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Producer Les Tomkins know Tubby well and recalls :"It was a happy live session, as usual, and the room was full of teenagers dancing and having fun. This was the Friday night jazz club I was running in 1950 in Raynes Park, S.W. London. A rather corpulent local lad, who laughed a lot, loudly, had turned up for the first time, bringing a gang of his mates. After listening for a while, he pushed his way up to the stand and said he'd like to sit in. The ebullient Lennie Hastings was the drummer. "What do you play then?" asked Lennie. "Tenor, but I haven't brought it with me." (Actually, it was in a pawnshop at the time.) The only saxophonist in the group was a baritone player - "Do you want To try this?" "Sure" said the lad - and proceeded to blow up a veritable storm for the rest of the evening. We were all staggered by the display of jazz virtousity. Before the boy wonder left, he gave me his card. "Edward Brian Hayes" it said. This was the great Tubby - at fourteen.
Later that year the club moved to a larger hall in Sutton, Surrey - and I put Tubby in charge of the resident band. One week the star guest band was led by Ronnie Scott. Tubby was lapping up Ronnie's searing jazz, and we urged him to ask if he could join him for a couple of tunes. He was reluctant to do so, but eventually he did - and a tremendously exhilarating "battle of the tenors" followed. Eight years on, Tubby and Ronnie were to join forces to form the magnificent Jazz Couriers.
A few weeks after the meeting with Ronnie, some of us - including Kenny Graham. I remember - took Tubby over to a club in Acton, where he sat in with trumpet star Kenny Baker. Kenny was so bowled over by Tubby's talent that he hired him for his Sextet. That year with Kenny marked the launch of the Hayes career as a world-class British jazz artist. He worked with the big bands of Roy Fox, Ambrose and Vic Lewis; he went to the States and recorded with Clark Terry, Roland Kirk, James Moody, among others.
The absolute tragedy is that for all his immense potential, for all his development as an arranger/composer, as a player on vibes and flute as well as the tenor, as the leader of his own bands, such as the eight piece Little Big Band, the Downbeat Big Band (co-led with Jackie Sharpe) and as a partner in the Couriers, Tubby's short life ended so prematurely while he was still in his thirties.
This collection represents three years of Tubby Hayes productivity. Between 1963 and 1966 at Ronnie Scott's Club, I was able to preserve examples of his inventive interaction with various other fine British musicians. During this period as you will hear, Tubby switched over from the quintet he had with trumpet man Jimmy Deuchar to the more flexible format of a quartet.
Because his exuberance would tend to take hold of him, Tubby built a reputation for dazzling technical displays. Therefore the two ballads here have a special significance. Spring Can Really Hang You Up the Most - complete, un-usually, with the verse - illustrates the control and timing of his vibes playing. I'm Old Fashioned gets a luxuriously spaced-out reading, wherein, rather than showing any Coltrane influence, as was sometimes said, Tubby evokes the tonal beauty and lyricism of Stan Getz.
Tubby's thoughts on the 'technique' controversy were; "I read these things where people say 'too many notes' and so on, and, quite honestly, I couldn't give a damn. I play as I want to play. And I can play a ballad - I love playing ballads. I mean, a set is a set. I don't go in and say: 'Right, we're going to play a slow one, a fast one, a medium one, a ballad and tear-up.' T hat's not jazz - that's more like show band business. We go on the stand and we may feel like playing something down - or we may feel like playing fast ones all right. It's purely self-expression. Maybe you could fault me there for not really catering for the public. But if I was catering for the public, I wouldn't be playing what I'm playing - I'd be paying the old twang-twang, wouldn't I?"
The fact of the matter is: Tubby Hayes was one of the most wonderfully consistent and consistently wonderful musicians Britain has produced."
Track List:
1)Half A Sawbuck 2)Spring Can Really Hang You Up The Most 3)The Simple Waltz 4)I'm Old Fashioned 5)Night And Day You can pre-order now


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Deftones are pleased to announce a special signing in support of Record Store Day, this Saturday April 16th at Portland's Music Millennium
This signing will start at 2pm PST. The first 100 fans to purchase a copy of the RSD exclusive Covers EP or Diamond Eyes album will get the chance to meet the band. Make sure to get there early.

subset: commoncrawl


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Oh, joy. Christmas came early! (and no, that's not what mrs. santa said)
Ah, I can see I am debating with a highly intelligent and distinguished gentleman with worldly tastes. Hey?
I do remind you, sir, that Mir would never have been possible without Wayland. Without all the groundwork done by the Wayland devs, all the plumbing and preparing of the graphics stack... Mir couldn't have been. The structure of the Mir server was copied (not in literal sense, but as in, they looked at Wayland to see "this is how to do it") and some parts were indeed copied straight on (XMir is a 1:1 copy of XWayland, with slight changes maybe).
I say, old chap, is that spittle coming from your mouth? Careful, you'll drop your monocle.Abominable............ lmfao what a fucking carry on!!!
No? They have been lying at every turn, spreading malicious lies about their competition, acted with hostility towards the entire community... I would call that "doing wrong", but perhaps you have a differing opinion? Could it be, that your tastes are simply so refined that I just can't grasp them? Maybe there is some higher form of enjoyment to be found in being lied to and slandered, that only a gentleman of your caliber can appreciate. Maybe such customs are common in your household? How intriguing!O please they have done nothing wrong
Ah, sir, I must say - truly, your composure and skills in the art of debate are nothing short of marvelous. I stand in awe at your rapier wit. Awe, I tell you. Well done, sir. I couldn't have said it better. Pray tell, where do you come up with such exquisite material? If I may, sir, the whole "get a fucking life loser" was an excellent touch. Such refined taste... such elegance!Even if true so what? Its a problem for ubuntu/canonical
It wont affect you since you wont ever go near it so why carry on about it day after day. Get a fucking life loser
Sadly, I can only offer my humble counter in my own, feeble words... it is indeed my problem, because what Canonical does affects the rest of the ecosystem, the rest of the community. They have much influence, like it or not, and they should take some responsibility how they use it.
I'm in tears. Seriously, tears. Such beauty! Such elegance! Such an ingenious grasp of the art of wordplay. I am speechless!Blah blah blah games on wayland are going to face the same fucking issues.Since you don't use ubuntu why such a concern anyway?
Sir, I am offended. I consider myself a paragon of honesty.liar
Quite.What a travesty he changed his mind gaaaaawd
That's it? It's over already? Aww.
This is true since Unity came around, but what was meant is if Ubuntu had a total and complete failure to the point of both Ubuntu and Canonical being defunct status. Some would probably go pure Debian while I would guess a lot would go join LM and use their LMDE edition.
If Debian get off it's ass and release some up to date package's on release day ill use it but atm Debian 7.1 is so far out of date it's not funny what do you get out of it 2 or 3 year old package's, the LTS Kernal is the only part not out of date, i'm using Linux Mint here, but i want to see Debian stop being so far out of date it's not funny, maybe if it did like openSUSE on it's EOL's and Releases i use it, openSUSE has what kernal 3.7 and updated package's, and you get support for around 15mo's, i can remember
Xubuntu user here and I agree, that is one thing I don't like about Debian. I'm kind of person that likes having the very latest (currently running Xubuntu 13.10 dev release). Also find things easier to do through Ubuntu than directly through Debian, as I have tried LMDE in the past and it confused the hell out of me for some reason. xD
So now when I ask you to back up your claims I am a hater? That is really an astonishing discussion technique, one could think you are Bill O'Reilly.
For sure, Red Hat will go down when Ubuntu fails. Suse will do the same, you say? And Slackware, a distro existing for 20 years now, without using Canonical technology? Wow, just wow.Ubuntu has become too big to fail. If it fails it takes everybody down with it.
Without Wayland they wouldn't even have XMir, so how fast is it again? Maybe tomorrow I fork GCC and claim that everybody should support me, because I have created a compiler with the feature set of GCC in one day, moving so fast. The only difference to Mir/XMir would be that my fork actually would work.So you should actually learn to support Mir and all the devs focus on it especially since it moves so fast and leave Wayland for later.
I have seen you make this claim before and asked you to back that up with actual data. Do you think that you can do it this time? I seriously doubt it, since backing up claims seems not to be part of your discussion technique, but I ask anyways.Linux on the desktop is where it is due to Ubuntu.
Wait, does this mean that you have factual data on that and that that data tells us that Ubuntu has more than 50% marketshare in the Linux space? Would you like to show us that data? Oh, wait, I forgot that you don't do such things.Everybody should actually help them since most Linux users are Ubuntu users.
Wait, didn't you just state that Linux on the desktop is where it is because of Ubuntu? Now you attribute that to Stallmann?If Ubuntu dies everybody moves back to Windows and Linux will go back to basement dwellers, their dogs and Richard Stallman the loser weirdo who said that Ubuntu is bad and the community should teach them a lesson. It is the opposite in fact, Richard Stallman and his loser friends need to shut up and go to their corner. They've had their time. All they got was a shitty 1% of the market. Now fuck those jokers and let's try something else!
Wheren't you the one who stated that supporting Canonical is the right thing to do so that all other distros can die? Now you say the exact opposite, not supporting Ubuntu will harm the other distros? May it be that you today do not know anymore about your arguments from yesterday?Do you understand that by sabotaging Canonical you are actually sabotaging yourselves? Even you Gentoo users! Linux benefits from having many users.
Again, do you mean those distros that in your opinion shouldn't even exist? Now they suddenly will benefit from Canonical?Do you want it to wither all away, all that was gained so hard and for so much toil? Your rebellion against Canonical will come back to bite your asses. In fact it will chew you whole. So the only option for now is to support Canonical, even if you don't agree with all their decisions. Their success will trickle down to lesser used distros.
You mean like: They brought themselves down with their shitty decisions and now those that do the actual work have to pay for that? Thank Bob that it is not to late, yet, those that really support Linux and bring it forward are not Canonical developers, but developers from Red Hat, Intel, IBM and others, those who actually make money of Linux, not some rich clown dreaming of being the next Steve Jobs.Canonical is basically like the American banks in 2008.
I only can ask you again, although you won't even consider to do it: Back up your claims or GTFO.


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Top Definition
Any Harley Davidson Motorcycle that has a rubber mounted engine. Models such as Road King, Street glide or Ultra classic. Most likely outfited with over sized saddle bags and luggage compartments. They are often operated by rubs that drive them to the Stealership for the weekly HOG meetings.
Hey Bart, did you see the size of that geezer glide. That thing had to weigh twice as much as the old ladys 1972 coupe deville.
de dww459
22 mai 2009
Photos & Videos


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DIGITS LLC was founded in 2006 to fill the need in the legal and corporate communities for highly skilled digital forensics, proactive cyber security services, corporate computer investigations, cyber security incident response and advisory services, eDiscovery and litigation support services, and general digital forensic consulting needs.
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Variable HC15EA : Informal agreement (written)
Format: character Width: 1 |
Valid case(s): 62 (26.1)
Invalid: 0 (0) |
File: hl
De jure household members (usual residents)
Source of information
Head of household or other responsible household member
Literal question
Do you have any documentation or agreement for the rental of this dwelling? Ifyes: What kind of document or agreement do you have for the rental of this dwelling? Anything else?
Record all items mentioned.
Interviewer instructions
This is a probe question for households where there is no written rental contract for the dwelling ('2' in HC15D). If 'Yes', ask "WHAT KIND OF DOCUMENT OR AGREEMENT DO YOU HAVE FOR THE RENTAL OF THIS DWELLING?" Continue to ask, "ANYTHING ELSE?" prompting as necessary until no further responses are forthcoming. Note that both written and verbal agreements should be recorded in this question. In other words, the presence of a document or an agreement is recorded based on the perception of the respondent. Do not use your judgement in terms of the validity of the document or agreement mentioned.


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A lot of people, who know me, always ask how I managed to learn playing guitar without any formal training. For many, online guitar lessons are just a way to improvise, and not learn the basics. Well, I proudly stand out as an exception among my group of friends. Attending formal conventional classes is not my cup of tea due to erratic work schedules. Thus, I decided to sign up for best online guitar lessons on a couple of best instrument learning website and after 1.5 years of dedication and practice, at my own pace and convenient time, I can play any song of my choice without any hesitation. Best part is that even if I forget to use some chords, or feel confused, I simply use my handheld device (mobile phone, tablet or laptop), access some tutorial videos where I know I will get my answer, refresh my skills and just hit it! Taking online classes for learning guitar is one of the best decisions I've had made so far. Otherwise, with so many responsibilities and work pressure, I'd have never been able to learn through conventional methods.
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Last edited by Bluebonnet; 10-09-2012 at 11:39 PM.
I truly hope this is a wake up call to Chan about technical skills and getting a coach. The problem in this world as well as the gift of the world is the great freedom we have. Some obviously "hate" Chan or dislike his skating. Others love him. There is only one Gold medal and everyone wants it and the fans have their favourite. plushy wants anotehr gold is it greed? Maybe but the Russian fans in general want it. You have two complete skaters in Tak and chan and they both want it. "Some say Tak had his day and it is time to move on (Chan lovers probably lol) and others want him to go to Sochi and win (Tak lovers) But only one can get gold. You have Joubert who many would say he has had his 15 minutes now move on but he wants an olympic medal and preferablhy gold. I do miss the purity of love of skating because as much as I love Shen and Zhou it was apparent they just came back for the gold be cause he was injured in 2006 and could only win bronze. AS good asa they were I kind of think that takes something away from the win. Sure we don't really know what is in their hearts (hence, I do believe even the wonderful diplomatic Kwan deep down appreciates when competitors fall - it is horrible to say but human and that would be truthful). I believe Chan and Tak deserve an OGM moreso than Evan did. Sure Evan was a good competitior but people he won and fairly won although it also could have gone to Plushy (the scores show that it was exceptionally close and it could have gone either way). I truly wonder if the pro skating was more profitable, and Japan had hosted the 2011 worlds and Tak won whether Tak would still be around? But I guess that is pointless now. now that I have appreciated their skating I would love to see at Sochi Gold Chan; Silver Tak and Bronze Plushy but somehow I predict the Canadian curse will continue for the Canadian men. I also think on the wake up notion that Skate Canada may want to invite and encourage Buttle to return even as the third skater (and sadly he would be second right now) he's not bad at all especially for the team (triple flip triple toe; triple axel, triple lutz - short). Sure Reynolds sort of has the quads but not much more and they aren't reliable.
"Didn't that coach that he just let go help his jumps?"
I just want to correct what I think is a common misperception. Chan did not fire Krall. Basically Krall left a situation that didn't work for her. I am told by my resources who know the situation that Chan was moving toward a more major role for Johnson and Krall who is used to being a head coach (as well she should) was not on board with being relegated to a 'second-chair' position. How any experienced skating coach could let someone who has never been a skater call the shots beats me; how Chan could expect that it would be agreeable to Krall (if indeed he did expect it) also beats me.
The "second chair' model does not fit Krall's skills, her standing and her experience.
Now, that's Patrick's choice - he set up the situation. Do I personally think he made a mistake? Yes, I do. But that's my opinion.
The fact is that he did not exactly let her go - she wasn't staying.
Last edited by Brandenburg; 10-10-2012 at 08:18 AM.
Nowadays instead of saying, "Fall, fall!" Michelle would go, "Under-rotate, under-rotate!"
Or better yet, "Omit the flying entrance to your second change-combination spin!"
That's what cost Mao Asada first place at the Japan Open.
In the CoP, you get credit for everything you do. If you make a mistake your score is lower, but you still get credit for the positive aspects ofthe element. Chan fell on his quad toe, but still ended up with 59% of full base value even after the -3 GOE and the fall deduction. He got credit for a satisfactory preparation and take-off, adequate height and distance, good form in the air and full revolutions.
Mao missed the flying entrance to her spin. She got 0 credit for making the equired revolutions, good speed and centering, required changes of edge and number and quality of positions. Sorry, cowgirl, you fell off your horse. No gold medal for you.
Now you are talking. You seem finally got it right- Patrick Chan is the only one who can fall twice and he would still beat someone. Even Plu, shining with all his medals, regalia like a Christmas tree doesn't have this previlige. He did land both quads but fell on 2A and singled one of his trixel, still he had a higher BV than Buttle. Yet PCS did their job and the quadless Buttle won over Plu with two quads. Chan PCS over Kozuka is a fair play?
Chan had better be careful - because a few more performances like what we saw at JO and his PCS will drop.
It will have nothing to do with how he skates PCS wise - it's just the way the reputation scoring works in the CoP.
Land enough big jumps and the PCS will rise. Start missing them consistently and the PCS will drop.
And some think 6.0 was hard to figure out........ha!
With all due respect to you and to Plushenko, I see it as quite fair for Chan to have one fall cushion over Plushenko considering what they both have brought here at JO. As of Chan's PCS over Kozuka, I agree with the judges. Kozuka has lost badly in PCS with that music combined with that choreography, and rightfully so.
Oh mein got! That is precisely the scenario that the sport needs right now. Plu, skating perfectly clean in Sochi, with two quads, two trixels and stuff, and Chan who also skates similar clean stuff but falls once on let's say 3L or waxels again his 2A. And yet Chan is over Plu because PChiddy has one fall cusion. Great. Booing in Nice will look like whispering and SLC scandal- like kids' fuss. The last nail in the coffin "fs popularity" and the sport will become a joke irrevocably, means- out of Olympics.
lets talk I guess parsing is not your strong point.... you have totally ignored Blue's subordinate clause......
Then let us all hope PChiddy either skates beautifully, or falls twice.
Will the Russian media be as bad about something like the Patrick wins with a fall scenario as the North American media were about B&S wins with multiple little twidgetty flaws? After all, it is a home Olympics for Plushy.
OK I have pruned about 20 posts out of this thread, and it is now open for posting again.
Please be kind and civil to each other?
Thank you.
All right. I see your post on analyzing my parsing skills is here. So, I will re-reply and hope you will do it in the civil manner too. The subordinate clause was "considering what they both have brought here at JO". Plu showed higher BV and PCS than Chan. Why do you think that it's quite fair that Chan still has one fall cushion over Plu?


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It is very important that RNAi experiments use a delivery method that results in very little cytotoxicity. Cytotoxicity can impact results in a few different ways:
Toxicity is best evaluated by practiced tissue culturists using visual cues. Morphological changes, changes in growth, and gaps in culture density are indications that a culture has been exposed to toxic concentrations of a substance. The following images provide examples of cultures exposed to low, moderate, and high concentrations of a toxic substance. Different levels of toxicity can be defined by visual analysis of cells in culture. As cells are exposed to higher concentrations of a toxic substance, their morphology changes from A, oblong-shaped cells to C, rounded shapes. As the cells continue to round, they eventually detach from the plate or lyse and die.
High Efficiency of siRNA Delivery with Low Toxicity
siLentFect™ is very effective at cytoplasmic delivery of siRNA. Very low volumes of lipid are required per transfection, reducing the cost of each knockdown experiment.
Two characteristics of siLentFect are illustrated below. First, high efficiency is shown by using very low concentrations of siLentFect to achieve sufficient knockdown (ideal range being 0.75 to 2 µl in a 24-well plate). Second, low toxicity is shown by observing the β-galactosidase expression of the nonspecific control siRNA (shown in orange), which was consistent with the untransfected control. With increasing concentrations of siLentFect, culture health is maintained, indicating that siLentFect is minimally toxic at optimal concentrations.
β-galactosidase knockdown using siLentFect and anti-β-gal siRNA. Stable CHO-lacZ cells were produced using the Gene Pulser Xcell™ system and seeded into 24-well plates. Cells were then transfected with 10 nM anti-β-gal siRNA (blue) or a nonspecific control siRNA (orange) using increasing amounts of siLentFect. After 24 hr, cells were assayed for β-gal activity.
Note: The β-galactosidase is a good model because visual x-gal staining for qualitative and ONPG assays for quantitative analyses can be performed. However, β-galactosidase protein is very stable, so ONPG assays for knockdown 24 hr posttransfection are not as representative of reductions in transcript amounts. Knockdown results are biased by the presence of protein that was expressed prior to siRNA delivery, but remains in the cell at the time of assay. This explains the importance of prior characterization of protein stability when using qPCR for RNAi analysis. Knockdown may be 99% of transcript after 24 hr, but persistent protein stability may alter the phenotypic assay results.
Silencing Bias Due to Toxicity
Exposure to toxic levels of a substance can cause cells to lyse and die. This can have a significant impact on evaluating end-point data. In the absence of proper controls, a decrease in expression may appear to represent good silencing but could in fact be due to cell death. Further, cell death reduces the amount of total signal from a culture, making data less robust.
This chart shows the effects of increasing concentrations of two lipids, siLentFect and another lipid (Lipid X). The "anti-luc" lipid traces show knockdown of luciferase in CHO cells stably transfected to express luciferase. However, the control (no knockdown) for Lipid X shows that with increasing concentrations of lipid, the expression of luciferase decreases. This is likely due to cell stress or cell death. siLentFect displays minimal toxicity as shown by only slight reduction in expression for the control sample.
Impact of Toxicity on Optimization
The toxicity of the lipid can influence the amount of optimization that can be performed. If the lipid has a small window of functionality before causing toxicity effects, then the protocol is limited. siLentFect has a broad functional range, in part due to its low toxicity, which allows for greater protocol optimization to accommodate a variety of cell lines. The charts below illustrate the functional range of siLentFect as compared to another available lipid.
COS-7 cells were seeded into 24-well plates and transfected with 0.5 µg of a luciferase reporter gene expression vector (pCMViLuc) and 10 nM of either an anti-luciferase siRNA (—) or a nonspecific siRNA control (—) using different volumes of siLentFect reagent and another lipid (Lipid X). Luciferase activity was measured 24 hr posttransfection. The "anti-luc" traces (blue) show excellent knockdown of luciferase using both lipids, however the control samples (green) show dramatically different results. The siLentFect control sample remains steady, indicating consistent cell viability and very low toxicity. In contract, the Lipid X control sample shows a significant decrease in expression, which is likely due to cell death from high toxicity.
Determining the optimum conditions for transfection efficiency is essential to maximize gene silencing and to minimize cellular toxicity. The two most important parameters to optimize for any given culture vessel and cell density are the amount of siLentFect lipid reagent and the concentration of siRNA. If toxicity is encountered try reducing lipid amounts used in transfection. The amount of siLentFect lipid reagent and the concentration of siRNA required for maximal gene silencing can vary among different cell types.
Typically, siLentFect™ lipid reagent requires less reagent than other lipids for effective siRNA delivery. When working with different lipids or new cell lines, it is important to perform a dilution series of both siRNA and lipids to ensure optimal results.
Optimizing the lipid volume and siRNA concentration. A, CHO cells, stably expressing the lacZ gene, were grown in 24-well plates and transfected with an siRNA targeting lacZ. Cells were lysed and assayed for β-galactosidase activity 24 hr posttransfection. A significant reduction in expression of the lacZ gene product was observed even with low volumes of siLentFect. B, CHO cells, stably expressing the luciferase gene, were transfected in 96-well plates using 0.3 μl siLentFect and a 21-mer anti-luciferase siRNA. The addition of siRNA at concentrations >10 nM did not produce any further significant reduction in luciferase activity. These data also illustrate how siLentFect mediates efficient transfection using very low siRNA concentration and lipid volume.
Suggested Reagent Quantities for Different Sizes of Plates or Wells
* Carefully aspirate medium 15–60 min prior to transfection and add one-half volume of medium.
Other Recommendations for Best Results
siLentFect lipid reagent has been developed to achieve consistent transfection efficiencies using a broad range of cell types with an easy-to-use protocol. Optimum transfection efficiencies are achieved by adjusting:
Once maximum transfection efficiency has been established, the conditions should be kept constant between experiments for any particular cell line.
NIH-3T3 cells transfected with fluorescently labeled siLentMer™ nonsilencing siRNA using siLentFect lipid reagent. At 24 hr posttransfection, cells were fixed and stained with Hoechst dye. A, cells were imaged using brightfield optics B, and then analyzed by fluorescent microscopy to detect nuclear staining C, and siRNA intake. The visualization of the fluorescently labeled siRNA can provide an indication of the transfection efficiency.
Effective Silencing in Co-Transfections
Co-delivery of plasmid containing the gene along with the siRNA is a common way to optimize siRNA delivery and to validate siRNA design. This chart shows that siLentFect™ lipid reagent is very effective for co-transfection of a plasmid and siRNA, while maintaining cell viability.
Co-transfection of plasmid DNA and siRNA. MCF-7 cells were transiently transfected in 24-well plates with different volumes of siLentFect lipid reagent, 0.5 µg of a luciferase reporter gene expression vector, and 10 nM of either a 21-mer anti-luciferase siRNA ( — ) or a nonspecific siRNA control ( — ). siLentFect was allowed to first complex with the siRNAs and then with the plasmid. Luciferase activity was measured 24 hr after transfection. This experiment shows that siLentFect reagent is effective at delivering both plasmid and siRNA to cells to achieve silencing of a gene expressed by a co-transfected plasmid.
Co-Transfection Tips
The Transfection Protocol Online Library contains protocols obtained from the literature, developed by Bio-Rad scientists, or submitted by scientists like you. browse protocols to view our library and find your starting point.
Bio-Rad Laboratories has helped scientists deliver molecules into cells for over 35 years. Instruments, including the Gene Pulser® series of electroporators, the MicroPulser™ electroporator, and the Helios® gene gun and PDS-1000/He™ biolistic systems, have been used successfully to transfect prokaryotic and eukaryotic cells, including plant and animal cells. These transfection instruments are cited extensively in the literature. Our chemically mediated methods include lipid-based transfection reagents — TransFectin™ lipid reagent for delivery of plasmid DNA and siLentFect™ lipid reagent for siRNA delivery.
siLentFect reagent is a high-efficiency cationic lipid developed for the transfection of cultured mammalian cells with short interfering RNA (siRNA). Effective delivery of the siRNA molecules is critical to the success of RNA interference (RNAi) applications. siLentFect has high affinity for the small siRNA molecules, which helps to achieve robust silencing of the target gene with low lipid volumes and low siRNA concentrations. siLentFect reagent is a powerful delivery tool that maximizes efficiency while minimizing cytotoxicity at optimal delivery concentrations.
siLentFect lipid reagent is a mixture of a proprietary cationic compound and a co-lipid. The blend has been optimized for the intracellular delivery of siRNAs into cultured mammalian cells in the presence of serum at cell densities from 50 to 90%. For most cell lines, high levels of gene silencing can be obtained using amounts of siLentFect reagent and siRNA suggested for given sizes of plates/wells.
Key Application
RNAi is a powerful tool used to manipulate gene expression and allow researchers to determine gene function. RNAi is the sequence-specific gene silencing induced by double-stranded RNAs. siRNAs are double-stranded RNA molecules, typically 21–27 nucleotides in length that greatly stimulate gene-specific silencing. siLentFect reagent has been developed to produce exceptional delivery of siRNA to mammalian cells in culture.
Key Features
Other Lipid Reagents
Bio-Rad offers a family of lipid transfection reagents, each of which is optimal for certain applications. siLentFect lipid reagent is an RNAi-specific lipid that is ideal for siRNA delivery. It can also be used to perform cotransfection with a small reporter-plasmid along with the siRNA molecule. TransFectin™ lipid reagent is a general-purpose lipid that is ideal for plasmid delivery.
What is the education discount policy?
For more than 15 years, Bio-Rad has made science education a major priority. To support this effort, the company has implemented a discount policy that allows high school and college teaching laboratories to purchase kits, instruments, reagents, and other equipment at preferred prices.
How do I apply for the education discount?
If you are an educator at the high school or college level, visit our Education Discount Policy page to establish an education account number.
170-3360 0.5 ml, lipid transfection reagent, RNAi-specific lipid for siRNA delivery
170-3361 1.0 ml, lipid transfection reagent, RNAi-specific lipid for siRNA delivery
170-3362 5 x 1.0 ml, lipid transfection reagent, RNAi-specific lipid for siRNA delivery
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Class Title: | Cancer Wellness Support Group - Bryn Mawr Hospital |
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text: There they go again. Both President Barack Obama and former Massachusetts governor Mitt Romney tossed out a blizzard of statistics and facts, often of dubious origin. Here are some highlights. "Governor Romney's central economic plan calls for a $5 trillion tax cut - on top of the extension of the Bush tax cuts - that's another trillion dollars." - Obama "I don't have a $5 trillion tax cut." - Romney How can both facts be true? The $5 trillion figure comes from the fact that Romney has proposed to cut tax rates by 20 percent and other provisions. The nonpartisan Tax Policy Center says that would reduce tax revenue by nearly $500 billion in 2015, or about $5 trillion over 10 years. But Romney also has said he will make his plan "revenue neutral" by eliminating tax loopholes and deductions, although he has not provided the details. The Tax Policy Center has analyzed the specifics of Romney's plan thus far released and concluded the numbers aren't there to make it revenue neutral. In the debate, Romney countered that "six other studies" have found that not to be the case, but he's wrong about that. Those studies actually do not provide much evidence that Romney's proposal - as sketchy as it is - would be revenue neutral without making unrealistic assumptions. Given the uncertainty, the Obama campaign has assumed the worst about Romney's plan-- that it would mean higher taxes for middle-class Americans - even though, as Romney stated, there is no chance he would try to implement such a plan as president. - - - "I've put forward a specific $4 trillion deficit reduction plan. . . . And the way we do it is $2.50 for every cut, we ask for $1 of additional revenue. . . . That's how the bipartisan commission that talked about how we should move forward suggested."-- Obama Obama often claims that his deficit-reduction plan has the "balanced approach" of the Simpson-Bowles deficit commission proposal; the Simpson-Bowles plan is actually quite different. For instance, Simpson-Bowles envisioned $4 trillion in debt reduction over nine years; the president's plan would spread the cuts over 10 years. A good chunk of the savings from deficit reduction piles up in that last year. When the two plans are compared apples to apples, Simpson-Bowles yields about $6.6 trillion in deficit reduction - 50 percent more than Obama's plan. By Obama's math, you have nearly $3.8 trillion in spending cuts, compared with $1.5 trillion in tax increases (letting the Bush tax cuts expire for high-income Americans). That's how he claims $1 of tax increases for every $2.50 of spending cuts. But virtually no serious budget analyst agreed with this accounting. Obama's $4 trillion figure, for instance, includes counting some $1 trillion in cuts reached a year ago in budget negotiations with Congress. So no matter who is the president, the savings are already in the bank. Moreover, the administration is also counting $848 billion in phantom savings from winding down the wars in Iraq and Afghanistan, even though the administration had long made clear those wars would end. In other words, by projecting war spending far in the future, the administration is able to claim credit for saving money it never intended to spend. (Imagine someone borrowing $50,000 a year for college - and then declaring that they have an extra $500,000 to spend over the next decade once they graduate.) - - - "On Medicare, for current retirees, he's cutting $716 billion from the program. . . . The idea of cutting $716 billion from Medicare to be able to balance the additional cost of Obamacare is, in my opinion, a mistake." -- Romney Romney accused Obama of taking $716 billion from Medicare. This $700 billion figure comes from the difference over 10 years (2013-2022) between anticipated Medicare spending (what is known as "the baseline") and the changes that the law makes to reduce spending. Under the health-care law, spending does not decrease in Medicare year after year; the reduction is from anticipated levels of spending in future years. In fact, the savings mostly are wrung from health-care providers, not Medicare beneficiaries - who, as a result of the health-care law, ended up with new benefits for preventive care and prescription drugs. But Romney argued that was a "bad trade," and the Medicare actuary also has raised concerns about whether the cuts to providers were sustainable. While it is correct that anticipated savings from Medicare were used to help offset some of the anticipated costs of expanding health care for all Americans, it does not affect the Medicare trust fund. In fact, the Obama health-care law also raised Medicare payroll taxes by $318 billion over the new 10-year time frame, further strengthening the program's financial condition. Moreover, under the concept of the unified budget, money that is collected by the federal government for whatever purpose (such as Medicare and Social Security payroll taxes) is spent on whatever bills are coming due at that time. Social Security and Medicare will get a credit for taxes collected that are not immediately spent on Social Security, but those taxes are quickly devoted to other federal spending. Indeed, the House Republican budget plan crafted by Romney's running mate, Paul Ryan, retains virtually all of the Medicare "cuts" contained in the health-care law, but diverts them instead to his Medicare overhaul. Republicans argue that that is a more effective use of the savings. - - - "I also want to close those loopholes that are giving incentives for companies that are shipping jobs overseas." -- Obama "You said you get a deduction for taking a plant overseas. Look, I've been in business for 25 years. I have no idea what you're talking about. I maybe need to get a new accountant." -- Romney Romney said he was unaware of any provision that gives companies a tax deduction for moving operations overseas. But Obama is right, there is such a provision. Yet it is pretty small beer given the attention Democrats pay to it. The nonpartisan Joint Committee on Taxation estimated that ending the deduction for moving operations overseas would raise just $168 million over a decade. In the federal government with an annual budget deficit of more than $1 trillion, that's what you call a rounding error. - - - "And over the last two years, health-care premiums have gone up - it's true - but they've gone up slower than any time in the last 50 years." -- Obama Obama tried to attribute a 50-year decline in health costs to the health-care law, but much of it has not yet been implemented. Most economists say the slowdown is more likely because of the lousy economy. "It's tempting to think that provider initiatives are truly denting costs, but it's hard for changes in provider behavior to influence costs before they occur," said a recent article in Modern Healthcare magazine. "Instead, the drop in healthcare cost growth is primarily attributable to the Great Recession's impact on employment, private health insurance, government revenues and budgets." Meanwhile, Romney blamed a rise in insurance premiums on the health-care law. This is also overstated, since much of the health-care law has not been implemented yet.


text:
Arenado takes aim at Cuddyer's Rockies-record streak
Young third baseman can tie mark of 27 games with hit Wednesday
Michael Cuddyer's Rockies franchise-record 27-game hitting streak may be short-lived.
Nolan Arenado will attempt to tie the mark that isn't even a year old when the Rockies visit the Rangers to begin the Texas leg of the split-city four-game interleague series. Colorado won both games at Coors Field.
While Cuddyer was busy building his hit streak last season, Arenado was flashing the leather, earning the first Gold Glove Award by a rookie since 1957. This year, the third baseman has shown he's more than just a pretty fielder -- he has plenty of offensive promise to go along with his glove.
Arenado, who extended his hitting streak to 26 games Tuesday with a two-strike RBI double in the seventh inning, is batting .314. The night was not without drama as Arenado was the last Colorado position player to get a base hit.
"I think he's able to relax now," Troy Tulowitzki said of Arenado's improved approach at the plate. "I think before he was putting a little too much pressure on himself. Knowing that he's a good player and that he belongs here has been key."
On the mound for Colorado as it begins a seven-game road trip will be Jorge De La Rosa. Current Rangers are hitting just .158 off De La Rosa with no home runs in 43 plate appearances.
He will be opposed by Colby Lewis, who is 2-1 with a 4.22 ERA this season. According to Texas manager Ron Washington, Lewis is coming off his best start since a stint of almost two years on the disabled list.
Washington said he is considering getting Mitch Moreland in the lineup Wednesday against the left-hander De La Rosa, despite Moreland's 0-for-7 clip against southpaws this season. Lefties are batting .235 with 12 strikeouts against De La Rosa this season.
"I'm thinking about [playing Moreland on Wednesday] because we need his bat," Washington said. "But then again, I certainly don't want to put himself in a position where he's already set up to fail."
Moreland, who has never faced De La Rosa, pitched a perfect eighth inning of Colorado's 12-1 win Tuesday.
Rockies: Improvement away from home evident early
Though it's early, this year's Rockies have managed to be competitive on the road. They are currently 8-9 away from Coors Field, but hovering around .500 so far can be considered a major success, considering that a season ago, Colorado went 29-52 in away games.
In 2013, the Rockies were outscored by a whopping 101 runs on the road. In order to contend in the National League West, a significant turnaround will be necessary.
"One of the things we've focused on is trying to win every series, and we've done a good job of that so far," Tulowitzki said. "One of the things we've tried to do better is play better on the road, and we're off to a good start. We have to keep that going."
Rangers: Martin moves up in lineup
Looking to inject some offense into the top of his lineup, manager Ron Washington had center fielder Leonys Martin bat second for the first time this season. Martin has made 26 starts batting eighth this season, four batting seventh, and Washington didn't make the move easily.
"I was very hesitant about moving [him]," Washington said. "He's doing well where he is. But going to see if we can get some more offense in the top of the order."
Martin is far from the prototypical No. 2 hitter, where the ability to hit-and-run, make steady contact, move runners and bunt are priorities. Washington said he was concerned about moving Martin to the top of the lineup "because he's a slasher, not an on-base-percentage guy. So until he fully learns what he's capable of doing and how to go about doing it, I try to protect him."
The move might not last until Wednesday's game. Martin went 0-for-2 with a walk Tuesday.
"This is not a permanent thing," Washington added. "It could only last [Tuesday]. But I'll try it and see if it works."
Worth noting
• Lewis, the Rangers' Wednesday starter, left the team before batting practice Tuesday to fly home. The rest of the team isn't scheduled to arrive back to Texas until 4 a.m.
• Jurickson Profar is expected to begin a throwing program when the Rangers return home. He has been on the disabled list with a torn muscle in his right shoulder and is eligible to come off the 60-day disabled list May 29.
• The Rockies' 21 hits Tuesday night were the club's most since September 19 against the Cardinals when they also knocked 21.
Matt Slovin is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text:
The OakTable Challenge goes live whenever the OakTable Network sets up a stand at any of the public user-oriented events. Previous events which have seen an OakTable stand include: Miracle Open World, the UK Oracle User Group annual conference, and the Rocky Mountain Oracle User Group annual conference.
The OakTable Challenge is simple. Ask us (The OakTable members) any technical Oracle-related question and if we cannot provide you with either a solution or/and answer like, "yes", "no", "we need more information" or "cannot be done" within 24 hours, we'll give you a T-shirt that states that you challenged the OakTable Network - and won!


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Enjoy your shopping - and welcome to the future!
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text:
Light table is also a linux friendly kickstarter project.
it's a very innovative IDE with interesting new concepts. On vimeo is a prototype demo. It's currently at $188k , and still 25 days to go, with a goal of $200k. They work on initial support for JavaScript and Clojure. If they reach at least $300k there should be also support for Python. The core of the IDE will be probably open sourced at it's release date.
yes I know there are already quite many IDE's available on Linux, but this IDE looks like it has much potential with its concepts.


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4/28/2015 6:22:31 AM. For Customer Service, please call
While we don't recommend taking this wood stacking boat out on a fishing trip, we think that it will provide hours of fun for your little one. Hand sanded and hand finished, this set of blocks makes a special gift for a boy or girl.


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Top Definition
A woman who is like a goddess, many men find her extremely attractive, shes a real babe. She is also silly although has a habit of laughing at her own jokes. Mikalyn is intelligent and kind also has a very big heart and is caring, perfect mother material. If you know a mikalyn keep her close because she will help you in life and is loyal. Mikalyn will always make you smile.
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Guy 2: YES! Shes a really woman
di Ducky meow
16 marzo 2013
1 more definition
Pervert. Thinks Zach is so freakin awesome, because he's the best person in the whole freakin world. (; **BEAUTIFUL** Very nice! Hilarious. Is mean to Zach. Zach's girlfriend. Special. Likes to makes awesome signs. Super obsessed with manginas. (; Zach loves her. <3
Mikalyn likes manginas!
di Mangina123456789
14 agosto 2011


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October 04, 2012
One of the Fastest-Rising Universities in its Category
October 01, 2012
Third Annual Big Wave Awards Ceremony Will Take Place on October 17, 2012.
September 27, 2012
Keynote Address Presented by Dr. Jeanne Paratore
September 19, 2012
An Interactive Workshop
September 14, 2012
"Imagining the Child Reader, Then and Now"
July 06, 2012
Tinariwen Gives Voice to a People, from Saharan Sands to Monmouth U
February 23, 2012
Book Reading and Signing by Randye Kaye at Monmouth University on March 4
Marie Myung-OK Lee will give lecture "Behind the Scenes in North Korea: The Most Secretive Place on Earth" on March 25
February 22, 2012
The Verge is the University's first student-run online news source
Mr. Lavine's presentation will focus on the business of documentary production.
Psychology Professor Gary Lewandowski was featured on NJFamily.com in February.
February 17, 2012
The Bruce Springsteen Collection at Monmouth University was featured on Philly.com on 2/17.
February 15, 2012
The instructors will focus on basic clinical evaluation of the school age child including both normal and abnormal findings.
This course is designed to expand basic Spanish conversational skills to enhance vocabulary used in the healthcare setting.
February 14, 2012
Firmstone Wins Second-Straight Honor, Nelson Earns First


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Mens Plain Front Leather Pants
ITEM: 4006 These updated plain front pants feature 2 front and 2 back pockets, a front zipper with one-button closure and belt loops. Poly lined to the knee to keep the look smooth. Open hem for easy adjustment. Imported. Leather clean.Learn MoreRegular Price: $300.00
Special Price $120.00


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Reviews & Community
What do you think of the
Mavic Avenge Shoes
? Share a...
Jose Luis
Nice shoes.
Are these compatible with the Shimano A530 SPD Pedals?
Adam Saucedo
Hey there!
The Shimano A530 pedals include a set of Shimano's SH51 SPD cleats in the package which will make them compatible.
Hey I just got the shoes and there is no way that the cleats will make them compatible. The holes are much too wide. Is there a converter or do I just need to send them back and get new shoes?
U want SPD-compatible mtb shoes; these are Look-compatible road shoes.
size is perfact fit ( us size )
Are these UK or US sizes?
Kyle Br
These shoes are sold in US sizes
Kevin K
Mavic UK to US Shoe Size Conversion
Rafael V.
So far so good!
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I live in a warm place. Around 85-90 F on any given day. So to me they could be a bit cooler, but just all around great shoe.
Also super fast shipping and great costumer service by CC.


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- Home >Classic Wall Calendars >Recycled Three-Month Reference Wall Calendar
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AT-A-GLANCE®Recycled Three-Month Reference Wall Calendar
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text:
You should make some benchmarks to compare with his claims. (Like kwin being the most efficient and lightweight WM ?)
Phoronix: Are Compositing Window Managers Lightweight?
With the recent talk about developing a lightweight KDE desktop, the KWin maintainer, Martin Gräßlin, is talking out to try to clarify whether the compositing window manager is lightweight...
You should make some benchmarks to compare with his claims. (Like kwin being the most efficient and lightweight WM ?)
Until someone actually shows me a compositing window manager that uses less CPU than conventional, I call B.S.
Sure.. in *theory*, if you offload everything to the GPU, that means less CPU. In *practice*, it takes more CPU just to send everything over to the GPU than to just process it.
Who cares?
I read through Martin's previous post a bit and it seems to me that the problem is more that some distributions of the KDE desktop don't work well on some hardware, and a certain problem agreeing on what exactly "KDE" is (other than a community).
There's at least memory bandwidth and power usage considerations in that equation that merit benchmarking. For instance, I've seen dedicated 300$ graphics card preform worse in 2D composition than a 5$ Mali 400 SoC core (guesstimating that number...) and not because of bad drivers. Just different usage scenarios.
The Nvidia Optimus is a good example of how these complex, interwoven systems with their complex drivers need thorough benchmarking in a non trivial "zero CPU time with GL compositing" way. Throw in some video encoding\decoding, networking or even OpenCL and you get some surprises to be sure.
Everybody seems to forget that when people look for something "lightweight", their true goal is rarely to "minimize CPU usage" or to "minimize memory usage". CPU and mem usage are just indirect indicators of qualities that are much harder to measure objectively/accurately but are in correlation with CPU and mem: response time and battery time. Responsiveness and longer battery times are the what users really want. The linked article makes a single but fatal flaw, in that it argues that compositing is just a memory/cpu tradeoff, but it forgets that users actually want a more responsive and more power-efficient system and that these do not only depend on the CPU and memory.
I have a long experience in 3D game programming, and here is a fact that I can tell you about. Data transfers between CPU and GPU are bad, coz they are inherently slow. This is the sole reason that in the early days of 3D, screen-space effects (like blurs), environmental mapping (used for reflections and mirrors) and many other effects were used rarely: they were extremely slow because data had to be downloaded from the GPU to CPU and then back to the GPU, which used to be slow.
What does this mean for compositing? Sure, with OpenGL compositing the CPU can sleep more and the GPU can work more power-efficiently on the pixels than the CPU could. But bus transfer times can seriously limit responsiveness on old hardware or crappy drivers, for the same reason that on old hardware such effects killed your FPS from 40 to 5 in games. Coz (and correct me if I'm wrong, I'm not an expert on x11 and internals of GUI toolkits), I'm reasonably sure that GTK and classic Qt render most of their stuff on the CPU. So any time an application changes its window contents, data has to be sent over to the GPU from the CPU, possibly killing your compositing framerate.
I know, I've been talking about older hardware, so does this have any relevance today? It could. For games, said issues have been solved to some extent: data exchange between CPU and GPU is still bad, but games can use such effects more freely now, because 1) graphics buses have gotten faster, 2) GPU hardware and drivers implemented support of making textures out of GPU-rendered frames without having to download them to the CPU first, and 3) games started to use these driver features. For desktop compositing, since most rendering is done on the CPU, such "advanced" driver features cannot be used, which leaves us on the slow side. Not to mention, if your GPU driver falls back to CPU rendering for many things, then compositing is more likely than not a large and negative hit on performance. Otherwise, the effect on responsiveness will depend on the hardware, the quality of the drivers and the rendering mechanisms used by the GUI toolkit. Compositing is likely a win for the battery if your HW/driver is good enough though.
What to take home, IMHO? This long post was merely intended to point out that the "lightweigthedness" of compositing is a much more complex issue than just CPU/memory trade-off, so the original article is very shallow, pointless and I could say even misleading. Compositing could equally slow down or speed up your system based on many factors, and it might not even have anything to do with CPU or memory. So here is what you should do if you are concerned about the question of compositing efficiency on *your* system: Try it out, and if by experience you feel it slows down your system, turn it off. Otherwise, leave it on.
Last edited by ultimA; 05-01-2013 at 04:41 PM.


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text:
Major Section: ACL2 Documentation
ACL2 allows the user to monitor the application of rewrite rules.
When monitored rules are about to be tried by the rewriter, an
interactive break occurs and the user is allowed to watch and, in a
limited sense, control the attempt to apply the rule. This
interactive loop, which is technically just a call of the standard
top-level ACL2 read-eval-print loop, ld
, on a ``wormhole state''
(see wormhole), is called ``break-rewrite.'' While in
break-rewrite, certain keyword commands are available for accessing
information about the context in which the lemma is being tried.
These keywords are called break-rewrite ``commands.''
Also see dmr (Dynamically Monitor Rewrites) for a related utility, which allows you to watch progress of the rewriter in real time.
To abort from inside break-rewrite at any time, execute
For further information, see the related :
topics listed below.
As explained in the documentation for monitor
, it is possible to
cause the ACL2 rewriter to monitor the attempted application of
selected rules. When such a rule is about to be tried, the rewriter
evaluates its break condition and if the result is non-nil
break-rewrite is entered.
Break-rewrite permits the user to inspect the current state by
evaluating break-rewrite commands. Type :
in break-rewrite to
see what the break-rewrite commands are. However, break-rewrite is actually
just a call of the general ACL2 read-eval-print loop, ld
, on a certain
state and the break-rewrite commands are simply aliases provided by
table (see ld-keyword-aliases). See ld for
details about this read-eval-print loop. Thus, with a few exceptions,
anything you can do at the ACL2 top-level can be done within break-rewrite.
For example, you can evaluate arbitrary expressions, use the keyword command
hack, access documentation, print events, and even define functions
and prove theorems. However, the ``certain state'' upon which ld
was called is a ``wormhole state'' (see wormhole) because
break-rewrite is not allowed to have any effect upon the behavior of rewrite.
What this means, very roughly but understandably, is that break-rewrite
operates on a copy of the state being used by rewrite and when
break-rewrite exits the wormhole closes and the state ``produced''
by break-rewrite disappears. Thus, break-rewrite lets you query the state of
the rewriter and even do experiments involving proofs, etc., but these
experiments have no effect on the ongoing proof attempt. In particular:
Note that the output from break-rewrite is sometimes abbreviated by default,
such as for the term causing the break. This can be controlled by setting
the :term
evisc-tuple; see set-evisc-tuple. (Another option: use
iprinting. See set-iprint.) But as noted above, if you use
from inside the break-rewrite wormhole, its effect
will disappear when you exit the break. So you might want to issue a
command from the top level, outside break-rewrite.
When you first enter break-rewrite a simple herald is printed such as:
(3 Breaking (:rewrite lemma12) on (delta a (+ 1 j)):The integer after the open parenthesis indicates the depth of nested break-rewrite calls. In this discussion we use
consistently for this integer. Unless you abort or somehow enter
unbalanced parentheses into the script, the entire session at a
given depth will be enclosed in balanced parentheses, making it easy
to skip over them in Emacs.You then will see the break-rewrite prompt:
3 ACL2 !>The leading integer is, again, the depth. Because breaks often occur recursively it is convenient always to know the level with which you are interacting.
You may type arbitrary commands as in the top-level ACL2 loop. For example, you might type:
3 ACL2 !>:helpor
3 ACL2 !>:pe lemma12More likely, upon entering break-rewrite you will determine the context of the attempted application. Here are some useful commands:
3 ACL2 >:target ; the term being rewritten 3 ACL2 >:unify-subst ; the unifying substitution 3 ACL2 >:path ; the stack of goals pursued by the rewriter ; starting at the top-level clause being simplified ; and ending with the current applicationAt this point in the interaction the system has not yet tried to apply the monitored rule. That is, it has not tried to establish the hypotheses, considered the heuristic cost of backchaining, rewritten the right-hand side of the conclusion, etc. When you are ready for it to try the rule you can type one of several different ``proceed'' commands. The basic proceed commands are
, :go
, and
:okexits break-rewrite without further interaction. When break-rewrite exits it prints ``
'', closing the parenthesis that
opened the level 3
:goexits break-rewrite without further interaction, but prints out the result of the application attempt, i.e., whether the application succeeded, if so, what the
term was rewritten to, and if not
why the rule was not applicable.
:evalcauses break-rewrite to attempt to apply the rule but interaction at this level of break-rewrite resumes when the attempt is complete. When control returns to this level of break-rewrite a message indicating the result of the application attempt (just as in
) is
printed, followed by the prompt for additional user input.Generally speaking, :ok
and :go
are used when the break in question
is routine or uninteresting and :eval
is used when the break is one
that the user anticipates is causing trouble. For example, if you
are trying to determine why a lemma isn't being applied to a given
term and the :target
of the current break-rewrite is the term in
question, you would usually :eval
the rule and if break-rewrite
reports that the rule failed then you are in a position to determine
why, for example by carefully inspecting the :type-alist
governing assumptions or why some hypothesis of the rule could not
be established.
It is often the case that when you are in break-rewrite you wish to
change the set of monitored runes. This can be done by using
and :
as noted above. For example, you might want
to monitor a certain rule, say hyp-reliever
, just when it is being
used while attempting to apply another rule, say main-lemma
Typically then you would monitor main-lemma
at the ACL2 top-level,
start the proof-attempt, and then in the break-rewrite in which
is about to be tried, you would install a monitor on
. If during the ensuing :eval
is broken
you will know it is being used under the attempt to apply
However, once hyp-reliever
is being monitored it will be monitored
even after main-lemma
has been tried. That is, if you let the proof
attempt proceed then you may see many other breaks on hyp-reliever
breaks that are not ``under'' the attempt to apply main-lemma
. One
way to prevent this is to :eval
the application of main-lemma
then :
before exiting. But this case arises
so often that ACL2 supports several additional ``flavors'' of
proceed commands.
, :go!
, and :eval!
are just like their counterparts
, :go
, and :eval
, respectively), except that while
processing the rule that is currently broken no runes are
monitored. When consideration of the current rule is complete,
the set of monitored runes is restored to its original
, :go$
, and :eval$
are similar but take an additional argument
which must be a list of runes. An example usage of :eval$
3 ACL2 !>:eval$ ((:rewrite hyp-reliever))These three commands temporarily install unconditional breaks on the runes listed, proceed with the consideration of the currently broken rule, and then restore the set of monitored rules to its original setting.
Thus, there are nine ways to proceed from the initial entry into
break-rewrite although we often speak as though there are two, :ok
and :eval
, and leave the others implicit. We group :go
with :ok
because in all their flavors they exit break-rewrite without further
interaction (at the current level). All the flavors of :eval
require further interaction after the rule has been tried.
To abort a proof attempt and return to the top-level of ACL2 you may at any
time type (a!)
followed by a carriage return. If you are not in a raw
Lisp break, you may type :a!
instead. The utility p!
is completely
analogous to a!
except that it pops up only one ld
level. If you
have just entered the break-rewrite loop, this will pop you out of that loop,
back to the proof. See a! and see p!.
We now address ourselves to the post-:eval
interaction with
break-rewrite. As noted, that interaction begins with
break-rewrite's report on the results of applying the rule: whether
it worked and either what it produced or why it failed. This
information is also printed by certain keyword commands available
after :eval
, namely :wonp
, :rewritten-rhs
, and :failure-reason
. In
addition, by using brr@
(see brr@) you can obtain this
information in the form of ACL2 data objects. This allows the
development of more sophisticated ``break conditions'';
see monitor for examples. In this connection we point out the
macro form (ok-if term)
. See ok-if. This command exits
break-rewrite if term
evaluates to non-nil
and otherwise does not
exit. Thus it is possible to define macros that provide other kinds
of exits from break-rewrite. The only way to exit break-rewrite
after :eval
is :ok
(or, equivalently, the use of ok-if
ACL2 users who wish to know more about break-rewrite so that they can develop more convenient ways to monitor rules are encouraged to speak to J Moore.
The rest of this documentation discusses a few implementation details of break-rewrite and may not be interesting to the typical user.
There is no ACL2 function named break-rewrite. It is an illusion
created by appropriate calls to two functions named brkpt1
. As previously noted, break-rewrite is ld
operating on a
wormhole state. One might therefore wonder how break-rewrite can
apply a rule and then communicate the results back to the rewriter
running in the external state. The answer is that it cannot.
Nothing can be communicated through a wormhole. In fact, brkpt1
are each calls of ld
running on wormhole states. Brkpt1
implements the pre-:eval
break-rewrite and brkpt2
implements the
break-rewrite. The rewriter actually calls brkpt1
attempting to apply a rule and calls brkpt2
afterwards. In both
cases, the rewriter passes into the wormhole the relevant
information about the current context. Logically brkpt1
and brkpt2
are no-ops and rewrite
ignores the nil
they return. But while
control is in them the execution of rewrite
is suspended and cannot
proceed until the break-rewrite interactions complete.
This design causes a certain anomoly that might be troubling.
Suppose that inside break-rewrite before :evaling
a rule (i.e., in
the brkpt1
wormhole state) you define some function, foo
. Suppose
then you :eval
the rule and eventually control returns to
break-rewrite (i.e., to brkpt2
on a wormhole state with the results
of the application in it). You will discover that foo
is no longer
defined! That is because the wormhole state created during your
interaction is lost when we exit the wormhole to resume
the proof attempt. The post-:eval
wormhole state is in fact
identical to the initial pre-:eval
state (except for the results of
the application) because rewrite
did not change the external state
and both wormhole states are copies of it. A similar issue occurs
with the use of trace utilities: all effects of calling trace$
are erased when you proceed from a break in the break-rewrite
There is a lot more to know about break-rewrite, most of which is fairly easy to learn from looking at the code, since it is all expressed in ACL2. Feel free to ask questions of J Moore.


text:
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text:
It occurs to me that gemming has become very boring these days. It's pretty much choose the best stat for your class and stack it.
When jewelcrafting was first released, it seemed much more exciting. There were all these colors of gems, with different colours of sockets, different socket bonuses, and meta-gems with interesting requirements.
Pretty much all of that has been bled from the system. Socket colours are pretty much ignored. The different types of socket bonuses have disappeared, replaced for most classes by a single stat. For example, on plate DPS armor, the socket bonus is always strength. It's the only stat that can possibly tempt someone away from mono-coloured gems. Meta-gem requirements have been reduced to the bare minimum. And even that is not enough. The meta-gems which require 1 of each color are considered much better than the meta-gems which require 2 blues, because you can use only 1 Nightmare Tear and meet the meta-gem requirements.
As well, I'm not sure being able to focus so much of your item budget on your single-best state is good for the game. It allows for an extremely wide range of that one ability. For example, the health difference between a tank stacking all stamina gems and one matching socket colors is very noticeable.
Is there a way to make gemming interesting once again, and maybe also rein it in a bit?
My suggestion would be to remove single-color gems. If all gems are dual-colors, then it might be easier to hit the socket bonuses. You can't focus so much in the same way. The choice becomes not so much between best stat and second-best stat, it's between second-best stat and third-best stat. Oftentimes, that's enough wiggle room to make decision-making interesting again.
In my opinion, sometimes offering the best possible choice as an option is not the best way to go. Making a decision between two flawed choices can be more interesting.
Monday, June 28, 2010
Single-Colour Gems
22 comments:
- Dwism said...
Oh I really like that. Sounds very similar to what they are trying to do with medium sized glyphs.
- 11:58 PM, June 28, 2010
- Anonymous said...
When I look at the "EH" gemming strategy for tanks I get really sad. It seems really boring and unoriginal.
- 12:05 AM, June 29, 2010
- johnliu.net said...
I actually disagree with the statement that gemming has gotten boring.
It is only boring because players don't want to tweak gems once they got it ... 80% there.
Same goes with Inscription. Very few players actually switch glyphs between encounters. Why don't they? a stack of glyphs only costs 10g in raw materials.
Tanking gems are extremely fun. When you get a new piece that has extra defense on it, do you re-gem and put the extra stats somewhere else?
When ICC buffs increase yet another 5%, do you switch gems to have higher threat?
When RET paladins get their 2pT10 bonus, do they switch over to haste?
If players are too lazy to actually tweak their gems - it's not the system's fault.
Oh another thought:
1 Runed = 23 Spell Power
1 Quick King's Amber = 20 haste
For the same two slots:
2 Reckless Ametrine = 24 Spell Power, 20 haste. - 12:32 AM, June 29, 2010
- Sharlos said...
I don't see how that will change anything. There will still be an optimum gem to use, even if it is less of a dps increase than the current ones used. The only way I can see a way to change it is by increasing the socket bonus you get by fulfilling the socket requirements.
- 1:05 AM, June 29, 2010
- failadin said...
Yeah I like that. It does seem to trivial to gem "properly" nowadays, especially for Holy paladins. There are exceptions of course, but still.
- 2:16 AM, June 29, 2010
- Anonymous said...
Well, there is a "the best" dual-color gem too, in most cases.
For now, shadow priests gem Runed Cardinal Rubies, Reckless Ametrines (when socket bonus is profitable enough) and Purified Dreadstones (exactly 2 to activate the metagem).
If Cardibal Rubies would suddenly disappear, there will be Reckless Ametrines all over with a pair of Purified Dreadstones.
No other type of Ametrine will be used, and Eyes of Zul will not appear at all.
This is DPS gemming for you. More DPS = better gem.
Of course, healer gems will be more varied. But they already are. - 4:39 AM, June 29, 2010
- Matt said...
The problem isn't single color gems, its that either the socket bonuses aren't good enough by themselves, or your lose more gemming for them then just using a single color.
As an example, on my ret pally, if an item has a blue socket in it, but the socket bonus is good, I'll either use a nightmare tear, or just ignore the socket bonus. If the item has no blue sockets but red and one yellow, I might gem str/crit or str/hit if the bonus is 4str or higher. This depends on my current gear though. - 6:06 AM, June 29, 2010
- Matt said...
As for choosing between two suboptimal choices. This is worse for an average player then choosing between one optimal and one bad choice. This is because the choice is usually unintutive, and usually requires use of a spreadsheet to determine the best solution. An example of this would be a plate piece with armor pen on it. or a leather piece. Both have suboptimal stats, but its difficult to tell in a qualatative manner. This requires a spreadsheet to make the determination in a quanatative manner.
- 6:06 AM, June 29, 2010
- Mike said...
I think the solution here is to remove socket bonuses entirely and just require the correct colored gem for the socket. No red gems in blue sockets for instance. They could make meta-style sockets in regular equipment that take any gem color for some extra variety.
- 6:19 AM, June 29, 2010
- Dorgol said...
I 100% agree that stacking a single gem regardless of socket bonus is boring. So I don't do it.
My Warlock has more Purified gems than Runed gems. My Warrior has Dodge + Stam and Defense + Stam (even though I'm over the Defense cap). My Paladin has Stam + Str gems!
In all, though, I'm happy with the system the way it is now. Players have a choice of what gems to use. Those that insist on min-max-or-die can stack one gem in all slots and get an extra 20 strength on their gear. Those (like me) who would prefer to not see those greyed out bonuses get to match colors. - 7:23 AM, June 29, 2010
- Christian Griffin said...
Johnliu, just thought I would mention that no, we ret paladins do not switch over to haste for our T10 2P bonus, because in all frankness its a terrible bonus unless we want to focus on really taking down that trash mob fast. It provides little to no advantage on bosses - as a matter of fact, it can occasionally LESSEN our DPS.
- 7:28 AM, June 29, 2010
- Anise said...
They could make the same change if they increased the stats by a small amount on the multicolored gems.
Right now, solid colors are +20 and mixed colors are +10/+10. If you just made it +20 for solid and +12/+12 for mixed color you would mtake a much larger bite out of the strat for stacking a single stat. - 7:29 AM, June 29, 2010
- loveandwarinazeroth said...
Am I the only person in the world who is so anal retentive that I can't not get the socket bonus for my gems? I know it's crazy and probably counter-productive insofar as min/maxing goes, but it troubles me to see socket bonuses not utilized. I'm the crazy fool buying the green and purple gems for my blue sockets. Stupid blue sockets.
- 7:29 AM, June 29, 2010
- Codi said...
I don't think that would help at all. For healadins, instead of all yellow INT gems, we'd just move on to all green INT/MP5 gems. It wouldn't make gemming something else more viable, it would just change the optimum gemming strat to a specific two color gem.
- 7:56 AM, June 29, 2010
- Redbeard said...
What I'd like to see in terms of gem changes is reducing access to the Epic gems. On the three servers I'm on, the difference between the raw epics and the cut ones is about 10-30G, not really enough to make JC a skill. Maybe alchemy plus JC, so that you buy the rare gems (or the ore and prospect) and convert them to epics, but that's about it.
- 8:04 AM, June 29, 2010
- Klepsacovic said...
This could make things more interesting, but I fear we'd just establish a new standard of boring once we've theorycrafted the second best and third best. We'd be more colorful, but would we really be more interesting?
@johnliu.net: What's there to tweak? Few tanks need to gem for defense, so getting more defense on an item isn't going to make them change any gems. Whatever marginal gain they get won't be worth the 100-200g per gem. As for 2t10 or similar 'transformative' bonuses, how many yellow gems is the average ret using that could be replaced anyway?
@Christian Griffin: How would getting our second highest damage attack reset lower our DPS? As long as we're still keeping up judgement for regen and not letting the CS libram buff fall off, how could more DS be worse? - 8:20 AM, June 29, 2010
- Bronte said...
Oh I can attest to this. My Holy Paladin has +Intellect gems socketed to the rafters, regardless of which color the slot is. I think part of the problem is that the socket bonuses are incredibly weak. If I have the choice between the most important stat for my class, and +3 to mp/5 for socketing a "proper" color, that isn't even a choice for me. I will sacrifice the underwhelming socket bonus without second thought.
- 9:02 AM, June 29, 2010
- Sky said...
Christian Griffin:
Consult a spreadsheet or theorycrafting source before passing around faulty information please. 2t10 is an substantial dps increase on a single target, something on the order of 4%, which is actually significantly higher than many other classes' 2t10. You can easily see the effects by building a rotation simulator and a priority list and watching how many more DS hits you get in.
I recommend Redcape's Retribution Spreadsheet (largely because I am the author), but Exemplar's sheet or Rawr will back my claims up. You can find the information and links at http://elitistjerks.com/f76/t68951-retribution_updated_3_3_a/#Tools_and_faqs - 9:32 AM, June 29, 2010
- Green Armadillo said...
I'm with Klep - if you take out single-color gems, each spec will simply switch to stacking the optimal multi-color gem. This might make items with fewer sockets more viable, but that won't make gemming more interesting. Nor will improving socket bonuses or making more powerful meta gems. In the end, there will always be a best option.
- 10:58 AM, June 29, 2010
- Lanashara of Khaz'Goroth said...
I agree with Mike...
"I think the solution here is to remove socket bonuses entirely and just require the correct colored gem for the socket.
That would handle it. No need to even remove the single colors. More fun that way. - 2:22 PM, June 29, 2010
- Hairymuppet said...
Maybe the socket bonus could scale with the quality of gems socketed? It seems like the socket bonuses atm are only too low because they're being compared with epic gems... compared with uncommon gems they are quite decent.
- 4:53 PM, June 29, 2010
- Mick said...
Given the high level of stats on gear, and the ICC buff, gemming and enchanting is becoming less and less of an issue then it was when Wraith forst dropped.
All it is now is an indication that you know what you're doing. If you don't stam stack and instead go for hit/exp to get your threat up to out-compete meter hungry dps, you miss maybe 100-150 stam? Given the icc buff, why do people still stam stack? - 6:33 PM, July 10, 2010