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Lets tally up any interest in this as the soon to be Stern title.
Probable next title up in September 2014
As much as I love The Walking Dead, I think Resident Evil would be a much better license for a pin.
I like the idea of an original zombie themed pin. Don't get me wrong, I like the Walking Dead, just don't see it as a great theme, the show is a bit too serious to be a theme for a machine that should make you laugh and feel good.
i can't wait for season 3 of Walking Dead this sunday!
so glad that the whole FARM saga is over. lookin' forward to the prison scenario.
a pin wouldn't be too shabby either
I can see it now. Woo SHOOT MY ZOMBIE FRIENDS MODE!! I'd love that. ALL MY FAMILY IS DEAD Multiball, hell yes... Smell the Rotting Flesh bonus multiplier... My Kid Is Missing In The Forest Full Of Zombies Hurry-up. Wait, no, all that sounds like it would suck.
Zombieland, Shaun of the Dead, Rob Zombie, Resident Evil, all those make a little more sense thematically.
Hm - Walking Dead was excellent stuff and I caught every episode religiously, I just don't think it would translate too well to pinball.
I would be stoked on a Walking Dead pin but if I had a choice I'd easily choose an overall Night/Dawn/Day Romero trilogy themed pin. For me Pinball always seems more ideal for classic property and no so much contemporary licenses, even though manufacturers always want the current popular license.
Walking Dead would be great; but Return of the Living Dead would be beyond awesome! Braaaaaaiiiiiiinssssss!!!!!!!!!
Get in line... If it is The Walking Dead, I will quit pinball and GIVE my games to charity! We watch the show, but it seems like it would be a VERY weak title.
black and white Walking Dead pin based on the comic ala Centaur would be sweet, but I'd pass on one based on the show. Same with Resident Evil - I'd buy one based on the video games in a second, but have zero interest in one based on the awful movies.
I think Jpop hit the nail on the head with Zombie Adventureland for a non serious take on Zombies, which seems to work. I like the Walking Dead series, but it's a very serious show with pretty much no light moments, and I can't see it translating well to a pin. Humorous Zombieland or Shaun of the Dead might work though.
I am all for a zombie title just not sure I want it to be Walking Dead.
Make it and make it good.. I will buy it.
I love the Walking Dead show, but it would seriously make for a bad pinball.
Now resident evil, or custom zombie themed pin would rock. Good luck to Jpop and his team for BHZA!!!
Mateui said:I can see it already - Where's Carl? Mode.
<Me> shoots himself in the HEAD! (So I won't regenerate.)
AkumaZeto said:the show is trash.
Wow! Thats harsh, haha I have a feeling you are in the minority on that one though.
underlord said:Zombie attacks...lol. Good one!
Return of the living Dead! My all time favorite! Had to get carded in the movie theater in 1984! SERIOUS R rating on that one!
"Oh no. Trash is taking her clothes off again!"
Rabid... weasels.
Blakesell said:If it has to be zombies, why not make it more current? World War Z is coming up with Brad Pitt, and the ladies love him, so they will love the pinball.. right?!?
The Walking Dead is already proven to be a hit, and its still running. Thats fairly current, I would say.
If anyone has any doubts on how cool the Zombie theme could translate into pin then check out Blindmankinds "Dead Hunters". One of my favorite Future Pin Tables.
ralfonso said:Am I the only one that's tired of zombies?
No, I was going to say the exact same thing.
'Walking Dead' premiere gets fall's biggest rating
(EW) -- The third season premiere of a basic cable zombie drama just delivered a bigger rating in the adult demo than any entertainment series this fall — including all broadcast shows.
Sunday night's third season premiere of "The Walking Dead" delivered a huge 10.9 million viewers for its first telecast. But what's really impressive is the show's adults 18-49 demo rating of a 5.8.
That's stunning.


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The lead-free, high purity pocket-sized solder dispenser for convenient rework and repair Precision manufactured activated rosin-core SAC solder Meets Fed. Spec. QQ-S-571E WRAP II Type RMA flux Ensures even, reliable solder connections Cleans and wets heavily tarnished copper surfaces RoHS compliant 1.0mm (0.04") diameter 3.18m 125" length
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20-3910 - Solder Flux
A flux for all metals, as effective as acid or chloride types but non-corrosive Solders even hard-to-solder metals such as aluminum, zinc-bases alloys, steel, etc. Ideal for soldering bus and ground wires to aluminum and steel chassis, to hermeti...
21-4719 - Crystal 400 Solder Wire - 63/37
Crystal™ 400 offers halide-free and 502 is the RMA version with 0.2% of halide Both offer a no-clean formulation giving crystal clear flux residues and minimal fume
200-040 - DeoxIT D5 Spray Contact Cleaner, 5% solution, 5 oz.
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200-385 - DeoxIt Rosin Flux Soldering Paste
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MCM Cat 57, Page 1166
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subset: commoncrawl


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Co.Design In Praise Of The Heroic Client When you think of the unusual juxtaposition of "client" and "hero," you might be forgiven for automatically conjuring up an image of Steve Jobs in his trademark jeans, running shoes, and black, long-sleeved mock turtleneck. After all, he almost single-handedly pulled his brand baby from the fires of mediocrity and propelled it back into the stratosphere (and beyond), utilizing his secret weapons of product innovation and design—both industrial and graphic. Read More » By Austin Howe
Co.Design In Praise Of The Heroic Client Long before Steve Jobs, there were other great patrons of design, among them Walter Paepcke, the marketing director of the Container Corporation of America. Read More » By Austin Howe


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Scrabble word: QUOTER
In which Scrabble dictionary does QUOTER exist?
Definitions of QUOTER in dictionaries:
- noun - a communicator (speaker or writer) who uses quotations
- adv - to repeat the words of [v QUOTED, QUOTING, QUOTES] : QUOTABLE [adj], QUOTABLY
There are 6 letters in QUOTER: E O Q R T U
Scrabble words that can be created with an extra letter added to QUOTER
All anagrams that could be made from letters of word QUOTER plus a wildcard: QUOTER?
Scrabble words that can be created with letters from word QUOTER
Images for QUOTER
Other Resources
SCRABBLE is the registered trademark of Hasbro and J.W. Spear & Sons Limited. Our scrabble word finder and scrabble cheat word builder is not associated with the Scrabble brand - we merely provide help for players of the official Scrabble game. All intellectual property rights to the game are owned by respective owners in the U.S.A and Canada and the rest of the world. Anagrammer.com is not affiliated with Scrabble. This site is an educational tool and resource for Scrabble & Words With Friends players.


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Any pattern suggestions for this dress? The inner top is actually a camisole that is part of the top and sewn into the elastic waistband, but I don't care that much about this part, I like the grecian draped top, extended sleeve and waist styling. You can see the dress better in the blue version.
Maybe you could start from this StyleArc pattern?
How about http://sewing.patternreview.com/cgi-bin/search.pl?CompanyID=51&search=1&summary=1 Very similar, but you would have to check to see how much ease there is to switch to a knit.
------height 5'2" bust 36, waist 31, hip 39. I have way too many yards to count, and I will never use them up, but I will die trying!
You would need to extend the shoulders (or use a small cap sleeve for the same look) and substitute a regular t-shirt back for the cowl back (I used my TNT pattern; at least one person has successfully used the pattern piece for non-drape front C as a back), but McCall 6069 is similar.
------http://theslapdashsewist.blogspot.com ================= 2007: purchased 115+, sewed 105+ So close to parity, yet so far Trying again in 2008 Yards purchased: 133 Yards sewn: Somewhere around 95 2009? I give up
Fantastic! A very close match. Thanks nicegirl, it is out of stock but I found it on Amazon.
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Class Details
by: ButtonFait...
by: Elizabeth ...
Pattern Details


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Marcos Breton: Sacramento isn't liberal on law and order
Though registered Republicans are disappearing in the capital region as they are across California, Sacramento County voters still lean right on one key issue: law and order.
The resounding victory of Anne Marie Schubert in the race to pick a new district attorney was just the latest example of a Sacramento taking a stand in favor of law enforcement.
"Sacramento would seem to be more conservative than the state as a whole on big-ticket crime and safety issues," said Robb Korinke, who runs GrassrootsLab, a California-based political research and data firm with business partner, Mike Madrid.
Two years ago, Sacramento County rejected a repeal of the death penalty by 53.7 percent to 46.3 percent, which was higher than the statewide average and very similar to numbers in the more traditionally conservative San Diego County.
Schubert was the co-chair of the campaign to beat back the death penalty repeal and she clearly paid no political price for it. The latest ballot count shows Schubert getting almost 60 percent of Tuesday's vote, which also proves she wasn't hurt for her ties to Jan Scully, the outgoing Sacramento DA who is stepping down after 20 years.
Schubert, a Republican and an 18-year prosecutor in Sacramento, faced state prosecutor Maggy Krell – the choice of Gov. Jerry Brown and state Attorney General Kamala Harris. Krell also got the strong backing of state Senate President Pro Tem Darrell Steinberg, who penned a rebuttal to the column I wrote last week that was critical of Krell.
No matter.
The three most powerful Democrats in a decidedly blue state were powerless to prevent Krell from being hammered at the polls. Another candidate, Todd Leras, ran a distant third.
"The voters of Sacramento County weren't going to let anyone come into their backyard and rule," a very happy Scully said Friday. "We're more real to them."
Scully was referring to the general support that local law enforcement leaders enjoy.
In the last four elections since winning her seat in 1994, Scully ran unopposed, a testament to her enduring popularity. Scott Jones ran unopposed Tuesday to be re-elected county sheriff.
Even in the very liberal city of Sacramento, voters overwhelmingly approved a sales tax hike in 2012 to bolster public safety programs and hire more cops.
This is not a new trend.
Korinke looked at data going back to elections in 2000 that showed Sacramento County consistently voting to the right of the state average on reforming California's "three-strikes" law, on victim's rights and the death penalty.
In about the same time frame, the proportion of Republican voters in Sacramento County fell from 36 percent in 2004 to 31 percent in 2014.
Meanwhile, registered Democrats remained roughly at 43.5 percent.
It's true that law and order should be a nonpartisan issue, but the Democrats tried to politicize the DA's race.
Schubert – and Scully by extension – was hit for pay hikes in the DA's Office, though the raises were established by labor contracts negotiated by the county.
They were accused of maintaining a jail-them-first attitude that needlessly filled jails with "low-level offenders."
Krell was an enthusiastic supporter of Brown's massive prison realignment plan that shifts some prisoners from the state to the counties.
Her talking points were straight from under the Capitol dome, but fell flat outside the manicured grounds where Brown, Harris and Steinberg rule the roost.
Much of it has to do with Sacramento's generally strong relationship with law enforcement and its particular penchant for electing local leaders.
"This is a town that likes to elect people from here," said Rob Stutzman, a GOP political operative who worked for former Gov. Arnold Schwarzenegger. "Krell was largely recruited by the party leadership."
Like Scully, Schubert grew up in the Sacramento area and was molded at Sacramento Catholic schools. She worked her way up through the local DA's Office as Scully did.
Sheriffs tend to promote locals or from within, as do Sacramento cops.
The exception was when Arturo Venegas was plucked from Fresno to run the Sacramento Police Department in 1993.
A very successful leader in many respects, Venegas nonetheless fought some in his ranks throughout his tumultuous tenure.
The succeeding three police chiefs have all been career, local cops.
It's that familiarity and a relative lack of scandal within law enforcement that has seen voters support cops and courts in Sacramento
"The voters are saying we're doing a good job. We're not perfect, but they are happy with the job we are doing," Scully said. "There was a lot of money thrown at a Democratic candidate in a nonpartisan election, but politics did not hijack experience – the voters didn't allow it."
Schubert comes from a big family clan with lots of friends, supporters and connections.
When some Democrats knocked her because her brother Frank ran Proposition 8, the 2008 campaign that temporarily banned same-sex marriage in California, the attacks went over like a lead balloon.
Schubert calmly countered by saying she loved her brother but disagreed with him. It made the politically active gay groups attacking her seem small.
Lots of families struggle as they work through the same-sex marriage issue, and none of the attacks against Schubert, who is openly gay, took into account how she must have been hurt by the experience, too.
Schubert never took the bait. She kept the focus on her experience, her roots and her advocacy for public safety.
At last count, her margin a victory was more than 30,000 votes – a strong, undeniable message about her and the county she will serve as DA.
About This Blog
Hello, my name is Marcos Breton, and I'm the news columnist with The Sacramento Bee. What's a columnist supposed to do? I'm supposed to make you think, make you laugh, make you mad or make you see an issue in a different way. I also write a weekly baseball column during the baseball season. I am a native of Northern California and the son of Mexican immigrants. I've been at The Bee for more than 20 years, and I love Sacramento.Contact Marcos Breton at email@example.com or 916-321-1096.
Twitter: @MarcosBreton
Marcos Breton
Join the Discussion
The Sacramento Bee is pleased to provide this opportunity to share information, experiences and observations about what's in the news. Some of the comments may be reprinted elsewhere on the site or in the newspaper. We encourage lively, open debate on the issues of the day, and ask that you refrain from profanity, hate speech, personal comments and remarks that are off point. Thank you for taking the time to offer your thoughts.


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Brussel Sprouts with Garlic, Sun-Dried Tomatoes and Pasta
Nutritional Info
- Servings Per Recipe: 2
- Amount Per Serving
- Calories: 281.3
- Total Fat: 14.0 g
- Cholesterol: 0.0 mg
- Sodium: 164.2 mg
- Total Carbs: 34.6 g
- Dietary Fiber: 5.3 g
- Protein: 7.7 g
View full nutritional breakdown of Brussel Sprouts with Garlic, Sun-Dried Tomatoes and Pasta calories by ingredient
Number of Servings: 2
All ingredients can be adjusted to your taste!
Marinate sun-dried tomatoes and garlic in olive oil. When ready, quarter brussel sprouts and saute in olive oil/garlic/tomato mix. Pasta can be boiling while the brussel sprouts are being cooked (no more than 10 minutes or they get mushy). Drain pasta and add to brussel sprouts. Saute for a few minutes (to taste) and serve.
Number of Servings: 2
Recipe submitted by SparkPeople user LI_VEGGIE.
Number of Servings: 2
Recipe submitted by SparkPeople user LI_VEGGIE.
Great Stories from around the Web
Rate This Recipe
Member Ratings For This Recipe
where are the ingredients? - 1/19/09
Reply from VEGANGIRL_NY (1/19/09)
Under "ingredient details". This was the first recipe I posted - sorry it didn't display in a more useful way. Not sure how to change it now! Good luck!


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You will enjoy:
For complete tranquillity and calm, nothing compares to an hour spent in our Isopod flotation tank. Bodytemperature saltwater suspends you effortlessly, allowing every muscle total relaxation. Research shows that not only is it an invaluable injury rehabilitation aid, it relieves pain and boosts the immune system. A boon to meditation, it's also proven to reduce stress, encourage endorphins and promote mental clarity.
Ockenden Manor Spa, a harmonious blend of modern design and nature's inspiration.
Exceptional facilities in a unique environment. The South's newest and most utopian spa, fed by its own underground spring.
Nestling in the warm green of the West Sussex countryside, Ockenden Manor Spa has been designed to create a haven from the hustle and bustle of everyday life. Purpose-built inside a 19th century walled garden, the contemporary airy structure contrasts and complements its neighbour, the Elizabethan Ockenden Manor, and shares it nine acres of parklands and gardens.
Mon - Fri | 7:00 am | - | 9:30 pm |
Sat - Sun | 8:00 am | - | 9:00 pm |


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Staff Reporter
Children of Jeeva Karunya Sangham in celebration mode
Rajahmundry: Every year on `Naraka Chaturti', a day before Deepavali, orphans of Jeeva Karunya Sangham look for donors who bring crackers for them. No such waiting for them this year. They are celebrating this Deepavali in a different way.
Actor Chiranjeevi Fans' Association of Rajahmundry and Police Mythri Sangham hit upon a unique idea and they approached Rajahmundry DSP P.H.D. Ramakrishna and sought his nod for implementing it. He readily agreed to it and gave some suggestions.
Later, they approached the sangham executive officer who agreed to send the children to the function arranged at Seethampeta junction on Friday.
Members of Chiranjeevi Fans' Association and the sangham arranged a Narakasura effigy made of crackers. Orphans of the karunya sangham were given a chance to burn the effigy.
Later, Mr. Ramakrishna distributed cracker packets to the boys for celebration on Deepavali day. Sweets were also distributed among the children.


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Article Preview
School: Sandusky denied job after background check
Published 12/07/2011, Associated Press
PHILADELPHIA (AP) -- A year and a half after an investigation began into Jerry Sandusky's contact with young boys, the former Penn State assistant football coach applied for a volunteer coaching job at a central Pennsylvania college but was denied the job after a background check.
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- Entertainment
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Escape Cinemas, Chennai
Escape Cinemas by Satyam is a luxury multiplex theater complex in Chennai with 8 cinema screens and 40,000 square feet area including private dining lounge in each screen - six small halls with a capacity of 100 and to large halls with capacity of 300 named blush, weave, spot, streak, plush, frame, carve and kites fitted with 3D screens.
Escape Cinemas Ticket Booking are available in many modes like touch screen kiosks, online ticket booking at thecinema.in, Phone booking at 4224 4224 or in person between 10:30am to 11 pm.
Escape Cinemas website also has info about special offers and promotions, facilities, careers, advertise, celebrations, news and events, latest movies, schedule, coming soon, release dates, special shows etc
Address: Escape Cinemas
3rd floor, Express Avenue Mall
Whiles Road, Royapettah
Chennai 600 014
Phone : 4224 4224
Email Customer Care : firstname.lastname@example.com
For Group Bookings in Chennai :email@example.com


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- All Photos (19)
- MLS Photos (19)
- Enlarge Photo
No Water Bill! Great location and in MOVE-IN Ready condition. Wood floors are in great condition and fireplace adds a warm touch. Hurry won't last long as mortgage may be cheaper than renting. Buyers may be eligible for House Charlotte program 7500. 00 towards down payment.
Population 39,702 | Median Household Income $55,044 | Median Years In Residence 8 |
Median Homeowner Age 35 | Households with Children 45.40% | Percent of Homes Rented 21.38% |
These are the closest schools to your requested location. Proximity does not guarantee enrollment eligibility. Please consult your real estate agent or school district to confirm the schools you are zoned to attend.
Please fill out this form to request more photos or more information regarding this property.


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Narrow your search
A new video recolours "Man of Steel" into "a Superman movie that looks like Superman!"
YouTube is the Web's de facto home for video. But 10 years ago, online video was anybody's game. As it celebrates a decade offering us everything from new celebrities to cat videos, YouTube has become a premier destination for content. Here's how it got there.
Which has the most apps? Which has the coolest features? Which one is the best? The most popular streamers all have their merits, so we'll help you decide which box is right for you.
BARCELONA -- Silent Circle's locked-down smartphone has a 5.5-inch display and sports an octa-core processor. Take a look in our hands-on photos.
In a new parody trailer for "50 Shades of Grey," it's not Lego minifigs getting down and dirty on camera. It's Christian Grey played by...Steve Buscemi? Caution: not safe for work.
CNET's Sumi Das gets the scoop from editor at large Tim Stevens ahead of Tuesday's Apple event. What do new leaked images of the iPhone 6 suggest? And will we see not just one, but two types of iWatch devices?
Lockheed's Squad Mission Support System is a prototype designed to assist combat units by autonomously hauling their gear. That's useful since the average soldier carries 130 pounds of gear.
Check out the highlights and big trends at this year's video game industry confab, from Halo to Amiibo to the Destiny demo.
No new hardware, but lots of apps and services make news on a day that underscored the evolutionary, not the revolutionary at Apple.
Details on pricing and availability are now official for Sony's 2015 televisions, and the company is focusing on 4K and charging a mint for many models. New for many sets is Android TV, while HDR arrives on the flagships.


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Casio Exilim EX-G1
Announced Nov 18, 2009
12 megapixels | 2.5″ screen | 38 – 114 mm (3×)
Ask a question in forums about the Casio Exilim EX-G1.
Ask a new question
This a which camera. The selector suggests a Samsung AQ100 or a Casio EX-G1 which are 3-4 years old. I'd like something that I can drop in my pocket with my keys and not worry about breaking it. I looked at the Olympus 'Tough' series. They aren't very tough: -10C is not something to brag about. I live in Wisconsin. :)
If someone could suggest a camera that will fit in a pocket with other items and can withstand the glovebox in winter I'd be grateful. It doesn't necessarily have to have...


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Can't find my graphics card
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Code covered by the BSD License
by Brenden Epps Brenden Epps (view profile) 19 files 138 downloads 1.5
05 Jun 2012 (Updated 07 Jun 2012)
DISPN(X,N) displays matrix X to N digits of precision.
| Watch this File
DISPN(X,N) displays matrix X to N digits of precision. See also DISP(X), which displays matrix X in the current screen format.
@Brenden: You have cared for a useful documentation by specifying the inputs, outputs, examples and a "See also" line. Unfortunately you do not follow the Matlab standards: H1 line after the function() line, the help text following, and the "See also" line containing the names of related functions. As MLINT warns, FPRINTF() is more efficient than DISP(SPRINTF()).
Which part of the one-liner in http://www.mathworks.com/matlabcentral/answers/40351-help-displaying-a-formatted-matrix-to-the-command-window you didn't like?
The updated version can now handle a vector N that specifies different numbers of digits for each column of X.
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"In 2009, the Yankees led the American League with an .876 on-base plus slugging mark out of the DH spot. By 2010, that number fell to .789, sixth in the league."
Should have kept Matsui (2009 DH).


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We recently had this super cute proposal and surprise beach engagement shoot sent over. What a lucky couple to have Cameron Ingalls capture their special moment!! Cameron sent us a little about his view and feeling on getting to be involved. He said, "The other day I had the great honor of witnessing my friend Ben Potter propose to the girl of his dreams. A few friends and I who helped prepare the surprise proposal hiked up an amazingly steep hill overlooking all of Avila Beach. We decorated and hid in the bushes waiting like game hunters with 4 guys and 4 cameras in position. Ben is part owner of CanaVP so he had his partner Andrew and some friends filming this amazing moment. I was lucky enough to snap the stills. You can see that my first shot of him on bended knee is well blocked by some trees. I was so nervous she would hear my shutter clicking that I kept good distance, at least, until he poured out his heart and asked her to be his wife. Andrew whipped up the lovely movie of the event below. What an amazing new years eve!" So cool! Thanks Cameron so much for sharing with us! You can follow Cameron on twitter and check out more of his work on his blog!
Engagement: Ben and Nichole from Ben Potter & Drew Barefoot on Vimeo.
so cute! i thought the birds were photoshopped until i saw the film, what a sweet guy!
obsessed with the video… and the colors of the images. Cameron is so good!
I love tillt shift photos.
LOVE this shoot and love Cameron Ingalls. who is this amazing video person??


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Prof Patrik Rorsman FRS FMedSci
Research Area: | Cell and Molecular Biology |
Scientific Themes: | Diabetes, Endocrinology & Metabolism |
Keywords: | diabetes, calcium, exocytosis, insulin, glucagon and somatostatin |
Web Links: |
A. Confocal image of mouse islet stained against insulin (red), glucagon (green) and somatostatin ...
Effects of elevating glucose from 1 to 6 to 20 mM on glucagon and insulin secretion measured using ...
A revised model for regulation of glucagon secretion by exogenous insulin involving insulin-induced ...
Insufficient insulin secretion represents an important facet of diabetes. Insulin is secreted from the ß-cells of the pancreatic islets when the blood glucose concentration rises above the normal ~5 mM. Precise knowledge about the cellular control and kinetics of insulin secretion is essential because type-2 diabetes involves the complete loss of rapid insulin secretion and a substantial reduction of sustained secretion. The loss of insulin secretion in diabetes is accompanied by defects in the release of the other islet hormones. For example, the regulation of glucagon release shows several abnormalities that exacerbate the metabolic consequences of insulin deficiency and type-2 diabetes is therefore best described as a multihormonal disorder.
The aim of our research is to explain how changes in the plasma glucose concentration via islet cell electrical activity and increases in the cytoplasmic Ca2+-concentration regulate exocytotic release of insulin as well as glucagon and somatostatin. Our work involves a combination of techniques to study secretion at the molecular, cellular and systemic levels. This requires sophisticated methodology to record the minute electrical currents flowing across biological membranes and secretion in individual cells at millisecond resolution. We also use optical techniques that allow us to monitor the movements of single secretory granules within the cell prior and during secretion.
These studies will promote our understanding of the fundamental processes that control insulin secretion under physiological conditions and determine the defects associated with clinical diabetes. Ultimately, our studies will allow the development of new diabetes therapies by identifying novel drug targets.
Name | Department | Institution | Country |
Prof Frances M Ashcroft | Department of Physiology | The University of Oxford | United Kingdom |
Erik Renstrom | Lund University | Sweden | |
Dr Patrick J Pollard (NDM) | Centre for Cellular and Molecular Physiology | University of Oxford | United Kingdom |
Cell Metab, 18 (6), pp. 871-882. Read abstract | Read more
2013. Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes, glucagon secretion is not suppressed at high glucose, exacerbating the consequences of insufficient insulin secretion, and is inadequate at low glucose, potentially leading to fatal hypoglycemia. The causal mechanisms remain unknown. Here we show that α cell KATP-channel activity is very low under hypoglycemic conditions and that hyperglycemia, via elevated intracellular ATP/ADP, leads to complete inhibition. This produces membrane depolarization and voltage-dependent inactivation of the Na(+) channels involved in action potential firing that, via reduced action potential height and Ca(2+) entry, suppresses glucagon secretion. Maneuvers that increase KATP channel activity, such as metabolic inhibition, mimic the glucagon secretory defects associated with diabetes. Low concentrations of the KATP channel blocker tolbutamide partially restore glucose-regulated glucagon secretion in islets from type 2 diabetic organ donors. These data suggest that impaired metabolic control of the KATP channels underlies the defective glucose regulation of glucagon secretion in type 2 diabetes. Hide abstract
Nature Reviews Endocrinology, 9 (11), pp. 660-669. Read abstract | Read more
2013. KATP channels and islet hormone secretion: New insights and controversiesATP-sensitive potassium channels (K ATP channels) link cell metabolism to electrical activity by controlling the cell membrane potential. They participate in many physiological processes but have a particularly important role in systemic glucose homeostasis by regulating hormone secretion from pancreatic islet cells. Glucose-induced closure of K ATP channels is crucial for insulin secretion. Emerging data suggest that K ATP channels also play a key part in glucagon secretion, although precisely how they do so remains controversial. This Review highlights the role of K ATP channels in insulin and glucagon secretion. We discuss how K ATP channels might contribute not only to the initiation of insulin release but also to the graded stimulation of insulin secretion that occurs with increasing glucose concentrations. The various hypotheses concerning the role of K ATP channels in glucagon release are also reviewed. Furthermore, we illustrate how mutations in K ATP channel genes can cause hyposecretion or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, and how defective metabolic regulation of the channel may underlie the hypoinsulinaemia and the hyperglucagonaemia that characterize type 2 diabetes mellitus. Finally, we outline how sulphonylureas, which inhibit K ATP channels, stimulate insulin secretion in patients with neonatal diabetes mellitus or type 2 diabetes mellitus, and suggest their potential use to target the glucagon secretory defects found in diabetes mellitus. © 2013 Macmillan Publishers Limited. All rights reserved. Hide abstract
Annu Rev Physiol, 75 (1), pp. 155-179. Read abstract | Read more
2013. Regulation of insulin secretion in human pancreatic islets.Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β cell is electrically excitable; in response to an elevation of glucose, it depolarizes and starts generating action potentials. The electrophysiology of mouse β cells and the cell's role in insulin secretion have been extensively investigated. More recently, similar studies have been performed on human β cells. These studies have revealed numerous and important differences between human and rodent β cells. Here we discuss the properties of human pancreatic β cells: their glucose sensing, the ion channel complement underlying glucose-induced electrical activity that culminates in exocytotic release of insulin, the cellular control of exocytosis, and the modulation of insulin secretion by circulating hormones and locally released neurotransmitters. Finally, we consider the pathophysiology of insulin secretion and the interactions between genetics and environmental factors that may explain the current diabetes epidemic. Hide abstract
Diabetes, 61 (7), pp. 1726-1733. Read abstract | Read more
2012. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secretory, biophysical, and ultrastructural features in relation to genetic risk profiles in diabetic and nondiabetic donors. Islets from donors with T2D exhibited impaired insulin secretion, which was more pronounced in lean than obese diabetic donors. We assessed the impact of 14 disease susceptibility variants on measures of glucose sensing, exocytosis, and structure. Variants near TCF7L2 and ADRA2A were associated with reduced glucose-induced insulin secretion, whereas susceptibility variants near ADRA2A, KCNJ11, KCNQ1, and TCF7L2 were associated with reduced depolarization-evoked insulin exocytosis. KCNQ1, ADRA2A, KCNJ11, HHEX/IDE, and SLC2A2 variants affected granule docking. We combined our results to create a novel genetic risk score for β-cell dysfunction that includes aberrant granule docking, decreased Ca(2+) sensitivity of exocytosis, and reduced insulin release. Individuals with a high risk score displayed an impaired response to intravenous glucose and deteriorating insulin secretion over time. Our results underscore the importance of defects in β-cell exocytosis in T2D and demonstrate the potential of cellular phenotypic characterization in the elucidation of complex genetic disorders. Hide abstract
Diabetes, 59 (9), pp. 2198-2208. Read abstract | Read more
2010. Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.OBJECTIVE: To document the properties of the voltage-gated ion channels in human pancreatic alpha-cells and their role in glucagon release. RESEARCH DESIGN AND METHODS: Glucagon release was measured from intact islets. [Ca(2+)](i) was recorded in cells showing spontaneous activity at 1 mmol/l glucose. Membrane currents and potential were measured by whole-cell patch-clamping in isolated alpha-cells identified by immunocytochemistry. RESULT: Glucose inhibited glucagon secretion from human islets; maximal inhibition was observed at 6 mmol/l glucose. Glucagon secretion at 1 mmol/l glucose was inhibited by insulin but not by ZnCl(2). Glucose remained inhibitory in the presence of ZnCl(2) and after blockade of type-2 somatostatin receptors. Human alpha-cells are electrically active at 1 mmol/l glucose. Inhibition of K(ATP)-channels with tolbutamide depolarized alpha-cells by 10 mV and reduced the action potential amplitude. Human alpha-cells contain heteropodatoxin-sensitive A-type K(+)-channels, stromatoxin-sensitive delayed rectifying K(+)-channels, tetrodotoxin-sensitive Na(+)-currents, and low-threshold T-type, isradipine-sensitive L-type, and omega-agatoxin-sensitive P/Q-type Ca(2+)-channels. Glucagon secretion at 1 mmol/l glucose was inhibited by 40-70% by tetrodotoxin, heteropodatoxin-2, stromatoxin, omega-agatoxin, and isradipine. The [Ca(2+)](i) oscillations depend principally on Ca(2+)-influx via L-type Ca(2+)-channels. Capacitance measurements revealed a rapid (<50 ms) component of exocytosis. Exocytosis was negligible at voltages below -20 mV and peaked at 0 mV. Blocking P/Q-type Ca(2+)-currents abolished depolarization-evoked exocytosis. CONCLUSIONS: Human alpha-cells are electrically excitable, and blockade of any ion channel involved in action potential depolarization or repolarization results in inhibition of glucagon secretion. We propose that voltage-dependent inactivation of these channels underlies the inhibition of glucagon secretion by tolbutamide and glucose. Hide abstract
Cell Metab, 11 (6), pp. 543-553. Read abstract | Read more
2010. GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.Glucagon secretion is inhibited by glucagon-like peptide-1 (GLP-1) and stimulated by adrenaline. These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. The expression of GLP-1 receptors in alpha cells is <0.2% of that in beta cells. The GLP-1-induced suppression of glucagon secretion is PKA dependent, is glucose independent, and does not involve paracrine effects mediated by insulin or somatostatin. GLP-1 is without much effect on alpha cell electrical activity but selectively inhibits N-type Ca(2+) channels and exocytosis. Adrenaline stimulates alpha cell electrical activity, increases [Ca(2+)](i), enhances L-type Ca(2+) channel activity, and accelerates exocytosis. The stimulatory effect is partially PKA independent and reduced in Epac2-deficient islets. We propose that GLP-1 inhibits glucagon secretion by PKA-dependent inhibition of the N-type Ca(2+) channels via a small increase in intracellular cAMP ([cAMP](i)). Adrenaline stimulates L-type Ca(2+) channel-dependent exocytosis by activation of the low-affinity cAMP sensor Epac2 via a large increase in [cAMP](i). Hide abstract
Cell Metab, 10 (6), pp. 455-465. Read abstract | Read more
2009. Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.Long-term (72 hr) exposure of pancreatic islets to palmitate inhibited glucose-induced insulin secretion by >50% with first- and second-phase secretion being equally suppressed. This inhibition correlated with the selective impairment of exocytosis evoked by brief (action potential-like) depolarizations, whereas that evoked by long ( approximately 250 ms) stimuli was unaffected. Under normal conditions, Ca(2+) influx elicited by brief membrane depolarizations increases [Ca(2+)](i) to high levels within discrete microdomains and triggers the exocytosis of closely associated insulin granules. We found that these domains of localized Ca(2+) entry become dispersed by long-term (72 hr), but not by acute (2 hr), exposure to palmitate. Importantly, the release competence of the granules was not affected by palmitate. Thus, the location rather than the magnitude of the Ca(2+) increase determines its capacity to evoke exocytosis. In both mouse and human islets, the palmitate-induced secretion defect was reversed when the beta cell action potential was pharmacologically prolonged. Hide abstract
Diabetes, 57 (6), pp. 1618-1628. Read abstract | Read more
2008. Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.OBJECTIVE: To characterize the voltage-gated ion channels in human beta-cells from nondiabetic donors and their role in glucose-stimulated insulin release. RESEARCH DESIGN AND METHODS: Insulin release was measured from intact islets. Whole-cell patch-clamp experiments and measurements of cell capacitance were performed on isolated beta-cells. The ion channel complement was determined by quantitative PCR. RESULTS: Human beta-cells express two types of voltage-gated K(+) currents that flow through delayed rectifying (K(V)2.1/2.2) and large-conductance Ca(2+)-activated K(+) (BK) channels. Blockade of BK channels (using iberiotoxin) increased action potential amplitude and enhanced insulin secretion by 70%, whereas inhibition of K(V)2.1/2.2 (with stromatoxin) was without stimulatory effect on electrical activity and secretion. Voltage-gated tetrodotoxin (TTX)-sensitive Na(+) currents (Na(V)1.6/1.7) contribute to the upstroke of action potentials. Inhibition of Na(+) currents with TTX reduced glucose-stimulated (6-20 mmol/l) insulin secretion by 55-70%. Human beta-cells are equipped with L- (Ca(V)1.3), P/Q- (Ca(V)2.1), and T- (Ca(V)3.2), but not N- or R-type Ca(2+) channels. Blockade of L-type channels abolished glucose-stimulated insulin release, while inhibition of T- and P/Q-type Ca(2+) channels reduced glucose-induced (6 mmol/l) secretion by 60-70%. Membrane potential recordings suggest that L- and T-type Ca(2+) channels participate in action potential generation. Blockade of P/Q-type Ca(2+) channels suppressed exocytosis (measured as an increase in cell capacitance) by >80%, whereas inhibition of L-type Ca(2+) channels only had a minor effect. CONCLUSIONS: Voltage-gated T-type and L-type Ca(2+) channels as well as Na(+) channels participate in glucose-stimulated electrical activity and insulin secretion. Ca(2+)-activated BK channels are required for rapid membrane repolarization. Exocytosis of insulin-containing granules is principally triggered by Ca(2+) influx through P/Q-type Ca(2+) channels. Hide abstract
PLoS Biol, 5 (6), pp. e143. Read abstract | Read more
2007. A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed to neuronal control, paracrine control by neighbouring beta cells, or to an intrinsic glucose sensing by the alpha cells themselves. We examined hormone secretion and Ca(2+) responses of alpha and beta cells within intact rodent and human islets. Glucose-dependent suppression of glucagon release persisted when paracrine GABA or Zn(2+) signalling was blocked, but was reversed by low concentrations (1-20 muM) of the ATP-sensitive K(+) (KATP) channel opener diazoxide, which had no effect on insulin release or beta cell responses. This effect was prevented by the KATP channel blocker tolbutamide (100 muM). Higher diazoxide concentrations (>/=30 muM) decreased glucagon and insulin secretion, and alpha- and beta-cell Ca(2+) responses, in parallel. In the absence of glucose, tolbutamide at low concentrations (<1 muM) stimulated glucagon secretion, whereas high concentrations (>10 muM) were inhibitory. In the presence of a maximally inhibitory concentration of tolbutamide (0.5 mM), glucose had no additional suppressive effect. Downstream of the KATP channel, inhibition of voltage-gated Na(+) (TTX) and N-type Ca(2+) channels (omega-conotoxin), but not L-type Ca(2+) channels (nifedipine), prevented glucagon secretion. Both the N-type Ca(2+) channels and alpha-cell exocytosis were inactivated at depolarised membrane potentials. Rodent and human glucagon secretion is regulated by an alpha-cell KATP channel-dependent mechanism. We propose that elevated glucose reduces electrical activity and exocytosis via depolarisation-induced inactivation of ion channels involved in action potential firing and secretion. Hide abstract
Nat Cell Biol, 9 (4), pp. 453-460. Read abstract | Read more
2007. R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.Pancreatic islets have a central role in blood glucose homeostasis. In addition to insulin-producing beta-cells and glucagon-secreting alpha-cells, the islets contain somatostatin-releasing delta-cells. Somatostatin is a powerful inhibitor of insulin and glucagon secretion. It is normally secreted in response to glucose and there is evidence suggesting its release becomes perturbed in diabetes. Little is known about the control of somatostatin release. Closure of ATP-regulated K(+)-channels (K(ATP)-channels) and a depolarization-evoked increase in cytoplasmic free Ca(2+) concentration ([Ca(2+)](i)) have been proposed to be essential. Here, we report that somatostatin release evoked by high glucose (>or=10 mM) is unaffected by the K(ATP)-channel activator diazoxide and proceeds normally in K(ATP)-channel-deficient islets. Glucose-induced somatostatin secretion is instead primarily dependent on Ca(2+)-induced Ca(2+)-release (CICR). This constitutes a novel mechanism for K(ATP)-channel-independent metabolic control of pancreatic hormone secretion. Hide abstract
Cell Metab, 4 (4), pp. 283-290. Read abstract | Read more
2006. Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.Exocytosis of secretory vesicles begins with a fusion pore connecting the vesicle lumen to the extracellular space. This pore may then expand or it may close to recapture the vesicle intact. The contribution of the latter, termed kiss-and-run, to exocytosis of pancreatic beta cell large dense-core vesicles (LDCVs) is controversial. Examination of single vesicle fusion pores demonstrated that rat beta cell LDCVs can undergo exocytosis by rapid pore expansion, by the formation of stable pores, or via small transient kiss-and-run fusion pores. Elevation of cAMP shifted LDCV fusion pore openings to the transient mode. Under this condition, the small fusion pores were sufficient for release of ATP, stored within LDCVs together with insulin. Individual ATP release events occurred coincident with amperometric "stand alone feet" representing kiss-and-run. Therefore, the LDCV kiss-and-run fusion pores allow small transmitter release but likely retain the larger insulin peptide. This may represent a mechanism for selective intraislet signaling. Hide abstract
Nature, 432 (7014), pp. 226-230. Read abstract | Read more
2004. A pancreatic islet-specific microRNA regulates insulin secretion.MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression. Several miRNAs in animals exhibit tissue-specific or developmental-stage-specific expression, indicating that they could play important roles in many biological processes. To study the role of miRNAs in pancreatic endocrine cells we cloned and identified a novel, evolutionarily conserved and islet-specific miRNA (miR-375). Here we show that overexpression of miR-375 suppressed glucose-induced insulin secretion, and conversely, inhibition of endogenous miR-375 function enhanced insulin secretion. The mechanism by which secretion is modified by miR-375 is independent of changes in glucose metabolism or intracellular Ca2+-signalling but correlated with a direct effect on insulin exocytosis. Myotrophin (Mtpn) was predicted to be and validated as a target of miR-375. Inhibition of Mtpn by small interfering (si)RNA mimicked the effects of miR-375 on glucose-stimulated insulin secretion and exocytosis. Thus, miR-375 is a regulator of insulin secretion and may thereby constitute a novel pharmacological target for the treatment of diabetes. Hide abstract
EMBO J, 22 (15), pp. 3844-3854. Read abstract | Read more
2003. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.Insulin is secreted from pancreatic beta cells in response to an elevation of cytoplasmic Ca(2+) resulting from enhanced Ca(2+) influx through voltage-gated Ca(2+) channels. Mouse beta cells express several types of Ca(2+) channel (L-, R- and possibly P/Q-type). beta cell-selective ablation of the gene encoding the L-type Ca(2+) channel subtype Ca(v)1.2 (betaCa(v)1.2(-/-) mouse) decreased the whole-cell Ca(2+) current by only approximately 45%, but almost abolished first-phase insulin secretion and resulted in systemic glucose intolerance. These effects did not correlate with any major effects on intracellular Ca(2+) handling and glucose-induced electrical activity. However, high-resolution capacitance measurements of exocytosis in single beta cells revealed that the loss of first-phase insulin secretion in the betaCa(v)1.2(-/-) mouse was associated with the disappearance of a rapid component of exocytosis reflecting fusion of secretory granules physically attached to the Ca(v)1.2 channel. Thus, the conduit of Ca(2+) entry determines the ability of the cation to elicit secretion. Hide abstract
Nature, 363 (6427), pp. 356-358. Read abstract | Read more
1993. Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells.How does cyclic AMP potentiate insulin secretion from pancreatic islet beta-cells? This question is fundamental to understanding how hormones such as glucagon, which elevates cAMP, stimulate insulin secretion and so contribute to the normal secretory response of the islet. It is well established that a rise in the cytoplasmic Ca2+ concentration ([Ca2+]i) is essential for insulin secretion and therefore cAMP has been proposed to act by elevating [Ca2+]i. But studies on permeabilized beta-cells indicate that cAMP increases insulin release even when [Ca2+]i is held constant. We have used microfluorimetry and the patch-clamp technique to measure changes simultaneously in Ca2+ currents, [Ca2+]i and exocytosis in a single beta-cell in response to cAMP. We show here that cAMP, through activation of protein kinase A, increases Ca(2+)-influx through voltage-dependent L-type Ca2+ channels, thereby elevating [Ca2+]i and accelerating exocytosis. More importantly, cAMP also promotes insulin release by a direct interaction with the secretory machinery, which accounts for as much as 80% of its effect. Hide abstract


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Vice President M Hamid Ansari is leading the Government of India delegation in Riyadh to convey condolences for the passing away of Saudi Arabia's King Abdullah.
A US delegation has arrived here for the first time since the two neighbouring countries decided to restore diplomatic ties last month, Xinhua reported Sunday.
Former Indian cricket captain Sunil Gavaskar met Prime Minister Narendra Modi here on Saturday.
North Korea will hold new talks with South Korea about taking part in the Incheon Asian Games after slashing the size of its delegation, a government official said on Friday.
Defence Minister A K Antony is not part of Prime Minister Manmohan Singh`s delegation that will hold talks with British Prime Minister David Cameron.
A high-level IAEA delegation is to visit Iran from Jan 29-31 to discuss issues it has over Tehran`s nuclear programme.
Bihar youth Congress would petition Union Home Minister P Chidambaram Rail Minister Trivedi seeking to rechristen the names of four R`way stations.
A high-level delegation, which went to see the site of the proposed AMU centre in north Maharashtra, had to return without inspecting the spot.
A delegation, consisting of two former Gujarat ministers, is meeting President Pratibha Patil in Delhi.
Sri Lanka is opposed to the UNHRC sessions taking up the panel report.
In the backdrop of controversies over land acquisition, Congress leader Rahul Gandhi led a delegation of young MPs to PM Manmohan Singh, seeking introduction of the new Land Bill in the current session of Parliament.
PM Manmohan Singh is understood to have assured a Congress delegation from Orissa on Wednesday that the Centre would respond positively on any report that judicial commission on mining.
A delegation of Himalayan Buddhists led by HE Tsona Gontse Rinpoche met PM Manmohan Singh at his office at New Delhi to discuss proposals for the welfare of the large number of Buddhism followers in the Himalayan belt.
A delegation of Himalayan Buddhists led by HE Tsona Gontse Rinpoche met Prime Minister Manmohan Singh at his office at New Delhi.
A delegation of Congress on Thursday met Uttar pradesh Governor B L Joshi and demanded a CBI probe into the death of a five-year-old girl, whose body was recovered without a kidney on June 11.
A delegation of TDP leaders and MLAs from Telangana region of Andhra Pradesh today met President Pratibha Patil and demanded the Centre immediately initiate steps for formation of a separate Telangana state.
An all-party delegation from Karnataka led by Chief Minister B S Yeddyurappa on Monday met Prime Minister Manmohan Singh to demand special status for the Hyderabad-Karnataka area.
For the first time ever, a delegation of tribals met Finance Minister Pranab Mukherjee and demanded allocation for the tribal populace in the Union budget to be presented next month.
A delegation of Trinamool Congress leaders on Thursday met Prime Minister Manmohan Singh and conveyed to him that West Bengal`s ruling CPI-M was allegedly misusing the Central security forces deployed against Maoists.
A delegation of parliamentarians and civil society activists on Sunday favoured resumption of composite dialogue with Pakistan and talks with separatist leaders in the Valley to resolve the Kashmir issue.
Major earthquake rattles Nepal, India
Day in Pics: 26th April
Showbiz World - April 26, 2015


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I'm a part-time filmmaker and full-time entrepreneur. Check out my film, The Prospects, or my website, Therapick, where you can watch video clips of therapists before you choose one. I'm a quiet, competent, friendly guy and I'll probably be out at work or exploring the city most of the time.
David has completed online and offline ID verification.
When my brother and I arrived at his place, David kindly welcomed us and answered all our immediate needs. The apartment was even better in person than it looked in photos. Both the couch and bed were extremely comfortable. The location is fantastic and allows for easy bus transportation if you don't have a car. I would highly recommend staying here for the price.
David and his girlfriend were the perfect couple to deal with. Kind and attentionate, they made sure we had a lovely stay at their apartment. The place was impeccable and homie - our hosts even left us cookies with their welcome letter! Sweet people... Thank you again.
Super nice professional young man.
You're the man David. Hope you had a great time and enjoyed your stay. I know, I know. Im working on the table. I just cant seem to find one that I like lol. No worries, anytime pal. Thanks!


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Robert HILL
Robert HILL
Robert married Sandra BERGHAN, daughter of William Aubrey BERGHAN and Olive THOMAS. (Sandra BERGHAN was born on 2 Mar 1952 in New Zealand.) |
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The 752-page book, which was written half a century ago by the late U.S. chef, author and television personality, has earned renewed attention thanks to the popularity of the blog, book and film, "Julie & Julia."
The Times said "Mastering the Art" will rank No. 1 on its best-seller list next week in the advice and how-to category.
Nielsen BookScan said 22,000 copies of the book were sold in the most recent week tracked. Its publisher, Alfred A. Knopf, said that is more copies sold in any full year since "Mastering" was first released.
Little, Brown reportedly has reprinted Julie Powell's 2005 memoir "Julie & Julia," which is about how she cooked every recipe in Child's book, 13 times this year.
"This was a secret dream that the movie would sell a lot of books," Nora Ephron, the film's writer and director, told The Times. "I'm completely delighted that people are walking out of the multiplex and into the bookstore."


text: We can assume that . Let . Let be the map and and leaves everything else fixed. Let be the map . Show that . Now if then it has a finite subseteq with . The functions on can be regarded as being embedded in . Thus, since it is not commutative on it is not commutative on .


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Turn your breakdowns into breakthroughs!!Face each day with courage and strength as T.D. Jakes empowers you with the wisdom of his years of walking closely with the Lord. Your challenges will turn into triumphs...
Come along with P.C. Nelson as he leads you on a journey into God's Word to discover 16 timeless Pentecostal truths. Nelson's down-to-earth, conversational tone takes you step-by-step through Scripture to carefully...
Let the Spirit live inside you!Are you hungry for an encounter with Jesus? Do you want to make an impact on the world? In this power-packed book, Bill Johnson discusses how you can be a person who hosts the...
In this book, Wigglesworth describes the role and function of spiritual gifts, and he provides important spiritual safeguards for the proper exercise of these manifestations of the Holy Spirit. By discovering...
The gifts and ministries of the Holy Spirit function with greatest accuracy through people who understand them. Discover how you can be included in the great outpouring of God's Spirit.
Eighteen sermons on divine healing. Topics include people suffering from broken limbs, appendicitis, alcoholism, demon possession, addictions, and tuberculosis. Studies spiritual gifts, the Baptism, prophecy,...
This illustrated version of the timeless classic has been arranged by Dian Layton and beautifully illustrated by JoAnn Edington. It tells the story of Much-Afraid and her journey to the High Places with the...
International prophetic leader gives believers a basic handbook for understanding prophetic ministry, prophetic callings, and the access all Christians have to God's gift of prophecy.
A sensitive and realistic look at the spiritual life andpractices of the Amish
This second book by the authors of the award-winning AmishGrace sheds further light on the Amish, this time on theirfaith, spirituality,...
God has more for us than what we are experiencing. We have all limited God in our lives at some point in one way or another. Fear of success, fear of persecution and imaginations are all ways that we limit God....
Luther popularized this work by a 14th-century author who focuses on the "divine life," which is directed or guided by the "true light" of God. It offers insightful spiritual advice relevant to all Christians....
Discover what your dreams are telling you with this personal guide to hearing God through dreams and visions from prophetic leader Laura Harris Smith.
Book 5 of the Amish-Country Mysteries
Three young friends disappear while traveling on their Amish rite of passage, Rumschpringe, or wild days. In a race against the clock, the sheriff must find a murderer and...
The harvest is past, the summer has ended, and we are not saved (Jeremiah 8:20).Bishop T.D. Jakes focuses on the problems plaguing the United States of America and addresses issues that many would rather not...
Faith is a gift of God that is available to all who will receive it. Smith Wigglesworth was a man who simply took God at His word, and God used his faith as a model for others. Here is inspiration for anyone...
Mary Baxter, the best-selling author of A Divine Revelation of Hell and A Divine Revelation of Heaven, gives a unique perspective into the angelic and demonic realms. In vivid detail, she describes her encounters...
Nine Days in Heaven relates the vision of twenty-five-year-old Marietta Davis more than 150 years ago, where she was shown the beauties of heaven and the horrors of hell.
Full of inspiring stories of breakthrough, Breaking the Bonds of Evil examines the deliverance ministry of Jesus and trains believers to confidently walk out their freedom.
Each book introduces every chapter's theme, author, and general time period and follows with a fast-reading outline of the book, noting cultural traditions and other influences.
Each book introduces every chapter's theme, author, and general time period and follows with a fast-reading outline of the book, noting cultural traditions and other influences.


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Late 60s -Indian Sportswear- Mens tan and brown horizontal stripe print background acrylic knit, pullover mod shirt with rounded neckline, rib knit box cut hem and raglan seamed short sleeves.
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Slimer™ can run but he cannot hide… not when your spectral stalking supplies include our Ecto Goggles! Inspired by the iconic Ghostbusters™ film series and developed with Sony Entertainment, the "one size fits most humans" design allows you to see four stop-motion animations created from Mattel's 6" scale Slimer™ figure.
If you've got our Ghostbusters™ PKE Meter, just plug the included "echo locator" piece into the meter and you'll unlock additional animations of the Library Ghost and a proton stream in the goggles. Crank up the sound on the meter and the faster those ghosts move in the goggles! (Slimer™ appears with or without the PKE Meter.) Also includes stickers so you can customize the Ecto Goggles or leave them plain, as originally designed by Egon.
TM & © 2013 Columbia Pictures Industries, Inc. All rights reserved.
You must be 18 or older to purchase this product.


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Graduate Student at University of Bologna
Naina has completed online and offline ID verification.
Naina è una ragazza molto gentile ed educata, in sintesi è un'ospite molto affidabile.
Naina e sua sorella sono state buone ospiti e hanno lasciato l'appartamento in buone condizioni... Le ospiterei ancora senza problemi....
Naina is a very beautiful and kind person. She and her friend were kind, reserved and pleasant people. It was a pleasure for me to have as my guests in my home. Castalda
It was a pleasure to host Naina and her friend, although we only met very briefly she was extremely polite, tidy and friendly. I hope I'll see her again soon!


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Boston police investigate the discovery of two suspicious backpacks at the finish line at the Boston Marathon Tuesday evening.
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I have had two breast augmentations, and recently I was laying on the couch when my son ran as jumped on my chest. My boon on the left side has been hurting a little over 3 weeks could something possibly be wrong? Any kind of pressure that gets put on it makes it hurt worse
Pain in Left Boob, Child Jumped and Landed on Chest, Pain Still After Three Weeks, I Do Have a Boob Job, is This Serious?
Doctor Answers 2
Unfortunately, all we can do from an internet forum is speculate. Because your symptoms have persisted for 3 weeks, I would recommend following up with your plastic surgeon to make sure everything looks okay.
Web reference: http://www.drbogue.com
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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Shaheer sheikh and Soumya Seth
Shaheer sheikh and Soumya Seth in Navya TV Show
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Anant N Navya. :)))))))))))
miss u Shamya...pls come back soon together :)
*teary eyes* The BEST couple in telly history!!
U r the BEST! really very PROUD to be ur fan!! Love u a lottt se bhi zyada <3
ye din phir kab ayenge.missing them so much:(((
Edited on:08 November 2012 at 1:53pm
Rab ne bana di jodi :) Love u Anya <3
Edited on:20 May 2013 at 1:06pm
The sweetest and so much lovable couple ,want to c them again in another show
Edited on:22 August 2012 at 5:49am


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Does the Purchaser Experience display need to be updated?
Alright, this is probably a long time coming. Now that we are on Woot 4.0, it is time to move past the old measuring stick of First Woot, Second Woot, less than 10, less than 25 and greater than 25. With the amount of people with black boxes, it is time to add greater than 100. I did put this in as Beta Feedback but I want to know what the community thinks. Is it time that those with 100+ Woots be identified for their purchasing decisions?
I just hit 50 purchases in the last woot-off, and upgraded to a purple square, so your numbers aren't quite right.
@sully51: Let me restate, sorry for the confusion. Also, thanks for the post on why things are the way they are. I always did wander how they picked 25 as the dividing level.
With the amount of people with black boxes (purchases over 100), it is time to add greater than 100. (There seem to be quite a few Wooters with purchases over 100 that there would be several that would be purchasing each item.)
It's actually only a color/mark identifying the most active here. I personally don't have a problem with the current system, and I'm posting with a black triangle/square here. +1 on the question btw.
It doesn't matter to me, I love Woot either way. I'm sure there are a bunch of people though who have a ton of Woots that would love to be recognized for it.
I realize this question hasn't had any activity in 2 months, but why bother making a new question when mine is essentially the same. I was just thinking about the black square and how when it was first changed I had to make a few more purchases to achieve it again. Now though, I'm in 200+ territory but everyone with 100+ is sharing my black square. I agree that since the site design has changed maybe it's time to change the thresholds required to attain certain squares, or add new higher tiers of squares that previously were only dreamed of.


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Minister to visit Northern Cape schools
Comment on this storyJohannesburg - Basic Education Minister Angie Motshekga will visit the Northern Cape where 41 schools have been closed due to intimidation, her office said on Friday.
Spokesman Panyaza Lesufi said Motshekga planned to visit the district on Wednesday, after receiving an 18-page report compiled by an education task team.
A total of 41 of the 65 schools in the Johan Taolo Gaetsewe district municipality, which includes Kuruman, have been closed since June because of residents intimidating children. Locals had been protesting over a lack of tarred roads in the municipality.
Children in the province had still not returned to schools, provincial education spokesman Sydney Stander said on Wednesday.
Stander said meetings with church leaders were being planned to encourage parents to send their children back to school.
The Police Minister Nathi Mthethwa visited Olifantshoek on Monday, where he met residents who had demanded the mayor's resignation amid accusations of corruption.
"The fundamental issue is that learners must return to school. That is the ultimate goal of the minister's intervention," Mthethwa's spokesman Zweli Mnisi said.
Mnisi said resolving the issues in the town was a collective effort.
Following discussions chaired by Mthethwa, it was agreed that a task team including community representatives, local government and education officials, and the police, be formed to resolve tensions in Olifantshoek. - Sapa
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30th July 2011, 01:39 AM | #41 |
diyAudio Member
Join Date: Jan 2006
Location: Sydney
Additional Note, i had been using 3.9ohm load across the terminals during test, and replaced them with some speakers, now the temps have dropped to ~33C with that easier load.
30th July 2011, 01:51 AM | #42 |
diyAudio Member
Join Date: Sep 2004
Location: Minneapolis, Minnesota, USA
Good deal, sounds like it's under control. With two chips running in parallel you'll be able to drive loads as low as 2 ohms in theory, and of course it depends on how efficient the heat sink is. Have fun!
Mike |
30th July 2011, 01:57 AM | #43 |
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cheers mate. I've just tested the DC offset of a couple other retail amps i've bought, and they are measuring +15mV on each channel, i too have adjusted those down to ~0 fairly easily enough. Thanks everyone for the direction and advise, i'm sure i'll be here soon asking a few more questions.
rick |
30th July 2011, 05:53 PM | #44 |
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Join Date: Dec 2009
Location: Bay City, Michigan
Richard, I have two of these - one working at 17VDC on all three chips. The other one is producing some oscillation that makes the DC readings fluctuate wildly. I couldn't tell from your posts if you actually installed the 100K pots and/or added a second surface mount resistor.
I bought the boards only from Jim's Audio on eBay and he sent a diagram. I'm going to do the two chip mod and hope I get as good results as you.
Bob M. "Arrange Whatever Pieces Come Your Way." Last edited by bcmbob; 30th July 2011 at 06:16 PM. |
30th July 2011, 11:18 PM | #45 |
diyAudio Member
Join Date: Jan 2006
Location: Sydney
Hi bob,
thats the very same amp circuit i have, one thing i can see that is different is the C1 capacitor. On that schematic it's rated at 10uF, i have a 4.7uF used on my board. I had removed the centre chip from each board to make lowering the DC offset abit easier and stable to adjust and maintain between the chips. There was too much varience between three chips that was unable to be controlled. One thing i have observed during warm up, warm down is, what ever change in DC offset one chip has, it is countered on the other. So now i would recommend replacing those 50K pots to 100K, i havn't done it yet, but my guess is that a higher range pot, you may get more stable and tighter DC offset. And whats this oscillation problem your seeing? i'm assuming your talking about the phase between the two? rick Last edited by richard.C.; 30th July 2011 at 11:38 PM. |
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Two contiguous parcels offered together, separate or along with three other parcels across the street. The three parcels total 7. 37 acres and zoning is the same... see MLS 999566. Zoned for retail, office, medical or most institutional uses. Convenient to I-485 (1/4 mi), I-85, I-77, uptown Charlotte,and airport. Very near Mountain Island Lake. Great development opportunity...
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Forty-six transportation projects in 33 states and Puerto Rico are set to receive a total of $511 million from the third round of the U.S. Department of Transportation's (U.S. DOT) TIGER program.
The announcement comes months ahead of schedule and allows communities to move forward with critical, job-creating infrastructure projects including road and bridge improvements; transit upgrades; freight, port and rail expansions; and new options for bicyclists and pedestrians.
U.S. DOT received 848 project applications from all 50 states, Puerto Rico and Washington, D.C., requesting a total of $14.29 billion, far exceeding the $511 million made available for grants under the TIGER III program.
In November, President Obama directed the U.S. DOT to take common sense steps to expedite transportation projects by accelerating the process for review and approval and leveraging private sector funding to promote growth and job creation. As part of that initiative, DOT accelerated the TIGER III application review process and announced the awards before the end of 2011 - months ahead of the planned spring 2012 announcement.
The grants will fund a wide range of innovative transportation projects in urban and rural areas across the country:
Work has already begun on 33 planning projects while 58 capital projects are under way across the country from the previous two rounds of TIGER, and an additional 13 projects are expected to break ground over the next six months.
A complete list of grant recipients can be viewed here.
Up to six cameras will be installed on each bus. There is no live monitoring of the video which will only be removed and viewed by authorized security staff following a reported incident. Only video required for security purposes will be retained, all other video will be erased.
Pending adoption by its member entities, the merger between Victor Valley Transit Authority and Barstow Area Transit is slated to take effect July 1, 2015.
Officials at MCI's Pembina plant included Rep. Kevin Cramer, R-N.D.; North Dakota Commerce Department Commissioner Alan Anderson; Gail Hand, northeastern director for Sen Heidi Heitkamp, D-N.D.; Tom Brusegaard, regional director for Sen. John Hoeven, R-N.D; Pembina County Commissioner Hetty Walker; and Cavalier, N.D. Mayor Ken Briese.
Drivers are told to say 'namaste,' a common Indian greeting, and are encouraged to use their meters. Uber pays its drivers an additional 40 rupees, or just over 60 cents, per ride on top of the fare.
The unedited complaints represent only one side of the story and often are fired off by people who are upset. HART says its own GPS and video technology shows many are plain wrong. The agency relies upon the list to target areas of customer service that are in need of improvement.
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By Jazmine Hughes on Let's Talk About Birth Control
@LilyB RIGHT it's like "dude I'll remember to come back here in four days don't baby me (but literally don't BABY me this is the whole point of me taking you)"
By LilyB on Let's Talk About Birth Control
I don't take the placebo pills. I like the little calendar format of the pill pack, but I'm at a stage in my life where the placebos seem condescending, like I might literally forget I'm on the pill if I don't have to swallow one every single day. Not likely.
By Jaya on Let's Talk About Birth Control
I seem to have a body that is perfectly adapted to taking the pill, so I will likely never stop. Never gained weight, never had mood swings, and my period is two days long and features no cramps. I went off it for a couple months when I was traveling and NEVER AGAIN, oh god, my period was like a hurricane. Everyone has been trying to sell me on an IUD or something but hey, my body loves the pill! I'm not gonna fuck with that!
By sulpicius subuculus on On Hair, There and Everywhere, and Intra-Cultural Shame
@hedgehogerie I don't know why this has to be a competition. I'm a mostly-Scandinavian dark-haired mishmosh and yes, I do have a 5 o'clock pit shadow, and weeks when I shave my legs every 3 days - as the author apparently does - are weeks when I don't give a shit what my legs look like, because my leg shadow arrives around 3pm. Threading every 3 weeks? I plucked my eyebrows so much in high school and college that they were constantly bleeding/infected in an attempt to keep the unibrow at bay.
My point is that there's no need to do some kind of competitive-misery ethnic comparison. We all struggle with unrealistic body standards; yes, some of us have it rougher than others, but not necessarily on some kind of perfectly rank-able genetic scale; different people are different. Plenty of "blondies" have dark body hair; I had a redheaded friend who hated the way her (virtually invisible to me) leg hair SPARKLED in the sun. Commiserate, fine; but don't denigrate others for having their own bodily insecurities. I agree with "fuck whoever you are dating if they aren't down" (or don't fuck them, as the case may be). But let's also agree that people are allowed to worry about their bodies however they want.
By garysixpack on $3 Million for 7 Weeks
An old philosophy professor used to love to ask, "Are you God?" By that, he meant, "Are you omniscient? Are you infallible?" And if you are not, you should not be judged as if you were. You can only act to the best of your ability and to the best of your knowledge. And learn from the experience after you are done, of course. It's folly to think you can get more than that.
By demac on $3 Million for 7 Weeks
Thank you for telling this story. I can only imagine how painful this time must have been for you, and how painful it is for you still.
I have been on both sides of this situation. My grandmother, who helped raise me, died of inevitably-fatal glioblastoma, a brain cancer; when it was discovered, they predicted she had only months to live, though she died in weeks. The doctors told us that radiation might help her with keeping her mental state intact for a little longer, and she wanted to make it through to the new year a few months away, so she went through a course of radiation at a university hospital, which was excruciatingly painful - and scary for a woman who had never learned to read or speak English. We all decided shortly after starting the course that it wasn't worth it and stopped. She died weeks later, either on New Year's Eve or on New Year's Day - no one actually knows, because we discovered her death a few hours into the new year. We all like to think she made it into that next year, though.
It was an ugly death, as she had lost most of her bowel and bladder control, and had just defecated on herself on the way to the bathroom a few hours before. The burns on her head from the radiation were still visible at the funeral. I don't think I've ever been so angry and hurt at the same time.
And yet, a decade later, I am a doctor who has taken care of many terminal cancer patients. I can say that every one has stayed with me in one way or another, and I think that's true of all doctors; even if the names have left us, we still remember things like favorite desserts (which we buy for them personally from outside the hospital, because there's no brownie like Rosie's) or faces (eyes, smiles, dimples). And we remember family members, especially the ones who break our hearts with their crying, because all we want to do is cry too. (And sometimes we do.) But we have too many other patients to take care of, too many tests to order, too many labs to analyze.
I've cried and hugged family members, and I worry about adding my pain to theirs. But I do feel that it might be a good thing that they can see how much I care about this person that they love, that I'm not just a cog in the machine or a faceless representative of death.
I've taken care of many people who had little time left, and I have to say, at least from my experience, we try as hard as we can not to give false hope. (If for no other reason than hope has, in studies, shown no effect on survival rates or time to death - and because we wouldn't want doctors taking care of us to give us false hope.) We will tell people how unlikely treatments are to help them. I have told people that we couldn't help them multiple times, and each time is excruciatingly painful, because we all went into medicine to help people and having to tell them we can't and they will suffer because we can't is the worst thing to have to do.
The problem is that there are many, many times when we just don't know what will happen in the next few months or even the next few weeks - because, as far as modern medicine has gotten us, we're not God and all we have is 20/20 hindsight, not foresight. I promise you that, if we could, I would never - for a million dollars, for even another day with my own grandmother - put someone through the pain of chemotherapy if we could see beforehand that it wouldn't help, or that it would harm more than it helped at the end of life. And I think most doctors would agree.
There are some people who don't want to know if a treatment's likely to help or choose to try anyway, even if we ask in different ways, even if we disagree with their choices to pursue treatment. And, because at the end of life the most important thing we can give someone is their freedom to live what remains of their life as they choose, we will give someone chemotherapy if they want to try.
A lot of times, it is because, like my grandmother, they have some date they want to make it to. Or because they can't imagine going out without a fight. Or because they feel that they might be that one in a million that will beat the odds (though we try to explain the statistics as well as we can). We do our best to encourage hospice (preferably home hospice services, so people can be as comfortable as possible, at home with family and in familiar surroundings, when they pass). Almost all my colleagues agree that, with a terminal diagnosis, we wouldn't bother with treatment - we'd quit our jobs and go find a nice beach. And we tell our patients that when they ask us, and we will try to persuade people if we feel they're making a clear-cut bad decision. But unfortunately, a lot of times it's not that clear-cut.
It sounds like you're still angry with the doctor you spoke to on the phone, and towards the university hospital and hospital system he was at. I cannot speak to their missteps or mistakes, and I hate - HATE - that you had to deal with medical bills that are astronomical, and accompany a choice that only made the quality of your partner's end of life worse. And that you had to deal with them so soon, when he had just passed and your grief was raw and all-encompassing.
But I can say that hospitals are paid by insurance by the admission (at least in the state I live in), and the longer a patient stays or the more things that are done to that patient, the less overall money the hospital makes because the hospital will pay for the treatment regardless of the payment. The bill a patient's family gets at the end of an admission has little to do with what the hospital actually gets from the insurance company for services (and thus, little to do with what the services actually cost in terms of man-hours or wholesale cost of equipment). And doctors are not paid by the service while a patient is inpatient, and I don't know any doctor who would give an outpatient chemotherapy just to boost their income.
The other thing is that, though you didn't mention if your partner was in a clinical study or not at the end of his life, but (perhaps sadly, as they can help) most people are not and the hospital has no incentive to study him. Additionally, as a matter of ethics we would never keep people in the hospital or treat them against their prior wishes - that's why the drop-out rate in studies, especially for terminal cancer, tend to be relatively high. There is an ethics committee involved with every study, and that kind of behavior would be a very, VERY big issue.
When I've been that doctor at the end of a hospital stay, the doctor who's said, "Thank you for fighting with us," I've meant it the way that I think the doctor you wrote about meant it: thank you for helping us give it our best shot possible. We don't always agree that it should have been done, but we take our lead from what the patient wants.
And I've been that doctor who choked up on the phone, because if we could have known what would happen, we would have made different decisions and saved someone a lot of pain. But we make our decisions based on the best information we have available, and based on what a patient wants; we live with our own pain, too, that we cannot save everyone and that we may, in fact, cause harm in trying to help. It hurts every time that happens because all any doctor, from the time they were little to the time they take the Hippocratic Oath, has ever wanted to do is help. With my grandmother, even though I was a ball of rage when she died, I eventually realized that.
I am so, so sorry for your loss. I don't want to diminish your grief by addressing your anger towards these doctors, but I wanted to tell you how much doctors care and try to do their best for their patients.
By frenz.lo on Our Clif Bars, Ourselves
You can pry 'em out of my cold, dead, moderately nourished hands, snot rockets!
By kateek on Erica Gets An IV
Many years ago, I had blood drawn before surgery, so that I could have my own blood put back into me. They had trouble finding a vein, so they tied a tourniquet thingy on my arm first. When they put the needle in, the result was pretty much the same as Erica here.
By Faintly Macabre on Erica Gets An IV
@muddgirl When I worked at a medical practice, one of the Medical Assistants (who is also one of my Dream Second Moms) told me that at a previous job, the other MAs got jealous of her vein-finding abilities and hid difficult patients from her.
Luckily, I inherited my mom's super-easy veins, but I've still had some negligent lab techs hit a nerve or bruise me.
By Nancy Sin on Erica Gets An IV
The morphine dreams. THE WORST.


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A retired Hawaii Community Correctional Center guard has been sentenced to 25 years for wounding a Panaewa woman and committing an act of road rage.
The Hawaii Tribune-Herald reports 73-year-old Joseph Amormino of Hawaiian Beaches was sentenced Thursday in the injuring of 57-year-old June Shirshac on Mother's Day 2012 and road rage as he drove to see her.
He pleaded guilty Sept. 19 to felony assault, use of a firearm in a felony and terroristic threatening.
Prosecutors say Shirshac had broken off a relationship with Amormino. He changed his plea after Shirshac testified at his trial.
Shirshac was shot in her legs, right hand and shoulder. She testified that the recently widowed Amormino lavished gifts and a wedding ring on her though she didn't intend to marry him.
Copyright 2013 by The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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GD graphics lib. not working after install.
I installed GD graphics lib since i was going to generate some graphs using perl. I installed the GD module and used some sample code to test it out, but when i run in on my webserver i just get this instead of a picture (i have mod_perl installed in apache and its working fine with all other perl scripts): Code:
‰PNG ��� IHDR���d���d��z‹MQ���PLTE˙˙˙��˙˙�����Ž~ăą���tRNS�@ćŘf��IDATH‰ÍTKnÂ0Ń`'#°ň¸@Ľ–.r"ŹzŽ€Tşg$˜S,8BĐUoÎř{Üآ•:1/Ď~žycşŽkĄŠś^œqpAř°?ć^đ�pÂ-Řü ĐA"&ŘŔŒf4éWÓ˙—ôŮhăqÂłŽ4' _źëQoŽœ‰{âaĎ)Ó¸fš‡^ŻÓŃB:jRĽ˜h†ź ĺHąŐŻ5QňH%Ďěž×ŽnÓqşnŸ~_—G"ÚĄ˘Âˇé´)"î*"" 8Aă Code:
cpan[1]> install GD I have installed libpng/libpng-dev, libgd2-xdm/libgd2-xdm-dev as well as other needed libraries before installation, so i cant imagine what this can be. Everything ran fine when compiling and installing except the "make test" which isnt necessary, but i guess that the module wont work if the "make test" fails ? This was the output from the "make test" command: Code:
$ sudo make test This is a little wierd since the "make Makefile.PL" as well as the compilation ("make") and installation ("make install") is working without problems and the CPAN shell is also reporting that everything seems to be fine. Can someone please tell me why the GD module is not working here and why im getting the wierd letters instead of a picture? All help is appericiated. |
Debian - Ubuntu, related packages :
libgd2-xpm libgd2-xpm-dev libgd-tools libgd-gd2-perl But the missing one could be 'php5-gd' ? 'libgdchart-gd2-xpm' : A library for generating nice 2d and 3d graphs with the use of GD. ..... |
Hi -
One of the first things we need to figure out is whether this is: a) a problem with GD/your GD install ... or ... b) an Apache/Apache configuration issue SUGGESTIONS: 1. Try out "GD::Simple"", and see if it works (independent of trying to display anything from a web browser): http://perl.about.com/od/packagesmod...rlgdsimple.htm 2. Here's a more elaborate example: http://linuxgazette.net/issue81/padala.html It's not good that "make test" fails, but it's entirely possible that GD is working correctly anyway. Please try either of the above links to verify the basic install, and please post back what you find. Thanx in advance .. PSM |
It looks to me like you are generating a proper PNG image file, but transmitting it without the proper header. If the image is being transmitted as an inline image embedded in an HTML page, it might look correct. My guess is that you are calling the image directly by having your CGI transmit the PNG image as a full page. In this case, you will need to have the CGI prefix the proper header, at minimum:
print "Content-Type: image/png\n\n"; |
Thanks for the answers :)
As theNbomr suggested, "content-type: image/png\n\n" worked nicely, it produced an image instead of just text. |
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