text:
New Drug May Slow MS Progression »
"April 12, 2011 -- The experimental oral multiple sclerosis (MS) drug laquinimod delayed disease progression, reduced relapse rates, and was safe and well tolerated by patients in a two-year study.
Details of the study were announced M"...
Mechanism Of Action
Fingolimod is metabolized by sphingosine kinase to the active metabolite, fingolimod-phosphate. Fingolimod-phosphate is a sphingosine 1-phosphate receptor modulator, and binds with high affinity to sphingosine 1-phosphate receptors 1, 3, 4, and 5. Fingolimod-phosphate blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. The mechanism by which fingolimod exerts therapeutic effects in multiple sclerosis is unknown, but may involve reduction of lymphocyte migration into the central nervous system.
Heart Rate and Rhythm
Fingolimod causes a transient reduction in heart rate and AV conduction at treatment initiation [see WARNINGS AND PRECAUTIONS].
Heart rate progressively increases after the first day, returning to baseline values within 1 month of the start of chronic treatment.
Autonomic responses of the heart, including diurnal variation of heart rate and response to exercise, are not affected by fingolimod treatment.
Fingolimod treatment is not associated with a decrease in cardiac output.
Potential to Prolong the QT Interval
In a thorough QT interval study of doses of 1.25 or 2.5 mg fingolimod at steady-state, when a negative chronotropic effect of fingolimod was still present, fingolimod treatment resulted in a prolongation of QTc, with the upper bound of the 90% confidence interval (CI) of 14.0 msec. There is no consistent signal of increased incidence of QTc outliers, either absolute or change from baseline, associated with fingolimod treatment. In MS studies, there was no clinically relevant prolongation of QT interval, but patients at risk for QT prolongation were not included in clinical studies.
Immune System
Effects on Immune Cell Numbers in the Blood
In a study in which 12 subjects received GILENYA 0.5 mg daily, the lymphocyte count decreased to approximately 60% of baseline within 4-6 hours after the first dose. With continued daily dosing, the lymphocyte count continued to decrease over a 2-week period, reaching a nadir count of approximately 500 cells/μL or approximately 30% of baseline. In a placebo-controlled study in 1272 MS patients (of whom 425 received fingolimod 0.5 mg daily and 418 received placebo), 18% (N=78) of patients on fingolimod 0.5 mg reached a nadir of < 200 cells/μL on at least 1 occasion. No patient on placebo reached a nadir of < 200 cells/μL. Low lymphocyte counts are maintained with chronic daily dosing of GILENYA 0.5 mg daily.
Chronic fingolimod dosing leads to a mild decrease in the neutrophil count to approximately 80% of baseline. Monocytes are unaffected by fingolimod.
Peripheral lymphocyte count increases are evident within days of stopping fingolimod treatment and typically normal counts are reached within 1 to 2 months.
Effect on Antibody Response
GILENYA reduces the immune response to vaccination, as evaluated in 2 studies.
In the first study, the immunogenicity of keyhole limpet hemocyanin (KLH) and pneumococcal polysaccharide vaccine (PPV-23) immunization were assessed by IgM and IgG titers in a steady-state, randomized, placebo-controlled study in healthy volunteers. Compared to placebo, antigen-specific IgM titers were decreased by 91% and 25% in response to KLH and PPV-23, respectively, in subjects on GILENYA 0.5 mg. Similarly, IgG titers were decreased by 45% and 50%, in response to KLH and PPV-23, respectively, in subjects on GILENYA 0.5 mg daily compared to placebo. The responder rate for GILENYA 0.5 mg as measured by the number of subjects with a > 4-fold increase in KLH IgG was comparable to placebo and 25% lower for PPV-23 IgG, while the number of subjects with a > 4 fold increase in KLH and PPV-23 IgM was 75% and 40% lower, respectively, compared to placebo. The capacity to mount a skin delayed-type hypersensitivity reaction to Candida and tetanus toxoid was decreased by approximately 30% in subjects on GILENYA 0.5 mg daily, compared to placebo. Immunologic responses were further decreased with fingolimod 1.25 mg (a dose higher than recommended in MS) [see WARNINGS AND PRECAUTIONS].
In the second study, the immunogenicity of Northern hemisphere seasonal influenza and tetanus toxoid vaccination was assessed in a 12-week steady-state, randomized, placebo-controlled study of GILENYA 0.5 mg in multiple sclerosis patients (n=136). The responder rate 3 weeks after vaccination, defined as seroconversion or a ≥ 4-fold increase in antibody directed against at least 1 of the 3 influenza strains, was 54% for GILENYA 0.5 mg and 85% in the placebo group. The responder rate 3 weeks after vaccination, defined as seroconversion or a ≥ 4-fold increase in antibody directed against tetanus toxoid was 40% for GILENYA 0.5 mg and 61% in the placebo group.
Pulmonary Function
Single fingolimod doses ≥ 5 mg (10-fold the recommended dose) are associated with a dose-dependent increase in airway resistance. In a 14-day study of 0.5, 1.25, or 5 mg/day, fingolimod was not associated with impaired oxygenation or oxygen desaturation with exercise or an increase in airway responsiveness to methacholine. Subjects on fingolimod treatment had a normal bronchodilator response to inhaled beta-agonists.
In a 14-day placebo-controlled study of patients with moderate asthma, no effect was seen for GILENYA 0.5 mg (recommended dose in MS). A 10% reduction in mean FEV1 at 6 hours after dosing was observed in patients receiving fingolimod 1.25 mg (a dose higher than recommended for use in MS) on Day 10 of treatment. Fingolimod 1.25 mg was associated with a 5-fold increase in the use of rescue short acting beta-agonists.
The Tmax of fingolimod is 12-16 hours. The apparent absolute oral bioavailability is 93%.
Food intake does not alter C max or exposure (AUC) of fingolimod or fingolimod-phosphate. Therefore GILENYA may be taken without regard to meals.
Steady-state blood concentrations are reached within 1 to 2 months following once-daily administration and steady-state levels are approximately 10-fold greater than with the initial dose.
Fingolimod highly (86%) distributes in red blood cells. Fingolimod-phosphate has a smaller uptake in blood cells of < 17%. Fingolimod and fingolimod-phosphate are > 99.7% protein bound. Fingolimod and fingolimod-phosphate protein binding is not altered by renal or hepatic impairment.
Fingolimod is extensively distributed to body tissues with a volume of distribution of about 1200±260 L.
The biotransformation of fingolimod in humans occurs by 3 main pathways: by reversible stereoselective phosphorylation to the pharmacologically active (S)-enantiomer of fingolimod-phosphate, by oxidative biotransformation mainly via the cytochrome P450 4F2 isoenzyme and subsequent fatty acid-like degradation to inactive metabolites, and by formation of pharmacologically inactive non-polar ceramide analogs of fingolimod.
Fingolimod is primarily metabolized via human CYP4F2 with a minor contribution of CYP2D6, 2E1, 3A4, and 4F12. Inhibitors or inducers of these isozymes might alter the exposure of fingolimod or fingolimod-phosphate. The involvement of multiple CYP isoenzymes in the oxidation of fingolimod suggests that the metabolism of fingolimod will not be subject to substantial inhibition in the presence of an inhibitor of a single specific CYP isozyme.
Following single oral administration of [14C] fingolimod, the major fingolimod-related components in blood, as judged from their contribution to the AUC up to 816 hours post-dose of total radiolabeled components, are fingolimod itself (23.3%), fingolimod-phosphate (10.3%), and inactive metabolites [M3 carboxylic acid metabolite (8.3%), M29 ceramide metabolite (8.9%), and M30 ceramide metabolite (7.3%)].
Fingolimod blood clearance is 6.3±2.3 L/h, and the average apparent terminal half-life (t ½ ) is 6 to 9 days. Blood levels of fingolimod-phosphate decline in parallel with those of fingolimod in the terminal phase, yielding similar half-lives for both.
After oral administration, about 81% of the dose is slowly excreted in the urine as inactive metabolites. Fingolimod and fingolimod-phosphate are not excreted intact in urine but are the major components in the feces with amounts of each representing less than 2.5% of the dose.
Special Populations
Renal Impairment
In patients with severe renal impairment, fingolimod C max and AUC are increased by 32% and 43%, respectively, and fingolimod-phosphate Cmax and AUC are increased by 25% and 14%, respectively, with no change in apparent elimination half-life. Based on these findings, the GILENYA 0.5 mg dose is appropriate for use in patients with renal impairment. The systemic exposure of 2 metabolites (M2 and M3) is increased by 3-and 13-fold, respectively. The toxicity of these metabolites has not been fully characterized.
A study in patients with mild or moderate renal impairment has not been conducted.
Hepatic Impairment
In subjects with mild, moderate, or severe hepatic impairment, no change in fingolimod C max was observed, but fingolimod AUC was increased respectively by 12%, 44%, and 103%. In patients with severe hepatic impairment, fingolimod-phosphate C max was decreased by 22% and AUC was not substantially changed. The pharmacokinetics of fingolimod-phosphate was not evaluated in patients with mild or moderate hepatic impairment. The apparent elimination half-life of fingolimod is unchanged in subjects with mild hepatic impairment, but is prolonged by about 50% in patients with moderate or severe hepatic impairment.
Patients with severe hepatic impairment should be closely monitored, as the risk of adverse reactions is greater [see WARNINGS AND PRECAUTIONS].
No dose adjustment is needed in patients with mild or moderate hepatic impairment.
The effects of race on fingolimod and fingolimod-phosphate pharmacokinetics cannot be adequately assessed due to a low number of non-white patients in the clinical program.
Gender has no clinically significant influence on fingolimod and fingolimod-phosphate pharmacokinetics.
Geriatric Patients
The mechanism for elimination and results from population pharmacokinetics suggest that dose adjustment would not be necessary in elderly patients. However, clinical experience in patients aged above 65 years is limited.
Pharmacokinetic Interactions
The coadministration of ketoconazole (a potent inhibitor of CYP3A and CYP4F) 200 mg twice daily at steady-state and a single dose of fingolimod 5 mg led to a 70% increase in AUC of fingolimod and fingolimod-phosphate. Patients who use GILENYA and systemic ketoconazole concomitantly should be closely monitored, as the risk of adverse reactions is greater [see DRUG INTERACTIONS].
The coadministration of carbamazepine (a potent CYP450 enzyme inducer) 600 mg twice daily at steady-state and a single dose of fingolimod 2 mg decreased blood concentrations (AUC) of fingolimod and fingolimod-phosphate by approximately 40%. The clinical impact of this decrease is unknown.
Other strong CYP450 enzyme inducers, e.g., rifampicin, phenytoin, phenobarbital, and St. John's wort, may also reduce AUC of fingolimod and fingolimod-phosphate. The clinical impact of this potential decrease is unknown.
Potential of Fingolimod and Fingolimod-phosphate to Inhibit the Metabolism of Comedications
In vitro inhibition studies in pooled human liver microsomes and specific metabolic probe substrates demonstrate that fingolimod has little or no capacity to inhibit the activity of the following CYP450 enzymes: CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4/5, or CYP4A9/11, and similarly fingolimodphosphate has little or no capacity to inhibit the activity of CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 at concentrations up to 3 orders of magnitude of therapeutic concentrations. Therefore, fingolimod and fingolimod-phosphate are unlikely to reduce the clearance of drugs that are mainly cleared through metabolism by the major cytochrome P450 isoenzymes described above.
Potential of Fingolimod and Fingolimod-phosphate to Induce its Own and/or the Metabolism of Comedications
Fingolimod was examined for its potential to induce human CYP3A4, CYP1A2, CYP4F2, and MDR1 (P-glycoprotein) mRNA and CYP3A, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP4F2 activity in primary human hepatocytes. Fingolimod did not induce mRNA or activity of the different CYP450 enzymes and MDR1 with respect to the vehicle control; therefore, no clinically relevant induction of the tested CYP450 enzymes or MDR1 by fingolimod are expected at therapeutic concentrations. Fingolimod-phosphate was also examined for its potential to induce mRNA and/or activity of human CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A, CYP4F2, CYP4F3B, and CYP4F12. Fingolimod-phosphate is not expected to have clinically significant induction effects on these enzymes at therapeutic dose of fingolimod.
Fingolimod as well as fingolimod-phosphate are not expected to inhibit the uptake of comedications and/or biologics transported by OATP1B1, OATP1B3, or NTCP. Similarly, they are not expected to inhibit the efflux of comedications and/or biologics transported by the breast cancer resistant protein (MXR), the bile salt export pump (BSEP), the multidrug resistance-associated protein 2 (MRP2), and MDR1-mediated transport at therapeutic concentrations.
Oral Contraceptives
The coadministration of fingolimod 0.5 mg daily with oral contraceptives (ethinylestradiol and levonorgestrel) did not elicit any clinically significant change in oral contraceptives exposure. Fingolimod and fingolimod-phosphate exposure were consistent with those from previous studies. No interaction studies have been performed with oral contraceptives containing other progestagens; however, an effect of fingolimod on their exposure is not expected.
The pharmacokinetics of single-dose fingolimod was not altered during coadministration with cyclosporine at steady-state, nor was cyclosporine steady-state pharmacokinetics altered by fingolimod. These data indicate that GILENYA is unlikely to reduce the clearance of drugs mainly cleared by CYP3A4 and show that the potent inhibition of transporters MDR1, MRP2, and OATP-C does not influence fingolimod disposition.
Isoproterenol, Atropine, Atenolol, and Diltiazem
Single-dose fingolimod and fingolimod-phosphate exposure was not altered by coadministered isoproterenol or atropine. Likewise, the single-dose pharmacokinetics of fingolimod and fingolimod-phosphate and the steady-state pharmacokinetics of both atenolol and diltiazem were unchanged during the coadministration of the latter 2 drugs individually with fingolimod.
Population Pharmacokinetics Analysis
A population pharmacokinetics evaluation performed in MS patients did not provide evidence for a significant effect of fluoxetine and paroxetine (strong CYP2D6 inhibitors) on fingolimod or fingolimod-phosphate predose concentrations. In addition, the following commonly coprescribed substances had no clinically relevant effect ( < 20%) on fingolimod or fingolimod-phosphate predose concentrations: baclofen, gabapentin, oxybutynin, amantadine, modafinil, amitriptyline, pregabalin, and corticosteroids.
Animal Toxicology And/Or Pharmacology
Lung toxicity was observed in 2 different strains of rats and in dogs and monkeys. The primary findings included increase in lung weight, associated with smooth muscle hypertrophy, hyperdistension of the alveoli, and/or increased collagen. Insufficient or lack of pulmonary collapse at necropsy, generally correlated with microscopic changes, was observed in all species. In rats and monkeys, lung toxicity was observed at all oral doses tested in chronic studies. The lowest doses tested in rats (0.05 mg/kg/day in the 2-year carcinogenicity study) and monkeys (0.5 mg/kg/day in the 39-week toxicity study) are similar to and approximately 20 times the RHD on a mg/m² basis, respectively.
In the 52-week oral study in monkeys, respiratory distress associated with ketamine administration was observed at doses of 3 and 10 mg/kg/day; the most affected animal became hypoxic and required oxygenation. As ketamine is not generally associated with respiratory depression, this effect was attributed to fingolimod. In a subsequent study in rats, ketamine was shown to potentiate the bronchoconstrictive effects of fingolimod. The relevance of these findings to humans is unknown.
Clinical Studies
The efficacy of GILENYA was demonstrated in 2 studies that evaluated once-daily doses of GILENYA 0.5 mg and 1.25 mg in patients with relapsing-remitting MS (RRMS). Both studies included patients who had experienced at least 2 clinical relapses during the 2 years prior to randomization or at least 1 clinical relapse during the 1 year prior to randomization, and had an Expanded Disability Status Scale (EDSS) score from 0 to 5.5. Study 1 was a 2-year randomized, double-blind, placebo-controlled study in patients with RRMS who had not received any interferon-beta or glatiramer acetate for at least the previous 3 months and had not received any natalizumab for at least the previous 6 months. Neurological evaluations were performed at screening, every 3 months and at time of suspected relapse. MRI evaluations were performed at screening, Month 6, Month 12, and Month 24. The primary endpoint was the annualized relapse rate.
Median age was 37 years, median disease duration was 6.7 years and median EDSS score at baseline was 2.0. Patients were randomized to receive GILENYA 0.5 mg (N=425), 1.25 mg (n=429), or placebo (N=418) for up to 24 months. Median time on study drug was 717 days on 0.5 mg, 715 days on 1.25 mg and 719 days on placebo.
The annualized relapse rate was significantly lower in patients treated with GILENYA than in patients who received placebo. The secondary endpoint was the time to 3-month confirmed disability progression as measured by at least a 1 point increase from baseline in EDSS (0.5 point increase for patients with baseline EDSS of 5.5) sustained for 3 months. Time to onset of 3-month confirmed disability progression was significantly delayed with GILENYA treatment compared to placebo. The 1.25 mg dose resulted in no additional benefit over the GILENYA 0.5 mg dose. The results for this study are shown in Table 2 and Figure 1.
Table 2 : Clinical and MRI
Results of Study 1
GILENYA 0.5 mg N=425 |
Placebo N=418 |
p-value | |
Clinical Endpoints | |||
Annualized relapse rate (primary endpoint) | 0.18 | 0.4 | < 0.001 |
Percentage of patients without relapse | 70% | 46% | < 0.001 |
Hazard ratio‡ of disability progression (95% CI) | 0.70 (0.52, 0.96) | 0.02 | |
MRI Endpoint | |||
Mean (median) number of new or newly enlarging T2 lesions over 24 months | 2.5 (0) | 9.8 (5.0) | < 0.001 |
Mean (median) number of T1 Gd-enhancing lesions | 0.2 (0) | 1.1 (0) | < 0.001 |
All analyses of clinical
endpoints were intent-to–treat. MRI analysis used evaluable dataset. ‡ Hazard ratio is an estimate of the relative risk of having the event of disability progression on GILENYA as compared to placebo. |
Figure 1 : Time to 3-month
Confirmed Disability Progression – Study 1 (ITT population)
Study 2 was a 1-year randomized, double-blind, double-dummy, active-controlled study in patients with RRMS who had not received any natalizumab in the previous 6 months. Prior therapy with interferon-beta or glatiramer acetate up to the time of randomization was permitted.
Neurological evaluations were performed at screening, every 3 months, and at the time of suspected relapses. MRI evaluations were performed at screening and at month 12. The primary endpoint was the annualized relapse rate.
Median age was 36 years, median disease duration was 5.9 years, and median EDSS score at baseline was 2.0. Patients were randomized to receive GILENYA 0.5 mg (N=431), 1.25 mg (n=426), or interferon beta-1a, 30 micrograms via the intramuscular route (IM) once weekly (N=435) for up to 12 months. Median time on study drug was 365 days on GILENYA 0.5 mg, 354 days on 1.25 mg, and 361 days on interferon beta-1a IM.
The annualized relapse rate was significantly lower in patients treated with GILENYA 0.5 mg than in patients who received interferon beta-1a IM. The key secondary endpoints were number of new and newly enlarging T2 lesions and time to onset of 3-month confirmed disability progression as measured by at least a 1-point increase from baseline in EDSS (0.5 point increase for those with baseline EDSS of 5.5) sustained for 3 months. The number of new and newly enlarging T2 lesions was significantly lower in patients treated with GILENYA than in patients who received interferon beta-1a IM. There was no significant difference in the time to 3-month confirmed disability progression between GILENYA and interferon beta-1a-treated patients at 1 year. The 1.25 mg dose resulted in no additional benefit over the GILENYA 0.5 mg dose. The results for this study are shown in Table 3.
Table 3 : Clinical and MRI
Results of Study 2
GILENYA 0.5 mg N=429 |
Interferon beta-1a IM 30μg N=431 |
p-value | |
Clinical Endpoints | |||
Annualized relapse rate (primary endpoint) | 0.16 | 0.33 | < 0.001 |
Percentage of patients without relapse | 83% | 70% | < 0.001 |
Hazard ratio‡ of disability progression (95% CI) | 0.71 (0.42, 1.21) | 0.21 | |
MRI Endpoint | |||
Mean (median) number of new or newly enlarging T2 lesions over 12 months | 1.6 (0) | 2.6 (1.0) | 0.002 |
Mean (median) number of T1 Gd-enhancing lesions | 0.2 (0) | 0.5 (0) | < 0.001 |
‡ Hazard ratio is an estimate of the relative risk of having the event of disability progression on GILENYA as compared to control. |
Pooled results of study 1 and study 2 showed a consistent and statistically significant reduction of annualized relapse rate compared to comparator in subgroups defined by gender, age, prior MS therapy, and disease activity.
Last reviewed on RxList: 5/20/2014
This monograph has been modified to include the generic and brand name in many instances.
Gilenya FDA Prescribing Information
Additional Gilenya Information
Gilenya - User Reviews
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Multiple Sclerosis
Get the latest treatment options.


text:
The new YOU begins today!
Discover how
a Roman Chair provides these RESULTS...
Core Power |
Beautiful Curves |
Pain Relief |
Most Popular |
Great Value |
$349 |
$269 |
Get Ripped... Trim Inches... Feel Good Again!
Here's the story: "Without a doubt... a roman-chairis the SECRET to explosive power, beautiful curves, and feeling good." |
Dr. Knudsen, Owner of a Provo Physical Therapy Clinic |
Need A Beach-Ready Body? |
To Beautiful Curves |
Got Back Pain? |
Discover What It's Like |
Want Rock-Hard Core Muscles? |
To Crush The Competition |
I decided to get the 45/90 degree roman chair by Bodycraft.
"After spending time researching the excellent information on your site... I chose the 45/90. I liked the idea of being able to progress from the easier (45 degree) workout angle to the more difficult (90 degree). I found the thigh pad to be extremely comfortable, like I read in Dr. Knudsen's review. I was worried about putting it all together, but the instructions were easy to follow. It only took me about 30 minutes to put together."
Wendy S. - Tennessee
After careful consideration I chose to buy from your site.
"I noticed that your prices were just as low or lower for the Powertec Dual Hyperextension than all the other web sites, but your information was so much better that I wanted to give you my business.
I felt safer knowing that BackTrainer.com has been around since 1999 and that I could trust that your company would delivery the goods in a timely manner. I was very pleased with your service and I can tell that these roman chair hyperextension exercises are going to build my core muscles.
I can already see a difference... my back and abs are getting ripped already."
Sam F. - Oklahoma
Thanks for the FREE roman chair workout video
and the excellent customer service!
"I watched your bonus video - it helped me to understand how to use my equipment better. Seeing that you have the lowest price, too... it was a "no brainer" to buy from the backtrainer.com web site. Thanks for all the great information and the quick customer service. I was glad to receive the emails that told me when my roman chair would arrive!"
After 13 years of experience selling roman chairs online...
we make the choice simply for you! Choose one of the two roman chairs below and MAKE IT YOURS.
Return to top of page! |

subset: commoncrawl


text:
Fla. Sheriff's Chopper Crashes on Interstate Ramp
FORT PIERCE, Fla. --
A helicopter from the St. Lucie County Sheriff's Office crashed while responding to a rollover wreck on Interstate 95 crashed Sunday.
The aircraft went down on a ramp leading to I-95 at Okeechobee Road in Fort Pierce. Investigators said the pilot was called to search the area to see if anyone in the wreck had been thrown from the vehicle.
The helicopter pilot, Shawn E. Sullivan, was the only one on board. He was taken to Lawnwood Medical Center.
Sheriff Ken J. Mascara said Sullivan was being checked for possible spinal injuries, but the prognosis was encouraging.
"Our latest information is that Deputy Sullivan's injuries are not serious," he said.
The helicopter was damaged in the crash.
The crash has shut down the on-ramp, but northbound I-95 has reopened.
The St. Lucie County Sheriff's Office said it has notified two federal agencies: the Federal Aviation Administration and the National Transportation Safety Board.
Sullivan has been a member of the St. Lucie County Sheriff's Office for one year.
The helicopter that crashed is a Bell OH-58, a U.S. Army surplus helicopter that the Sheriff's Office acquired after paying a small processing fee to the U.S. Army
Copyright 2011 by WPBF.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
ilovethe80s87's review of Aquolina Gold Sugar
25 reviews
64% would repurchase
Package Quality: 3.8
Price: $$
Package Quality: 3.8
Price: $$
Age: 25-29
Skin: Acne-prone, Fair-Medium, Neutral
Hair: Brown, Straight, Fine
Eyes: Hazel
My new favorite perfume right now :) I have so many perfumes and they are all my favorite when I first get them haha, so I'm sure this will be no different.
This is definitely not sugary like Pink Sugar. I don't particularly care for the fruity top notes of citrus-ness. However, beneath those top notes are creamy vanilla dessert and hints of coconut and musk. I hate musky smells, but in this case I admire how it ups the maturity of this fragrance. The sillage isn't so intense as to knock out anyone that comes in the room, but just enough to where the person standing next to you can smell it. And it lasts about 3-5 hours; after about an hour you can really only smell it on yourself, but sometimes that's all one needs :)
I might not repurchase it until it becomes available on some inexpensive perfume website. I got this one basically from taking it out of the gift set I got at Sephora for my brother's girlfriend (which has Pink Sugar edt, body lotion and shower gel, and Gold Sugar edt) and keeping it for myself, shhhhhh :P
Overall nice fragrance if you like rich creamy fragrances.
Read all 25 reviews of Gold Sugar
Popular Fragrances


text:
Re: Compression
Snappy is built into CDH3u1, so if you go that route it's easiest. As
for raw speed, snappy is the fastest, but doesn't have the best compression ratio. There was an earlier thread where some people noted faster HBase performance using gzip compared to snappy. I haven't done my own testing, so it might be worth trying out those two and comparing. -Joey On Wed, Sep 14, 2011 at 11:10 AM, Otis Gospodnetic <[EMAIL PROTECTED]> wrote: > We use lzo, as do some of our customers. We have not tried Snappy yet, but all feedback I ever saw about it was positive. > > Otis > ---- > Sematext :: http://sematext.com/ :: Solr - Lucene - Hadoop - HBase > Hadoop ecosystem search :: http://search-hadoop.com/ > > > >>________________________________ >>From: Wayne <[EMAIL PROTECTED]> >>To: [EMAIL PROTECTED] >>Sent: Wednesday, September 14, 2011 8:33 AM >>Subject: Compression >> >>I wanted to do a poll on what compression libraries people are using and >>why. We currently use lzo but are considering other alternatives for various >>reasons. We would like to move to CDH3 but adding lzo ourselves is a hassle >>we are not looking to take on. It kind of defeats the purpose os using CDH3 >>to begin with. We current run 20.0 append. >> >>I know there are a lot of variables that affect the best decision, but we >>are looking for general trends in the community. >> >>Is lzo still the most recommended? Is there benefit in using the lzo >>professional library and does anyone use this? >>Is snappy just as good as lzo and a lot easier to deal with in term of node >>build/releases? >>Does zlib/gzip have any traction? >> >>Compression ratios are important but as always performance/speed is our >>biggest requirement. What are people using and why? Where is the momentum >>going? Compression is a huge benefit of hadoop/hbase and having high >>compression ratios with solid performance is a major benefit. >> >>Any recommendations would be appreciated. >> >>Thanks. >> >> >> -- Joseph Echeverria Cloudera, Inc. 443.305.9434 |


text:
Results 16 to 20 of 34
Thread: Desert Island Discs
November 2nd, 2013 10:52 PM #16
Ugh, this is so hard! Not for lack of loving things, but for lack of loving them so decidedly! I love a lot of music, and a lot of books, but I can't listen to them over and over and over again, or read them over and over and over again. But I'll give it a go.
1. Marching On (by OneRepublic)
2. One Thing (by One Direction. I know, I know, I know! But they're my one GP. And I think this will always be my favorite song of theirs)
3. [More Time] (by NeedtoBREATHE. Seriously, I'm supposed to choose? I could have made this whole list full of NeedtoBREATHE. Le sigh. This was the only one I could think of, and I loved P.S. I Love You... I love about 20 others, too, though...)
4. Worn (by Tenth Avenue North. Not a lifetime favorite or anything, but I've really been loving it lately...)
5. A Drop in the Ocean (by Ron Pope. I discovered it one summer and played it probably a thousand times that summer. Still stinkin' love it.)
6. Fight (by Lee Dewyze)
7. I Want Crazy (by Hunter Hayes)
8. Home Home Home (by Philip Phillips)
Hardly a genuine representation of my taste in music, but meh. I could have done much better if I could have picked artists rather than songs.
Book: The Chronicles of Narnia (that counts as a book, yes? ) Or The Importance of Being Earnest. Or The Scarlet Pimpernel. Or the O'Malley series, by Dee Henderson. Or Flee the Night, by Susan May Warren. Or My Foolish Heart, by Susan May Warren... Or any book by Julie Klassen... Or... crap. It should have been 8 books and 1 song, not the other way around... I think I'd go with My Foolish Heart... Love Susan May Warren.
Luxury item: My one true love. Does that count? And I feel silly calling him a luxury item. I haven't even found him yet, but I'd rather have nothing but a book, my Bible, Shakespeare, 8 songs, and my true love than any other luxury item out there. If not, then a very, very durable laptop with wifi. So I can write to pass the time, and potentially even get them published one day...Ashley
twenty-something namenerd & aspiring novelist
Isabelle + Arianne + Olivia + Violet + Grace + Emmeline + Charlotte + Eva + Catherine + Eleni + Zoe + Adele + Lilian
Caleb + Everett + Grant + Casper + Samuel + Jack + Avery + Rory + Declan + Zane + Schuyler + Rowan + Judah
I've recently started a new story--feel free to come along with me for the journey! havengermany.blogspot.com
Chapter 1 is up!
November 3rd, 2013 01:29 AM #18
@sessha - we call our bed Cloud Bed, too!
@ottilie - I love Winter! This is the song that I have always held dear to my heart because it makes me think of my dad (and now he cries when I sing it for him, awww)
"Exactly" by Amy Steinberg to remind me to be present and love my life
"Shake It Out" by Florence + The Machine to remind me to stay positive and keep dancing no matter how bad things seem
"Why Walk When You Can Fly" by Mary Chapin Carpenter to remind me to always strive to be extraordinary
"Like A Prayer" by Madonna - one of the most perfect songs in existence and I'll need something to dance to!
"Such Great Heights" by The Postal Service - Another great dance song that always makes me happy
"The Highwayman" by Loreena McKennitt - of of my favorite poems set to gorgeous music
"Take This Waltz" by Leonard Cohen - Gosh, how can I pick just one Leonard Cohen song? But I guess this one is my favorite
"Walking in Memphis" by Marc Cohn - one of my favorite songs
Book: Dangit, that is a hard choice... I have never read the Mahabharata, but I want to, so that's what I'd choose.
Luxury item: I have to agree with Sessha - CLOUDBED!Sequoia Orion born November 2014
Considerations for our next child's name: Cytheria, Caspian, Seraphina, Arcadia, Venture
Middles: Beatrix, Dwyn, Jupiter, Violet, Zephyr, River
November 3rd, 2013 06:13 AM #20~Boys~
★ August Eli Benedict ★ Bram ★ Casimir Mordecai ★ Edmond John Meirion ★ Gillon ★
★ Jory Leander ★ Julian Charles ★ Macsen ★ Magnus ★ Vasiliy ★
★ Aira Rose ★ Arietta ★ Clover ★ Delphina ★ Eleni ★ Fiorella ★ Hester Isobel ★
★ Iris ★ Lilah ★ Merit ★ Sylvia ★
Sorry to anyone who read TSI. First draft was terrible. Second drafting now.
November 3rd, 2013 10:59 AM #22♥ Margaret Mary ♥
20. Name nerd. College sophomore. Identical twin.
★ Elza Josephine ★ Harriet Corliss ★ Ida Rosemary ★ Mary Jessamine ★ Rose Christabel ★ Sarah Margaret ★
★ Asher Benedict ★ Gabriel August ★ James Fletcher ★ John Constantine ★ Noah Alexander ★ Samuel Ernest ★
November 3rd, 2013 02:32 PM #24
You all have have such good and interesting answers. This is seriously tough though.
1. Human of the Year by Regina Spektor. Arguably the song containing Regina's best vocals. Will always be my favourite song in the world, nothing can change that.
2. Wuthering Heights by Kate Bush. Well, Wuthering Heights is my absolute favourite book and a very few people can beat Kate Bush in impressive vocals.
3. l'Hymne à l'Amour by Édith Piaf. This song never fails to make me cry. It's is one of the most beautiful songs ever written and you can just feel Édith's pain in every word of it.
4. Immigrant Song by Karen O, Trent Reznor and Atticus Ross. I love the original, but I hold a slight preference to this phenomenal cover.
5. Jóga by Björk. My favourite Björk song. It's a hauntingly beautiful song and Björk at her finest.
6. Speechless by Lady Gaga. When I encounter people who claim that Gaga can't sing, I always tell them to listen to a live version of Speechless, then look me in the eyes and tell me once more that she can't sing (= isn't possible). Gaga has meant a lot to me over a long period of time. I have seen her live twice and each time she has managed to make me cry heaps. This song is so emotional and different from all of her other songs. I love it.
7. The Party by Regina Spektor. I couldn't resist putting two Regina songs on here. Although I don't think that What We Saw From The Cheap Seats was as insanely brilliant as Far, Begin to Hope and Soviet Kitsch are, this song is just so beautiful and has won my heart completely.
8. Winter Song by Sara Bareilles and Ingrid Michaelson. Probably my favourite collaboration of all time. I love both Sara and Ingrid and this is such a cosy song which has such a strong Christmas feel to it. And I really love Christmas.
Book: Wuthering Heights. However, if you are allowed to bring all seven Harry Potter books (maybe in a huge compiled form, eh?), that will be my choice because I'll never get tired of the way Jo can grab and enchant you with her words.
Luxury Item: My beloved Macbook with either Wi-Fi or one of those portable internet things.Last edited by shvibziks; November 3rd, 2013 at 07:08 PM.
Zelia • Twenty-one • Film and royalty connoisseur • I have a blog and one about royalsExporting old Danish names as well as Greenlandic names and sibling names
Henry Ásgeirr Edmund • Alexander Adelin Lórien "Alyosha" • Amaury Charles Théoden "Theo" • Asa Edouard Ivik
Cosima Ingrid Zenobia "Mimi" • Anna/Matilda Ivalo Galadriel • Asta Catherine Françoise • Anna/Gaia Margaret Undómiel
GPs: Atticus Aksel Inigo • Cosimo James Eärendil "Jem" • Aviaaja Cleopatra Hero "Avi" • Fabiola Agnes Lúthien


text:
Where's My Power?
By Erik Didriksen | Aug 4, 2008
Race name: Tour of Elk Grove Criterium
Race date: Saturday, Feb 2, 2008
- Also by Erik Didriksen:
- » Race reports
- » Race results
- » Report RSS
August 02
Tour of Elk Grove - Elite 4's
Chicago residents are no strangers to traffic, but it was quite a surprise to find the Kennedy at a standstill as we headed out to Elk Grove from the city… so much for a pre-race warmup, we figured. When we arrived, it was clear that this event was as well organized as last year - 40 minutes prior to the start of the first race, barricades and cameras were in place, the finish line was striped, and not to be outdone by Da Mare, Elk Grove had a Jumbotron!
Registration was another story… Race organizers: Pre-registration benefits organizer and racer alike. One of the ways you can make everyone's life easier is to pre-fill USAC waivers on behalf of your participants so the check-in process goes much smoother. You get a legible form, we don't have to scramble to find a decent writing surface. Deal. It took almost 20 minutes to sign my form and get my numbers… and there was no line when I walked up to the table. By the time I walked away, there were at least 10 people waiting.
While changing for the race, the 5's were off and it was strung out from the beginning… I thought it was a preview lap at first, but when I saw the leaders' speeds it was apparent that the 5's were strung out from the beginning. No such luck for us. When we got to the staging area to line up, everyone was antsy - it was getting quite warm out and first race had gotten off a few minutes late. Once the pace car confirmed the course was clear of the previous race, we were told to head to the line, no preview lap. At the line, the referee announced that our race was being cut to 25 minutes + 2 instead of the prescribed 30 minutes + 1. Positioning at the line is critical in this narrow course, so I moved up as far as possible. We started fast, and the group strung out a good bit due to some poor clip-ins at the line. Having raced the 5's last year, I knew this course. Elk Grove's L-shaped course features 180 degree turns that create a nightmarish accordion crashfest if you're in the back of the pack, somewhere I planned to stay far away from… plans change. For the first several laps, I stayed in the front 10 wheels, even chasing down a few attacks on the backstretch. For a bit it seemed that a break might get away, but despite my efforts to block they weren't quite far enough out to hold. Having been off the bike for most of July due to moving, vacation, and my insane work schedule, I knew that these August races would be tough, but I hadn't anticipated having little to no power coming out of the corners. For whatever reason, I just couldn't accelerate like I used to - a serious detriment in this race. With two to go I was spit out the back with a fellow teammate. We worked together to finish strong, determined not to let a pack of ~10 or so catch us. We managed to stay away, finishing in the bottom of the results.
In all, a well organized event despite some challenges at registration. I just need to figure out where the hell my power went. If anyone finds it, let me know - I'll have you overnight it to me. I could use it.


text:
Eva Longoria's bum gets bigger
Eva Longoria has added an inch of muscle to her bum - in just two months.The 'Desperate Housewives' beauty has thanked her personal trainer, Patrick Murphy, for her new improved rear.
She is quoted in Britain's The Sun newspaper as saying: "With all the lunges and squats and leg presses, I've gained an inch of muscle in my butt."
Eva, who plays bed-hopping Gabrielle Solis in the hit series, admitted to putting on a few pounds after she first hooked up with her Basketball star boyfriend Tony Parker.
The brunette even complained she was struggling to fit into some of her outfits from the show.
She said: "I'm in love and I don't need to try anymore. I was getting upset that nothing would fit. I thought the costume designers were doing it because they wanted Gabrielle to be sexier."


text:
Marchant, R., Boom, A., Behling, H., Hooghiemstra, H., Melief, B., Van Geel, B., Van der Hammen, T. and Wille, M. (2004) Colombian vegetation at the last glacial maximum: a comparison of model- and pollen-based biome reconstructions. Journal of Quaternary Science, 19 (7). pp. 721-732. ISSN 0267-8179
Full text not available from this repository.Abstract
Colombian vegetation, at the ecological level of the biome, is reconstructed at the Last Glacial Maximum (LGM) using two methods. A reconstruction of modern biomes shows that, for the majority of the sites, the pollen data accurately reflect the potential vegetation, even though much of the original vegetation has been transformed by agricultural practices. At 18 000 14C yr BP a generally cool and dry environment is reflected in biome assignments of cold mixed forests, cool evergreen forests and cool grassland/shrub, the latter extending to lower altitudes than presently recorded. Differential responses of the vegetation to climatic shifts are related to changes in moisture sources and the importance of edaphic control on the vegetation. Secondly, biomes at the LGM are also investigated by applying a vegetation model (BIOME-3) set to operate at CO2 levels of 200 ppmV and with climatic data from 12 meteorological stations that encompass a range of environments within Colombia. At lower altitudes it is apparent that moisture is the dominant control on driving vegetation change whereas temperature becomes more important at higher altitudes. The combined reconstruction of biome-scale vegetation dynamics in Colombia allows an understanding of the environmental controls on these to be developed that demonstrates the need to invoke different factors to explain the vegetation change rather than a uniform reduction in temperature or moisture.
Item Type: | Article |
Institution: | The University of York |
Academic Units: | The University of York > Environment (York) |
Depositing User: | York RAE Import |
Date Deposited: | 24 Jul 2009 15:08 |
Last Modified: | 24 Jul 2009 15:08 |
Published Version: | http://dx.doi.org/10.1002/jqs.878 |
Status: | Published |
Publisher: | John Wiley & Sons, Ltd |
Identification Number: | 10.1002/jqs.878 |
URI: | http://eprints.whiterose.ac.uk/id/eprint/6858 |


text:
Nigeria has pledged to prevent at least a million deaths of women and children by 2015 by improving access to cheap medicines and interventions set out by the United Nations.
President Goodluck Jonathan is expected to launch Save One Million Lives initiative this Tuesday.
The pledge follows a UN report which listed 13 commodities that could save some six million lives by 2015 as well as 10 recommendations to improve access.
Director of the UN Population Fund, Dr Babatunde Osotimehin, has called for African countries seeking to implement the UN recommendations to focus on persons younger than 30 years, who make up 60% of their populations.
Addressing delegates from Rwanda, Nigeria, Senegal, Uganda, Tanzania, Ethiopia, the Democratic Republic of Congo, and Sierra Leone as the meeting opened in Abuja Sunday, Osotimehin said: "It is important that the health, education, and reproductive health of these 60% must be front and centre of the agenda."
He noted they would determine the extent of success of achieving Millennium Development Goals, adding, "I don't see how we can be talking about gender equality when women are still dying" from preventable causes.
Minister of state for health Muhammad Pate said a priority of SOML would be to address equity by "reallocating and improving the efficiency of our spending."
"We need to shift spending to basic interventions that can save lives," he emphasised.
$200 million plan
The recommendations call for countries to have pooled their procurement and demand for the life-saving commodities in order to ensure optimal price and volume by next year.
They also call for innovations in financing the commodities and efficiency in regulation by 2015.
Health ministers from Nigeria, Rwanda, Uganda, Tanzania, Ethiopia, the DRC, and Sierra Leone are meeting for the first time in Abuja to seek ways of implementing the recommendations.
Implementing the plans is estimated to cost $200 million over the next three years, excluding the cost of purchasing the commodities, according to the UN.
The recommendations were contained in a September report submitted by President Goodluck Jonathan and Norwegian prime minister Jens Stoltenberg, both co-chairs of the UN Commission on Life-Saving Commodities.
"Weak supply"
The recommendations lists 13 commodities, including:
Oxytocin and misoprostol to prevent and treat bleeding after birth, which is thought to be a leading of cause death among pregnant women
Magnesium sulphate to prevent eclampsia
Injectable antibiotics to treat infection in newborns
Chlorhexidine to prevent infection of umbilical cords at birth
Amoxicillin tablets to treat childhood pneumonia
Zinc and oral rehydration solutions to treat diarrhoeal diseases
Contraceptive implants
Emergency contraception
Female condoms
"These are not new drugs," Osotimehin explained at a press briefing Sunday.
"But what we find is that in most countries, the supply chain system is weak."
He added countries needed "political will to ensure you provide the drugs to buy, make sure they are distributed, make sure they are tracked, make sure that people use them."
UN resident coordinator in Nigeria, Daouda Toure, declared the UN is "ready to work to bring this critical initiative to the people who stand to benefit from the recommendations."
Nigeria's implementation plans, to be finalised Tuesday, will focus on ensuring more children and women have access to the drugs.
Oral rehydration solutions and zinc alone could save the lives of up to 1.89 million children aged under five globally in the next five years, according to the UN.
But only one in four children in Nigeria has access to oral rehydration salts, said Osotimehin.
And 70,000 children annually are born positive to HIV, a transmission that can be prevented.


text:
Liza Queen Is Back and at Smorgasburg
Those wondering what happened to Liza Queen after she closed the Queen's Hideaway in 2008, wonder no more. The Sunday Night Dinner in Astoria
The chef, who arguably was the first to make Greenpoint a dining destination with the kind of quirky, seasonal, vaguely Southern-accented food that would soon come to define vast swaths of Brooklyn, is resurfacing at Smorgasburg this Saturday.
This news comes courtesy of The New York Times, which reports that Queen has a new concern called Queen's Dahn Tu. After closing Queen's Hideaway, she went off to Vietnam, where she studied the country's cuisine. She'll be selling some of the fruits of her newly acquired knowledge, including banh xeo (an omelet-crepe stuffed with meat or vegetables) and banh tran tram, a concoction of shredded rice paper, fried shallots, hard-boiled quail eggs, and shredded green mango.
Smorgasburg, with its profusion of meticulously wrought goods from both established chefs and scrappy vendors, would seem to be a logical landing place for Queen, both in spirit and sensibility. And between her and the other 99 or so Smorgasburg vendors, we may very well bear witness to the most pure distillation of Brooklyn's artisanal chauvinism to date. It is sure to be a sight to behold, and digest; we're already anticipating the untold number of blog posts and trend pieces that will undoubtedly follow with no small degree of awe, and fear.
Have a tip or restaurant-related news? Send it to firstname.lastname@example.com.
And follow us on Twitter: @ForkintheRoadVV.
Sponsor Content


text:
Off Limits
It was funds while it lasted: The RTD board was so proud of its hastily adopted (and sadly unconstitutional) Resolution 15, "'Guide the Ride' is NOT for sale," that in late August it sent a hurried notice to potential RTD bidders, warning them that if they wanted to bid on future projects connected with Guide the Ride, they couldn't donate more than $100 to the campaign pushing the November ballot item (and its potential $20 billion booty).
But then the ACLU had to go and spoil all the fun. In early September, attorney and Colorado ACLU chair Ed Ramey challenged the resolution's constitutionality--and won a temporary injunction against it in U.S. District Court. Pending the outcome of the trial (conveniently set for after the November 4 election), even corporate fat cats have the right to free speech, which, believe it or not, extends to campaign donations--and, presumably, buying elections that will make the fat cats even fatter.
Bloodied but unbowed, the RTD board has appealed the court's decision. In the meantime, though, it had to send a second notice to potential bidders. "Pursuant to the court's mandatory injunction," the card noted, "you are hereby notified that Resolution No. 15 is no longer in effect."
Your tax dollars at work: The two mailings cost $5,000, estimates RTD spokesman Scott Reed.
Which, coincidentally, was the cost of one ticket to Monday night's pro-Guide the Ride dinner at the Oxford Hotel. But the fat cats who bought their way in got an appetizer they didn't bargain for: Assorted protesters, including renegade RTD boardmember Jon Caldara, hectored arriving donors with signs ("Don't Buy the Lie") and questions about what they stand to gain from the tax increase. When Governor Roy Romer showed up, Caldara shouted, "How much is your son making off this?"--a reference to Chris Romer's position at George K. Baum and Company, RTD's bond dealer. The governor offered no reply.
Back-to-school special: Former Overland football star Scott Bentley--who rated a spread in Sports Illustrated while still in high school and was heavily recruited by both Notre Dame and Florida State--got a second chance at the NFL when the kicker was called up by the Broncos this week. (He made two out of three field-goal attempts at Monday night's game.) But this wasn't Bentley's first second chance. The local-boy-made-good went bad fast at Florida State where, as a sophomore, he pleaded no contest in May '94 to charges that he'd illegally tape-recorded himself having sex with a Florida A&M pre-nursing student without her consent--and then played the tape for friends. Bentley was fined $500 and sentenced to forty hours of road-crew work.
And another Coloradan recently made the news in Florida. At one point, Margaret M. Ray was this state's most infamous export, back when the former resident of Crawford tried to take up residence in David Letterman's Connecticut home--but instead had to content herself with stalking the TV yakker, stealing his Porsche in 1988 and camping on his tennis court in 1993. After several convictions, Ray spent a year and a half in a mental hospital, where she penned this missive about Letterman: "Although I continue to give him the opportunity to integrate me into his household, he decides otherwise, on behalf of us both. Case closed."
Not exactly. Late last month Ray was charged with stalking former NASA astronaut Story Musgrave. She was apprehended, dripping wet, outside his Orlando, Florida, home, where she'd turned on all the faucets. Ray must have a thing for water as well as celebrities: She once did her laundry in Letterman's pool.
Post toasties: By one veteran's count, the Denver Post has lost 24 newsroom employees in the past 18 months--including Pat O'Driscoll, who left to open a local bureau for USA Today, and Alan Gottlieb (both were omitted from our rundown two weeks ago). Now you can add another to the long list: Robert Kowalski, a member of the paper's defunct investigative team, is moving on to a job as a political reporter in Alaska.
Also heading out of town this week is former Post restaurant reviewer John Kessler, whose house--owned by your-friend-in-the-diamond-business Tom Shane in the early Seventies--is now on the market. Among those treated to a showing was attorney Michael Tigar, who's apparently contemplating a long stay in Denver--although not in the Shane/ Kessler house. "Too much work," he told the realtor.
What does he call defending Terry Nichols?
Sponsor Content
More NEWS
- Still Living With Your Parents? Here Are Five Reasons You Should Move Out
Upcoming Events
Colorado Rockies vs. Arizona Diamondbacks
Wed., May 6, 1:10 p.m. -
Colorado Rockies vs. Los Angeles Dodgers
Fri., May 8, 6:40 p.m. -
Colorado Rockies vs. Los Angeles Dodgers
Sat., May 9, 6:10 p.m. -
Colorado Ice vs. Bemidji Axemen
Sat., May 9, 7 p.m.
- Dear Mexican: Why Do Mexican Men Have Such Thick Hair?
- Cannabis Calendar for the Week of April 27: 4/20 Hangover


text:
Diary of a devious dude
September 10th 2006 12:56 am[ Leave A Comment ]
What was that? Did you see? The Sammy SummerSeptember 6th 2006 11:39 pm[ Leave A Comment ] Well, over 2 months and those girls (Tiger and Peanut) STILL give me a hard time!!! Sometimes Peanut even pees on the floor (hehehe, I told!!)!! Jasper and I had a playdate with our other friend Hailey a few weeks ago. She didn't much like us either, so we just played by ourselves....hmmmm...must be a girl thing. Once I even gave up my chair so that Peanut could sit in it...I was trying to be a nice friend. I hope she and Tiger start to be nice to me and Jas soon. My new home!July 1st 2006 3:53 pm[ Leave A Comment ] My mommy uploaded some pics of me at our new home! There's a HUGE yard for me to play in!! I love it!! My Tail of Devotion for SamJune 21st 2006 11:41 pm[ Leave A Comment ] Love mom
I was a bad boy...June 21st 2006 11:22 pm[ Leave A Comment ] I leaped up onto the counter when mom wasn't looking to get myself a snack...but mom caught me at the crucial moment!!! Darn!!! Moving???May 27th 2006 10:40 am[ Leave A Comment ] Jasper keeps telling me we are moving!! I don't want to!!! We keep on visiting Tiger and Peanut and I put up a big fuss, and I even scratch mommy and daddy! This is going to take some adjusting, I hope mommy isn't thinking of giving me away. I've already had so many homes in my lives and I finally found one that I like!! I hope mommy will still live with us. Tiger and Peanut seem nice, but I've been pretty blunt with them...maybe I should give them a chance... |
Sort By Oldest First
Sam (Rainbow Bridge) Family Pets
Subscribe |


text:
Children's Hospital Colorado
I want to be a hairstylist.
Academic - ProfessorClinical - Co-Director, Colorado Fetal Care Center
Top Doctor in Denver Awarding Body: 5280 Magazine Date: 2011 Description: Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
National Faculty Award for Excellence in Resident Education Awarding Body: CREOG Date: 2004
Award for excellence in teaching Awarding Body: APGO Date: 2002
Texas A&M University School of Medicine - Medicine (1989)
Scott & White Memorial Hospital - Obstetrics & Gynecology (1990)
Scott & White Memorial Hospital - Obstetrics & Gynecology (1993)
University of Texas Health Sciences Center - Maternal/Fetal Medicine (1995)
Texas A&M University School of Medicine (1987)
University of Texas at Austin - Biology (1985)
Centura Health System Perinatal Safety Task Force Committee - Member ACOG - Member SGi - Member SMFM - Member PRS - Member Colorado Gynecologic Obstetrical Society - Member AIUM - Member
12631 East 17th Avenue, B198-05Aurora CO, 80045-2529
(720) 848-1844
Children's Hospital Colorado on Anschutz Medical Campus


text:
'Numbers are large and clean, easy to read'
'Reasonable cost'
'Easy to use'
'Improved interface'
'Heart beats per minute are tracked and calorie computations are ongoing, and a comprehensive data analysis is available on the display as the run progresses.'
'It sits slightly high on the wrist but this has an advantage as it means the two buttons on the right side of the body don't push into the back of the wearer's hand during physical activity, which is a common bane of many sports watches.'
'Excellent battery life'
'Extensive customization options'
'Light and compact'
'Online Connect Portal'
© 2007-15 ReviewGist.com. All Rights Reserved. Best Garmin 3 Outdoor Activities GPS Devices


text:
ISO 6182-5:2012 specifies performance requirements, methods of test and marking requirements for deluge valves and manufacturer's specified relevant trim used in deluge and pre-action automatic fire protection systems. Deluge valves covered by these requirements can be operated by hydraulic, pneumatic, electric, mechanical, manual, or thermal means, or combinations thereof.
Performance and test requirements for other auxiliary components or attachments to deluge valves are not covered by ISO 6182-5:2012.
ISO 6182-5:2012 does not cover thermally operated valves released by heat acting directly on the valve. This type of valve utilizes a thermal device, such as the link-and-lever arrangement or glass bulb of a sprinkler, to hold the valve closed. Operation of the thermal device allows the valve to open.
Document published on: 2012-12-01 Edition: 3 (Monolingual) ICS: 13.220.20 Status: Published Stage: 60.60 (2012-12-06) TC/SC: ISO/TC 21/SC 5 Number of Pages: 19 -
Revises: ISO 6182-5:2006


text:
To: | email@example.com (SGI/Linux mailing list) |
Subject: | Web site rearrangement |
From: | email@example.com (Ariel Faigon) |
Date: | Tue, 9 Feb 1999 18:04:10 -0800 (PST) |
Organization: | Silicon Graphics Inc. |
Reply-to: | email@example.com (Ariel Faigon) |
Sender: | firstname.lastname@example.com |
Just FYI, To reflect the recent SGI official announcements, reduce media confusion, and have a more logical organization of the Linux on SGI web site, we've moved the 'mips' stuff one level down and added a separate Intel hierarchy (which is pretty empty right now but expected to grow in the future). If you find broken links etc. please let me know. -- Peace, Ariel |
<Prev in Thread] | Current Thread | [Next in Thread> |
Previous by Date: | Re: glibc SRPM, Joan Eslinger |
Next by Date: | mysql-3.22.16a-gamma, Radim Uchac |
Previous by Thread: | glibc SRPM, Joan Eslinger |
Next by Thread: | mysql-3.22.16a-gamma, Radim Uchac |
Indexes: | [Date] [Thread] [Top] [All Lists] |


text:
Aero suppliers urged to look beyond Boeing
"The history here in Washington state is that every time we win a project from Boeing, we get complacent, and we can't have complacency again," said Scott Hamilton, an analyst with Issaquah-based Leeham Co.
"We still need to look behind Boeing, and we still in my view need to look beyond brick-and-mortar type of aerospace as well," he said.
For example, as air travel continues to grow, a pilot shortage is expected in coming years, and Washington should develop world-class training programs, Hamilton said.
In terms of more traditional aerospace manufacturing, the state's industry needs to pursue work with other major airplane makers, such as Airbus, Bombardier and Embraer.
Representatives from those three companies and Boeing all spoke at the three-day conference, annually hosted by the Pacific Northwest Aerospace Alliance at the Lynnwood Convention Center.
The Airbus representatives said they couldn't comment on the potential for new suppliers from the Pacific Northwest.
But Airbus Americas officials have previously said they plan to do more work with U.S. suppliers. Among the states, Washington already does the second-most business with the company, with about $200 million in purchases a year.
Like Boeing, the company has pushed suppliers to cut costs, said Daniel Wenninger, an executive with the Airbus A350 XWB program in the U.S.
Representatives from three of the aerospace industry's big jet engine makers — Rolls-Royce, GE Aviation and Pratt & Whitney — discussed their companies' respective programs.
Bob Saia, a vice president with Pratt & Whitney, said that while the three companies might be pursuing different technological innovations, engine buyers in the end all want the same thing: more powerful, lighter-weight and more-efficient engines.
East Hartford, Conn.-based Pratt & Whitney is focused on refining its engines, which are built for narrow-body and smaller aircraft, and in the near future will leave the wide-body market to GE Aviation and Rolls-Royce, he said.
The company still plans to certify its PW11000G engine for the Airbus A320neo later this year, Saia said.
The fight for the wide-body market has been fierce and will likely increase in the next decade, said Jason Brewer, general manager of GE Engines marketing.
Engine makers can't bet their company on one technology but have to be ready to deliver the right combination of technology available to meet demand, said Bill Boyd, a senior vice president with Rolls-Royce.
Meantime, in Olympia on Thursday, Washington's top economist, Steve Lerch, presented the latest forecast from the state Economic and Revenue Forecast Council, which projects a decline of about 7,000 aerospace jobs in the next few years.
The drop is due in part to the fact that Boeing is making airplanes more efficiently and isn't replacing some retiring workers, Lerch said.
Dan Catchpole: 425-339-3454; firstname.lastname@example.com.
Construction is fast and furious at Smokey Point Business offers tips on crime prevention You're right: Toilet paper sheets are shrinking Volkswagen Golf gets great mpg, even in the left lane Google expanding fiber service to 4 Southeastern metro areas Fishermen fear monopoly by Pacific Seafood Group
Share your comments: Log in using your HeraldNet account or your Facebook, Twitter or Disqus profile. Comments that violate the rules are subject to removal. Please see our terms of use. Please note that you must verify your email address for your comments to appear.
You are logged in using your HeraldNet ID. Click here to update your profile. | Log out.
Our new comment system is not supported in IE 7. Please upgrade your browser here.


text:
5 Heroes We Want in Dissidia
9d ago -
Square Enix have announced a brand new Dissidia. A Pixelated View indulges in a little fantasy of... | Arcade
10 Games you need to play on the PlayStation TV
216d ago -
From the article, "The PlayStation TV is coming out on October 14, 2014, and this $100 micro-cons... | Culture
Help Myriad get through Steam Greenlight!
Now - Myriad is a twin-stick shooter that grows more beautiful the better you play, where you build and then destroy the game space in glorious chain rea... | Promoted post
The Best and Worst Final Fantasy Spinoffs
227d ago -
On the heels of Square Enix's announcement of Final Fantasy: World Wide Words, Stephen from Levia... | PSP
Dissidia: Final Fantasy – Review Gamerspective
382d ago -
If you ever wanted to see your favourite Final Fantasy characters beat the holy hell out of each... | PSP
Work on Final Fantasy XV Proceeding Smoothly; Final Fantasy X-3 Development Denied and More
384d ago -
Yesterday a few wild rumors appeared on the web about the alleged development of Final Fantasy X-... | PS4
Final Fantasy Go There Special Interview Report
417d ago -
A new interview with Kitase Yoshinori, Toriyama Motomu, Yoshida Naoki & Hazama Ichirou. In this i... | Wii
The Dumbest Game Names Square Enix Ever Inflicted on Us
444d ago -
Wired: Today is the North American release date for Bravely Default, a fine role-playing game wit... | PS2
Final Fantasy Sale on PSN This Week, Next Week Persona 2: EP and Persona 3: FES Discounted
455d ago -
This week Sony will be discounting plenty of Final Fantasy titles on PSN, while Atlus announces t... | PS3
Several Final Fantasy Games Discounted On European PSN
460d ago -
Multiple Final Fantasy games are soon to become available for a reduced price on the European PSN. | PSP
Remembering the last generation: The best fighting games
471d ago -
Writers of the 16bitkings discuss their favourite fighting/beat'em up games from the previous con... | PSP
Kana's Korner – Interview with Chris Smith
473d ago -
Twice the Christmas means twice the fun! Voice actor Chris Smith dropped by to have a chat about... | Culture
Dissidia And Theatrhythm Were Made To Introduce Final Fantasy To A New Generation Of Fans
525d ago -
"In an interview with Japanese magazines this week, Square Enix producer Ichiro Hazama, known for... | Culture
Top Ten RPG Characters
528d ago -
Dawnbreaker gives us her personal and completely biased list of the Top 10 RPG characters. | PS2
Five Funniest Jabs At A Rival Video Game Company
715d ago -
GP writer Jared discusses 5 different funny jabs between different video game companies through t... | PSP
Final Fantasy Dissidia 012 Character List
775d ago -
"We wanted to share the list of character from dissidia as well as a description for each. The co... | PSP
Top 10 Hammiest Performances in a Video Game (with Videos!)
803d ago -
GameDynamo - "The conventional wisdom will often tell an actor to play a character with a nuance... | PS2
Postcard Review: Damn it, Dissidia!
812d ago -
"When the original Dissidia came out, every fiber of my being exploded in explosive fandom joy. N... | PSP
Huge Final Fantasy sale starts on PlayStation Store this week
826d ago -
With over 100 million units sold worldwide this is one of the most successful gaming series in hi... | PSP
Top 10 Higher-Profile PSP Games You Need to Download for PS Vita
1000d ago -
GameDynamo - "Those who say the PlayStation Portable was failure are only referring to its expect... | PSP
This Week's Sale On PlayStation Store (EU)
1028d ago -
EU PSBlog:
Hello Everybody!
I hope you've all enjoyed the PS Vita sale last week, I know I di... | PSP
Follow Releases.com on Twitter
Now - Get the latest release dates for games, movies and TV Series from our Twitter page. | Promoted post
PS2 HD Collections we NEED to see (Part 3)
1076d ago -
In the third and final part in our HD Collections feature, PSU.com looks potential offerings from... | PS2
KHPlanet Monthly Interview: Bryce Papenbrook (Tales of Graces f – Asbel)
1103d ago -
This month, we have Bryce Papenbrook, the voice of Zidane from Dissidia: Final Fantasy and Asbel... | PS3
Game Music for the Masses
1109d ago -
We Are Arcade takes a look at the (un) surprising result this weekend of game track entries into... | PC
Dissidia 012 [Duodecim] Review - BlazingStarGames
1113d ago -
Square Enix, masters of the RPG, having a stab at a fighting game? Crazy it may sound, but it's a... | PSP
Final Fantasy Mini Kai Figures Coming to Europe
1122d ago -
Square Enix Ltd. has revealed that the popular Final Fantasy Mini Kai Figures are set to get an o... | PS2
Page 1
Next page »


text:
On November 20, 2014, the District Court for the District of Columbia once again ordered Kellogg, Brown and Root ("KBR") to produce all documents prepared as part of an internal investigation. The District Court's decision...more
1/23/2015 - Attorney-Client Privilege Corporate Counsel Document Productions False Claims Act Internal Investigations Kellogg Brown & Root Privilege Waivers Qui Tam
You are counsel to a government contractor that is conducting an internal investigation into possible fraud. Federal mandatory disclosure obligations require an investigation, as does the need to gather facts to seek legal...more
8/25/2014 - Attorney-Client Privilege Chief Compliance Officers Compliance Disclosure Requirements False Claims Act Federal Contractors Fraud Internal Investigations Kellogg Brown & Root Work Product Privilege Work-Product Doctrine
In a much-anticipated decision, the D.C. Circuit clarified the general test for the applicability of the attorney-client privilege in internal investigations. In re Kellogg Brown & Root, Inc., 14-5505, 2014 WL 2895939 (D.C....more
7/31/2014 - Attorney-Client Privilege False Claims Act Internal Investigations Kellogg Brown & Root Work-Product Doctrine
On March 6, 2014, the District Court for the District of Columbia issued an opinion in United States ex rel. Barko v. Halliburton Company et al. that should serve as a wake-up call for all companies conducting internal...more
3/26/2014 - Attorney-Client Privilege Fraud Internal Investigations Work Product Privilege
The SEC awarded more than $14 million to a whistleblower earlier this month in exchange for information that helped the SEC bring an enforcement action against the perpetrators of an investment fraud in less than six months...more
10/25/2013 - Compliance Dodd-Frank FCPA SEC Whistleblower Awards Whistleblowers
On August 15, 2013, the Ontario Superior Court found Canadian national Nazir Karigar guilty of conspiring to offer a bribe to Indian government officials under the Corruption of Foreign Public Officials Act ("CFPOA"). The...more
9/30/2013 - Bribery Canada CFPOA Enforcement Government Officials Tribal Governments
The healthcare industry has been under increased SEC and DOJ scrutiny lately for potential FCPA violations. What has been described as an "industry sweep," has focused primarily on medical device and pharmaceutical companies....more
1/23/2013 - Compliance DOJ Due Diligence FCPA Foreign Official Healthcare Pfizer SEC
In Banner Health System d/b/a Banner Estrella Medical Center, 358 N.L.R.B. No. 93 (2012), the National Labor Relations Board (NLRB) held that an employer's maintenance and application of a general confidentiality rule...more
11/27/2012 - Banner Health System Confidential Employer Investigations Internal Investigations NLRA NLRB Section 7
Internal Investigations
Attorney-Client Privilege
False Claims Act
Kellogg Brown & Root
Work Product Privilege
Work-Product Doctrine
Banner Health System
Chief Compliance Officers
Confidential Employer Investigations
Corporate Counsel
Disclosure Requirements
Document Productions
Sign up for your custom alerts now, using LinkedIn ›


text:
Best of video on independent.co.uk
General Election 2015: US statistician Nate Silver predicts Conservatives will win most seats but 'enormous uncertainty' over formation of final government
But Silver said Ed Miliband could form a minority government with the 'consent' of the SNP but warned it would be an 'incredibly messy outcome'
Letter from the Whitehall Editor: The spurious Tory endorsement that misfired
In the spin doctors' lexicon they are known as "third-party endorsements". The idea is that if you want to sell a policy the best way to do it is to get businessmen/charities/the great and good to back your point of view "independently".
Alastair Campbell & Andy McCann: 'I was worried someone would attack me at the Chilcot Inquiry. So I called in Andy'
Tony Blair's former spin doctor met the mental-skills performance coach soon after he left Downing Street and they are now firm friends
Silent Hills: hugely anticipated game is definitely cancelled, Konami says
Game had been set to be developed by industry favourite Hideo Kojima and director Guillermo del Toro, and featured acting from Walking Dead star, but studio has confirmed rumours it is cancelled
Strappy shoes are this summer's look
Part sandal, part ballet slipper – the shoe style of the summer is a romantic take on a classic. It's time to get tied up.
Centrica's shareholders protest over new chief's pay package
British Gas now has 14.8 million customers, down from a peak of more than 17 million
Baltimore riots: Huge fire lights up sky as seniors' centre erupts in flames
Church community centre was recently completed
Inside Harley Street, BBC2 - TV review
Vanessa Engle's three-part documentary has provided fascinating insight into private healthcare and cosmetic medicine, but she'd saved the real characters till last
The science of weather forecasting: The pioneer who founded the Met Office
Moved by a terrible shipwreck, Robert FitzRoy pioneered the science of weather forecasting. But for all the lives saved by his observations, he couldn't see the value in his own.
Jose Mourinho tells Chelsea critics to 'Go play on the moon'
Manager defends 'boring' side and Terry attacks 'tippy-tappy' football
National Stationery Week: 12 best thank you cards
Celebrate National Stationery Week with a handwritten note to show your appreciation. The IndyBest team put pen to paper
Tour guides should cut to the chase and make it snappy
I never get bored when travelling, but boy, tour guides have taken me perilously close.
- 1 Frank Lampard's face drops when Holly Willoughby introduces him as a 'Man City legend'
- 2 Sofyen Belamouadden murder: The inside story of a crime that horrified Britain
- 3 Company breaks open Apple Watch to discover what it says is 'planned obsolescence'
- 4 The Visit: Trailer for M Night Shyamalan's latest horror film is terrifying
- 5 9/11: Iranian General accuses US of organising September 11 terror attacks
General Election 2015: Tories sack candidate who said she would never support 'the Jew' Ed Miliband
9/11: Iranian General accuses US of organising September 11 terror attacks
General Election 2015: Stephen Hawking says he will vote Labour
Manny Pacquiao begs Indonesia president to spare life of drug smuggler Mary Jane Veloso about to be executed
Yazidi sex slaves undergoing surgery to 'restore virginity' after being raped by Isis militants
General Election 2015: Chuka Umunna on the benefits of immigration, humility – and his leader Ed Miliband
The sickening truth about food banks that the Tories don't want you to know
Aaron and Melissa Klein: Oregon anti-gay bakers ordered to pay $135,000 after refusing to make cake for same-sex wedding
Andrew Lloyd Webber: Phantom of the Opera writer mocked after issuing a warning about Ed Miliband and Nicola Sturgeon
General election 2015: Labour will toughen hate crimes legislation surrounding Islamophobia
HSBC review into moving headquarters from UK 'underway'
Framing Fashion with Oliver Proudlock
Watch the first video in our new series for tips on new trends and London's style scene.
Back to nature
Check out our insider's tour of Menorca's beaches, from the accessible to the remote.
Win up to £15K to bring your idea to life
The Evening Standard has teamed with Born to find the next big innovation. Find out how you can win £15K to bring your idea to life...
The battle of Hallam
The hotly contested Sheffield seat has the most educated voters in the country. Will they show their displeasure at the Lib Dems' tuition fee u-turn by ousting Nick Clegg?
Win £125 of glasses with Specsavers
The Evening Standard have teamed up with Specsavers to offer readers the chance to win stylish frames and sunglasses to boost your spring look.
There's more to New York than just business
We've teamed up with Hilton Garden Inn to give away a fantastic 5 night trip to New York
It's always a good time to visit Barbados
Discover Barbados with this amazing promotion from Brilliant Barbados, giving visitors more than ever before.
Discover Tobago for FREE!!
We are offering one lucky reader the chance to win a seven night self-catering holiday for two. What are you waiting for? Enter now.
Voting Clever
Detailed polls show where certain seats can be won – or lost – by the power of the student vote. Those who use the polls strategically could really make a difference, writes Lucy Hodges
Health professionals create a design for life
A team at Sheffield Hallam University have designed a revolutionary new neck brace that could transform the lives of Motor Neurone Disease (MND) patients.
Enter the latest Independent competitions
Win anything from gadgets to five-star holidays on our competitions and offers page.
Business videos from commercial thought leaders
Watch the best in the business world give their insights into the world of business.
Independent Dating
Day In a Page
Loweswater, Cumbria
Longtown, Carlisle
Tilshead, Wiltshire
Cowes, Isle of Wight
Shanklin, Isle of Wight
Dorchester, Dorset
Stamford, Lincolnshire
Horsham, West Sussex
Shepherd's Bush, W12
Knighton, Llandrindod Wells
Selby, North Yorkshire
Norwich, Norfolk
Truro, Cornwall
Greenbank, Edinburgh
Crossgar, Co. Down
Stroud, Gloucestershire
Gargrave, Skipton
Colindale, NW9
Padstow, Cornwall
Leeds, West Yorkshire
Keswick, Norfolk
Warleigh, Bath
Streatham, London SW16
Bower Hinton, Martock, TA12
Marlow, Buckinghamshire, SL7
Henley-On-Thames, Oxfordshire, RG9
Stockwell, SW8
Shaftesbury, Dorset, SP7
Haslemere, Surrey, GU27
Newport, TF10
Clapham, SW4
Mayfair, W1K
St. Mawgan, Newquay, TR8
Sinai Hill, Lynton, EX35
South Bank, SE1
Calverley, West Yorkshire, LS28
Northney Lane, Hayling Island, PO11
Putney, SW15
Cobham, KT11
Old Buckenham, Norfolk
Windermere, Cumbria, LA23
Tunbridge Wells, Kent, TN2
Richmond, TW9
Pebworth, Worcestershire, CV37
Marylebone, W1W
Fulham, SW6
Cookham, Maidenhead, SL6
Windsor, Berkshire, SL4
Liskeard, Cornwall PL14
Bath, BA1
Loweswater, Cumbria
Surrounded by the Western fells, this five-bedroom Georgian home retains many original features including panel-plastered ceilings, sash windows and fireplaces.
Longtown, Carlisle
This six-bedroom home is set amongst three acres of grounds. Currently a large family home, Clift Hill has potential to make a B&B, subject to change of use permissions.
Tilshead, Wiltshire
A former period coach house, Glebe Farm Stable is now a three-bedroom cottage with a double car barn, office, kennels and an outbuilding that's currently used as a gym.
Cowes, Isle of Wight
Set sail for this four-bedroom farmhouse in Cowes. With five acres of land and an indoor pool, this home oozes character. There is even potential to let a one-bedroom annexe.
Shanklin, Isle of Wight
Surrounded by woodland, this five-bedroom manor house has plenty of outdoor storage space in the form of three converted loose boxes, two smaller outhouses and a woodstore.
Dorchester, Dorset
This four-bedroom detached home comes with a double carport, useful workshop, garden and two walkways that offer views of the adjacent countryside.
Stamford, Lincolnshire
With space for an equestrian business, a greenhouse for growing your own veg, a wine store and a gym; this five-bedroom home has all the ingredients for a country retreat.
Horsham, West Sussex
This four-bedroom home has exposed brick chimneys and a vaulted ceiling in a breakfast room that's ideal for summer entertaining - the doors open to the patio and garden.
Shepherd's Bush, W12
The decked roof terrace of this two-bedroom flat is perfect for summer drinks while large windows and ample storage space make for a light and spacious interior.
Knighton, Llandrindod Wells
Surrounded by approximately 15 acres of grounds, this six-bedroom grade II-listed home has been extensively refurbished yet retains many period features.
Selby, North Yorkshire
This four-bedroom home comes with a two-bedroom cottage and commercial office, with planning to extend, in a stunning courtyard setting.
Norwich, Norfolk
In a pretty Norfolk village, this four-bedroom family home is surrounded by landscaped gardens, with even a self-contained annex for guests.
Truro, Cornwall
A few miles from the seaside at Perranporth, this four-bedroom farmhouse sits amongst nine acres of idyllic grounds - including a lake and two barns used as holiday lets.
Greenbank, Edinburgh
This five-bedroom home is arranged over three floors of a converted Victorian hospital, offering spectacular views of the Pentland Hills - only three miles from the city centre.
Crossgar, Co. Down
This four-bedroom detached home comes with grounds that span to approximately 2.5 acres, as well as two large patio areas and a double garage.
Stroud, Gloucestershire
This four-bedroom cottage is a Grade II-listed town house, well-located for the thriving market town of Nailsworth.
Gargrave, Skipton
A four-bedroom apartment on the ground floor of a stunning period property in North Yorkshire, with two kitchens and a large south-west facing garden.
Colindale, NW9
This high-spec two-bedroom home is part of a smart collection of new flats at Beaufort Park and has a large decked balcony that's perfect for summer drinks.
Padstow, Cornwall
Capitalise on the fabulous views of Trevone Bay by taking two homes and creating one spacious boutique B&B. Just a cliff-top walk from Padstow.
Leeds, West Yorkshire
Overlooking a golf course, this six-bedroom Edwardian detached home spans four storeys and retains many period features including the original, operational servants' bells...
Keswick, Norfolk
On the edge of the city, this six-bedroom home comes with an outdoor swimming pool and a large garage block that has annexe potential.
Warleigh, Bath
In a Grade II-listed manor just outside of Bath, this three-bedroom home is arranged on two floors with a skylight in a vaulted roof line.
Streatham, London SW16
Open the living room's bi-fold wooden doors to reveal a retro-style kitchen, and a conservatory leading to a paved garden at this three-bedroom home.
Bower Hinton, Martock, TA12
A Grade II-listed, four-bedroom home, in a charming Somerset village, with a two-storey studio that could be converted into a holiday cottage
Marlow, Buckinghamshire, SL7
A modern four-bedroom Victorian home, within walking distance to the high street
Henley-On-Thames, Oxfordshire, RG9
A luxury apartment in the Gothic mansion of Wyfold Court in Kingwood, offers six bedrooms spread over three floors and a turret
Stockwell, SW8
This school conversion, near Stockwell Tube, oozes New York loft style. The one-bedroom flat features double height ceilings and exposed brick work
Shaftesbury, Dorset, SP7
This six-bedroom Georgian home is on three floors with open fireplaces, a two-oven Aga, an annexe, and cottage gardens with outbuildings and a car barn
Haslemere, Surrey, GU27
High Crest House covers an impressive 9384sq ft, with almost three acres of grounds including a tennis court and summer house enclosed by electric gates
Newport, TF10
A six-bedroom farmhouse with separate accommodation in converted stables. Situated in the village of Church Aston, within walking distance to the market town
Clapham, SW4
A two-bedroom flat with under-heated walnut floors and bespoke built-in storage. The Tube and Clapham Common are a short stroll away
Mayfair, W1K
A refurbished seven-bedroom townhouse with staff quarters, cinema room, superb gym, steam room and plunge pool
St. Mawgan, Newquay, TR8
A minimnalist four-bedroom home designed to the highest spec, featuring glass walls and a kitchen space lit by a glass roof
Sinai Hill, Lynton, EX35
Hibernate during winter and make your living during the summer at this busy guesthouse with panoramic sea views, in the village of Lynton
South Bank, SE1
A four-bedroom penthouse next to the Tate with direct views of St Paul's from two floors of luxurious living space
Calverley, West Yorkshire, LS28
A four-bedroom detached home surrounded by spacious gardens and woodland, close to New Pudsey
Northney Lane, Hayling Island, PO11
An 18th-century, three-bedroom home near Langstone Harbour built from ships beams with vaulted ceilings and wood burning stoves
Putney, SW15
A six-bedroom home with five bathrooms, garden terrace, heated pool, gym and cinema
Cobham, KT11
A five-bedroom semi-detached home with a mix of period and modern features in a popular and convenient location
Old Buckenham, Norfolk
This five-bedroom red-brick beauty overlooks the village green and sits in just under two acres of land
Windermere, Cumbria, LA23
A three-bedroom villa with self-contained flat, minutes from Lake Windermere
Tunbridge Wells, Kent, TN2
A five-bedroom Victorian home with four receptions, superb gardens and paddock in Pembury
Richmond, TW9
An eight-bedroom house on the south side of the The Green with cinema, wine cellars and summer house
Pebworth, Worcestershire, CV37
This 17th century beauty is full of rustic cosiness, while the detached home office means you can also run a business
Marylebone, W1W
Four exclusive apartments in a Grade II-listed former medical school with 2,275 sq ft of living space and 18ft ceilings
Fulham, SW6
A five-bedroom terraced house on the popular Peterborough Estate, ideally located for both Eel Brook Common and South Park
Cookham, Maidenhead, SL6
A state-of-the-art farm-building conversion on the former Cliveden Estate, with 11,420sq ft of internal space, cinema and wine cellar
Windsor, Berkshire, SL4
Windsor Castle overlooks this three-bedroom Victorian cottage located on one of Windsor's smartest roads
Liskeard, Cornwall PL14
A four-bedroom former mil off the beaten track in Quethiock, £725,000
Bath, BA1
A boutique mews house, set around a central courtyard, with three bedrooms and a private roof terrace


text:
No results found.
No results found.
No results found.
Robert Carlyle |
David Russell |
Max Beesley |
Michael Ezard |
Benedict Cumberbatch |
Stephen Ezard |
Anamaria Marinca |
Yasim Anwar |
Christopher Fulford |
George Gibbon |
Geraldine James |
Barbara Turney |
Paul Higgins |
Professor Lawrence Cooper |
Guest Star |
Ovidiu Niculescu |
Bepa |
Guest Star |
Iona Serban |
Nadir |
Guest Star |
Alex Caan |
Haman |
Recurring Role |
David Calder is named as a show star in the opening credits, but does not appear in this episode.
This episode had 2.5 million viewers and an audience share of 10%.
Russell: I love the smell of napalm in the morning.
A line made famous by Robert Duvall's character, Kilgore in Apocalypse Now, uttered here by Russell just prior to his hideout exploding into flames.
User Score: 90
User Score: 129
User Score: 20
User Score: 5
User Score: 5
User Score: 3
User Score: 2


text:
Corporate Tax Kickbacks: Busting Our Budgets, State By State Federal tax giveaways to industries have received much criticism, but the relocation incentives offered by states may be the most counterproductive of all corporate subsidies.
The 10 States With the Most Trouble Paying Their Bills Balancing the budget isn't just a federal problem -- it's a state one, too. The Great Recession resulted in some of the lowest state revenues in years, and some of the biggest budget shortfalls ever -- in some cases, into the billions of dollars.


text:
Search Videos
Sort by: LatestMost PopularRandom
I suck at audio stuff so pardon my crappy transitions. I would have made it longer but the youtube… Tags: owl, city Angela Jan 28, 2010 30 views
*I OWN NOTHING, THIS VIDEO WAS MADE JUST FOR FUN, PLEASE DONT SUE* When I was reading New Moon I… Tags: this, hate QueenC May 26, 2009 85 views
Bella and Edward Tags: bella, edward Angela Mar 19, 2009 142 views
This is a video I made. Enjoy! Tags: dolls, googoo Karina Jan 17, 2009 34 views
Welcome toTwiFans-Twilight Saga books and Movie Fansite
Sign Upor Sign In
Or sign in with:
© 2015
Badges | Report an Issue | Terms of Service
Please check your browser settings or contact your system administrator.


text:
Go and visit http://www.trojanremovers.info/
So, as briefly explained it can open paths for harmful third parties or hackers to access your computer system from where they can execute scripts, modify files, remove programs and other things which will lead to a severely unstable system .One effect which causes the most concern and is something to chat about is the possibility of data theft. Once access has been granted to a hacker they can retrieve and steal and login data that relates to financial websites or other personal domains which could really hit you hard. Emails are another common method of distribution in which the hacker will attempt to infect a wide variety of computers on a network thereby allowing him to get remote access and ultimately control of those systems.
From here, they can easily watch your actions, capture keystrokes and possibly even watch every screen that is displayed on your system. With all this in mind it is best to download a free trojan cleaner application and check if your computer is infected today. Have a look at http://www.trojanremovers.info/
The signatures logs in these security tools give them the special ability to detect harmful content which will then be quarantined or removed automatically. Such programs are critical and should be utilized by most computer users especially in this day and age.One should be cautious if attempting to eliminate infections manually via registry modification because incorrect actions can result in severe problems for your PC.


text:
Teleconference meeting of Government Accountability Candidate Committee. See also Ch. 15.60(2).
The Government Accountability Candidate Committee will meet on Wednesday, February 22, in the Government Accountability Board Offices located on the third floor at 212 East Washington Avenue, Madison, Wisconsin. The purpose of the meeting is to select the nominees to fill the open seat on the Government Accountability Board. The meeting will begin at 12:00 noon.
The agenda for this meeting includes the following:
A. Call to order
B. Determination of Quorum
C. Approve Agenda
D. Review Committee Assignment
E. Discussion of Candidate Qualifications
F. Selection of Nominees
G. Other Business
H. Committee Directives
I. Adjournment
Attachment | Size |
G A B Candidate Comittee Meeting Notice -2 22-2012.pdf | 72.42 KB |


text:
Free shipping in the USA (lower 48) when your order is over $89 (excluding gift certificates and sales tax, if applicable). Customers who purchased this also purchased: Christmas Bells Are Ringing - OCTAVO - Mark Hayes Carl Fische... Lo, How A Rose E'er Blooming Sheet Music John Yarrington Abin... Noel, Sing Glad Noel! Sheet Music - Moderately Easy - 2 - Par... More Products Like This >> Please note there are only 5 copies available for shipment. More will be printed soon.Here is a listing of related products.
© 2015 Music44. All rights reserved.


text:
Note: To protect the privacy of our members, e-mail addresses have been removed from the archived messages. As a result, some links may be broken.
From: Judy Decker (jdecker_at_TeacherArtExchange) Date: Tue Jun 03 2003 - 17:01:13 PDT
Someone was looking for Native American Textiles....I don't remember which list so I am posting to all. I found this site from the Smithsonian today and added to my resources.
Textiles of the North American Southwest http://educate.si.edu/textiles/
Added to Americas Cultural Diversity page (click textiles at top): http://www.princetonol.com/groups/iad/lessons/middle/diversit.htm
If you find any good sites for Native Ameriacn Textiles - please post them and I will add them to my resources.
Judy Decker - Ohio email@example.com Incredible Art Department http://www.princetonol.com/groups/iad/ http://www.incredibleart.tk


text:
Superhero Store
Learn How
CBM Index
Punisher: War Zone Home
News Archive
My Choices For THE PUNISHER
As a change of pace from what I usually write, I want to give some ideas as to who could handle The Punisher. I give a few ideas as to who could do The Punisher justice in the MCU.
PUNISHER: WAR ZONE Director Lexi Alexander Denied EXPENDABELLES Meeting
Lexi Alexander, the director of
Punisher: War Zone
, has been considered a fan-favorite to helm the all-female
spin-off has revealed on her blog that producer Mark Gill would even meet with her about the opportunity. Come check it out.
100 Days of Superheroes- Day 75: The Punisher War Zone
More dark, more brutal, more dumb.
Lexi Alexander Director of
Punisher: War Zone
Reveals Freddie Prinze Jr. Was Almost Jigsaw
Lexi Alexander (Green Street Hooligans) gives an in-depth interview with Paul Scheer for his podcast, "How Did This Get Made?" Click the jump to learn about all the challenges that this director encountered while making the movie.
Looking back on Punisher: War Zone
Warning, I will nerd out horribly here.
PUNISHER (Ray Stevenson) : Character and Power Profile
Tidbits of information about the one man army, the PUNISHER.
Review: Punisher War Zone The Movie
This is one of those sit back, enjoy a cold beverage and salty snack of your choice and enjoy the fun and violence while shutting down some of those stressed brain cells kind of movie.
Pick up Punisher War Zone TODAY!
The ultra violent vision of Punisher that Marvel fans wanted to see is available NOW, March 17th. Here's what you can expect...
Punisher: War Zone Review
This is one of the most violent movies of 2008. Besides Saw V and Rambo 4, this movie had the craziest deaths and was funny as hell. If you have a fairly decent idea of the Punisher, you know he's ruthless and will destroy any kind of evil in his own special way.
Don't take it out on Ray Stevens!
Having been a fan of the Punisher Max comics and the Tom Jane version I was curious to see how the movie would be with out Tom Jane. Suprisingly I did not miss Tom Jane as Frank Castle...
Punisher: Turd Zone
This review will save you 2 hours of your life if you haven't seen the movie yet.
Punisher Review: Action makes up for the rest
Acting? Bad.... Dialogue? Bad..... Story? Bad.......but somehow the action, violence and, dare I say, "punishing" made it all seem......GREAT!
why i hated the punisher warzone movie
The Punisher movie bites. I prefer Dolph's film to this piece of #%$!
It was garbage. Gore fest meets B actors everywhere.
Punisher War Zone
The Movie Was Horrible
freaking awesome man
a little bit better than the first one
Everything about it is retarded, the story,the characters I mean come on this guy is not a hero he is a revenger and a murderer I can't beleive people like this movie.
Finally A True Punisher Movie
It's a movie. Not a film.
Punisher REBOOT delivers.
This ain't your Thomas Jane Punisher...and I LIKE IT!!
The movie will make your stomach turn not for the weak of heart.
Page 1 of 7
the punisher war zone music video
the punisher war zone music video
Punisher: War Zone (2008)
Punisher: War Zone DVD Trailer
More Videos
More Pictures


text:
dc.contributor.advisor | Hutt, Peter Barton | en_US |
dc.contributor.author | Fayad, Nihal | en_US |
dc.date.accessioned | 2012-06-07T20:36:16Z | |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Harmonizing Pharmaceutical Regulation Among the United States, the European Union, and Japan: The ICH Initiative (2003 Third Year Paper) | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8852171 | |
dc.description.abstract | The United States, the European Union and Japan comprise 75% of the world's pharmaceutical market and generate 90% of all pharmaceutical research. Recognizing the need for and benefits of harmonized testing standards the United States, the European Union and Japan formed a joint initiative between the industry and regulators called the International Conference on Harmonization (ICH). The ICH initiative has been underway for over a decade now. This paper will examine the disparate pharmaceutical regulatory regimes of the U.S., the EU, and Japan and will explore the ICH effort and its progress thus far. Part I of this paper overviews the current regulation of new pharmaceuticals in the United States, the European Union, and Japan. Based on these overviews, it will be apparent that the regulatory agencies of these three regions have already made some progress in harmonizing international standards. Part II explores the forces at work behind harmonization and discusses the potential benefits of pharmaceutical harmonization. Part III explains the ICH initiative including the mechanics of the ICH process and its implementation in the three ICH regions. Part IV of the paper addresses problems inherent in, and barriers to the achievement of the goals of the ICH. Finally, Part V of the paper discusses the accomplishments of the ICH thus far and evaluates its impact on the drug review process. | en |
dc.language.iso | en_US | en |
dash.license | LAA | en_US |
dc.subject | Food and Drug Law | en |
dc.subject | drug | en |
dc.subject | approval | en |
dc.subject | ICH | en |
dc.subject | Harmonization | en |
dc.subject | pharmaceutical regulation | en |
dc.title | Harmonizing Pharmaceutical Regulation Among the United States, the European Union, and Japan: The ICH Initiative | en |
dc.type | Paper (for course/seminar/workshop) | en_US |
dc.date.available | 2012-06-07T20:36:16Z |
Files | Size | Format | View |
Fayad.pdf | 264.9Kb |
View/ |
Fayad.rtf | 245.5Kb | RTF file |
View/ |
Fayad.html | 198.8Kb | HTML |
View/ |
Contact administrator regarding this item (to report mistakes or request changes)


text:
DC Comics have just confirmed to the LA Times Hero Complex blog that Grant Morrison and Rags Morales as the creative team on September's relaunch of Action Comics.
But, in a move that is either audacious or desperate — or a bit of both – DC Comics is making a break, at least in numbering, from the grand old series. In September, celebrated Scottish writer Grant Morrison and rising artist Ralph "Rags" Morales will start the series over with Action Comics No. 1, the 21st century version, which is one part of a huge initiative to a reach a new audience with a new interpretation of the Man of Steel and the DC Universe.
Bleeding Cool first mentioned Rags Morales in relation to this project a couple of weeks ago, alongside George Perez and designs for the new suit, while CBR mentioned Morrison's name in relation to this project last week.
The LA Times didn't bother to mention George Perez on Action Comics #1 however, nor Michael Green, Mike Johnson and Mahmud A. Asrar on Supergirl #1, nor Scott Lobdell on Superboy #1. But they do state that the full name of the Perez book is Superman: The Man Of Tomorrow. To come later on the DC Source blog I'm sure.
UPDATE: And there you go. Confirmation of Michael Green, Mike Johnson and Mahmud Asrar on Supergirl #1, George Perez only writing (and covering) Superman #1 (that's the full title) with Jesus Merino on art, and announcing R.B. Silva and Rob Lean as artists on Scott Lobdell's Superboy #1.


text:
Battlefield: Bad Company 2
The game is absolutely excellent. The single player has a very interesting story to it, as you play through the different areas of the world. But what is the most exciting is the multi-player. This game has been one of the best I've played and I am enjoying it very well. The multi-player lets me get a sense of teamwork and what might not be done if you do not cooperate. Even though there are many noobs, you can still enjoy the game by joining hardcore servers or other private servers that may not have too many of them. The weapon unlock system is great, how the more you play one class, the more benefits/weapons you get for the class, bringing the degree of fun to a next level. The vehicles and the ability to break buildings is stunning. This is one of the main factors that is putting battlefield bad company 2 somewhat better than modern warfare 2.