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Picaud, S., Strocchia, M., Terracciano, S., Lauro, G., Mendez, J., Daniels, D.L., Riccio, R., Bifulco, G., Bruno, I. and Filippakopoulos, P.
Notes: The authors used bioluminescence resonance energy transfer (BRET) to test the ability of a bromodomain 9 ligand to disrupt binding to histone. HEK 293 cells were cotransfected with a histone H3.3-HaloTag® fusion vector and either NanoLuc®-BRD9 bromodomain or NanoLuc®-full-length BRD4 fusion vector. After 24 hours, the transfected cells were trypsinized, diluted in phenol red-free DMEM with or without 10nM of HaloTag® NanoBRET™ 618 Ligand and dispensed into a 96-well plate. One of two potential BRD-disrupting compounds, 7d or 11, was adding to a final concentration of 0.005–33μM, cells were incubated for 18 hours and NanoBRET™ Nano-Glo® Substrate (final concentration 10µM) was added. Fluorescence was measured and a corrected BRET ratio calculated. Cytotoxicity was assessed after the NanoBRET™ assay by incubating the cells with the CellTiter-Glo® Reagent for 30 minutes and measuring luminescence. To examine histone H3.3 localization, HEK 293 cells were transfected with the histone H3.3-HaloTag® fusion vector using FuGENE® HD Transfection Reagent. After 24 hours, cells were labeled with 5μM HaloTag® TMR ligand for 15 minutes before washing with complete medium, incubated for 30 minutes and imaged with a confocal microscope. (4568)
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NanoBRET™ Nano-Glo® Substrate
NanoBRET™ Nano-Glo® Detection System
HaloTag® NanoBRET™ 618 Ligand
FuGENE® HD Transfection Reagent
CellTiter-Glo® Luminescent Cell Viability Assay
HaloTag® TMR Ligand
Expand Products »
Urh, M., and Rosenberg, M.
Notes: This paper provides an overview of the many applications of HaloTag® Technology. The authors describe the development of the technology, focusing on it's multifunctional utility for protein imaging, protein isolation and display, and in the study of protein complexes and interactions. They also discuss it's potential to facilitate proteomics research studies across complex biological systems at the biochemical, cell-based and whole animal level. (4325)
HaloTag® Protein Purification System Sample Pack
HaloTag® Protein Purification System
HaloTag® Mammalian Protein Detection and Purification System
HaloTag® Mammalian Pull-Down and Labeling System
HaloTag® Mammalian Pull-Down System
HaloTag® diAcFAM Ligand
HaloTag® Biotin Ligand
Yuanzheng, H., Xu, Y., Zhang, C., Gao, X., Dykema, K.J., martin, K.R., Ke, J., Hudson, E.A., Khoo, S.K., Resau, J.H., Alberts, A.S., Mackeigan, J.P., Furge, K.A. and Xu, H.E.
Notes: Yuangheng He and colleagues asked how the weak alkaline compound chloroquine (CQ) enhances the anti-inflammatory effects of synthetic glucocorticoids like dexamethasone, which are used to treat a host of inflammatory and autoimmune diseases. In the process they explored the intersection of lysosomal degradation pathways and glucocorticoid receptor signaling. They used Dual-Glo® Luciferase Assay System to look at glucocorticoid receptor-mediated (GR) activation and repression of reporters in AD293 cells under a variety of conditions (presence or absence of CQ; stripped serum, loss of lysosome synthesis, inhibition of V-ATPase, etc). They also used HaloTag® protein fusions to observe the fate of GR populations in the presence or absence of CQ and in the presence or absence of compounds that impair proteasome function. Live-cell imaging of GR-HaloTag® protein fusions revealed a dynamic association of the GR with lysosomes. The authors showed that glucocorticoid signaling is regulated by lysosomes. (4203)
Dual-Glo® Luciferase Assay System
Maruyama, A., Nishikawa, K., Kawatani, Y., Mimura, J., Hosoya, T., Harada, N., Yamamato, M. and Itoh, K.
Notes: These authors first used a FLAG-tagged protein (nfr2) with a HeLa Nuclear extract and captured interacting proteins via SDS-PAGE and in-gel digests of bands to identify (Krüppel-associated box)-associated protein 1 (KAP1) as a potential interacting partner. Human KAP1 was purchased as a HaloTag® CMV Flexi® Vector from Kazusa and used in a Mammalian PullDown scenario (with HaloLink™ Resin) to demonstrate interaction between the two proteins. A reporter assay was used to show that KAP1 facilitates Nrf2 transactivation in a dose-dependent manner. The authors defined the interaction sites using GST-tagged nrf2 and various forms of KAP1-HaloTag® Fusions expressed in TNT® SP6 High-Yield Wheat Germ Extract. GST-tagged proteins were expressed in E. coli and bound to glutathione-Sepharose beads. These bound proteins were mixed with the KAP1 from the cell-free expression system, incubated for 4 hours at 4°C, washed and stained with the HaloTag® TMR Ligand for 30 minutes. The proteins from the pull-down assay were subjected to SDS-PAGE and the HaloTag® proteins detected by phosphorimaging and the GST proteins by Coomassie Brilliant Blue Staining. A two-hybrid system consisting of the pRL-TK Vector with a firefly luciferase reporter with Gal4 UAS, mouse Nrf-2 N-terminal domain and KAP1 was also used. The vectors were transfected into Nrf2 knockout MEFs for 4 hours then incubated for 36 hours before luciferase expression was determined using the Dual-Luciferase® Reporter Assay System. (4123)
Anti-HaloTag® pAb
Dual-Luciferase® Reporter Assay System
pFN21A HaloTag® CMV Flexi® Vector
pGEM®-T Easy Vector System I
pGEM®-T Easy Vector System II
pGL3-Basic Vector
pRL-TK Vector
Hasegawa, Y., Honda, A., Umezawa, K., Niino, Y., Oka, K., Chiba, T., Aiso, S., Tanimoto, A., Citterio, D., and Suzuki, K.
Notes: These authors describe a method for cell-surface labeling with two genetically expressed tags, a biotin acceptor peptide (BAP) and HaloTag (HT). BAP and HT were fused with the N-terminus of the mouse Ig κ-chain leader sequence to direct them to the secretory pathway, and the c-terminus of the platelet-derived growth factor receptor transmembrane domain to anchor them to the plasma membrane. Fluorescent proteins were fused with BAP and HT to create the two distinct fluorescent transmembrance proteins BAP-YFP-TM and HT-CFP-TM. The constructs were introduced into HeLa cells and imaged simultaneously. The authors then demonstrated in vivo imaging by injecting the doubly-tagged HeLa cells into nude mice and imaging with near infrared fluorescent probes, and with magnetic resonance probes. (3998)
HaloTag® Alexa Fluor® 488 Ligand
Schröder, J. Benink, H., Dyba, M. and Los, G.V.
Notes: Traditionally light microscopy resolution has been limited by the diffraction of light. However several new technologies have emerged that partially overcome that limitation. One of these stimulated emission depletion (STED) microscopy is now commercially available and has been integrated into confocal microscope platforms. Because STED depends on fluorescent markers that fulfill specific spectroscopic needs, its uses have been limited. The authors of this paper demonstrate successful high resolution of β1-integrin-Halotag®-fusion protein distribution using STED microscopy. Use of the HaloTag® technology allows researchers to create a reporter that can be labeled with STED-optimized fluorescent tags. (3955)
Hurst, R., Hook, B., Slater, M.R., Hatrnett, J., Storts, D.R., and Nath, N.
Notes: These authors compared 6 different detection strategies for protein-protein interactions on protein arrays. They expressed HaloTag® labeled bait proteins in a cell-free expression system, and captured these bait proteins onto coated glass slides using the HaloLink™ Array System. They then compared detection strategies using prey proteins labeled as follows: 1)35S methionine, 2) fluorescence (BODIPY-FL) and 3) biotin labeling of lysine residues using modified Lys tRNA, 4) chemical labeling after expression, 5) HaloTag® fusion, and 6) N-terminal FLAG tag. The authors evaluated signal:background ratios, adaptability to high-throughput screening, and ease of use. (3999)
pF1A T7 Flexi® Vector
HaloLink™ Array (TnT® SP6 Wheat Germ) Two Slide System
TnT® SP6 Quick Coupled Transcription/Translation System, Trial Size
FluoroTect™ GreenLys in vitro Translation Labeling System
Transcend™ tRNA
Kei Yamaguchi, Shinichi Inoue, Osama Ohara and Takahiro Nagase
Notes: The authors used the Halotag® Labeling Technology in pulse-chase experiments. They pulse labeled proteins in cultured mammalian cells. Using the HaloTag® Technology, they were able to monitor the degradation of the labeled protein, Smad1, that was induced by coexpression of Smurf1. They conclude that the HaloTag® Technology could be used to monitor the regulation of SMAD1 degradation. (4055)
HaloTag® Succinimidyl Ester (O4) Ligand
HaloTag® TMRDirect™ Ligand
Kardon, J.R., Reck-Peterson, S.L. and Vale, R.D.
Notes: These authors expressed recombinant dynactin and dynein in Saccharomyces cerevisiae and investigated their interactions in motility assays. They created a c-terminal Halotag-Dynactin fusion, and were able to site-specifically label the fusion protein with the fluorescent dye tetramethylrhodamine (TMR). They studied the effect of the purified dynactin fusion protein on the motility of dynein complexes using total internal reflection fluorescence micropscopy. Dynactin alone did not interact with microtubules. However, when coincubated with recombinant dynein, the TMR-labeled dynactin moved processively along microtubules. The authors then used truncation mutants of dynactin to identify the region of the dynactin molecule required for localization and enhanced processivity of dynein. (3960)
Ogawa, M., Shinohara, H., Sakagami, Y. and Matsubayashi, Y.
Notes: The authors of this study investigated the role of the genes CLV1 and CLV3 stem cell renewal and differentiation in self-renewing shoot apical meristem (SAM) in Arabidopsis. CLV1 encodes a receptor kinase that is a negative regulator of cell growth, and therefore cannot be overexpressed in plant cells. CLV3, which encodes a protein that is processed to a 12-amino acid peptide, is believed to be a ligand for CLV1. In this study, the authors made a construct in which the CLV1 kinase domain was replaced with the HaloTag™ protein and expressed the fusion protein in tobacco BY-2 cells. The fusion protein was detected using the HaloTag™ TMR ligand. They next incubated membrane extracts from wildtype and transgenic BY-2 cells (expressing the HaloTag™-CLV1 fusion) with tritium-labeled CLV3. The transgenic cells showed significantly higher CLV3 binding than wildtype, and the authors show that CLV3 specifically labels a 130-kd band that corresponds to the HaloTag™-CLV1 fusion protein, indicating that CLV3 binds the ectodomain of CLV1. (3763)
Los, G.V., Encell, L.P., McDougall, M.G., Hartzell, D.D., Karassina, N., Zimprich, C., Wood, M.G., Learish, R., Ohana, R.F., Urh, M., Simpson, D., Mendez, J., Zimmerman, K., Otto, P., Vidugris, G., Zhu, J., Darzins, A., Klaubert, D.H., Bulleit, R.F., and Wood, K.V.
Notes: The authors of this study describe a reporter gene system that allows researchers to create one genetic construct that can be used for a variety of studies including imaging and protein imobilization. The HaloTag® reporter protein is engineered to form covalent bonds with ligands that have different functional reporters. (3925)
HaloLink™ Resin
HaloTag® Amine (O2) Ligand
HaloTag® Amine (O4) Ligand
HaloTag® Coumarin Ligand
HaloTag® Iodoacetamide (O2) Ligand
HaloTag® Iodoacetamide (O4) Ligand
HaloTag® Oregon Green® Ligand
HaloTag® PEG-Biotin Ligand
HaloTag® Succinimidyl Ester (O2) Ligand
HaloTag® Thiol (O4) Ligand
Tatematsu, K., Yoshimoto, N., Okajima, T., Tanizawa, K., and Kuroda, S.
Notes: RBCK1 is a RING-IBR (ring in between ring fingers) protein previously shown to have transcriptional activity and to bind protein Kinase Cβ. This paper demonstrates that RBCK1 also posseses ubiquitin ligase E3 activity. Both FLAG-tag and HaloTag® labeled proteins were used to demonstrate this activity. To demonstrate the interaction between RBCK1 and ubiquitinated proteins, HaloTag®-ubiquitin and FLAG-RBCK1 were coexpressed in HEK293 cells in the presence or absence of a proteasome inhibitor. The anti-FLAG immunoprecipitates isolated from these cells were analyzed by SDS-PAGE and Western blotting using anti-HaloTag® and anti-FLAG antibodies and self-ubiquitination of RBCK1 was demonstrated. RBCK2, a splice variant of RBCK1 lacking the RING domain showed no self ubiquitination activity but was demonstrated to interact with RBCK1 in vivo and in vitro, and to inhibit the self-ubiquitination activity of RBCK1 in a FLAG-tag assay. Pulse-chase experiments, using HEK293 cells expressing HaloTag®-RBCK1 with or without RBCK2 and treated with HaloTag®-TMR ligand, were used to show that the half-life of RBCK1 was extended by overexpression of RBCK2. (3874)
Svendsen, S., Zimprich, C., McDougall, M.G., Klaubert, D.H., and Los, G.V.
Notes: This paper demonstrates use of HaloTag® technology to study expression, trafficking and translocation of an integrin-HaloTag® fusion protein. The authors fused the Halotag reporter protein to truncated integrin. They then labeled live cells with different cell-permaent and impermeant ligands and followed spatial separation of plasma membrane and internal pools of the integrin-HaloTag® protein. (3912)
Shinohara, H. and Matsubayashi, Y.
Notes: The authors were looking for a method for ligand fishing experiments with plant receptor-like kinases (RLKs). The strategy chosen, functional immobilization on microbeads, used phytosulfokine (PSK) and its carrot cell receptor (DcPSKR1) as the test ligand-receptor pair. DcPSKR1 was cloned into the pHT2 HaloTag® Vector, adding the HaloTag® gene to the C terminus of DcPSKR1 or replacing the DcPSKR1 kinase domain. These constructs were transfected into BY-2 cells and expression confirmed by immunoblotting the membrane fraction and staining with DcPSKR1 and Anti-HaloTag antibodies. To confirm activity of the individual proteins, membrane fractions of BY-2 cells expressing the DcPSKR1-HaloTag® fusion proteins were tested for PSK binding activity to then HaloTag® binding activity confirmed using the HaloTag® TMR Ligand. The DcPSKR1-ΔKD-Halo protein was immobilized on HaloLink™ Resin and the Kd measured. The binding of PSK to the immobilized DcPSKR1-ΔKD-Halo protein was visualized by using fluorescently labeled Alexa488-PSK. Columns of HaloLink™ Resin with bound DcPSKR1-ΔKD-Halo protein were used to bind PSK ligands at physiological concentration, elute the ligands with a high-salt buffer and analyzed on LC-MS. (3946)
Straszewshi-Chavez, A., Visintin, I.P., Karassina, N., Los, G., Liston, P., Halaban, R., Fadiel, A. and Mor, G.
Notes: The authors sought to determine the mechanism by which first-trimester trophoblasts resist FAS ligand-induced apoptosis but remain sensitive to TNFα-mediated apoptosis. First trimester trophoblasts express XAF1 [X-linked inhibitor of apoptosis (XIAP)-associated factor 1], which may be involved in regulating their response to proapoptotic signals. The authors created HaloTag™-XAF1 fusion constructs and transiently transfected the first trimester trophoblast cell line (3A). Cells were labeled with the HaloTag™ TMR ligand, and XAF1 was shown to localize to the cytoplasm. 3A cells transiently transfected with the fusion construct were also separated into cytoplasmic and mitochondrial fractions. The fractions were labeled with HaloTag™ TMR ligand. Expression of the fusion peaked at 48 hours after transfection in both mitochondrial and cytoplasmic fractions. TNFα-treatment of 3A cells induced translocation of endogenous XAF1 to the mitochondria. The authors used the Caspase-Glo® Assays to demonstrate activation of caspase-3 and caspase-9 in response to expression of XAF-1. They also show that caspase-3 activation and XIAP cleavage correlate with translocation of endogenous XAF1 to mitochondria. Viability of 3A and primary trophoblasts over expressing XAF1 was evaluated using the CellTiter® 96 AQueous One-Solution Assay. (3760)
Caspase-Glo® 3/7 Assay
Caspase-Glo® 9 Assay
CellTiter 96® AQueous One Solution Cell Proliferation Assay
Lang, C., Schulze, J., Mendel, R-R. and Hänsch, R.
Notes: This paper highlights the first use of the HaloTag™ Interchangeable Protein Labeling Technology in plant cells. The cDNA for the HaloTag™ protein was amplified by PCR from the pHT2 Vector and cloned into the pGEM®-T Easy® Vector, from which it was excised and transferred to a second vector where its expression was under the control of the cauliflower mosaic virus (CaMV)-35S promoter. The construct was transformed into tobacco protoplasts and bioballistically transformed into tobacco leaf cells. Localization was followed using the HaloTag™ TMR and diAcFAM Ligands. (3503)
Reck-Peterson, S.L., Yidiz, A., Carter, A.P., Gennerich, A., Zhang, N. and Vale, R.D.
Notes: HaloTag™ Interchangeable Labeling Technology was used to specifically label engineered dynein produced in Saccharomyces cerevisiae. The HaloTag™ Protein was added in-frame with either the 5´ or 3´ end of the coding sequence of various engineered dynein molecules. The authors report being able to label the dynein in specific locations using fluorescent dyes or quantum dots. HaloTag™ TMR Ligand was used to covalently label dynein to directly visualize dynein motor movement using total internal reflection fluorescence microscopy. HaloTag™ Biotin Ligand was used to label dynein with streptavidin quantum dots. (3504)
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The Ritz-Carlton, Wolfsburg is located near Volkswagen's worldwide headquarters and lies within the famed Autostadt.
Sit back and enjoy the cozy atmosphere in our Lobby Lounge with a cup of coffee or tea.
The Aqua embodies an award-winning dining experience, presented by Executive Chef Sven Everfeld.
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End your evening comfortably in the Newman's Bar while enjoying handcrafted cocktails.
The Ritz-Carlton, Wolfsburg is a Tier 1 property in The Ritz-Carlton Rewards.


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Scalable, Integrated Solutions for Elastic Caching Using IBM WebSphere eXtreme Scale
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Overview: This book discusses the scalability challenges and solutions facing today's dynamic business and IT environments. Topics discussed include existing scalability solutions, how WebSphere eXtreme Scale can be integrated into these solutions, and best practices for using WebSphere eXtreme Scale in different environments, including application data caching and database caching. Also included is an in-depth discussion of the WebSphere eXtreme Scale infrastructure, such as grid clients and servers, the grid catalog service, zone support, and scalability sizing considerations.


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Monday, August 18, 2014 (All day) to Friday, August 22, 2014 (All day)
The Panther Marching Band, the largest student organization on the UNI campus with more than 250 members, combines Panther spirit, pride, musicianship and more than 100 years of tradition. Students in the band will attend this week-long camp to begin rehearsals for the 2014 season. For more information, contact firstname.lastname@example.com.
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Best American Comics of 2012 | |
Written by Jen Vaughn | Filed under Renee French, Michael Kupperman, Joyce Farmer, Jordan Crane, Jonathan Bennett, Jim Woodring, Jessica Abel, Jaime Hernandez, Hotwire, Gary Panter, david sandlin, David Collier, Daily OCD, Chris Ware, Charles Burns, Best of 2012 | 2 Aug 2012 1:14 PM |
The book might not be out until October but you can peruse the table of contents of The Best American Comics 2012, edited by Fran oise Mouly, now!
Created by series editors, Jessica Abel and Matt Madden, this year's Best American Comics honors many Fantagraphics authors. Not only is there a Gary Panter cover but the inclusion of Jimbo, Joyce Farmer's Special Exits, Jim Woodring's Congress of the Animals, Jaime Hernandez's Love Bunglers from Love and Rockets, Michael Kupperman as well as Charles Burns, Blab's Nora Krug, Hotwire's David Sandlin, Jordan Crane, Jonathan Bennett, Renee French, David Collier and Chris Ware.


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Thu, Mar 12, 2015 at 1:48 PM
Watch Nicki Minaj's Pink Friday - Official...
Amazing commercial.! I love the fact that started out in black like Black Friday but when she cut herself on the rose its like she bleed pink. so like the her imprint is Pink Friday. Thats what I interperted as I watched the commercial. oh and her eyes were very you unique gorgeous, there awesome and different. Had me mesmerized byy them. Nicki looked exceptionally beautiful like always. Ugh.. it amazes me everything she does is new, refreshing, creative. I love it and I love heer soo much! <3 I very much so adore her!


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Treatment of Acute HIV Infection With Quad Fixed-dose Combination (FDC) Tablet (PHI04)
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This is a multicenter, single arm, 48-week open-label study of FDC ELV/COBI/FTC/TDF [Stribild] in acute HIV infection. Study sites will be members of the Duke-UNC Acute HIV Infection Study Consortium. Participants will be enrolled for 96 weeks. Clinical care and study drug (ELV/COBI/FTC/TDF) will be provided for the first 48 weeks. After week 48, clinical care but not study drug will be provided through week 96. A study participant suppressed at week 48 can continue on FDC ELV/COBI/FTC/TDF.
The primary hypothesis is that once daily fixed-dose combination elvitegravir (ELV), cobicistat (COBI), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF) will rapidly reduce viral replication to <50 copies RNA/ml in participants with acute HIV infection. The secondary hypotheses to be considered are 1) virologic response rates as measured by plasma HIV RNA levels will be non-inferior or superior to a historical group of participants from the PHI cohort treated with EFV/FTC/TDF, 2) compared to historical controls treated with EFV/FTC/TDF, plasma HIV RNA will decrease more rapidly in PHI participants treated with ELV/COBI/FTC/TDF, 3) compared to historical controls treated with EFV/FTC/TDF, immune activation as measured by the proportion CD4+ and CD8+ cells expressing HLA-DR and CD38+ will decrease more rapidly in PHI participants treated with ELV/COBI/FTC/TDF, 4)in a subset of participants samples will be obtained from compartments such as the gastrointestinal tract, and lymphoid tissues to assess changes over time in parameters such as HIV-1 RNA, immunologic responses to HIV, and tissue and anatomic reservoirs. We hypothesize that treatment with the ELV/COBI/FTC/TDF will demonstrate improved viral clearance in these compartments as compared to historical controls treated with EFV/FTC/TDF. 5) in a subset of participants who remain suppressed on therapy, resting CD4 cells with replication-competent HIV-1 (latent reservoir) will be quantitated and compared to similar measurements in PHI participants treated with EFV/FTC/TDF. In addition, we will compare these results to those measured in HIV-1 infected participants treated and 6) ELV/COBI/FTC/TDF will be well tolerated, and the proportion of participants who require treatment modification will be less than that observed in participants treated with EFV/FTC/TDF.
Condition | Intervention | Phase |
Drug: (FDC) ELV/COBI/FTC/TDF |
Phase 3 |
Study Type: | Interventional |
Study Design: | Endpoint Classification: Safety/Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | Treatment of Acute HIV Infection With the Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate, A Pilot Study of Response to Therapy and HIV Pathogenesis |
- viral load measurement of <200 copies/mL at week 24 [ Time Frame: 24 weeks ] [ Designated as safety issue: No ]
- virologic efficacy of the fixed dose combination (FDC) ELV/COBI/FTC/TDF given once daily to participants with acute HIV infection as determined by the proportion of treated participants with HIV-1 RNA to <50 copies/mL at week 48 [ Time Frame: 48 weeks ] [ Designated as safety issue: Yes ]
- rate of virologic decline in the first 24 weeks of treatment comparing FDC ELV/COBI/FTC/TDF to FDC EFV/FTC/TDF [ Time Frame: 24 weeks ] [ Designated as safety issue: No ]
Estimated Enrollment: | 30 |
Study Start Date: | September 2012 |
Estimated Study Completion Date: | September 2016 |
Estimated Primary Completion Date: | September 2015 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Quad FDC
FDC elvitegravir + cobicistat + tenofovir + emtricitabine STR once daily for 48 weeks
Drug: (FDC) ELV/COBI/FTC/TDF
Antiretroviral treatment
Other Name: STRIBILD
Detailed Description:
None desired
Ages Eligible for Study: | 18 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Acute HIV infection is defined as:
A positive 4th generation HIV Ag/Ab Combination Assay and HIV RNA (NAAT or viral load) and one of the following within 30 days of study entry:
- a negative HIV rapid test
- negative/indeterminate Western Blot
A negative or indeterminate HIV antibody, antigen, or nucleic acid amplification test (NAAT) and any one of the following within 30 days of study entry:
- A detectable HIV nucleic acid in blood confirmed by a second NAAT
- Positive p24 antigen
- A positive HIV antibody test according to standard criteria obtained within 45 days after an initial negative or indeterminate HIV antibody, antigen, or nucleic acid amplification.
Inclusion Criteria:
- Acute HIV Infection (as defined above) within 30 days of study entry.
- Age >18 years.
- ART-naive (<14 days of previous antiretroviral treatment. Exceptions are: Post-exposure prophylaxis (PEP) if participant was documented as HIV-negative at least 3 months after completion of PEP.
Lab values within 30 days prior to study entry:
- Absolute neutrophil count >500/mm3
- Hemoglobin > 8.5 g/dL for men and > 8.0 g/dL for women
- Platelet count >50,000/mm3
- AST (SGOT)> .2.5 x ULN
- ALT (SGPT)> .2.5 x ULN
- Total bilirubin <2.5 x ULN
- Calculated creatinine clearance (Cockcroft-Gault formula) > 70mL/min:
- For women of reproductive potential, a negative pregnancy test within 72 hours prior to initiating antiretroviral study medications. Reproductive potential is defined as females who have reached menarche and have not been post-menopausal for at least 24 consecutive months, or have not undergone surgical sterilization.
- Female study participants must use a reliable form of barrier contraception, such as a condom, even if they also use other methods of birth control. All participants must continue to use contraception for 12 weeks after stopping study medications. Acceptable methods of barrier contraception include: condoms (male or female), diaphragm, or cervical cap. These can be used alone or in tandem with hormonal or IUD method.
- Ability and willingness of participant to give written informed consent.
Exclusion Criteria:
- Women who are pregnant or breast-feeding.
- Women with a positive pregnancy test prior to study drug administration.
- Men who have sex with women, and women of reproductive potential unwilling or unable to use an acceptable, reliable barrier method of contraception for the entire study period and 12 weeks afterwards.
- Use of immunomodulators (e.g., interleukins, interferons, cyclosporine), HIV vaccine, systemic cytotoxic chemotherapy, or investigational therapy within 30 days of study entry (Prednisone 10 mg QD or less is permitted.
- Known allergy/sensitivity to study drugs
- Difficulty swallowing pills
- Inability to communicate effectively with study personnel
- Incarceration; prisoner recruitment and participation are not permitted
- Active drug or alcohol use that, in the opinion of the site investigator, would interfere with participation in the study
- Any active psychiatric illness that, in the opinion of the investigator, could confound the analysis of the neurological examination or neuropsychological test results
- Active brain infection (except for HIV-1), brain neoplasm, space-occupying brain lesion requiring acute or chronic therapy
- Serious illness requiring systemic treatment and/or hospitalization until patient either completes therapy or is clinically stable on therapy for at least 7 days prior to study entry
- Known cardiac conduction disease
- Prior treatment with any other experimental drug within 30 days of initiating study treatment
- Unable to discontinue any current medications that are excluded during study treatment
- Life expectancy less than twelve months
- Acute Viral Hepatitis, including, but not limited to, Hepatitis A, B, or C
- Chronic Hepatitis B Infection documented by a detectable serum Hepatitis B surface antigen (HBsAg) or plasma HBV DNA
- Calculated creatinine clearance (Cockcroft-Gault formula) <70mL/min
Please refer to this study by its ClinicalTrials.gov identifier: NCT01694420
Contact: Kara S McGee, PA-C, MSPH | 9196680242 | firstname.lastname@example.com |
United States, North Carolina | |
UNC at Chapel Hill | Recruiting |
Chapel Hill, North Carolina, United States, 27514 | |
Contact: JoAnn Kuruc, RN, MSN 919-966-8533 | |
Principal Investigator: Cynthia Gay, MD, MPH | |
Duke University Medical Center | Recruiting |
Durham, North Carolina, United States, 27705 | |
Contact: Kara S McGee 919-668-0242 firstname.lastname@example.com | |
Principal Investigator: Mehri McKellar, MD |
Principal Investigator: | Mehri McKellar, MD | Duke University |
No publications provided
Responsible Party: | Duke University |
ClinicalTrials.gov Identifier: | NCT01694420 History of Changes |
Other Study ID Numbers: | Pro00035447, IN-US-236-0124 |
Study First Received: | September 21, 2012 |
Last Updated: | February 16, 2015 |
Health Authority: | United States: Food and Drug Administration United States: Institutional Review Board |
Additional relevant MeSH terms:
HIV Infections Immune System Diseases Immunologic Deficiency Syndromes Lentivirus Infections RNA Virus Infections |
Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Virus Diseases |
ClinicalTrials.gov processed this record on May 05, 2015


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Get in the patriotic spirit with the 5th & Ocean women's Stars and Stripes T-shirt. This cotton crew neck is perfect for a day at the game or the beach. It features bold, colorful NFL® team graphics in a stars-and-stripes motif.
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Project: Cornwall Athletic Club
Project Details
Cornwall Athletic Club, based at Carn Brea in Cornwall are an athletic club with track and field, road running as well as cross country sections.
The club approached us as their existing web site was looking tired and was also costing too much money to maintain on the system that they had.
We developed their new web site with navigation and functionality in mind as many of the club's members use the site regularly to keep up with news, to check results and to check upcoming fixtures.
The site is updated daily and we built a content management system for the administrators so that they can get all the information and new pictures etc up as quickly as possible.
Services supplied include website design and development, content management system, search engine optimisation as well as web hosting and email services.
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Website Design | Web Hosting | Email Services | Content Management | SEO | Database Development
Website Address: www.cornwallac.org.uk


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Sunday, January 23, 2011
Sneak Peek | Fat Quarterly Issue #4
I am very excited to show a sneak peek of my latest quilt and pattern to be included in Fat Quarterly magazine:
I had a great time working with Kate Spain's new "Central Park" line for Moda, and with the issue's focus on working with solids, I was pleased to find 4 shades of shot cottons to coordinate with the prints.
Issue 4 will be released this coming Tuesday, January 25th to our subscribers, and available for single issue purchase on Thursday, January 27th. Learn more on our website at http://www.fatquarterly.com.
28 comments:
- Jennifer DuncanJanuary 23, 2011 at 11:52 AM
Ok, that is fantastic! I have this line for a project that at the last second I changed my mind on and used something else. It is sitting in the drawer calling my name and now I am inspired. I also really like that central block. Can't wait to see the pattern.
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Post Comments (Atom)


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Subscribe Now eEdition Login How to Advertise Customer Service Contact Us
dellrapidsinfo.com Weather Jobs Cars Homes Apartments Shopping Classifieds Calendar
Post 65 wins 4 of 6 with strong pitching, timely hitting
Dell Rapids Post 65 spanked Aurora 12-2 Monday, June 2 to pick up the win at Rickeman Field.Post 65 scored in four of seven innings but really sealed the victory in the sixth inning when they broke through with six runs.Riley Schmidt picked up the win for Dell Rapids. He threw six innings and struck out seven batters. He gave up three hits and two earned runs.Schmidt helped his cause with a 3 for 4 day at the plate. Cody Nielsen hit a double and a two-run homerun to lead Post 65, and Ryan Geraets had a pair of singles in two at-bats.Post 65 3, Humboldt 0Nielsen dominated Humboldt with a shutout 3-0 win Wednesday, June 9 in Humboldt.Nielsen picked up his first win of the year with a 10-strikeout performance in five innings of work. The triple-sport athlete gave up one hit and walked four batters. Post 65 earned just five hits in the seven-inning contest. But when men were on base, they took advantageSchmidt, Nielsen, Nathan Klein, Austin Kubly and Beau Carpenter all had one hit each. Mitch Roemen picked up the two-inning save for Dell Rapids by retiring all six batters he faced."We are playing some great baseball right now," said Jordan Solberg, Post 65 head coach. "We have a very talented and deep team. It is great to see players coming off the bench and doing an excellent job." Post 65 17, Flandreau 6Flandreau fell victim to Post 65 Monday, June 9 in a 17-6 beating at the Fliers' park.Roemen picked up the win with a complete game performance in which he struck out 10 Flandreau batters. Adam Karst had a double and scored four runs to lead Dell Rapids offensively. Schmidt and Carpenter each had three hits.Luverne 14, Post 65 8Dell Rapids' hot streak was dashed Monday, June 9 when Luverne scored six runs in extra innings to down Post 65 14-8 in Flandreau. Joe Muston led the Dell Rapids offense with two hits and two runs batted in.Post 65 7, Scotland 2Nielsen went 2 for 2 and scored four times to lead Dell Rapids past Scotland 7-2 Saturday in Scotland.Muston went 3 for 4 and scored twice for Post 65, and Klein had three hits.Roemen picked up the win by throwing another complete game, striking out nine and giving up four hits.Lennox 4, Post 65 0Dell Rapids bats went cold as Post 65 left 11 runners stranded and fell 4-0 to Lennox Saturday in Scotland.Post 65 got two hits from both Zachary Schroeder and Klein. Nielsen picked up the loss despite striking out 10 batters in four innings."We were short handed on Saturday but played some good baseball," Solberg said.
Argus Leader
Dell Rapids Public School
Dell Rapids St. Mary's Catholic School
Dell Rapids Chamber of Commerce
City of Dell Rapids


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click the link, you can see ascaris talk about my dick and how big it is
click the link, you can see ascaris talk about my dick and how big it is
ascaris on my dick pics
hahahahahahafold it in the shape of an a for ascaris so ill know its yours
you know, i was supposed to play league and go to bed early tonight. now i've spent the last two hours on cosmo.
lord, i demand answers. speak for verslie as well.
How did I manage to post that much?
Wish I could see my postcount on cosmo.
But my account was deleteeeed.
pichubro i saw your account last night, it was hyperferret and it had a signature with cosmos banner in it.
Why wasn't my account showing up under the member's list? xP
the internet works its magic when you need it to, not when you want it to
Yeah, like when it locked me out of my account forever~
I was not worthy
I was thinking about Cosmo a few nights ago. Very hard to believe it started three years ago.
you were basically the only one who ever talked about aorio hoshi or old pokecosmo and members nobody knew about. when you made that post saying i was involved in a huge circlejerk, nothing i'd posted up til that point resembled anything reminiscent of a circlejerk. you basically agreed with verslie because he was on your side even though his posts in that thread made zero sense lol.
Two separate things. When I said you were involved in a huge circlejerk I was referring to Cosmo as a whole. Cosmo was a massive circlejerk, no one can deny this. It was a bunch of teenagers who endorsed and wrote a timeline which detailed their online adventures for fuck's sake.
I think. Otherwise I have no idea what I was saying.
I think PD is the only forum with minimal staff involvement that has survived the 10 year mark (or almost 10 years). All we mods really do is delete spambots these days.
Of course, there is the website that helps support it but it's not like Wei returns the favor by advertising the forum much.
nah you're completely wrong.
stupidest rekhyt post ever. no sense whatsoever. this post was like 3 days after the forum was made and i had less than 50 posts haha.then you have justin and teku and jericho and celery and retro bug who make the place look like a giant circlejerk. the only members that make this place look even remotely okay to someone who's never seen us before are vendak and
i can't even think of anybody else
those posts were mutual masturbation between you and vendak. us posting in the spam forum was not a circlejerk lol
I have found a few other 'active' forums with dead mainsites, however the administration is usually much more active.


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Wilson made good on 23-of-34 attempts and Bubba Poole provided 186 yards of total offense for the Utes (4-2, 1-2 Pac-12), who rebounded from a loss to UCLA last week.
Poole rambled for 111 yards on 22 carries while also catching seven passes for 75 yards.
The Cardinal (5-1, 3-1) had its 13-game winning streak snapped as Kevin Hogan was held to 246 yards and a touchdown on 15-of-27 efficiency.
Tyler Gaffney led Stanford's ground game with 108 rushing yards and a score on 16 carries.


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5 Albums You Must Hear This January
Add Justin Townes Earle and these others to your playlists ASAP.
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Get up to date on the most excellent releases of the year thus far.
Weezer, Prince and more Thurston Moore.
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Young righties Cobb, Hutchison get nod at the Trop
Rays, Blue Jays continue season-opening four-game series
ST. PETERSBURG, Fla. -- The Blue Jays and Rays will send a pair of promising right-handers to the mound when the two teams square off Tuesday night at Tropicana Field.
Tampa Bay will go with Alex Cobb, while the Blue Jays will counter with Drew Hutchison. If either team hopes to contend this year, it likely will be because of strong years from its young arms.
Cobb gets the honor of following left-hander David Price in the rotation after a year in which he posted a 2.76 ERA in 22 starts.
"I think his confidence is even greater right now," Rays manager Joe Maddon said. "You can't say his stuff's any better. Maybe just the utilization of those pitches might be a little more refined. I think he's done a better job out of the stretch.
"So I think that's something we've talked about that he's gotten better with. But primarily he has a real confidence level. This guy is Opening Day starter-caliber. ... He's very worthy of pitching on anybody's Opening Day. And he knows that."
Hutchison became one of the Blue Jays' biggest storylines during Spring Training as he led the club with 19 strikeouts in 15 innings. He arguably had the best spring of any Toronto pitcher despite missing all of last season following Tommy John surgery.
There were no lingering effects of that injury this spring, and after a quiet offseason, the Blue Jays are clearly relying on Hutchison to fill a big hole in their rotation.
"We like him, he has a chance to become a really good one. Ever since he had the Tommy John, he's throwing better than he was," manager John Gibbons said. "He's a pitcher ... he's kind of an effortless-type guy. I think he's going to have a big, big year for us."
Blue Jays: Reyes on DL with tight hamstring
Toronto has only played one game this season and is already reeling because of injuries. The club lost closer Casey Janssen just one day before the start of the year and during the first inning of Opening Day Jose Reyes also went down with an injury.
Reyes suffered a strained left hamstring following his first at-bat of the year and was placed on the 15-day disabled list. It's the same injury he dealt with during the final week of Spring Training and cost him several exhibition games.
"Hopefully it doesn't get any worse, if it gets any worse it's going to be disappointing not just for me but for the whole team," Reyes said just before the DL news became official.
"I worked so hard this offseason just to get ready for Spring Training, play for a full year, and now I have to deal with this thing, it's no fun at all. I want to be on the field but it's one of those things, injuries happen, it's part of the game and I have to deal with it."
Rays: DeJesus questionable with foot injury
Left fielder David DeJesus had to leave Monday's 9-2 victory over the Blue Jays in the eighth inning after getting hit on the right foot in his fourth at-bat.
Blue Jays right-hander Jeremy Jeffress hit DeJesus with one out. After DeJesus took his base, he was lifted for pinch-runner Brandon Guyer. X-rays were taken and came back negative. When asked if he would play Tuesday, DeJesus replied: "[I'll] see how it feels, you know. Just go like that."
Worth noting
• The Blue Jays haven't won a road series vs the Rays since April 6-8, 2007. The stretch of 19 consecutive non-winning series at Tropicana Field is the longest such streak since the Rays had 25 consecutive non-winning series at Fenway Park from 2000-08.
• With Monday's victory, Tampa Bay improved to 50-17 since 2008 when playing in front of home crowds of at least 30,000 during the regular season.
• Outfielder Wil Myers tied his career high with three hits during his first season opener. The last Rays players to record three hits on Opening Day were Evan Longoria and Carlos Pena in 2012 against the Yankees.
Gregor Chisholm is a reporter for MLB.com. Read his blog, North of the Border, and follow him on Twitter @gregorMLB. This story was not subject to the approval of Major League Baseball or its clubs.


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An amazing and wonderful girl. She is crazy and the funniest person you will ever meet. She likes the color orange, purple bunnies, and giraffes. She can do cute impressions of little kids and all the guys love her. She is a beauty beyond compair and she loves her friends more than anything else. She is chill and smiles a lot
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Evgenia Kanaeva, Longines Ambassador of Elegance and Queen of the World Championships
Since 2009, the Russian Evgenia Kanaeva is part of the Longines family. That year, at the Rhythmic Gymnastics World Championships, she had won every single gold medal of the competition, including Individual All-Around final, the four apparatus finals, and the teams ranking. It seems it wasn't enough gold for her as she took all the 6 titles again in Montpellier this year. At only 21 years old, she confirms that she is the absolute champion having already one Olympic gold medal and seventeen world champion titles.
The Longines family congratulates her for her outstanding performances.


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(Preview) Tiffany: RWB HK Porsche 911 Carrera 964
Written by Jordan Lenssen | Photography by Linus LamIn the heart of Chiba, Japan lies a shop completely unbeknownst…
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XS Power introduces the new D3400R right terminal, group 34R style battery.…
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Konig Calendar Model: May 2015 - Amy Fay
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AutoCon 2015: Pomona, CA
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Photos by Paul Nguyen Photography AutoCon was hosted at the Fairplex in Pomona, CA on April 25, 2015. Stay tuned for full coverage in an upcoming print issue of PASMAG! For more AutoCon event info, visit www.autoconevents.com. Stay tuned for…
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Photo by Shane Hunter Gallery The annual NissanFest was hosted at Evergreen Speedway in Monroe, Washington on April 26th by Northwest Nissans (NWN) and NWMOTIV.com. Modified and OE Nissans of all years and models from the Pacific Northwest (Oregon and…
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Formula Drift Round 1 2015: Long Beach, CA
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Pkgsrc in PC-BSD®
Available to PC-BSD® is its own PBI collection, FreeBSD ports, and FreeBSD packages. However, it is also possible to use the NetBSD pkgsrc system to build software. This is not (yet) a pre-configured feature, which means there are some special instructions to follow for this functionality to be enabled. This is not an official feature. This section will describe how to configure and use NetBSD pkgsrc from PC-BSD®.
NOTE: Although these instructions seem complete and look polished, there may still be ommissions or inaccuracies, so be wary.
Setting things up
- Obtain the NetBSD pkgsrc tree by the following commands:
- # ftp ftp://ftp.NetBSD.org/pub/pkgsrc/current/pkgsrc.tar.gz
- # tar -xzf pkgsrc.tar.gz -C /usr
- # ftp ftp://ftp.NetBSD.org/pub/pkgsrc/current/pkgsrc.tar.gz
- Bootstrap pkgsrc. FreeBSD stores its ports pkg database in /var/db/pkg/. It is therefore recommended to use /var/db/pkgsrc/ with the --pkgdbdir flag as below:
- # cd /usr/pkgsrc/bootstrap/
# ./bootstrap --pkgdbdir /var/db/pkgsrc
- # cd /usr/pkgsrc/bootstrap/
- The NetBSD pkg tools and FreeBSD pkg tools have identical names. It is recommended to change the name of the NetBSD set to match 'bmake' by prepending a 'b' to each, as follows:
- # cd /usr/pkg/sbin/
# mv pkg_add bpkg_add
# mv pkg_create bpkg_create - # mv pkg_delete bpkg_delete
# mv pkg_info bpkg_info
- # cd /usr/pkg/sbin/
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- # cd /usr/sbin/
# mv pkg_add pkg_add.orig
- # mv pkg_create pkg_create.orig
# mv pkg_delete pkg_delete.orig
# mv pkg_info pkg_info.orig
- # cd /usr/sbin/
- Add the location of bmake (/usr/pkg/bin) and NetBSD pkg tools (/usr/pkg/sbin) to the user's search path variable. Edit the file .cshrc in the user's home directory to modify the following line:
- set path = (/sbin /bin /usr/sbin /usr/bin /usr/games /usr/local/sbin /usr/local/bin /usr/pkg/sbin /usr/pkg/bin $HOME/bin)
- set path = (/sbin /bin /usr/sbin /usr/bin /usr/games /usr/local/sbin /usr/local/bin /usr/pkg/sbin /usr/pkg/bin $HOME/bin)
- Add the PKG_PATH definition for the latest collection of pkgsrc packages (5.1_2011Q4) to the user's .cshrc file with the following line:
- setenv PKG_PATH ftp://ftp.netbsd.org/pub/pkgsrc/packages/NetBSD/`uname -m`/5.1_2011Q4/All/
- setenv PKG_PATH ftp://ftp.netbsd.org/pub/pkgsrc/packages/NetBSD/`uname -m`/5.1_2011Q4/All/
- Obtain the vulnerabilities file:
- # /usr/pkg/sbin/pkg_admin -K fetch-pkg-vulnerabilities
- This prevents the non-fatal error below:
- WARNING: No /var/db/pkg/pkg-vulnerabilities file found.
- WARNING: To fix run: `/usr/sbin/pkg_admin -K /var/db/pkg fetch-pkg-vulnerabilities'.
- WARNING: No /var/db/pkg/pkg-vulnerabilities file found.
- # /usr/pkg/sbin/pkg_admin -K fetch-pkg-vulnerabilities
- The vulnerabilities of some ports (ie Firefox) may prevent them from being built. An example mk.conf file will be placed in /etc/mk.conf.example file when you use the bootstrap script. Adjust /usr/pkg/etc/mk.conf to allow vulnerable programs to be built by adding the following line:
Keeping pkgsrc up to date
- The process for using tar files is very much the same as when obtaining them originally, except that the old tree must be erased first
- # rm -rf /usr/pkgsrc/
- # ftp ftp://ftp.NetBSD.org/pub/pkgsrc/current/pkgsrc.tar.gz
- # tar -xzf pkgsrc.tar.gz -C /usr
- # rm -rf /usr/pkgsrc/
- Next bootstrap pkgsrc again
- # cd /usr/pkgsrc/bootstrap/
- # ./bootstrap --pkgdbdir /var/db/pkgsrc
- # cd /usr/pkgsrc/bootstrap/
- Update the bootstrap-mk-files
- # cd /usr/pkgsrc/pkgtools/bootstrap-mk-files/
- # /usr/pkgsrc/bootstrap/work/bin/bmake update
- And if that does not work (such as on a standard NetBSD install) try:
- # /usr/pkgsrc/bootstrap/work/bin/bmake replace
- # /usr/pkgsrc/bootstrap/work/bin/bmake update
- # /usr/pkgsrc/bootstrap/work/bin/bmake replace
===> Installing for bootstrap-mk-files-20111205 ERROR: bootstrap-mk-files-20111106 is already installed - perhaps an older version? ERROR: If so, you may use either of: ERROR: - "pkg_delete bootstrap-mk-files-20111106" and "/usr/pkgsrc/bootstrap/work/bin/bmake reinstall" to upgrade properly ERROR: ERROR: - "/usr/pkgsrc/bootstrap/work/bin/bmake update" to rebuild the package and all of its dependencies ERROR: ERROR: - "/usr/pkgsrc/bootstrap/work/bin/bmake replace" to replace only the package without re-linking dependencies, ERROR: risking various problems.
Using pkgsrc to build
Much like using the FreeBSD ports system, building with the NetBSD pkgsrc system is a rather simple matter of going to the location of the application within the pkgsrc tree, and then using bmake, for example:
- % su -m
- # unsetenv PKG_PATH
- # cd /usr/pkgsrc/www/firefox/
- # bmake install clean
However, if there may be options that would modify what is built, how it is installed, or the features enabled. The additional steps for options adjustment is done prior to invoking bmake install clean. Discover whether there are options:
Adding a NetBSD pkg
- % su -m
- # bpkg_add firefox
The above probably should simply work, or the NetBSD documentation would not mention renaming the FreeBSD pkg tools. However, for the moment, testing this throws the following type of error:
Xterm | ||||
pkg_add: Warning: package `firefox-3.6.16' was built for a platform: |


text:
May 4, 2015
Americus-Sumter star Jayme Gilbert, right, drives past Dougherty's Jasmine Lavant on Tuesday during their huge Region 1-AAA showdown at the Civic Center. Americus won, 59-43.
One of the largest basketball tournaments is coming to Dothan.
Many Dothan officials and business owners think this tournament will be nothing but net.
The South Regional Basketball Tournament will be in Dothan starting this Tuesday through Saturday.
It's a high school tournament featuring several male a female high school teams from across the state.
"We'll have 48 teams, that'll be participating, so we'll have a lot of people coming to Dothan they'll be coming from mobile, to Dothan, up to around troy and all points in between those areas," says Larry Patrick, Assistant Director of Dothan Leisure Services Department.
With so many teams in the five day tournament it will add a few points to Dothan's financial scoreboard.
"This tournament with have a tremendous impact on the city of Dothan financially, we'll have a lot of people coming to Dothan, spending their money in our restaurants, or buying gasoline and staying in our hotels," says Larry Patrick, Assistant Director of Dothan Leisure Services Department.
And that is music to the ears of downtown restaurant owner Bulut Kartar
"As long as we have that crowd in downtown, so it's going to be beneficial for businesses in downtown," says restaurant owner Bulut Katart.
The tournament is an effort that has been warming the bench for quite some time now.
"It's something that we've wanted to see happen here for a long time, it brings a lot of teams and a lot of people to our community," says Jansen Tidmore, Executive Director, DDRA
It's a tournament that is sure to be a slam dunk for the Dothan economy and a fast break for the entire family.
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Friends of the Library to host Scotty Kirkland Jan. 25
01/14/2015 - 11:30am
MOBILE, Ala. – The Friends of the Spring Hill College Library are hosting an afternoon with the History Museum of Mobile's Scotty E....
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SHC Awarded National Chemistry Grant
01/09/2015 - 11:45am
The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy has announced that Spring Hill College is among its 13...
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SHC Professor's OpEd Published in Times-Picayune
01/07/2015 - 8:45am
"Two hundred years ago an unlikely hero emerged from the Battle of New Orleans: a French-born pirate, smuggler and privateer named Jean...
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Baugh Named to Mobile Bay's "40 Under Forty"
01/06/2015 - 1:00pm
Dr. Matthew Baugh, S.J., assistant professor of politics and law at Spring Hill College, has been named to Mobile Bay's 2014 class of "40...
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SHC Women Win SIAC Season Opener
01/05/2015 - 11:00am
The Spring Hill College (SHC) women's basketball team opened its debut season in the Southern Intercollegiate Athletic Conference (SIAC)...
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Ryan Sanchez '15 ~ Learning, Faith, Justice, & Service
01/05/2015 - 9:45am
As Spring Hill College senior Ryan Sanchez can attest, the journey through a pre-med program is not an easy one. It's a rigorous four years...
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SHC's Brohanon Signs to Play Professional Rugby
12/23/2014 - 9:15am
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Hannah Gassie '15 ~ Science, Scholarship, & Surgery
12/19/2014 - 7:30am
An invitation for Spring Hill College's Science Day first piqued Hannah Gassie's interest in pursuing her undergraduate degree in Mobile,...
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Christmas Eve Mass 2014
12/17/2014 - 2:00pm
Join SHC alumni, faculty, staff, and friends for Christmas
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SHC Student-Athletes Help Families in Need
12/12/2014 - 10:00am
The Spring Hill College (SHC) Student Athlete Advisory Committee (SAAC) is offering a helping hand to families in need this holiday season...
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Matthew Keller '15 ~ A Leader in Service to Others
12/11/2014 - 2:00pm
There is no doubt that senior Matthew Keller '15 embodies the Spring Hill College mission of "Forming leaders engaged in learning, faith,...
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Spring Hill College inducts new members of Alpha Sigma Nu
12/10/2014 - 1:45pm
MOBILE, Ala. – Twenty-two students at Spring Hill College were recently inducted into Alpha Sigma Nu, the premier honor society for Jesuit...
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FOX10, WPMI, & AL.com Cover SGA Event
12/09/2014 - 9:00am
SHC students took a break from studying for finals Monday to snuggle with furry friends in need of good homes! The SGA hosted a coffee...
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SHC Students Head to Medical School
12/04/2014 - 11:15am
Three Spring Hill College seniors are headed to St. Louis University (SLU) Medical School in the fall of 2015, with two more SHC students...
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Dr. Rowan Spearheads Literacy Project
12/04/2014 - 11:00am
Dr. Leona Onderdonk Rowan, Spring Hill College professor and teacher certification officer, was recently awarded $2,500 from the Bedsole...
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SHC Awarded NetVUE Grant
11/24/2014 - 2:30pm
Spring Hill College has been awarded $50,000 by the Network for Vocation in Undergraduate Education (NetVUE), a nationwide network of...
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Tony Nalovic '02 ~ Sea Turtles, Sharks, & SHC
11/17/2014 - 9:00am
Tony Nalovic's passion for marine biology has taken him all over the world—across the Caribbean Sea and Atlantic Ocean, to Virginia,...
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Coast Guard Honors Theresa McGonagle Crider '04
11/13/2014 - 4:15pm
Commanding Officer Tom MacDonald of the Mobile, Ala. Coast Guard Aviation Training Center (ATC) recognized Theresa McGonagle Crider '84 '04...
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Embracing Real Beauty
11/12/2014 - 2:15pm
Dove Real Beauty Spokesperson Stacy Nadeau will speak at Spring Hill College Thursday, November 13 on Embracing Real Beauty....
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Artist Talk with Vincent Lawson
11/10/2014 - 10:30am
Vincent Lawson will speak to Spring Hill College November 11 about the process of creating his art and the influence for his collections....
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