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NIH awards new $14.5 million, five-year grant to the Scripps Research Institute
Part of NIH Roadmap Initiative, grant will be directed toward membrane
The Scripps Research Institute announced today that it has been awarded a $14.5 million, five-year grant from The National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH). The grant, which is titled "JCSG Center for Innovative Membrane Protein Technologies," funds structural biology research on membrane proteins�an area of immense medical potential.
Now that the human genome and the genomes of dozens of different organisms have been solved, scientists all over the world are busy analyzing this genetic information. An important part of this analysis are efforts that look at how genes are expressed as proteins. Structural biology is an important part of this research because its outcome, high-resolution three-dimensional structural information, provides insights into the correlation between protein structure and function. Some day scientists may be able to interpret and catalog the structures and functions of all the proteins in the human body, which will reveal a wealth of information on the biology of human health and disease.
"Everybody feels that structural biology needs better tools for producing certain types of proteins, particularly for membrane proteins," says Scripps Research Professor Raymond Stevens, Ph.D., who is the principal investigator on the new grant.
Stevens has spent the better part of the last decade developing high-throughput structural biology tools. He has found that solving structures has become much easier and faster in general, but there are still certain types of proteins that present technological challenges that must be overcome before they yield to high-throughput methods. These include eukaryotic proteins, proteins that are involved in interactions with other proteins, and integral membrane proteins -- a mere fraction of the structures contained in the Protein Data Bank are of integral membrane proteins, despite the fact that more than a third of all proteins in the body are in the membrane.
Membrane proteins are of particular interest because of their enormous medical potential. A large proportion of all drugs on the market target membrane proteins. The goal of the new grant is the development of rapid, efficient, and dependable methods to produce membrane protein samples that scientists can use to solve structures and investigate physiological functions associated with those three-dimensional structures.
The new grant pulls together a group of scientists at Scripps Research, including several who were already involved in a thus far highly successful large project developing high-throughput technology for structural biology. This project, the Joint Center for Structural Genomics (JCSG), is also sponsored by the NIH and is led by Scripps Research Professor Ian Wilson, D.Phil. (For more information on the JCSG, see a related News&Views story: http://www.scripps.edu/newsandviews/e_20010226/jcsg1.html or the JCSG home page: http://www.jcsg.org/).
The grant is part of the "roadmap" that NIH Director Elias Zerhouni announced last year as a guide for medical research in the twenty-first century. A series of far-reaching initiatives designed to transform the nation's medical research capabilities and speed the movement of research discoveries from the bench to the bedside, the NIH Roadmap provides a framework of the priorities the NIH must address in order to optimize its entire research portfolio and lays out a vision for a more efficient and productive system of medical research. (For more information, go to: http://nihroadmap.nih.gov/).
"It is an extremely important grant," says Scripps Research Professor Kurt W�thrich, Ph.D, an investigator on the grant and the recipient of the 2002 Nobel Prize in Chemistry. "It fills a very important gap in the whole proteomics field."
Other Scripps Research faculty members involved in the grant include Assistant Professor Geoffrey Chang, Ph.D., Associate Professor M.G. Finn, Ph.D., Associate Professor Peter Kuhn, Ph.D., Professor Wilson, Professor Mark Yeager, M.D., Ph.D., Assistant Professor Qinghai Zhang, Ph.D., and Assistant Professor Scott Lesley, Ph.D. Lesley is also the Director of Protein Sciences at the Genomics Institute of the Novartis Research Foundation (GNF). Chang, Finn, Wilson, and W�thrich are all members of The Skaggs Institute for Chemical Biology at The Scripps Research Institute.
Structural Biology and Membrane Proteins
Ideally, one would like to be able to stick a molecule under a microscope, look through the eyepiece, and, to paraphrase the late physicist Richard Feynman, just look at the thing.
A lot of biology can be understood simply by seeing what a molecule looks like, but the scale of biological molecules is extraordinarily small. All but the largest molecular complexes are considerably smaller than the wavelength of visible light, which means that scientists who want to know what an individual membrane protein "looks" like in nature have to rely on some other type of biophysical analysis.
Currently, three fundamental technologies are used for solving the three-dimensional structures of proteins and other biological molecules: x-ray crystallography, nuclear magnetic resonance (NMR), and electron microscopy. Scientists have used these techniques to solve the structures of tens of thousands of biological molecules.
Electron microscopy has been in use since the 1930s and relies on the use of magnetic lenses that bend a beam of electrons to image biological molecules and other tiny objects. Electron microscopy looks at a range of magnifications, from 60 times (the level of an ordinary light microscope) to 1,000,000 times. The final products of these electron images are representations of the biological structures at near-atomic resolutions -- up to about 3 to 4 angstroms under the best of circumstances. That's not quite fine enough to resolve individual atoms in the structure, but more detailed structures can be modeled by combining electron microscopy with the higher-resolution techniques of x-ray crystallography and NMR.
X-ray crystallography is a technique in which a protein or some other molecule is carefully manipulated so that a crystal can form. This crystal, which is really just a large array of the molecules in solution, is then placed in front of a beam of x-rays, which diffract when they strike the atoms in the crystal. Based on the pattern of diffraction, scientists can reconstruct the shape of the original molecule.
NMR refers to the ability of atomic nuclei to reorient in a magnetic field when exposed to radiation of a particular "resonant" frequency in the radio band. An NMR spectrometer will scan a broad range of radio frequencies and record small but measurable induced voltages caused by the movement of atomic nuclei in the NMR as they go in and out of resonance. The spectrum is influenced by the shape of the molecule in which the resonating atoms reside, and scientists can use the NMR spectrum of a protein to determine its three-dimensional structure.
The three techniques have coexisted for a generation, and more and more, structural biologists have been moving beyond focusing on one technique or another to focusing on the problems that they can solve. The problem, to a certain extent, may determine the technique used. Smaller proteins may be most easily solved by NMR, larger proteins may require crystallography, and very large protein complexes may be done by electron microscopy or a combination of crystallography and electron microscopy.
"At the end of the day," says Stevens, himself a crystallographer by training, "you don't really care whether it is NMR, x-ray crystallography, or electron microscopy -- you just want the structure."
In the last few years, all three techniques have been applied to solving membrane protein structures, as the work of a number of investigators at Scripps Research exemplifies:
- Using electron microscopy, Yeager and his colleagues solved and published the structure of the heart gap junction channel in a cover article in the journal Science in 1999. Heart gap channels are the specialized pores that join together heart muscle cells and allow these cells to depolarize at about the same time so that the heart beats as one single tissue and not as a loose collection of cells.
- Chang has had success using x-ray crystallography. In 2001, he published the structure of the membrane protein in a cover article in the journal Science that provided the first detailed glimpse of a membrane transporter protein -- a type of large protein that sits in the cell membrane and moves other molecules in and out. Cancer cells resist chemotherapy by using these transporters, and bacterial cells use them to resist antibiotics.
- In 2002, the Stevens laboratory, in collaboration with Benjamin Cravatt's laboratory at Scripps Research, published in Science the crystal structure of the integral membrane protein fatty acid amide hydrolase at 2.8A resolution. Fatty acid amide hydrolase degrades endocannabinoids, molecules involved in pain signaling, and is a current drug target of several pharmaceuticals companies.
- W�thrich and his colleagues applied NMR to membrane proteins suspended in large soap-like micelles, which mimic the membrane and preserve the fold of the proteins. "You can't do conventional NMR on such things," says W�thrich. Luckily, he and his colleagues have also been working on a technique called transverse relaxation-optimized spectroscopy (TROSY) that enables NMR to be applied to larger molecular structures.
In general, though, solving membrane protein structures has been successful only where scientists have overcome the technical challenge of producing and purifying the membranes.
The Trouble with Membrane Proteins
The main problem with using conventional techniques in structural biology to solve membrane proteins is simple and twofold-- membrane proteins are hard to produce and are usually unstable once they are produced.
The easy solution to the problem is to do what structural biologists have done for decades -- ignore membrane proteins and work on something else.
Scientists have gotten around the problem for years with tricks like lopping off the portion of the protein that is on the outside of the cell membrane and solving it as one would any soluble protein. But the problem with this is that it ignores what happens inside the membrane -- where some of the most important biological action is.
The difficulty with solving membrane proteins starts with obtaining them. A crystallographer might need several milligrams of protein, but membrane proteins do not express well naturally. They only make up a small part of the membrane, and the membrane is only one small component of the entire cell.
In fact, says Stevens, "When you express membrane proteins at high levels, they are extremely toxic to the cell."
Even assuming success in producing sufficient quantities, many of these proteins are only stable when they are in the membrane, so they must be purified in the presence of detergents or lipids that act like a membrane, surrounding the proteins' membrane-spanning regions with detergent molecules. The conditions under which this has worked in the past are highly sensitive to such variables as detergent type, concentration, pH, and ionic strength. And these conditions are also almost always unique, demanding a lengthy trial and error search for those exact conditions in which the protein-detergent complexes will be soluble and stable. In addition, the costs of the detergents alone can easily add up to hundreds of thousands of dollars.
"The preparation of membrane proteins in the quantities and qualities needed to do structural studies is an unsolved problem," says W�thrich. "And we hope to solve it."
Addressing the Problem
The new grant will address these central problems of membrane production and membrane stability. The Scripps Research team will examine several approaches.
On the production side, they will look at improved expression of membrane proteins by using insect or mammalian cell systems. "We know that membrane proteins will express in mammalian cells -- we've done that already," says Stevens.
Yeager will be focusing on the expression of membrane proteins in mammalian and other types of eukaryotic cell lines. Eukaryotic cell lines have the advantage over bacterial cells in that they have all the enzymatic machinery in place that allows the membrane proteins to fold and assemble properly.
But, because these technologies can be expensive and time-consuming, the team is also looking at a technology that Chang and others have been developing called in vitro expression. In vitro expression does not use a cell at all, but basically takes all the components of a cell that make up the protein expression machinery -- such as the genes, amino acid building blocks, and enzymes�and puts them all together in a test tube under conditions that favor expression.
In vitro expression has been used to make membrane proteins in a few limited cases, but it is far from routine. Chang calls the technique high risk and high impact. "If it works, it could revolutionize the field," he says.
In addition to addressing the problem of protein production, the grant will support a number of approaches to addressing the problem of protein stability.
One approach will be to build on the work that has been done using other proteins to help stabilize the membrane proteins. While this technique has been used before, there has never been a generalized approach to creating such a scaffold. As part of the grant, the team plans to synthesize and test a matrix of new molecules to stabilize integral membrane proteins.
Finn and Zhang will be synthesizing new lipids and detergents and helping to determine the right sorts of lipid/detergent/protein mixtures for membrane proteins. Eventually, they will scale up to several hundred different lipids and detergents, from which the best will be selected. Large quantities of these will then be produced, says Finn.
In the end, scaling up is one of the primary goals -- in other words, developing the tools that will allow membrane proteins to be produced so that membrane protein structures can be solved rapidly.
"Ten years ago, people thought it would be very difficult to solve kinase structures. Now they are being solved left and right," says Stevens. "The same could happen with membrane proteins -- we just need that technological breakthrough to unleash it."
Source: Eurekalert & others
Last reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
Published on PsychCentral.com. All rights reserved.


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mp3classicalmusic |
Jan Ladislav Dussek |
Časlav (Czech R.) 1760 Saint-Germain-en-Laye 1812 |
Sonatinas for Piano Sonatina in G Major op.20 n.1
I - Moderato (5'58")
Sonatas for Piano Six Sonates faciles pour le Piano Forte, Op. 46 Sonata in C Major, Op. 46 No.1 II. Andante moderato con Variat. (5'40") Sonata in F Major, Op. 46 No. 2 II. Rondo. Allegro moderato (3'04") Sonata in B flat Major, Op. 46 No. 3 Sonata in C major, Op. 46 No. 4 Sonata in D Major, Op. 46 No. 5 Sonata in G Major, Op. 46 No. 6 II. Tempo di Minuetto con Variazioni (5'05") All the tracks performed by Claudio Colombo, on Yamaha digital pianos. Free music scores of Jan Ladislav Dussek's works on imslp.org |
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subset: commoncrawl


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Reviews for Roma Pizza & Grill
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Bucky lovington posted on 10/17/2013
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I saw one of the cooks go work across the street at the pawn shop they also own, when he came back he did not wash his hands before preparing food! This is a major health code violation!
posted on 04/04/2009
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Best authentic tasting pizza around... like real New York pizza!
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Jesse H. posted on 12/27/2014
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Very nice staff, good food and very reasonable prices. This is where I spend my money when I want decent Italian locally. read more
Java L. posted on 09/20/2014
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Decent New York style pizza. Otherwise, nothing fancy, with service at an Appalachian pace. I like it for carry out. read more
Cielo P. posted on 07/06/2013
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I know this is an Italian place, but I only go here for the wings. Seems like lately, a lot of the wings you get are fatty and soggy, with tons of... read more
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Pirate Rattle
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Maileg Pirate rattle with an embroidered face, a striped outfit, arms and ears. Measures 16cm x 5cm, and is suitable for children aged 0-3 years.
This cute rattle from Maileg is perfect for stimulating young minds and developing imaginative thinking. The retro style toy will look great on display, whilst the noisy rattle will give your little budding pirate hours of joy. If you like this take a look at the Rainbow Paddington Bear Stroller Book and the Tartine et Chocolat Cream Hedgehog Rattle
Product Code: MAIL52114101-52


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- 01-04-2014, 06:00 PM Thread Author #1
Acer to release 27" Android flat PC/touch-monitor
The all-in-one systems can be used as displays for Windows machines, but Acer is billing them as primarily Android devices. The 27-inch TA272 ($1,100) and 21.5-inch DA223 touchscreen all-in-ones come with the last-but-one version of Android, aka Jelly Bean, are powered by quad-core Nvidia Tegra and Qualcomm Snapdragon 600 processors, respectively, have the usual grab bag of USB and HDMI ports, and are Windows 8�certified."All information is imperfect. We have to treat it with humility."
- The Ascent of man.
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MPN: | 6x9PR | Brand: | Atrend |
Speaker Size: | 6" x 9" | Model: | 6x9PR |
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Pair of New 6X9" Angled MDF Speaker Enclosure Hatchback Box for Car Truck StereoClick on Thumbnails to Enlarge* Free Shipping is only for residential or commercial destinations within the continental 48 United States. Shipping to PO Box addresses are not free and additional charges apply. Additional Shipping to AK, PR, HI, VI apply and send us a message to get a shipping quote * We only ship the item to the PayPal Verified address that is sent to us at the time of checkout. Please verify the correct shipping address in your PayPal account before making your payment. If we ship your item to an old or invalid address and you are not able to locate the item, we are not responsible for replacement. * Most of our items do not ship to APO/FPO/PO Boxes. * Most of our items are shipped via FedEx, UPS or USPS. * Vortex Audio new extended return period is 60 days. All returns require a Return Authorization (RA) number issued by an authorized Vortex audio representative. Please send us a message via ebay message system to receive RA #. Product returned without this authorization will be refused. An RA is only effective for ten (10) days from issuance. * Defective Returns. Defective product can be returned to us within 60 days of sale. After 60 days, defective product must be returned to the manufacturer, under the specific warranty. Customer is responsible for return freight costs as we will cover for replacement item freight cost. Blown subwoofers/ speakers doesn't cover under return program. * Non-Defective Returns. a. All non-defective returns will be assessed a 15% restocking fee, if product ordered is returned within 30 days of purchase. Handling fees and freight charges will not be refunded. b. The RA number must be printed clearly on outside of the carton, and all products must be securely protected in double packaging. If the RA number is not visible, the shipment may be refused. If shipping labels are placed on or RA numbers written on the manufacturer???s boxes, the product will not be in resalable condition, and, in turn, will not be eligible for return. All original packaging and materials, including all parts, accessories and instruction manuals from the manufacturer must be returned with the product. Failure to comply may result in charge-backs, penalties and/or other fees to the customer, up to and including denial of RA credit. We Accept, * Paypal * Bill Me Later * Visa * Mastercard * Discover * American Express If you have any questions regarding specific payment options please don't hesitate to contact us. At VortexAudio, we specialize in a wide variety of products including car audio and installation products, consumer electronics, home audio, and sporting goods. We have been in business since 1999 with vast experience in excellent customer service, technical support and product knowledge. We bring excellent pricing for all the products we carry. Vortex Audio negotiates best pricing with vendors and passes alone the saving to you. Our goal is to deliver quality products to our customers at the lowest pricing with excellent customer service. Ship with us and come back for the same great service. Thank you for visiting the VortexAudio eBay store. * For International customers, we only accept Paypal as the payment option. * Any brokerage, customs, and duty fees associated with international shipments are customer's responsibility. * For International Orders, a phone number is required for the customs documents. Failure to provide one will result in delays. No Invoices are sent with our shipments, if you need an invoice , please let us know. we can email one for you. |
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What holiday is closest to your babies birthday?
What holiday is closest to your babies birthday?
*Proud mommy of 4 amazing children and happily married to my high school sweetheart*
Quoting Kaylahk:DS was born Dec 31st 2012 at 8:04 pm. He was 4 hours from being the new years baby lol! so my answer is New years!
Wow! So close, LOL
My cousin was born on New Year's Eve but she was born in the morning.
This was my second baby to be born on 'Fat Tuesday'. Her birthday is also 2 days before our wedding anniversary.
DS1 April 26th, so Easter or Mother's Day depending on when each of them fall. Or Cinco De Mayo? lol.
DS2 September 6th, so Labor Day?
DS3 July 31st, so The Fourth of July.


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Dispose Of Your Rx Drugs At Saturday Drug "Take-Back" Events
Do you have any old or expired drugs in your medicine cabinet? This weekend you'll have the chance to dispose of them safely. Saturday is National Prescription Drug Take Back Day.
Scandrick 'Excited' To Return To Cowboys
Scandrick arrived at at the club's Valley Ranch headquarters this morning and rejoined the team as the result of the NFL reaching an agreement with the NFL Players Association on changes to its performance-enhancing drug policy.
Feds: 21 Arrested In Texas Aryan Brotherhood Drug Ring
Authorities in Texas say they've arrested 21 members of the Aryan Brotherhood prison gang in an alleged conspiracy to sell methamphetamine.
Officer Fires At Suspect After Being Hit By Car
A police officer in Dallas was injured on Sunday night after being tossed onto the hood of a vehicle being driven by a suspect who was thought to be making a drug sale.
Texas Man Gets 20 Years In Synthetic Drug Deaths
A Texas man accused of selling synthetic drugs in every state and distributing the chemicals that resulted in the overdose deaths of two North Dakota teens was sentenced to more than 20 years.
Weapons Smuggler Receives Almost 8-Year Prison Term
A man from Laredo was sentenced to almost 8 years in prison after he pleaded guilty to a weapons charge for trying to smuggle weapons to Mexico's Zeta drug cartel.
New Nail Polish May Detect Date-Rape Drugs
Undercover Colors nail polish changes color when in contact with Rohypnol, Xanax and GHB so a person knows when to drink or dump a beverage.
Execution Drug Cost Quadruples For Texas Prisons
The Texas prison agency is paying four times more for its execution drugs from a new supplier.
Feds: East Texas Man's Murky Death Tied To Drugs
Federal authorities have arrested a man suspected of selling drugs to an East Texas man whose mysterious disappearance prompted his family to criticize investigators for mishandling the case.
Pot Brownies May Land Texas Teen Life Sentence
A 19-year-old man who could face years in prison for making brownies laced with marijuana and hash oil said Wednesday he remains scared despite new evidence that his attorney believes should reduce the charges.
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Whether pro athletes are using steroids to gain an edge on the field or recreational drugs or booze to lose their edge off of it, stories of pro athletes getting caught up with drugs or alcohol seem to always be in the headlines.
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Law enforcement officials on Thursday found nearly 1,300 marijuana plants growing in a very rural part of Navarro County, along with a recently used campsite nearby.


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Last night I lay in bed
My gut sick and sour
pounding in my head
tragedy struck this hourKnowing something was not right
the void of not knowing
kept awake half the night
while red lights were glowingWhile the world lay sleeping
we are alert and awake
vigilant guard he was keeping
making no mistakeAll of us connected by fate
a brother now laid
forever to rest on this date
his oath and promise be paidSt Michael Protect Us ...
For we fight the good fight
leaving our families behind
kissing them good night
going back to the grindPut ourselves in harms way
so that others may rest
knowing we keep evil at bay
being the best of the bestThe blue line has been stained
with the blood of a brother
all feel sorrow and are pained
all feel the loss of anotherSt Michael Protect Us ...
Hunt them down we yell
none will take rest
find the evil from hell
desecrated our crestBlack band across shield
blue blood ties us together
great strength we do wield
stay strong in bad weatherWHEN ONE FALLS, WE ALL FALL ...
St. Michael Protect ALL of US ...
Jonathan C Thomes


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text: Loni Love's Man is Here! 01.14.14 :: Filed Under: Celebs :: Comments She's told Ellen all about him, but Ellen had a surprise for Loni today! Meet Loni Love's handsome man, Sam. Related Videos Loni Love on 'The Bachelor,' Kanye West, and the Pope Loni Love on Christian Mingle Loni Love on 'One Direction' Loni Loves 'The Bro Show' Loni Love Catches Up with Ellen Loni Love's Love Loni's Love and Dating Advice Comments


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Westview Disc Golf Course
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Rec course with some challenging holes along a creek. OB is any blacktop, walkway bridges, and over any fence.
Course Details
# Holes: 12
Target Type: Mach II
Tee Type: Concrete
Elevation: Flat
Foliage: Sparse
Course Length: 4,153ft
Alternate Length: 3,592ft
Hole Length: Under 300ft: 4 | 300 - 400ft: 6 | Over 400ft: 2
Go west from center of town on 2nd St NW. Pull into parking lot on south (left) side of street when you get to about 10th St.
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(-96.334026,44.001243 )
Email: Dennis Boese
Phone: 507-825-2102
Alt. Phone: 507-825-3333
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After spending years making money on display as a heavy-weight champion, Mike Tyson has decided to take some time and make some money talking about his years on display as a heavy-weight champion.
The 46-year-old ex-gladiator has hit the stage at the Hollywood Theatre at MGM Grand in Las Vegas. The show takes place from April 13-18 and touches on Tyson's experiences in the ring and the unrestrained drama behind the scenes.
Lately, Tyson has been no stranger to the entertainment industry. This new theatrical exploration follows several big-screen appearances, including the documentary, Tyson, as well as The Hangover trilogy, the third of which is expected to drop into theaters next year.
Sporting a classic pairing of white tux and massive face tattoo, Tyson will take to the stage each night with a backup singer and a five-piece band.
"Many of you wondered what the hell Mike Tyson was going to do on stage tonight," Tyson announced in the third person to an audience of people, each individually wondering what exactly they paid $117.49 to see. "I was wondering the same thing."
The confused audience then listened as Tyson went on a two-hour scripted, yet heart-felt spiel, laying out his past. The performance includes details on his alcoholic mother, his cocaine use, and his tendency for Japanese prostitutes.
The show is said to boldly steer from Tyson's fighting triumphs and right into the embarrassing holes of his career low-points, including the whole ear-biting incident. (Come one, did you really think I could get though this whole thing without mentioning the ear?)
So far, audiences seem happy, but they might just be clapping out of fear of what would happen if they didn't.


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May 1, 2011
Coffee Break: When the Public Came Through for Your Organization
In your space, you tell us about times when your community stepped up to support your organization when it faced adversity: pet food shortages, budget cuts, major fires, even hurricanes.
March 1, 2011
Field Trip: Making the Mean Streets a Little Kinder
Initially created to serve street people and their four-legged companions, the Portland Animal Welfare (PAW) Team now provides veterinary care to nearly 150 animals at its monthly clinic.
March 1, 2011
Someone to Watch Over Me
As wounded soldiers return from Iraq and Afghanistan, military and veterans' hospitals around the country are increasingly using a variety of canine-assisted therapies to heal their scars.
January 1, 2011
A License to Succeed
Calgary's mandatory licensing program for dogs and cats not only produces nearly enough revenue to cover the cost of providing animal services to a city of 1.1 million people, but also enjoys widespread buy-in from the public.
January 1, 2011
People Power: Skilled with a Scalpel
A spay/neuter veterinarian takes his commitment to ending pet homelessness to new heights.
January 1, 2011
Readin', 'Ritin', and Rabbits
A college in California combats a longstanding bunny overpopulation problem with a unique TNR/adoption program.
January 1, 2011
Shelter Medicine: The Kindest Cut of All
Veterinary columnist Brenda Griffin addresses common questions and concerns about pediatric spay/neuter, as well as the immeasurable value it has in curtailing pet overpopulation.
November 1, 2010
People Power: Choosing a New Path
After participating in a puppy mill raid, a longtime sheriff decides to leave law enforcement and become manager of the county's new shelter for dogs.
November 1, 2010
Field Trip: Homeless in Paradise: Helping Mexico's Strays
Mexico may not be a tropical paradise for the country's homeless animals, but local groups are lending a hand and making a difference.
November 1, 2010
Making Spay/Neuter an Inside Job
A program in Oklahoma provides a model for how subsidized spay/neuter can be made more widely available to low-income residents, through cooperative efforts with local veterinarians in private practice.


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Half of businesses using Microsoft's SharePoint collaboration tool are frustrated with the solution, according to research carried out by Vanson Bourne.
The research shows that 87 per cent of businesses overall, and 92 per cent of enterprises with 3,000 or more employees, have deployed Microsoft's SharePoint solution.
However, 22 per cent of respondents are frustrated with the solution's poor user interface, while 51 per cent overall, and 64 per cent in the financial sector, complain that the software requires a high level of customisation.
"The bottom line is that collaboration technologies are being deployed to give users productivity gains," said John Safa, vice president of engineering at document collaboration software provider and Microsoft partner Workshare, which commissioned the research.
"So, if they aren't easy to use and users aren't adopting the systems, that investment is wasted. These solutions are meant to help employees get their jobs done more quickly."
The research surveyed 100 UK CIOs, IT directors and senior IT professionals at enterprises with more than 1,000 employees.
There is a lot of attention being paid to how business leaders can use the mobile computing preferences of employees and customers to be more responsive, efficient and successful. This white paper runs through five security considerations for the mobile age.
This Dummies white paper will help you better understand business process management (BPM)


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Rarely has one statement prompted such a dramatic move in currency markets.
Baku. Durban. Oman. Sri Lanka. Chengdu. Danang. No this is not the list of datelines with tragic headlines from today's news. These are places you should go.
Target is giving up on Canada.
WEEK IN RELIGIONGermany�s iconic Cologne Cathedral went dark Jan. 5 to protest an anti-Muslim march held by the Patriotic Europeans Against the Islamisation of the West group.
During an otherwise uneventful city council meeting Tuesday at 5 p.m. Eldorado Mayor Rocky James publicly thanked Eldorado discount store Fred's for donating $189 to both the Eldorado Fire Department and the Eldorado Police Department.
Open since this last November, Crossfit Little Egypt is well on the way to being the premier cross training center in our area.
Saline County Soil and Water Conservation District holds its 68th annual meeting 6:30 p.m. Monday at the Eldorado High School cafeteria.
Sign up for our newsletter and have the top headlines from your community delivered right to your inbox.
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Corpus Christi Country Club
- 6300 Everhart Rd, Corpus Christi, TX 78413
- www.cccountryclub.com
18 total holes at facility |
Green fees - $85 to $100 (estimate) |
Designed by Robert Trent Jones |
Built in 1965 |
Bermuda Grass |
Driving Range: Yes |
Private golf course |
Corpus Christi Country Club is an 18-hole regulation length golf course in Corpus Christi, Texas. This medium-length layout features 4 sets of teeboxes for the enjoyment of golfers of all skill levels. Online tee times may be available at Corpus Christi Country Club or at nearby golf courses, usually offered at a discount from the normal rate.
Tees | Par | Yardage | Course Rating | Slope |
Back | 72 | 6494 | 72 | 129 |
Golf Pro: Doug DeSive | Course Superintendent: James David Curlee, CGCS | Manager: Kelly Schmidt, Ph.D.,CCM |
Note: The info we have is generally valid, however, occasionally there will be inaccuracies. Should you spot something that ought to be updated, please inform us immediately.
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Two-Minute Review: The Wrestler (2008)
I have little in common with Randy "the Ram" Robinson, the wrestler of "The Wrestler." He likes what I don't ('80s hair metal), lives where I haven't (trailer park) does what I could never do (wrestles). And yet I wholly identified with him. Maybe it's because we've both reached a certain age. Maybe it's that sense of hitting a dead end and being unable to see a way out or back. There's a scene where, out of necessity, Randy moves from doing manual labor in the back of a grocery store to working with the public in the front. You know why he doesn't want to do it. He was once a star, and now he's here, and he doesn't want people to know he's here. I even identified with that. It reminded me of after high school, after college, the jobs you didn't want, the things you didn't want to have to wear when you had the jobs you didn't want. It reminded me of this thought: Please don't let anyone see me here. Most of the jobs our economy creates — when it was creating jobs — are those kinds of jobs. Please don't let anyone see me here.
"The Wrestler" is a hard movie to watch, and, despite the above, and despite some pretty gruesome wrestling scenes, the toughest part, for me, was watching how needy Randy becomes once wrestling is taken away from him. "The Wrestler" is a perfectly titled movie because that's who Randy is, and once he's told he can't be that he doesn't know how to live. In life you struggle to find a thing you like and do well, and hope you get paid for it, and for a time Randy the Ram was paid well (in money, in fame, in everything that goes with it) for doing the thing he liked and did well. Then he wasn't. Falls happen. We don't know why his did, it just did.
Some have compared this movie with "Rocky" — both are about gentle giants, working class bruisers, who make their living in the ring — but the comparisons end there. "Rocky" is about a guy who never made it but is given a chance. "The Wrestler" is about a guy who did make it…and then has everything taken away. That's what the movie is about. What do you do when everything is taken away? What do you do when you reach the dead end?
There's an answer.
Tags: Movie Reviews, The Wrestler, Mickey Rourke
Posted at 07:36 AM on Tue. Jan 27, 2009 in category Movie Reviews - 2000sCOMMENTS
Twitter: @ErikLundegaard
Tweets by @ErikLundegaardMy Top 25 Movies of 2014
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Bow-Chicka Bow-Wow is Tucker's catch phrase. First coined in Episode 58, he frequently uses it to express his sexual fantasies, mainly about Tex. As the season progresses, he uses it again and again, much to the annoyance of Church. Later in the series, he has seemed to have stopped using it as much.
The Blood Gulch ChroniclesEdit
- Episode 58: 4 times said normally. Many variations as well: "Bow-Chicka-Bow-Whoa" said by Tucker when Tex aimed a gun at his head for making a joke; "Bow-Chicka-Chicka-Bow-Wow-Chicka-Chicka-Bow-Bow-Chicka-Chicka-Bow-Boooooww!"
- Episode 59: "Get behind me and stay tight" "Bow-Chicka-Bow-Wow"
- Episode 92: "I just wanted to say, I got a hardline Tex can use. Bow chicka bow wow."
- Epsiode 94: "Bow-Chicka-Honk-Honk." Said by Junior.
- Episode 99: "Hey-Chicka-Bump-Bump!" - Caboose's version.
- Episode 100: Alternate endings to Episode 100: "Bow-Chika-Bow-Owww!" Tucker was in the middle of one until he was killed by Grif in one of the non-canon endings to Episode 100. Another one: "Sorry, that was my fault. Some guy kept screaming into the mic." "BOW-CHICKA-BOW-WOW!" "Dude, Shut up!" "See?" "BOW-CHICKA-BOW-WOW" "That's it, I'm muting him."
- Reconstruction Chapter 17: "Yeah, slip it to 'em! Bow-Chicka-Bow-Bow."
- Called Up: "Okay, well maybe I am that easy, Bow-Chicka-Bow-Wow. See, now that's a setup."
- For Those of You Just Joining Us...: "That's a lotta graves. Lotta holes to fill. Bow-Chicka-Bow-Wow.
Season 10Edit
- What's the "I" Stand For?: 4 Times said, but in all those times he is either interrupted by Epsilon or Carolina, preventing him from completing the phrase.
- "Dude, he said hard on. Bow chicka-"
- "I've got about five positions in mind for her. Bow chicka-"
- "BOW CHICKA BOW- (Carolina fires at him) -WHOA! SAME TEAM, SAME TEAM!"
- "I'll fill her in. Bow chicka-"
- Reckless: When Doc is giving a pep talk to the Reds and Blues about all the good things that they've been through, he says that Tucker learned to use his sword 'like a pro'. Tucker responds with a confused 'Bow chicka bow wow?'
Season 11Edit
- A Real Fixer Upper: When Tucker tries to flirt with a pilot.
- S.O.S.: To Grif: "Now thats something I can get behind. Bow-chicka-bow- WAIT! NO NO NO NO NO!"
Season 12Edit
- Catch Up, No Mustard: When Tucker tries to make a perverted joke about Emily Grey, but is cut off by Caboose.
- "Bow-Chicka-Bow-Wurrghhhhh..." - Tucker was pretending to be a zombie in Planning to Fail.
- While discussing emoticons with Simmons in Match Breaking.
- "Bow-Chicka-Buy-Stuff" - said by Tucker on the Rooster Teeth Store Specials Page.
- In the Red vs. Blue: Season 9 Soundtrack, Tucker has a whole song based around it.
- In a deleted scene from Season 9, Sister says "Who do you have to blow to get a speaking part around here?", where Junior replies "Bow-Chicka-Honk-Honk."
- In the Season 5 outtakes, a portion includes Caboose trying out new variations for Tucker's phrase, which include:
- "Hey-Chicka-Arf-Arf!"
- "Bum-Chicka-Bow-Bow!"
- "Bumm-Chicka-Arf-Arf!"
- "Bump-Diddly-Bump-Bump!"
- "Jay-Chicka-Bump-Fra-Fer-Nrack-Bak-Bak-???"


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Moore stays on board for gold
It should have been an intimidating situation, but it wasn't for 7-year-old Paul Moore.
Paul has no fear.
Age just a small hurdle for cross country racer
In an event filled with young athletes, Barney Sword knows he's an exception. At 74, Sword, of Columbia, was the oldest competitor in the Show-Me State Games Cross Country race. However, it's a fact that doesn't bother him.
"With running you have to realize you're competing against yourself, not the people around you," he said. "I can't control how fast or slow someone else is, I just have to satisfy myself."
Big Dogs race with the pack during cycling competition
A couple of canines were among the 96 competitors in the Show-Me State Games cycling race Saturday morning.
Romel "Lucky Dog" Quinones, 50, placed second in his age division and Bill "Daddy Dog" Earp, 62, won his age division.
New stadium on Mavs' wish list
The Mid-Missouri Mavericks and city officials have had preliminary discussions about the possibility of a new stadium for the club, now in its third year in Columbia.
"When I traveled to the Gateway park in the Frontier League, I thought it would be nice for the Mavericks and the good people of Columbia to have a fan-friendly ballpark," Mavericks' co-owner and president Gary Wendt said.
Mavericks win in ninth
The Mid-Missouri Mavericks beat the Richmond Roosters 6-4 on Thursday night in the second game of a three game series at McBride Stadium in Richmond, Ind.
Getting kids active
Columbia children will have the chance to shape up and have fun next week.
An Active Kids Club session will be held from 8:30 a.m. to noon Monday through Thursday at Cosmo-Bethel Park. For $25 per day, children entering third, fourth and fifth grades can play soccer, basketball, street hockey, kickball, relay games, flag football, and dodgeball.
Another Tiger golfer qualifies for US Amateur
Shawn Jasper became the second Tiger golfer to qualify for the 2005 U.S. Amateur when he tied for second on Wednesday at the St. Louis sectional qualifier. Jasper had a two-round score of 143. Chris Mabry was a medalist at the Lawrence, Kan., sectional qualifier on July 25.
MU self-audit details concerns
Concerns about improper gifts to college athletes prompted MU to repeatedly warn local car dealers, restaurants, health clubs, hotels and other businesses to keep their distance, an internal audit shows.
A draft report to the NCAA obtained under Missouri's public records law shows no evidence of such gifts, but the athletics department issued warnings as recently as March after at least three previous notices since 2000.
Back on course
Fred Garver bent down and rubbed his hand in the dirt on the second tee of his private disc golf course on Wednesday afternoon.
He lined up his shot, aiming across the calm surface of a lake to a metal basket in the shadow of a massive tree.
Golf tournament part of memorial
When John Thomas died of cancer in February, no one who knew him expected a golf tournament would be held in his name less than six months later.
"He probably never played golf in his life," said Price Nichols, a friend of Thomas.
Mavericks routed, drop fifth straight
The Mid-Missouri Mavericks lost their fifth straight, falling 15-3 to the Richmond Rascals on Wednesday night at McBride Stadium in Richmond Ind., in the first game of a three game series.
The Mavericks (21-41) scored two runs off a third-inning one-out home run by third baseman Brent Metheny, who went 2-for-3.
Tigers picked to finish second in big twelve
Big 12 Conference coaches picked the Tigers to finish second in the conference behind Nebraska. The Tigers, who finished the 2004 season 20-9 overall and 14-6 in the conference, return six of last year's seven starters. Two Mizzou players earned spots on the Preseason All-Big 12 Team. Senior Lindsey Hunter was selected to the team for the second year in a row. Hunter has led the conference in assists for the past three seasons. Hunter also earned second-team AVCA All-American honors last season. Junior Jessica Vander Kooi was named to the team for the first time. Vander Kooi had 18 ...
Ozark Off-Road Challenge around the corner
The Ozark Off-Road Challenge triathlon is scheduled for Aug. 28 at Lake of the Ozarks. All proceeds will benefit the American Cancer Society.
Registration fees are $50 per individual, $120 per team. Registration is available online only, at active.com. The last day to register is Aug. 26.
Carpenter aces test at Busch
ST. LOUIS — To Chris Carpenter, facing Dontrelle Willis was not a Cy Young preview. It was just another stingy outing.
Carpenter is coming out on top against all of the National League's aces. He threw a three-hitter Tuesday night to become the major leagues' first 16-game winner in a 3-1 victory over Willis and the Florida Marlins.
Chiefs' defense feeling pressure
RIVER FALLS, Wis. — The hard-driving and perpetually sleep-deprived defensive coordinator of the Kansas City Chiefs trudged slowly up the long flight of stairs toward the lunchroom.
Sorry, Gunther Cunningham said through heavy eyelids, no time now to chat. Maybe later. Too many things to think about. Too much to do.
Missouri players honored
MU senior safety Jason Simpson was named a preseason third-team All-American by CollegeSportsReports.com on Monday.
Simpson, an MU football co-captain, finished his junior season in 2004 with career-best performances in tackles (98), tackles for a loss (15), forced fumbles (two), passes broken up (six), quarterback hurries (three), and interceptions (one).
Charitable advice
Professional golfers from across the country gathered Monday at the Country Club of Missouri to play golf to benefit a local organization.
The Rainbow House Golf Classic, in its 15th year, has been the undertaking of PGA instructor and former MU golfer Stan Utley.
Finally, some rest for weary Mavs
The Mavericks have gone 19 days without a day off, not counting that rainout in Rockford last week.
They wouldn't have complained if it came even a day sooner.
Palmeiro violates steroid policy
NEW YORK — Rafael Palmeiro poked his finger in the air for emphasis and raised his voice with all the indignation of a man falsely accused.
"I have never used steroids. Period," he told a congressional panel in March.
Harris boosts Florida
ST. LOUIS — Career pinch-hit leader Lenny Harris had a three-run go-ahead double in the sixth inning, helping the Florida Marlins beat the St. Louis Cardinals 6-5 on Monday night.
Mike Lowell hit his second road home run of the season and had three RBIs for the Marlins, who have won five of six. Juan Encarnacion had three hits and scored twice.


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Contact Information
Tnm Holdings, Llc1560 Sawgrass Corporate Parkway 4th Floor
Sunrise, FL 33323
Other Information
Entity Status: ActiveType of Entity: Limited Liability Company
Entity Creation Date: Oct 20, 2011
Days in Business: 1293 days
Company Description
Tnm Holdings, Llc is located in Sunrise, Florida and is listed as an active Limited Liability Company. Tnm Holdings, Llc was started on Oct 20, 2011 which was 1293 days ago.
Terrence Williams: MgrRegistered Agent
Terrence WilliamsSunrise, FL 33323
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CEOs Paid to Crash
As the portfolios of ordinary shareholders imploded in the second stock-market crash of the 21st century, CEOs looked up from the smoke and ashes and breathed a collective sigh of, "Hey, you know what? It's a buying opportunity."
Only CEOs don't have to buy. They get their crony boards to award them stock options.
More than 90% of the CEOs of companies in the Standard & Poor's 500-stock index loaded up with stocks or options in the grim, uncertain months between October 2008 and September 2009. And the value of this largely free equity has since grown by more than $3 billion, according to an analysis of S&P data published by The Wall Street Journal last week.
The crash allowed our fearless corporate leaders to bet on a scary market at an extremely low price with no risk to themselves. And since the market had crashed so hard, and stock was so cheap, they were able to bag larger numbers of options and shares as well.
Spin the wheel and wherever it lands, the boss is a winner again.
That's because when stocks crash, CEOs get new stocks.
This time, Washington put up taxpayer stimulus money. The Federal Reserve flooded the banking system with trillions of dollars. And interest rates went to zero. Bailing out the economy killed returns on savings accounts, but it pushed the Dow Jones Industrial Average from the 6500s to the 12500s. And the rising tide sure floated CEOs' boats.
How is it that the cost of everything in a corporation has to be constantly justified, except for the cost of the CEO? The market was in the tank. Millions of jobs would be annihilated. Why did CEOs deserve more equity? Retention pay? As if the crash had proved that they were worth retaining?
Stock options are supposed to align CEO pay with shareholder value. But here, CEOs essentially got paid for a market crash and a government-led recovery.
Many S&P 500 CEOs were handsomely rewarded simply because their share prices recovered to 2006 levels. Or not. Take Capital One Financial. Its stock traded in the $80s in 2006, fell to the $8s in 2009, and now trades in the $50s.
CEO Richard D. Fairbank's gain for this performance was $34.5 million. Next time a Capital One commercial asks, "What's in your wallet?" say, "Not that much."
While none of this smacks of illegal activity, it's reminiscent of the stock-option backdating scandal that followed the Internet bust. There's nothing CEOs hate more than underwater stock options. They want no risk (unless it's with other people's money) and extravagant rewards.
To be fair, several executives did more than just ride on the economic bailout wagon. Ford Motor CEO Alan Mulally, for example, has been credited with an impressive turnaround that did not require a federal bailout. His equity gain: $186.8 million. Not bad for a couple years of work, but no doubt supercharged by the crash.
The lesson here is that CEOs get paid for stocks to go up, but often, for stocks to go up, they have to go down. And this perverse economic incentive for a crash only ensures more crashes.


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We're genuinely fired up about all the Shoulder Bags we feature on OpticsPlanet.com. Rest assured, when you shop at OpticsPlanet.com, your experience will be nothing short of excellent. We have put in a lot of hours over the years to offer you an incredible selection of products from tons of brands and serving many different types of customers, from dedicated enthusiasts to the top professionals. But right now we're talking about Shoulder Bags. We carry only the absolute best, and we're an authorized distributor of all of the Shoulder Bags you see here, so you never have to worry about getting less than the very best. When you choose one of the Shoulder Bags we carry, such as one of the , you will get exactly what you're expecting. But we strive to offer you more than simply excellent products and low prices. We know that most of the gear on OpticsPlanet requires some amount of experience to properly evaluate and understand. This is the reason why we've written up a bunch of How-To Guide Articles, and we're writing more every day. Additionally, we employ specialists on hand to help you with all of your questions and provide you with purchasing ideas. When you're looking for top of the line Shoulder Bags, it's a good idea to come here first. We have the options you need, the prices you want and the service you deserve!


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Just for fun, we raided GH staffers' makeup bags, then asked for some quickie analysis from Gail Saltz, M.D., clinical associate professor of psychiatry at New York-Presbyterian Hospital. While reminding us that personalities are too complex for simple 'stick theory, Dr. Saltz spilled this: If you apply your lipstick so that it keeps its original shape or wears down on only one side, you're the cautious type. If you warp it into being flat or concave, you're more of a risk taker. Our staffer tube test, from left to right: Careful, Spontaneous, Easygoing, Orderly, Natural, Relaxed.
What Your Lipstick Says About You
How to Stop That Annoying Rash Between Your Thighs
Because that's never a fun experience.
Can You Really Make Stretch Marks Disappear?
If so, pass us that magic potion.
12 Hair Secrets From 1957 We'd Totally Follow Today
Because good advice never goes out of style.
More From Beauty


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Definitions for jukedʒuk
This page provides all possible meanings and translations of the word juke
Princeton's WordNet
juke, jook, juke joint, jook joint, juke house, jook house(noun)
a small roadside establishment in the southeastern United States where you can eat and drink and dance to music provided by a jukebox
juke, fake(noun)
(football) a deceptive move made by a football player
Webster Dictionary
to bend the neck; to bow or duck the head
the neck of a bird
to perch on anything, as birds do
Origin: [from Scottish jouk to bow.]
"Juke" is a harmonica instrumental recorded by then 22-year-old Chicago bluesman Little Walter Jacobs in 1952. Although Little Walter had been recording sporadically for small Chicago labels over the previous five years, and had appeared on Muddy Waters' records for the Chess label since 1950, Juke was Little Walter's first hit, and it was the most important of his career. Due to the influence of Little Walter on blues harmonica, Juke is now considered a blues harmonica standard.
Translations for juke
From our Multilingual Translation Dictionary
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Tiny Pink Ribbon TributeThe photos on my pages are actual sew outs on real fabricnot digitized images from software.My designs are digitized by hand to minimize jump stitches and color changes.My goal is to give you a pleasing sewing experience.A tribute to those who fight Breast Cancer.
$24.00 Parts of the proceeds will be used in the Relay for Life and other Races for the Cure.
.58 x .89 inches Bonus download. Click for multi format zip. Don't forget to join the yahoo list for lots more goodies in the files section. |


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Broadway Favorites
- Look inside(1)
- Instrument:
Broadway Favorites for Accordion. Accordion. 48 pages. Published by Hal Leonard (HL.490157).
- Climb Ev'ry Mountain
- Getting to Know You
- I Whistle A Happy Tune
- If I Were A Rich Man
- It Might As Well Be Spring
- Matchmaker
- Mr. Wonderful
- No Other Love
- People Will Say We're In Love
- The Sweetest Sounds
- Don't Cry For Me Argentina
- Oh, What A Beautiful Mornin'
- We Kiss In A Shadow
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Disney Songs for Accordion - 2nd Ed... $9.95
Italian Favorites for Accordion wit... $16.95 $10.17
Tango Time! $12.95
Latin Favorites for Accordion $10.99
International Accordion Favorites $19.99
Hungarian Music for Accordion $15.95
Palmer-Hughes Accordion Course - Ea... $6.95
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Accordion Uff Da! Let's Dance $19.99
Broadway Favorites
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{ 3 comments }
Ubuntu Linux
I've build my own lighttpd .deb package and I do not want to upgrade it using the apt-get command. Also, I do not want to upgrade a few more packages such as php5-cgi, httpd and so on. How do I blacklist a package or packages so that when I run apt-get upgrade, it will ignore blacklisted packages and install the rest of updates under Debian or Ubuntu Linux server system?
{ 3 comments }
I would like to install something from source code. The site says that I need to download it from git repository. How do I download a git repository under Debian / Ubuntu Linux?
{ 1 comment }
I've the NetworkManager service is installed and started under Linux desktop. The applet is running. The NetworkManager can display available network hardware and wireless networks. But, I'm unable to add VPN support as the Add tab is greyed out. I need to use both PPTP and Cisco vpn clients. How do I fix this problem under Debian or Ubuntu Linux?
{ 23 comments }
How do I display information from /proc such as memory, Load average, uptime, page activity, context, disk status, interrupts using a shell or perl script?
{ 8 comments }


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I remember back in the day when Duct Tape was used for actually taping things! I'm perfectly fine with it's new job as an artistic medium though!
Head on down past the break to watch Rainbow Dash come to life via duct tape!
Share This!Duct Tape Rainbow Dash Timelapse2012-09-29T22:00:00-07:00SethistoArt|Media|Not-Fanfiction|Comments -
This is probably one of the oddest PMV posts we have had in a while! Based on the title, you can probably guess why that one falls into this category though if you have ever seen the original.
Anyway, have a bit of Southpark, happy Pinkie Pie, and rum.
1.) [PMV] South Park Intro
2.) Pinkie Feels Fantastic
3.) [PMV] My Little Pony: Why's the rum gone!? - Pirates of the Caribbean
Share This!PMV: South Park Intro / Pinkie Feels Fantastic / Why's the Rum Gone?!2012-09-29T21:00:00-07:00SethistoMedia|Not-Fanfiction|PMV|Comments -
Double the animations, double the fun! Or something like that. If that happens to be a trademark by some large company, I take money by Paypal. I've got two animations here for you guys today:
Pega - Custom 3D animation abound! This one's about a pegasus who totally cuts a wave in half. It's as awesome as it sounds.
My Little Senior - Bonus! This one was inspired by the FiM voice actresses.
Find them both after the break!
Share This!Animations: 'Pega' | 'My Little Seniors'2012-09-29T20:00:00-07:00Cereal VelocityAnimation|Not-Fanfiction|Video|Comments -
Last Exit to Ponyville, the radio show we featured earlier this month, is ready to start recording their first October show, and you know what that means: they need call-ins from you guys!
Want to be on the show? Read their blurb below!
Greetings ladies and gentlecolts!
We are preparing for our first October episode on Last exit to Ponyville to record next week and that means... MORE CALL INS!
Our question is: "What is your favorite moment of season 1?"
We will be using a max of 5 minutes for call ins for this show BUT fear not,I will include them in our post credit roll for the show so no matter what (within reason, you'll be on the show!) Our call in number is 817-717-7202 OR you can email us @ email@example.com subject: Ponyville.
Lastly we want to grow our community and interact with you on a daily basis so visit our new facebook page
All new shows will be posted here
Here is a sneak peak at the Ponyville Giftshop as well
Share This!'Last Exit To Ponyville' Update2012-09-29T19:00:00-07:00Cereal VelocityMedia|Not-Fanfiction|Podcast|Comments -
Is Applejack your favorite pony of all time? Do you dream of working long hours on Sweet Apple Acres and taking a break in an apple filled farm house with the apple family while eating various apple products and showering with their apple scented cleaning products? You might want to head on over to Big Lots then and pick up a set of apple scented bath products! That's a lot of soap for just five bucks!
The submitter, Regan, also pointed out that they had a 10 dollar "mane care" set complete with hairclips and a comb.
I bet conventions would be way cooler if these were passed out for free with tickets!
Share This!Smell Like Apples at Big Lots!2012-09-29T18:00:00-07:00SethistoMerchandise|News|Not-Fanfiction|Comments -
You guys just love that writing thing. So much so that Noble Cause needed a bit of time to get it all compiled! It looks like quite a few people hit the 50k mark this year. That's straight up impressive guys! I get tired after just a paragraph.
And because of that, I'll let Noble take over from here. Head on down past the break for a list of entries and his closing speech!
DVD Containing Super Speedy Cider Squeezy 6000 Packaged With Next Year's Brushie Singles
by Cereal VelocityThat was a very long title!
Whatshisgame reports to us that a DVD containing the episode Super Speedy Cider Squeezy 6000 will be packaged with next year's brushable toy packages, one of which was the Crystal Empire Fluttershy we saw earlier this month. The email blurb explains it thusly:
A DVD of The Super Speedy Cider Squeezy 6000 will be coming in four brushable toy packages (one of which is that Crystal Empire Fluttershy we saw at the beginning of this month). The assortment has been listed for pre-order online by Midtown Comics, Comics Infinity, Westfield Comics, Things From Another World, Movie Replicas Direct, and Urban Collector, generally with a release date of January 30, 2013 or a bit later. But the retail price is $83.88, and the lowest any of those sites are selling for right now is $67.10—either it's for whole cases full, or the Flim Flam brothers themselves are behind this!
Share This!DVD Containing Super Speedy Cider Squeezy 6000 Packaged With Next Year's Brushie Singles2012-09-29T16:00:00-07:00Cereal VelocityNot-Fanfiction|Toys|Comments -
[Adventure] [Shipping] "If you liked Within and Without, give this story your immediate attention. Cloudy Skies is deceptively adept at writing adventure fics as he is with his normal subject matter, and I think even new readers of his will enjoy his latest offering. The ways he portrays our favorite pastel ponies are as convincing as they are enjoyable, and I invite you to get lost in his world to see what you find." -- Pre-reader \--,
Author: Cloudy Skies
Description: Applejack had long since taken the Hearth's Warming Eve story for fact. When she and Fluttershy find themselves in an untamed wilderness, they'll learn that not all history is preserved. In their struggle to find their way home, the two will unearth secrets unknown to any living being, pony or otherwise.
Lost and Found (New Part 31+31+Epilogue!)
Half a world away, the others have problems of their own. As Rainbow Dash struggles to discover exactly what she is to her oldest friend, Twilight must face the stunning truth about her long-time mentor.
In the end, what is lost, and what is found?
Additional Tags: Long-distance Shipping, FlutterDash, Historyat 2:30 PM
Labels: Adventure, Author: Cloudy Skies, Celestia, Complete, Everypony, Luna, Shipping, Star-Needed, StoryShare This!Story: Lost And Found (Update Part Complete!)2012-09-29T14:30:00-07:00Cereal VelocityAdventure|Author: Cloudy Skies|Celestia|Complete|Everypony|Luna|Shipping|Star-Needed|Story|Comments -
We are a bit late on this one, but for that wanted to catch the Fighting is Magic tournament, the delays are finally over on it! Head on over to the Mane6 website to check it out, or hit the stream up directly.
And if you want a complete list of moves, they released a post on it here.Share This!Fighting is Magic Tourney Begins!2012-09-29T13:55:00-07:00SethistoConvention|Game|Not-Fanfiction|Comments -
Season 3? Pff! We have so much fan animation on the way we might as well just run our own series at this point! Silly Filly Studios has released a trailer for their upcoming "snowdrop" with the following synopsis:
Wonderfully written by Meredith Sims (https://www.youtube.com/user/Emichwan88), Snowdrop is a heartwarming tale that takes you back in time to after Discord's reign, when Equestria was still young. It follows a young filly who makes a discovery that offers Cloudsdale--and Equestria--a gift, one that today many take for granted.
Yeah, I can't wait. Check the trailer out after the break.
Share This!Animation Trailer: Snowdrop2012-09-29T13:14:00-07:00SethistoAnimation|Media|Not-Fanfiction|Comments -
There's been a large number of people coming into the door at Canterlot Gardens trying to get into the convention as walk ins. Unfortunately, the convention is sold out.
This applies to both Saturday and Sunday passes. If you've been considering attending, you will unfortunately have to wait another year. Please take this under advisement. Go see a movie. Eat lunch somewhere nice. Just hang out with friends and try to get a head start on salvaging the day/weekend. And remember, the only way to guarantee yourself a place in any convention is to pre-register.
This has been a public service announcement from your friends at Equestria Daily. EqD: The only place for pony news where all the staff are obsessed with whales. I'm tired. Peace out.Share This!Canterlot Gardens Sold Out2012-09-29T12:10:00-07:00PhoeConvention|News|Not-Fanfiction|Comments -
Image Source: Rolling Stone
I'm sure you are all curious about what exactly Andrew W.K.'s goals were at a pony convention. He may love Pinkie Pie almost too much, but is he actually into this whole Friendship is Magic thing? Head on over to their page to check out what they thought about it, and for a few quotes from the professional partier himself!
And after the break, you can find a recording of the full panel for those of you that missed the livestream.
Share This!Rolling Stone Reports on Andrew WK at Canterlot Gardens + Panel Video2012-09-29T12:09:00-07:00SethistoMedia|Not-Fanfiction|Comments -
The two behind Friendship is Witchcraft has done a parody of "At the Gala" to celebrate Canterlot Gardens.
It's actually pretty catchy! Check it out below the break.
Share This!"The Convention" - Parody2012-09-29T12:05:00-07:00SethistoMedia|Music|Not-Fanfiction|Comments -
Caped mares, Pokemons, Luna polls, and Pinkie Pie being even more random than usual. It's comic time!
Share This!Comic: The Hero / Maybe Catch'em / I Rigged It / That YT Song2012-09-29T11:00:00-07:00SethistoComic|Not-Fanfiction|Comments -
I'd make Luna the official mascot of Instrumental posts, but she isn't included in this one for whatever reason! Have some music.
1.) My Cadence (Orchestral Arrangement)
2.) Element7 - CRUSH. KILL. DESTROY. HUG. | Sweetie Bot Tribute Song (Samples / Electronic)
3.) Abandoned (By TheDashDub) (Soft Electronic/Strings)
Is that... Katamari Dapony? Can they do that? Can they roll ponies up into a ball and turn it into a planet?
Welovefine has released a bunch of new designs over in their pony section. These guys seem to be dropping them at an almost weekly rate now days. Keep growing pony fandom!
And in other news, it looks like they have run out of blindbags for their free pony promo. I'm sure we will see them replaced by something soon though!
Anyway, check out the rest of the designs after the break.
Share This!More Welovefine Shirts with Crazy References2012-09-29T09:00:00-07:00SethistoMerchandise|News|Not-Fanfiction|Comments -
What do we do when Sweetie Belle's voice actor releases lets plays of her shenanigans in Minecraft? We animate it of course! It's super simple, but also completely ridiculous. Check it out below!
Share This!Sweetie Belle Plays Minecraft2012-09-29T02:28:00-07:00SethistoAnimation|Media|Not-Fanfiction|Comments -
Roundup time! It's not the longest ever, but it does have cake. You like cake right?
And thanks to the guys from Dusk's Dawn for the new EQD header! I guess you guys were sick of Jet Set Radio!
Share This!Nightly Roundup #4522012-09-29T01:38:00-07:00SethistoCommunity|News|Nightly Roundup|Not-Fanfiction|Comments
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See the latest Boehringer Ingelheim news releases. To quickly find all news releases on a specific topic, please use the fulltext search.
New bottle for Ingelvac MycoFLEX® simplifies mixing with Ingelvac CircoFLEX®
Large scale registry shows atrial fibrillation management is suboptimal and unequal around the world
Key results from new tiotropium studies in COPD and asthmato be presented at ERS 2012
Clinical experience with Pradaxa® crosses one million patient-years of treatment
Boehringer Ingelheim achieves further growth in first half of 2012 – difficult business environment expected for the second half of the year
Boehringer Ingelheim Biopharmaceuticals announces manufacturing agreement with Servier
Jentadueto® (linagliptin/metformin hydrochloride) tablets receive approval for the treatment of adults with Type 2 Diabetes in Europe
Boehringer Ingelheim and Funxional Therapeutics announce acquisition of Funxional's FX125L and the somatotaxin portfolio to treat inflammation
Ilka Diester wins Boehringer Ingelheim's FENS Award 2012 for Exceptional Research in Neuroscience
Boehringer Ingelheim pursuing health care innovation – new collaboration with Healthrageous, Inc on a digital diabetes self-management program
Boehringer Ingelheim Establishes Translational Research Collaboration with Harvard University in Areas of Unmet Medical Need
Boehringer Ingelheim announces changes to Board of Managing Directors: Joachim Hasenmaier to lead new Board Division Consumer Healthcare and Animal Health
New publication in The Lancet: Two-year study in over 1,500 patients compares Trajenta® (linagliptin) to the commonly prescribed sulphonylurea glimepiride
No significant difference in the risk of Acute Coronary Syndrome (including Myocardial Infarction) seen with Pradaxa® (dabigatran etexilate) compared to enoxaparin for VTE prevention after orthopaedic surgery
First study to evaluate alternative to warfarin for mechanical heart valve patients launched with Pradaxa® (dabigatran etexilate)
AF patients who require surgery benefit from a shorter treatment interruption on dabigatran etexilate (Pradaxa®) compared to warfarin
Boehringer Ingelheim BioXcellence:Distinctive brand for the biopharmaceutical contract manufacturing business
Boehringer Ingelheim once again certified as a family-friendly company


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moose booties
- the story
Moose Crossing
Keep your little one cozy with these charming woodland moose booties, handcrafted from eco-friendly felted wool by the Kyrgyz artisans of Kork, Fiber Art Group.
These playful booties are part of our continental collection, featuring charming handcrafted animals to represent each continent. Choose from a menagerie of pandas, giraffes, koalas, penguins, deer, and parrots, or collect them all so your wee one can take his first steps toward world traveler status. Handmade in Kyrgyzstan.
Due to the handmade nature of this item, each is unique and will vary.
- details
- Item ID
- 24209
- Made from
- sheep wool
- Measurements
- 4.5" L x 2.75" W; 0-12 months
- Notes
- Clean with damp cloth, air dry.
You might also like…
Gator Booties $25.00 -
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Baby Guppy Slippers $34.00 -
Parrot Booties $25.00 -
Penguin Booties $25.00 -
Bunny Felt Baby Slippers $32.00 -
Giraffe Booties $25.00 -
Whale Booties $25.00 -
Toddler Shark Slippers $38.00 -
Baby Puppy Slippers $34.00


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(978) 831-3924
Painters & Painting Contractors
Are you looking for an expert painter for interior painting, sheet rock repair, or paper hanging services? J & J Resnick Paint and Paper Hanging offers high quality wall papering services & paper hanging ... more
Interior, Exterior, Specialty Painting, Wall Papering
© 2015 Local Corporation - US Patent 7,231,405
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I am into music, crafting, organizing events, hanging out with friends, cooking, traveling around the world (been lucky to travel a lot thus far), and am sailing the Bay as of recently.
I am said to be open minded, respectful and responsible, (trying to be) funny, keen on non-politically correct humor. You shall see for yourself!


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Hootsuite Media, Inc. Hootsuite is the world's most widely used social media relationship platform. More than 10 million users, including 744 of the Fortune 1000 companies, trust Hootsuite to manage their social media... read more
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MusXpand MusXpand is a social network and music distribution site for independent artists and music fans, founded in March 2011 in Vancouver, BC, Canada. read more
Lovesocial Lovesocial was founded in 2009 with a vision of creating authentic and creative communication strategies through the channels of social media. With a motto of, "keep it simple, find the value and... read more
SocialFollows Social Follows is an all in one Twitter Marketing and Management Tool. We help users define, target and engage their customers, users and followers alike. read more
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Marygrove Alert: Due to inclement weather, the campus will be closed for the remainder of Tuesday, March 3rd. We will reopen tomorrow unles
The Faculty Technology Center is where Educational Technology Services staff assist faculty in successfully integrating technology to enhance the teaching and learning process. This is achieved by offering web-based course materials, digital media services, technology-enhanced classrooms, open-access computer labs, group workshops, one-on-one consultations, support documentation, and technology-related special events.
Call 313.927.1846 for assistance.
How can we help? | Resources & Guides |
Faculty Technology Center: Your personal instruction lab Request a technology training session for your students TurningPoint, an audience response system Instructional Technology Survey: how can we better meet your needs? |
Blackboard resources for faculty New Media Consortium publication that identifies and describes emerging technologies likely to have an impact on teaching, learning, or creative inquiry on college and university campuses within the next five years. Online Course Development forms |
Weebly – Create your own website … FREE Marygrove ETS News Scenario 1: You're an avid gardener/quilter/cake decorator/craftsperson and want to... Read more... |
2015 Winter Semester STICC Word 2010 Workshops Marygrove ETS News Word 2010 – 1
Tues., Jan 20 10 a.m. – 12:30... Read more... |
Technology Assistant's Corner Marygrove ETS News Technology Assistants are available in the STICC and the Library... Read more... |
Rules in Microsoft Outlook Marygrove ETS News A rule is an action that is done automatically to... Read more... |
Student Tech Talk: Epsilen ePortfolios Marygrove ETS News In recent years, electronic portfolios have gone from being just... Read more... |
Exciting Things are Happening in ETS! Marygrove ETS News Fall 2014 ushered in some very neat changes to the... Read more... |
Marygrove Alert: Due to inclement weather, the campus will be closed for the remainder of Tuesday, March 3rd. We will reopen tomorrow unles
RT @BLMDetroit: #BLMDetroit Are you coming to" #Detroit to #Ferguson" 630PM Tonight @MGCollege ? Live tweet using #D2Ferguson http://t.co/J…
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Happy #MartinLutherKing Day from Marygrove College. http://t.co/AUm50LySKV
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recipe reviews for:
"Delicious white bean chili. Cha Cha says: 'It's kinda spicy, so watch out!' Substitute mild green chiles for the jalapenos if you're scared! Use more chicken and cheese as desired."
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This zesty white-bean chili packs some heat!
A flavorful chili that's a little lighter with less fat.
See how to make a simple and delicious white bean chili.


text: Jobs Companies & Reviews Companies Salaries Interviews Hiring? Post a Job RPG Programmer Salaries in Fairfield, CA 1 Salaries Change location: US - All Cities – San Francisco, CA Area — Fairfield, CA Sort: Popular Most Reports Salary Salaries in $ (USD) Average Min Max RPG Programmer Copart (2 Copart Fairfield Salaries) $97,809 $89k $107k $97,809 $89k $107k Embed this report Anonymized Range [?] If we only have one or two salaries posted for at , showing that salary information may risk employee anonymity. So in that case we generate an anonymous salary range by adding and subtracting a small percentage from the posted salary. The small percentage difference offers additional anonymity while still minimizing the difference between the range and the employee's actual salary. Salaries > RPG Programmer > Fairfield