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2009 Ford F-100 Supernationals - It's Tennessee Time!
Written by on November 1, 2009 31st Annual F-100 SupernationalsEvery May for the last 31 years there has been quite the all-Ford truck show held in Tennessee. People come from all over the country for it, since there is really no other F-100 show like it in the United States. Since 2004, the show has been held in the spacious Chilhowee Park in Knoxville, and upwards of 1,000 Ford trucks fill the grounds, despite the predictable but intermittent spring showers. This year was also the changing of the guards, as it were. Pat Ford decided at the close of the '08 F-100 Supernationals to relinquish the show that he started three decades ago and slow down and enjoy life with his wife. Another show promoter from the South, Charlie Cobble of Autoshows Motorsport Events, bought the F-100 Supernationals and with a little help from Pat, took the reins.
The '09 F-100 Supernationals also saw a change in what was let into the show; it was opened to all Fords instead of just trucks. This isn't that big of a change because there were always special Ford clubs or groups invited to the show to add a bit of variety. There are classes for just about everything now, from '48 and earlier all the way to '09 Mustangs, which may help or hinder the show-only time will tell.
One thing that hasn't changed is that the F-100 Truck Of The Year award is still only open to '53-56 F-100s. We know things have been done a certain way for a long time, and it's not our show, but given what people are doing with "other" F-100s these days it seems there should be some thought to opening the big trophy up to any truck with an F-100 on the pink slip. We remember when it was even said on stage at the awards a few years back that Gary Coe's '57 "F-157" should have won, but couldn't. This year was no exception with Kirk Johnson's Roseville Rod and Custom-built '68 F-100.
The '09 show was still great and it was good to see many friends and feature trucks from past years as well as meeting new faces and avid readers. We appreciate all the kind words and support-keep building trucks and we'll keep putting them in the magazine! For information on the '10 F-100 Supernationals and all-Ford show, as well as the '10 Black Oval giveaway truck, visit www.f100supernationals.com, or call 423-623-4644.


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By JIM HIGHTOWER Otherwords
"In the wealthiest nation on Earth," President Barack Obama declared in his State of the Union speech, "no one who works full-time should have to live in poverty."
Right! Not only does his call to raise America's minimum wage put some real pop in populism, but it could finally start putting some ethics back in our country's much-celebrated, (but rarely honored) "work ethic."
Kudos to Obama for putting good economics and good morals together - and for putting this long overdue increase on the front burner.
But then came the number: $9 an hour. Excuse me, Mr. President, but that means a person who "works full-time" would nonetheless "have to live in poverty." Yes, nine bucks is a buck-seventy-five better than the current pay, but it's still a poverty wage. It doesn't even elevate the buying power of our wage floor back to where it was in 1968.
Minimum Wage, Maximum Drama, an OtherWords cartoon by Khalil Bendib
This isn't merely about extending a badly needed helping hand to people struggling to work their way out of poverty, but about letting them give a jolt of new energy to our economy, which it desperately needs.
Ironically, the rich save and the poor spend. While super-rich corporations are hoarding trillions of dollars in offshore accounts and refusing to invest in America, minimum-wage workers invest every extra dollar they get in America - spending it right where they live on clothing, food, health care, and other basic needs.
A 2011 Federal Reserve study found that a one-dollar hike in the minimum wage produces an additional $2,800 a year in spending by each of those households. This is no time to shortchange these workers.
Yes, I know that GOP lawmakers and corporate lobbyists oppose even a $9 wage. But a poll last June found that seven out of 10 Americans (including a majority of Republicans), support raising the wage above $10 an hour. This is a time, Mr. President, to think big and listen to the grassroots.
OtherWords columnist Jim Hightower is a radio commentator, writer, and public speaker. He's also editor of the populist newsletter, The Hightower Lowdown.

subset: commoncrawl


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1. Voodoo
2. Arc Angels
3. Carnival
Emeka Okafor - Joe Smith - Carmelo Anthony - Manu Ginobili - Jason Williams
Al Jefferson - James Posey - Aaron McKie - Shaun Livingston
Was reading the paper today (while I can), and saw an article about the retirement of a local institution...and thought the New Orleans Nobles sounds pretty good. Thoughts?
Actually, Royals is a very fitting name for a New Orleans franchise. Louisiana and New Orleans, from it's founding to the Louisiana Purchase, were under the control by France, Spain, then again France. King Louis XIV (for which Louisiana is named), Regent Duc Phillipe of Orleans, King Louis XV of France, then by King Charles III and King Charles IV of Spain all ruled over Louisiana and New Orleans until the Louisiana Purchase. New Orleans, of course, is named after the Royal Duke of Orleans. The Fleur de lis, obviously the symbol of New Orleans and Louisiana, appears on the Royal Coat of Arms of both France and Spain.
More modernly speaking, Mardi Gras is centered around the concept of "Royalty." King Rex, the King of Carnival. The King and Queen of Zulu, the Queen of Muses, etc. Every Krewe has a Royal Court, made up of Maids and Dukes. The Colors of Mardi Gras, Purple (Justice), Green (Faith) and Gold (Power) not only carry Regal significance, they were also chosen as the official colors by the Grand Duke Alexis Alexandrovitch Romanoff of Russia on a visit to Carnival in 1872. The formal end of Mardi Gras arrives with "the Meeting of the Courts", a the ceremony at which Rex and His Royal Consort, the King and Queen of Carnival, meet with Comus and his Queen at the ball of the Mistick Krewe of Comus. We can't forget about the King Cake and it's significance to Mardi Gras and New Orleans as well.
So as you can see, the name "Royals" has a much deeper and more diversified significance to New Orleans than even the good nicknames such as Blues, Crescents, Pelicans and especially more than the WNBA gimmicks such as Krewe, Voodoo, and Bounce.
If there was a way to pry it from Sacremento, I would love to have that name. It's a name with signifiance and class. A big time free agent could say, "I want to be a Royal." Sounds better than "I want to be a Bounce, a Voodoo, or a Krewe." Screams WNBA.
Also, there ain't nothin Royal about Kansas City, Sacremento, or Anaheim. Just sayin.
I never said a name would decide what free agents we could get. I'm just saying it sounds dumb. Say it to yourself.
"I'm excited to be a New Orleans Bounce." huh???
"Tonight on ESPN, Derrick Rose and the Chicago Bulls Take on Anthony Davis and the New Orleans Voodoo!"
"Sullinger is killing the Krewe tonight not being able to hedge on that pick and roll!"
You constantly seem to forget that the Sacramento Kings own the Royals name.
The Kansas City Royals name was from the American Royal livestock and annual rodeo held in KC since 1899. It's also a tribute to the Kansas City Monarchs of the Negro Leagues. Obviously you rather talk out of your butt instead of just using the facts. It's a constant theme of your posts.
Please Dave and Tom, let us change the name tomorrow. Just so these threads can close. Please.
I know I could just stop reading or posting, but that's much harder than Dave saying Tom can change the name, and Tom just changing the name.
He could call it the New Orleans Boogies (can't believe I didn't use this before), and I would be happy. Voodoo, Dukes, Krewe, Cheese, Bridges, wtf, just change it. Please for the love of God, make it happen.
"we might make dollars, but we don't necessarily make sense"
"always be sincere....whether you mean it or not"
Ha! Setting up wordplay... comedy... pure comedy...
"Aime la vérité, mais pardonne à l'erreur." - François-Marie Arouet (Voltaire)
BIG DUB you can trust me as well...i mean who the hell am i gonna tell my imaginary friends
Good point. We are like buzzing of flies to heeeem....
Divine Comedy!
June 16: New Orleans Guardians
June 15: Big Easy Big Shots
June 14: New Orleans Frenchmen
June 13: New Orleans Marquis
June 12: Louisiana Boucherie
June 11: New Orleans Jacksons (Jax)
June 10: New Orleans Cathedrals
June 9: New Orleans Bon Temps
June 8: New Orleans Resilience
June 7: New Orleans Defenders
June 6: New Orleans Sportsmen
June 5: New Orleans Governors
June 4: New Orleans Trumpters
June 3: New Orleans Maskers
June 2: New Orleans Misfits
June 1: New Orleans Desire
There are a couple I think are good on this list so far, but I think Guardians may have some legs, at least at this hour. It's got an Angel thing, a Spirit (as in a commonly held feeling) thing, a basketball thing, logo potential.
New Orleans Tomato Trucks
New Orleans Street Vendors
New Orleans Urchins
New Orleans Fightin' Seminarians
New Orleans Medians
New Orleans Pralines
New Orleans Sportsmen
New Orleans Fishermen
New Orleans Fish
New Orleans Plantations
New Orleans Weirdos (play the Charlatans song)
I don't like when people try to come up with deep reasons why they don't like a name. Just say you don't like the name, that it's your opinion, and move on with it. I don't like the name Krewe. I don't have a deep reason why. I just don't. I like Voodoo, Pelicans, Knights, Dukes, and most other names. I don't have a deep reason why. I just do. Coming up with reasons for having an opinion on a name that devolve into ridiculous debates is just...well...ridiculous.
a couple of really good P efforts by Panic, but now for the P that will have all of us feeling so much better after a few beers....the New Orleans Ponchartrains!
hey Jason! after reviewing some of the "logic" I am hearing here lately about nicknames, I think I might be on to something.....I am sure that most of us recognize that the vast majority of Hindu's consider the bovine to be extremely, extremely sacred (certainly to the chagrin of WhoDatChristian)....and taking into account that there is a rather common term, in this country, that is usually used in reference to a young male (and depending on context etc., many find very, very offensive in respect to their heritage)....I just don't see any way a person, of any Faith, could even possibly consider naming a professional sports franchise the Cowboys!
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text: Homeopathic Materia Medica by FarringtonCUCURBITACEAE( )Today we begin our study of the CUCURBITACEAE. This order gives us some six or eight drugs and also some edible substances. Among the latter, are the water-melon, canteloupe, and cucumber. The seeds of some of these, have diuretic properties, and those of the water-melon, have been used as a cure for worms.Of the medicinal substances obtained from this order we may say that they all act prominently on the alimentary tract. They seem to have in common, a cathartic action. They probably act paralyzingly on the vaso-motor nerves of the abdomen. They produce griping pains, gushing watery diarrhoea. This last symptom is most prominent under ELATERIUM. Let us now enumerate these medicines. Fifth on the list is the MOMORDICA BALSAMUM, of this we have but one characteristic symptom and that is accumulation of flatus in the splenic flexure of the colon. It is a very convenient thing to know this. For instance, if during the course of a more or less chronic disease, this one symptom becomes very annoying and you do not want to destroy the action of the drug you are giving, you simply interpolate a dose of MOMORDICA, which removes the symptom and enables you to go on with the treatment as before. ELATERIUM, another member of the order, has been used principally in our school of medicine, in a peculiar form of diarrhoea. Like all the Cucurbitacese, it acts powerfully on the alimentary tract, producing a sudden and enormous effusion of serum into the bowels. Thus it causes a watery diarrhoea, the stools flowing out very profusely. The characteristic symptom of the drug and the one which will lead you to its selection in cholera infantum, is watery stools of an olive green color coming out with a gush. Thus you see it is comparable with CROTON TIGLIUM, PODOPHYLLUM and VERATRUM, ALBUM and. remedies of that type. It is readily distinguished from CROTON TIGLIUM, which is adapted to a profuse yellow watery stool, which is provoked every time the patient eats or drinks. PODOPHYLLUM has as you all know, the morning aggravation to distinguish it. The remaining medicines belonging to the Cucurbitaceae are the CITRULLUS or water-melon; the CUCURBITA or squash, the seeds of which as well as those of the pumpkin have been used for taenia; the COLOCYNTH and the BRYONIA ALBA ; the last two named being drugs of great importance; we will therefore proceed to their consideration, IN EXTENSO.


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Media Contact: Hannah Buchanan Public Affairs Specialist News and Information The University of Texas at Tyler 903.565.5769
Schulenburg Resident Named to UT Tyler Fall 2008 President's Honor Roll
Beth Launius of Schulenburg is one of 293 students named to The University of Texas at Tyler President's Honor Roll for the 2008 fall semester.
To be named to the President's Honor Roll at UT Tyler, a student must have completed, in one semester, 12 or more semester credit hours with grades of "A" in all courses that carry grade points.
One of the 15 campuses of the UT System, UT Tyler offers excellence in teaching, research, artistic performance and community service. Nearly 90 undergraduate and graduate degrees are available at UT Tyler, which has an enrollment of more than 6,000 high-ability students at its campuses in Tyler, Longview and Palestine.
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I do not understand why they will not just make the source code available. Is this an open source project or not?
Phoronix: The ZFS Linux Module Goes Into Closed Beta
We reported last month that a native ZFS module was coming to Linux and would be released in mid-September. Rather than using ZFS-FUSE that runs the Sun/Oracle ZFS file-system under the FUSE module so that it lives outside the Linux kernel (and runs rather slowly as our benchmarks show), this new ZFS module is native to Linux and open-source but due to the CDDL license it's being distributed as a module and will not be included in the mainline Linux kernel. This module has now entered a closed beta testing process...
I do not understand why they will not just make the source code available. Is this an open source project or not?
Michael: Your benchmarks are flawed. zfs-fuse runs at virtually platter speed and can keep up with the best of them. There are certain tweaks required in order to obtain this performance though. Anyone serious in using ZFS would best be advised to understand how to work it.
As for this closed source zfs blob module... the hostility of the developers clearly proves to me that they lack the discipline required to write a filesystem driver that anyone could actually depend on. Here's one ZFS user who has no interest in risking anything to them.
Of course you are in. It's free publicity for them.Originally Posted by phoronix
I understand that there are people and businesses out there who are trying to find ways to monetize on open source code. Code that they did not create and do not hold the copyrights of. Incorporating such code in your own product is one way of doing it, but this has to be done by respecting the license of the code you are using. With all this closed beta and restricting access and all I get the impression that they are not very willing to release the source code. Question is by not doing so are they complying with the CDDL?
Originally Posted by CDDL
If they release the source code to any of their beta testers, then by the CDDL, the beta testers are explicitly allowed to distribute the code. The article Michael wrote does not indicate whether what you get with the closed beta is the code, or a module. Can you please clarify that much, Michael? If they give any beta tester their source and NOT a binary module, then not only do they comply with all licenses, but their "closed" beta just became open to the public.
And yeah, I think monraaf has it spot on that distributing a binary-only module whose source is a derivative work of a CDDL work indeed violates the CDDL. IANAL though.
The arrogance of this project astounds. It stinks of imminent failure as soon as these guys run out of money. Either that, or they'll get sued into oblivion by the SFLC. Good question, though: has the CDDL ever held up in court? The GPL has, in at least one jurisdiction I can think of, but I don't recall the CDDL ever being tested anywhere in any sort of litigation.
- The developers come on Phoronix and make angry ad-hominem attacks to users who attempt to refute their arguments. They make sweeping generalities about other ZFS implementations, then they tell us -- while their code is still in the development stages -- that it is going to be many times faster than anything we've seen. We have been down this road before. It's all well and good to claim that you have something great coming down the pipe, but to then attack the projects that compete with you, without providing any evidence that your product is superior, is an extremely unprofessional blunder.
- Then they say it will be open source, yet closed. It's like they want the control of a proprietary product, along with the good PR of an open product. You can't have both, especially not with the license your work is derived from. Pick one!
- Distributing the binary-only module without source may violate the CDDL, because the CDDL is actually a rather good copyleft license (see here for details). It is noteworthy that, although both the GPL v2 and the CDDL 1.0 are copyleft licenses, they are incompatible in the same way that a GPLv2-only work and a GPLv3-only work are incompatible.
- While presumably an individual would be allowed to link a CDDL module into the GPL Linux kernel, I believe that doing so makes both the kernel and the linked module non-distributable. So, in order for this to be legal at all, each user entity must build from source, and then they can't give away their binaries to anyone. The original author of the derived work is not an exception to this rule. Therefore, it can be argued that distributing the binary-only module also violates the GPL license of the kernel.
Violating the CDDL alone may not be enough to get the SFLC going after them, but they're also probably violating the GPL. There is a lot of history of binary modules being distributed for the Linux kernel, though, and a lot of them are licensed under more restrictive licenses than the CDDL. I know at least a few core kernel developers who consider these binary modules to be a derivative work, and therefore violating the GPL; I happen to agree with them. If you disagree, that's fine; but the case about their violating the CDDL is a much stronger claim (from what I can tell) than the case regarding their violating the GPL.
And if they think they're going to sell this thing as a closed source product, effectively commercializing the derivative work of two incompatible copyleft licenses in a way that definitely violates one and possibly violates the other, they're in for one hell of a lawsuit.
KQ Infotech is doing something illegal. You can not distribute these pre-compiled modules. Its a direct and blatant violation of CDDL.
I will stay away even if they give me double the speed of zfs-fuse!
And looking at the missing features list, I think I am glad I am using zfs-fuse, which is much closer to upstream development. And I get to see and review the code.
It doesn't matter if you're giving binary copies to your mother. The strictest legal interpretation of copyright law would say that any copies sent outside of the legal entity "KQ Infotech" are distributed; all distributed copies fall under the scope of the CDDL. And no, they can't arbitrarily change the license their code is under, because they are creating a derivative work whose license says that derived works have to be under the same license. That's copyleft.
To make this legal, KQ Infotech would have to employ their beta testers. The legal definition of "employ" may depend on jurisdiction, but presumably it involves monetary compensation in exchange for labor. You can't be employed by someone for free. Labor laws such as minimum wage come into play.
Now, I haven't done a careful reading of the CDDL to determine if it would work out the same there, but you said "licenses like CDDL and GPL", so at least for the GPL case it is a breach of license to convey a copy of the binaries without also conveying a copy of the source.
As the original author of the derivative work, your entity has three choices that do not breach the terms of a typical copyleft license such as the GPL:
1. Don't distribute the work to any other legal entity at all. This is always legal.
2. Distribute source code only, under the same license, which allows and requires any recipient entities to follow the same license terms.
3. Distribute source code and binaries, where the binaries are built directly from the sources without modification. The various copyleft licenses do take some pains to clarify in legal terms exactly what it means to have a binary that is directly built from a given set of unmodified sources, but I'm being a wee bit sloppy here.
Each time KQ Infotech makes a copy of either the source or binaries, if they wind up in the possession of a person who is not also legally employed by KQ Infotech, then the transfer of this copy is called "conveying" or "distributing" the copy to that person. This distribution falls under the terms listed above. KQ Infotech seems to be making up a fourth, incorrect possibility, which says something like "Distribute binaries without source code." But if this were possible, the legal effect of copyleft licenses would be completely compromised, and it wouldn't be copyleft at all.


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The Nike Free Run+ 3 blends the strengthening and injury-prevention benefits of barefoot running with the comfort and protection of a running shoe. Breathable mesh and multi-layer upper provides a lightweight, second-skin-like fit. Adaptive fit midfoot construction brings customizable comfort. Sculpted Phylite™ midsole/outsole adds lightweight support and cushioning. Deep Nike Free sipes enhance flexibility for a barefoot-like ride. BRS 1000™ carbon rubber heel and environmentally preferred rubber offer durability. Waffle® piston outsole enhances cushioning and response. Removable insole. Wt. 7.1 oz. |


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Perplexus Epic
8 years & up. A whole new level of perplexing challenges! The Perplexus Epic is s a brand new challenge that requires even more concentration and skill when moving a small marble around 125 challenging barriers in a clear ball. This game is a very different experience from the traditional flat surface mazes that generally consist of one path.
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Hello Guest / Join / Sign In / Get Desura
Depth Hunter offers 25 exciting missions in which players will hunt different fish species and face the difficulties of breath-holding spearfishing, an ancient fishing method. Players will also have to find treasures, meet predators and get the possibility to take underwater photos to capture the beauty of the simulated, detailed and lively underwater worlds they're exploring also in a free mode. The game supports motion controllers, such as the Razer™ Hydra® system.
Languages: English, French, German, Italian, Spanish
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text:
Polo Ralph Lauren Ethan Pleated Short
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Polo Ralph Lauren Ethan Pleated Short
Color: | |
Size: | |
Subsize: | |
Brand: | POLO RALPH LAUREN COR |
Style: | 59882-ADIW |
Our Price: | $85.00 |
Crafted from season-spanning stonewashed cotton twill, this essential short is designed with a pleated front.
Machine wash.
Double forward pleats at the front.
Sits at the natural waist.
Eased fit through the seat and thighs.
Straight-leg silhouette.
Standard-rise belted waist with interior chambray piping.
Zip fly with a buttoned closure.
Angled pockets at the hips.
Coin pocket at the right wais.t
Buttoned welt pockets at the back.
Ralph Lauren's signature "Polo" woven label accents the back right pocket.
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text:
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Pleasantville, NJ 08232
Your Adventure Begins Here
Shop at Kerbeck Subaru for professional service and low prices. We're recognized as the new Subaru dealer Atlantic City, Toms River, Cape May Court House, and Pleasantville NJ drivers prefer. Each member of the Kerbeck Subaru sales staff is a Subaru expert and is here to make buying your new car as easy as possible. We have so much information to share with you about the exciting new line-up of Subaru cars available at our showroom in Pleasantville, so make sure you stop in! Visit us today at Route 9 and Black Horse Pike, or call us.
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*In transit means that vehicles have not yet arrived at your dealer. Images shown may not necessarily represent identical vehicles in transit to your dealership. See your dealer for actual price, payments, final accessories, expected delivery date and complete details.


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To help America's children develop healthy habits that can last a lifetime, health care providers, parents and caregivers, educators, and community leaders are encouraged to use the Department of Health and Human Services' (HHS) resources available through the President's Council on Fitness, Sports and Nutrition, Centers for Disease Control and Prevention, National Institutes of Health's We Can!! (Ways to Enhance Children's Activity & Nutrition)® program, and Let's Move! initiative.
In addition, several new public-private partnerships are being launched across the nation to ensure that all kids experience the positive health benefits of daily physical activity and healthy eating. For example, the Partnership for a Healthier America and Olympic Team USA's recently committed to provide 1.7 million kids the opportunity to participate in free and low cost physical activity programs offered by the United States Olympic Committee (USOC), USOC National Governing Bodies for sport, and others over the next year.
Over the past 30 years, the childhood obesity rate in America has almost tripled. According to the CDC, in 2010, approximately 17% of children and adolescents aged 2-19 years were already obese.
According to the 2008 Physical Activity Guidelines for Americans, children and adolescents aged 6-17 years should spend 60 minutes or more being physical active each day.


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Guidebooks only tell a miniscule portion of Mexico's story. Beyond the infinity pools and mega-resorts lies a country as ancient, complex and mysterious as its Mayan ruins. The spirit of Mexico lives on in centuries-old cathedrals, spritely street vendors and colorful outdoor markets. From the densely populated Mexico city to water wonderlands Cancun, Cozumel, Puerto Vallarta and Los Cabos, a novel's worth of experiences awaits, whether you're craving the arts, adventure, food or la playa.
Leave it to Orbitz to map out your Mexico vacation with top 10 attractions, the best time to go and insider tips. And then let's all pour ourselves a shot of tequila.
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San Diego | Los Cabos | Wed, May 13 - Sat, May 16 | $180 |
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Tijuana | Guadalajara | Mon, Sep 14 - Wed, Sep 30 | $199 |
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Model | #1285 |
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Use crickets with greater ease less loss. this product features a tubular shape flexible funnel to deliver crickets one at a time. Cricket loading is simple with Frabill's sliding bottom access lid.


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Hit TABS to search All ESCORT-POST LISTS in LAS VEGAS |
*Legal: GLN uses licenced NX-PORTAL Technology to provide an undifferentiated view into the WEBSITES OF ORIGIN. GLN does NOT CENSOR nor MONITOR any of the Source Sites' contents and does not assume responsibily for any of the contents displayed therein. - NX-PORTAL Technology is property of DUCKRABBIT TECHNOLOGIES INC.


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Stephen P. Halbrook Discusses Nazi Gun Control on The Steve Malzberg Show Recorded: Thursday, October 16, 2014
Research Fellow Stephen P. Halbrook, author of Gun Control in the Third Reich: Disarming the Jews and Enemies of the State appeared on the Steve Malzberg Show on NewsMax TV. Halbrook spoke about his recent book outlining the gun control methods employed by the Weimar Republic and the Nazi regime.
Experts: Stephen P. HalbrookType: TelevisionIssues: Civil Liberties/ Human Rights, Crime, Freedom, Government Power, Gun Control, History (International), Law Enforcement, Political Ideology and Philosophy, Race Issues
The Supreme Court and the Battle for Second Amendment Rights Recorded: Thursday, July 22, 2010
In June 2008 the U.S. Supreme Court handed down a landmark ruling on the Second Amendment individual right to keep and bear arms with its Heller v. District of Columbia decision. Two years later, in June 2010, a second historic decision squeezed through the highest court in the land.
Experts: Stephen P. Halbrook, Donald E. J. Kilmer Jr.Type: Independent Institute EventIssues: Bureaucracy and Government, Civil Liberties/ Human Rights, Constitutional Law, Criminal Justice/ Prisons, Culture/ Society, Gun Control, History (U.S), Law Enforcement, Litigation, Political Ideology and Philosophy, Race Issues


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Surfboard Corkboard
- Overview
Organize in style with this beachy design. Shaped like a long board, it's the best place to post pics, notes and tide schedules.
- 14.75" wide x 59.75" high x 1" thick
- Made of MDF and cork.
- Keyhole backing.
- Mounting hardware included.
- Dimensions + Care
- Wipe with a soft, dry cloth.
- Shipping Info
- Please allow 5-7 business days for delivery. Delivery estimate includes monogrammed and gift-wrapped items.


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Everyone wants a piece of the new girl in town, but nothing turns Kakufu on more than a brutal street fight. She shrugs off her shredded skirts and tattered tops with a flurry of busty badassery while fighting to unite seven rival schools. And with no shortage of enemies, why take on one guy when she can take on ten? In this adventure where teenage brawlers are guided by jewels infused with the spirits of ancient warriors, Kakufu is content to flash her panties and crack some skulls. But like any hero, she cannot escape her destiny - no matter how dark it may be.
Contains episodes 1-13.
Spoken Languages: English, Japanese, English subtitles.
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UN.GIFT Publications
IBCR Training Manual on Trafficking in Children
Sep 30 2010
Download right click "save as"
The IBCR is an international non-governmental organization based in Montreal and created in 1994. Its principal mission is to contribute to the promotion and respect of the Convention on the Rights of the Child (CRC) and its optional protocols.
This training manual focused on the capacity building of trainers to better identify youth at risk of trafficking and to provide adequate interventions. The training is based on a participatory approach that encourages an active discussion and exchange of information on behalf of every participant.
Here are the different modules of the training in French:
Activités Jeunesse
Jeux : à vos risques.
Jeux : dans la peau de…
Jeux : la loi c'est la loi.
Jeux : la vérité je le jure.
Jeux : l'impro des pros.
Module 1 : traite (contenu pratique)
Module 1 : traite (contenu théorique)
Module 2 : traite (contenu pratique)
Module 2 : traite (contenu théorique)
Module 3 : traite (contenu pratique)
Module 3 : traite (contenu théorique)
More about IBCR.
- 2014 Global Trafficking in Persons report - full
- US State Department Trafficking in Persons Report 2014
- 3rd General report on GRETA's activities
- Walk Free Global Slavery Index 2013
- UNESCO: Model curricula for journalism education: a compendium of new syllabi
- IOM: A Situational Analysis of Aruba's Response to Human Trafficking
- Report by OSCE Special Representative and Co-ordinator for Combating Trafficking in Human Beings, following her visit to Bosnia and Herzegovina, 12-14 June 2012
- Current Status of Victim Service Providers and Criminal Justice Actors in India on Anti-human Trafficking
- OSCE: Trafficking in human beings for the purpose of organ removal in the OSCE region
- OSCE: Trafficking in Human Beings Amounting to Torture and other Forms of Ill-treatment
- Report of the Special Rapporteur on trafficking in persons, especially women and children, Joy Ngozi Ezeilo
- Policy and legislative recommendations towards the effective implementation of the non-punishment provision with regard to victims of trafficking


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Product Sonification
We spoke with Karel Barnoski, an award-winning audio designer who has integrated sound into products and experiences ranging from stoves to cameras. Karel shares his keen insights about how the language of sound relates to interaction design and UX, and about the power of audio to connect users to brands and products.
- Q: Karel, your company, 2octave, is very unique. Can you give our readers an overview of your work and how it relates to user experience and interaction design?
- A: 2octave specializes in product sonification, audio branding, and audio strategy. We design audio as an integral part of the user experience. Our work is tied to how people interact with the world around them, whether it's an environment, an interface, or a product like an appliance or camera.
- Sound is a critical aspect of the user experience that's been sorely overlooked. Strategic use of sound can improve a product's usability and enhance the impact of a brand. Sound appeals to our emotions, and can be leveraged to connect users to a brand even when they aren't looking at a product.
- Q: Can you tell us about your background and how you got involved with this field?
- A: The seed was planted when I took my first piano lesson at the age of 8. I'm 31 now, so that's about 23 years of playing piano—classical, jazz, rock, blues, etc.
- In college, I majored in visual design and minored in music theory. I combined my visual and musical ideas for many of my class assignments, which is when my two interests became one. After college, I started working at Kodak as a visual interaction designer, but there were many initiatives at Kodak that gave me the opportunity to design custom music, sound effects, branded pieces for kiosks, interactive Web applications, and product prototypes.
- Q: From your perspective and experience, how much can sound impact a user's perception of a product, software application, or service?
- A: Without getting too deep into human perceptual psychology, sound is perceived much in the same way as other stimuli. By manipulating sound you can effect the user's perception of an experience. Through sound, you can make a product be perceived as elegant, simple, complex, etc. Therefore, it's essential to design the audio experience parallel with the other aspects of the product, otherwise there might be a disconnect between the auditory and visual experience for the user.
- If a product sounds elegant, users are going to perceive that product as elegant. If it sounds cheap and crude, like the sound was thrown in at the last minute, that's the way users are going to perceive the rest of the product.
- Q: How and when do you get involved in the client relationship and how do you get customers to understand the business value of sound?
- A: Establishing a relationship with a project's stakeholders generally starts with marketing and human factors. There are proven methodologies for how a sound is designed that leads to better usability of a product, and the same is true for return on investment. Most marketing folks I am engaged with understand the value of a well-designed product. Therefore, it's easy for them to see the importance of sound as piece of the product design puzzle.
- Q: Can you give us some examples of your sound design successes both in terms of execution and from a business perspective?
- A: The first example is an "Audio Brand Language" initiative I did for a major appliance manufacturer that was successful because it was validated through consumer testing. A set of branded audio assets was designed for a group of brands. Consumer testing results showed that the sounds were aligned with the attributes of each respective brand image.
- Another example is Kodak's V-Series camera, which is considered the forerunner and leader of the Kodak Easy Share camera product line. When the series was first released, it was dubbed the "James Bond" camera. I worked with Kodak's creative team to design a sound experience that echoed the camera's sleek James Bond style. When you turn the camera on, the power-on sound reminds you of a James Bond movie soundtrack. All the functional sounds that communicate user actions are derived from that central theme, so the entire user experience is unified.
- Q: Can you give us some examples of great sound experiences in different areas of our lives today?
- A: The first experience that comes to mind is Guitar Hero because it's a perfect combination of sound and user interaction. Overall, video games have the best sound experiences found in any product today.
- As far as devices go, the simplest yet most effective sound I've heard is the iPod click. Without looking at the interface, the click tells me if I'm going up or down in a menu. It also increases and decreases in volume as you change the volume of the current song. It's easy to take the click for granted until you turn it off and try to navigate.
- Skype is a good example of effective sound in a software application. It has a playful feel without being overly cartoonish, cliched, or annoying. When I use Skype, the sound of an incoming call never seems to bother me. Remember this: when you use a product, any product, if you turn off the sound, it wasn't well designed.
- In regards to environmental sound experiences, I think of the tunnel between Terminals B at C at O'Hare Airport. There, at one of the busiest airports in the world where people are under all kinds of stress, I always feel better after I ride the walkway through that tunnel. It's almost spa-like with ambient sounds cross fading in and out as the user travels down the tunnel.
- Finally, there's the classic audio signature of the Harley Davidson exhaust system. When you hear that rumbling sound, you know it's a Harley.
- Q: Are organizations looking at product sonification as a competitive advantage in terms of user experience?
- A: Absolutely. It's been a slow process, but in the global marketplace, organizations continually seek a competitive edge, and they are starting to see sound as a medium that has been undervalued. Marketers and designers are starting to see sound as an important point of differentiation.
- Look at mobile devices, appliances and cars—any product that a potential buyer can interact with at the point of sale. I've seen a refrigerator in a showroom that was not working, so there was no audio or visual feedback, not even a hum. Next to it was a similar model at the same price point that was plugged in and working. Naturally, more shoppers were opening and closing that product's door. When more people interact with products at the point of sale, the potential for selling goes up.
- Q: Beyond some of the business drivers, what are the significant technological factors behind this revolution, and how do they affect your work?
- A: In recent years, audio technology has improved similar to computer processing. As a result, the price per unit continues to decrease. In mass production, even minimal savings per unit equates to millions of dollars saved.
- I categorize audio playback technology into three main groups: pure tones, MIDI, digital audio. The cheapest and simplest solution is pure tones, like a monophonic chime created by a piezo. The second group is MIDI. MIDI technology is flexible and efficient. MIDI files take up very little memory on a device.
- Digital audio is the third audio playback technology group. Unlike pure tones and MIDI, digital audio files, such as MP3, allow for endless sonic possibilities. Think of the Intel sound, which has 300 layers of sound, and how dynamic that sounds compared to a pure tone.
- Sound technology is on a bell curve and is ramping up so fast it seems like every two or three years there's a new compression scheme that's half the size and twice the quality, and it's cheaper.
- Q: Do your techniques for conceiving and developing sound concepts parallel the visual design and creative development processes that would be familiar to our readers?
- A: 75% of my process is a one-to-one correlation to that of a visual designer. Just like working in the visual design process, I study the requirements and digest the creative brief and overall direction. Then I sit down and make audio sketches, just like a designer might make on paper.
- Sound sketching for me means working quickly to let ideas flow in a stream of consciousness. I come up with a hundred different quick melodic ideas and then start to refine them into sets of themes to recognize patterns—almost like an image board to refine colors and shapes, but with music, it's about timbre, tempo, and other attributes that make sound unique. Next, I choose sketches that align with the overall creative direction of the project, make iterations, and take "comp" to the design team. Once we agree on a final theme, I build the audio assets that go into the product or interface.
- Q: How does your process differ from the visual design process?
- A: As far as the creative process goes, the differences are slim. But, when you get into the production end of it, there are huge differences in the technical aspect of the process. Obviously, the software and the techniques I use to produce the final assets are quite different. But the idea that you optimize your final assets for integration is the same. It's just that the tools are different to get to the final deliverable.
- Q: Much of what you do is on the bleeding edge. What industries or verticals use product sonification most effectively?
- A: There's an evolving need in appliances as they become more and more interactive. In general, the experience in one's home, especially in the kitchen, is an area that is growing fast. Another area I haven't worked in, but I think is going to be huge, is the medical field. There is room for improvement in patient care both from a usability and experience standpoint. This includes the sounds devices make, the way technicians retrieve information, and the like. I've got some good ideas of how this experience can be improved through sound.
- Mobile devices, especially cell phones, are on the bleeding edge because they're based on communication through sound. Phones are small devices that demand high quality sound output. Therefore, more effort has been put into these products than, say, appliances. Automotive is also a growing market. As the interfaces in vehicles improve in audio playback and the types of interactions people are having increase in complexity, there is going to be a greater need for a cohesive experience with those interfaces that align with the brand image of the vehicle. Lastly, environments where there is a lot of secondary noise like airports, subways, and other mass transit systems are ripe for sound design. It's going to be a real challenge to improve those environmental situations from an audio perspective.
- Q: What does the five-year horizon look like to you?
- A: The big picture is really exciting. It's actually hard to imagine how far this field could go because, like computing, 10 years ago it was a totally different landscape. But, from a business perspective, as technology becomes cheaper and generates higher audio quality, I think more businesses will embrace audio as an integral part of their product design roadmap.
- You're going to see more and more people get into the field of sonification and you're going to see the awareness and the quality improve. It's a revolution because a lot of this technology is so accessible. You don't necessarily need a music studio. You just need a laptop, software, and a good understanding of design to produce good results.
- Karel, thank you very much for a fascinating conversation.
- It's been really interesting for me, too.
This article was originally published on the User Interface Resource Center (UIRC). For more info, please see http://uxmag.com/uirc
Add new comment
I have a lot of experience creating sound and putting sound into games and video and I still think I learned some things from this interview. I like the approach the interviewer has taken, good job!
@ Jeremy Olson - Glad you enjoyed the article. Thanks for sharing your insight and examples!
@ Deaf User - By accessible I meant the ability to create professional sound without the use of big studios. I appreciate your point of view.
P.S. I meant by making videos and podcasts accessible online is to add captions and transcripts - they would also increase SEO and ROI for website owners, by the way.
"You're going to see more and more people get into the field of sonification and you're going to see the awareness and the quality improve. It's a revolution because a lot of this technology is so accessible."
Accessible to whom?
There are more than 36 million of deaf and hard of hearing users in the USA (10% of total population) and I am one of them. We have been really frustrated with an increasing number of videos and podcasts that are not accessible to us - even though they are required by the disability laws and W3C guidelines, just like adding "alt" attributes to images.
The sound is not accessible to those who have no speakers, are in noisy/quiet environments, etc.
Keep in mind that much of what Karel is talking about is with respect to actual physical product - i.e., mobile or handheld devices and consumer electronics for the home.
In those cases sound is being utilized as an additional interaction affordance, reinforcing the visual behavior portrayed on the screen. In that sense, it is a redundant affordance put in place to enrich the experience by engaging an additional sense. The usability of a given device is not lessened if that affordance is not percieved.
Great read, thanks! As you said, I think sound can really contribute to great user experience. It touches us emotionally in ways that other mediums never could—recall the times when you hear that song that you used to always listen to as a kid. Coming from the iPhone scene, I think it is one of the most neglected and most powerful tools when it comes to UX.
A few examples that I like personally (and a lot of this may have to do with personal preference): Tapbots apps all have subtle sound effects that make their apps that much more fun to use (http://www.tapbots.com) and, while maybe annyoing to some, I really like the page flip sound in Classics (http://www.classicsapp.com).


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Kwik Goal Training Arches
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Finish Line Launches Support of Special Olympics and its New TRAIN Athlete Sports Assessment and Nutrition Education Program
The Finish Line, Inc. (NASDAQ: FINL) and its Finish Line Youth Foundation announced today a multi-year pledge to support Special Olympics as part of the retailer's ongoing mission to celebrate the everyday achievements of athletes everywhere.
Finish Line will support Special Olympics through multiple opportunities, including:• Employee activation and volunteer participation in 2012 Special Olympics Summer Games in Indiana as well as the Chicago and Atlanta markets in year one and additional markets nationwide in coming years.• Serving as the first national sponsor of Special Olympics' new TRAIN program—a first of its kind sports assessment and nutrition education program designed to help athletes stay active, stay healthy, and achieve their personal best. In addition to helping to finance the program, Finish Line employees will help activate the TRAIN program for Special Olympics athletes in key markets. • Sale of specific merchandise in Finish Line's more than 635 stores and online nationwide beginning with the 2012 back-to-school shopping season to benefit Special Olympics.• An in-store and online holiday season customer and employee donation program to benefit Special Olympics.
"Finish Line has always supported worthy non-profit organizations, yet we searched for some time to identify a single signature cause that our employees, customers, and vendors could help us rally around in a meaningful way and make an enduring impact," said Chairman and Chief Executive Officer Glenn Lyon. "Special Olympics is the one organization that our customers and employees cited in recent independent research as a cause that they are not only passionate about, but that also suits our brand particularly well. Finish Line is all about having fun, being active, and helping everyone reach their own finish line, whether it means competing as a Special Olympics athlete or playing college intramurals. The added opportunity to be the only national sponsor of the TRAIN program is exciting as this is a true breakthrough in assessing, developing and tracking sports skills among individuals with intellectual disabilities. This program will contribute to the overall health, fitness and quality of life for individuals with intellectual disabilities and we are thrilled to help take it to the next level through our support."
"This partnership is a great fit for us," said Dr. Timothy P. Shriver, Chairman and CEO of Special Olympics. "We are a sports organization and Finish Line is a great sports brand with a passion to celebrate the achievements of athletes everywhere. Their mission is a testament to the power of what Special Olympics athletes have shown time and time again – that we are all true champions and each of us has the ability to reach our own personal best. Finish Line's commitment to supporting our athletes with intellectual disabilities will be a tremendous asset as we continue to work to promote acceptance and inclusion for all people."
TRAIN-Special Olympics' First National Effort to Collect and Track Data on Sports Skills among Those with Intellectual DisabilitiesTRAIN (Testing Recreational Activities and Improving Nutrition) is a new sports assessment and nutrition education program developed by Special Olympics as one response to the fact that individuals with intellectual disabilities are more likely to develop a sedentary lifestyle, yet have the same fitness capacities and needs as those without a disability. A TRAIN assessment takes place when Special Olympics athletes complete a variety of fun physical fitness challenges at designated stations, such as the 10-meter run, the vertical leap, and balance test. Each athlete's results are captured and entered into a specially-designed computer program, which produces a report highlighting the strongest skills and pinpointing which sports the athlete may be most successful pursuing as well as skills that could be improved through regular, at-home exercise. The program also tracks data on each athlete to illustrate progress over time. TRAIN is the first comprehensive program Special Olympics has ever used to collect and track data on sports readiness skills among individuals with intellectual disabilities. Special Olympics is using the data from TRAIN events to develop new scientific norms and better advice for Special Olympics athletes and coaches as they work toward being more successful in their sport as well as more fit and healthy overall.
Video and Photos/Multimedia gallery available at:http://www.businesswire.com/news/home/20120417005576/en/Finish-Line-Special-Olympics-Announce-Multi-Year-Partnership
The Finish Line, Inc. is a premium retailer of athletic shoes, apparel and accessories. Based in Indianapolis, Finish Line has more than 635 stores in malls across the United States, employing more than 11,000 associates who help customers every day connect with their sport, their life and their style. Online shopping is available at www.finishline.com and mobile shopping is available at m.finishline.com. Follow Finish Line on Twitter at Twitter.com/FinishLine and "like" Finish Line on Facebook at Facebook.com/FinishLineUSA. The company also operates, through a venture with Gart Capital Partners, the Running Specialty Group, which has 19 specialty running shops in seven states, and the District of Columbia under The Running Company banner. More information is available at www.therunningcompany.net.
Finish Line Youth Foundation, a not-for-profit organization, provides financial support for community-based youth athletic programs and camps for disadvantaged and special needs children across the United States. Since its inception in 1998, the Finish Line Youth Foundation—the philanthropic outlet for Finish Line—has helped build a legacy for all Finish Line employees and makes a difference for young people in the communities it serves. Throughout the past 14 years, the Finish Line Youth Foundation has granted more than $4.5 million to not-for-profit organizations that support its mission.
Special Olympics is an international organization that changes lives through the power of sport by encouraging and empowering people with intellectual disabilities, promoting acceptance for all, and fostering communities of understanding and respect worldwide. Founded in 1968 by Eunice Kennedy Shriver, the Special Olympics movement has grown from a few hundred athletes to nearly 4 million athletes in over 170 countries in all regions of the world, providing year-round sports training, athletic competition and other related programs. Special Olympics now takes place every day, changing the lives of people with intellectual disabilities all over the world, from community playgrounds and ball fields in every small neighborhood's backyard to World Games. Special Olympics provides people with intellectual disabilities continuing opportunities to realize their potential, develop physical fitness, demonstrate courage, and experience joy and friendship. Special Olympics continues to grow thanks in part to the support of global corporate sponsors including The Coca-Cola Company, Procter & Gamble, Hilton Worldwide, Mattel and Lions Club International. Visit Special Olympics at www.specialolympics.org. Engage with us on: Twitter @specialolympics; fb.com/specialolympics; youtube.com/specialolympicshq, and specialolympicsblog.wordpress.com
Anne Roman Finish Line (317) 613-6577 email@example.com
Mandy MurphySpecial Olympics(202)-email@example.com
Special Olympics transforms athletes' lives through the joy of sport. Help us make a difference.
Volunteering with Special Olympics is fun and very rewarding, for both the athlete and the volunteer!
Stay in touch! See inspiring stories, photos and videos in our Special Olympics newsletter.
Today, the Templeton Foundation gave its most prestigious award to my hero, Jean Vanier. For Linda and our children and me, he has also been our retreat leader, our teacher of humility, our guide.
Posted on 2015-03-11 by Tim
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Case, M., Matheson, E., Minto, L., Hassan, R., Harrison, C.J., Bown, N., Bailey, S., Vormoor, J., Hall, A.G. and Irving, J.A.E.
Notes: The authors of this study investigated the relationship of somatic mutations that deregulate the RAS-RAF-MEK-ERK pathway and Acute Lymphoblastic Leukemia (ALL) and its progression to relapse in some patients. They show that such mutations are common in ALL and its recurrence. Furthermore, lymphoblasts from patients with mutations that were associated with upregulation of ERK showed increased cytotoxicity over wild-type controls when treated with U0126, suggesting that specific ERK inhibitors may eventually yield useful therapeutics. Following drug exposure, cytotoxic effects were assessed using the CellTiter 96® AQueous One Solution Cell Proliferation Assay. (3905)
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CellTiter 96® AQueous One Solution Cell Proliferation Assay
MEK Inhibitor U0126
Joo, J.H. and Jetten, A.M.
Notes: This article showed that expression of several immune response genes could be induced in lung adenocarcinoma H460 cells by treatment with farnesol and that this induction proceeds through an NF-κB pathway. To determine which MAPKs were involved in the activation of these genes, the authors used the MEK inhibitor U0126 and showed that it inhibited the expression of several of the immune response genes and specifically inhibited the phosphorylation of p65 on Ser276. (3904)
Maekawa, M., Yamamoto, T., Kohno, M., Takeichi, M. and Nishida, E.
Notes: The authors of this study investigated the role of ERK1/2 kinase signaling in the preimplantation developmental events that precede compaction and blastocyst formation (2-cell to 8-cell stages). The MEK inhibitor U0126 was added to 2-cell stage mouse embryos, and the embryos were observed to arrest at the 4-cell stage. The arrest was reversible, but experiments indicated that ERK1/2 signaling is required for M-phase progression in early cell cycles during mouse development. (3906)
Wang, Z., Xu, J., Zhou, J-Y., Liu, Y. and Wu, G.S.
Notes: Mitogen-activated protein kinase phosphatase-1 (MKP-1) negatively regulates MAPK signaling and may have a role in cell survival in response to stress stimuli, including chemotherapeutics. This study investigates its role in cisplatin resistance. MAPK inhibitors U0126 (MEK inhibitor) and SB 203580 (p38 inhibitor) were used to determine whether the ERK pathway is required for cisplatin-induced MKP-1 expression in human lung cancer (H460) and human ovarian cancer (OVCAR3) cells. (3529)
Philipova, R., Larman, M.G., Leckie, C.P., Harrison, P.K., Groigno, L., and Whitaker, M.
Notes: The authors of this study sought to determine whether both MAP kinase and Cdk1/cyclin B kinase are required for mitotic entry and calcium signals in early sea urchin embryos. Treating embryos with MEK Inhibitor U0126 12 minutes after fertilization inhibited MAP kinase activity in the early embryos. Anti-ACTIVE® MAPK pAb was used for immunoprecipitation of active MAP kinase at various times after fertilization. (3506)
Anti-ACTIVE® MAPK pAb, Rabbit, (pTEpY)
Cancedda, L., Putignano, E., Impey, S., Maffei, L., Ratto, G.M. and Pizzorusso, T.
Notes: Promega's MEK Inhibitor U0126 was used to demonstrate specific CRE-mediated gene expression through Erk activation in mouse brains. An osmotic minipump pumped 250μM U0126 into animals before brain sections were dissected and examined for CRE-linked beta-galactosidase reporter in X-Gal histochemical studies. (2795)
Reimann, J.D.R., Jackson, P.K.
Notes: Vertebrate eggs arrest at meiosis II; CSF (cytostatic factor) acts antatgonistically to anaphase promoting complex (APC) and maintains this arrest and prevents parthenogenetic activation in eggs prior to fertilization. Emil was identified as an inhibitor of APC. The authors used Mek Inhibitor U0126 to determine if the MAPK signaling pathway is required for maintaining the CSF arrest. Adding U0126 to CSF extracts led to inactivation of MAPK and p90rsk but did not release extracts from the CSF arrest. The authors conclude that the MAPK pathway is not required to maintain CSF arrest. (2432)
Chou, T.T. , Trojanowski, J.Q., Lee, V.M.Y.
Notes: Treatment of the human medulloblastoma MED283 cells with NGF causes a reduction is cell viability over a 72-hour period as judged by the CellTiter 96® AQueous Cell Proliferation Assay. The death was due to apoptosis. Neither the PD98059 inhibitor nor the MEK Inhibitor U0126 could prevent the apoptosis. The inhibitors (50µM and 10µM, respectively) were added to the media, which was changed every 12 hours during the 72-hour period. Cells with inhibitor and no NGF were not apoptotic, nor was there any noticeable decrease in cell viability. The data for the MEK Inhibitor U0126 Inhibitor is not shown. (1296)
CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay
Walter, S.A., Guadagno, S.N., Ferrell, J.E.Jr.
Notes: The MEK Inhibitor U0126 was used to further define the role of MAPK activation in the timing of mitosis in a fertilized egg. The U0126 Inhibitor prevented MAPK activation and the calcium-induced H1 kinase activation and nuclear envelope breakdown occurred approximately 30 minutes earlier than in control cells. It is also known that there is a transient activation of MAPK during mitosis following cdc2 activation. Addition of the U0126 Inhibitor did not change the cdc2 activation or mitosis and paralleled vehicle only controls. (0195)
Takeda, K., Hatai, T., Hamazaki, T.S., Nishitoh, H., Saitoh, M., Ichijo, H.
Notes: The MEK Inhibitor U0126 was shown to inhibit MAPK phosphorylation completely and to a greater extent than PD98059. The inactivation had very little effect on neurite outgrowth. MAPK phosphorylation was determined with the Anti-ACTIVE® MAPK pAb by Western blotting. (0297)
Pizzorusso, T., Ratto, G.M., Putignano, E., Maffei, L.
Notes: Cultured rat neurons were treated with BDNF with or without preincubation with 50uM U0126 MEK Inhibitor. The U0126 Inhibitor blocked both MAPK phosphorylation and CREB phosphorylation. The assay used to judge the phosphorylation was a immunohistochemical technique that used a confocal microscope and image processing software to measure the mean fluorescence from the microscope's field. (0536)
Lee, S.J., Zhou, T., Choi, C., Wang, Z., Benveniste, E.N.
Notes: Primary mouse astrocytes were treated with an anti-Fas antibody, which induced expression of chemokines. Pretreatment of the cells with the U0126 MEK Inhibitor 30min prior to a 1hr treatment with the antibody reduced chemokine mRNA to basal levels. Neither oloumoucine or SB202190 (p38 inhibitor) duplicated the inhibition. (0818)
Herbert, T.P., Kilhams, G.R., Batty, I.H., Proud, C.G.
Notes: The MEK Inhibitor U0126 could interfere with the eIF4F assembly presumably through interference with phosphorylation of the components. The inhibitor blocked ERK phosphorylation in phorbol ester treatment with a 45-minute pretreatment with 50µM MEK Inhibitor U0126. Twenty micromolar MEK Inhibitor U0126 did not fully block phosphorylation. (1037)
Lawlor, M.A., Feng, X., Everding, D.R., Sieger, K., Stewart, C.E. and Rotwein, P.
Notes: The MEK Inhibitor U0126 was used to inhibit constitutive activity of Mek1 in order to determine which growth factors are necessary for C2 muscle cell line viability. U0126 was used at a 10 micromolar concentration. (2165)
Bates, M.E., Green, V.L. and Bertics, P.J.
Notes: The MEK Inhibitor U0126 was shown to inhibit MAPK activation in human eosinophils. IL-5-induced leukotriene C4 release was inhibited. The inhibitor was preincubated with the cells for 1 hour prior to addition of IL-5. Activation of MAPK was followed with the Anti-ACTIVE® MAPK pAb via western blotting. (1467)
Hoffert, J.D., Leitch, V., Agre, P., King, L.S.
Notes: The protein aquaporin-5 is upregulated by osmotic shock in MLE-15 mouse lung epithelial cells. The shock causes an increase in ERK activation. The activation was blocked by the MEK Inhibitor U0126. The cells were treated with both inhibitor and activator for 15 minutes prior to lysis. (1049)
Learish, R.D., Bruss, M.D., and Haak-Frendscho, M.
Notes: A primary cell line from rat subventricular zone which remains undifferentiated over time was developed as a model for MAPK activation. Cell were stimulated with 20 ng/ml bFGF and 20 ng/ml EGF (Promega) to activate MAPK. The MAPK pathway was inhibited with either U0126 (Promega) or PD98059. Immunocytochemistry was performed with the Anti-ERK 1/2 pAb (1:100 dilution) to detect both active and inactive forms of MAPK proteins and with the Anti-ACTIVE™ MAPK pAb (1:100 dilution) to specifically detect the dually phosphorylated, active forms of MAPK. Cells were also immunostained with the neuron specific marker Anti-III-tubulin mAb (0.5 µg/ml). Cell proliferation was monitored with the CellTiter 96® AQueous One Solution Cell Proliferation Assay System. Apoptosis within the cell population was monitored using the DeadEnd™ Fluorometric TUNEL System. (2391)
Anti-βIII Tubulin mAb
Anti-ERK 1/2 pAb, Rabbit
DeadEnd™ Fluorometric TUNEL System
Donkey Anti-Rabbit IgG (H+L), HRP
RQ1 RNase-Free DNase
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Schmidt, H., Schulz, S., Klutzny, M., Koch, T., Handel, M. and Hollt, V.
Notes: HEK 293 cells stably expressing the mu-opioid receptor respond to agonists by MAPK phosphorylation. Activation of the MAPK was totally inhibited by the MEK Inhibitor U0126 at 100nM as judged by immunocytochemistry. The PD98059 required 20µM for the same inhibition. (0411)
Bulleit, R.F. , Hsieh, T.
Notes: The MEK Inhibitor U0126 was tested for its ability to block the increase in expression of the GABA-Aalpha6 subunit of the GABA-A receptor. The increased expression was judged by Northern blotting. Granule cells were cultured for 48hrs in serum-free media in the presence of BDNF and various concentrations of the U0126 Inhibitor. Total inhibition of the subunit's expression was noted with only 5-10µM of the inhibitor. The inhibitor PD98059 achieved the same level of inhibition with 25-50µM. Similar studies were performed with cells incubated for only 24hr with the BDNF and U0126 inhibitor. (1372)
Wang, H.-C. , Zentner, M.D., Deng, H.-T., Kim, K.-J., Wu, R., Yang, P.-C., Ann, D.K.
Notes: Addition of exogenous H2O2 to cultured A549 cells causes a rapid increase in activated Erk as judged by the Anti-ACTIVE® MAPK pAb via Western blotting. There is an inhibition of transcriptional activation of the amiloride-sensitive epithelial sodium channel α-subunit. The inhibition is reversed by 50µM U0126 MEK Inhibitor treatment 20 minutes prior to addition of H2O2 . Reporters were used for measurement of transcriptional activity and were produced in the pGL2-Promoter Vector. The reporter vectors were cotransfected into the A549 cells with the pRL-TK Vector at a 12:1 ratio. The luciferase activities were measured with the Dual-Luciferase® Reporter Assay System. Transfections were accomplished with the ProFection® Mammalian Transfection System-DEAE-Dextran. (0200)
Dual-Luciferase® Reporter 1000 Assay System
Dual-Luciferase® Reporter Assay System
pGL2-Promoter Vector
pRL-TK Vector
Shiraishi, M., Hirasawa, N., Kobayashi, Y., Oikawa, S., Murakami, A., Ohuchi, K.
Notes: The U0126 MEK Inhibitor inhibited both thapsigargin- and TPA-induced histamine production in a concentration dependent manner.Cells were cultured in 0.1 to 10µM U0126 Inhibitor for 24hr in the presence or absence of thapsigargin or TPA. Maximal inhibition was seen with 10µM inhibitor and ~50% inhibition at 1µM. (0397)
Ku, H., Meier, K.E.
Notes: The MEK Inhibitor U0126 blocked both PMA-stimulated MAPK phosphorylation and paxillin phosphorylation in primary mouse splenocytes and thymocytes. MAPK phosphorylation was judged by immunoblotting extracts with the Anti-ACTIVE® MAPK pAb, Rabbit, (pTEpY). The MEK Inhibitor U0126 was more effective than PD98059. (0853)
Khan, K.M.F., Falcone, D.J.
Notes: Serum-starved RAW264.7 macrophages were stimulated for 15 minutes with a laminin peptide, then extracts were made and analyzed for ERK phosphorylation. The treatment increased ERK phosphorylation; in other studies, it caused increases in urokinase and matrix metalloproteinase secretion into the media. The MEK Inhibitor U0126 could block ERK phosphorylation with a 30-minute preincubation of 10µM prior to the peptide treatment. The same pretreatment could block secretion of the two enzymes. (0935)
Zheng, W.-H. , Kar, S. , Quirion, R.
Notes: The pretreatment of PC12 cells with 20µM U0126 MEK Inhibitor for 20min prior to phorbol ester and IGF-1 treatment blocked the phosphorylation of Akt kinase. To determine the effect of PKC inhibitors on PKC activity in the PC12 cells after phorbol ester stimulation, lysates were prepared from various cellular fractions and analyzed for PKC activity with the SignaTECT® PKC Assay System. Control values were obtained in the absence of the lipid activator solution and in the presence of the Myristoylated PKC Inhibitor Peptide. The greatest increase in PKC activity was found in the membrane fraction. (0058)
SignaTECT® Protein Kinase C (PKC) Assay System
Abe, K. and Saito, H.
Notes: Both PMA and dibutryl cAMP (dBcAMP) are known to cause differentiation of cultured astrocytes into process-bearing stellate cells. The U0126 MEK Inhibitor blocks the formation of stellate cells by PMA but not by dBcAMP. The cells treated with dBcAMP had the same levels of Erk 1/2 as the PMA treated cells throughout the experiment but only PMA treated cells demonstrated activation of Erk 1/2 by dual phosphorylation. Thus, it is reasonable that the U0126 MEK Inhibitor could inhibit PMA-induced stellate formation. The level of total Erk 1 and 2 was determined by Western blotting with the Anti-Erk 1/2 pAb and the level of activated Erk 1/2 was determined with the Anti-ACTIVE® MAPK pAb. Cells were treated for 20min with 10µM U0126 Inhibitor and treated with the stimulator for up to 6hr. The U0126 Inhibitor treatment blocked the stellate formation by PMA throughout the experiment. Titration of the U0126 Inhibitor was performed with 0.01 to 10µM and was compared to the PD98059 inhibitor. U0126 Inhibitor was completely inhibitory at 1 and 10µM and at 0.1µM was as inhibitory as 30µM PD98059. Protein kinase C inhibitors were also able to mimic the effect of the U0126 Inhibitor as demonstrated by the blockage of Erk 1/2 phosphorylation and stellate formation. The U0126 Inhibitor was also able to reverse the morphology of the stellate cells back to that of polygonal, undifferentiated cells. The reversal of morphology was also supported by the loss of activated Erk 1 and 2 as judged by Western blotting with the Anti-ACTIVE® MAPK pAb. (2050)
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One of two creatures native to only Antarctica. This very rare creature can be found in the Antarctic wastelands, and also in the southern parts of New Zealand and Australia, such as Tasmania.
''WOW! Look at that frert over there hiding in the bushes, he is a sneaky bugger.'' Exclaimed Robert.
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7 oktober 2012


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VP of Americas Sales for a Telecommunications Equipment Manufacturer based in Ottawa, Canada.
I have been doing sales in the Telecommunications Equipment space for 20+ years, have been at this company for 5.
This company has been the best one yet, have built a team of 30+ great folks and have grown the business significantly, plus 3 years ago started a corporate band ("The Dealmakers" - a play on the Sales thing) that we use to promote the company in our industry.
It has been awesome, has got me the opportunity to perform at some great venues such as the Rock and Roll Hall of Fame (twice!), Vegas, Boston, Nashville (BB Kings!), Park West in Chicago, and Dallas.
Pretty cool to tie my favorite hobby into work! Enjoying it while it lasts...