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Artificial Thymus Tissue Enables Maturation of Immune Cells
Their results represent the first step towards the production of artificial thymus glands that could be used to replace or augment the damaged organ.
The thymus plays a key role in the bodys immune response. It is here where the T lymphocytes or T cells, a major type of immune defense cells, mature. Different types of T cells, designated to perform specific tasks, arise from progenitor cells that migrate to the thymus from the bone marrow. Researchers at the Max Planck Institute of Immunology and Epigenetics in Freiburg have generated artificial thymus tissue in a mouse embryo to enable the maturation of immune cells. In this process, they discovered which signaling molecules control the maturation of T cells. Their results represent the first step towards the production of artificial thymus glands that could be used to replace or augment the damaged organ.
As part of the immune response, the T cells are responsible for tracking down and destroying intruders and degenerated cells in the body. Their progenitors are formed in the bone marrow. Attracted by chemical signals, they migrate from there to the thymus. This small organ, which is located above the heart, is divided into niches that provide the cells with environmental conditions necessary for their different development phases. The cells mature there into different types of T cells, which are eventually released into the body.
Signaling substances that are active in the various niches of the thymus play a crucial role in the maturation of the progenitor cells. A combination of four proteins the two chemokines Ccl25 and Cxcl12, and the cytokine Scf, and the Notch ligand DLL4 determines whether progenitor cells are attracted to a particular niche in the thymus and how they develop there. It was not previously known which combination of factors is responsible for the development of a particular cell type.
Researchers from the Max Planck Institute in Freiburg have now succeeded in explaining the control mechanism. The development of the progenitor cells depends on surprisingly few factors and follows simple rules, says Thomas Boehm. For example, just two factors, namely Cxcl12 and DLL4, are sufficient for the T cell progenitors to complete half of their development. From that point, it takes just a few steps until two types of mature T cells with the CD4 and CD8 surface molecules are formed. Previously, it was assumed that the control process was far more complicated, explains the scientist.
In order to test how the different combinations of the four genetic factors affect the maturation and differentiation of the immune cells, the researchers created an artificial thymus environment in the mouse embryo. To do this, they switched off the transcription factor Foxn1. Fox1 ensures that all of the genes in the DNA that code for the four different proteins are read. Foxn1 is thus a kind of general switch with which all of the relevant genes can be turned off all at once. Having generated non-functional thymus tissue in this way, the researchers then activated the genes again individually and in combination and observed the associated effects on the development of the progenitor cells.
Interestingly, the scientists were also able to attract the progenitors of B lymphocytes and of mast cells to the artificial thymus environment and allow them to mature there. These two types of immune cells normally only develop in the bone marrow. By switching off the Notch ligand DLL4, the researchers were also able to control the maturation of these cells in the artificial thymus. This would suggest that the genetic factors at work in the bone marrow are similar to those in the thymus.
Our results are not only of relevance to the understanding of fundamental immunological processes, says Thomas Boehm, they also constitute early milestones in the development of artificial thymuses. This means that one day we may be able to help patients whose thymus has been damaged, for example as a result of cancer treatment, hopes the scientist.
Illustration: Reconstitution of a dysfunctional thymic rudiment (green cells) by two factors attracts numerous hematopoietic cells (red cells). Nuclei of all cells are stained in blue. © MPI of Immunology and Epigenetics.
Read more
Max-Planck-Gesellschaft News Release (03/29/12)
Science Daily (03/29/12)
e! Science News (03/29/12)
Abstract (Cell; Vol. 149, Issue 1, 159-172 (03/30/12))
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Young Scientist Helps Identify Cause of Widespread Eye Disease
Researchers Reveal Role of Dendritic Cells in Type 1 Diabetes
Autoimmune Disease: Retraining White Blood Cells
Team Studies Role of White Blood Cells in Kidney Failure
Study Shows Starving Cancer Cells of Key Nutrient Slows Tumor Growth
Cancer Stem Cells Isolated From Kidney Tumors
Delivering Stem Cells by Post Means More Effective Global Treatment
New SARS-Like Virus Infects Both Human and Animal Cells
Salmonella Spreads by Targeting Cells in Our Gut, Study Shows
Valuable Tool for Predicting Pain Genes in People: 'Network Map' of Genes Involved in Pain Perception
Cocktail Boosts Immune Cells in Fighting Cancer
A Relationship Between Cancer Genes and the Reprogramming Gene SOX2 Discovered
Rapid Eye Movements Significantly Delayed in People with Glaucoma
Inducing Stem Cells to Become Different Cell Types Efficiently Now Possible Using a Three-Dimensional Platform
Study Reports Breakthrough in the Understanding of Embryonic Stem Cells
How Different Nerve Cells Develop in the Eye: Development in Fish Embryos with Aid of 4D Recordings
Stem Cell-Derived Dopaminergic Neurons Rescue Motor Defects in Parkinsonian Monkeys
Stopping the Flow of Cancer Cells Promotes the Spread of Tumors
Communication Channel Between Cells and Machines Paves Way Toward Bio-Hybrid Robots
Fountain of Youth Technique Rejuvenates Aging Stem Cells
Brain Cells Made from Urine
Cocktail Boosts Immune Cells in Fighting Cancer
Stem Cells to Aid Search for New Drugs in Hard-to-Treat Conditions
Stem Cell-Derived Dopaminergic Neurons Rescue Motor Defects in Parkinsonian Monkeys
Topical Simvastatin Shown to Accelerate Wound Healing in Diabetes
Study Suggests Different Organ-Derived Stem Cell Injections Improve Heart Function
Scientists Discover New Method of Gene Identification
Newly Discovered Effects of Vitamin D on Cancer
Stem Cells Develop Best in 3D
A Novel Therapeutic Advancement in the Search for Heart Muscle Progenitor Cells Hope for Heart Attack Patients
First Randomized Controlled Trial to Show Spinal Cord Regeneration in Dogs
Stem Cell Clinical Trials to Tackle Diabetes
Bioprinting Has Promising Future
Nanokey Opens Tumors to Attack
Stem Cell Scientists Discover Potential Way to Expand Cells for Use With Patients
A Secret of Tumor Stem Cell Survival: Scientists Make Progress Against a Devastating Cancer
Scientists Identify Progenitor Cells, Potential New 'Roots' of Breast Cancer
How to Make Stem Cells Nuclear Reprogramming Moves a Step Forward
Researchers Discover Turbo Switch of Calcium Pump in Biological Cells
Watching the Cogwheels of the Biological Clock in Living Cells
Breast Cancer Cells Spread by Digging Their Escape Route
Finnish Researchers' Discover New Blood-Vessel-Generating Cell with Therapeutic Potential
Tissue-Engineered Kidneys: Researchers Make Important Strides
Hormone-Producing Thyroid Grown From Embryonic Stem Cells
Zinc Fingers: A New Tool to Fight Against Huntington's Disease
Brain Tumors: Artificial Stimulation of the Immune System Could Mean Less Aggressive Treatment
Researchers Discover How Melanoma Cells Circumvent the Immune System
Two Genes Linked to Increased Risk of Diabetes-Associated Kidney Disease
Sperm and Eggs Created in Dish Produce Mouse Pups
New Human Neurons from Adult Cells Right There in the Brain
Adult Stem Cells Change Their Epigenome to Generate New Organs
Mouse Pancreatic Stem Cells Successfully Differentiate Into Insulin Producing Cells
New Gene-Therapy Approach Could Improve Obesity Treatment
Cloned Receptor Paves Way for New Breast and Prostate Cancer Treatment
Cloned Receptor Paves Way for New Breast and Prostate Cancer Treatment
Human Embryonic Stem Cells Could Help to Treat Deafness
Genetic Test Predicts Risk for Autism Spectrum Disorder
Newly Identified Stem Cell Population in Skin's Epidermis Responsible For Tissue Repair
Protecting Genes, One Molecule at a Time
Singapore Scientists Find Genes Associated With Glaucoma
SickKids First to Grow Lung Cells Using Stem Cell Technology
New Insights into Salt Transport in the Kidney
Green Tea Compound Shows Promise for Tackling Cancer
New Pre-clinical Results: Ex Vivo Applications of RNAi to Enhance Dendritic Cell Vaccines for Cancer
Researchers Identify Which Sensory Nerve Cells Contribute to Chronic Nerve Pain
Stem Cell Therapy Shows Promise in Repairing Stress Urinary Incontinence
Viruses With Integrated Gene Switch
Genes Carried by E. Coli Bacteria Linked to Colon Cancer
Stem Cells Thrive on Superficial Relationships
Nanomaterials Help the Heart to Heal
Blood Cancer Cells Initiate Signaling Cascade
From Microns to Centimeters: Researchers Invent New Tissue Engineering Tool
Breakthrough Treatment Reduces Post-Surgical Scarring For Glaucoma Patients
Vitamin-Boosted Stem Cells Show Promise in Curing Baldness
Dr. Peter Wearden Provides International Assistance with Regenerative Medicine Medical Device
New Gene Therapy Strategy Boosts Levels of Deficient Protein in Friedreichs Ataxia
Regenerating Bone Tissue Using Gene Therapy: New Method May Work With Other Tissues as Well
Microwave Heating Improves Artificial Bone
Mechanisms that Allow Embryonic Stem Cells to Become Any Cell in the Human Body Identified
Single-Cell Parasites Co-Opt 'Ready-Made' Genes from Host: Study
Stem Cell Research Aids Understanding of Cancer
Finished Heart Switches Stem Cells Off
New Target Discovered Deep Within Cancer Cells
How Tumor Cells Create Their Own Pathways
An Economical, Effective, and Biocompatible Gene Therapy Strategy Promotes Cardiac Repair
Origins of Key Immune Cells Discovered
Amniotic Fluid Yields Alternatives to Embryonic Stem Cells
New Study Finds Genetic Causes of Osteoarthritis
Researchers Prevent Mice from Developing Diabetes
Diabetes Drug Makes Brain Cells Grow
Apolipoproteins Are Biomarkers for Diabetic Retinopathy
Diabetes Reversed in Mice Using Stem Cells
Magnet Helps Target Transplanted Iron-Loaded Cells to Key Areas of Heart
Stem Cell Transplantation into Mouse Cochlea May Impact Future Hearing Loss Therapies
Anchoring Points Determine Fate of Stem Cells
European Researchers Crack Embryonic Stem Cells Mystery
Self-Organized Retinal Tissue from Human Embryonic Stem Cells
Regenerated Cells May Restore Vision After Corneal Dysfunction
Japanese Scientists Show 'New' Liver Generation Using Hepatocyte Cell Transplantation
Export Extravaganza in Human Cells
Anti-Psychotic Drug Pushes Cancer Stem Cells Over the Edge
Stem Cell Researchers Map New Knowledge About Insulin Production
Stem Cell Research Paves Way for Progress on Dealing With Fragile X Retardation
Nine New Breast Cancer Risk Genes: Landscape of Cancer Genes and Mutational Processes in Breast Cancer Complicated
Prosthetic Retina Offers Simple Solution for Restoring Sight
Patients' Skin Cells Turned Into Heart Muscle Cells to Repair Their Damaged Hearts
Human Neural Stem Cells with Tumor Targeting Ability Discovered
New Stem Cell Found in Brain: Finding Could Be Key to Developing Methods to Heal and Repair Brain Injury and Disease
Photoreceptor Transplant Restores Vision in Mice
Hair Regeneration from Adult Stem Cells
Key to New Antibiotics Could Be Deep Within Isolated Cave
Skin and Umbilical Cord Cells Turned Directly Into Nerve Cells
Growing Where No Cell Has Grown Before
Gene Gives Cells a 'Safety Belt' Against Genetic Damage
Trinity Researchers Report Major Eye Disease Breakthrough
Asthma: A Vaccination That Works Using Intramuscular Injection
Defect in Transport System Causes DNA Chaos in Red Blood Cells
Scientists Shed Light on How Liver Repairs Itself
REST Molecule Acts as an Adapter in Stem Cells
New Zealand Scientists Discover How Infection Triggers Blood Stem Cell Growth
Engineering Bowel Transplants
Somatic Stem Cells Obtained From Skin Cells for First Time Ever
Double Whammy: RNAi Enhances Lung Cancer Therapy
Largest Gene Therapy Trial for Cystic Fibrosis Begins
New Lab Model of Alzheimers Disease Will Help Research
A New Short Cut for Stem Cell Programming
Stem Cell Study Aids Quest for Motor Neuron Disease Therapies
Neurons Change Shape After Gene Therapy
Research Breakthrough Shows Promise in Offsetting Cornea Transplant Rejection
Researchers Discover a Switch That Controls Stem Cell Pluripotency
UBC-Vancouver Coastal Health Researcher Discovers New Type of Spinal Cord Stem Cell
Rare Immune Cells Could Hold Key to Treating Immune Disorders
Heart Failure's Effects in Cells Can Be Reversed with a Rest
Osteoporosis Drugs May Increase Risk of Serious Eye Disease
Artificial Thymus Tissue Enables Maturation of Immune Cells
Cheek Progenitor Cells Found to Be Vastly More Potent at Immunosuppression than Bone Marrow MSCs
How Cells Brace Themselves for Starvation
Live From the Thymus: T-Cells On the Move
Bioengineering to Repair and Generate Healthy Skin
A Recipe for Isolating and Growing Human Intestinal Stem Cells at the Lab Bench
Synthetic Protein Amplifies Genes Needed for Stem Cells
Few Genes Control Neuronal Function
Human Stem Cells Improve Vision in Rats With Glaucoma-Like Nerve Cell Damage
Scientists Make Groundbreaking Discovery on Stem Cell Regulation
British Study May Improve Glaucoma Assessment and Treatment
Clean Correction of a Patient's Genetic Mutation
High Level of Stem Cells in the Blood May Be Associated With Favorable Prognosis for Myeloma Patients
Stem Cell Research Could Prevent Premature Births
Dental Pulp Stem Cells Transformed by 'Bad Breath Chemical
Stem Cell Approach Primes Immune System to Fight Cancer
Reprogramming Stem Cells to a More Basic Form Results in More Effective Transplant, Study Shows
Erasing the Signs of Aging in Cells is Now a Reality
UQ Researchers Make Breakthrough in Stem Cell Research
Researchers Discover Key to Immune Cell's 'Internal Guidance' System
Queensland Researchers Make Cancer Treatment Breakthrough
Stem Cells Can Repair a Damaged Cornea
Report Shows Risk of Blindness Halved Over Last Decade
Lithocholic Acid Kills Cancer Cells But Not Healthy Cells
Collaborative Research Sheds Light on New Cancer Stem Cell Therapies
Therapeutically Useful Stem Cell Derivatives in Need of Stability
Scientists Shed New Light on Link Between 'Killer Cells' and Diabetes
Naturally Produced Protein Could Boost Brain Repair
Hopes for Reversing Age-Associated Effects in MS Patients
Aging-Related Degeneration Can Be Caused by Defects of Energy Metabolism in Tissue Stem Cells
Three New Eczema Genes Discovered
Bone Marrow-Derived Cells Differentiate in the Brain Through Mechanisms of Plasticity
No Brakes on Breast Cancer Cells
Gene Therapy Achieves Early Success Against Hereditary Bleeding Disorder
Scalable Amounts of Liver and Pancreas Precursor Cells Created Using New Stem Cell Production Method
New Discovery of Adult Stem Cells Gives Fresh Possibilities For Heart Regeneration
Genome-Wide Study into New Gene Functions in the Formation of Platelets
Stabilizing Entangled Spaghetti-Like Materials: Controlling Forces Between Oppositely Charged Polymers Opens New Route For Gene Therapy Vectors
Singapore Scientists Lead Human Embryonic Stem Cell Study to Advance the Field of Regenerative Medicine Research
Researchers Decode a Puzzling Movement Disorder
Stem-Cell-Seeded Bioartificial Tracheal Transplant Feasible
New Muscle Repair Gene Discovered
MedUni Vienna: Key Gene Function Against Cell Death Discovered
Jamb and Jamc Are Essential Proteins for the Fusion of Muscle Cells: Study
Alzheimer Brain Destroyed By Too Many Blood Vessels
Lasers Light the Path to Neuron Regeneration
Scientists Announce Human Intestinal Stem Cell 'Breakthrough' For Regenerative Medicine
Scientists Make Historic Breakthrough in Cancer Therapy Trial
Scientists Discover How Cancers Generate Muscle-Like Contractions to Spread Around the Body
Discovery Could Create Retinas From 'Jell-O'
New Research Validates Clinical Importance of Leukemia Stem Cells
Mural Cells from Saphenous Vein Could Have Long-Term Benefits in Heart Attacks
'Open Wide' For New Stem Cell Potential: Stem Cells of the Oral Mucosa Stay Young
Research Discovers Frequent Mutations of Chromatin Remodeling Genes in TCC of the Bladder
New Resource to Unlock the Role of MicroRNAs
Chained Muscle Tissue Culture Develops Blood Vessels and Aligned Structure
Researchers Combine Stem Cell with Artificial Chromosome to Treat Duchenne Muscular Dystrophy in Mice
Insect Virus Holds the Key to Safer Stem Cell Therapy
Protein Switch Controls How Stem Cells Turn Into New Heart Tissue
Stem Cell Breakthrough Heralds New Era of Therapy Development
Stem Cell "Memory" Can Boost Insulin Levels
Genetic Study Sheds New Light on Ankylosing Spondylitis
"Genetic Dimmer Switch" Regulates Wiring in the Developing Brain
Gene Therapy Stimulates Protein That Blocks Immune Attack and Prevents Type 1 Diabetes in Mice
The Forces of Attraction: How Cells Change Direction
UBC Researchers Invent New Drug Delivery Device to Treat Diabetes-Related Vision Loss
Serum-Free Cultures Help Transplanted MSCs Improve Efficacy
Singapore Scientists Discover How to Control Fate of Stem Cells
Blue Light Enables Genes to Turn On
Molecular Glue Sticks It to Cancer
Nanotubes to the Rescue: Brain Cells Rescued by Gene Silencing Offers New Options for Stroke
New Approach to Cancer Vaccines Proves Successful in Early Studies
New Genetic Technique Converts Skin Cells Into Brain Cells
Heart Has Built-in Repair Mechanism
Cancer-Seeking 'Smart Bombs' Target Kidney Cancer Cells
Silencing a Deadly Conversation in Breast Cancer
MDC Researchers Discover Key Molecule for Stem Cell Pluripotency
Scientists Find New Drug Target in Breast Cancer
Scientists Boost Antitumor Effects of Dendritic Cell Therapy Using Inflammatory Virus
Stem Cell Treatment to Prevent Leukemia Returning is a Step Closer
New Drugs Target Delay of Huntington's Symptoms
Rare Tumors 'Fingerprint' Used to Develop Cheap and Reliable New Test
Cell Therapy Aims to Prevent Transplant Rejection
Combo Method Reveals Cells' Signal Systems
Team Develops Platform to Monitor Hematopoietic Stem Cells
Cell Therapy to Prevent Organ Rejection
New Marker Offers Hope for More Reliable Detection of Prostate Cancer
Liver Cells Made in the Lab Using Skin Cells: Study
Cancer Scientists Discover New Way Breast Cancer Cells Adapt to Environmental Stress
The Sweet Mysteries of the Nervous System
Discovery Demonstrates Potential MS Therapy Could Kill Brain Cells
Researchers Discover Protein That Could Help Prevent the Spread of Cancer
Tekmira and the National Cancer Institute Publish Promising Data Demonstrating the Anti-Tumor Activity of a Novel Cancer Target
Simple Injection Could Limit Damage from Heart Attacks and Stroke
First Successful Transplantation of a Synthetic Tissue-Engineered Windpipe
Gene Find Could Aid Nerve Repair
Successful Strategy Developed to Regenerate Blood Vessels
Tiny Antibody Fragments Raised in Camels Find Drug Targets in Human Breast Cancer Cells
Scientists Make Skin Repair Discovery
Scientists Identify Key Trigger for Pancreatic Beta Cell Regeneration
Researchers Mimic Body's Own Healing Potential to Create Personalized Therapies for Inflammation
Womb Cancer Genome Scan Reveals Prostate Cancer Link
University of Granada Researchers Make the First Bioartificial Organ in Spain
The Self-Made Eye: Formation of Optic Cup from ES Cells
Newly Discovered Epigenetic Tag Offers Insight into Embryonic Stem Cell Regulation
Periodontal Stem Cell Transplantation Shows Promise
Molecular Muscle: Small Parts of a Big Protein Play Key Roles in Building Tissues
New Study Pinpoints Why Some Microbial Genes are More Promiscuous Than Others
Trapping Prostate Cancer Cells to Keep Them from Spreading Provides Hope
Two-Pronged Approach Brings Hope for Bowel Cancer Treatment
New Cell Therapy a Promising Atherosclerosis Treatment
Gene-Fuelled Transporter Causes Breast Cancer Cells to Self-Destruct
Gene Responsible for Severe Osteoporosis Disorder Discovered
Genetic Abnormalities Associated With the Creation of Stem Cells Discovered
Stem Cell Study Could Aid Motor Neuron Disease Research
Scientists Discover Cause of Rare Skin Cancer That Heals Itself
Human Umbilical Cord Blood Cells Aid Diabetic Wound Healing
Cancer-Related Pathways Reveal Potential Treatment Target for Congenital Heart Disease
Personalized Medicine Comes Within Reach
Worlds First Chemical Guided Missile Could Be the Answer to Wiping Out Cancer
Canadian Researchers First Worldwide to Generate Pluripotent Stem Cells From Horses
U of Alberta Researcher Discovers Potential Cancer Therapy Target
How Nasal Stem Cells Might Prevent Childhood Deafness
Boosting Bodys Immune Response May Hold Key to HIV Cure
McMaster Discovery Provides New Insights into Pluripotent Stem Cell Biology
Early Infusion of Donor T Regulatory Cells Prevents Graft-Versus-Host Disease and Enhances Immune Recovery in High-Risk Blood Cancer Patients
Erg Gene Key to Blood Stem Cell 'Self-Renewal'
Reprogrammed Stem Cells Hit a Roadblock
Partnership of Genes Affects the Brain's Development
Immune Interaction Optimizes Fetal Nourishment During Pregnancy
New Anti-HIV Gene Therapy Makes T-Cells Resistant to HIV Infection
DMP1 Protein Inhibits Angiogenesis, Could Lead to New Treatments Against Cancer and Other Diseases
Research Shows How Pathogenic Bacteria Hide Inside Host Cells
Dynamic Systems in Living Cells Break the Rules
Uncovering the Trail Behind Growing Too Old, Too Soon
Blocking Rogue Gene Could Stop the Spread of Most Cancers
Red Blood Cell Hormone Modulates the Immune System
Patient-Derived Stem Cells Could Help Test Cardiac Disease Treatments
Skin Provides Australia's First Adult Stem Cells for Friedreich Ataxia
Nanodisk Gene Therapy
Scientists Now Know Why Some Cancers Become Malignant and Others Don't
Scientists Bring New Hopes to Translate Human Stem Cell Technologies to the Clinic
Scientists Find the Master Switch for Key Immune Cells in Inflammatory Diseases
Researchers Find Critical Link Between Down Syndrome and Alzheimers Disease
Punctuated Evolution in Cancer Genomes
Australian Researchers Identify Gene Mutations That Sabotage Kidney Function
Two Genes Linked to Common Gynecological Disease
Study Reveals New Possibility of Reversing Damage Caused by MS
Some Brain Tumors Mimic the Genetic Program of Germline Cells
Leukemia Stem Cell Discovery
Degradable Scaffolds for Tissues
A Double Block of Blood Vessels to Starve Cancerous Tumors
Medicine: Alzheimer's and Heart Attacks Share the Same Genes
TB Bacteria Use the Body's Stem Cells to Protect Themselves
Study Shows That Blood Stem Cells are Influenced by Their Offspring
Fitting a Biological Nanopore into a Man-Made One, New Ways to Analyze DNA
New Microscope Reveals Ultrastructure of Cells
Transcription Factor Scan Identifies Genetic Cause for Inherited Blindness
Overactive FTO Gene Does Cause Overeating and Obesity
Team Finds Mutation Involved in Macular Degeneration
Origin of Cells Associated With Nerve Repair Discovered
Umbilical Cord Cells May Treat Arthritis
Rogue Gene Hijacks Stem Cells to Jumpstart Human Cancer
Breakthrough in Cancer Vaccine Research
ISMETT Celebrates Transplant Number 1000
Pediatric Living-Related Liver Transplant at ISMETT
Scientists Find Non-Viral Pathway of Blood Cancer Development
How Do We Kill Rogue Cells? Assassin's Tricks Revealed
Not All Stem Cells the Same, Say McMaster Researchers
Scientists Turn Stem Cells into Cells for Cartilage Repair
Scientists Uncover Strategy to Effectively Target Drug Resistant Childhood Cancers
Stem Cells Shape Up to Their Surroundings
Scientists Reveal Gut Stem Cell Secrets
Visionary Stem Cell Technique Offers New Potential to Treat Blindness
Scientists Unravel Genetic Risk of Bowel Cancer
Scientists 'Clone' Human Virus Responsible for Congenital Malformations and Other Life-Threatening Diseases
Major Genetic Risk Factor for the Most Common Form of Glaucoma Discovered
Uncovered: New Ovarian Cancer Gene (A Connection Between Cancer and Endometriosis)
Twins Help Researchers to Find Genes for Blindness
Identifying Stem Cell Suicide Triggers with ROCK
Accelerating the Understanding of Personalized Medicine
B Vitamins Slow Brain Atrophy in People with Memory Problems
Smoking Damages Fertility
Scientific Breakthrough to Pave the Way for Human Stem Cell Factories
First Genetic Link to Common Migraine Exposed
Insulin Resistance, Type 2 Diabetes Linked to Plaques Associated With Alzheimer's Disease
Scientists Describe How Physical Environment Influences Stem Cell Development
Important Breakthrough in Origins of Aggressive Breast Cancer
Toolbox of MiniPromoters for Gene Research and Therapy Unveiled
All Genes in One Go
Seeing the World With New Eyes: Biosynthetic Corneas Restore Vision in Humans
Gene Therapy to Treat Epilepsy a Step Closer
Liver Cells Created From Patients' Skin Cells
New Stem Cell Discovery a Preliminary Step for Regenerative Medicine
Slippery DNA Holds Clues to Fighting Diseases That Progress with Age
Otago Researcher Helps Identify Gene Linked to TB Susceptibility in Africans
Stem Cells from the Thymus Reprogrammed to Become Skin Stem Cells
Starvation Gene Could Make Resistance Futile for Ovarian Cancer Cells
Personalized Genome Sequencing in Cancer TreatmentA Major Breakthrough in Care
Genetic Signature in TB Patients Sheds Light on Disease
Genetic Differences That Make Some People Susceptible to Meningitis Revealed
Gene Affecting Chronic Pain Identified--Opens Way for New Treatment Approach
Herpes Virus Treats Head and Neck Cancer Patients
Manipulating Cells With a Micro-Suction Cup
New Discovery Brings Hope to Treatment of Incurable Blood Cancer
Scientists 'Reprogram' Mouse Fat Cells Into Clinically Useful Stem Cells
Toxic Trio Identified as the Basis of Celiac Disease
Bid to Aid Transplant Cancer Patients
Gene Find Offers Breast Cancer Hope
Potential Cure Discovered for Degenerative Vision Diseases Leading to Terminal Blindness
Cells' Grouping Tactic Points to New Cancer Treatments
Finding May Pave Way for New Treatments for Muscle Wasting Diseases
New Discovery in Nerve Regrowth
Tel Aviv University Develops Method for Tracking Adult Stem Cells as They Regress
UK Clinical Trial: Stem Cells to Treat Knee Osteoarthritis
Stem Cell Transplantation of Therapy-Resistant Chronic Leukemia Successful
Reversal of Fortune for Parkinson's Disease Transplant Treatment
Potential Cancer Cause Uncovered
Revolutionary Medical Dressing Uses Nanotechnology to Fight Infection
Prostate Cancer Study's Dramatic Results
Stem Cell Therapy May Provide New Approach to Fight Infection
12 New Genes Linked to Type 2 Diabetes
Microbial Protein Restores Vision in Blind Animals
Identification of a Novel Tumor Suppressor
Bees Help to Beat MRSA Bugs
Mechanism Explains Complications Associated With Diabetes
Stem Cell Breakthrough Offers New Hope for Lung Disease Patients
Scientists Identify Three New Genetic Variants That Increase Testicular Cancer Risk
Mechanism Behind Three Cancer-Causing Genes in Acute Lymphoblastic Leukemia
Rare Genetic Variations Involving Whole Sections of DNA Implicated in Autism
Reprogramming Immune System Cells to Produce Natural Killer Cells for Cancer
Obstacles to Stem Cell Therapy Cleared
Dental Pulp Cells for Stem Cell Banking
How the Wrong Genes Are Repressed
Down's Syndrome Chromosome Yields More Cancer-Blocking Genes
Ancient Viral Invasion That Shaped the Human Genome Found
Sleeping Sickness Study Offers Insight Into Human Cells
New Therapy Offers Hope to Spinal Muscular Atrophy Patients
Scientists Find Genes Associated With Throat Cancer
Transplant Tolerance 'Signature' Identified
Progress in Exploring New Avenues for Brain Repair
New Findings Complicate Use of Stem Cells
Study Sheds Light Into the Nature of Embryonic Stem Cells
Harnessing the Power of Stem Cells to Unlock the Secrets of Motor Neuron Disease
Stem Cells From Adipose Tissue Turned Into Cardiac Myocytes: Achievement Paves Way for Future Heart Disease Therapies
Genetic Link to Risk for Diabetes and Weight Gain: New Study
Funnel Vision: New Info About How Cells in the Eye Help Guide Light Into the Retina
Researchers Discover New Mechanism in Stem Cell Regulation
Researchers Agree on Future of MS Stem Cell Research
Researchers Design New Biomaterial That Mimics Muscle Elasticity
Junk DNA Drives Cancer Growth
Researchers Modify Virus to Hunt Down and Wipe Out Cancer Cells
Finding Has Direct Impact on Regenerative Medicine and Assisted Reproduction
Link: Ovarian Hormone to Breast Stem Cells Growth
Bone-Marrow Stem Cells in MS Show Promise
Prenatal Smoking Can Lead to Psychiatric Problems in Children
Scientists Create Artificial Human Skin with Biomechanical Properties Using Tissue Engineering
Chinese Scientists Discover Marker Indicating the Developmental Potential of Stem Cells
Major Breakthrough Offers Hope of Preventing Mitochondrial Diseases
Substance in Breast Milk Kills Cancer Cells
New Discovery Could Speed Up Liver Repair
Hormone Sensitivity of Breast Stem Cells Presents Drug Target
Insulin-Producing Cells Can Regenerate in Diabetic Mice
Gene Therapy Boosts Recovery From Heart Attack
Potential to Produce the Large Quantities of Human Embryonic Stem Cells Required for Transplantation
Hormone Replacement in Joint Fluid Has Potential Regenerative Effect
Tomato Genes Produce Promising Results Against Brain Tumors
Using Stem Cells to Mend Damaged Hips
Surgeons Transplant New Trachea Into Child Using His Own Stem Cells to Rebuild Airway
How to Fortify the Immunity of HIV Patients
Gut Flora Genes Dwarf Human Genome
Predicting the Fate of Stem Cells
Research Builds on Genetic Link to Autism and Schizophrenia
How Nerve Cells Grow
Genetic Link Between Mammographic Density and Breast Cancer
Study: Stem Cells Sabotage Their Own DNA to Produce New Tissues
Bacteria Toxic to Wound-Treating Maggots
Stem Cells Rescue Nerve Cells by Direct Contact
Novel Theory for Mammalian Stem Cell Regulation
How to Shoot the Messenger
Targeting Cancer Stem Cells in the Lab
Did Bacteria Develop Into More Complex Cells Much Earlier in Evolution Than Thought?
Scientists Map Epigenome of Human Stem Cells During Development
Regenerative Medicine and Transplantations: How the Immune System Produces T Cells
'Junk DNA' Could Spotlight Breast and Bowel Cancer
'Fountain of Youth' for Stem Cells?
Metastasis Formation Revealed in Detail in Real Time
Acutely Damaged Livers may be Repaired via Transplanted Hepatocytes
Leprosy Susceptibility Genes Identified
Gene Identified as Cause of Some Forms of Intellectual Disability
Stroke Drug Kills Cancer Cells and Leaves Normal Cells Intact
Why Cancer Cells Just Won't Die: Researcher Identifies Protein Which Regulates Cell Suicide
It Takes Two to Infect: Structural Biologists Shed Light on Mechanism of Invasion Protein
Genetic Analysis Helps Dissect Molecular Basis of Cardiovascular Disease
Polyphenols and Polyunsaturated Fatty Acids Boost the Birth of New Neurons, Study Finds
Umbilical Cord Blood Stem Cell Transplant May Help Lung, Heart Disorders
New Understanding About Mechanism for Cell Death After Stroke Leads to Possible Therapy
First Reconstitution of an Epidermis from Human Embryonic Stem Cells
Scientists Discover Cells That Control Inflammation in Chronic Disease
Cross-Country Runabouts: Immune Cells on the Move
Paradoxical Protein Might Prevent Cancer
Survival of the Healthiest: Selective Eradication of Malignant Cells
Dementia: Rare Brain Disorder is Highly Hereditary
Gene Therapy Repairs Injured Human Donor Lungs for the First Time
Testicular Tumors May Explain Genetic Mutations in Children
Adipose-Derived Stem and Regenerative Cells Show Potential in First-in-Man Treatment of Stress Urinary Incontinence
Blood Counts Are Clues to Human Disease
Research Points to Potential Chink in Cancer's Armor
Sophisticated Genetic Engineering Improves Insulin-Producing Beta Cells
Cholesterol Necessary for Brain Development, Study Finds
Step Forward for Nanotechnology: Controlled Movement of Molecules
Retinal Rescue: Cells Derived From Human Embryonic Stem Cells Reverse Retinal Degeneration
Discovery of Regulatory Role of Key Molecule: Step Towards Future Gene Therapy to Control Disease
Microchip That Can Detect Type and Severity of Cancer Created
Alzheimer's Researcher Demonstrates Specific Immune Response to Vaccine
How Stem Cells Make Skin
Genes Identified may Help Breast Cancer Diagnosis
New Role of Vitamin C in Skin Protection
Key Protein Controlling Brain Formation Identified
Master Gene that Switches on Disease-Fighting Cells Identified by Scientists
Why Don't Brain Tumors Respond to Medication?
Silenced Genes as Warning Sign of Blood Cancer
Think Zinc: Molecular Sensor Could Reveal Zinc's Role in Diseases
Parkinson's Disease: When Cells Run Out of Fuel
Switching on the Power of Stem Cells
Watching Stem Cells Repair the Human Brain
Nano-Magnets Guide Stem Cells to Damaged Tissue
Scarring Key to Link Between Obesity and Diabetes
Researchers Successfully Reverse Multiple Sclerosis in Animals
Viral Mimic Induces Melanoma Cells to Digest Themselves
Cancer Cells Are Protected by Our Own Immune System
Researchers Learn How Blood Cells 'Talk'
Stem Cell 'Daughters' Lead to Breast Cancer
Discovery of a Mechanism Controlling the Fate of Hematopoietic Stem Cells
Placenta-Derived Stem Cells May Help Sufferers of Lung Diseases
Critical Link in Cell Death Pathway Revealed
Researchers Discover Genetic Circuit That Regulates Behavior of Stem Cells
Asperger Syndrome, Autism, and Empathy: Study Links 27 Genes
Stem Cells: Environmental Factors Instruct Lineage Choice of Blood Progenitor Cells
Circulating Blood Cells are Important Predictors of Cancer Spread in Children
Improving Mouse Heart Function Following Heart Attack
New Weapon in the War Against HIV-AIDS: Combined Antiviral and Targeted Chemotherapy
Cancer is Second Most Frequent Cause of Death in Individuals with Schizophrenia
Synthetic Biology: Gene Therapy Gets Under the Skin
Second Chance for Dangerous T-Cells
How Cancers Spread to the Brain
Health Risks of Nanotechnology: How Nanoparticles Can Cause Lung Damage and How the Damage Can Be Blocked
Vaporized Viral Vector Shows Promise in Anti-Cancer Gene Therapy
New Way to Enhance Stem Cells to Stimulate Muscle Regeneration
Fruit Fly Stem Cells Filmed Live
Revolutionary Ultrasonic Nanotechnology May Allow Scientists to See Inside Patients Individual Cells
World First: Chinese Scientists Create Pluripotent Stem Cells from Pigs
Model for New Generation of Blood Vessels Challenged
Non-Wovens as Scaffolds for Artificial Tissue
Bone Marrow Stem Cell Co-Transplantation Prevents Embryonic Stem Cell Transplant-Associated Tumors
Cancer: Detecting, Targeting, and Disabling Tumor Cells, All in One Step
White Blood Cells Can Sprout 'Legs' and Move like Millipedes
Bones Made from Human Skin Connective Tissue
Potential Preventative Therapy for Type 1 Diabetes
Upside-Down World: DNA Protecting Protein Helps Cancer Drug to Kill Cells
Stem Cell Focus for IBD Wound Healing
Diabetes: MicroRNA Protects Beta Cells
Human Stem Cells Promote Healing of Diabetic Ulcers
Learning Disabilities in Males: Nine New X Chromosome Genes Linked to Learning Disabilities
Stem Cell Therapy Grows New Blood Vessels
Scientists Synthesize Gold to Shed Light on Cells' Inner Workings
Large Quantity of Stem Cells Produced from Small Number of Blood Stem Cells
Common Virus Kills Cancer Stem Cells
Researchers Reveal How Immune Cells Can Be Harnessed to Target Melanoma
Geologists Research Could Provide Breakthrough for Heart Patients
Regulatory Molecule for Tumor Formation or Suppression Identified
Dendritic Cells Ensure Immune Tolerance
Experts Use Nanotech to Deliver Anti-Cancer Genes
Stem-Cell Repair Kit for Stroke
Secrets of C. Difficile's Protective Shell Revealed
Viscosity Changes in Cancer Cells Studied
The Making of an Intestinal Stem Cell
Tiny Tool to Control Growing Blood Vessels Opens New Potential in Tumor Research
A Stem Cell Bandage for Your Knee
An Inexhaustible Source of Neural Cells
Study: Cell Injections Accelerate Fracture Healing
New Genes Involved in Acute Lymphoblastic Leukemia Play Fundamental Role in Prognosis of the Disease
Adult Stem Cells Convert Into Embryonic-like Stem Cells, With Single Factor
'Nonsense' in Our Genes: One in 200 Human Genes Superfluous?
Surgical Implants Coated with One of 'Nature's Antibiotics' Could Prevent Infection
Advancement in Tissue Engineering Promotes Oral Wound Healing
Stem Cells Used to Reverse Paralysis in Animals
How Cancer Cells Survive a Chemotherapy Drug
Inflammation Worsens Danger Due to Atherosclerosis
Scientists Successfully Develop Novel Biomaterial to Help Grow New Blood Vessels
New Mechanism Regulates Type I Interferon Production in White Blood Cells
Bone Marrow Stem Cells Used to Regenerate Skin
Scientists Call Up Stem Cell Troops to Repair the Body Using New Drug Treatments
Older Women Who Are More Physically Fit Have Better Cognitive Function
Key to Future Medical Breakthroughs is Systems Biology, Say Leading European Scientists
Brain Birth Defects Successfully Reversed Through Stem Cell Therapy
Breakthrough in Understanding Development of Type 1 Diabetes
Heart Regenerates After Infarction -- First Trials with Mice
Type 1 Diabetes and Celiac Disease Linked
Gene May Make Kids Crave Junk Food
Between Dormancy and Self-Renewal: Mouse Model Shows Blood Stem Cells in Action
New Targeted Fluorescent-Imaging Compound Allows Researchers to Detect Viable Cancer Cells in Mice
Dormant Stem Cells for Emergencies
Stem Cell Research Hold Great Promise, but Obstacles Remain, Expert Argues
The Light Syringe
Portuguese Scientists Discover New Mechanism that Regulates Formation of Blood Vessels
Immune Cells Reveal Fancy Footwork
New Approach Keeps Tumor Cells from Refueling
Pure Insulin-Producing Cells Produced in Mice
Neurons Derived from Embryonic Stem Cells Restore Muscle Function After Injury
Adult Stem Cell Breakthrough: First Tissue-Engineered Trachea Successfully Transplanted
Pfizer Launches Global Regenerative Medicine Research Unit
A New Laser Technique Seals and Heals Wounds
Jumonjd3: A Key for Unlocking Neuronal Stem Cell Fate
Intraspinal Implant of Mesenchymal Stem Cells May Not Heal the Demyelinated Spinal Cord
Heartbeat Supplements Power to Run Implanted Medical Devices
Umbilical Cord Blood May Help Build New Heart Valves
Completely Novel Action of Insulin Unveiled
Skin Cancer: Designer Molecule Tackles Malignant Cells by Two Completely Different Routes
Stem Cell Therapies for Heart Disease One Step Closer
Singapore Develops Cell Therapy Treatment for Cancer
New Artificial Heart in Preclinical Testing in Europe
Cold Virus Found to Manipulate Genes
Scientists Trigger Cancer-like Response from Embryonic Stem Cells
New Properties of Skin Stem Cells
Breast Stem Cell Fate is Regulated by 'Notch'
A Key Mechanism Regulating Neural Stem Cell Development is Uncovered
Stem Cells From the Testicle: True Alternative to Embryonic Stem Cells
Cornea Uses Stem Cells to Repair Itself
Scientists Identify New Bone Protecting Protein
Treating Vitiligo With a New Cell Therapy
Scientists Identify for the First Time the Genes that Cause Blindness Produced by Corneal Oedema
New Site Launched for Families and Scientists to Discuss Stem Cell Research
Human Embryonic Stem Cell Secretions Minimized Tissue Injury After Heart Attack
Gene Expression Profile Shared by Pluripotent Stem Cells Found
New Stem Cell Screening Tool Takes Adult Stem Cell Research to New Level
Stem Cell Research Compares Methods of Creating Patient-Specific Stem Cells
Scientists Reveal Changes to Embryonic Stem Cells Caused by Down Syndrome
New Stem Cell Tools to Aid Drug Development
Researchers Replicate Insulin-Producing Cells, Providing New Hope for Diabetics
New Discovery About Growth Factor can be Breakthrough for Cancer Research
Blood Vessel Cells are Instructed to Form Tube-Like Structures
Animal Testing Could Soon Be a Thing of the Past
Cells in Eye Could Help Control Sleep
Trial: Tumor Regressions Achieved in Relapsed Lymphoma Patients
Potential New Treatment for Alzheimers Disease
Robot with a Biological Brain: New Research Provides Insights into How the Brain Works
SickKids Scientists Uncover the Key to Controlling How Stem Cells Develop
Building the Bionic Body
Human Embryonic Stem Cells Developed from 4-Cell Embryo--World First May Lessen Ethical Concerns
Bath Researchers Study How Cancer Cells Come Unstuck
Why Gene Therapy Caused Leukemia in Some "Boy in the Bubble Syndrome" Patients
Sugar Study is Sweetener for Stem Cell Science
Insulin-Producing Cells Can Give Rise to Stem-Like Cells In-Vitro
Standards in Stem Cell Research
New Approach to Cancer: Find Most Tightly Controlled Genes
Genetic Variation Increases HIV Risk in People of African Descent
Genetic Profiling for Breast Cancer on the Horizon
Doughnuts Deliver Drugs
Stem Cell Therapies Offer Patients Hope and Reduced Health Care Costs
Measuring the Footprint of Cells
Adult Stem Cell Findings Offer New Hope for Parkinson's Cure
Inhalable Form of Gene Therapy Takes Aim at Lung Cancer and Inflammatory Lung Disease
Gene Therapy Involving Antibiotics May Help Patients With Usher Syndrome
Discovery of New Family of Genetic Mutations Involved in Inflammatory Intestinal Disease
Rapid Wound Healing With Dressing Made of Silica Gel Fibers
Saving Teeth by Using Periodontal Ligament Regeneration
Mapping of Prostate Cancer Genes Opens the Door to New Treatments
Vancouver Researchers Pioneer Safe Pathway to Slow ALS Using Stem Cells
Bone Repair Using Patient's Own Stem Cells
Transfusable Blood From Stem Cells
Pioneering Induction of Bone Formation Using Embryonic Stem Cells
Muscle-Derived Stem Cells Prove Effective in Repairing Sphincter Damage to Restore Continence
Discovery May Reverse/Prevent Cognitive Decline That Occurs During Ageing Dementia
Genes Linked to Osteoporosis Identified
Stem Cell Type Supposed to be Crucial for Angiogenesis and Cancer Growth Does Not Exist
Cancer Cells Spread by Releasing 'Bubbles', According to New Study
Tiny Magnets Used in Anti-Cancer Gene Therapy
Stem Cell Hope for Fixing Injured Knees
Clearer Day for Gene Therapy: New Vector Carries Big Genes Linked to Inherited Blindness
Manchester University Announces Stem Cell Breakthrough
New Venture for Therapy with Cord Blood and Adult Stem Cells
World-First Stem Cell Screening Facility to Target Brain Tumors
Way to Target Genes Devised for Gene Therapy
Stem Cell Funding for Parkinsons Disease
Stem Cell Breakthrough Offers Diabetes Hope
Scottish Consortium to Start Work on 3D Cell-Based Assay
Post Brain Injury: New Nerve Cells Originate From Neural Stem Cells
Lifetime Probability of Needing a Stem Cell Transplant is Much Higher Than Previously Reported
Deep-Brain Stimulation for Alzheimers Patients Considered
Cheek Swab Kits Successful in Recruiting Bone Marrow Donors
Breakthrough Technique Restores Light Sensitivity in Damaged Retinas
Monash Pioneers Nano Scaffold to Rebuild Nerve Damage
Stem Cell Therapy Trials to Mend Shattered Bones Coming Soon
Patient Gets New Jaw Cultivated From Own Stem Cells
Atlantic Veterinary College: New Technology Heals Horses Faster, Stronger
Imitating Monkeys Jumping Genes Could Lead To New Treatments for HIV
Human Clinical Trials of Stem Cell Treatment That Could Replace Bone Marrow Transplants
New Acute Lung Injury Study Finds Benefits of Autologous Cell Transplantation Therapy
Helmet Helps Alzheimers Patients
Polymer Gel Prevents Skin Grafts from Shrinking
'Telepathic' Genes Recognize Similarities in Each Other
Discovery: Mutations of a Part of the X Chromosome Lead to Mental Retardation
Treatment for Brittle Bones Before Birth
Twins Confirm the Beginning of Childhood Leukemia
Macular Degeneration Stem Cell Therapy Repair May Be On the Horizon
Lab-Grown Brain Cells Could Treat Parkinsons Disease
Gene Suppression Enhances Wound Healing
Research on Treatments to Improve Muscle Loss Due to Disease and Aging
Gene Therapy Experiences Another Setback in UK
Growing Artificial Skin From Hair Roots
Gene Therapy May Protect Against Alcoholism
Regenerative Medicine Researchers Use Fat to Repair Breast Defects Following a Lumpectomy
Regenerative Medicine Aid: New Ultrasound Device Determines Best Time for Skin Transplant
Muscular Dystrophy May Be Helped Through Regenerative Medicine Therapy
Face Transplant Patient Doing Well Today
Regenerative Stem Cell Therapy Helps Memory
New Source for Dopamine Cells May Help Those With Parkinsons Disease
Important Step in Development of Artificial Nerves via Regenerative Medicine
Endometrial Regenerative Cells: New Adult Stem Cells for Regenerative Medicine
Adult Stem Cell Product to be Tested in Regenerative Medicine Stroke Trial
New Regenerative Medicine Stem Cell Treatment Reduces Amputations in Critical Limb Ischemia
Using Stem Cells to Treat Damaged Eyes and a Rare Skin Disorder
Regenerative Medicine Efforts Honored: 2007 Prix DExcellence Award
Inauguration of the Clinical Translation Unit
Treatment of Vascular Risk Factors Slows Advance of Alzheimers
Skin-Derived Stem Cells Repair Spinal Cord Injuries in Rats
Gene Therapy in Rats Reduces Rheumatoid Arthritis Swelling
Growing Heart Valves
Novalung: Bridge to Lung Transplant
Stem Cell Subtype Discovery Could Lead to Improved Bone Marrow Transplants
Bone-Strengthening Drugs May Benefit Young Stem Cell Transplant Recipients
"Off-the-Shelf" Skin Grafts
Stem Cells Grow Kidneys in Mice
New Source for Stem Cell Line
One For the Road: An Alcoholics Last Shot?
Discovery Could Lead to Regenerative Therapies for Muscular Disease
Gene Therapy Works to Eradicate Bowel Cancer Cells
Gene Therapy Trial for Treatment of Lebers Congenital Amaurosis (LCA)
Bone Marrow May Help With Future Male Fertility Treatments
Stem Cell Treatment for Runners
Stem Cell Treatment for Recently Diagnosed Type 1 Diabetics
Liver Cells Grown From Cord Blood


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subset: commoncrawl


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Moffitt Cancer Center's Genitourinary Oncology Program provides state-of-the-art care and develops newer, more effective therapies for patients with testicular cancer. We also treat other genitourinary cancers of the male and female urinary systems (the bladder, kidney and ureters), as well as men's cancers of the penis and prostate.
Call 1-888-MOFFITT Make Appointment Sign Up For Email
Our team features multiple disciplines, including physicians, nurses, clinical trial coordinators and other health care professionals who support the patient-physician relationship and the care of patients and their loved ones. We hold weekly conferences to discuss cases, obtaining several different specialists' feedback and determining the next steps for patient care. This interdisciplinary approach results in highly coordinated, expert, quality patient care and greater patient satisfaction.
Urologic Cancers Prostate, kidney, bladder and penile cancers can occur at any age but are far more frequent in older patients. Because Florida has many senior citizens, the incidence of certain urologic cancers is higher here than in other areas of the United States. Just a few years ago, a cure for many urologic cancers was a rarity. The trend today toward early detection of cancer is expected to lead to improved survival rates. Advances in surgical techniques and radiation therapy have helped to improve the quality of life of many patients with urologic cancers by reducing the incidence of impotence in men and the side effects related to the bowel and bladder.


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We STILL seem to have a RANDOM ARCHIVE GLITCH where clicking on the next comic will take you to the next comic page, but oddly display a comic from a totally different date. Hitting Refresh sometimes helps. We're working on it!
Comic for Monday 09/07/09
Some layout/pencils-stage scans this three-day weekend.


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Orange Port Authority Silk Touch Sport Shirt by Port Authority
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text: Cathedral of St. Louis King of France A Minor basilica - Established as a Parish in 1720 615 PERE ANTOINE ALLEY, NEW ORLEANS, LA. 70116 Oblate Fathers 17 September 1973 Telephone 525-9585 Mrs. Norman W. Core Route 1 Almyra, Arkansas 72003 Dear Mrs, Core: How nice to hear from you, and I do appreciate your sending the enclosed copies - everything bit helps in piecing these families together. I cannot send a Xerox copy of the funeral but this is because the book is in such bad condition. However, this is a translation of the actual record: FUNERAL REGISTER 1772-1790 - Page 27 In this year of seventeen hundred and seventy-three and this seventeenth day of October, I the undersigned interred in the cemetery of this Parish, the remains of CATHERINE LANDRONY aged about thirty-three years, the wife of Mr. LAMBERT, caval- ryman, she died on the sixteenth day of this same month, having received the sacraments of her religion and in faith I have signed /S/ F. Ferdinand [Notes by Dorothy Core in reference to above paragraph.]>1773 age 33< SAME BOOK - PAGE 8 In this year of seventeen hundred and seventy-two and this third day of October, I the undersigned interred in the cemetery of the Parish, the remains of CATHERINE FRANCOEUR a native of Arkansas, of the age of thirty years, and wife of PIERRE PERTHUIS called LA GENEURY, she re- ceived the sacraments before her death, and in faith I have signed /s/ F. Ferdinand, Vicar [Notes by Dorothy Core in reference to the above paragraph.]>1772 age 30< FUNERAL REGISTER 1793-1803 Page 90 On this twentieth of June of eighteen hundred, I, Fr. Flavian, Religious Capuchin assistant cure [curé is the proper term] of this Holy Cathedral of New Orleans, interred in the Holy Ground of the parish cemetery the remains of JOSEF, a male child of PEDRO GIRON and of JUANA LANDRONI and in faith I sign /s/ F. Flavian de Besancon


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Berrix wrote:ddddd wrote:Maybe they should try to get some games for WiiU that have already been denied
Have we gotten a few denied Wii U releases already? I didn't know we even had enough to be denied with just yet.
Though, to be honest I would love to see Earth Seeker come stateside, even if an eShop release, or better reworked with utilize some Wii U features.
I was refering to the usual third party BS. If we are talking strictly about Japanese games, there are a few announced games not coming (for example, either Metal Gears, Suda51's new game)


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Expecting a baby or planning for the future? Come to a short presentation to learn all about our maternity services.
Registration is closed.
Find out about having your baby at Tri-City Medical Center at our Childbirth Maternity Tour. Expectant moms and their guests are invited to attend. Learn more about the care you will receive during and after childbirth. Take a tour of our Maternity Unit. No charge for this event.
We encourage you to make reservations in advance, as they are required to attend.
Please register for each person who will attend
For additional information in Spanish please call (760) 940-5750.
Para más información por favor llame a (760) 940-5750.
Childbirth Services at 760-940-5784
This class covers infant CPR and safety practices.
Thinking about breastfeeding? Get the information you need to start off right!
Learn how to care for your infant once you're home together.
The information in this class is to prepare mom-to-be and her partner for the labor and delivery experience.
At this location Tri-City Medical Center Beginning on May 15, 2013
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Welcome to The Holding Company.
You are here:Home > Units > QBO Modular Storage Cubes
Form and function are combined within these hardwearing but beautiful stackable storage cubes. You can customise and create the storage system you need with these lovely storage cubes. You choose - do you want solid doors, perforated doors - no doors at all? Shelves, legs or castors? Coloured or monochrome? The choice is entirely yours. Make a bold living storage system, or build an understated but practical office unit.
If you would like to discuss your QBO Cube Storage System with one of our team, feel free to give us a call on 020 8445 2888 and we will be happy to answer any questions you may have.
Unit 2
Finchley Industrial Centre
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London N12 8QA
t: 020 8445 2888
f: 020 8445 1100


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Top Definition
a feeble/clumsy attepmt at picking up with a girl, usually resulting in other males laughing ruthlessly at the culprit
Oh man, that was a tickner of ann effort, my grandmother could do better!
Por jono smith
23 de agosto de 2006
1 more definition
A mole on your body that when stroked stimulates sexual arousal. Only on mammals that have sex.
"Whoops, don't touch my Tickner baby"
Por Fuge Ken
02 de agosto de 2009


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Accessing Shopping Bag
Stand-up paddleboarding is one of our most popular water sports. It's great exercise and an easy way to explore scenic waterways. Find a day tour, overnight trip or course below that's just right for you – starting at $25. Sign up today.
The best way to try paddleboarding or to improve your paddling skills is to take one of our introductory courses. Led by expert instructors, they provide a great foundation for trying our more advanced courses or exploring on your own. Sign up today.
Stand-up paddleboarding yoga allows you to relax your mind, tone your body and discover a new level of energy. Come for one session, the whole series or try our SUP Yoga Retreat. See our full selection below. Sign up today.


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Related Media: The Benefits of Regular Exercise
Exercise helps keep your body healthy and your tissues and organs working properly. By keeping your body in good working order, exercise also helps ward off many diseases, such as heart disease , stroke , type 2 diabetes , osteoporosis , and many others.
In 2008, the United States Department of Health and Human Services released physical activity guidelines for Americans. They recommend that adults should do at least 150 minutes of moderate–intensity or 75 minutes a week of vigorous–intensity aerobic physical activity per week. For additional health benefits, they recommend that adults increase this amount to 300 minutes of moderate–intensity or 150 minutes a week of vigorous–intensity per week.
Your exercise program should include:
In aerobic exercise, you continually move large muscles in the legs and buttocks. This action causes you to breathe more deeply and your heart to work harder to pump blood, thereby strengthening your heart and lungs.
Examples include:
Strength training builds lean muscle mass, which increases your physical strength and your bone mass.
Stretching can offer many benefits, such as improving:
Major muscle groups to stretch include:
Stretching classes include:
Here are some tips for safe stretching:
Here are some common stretching mistakes to avoid:
Before starting an exercise program, check with your doctor about any possible medical problems you may have that would limit your exercise program.
Consider making an appointment with a certified athletic trainer to help you develop a safe, effective, and enjoyable exercise program. You can find a trainer at a local gym or through a referral from your doctor or a friend. Make sure this person understands your goals and can help you maintain an exercise program that you will enjoy and stick with.


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Copy: 26th February 2015. Actress Kate Mara will be the 10th recipient of the annual Women In Film Max Mara Face of the Future Award®, in recognition of her extraordinary acting achievement and embodiment of timeless style and grace. In Milan, Italy to meet the Maramotti family, Kate Mara also attended the Fall Winter 2015-16 Max Mara Fashion Show.
Max Mara Art Prize for Women: Corin Sworn presents her new work
Corin Sworn, winner of the latest edition of the Max Mara Art Prize for Women, will be presenting her new work at the London Whitechapel Gallery in May 2015 and at the Collezione Maramotti in October 2015.
Her work is the result of a six months residency in Italy. During this time, Ms Sworn studied the evolution of the Commedia dell'Arte theatre, exploring the theme of "mistaken identity" in plays and on the role of clothing and attire in the 17th and 18th century Italian society.
Collezione Maramotti e Max Mara have had the pleasure to commission a feature-length documentary focusing on the highlights of her project. Watch the trailer.
IO donna magazine and Max Mara invite you to experience a real fashion show dedicated to the Max Mara Bridal Collection.
Sign up now to book your seat on the front row.
On the 10th of January in Miami Florida, Max Mara's Maramotti family proudly sponsored the prestigious, The National YoungArts Foundation Backyard Ball, where among the highlights, Jeff Koons was honored with the 2015 Arison Award.
Max Mara Art Prize for Women and Whitechapel Gallery, London are pleased to announce a special evening of conversation, reading and perfomace with Corin Sworn, winner of the biannual Max Mara Art Prize for Women, on 20th November 2014. The event marks the midpoint of the Prize and draws on Sworn's recent Italian residency and her related project on Commedia dell'Arte theatre troupes. Sworn and the celebrated poet Lisa Robertson will be presenting and performing fragments of their own research materials, writing and notes, as a means to both involve the audience in their work and their working methods. Sworn's new work will be unveiled at the Whitechapel Gallery from 20th May to 19th July 2015, and at the Collezione Maramotti, Reggio Emilia in Autumn 2015.
18th September, Milan - Max Mara presents the Spring Summer 2015 Runway, on the occasion of Milan Fashion Week.
Iconic: inspired by unconventional women who redefined the concept of beauty, for a new and unexpected kind of femininity - youthful, strong, confident and polished.
Discover the Max Mara Spring Summer 2015 Runway
New York September 15th, 2014 – Max Mara announces its partnership with the Whitney Museum of American Art for the opening of the museum's new downtown Manhattan location in Spring 2015.
The new home of the world's leading museum of Twentieth-century and contemporary art - conceived by the renowned architect Renzo Piano - will enable the Whitney to vastly increase the size and scope of its exhibition and programming space, as well as hosting new experimental and multimedia activities.
Max Mara has collaborated with the museum on a number of events, including the annual Whitney Art Party, and will be sponsoring the Opening Party next Spring.
Photographed in New York for Max Mara by the talented Mario Sorrenti, Amy Adams models some of key styles from the range of accessories, such as the iconic Signature Bag and the unmistakable Margaux, as well as the new cutting-edge Tribute frames from the Eyewear collection.
See the Campaign with Amy Adams and the exclusive backstage contents
Shop the Accessories FW 14-15 Collection
12 Luglio 2014 - Celebrating the official opening of the new Max Mara flagship store in Avenue De Luxe, Huamao Center.The boutique is the biggest of the brand's Asian locations, with over 800 square metres of space on four floors.
Designed by the Duccio Grassi Architects studio, the new flagship store is characterised by a striking illuminated façade, destined to become one of the landmarks of luxury retail in Beijing.
During the opening cerimony, Max Mara presented in world preview the "Heritage" Installation: created by the Migliore+Servetto Architecs studio, the installation is a journey into the history of the maison, blending unreleased archive materials and innovative technologies.
Los Angeles June 11th, 2014 - The Honoree received the Award during the Cristal + Lucy Awards® Gala dinner held at the Los Angeles Ballroom of the Hyatt Regency Century Plaza. Women In Film, Los Angeles honours some of the most creative, prolific and socially responsible individuals in the entertainment industry. Rose Byrne has established herself as a rising star of the big screen. Byrne recently completed production on Annie, alongside Quvenzhane Wallis, Cameron Diaz and Jamie Foxx. The Broadway musical remake.
Opening of the new Max Mara store in Copenhagen Airport, Denmark.
The Maramotti family is awarded this year's Whitney Museum's American Art Award, given for sustained commitment to the artistic and cultural heritage of the arts in America and now at its 23rd edition. Maria Giulia Maramotti receives the prize at the 2014 Cerimony on 7th May. The Whitney Museum's Art Party was held the following night at the Skylight in New York City.
Milano Fashion Week, 20th February 2014: the Max Mara Fall-Winter 2014-15 Collection takes to the runway.
Urban landscape: Anglo-Scottish inspration, revisited in a completely metropolitan way.
Watch the video and discover next season's looks.
The winner of the 5th edition of the Max Mara Art Prize for Women in collaboration with Whitechapel Gallery is Corin Sworn, Glasgow based film and installation artist. Her winning proposal draws inspiration from the Commedia dell'Arte, the masked, improvised theatrical performances touring Italy in the 16th Century. Sworn has been awarded a 6 months bespoke residency in Italy.


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How To Buy Camping Stoves And Cookware
When buying camping stoves and cookware, consider how many people you will have to feed and how many meals you will have to prepare on a typical trip. Also, consider whether you prefer gourmet meals or are content with simply boiling water for dehydrated fare. Your answers will help narrow your choices.
Camp Stoves Basics
Think of your camping plans and destination prior to buying a stove.
Size and weight
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Cartridge Stoves
Liquid Gas Stoves
Choosing the right cookware