text:
"Fairy Tales with a twist"
Not one of my favorites but it was still very good. To be fair, this is definitely a different audiobook than I usually go for.
She tried but her attempt to do the male voices came off...weird. The Woodcutter's voice was different at times...it had an Irish? accent one minute than it was gone. Sometimes it was scruffy then not. It was slightly distracting. It was more like I was being read to as opposed to immersing me in the story.
I loved how there was a twist to familiar Fairy Tales and how they crossed paths. I mean murder mystery among the happily ever afters?...what's not to like but there were several times that I was confused as to what was going on. I mean why was someone alive that I thought was dead? Without any spoilers, there were several loose ends that I don't feel got resolved. To be fair, I was listening at work and could have missed an important page or two but overall I felt that there was a few holes left to explain.
"Glad I took a chance"
Awesome take on an old classic. I saw that in a bookstore, it was in the YA section. I've read a few but it usually is the genre I avoid. I'm not a huge fan of teen angst, love, and poor decisions, but this really didn't have a whole lot of that. It was in my recommended list for a long time before I decided to give it a try. I'm glad I did...it was a fun listen. The author kept the story moving. I'd get home from work and sit in the car for 10 minutes because I don't want to stop listening. I didn't know it was a series so now I have to wait patiently for the next installment.
If this is your genre... you'll enjoy it... mystery, magic, and a hint of a maybe relationship. If it's not your usual kind of story...i'd say give it a chance. It may surprise you like it did me.
"A History/Sci-Fi mash up!"
Binny and Al. Loved them
I loved the premise of this book. I liked hearing about WWII history form this point of view. I was drawn it and couldn't stop listening to it. However, at times I was sooooo annoyed with the characters doom and gloom outlook and some of the decisions that were made. Don't get me wrong, I have not idea how I would react if I time travelled to WWII and got stuck but these 20 somethings acted as if they were young teens at times. And the lack of communication?!!? Come on guys! The three of them are stuck there together, why keep things from each other? It's not going to change the circumstances. I guess this is a testament to Connie Willis' writing: She made it very real to me like; I was right there wanting to shake some sense into them.
"F*** that, I want to live!"....then he tripped and was eaten
I haven't. He's partly the reason why I got the book...to hear how he did. He doesn't do character voices, he just reads the book. This is actually the first book I've listened to that the performer just reads as opposed to acts out the voices. Not sure I like it.
This was pretty funny. I looked like a lunatic at work randomly laughing at seemingly nothing at all (my headphones are hidden). Not going to change your life but an entertaining story. Like others mentioned the he said, she said, ______ said did get annoying. Maybe I noticed it more since it was pointed out in the reviews...which means you might notice it more since I just pointed it out.... you're welcome!
"Left me wanting"
I'm not sure. Maybe if they go on sale.
His voice is great for grisly detective/ PI characters. Reminds me of Dick Tracy.
The story itself left me wanting more. I bought the book during the try a new series sale. The first book didn't sound appealing to me so I went straight to the 2nd book. There didn't seem to be a lot of character depth (could have done it in the first book). It seemed like characters were presented, did their thing in the story and that was it.
The premise sounded interesting but it seemed rushed and anti-climactic. There wasn't really an explanation as to why the killer cop thought what he did that led to the murders. I mean the author alluded to it in a hazy sort of way but it seems that if the guy was a good detective like they said he was, then a little effort would have shown he was in error. And if his thoughts were just a reflection of his character, it would have been easier to see if there was more character development of the story. Also, I was pretty disappointed about not finding out what became of the Captain and his fiancée. Maybe that too is in another book but it made this book feel unfinished. It felt too "real life." In real life, you don't always get the answers as to why. But in a fictional book, I expect these questions to be answered
The book is not terrible. Like I said, the idea was great and I was eager to find out why it happened and how they would get there. But the dizzying speed of how it ended and the questions left over make me say, wait for it to be on sale.
"Definitely a dark horror"
Don't have the print version but R.C. Bray did bring it more to life with his voices than I could have reading it.
His voices brought the characters to life. He made it feel like I was a bystander watching the events rather than being read to. That's a huge plus for me in hearing an audiobook.
Not an extreme reaction but it did leave me feeling satisfied. I was a bit frustrated through some parts (based on some of the actions of the characters) but when it finally came to an end, I didn't feel lacking.
Great book! I came in thinking it would be like other post apocalyptic novels but this one had a twist. It reminded me of a TV show I used to watch...but I don't want to say what it is because it might give some of it away.
This is a very exciting book...something I will listen to again at some point.
""Realistic" zombie adventure"
The real feel of it. It almost felt like what would really happen if a zombie apocalypse occurred.
I really liked the book. Not a huge fan of the way it ended. Sets up nicely for a next book in the series but I felt that it was a bit rushed...not in pace with the entire book. I was kind of left frustrated but this only ensures that I'll buy the next book to see how it resolves. Hope he makes it soon!
"I totally geeked out!!!!!"
Zombies and robots in one seamless story?!?!?! Add a little science and BOOM...A nerds dream!
I did laugh at a few parts. Was frustrated at others but mostly just breathless at what was coming next.
I liked this book. Wasn't so much a scary/ suspenseful book zombie book nor a totally techy robot book but it was definitely a different look at both genres.
"Exciting and disturbing"
Nerve wracking and disturbing
Yes. I've listened to several of his performances. He makes all of these books come to life.
This book was good...good enough to get me to buy the 1st in the series. It was also disturbing...this could be because I'm a new mother. I'm not bothered by gore (which this book has) but shows zombies in a way I've never seen. Definitely worth the read though. Lots of adventure and suspense. And I can't say enough about R.C. Bray.
"Yes We did...we did enjoy this!!!"
One word...Legion!
Everything!! He is awesome! My favorite since becoming a member of Audible. In fact, I just used his name to search for new books. He makes the characters. He makes it so you feel like you are in the book and not being read to. Sometimes I forget that there is one man talking, not multiple characters.
There are some parts that are very frustrating but overall the story was very intriguing. Time travel to the time of Jesus. I had to download. I like how they protrayed the relationships between the 12 and Jesus. I also loved how it all came together. It is a very interesting read.


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21 - 40 of 57 Comments
Last updated Jul 21, 2014
Apo, AE |
Oct 24, 2012
Some of the things that Jeremy Easter saw in Vietnam and the thing that he had to do to survive make finding him a tough job. Perhaps Jeremy does not want to be found. Consider that, McK, before you start to judge.
My heartfelt condolences to the Easter family. |
Saudi Arabia |
Oct 26, 2012
Please tell me Jermey has been found.
Apo, AE |
Oct 26, 2012
Hey, McK, might be time to file a missing persons report on Jarman Eastman. That's right put down your crack pipes and Access cards and give the o;e popo a call.
United States |
Dec 7, 2012
Still out there? Every Rose has its Thorne. |
Apo, AE |
Dec 9, 2012
Hey, McK, perhaps McKLightning knows Mr. Easter's whereabouts. I read a little ditty about him and his Easter escapades as the ether bunny. Jeremy Easter missing, McKLightning doing ether bunny shennanigans on Easter....coincidence, I think not.
United States |
Dec 9, 2012
Rosaylia is looking for Ursidae. The last time i saw you was in Memphis. If this rings a bell, let me know. |
Apo, AE |
Jan 18, 2013
Anyone give me a status update on locating Jamin Easter?
Apo, AE |
Jan 28, 2013
If you McK people had any heart, then you would have already found Jairmy. Seems most of you would prefer to focus on Collins Street, the Machine, or body searching hobos.
Jairmy had a name, people, and it was Easter. Ponder on that the next time your hangin' out eith the Roohoohoo brothers on Collins Street. |
Feb 25, 2013
When we saw the hypnotist.
United States |
Feb 25, 2013
It saddens me that we have no status on Jarmin. My heartfelt sympathies to the Easter family. Vietnam was a tough period for all of us.
Feb 25, 2013
You were passing through with her, on your way to one of her shows. I took a very long lunch hour to see you for a few hours.
Every December 30th, I've worried about you -- if you were making it okay. Not wanting to make trouble for you. Just wanted to say I miss you and wish things had worked out differently. You are "the one who got away". |
United States |
Feb 28, 2013
I told everyone that no good would come from ole Jarmin Easter. It's no wonder the psycho came back from the Nam all jacked the fudge up. Keep the expectations low, McK...my advice to all the lil criminals growing up in the Port today.
Mar 6, 2013
I remember get my partay on with good ole Jeremy many moons ago. Walking point in the bush in the "Nam" changed all that for Jeremy. Dampened his spirit and destroy his natural talent for getting his partay on.
Mar 6, 2013
Say what you want about Jarmin, all he wanted was something to eat at the Hyehold, but the man kept pushing. They drew first blood not him, they drew first blood...
I heard he went back to Nam and rescued a bunch of POW's from a supposedly deserted POW camp. And lost his girlfriend in the process. He was awarded another Congressional Medal of Honor, and gave it to the men he rescued. All he wanted was for his country to love him, as much as he loved it. That's the Jarmin I remember... |
Mar 13, 2013
It would be good to hear your voice Jarmin, it's been a long time. Look Jarms, you've done some damage here in the Port, they don't want anymore trouble. That's why I've come. I want to come in there and fly you the hell out. Just you and me. We'll work this thing out together. Is that fair enough?
Mar 13, 2013
As I remember, I didn't get away. I was let go.
Mar 18, 2013
How did you find me?
Mar 18, 2013
Back in the day...we were in this bar in Saigon and this kid comes up, this kid carrying a shoe-shine box. And he says "Shine, please, shine!" I said no. He kept askin', yeah, and Jeremy said "Yeah." And I went to get a couple of beers, and the box was wired, and he opened up the box, fudging blew his body all over the place. And he's laying there, he's fudging screaming. There's pieces of him all over me, just...like this, and I'm tryin' to pull him off, you know, my friend Jeremy that's all over me! I've got blood and everything and I'm tryin' to hold him together! I'm puttin'... the guy's fudgin' insides keep coming out! And nobody would help! Nobody would help! He's saying, sayin' "I wanna go home and see Rosaylia! I wanna go home!" He keeps calling my name! "I wanna go home, Johnny! I wanna drive my Chevy!" I said "With what? I can't find your fudgin' legs! I can't find your legs!"
Everything after that was cool once we got a grasp of the leg situation. |
Mar 18, 2013
Rosaylia, the next time I am in contact with Jeremy I will pass him the word that you are concerned and wish to establish contact with him. Unfortunatly this may not ever become possible for I have not seen Jeremy since 1996 in L.A when he shot and killed Tupac Shakur. Remain strong Rosaylia, remain stong..- |
Cancún, Mexico |
Mar 19, 2013
Wasn't difficult. Glad you've found happiness in your career and family life. You deserve it. I live in two countries now, back and forth between the U.S. and another. Right now, I'm sitting in an airport in another country, waiting on a flight. It's a crazy life. |
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subset: commoncrawl


text:
McCormick, John S., MD
Bensley Pavilion, 1st floor
1 Diamond Hill Road
Berkeley Heights, NJ
Biochemistry and Molecular Biology, University of California, Santa Cruz, CA, School of General Studies, Columbia University, New York City
MD:Albert Einstein College of Medicine, Bronx, NY
Internship:Overlook Medical Center, Summit, NJ
Residency:Diagnostic Radiology, Overlook Medical Center, Summit, NJ
Fellowship:Nuclear Medicine, Overlook Medical Center, Summit, NJ
Board Certification:Special Competency in Nuclear Radiology, American Board of Radiology
Hospital Affiliations:Overlook Medical Center
McCormick, John S., MD
I am accepting new patients.
Personal Notes:
In addition to his position at Summit Medical Group, John S. McCormick, MD, is an attending radiologist at Overlook Medical Center in Summit, New Jersey. His expertise includes chest imaging, abdominal imaging, pelvic imaging, and musculoskeletal nuclear medicine.
Before joining Summit Medical Group, Dr. McCormick was Primary Radiologist for Cranford Diagnostic Imaging in Cranford, New Jersey. He also has been Radiologist and Director of Nuclear Medicine at Brookhaven Memorial Hospital in Patchogue, New York.
Dr. McCormick is a diplomate of the American Board of Radiology and a member of the American College of Radiology, Society of Nuclear Medicine, and Radiological Society of North America.


text:
Differences between current version and predecessor to the previous major change of MDF.
Other diffs: Previous Revision, Previous Author, or view the Annotated Edit History
Newer page: | version 4 | Last edited on Sunday, July 3, 2005 6:04:25 pm | by AristotlePagaltzis | |
Older page: | version 2 | Last edited on Wednesday, June 9, 2004 3:38:37 pm | by DavidHallett | Revert |
@@ -1 +1,3 @@
An [Acronym] for MainDistributionFrame or __M__edium __D__ensity __F__ibreboard. The latter is a wood based composite panel. It is made using fine wood fibres bonded under heat and pressure with an adhesive. Great for making inexpensive computer furniture!
+Ironically, a piece of (or pieces of depending on size) medium density fibreboard is typically used as the backing board for a MainDistributionFrame.


text:
The importance of movement for people living with chronic obstructive pulmonary disease
Williams, Veronika, Bruton, Anne, Ellis-Hill, Caroline and McPherson, Kathryn (2011) The importance of movement for people living with chronic obstructive pulmonary disease. Qualitative Health Research, 21, (9), 1239-1248. (doi:10.1177/1049732311405801). (PMID:21511979).
Full text not available from this repository.
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that gives rise to symptoms of breathlessness, chronic fatigue, and cough. The impact of COPD on people's activity has been widely acknowledged, yet it appears that we know little about how individuals experience activity. We employed a grounded theory study with 18 participants with COPD to explore their dimensions of activity. We identified two core concepts that captured participants' experience of activity; these were stagnation and movement. We found fresh air to be the single most important aspect affecting participants' experience of stagnation and movement; this was linked to a changed perception of symptoms. We identified the environment as an important context influencing the experience of COPD and activity. Our stagnation–movement theory explains the experience of activity within its environmental context, and how this experience might be affected on physical, social, and psychological levels.
Item Type: | Article |
ISSNs: | 1049-7323 (print) |
Related URLs: | |
Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RB Pathology |
Divisions: | University Structure - Pre August 2011 > School of Health Sciences |
ePrint ID: | 182859 |
Date Deposited: | 28 Apr 2011 11:32 |
Last Modified: | 27 Mar 2014 19:38 |
URI: | http://eprints.soton.ac.uk/id/eprint/182859 |
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Latest Headlines
What are online audiences watching this year? How are they engaging with their content across platforms? In this quarterly update we'll present some raw stats released by online audience measurement firms including comScore, Rentrak and Nielsen.
Apple maintained its dominance in the U.S. smartphone market over the summer, according to the latest figures from research firm comScore. Given the boffo opening sales weekend Apple had for its new iPhone 6 and 6 Plus, that lead is likely to swell through the fall.
"May turned out to be a banner month for mobile," research firm comScore noted, pointing to its new research showing that mobile platforms--smartphones and tablets--combined to account for 60 percent of "total digital media time spent," up from 50 percent a year ago. The firm also said that mobile apps accounted for more than half of all digital media time spent in May at 51 percent.
It's not always easy to condense an event into a few words, but in the case of tthis year's TM Forum Live, key buzzwords immediately spring to mind: NFV--the much-discussed Network Functions Virtualisation--big data analytics and the digital enterprise.
The number of online video viewers keeps growing steadily, and those who have completely cut the cord from pay TV are happy with their decision, a pair of newly released reports from comScore and nScreen Media reveal. But pay-TV providers are battling the trend.
A financial analyst is pouring water on recent studies that say online video advertising will overtake TV ads within the next few years. Television still has much greater reach than online video, with 115.6 million TV homes in the United States, and isn't likely to end its reign anytime soon.
Google's Android regained some U.S. market share as of the end of October after losing share last spring, according to a new report from digital research firm comScore. The firm also reported that Apple is the No.1 smartphone maker in the U.S. with 40.6 percent share.
According to a detailed report from New Street Research analyst Jonathan Chaplin on wireless carriers in the first quarter, fewer people are buying smartphones. This means that wireless carriers as a group will no longer benefit from millions of people upgrading from a feature phone to a smartphone--those who want smartphones already have them, and those who don't most likely won't buy one anytime soon.
Nearly 60 per cent of mobile users in France, Germany, Italy, Spain and the UK (the EU5) owned a smartphone in the three-month average ending December 2012, according to a comScore's report.
Consumers moving to online video to avoid watching ads are finding less relief and more pitches as the number of ads in digital content grew by about two-thirds between December 2011 and December 2012.
Press Releases
- AT&T Invests More Than $350 Million Over Three-Year Period To Enhance Local Network In Orlando Area
- Ofcom and Sky to Speak at Connected Britain
- Comcast Announces 2 Gigabit Residential Service And New Extreme 250 Mbps Tier In California
- Bell's Fibe TV and FibreOP TV now serve 1 million Canadians
- CenturyLink appeals net neutrality decision
- More Press Releases
Sponsored Links


text:
A stylish way to tote your keys, this vintage key chain features a painted silver ball that has a fair amount of weight to it (not sure of the material that it's made of) that is dotted with glue set clear rhinestones. The ball measures 1 1/8" in diameter and the total length is 3 3/8" and it is in excellent previously owned condition.
Vintage collectibles, jewelry and accessories - the stuff that retro dreams are made of!
New items arriving weekly!
Shipping/Handling: | $3.00 USD |
Insurance: | Included |
Price for shipping to USA change location


text:
Got a tip for us? Let us know
Nov 4, 2004, 09:36 AM | #1 |
Review and photos of Lemke's GraphicConverter 5.3
Category: Reviews Link: Review and photos of Lemke\'s GraphicConverter 5.3 Posted on MacBytes.com Approved by Mudbug |
0 |
Nov 4, 2004, 09:48 AM | #2 | |
Its works well these days as an alternative to iPhoto; its browser doesn't grab control of the directory structure away from you. Way faster too, and the original functions (batch conversion) still don't really appear in as usable a form anywhere else. |
0 |
Nov 4, 2004, 11:26 AM | #3 |
You gotta love the title of this one...
...it's sooooooo misleading!
It's hard to argue with the premise. If ever there was an inexpensive graphic utility that did what it said it would do I don't know what it would/could be other than Graphic Converter. Some like GIMP but it's waaaaay too much X-windows for me. And complicated. The developer, Thorsten Lemke, is somewhat like the guy who does VueScan, the "this will work on any scanner" application. Worth the money. What was the real title of this article again? |
0 |
Nov 4, 2004, 02:55 PM | #4 |
But the Macbytes title *is* misleading! I was specifically promised a "Review and photos of Lemke's GraphicConverter 5.3, and the only photo is of some guy with flowers growing out of his skull, deciding which pair of socks will go best with them. That's simply wrong.
0 |
Nov 4, 2004, 03:05 PM | #5 |
All I really learned from this article is that GraphicConverter costs "10-cents a day (for a year)". Just tell me the d*mn software costs $30 for goodness sakes.
And yea, where were the review and pictures. Nowhere to be found. Fine if you know absolutely nothing about GraphicConverter, but I used to use it and was hoping to see what was new and improved w/ the software. Oh well.
"These days, new digital music download services are becoming more common than spare AOL CDs." |
0 |
Nov 4, 2004, 03:16 PM | #6 |
Oh, actual new 5.3 features? The usual bug fixes and incremental improvements/additions, but the most noticeable changes this time are a caliper tool (measures the distance in pixels between any two points, any angle -- useful for scaling compositions) and a "slice" tool that can be useful for doing bletcherous things in WWW pages. All the gory change details going waaaay back are here.
It's still not trying to be a Photoshop or Painter. You get simple pencil, eraser and bucket tools, but not much else in the way of brushes. |
0 |
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text:
Mercer County man shot, wife charged
Updated: 01/06/2015 - A man is in the hospital and his wife is in jail after a shooting.
Updated: 01/06/2015 - A man is in the hospital and his wife is in jail after a shooting.
Posted: 01/06/2015 - Rest areas along Interstate 71 in Oldham County are closing Tuesday for about a month while repairs are made.
Posted: 01/06/2015 - A south-central Kentucky man has pleaded guilty to charges in connection with the death of his wife last June.
Updated: 01/06/2015 - Democratic candidate for governor Jack Conway will announce money for a project to reduce the number of heroin overdose deaths.
Posted: 01/06/2015 - Colorado will share $22 million with California, Florida, Kentucky and Ohio.
Updated: 01/06/2015 - The Wayne County coroner tells WKYT that two people were killed in a crash on Monday.
Updated: 01/06/2015 - UK HealthCare officials say this flu season is bad and only getting worse.
Posted: 01/05/2015 - Some tense moments at the Blue Grass Airport, as emergency crews thought a plane was in trouble on Monday evening.
Updated: 01/05/2015 - The farther north you are, the better chance you'll have of seeing snow and state road crews say they've been pre-treating roads in northern counties.
Updated: 01/06/2015 - Firefighters in Rockcastle County are investigating a fire that destroyed much of a home on Monday.
Updated: 01/05/2015 - The National Guard soldier hit by a SUV outside a Lexington bar in 2014 is saying good-bye and thanks to the Lexington community.
Updated: 01/05/2015 - State police are still investigating what led to a wild police chase that ended outside the Kentucky State Capitol.
Updated: 01/05/2015 - The patrol cars and SUVs have an in-car computer with Wi-Fi, allowing officers to pull mug shots and criminal backgrounds in seconds. "So any access I have from my desk in my office, the office on the street has the exact same access as I do," Lt. Mike Wright said.
Updated: 01/06/2015 - Republican James Comer says he has raised more than $1 million for his campaign for governor.
Updated: 01/05/2015 - Burgin Police say a burglary investigation led to a high-speed chase through Mercer County.
Updated: 01/06/2015 - The nation's coal mines set a record for the lowest number of on-the-job fatalities last year, with 16.
Posted: 01/05/2015 - Kentucky Republicans could clean house on Tuesday as they select leaders for the upcoming legislative session following a disappointing showing in the November elections.
Updated: 01/05/2015 - The coldest air of the season comes our way this week.
Updated: 01/05/2015 - It's back to work for students and Fayette County Public Schools' acting superintendent.
Updated: 01/05/2015 - Aaron Stailey,18, is the third person charged in a December shooting that killed a young woman and injured three others.
Updated: 01/05/2015 - Relatives told WKYT that the homeowner, Danny Bailey, was found dead inside.
Updated: 01/05/2015 - Over a dozen people are behind bars after state police say they discovered a cockfight at a Clinton County barn.
Updated: 01/05/2015 - The Laurel County Sheriff's Office charged 66-year-old Sherman Jones with animal cruelty.
Updated: 01/04/2015 - A car flipped onto its side Sunday night on Dolan Lane, about half a mile off of Leestown Road.
Updated: 01/04/2015 - Thousands of students across Kentucky will head back to school on Monday, and this year, the end of the holiday break lines up with a rise in flu cases.


text:
Linked by Thom Holwerda on Mon 23rd Sep 2013 22:52 UTC
Apple today announced it has sold a record-breaking nine million new iPhone 5s and iPhone 5c models, just three days after the launch of the new iPhones on September 20. In addition, more than 200 million iOS devices are now running the completely redesigned iOS 7, making it the fastest software upgrade in history.
Permalink for comment 573197
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To read all comments associated with this story, please click here.
This is inaccurate. If you want an update that is tied to the latest version of iOS you obviously have to update. However Apple just changed the way the store works so it will now let you choose the last compatible version so now you still have access to a 100k worth of apps even if you don't upgrade.


text:
Latest Domain name system Stories
NEW YORK, November 6, 2014 /PRNewswire/ -- Over the past few years, the .EU Registry has grown exponentially and is now among the top 12 TLDs in the world, with over 3.5
DNS Made Easy shows companies of all sizes how to build a safe, secure network that stays online. RESTON, VA (PRWEB) November 05, 2014
Carrier-grade IP Address Management Software Offers Comprehensive and Centralized View of IP Resources to Streamline the IP Request and Assignment Process Vancouver,
NameJet in partnership with co.com Registry are bringing 50 worldwide major city domain names to the domain name aftermarket. Kirkland, WA (PRWEB) November 04,
Steer clear of DDoS attacks with safety features DNS Made Easy has in place Reston, Va.
Namecheap is now offering hosting packages at prices that start under $10 per year with a 100% uptime SLA and cPanel. (PRWEB) October 30, 2014 Namecheap,
DNS Made Easy prepares companies for the holidays with 13 years of up time, the highest uptime percentage in the industry. RESTON, VA (PRWEB) October 24, 2014
Latest Domain name system Reference Libraries
Image Credit: Photos.com The top-level domain (TLD) refers to the highest level in the Domain Name System of the internet. It is the last part of the domain name. For example, in www.example.com, .com is the TLD. Domain names are not case sensitive so .COM works the same as .com. The management of most TLDs are assigned by the Internet Corporation for Assigned Names and Numbers (ICANN), which operates the Internet Assigned Numbers Authority (IANA) and maintains the DNS root zone. The...
- A person or thing gazed at with wonder or curiosity, especially of a scornful kind.


text:
Author Affiliations: Departments of Oral Diagnostic Sciences (Dr Tezal), Oral Biology (Dr Tezal), Restorative Dentistry (Dr Sullivan Nasca), Social and Preventive Medicine (Drs Tezal and Hyland), Microbiology and Immunology (Dr Melendy), and Surgery (Dr Loree), State University of New York at Buffalo; and Departments of Dentistry and Maxillofacial Prosthetics (Drs Tezal and Sullivan Nasca), Head and Neck Surgery (Drs Stoler, Rigual, and Loree), Cancer Pathology and Prevention (Dr Stoler and Mr Smaldino), and Cancer Prevention and Population Sciences (Dr Hyland), Roswell Park Cancer Institute, Buffalo, New York.
Objective To assess whether chronic periodontitis history predicts human papillomavirus (HPV) status in patients with base of tongue cancers.
Design Case-control study using existing patient data.
Setting Roswell Park Cancer Institute.
Patients Thirty patients newly diagnosed with base of tongue squamous cell carcinoma between 1999 and 2005 for whom both tumor samples and periodontal records were available. Patients younger than 21 years, edentulous, immunocompromised, and those with a history of cancer were excluded. Periodontitis history was assessed on the basis of alveolar bone loss (in millimeters) from panoramic radiographs by one examiner who was blinded to cancer status.
Main Outcome Measure HPV-16 and HPV-18 DNA were identified on paraffin-embedded tumor samples by polymerase chain reaction. Multiple logistic regression was used to estimate odds ratios and 95% confidence intervals.
Results The prevalence of tumors positive for HPV-16 DNA was 21 of 30 (70%). None of the samples were positive for HPV-18 DNA. Compared with participants with HPV-negative tumors, patients with HPV-positive tumors had significantly higher mean alveolar bone loss (3.90 mm vs 2.85 mm, P = .01). After adjustment for age at diagnosis, sex, race/ethnicity, alcohol use, smoking status, and number of missing teeth, every millimeter of alveolar bone loss was associated with an approximately 4-fold (odds ratio, 3.96; 95% confidence interval, 1.18-13.36) increased risk of HPV-positive tumor status. Number of missing teeth was not associated with tumor HPV status (odds ratio, 0.95; 95% confidence interval, 0.74-1.21).
Conclusions Chronic periodontitis may be a significant factor in the natural history of HPV infection in patients with base of tongue cancers. Additional confirmation in larger studies is required.
It is now recognized that human papillomavirus (HPV) may be an additional independent risk factor for a subset of head and neck cancers (HNCs).1,2However, most HPV infections are cleared rapidly and do not cause malignancy. Persistence of HPV infection is a central risk factor for carcinogenesis.2 Therefore, understanding the factors for the persistence of oral HPV is critical to facilitate effective prevention of HNCs. Coinfections in the cervix with particular bacteria such as Chlamydia trachomatis and chronic cervicitis were shown to act synergistically with HPV to increase cervical cancer risk.3 In addition, increased levels of inflammatory cytokines, such as interleukins 1 and 6 and tumor necrosis factor α, were shown to modulate HPV gene expression and proliferation.4,5 In a recent study, a nonsteroidal anti-inflammatory drug induced specific degradation of the HPV oncoprotein E7 and caused growth arrest and apoptosis in cervical carcinoma cells.6
Periodontitis is a chronic oral infection caused by inflammatory reactions to gram-negative anaerobic bacteria in the dental plaque.7 It leads to irreversible destruction of tissues around teeth, clinically detectable as periodontal pockets and alveolar bone loss (ABL). Periodontitis results in a continuous release of bacterial toxins and inflammatory markers into saliva and, to a lesser degree, into the bloodstream.8Human papillomavirus infects exclusively the basal cells of the epithelium. It gains access through abrasions or through normal exposure of parabasal cells, such as in the transformation zone of the uterine cervix. In addition, replication of virus is closely associated with proliferation of the basal and parabasal cells.9 The periodontal pocket is composed of stratified squamous epithelium and is characterized by continuous epithelial proliferation, migration, rete-ridge formation, and ulcerations, providing ample opportunity for initial HPV infection and its persistence. Integrin α6β4 and syndecan-1, candidate receptors for HPV, are expressed during wound healing and are present in the periodontal pocket epithelium.10
It was also suggested that periodontal pockets may serve as a reservoir for latent HPV.10,11 Latent state would require the presence of infected cells that fail to differentiate.9 The junctional epithelium at the bottom of the periodontal pocket appears to fully serve the cellular functions required by HPV. The junctional epithelium is composed of basal and suprabasal cell layers only and has a very high turnover rate. The basal cells are exfoliated through the gingival crevice before differentiation occurs.10 Frequent occurrence of gingival papillomas and condylomas in human immunodeficiency virus (HIV)−positive participants and in patients with organ transplants receiving cyclosporine treatment could be explained by reactivation of latent HPV.12
In a recent study funded by the National Institutes of Health, we found an independent association between chronic periodontitis and the risk of tongue cancer.13 Based on these observations, we conducted the present study to test the hypothesis that chronic periodontitis is a predictor of the tumor HPV status in patients with base of tongue squamous cell carcinoma.
We performed a hospital-based case-control study. The study population was derived from the patient population of the Department of Dentistry and Maxillofacial Prosthetics (DMFP), Roswell Park Cancer Institute. All patients newly diagnosed with primary base of tongue squamous cell carcinoma (International Classification of Diseases for Oncology, 3rd edition, code C01.0)14 between June 15, 1999, and January 10, 2005, who had tissue samples available through Pathology Department archives were included. Patients younger than 21 years, edentulous, immunocompromised, and those with a history of cancer were excluded. All patients with HNC who receive radiotherapy and/or chemotherapy are admitted to the DMFP before the initiation of their cancer treatment. From a total of 47 newly diagnosed patients with base of tongue cancer who were diagnosed during the study period, 33 were admitted to the DMFP. Of those 33 patients, 3 were edentulous. Therefore, 30 patients had both periodontal and pathology data available (26 men and 4 women). The study protocol was approved by the institutional review boards of the Roswell Park Cancer Institute and the State University of New York at Buffalo.
History of periodontitis was assessed quantitatively on the basis of ABL from panoramic radiographs that were taken at admission before the cancer treatment was initiated. Radiographs were taken with a software-controlled orthopantomograph (model OP100; Instrumentarium Imaging, Tuusula, Finland) using standard exposure time (17.6 seconds) and settings (70 kVp and 12 mA). Patient positioning was also standardized with the help of head, temple, and chin supports; bite fork; occlusion adjustment keys; and positioning lights.
Alveolar bone loss is an established measure of periodontitis history.15 It is an outcome measure and quantifies cumulative vertical bone loss as a result of inflammation. The distance between the cementoenamel junction and the bone crest in a line parallel to the long axis of the tooth is measured in millimeters. Measurements were performed on mesial and distal surfaces of all natural teeth using an operator-interactive program on digitized radiographic images by a trained periodontist. Typically, ABL less than 2 mm is considered to represent normal or healthy periodontium. Accuracy and reliability of this method have been previously established.15 In the present study, all ABL measurements were performed by one examiner who was blinded to HPV status. Duplicate ABL measurements were performed on 5 randomly selected study participants with a 3-day interval to establish intraexaminer reliability. The mean (SD) differences of the duplicate measurements was 0.22 (0.41) mm.
The presence or absence of HPV DNA in tumor tissue was determined by polymerase chain reaction (PCR). All specimens were reviewed by a pathologist to confirm the presence of tumor on slides. DNA extraction and PCR amplification are performed in separate laboratories to reduce contamination.
Three 10-μm sections were cut from paraffin-embedded tumor sections as identified in the Pathology Department to ensure adequate isolated DNA from tumor tissue. DNA was extracted from tumor samples using previously described procedures.16 Microtome blades were changed between each embedded block to prevent cross-contamination among specimens. Paraffin was removed through xylene treatment, and the specimen was rehydrated in a decreasing ethanol gradient. An overnight digestion at 60°C in a cocktail containing 50mM potassium chloride, 1.5mM magnesium chloride, 10mM TRIS hydrochloride, 0.5% polyethylene glycol sorbitan monolaurate [TWEEN 20; Sigma-Aldrich Corp, St Louis, Missouri], and 200 μg/mL proteinase K was followed by RNase A (100 μg/mL) digestion, phenol/chloroform extraction, and ethanol precipitation. This procedure produces high-molecular-weight DNA suitable for PCR analyses.
Purified DNA (100 ng) served as a template in each of 3 separate 25-μL reactions. Reactions 1 and 2 contained 0.25mM forward and reverse type-specific primers for the E6 regions of HPV-16 and HPV-18, 1.5mM magnesium chloride, 2.0mM deoxynucleotide triphosphates, and 1 U of Taq DNA Polymerase (Invitrogen, Carlsbad, California) in a 1× amplification buffer. The forward and reverse primers for these reactions were HPV-16 forward 5′-ATTAGTGAGTATAGACATTA-3′; HPV-16 reverse 5′-GGCTTTTGACAGTTAATACA-3′; HPV-18 forward 5′-ATTAGAGAATTAAGACATTA-3′; and HPV-18 reverse 5′-GGTTTCTGGCACCGCAGGCA-3′. Reaction 3, a control that amplifies a DNA fragment from the housekeeping gene β-globin, differs from reactions 1 and 2 only in the primers added and in that it contains 2.5mM magnesium chloride. The forward and reverse primers for this reaction were β-globin forward 5′-CAACTTCATCCACGTTACCC-3′ and β-globin reverse 5′-GAAGAGCCAAGGACAGGTAC-3′. All PCRs were assembled in a laminar flow sterile cabinet dedicated to that purpose. Triplicate amplifications were performed in a thermocycler (model PTC 100; MJ Research, Inc, Waltham, Massachusetts) as follows: initial denaturation at 95°C for 7 minutes followed by 40 cycles at 95°C for 45 seconds (denaturation), 52°C for 1 minute (annealing), 72°C for 1 minute (extension), and a 5-minute final extension at 72°C. Plasmids containing the E6 region of HPV-16 or HPV-18 were used as positive controls for PCR amplification. A mock reaction containing no DNA was used as a negative control.
Of each PCR, 5 μL was resolved by electrophoresis on a 3% LE (low electroendosmosis) agarose gel containing 1 μg/mL ethidium bromide. The presence of a 109–base pair fragment in either of the first 2 reactions confirmed the presence of one of the HPV isotypes in the sample, while a 268–base pair β-globin fragment in reaction 3 established the ability of the DNA to be amplified in the absence of either HPV band. Samples that were negative for β-globin were considered to be of insufficient quality for analysis and were excluded. Amplified DNA was visualized by ultraviolet transillumination. Tumor-derived samples of 10 to 100 ng of genomic DNA containing approximately 100 molecules of viral DNA routinely score positive in PCR assays. Primer design allows for viral type-specific amplification. Tumors that are positive for amplification of the HPV-16 E6 region do not amplify with primers for the highly homologous region of HPV-18.
Means, standard deviations, frequencies, and proportions of available relevant variables were used to describe the study population. Selection and definition of covariates were limited with the information available in existing patient records. Information on age at diagnosis (years); sex; race (white, African American, Asian, Native American/Alaskan, Hawaiian/Pacific Islander, other); ethnicity (Hispanic, non-Hispanic); alcohol use (never, ever) and cigarette, pipe, or cigar smoking status (never, former, current); tumor stage (I-IV); and tumor differentiation (poor, moderate, well) was available electronically from the Roswell Park Cancer Institute Hospital Information System. Information on missing teeth was obtained from radiographs.
To compare HPV-positive cases and HPV-negative controls for similarity, the Mann-Whitney test for continuous variables and Fisher exact test for categorical variables were used. We have performed receiver operating characteristic curve analysis to identify a cut point for ABL for the definition of periodontitis. The independent effect of periodontitis on tumor HPV status was estimated from multiple logistic regression analysis after adjusting the effects of age at diagnosis, sex, race/ethnicity, smoking status, alcohol use, and number of missing teeth. Odds ratios and their 95% confidence intervals were calculated. A 2-sided α < .05 was set to indicate statistical significance. SPSS software, version 15.0 (SPSS Inc, Chicago, Illinois) was used for data analyses.
Thirty new cases of primary base of tongue squamous cell carcinoma were diagnosed between June 15, 1999, and January 10, 2005, for whom we had both periodontal and pathology data available. The prevalence of tumors positive for HPV-16 DNA was 21 of 30 (70%). None of the tumor samples were positive for HPV-18 DNA. According to the receiver operating characteristic curve analysis, periodontitis was defined as ABL of 2.74 mm or greater. Compared with participants with HPV-negative tumors, those with HPV-positive tumors had significantly higher mean ABL (3.90 mm vs 2.85 mm, P = .01) and a greater prevalence of periodontitis (86% vs 22%, P = .002). Remaining variables—age, sex, race/ethnicity, smoking, alcohol use, tumor stage, and tumor differentiation—were not significantly different between cases and controls (Table 1).
Stratification of the periodontitis-HPV association by smoking status revealed that the history of periodontitis was associated with HPV-positive tumor status in smokers and nonsmokers. On the other hand, the effect of smoking on tumor HPV status depended on periodontitis history. All (6 of 6) of the never-smokers had HPV-positive tumors and 83% (5 of 6) of them had a history of periodontitis. Among smokers, 87% (13 of 15) of those with HPV-positive tumors had a history of periodontitis, and 78% (7 of 9) of those with HPV-negative tumors had no history of periodontitis (Table 2). Stratification of the periodontitis-HPV association by alcohol use yielded similar results: Among patients with HPV-positive tumors, 77% (10 of 13) of the nondrinkers and all of the drinkers (8 of 8) had periodontitis. Among patients with HPV-negative tumors, 75% (3 of 4) of the nondrinkers and 80% (4 of 5) of the drinkers had no history of periodontitis (Table 3).
Every millimeter of ABL was associated with an approximately 3-fold (odds ratio, 2.86; 95% confidence interval, 1.03-7.98) increased risk of HPV-positive tumor status. Number of missing teeth was not significantly associated with tumor HPV status (0.94; 0.86-1.12). After adjustment for age at diagnosis, sex, race/ethnicity, alcohol use, smoking status, and number of missing teeth, each millimeter of ABL was associated with an approximately 4-fold (3.96; 1.18-13.36) increased risk of HPV-positive tumor status (Table 4). The model explained 76% of the variation in tumor HPV status.
Chronic periodontitis may play a significant role in the natural history of HPV infection in patients with base of tongue cancer. Despite a small sample size, the association was statistically significant. These results encourage larger epidemiologic studies to confirm this association and basic science studies to test the roles of chronic inflammation and bacterial coinfections in the natural history of oral HPV infection.
Infection of hosts by multiple microorganisms is the norm rather than the exception, yet much research has focused on single pathogens. Studies suggest that viruses and bacteria, mostly studied in isolation, may in fact cooperate synergistically and should be considered as a pathogenic consortium.3,10,11,17 The prevalence and severity of both periodontitis and HPV infection are significantly higher in patients infected with HIV and herpesviruses.18,19 This provides additional indirect evidence for periodontitis-HPV association. It was shown that herpesvirus infections occurred more frequently in periodontitis sites and that herpesvirus-associated periodontal pockets harbored higher levels of periodontal bacteria. In addition, periodontal disease severity was significantly associated with salivary viral load, and periodontal treatment reduced the viral load to undetectable levels.20 It was suggested that periodontitis sites are a source of salivary herpesviruses and that periodontal treatment may help control viral replication, transmission, and associated diseases.11 Inflammatory diseases such as periodontitis also enhance HIV viral load because increased inflammation attracts HIV-infected lymphocytes and monocytes.21 In vitro experiments show that HIV replication is finely regulated by various inflammatory cytokines acting in autocrine and paracrine manner. Interleukins 1 and 6 and tumor necrosis factor α have been demonstrated to induce HIV expression and replication in latently infected, resting CD4+ T cells.20 Increased inflammatory infiltrate carries HIV- and herpesvirus-infected cells to the periodontitis sites, where cellular breakdown sheds viruses into the oral cavity.21 Saliva provides a means of interaction between shed viruses, bacteria, inflammatory mediators, and other carcinogens such as tobacco and alcohol metabolites.22 For example, bacterial production of acetaldehyde from ethanol is increased in patients with poor oral health.23 Saliva also provides a means of transport from one surface to another, promoting disease at distant sites.24 This may be related to the field cancerization in the head and neck region because more than 75% of oral cancers are found in saliva drainage areas.
The association between smoking and HPV prevalence in the literature is inconsistent. Although recent studies have shown that never-smokers tend to have HPV-positive tumors, most patients with HPV-positive tumors are still smokers.25 Therefore, defining a relationship between the virus, smoking, and other host and environmental influences may be essential to understand HPV-associated carcinogenesis. In our study, smoking alone was not a good predictor of tumor HPV status. All never-smokers had HPV-positive tumors, confirming the results of previous studies. However, more than half of the smokers also had HPV-positive tumors. Stratification by periodontitis history revealed that most of the never-smokers with HPV-positive tumors had periodontitis. Among smokers, those who had periodontitis were more likely to have HPV-positive tumors and those without periodontitis were more likely to have HPV-negative tumors. Periodontitis-HPV-alcohol use cross-tabulation yielded similar results, suggesting that the associations between HPV, smoking, and alcohol are modified by periodontitis. Therefore, stratification by local factors, such as chronic inflammation or bacterial infections, may provide valuable insights into the association of HPV with tobacco and alcohol use.
It is important to understand the difference between gingivitis and periodontitis, although both are commonly called "gum disease." Gingivitis is not a destructive process; it is reversible and affects everybody with poor oral hygiene. On the other hand, only a small subset of the population with poor oral hygiene develops destructive periodontitis, leading to epithelial migration and irreversible tissue loss.10,11 Factors that initiate periodontitis are not well understood. Recent evidence supports a significant role of viruses in the initiation and progression of periodontitis.10,11,18 Smoking reduces gingivitis, but it is a strong risk factor for periodontitis.10 A link between poor oral hygiene and HNCs has been suggested for a long time without a definitive answer.26 It is possible that among patients with poor oral hygiene, only those who develop periodontitis are at high risk for HNC. Clinical studies that include both patients with gingivitis and patients with periodontitis will allow testing of this hypothesis.
A strength of this study is that we had objective and quantitative documentation of periodontitis history before cancer diagnosis. The radiographs were taken at admission. However, detectable ABL on radiographs reflects preexisting longstanding periodontitis, often representing decades of history in older populations.10 On the other hand, we cannot conclude from this study that periodontitis preceded HPV infection. These 2 infections may have occurred concurrently, or HPV infection may have preceded periodontitis. A prospective clinical study or nested case-control study is needed to assess the temporal relationship of these 2 infections.
A disadvantage of secondary data analyses is that they depend on availability of data in adequate detail from preexisting medical records. In this study, limited information was available on covariates. For example, data on smokeless tobacco, diet, and sexual habits was not available. However, basic information on age, sex, race/ethnicity, alcohol and tobacco use, histologic confirmation of tumor diagnoses, sensitive assays to detect tumor HPV DNA, and quantitative and objective measures of periodontitis history was available.
Our study population was hospital based and consisted of patients with cancer, differing from the general population in a number of ways. Therefore, we cannot generalize our results and make inferences about the natural history of HPV infection in healthy populations. On the other hand, using a high-risk homogeneous population from the same source increases the efficiency of the study and reduces selection bias. We hope that the results of this study will stimulate other researchers who have access to larger populations, including cancer-free participants.
Years of research on specific microbial etiologies has not translated into effective treatment strategies for cancer. In most cases, the mere presence of a microorganism is not sufficient to cause cancer. In addition, biofilm formation by bacteria and the intracellular nature of viruses protect them from host defense and chemotherapy. Our approach is to clinically identify those infected individuals who are at a high risk of developing HNC. If periodontitis-HPV synergy is real, it will offer insights into the natural history of HPV infection and will translate immediately into clinical practices for improved prevention and treatment strategies. Currently, there is no treatment for HPV infection. On the other hand, treatment of periodontitis is safe and may reduce the acquisition, transmission, and persistence of HPV. The results of this study provide insights for larger studies, including clinical variables and biomarkers of periodontal disease.
Correspondence: Mine Tezal, DDS, PhD, Department of Oral Diagnostic Sciences, State University of New York at Buffalo, 355 Squire Hall, Buffalo, NY 14214 (email@example.com).
Submitted for Publication: May 23, 2008; final revision received August 1, 2008; accepted August 31, 2008.
Author Contributions: Drs Tezal, Sullivan Nasca, and Hyland had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Tezal and Loree. Acquisition of data: Tezal, Sullivan Nasca, Stoler, Smaldino, and Rigual. Analysis and interpretation of data: Tezal, Stoler, Melendy, Hyland, Smaldino, and Loree. Drafting of the manuscript: Tezal and Smaldino. Critical revision of the manuscript for important intellectual content: Sullivan Nasca, Stoler, Melendy, Hyland, Rigual, and Loree. Statistical analysis: Hyland. Obtained funding: Tezal. Administrative, technical, and material support: Tezal, Sullivan Nasca, Stoler, Smaldino, Rigual, and Loree. Study supervision: Melendy and Loree.
Financial Disclosure: None reported.
Funding/Support: This study was supported by grants 1R03CA119262 from the National Cancer Institute and T32-DE07034 from the National Institute of Dental and Craniofacial Research.
Previous Presentation: This study was presented at the Seventh International Conference on Head and Neck Cancer of the American Head and Neck Society; July 20, 2008; San Francisco, California.
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Originally written on
Backyard Sports Blog
Last updated 11/20/14
Today's hot chick is Josie Maran. Josie is an American model and actress. She's been in a couple smaller films and done some modeling, but she needs to make the big time. She's hotter than you know what, but I haven't really recognized her in anything big. Someone give this gal a shot. Pictures below.
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text:
LOL, that picture...
*ahem* Anyway . . .
Official Naruto Talkback Thread
Opening 1: Rocks (by Hound Dog)-01. Naruto Opening #1 Hound Dog - Rocks! - YouTube
Ending 1:Wind (by Akeboshi)-Naruto ending 1 - YouTube
Both the OP and the ED, along with all future Naruto OPs and EDs, can be downloaded in high quality from the Toonami Digital Arsenal.
Last time on Naruto:
No spoilers: No talk of future arcs, events, etc! All spoiler talk must be taken to the anime forum or through pm! Please have respect for all new viewers or else IT'S A TRAP will be coming for YOU. Believe it!
Enjoy the episode. Sleep is always for the weak.
There's a million ways to hush my voice
And a million ways to kill my thoughts
Maybe I'm all that you fear
I'm a stargazer
My eyes see differently - Blood Stain Child; "Stargazer"
LOL, that picture...
Random quote (changes once in a while)
"What could possibly be wrong with gaining knowledge and information?"
- Izzy, Digimon
My Twitter: https://twitter.com/AnimeExBurst
The title is a little misleading...
I've missed so many episodes. How will I ever catch up to these decade old episodes?
Last time? I don't know. I assume Naruto had a moment.
Of all the Naruto Uzumakis in the world, he's the Naruto Uzumakiest.
NACHOS CON CARNE | updates Mondays and Thursdays
POP CULTURE VOMIT BAG! | Latest review: Gremlins
Visit my new Internet animation blog NEVERENDING SATURDAY MORNING!
That's not the only thing he's fast at, Sakura.
Naruto, you definitely need to chill with the blushing. This tree has a limb you don't know about, brah.
Boy meets girl (actually a boy).
Oh, hai, Adult Swim.
4/1/12: Thanks to Adult Swim and Toonami, this date will live on as: Best. April. Fools. Day. Ever.
If there's one thing this show loves, it's androgyny.
Back off, dog! This is MY garbage!
To all the NaruxSasu fans, this is considered a love triangle.
Sasuke always has to win.
NACHOS CON CARNE | updates Mondays and Thursdays
POP CULTURE VOMIT BAG! | Latest review: Gremlins
Visit my new Internet animation blog NEVERENDING SATURDAY MORNING!
Wow. Even Naruto thinks men are more attractive than Sakura.
toonzone quick jump |


text:
1.0-9755: NVRM: Xid (0001:00): 16, Head 00000000 Count 0000000a
Since today, I'm getting messages like the following in my syslog: Code:
[...] Sould I care about these messages? Do they indicate some sort of failure? Code:
askwar@winnb000488 /var/log $ cat /proc/driver/nvidia/version Alexander |
Re: 1.0-9755: NVRM: Xid (0001:00): 16, Head 00000000 Count 0000000a
They could represent a potential problem. Are you experiencing any problems and if so, do you have a reliable means of reproducing them?
Also see: http://www.nvnews.net/vbulletin/showthread.php?t=46678 |
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text:
VOA of IL is happy to announce the second phase of the Hope Manor Project. In partnership with the City of Chicago and Alderman JoAnn Thompson of the 16th ward, a 101,298 square foot parcel of land has been secured for Hope Manor II.
Hope Manor II, a supportive, gender-responsive housing campus designed for Veterans and their children, will be home to more than 100 heroes. The Englewood complex will have a mix of single family town homes and condos built around a park and children's play area.
"This is the next logical step in our mission to secure housing for Veterans who are homeless or at-risk of homelessness," said Nancy Hughes Moyer, VOA of IL's President and CEO. "Where Hope Manor I focuses on single Veterans, Hope Manor II fills the need for Veterans with families."


text:
Reasons to choose us: 1. We are family running guesthouse by avid travelers who's everyday lives are deeply... Plus d'info »
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Okis inn is a renovated wooden guesthouse . It used to be a very old Kyoto style private house which was built 100... Plus d'info »
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Ryokan Q-beh is located in the historical district of "Gion" area where Maiko walk around, just a couple of minute... Plus d'info »
Located just 5-minute walk from Shijo station and Karasuma station, this guesthouse's easy transportation enables you... Plus d'info »
Tradition never fades away at this old town. Some travelers may ask us why you don't have a dormiotory room for... Plus d'info »
Guest House Kobako offers dorm rooms with bunk beds, as well as private Japanese-style rooms. Free Wi-Fi, rental... Plus d'info »
Guesthouse Shitamachi-Kujo is a warm place located in the south of Kyoto JR station. You will be able to reach many... Plus d'info »
The newest branch in Khaosan Hostel Group !! Khaosan Kyoto Theater is a comfortable and fun hostel where people... Plus d'info »


text:
Name: Thomas Sturman Annotation: Index from manuscript by Arthur Trader, Chief Clerk in the Maryland Land Commission, 1917. And see nos. 4507-4511, Land Notes. Source Bibliography: SKORDAS, GUST, editor. The Early
Settlers of Maryland: an Index to Names of Immigrants, Compiled from Records of
Land Patents, 1633-1680, in the Hall of Records, Annapolis, Maryland.
Baltimore: Genealogical Publishing Co., 1968. 525p. Repr. 1986. |


text:
Irish Internet Radio and TV from Dublin, Ireland.
Sort by:
Just a record. Reels: Coalminer's/Teampall An Gleant inn/The Boys Of Ballysodare Tags: Teampall An Gleant inn, Coalminer's KeyReel Fidléir Apr 28, 2010 102 views
Dubliners - Swallows Tail reel seen on 04 okt 2009 Eindhoven Netherlands Tags: okt, 04 lowieke de vos Dec 4, 2009 104 views
Athas performed at the Irish Cultural & Heritage Center in Milwaukee, WI on November 10th, 2007… Tags: fiddle, guitar Heather Lewin-Tiarks Nov 16, 2007 380 views
© 2015


text:
Umpqua Superfluoro LeaderSKU: 200-4-960-58710 From $12.95 Options:
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By Maureen O'Gara | Article Rating: |
April 15, 2013 07:00 AM EDT | Reads: |
5,557 |
Intel has started talking up its prospective new second-generation 64-bit Atom, a low-power x86 SoC called Avoton that's sampling now with OEMs, like HP apparently, and should be out and about in the second half.
Intel's been showing off the thing at the Intel Developers Forum in Beijing this week.
The device will be built into microservers before ARM gets its 64-bit processor with its enhanced virtualization and memory into servers early next year. It's got an integrated Ethernet controller.
ARM may be able to manage a 28nm process. If not, it's stuck with 40nm.
Intel expects to have four 64-bit Atoms available by the end of the year - earmarked for different systems and the three new widgets will be built on a 22nm process using the company's new Silvermont microarchitecture.
Intel hasn't copped to the power consumption of the Avoton yet but it's hoping to give ARM and its chip merchants agita.
The first-generation 64-bit Centeron Atom, built on Intel's 32nm process with its old core, ranged from 1.6GHz to 2GHz, with a thermal design power (TDP) of 6.1W to 8.5W.
Intel also has an Atom that was called Briarwood but, since it's available now, is officially the S12x9 and is intended for storage applications. It's supposed to good for as many as 40 lanes of PCIe 2.0 going in and out and improved RAID. Intel said MacroSAN, Accusys, Qsan, and Qnap are releasing systems based on the new storage chip.
Another little number coming later this year is the Rangeley, targeted at networking devices like mid-range routers, switches and security appliances
Published April 15, 2013 Reads 5,557
Copyright © 2013 SYS-CON Media, Inc. — All Rights Reserved.
Syndicated stories and blog feeds, all rights reserved by the author.
More Stories By Maureen O'Gara
Maureen O'Gara the most read technology reporter for the past 20 years, is the Cloud Computing and Virtualization News Desk editor of SYS-CON Media. She is the publisher of famous "Billygrams" and the editor-in-chief of "Client/Server News" for more than a decade. One of the most respected technology reporters in the business, Maureen can be reached by email at maureen(at)sys-con.com or paperboy(at)g2news.com, and by phone at 516 759-7025. Twitter: @MaureenOGara
Software is eating the world. Companies that were not previously in the technology space now find themselves competing with Google and Amazon on speed of innovation. As the innovation cycle accelerates, companies must embrace rapid and constant change to both applications and their infrastructure, and find a way to deliver speed and agility of development without sacrificing reliability or efficiency of operations.
In her Day 2 Keynote DevOps Summit, Victoria Livschitz, CEO of Qubell, discussed... May. 3, 2015 06:00 AM EDT Reads: 4,622 |
By Liz McMillan SYS-CON Events announced today that Vicom Computer Services, Inc., a provider of technology and service solutions, will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY. They are located at booth #427.
Vicom Computer Services, Inc. is a progressive leader in the technology industry for over 30 years. Headquartered in the NY Metropolitan area. Vicom provides products and services based on today's requirements... May. 3, 2015 02:00 AM EDT Reads: 2,362 |
By Liz McMillan SYS-CON Events announced today that Blue Box has been named "Bronze Sponsor" of SYS-CON's DevOps Summit New York, which will take place June 9-11, 2015, at the Javits Center in New York City, NY.
Blue Box delivers Private Cloud as a Service (PCaaS) to a worldwide customer base. Built on a technology platform leveraging decades of operational expertise in cloud and distributed systems, Blue Box Cloud is a managed private cloud product available in both hosted and on-prem versions. Each Blue Box ... May. 3, 2015 12:00 AM EDT Reads: 1,837 |
By Liz McMillan SYS-CON Events announced today that Soha will exhibit at SYS-CON's DevOps Summit New York, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY.
Soha delivers enterprise-grade application security, on any device, as agile as the cloud. This turnkey, cloud-based service enables customers to solve secure application access and delivery challenges that traditional or virtualized network solutions cannot solve because they are too expensive, inflexible and operational... May. 2, 2015 06:00 PM EDT Reads: 2,334 |
By Blue Box Blog As we recently previewed (read more about our London PoP in Jesse's post), Blue Box is opening a new Data Center in London, but hadn't announced the provider. Today we're excited to partner with TelecityGroup, whom we've selected as our data center partner in London. We chose their Powergate location, which is one of the U.K.'s most advanced, flexible and energy efficient carrier-neutral data centres.
Why does that matter to you? Well, when customers choose Blue Box, they're trusting us with ... May. 2, 2015 04:00 PM EDT Reads: 2,004 |
By Kevin Jackson Cloud computing seems destined to be the way enterprises will use information technology. The drastic cost reductions and impressive operational improvements make the transition an unstoppable trend. The "What is cloud computing?" question now, however, seems to be morphing into "Where is cloud computing going?"
While software-as-a-service (SaaS) providers see their market rocketing upward as the easiest and quickest path for cloud adoption, infrastructure-as-a-service providers are suffering... May. 2, 2015 03:45 PM EDT Reads: 779 |
By Pat Romanski How do you securely enable access to your applications in AWS without exposing any attack surfaces? The answer is usually very complicated because application environments morph over time in response to growing requirements from your employee base, your partners and your customers.
In his session at 16th Cloud Expo, Haseeb Budhani, CEO and Co-founder of Soha, will share five common approaches that DevOps teams follow to secure access to applications deployed in AWS, Azure, etc., and the frict... May. 2, 2015 02:00 PM EDT Reads: 2,343 |
By Alena Prokharchyk One of the most frequently requested Rancher features, load balancers are used to distribute traffic between docker containers. Now Rancher users can configure, update and scale up an integrated load balancing service to meet their application needs, using either Rancher's UI or API. To implement our load balancing functionality we decided to use HAproxy, which is deployed as a contianer, and managed by the Rancher orchestration functionality.
With Rancher's Load Balancing capability, users ... May. 2, 2015 01:15 PM EDT Reads: 2,046 |
By Roger Strukhoff The stack is the hack, Jack. That's my takeaway from several events I attended over the past few weeks in Silicon Valley and Southeast Asia.
I listened to and participated in discussions about everything from large datacenter management (think Facebook Open Compute) to enterprise-level cyberfraud (at a seminar in Manila attended by the US State Dept. and Philippine National Police) to the world of entrepreneurial startups, app deployment, and mobility (in a series of meetups and talks in bot... May. 2, 2015 01:00 PM EDT Reads: 2,158 |
By Yeshim Deniz ProfitBricks, the provider of painless cloud infrastructure IaaS, today released its SDK for Ruby, written against the company's new RESTful API. The new SDK joins ProfitBricks' previously announced support for the popular multi-cloud open-source Fog project. This new Ruby SDK, which exposes advanced functionality to take advantage of ProfitBricks' simplicity and productivity, aligns with ProfitBricks' mission to provide a painless way to automate infrastructure in the cloud.
Ruby is a genera... May. 2, 2015 01:00 PM EDT Reads: 1,692 |
By Ruxit Blog This is a no-hype, pragmatic post about why I think you should consider architecting your next project the way SOA and/or microservices suggest. No matter if it's a greenfield approach or if you're in dire need of refactoring. Please note: considering still keeps open the option of not taking that approach. After reading this, you will have a better idea about whether building multiple small components instead of a single, large component makes sense for your project.
This post assumes that you... May. 2, 2015 01:00 PM EDT Reads: 1,737 |
By Ruxit Blog This digest provides an overview of good resources that are well worth reading. We'll be updating this page as new content becomes available, so I suggest you bookmark it.
Also, expect more digests to come on different topics that make all of our IT-hearts go boom! May. 2, 2015 01:00 PM EDT Reads: 1,762 |
By XebiaLabs Blog There is no quick way to learn Jython API but to experiment with it. The easiest way is to start with Jytutor extension for XL Deploy.
Now you can also use the code snippet for exposing jython/python context in XL Deploy environment by running it directly in Jytutor
Here's how you can go ahead with that
Download the Jytutor extension referring to the Jytutor Blog or from the following link https://github.com/xebialabs-community/xld-jytutor-plugin/releases
Shutdown your XL Deploy server... May. 2, 2015 12:00 PM EDT Reads: 1,441 |
By Liz McMillan SYS-CON Events announced today that B2Cloud, a provider of enterprise resource planning software, will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY.
B2cloud develops the software you need. They have the ideal tools to help you work with your clients. B2Cloud's main solutions include AGIS – ERP, CLOHC, AGIS – Invoice, and IZUM May. 2, 2015 12:00 PM EDT Reads: 4,299 |
By Carmen Gonzalez SYS-CON Events announced today the DevOps Foundation Certification Course, being held June ?, 2015, in conjunction with DevOps Summit and 16th Cloud Expo at the Javits Center in New York City, NY.
This sixteen (16) hour course provides an introduction to DevOps – the cultural and professional movement that stresses communication, collaboration, integration and automation in order to improve the flow of work between software developers and IT operations professionals. Improved workflows will res... May. 2, 2015 11:30 AM EDT Reads: 3,152 |
By Elizabeth White Chef and Canonical announced a partnership to integrate and distribute Chef with Ubuntu. Canonical is integrating the Chef automation platform with Canonical's Machine-As-A-Service (MAAS), enabling users to automate the provisioning, configuration and deployment of bare metal compute resources in the data center. Canonical is packaging Chef 12 server in upcoming distributions of its Ubuntu open source operating system and will provide commercial support for Chef within its user base. May. 2, 2015 11:00 AM EDT Reads: 2,455 |
By Elizabeth White SYS-CON Events announced today that MangoApps will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY., and the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA.
MangoApps provides private all-in-one social intranets allowing workers to securely collaborate from anywhere in the world and from any device. Social, mobile, and eas... May. 2, 2015 11:00 AM EDT Reads: 4,221 |
By Carmen Gonzalez SYS-CON Media announced today that @ThingsExpo Blog launched with 7,788 original stories. @ThingsExpo Blog offers top articles, news stories, and blog posts from the world's well-known experts and guarantees better exposure for its authors than any other publication. @ThingsExpo Blog can be bookmarked. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. May. 2, 2015 11:00 AM EDT Reads: 3,257 |
By Liz McMillan There is no doubt that Big Data is here and getting bigger every day. Building a Big Data infrastructure today is no easy task. There are an enormous number of choices for database engines and technologies. To make things even more challenging, requirements are getting more sophisticated, and the standard paradigm of supporting historical analytics queries is often just one facet of what is needed. As Big Data growth continues, organizations are demanding real-time access to data, allowing immed... May. 2, 2015 11:00 AM EDT Reads: 5,434 |
By Lori MacVittie Lacking the traditional fanfare associated with any technology that can use the word "container" or mention "Docker" in its press release, Ubuntu Core and its new Snappy system management scheme was introduced late last year. Since then, it's been gaining steam with Microsoft and Amazon and Google announcing support for the stripped-down version of the operating system.
Ubuntu Core is what's being called a "micro-OS"; a stripped down, lean container-supporting machine that's becoming more pop... May. 2, 2015 11:00 AM EDT Reads: 804 |


text:
Hotel del Lago
- Continental Breakfast
- Outdoor pool
- Swimming pool
- Room service
- Restaurant
TripAdvisor Reviews Hotel del Lago Cavriglia
Travel Blogs from Cavriglia
Michelangelo's Point of Florence
In the morning I went bag shopping with Oma. It was actually really touching to see how much she cared for her family. Whenever we went anywhere she would always be thinking of things to get her siblings and cousins.
We then decided to visit all the fancy shops in Florence just for the heck of it. Only later did I realize that the hole in my stocking was ginormous so probably the store owners ...
On to Florence!
... helped me get mine up on top of a pile of suitcases. This area is for the larger luggage but I didn't realize that until later.
I'm in Business class (only $40 dollars since I purchased the ticket well in advance), where there are only 3 seats in each row, 2 on one side, a single seat on the other. Each seat has a tray-like table in front of it that is shared with the seat facing it. I was in a single seat across the aisle from 2 couples. They had ...
Kicking it in Florence, Soave and Milan!
... venture in as we have heard its all pretty overpriced and not handmade like it was historically. Hannah then wanted to go and photograph some "pretty gardens" (aka Biboli Gardens - which were recommended to Hannah by her friends - Hannah's contribution) so we went to go into a massive palace that was owned by the famous Florence family called the Medici family which has some pretty vast and beautiful gardens. Once again, have a look at the photos that we have put with the ...
Bella Italia
... to spare until midnight.
Trying to reach the city center I ended up at a bus stop. After a while, I started to suspect no more busses would be coming, and I asked a passing woman about this. She confirmed my fears and asked me where I was going. When she found out that I had nowhere in particular to go she grabbed my arm and brought me to her home, where she gave me some dinner and let me stay the night. The next morning was an early one, since both she and ...
A day in town
... did not have face cradles and they offered a standard bath towel for a top sheet. She did provide abdominal work, but forget about a breast drape. And she took a phone call, and not a super brief one either, but the really odd thing (yes, it could get more odd) a coworker just walked right in to get something and have a conversation. I should also insert here that Italians enjoy speaking with their hands so I recieved allot of incidental touch during ...


text:
Preview Image |
Item images are no longer available |
Currently | $6.00 USD | |
Item ID # | 15872747 | |
Quantity | 1 | |
Start Time | 3/17/2014 8:41:22 AM PT | |
End Time | 3/24/2014 8:41:22 AM PT | |
Seller | Goodwill of Greater Grand Rapids | |
Location | Grandville, MI | |
Payment | MUST BE RECEIVED WITHIN seven (7) DAYS from auction close. Available Payment Methods: |
Shipping / Handling | Buyer pays shipping No International Shipments This item ships via Shipment Cannot Be Combined With Other Items Shipping Weight 3 lbs. Get Estimated Shipping & Handling Minimum shipment weight is 1lb., items weighing less than 1lb. will be calculated at the 1lb. rate. Items are shipped using a major carrier usually within 5 business days after receipt of payment. Shipping charges are calculated at payment time. A handling fee of $2.00 applies to this item, regardless of delivery method including pick up. |
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Pewter Serving Tray w/ Lady Art Deco Current Price: $24.00 Seller: Goodwill of Greater Grand Rapids | Vintage Toy Fire Truck With 3 Figurines Current Price: $60.99 Seller: Goodwill of Greater Grand Rapids | Golden Cockerel Black Nesting Dolls Current Price: $8.00 Seller: Goodwill of Greater Grand Rapids |
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Item Description Precious Moments Doll By Samuel Butcher 1991. Made in USA. Dimensions 17 1/4". Condition Notes Signs of wear. No chips or cracks. Black marks. Shipping Method: UPS |
(Store: /29X)
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Goodwill of Greater Grand Rapids3035 Prairie SW Grandville, MI, 49418 616-532-4200 ext 1185 |
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Merchandise is sold As Is. Returns will only be accepted with prior authorization and under the terms stated in this Return Policy. If you have questions regarding the quality or authenticity of this item please contact Goodwill of Greater Grand Rapids prior to placing your bid. Items may be returned within seven (7) days of receipt if the merchandise was damaged during shipping or if there was a major distortion in the description. Returns will not be accepted without prior authorization. PLEASE NOTE THAT WE DO NOT REFUND SHIPPING AND HANDLING CHARGES. Items selected for pick up from the seller, must be picked up within thirty (30) days from close of auction. Items paid for and not picked up from seller within thirty (30) days from close of auction will be considered a donation (with no refund) and resold with no further notice.