text:
Code covered by the BSD License
by Ikaro Silva Ikaro Silva (view profile) 16 files 275 downloads 4.66497
11 May 2010
Dynamically performs weighted averaging and SNR estimation under a non-stationary noise.
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Given a NxM data matrix where N is the epoch length and M is the number of trials, WNSFMP returns (among other):
w- weight for each trials estimated by dynamically segmenting the data matrix into regions where noise is locally stationary ave- the final weight average snr - the estimate SNR and residual noise levels under weighted averaging and normal (uniform) averaging.
The function is implemented recursively and through the use of PERSISTENT variables. So that multiple calls to WNSFMP allows it to calculate a running statistics in case loading of entire dataset is not possible
See also: Silva,I, "Estimation of Postaverage SNR from Evoked Responses under Nonstationary Noise", 2009, 56(8)
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Season 13 Collections Shown at
Mercedes-Benz Fashion Week
Thursday, October 08, 2009
Results In - You Were the Judge Episode 7
Our polls for Episode 7 are closed. You disagreed with the judges and felt that Carol Hannah Whitfield deserved the win.
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Check back with us tomorrow for our Episode 8 poll.
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Mon-Fri: 7am-1am EST / Sat-Sun: 7am-11pm EST
If you placed an order on ApplianceHelp.com the order is still valid and you can check on its status and make changes here on PartSelect.com. Click here for more details.
ApplianceGeneral Electric Dishwasher
Level of DifficultyReally easy
Time to do repairLess than 15 mins
Age of Appliance5 - 10 years
Tools Screw drivers
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Removed top screws to allow the ability to remove control dishwasher control unit. Remove door parts & be careful how you remove them & put back the door parts the same way.
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A slick coated finish and low-rise silhouette contemporize a pair of slate-grey skinnies for a smoking-hot finish.
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Lauderdale Lakes, FL
Osprey Portrait
Anne Rodkin
Photograph - Photography
Majestic Osprey staring into the distance.
August 9th, 2012
Viewed 166 Times - Last Visitor from Beverly Hills, CA on 05/02/2015 at 4:20 PM
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Catskill, NY - United States
Wow - what a magnificent closeup of this osprey. Colors and detail are fabulous!
Santa Cruz, CA - United States
WOW, this is awesome! Such a nice close up and you can see how fine the feathers are and the detail in his eye! AMAZING!
B S, MO - United States
What an amazing creature You did it beautifully here Anne! :) One of my Twitter picks of the day! :)
Iola, WI - United States
Awesome capture and detail presented in this grandiose shot of the osprey, as it is one gorgeous avian. Thanks so much for sharing this beauty with us, Anne!
Puyallup, WA - United States
Another nice capture.. You Rock girl!! v
Anne Rodkin replied:
Ron, you're making me blush!! Thank you so much. This is what I love to do......... animal and bird portraits!!
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text: Welcome to the East Dallas Lakewood Early Childhood PTAEnriching the lives of East Dallas ChildrenThe Lakewood Early Childhood PTA (LECPTA) is a network of more than 500 Lakewood and East Dallas families of expectant parents and parents with children from birth through Kindergarten. We are a huge support of each other through the hardships, and joys, of parenthood. Our group is a resource of information on parenting, daycare, education systems, neighborhood activities, support from other moms and dads with kids of the same age, and have a lot of fun! We encourage community involvement throughout the year with membership-sponsored events, including holiday parties, adult outings, speakers, kids' activities and playgroups, all organized and run by our board members. There's something for everyone! Join us, enjoy all we have to offer and become a part of our cozy East Dallas/Lakewood family. Click here to join! Annual Safety Day - May 2Meet your local community heroes...Police officers, firemen, game warden, and the K9 unit too! Enjoy face painting, crafts, and cool down with an ice cone from Kona Ice. This is a child favorite and you don't want to miss out! CLICK HERE for more details2015 Sign up Party tickets availablePurchase tickets for the LECPTA Sign up parties! Acoustic concert, Catamaran Cruise, Disco Party, Crawfish Boil, Father/Son football bowl...OH MY! Purchase Sign Up Party tickets Make a Difference with LECPTALECPTA is the first step in getting involved and making a difference in our children's development, schools and community. Start the new year making new friends, sharing ideas and having fun with us. We welcome anyone interested in joining our group and hope to see you soon! Learn more about joining LECPTA |


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bruce lee of mma
edit: bruce lee was 135lbs 5''8' and 3% body fat. nobody expects an athlete to have such a low body fat, so with the body fat it would be closer to 145-155lbs. which wec fighters could resemble bruce lee in physique or strenght and fighting ability? they also need good boxing and kickboxing
Bruce Lee Roy is the correct answer.
Not again. Please, not again.
^^^This :sarcastic12:
I'm sure any of the guys listed would pass that test with flying colors. The fact is that guys like Bruce Lee and Antonio Inoki were ahead of their time. They just set the standard for the fighters today!:thumbsup:
Whoa Whoa Whoa.... You think these guys tould be able to :
10 repetitions of 70-80lbs bicep curls 50 rep one arm chin ups one hand/two finger pushups ? Noooooo.... LOL. That's a rediculous "test" |
Hypothetically speaking if Royce Gracie and Bruce Lee fought in their prime, I'm sure it would possibly be close cause Bruce was always willing to evolve while Royce brought the best of BJJ to the sport. If nothing else it would only motivate Bruce to incorporate elements of BJJ into his Jeet Kun Do fighting system. Overall I think it would've been an interesting fight!:thumbsup:
Watch what moves?:confused:
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Hurry, hurry! We've only got a limited number of new sofas in stock. Once they're gone, they're gone!
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"I use this for my recreational team, the net has held up well for taking it up and down now for over 2 years." (E1632)
"These flags are well made with a comfortable handle, and they look great on the field." (E399)
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Whitefish Bay has 6 schools. Some of the best schools in Whitefish Bay are Richards Elementary School with a GreatSchools rating of 10/10 and a parent rating of 5/5 stars, and Whitefish Bay High School with a GreatSchools rating of 10/10 and a parent rating of 5/5 stars. The average GreatSchools rating for Whitefish Bay public schools is 10/10, with an average student/teacher ratio of 15:1.
School data provided by National Center for Education Statistics, Maponics, and GreatSchools. Intended for reference only. GreatSchools Ratings compare a schools test performance to statewide results. To verify enrollment eligibility, contact the school or district directly.
The supply of housing inventory exceeds demand. Buyers have the advantage over sellers due to the abundance of homes on the market, with homes often selling at reduced prices. Price drops are common as sellers compete to find buyers.
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For Sale: 370 | New: 79 | ||
$480,126 | $384,181 | Recently Sold: 272 | Reduced: 131 |
Average Home Price | Average Sold Price | Property Records: 6,694 | Foreclosed: N/A |
The average home price in Whitefish Bay is $480,126, which is 25% higher than the average sold price in Whitefish Bay ($384,181) . The average home price per square foot in Whitefish Bay is $202 and about 4% of all homes in Whitefish Bay sold in the last 6 months. For Whitefish Bay home values, real estate prices, and city market trends, research the 6,694 property records or search our 272 recently sold or 370 homes for sale listings. The listings and properties in Whitefish Bay are only a part of the 1,807,706 properties and 45,066 homes for sale in Wisconsin. Because of this, the average home price and average home value of Whitefish Bay also influence the average home price $138,808 and average sale price $177,419 of Wisconsin. Listing counts, Whitefish Bay home prices and home values in Whitefish Bay are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.
14,129 | 39 | $112,741 |
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Home > Dorset > Dorchester
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Surrounding Postcodes:
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Dorchester, Weymouth, Portland, Sturminster Newton, Sherborne, Wareham, Blandford Forum, Bridport, Beaminster, Yeovil
West Dorset District Council [i]
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Transit Van | 450 Cubic Feet |
3.5 Ton Luton Van | 700 Cubic Feet |
7.5 Ton Truck | 1400 Cubic Feet |
HGV 17.5 Ton | 2200 Cubic Feet |
40 Feet Trailer | 3000 Cubic Feet |
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1 Bed Flat / Studio | 300 Cubic Feet |
2 Bedrooms Flat | 650 Cubic Feet |
3 Bedrooms Flat | 1000 Cubic Feet |
2 Bedrooms House | 700 Cubic Feet |
3 Bedrooms House | 1400 Cubic Feet |
4 Bedrooms House | 2200 Cubic Feet |
5 Bedrooms House | 3000+ Cubic Feet |


text:
Americans had to really want to see this movie
Permalink +Wed, Jun 30, 2004, 7:00 pm // John Servais
No showing of Fahrenheit 9/11 in Bellingham this past week. Why not? Because Regal Cinema booked the rights to show it but waited to see if it was well attended. Regal controls all three movie theater complexes in Bellingham. It will now start at the Sehome theater. If the movie had not done well they would not be showing it in Bham. Shame on them.I recommend you see the movie at the Cascade Cinema in Burlington - only 20 minutes south on I-5. Great seats - better screen and much better sound system. It is a fun experience to go to a movie down there. Much better than any Regal theater in Bellingham.
You can phone for show times. 1-360-707-2900 Here is what it says today. Fahrenheit 9/11 at 11:20 am, 2:10 pm, 5 pm, 7:40 pm and 10:20 pm. Take exit 229 off I-5. Exit 230 also works as it is between them.
The Pickford Cinema in Bellingham will be showing the movie this fall when it is done in the first-run theaters. The Pickford, while being small, is also a fun place to see a movie.
What is amazing is the movie racked up $27 million in revenue in less than a week even though only 868 theaters showed it in the US, instead of the 3,020 that are showing the dumb Dodgeball. Americans had to really want to see this movie. They are giving it standing ovations at the end of the movie. The news media are doing their best to rank it - to no avail. It is averaging $27,568 per theater - check for yourself. The website Box Office Mojo follows movie revenues. This is more per theater than Shrek 2 or Return of the King. The media are under-reporting this cultural phenomenon.
Related Links:
-> Box Office Mojo
Commenting is disabled for this post
Americans had to really want to see this movie
Wed, Jun 30, 2004, 7:00 pm // John Servais
No showing of Fahrenheit 9/11 in Bellingham this past week. Why not? Because Regal Cinema booked the rights to show it but waited to see if it was…0 comments
Leave no proof behind
Thu, Jun 17, 2004, 7:07 pm // John Servais
From a friend who is an enlisted person in the military - in a combat unit. The officers - the lieutenants - of his unit lectured them this…0 comments
Village Books
We are remembering Reagan for the wrong reasons
Thu, Jun 10, 2004, 7:10 pm // John Servais
and we will suffer for it. Reagan did not win the Cold War. Communism was systemically fatal - just as all the conservatives kept saying. Reagan did do…0 comments
Mercury in Lake Whatcom
Thu, Jun 03, 2004, 7:15 pm // John Servais
Today the Washington Department of Ecology released a report that says, basically, that mercury in the lake is less now than in the past. "Decreasing" is the operative…0 comments
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Alan has been with Pickrel, Schaeffer and Ebeling for over 40 years, working in the firm's Real Estate and Business Department. Alan represents buyers and... more
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Co-Founder of @GroupTalent (Funded by @Techstars Seattle '11), Co-Founder of Team Apart (Funded by YC S'08), BA in CS at University of Washington
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I have a confession to make... I skipped my workout of Friday. We went out to dinner to celebrate dd's great report card. By the time we got home, I wasn't feeling well. I did my workouts yesterday and today though. I'm hoping to double up sometime this week, so I can still start level 2 on the 11th. On a brighter note, I was way under on my calorie intake today. I started the day with an indulgence (went to a movie with 2 girlfriends to see Les Mis) and had nachos and an icee, but then was so busy at home after that, I didn't snack or anything. And I got all my Christmas decorations put away, dd's closet purged and organized, all gifts put away, and 7 loads of laundry done!!! Sent from my iPhone using DISBoards
I actually skipped yesterday too.. In my defense, it was scheduled c25k but it was raining and I didn't want to break up the middle of my day by going to the gym (it didn't open until 12:00 noon). Soooo, I got my running in this morning and I'm proud to say that I actually ran for 2 miles! That's a HUGE deal for me! First time I've actually run that all the way without having to break it up with a walk. So I have a huge non-scale victory to start my day with! How was everyone else's weekend? Hops&dreams - How was Les Mis? I really want to go see it! LittleMissMickey - I've opted to wait on Jillian at least until I get a new sports bra (jumping jacks HURT) or until I'm below 200lbs. Whichever comes first
Desiree -- please send the Whoosh Fairy to me!!! i'm doing pretty good...made it to the gym again this morning. i have 4 workouts planned and will be thrilled to get three in. I'm also weaning a step down on my steroid dose this week and it will slow me down.... and i bought a fitbit! my DD got one too and a couple of my friends have one so we are cheering each other one. i'm not really sure where to put my steps goal to be since i'm still recovery, so i'm trying 7,000 to start. i got over 6,000 today and i'm pooped! that was including my workout...a normal day for me without a workout was a pathetic number of steps! it was a little pricey...so i cashed in some best buy reward zone cert so i felt like it was more 'free' ...hehehe but it's a new gadget to get me excited! i remember when my new gadget was a Palm PDA that i downloaded a free verson on WW journal on! i'm dating myself!!
Just a really fast post tonight, because I'm tired and I need to go to bed... the flu is running rampant at my school, so I want to make sure I have all of my defenses up! I'm two days in with Jillian! I actually made a little something to motivate me: I took 2 little decorative glasses, put 30 little rocks in one of them and as I complete a Jillian workout I move a stone over into the empty one. Hopefully it helps keep me accountable. Congrats to Desiree on the two miler! I finally went and ran with the run club at my gym because I was motivated to keep up with YOU! Keep at it! ohMom - I want to try a FitBit so badly! Let me know how you and your day compare to what you expected, please! Jhenn - Another want -- I hope to go see Les Mis this weekend... I also want my house to be as clean as yours! Thanks for giving me a place to report to; this place serves up some great inspiration stew! (I just really wanted to use that little guy... never used him before!)
Ohh oh I'd love to know how you like the fitbit! I'm very curious how accurate they are! Ahh Palm PDAs, I remember thinking at the time that those were the pinnacle of technology! Great job on those workouts! What a great idea about the glasses/rocks! Keep up the good work! Hope you don't catch that nasty flu. My dd has been sick the last few days. I think her cough is FINALLY starting to loosen. Thanks! I'm really proud of how I've done this week between exercise and food intake. Now if I can just keep this momentum going!
good morning buddies! so far i really do like my fitbit, i bought the "one" which is a little more expensive. my mom has a fitbit and told me to get this specifc model and it does alot. It tracks steps, floors, calories burned, activity level, sleep and food which i link to MFP. honestly i don 't know how truly accurate it is, but it seems telling. does that make sense? i'm really glad i bought it. there is an app for phones too, i have iphone and it works great; my DD has android and says it doesn't work great at all. if you have specific things you want to know about it, ask away! today is a rest day from workouts and i need it! now to just be careful about what i eat so i don't blow the day. DH and I are booking a getaway to Vegas with my bestie and her DH, in 7 weeks and i really want to lose 15 lbs before we go!
Do you have to specify what you are doing each time? (like walking up stairs, walking on dreadmill - no that wasn't a slip lol, elliptical, etc?) Vegas sounds like a fantastisc getaway! You can do it! Today has been good so far here. I went to the gym since it's Week 8, Day 2 of C25K and each time I run in the gym my gps doesn't work so Endomondo couldn't get an accurate reading. So, I just kinda winged it with what I put in MFP and copied Monday's run from there. And I think that's gonna be it for me on the exercise front today. I did go to the gym last night and the plan was to only do a quick 35 on the elliptical but I started watching the tv show Luther on my phone and the next thing I know, 55 minutes had passed! So with that extra, I think I'm going to go straight home from work, get in my jammies and finally watch Downton Abbey from Sunday off the dvr before hubby gets home! I may even have a glass of wine! Oh! I'm also toying with the idea of signing up for an actual 5K. The original plan was to finish the program (next week!!!!!) and then work on improving both time and distance before signing up for a real one. But I'm an avid LSU fan and one of the local charities is sponsoring a 5K that will involve alot of ex-LSU players. Soooo any chance to be in the vacinity with some former baseball players sounds like a good excuse to me!
I need to be motivated. In 2010 i lost 80 pounds. In 2011 i maintained this loss, in 2012 i gained 25 pounds. So my goal for 2013 is to lose these pounds. I have started walking on my lunch and breaks and i have changed my eating habits. Not counting calories (even though i should) so im not sure if i am even making any headway.
it automatically tracks stairs and steps. I do enter my workouts in MFP and it syncs. I have not walked on the treadmill with it, but i'm fairly certain it would count those steps as it did so when i workout out on the elliptical. It did not add 'steps' for the day when i rode the exercise bike. make sense? here is what the 'dashboard' looks like which is what it automatically tracks, rough looking as the icons didn't copy over: Activity 484 steps taken today 7% of goal of 7,000 . 0 floors climbed today 0% of goal of 10 Only 1 floor to get to your first milestone .. 0.2 miles traveled today 4% of goal of 5.00 . 601 calories burned 25% of goal of 2,407 . 65 active score 6% of goal of 1,000
Desiree - oh, sign up for a race! Races are SO fun! I LOVE them because there are usually so many people to keep encouraging you. The volunteers are usually so cheerful, and the spectators really keep you psyched. Most of the time, I hate running, but then I do a race, and remember how fun it can be. I tend to get caught up in the excitement. I hope to someday do a RunDisney race. You'll find out quickly that there are good races and bad ones. A good race has a good course, an organized team that's running it, and great sponsors, which means good freebies! While I don't run races only for the freebies, I do enjoy them. My favorite is Wine at the Line - (at a local winery in the early fall). Thy give you a shirt, hat or gloves, and a wine glass (filled at the finish line!) Oh Mom - That Fitbit sounds awesome - lightyears ahead of my pedometer. I'd be curious to see your activity on a normal day vs a day at WDW. I've always wondered how much more we actually walk at WDW. Last year, I wore my pedometer, and it tracked that we walked between 6-11 miles every day. (the 11 mile day was our Epcot day) Goofy Figment - Welcome! Jump on in I totally needed this thread today - thank you all for being so inspiring! Confession time : my last workout was on Sunday!!! Work's been killer and I've been staying later, which is my normal time to sneak in my workout. I had company right after work on Tues. Last night, I didn't get home until after 8:20 after running errands for Girl Scouts after a late night at work. I'm totally a stellar mom - I didn't feed her dinner until after her normal bedtime. Tonight, we have our meeting. But after reading all your hard work, you've made me realize I need to do it too! Next week, I will start waking up early to work out, so I can get it done and out of the way before work. Does this count as a new resolution? on a brighter note, I am keeping up with logging my food, and staying under calories. I've been resisting temptations to do the easy thing and eat fast food or order out. I've been cooking and bringing my lunches and snacks. At least I'm sticking with one part of my cliche resolution... but we're only 10 days in. I still have plenty of time to break that one too!
I love that it automatically tracks stuff and syncs! That's great! OH I can definitely get into a 5k that gives me free wine or beer at the end of it I had an out of sorts day yesterday. I got my run in early and all my food planned out but then when I got home last night after picking up dd from her work and saw the kitchen, I just didn't want to even tackle it. Plus Dev wanted me to help her color her hair so I knew if I sat down that wouldn't get done either so we talked hubby into ordering chinese food last night. By some miracle I still came in below on calories but I felt like I overate. So the 3 pounds that I lost on Wednesdays weigh in seemed to show back up on the scale when I peeked at it this morning. So back on plan today and now I still have to clean the kitchen and get to the gym tonight. Blah! But tonights menu is some talapia so at least that's a better choice than sesame chicken!
What motivation I had Wednesday has gone completely out the window yesterday. Ugh. Maybe it's the rain that we have been having. It's been pouring here since Wednesday. Yea, best laid plans, I totally bailed on going to the gym yesterday. But... this is make or break time. Once I feel I start to waiver, I just need to push through this. I know how I am. It will be one excuse after the other so maybe if I write this plan down I will stick to it. C25K run tonight after work and after I bring dd to her job. Gym in the morning and then I'm starting week 9 of C25K on Sunday. That is the last week and this will be the first time I've ever completed the whole thing (after 3 attempts in the last few years). Sooo I WILL do this. If I make an excuse, someone please fly down to Louisiana and slap me.
Desiree- I've been looking to take a vacation- shall coming to slap you be my excuse? ;-). Especially if there's sesame chicken involved. Haha I'm totally over on calories today, and I will be tomorrow as well. Ate out for dinner tonight, and dh and I have 4 hrs to kill while dd is at a birthday party tomorrow, which is a good 40 mins from our house. So dh and I will most likely go to a brewery or pub to kill the time and I will drink and eat way too many calories. Monday is a new start!!! Sent from my iPhone using DISBoards
Absolutely! But we have a lot more down here to eat that's good than sesame chicken! Of course, most of that is probably why I'm the size that I am. (Curse you bread pudding, fried catfish, and crawfish etoufee!) Ouch maybe you can get some exercise in at least too. (I know I'd be hard pressed to turn down a beer or two though). Is there a mall or something you can go window shop and kill some time in? At least that way you would be walking a bit! Yesterday turned out to be a bit better than I had originally thought. I started off being so UN-motivated that it wasn't even funny. But I got to work, stayed OP with my food (at least until Dinner but that's another story..) And my co-worker and I decided to reorganize our storage room. We had sorted the incoming boxes of monitors/computers and printers the day before. So we spent the better part of about 3 hours moving pc equipment to the pile that goes to be obsoleted, clearing off shelves and labeling and sorting cords. It wasn't fun but we got it done and it looks great. A vast improvement from what it was before. So after work I dropped dd off to her job (man I can't wait to she gets her car back!) then went back home and got ready for the gym. I finished Week 8 of C25K and actually did a bit more. I ended up running through both of my cool downs for a total run of about 38 minutes - which is my longest run geez, since I was in high school *gulp* 20 years ago. And then I did weights after. So today I have been blessed with a rare day to myself! DH and I usually pretty much do everything together and trust me I'm grateful for that. I love him dearly, but I find myself almost giddy at all the possibilities! Dev doesn't work today but she has plans with her dad and stepmom and their kids. I'm going to go put in some time at the gym today. Maybe just 30 on the elliptical and then I want to come home and tackle the house and laundry. Maybe get through the episode of Downton Abbey that keeps getting interrupted. I also want to re-organize my kitchen cabinets and get the entire floor scrubbed. And of course, the dreaded grocery store. But I also want to try to do something fun too. Thinking of treating myself to a movie. And that way when DH gets home we can just chill out the rest of the weekend! At least thats the game plan. Lets see if all my lofty ambitions work as planned.... Happy Saturday everyone!
Desiree -- what a GLORIOUS day that sounded like! hey...i think i have a new strategy for convincing DH to tack on a couple WDW days before our cruise DISboards research...tax deductible.... well i'm riding the roller coaster of good days and days i'm staying within my calories but poor food choices. it's been a stressful week...just alot of life things going on with extended family mostly i won't bore you with, and a teen DD last week i was struggling through a steroid wean and on day 5 i woke up in Adrenal Insufficiency, my first time to really have it since my surgery. honestly, i felt too awful to be scared; and thankful my DH had the good sense to work from home all day so i wasn't alone. If you're interested i'll elaborate...but mostly it's something i have to learn to be aware of and treat aggressively so that it doesn't lead to adrenal crisis (shock) and a trip to the ER. this time it didn't go that far, but it totally whipped me out for 3 days. ilterally friday i was in bed ALL day and slept through every episode of the Mentalist I attempted to watched. poor Patrick, he must be so disappointed in me so my attempt to go to a lower dose failed and i have to try again next week. I just took my 3 months post-op picture and i'm devastated b/c i don't look any different....in fact last week i gained 1.5 lbs. it's so impossible to stay motivated to make good healthy choices when my body doesn't respond! then i just got an email from my doc saying i needed to wait it out a couple more months before trying testosterone replacement. how in the world am i supposed to build muscle with testosterone below normal? i'm rambling...i'm frustrated....i need my WISH friends to cheer me on and keep me accountable. honestly if it wasn't for my new toy fitbit i'm sure i would've tossed in the towel for now. and you all
Aww I'm so sorry its been a rough couple of days. I'm gald your DH was able to stay with you. How scary! If you can't get out and do the exercising just maybe try to keep OP with your eating and tracking. And when you feel up to it maybe take a little walk. Just take things slowly and listen to your body and rest when you feel you need to. Don't give up! We are all in this together!!! This week has been a blur, I feel like I really haven't put in the exercise hours so I'm not very optimistic about what the scale will say tomorrow. Today after work I am going to the gym though. Starting W9D1 of C25K tonight after Sunday's big failure of a run (I tried to run without my compression stockings - bad bad bad idea!) so I only managed 12 minutes total exercise on Sunday and Saturday I skipped due to all the cleaning I did at the house. Which by the way, I didn't get much me time after all. I spent it all cleaning and organizing. Ugh. Still haven't touched our office (everything clutter gets trown in there so it's a huge mess) and I did not get to go to a movie either.
thanks ((desiree)) you are right and i am feeling a bit better today. i am going to the FC with my DD afterschool, our committment to each other, but i will not overdo it. and i'm tracking my food today. yesterday in my anxiety and not enough time to eat lunch, when i got home i ate total junk food and paid for it the rest of the day. my stomach felt awful...it's not worth it. i have to remember this! how's everyone else?? roll call? who's lurking??
I'm here! Sorry about the icky stomach! But glad you had a much better day the next day! I'm still trucking along. I have been pushing hard to make up some time with the exercise since I felt last week was a bust and I'm really hoping to (for once!) make goal for the DIS Exercise challenge. I did my next day of C25K today and then did 25 min on the elliptical. So it was a very good day at the gym. I sweated buckets but I suppose that's a good thing! I've read something somewhere that Sweat is the fat crying - lol. Is anyone else still around?
I'm here! I just had friends in town for the weekend, so of course a lot of eating happened... Ugh. I did exercise some good judgment, though: I limited my alcoholic beverage intake, adhered to GF eating, and didn't get popcorn at the movie (had a DQ Blizzard instead ) Anyway, today starts another week. I plan to get Jillianized five times this week, run twice, and spin twice. Who else?


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English » Church Unity »
Welcome to the Church Unity Section
"May they be all one, just as, Father, you are in me and I am in you, so that the world may believe it was you that sent me." (Jn 17: 21)
Orthodox! Catholics! Protestants! You all belong to Me! You are all One in My Eyes! I do not make any distinction...
My Vassula draw three iron bars with a head on the top
Message of October 27, 1987
A Cry from the Sacred Heart: Christ's Desire for Unity Vassula speaks to 500 pilgrims, including a Cardinal, Archbishops, Bishops and ecumenical clergy and laity of all faiths, on the teachings on Unity contained in the Messages of TLIG, at the Ecumenical Pilgrimage in Turkey May 25th 2007
Unity from the Heart Vassula delivers this powerful speech at the Holy Land Pilgrimage in 1998
The Dates of Easter Jesus calls us to unify the dates of Easter
An Example of Unity in the East Monsingor Isidore Battika shares with the TLIG Pilgrims an encouraging, real world example of unity being practiced in Syria
Ecumenism and Spirituality Ecumenical speech delivered by Vassula at the International Bridgetine Centre of Farfa
The Pope and Patriarch Theoctist Vassula witnesses this special meeting between Pope John Paul II and Patriarch Theoctist
A Spiritual Echo of Unity An Address given by Vassula Ryden to the Ecumenical Conference of the World Council of Churches
"Unity, Virtue of Love"This book of extracts from the Messages reveals to us how God is telling us, today, that unity among Christians is essential to bring peace, love and reconciliation into the world.
OneDate.org - Vote to Celebrate the Feast of Easter all in one date
TOP NEWS:10th True Life in God Ecumenical Pilgrimage in Italy October 10th-17th, 2015Exploring Sacred Destinations Stations of the CrossMeditations from True Life in God TLIG has a New Youtube ChannelSubscribe to the New TLIG Youtube Channel


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Jemimah Elizabeth Hogan
Jan 22, 2014
My Grandma, Jemimah Hogan, was known as 'Jerry' to her friends. She was born and grew up in Ocilla, Ga in 1894 and was related "to everyone in town" as she put it. After her father, Elijah J...
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Name: | David Wooten |
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William O J Bright and daughters
Feb 15, 2012
William Oliver James Bright was born William Oliver James Hymas, son of William J Hymas (ca1858-ca1913) and Sarah Olive Hymas, nee Bright (1872-1902). After his mother's untimely death, he was sent...


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Ito Misaki's Profile
伊東美咲 / いとう みさき / Anzai Tomoko (安斉智子)
伊東美咲 / いとう みさき / Anzai Tomoko (安斉智子)
Birth Place: Iwaki, Fukushima, Japan
Birth Date: 1977-05-26
Height: 171cms
Ito Misaki's Dramas & Movies:
Densha Otoko
Japanese DramaA true love story turned to bestselling novel, created from the Internet BBS, 2channel to blockbuster hit movie. Ito Misaki plays Aoyama Saori, working as an office lady at a… [More] -
Edison no Haha
Japanese DramaThe series focuses on Ayukawa Noriko, the teacher of a class of first-graders. One day, a boy named Kento transfers into her class from another school, where he was treated… [More] -
Itoshi Kimi E
Japanese DramaThe man she loves most is fated to lose his eyesight in three months. What would she like to show him most before he goes blind? And what would he… [More] -
Kiken Na Aneki
Japanese DramaIto Misaki stars as the number-one cabaret/hostess club girl. Hailing from the Miyazaki countryside, she has been told since her youth that all she has is a beautiful face. Her… [More] -
Lunch Queen
Japanese DramaNatsumi loves lunch. By chance she starts working for "Kitchen Macaroni", posing as the fiance of the owner's eldest son, Kenichiro. Kenichiro's father Kenzo and his three younger brothers -… [More] -
Taiho Shichauzo
Japanese DramaA marvelous team-play comedy with beautiful and active policewomen! Original story comes from a best selling comic book. Don't you want to meet with a woman who falls in love,… [More] -
Tiger & Dragon
Japanese DramaThe tale of Tiger & Dragon revolves around Rakugo, a traditional form of Japanese comedy that can look back on an impressive 400 year long history. Nagase portrays the Yakuza… [More] -
Yama Onna Kabe Onna
Japanese DramaMegumi is a top sales person at the handbag section of a department store. Many people admire, and sometimes even envy, Megumi for her beauty and outstanding skills to sell… [More]


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Discussion (7) ¬
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107 search results for Jericho
'Jericho' wins HitFix's first Uncanceled Showdown
Type: Post | Date: Thursday, Aug 28, 2014
The finale pit CBS' post-apocalyptic drama against 'Almost Human' -
Uncanceled Showdown Final 4: After thrashing 'Firefly' can 'Jericho' be stopped?
Type: Post | Date: Friday, Aug 22, 2014
'Deadwood,' 'Freaks & Geeks' and 'Almost Human' also make our semifinals -
CBS puts 'Wolf Lake,' 'Jericho' and 'Swingtown' online
Type: Article | Date: Tuesday, Jul 23, 2013
Skeet Ulrich, Mary Elizabeth Winstead and Jack Davenport duds hit CBS.com -
Uncanceled Showdown Round 2 pits 'Firefly' vs 'Terminator' and 'Deadwood' vs 'Rome'
Type: Post | Date: Friday, Aug 15, 2014
'Pushing Daisies' vs 'Jericho' makes for another tight matchup -
Robot Combat League
Type: Event | Date: Tuesday, Feb 26, 2013
It was what it sounds like and it starts tonight. -
Type: Event | Date: Tuesday, Jun 22, 2010
Watch prizes and family members fall off a building in this new show. -
'Jericho,' 'Heroes' veterans land HBO roles
Type: Article | Date: Tuesday, Mar 9, 2010
Dania Ramirez joins 'Entourage,' Lennie James joins 'Hung' -
'Jericho' co-star returns to CBS
Type: Article | Date: Friday, Feb 13, 2009
Lennie James is coming back to CBS -
Type: Article | Date: Wednesday, Mar 11, 2009
'Jericho' star returns in a new drama pilot that sounds mighty familiar


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[ Music Index | Metro | Metroactive Central | Archives ]
Boneheads in Berkeley
By Nicky Baxter
Onstage, the Goodfellas are cranking out the kind of artless leap-about clatter you'd expect from an opening act--just an all-American punk quintet having a little middle-finger fun. Eyeing the proceedings from Berkeley Square's elevated dining area, a beefy, leather-jacketed regular is conversing with a buddy.
"It's gonna be a great show, dude." Beefy nods vigorously in agreement, then adds, "Yeah, but when the boneheads get here, it's gonna get ugly."
He was right. And, of course, when the going gets ugly, the plug gets pulled. Which is what happened at Berkeley Square last Saturday, Dec. 7.
Funny how a few race-obsessed skinheads can ruin an evening of good, clean, violent fun. The bill coulda been a contender as one of Berkeley's finest smash-mouth punk marathons, featuring four bands guaranteed to bring the noise: Goodfellas, Oppressed Logic, Anti-heroes and headliners DI. Instead, what patrons got was the first act and maybe half of a second.
I arrived just as the Goodfellas opened fire. Something akin to a tea party had convened on the right side of the stage. About six or seven kids clad in the usual punk regalia perched beneath one of the Goodfellas' guitarists, chatting and giggling as if the stage's perimeter were a Telegraph Avenue cafe.
The Berkeley-based Goodfellas aren't bad; but they aren't all that good, either. The self-lacerating din of "I'm a Disgrace" is virtually indistinguishable from any of the other speedball shout-alongs the band bashes out. Still, they are a local band trying to make good, and the noise addicts eventually succumbed, sproinging up and down like Jiffy Pop.
Outside, a block-length queue of punkers inched its way past the ticket taker and security staff. As a matter of course, the show attracted a number of knuckleheads, some of whom happened to be skinheads.
But a distinction must be made between violence-prone bald boys (openly) advocating White Supremacy and S.H.A.R.P. skins (Skin Heads Against Racial Prejudice). To outsiders, it may be difficult to suss the difference (although blackfolk and other coloreds may get a clue pretty quickly); however, if you catch a skin "Zieg Heil-ing," there's a pretty good chance he or she dreams in white.
There are conflicting accounts of what triggered the commotion. Apparently, prior to a confrontation with the white anti-racists inside the club, a gang of White Nationalist punks from Sacramento had provoked the ire of several black youth. A scuffle ensued but was quickly squashed by club security.
(Curiously, one black security person later defended the White Nationalists, maintaining that they were "victimized by a bunch of young black gentlemen.")
Inexplicably, the decision was made to allow the "victims" into the club, at which point, said victims began taunting other patrons, throwing White Power signs and, according to security head David "Zeus" Reed, "using the N-word and verbally abusing anyone who disagreed with their clique."
Meanwhile, a string of police cars lined up outside the punk outpost in response to a call made by the club in connection to the racial fracas that had occurred earlier. Out of the blue, the Berkeley Fire Department arrived for an inspection.
Berkeley Square owner Omar Nashir explained later that when the fire department discovered that the club's "maximum capacity" sign was not properly posted, the party had to come to an end.
IDing DI
Backstage, interviewing DI's vocalist, Casey Royer, I missed all the action. During the course of his 14-year-career as the band's frontman, Royer has witnessed his share of racist skinhead violence.
The former Adolescent felt compelled to assure me that DIs have never been down with the White Power thing. He abhors that contingent of punkdom, "if [it], you know, tries to impose [its] beliefs on someone else. ... [But] everyone should be able to have their own opinions."
You may not find DI listed in Rolling Stone's supposedly all-inclusive encyclopedias, but these sons of the Sex Pistols are a quintessential punk troupe. "What separates us from other [punk] bands is our integrity and longevity," Royer said.
This was the band I'd driven nearly 60 miles to see. At 37, Casey Royer came off like the perennial class clown. He had a quip a minute--some coherent, some not so. "Punk is supposed to be fun," Royer told me. "It's not about hate or violence. It's about having a good time."
Someone ought to tell that to those boneheads from Sacramento.
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The beginners' course takes 8 weeks. You will be introduced to fencing with a foil (one of three weapons used in modern Olympic fencing). You will learn how to be safe with yourself and others, learn footwork, blade technique, hand / eye and foot co-ordination and some of the rules and regulations of the game. You will improve your reaction times, your mental and physical stamina and firm up tummy and thigh muscles as well as those you sit upon! The course costs £60.00 per person (£45.00 for Juniors) and includes two free sessions of club fencing to make a total of ten weeks to develop your skills. It doesn't matter how old you are and it doesn't matter how fit you are. The beauty of fencing is that everyone can participate to their own level of satisfaction and ability and still get something out of it. Instruction is from England Fencing coaches who are members of the British Fencing Association, qualified and insured to teach. Beginners are provided with all of the basic kit required to learn to fence safely. By the end of the 8 weeks you should be at the equivalent standard of British Fencing's Proficiency Grade 1. If you enjoy the course and wish to continue fencing, then you can join Radcliffe Sword Club. We would be happy to welcome you whether you are interested in taking your skills further to competition at local, regional and national level or just in participating in a weekly social activity in a friendly environment that keeps you fit! If you do decide to continue after the beginners' course you will probably want to purchase your own kit. There are members at the club who can advise on the best options and can assist in obtaining prices with club discount. Those who continue and want to learn to fence at sabre and/or epée (the other Olympic fencing weapons) will be able to do so under the instruction of our experienced coaches.
To see fencing in action take a look at the video posts on the Links page
Beginners Class Dates
The next Beginners Courses will start on:- Juniors: 18:30-20:00 Tuesday 28th April 2015. Adults: 20:00-22:00 Tuesday 28th April 2015. Courses are limited to 16, so please book early!
For an enrolment form for the adults' course please click here. For the Junior club, please click here.
For more information regarding beginners' courses please click here to send an email, or phone Chris Wood on 07940-651556. For any other queries, please click here.


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Word problems involving probability models often ask you to decide about whether an experiment is likely to turn out to your advantage or not.
A local club plans to invest $10000 to host a baseball game. They expect to sell tickets worth $15000. But if it rains on the day of game, they won't sell any tickets and the club will loose all the money invested. If the weather forecast for the day of game is 20% possibility of rain, is this a good investment?
Make a table of probability distribution.
Use the weighted average formula.
The club can expect a return of $2000. So, it's a good investment, though a bit risky.
In other cases, we are asked to find the values of one or more variables involved in the model for which the experiment has a given expected value.
A company makes electronic gadgets. One out of every 50 gadgets is faulty, but the company doesn't know which ones are faulty until a buyer complains. Suppose the company makes a $3 profit on the sale of any working gadget, but suffers a loss of $80 for every faulty gadget because they have to repair the unit. Check whether the company can expect a profit in the long term.
Write the probability distribution.
Since the expected value is positive, the company can expect to make a profit. On average, they make a profit of $1.34 per gadget produced.


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Ardentryst is an action/RPG sidescoller, focused not just on
fighting, but on story, and character development. It features
two playable characters and a variety of weapons, items, armour,
monsters, and beautiful level scenery and graphics.
License | Verified by | Verified on | Notes |
Creative Commons Attribution Share-Alike 2.5 | Debian | 20 March 2013 | |
GPLv3orlater | Debian | 20 March 2013 | |
Other | Debian | 20 March 2013 |
Leaders and contributors
Resources and communication
Audience | Resource type | URI |
Download | http://jordan.trudgett.com/ |
Software prerequisites
Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the page "GNU Free Documentation License".
The copyright and license notices on this page only apply to the text on this page. Any software or copyright-licenses or other similar notices described in this text has its own copyright notice and license, which can usually be found in the distribution or license text itself.


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Pinquito Beans? Lompoc?
Nov 28, 2005 by Bean Counter in California
Feb. 2013 Dish of the Month - CHILE RELLENO
Jan 31, 2013 by DiningDiva in San Diego
Talk me out of it- marble countertops
Feb 12, 2010 by mjhals in Cookware
San Diego New Places Opening Thread, Part Deux
Sep 16, 2011 by Fake Name in San Diego
If you love Mexican Seafood check this out
May 03, 2012 by LarryP in San Diego
Are there no good eats in Ventura County?
Mar 22, 2006 by tenom dude in Los Angeles Area
Kitchen 4140
Jun 09, 2012 by phee in San Diego
Los Olivos - Solvang - Santa Ynez
Aug 21, 2012 by pickypicky in California
Favorite (independent) coffee shop?
Feb 12, 2013 by ipsedixit in San Diego
El Molino Central, Sonoma
May 31, 2010 by davina in San Francisco Bay Area
New, Tasty ! Fredericksburg - Doss - Mason - Harper
Jun 30, 2012 by pickypicky in Texas
The Pony Room...Rancho Valencia Resort
Jan 18, 2013 by Beach Chick in San Diego
Question for san diegans - what is the state of the food "scene" right now?
Sep 29, 2008 by tastycakes in San Diego
Italian Wine 101 for French Wine Lover?
Nov 02, 2010 by Klunco in Wine
Things I ate/drank in college that I will never eat again
Aug 18, 2008 by rHairing in General Topics
Best SD doughnut / donut ?
Nov 26, 2012 by pickypicky in San Diego
THE ART OF EATING and TX Barbecue
Jan 15, 2012 by pickypicky in Austin
Puesto in LJ
Jan 03, 2012 by bizzwriter in San Diego
Dive Bars..San Diego
Aug 22, 2008 by Beach Chick in San Diego
Where are some of your favorite places to have lunch in SD?
Apr 16, 2010 by Beach Chick in San Diego
Delicias - 9-Course Tasting Menu or Keeping up with Chef McCabe
Oct 23, 2012 by honkman in San Diego
Table 926
Jan 15, 2012 by pickypicky in San Diego
San Diego CLOSED Restaurants - Replacement for old board.
Sep 27, 2010 by mjsp1 in San Diego
Sep 25, 2012 by notjustastomach in San Diego
Locally produced Ginger Ale in San Diego?
Jan 31, 2013 by ipsedixit in San Diego
anywhere I am
Best meal I ever ate:
Le Manoir aux Quat' Saisons , UK and Cochineal, Marfa TX
My most tattered cookbooks:
Chez Panisse Menu Cookbook, Marcella Hazan, Diana Kennedy, Art of French Cooking
People Reading Me


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I dig the quirky packaging of these solid stick perfumes by Crazylibellule and the Poppies, $16 each.
August 11, 2009
I Got Yo' Crazy
Published in: Daily Beauty
So far, 8 people have commented on this article. How cool is that?
I have a couple of these. They are very good for a subtle scent when I am in the hospital.
So cute! The last one looks like fun! Will you be describing the fragrances later? If so, looking forward to it. =)
.-= Catherine's last blog post… Sunscreen Series, For Face: DDF Organic Sun Protection =-. -
I purchased one of these for my daughter for her bday…and of course tried it later after she had opened/tried it herself. The scents are lovely imo, we got the blue one and it is soft, feminine, and floral…BUT I dont like the residue it leaves on my skin. It it a bit oily, which is no problem with perfumes as that adds staying power, but this product leaves a waxy/oily residue that just sits on the skin and then pills up a bit with time. Yuck.
I love mine! I've had the Vanilla Fruit Sorbet one for a couple months and its still going strong. I get migraines and most fragrances are way too much for me when I'm hurting, so this light touch is perfect. Plus its travel friendly! Yes, it does get a bit of residue, but I usually put a bit between the twins twice a day so it doesn't bother me.
.-= Trude's last blog post… Dad's Birthday =-. -
I have never even heard of these! Time to do some beauty exploration!
.-= Kajal Couture's last blog post… Urban Decay Friends and Family 30% Off!!! =-. -
Oh! How do you like these? I've wanted to try Louise, Josephine, and Gabrielle. Will you be reviewing them?
.-= Alexzandra's last blog post… This Week's Sales =-. -
They are very cute! I like that they're "happily" made in France, he he
.-= Marce's last blog post… Korres Cherry Full Colour Gloss – Review =-. -
Those are cool! My apt's color scheme matches Jeanne Voyage. Where can I find these locally?
.-= Marisol's last blog post… I heart Shu Uemura =-.


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Donna Karan | Charlotte Tilbury
Inspiration: "The look is inspired by 1930's photographs – sepia tone shading but with a slick gloss on the eyes to make it modern."
Eyes: Dusk cream colour base – blended through crease, over lids and along lower lash line to create shading and depth. Copper Walnut PRO Gloss mixed with a bit of Reflects Gold – applied from lid to brow for a wet look on the eyes.
Face: Fast Play lipstick – blended onto the apples of the cheeks. Pearl cream colour base – swept over cheek bone, bridge of nose, and bow of lips to highlight.
Lips: Half and half lipstick – lightly patted onto the lips.
See breakdowns from Caroline Herrera and Luca Luca… Continue reading →


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UFO Sighting
Have a question or comment about this sighting? Join our open discussion and let us know what you think.
Sighting Basics
Case Number | 58205 |
Log Number | IE-07202014-0019 |
Date Submitted | 07/20/2014 06:20 UTC |
Date of the Event | 02/10/1979 07:02 UTC |
Source | MUFON |
Disposition | Unresolved |
Summary | in orbit and one light looking as if checking out other craft |
Tags | lights |
Sighting Location
City | Limerick |
Region | Limerick |
Country | Ireland |
Latitude | 52.67339 |
Longitude | -8.621338 |
The latitude and longitude presented here is an approximation to protect the reporters identity
Sighting Specifics
Viewing Distance | N/A |
Sighting Duration | Undisclosed |
Object Features | None |
Object Flight Path | Straight-line path |
Object Shape | Disc |
Weather Factors | Unknown |
Sighting Details
I was going to work and the sky was bright nd clear.I saw 6 lights in a line and one light looked as if itb was cheking over the other ones.the direction was NE.no noise at all,and definately in earth orbit. |
Did You See It? Have a Comment or Question? Discuss it Below.
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Return to the Map
The location presented here is an approximation to protect the reporters identity
Sighting Trends for Limerick
- There has been one other sighting in Limerick
- There were no other sightings in Limerick on or around February 10th 1979
- This sighting has never been favorited.
Images and Videos
No Images or Videos Provided


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Action timelineDecember 28, 2011 – The Center and two Arizona herpetologists submitted a status report to the U.S. Fish and Wildlife Service establishing the need for Endangered Species Act protection for the narrow-headed garter snake. July 7, 2014 – According to our 757 species settlement, the Service finalized protection for the Southwest's narrow-headed garter snake as well as the northern Mexican garter snake. |
Photo courtesy of New Mexico Department of Fish and Game | HOME / DONATE NOW / SIGN UP FOR E-NETWORK / CONTACT US / PHOTO USE / |


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- James Walker, ESPN Miami Dolphins reporterClose
- A Temple graduate and Hyattsville, Md., native who lives in Miami
- Joined ESPN in 2008
- 0 Shares
- Comment
MIAMI – The Miami Dolphins completed their fifth and final preseason game Thursday night with a 24-21 victory over the New Orleans Saints. This game was played mostly by backups on both sides.
Earlier this week, I mapped out three things to watch from Miami's perspective. Here is a recap of how the team fared in those areas:
1. Players on the bubble: Much of Miami's roster is set. But this was a big game for those toward the back end. The biggest bubble player was third-string quarterback Pat Devlin. He showed some good and some bad with 259 yards, two touchdowns and two interceptions. The Dolphins must decide if it's worth keeping three signal-callers or use that extra spot on another position. Bubble players with better showings Thursday were defensive lineman Vaughn Martin (four tackles, a half-sack) and safety Kelcie McCray (four tackles) and wide receiver Marvin McNutt (four receptions, 99 yards). This trio may have done enough to claim three of Miami's final roster spots.
2. Progression of tight ends: Miami is still in search of its best option at tight end after losing starter Dustin Keller (knee) for the season. Projected starter Charles Clay was inactive. But Dion Sims stepped up, grabbing four balls for 36 yards and a touchdown. Second-year tight end Michael Engew also got a lot of playing time but didn't produce, to the tune of one reception for 5 yards. Sims is raw, but he has a good chance to contribute if he gains experience.
3. No injuries: Dolphins head coach Joe Philbin played it as safe as possible in this one. He sat every starter with the exception of right guard John Jerry, who needed the work. As a result, Miami walked out of the fifth preseason game with no significant injuries to its starting lineup. Barring any setbacks next week in practice, the Dolphins should enter their Sept. 8 regular-season opener against the Cleveland Browns in good health.
What to watch revisited: Miami Dolphins
MIAMI – The Miami Dolphins completed their fifth and final preseason game Thursday night with a 24-21 victory over the New Orleans Saints. This game was played mostly by backups on both sides.


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A lightweight fight between Daron Cruickshank and James Krause has joined July's UFC on FOX 16 lineup.Filed under: MMA Rumors, News, UFC read news >>
A lightweight bout between Kevin Lee and James Moontasri has joined July's UFC Fight Night 71 lineup.Filed under: MMA Rumors, News, UFC read news >>
There's an interesting lightweight showdown in the form of Joe Lauzon vs. Takanori Gomi coming to the UFC on FOX 16: "Dillashaw vs. Barao 2" mixed martial arts (MMA) event, scheduled for Sat., July 2 read news >>
Takanori Gomi and Joe Lauzon will face off in a lightweight contest at UFC on Fox 16, according to a Thursday report from MMAJunkie.com. It will be hard punches and sharp submission attempts as two o read news >>
UFC lightweight John Makdessi generally has good luck when he fights in his native Canada – but that doesn't mean it's a stress-free experience.Filed under: News, UFC read news >>
A lightweight bout between former PRIDE champion Takanori Gomi (35-10, 1 NC) and all-time post-fight bonus winner Joe Lauzon (24-10) has been added to the UFC on Fox 16 fight card. read news >>
A scrap between entertaining lightweight veterans is the latest addition to UFC on FOX 16, as Joe Lauzon and former Pride champion Takanori Gomi have agreed to dance on the July 25 card. The UFC anno read news >>
A lightweight contest between Japanese superstar Takanori Gomi and "Fight Night" bonus machine Joe Lauzon has been added to UFC on FOX 16.Filed under: News, UFC read news >>
On Wednesday, UFC confirmed two new lightweight bouts have been added to the UFC on Fox 16 event on July 25 in Chicago. read news >>
Freshly crowned lightweight champ Rafael dos Anjos is rooting for Khabib Nurmagomedov to beat Donald Cerrone at UFC 187. Rafael dos Anjos has unfinished business with Khabib Nurmagomedov. The two sur read news >>
Another lightweight tilt has made its way onto the latest UFC on FOX card to hit Chicago.Filed under: News, UFC read news >>
In terms of the famous poem by Robert Frost, the current UFC lightweight contender is a firm subscriber to taking the path less traveled by. His reasons for doing so are not to be adverse by nature, read news >>
WSOF lightweight Nick Newell is nine months removed from an unsuccessful bid for the title, which ended via second-round TKO when champ Justin Gaethje overwhelmed him with strikes. But he wants anoth read news >>
UFC lightweight champion Rafael dos Anjos underwent surgery on Thursday, and everything went fine. dos Anjos, who defeated Anthony Pettis at UFC 185 to become the first Brazilian to win the UFC 155-p read news >>


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S. 2068 (113th): Handgun Trigger Safety Act of 2014
- Introduced:
Feb 27, 2014
113th Congress, 2013–2015- Status:
Died in a previous Congress
This bill was introduced on February 27, 2014, in a previous session of Congress, but was not enacted.
- Sponsor:
Edward "Ed" Markey
Senator from Massachusetts
Democrat - Text:
Read Text »
Last Updated: Feb 27, 2014
Length: 15 pages
About the bill
- Full Title
A bill to provide for the development and use of technology for personalized handguns, to require that, within 3 years, all handguns manufactured or sold in, or imported into, the United States incorporate such technology, and for other purposes.
Legislative action may be ocurring on one of these bills in lieu of or in parallel to action on this bill.
- What is a bill?
The "S." in "S. 2068" means this is a Senate bill in the United States Congress. A bill must be passed by both the House and Senate in identical form and then be signed by the President to become law.
The bill's title was written by its sponsor.
- Cosponsors
2 cosponsors (2D) (show)
- Committee Assignments
The committee chair determines whether a bill will move past the committee stage.
- Votes
There have been no votes related to this bill.
- Subject Areas
- Find Similar Bills
Search for similar bills.
Links & tools
- Primary Source
THOMAS.gov (The Library of Congress)
GovTrack gets most information from THOMAS, which is updated generally one day after events occur. Activity since the last update may not be reflected here. Data comes via the congress project.
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�Hello Catherine, Ron and family, Winter is gone, and I am so anxious to get back to your campground. We have been to many and yours is the nicest we have seen. It is incredible...people tubing that river, it is so beautiful. Me, being a non swimmer and terrified of water, I was even talked into doing a tube run and I loved it and can hardly wait to do it again. The park is so clean and so peaceful. Sitting under the awning with a coffee in the morning or around the campfire at night, it's like the rest of the world doesn't exist. And on top of all that, there is the warm and friendly greetings from you and your lovely family and - Charlie. As far as we are concerned, this is the only campground for us. Thank you for making each outing memorable. Fran, Dennis & Lacey (dog) from Gilford, ON
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Saugeen Springs R.V. Park presently has several large sites (approx 50' x 100')
to accommodate these large park units.
Click on our Dealer Links below for more information


text:
This article details a real world example of using a Model-View-ViewModel Design Pattern. I split the development process into steps. Each step is based on the previous one and adds some specific functionality. At the end of each step, we will have a working application.
As an example I chose Twitter Client. I hope that this application is comprehensible and useful. I'll use TweetSharp library to make work with twitter API simple and not cumbersome.
The reader is supposed to have some experience of work with WPF, in particular, having investigated data binding.
I will not write here why you should use MVVM while working with WPF. Yet if you want to read in details about the motivation for using this design pattern, I would recommend you to read "WPF Apps with the Model-View-ViewModel Design Pattern" by Josh Smith. On my part, I would like to say that the design which smells is a big pain, especially if you use WPF.
You also may download a bit more developed twitter client on github: https://github.com/KirillLykov/AnhingaTwitterClient
A Twitter Client shows tweets grouped according to some criterias. It also allows submitting tweets and sends direct messages. Finally, it provides friends management – a user can "follow" somebody what means he or she will see the followings tweets in his or her tweetlist.
We start off with looking at an existing Twitter Client before writing code. This analysis will clarify how our client should look and what controls we should use.
There are several bookmarks at the top of the window - recent, replies, user, etc. Depending on the chosen bookmark, the different information is displayed in the main part of the window. For instance, if the recent bookmark has been chosen, there will be the list of the last tweets. If the messages bookmark has been chosen, there are direct messages.
This short analysis leads to the solution to use TabControl. It will display the pages with various contents and show the name of the chosen TabItem at the Top.
First, I want to describe the situation when a developer tries to create an application using WPF but without using MVVM. It'll provide the starting point and demonstrate benefits of using MVVM in a real- life example.
Imagine you need to write a UserControl that displays tweets. Imagine also that you decided not to learn MVVM and prefer to do everything the same way, you would do it if you used a framework of the previous generation, like WinForms. Perhaps, you will press "Add UserControl" in VS, and then add controls you need in XAML. After that, you will add to the code behind a property which will store tweets. Finally, you will add to the code behind methods which will handle events like button mouse click, etc. At the end, you will have some XAML code which describes graphical design and code behind which stores data and contains events handlers.
Let us have the first feature request– users need to see some other tweets, not those you store in your property. But they are ok with the design of your control. Perhaps, you will sort it out by adding a flag in your code behind. If it is true, than you show those tweets that you showed them one group tweet, otherwise another one. Not a great solution, but it works.
Time passed and you've got the second feature request – some users think that every tweet contains too much redundant information. Thus, you should create a new look of tweets. At the same time, you don't want to offend those users who like the old look… You definitely will create some sophisticated solution for this problem but it is not the last feature request you will get. And the more you get, the more difficult it is to solve them…
The question is whether it is possible to design the application in the way which allows avoiding copy-paste and simplifying the code. What if we move the code behind user control to a separate class? In this case, we will have one class inherited from UserControl which represents the user interface. Call it View. And another class represents data directly connected with View, e.g., those data and event handlers which might be in code behind. Call it ViewModel.
This differentiation into View and ViewModel would easily solve the first feature request. We needed to display the new group of tweets in the same way as the first one. All the developer would need is to create a new ViewModel class which contains the new data and map it into the View he or she already have.
The second feature request could be solved by writing a new View and using the old ViewModel.
The only question is how to create this mapping between View and ViewModel. The data binding is the tool which will provide this mapping. Imagine we have a View and a ViewModel which know nothing about one another. In the third class (I will call it Main View), where we are going to use View, we will set up the right DataContext for our View. It will not cause any changes in the code of View or ViewModel. I deliberately skip the technical details. I will describe them in the following paragraphs.
If you like the UML class diagram, here we have one describing the typical application written with MVVM:
We see View classes which use data from ViewModel classes. It is essential that View classes know nothing about Model. The Model encapsulates all business logic and provides data for ViewModel. ViewModel organizes data the way suitable for View. ViewModel knows nothing about Views use it.
We also have a special View and ViewModel classes I called "Main". The Main View is not a widespread term, but I introduced it in order to simplify the description of the MVVM. It is the main UserControl which displays all others. It sets up data context for the View classes it uses. The Main ViewModel contains all ViewModels for particular UserControls.
Start with creating the application with TabControl containing only one tabItem. Call it "Recent".
Create a new WPF application and add TabControl in the MainWindow:
<TabControl Height="400" HorizontalAlignment="Left" Name="Tabs" VerticalAlignment="Top" Width="300"> <TabItem Header="Recent" Name="RecentTab"/> </TabControl>
The MainWindow is the Main View in our application. It will contain all other Views which will be represented in the TabItems. It must have an appropriate Main ViewModel. Call it SimpleTwitterClientViewModel. It will contain necessary data and methods which handle the events like mouse button click. Point out that the Main View must get data from the Main ViewModel (by default, it gets them from the code behind). What we should do is to set up the DataContext:
<Window x:Class="SimpleTwitterClient.MainWindow" x:Name="MainWindowInstance" xmlns:view="clr-namespace:SimpleTwitterClient.View" xmlns:viewModel="clr-namespace:SimpleTwitterClient.ViewModel" DataContext="{BindingViewModel,ElementName=MainWindowInstance}">
public partial class MainWindow : Window { private SimpleTwitterClientViewModel _viewModel; public SimpleTwitterClientViewModel ViewModel { get { return _viewModel; } set { _viewModel = value; } } public MainWindow() { _viewModel = new SimpleTwitterClientViewModel(); InitializeComponent(); } }
Create a new UserControl, call it RecentView, and add a button to it. Create also a new class RecentViewModel.
SimpleTwitterClientViewModel is to hold ViewModels for all TabItems in the TabControl. Right now, we have only "Recent" so write the following code:
public class SimpleTwitterClientViewModel { RecentViewModel _recentPage = new RecentViewModel(); public RecentViewModel RecentPage { get { return _recentPage; } set { _recentPage = value; } } }
Get our TabItem to display RecentView. First, set up the Content of the TabItem into the RecentPage:
<TabItem Header="Recent" Name="RecentTab" Content="{Binding Path=RecentPage}"/>
Second, create a mapping between RecentView and RecentViewModel:
<Window.Resources> <DataTemplateDataType="{x:TypeviewModel:RecentViewModel}"> <view:RecentView /> </DataTemplate> </Window.Resources>
After all these manipulations, we will have the application like the following:
At this point, the applying of MVVM may seem a bit cumbersome but at the following steps, you will appreciate the merits of MVVM.
The Twitter API uses the OAuth 1.0 protocol. In order to use an application with the Twitter API, we have to write some code which will perform the necessary authorization steps. If you are not interested in the detailed description of this code, you skip the text below but get the class called OAuthHandler from the enclosed code and use it. it is a simple singleton which does all the authorization work.
FluentTwitter.SetClientInfo( new TwitterClientInfo { ConsumerKey = Settings.Default.ConsumerKey, ConsumerSecret = Settings.Default.ConsumerSecret }); var twit = FluentTwitter.CreateRequest().Authentication.GetRequestToken(); var response = twit.Request(); var RequestToken = response.AsToken(); twit = twit.Authentication.AuthorizeDesktop(RequestToken.Token);
The last line of this code will open the default browser. After clicking "Allow" at the appeared page, you will see the PIN. You need it in your application so create a dialog which asks the PIN from the user. I call this dialog in the method getPinFromUser:
string verifier = getPinFromUser();
twit.Authentication.GetAccessToken(RequestToken.Token, verifier); var response2 = twit.Request();
new AccessToken
Fill in the RecentPage by the real data, i.e. the last tweets posted by the user's followings and the user's own tweets. In order to do that, we will use TweetSharp library. Add it to the list of references for your project.
Before starting, add the classes OAuthHandler and AskPinFromUserDialog from enclosed code to the Model folder. Add ConsumerKey, ConsumerSecret, OauthInfoFileName to settings. OauthInfoFileName contains the path to the config file where we store AccessToken. Perhaps, it is not the greatest solution but it is simple and works. Finally, add the creation of the OAuthHandler to the Main ViewModel:
Model.OAuthHandler _oauthHandler = newModel.OAuthHandler();
Now, we can start working with RecentPage. First, add the container which will hold tweets to the RecentViewModel:
public ObservableCollection<TwitterStatus> Tweets { get; set; }
We used ObservableCollection instead of regular .NET container like List because ObservableCollection synchronizes the data with the View automatically, i.e., we needn't wait for event "data changed" in order to refresh View.
Now, download tweets. First, create a constructor for the RecentViewModel which gets the OAuthHandler as the parameter and save it into the _oauthHandler field. After that, add the LoadTweets method:
public void LoadTweets() { TwitterResult response = FluentTwitter .CreateRequest() .AuthenticateWith( Settings.Default.ConsumerKey, Settings.Default.ConsumerSecret, Model.OAuthHandler.Token, Model.OAuthHandler.TokenSecret) .Statuses() .OnHomeTimeline().AsJson().Request()); var statuses = response.AsStatuses(); foreach (TwitterStatus status in statuses) { Tweets.Add(status); } }
For the first time, call LoadTweet right in the constructor of RecentViewModel:
public RecentViewModel(Model.OAuthHandleroauthHandler) { _oauthHandler = oauthHandler; Tweets = newObservableCollection<TwitterStatus>(); LoadTweets(); }
Then create ListBox which will display tweets:
<ListBoxx:Name="RecentTweetList" ItemsSource="{Binding Path=Tweets}" IsSynchronizedWithCurrentItem="True"/>
If you execute the application now, you will see the list with the result of invoking method TweetStatus.ToString(). It is because the elements of the ListBox don't know how to display the objects of type TweetSharp. In order to do that, we need to add a DataTemplate to the UserControl.Resources.DataTemplate should contain the XAML code which determines the look of tweet. It should contain textbox for the text of the tweet, image for the userpic and so on. For every element like this one, we need to write binding to the appropriate property of the TweetSharp type object:
<DataTemplate x:Key="TweetItemTemplate"> <Grid x:Name="TTGrid"> <Grid.RowDefinitions> <RowDefinition Height="5*" /> <RowDefinition Height="2*" /> </Grid.RowDefinitions> <Grid.ColumnDefinitions> <ColumnDefinition Width="5*" /> <ColumnDefinition Width="3*" /> <ColumnDefinition Width="17*" /> </Grid.ColumnDefinitions> <Image Source="{Binding Path=User.ProfileImageUrl}" Name="UserAvatarImage" /> <TextBlock Name="ScreenNameTextBlock" Text="{Binding Path=User.ScreenName}" Grid.Row="1"Grid.ColumnSpan="2"/> <TextBlock Text="{Binding Path=Text}" TextWrapping="Wrap"Grid.Column="1"Grid.ColumnSpan="2" /> </Grid> </DataTemplate>
Finally, point that the ListBox must use this DataTemplate:
Launch the application. It should look like that:
In this paragraph, we create an additional page which contains retweets.
The recent bookmark displays the last tweets being written by user's followings or by the user him / her self. The method which downloads this group of tweet called HomeTimeline in TweetSharp. Yet it is not the only group of tweets that might be desirable for the user and in the class TwitterStatusesExtensions you may find methods that download other groups of tweets: OnFriendsTimeline, OnListTimeline, RetweetedByMe…
For instance, we'll choose all retweets posted by your friends. In order to do that, we should create class RetweetsViewModel which is to store all tweets obtained by RetweetedToMe() method. I'll not write this code here, let it be a simple exercise. Note you don't need to code a RetweetsView class. I will explain why at the end of the paragraph.
What we need to do now is to add the RetweetsViewModel object to the main ViewModel. Actually, we can do that by adding the new property for it and in the case of two pages, it's ok. Yet imagine that we want to deal with many pages in TabControl. In this case, it makes sense to store pages in some container.
The RecentViewModel is very similar to the RetweetsViewModel. We can extract an interface IPageBase from the RecentViewModel and make the RetweetsViewModel class implement it. We also may make both of them have default constructors by a property:
public interface IPageBase { void LoadTweets(); ObservableCollection<TwitterStatus> Tweets { get; set; } }
Now, the time to change the code of the main ViewModel comes:
ObservableCollection<IPageBase> _pages; public ObservableCollection<IPageBase> Pages { get { return _pages; } set { _pages = value; } } public SimpleTwitterClientViewModel() { _pages = new ObservableCollection<IPageBase>(); _pages.Add(new RecentViewModel()); _pages.Add(new RetweetsViewModel()); foreach (var page in _pages) { page.LoadTweets(); } }
Finally, we shall add the new DataTemplate for the RetweetsPage in the Main View. Ok, there we get a problem. Before we have had only one TabItem which was bound to the property RecentPage in the Main ViewModel:
<TabItem Header="Recent" Name="RecentTab" Content="{Binding Path=RecentPage}" />
Now we can't be satisfied with such a solution because we need to have as many TabItems as the amount of pages there are. Fortunately, there is a smart property ItemsSource in the TabControl class so we can just bind your container to it.
Yet there is an issue. A TabItem has a Header which displays the name of the page but if our TabItems has been automatically generated by the ObservableCollection, it is not clear how to set TabItems headers. Don't panic, first, add Name property to the IPageBase interface and implement it in every page class. Then create a style for the TabItem's Header:
<TabControlName="Tabs" ItemsSource="{Binding Pages}"> <TabControl.ItemContainerStyle> <Style TargetType="TabItem"> <Setter Property="Header" Value="{Binding Name}"/> </Style> </TabControl.ItemContainerStyle> </TabControl>
At the end, we will add View for our RetweetsViewModel. Of course, you may create a RetweetsView UserControl by copy-pasting code from the FriendsView. But there is a better solution. You may use RecentView as is:
RetweetsView UserControl
<DataTemplateDataType="{x:TypeviewModel:RetweetsViewModel}"> <view:RecentView /> </DataTemplate>
Finally, rename RecentView to TweetsView. That's all. Now, our application should look like that:
If you don't like writing two similar DataTemplates, you might create a superclass for these ViewModels and specify only one DataTemplate for this superclass.
As an exercise, you may implement View and ViewModel for the list of user's followings and followers.
Once previous 3 steps are completed, a user gets an application which allows reading tweets. But user still can't send tweets. In this paragraph, I will describe how to implement this feature according to MVVM.
Add TextBox and Button at the bottom of the Main View:
The main question of this paragraph is how to handle events raised by control elements in the View. If you liked to have Send button click event handler in the code behind, you would click on this button right in the designer and would write code in the created function in the code behind. So far as we use MVVM, the method that handles the event must be handled in the Main ViewModel. It leads to a bit more tricky code.
Main ViewModel
First, add the Message property to the Main ViewModel. Then bind your tweet textbox to Message property:
<TextBoxName="EnterTweetTextBox" Text="{BindingMessage}"/>
Write a method which will send tweet:
private void SendTweet() { var twitter = FluentTwitter.CreateRequest(); twitter.AuthenticateWith( Settings.Default.ConsumerKey, Settings.Default.ConsumerSecret, OAuthHandler.Token, OAuthHandler.TokenSecret); twitter.Statuses().Update(Message); var response = twitter.Request(); //you can verify the response here }
There is only one problem to solve – how to specify that SendTweet method should be called when the Send button is clicked. The Button class has a relevant property Command. It specifies the method which invokes when the button is pressed. Great, but Command has a type ICommand, while your SendMessage, of course, is just a function and it can't implement this interface. The convenient solution is to use Adapter pattern from the "Design Patterns" book. It is easy but we don't need to write this adapter because it has been already written by Josh Smith.
internal class RelayCommand : ICommand { #region Fields readonly Action _execute; readonly Func<bool> _canExecute; #endregion #region Constructors public RelayCommand(Action execute) : this(execute, null) { } public RelayCommand(Action execute, Func<bool> canExecute) { if (execute == null) throw new ArgumentNullException("execute"); _execute = execute; _canExecute = canExecute; } #endregion // Constructors #region ICommand Members [DebuggerStepThrough] public bool CanExecute(object parameter) { return _canExecute == null ? true : _canExecute(); } public event EventHandler CanExecuteChanged { add { if (_canExecute != null) CommandManager.RequerySuggested += value; } remove { if (_canExecute != null) CommandManager.RequerySuggested -= value; } } public void Execute(object parameter) { _execute(); } #endregion // ICommand Members }
Class RelayCommand just adapts delegate to the interface ICommand. To use it in the code, you need to create a property which wraps the SendTweet with ICommand:
RelayCommand _sendCommand; public ICommand SendCommand { get { if (_sendCommand == null) { _sendCommand = new RelayCommand(() => this.SendTweet()); } return _sendCommand; } }
Finally, let we make SendButton to use SendCommand as it's handler:
<Button Name="SendTweetButton" Command="{Binding SendCommand}"/>
Not really tricky, isn't it? That's how the tweeter client looks like now:
In order to make it look like the existing twitter clients, I added a stylistic effect. The textbox displays how many symbols user may enter.
As an exercise, you may implement the following feature. If user clicks on the userpic, the TabItem will be changed. It will display only tweets posted by this following.
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Linda Ronstadt Says She Can't Sing Anymore
Because of Parkinson's disease.
READ MORE »Because of Parkinson's disease.
READ MORE »According to TMZ.
READ MORE »The police are looking into the charges.
READ MORE »She was 43.
READ MORE »And she's postponing her tour.
READ MORE »Sad.
READ MORE »The cause of 36-year-old Sage Stallone's death is unknown so far.
READ MORE »Sad.
And now Frances Bean controls it.
Although it's unconfirmed.
READ MORE »It might make your heart hurt.
READ MORE »"We don't know how he's going to be," says his friend Jim Norton.
READ MORE »Daniel Radcliffe made the announcement.
READ MORE »He suffered a stroke last week.
READ MORE »We can't watch slow loris videos anymore.
READ MORE »This is sad.
READ MORE »See the video, and his giant Christmas tree.
READ MORE »Sad things.
READ MORE »"When I got into this business, I didn't think I'd be having to downsize 20 years later because it's screwed up. I just wanted to stand in the back of a hall watching the Clash."
READ MORE »Three months after Alex Chilton's passing.


text: FOR IMMEDIATE RELEASE: CONTACT: Peter Van Delft SUFFOLK COUNTY SHERIFF'S DEPARTMENT RELEASES SUMMER EDITION OF "COMMON GROUND"The Suffolk County Sheriff's Department recently released the summer edition of its Common Ground newsletter. Created by Sheriff Andrea J. Cabral, the Common Ground newsletter derives its name from the spirit of partnership within the Department and between the Department and the communities of Suffolk County, educating and informing the general public about the work that members of the Department do within its facilities – the Suffolk County House of Correction, the Nashua Street Jail and the Chelsea Officer Training Academy. While providing a monthly accounting of the many programs, activities and functions of the Department and the accomplishments of its employees, the Common Ground also highlights the Department's numerous public health and safety outreach initiatives throughout Suffolk County's Winthrop, Revere, Chelsea and Boston neighborhoods. The Summer 2011 issue of Common Ground features article topics that include: Sheriff Cabral's support of Transgender Rights Bill H.502/S.764; the graduation of 25 new officers from the Department's Correction Officer Training Academy; law enforcement careers at the Department; public safety training conferences held by the Department in partnership with the Massachusetts Sheriff's Association; the Department's ongoing support of the Massachusetts Special Olympics; a visit from law enforcement and education officials from the country of Tajikistan; and more. Published by the External Affairs Division, the Common Ground newsletter is available in print form for employees and visitors and electronically on the Department's website: www.scsdma.org. It is also transmitted via the Internet to any organizations or individuals who request it by visiting the Department's website and submitting an email address through the newsletter sign up box at the top left of the webpage. To read the current edition of Common Ground or to view copies of back issues, visit: www.scsdma.org and click the "News" tab beneath the main photo box. |


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Int. J. Mol. Sci. 2013, 14(1), 394-410; doi:10.3390/ijms14010394
Nitric Oxide Synthesis Is Increased in Cybrid Cells with m.3243A>G Mutation
Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, R. Pedro de Toledo, 781, São Paulo 04039-032, Brazil
Department of Neurology and Cell Biology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
* Author to whom correspondence should be addressed.
Received: 7 October 2012 / Revised: 10 December 2012 / Accepted: 14 December 2012 / Published: 24 December 2012
(This article belongs to the Special Issue Advances in Free Radicals in Biology and Medicine)
Nitric oxide (NO) is a free radical and a signaling molecule in several pathways, produced by nitric oxide synthase (NOS) from the conversion of L-arginine to citrulline. Supplementation of L-arginine has been used to treat MELAS (mitochondrial encephalopathy with lactic acidosis and stroke like syndrome), a mitochondrial disease caused by the m.3243A>G mutation. Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes. Although clinical benefits have been reported, little is known about NO synthesis in MELAS. In this study we found that osteosarcoma derived cybrid cells with high levels of m.3243A>G had increased nitrite, an NO metabolite, and increased intracellular NO, demonstrated by an NO fluorescent probe (DAF-FM). Muscle vessels from patients with the same mutation had increased staining in NADPH diaphorase, suggestive of increased NOS. These results indicate increased production of NO in cells harboring the m.3243A>G, however no nitrated protein was detected by Western blotting. Further studies are necessary to clarify the exact mechanisms of L-arginine effect to determine the appropriate clinical use of this drug therapy.Keywords:
mitochondria; nitric oxide; arginine; mitochondrial disease; mitochondrial DNA
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Gamba, J.; Gamba, L.T.; Rodrigues, G.S.; Kiyomoto, B.H.; Moraes, C.T.; Tengan, C.H. Nitric Oxide Synthesis Is Increased in Cybrid Cells with m.3243A>G Mutation. Int. J. Mol. Sci. 2013, 14, 394-410.
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