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Results 51 - 100 of 2589 | ||
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Voora Deepak D Institute for Genome Sciences and Policy, Duke University, 905 S. Lasalle Dr., DUMC Box 3445, Durham, NC 27710, USA. - - 2012
To develop an integrated metric of non-COX-1-dependent platelet function (NCDPF) to measure the temporal response to aspirin in healthy volunteers and diabetics. NCDPF on aspirin demonstrates wide variability, despite suppression of COX-1. Although a variety of NCDPF assays are available, no standard exists and their reproducibility is not established. We ...
Comstock Timothy L TL Global Pharmaceuticals, Bausch Lomb, Inc., Rochester, NY 14609, USA. - - 2012
Loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension (LE/T) is indicated for steroid-responsive inflammatory ocular conditions where superficial bacterial ocular infection or a risk of bacterial ocular infection exists. LE/T was shown to be safe in healthy volunteers and patients aged 18 years and older with minimal effect on intraocular ...
Morani Aashish S AS School of Biological Science, Victoria University of Wellington, Wellington, New - - 2012
Kappa opioid receptor (KOPr) activation antagonizes many cocaine-related behaviors but adverse side-effects such as sedation, dysphoria, and depression limit their therapeutic use. Recently, salvinorin A (Sal A), a naturally occurring KOPr agonist, has been shown to attenuate cocaine-induced drug seeking in a model of relapse in rats. The present study ...
Lee Janet S JS Pulmonary, Allergy, and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, - - 2012
Red blood cell (RBC) transfusion is associated with alterations in systemic concentrations of IL-8/CXCL8 functional homologs in a murine model. Whether RBC transfusion alters systemic neutrophil chemokine concentrations in individuals sustaining traumatic injury is not known. We conducted a retrospective, single-center study of severely injured trauma patients presenting within 12 ...
Jungsuwadee Paiboon P Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, - - 2012
Doxorubicin-induced acute cardiotoxicity is associated with the Gly671Val (G671V; rs45511401) variant of multidrug resistance-associated protein 1 (MRP1). Doxorubicin redox cycling causes lipid peroxidation and generation of the reactive electrophile, 4-hydroxy-2-trans-nonenal (HNE). Glutathione forms conjugates with HNE, yielding an MRP1 substrate, GS-HNE, whose intracellular accumulation can cause toxicity. We established stable ...
Wu Chunxiao C Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, BC, - - 2012
Next-generation sequencing is making sequence-based molecular pathology and personalized oncology viable. We selected an individual initially diagnosed with conventional but aggressive prostate adenocarcinoma and sequenced the genome and transcriptome from primary and metastatic tissues collected prior to hormone therapy. The histology-pathology and copy number profiles were remarkably homogeneous, yet it ...
Three different strategies to obtain porous calcium phosphate cements: comparison of performance ...
Klijn Reinoud J - - 2012
Preprosthetic surgery has become a routine procedure to obtain sufficient bone quantity and quality for dental implant installation in patients with an initial inadequate bone volume. Although autologous bone onlay or inlay grafting is still the preferred bone augmentation technique, a broad range of synthetic bone substitutes have been developed, ...
Hite Kristopher C - - 2012
Methyl CpG binding protein 2 (MeCP2) is a canonical intrinsically disordered protein (IDP), that is, it lacks stable secondary structure throughout its entire polypeptide chain. Because IDPs often have the propensity to become locally ordered, we tested whether full-length MeCP2 and its constituent domains would gain secondary structure in 2,2,2-trifluoroethanol ...
Maynard Robert L RL Southcott, Parkham Ash, Bideford, Devon, UK. - - 2013
Whilst alveolar macrophages normally clear micron-sized particles from the respiratory units, nanoparticles might by-pass this mechanism and interact with alveolar epithelium. This letter discusses the possible role of alveolar epithelial type 1 cells in uptake and retention of nanoparticles within the alveolar septum. Accelerated apoptosis of nanoparticle-laden type 1 cells ...
Biswas Tapan T Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, - - 2012
Novel antibiotics are needed to overcome the challenge of continually evolving bacterial resistance. This has led to a renewed interest in mechanistic studies of once popular antibiotics like chloramphenicol (CAM). Chloramphenicol acetyltransferases (CATs) are enzymes that covalently modify CAM, rendering it inactive against its target, the ribosome, and thereby causing ...
Nolan R P - - 2012
A central hypothesis of the cholinergic anti-inflammatory reflex model is that innate immune activity is inhibited by the efferent vagus. We evaluated whether changes in markers of tonic or reflex vagal heart rate modulation following behavioural intervention were associated inversely with changes in high-sensitivity C-reactive protein (hsCRP) or interleukin-6 (IL-6). ...
Fuentes Fajardo Karin V - - 2012
Disease gene discovery has been transformed by affordable sequencing of exomes and genomes. Identification of disease-causing mutations requires sifting through a large number of sequence variants. A subset of the variants are unlikely to be good candidates for disease causation based on one or more of the following criteria: (1) ...
Dingari Narahara Chari - - 2012
Despite the intrinsic elemental analysis capability and lack of sample preparation requirements, laser-induced breakdown spectroscopy (LIBS) has not been extensively used for real-world applications, e.g., quality assurance and process monitoring. Specifically, variability in sample, system, and experimental parameters in LIBS studies present a substantive hurdle for robust classification, even when ...
Tulchinsky Mark - - 2012
Hepatobiliary scintigraphy is a mature imaging technique for evaluation of patients with acute cholecystitis (AC). It is effective in calculous and acalculous forms of AC. The test is used in contemporary medical practice as the arbiter when the findings from screening abdominal ultrasound do not fit a clinical picture. It ...
Bennink Roelof J - - 2012
Liver function is a broad term, as the organ participates in a multitude of different physiological and biochemical processes, including metabolic, synthetic, and detoxifying functions. However, it is the function of the hepatocyte that is central to sustaining normal life and dealing with disease states. When the liver begins to ...
Fusar-Poli Paolo - - 2012
Striatal dopamine transporter abnormalities are thought to underlie the pathophysiology and psychostimulant treatment of attention deficit hyperactivity disorder (ADHD). However, individual studies using single photon emission tomography (SPECT) or positron emission tomography (PET) have yielded inconsistent results, i.e., both high and low striatal dopamine transporter levels. Nine SPECT and PET ...
Naccarati A - - 2012
A functionally normal TP53 is essential to protect organisms from developing cancer. Somatic mutations in the gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent ...
Maurer Alan H - - 2012
For many years, gastric emptying (GE) studies were performed using various local protocols and different radiolabeled meals. This lack of standardization and normal values made the test results unreliable and difficult to compare from one site to another. A recent consensus has been published that now provides guidance and standardization ...
Hlavata I - - 2012
Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited by the inter-individual variability in drug response and the development of cancer cell resistance. ATP-binding cassette (ABC) transporters play a crucial role ...
Landi Debora - - 2012
Over 2000 microRNA (miRNA) sequences from different species have been submitted to the miRBase, the central online repository for miRNAs, making a total of 5071 miRNA loci, expressing 5922 distinct mature miRNA sequences. In this review, we have addressed the importance of the genetic variations in humans affecting miRNAs, their ...
Ziessman Harvey A - - 2012
Sincalide cholescintigraphy was first reported to have clinical utility in 1980. Since then, many publications have found that a reduced gallbladder ejection fraction (GBEF) can confirm the clinical diagnosis of acalculous chronic gallbladder disease and predict symptomatic relief with cholecystectomy. However, some publications had not found the test clinically predictive. ...
de Miranda Noel F C C - - 2012
Two forms of genomic instability can be distinguished in colorectal cancer (CRC) tumourigenesis. One is characterised by pronounced chromosomal instability (CIN), while the other relates to alterations produced at the nucleotide level that preferentially target microsatellite sequences. Tumours developing under the latter form of genomic instability possess a microsatellite instability-high ...
Huhn Stefanie - - 2012
Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity ...
van Wezel Tom - - 2012
Inherited predisposition plays a role in 10-30% of colorectal cancer (CRC) cases. Of the large families with a clearly positive family history of CRC, ∼40% is not affected by known CRC syndromes. The existence of families with unexplained forms of inherited CRC-familial CRC-suggests the presence of still unknown high- or ...
Parkman Henry P - - 2012
Gastrointestinal (GI) motility disorders are common and cause either delayed or accelerated transit through the stomach, small intestine, or colon. Assessment of GI transit times can provide direct measurements and diagnostic information to help explain the cause of symptoms and help plan therapy. Several diagnostic tests are available. Gastric emptying ...
Slyskova Jana - - 2012
Alteration of DNA integrity is a potential cause of cancer and it is assumed that reduced DNA repair capacity and accumulation of DNA damage may represent intermediate markers in carcinogenesis. In this case-control study, DNA damage and nucleotide excision repair capacity (NER-DRC) were assessed in association with sporadic colorectal cancer ...
Pardini Barbara - - 2012
Colorectal cancer (CRC) is one of the most common cancers worldwide with a peak of incidence in industrialised countries. It is a complex disease related to environmental and genetic risk factors. Low-penetrance genetic variations contribute significantly to sporadic and familial form of CRC. Genome-wide association studies (GWAS) have uncovered numerous ...
Castellví-Bel Sergi - - 2012
The EPICOLON consortium was initiated in 1999 by the Gastrointestinal Oncology Group of the Spanish Gastroenterology Association. It recruited consecutive, unselected, population-based colorectal cancer (CRC) cases and control subjects matched by age and gender without personal or familial history of cancer all over Spain with the main goal of gaining ...
Méplan Catherine - - 2012
Colorectal cancer (CRC) is a major cause of mortality throughout the world and risk of CRC is known to be modulated by nutritional factors. Low intake of the micronutrient selenium (Se) has been implicated as a risk factor in CRC, and in this article we describe the biochemical functions of ...
Simão Roberto - - 2012
Resistance training (RT) is now an integral component of a well rounded exercise programme. For a correct training prescription, it is of the utmost importance to understand the interaction among training variables, such as the load, volume, rest interval between sets and exercises, frequency of sessions, exercise modality, repetition velocity ...
Varga Elisabeth - - 2012
A fast, easy-to-handle and cost-effective analytical method for 11 mycotoxins currently regulated in maize and other cereal-based food products in Europe was developed and validated for maize. The method is based on two extraction steps using different acidified acetonitrile–water mixtures. Separation is achieved using ultrahigh-performance liquid chromatography (UHPLC) by a ...
Bauer Maria - - 2012
Whether decreasing the local anesthetic concentration during a continuous femoral nerve block results in less quadriceps weakness remains unknown. Preoperatively, bilateral femoral perineural catheters were inserted in subjects undergoing bilateral knee arthroplasty (n = 36) at a single clinical center. Postoperatively, right-sided catheters were randomly assigned to receive perineural ropivacaine ...
Crous-Bou M - - 2012
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Epidemiological risk factors for CRC included dietary fat intake; consequently, the role of genes in the fatty acid biosynthesis and metabolism pathways is of particular interest. Moreover, hyperlipidaemia has been associated with different type of cancer and serum lipid ...
Houlston Richard S RS Division of Genetics and Epidemiology, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. - - 2012
Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying ...
Tomlinson Ian P M IP Molecular and Population Genetics Laboratory and Oxford NIHR Comprehensive Biomedical Research Centre, Nuffield Department of Clinical Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. - - 2012
Despite their prime candidate status, polymorphisms near genes involved in DNA repair or in other functions related to genome stability have been conspicuously under-represented in the significant associations reported from genome-wide association studies (GWAS) of cancer susceptibility. In this study, we assessed a set of single-nucleotide polymorphisms (SNPs) near 157 ...
Turnbull Charlotte L CL Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, - - 2012
APC is a key 'gatekeeper' gene in colorectal tumorigenesis. The high frequency of APC defects observed in colorectal cancer tissue is the result of selective growth advantage of cells with loss-of-function mutations at that locus. However, mutations may also arise due to inherent sequence instability. Defective DNA mismatch repair (MMR) ...
Kline Richard P RP Department of Anesthesiology, New York University Langone Medical Center, New York, New York 10016, USA. - - 2012
Structural magnetic resonance imaging is used to longitudinally monitor the progression of Alzheimer disease from its presymptomatic to symptomatic phases. Using magnetic resonance imaging data from the Alzheimer's Disease Neuroimaging Initiative, we tested the hypothesis that surgery would impact brain parameters associated with progression of dementia. Brain images from the ...
Machado Fabiana S FS Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, - - 2012
Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and ...
Baron David M DM Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114-2696, - - 2012
During extended storage, erythrocytes undergo functional changes. These changes reduce the viability of erythrocytes leading to release of oxyhemoglobin, a potent scavenger of nitric oxide. We hypothesized that transfusion of ovine packed erythrocytes (PRBC) stored for prolonged periods would induce pulmonary vasoconstriction in lambs, and that reduced vascular nitric oxide ...
Szarka Lawrence A LA Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, - - 2012
Transit assessment of the small intestine and colon is relevant in the study of physiology, pathophysiology, and pharmacodynamics, and there is increasing use of small-bowel and colonic transit measurements in clinical practice as well. The main methods that are applied in clinical practice are substrate-hydrogen breath tests for small-bowel transit ...
Knight Linda C LC Department of Radiology, Temple University School of Medicine, Philadelphia, PA 19140, USA. - - 2012
The gold standard technique for measuring gastric emptying is scintigraphy using radiolabeled test meals. Recently, a standardized radiolabeled solid meal has been proposed and adopted by many centers. There is still a need for alternative meals, and several such meals with demonstrated radiolabel stability have been evaluated in small numbers ...
Liu Ping P Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2012
Dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing non-integrin (DC-SIGN) is a Ca(2+) -dependent transmembrane lectin that binds a large variety of pathogens and facilitates their uptake for subsequent antigen presentation. This receptor is present in cell surface microdomains, but factors involved in microdomain formation and their exceptional stability are not clear. ...
Allen Doug K - - 2012
The architecture of plant metabolism includes substantial duplication of metabolite pools and enzyme catalyzed reactions in different subcellular compartments. This poses challenges for understanding the regulation of metabolism particularly in primary metabolism and amino acid biosynthesis. To explore the extent to which amino acids are made in single compartments and ...
Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid ...
Teixeira José J CIQ/Departamento de Química e Bioquímica, Universidade do Porto, Porto, - - 2012
A novel mitochondria-targeted antioxidant (TPP-OH) was synthesized by attaching the natural hydrophilic antioxidant caffeic acid to an aliphatic lipophilic carbon chain containing a triphenylphosphonium (TPP) cation. This compound has similar antioxidant activity to caffeic acid as demonstrated by measurement of DPPH/ABTS radical quenching and redox potentials, but is significantly more ...
Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney.
O'Meara Elaine - - 2012
Clear cell sarcoma of kidney (CCSK) is classified as a tumour of unfavourable histology by the National Wilms' Tumor Study Group. It has worse clinical outcomes than Wilms' tumour. Virtually nothing is known about CCSK biology, as there have been very few genetic aberrations identified to act as pointers in ...
Varela Luis L Department of Physiology, School of Medicine-CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela (A Coruña) 15782, - - 2012
Hyperthyroidism is characterized in rats by increased energy expenditure and marked hyperphagia. Alterations of thermogenesis linked to hyperthyroidism are associated with dysregulation of hypothalamic AMPK and fatty acid metabolism; however, the central mechanisms mediating hyperthyroidism-induced hyperphagia remain largely unclear. Here, we demonstrate that hyperthyroid rats exhibit marked up-regulation of the ...
Edris Badreddin B Department of Pathology, Stanford University School of Medicine, CA, - - 2012
Soft-tissue sarcomas are a group of malignant tumours whose clinical management is complicated by morphological heterogeneity, inadequate molecular markers and limited therapeutic options. Receptor tyrosine kinases (RTKs) have been shown to play important roles in cancer, both as therapeutic targets and as prognostic biomarkers. An initial screen of gene expression ...
Ding Bei B Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, - - 2012
We investigated the molecular interactions of a cell penetrating peptide (CPP) Pep-1 with model cell membranes using sum frequency generation (SFG) vibrational spectroscopy, supplemented by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). Hydrogenated and deuterated 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG and dDPPG) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (POPG) were used in the experiments to represent gel-phase ...
Nair Jayasree S - - 2012
Aurora kinases are mitotic serine/threonine protein kinases and are attractive novel targets for anticancer therapy. Many small-molecule inhibitors of Aurora kinases are currently undergoing clinical trials. Aurora A kinase is essential for successful mitotic transition. MK8745 is a novel and selective small-molecule inhibitor of Aurora A kinase. MK8745 induced apoptotic ...
Patra Chitta Ranjan CR Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United - - 2012
GIPC (GAIP-interacting protein, C terminus) represents a new target class for the discovery of chemotherapeutics. While many of the current generation of anticancer agents function by directly binding to intracellular kinases or cell surface receptors, the disruption of cytosolic protein-protein interactions mediated by non-enzymatic domains is an underdeveloped avenue for ...
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Leaether Strip - I might be somewhat "stiff" in the muscles and I got a sore throat, but I'm still floating
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The comeback on the Alfa Matrix label in 2005 of Leaether Strip was Phase I in the Leaether Strip history, now comes Phase II. With his return to the concert stage Larsen is going in second gear finally showcasing his newest material live as well. And the new studio material from his "Aengelmaker" album is astonishing strong showing that although being very prolific, the Danish EMB master is able delivering material that holds several industrial pearls. We decided to wait right after Larsen's first 2 concerts in Denmark itself to get in touch and ask him some more details n his newest work but also about how it feels to be finally live on stage again... (By Elise Din)
SL: Tell me, how did you go to sleep the night after the first gig?
CL: We were home again around 5 am, and I woke up at 8:30 fresh as a Rooster in a henhouse. I bet I was still high on adrenalin, and a little stiff in the muscles after playing over 2 hours. The show was supposed to be 1:20, but the kids still had hungry eyes after that. I made sure to have extra songs ready, just in case. And what a night it was. It was like playing for my family. The atmosphere was so friendly and I didn't have any nerves. I felt like pushing the guest band "Mommy hurt my head" off the stage, so I could get started.
SL: How was it talking to the rabiat fans that came over for the gig?
CL: Just thinking about it now gives me goose bumps. Never in a million years would I have expected such friendliness and love. They really had waited for all these years for me to go back on stage. It was really moving that so many German people had driven for hours and hours to come, and most of the for both shows. Most of the Danes were people who had followed my music since my first release. With all that love an understanding one would think we were at a Grateful Dead concert. I did smell a little funny tobacco, while I was sitting at a table selling some cd's. I wanted to make sure that I could talk and thank everyone for coming. I remember from the last tour that Germans can be a little shy to ask, so I wanted to be there in case they had something to ask me. No hiding in the backstage room for me. The Danes don't have the problem hehe, they just ask.
SL: The first two dates have now been done, how does it feel and how did things go?
CL: It was amazing. Everyone at the shows including me felt what it was like to be 21 again. I bounced around like a teenager, and I have no idea where that energy came from. The crowd spoon-fed me with their positive aggression like they had something bottled up inside for many years they needed to get out. I for one did get it all out. The 2nd show was just as amazing. I ended up playing for over 2 hours again with no breaks, I went directly into the extra songs telling the people that why bather walk off stage and stop this fun. It was the most friendly and intimate shows I've ever played. I hope the other shows will have that vibe. I wish I can get that family vibe going at the other shows I'll be playing this year. Maybe I can even turn the whole Amphi festival into bouncing 21 year olds. Now that would be something. Anyway, I want to have fun at my shows, and I learned that if I give myself 100% chances are that someone in the audience will too, and it spreads like wildfire.
SL: You recorded brand new versions of several tracks, what did you add and why exactly those parts?
CL: The last 4-5 months I've been re-arranging and remixing songs for the shows, plus I also had to film and edit the projection movie. It has been hard for me not to have time to make 2 or 3 albums in those months, Just kidding. What I want is to make the people go "What the hell is this???" and then a few seconds later "AHHHH YEAHHHHH!" and then my plan is that they start bouncing. I also wrote 10 new instrumental songs that I have blended into the sets, and I will improvise some keyboards on those. Also because most of my other songs are so demanding vocally I wanted to do some live synth too. It's been hard work and right now I am preparing new instrumentals for the Gothenburg / Sweden concert on the 2nd of May. It's also sold out. Crazy and unexpected shit, but very moving.
SL: Knowing you, I wouldn't be surprised that every single concert will have a few changes, is that correct?
CL: True, no set will be the same. Every night is special. That is also one of the reasons I chose to not tour in the old destructive way. I don't want to destroy this return by overdoing it, like my tour in 92. I was butt-fucked by the people who arranged this tour because of greed. The shows were great and we gave what we had, but 3 weeks with one day off kills the fun. I was in bed for a month after that. Now I want to have fun and I want to play for people who Feel the same way.
SL: You told me a while back that you planned making the mixes that way that it would leave you some space to jam at free will, is that the case?
CL: Yeah the intros of the songs are longer and that leaves me room to do something. Maybe hit the pad or play some notes, or dance a little with the people. I didn't plan when I will do on the songs at all. I just go with the flow of things. I know I will get some heat from "the music police" for not having a couple of keyboard zombies behind me. It's usually other musicians that comes with those remarks, But Leæther Strip is me, and me is what you get this time. EBM is not about virtuoso keyboard playing and hour long solo's. It's about the aggression, energy and the power of the beats. EBM is not EBM without the sequencer. People shouldn't come if they expect this from me. And I also find it a little odd that, what I was told when I started playing Synths, "It's not real music when it's a Sequencer playing", still goes for some people. Get over it. And if they play a nasty keyboard live, then more power to them. I don't want to hide behind a Keyboard, I want to bounce around the stage. And with a belly like mine, I bounce like a champ!
Leaether Strip - "B M B" (Live in Aarhus 10th of April 2009)
SL: How would you describe the reaction of the audience?
CL: One word: Unforgettable. And I can't thank them enough for that welcome back I got the 9th and 10th of April. I even felt so Calm and happy that I started to add new lyrics to the songs and I even started to sing lines from "Sex dwarf" during "kill a raver" I do not dare to hope for the same on the other shows, but it happens I'll end up crying on stage like I cried happy tears in the car On the way home from the last gig. I haven't been this happy since the day I married Kurt.
SL: Now, back to the album "Aengelmaker", for me the second disc is the strongest part of the album. And I absolutely adore your version of "Deliver me"...
CL: Disc 2 is the "deeper and moody" one yes. I actually thought I mixed the tracks up on both cd's, but now that I got it at a distance I agree with you. "Deliver me" is one of the songs that can make my eyes water. I wish with all my heart that it was written by me, but it's a song by "The Beloved" I then heard it sung by Sarah Brightman at a concert I was at, and it touched me like no other song has done. Maybe because the "real" me was hiding most of my life and then I found my "life raft"
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SL: The whole concept of the album is based on the murder case of the Danish female mass-murderer Dagmar Overbye who killed at least 25 children between 1913 and 1925. During her trial, all the truth about her own abused childhood resurfaced. What did you want to say with this? Is environment that important that it can be part of an excuse?
CL: To put it really simple, it's about the Value of a life. The Angelmaker case is 100 years old but we still haven't learned the value of a life. In her case, she started out as a victim of abuse. It was ignored and she turned into the Abuser as an adult. Countries like our's who call themselves civilized are still doing these mistakes every day. Abuse is still tabu. It's a subject that makes my piss boil. Kids who are abused or killed don't have a voice. Kids are still being murdered either because they are handicapped or because girls aren't going to put food on their families tables. And if the girls live they sell them to pimps and get money that way. And still we deal with those countries.
SL: 'Angelmaker' in dutch also stands for someone who practices illegal abortions, was that part of the concept or just a side product? And does it involve any judgement from your part?
CL: The reason for the title "Angelmaker" was because that was the name the journalists gave Dagmar Overbye during her trail, when they wrote about her. It's got nothing to do with abortions. The mothers who gave their kids to her did it because they thought they would be spared form a live in poverty and have a happy future with the "Perfect" family, and then Dagmar went up to her apartment and stuck a knitting needle into the back's of their heads until they were dead, and then she burned them in her fireplace. She didn't even bother to remove the remaining bones from the ashes. At that time the stench in Copenhagen was horrible so no one took notice of the smell. Strong stuff. I would recommend the book but its only out in Danish sadly. Her story should be done as a movie. It really would show people what comes of abuse. Mentally or sexually.
SL: 'Don't you dare die on me' is an extremely strong statement song, have you been in cases where you felt like that? Please explain when and what caused this.
CL: It was one of those songs I dreamt. Both music and lyrics. I almost felt naked while writing the lyrics, because the feelings I got out, were something I have carried since I lost my Father to cancer. In the dream I was sitting beside my father's hospital bed, but when I looked at him it wasn't my father's face. It was someone very close to me who is still alive. And the line "Don't you dare die on me" was something I screamed in the dream into the face in the bed. Almost too personal to put out, but all my songs are from somewhere inside me so what the hell. And I got so many amazing messages from people telling me thanks for that song, and that makes it worth Releasing. It helped me a great deal to write it.
SL: Your version of "Lili Marlene" is a very loaded one, what does this song stand for for you? Did you get hold of the disc I talked you about with the original version by Lale Andersen?
CL: That song have been with me since I was a little chubby kid, hiding behind the sofa watching TV I shouldn't have, while my parents thought I was in bed sleeping. I had no idea what that song was about until I learned German. But I always felt really sad when I heard it. Some time ago I read that they finally placed a memorial statue in Berlin for the gay men who were killed and brutalized by the Nazis. And for some reason, maybe because I had this "sadness" linked to it, I thought of "Lilli Marlene". Yes I did buy that collection with Lale's version, and thanks for the tip.
SL: It's strange that this song became popular on both sides during World War II... it reminds me of the x-mas 'parties' German and French soldiers had during the first wold war.
CL: Yeah that's maybe why it means so much and brings so many feelings up in the people from that generation. There is also a Danish version of it from that era. I wonder what it would be like to write a song like that.
SL: Your 2 Depeche Mode interpretations on the album differ from the ones you offered for the label tribute "Alfa Matrix re:covered - a Depeche Mode tribute". I guess those songs were already in your head for ages to cover? I guess your versions are exactly what a rivethead wants from a tribute, harsh yet very loyal to the original version. What was the goal?
CL: Yeah I made the versions a little more "club friendly", the ones on "Aengelmaker" got longer intros. As I like to have my album songs. I like to build an atmosphere before the beat's and bass set in. Both songs are as everyone knows from "Black Celebration". That album is for me that most complete album ever made in music history. Alan Wilder really took Martin's songs to a whole new level, and he's to me the best arranger/producer around, and he should be ashamed of himself for not producing more of his art. Shame on you Alan! Hehe. Maybe I should give him a lesson in "how to not have a life and make music all day and everyday". Anyway, If it wasn't for that album I wouldn't be sounding the way I do now. And I am not ashamed to say that. He's is a genius, but a slow one. My original plan was to pay tribute the that whole album and cover the whole thing, but that's maybe one for a later time.
SL: What did you think of the new Depeche Mode single "Wrong" by the way?
CL: Maybe I'm the WRONG person to ask. If DM released an album with rare bird calls from the Scottish highland, I would love it. I'm a super fan and people like us are loyal to the bone. I have heard other songs from their new album and I am so happy they found the old sounds out and dusted them off. I could tell that it's not a club album, the songs needs some listening to grow on me, but the best album's usually needs that. I'm just happy they still are around. I don't like seeing them live anymore. I hate stadium shows. I keep my memories of the Black Celebration show I saw in Gothenburg/Sweden. And guess where I'm playing live to a sold out venue in the 2nd of May... yes Gothenburg. And the last time I played there many moons ago the kids were WILD! Swedes got to have their Herring, snaps and EBM to be happy. Skaal!
SL: So tell me, what is next?
CL: I want to get my "Dark Passages" soundtrack out soon. But due to this financial crap the movie was put on hold, and I'm sitting here With a full album I can't get out. Typical my luck, I finally get one of my dreams fulfilled and then some greedy Banks and investors starts a global crises to annoy the crap out of me... But the Director tells me it'll happen. I will release it no matter what, movie or not. But I'm giving them a chance to get going. I really worked hard on it. Its written from the script so I got to create my own little movie in my head, and I don't think that's been done before. I am also working on "Retention no.3". This time around it's "Solitary confinement" I get to re-master, rape and recreate. And if I find the time I'll be writing new songs too. But this year is mainly dedicated to the concerts. I got some interest from South America and south Africa and playing there would be out of this world. It's going to be a great year for me, I just know it! After the first 2 shows, I'm floating on air. I might be somewhat "stiff" in the muscles and I got a sore throat, but I'm still floating.
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subset: commoncrawl


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We've finally added support for the middle man between single and double opt-in subscriber lists. Known as 'confirmed opt-in', you can now send a confirmation email to any of your new subscribers when they join your list.
Doesn't sound all that exciting does it, but this little email can be a great way to get off on the right foot or encourage more subscribers. Here's a few ideas you can try:
It's also a good idea to show each new subcriber how much you respect their privacy by linking to an unsubscribe form where they can remove themselves from the list. You'll find that hardly any will ever use this option and it builds confidence in how you manage their details.
It would definitely be great if the confirmation could be an HTML e-mail. It's very weird when the newsletter is a carefully designed HTML template but the first impression the users get (the confirmation e-mail) has to be a plain text message.
I understand that if it had images you'd have to host them even when no campaigns are sent, but even just an HTML e-mail with remotely linked images (since there is no need for stats in this e-mail) would be great.
Please take it into account!
Very good point Guido, this is something that we've discussed in the past, but it's time we had another look at this feature.
Great! I'm looking forward to future updates for this.


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Hot answers tagged technology
The simplest answer to your question is that 1) speeds have increased; but 2) speeds would have increased even more except Tour organizers have been consciously making the Tour harder in order to increase the drama, suspense, and entertainment value of the race. That makes comparisons of overall winner's speed quite complex when combined with normal ...
There are a few "pseudo-facts" I think might be at play in this graphic:
You mentioned 10% of increase, say from 35km/h to 40km/h average speed. That is a VERY significant increase. Anyone well trained can sustain 35km/h average for some time even in a mountain bike, but FORTY km/h is MUCH HARDER to sustain, and that's because aerodynamic drag is ...
What really struck me though was that the average speeds really haven't changed much
The chart ranges from about 25km/h to over 40km/h, and that is a big change. As others have mentioned, increasing your average speed requires a non-linear increase in power applied to the pedals.
In other words, to increase average speed from 25km/h to 26km/h is easier ...
The Tour de France is primarily an endurance event, where team strategy is more important than outright speed. In addition there are UCI rules for racing bicycles.
This includes a 6.8kg weight restriction that has been in place since 2000.
If you want to compare outright speeds it would be more interesting to look at how the average speed of the time ...
I am not a bike expert, but a computer programmer. The problem with this question is that there is no control to compare it to.
Each year the TDF changes. They visit different parts of Europe, yes it is not 100% in France. This means you can't compare times between years.
Weather (not climate) is a concern. The temperature, wind and humidity will impact ...
I've had good success with the Go Pro cameras for whitewater kayaking. We generally mount them on our helmets. They stand up to quite a beating and you can get more on a card than the camera you ask about above.
If you can mount it on your helmet then it will be pointing where you look and I think you'll have better success getting shots of any collision ...
Years ago, when my wife and I started riding together, we got a pair of cheap two-way-radios, with headsets that included VOX. This allowed us to talk even when we weren't riding side-by-side. And since we weren't trying to talk from a mile away, it didn't matter how cheap the radios were.
Of course, this requires you coordinate with your co-worker, both ...
I dunno about upcoming innovations, but I reject the idea that nothing much has changed in the last 25 years.
Bike lights have improved enormously. I started cycling with the big EverReady-style lights that took two enormous D cells and gave only a few hours of rather weak light (that is, if the bulb didn't fail). If you wanted to ride for moderate ...
The answer is "both, depending." The majority of current bicycle cyclometers use a reed switch and timer, and measure the time between successive triggerings of the switch as a magnet passes by. An advantage of this method is its simplicity and low cost, though if the magnet is ill-positioned or if the rotational speed of the wheel is too high, the reed ...
I'd say the biggest change is the shift from coil and oil shocks to air springs. Even at the cheaper end of the market most bikes designed to go uphill will be using air shock suspension. Air suspension is lighter but in the past has performed less well and been more expensive. Over the years price has fallen and performance has improved.
The other big ...
The Rockshox at Paris Roubaix were a Greg LeMond thing. Whatever Greg competed in a few 'out there' cycling innovations came along with him. Remember those tri-bars that gave him the aero tuck position to beat Laurent Fignon in the Tour de France? On that event he also had his own road bars that had an extra position, where the drop handlebar end plugs would ...
Last year I plotted average speed versus race distance and there's an incredibly accurate inverse relationship.
But to add to my chart and flesh out the reason I think it hasn't increased so greatly. The Tour is a stage race. The average speed we have presented is the average ...
Folding bikes are getting better and there is still a long way to go in finding the best folding system.
Low maintenance is important for a lot of people, so better fully enclosed gears, chains and brakes are important to get normal people cycling, likewise with puncture-resistant tires.
It must be possible to come up with better locking/tracking systems.
Electric gadgets on bikes (while available now) will become mainstream.
Electrical bikes, not the ones your grandmother uses to go shopping, but electrical race- and mountainbikes. Implemented using invisible and low weight devices like the Gruber Assist.
You could also think about electronic shifters like the Dura Ace di2.
To me (and for others, I think) the greatest paradigm shift (that should become widespread in the near future, my opinion) is the inertial-controlled compression-lockout valve (Fox Terralogic, Specialized BRAIN).
These work as automatic lockouts, which make the bike stable if the rider pushes it down (like pedalling hard on a smoot uphill, or sprinting on ...
There have been designs, but cyclists tend to be picky about increases in weight or losses in efficiency.
Bicycles do not have the problems of large spinning masses or rough clutching at low speed, and we seem to do OK with discrete steps in the gear ratio.
Most bluetooth accessories (like headsets) expect to pair up with something smarter, like a cellphone or computer.
One simple alternative would be to each use a bluetooth headset and cell phone. Start a call at the beginning of the ride and stay connected until you finish or part ways. You will ideally need a cell plan that allows unlimited calling to a ...
I think current trends in simpler bikes with cleaner lines might help popularize (thus bringing the price down) wide-range internal gear hubs like the Rohloff hub.
On my wish list would be more focus on comfort (consider the timelessness of the Brooks saddle combined with newer materials/design) and reliability (could we get puncture-resistant tires that ...
This question makes a category mistake, I reckon. In that the Tour de France is not a competition done to finish an enormous amounts of kilometers as fast as possible -- as would be the case with a marathon for runners; where they athletes do indeed go faster and faster. The only aim the winner of the Tour has, is to be faster than the number two in the GC. ...
While not disagreeing with the first answer above I think there are a few more complexities that haven't been addressed.
Changes in bike technology are not linear but rather generational. Component improvements don't happen each year but rather every 3-4 years. Aside from pro and sponsored riders most riders would not see any value in replacing a bike for ...
The NuVinci® N360 is a continuous variable transmission that is roller based. It is marketed and used mainly on hybrid and low maintenance city bikes. They must have had some market success as they have been around since 2006. I recall seeing them at Interbike around that time.
More info in the internal structure
Belt-drive is on the rise. Supposedly much quieter than a chain, and no lube...
I tried the GoPro for a while and there were several things I didn't like about it, or where I felt it fell short.
I'm now looking at buying one of the "tough" cameras produced by almost all of the major camera manufacturers which have several advantages over something like the GoPro or the ATC3K.
Things I didn't like about the GoPro are...
- The weight on ...
There is a drive shaft bike available. Heck there is even a Wikipedia entry on it.
I have never tried riding one. But the thing about bicycles is they are pretty darn good, as currently designed. Brake innovations have come and gone (things like disc brakes on MTB's).
I am sure there are more.
Maybe a ski walkie talkie would do the job?
For example http://www.cordless-phones.uk.com/two-way-radios/two-way-radios/doro-wt87-mic-radio
I have ridden road bikes of all sorts over many years in road races, time trials and over many miles of general riding and club runs. For most of those years the bikes had forks made of Reynolds or Colombus steels but with a reasonable rake. In later years the rake decreased and in some cases disappeared altogether with the result that the front of the bikes ...
Suntour makes a significantly different designed road suspension fork I found on Wired Magazine while Googling. Here is the Suntour product page
Tapered head tubes are designed to work with tapered steerers, with the steerer designed to be used with a 1.5" headset at the bottom and 1 1/8" at the top.
The primary advantages of a tapered headtube are to allow for the greater bearing surface and stiffness of a 1.5" steerer and lower bearing surface while reducing weight (slightly) and allowing the use ...
As others have pointed out, The TdF is an endurance race. It's not about all out speed. For a better idea of how bike technology has increased, check out the list of Hour record holders. This is done on an indoor velodrome, with no other people on the track to the person can't draft. The premise is to ride as far as you can in a single hour. The ...
Think of a cyclocomputer as a hardwired combination of a calculator, a quartz-clock, and a dedicated CPU working with a buffer.
Each time the magnet closes the reed-switch, a request is sent to the clock to capture a time-stamp, a time-stamped event is sent to a buffer, and the wheel circumference is added to the current ...
Only top voted, non community-wiki answers of a minimum length are eligible


text:
Book your room at The Charm of Cascais
Twin Room, Pool View
Max Occupancy: 2 guests (up to 1 child, 1 infant)Superior Twin Room
Max Occupancy: 3 guests (up to 2 children, 2 infants)Junior Suite, 2 Bathrooms
Max Occupancy: 5 guests (up to 4 children, 4 infants)Grand Suite (with Whirlpool Bath)
Max Occupancy: 3 guests (up to 2 children, 2 infants)Standard Twin Room
Max Occupancy: 2 guests (up to 1 child, 1 infant)5-star romantic guesthouse near Cascais Beach
Situated near the beach, this romantic guesthouse is 0.8 mi (1.3 km) from Boca do Inferno and within 3 mi (5 km) of Cascais Beach and Estoril Casino. Manuel Possolo Hippodrome and Paula Rego Historical House are also within 1 mi (2 km).
Property Features
Along with a restaurant, this smoke-free guesthouse has an outdoor pool and a bar/lounge. Free buffet breakfast and free WiFi in public areas are also provided. Additionally, a beach bar, a poolside bar, and a snack bar/deli are onsite.
Room Amenities
All rooms are individually decorated and offer free WiFi and free local calls. Cable TV, premium bedding, and hair dryers are among the other amenities available to guests.
Information missing or incorrect? Tell us!Renovations & Closures
Hotel Amenities
Hotel Amenities
Dining options at the guesthouse include a restaurant and a snack bar/deli. Guests can unwind with a drink at one of the guesthouse's bars, which include a beach bar, a poolside bar, and a bar/lounge. Guests can enjoy a complimentary breakfast each morning. High-speed wireless Internet access is complimentary.
This Edwardian guesthouse also offers an outdoor pool, a terrace, and tour/ticket assistance. For a surcharge, a roundtrip airport shuttle during limited hours is offered to guests. Parking is available onsite for a surcharge.
The Charm of Cascais is a smoke-free property.
- Airport transportation (surcharge)
- Coffee/tea in lobby
- Concierge services
- Dry cleaning/laundry service
- Fireplace in lobby
- Airport transportation
- Total number of rooms - 8
- Limo or Town Car service available
- Number of floors - 2
- Terrace
- Beach bar
- Poolside bar
- Luggage storage
- Safe-deposit box at front desk
- Pool sun loungers
- Free parking nearby
- Self parking (surcharge)
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- Free breakfast
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- Billiards or pool table
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- Multilingual staff
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- Year Built 2011
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- Number of buildings/towers - 1
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Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Self parking (surcharge), Free parking nearby
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- Free local calls
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- Private bathroom
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- Individually furnished
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A complimentary buffet breakfast is served each morning between 9:00 AM and 10:30 AM.
The Charm - This poolside fine-dining restaurant serves breakfast, brunch, lunch, and dinner. Guests can order drinks at the bar and enjoy alfresco dining (weather permitting). A children's menu is available. Reservations are required.
Nearby Things to Do
The recreational activities listed below are available either on site or nearby; fees may apply.
- Windsurfing nearby
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- Scooter/moped rentals nearby
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- Golfing nearby
- Bicycle rentals on site
- Free bicycles nearby
- Sailing on site
- Golf lessons available nearby
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Check-in time starts at 2:00 PM
Check-in time ends at 9:00 PM
Special check-in instructions:
Check-out time is noon
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Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
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No pets or service animals allowed
No elevators
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- Airport shuttle fee: EUR 50
- Airport shuttle fee per child: EUR 25 (roundtrip), (from 1 to 12 years old)
- Self parking fee: EUR 5 per day
We should mention
This property offers transfers from the airport (surcharges may apply). Guests must contact the property with arrival details 24 hours prior to arrival, using the contact information on the booking confirmation. Only registered guests are allowed in the guestrooms. No pets and no service animals are allowed at this property.


text:
These are all good questions, IMO. Enter Dusty freakin' Baker. And welcome in as well, Mr. David Price.
These are all good questions, IMO. Enter Dusty freakin' Baker. And welcome in as well, Mr. David Price.
Would you changed the way you pitched if you were tied 1-1 versus up 2-1? I do not believe I would. I think I would pitch the same whether my team was down by a run, tied, or up by a run. My job is to get outs, not score runs. I get outs by k's or poor contact.
In the Stubbs intangible argument, I am not talking about some nebulous sub-conscious effect (like the "Ks make a batter feel dominated" comment by wheelhouse.) I am saying that if I was a pitcher, and I felt that my hard hit mistakes would often lead to outs, I would challenge every hitter except those with significant power.
#Indians manager Terry Francona just said Michael Brantley will play LF. Drew Stubbs will play RF.
I disagree. If I was the pitcher and a bloop single landed in front of Stubbs, it would not change the way I pitched unless there was a runner in scoring position. My job as pitcher is to prevent solid contact... if a poor contact bloop lands for a single, that is gonna happen from time to time even when I am pitching very well. I can give up one or two of these every inning and still pitch a shutout.
Conversely, if I gave up a bloop single that a CF dove to get, only to have the ball roll to the wall for a triple? That would have my blood pressure skyrocket.
The things that get into my head are my mistakes... be they walks or hard hit balls. If i give up a hard hit ball that I think is gonna be extra bases for sure and turn to see Stubbs calmly camping in front of it, I would relax.
Ideally, but since we're talking intangibles, I don't think it's unreasonable to speculate that a pitcher may be likely to press more if the team is trailing than if he's pitching with a lead.
Plus, while we know wins are an unreliable measure of pitching performance, pitchers still care about them, so the score of the game can have a psychological impact in that sense as well.
"I can make all the stadiums rock."
-Air Supply
Yes.. all that is possible, but I am not dealing with possibilities but probablities.
I do not see any reason that the typical pitcher would press more down a run than up a run. Personally, it would seem more reasonable to presume a pitcher will press more in an effort to hold a lead.. then the game depends more on him. If you are down a run, you could be perfect and still lose.
Although this makes complete sense (and I agree with you), many pitchers can't grasp this and apply it during the game setting. I've seen pitchers groove through the first half of a game, give up a bloop single (with none or 1 out) and let that spiral into a rough inning. I think this has to do mostly with the pitcher's psyche. Giving up a bloop hit off the hands on an otherwise great pitch is frustrating.
cincrazy (02-12-2013)
The Reds "D won many games for them last year, and it was rare to see a game slip away because of a ball that fell in the outfield, or was pushed over the fence. BUT, I cannot imagine, if these intangibles that Stubbs has were a significant factor, that many teams in baseball would not covet Stubbs.
Given that the Indians just signed Bourn, Stubbs doesn't appear to posses enough intangibles to have a team want to start him on a daily basis.
That being said, I will be surprised if Bruce doesn't end up in center. IIRC, he played there for 20 games or so his rookie year. Choo sounds about as sure of himself out there as I do of him - which isn't saying much.
Cursh14 (02-15-2013)
The Intagible Stubbs Effect Theory would hold more water if the Reds had a quality pitching staff during most of his time with the club. With the exception of 2012, it was average-to-poor.
Meanwhile, we know the misfiring at the top of the lineup helped make the Reds the most inefficient offense in baseball last season. In general a player's tangibles outweigh his intangibles.
Raisel Ghul, the Demon's Head
Make that a thing.
Scrap Irony (02-12-2013)
Drew Stubb's caught more air with his bat than balls with his glove.
And at the end of the day the ledger was more often in the red than the black, no matter how many accounting tricks were applied to the columns.
Scrap Irony (02-12-2013)
Stubbs' hitting, I believe, had a non-nebulous adverse effect on the other Reds' hitters.
Hitters perform better, I'd suggest, when they are surrounded by other good hitters. Simply, the pitcher can't pitch around anybody. Putting men on base with a Choo or a Votto or a Bruce coming up is dangerous.
Enter Stubbs. He has a lifetime .655 OPS against righties in almost 1500 plate appearances. He hit .213 last year. His strikeout totals speak for themselves.
Put Stubbs in an NL lineup, with the pitcher hitting, and with the usual limitations on most shortstops and catchers who often are primarily defensive players.
The result is enormous pressure on a very few hitters. This is particularly so against righty pitchers, with the Reds having few hitters who hit them very well recently.
Everyone on the team can't be a hitting star, but when a Stubbs hits .213 with a .610 OPS and strikes out about 30 percent of the time, I'd suggest that it has a very tangible impact on (a) opposing pitchers who can pitch around others to get to Stubbs, and (b) the other Reds' hitters who have to manage in a lineup with very few potent threats against righty pitching.
Last edited by Kc61; 02-12-2013 at 05:30 PM.
Boss-Hog (02-12-2013),M2 (02-12-2013),MikeThierry (02-12-2013),RedsfaninMT (02-12-2013)
I can't think of a hitter that doesn't want to hit the ball up the middle from the beginning of his at-bat. Those few hitters who are dead pull hitters aren't going to change their approach just against Cincinnati (or other poor CF defensive teams). Those that focus on hitting the ball the other way are typically situational hitters looking to advance runners; they, too, won't change their approach.
In other words, I don't think a lack of Stubbs in CF matters in the least to hitters.
As to pitchers, I believe they should recognize the pros and cons of the situation. For every gapper that gets through, Choo will be on base around how many times more than his predecessor?
As an aside, I vaguely remember Choo playing a very shallow RF against Cincinnati. If he does the same in CF, things may get interesting. I think Bruce and Ludwick can be solid to above average OFers with range enough to perhaps cover those gaps. (Both have proven plus to above average defenders for their careers.) I think it's possible that the Red OF defense may be much less of a hindrance for that very reason. The aggressiveness of Choo may boost the Red D almost as much as Stubbs' speed did. It would certainly help pitchers and pitcher memory/ aggressiveness.
"You can learn little from victory. You can learn everything from defeat."
-- Christy Matthewson
"Show me a good loser and I'll show you an idiot."
-- Leo Durocher
I'm definitely sympathetic to the idea that psychology plays a role in baseball. The problem is in generalizing.
Sure, Jay Bruce might get intimidated by a pitcher in one AB, which might then cause him to strike out. However, it is VERY difficult to say with any accuracy that ALL batters are intimidated in a certain set of circumstances -- much less to make a general principle out of that observation. There is so much variance that it makes "intimidation" almost impossible to predict or to test -- and quite a difficult thing to base the roles of your players on. When there are so many more measurable elements of the game, it makes to look at those, too, before just basing your decision on "psychology."
"Ill kind of have a foot on the back of my own butt. Thats just how I do things. -- Bryan Price, 10/22/2013
My take on baseball psychology in relation to Stubbs:
You'd have to be crazy to want Stubbs in the line-up every day instead of Shin Soo Choo..
"All I can tell them is pick a good one and sock it." --BABE RUTH
Having better players makes "the right time" or "the big hit" happen a lot more often. PLUS PLUS
Board Moderators may, at their discretion and judgment, delete and/or edit any messages that violate any of the following guidelines: 1. Explicit references to alleged illegal or unlawful acts. 2. Graphic sexual descriptions. 3. Racial or ethnic slurs. 4. Use of edgy language (including masked profanity). 5. Direct personal attacks, flames, fights, trolling, baiting, name-calling, general nuisance, excessive player criticism or anything along those lines. 6. Posting spam. 7. Each person may have only one user account. It is fine to be critical here - that's what this board is for. But let's not beat a subject or a player to death, please. |


text:
Press release from CNW Group
Contrans Group Inc. Acquires Mackinnon Transport's Van Division
Monday, January 16, 2012
Contrans Group Inc. Acquires Mackinnon Transport's Van Division12:31 EST Monday, January 16, 2012(TSX:CSS)WOODSTOCK, ON, Jan. 16, 2012 /CNW/ - Contrans Group Inc. ("Contrans") announced today that it has acquired the Van Division of MacKinnon Transport Inc. Through MacKinnon's court-supervised restructuring, Contrans has taken control of MacKinnon's Dry Van business and immediately combined it with Laidlaw Carriers Van LP, a wholly-owned subsidiary of Contrans. The purchase allows Contrans to assume the contracts of approximately 80 drivers and owner-operators, and sub-lease the required equipment to continue servicing the MacKinnon Van division customers."This is a real boost for the growth of our Laidlaw Van division," stated Contrans' Chairman and Chief Executive Officer Stan Dunford. "The combination of MacKinnon's Van business with our existing operations will provide a benefit to drivers and customers and will generate overall efficiencies. It has been a pleasure working with the MacKinnon team through their restructuring process and we are pleased to add this division to our group."For further information: Stan G. Dunford, Chairman and Chief Executive Officer, or Gregory W. Rumble, President and Chief Operating Officer Phone: 519-421-4600 E-mail: firstname.lastname@example.com Web site: www.contrans.ca


text:
There Stands My House
a memoir
your country
This ebook is available in the following countries:
- Australia
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The first English-language translation of the memoirs of Hans Keilson, one of Europe's most masterful and remarkable writers
In this unique work, which was composed in the 1990s and only recently rediscovered, Keilson brings back a bygone era in snapshots from a life spanning one hundred years. The external stations of this life — his youth in Brandenburg, his student years and the fast life in Berlin, his exile in Holland, his survival in hiding, and the loss of his parents — are framed by economic crisis, anti-Semitism, and war, but also by friendship, music, and hope. Hans Keilson reveals these themes in gentle, quizzical reflections and fragments, producing an unforgettable portrait of his time.
The memoir is followed by a beguiling conversation about Keilson's one hundred years of living and writing. It provides an incomparable insight into the man whom The New York Times recently hailed as 'one of the world's very greatest writers'.
less128 pages; ISBN 9781921942433
Read online, or download in secure EPUB
Title: There Stands My House
Author: Hans Keilson; Elena Lappin
- Academic > Literature > Oratory. Elocution, etc. > Recitations (in English)
- Academic > Literature > Periodicals
- History > United States > 20th Century
- Biography & Autobiography > Historical
- Biography & Autobiography > Political
- Biography & Autobiography > Military
- History > Holocaust
- History > Great Britain
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text: 02 November 2011 IN THE FIELD: Wolf Workshops In Oregon Posted by: John Motsinger | Leave a comment | Share: Defenders' wolf expert Suzanne Stone served as a guest lecturer last week for Portland State University's Wildlife Conflict Management Training Workshop in Wallowa County, Oregon. On Tuesday, attendees toured the Zumwalt Prairie, a high-elevation grassland beneath the Wallowa Mountains and one of the primary corridors used by wolves in Oregon. Suzanne discussed her experience working to restore wolves in the northern Rockies and more recently, working with ranchers and wolf managers to implement nonlethal practices to reduce conflict between wolves and livestock. (See Wolf Coexistence Partnership) Other guest speakers included Ed Bangs, former US Fish and Wildlife Service western wolf coordinator; Russ Morgan, Oregon Department of Fish and Wildlife wolf recovery coordinator; and Jim Akenson, executive director of Backcountry Hunters and Anglers. The workshop participants included state, federal and tribal wildlife and environmental agencies. Then on Wednesday, Suzanne participated on a panel of wolf advocates who discussed wolf management and recovery in Oregon. Though Defenders and our conservation colleagues don't always agree on tactics, we adamantly agree on the overall goal of ensuring that Oregon remains a place where wolves can thrive for years to come. We continue working both together and independently to make sure the state has the resources and plans in place to promote the full recovery of wolves over the long run. And finally on Thursday Suzanne met with ranchers, Oregon Department of Fish and Wildlife wolf managers, and the Zumwalt prairie ranch manager for the Nature Conservancy to discuss ways to further reduce conflicts between wolves and livestock in northeastern Oregon. Tensions have been running even higher this fall since a few area ranchers continue to suffer occasional livestock losses due to wolves. But some are implementing nonlethal deterrents and better husbandry practices instead of just fighting to try to have the wolves killed. This kind of collaboration is key to the long term survival of wolves in Oregon and has been successful in reducing losses of both livestock and wolves. Here are some photos from Suzanne's trip (all photos courtesy of Suzanne Stone/Defenders of Wildlife): PausePlayPlayPrev|Next Snow-covered Chief Joseph mountain looms in the distance. Cattle ranching is the dominant business in Wallowa Valley. Because you never know when (or where) nature will call Suzanne describes successful tools for reducing conflict between livestock and wolves. Suzanne joined Russ Morgan (left), ODFW wolf coordinator, and Jim Akenson, head of Backcountry Hunters and Anglers, for a tour of the Zumwalt Prairie in eastern Oregon. This notice from Oregon Department of Fish and Wildlife is posted to help people identify signs of wolves in the wild. Ranchers, biologists and conservationists are sharing ideas about ways to coexist with wolves on the landscape. Love 'em or hate 'em, wolves are becoming an iconic part of life in eastern Oregon. John Motsinger, Communications Associate John Motsinger is a Communications Associate at Defenders of Wildlife. He handles press coverage for critters in the Northern Rockies and Great Plains as well as Defenders' national work on the Endangered Species Act.


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Despite having less than three weeks to attract high school seniors to Vanderbilt, Head Coach Derek Mason announced an impressive list of 22 prospects that form the program's latest signing class.
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White supreme court jacket size small 360 shipped Black supreme court jacket size medium 320 shipped
Lol relax man it wasn't a statistic it was a reasonable number. Most of us live in ny or la not fickon Seattle so...oh the jacket is a whole different story.. I didn't buy that hideous thing because I don't need something on me that shouts "I'm right fucking here!" at night, and then would suddenly morph it's look due to some rain. I think if that's what they were going for then the concept was cool, but failed miserably. Also, it's just 3m material, the dudes working on highway construction or fixing your telephone poles are wearing it.. ehh.. but to each his own! If you like it, all the more power to you.
Bu if it means that much to u wear it while you go swimming for all I care. Your jacket not mine
Family is here, but I live in LA.You must live in Seattle.
White supreme court jacket size small 360 shipped Black supreme court jacket size medium 320 shipped
Lmfao it does not rain half the time are you fuckim retarded? Wowww hop of ma dick brooh relax bro, that too was a joke. (hence my name on here)
#SS14PlayboyGang #FW14NeopreneGang #SS15NYLEATHERBOIIS
WTB: Supreme Ombre Flannel red/brown '09 Medium/Large
#SS14PlayboyGang #FW14NeopreneGang #SS15NYLEATHERBOIIS
#SS14PlayboyGang #FW14NeopreneGang #SS15NYLEATHERBOIIS
SO lol, now that we've seen better images and angles.Ugly and clunky
Thoughts on the Lampin model?
"All lives end. All hearts are broken. Caring is not an advantage."
Keep It Gully
"baller futuristic groovy gangsta with an attitude"
Fucktard we been developed a ratio
my opinion on this season's collabs...Pretty much my thoughts exactly. Although I did think the PCL Eras were nice after seeing them in person.
vans - PCL pattern does not work on the shoes...also the price was laughable...pass..
CDG - digi camo grew on me...bought the loop collar and did not regret it...wish i bought the long sleeve also...pretty damn good capsule collection albeit pricey
TNF - bought the backpack but the jacket was just laughably expensive for what it is...
Misfits - i don't like the misfits but thats not what stopped me from buying...the designs fell short...pass
Nike - of all the shoes they could have used that would have made a modern classic...squandered opportunity...
Clarks - good choice of shoe, good color choices, terrible pattern thrown on top...
not yet dude.and to all the people who viewed the video THANK YOU.upvotes and downvotes all appreciated seriously.the mixtape will be coming out this june.i will def keep who is interested posted.but once again much love to those who viewed.whether yu liked it or not yu gave us a listena few days back i posted a video of me and my team getting interviewed by ryan hall.as some of ya may kno me and my team do music and we go by the name of SORS.we are just a bumch of youngings thats into urban wear,video games,smoking and anything you are probably into lol.here is the music video that we shot the same day we got interviewed.i kno some may like it and some may not but i just wanted to share this with ya.thank youyall got a mixtape out?
No you just wear it when it doesn't rain... The fuck is so complicated about that....Buying a North Face but not wearing it in inclement weather is the epitome of hypebeasting. Copping Supreme but never skated types.
^ I actually don't know what he said lol that's the point I'm making though. I don't really get why you would wear this jacket in the rain TBH. Preety dumbYou don't know why some one would wear a weatherproof jacket in the rain?
Nudes of the broads in the video, we know you have them protoscum. Run it.lmaooo its crazy cuz i used to have one of their nudes in my email but tht was in h.s.
if i could turn back the hands of time i would of def copped the dogs and ducks coat.its soooooo crazy i would walk in the store and just look at it and say imma cop it but then end up buying some other piece.whoever got it i praise you for pulling the trigger.thts def a future grail TO ME.i can care less if its not to the world lol
"baller futuristic groovy gangsta with an attitude"
hell yea!!! i think the red one was the weakest one but the black tho.......fire!if i could turn back the hands of time i would of def copped the dogs and ducks coat.its soooooo crazy i would walk in the store and just look at it and say imma cop it but then end up buying some other piece.whoever got it i praise you for pulling the trigger.thts def a future grail TO ME.i can care less if its not to the world lol
very true, im starting to regret not coping the crosses jacket, but i ended up getting the schminx hoodie which i wear everyday
Looks like an Old Navy x Supreme collab
Got one of my personal grails today. Got the black colorway in a large off ebay for $125. Smiles for days.
guarantee the pcl bucket will drop with the vans just like tee dropped with the sbs gotta keep the ugly to piff ratio on point every ThursdayLol tee didnt drop with the SBsâ¦


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Janie Coyne, M.S. has been an employee of Medical Park ENT since April, 2008. Originally from the Eastern Shore of Maryland, she earned her Bachelor's degree in Speech Pathology and Audiology and her Master's degree in Audiology from Penn State, where she also completed her clinical fellowship year. She has worked in acute care and rehabilitation hospital settings and enjoys working with patients of all ages. She and her husband live in Selinsgrove and have two teenage daughters. Janie enjoys the outdoors and is involved in church and community activities.
Deborah is originally from Pittsburgh and earned her Bachelor of Science at Clarion University in Speech Pathology and Audiology. She then went on to Kent State University to obtain her Master's degree in Audiology. She has also worked as an audiologist at Children's Hospital in Pittsburgh. Deborah has nearly 30 years of experience in the field and has worked at Medical Park ENT for 26 years. She became interested in audiology because her father has a hearing loss and she saw first-hand how a hearing loss can impact the entire family. She finds tremendous satisfaction in helping others identify and overcome hearing difficulties. Debbie and her husband Tim live in New Columbia and have two grown children. In her free time she enjoys travel and singing in church and community choirs.
Suzanne is originally from Long Island, New York and graduated from Adelphi University with her B.S. in Speech Therapy. She then moved to Central Pennsylvania to work with the Department of Public Welfare. After that, she worked for the Pennsylvania School for the Deaf in Philadelphia while completing her graduate work in Deaf Education and Audiology at Penn State University. Suzanne moved back to the Union County area to work for the Central Susquehanna Intermediate Unit. She is a retired licensed teacher of the deaf and was thrilled to join our staff as a licensed Audiologist to continue her career in hearing rehabilitation.
Our experienced team will perform a diagnostic assessment of your hearing. Based on the results they will use their expertise to recommend an appropriate course of action to improve listening and hearing skills. We take your hearing health seriously, and enjoy improving lives through better hearing. Call today to start hearing better.
Sunday | Closed |
Monday | 7:30 am - 5:30 pm |
Tuesday | 7:30 am - 5:30 pm |
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High Risk Pregnancy Group Calculator
Pregnancy is a momentous phase in a womans life. Preparing for motherhood and at the same time feeling the baby grow inside the womb makes this a very special period of life. However some mothers need more care, understanding and support than others because they belong to a high risk group. Find out if you belong to the high risk group using our calculator. High risk pregnancy is harmful to both the mother and the fetus and can mean birth-defects, fetal deformity, miscarriage, still-birth or even worse, death of the mother. If your pregnancy falls in this category then consult your doctor and follow some of the advice that will appear in our result page.
Facts about High Risk Pregnancy
❖ | Major reasons why around 80% of mothers die at childbirth (or maternal mortality) include:
❖ | Women who have had given birth to more than four babies are at higher risk of dying at childbirth (maternal mortality). |
❖ | It is found that the maternal mortality rate is higher in case of poor and less educated women. |
❖ | The recent survey conducted by WHO reveals the shocking fact that nearly 3 million girls between the age group of 15 and 19 have an unsafe abortion every year. |
❖ | Babies born to adolescent girls are at 50% higher death risk than babies of women between 20 and 29 years. |
❖ | It is estimated that more than 3 million newborn babies die every year and around 2.6 million babies die in the mothers womb. |
❖ | According to WHO, an estimate of about 16 million adolescent girls (teenagers) mostly belonging to low-income and middle-income countries give birth every year. Adolescent girls are at high-risk if they get pregnant. |
- http://www.health.gov.au
- http://www.nichd.nih.gov/health/topics/high_risk_pregnancy.cfm
- http://www.who.int/mediacentre/factsheets/fs364/en/index.html
Post your Comments
ARSH_KHAN Friday, February 13, 2015
what is the home remedy for that.
nwamaka Thursday, August 25, 2011
mogli_786 Wednesday, March 09, 2011