC1500 distribution and A2500 distribution trunk amplifiers ensure that downstream frequency band reaches up to 1.2 GHz and upstream is upgradable to 200 MHz. Both can be equipped with Remote Ingress Switching (RIS) system that allows ingress detection and countermeasures at headend. For management feature diversity, amplifiers can also be equipped with intelligent transponders with measuring capabilities as well as programmable signal and ingress monitoring.
Original Press Release
Teleste at ANGA COM 2014: Teleste Expands Its Portfolio of DOCSIS 3.1 - Compliant Nodes and Amplifiers
Press release date: May 8, 2014
TURKU, Finland – Teleste introduces new 1.2 GHz distribution amplifiers for an outstanding all-around performance. The AC1500 and AC2500 amplifiers offer flexible management and improved ingress control that result in increased operational savings for operators.
At ANGA COM 2014, Teleste Corporation, a leading provider of video and broadband technologies and related services, will introduce its new AC1500 and AC2500 amplifiers for ultimate capacity enhancement with 1.2 GHz upstream transmission. ANGA COM 2014 takes place 20-22 May in Cologne, Germany. Teleste welcomes you to learn more and visit us at stand E19 in hall 10.2.
Consumer demand for faster broadband connections is constantly increasing and operators need to invest in more network capacity to keep up with the competition for customers. Supporting capacities of 10 Gbit/s downstream and 1Gbit/s upstream, the upcoming DOCSIS 3.1 standard will allow operators to greatly enhance their networks' performance. However, despite growing capacities, broadband services are far too often disrupted by noise that degrades the quality of services and irritates end-users. To increase customer satisfaction and reduce churn, it is of great advantage to operators if they can control service distruptions and block ingress noise from spreading around their networks.
Teleste's new AC1500 distribution and A2500 distribution trunk amplifiers take full advantage of the DOCSIS 3.1 standard. They ensure that the downstream frequency band reaches up to 1.2 GHz and the upstream is easily upgradable to 200 MHz. Both amplifiers can be equipped with Teleste's Remote Ingress Switching (RIS) system that allows low-cost ingress detection and countermeasures at the headend. For a broader range of management features, the amplifiers can also be equipped with intelligent transponders with comprehensive measuring capabilities, and programmable signal and ingress monitoring.
Visit Teleste's event site to find out more [http://www.teleste.com/teleste-anga-com-2014
About Teleste
Teleste is an international technology company that develops and offers video and broadband technologies and related services. Our supply of technology contributes to the convenience and safety of daily living. Our core business is video - image and data processing, transfer and management. Our customer base consists of cable and telecom operators, as well as public sector organizations. Our business is divided into two divisions, which are Video and Broadband Solutions and Network Services. In both areas, we rank among the world's leading companies and technological forerunners. Video and Broadband Solutions focuses on access networks and product solutions in video surveillance applications. Network Services offers comprehensive services for network design, construction and maintenance. In 2013, Teleste's net sales totalled EUR 192.8 million, and the company employed about 1,300 people. Teleste runs a worldwide network of offices and more than 90% of its sales are generated outside of Finland. The company is listed on the NASDAQ OMX Helsinki Ltd. For more information see http://www.teleste.com and follow @telestecorp [https://twitter.com/telestecorp on Twitter.
More information:
Hanno Narjus
Senior Vice President
Video and Broadband Solutions
Teleste Corporation
Tel +358-2-26-05-611
Press contact:
Mirkka Lamppu
CEM and Communications
Teleste Corporation
Tel +358-40-74-88-719


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Unfortunately there are times when pet owners, for many different reasons are forced to find a new home for their pet. Owners are highly encouraged to find ways to keep their pet but if they must re-home the pet they are asked to exhaust all other options before surrendering. Ask friends, family, neighbors, and co-workers first. Owners can use the Humane Society of Charlotte's iCare Program to help with the re-homing process. Also contact rescue groups to see if they can help.If these methods fail, or time has run out, and they must surrender their pets they may do so by bringing their pet to Animal Care & Control. Owners that surrender their animals will voluntarily release their ownership rights to Charlotte-Mecklenburg Police Department's Animal Care & Control. They will sign a legal document that terminates their ownership of the pet.If you are a pet owner that must surrender their animal and have exhausted all other options, please note the following:
Owners surrenders will be accepted Sundays from 1:00pm - 3:00pm and Wednesdays from 11:00am - 2:00pm. Our goal is for owners to retain their pets; to find out about possible assistance for your situation, or for more general information, please call 704-336-3799.
Animal medical records are EXTREMELY appreciated if available and are extremely helpful for the shelter staff in caring for the pet as well as trying to find it a new home. If you have these records, especially proof of rabies vaccinations and proof of spay or neuter, PLEASE BRING THESE WITH YOU.
Only the owner may surrender their pet.
Owners and their pet must reside in Mecklenburg County, including the incorporated towns.
Please bring pets on a leash or in a carrier when bringing them to the shelter.
Owners must provide a government issued photo ID. If that ID does not have a current address owners must bring something that has your current address on it in addition to their ID.
Owners will be asked several questions about the animal's history and personality which will help staff determine adoptability and structure of a new home.
Owners will be required to sign a legal Animal Owner Surrender form. This legal document signs over your ownership rights to the shelter and understand that your pet may be euthanized at any time after you surrender the pet to Animal Care & Control.


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Center for Breast Care
Seay Biomedical Building
2201 Inwood Road
2nd Floor, Suite 300
Dallas, Texas 75390-9183
Some of the world's best breast cancer specialists are at UT Southwestern Medical Center. Learn more about the health care professionals who can help you with your fight against the disease.
Ask our cancer experts any question about cancer.
Call 1-888-980-6050 or send an email.


text:
Thu, 27 May 2010
George and I discuss the reasons that we declare the index card the most valuable project management tool ever. I know this is probably old news but we are constantly asked "Why Index Cards".
If you have never experienced a true project card wall it is time to "Kick it Old School". Enjoy -bob payne |
Thu, 13 May 2010
George and I discuss the "Three Basic Things" that you need to understand to implement agile. The "Three" theme never gets old. Much is said about agile but I think George says it best. "Simple but not easy" -bob |


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US D512212 S1 Resumen disponible en Reclamaciones(1)
Descripción FIG. 1 is a front perspective view of a portion of a shoe upper showing my new design; FIG. 2 is a rear perspective view thereof; FIG. 3 is a side view thereof; FIG. 4 is a top view thereof; and, FIG. 5 is a front view thereof. The uneven broken line in the Figures bounding the shaded region represents an unclaimed boundary of the design. The uneven broken line showing of the remainder of the shoe is for illustrative purposes only and forms no part of the claimed design. Otras citas
Citada por
Girar |


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You know what that means. It's time to find a way to not let Todd McShay and Mel Kiper haunt you 24/7. You're going to be seeing A LOT of these guys, whether you like it or not. I don't care if you avoid ESPN for the next 2 months, they'll still find a way into your life. Go ahead, try. You'll think you're safe watching "Orangutan Island" on the Animal Planet. Then all of a sudden, Todd McShay swings down from a branch screaming, "4.3 SPEED! 3RD ROUNDER IN MY FULL MOCK DRAFT AVAILABLE TO READ FOR SUBSCRIBERS ONLY ON ESPN INSIDER! 30 BENCH REPS!" It's unavoidable.
Go to class. Your teacher's going to ask you what you think of a topic. "Matt, have any thoughts on what Yeats is trying to say in this poem?"
"Well, considering his Irish heritage and ..." You're on the right track, then it happens: "Undersized for an NFL linebacker. If he were 6'1, you're talking about a potential first round pick here. Impressed scouts with his time in the 20 yard shuttle."
So good luck, but I think you'll be saying Mel Kiper's "strenth" instead of "strength" in no time.


text:
Related Titles
- Full Description
Canadian Semantic Web is an edited volume based on the first Canadian Web Working Symposium, June 2006, in Quebec, Canada. This volume includes but is not limited to the following popular topics: 'Trust, Privacy, Security on the Semantic Web,' 'Semantic Grid and Semantic Grid Services' and 'Semantic Web Mining.'
- Table of Contents
Table of Contents
- Preface.
- Program committee.
- Keynote session.
- Service
- Oriented Computing: Multiagent Foundation, Robust Applications, and Research Agenda.
- Technical session: Applications I.
- A Semantic Web Mediation Architecture.
- Applying and Inferring Fuzzy Trust in Semantic Web Social Networks.
- A Trust Model for Sharing Ratings of Information Providers.
- on the Semantic Web.
- Technical session: Applications II.
- A Distributed Agent System Upon Semantic Web Technologies.
- to Provide Biological Data Fulfilling the Needs of a Metadata Creator and Analyst 1) An Investigation of RDF Browsing and Visualization Tools.
- A Rule
- based Approach for Semantic Annotation.
- Evolution in the CoSWEN System.
- Technical session: Ontologies I.
- Integrating Ontologies by Means of Semantic Partitioning.
- Toward the Identification and Elimination of Semantic Conflicts for Integration of Ontologies.
- Incorporating Multiple Ontologies into the IEEE Learning.
- Object Metadata Standard.
- Ontoligent Interactive Query Tool.
- Technical session: Ontologies II.
- DatalogDL: Datalog Rules Parameterized by Description Logics.
- Resolution
- based Explanations for Reasoning in Description Logic ALC
- Completion Rules for Uncertainty Reasoning for the Description Logic ALC.
- Author Index.
- Errata
Please Login to submit errata.
No errata are currently published


text:
Accoring to the US Census Bureau, Molandes ranked #116,123 in frequency out of 151,671 surnames for which statistics were released from the 2000 Census. 139 people, or approximately 1 in every 1,940,734 individuals in the US had this surname in 2000.
Source: "Genealogy Data: Frequently Occurring Surnames from Census 2000", US Census Bureau.
Histopolis currently has 0 grave(s) with the surname Molandes.
The surname Molandes has a Soundex code of M453. The following 98 surname(s) may sound similar to Molandes since they share the same Soundex code.


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Happy, happy, happy New Year's resolution week. We all have something that we would like to be better in life. And if you don't think you do – well, that might be your answer: admitting there's an issue cause I promise there's something. I hope we all prosper in our goals and make 2015 a year to brag about.
A Camp Azalea resident was rebuffed in her attempt to have the Levy County Commission enforce rules on political signs still standing along roadways.
Toni Collins complained at a December commission meeting about the signs still up from the Nov. 4 general election and gave indications it was a candidate who lost the election.
Collins was back at the first commission meeting of the year to complain again about political signage.
Collector's show planned
The state has issued performance grades for the Levy County School District and the county's four high schools for the 2013-2014 school year – last year – and the news can be possibly confusing for parents who want to judge the quality of local schools.
It's time to renew old friendships and make new ones as the Cedar Key School gears up for its homecoming activities.
A parade at 4:30 p.m. Thursday, Jan. 22 gets things underway. All parade participants will line up along G Street at 3:30 p.m.
Everyone is invited to participate – residents, businesses, civic groups – because organizers say the bigger the better.
Manatee deaths appear to be down last year compared to the record numbers reported by state officials in 2013.
As of December, 2014, 368 manatee deaths were reported for the year by the Florida Fish and Wildlife Conservation Commission. One-hundred-twenty-five of those deaths were labeled as undetermined. Manatee infant deaths accounted for 99 mortalities. Sixty-seven were the result of collisions with watercraft. Twenty-six were attributed to natural causes and 24 died due to cold stress.
Unemployment rate was 7.1 percent in November,
The Supervisor of Elections office removed a mailbox from its lawn after the Florida Secretary of State said ballots can only be received in the supervisor's office.
County workers got a 2 percent pay increase that was back dated to Oct. 1, 2013. That was on top of a 3 percent increase they received 7 months earlier.
Month of January
Monroe Crossing will hold a benefit for Cedar Key School at 7 p.m. Jan. 14 at the school, Whiddon Avenue.
Pepper busters Daniel Barrand, Richard Baker, Kit Lane, Roger McDaniels and Milli Chapell spent their holidays eradicating the colorful Brazilian pepper plant from the area. This hardy foreigner has come into the state and is considered an invasive plant as birds eat and spread its red berries.


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Pastrami Reuben Melt
Recipe courtesy Damien McEvoy, The Salon and Grill, Las Vegas, NV
- The Best Of
- Vegetable oil, for grill
- 16 ounces sliced pastrami
- 8 ounces sauerkraut, drained
- 4 (6-inch) flour tortillas
- 6 ounces imported shredded Swiss cheese
- 6 ounces Russian dressing, recipe follows
- Russian Dressing:
- 1/2 cup mayonnaise
- 1/2 cup ketchup
- 1/4 cup minced green onions
- 2 tablespoons drained and chopped capers
- Dash hot sauce
Oil a grill or grill pan and preheat it to 400 degrees F.
Steam pastrami and sauerkraut together in a double boiler. Place tortillas on hot grill and divide half of the Swiss on top of the tortillas. Cook until cheese is melted. Divide the pastrami and sauerkraut mixture evenly on top of the melted cheese. Squirt Russian dressing evenly over each tortilla. Divide the remaining Swiss among the tortillas. Fold tortillas in half and cook until cheese is melted. Transfer to a cutting board and cut into wedges. Serve immediately.
Russian Dressing:Mix all ingredients together in a bowl. Cover and refrigerate until ready to serve. Transfer to a squirt bottle before using on tortillas.
Professional Recipe: This recipe was provided by a chef, restaurant or culinary professional and makes a large quantity. The Food Network Kitchens chefs have not tested this recipe in the proportions indicated and therefore cannot make any representation as to the results.
Recipe courtesy Damien McEvoy, The Salon and Grill, Las Vegas, NV
Cooking Tips
More Recipes and Ideas
Pink's Polish Pastrami Reuben Dog
Recipe courtesy of Bobby Flay
Turkey Pastrami on Pumpernickel
Recipe courtesy of Guy Fieri
Deli Pastrami Potato Skins
Recipe courtesy of Food Network Kitchen


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We believe in the power of bicycles to make the world a better place.
That's why our Bicycle Racks are designed to make it easier to simply get out and go.
Easy Installation
Trunk or hitch, Saris racks are intuitively designed for easy installation right out of the box. Especially helpful when you leave your instruction manual somewhere far behind.
Highly Efficient
We think bikes belong on the back of a vehicle, not the roof. This creates less drag for better fuel efficiency. And easy-on, easy-off accessibility saves you precious energy, too.
Fits Most Vehicles
Whatever you drive you're likely to find a Saris rack that's capable of carrying your bike safely and securely. How do we know? We personally fit test our racks on vehicles worldwide.
The Many Colors of the Saris Bones: Red
Here at Saris we believe strongly in the power of the bicycle, and no one understands that better than World Bicycle Relief.


text:
Released: May 01st, 1997
Running Time: 76
Director: Rex Borsky
Company: Rosebud
Distribution Companies: Evil Angel
Mikki Malone, Shawnee, Tom Byron, Lana Sands, Cortknee, Pandora (I)
Critical Rating: AA
Genre: All-Sex
Even though the women are hot, the Neanderthal choking and drag-by-the-hair antics of T.T. Boy are not. Granted, there are some vids that play the erotic side of dominance and control, but this is not erotic. Mix in the bored look on Pandora's face and you have failed the Crash Test.


text: 470 Nationals 2013, Bay of Islands - Image: Garry Coleman Rob Burn This site and its contents are © Copyright TetraMedia Pty.Ltd. All Rights Reserved. Photographs are copyright by law, if you wish to use an image from Sail-world.com, Powerboat-world.com or marinebusiness-world.com, Contact us. Click Here to close this window |


text:
IEC 61850 independent multivendor interoperability testing for Scandinavian utilities
Publication: Communication › Conference paper
Downloaded 411 times
Nicholas Etherden ; Carl Öhlen
IEC 61850 Independent Interoperability Testing
STRI_IPTS_paper.pdf, 190 KB, application/pdf
The main objective of the IEC 61850 standard for power utility automation communication is to "provide a framework to achieve interoperability between the Intelligent Electronic Devices supplied from different suppliers" [1]. Many users expect conformance tested devices to be "plug and play" with no interoperability issues. Present experience however shows that conformance testing only reduces the number of interoperability issues and additional measures are needed to ensure cooperation of multi-vendor devices. This article is about key issues involved with creating a test facility for interoperability testing of IEC 61850 devices and systems involving different vendors. A testing strategy to ensure interoperability is presented.
Original language | English |
Publication date | 24 Oct 2008 |
Number of pages | 4 |
State | Published |
Conference | International Protection Testing Symposium |
Country | Austria |
City | Klaus |
Period | 23/10/08 → 24/10/08 |
Internet address | http://www.omicron.at/en/events/omicron-hosted/ipts-itmf/ |
Event (Conference etc)
International Protection Testing Symposium
Oct. 23 2008 - Oct. 24 2008
Klaus, AustriaEvent (Conference etc): Conference


text:
Page Header
Museum of Science
Listen to:
Making Stuff!
Publication Date
December 2, 2010
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Audio Content Description
Material scientists Dr. Amy Moll and Dr. Ainissa Ramirez join us for Nova's Making Stuff Day. They talk about their own research on how to make electronics stronger, smaller and greener.


text:
| Format | Pages | Price |   |
Hardcopy (shipping and handling) | 16 | $49.00 |   ADD TO CART | |
Standard + Redline PDF Bundle | 32 | $58.80 |   ADD TO CART |
Historical Version(s) - view previous versions of standard
Significance and Use
This test method provides a laboratory test for determining the relative carpet dirt removal effectiveness of residential central vacuum cleaning systems when tested under standard conditions and on representative types of carpets.
This laboratory test method may not give a representation of carpet embedded dirt cleaning effectiveness in the home.
In order to provide a uniform basis for measuring performance as described in 1.2, standardized test carpets and standardized test dirt are employed in this procedure.
The results reflect a non-loaded cleaning capability and may not be representative of cleaning capabilities under dirt loading conditions.
1. Scope
1.1 1.1 This test method covers only a laboratory test for determining the relative carpet dirt removal effectives of residential central vacuum cleaning systems when tested under specified conditions.
1.2 This test method is applicable to residential central vacuum cleaning systems intended for cleaning carpets.
1.3 This test method applies only to embedded dirt removal from carpets, not the removal of surface litter and debris.
1.4 The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conversions to SI units that are provided for information only and are not considered standard.
1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. X1.1.1 The purpose of this test is to determine a ratio of a carpet-embedded dirt removal effectiveness and a home-carpet embedded removal effectiveness rating which can be used for comparing one or more vacuum cleaners against a standard vacuum cleaner and determining correlation with laboratory ASTM tests. The results are representative of the geographic area covered by the test homes.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
ASTM Standards
D75 Practice for Sampling Aggregates
E11 Specification for Woven Wire Test Sieve Cloth and Test Sieves
E177 Practice for Use of the Terms Precision and Bias in ASTM Test Methods
E691 Practice for Conducting an Interlaboratory Study to Determine the Precision of a Test Method
F608 Test Method for Evaluation of Carpet Embedded Dirt Removal Effectiveness of Household/Commercial Vacuum Cleaners
F655 Specification for Test Carpets and Pads for Vacuum Cleaner Testing
F884 Test Method for Motor Life Evaluation of a Built-In (Central Vacuum) Vacuum Cleaner
F922 Test Method for Motor Life Evaluation of an Electric Motorized Nozzle
F1038 Test Method for Motor Life Evaluation of a Canister, Hand-held, Stick, and Utility Type Vacuum Cleaner Without a Driven Agitator
F1334 Test Method for Determining A-Weighted Sound Power Level of Vacuum Cleaners
F1409 Test Method for Straight Line Movement of Vacuum Cleaners While Cleaning Carpets
UNSPSC Code
UNSPSC Code 47121602(Vacuum cleaners)
ASTM International is a member of CrossRef.
Citation Format
ASTM F1284-09, Standard Test Method for Evaluating Carpet Embedded Dirt Removal Effectiveness of Residential Central Vacuum Cleaning Systems, ASTM International, West Conshohocken, PA, 2009, www.astm.org
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text:
Mission Focus
Web Tools
Research Support
Daily News
Military & Government Sources Defense Systems Daily Daily coverage of the global activities across the international Defence & Aerospace scene EarlyBird A daily (duty days) concise compilation of the most current published news articles and commentary concerning the most significant defense and defense-related national security issues. Available by 0515 hrs. Government Executive Government's Business News Daily and the Premier Web Site for Federal Managers and Executives Marine Corps News Provides news and information of interest to the United States Marine Corps. Navy Newsstand Navy Top Stories Pacific Stars and Stripes A daily newspaper since 1945 Spotlight on Military News and International Affairs Provided by Canadian Forces College
Newspaper Direct Press Display provides instant online access to today's newspapers from around the world in full-color, full-page format. The collection includes nearly 1,000 newspapers from Europe, Latin America, Asia, the Middle East, and the U.S. Available through Library Intranet.
OnlineNewspapers.com List top newspapers by global geographic locations Newspaper Archives on the Web News archives, information about archives and resources about archiving the news NewsPapers.com Searchable by topic or place NewsDirectory Browse newspapers by country, browse magazines by subject and by region NewsLink Newspapers and magazines by location or topic, worldwide Newseum: Today's Front Pages 521 front pages from 44 countries presented alphabetically New York Times USA Today Wall Street Journal The Washington Post The Washington Times Access The Library Intranet for following Current & Historical Newspapers: Asian Wall street Journal, current Atlanta Constitution, 1986-1939 Boston Globe, 1872-1925 Chicago Tribune, 1849-1986 Christian Science Monitor, 1908-1995 & current Hartford Courant, 1764-1984 Irish Times, 1959-2007 Los Angeles Times, 1881-1986 & current New York Times,1851-2005 & current Pittsburgh Courier, 1911-2002 San Francisco Chronicle, 1865-1922 Seattle Post-Intelligencer, 1990- current The Guardian and the Observer, 1791-2003 USA Today, current Wall Street Journal,1889-1991 & current Washington Post, 1877-1992 ¤t
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text:
Please use this identifier to cite or link to this item: http://hdl.handle.net/1811/51089
Files | Size | Format | View |
ARV-CAA-Agenda20070418.pdf | 18.81Kb |
View/ |
Title: | Council on Academic Affairs. Agenda. April 18, 2007 |
Creators: | Ohio State University. Council on Academic Affairs |
Contributors: | Winer, Brian L.; Smith, W. Randy |
Subjects (LCSH): | Ohio State University -- Curricula |
Issue Date: | 2007-04-18 |
Publisher: | Ohio State University |
Series/Report no.: | Ohio State University. Council on Academic Affairs |
Abstract: | This is the agenda for the Council on Academic Affairs' meeting on April 18, 2007. This document shows that, along with other topics, there was continued discussion of the Report of the Committee on the University-Wide Review of Undergraduate Education, including Bachelor of Science templates from other colleges. |
URI: | http://hdl.handle.net/1811/51089 |
Rights: | This object may be copyright-protected. Permission to reuse, publish or reproduce the object must be obtained from the object publisher or copyright holder. |
Items in Knowledge Bank are protected by copyright, with all rights reserved, unless otherwise indicated.


text:
++ Through Schala's Eyes ++
Credits & Info
- Date
- 02/29/2008
- File Info
- Song
- 2 min 57 sec
- Score
- 4.23 / 5.00
Related Content
Heard in 1 Entry!
The Orange Box Collab by assasinrabbit
- Movie
- Rated T
- 35,790 Views
View all submissions featuring this audio file.
Licensing Terms
- Attribution:
- You must give credit to the artist.
- Noncommercial:
- You may not use this work for commercial purposes unless you make specific arrangements with the artist.
- Share Alike:
- If you alter, transform, or build upon this image, you may distribute the resulting creation only under a license identical to this one.
- Score:
- Rated 4.23 / 5 stars
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- 11,138 Plays | 983 Downloads
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Author Comments
I'm not huge on doing remixes to be honest. However, with a bajillion versions of this song, and me knowing just how much I love this song, I decided to give it a go.
Please leave comments. I put some decent effort in this one and am curious what you all think.
This song is a remix of Schala's Theme in Chrono Trigger.
Rated 5 / 5 stars
Song was cool; nice and mellow, yet sticking near the original. Title was clever.
Rated 5 / 5 stars
Nice work
Ah, such a good piece, and you remade it brilliantly. I love your variations to it, especially the drums.
Thanks are in order, yet again.
Rated 5 / 5 stars
Damn. Chrono Trigger Shyt!!
This was AWESOME. Brings back memories. Thanx for that Nostalgic Feeling.
*Cee-Bear 2008*
Rated 5 / 5 stars
ah, chrono trigger,
i tried playing it once, on an iso rom on my computer, it worked and i was playing, but i got stuck in a certain area and couldnt finish. not a great game in my bad experience but im sure it would have been great if i owned it when it frst came out. I love this song, i could listen to it in loop forever.
Rated 5 / 5 stars
Its BEATIFUL ,I love this music, 10/10 ,100/100


text:
Distinguished LectureStraight Down the Crooked Path: The Dynamic Process of Commercializing ResearchDr. Michael McCorquodaleCTO and Founder of Mobius Microsystems, Inc. |
Friday, September 25, 2009 2:30pm - 3:30pm 1200 EECS Add to Google Calendar |
Dr. McCorquodale is visiting Michigan as a special Homecoming guest of the College of Engineering and will give this lecture during his visit. He is the College of Engineering Recent Engineering Graduate Alumni Award Winner for 2009. |
About the EventThe past, present and future of Mobius Microsystems is presented as a backdrop for discussing the challenging and dynamic path of commercializing university research. Mobius is an analog semiconductor device company and was borne out of research at the U. of Michigan over five years ago. Its flagship technology enables all-silicon solid-state oscillators to replace piezoelectric quartz-referenced oscillators, primarily in consumer electronics. However, Mobius� product embodiments based on this enabling technology have varied over the years. Against this backdrop, that which will seem to be nearly a random walk is dissected and a framework for understanding the process of commercializing research is presented. As opposed to previous talks Dr. McCorquodale has presented on this topic, this talk will focus on understanding the business concepts, development cycles and external factors which play critical and often serendipitous roles in the development of a new venture from research. In particular, the concept that research commercialization is a �technology push� will be presented and contrasted to a �market pull� in which established industry engages for its product development efforts. The talk will conclude with recommendations for those seeking to commercialize research while leaving adequate of time for questions and answers. |
BiographyDr. Michael S. McCorquodale is the CTO and founder of Mobius Microsystems, an analog semiconductor device company based in Silicon Valley and with a design center in Ann Arbor. Mobius was founded based on Dr. McCorquodale�s research at the University of Michigan in precision analog integrated circuits for frequency generation and quartz replacement. On that work, he has published over 25 technical articles and holds inventorship on over 30 issued and pending U.S. patents. Governor Granholm awarded Mobius for the Largest High-Tech Job Creation in Michigan in 2005 and the SBA recognized Mobius for developing the Innovation of the Year in Michigan in 2006. EDN recognized Mobius� all-silicon spread-spectrum clock generator as one of the �Hot 100 Products� of 2008. Dr. McCorquodale earned the B.S.E. degree with honors from the University of Illinois at Urbana-Champaign and the M.S.E and Ph.D. degrees from the University of Michigan, all in Electrical Engineering. He was recently awarded the Young Alumni Achievement Award by the Electrical and Computer Engineering Department Alumni Board at the University of Illinois at Urbana-Champaign. |
Additional InformationContact: Catharine June Phone: 734-936-2965 Email: firstname.lastname@example.com Sponsor: Electrical and Computer Engineering Open to: Public Web Page: http://www.mobiusmicro.com |


text:
MandM Direct is one of the UK's leading fashion and sports retailers selling your favourite top brands - Bench, Firetrap, Timberland, Fred Perry, adidas, Nike, Puma, Henleys, Berghaus and loads more, all with savings of up to 75% off UK recommended retail prices.
The rating shows just the review scores in the category or product area selected.
Ratings guide
All Feefo reviews are gathered anonymously from genuine customers. Read more about how our review system works.
Good quality
Lightweight summer shirt,
Great fast service
Fast efficient
Delivered on time and of high quality02-Jan-2015Always impressed with quality of products02-Jan-2015Always impressed with quality of products
See above
I ordered the items on a Saturday and the following Wednesday morning they arrived. All the shirts, brand name Kangaroo Poo, where well presented and I have been able to use them as the sizes where excellent.
Lovely shirt great price!
Very good
Need to improve their delivery services. Their drivers do not communicate well on where your parcel was delivered if you are not around.
fast delivery and fast order very pleased
Came the next day!! Good vaule for money thanks
just as I orderd
Product of item as advertised.
This was on offer so a great price at £9.99 I would order kangaroo poo again lol
Will be using you again..!
Great value, good service
recipitent pleased
Fantastic value for money.
Great shirt, my usual size was a good fit and looks great.
Great products great prices quick delivery
First class service.


text:
Special rates require proof of eligibility at check-in.
You're one step closer to paradise...
Kim Steutermann Rogers on Wed 2/20/2013
This is one of the things I love about Lahaina: the depth of the place. You cannot walk down Front Street without running into it. The town has history. It oozes from the break wall running in front of the wooden storefronts. It seeps from the rock and coral Masters' Reading Room, built in 1834.
Kim Steutermann Rogers on Fri 1/25/2013
In my three-year-old blog post, I acquiesced to the food photography trend by taking my own and allowing that the act of photographing food was akin to photographing a beautiful Hawaiian sunset or Hawaiian monk seal snoozing on the beach. It captured a moment in time. It served as a keepsake. It recorded a special moment. But hot dogs?
Kim Steutermann Rogers on Fri 1/11/2013
Last night, trying to wedge a chore between my Outrigger day job and an evening dinner appointment, I fired up the riding lawn mower. Well, truthfully, the husband fired up the mower, and I hopped on to swing around the yard, listening to one of my favorite podcasts--Writers on Writing—as I did so. I soon recognized a problem.
Kim Steutermann Rogers on Wed 10/10/2012
While we're on the subject of 'ulu—breadfruit—I thought I'd share Sam Choy's recipes from the Breadfruit Festival. He was so generous about handing them out that I doubt he'd have a problem with me posting them here, but, if you do, Sam, let me know, and I'll pull them down.
Kim Steutermann Rogers on Mon 10/8/2012
One not-so-rare discovery that I made yesterday along Kauai's Mahaulepu coastline was breadfruit. This discovery came after a weekend on Big Island enjoying the Breadfruit Festival, where I discovered 1) numerous tasty ways to eat breadfruit; and 2) an ancient agro-forest once ran a full 1/2 mile wide by 18 miles long growing--seat belts low and tight, people--breadfruit.
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text:
Houston Bus Drivers So Afraid Of Bullies They Hold A Protest
Houston bus drivers have had enough. Fights, drug use, weapons, students jumping out of moving buses, even assault against drivers have plagued the Texas city's school district. About 30 drivers rallied outside of Houston's school district headquarters Tuesday to ask administrators for help.
Auto journalists flee L.A. Auto Show ahead of Occupy L.A. takeover rumor
The buzz on the LA Auto Show floor this morning isn't about 650 HP Mustangs or smokin' booth babes. It's about the Occupy protests. Word is, they're marching toward the LA Convention Center, so out-of-town journalists and PR people are fleeing for the airport, fearing they'll be trapped if they wait too long.
French motorcyclists give new regulations le finger
Some 75,000 French motorcyclists embraced their country's national pastime of protesting last weekend, spurred by proposed government rules that would require florescent vests for all riders and massive license plates to aid unmarked speed cameras. Maybe that's where the Vasoline should go? Thanks Mike!
Protesters in Bahrain reportedly burn down Chrysler dealership
There are reports of "red flames" bursting out of a Chrysler dealership in Bahrain. Protesters were heard to say "Up with democracy, down with The Detroit News!"
Rioting Pro Tip No. 87: If you run over an Egyptian protester, don't…
There are a few videos of Egypt's security forces running over protesters, but this guy didn't get the memo that you shouldn't stop after you do it. Yep, they flipped the bitch.
Late Night Los Angeles: Bug-a-Mino
Spied at the beginning and end of a Midnight Ridazz urban cycle crawl was this fine example of German engineering meeting California utility. Long buried in the memory of a cell phone, this image is only now resurfacing from an Echo Park past to work its way into the pantheon of minos. We pedaled the ride on a…
Go, Go, Mister Show! Group Wants to Shut Down Chicago Auto Show
Guess we'd better make other plans for this week, lest we run afoul of one pro-bicycle group that aims to shut down the Chicago auto show. The group, AutoShowShutdown.org recently launched a web parody of the Chicago show's site, on which they provided counterpoint to the show site's content. The group even rebuffed…


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Lower bounds on blow up solutions of the three-dimensional Navier–Stokes equations in homogeneous Sobolev spaces


text:
Welcome to orchid ownership! Whether you received your new plant as a gift for hosting Easter brunch or as part of a festive Easter basket, you're probably asking yourself the same question: Now what?
First of all, don't worry if you don't consider yourself a "plant person." Phalaenopsis orchids are relatively low maintenance plants and you'll find you can easily adapt to a simple care routine. Here are four things to keep in mind.


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Neonatal symptoms in medium chain acyl coenzyme A dehydrogenase deficiency. | |
MedLine Citation:
PMID: 8215568 Owner: NLM Status: MEDLINE |
Medium chain acyl coenzyme A dehydrogenase (MCAD) deficiency has not been thought to be associated with significant neonatal symptoms. To determine the validity of this, all known MCAD cases from New South Wales were reassessed. A total of 16 confirmed and three presumed cases has been identified in New South Wales, from 15 families. The casenotes of patients were reviewed, and where possible the mothers interviewed, either directly or by telephone, to obtain information about neonatal events. Six of the 16 confirmed cases had significant neonatal symptoms, with onset from 17 hours to 3 days of age. All required intravenous dextrose and four of the six needed other interventions, including hospital transfer. One baby died. All six were breast fed, but so were five of the eight asymptomatic neonates for whom information was available. Four of the six symptomatic neonates were homozygous for the common MCAD mutation, an A to G transition at position 985, and one was heterozygous. It is concluded that serious neonatal symptoms are common in MCAD. Newborn siblings of MCAD cases must have careful monitoring and support during the first few days of life. |
B Wilcken; K H Carpenter; J Hammond |
Related Documents
15080518 - Neonatal gastric perforation. 15067298 - Spontaneous neonatal chylothorax treated with octreotide in turkey: a case report. 16564408 - Clinically relevant physiology of the neonate. 16971078 - Acute osteomyelitis, septic arthritis and discitis: differences between neonates and ol... 20953338 - Infant symbolic play as an early indicator of fetal alcohol-related deficit. 12784078 - Epilepsy surgery in infancy. a review of four cases. |
Publication Detail:
Type: Journal Article |
Journal Detail:
Title: Archives of disease in childhood Volume: 69 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 1993 Sep |
Date Detail:
Created Date: 1993-11-03 Completed Date: 1993-11-03 Revised Date: 2009-11-19 |
Medline Journal Info:
Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: ENGLAND |
Other Details:
Languages: eng Pagination: 292-4 Citation Subset: AIM; IM |
Children's Hospital, Sydney, Australia. |
Export Citation:
APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Acyl-CoA Dehydrogenase Fatty Acid Desaturases / deficiency*, genetics Female Humans Hypoglycemia / etiology* Infant, Newborn Male Muscle Hypotonia / etiology* Mutation / physiology Sleep Stages* Vomiting / etiology |
Chemical | |
Reg. No./Substance:
EC 1.14.19.-/Fatty Acid Desaturases; EC 18.104.22.168/Acyl-CoA Dehydrogenase |
Comments/Corrections |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero.
Next Document: Annual audit of three year outcome in very low birthweight infants.


text: Looking for a great price on All You magazine?! Head over to the All You magazine site here where they are offering a special rate of only $1 per issue! All You is know for being packed with coupons making them an essential moneymaker if you even use one or two of the high value coupons inside the publication. Head here to check this deal out and pick up your subscription.


text:
Software Specification | ||
Author | sagasoft | |
Company | sagasoft | |
Platform | Windows 9x/Me/2000/NT/XP/2003 | |
Date Added | 2005-11-09 | |
Website | http://www.sagasoft.net | |
Views | 3103 | |
Category | Audio & Video > Rippers & Encoders | |
Price | $24.95 |
Other Software's by This Author : |
Power CD to MP3 Maker 1.00 Power CD to MP3 Maker is a powerful and extremely ease-to-use tool for converting audio CD tracks to audio format MP3, WAV, WMA and OGG. Power ID3 Editor 1.00 Power ID3 Editor is a full featured and ease-to-use tag editor for MP3, WMA and OGG files. Power MP3 Cutter Joiner 1.00 Power MP3 Cutter Joiner is a powerful and ease-to-use audio editor. It builds audio cutter and audio joiner in one software. Power MP3 WAV Converter 1.10 Power MP3 WAV Converter is a super and ease-to-use tool that directly converts audio format MP3, WAV, WMA, OGG from one format to another. Saga CD Ripper 1.04 Digitally rip audio CD tracks to audio format MP3, WMA, WAV, OGG Power Video to Audio Converter 1.03 Extract part or whole audio from video file to MP3, WMA, WAV, OGG Saga MP3 Cutter 1.00 A powerful and ease-to-use MP3 WMA WAV OGG batch cutter Power MP3 Joiner 1.00 A powerful and ease-to-use MP3 WMA WAV OGG joiner |


text:
we get it... daily
February 21, 2005
I hate to advocate weird chemicals, alcohol, violence or insanity to anyone... but they've always worked for me.
Hunter S. Thompson
1937 - 2005
Shhhhhh! A long delayed opening... |
Read the Lies
Read the Shouts
Read the Archives
Read the Static
Read the Financials


text:
Reply To This Post Return to Posts Index VegSource Home
Governmental managment of the economy is not free market capitalism. The federal reserve is providing money to banks at a low interest rate so that the banks can loan it out to citizens at a higher interest rate. That is a nice deal for the banks, but it kind of stinks for the citzens. The problem with the economy is that the citizens have become over-extended and pushed too far into debt. The federal reserve's response is to work with the banks to push citizens even further into debt. Who is the federal reserve working for? The banks or the citzens? Ooops, forget that. I have already answered my own question (see following news quote). It marked the third in a series of innovative auctions the Fed began last month as a way to provide cash-strapped banks with the reserves they need. The hope is that the increase in resources will keep banks lending to consumers and businesses and prevent the credit turmoil that hit in August from pushing the country into a recession. Reply To This Post Return to Posts Index VegSource Home


text:
Leadership and Excellence
in Patient Care and Research
To provide excellence in patient care and leadership in scientific investigation of cutaneous lymphomas that will lead to greater knowledge and the development of new therapies to improve the survival and the quality of life of our patients.
The Stanford Multidsciplinary Cutaneous Lymphoma team offers expert treatment for patients with cutaneous lymphomas, including mycosis fungoides, Sezary syndrome,
CD30+ lymphoproliferative disorders (lymphomatoid papulosis and anaplastic large cell
lymphoma), subcutaneous panniculitis-like T-cell lymphoma, gamma-delta T-cell lymphoma, CD8+ aggressive epidermotropic T-cell lymphoma, NK/T-cell lymphoma, other unspecified cutaneous peripheral T-cell lymphomas, and cutaneous B-cell lymphomas. Our physicians subspecialize in treating these types of cancers, and have extensive expertise in handling the most complicated cases. Care among specialists is tightly integrated.
Read more about the Stanford Cutaneous Lymphoma Program 2013 (pdf) More>>
What's New
- New NCCN Practice Guidelines in Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorder
2/2015 - Newly released National Comprehensive Cancer Network (NCCN) Practice Guidelines for Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorder is now available (see links to pdf below).
- Updated NCCN Practice Guidelines in Mycosis Fungoides/Sezary Syndrome and Cutaneous B-cell Lymphoma are available.
The National Comprehensive Cancer Network (NCCN) is an alliance of 21 of the world's leading cancer centers (see list below) dedicated to improving the quality and effectiveness of care provided to patients with cancer. NCCN institutions work together to provide physicians and patients with up-to-date management guidelines that would lead to better care and improved quality of life for cancer patients. The development of the NCCN practice guidelines are based on available scientific evidence integrated with the experience and judgment of the clinical experts in the alliance. These cancer guidelines are utilized by clinicians worldwide and serve as an important standard-of-care resource. The NCCN institutions experts have pioneered and lead the concept of multidisciplinary team approach to patient care and believe that the best cancer management is the result of integration of programs in clinical care, research, and education.
For the first time in NCCN history, a practice guideline in mycosis fungoides/Sezary syndrome (MF/SS) and primary cutaneous B-cell lymphoma (CBCL) have been developed and is available on the NCCN website. Again, these guidelines embody the practice patterns in the 21 expert institutions in the NCCN alliance and integrates available scientific evidence in the management of patients with MF/SS and CBCL. The current guideline has been updated this year and includes the revised staging system and updated recommendation for diagnosis and staging evaluations. The treatment recommendations are stratified by clinical stage and other key prognostic factors. In a given clinical stage, available treatments are presented in an algorithmic fashion as primary treatment options and choices for refractory or progressive disease. This MF/SS practice guideline will serve as an important standard-of-care resource not only for clinicians and patients, but also for medicare and other health insurance providers. Medicare and insurance carriers refer to the NCCN practice guidelines for approval and reimbursement of cancer treatments. Thus, the clinicians who follow the NCCN guidelines will increase the chance of receiving authorization and reimbursement for treatments in the care of our patients with MF/SS and CBCL. These guidelines will be updated as new treatments and scientific evidence are available that justify incorporating the information in clinical practice.
The next skin topic that will be addressed by the NCCN NHL panel is to develop a clinical practice guideline for the CD30+ lymphoproliferative disorders. Please visit the official NCCN website at "nccn.org" for more information about NCCN and its resources and activities. For MF/SS practice guidelines, please go to the "NCCN Clinical Practice Guidelines", then click on "Non-Hodgkin's Lymphomas".
Youn H. Kim, MD
Member of the NCCN NHL Panel
Joanne and Peter Haas Jr. Professor for Cutaneous Lymphoma Research
Director of the Multidisciplinary Cutaneous Lymphoma Program
Stanford Cancer Institute, Stanford, California
- Review of the Treatment of Mycosis Fungoides and Sézary Syndrome: A Stage-Based Approach (~2MB PDF)
- NCCN Clinical Practice Guidlines in Oncology - Non-Hodgkin's Lymphomas v.4.2014 (PDF)
- NCCN Practice Guidelines in Oncology – Mycosis Fungoides/Sezary Syndrome v.2.2015 (PDF)
- NCCN Practice Guidelines in Oncology - Primary Cutaneous B-Cell Lymphoma v.2.2015 (PDF)
- NCCN Practice Guidelines in Oncology - Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders v.2.2015 (PDF)
- Slides of Dr. Youn Kim's recent presentation at the 2014 LA MetroDerm Meeting, February 24, 2014
- Slides of Dr. Youn Kim's recent presentation at the 2013 PDA Annual Meeting, August 17, 2013
- Slides of Dr. Youn Kim's recent presentations at the American Academy of Dermatology Annual Meeting, March 2013
- Slides of Dr. Youn Kim's recent presentation at the Dana Farber/Brigham and Women's Cancer Center, May 2013


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Comfort and content live within smiles. (…) Read more »
Tagged: venice
California Love
Dec 04, 2014This post comes from our Australia contributor, Miann Scanlan. Follow along with her on Instagram @freepeopleaustralia! (…) Read more »
Behind the Scenes with Jessica Hart in LA!
Jan 19, 2012Back detail of the beautiful Bella Donna crochet dress. I love the laid back cali vibe of these two outfits… up top, the fp denim cutoffs, destroyed tee, sheer maxi bedroom jacket, northridge necklace and romana fest sandal; on the bottom, the must be dreamin tee, denim cutoff short and charlie converse. My favorite outfit! (…) Read more »
Behind the Scenes: August in Venice
Aug 18, 2011Here is the last batch of behind the scenes photos from our August catalog shoot in Venice with Guy Aroch! Featuring models Marloes Horst and Darla Baker, and members of the fp crew :) Behind the Scenes photos by Thomas Northcut. (…) Read more »
Inspiration: Architecture in Venice
Aug 17, 2011When I was reading the Guide to Venice that our producer put together, I was surprised when she said Venice is a city known for its decay – I've never been there and am not very familiar with it, but from what I've seen it looks beautiful and far from decay. But it's true, and (…) Read more »
Free People's Guide to Venice – Part 2
Aug 12, 2011Here is part two of the Free People Guide to Venice, put together by our producer! Read on for our tips on where to eat and more of our favorite things about Venice, and if you missed it be sure to check out part one of the guide featuring where to stay, landmarks, gondola riding (…) Read more »
Behind the Scenes: Venice Unmasked
Aug 11, 2011Behind the scenes of our August catalog shoot in Venice with Guy Aroch and models Marloes Horst and Darla Baker. Photos by Thomas Northcut. Did you guys see that we're selling the Italian masks now? They're amazing – go see them in our accessories shop. View the August Catalog. (…) Read more »
Venice Photography by Robert Crum
Aug 06, 2011I am always on the look-out for artists and photographers to post about on the blog, and it was by pure coincidence that I found this one about a week before our August Catalog dropped. Robert Crum is a fine art photographer, and his images of Venice blew me away. They almost look like paintings (…) Read more »
Free People's Guide to Venice
Aug 05, 2011Our talented producer has put together a beautiful Guide to Venice to share with you all, with tips on where to eat, where to stay and things to do while in Venice – with some Free People fun thrown in for good measure :) Read on for Part One of Free People's Guide to Venice! (…) Read more »
Behind the Scenes: Shooting in Venice with Guy Aroch
Aug 04, 2011I always love the behind the scenes photos from our catalog shoots… they allow us to see what was going on behind the lens and around the lens when the catalog photos were being taken. Here's a little taste of the atmosphere on the Venice shoot with Guy Aroch and models Marloes Horst and Darla (…) Read more »
Venice by Guy Aroch
Aug 02, 2011Venice has always been a city that intrigued me. I have never been there, but having studied a lot of Art History in college, it was always a place that signified fine art, gothic architecture, romantic music and exquisite fashion. The city's layout, with ribbons of canals running through it, and iconic imagery like the (…) Read more »
August Catalog Video by Guy Aroch
Aug 01, 2011Guy Aroch has done it again. His genius is clearly not limited to photography – his video to accompany our August catalog, shot in Venice featuring models Marloes Horst and Darla Baker, is breathtaking. It tells the story of two girls on a globetrotting adventure, exploring the streets and canals of Venice armed with maps (…) Read more »


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Driving Through Time - The Digital Blue Ridge Parkway
About this Image
Title | Flat Rock Trail Repair |
Date | 1970s |
Description | Men working on Flat Rock trail repairs near milepost 308, section 2J on the Blue Ridge Parkway. Image taken from the National Park Service, Blue Ridge Parkway Headquarters. |
Location |
Location Name: Section 2J Parkway Milepost: None
Latitude: 36.017117
Longitude: -81.880519 |
Creator Individual | Unknown |
Tags |
Avery County (N.C.)
Flat Rock Trail (N.C.) Park rangers People Photographs Trails Workers |
Credit | Courtesy National Park Service, Blue Ridge Parkway |


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eMeetings Home Schedule a Meeting
Doodle helps finding suitable dates for group events, e.g., an appointment, a conference call, a family reunion, etc. Doodle is particularly useful to people who do not use a common calendar. This service is free, requires no registration and no software installation.
For ASHRAE eMeetings, it is an excellent tool for identifying the optimal time for scheduling meetings.
Select 'Schedule an Event' on the Doodle home page and enter basic information about your meeting e.g. topic, duration, agenda.
Select Dates to be voted on by meeting participants.
Select time slots for your proposed meeting. When finished, you will receive an email containing the link to your poll.
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Final Sale
Lace Panel Ponte Dress
Sorry, this product is sold out online!
Sold Out Online:
Simultaneously elegant and casual, this dress is appropriate for occasions ranging from classy parties to boardroom presentations. The soft stretch ponte knit is a dream -- easy and comfortable while looking impeccably done up!
- Online Exclusive
- Smooth stretch ponte knit, lace overlay panels
- 3/4 sleeves
- Exposed back zipper
- Straight skirt shape
- Measures approximately 38 1/8" from shoulder to bottom hem.
- 78% Polyester/18% Rayon/4% Spandex; Lace: 50% Nylon/50% Rayon
- Dry clean.
- Imported
Item# 3148984
Love, love, love it!
This dress is awesome. I didn't notice any issue with the sleeves like other reviewers. The fabric is a bit thicker, which I love, and covers flaws nicely. Seems like great quality that will hold up over many wears. I got tons of compliments, too!
November 13, 2013
I love the different colors of black and charcoal grey combined with lace. I prefer dresses like this one that the material is not real thin and shows flaws. This dress is fitting and makes you look a bit slimmer. Love the Quality of this dress.
October 11, 2013
Too small in the sleeves.
I purchased a large and it was too large everywhere but tight in the sleeves.
October 11, 2013
This is a must have dress. The fit, quality fabric and style is right on. So glad I purchased it.
September 29, 2013
Not so prissy!
When I first saw this dress, I was afraid that it would be a little boring, but there was something I loved about it, so I ordered it anyway. I am so glad I did. It can be very elegant and dressy, but change the accessories and it can be work appropriate. Boots and tights can make it look more edgy. I love it!
September 27, 2013
Limited Ponte Dresses Are the Best!
I love this dress! It fits true to size, hugs your curves, and makes you look amazing. I have received so many compliments on this dress. Must have for work, or play.
September 27, 2013
A beautiful dress
I love this dress. It is elegant, sophisticated, but simple at the same time. Even though it is black and has a lot of lace it is approprate for work. The fabric is of high quality and the fit is good except for the length. I really wish it was about 1.5 inches longer!!
September 20, 2013
Good option for fall
After I got this dress, at first I thought it was a bit mature looking but then it grew on me. I like the 3/4 sleeves option which is sadly difficult to find. Material is of good quality and the fit is flattering, lace hides the flaws. I'm 5'7 and the length was similar to the model. Might be a bit short for the taller ladies. This dress is true to the limited size. The sleeves were a bit restrictive and I kept pulling it up over the elbows. The dress is very accommodating for the bustier ladies.
September 19, 2013
(1 Question & 1 Answer)
Product Q&A
Ask your questions. Share your answers.
Will this dress be re-stocked in a size Small?1 year, 7 months ago
Age: In my 30s
Body Type: Petite
Shopping Frequency: Frequently
Stamford, CT, USA
Thank you for the question! Unfortunately, no, we will not be getting any additional size small in this dress online.1 year, 7 months ago
New Albany, OH, USA
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Oracle is the world's most complete, open, and integrated business software and hardware systems company. For more information about Oracle, please visit oracle.com
Kimberly Pineda |


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Map of Al Bayda ,Libya
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Dress up Pink 3
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Ime: Alecia Beth Moore, better known by her stage name P!nk (also written as Pink)
Profession: American singer-songwriter
Rođendan: September 8, 1979
In summer of 2003, P!nk released a single from Charlie's Angel, "Feel Good TIme". The track peaked in the 60's on Billboards magazine's Hot 100 Singles.


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Out of time and space
Garrett Harris 6 p.m., April 20
Surviving Fragments of the Walls in Poznan. The medieval walls were demolished when the city expanded in the early 19th century. The surviving sections of walls can be seen in the Chopin Park in the south and on the Pond Street in the north. A bastion in the picture from the city wall system stands on the Stableman Street.
Posted November 14, 2011


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Play our fun game and find out if the one you like likes you back. Confide in us if you think you'd hit it off by clicking: Yes, No, or Maybe. We'll anonymously find out and let you know if the feeling is mutual. You have nothing to lose!
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You both said YES! The feeling is mutual. Now the rest is up to you! Say Hi and get the conversation started.
I'm fifty-two years and, live not too far from Boston College and have been selling technology solutions for over two decades. My journeys have taken me through the United States extensively, to attend school in Israel for a couple of years and to live for brief stints in Denmark and England. I still enjoy traveling. I'm not wealthy nor am I an executive but I'm kind, decent, warm and witty and have always taken the time to build people up and make them feel good about themselves. I enjoy people and they have always been drawn to me as well, but I'm not a "pack" person and as a rule I do not seek out large crowds. I love being in the company of my friends and I seem to have the gift of making them laugh and to think about things they had not previously considered. I've been exposed to "high culture" but it never really resonated with me. However, with the right woman, I'd go anywhere and try anything. For the right woman, I'd slay dragons or do anything in my power to make them happy and also to instinctively oppose anyone who tried hurt them, with every fiber of my being. A friend once told me that I make people feel "safe" and I took that as the highest of compliments. Someone close to me once observed that I think with a Jewish mind and I feel with a Jewish heart. That is accurate but I am not religiously observant at all...though I am cultural if not cultured. My politics tend to be moderate to liberal and I am a lifelong Democrat. I'm more comfortable with the music of Bruce Springsteen and the attire of a well worn pair of Levis but I'm flexible...or I can be flexible...to be happy or make some special to me smile.


text:
Systematic (IUPAC) name | |
(1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dionemethylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione | |
Clinical data | |
Nil | |
Oral | |
Pharmacokinetic data | |
Metabolism | Hepatic and CYP3A & CYP2B |
Half-life | 9-19.64 hours |
Identifiers | |
11079-53-1 | |
None | |
PubChem | CID 114787 |
DrugBank | DB01892 |
ChemSpider | 16736597 |
ChEBI | CHEBI:5834 |
Chemical data | |
Formula | C35H52O4 |
536.784973 | |
Physical data | |
Melting point | 79–80 °C (174–176 °F) |
0.66 mg/mL (20 °C) | |
(what is this?) (verify) |
Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort). Hyperforin (along with adhyperforin) is believed to be one of the three chief active constituents of St. John's wort -the other two being hypericin (along with pseudohypericin) and several flavonoid constituents.[1]
Hyperforin has only been found in significant amounts in Hypericum perforatum (St. John's wort) with other related species such as Hypericum calycinum (Greater St. John's wort or Aaron's beard) containing lower levels of the phytochemical. It is thought to be a reuptake inhibitor.[2] It accumulates in oil glands, pistils, and fruits, probably as a plant defense against herbivory.[3] Other Hypericum species contain low amounts of hyperforin.[4]
Hyperforin is a prenylated phloroglucinol derivative. The structure of hyperforin was elucidated by a research group from the Shemyakin Institute of Bio-organic Chemistry (USSR Academy of Sciences in Moscow) and published in 1975.[5][6] A total synthesis of the non-natural enantiomer of hyperforin was reported in 2010[7] and a total synthesis of the natural enantiomer was disclosed in 2012.[8]
Hyperforin is unstable in the presence of light and oxygen.[9]
Some pharmacokinetic data on hyperforin is available for an extract containing 5% hyperforin. Maximal plasma levels (Cmax) in human volunteers were reached 3.5h after administration of an extract containing 14.8 mg hyperforin. Biological half-life (t1/2) and mean residence time were 9h and 12h respectively with an estimated steady state plasma concentration of 100 ng/mL (approx. 180 nM) for 3 doses/d. Linear plasma concentrations were observed within a normal dosage range and no accumulation occurred.[10]
In healthy male volunteers, 612 mg dry extract of St. John's wort produced hyperforin pharmacokinetics characterised by a half life of 19.64 hours.[11] It appears to be metabolised, at least in part, by CYP3A and CYP2B into hydroxyl metabolites.[12]
Biologic effects[edit]
Reuptake Inhibition | |
Neurotransmitter | IC50 (nanomoles) |
Norepinephrine | 80 ± 24 |
Dopamine | 102 ± 19 |
Glutamate | 829 ± 687 |
Choline | 8500 |
Binding affinity (human receptors) | |
Receptor | Ki (nanomoles) |
Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John's wort.[14] It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate, with IC50 values of 0.05-0.10 μg/mL for all compounds, with the exception of glutamate, which is in the 0.5 μg/mL range.[15] Hyperforin also inhibits the reuptake of glycine[16] and choline (IC50=8.5μM).[17] It also modulates acetylcholine release in rat hippocampus and facilitates acetylcholine release in the striatum.[18][19] It appears to exert these effects by activating the transient receptor potential ion channel TRPC6.[20] Activation of TRPC6 induces the entry of sodium and calcium into the cell which causes inhibition of monoamine reuptake.[20] It also antagonises the NMDA receptor, AMPA receptor and GABA receptors.[21][22]
Its action on TRPC6 may enable it to protect from ischaemic brain injury.[23] Its action on the TRPC6 cation channel is also believed to be responsible for its BDNF-like modulation of dendritic spine morphology in hippocampal pyramidal neurons.[24]
Hyperforin also induces cytochrome P450 enzymes CYP3A4 and CYP2C9 by binding to and activating the pregnane X receptor (PXR).[25] The induction of CYP3A caused by hypericum perforatum seems to be heavily dependent on its hyperforin content.[26]
Hyperforin has been found to be a potent inhibitor of COX-1 and 5-LO with IC50 values of 300nM and 90nM respectively, giving it an anti-inflammatory action of approximately 3-18 times stronger than aspirin (although it is taken in far lesser quantities).[27]
Hyperforin has topical antibiotic properties and is active against methicillin-resistant strains of Staphylococcus aureus (MRSA) with a minimal inhibitory concentration (MIC) value of 1.0 μg/mL (1.86μM),[28] as well as against other gram-positive bacteria.[29] Chemical analogues of hyperforin have also exhibited in vitro activity against various bacterial species.[30] Hyperforin also has in vitro antimalarial effects.[31]
Procognitive effects of hyperforin have been observed in rats.[12] In vivo evidence suggests its efficacy against Alzheimer's disease,[21][32] an action it seems to share with its analogue, tetrahydrohyperforin.[33][34][35]
Hyperforin also has anticancer effects, both in vitro and in vivo, which are likely the result of its both anti-angiogenic and pro-apoptotic effects.[36] Several chemical analogues of hyperforin have also exhibited anticancer effects in vitro and in vivo.[37][38][39] Hyperforin also has anticlastogenic effects.[40] Hyperforin also inhibits SIRT1 and SIRT2 with a IC50 of 15±0.5μM and 28±0.2μM respectively.[41]
In 2008 it was reported that men with premature ejaculation that were administered an immediate-release oral formulation reported lasting longer.[42] Hyperforin promotes mitochondrial function and the development of oligodendrocytes.[43]
Hyperforin and its semi-synthetic analogues | |||
See also[edit]
Further reading[edit]
- Beerhues L (October 2006). "Molecule of Interest: Hyperforin". Phytochemistry 67 (20): 2201–7. doi:10.1016/j.phytochem.2006.08.017. PMID 16973193.
- pubchem.ncbi.nlm.nih.gov
- ^ https://www.liebertpub.com/DContent/Files/SampleChapters/Sample_BotanicalMedicineFromBenchtoBeds.pdf
- ^ Roz N, Rehavi M. (Jun 2003). "Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane.". Life Sciences 73 (4): 461–70. doi:10.1016/s0024-3205(03)00295-9. PMID 12759140.
- ^ Beerhues L. (2006). "Hyperforin." Phytochemistry 67 (20): 2201-7. PMID 16973193
- ^ Smelcerovic A, Spiteller M (March 2006). "Phytochemical analysis of nine Hypericum L. species from Serbia and the F.Y.R. Macedonia". Die Pharmazie 61 (3): 251–2. PMID 16599273.
- ^ Bystrov NS, Gupta ShR, Dobrynin VN, Kolosov MN, Chernov BK (January 1976). "[Structure of the antibiotic hyperforin]". Doklady Akademii Nauk SSSR (in Russian) 226 (1): 88–90. PMID 1248360.
- ^ Bystrov NS, Chernov BK, Dobrynin VN, Kolosov MN (1975). "[The structure of hyperforin]". Tetrahedron Letters 16 (32): 2791–2794. doi:10.1016/S0040-4039(00)75241-5.
- ^ Shimizu Y, Shi S-L, Usuda H, Kanai M, Shibasaki M (February 2010). "Catalytic Asymmetric Total Synthesis of ent-Hyperforin". Angew Chem Int Ed 49 (6): 1103–6. doi:10.1002/anie.200906678.
- ^ Sparling B, Moebius D, Shair M (December 2012). "Enantioselective Total Synthesis of Hyperforin". J Am Chem Soc 135 (2): 644–7. doi:10.1021/ja312150d. PMID 23270309.
- ^ Liu, F; Pan, C; Drumm, P; Ang, CY (February 2005). "Liquid chromatography-mass spectrometry studies of St. John's wort methanol extraction: active constituents and their transformation". Journal of pharmaceutical and biomedical analysis 37 (2): 303–12. doi:10.1016/j.jpba.2004.10.034. PMID 15708671.
- ^ Biber, A; Fischer, H; Römer, A; Chatterjee, SS (June 1998). "Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers". Pharmacopsychiatry 31 (Suppl 1): 36–43. doi:10.1055/s-2007-979344. PMID 9684946.
- ^ Schulz, HU; Schürer, M; Bässler, D; Weiser, D (2005). "Investigation of the Bioavailability of Hypericin, Pseudohypericin, Hyperforin and the Flavonoids Quercetin and Isorhamnetin Following Single and Multiple Oral Dosing of a Hypericum Extract Containing Tablet". Arzneimittelforschung 55 (1): 15–22. doi:10.1055/s-0031-1296820. PMID 15727160.
- ^ a b Zanoli, P (Fall 2004). "Role of hyperforin in the pharmacological activities of St. John's Wort" (PDF). CNS Drugs Reviews 10 (3): 203–218. doi:10.1111/j.1527-3458.2004.tb00022.x. PMID 15492771.
- ^ "Hyperforin". BindingDB. Retrieved 5 March 2015.
- ^ Newall, Carol A.; Joanne Barnes; Anderson, Linda R. (2002). Herbal medicines: a guide for healthcare professionals. London: Pharmaceutical Press. ISBN 0-85369-474-5.
- ^ Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE (1998). "Hyperforin as a possible antidepressant component of hypericum extracts". Life Sci. 63 (6): 499–510. doi:10.1016/S0024-3205(98)00299-9. PMID 9718074.
- ^ Marsh WL, Davies JA (October 2002). "The involvement of sodium and calcium ions in the release of amino acid neurotransmitters from mouse cortical slices elicited by hyperforin". Life Sciences 71 (22): 2645–55. doi:10.1016/S0024-3205(02)02104-5. PMID 12354583.
- ^ Buchholzer ML, Dvorak C, Chatterjee SS, Klein J (May 2002). "Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort". The Journal of Pharmacology and Experimental Therapeutics 301 (2): 714–9. doi:10.1124/jpet.301.2.714. PMID 11961077.
- ^ Buchholzer, ML; Dvorak, C; Chatterjee, SS; Klein, J (May 2002). "Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort" (PDF). The Journal of Pharmacology and Experimental Therapeutics 301 (2): 714–719. doi:10.1124/jpet.301.2.714. PMID 11961077.
- ^ Kiewert, C; Buchholzer, ML; Hartmann, J; Chatterjee, SS; Klein, J (July 2004). "Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John's Wort". Neuroscience Letters 364 (3): 195–198. doi:10.1016/j.neulet.2004.04.046. PMID 15196674.
- ^ a b Leuner K, Kazanski V, Müller M et al. (December 2007). "Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 (14): 4101–11. doi:10.1096/fj.07-8110com. PMID 17666455.
- ^ a b Griffith, TN; Varela-Nallar, L; Dinamarca, MC; Inestrosa, NC (2010). "Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy". Current Medicinal Chemistry 17 (5): 391–406. doi:10.2174/092986710790226156. PMID 20015041.
- ^ Medina, MA; Martínez-Poveda, B; Amores-Sánchez, MI; Quesada, AR (June 2006). "Hyperforin: More than an antidepressant bioactive compound?". Life Sciences 79 (2): 105–111. doi:10.1016/j.lfs.2005.12.027.
- ^ Lin, Y; Zhang, JC; Fu, J; Chen, F; Wang, J; Wu, ZL; Yuan, SY (February 2013). "Hyperforin attenuates brain damage induced by transient middle cerebral artery occlusion (MCAO) in rats via inhibition of TRPC6 channels degradation". Journal of Cerebral Blood Flow and Metabolism 33 (2): 253–262. doi:10.1038/jcbfm.2012.164. PMID 23149561.
- ^ Leuner, K; Li, W; Amaral, MD; Rudolph, S; Calfa, G; Schuwald, AM; Harteneck, C; Inoue, T; Pozzo-Miller, L. "Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels". Hippocampus 23 (1): 40–52. doi:10.1002/hipo.22052. PMC 3538039. PMID 22815087.
- ^ Moore LB, Goodwin B, Jones SA et al. (June 2000). "St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor". Proceedings of the National Academy of Sciences of the United States of America 97 (13): 7500–2. doi:10.1073/pnas.130155097. PMC 16574. PMID 10852961.
- ^ Mueller, SC; Majcher-Peszynska, J; Mundkowski, RG; Uehleke, B; Klammt, S; Sievers, H; Lehnfeld, R; Frank, B; Thurow, K; Kundt, G; Drewelow, B (January 2009). "No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers" (PDF). European Journal of Clinical Pharmacology 65 (1): 81–87. doi:10.1007/s00228-008-0554-y. PMID 18762932.
- ^ Albert, D; Zündorf, I; Dingermann, T; Müller, WE; Steinhilber, D; Werz, O (December 2002). "Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase". Biochemical Pharmacology 64 (12): 1767–1775. doi:10.1016/S0006-2952(02)01387-4. PMID 12445866.
- ^ Reichling, J; Weseler, A; Saller, R (July 2001). "A current review of the antimicrobial activity of Hypericum perforatum L". Pharmacopsychiatry. 34 Suppl 1: S116–8. doi:10.1055/s-2001-15514. PMID 11518059.
- ^ Schempp, CM; Pelz, K; Wittmer, A; Schöpf, E; Simon, JC (June 1999). "Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria". Lancet 353 (9170): 2129. doi:10.1016/S0140-6736(99)00214-7. PMID 10382704.
- ^ Schiavone, BI; Rosato, A; Marilena, M; Gibbons, S; Bombardelli, E; Verotta, L; Franchini, C; Corbo, F (September 2013). "Biological Evaluation of Hyperforin and Its Hydrogenated Analogue on Bacterial Growth and Biofilm Production" 76 (9). pp. 1819–1823. doi:10.1021/np400394c. PMID 23981190.
- ^ Verotta, L; Appendino, G; Bombardelli, E; Brun, R (March 2007). "In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure–activity study". Bioorganic & Medicinal Chemistry Letters 17 (6): 1544–1548. doi:10.1016/j.bmcl.2006.12.100. PMID 17234416.
- ^ Dinamarca, MC; Cerpa, W; Garrido, J; Hancke, JL; Inestrosa, NC (November 2006). "Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits" (PDF). Molecular Psychiatry 11 (11): 1032–1048. doi:10.1038/sj.mp.4001866. PMID 16880827.
- ^ Carvajal, FJ; Zolezzi, JM; Tapia-Rojas, C; Godoy, JA; Inestrosa, NC (January 2013). "Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-β plaques, 4-hydroxynonenal formation, and caspase-3 activation in AβPP/PS1 mice". Journal of Alzheimer's Disease 36 (1): 99–118. doi:10.3233/JAD-130230. PMID 23568104.
- ^ Cerpa, W; Hancke, JL; Morazzoni, P; Bombardelli, E; Riva, A; Marin, PP; Inestrosa, NC (March 2010). "The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model". Current Alzheimer Research 7 (2): 126–133. doi:10.2174/156720510790691218. PMID 19939230.
- ^ Carvajal, FJ; Inestrosa, NC (September 2011). "Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706" (PDF). Frontiers in Molecular Neuroscience 4: 19. doi:10.3389/fnmol.2011.00019. PMC 3172730. PMID 21949501.
- ^ Quiney, C; Billard, C; Salanoubat, C; Fourneron, JD; Kolb, JP (September 2006). "Hyperforin, a new lead compound against the progression of cancer and leukemia?" (PDF). Leukemia 20 (9): 1519–1525. doi:10.1038/sj.leu.2404301. PMID 16791262.
- ^ Martínez-Poveda, B; Verotta, L; Bombardelli, E; Quesada, AR; Medina, MA (March 2010). "Tetrahydrohyperforin and Octahydrohyperforin Are Two New Potent Inhibitors of Angiogenesis" (PDF). PLoS ONE 5 (3): e9558. doi:10.1371/journal.pone.0009558. PMC 2835552. PMID 20224821.
- ^ Sun, F; Liu, JY; He, F; Liu, Z; Wang, R; Wang, DM; Wang, YF; Yang, DP (August 2011). "In-vitro antitumor activity evaluation of hyperforin derivatives". Journal of Asian Natural Products Research 13 (8): 688–699. doi:10.1080/10286020.2011.584532. PMID 21751836.
- ^ Gartner, M; Müller, T; Simon, JC; Giannis, A; Sleeman, JP (January 2005). "Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent". Chembiochem 6 (1): 171–177. doi:10.1002/cbic.200400195. PMID 15593112.
- ^ Imreova, P; Miadokova, C; Galova, E; Chankova, S; Chalupa, I. "POTENTIAL ANTICLASTOGENIC EFFECT OF HYPERFORIN" (PDF). Military Medical Science Letters 82: 1–5. ISSN 0372-7025.
- ^ Gey, C; Kyrylenko, S; Hennig, L; Nguyen, LH; Büttner, A; Pham, HD; Giannis, A (July 2, 2007). "Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2". Angewandte Chemie International Edition 46 (27): 5219–5222. doi:10.1002/anie.200605207. PMID 17516596.
- ^ Kim, DK; Chancellor, MB (May–June 2008). "Men reporting lasting longer with hyperforin" (PDF). International Braz J Urol 34 (3): 370–371. doi:10.1590/S1677-55382008000300017. PMID 18601770.
- ^ Wang, Y; Zhang, Y; He, J; Zhang, H; Xiao, L; Nazarali, A; Zhang, Z; Zhang, D; Tan, Q; Kong, J; Li, XM (November 2011). "Hyperforin promotes mitochondrial function and development of oligodendrocytes" (PDF). Journal of Neurochemistry 119 (3): 555–568. doi:10.1111/j.1471-4159.2011.07433.x. PMID 21848657.
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A TCF Bank.
TCF Financial recently reported fourth-quarter earnings of 15 cents per share that were below analysts' expectations of 18 cents per share.
Stephen Geyen, an analyst for Stifel Nicolaus, had a "buy" recommendation on TCF since at least March 2012 and a target price of $13 per share since July. On Thursday, Geyen downgraded TCF to "hold."
But the downgrade was more for the stock's recent run-up in price rather than for the earnings miss, which was partly attributed to some one-time non-core expenses, including a recent $10 million civil penalty. "Following the recent run-up in the share price, TCB stock now trades essentially in line with our fair value estimate of around $13," wrote Geyen. TCB shares closed Friday at $13.78.
Piper Jaffray's shares moved higher last week after the company reported strong fourth-quarter and year-end financials. "The company's performance has been definitely spotty in recent years," Michael Wong, an analyst at Morningstar, recently told the Star Tribune. "They have cleaned up their businesses and seem to be heading in the right direction."