text:
Secret History
A survey of the site was being conducted in preparation for the building of the Forth Replacement Crossing in a field in Echline, South Queensferry, just north of Edinburgh.
Rod McCullagh, a senior archaeologist at Historic Scotland, said: "This discovery and, especially, the information from the laboratory analyses adds valuable information to our understanding of a small but growing list of buildings erected by Scotland's first settlers after the last glaciation, 10,000 year ago.
"The radiocarbon dates that have been taken from this site show it to be the oldest of its type found in Scotland which adds to its significance."
The postholes are thought to have once held wooden posts that supported the walls and roof of the building. The roof itself was probably covered with turf, archaeologists believe.
The remains of several fireplace hearths were also found inside the building and more than 1,000 pieces of flint, including arrowheads and other tools, were also found.
Other discoveries included large quantities of charred hazelnut shells, suggesting they were an important source of food for the occupants of the house.
Archaeologists believe the dwelling would have been occupied on a seasonal basis, probably during the winter months, rather than all year round.
Ed Bailey, project manager for Headland Archaeology, the company that carried out the excavation works, said: "The discovery of this previously unknown and rare type of site has provided us with a unique opportunity to further develop our understanding of how early prehistoric people lived along the Forth.
"Specialist analysis of archaeological and palaeoenvironmental evidence recovered in the field is ongoing. This will allow us to put the pieces together and build a detailed picture of Mesolithic lifestyle."
Transport Minister Keith Brown said: "This ancient dwelling, which was unearthed as part of the routine investigations undertaken prior to construction works, is an important and exciting discovery.
"We now have vital records of the findings which we will be able to share to help inform our understanding of a period in Scotland's ancient history."
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As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them.
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looks like an article fabricated to defend the sodomites....There have been reports of people being assaulted or having acidents and being...
Pure evilness. Although sott always exposes the lack of empathy and I try to get educated in psychopathy I still can't understand how a human...
i have no choice in the matter, there is no other internet provider that is in my area AND AT&T knows this, they have raised my rate every...
A turkish tourist shot a short video during the earthquake, skip the ad at the beginning. _[Link]
but I am continually struck by the age in which we live and the ability for most people on the planet to witness such barbarity, to KNOW about it....
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text:
The original deal pioneer keeps on pinching pennies and cracking wise. No, that price isn't a typo.
Go to Woot
Candlepower and puppet shows are so passé. Get the newest TVs, speakers, home theater gear, and more.
Go to Electronics.Woot
The robots are coming! And so are the laptops, the tablets, the chargers, and all sorts of other gadgets!
Go to Computers.Woot
High living at low prices with name-brand deals for your pad, crib, nest, or castle - inside and out.
Go to Home.Woot
Make it, build it, improve it. But whatever home project you've got in mind, start by saving money on it.
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Sports, fitness, and outdoors deals, because saving money is only one of your passions.
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You don't have to spend a lot to look like you do. Werk it and twerk it with amazing deals on designer watches, handbags and more.
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Deals for moms and dads and anybody else who needs kids' stuff, from toys to baby gear to furniture to clothing.
Go to Kids.Woot
Our exclusive graphic tees will make you laugh, will make you cry, will make you look totally hot.
Go to Shirt.Woot
Direct from the winery to your thirsty lips: wine deals worth doing a spit-take over.
Go to Wine.Woot
Last chance deals for hardcore cheapskates. Catch 'em before they - you guessed it - sell out.
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460,641 deals (and counting) from around the web, shared and ranked by a community of deal fiends like you. Go to Deals.Woot.
rdgeorge wrote:I've posted very little on these Woot discussions. (I've been primarily a silent and satisfied buyer -- with over 250 Woot orders so far.) However, I'm happy to answer your question about alternative sites. In addition to my Woot purchases, I have purchased from the following online stores, which all have excellent daily deal bargains. Sites with free shipping on all items: 1SaleADay, DailySteals, IceMonkey, BensOutlet. Sites on which many items are shipped for free: Tanga, GraveyardMall, NothingButSoftware. I've been a Woot customer since January 2008, but my patronage has now screeched to a halt with the new shipping charges. While I totally love the monkeys and the funny item descriptions, I hate Woot's sudden "in your face" multiple shipping charges (ostensibly required to provide us with a "wonderful new shopping cart")! Unless there's a change very soon at Woot (both in policy and attitude), I won't be back. Additionally, an apology to all previously loyal Wooters sure wouldn't hurt. Over the past year JCPenney customers became dissatisfied, just like multitudes at Woot who have voiced their opinions. JCPenney customers spoke up by shopping elsewhere. I certainly understand why. When a company unwisely disregards and disrespects its customers, it should fully expect to experience the dire consequences of its actions.
Exactly and thank you for the alternative sites.
jmalone wrote:Agreed, most of my buys here woot-off or not are impulse buys, and this will almost certainly cost me more or result in me buying less. I often jump on something I see early in the morning that I think will likely sell out, then return later in the day when i have time to check out Woot! Plus sales only because I have unlocked free shipping. While Woot! considers their Woot!-Off prices 'crazy-low' enough to still be a deal, which I feel is debatable, I can't even count the number of times I have seen loyal Wooters use the "Sure Woot! is only $2 cheaper than someone else on the internet, but I already unlocked free shipping" to justify a purchase at more post-mothership takover (less classic Woot! crazy low) high prices.
I agree, I am more likely to buy a second, third, fourth item if Ive already paid the $5 shipping anyway. It made me feel like I was getting an awesome deal with the rest of the items being "free shipping".
[b][u]won't[b][u] be wooting the same without unlock free shipping...one of the biggest incentives for me to buy from this site.
Well, this is disappointing. You guys don't realize how much the $5 all-day affected our buying habits. I don't have the time every day to dig through the entire woot lineup in one sitting. And given that the best deals get sold out quickly, the all-day thing worked well to get me to come back when I had a moment or two. The impetus for my impulse buying took a huge hit. I bought my second item today without really paying attention because the change wasn't made clear (confession: I don't read this blog every day.) When I went to add a third item and it came up with another $5 shipping, I promptly cancelled and checked to see what was up. I'd love to see some stats on whether the cart boosts sales or not. I realize that even with greater sales, the economics of the ship all day might balance. But I would be interested in the answer--are you making more money with or without the cart vs. all-you-can-ship?
Here is a real world example of how the new cart prevented me from buying something. I was going to buy some Pyrex No Leak containers, then I figured I might as well get a second different set since I had to pay for each set if I ordered the second later. I waited a day or two to see of there was anything else that showed up that I wanted. That gave me time to consider if I really need them and then during that time one of the items when out of stock, now I am not buying anything because I talked myself out of it and the price of one set with shipping isn't that much cheaper than what it is at Amazon with Prime. I guarantee I would have bought one, probably both, with the old system. Is that what you had in mind with the new shopping policy?
Not to burst any bubbles, but if you're thinking about buying something and wait on it and it sells out, Woot's attitude probably isn't "what a bummer that you missed it." It's probably more like "hey, we sold them all."
It's fun to browse all the stuff in all the assorted micro sites but Woot jumped the shark when instead of having one hopefully cool item per day it became just another site selling largely lots of junk and leftovers.
I've been a Wooter since 2004. Personally, I think that it's been going downhill since Amazon bought it, but this is the last straw. No more woot-offs for me! I'm even considering returning the woot-off flashing orange lights that I bought a few years ago!
rdgeorge wrote:Sites with free shipping on all items: 1SaleADay, DailySteals, IceMonkey, BensOutlet. Sites on which many items are shipped for free: Tanga, GraveyardMall, NothingButSoftware. ... While I totally love the monkeys and the funny item descriptions, I hate Woot's sudden "in your face" multiple shipping charges (ostensibly required to provide us with a "wonderful new shopping cart")! ... Additionally, an apology to all previously loyal Wooters sure wouldn't hurt.
Sadly, I'm still a little sore with some of the stores you've mentioned for tying up my order for weeks. There has to be something said about the ruthless speed and efficiency of Amaz-oot. That said, finding random stuff from SlickDeals, Cheapskate blog, or even Woot Deals is always helpful.
BS! You're going backwards, go forwards and honor Prime!
Every day woot feels more like Amazon but only more cluttered and disorganized. Woot has become a mega store of cast-off items. It's been 6 months since my last purchase and I don't see another one anytime soon. In the same period, I have bought 169 items in 87 orders at Amazon and I have Prime. Prime doesn't make the sale, the price of the item does but I find prices at or below woot directly from Amazon and my stuff is here in 2 days like clockwork. That's my $5 worth.....
I used to but 10 - 15 items in a Woot-Off. Having to pay $50 - $75 for shipping is not an option so I don't even watch them anymore. Damn sellouts! Remember no tax also, back in the day when Woot were men and sheep were nervous?!
Hi, Woot staff. I've had a few problems with Woot in the past, but have kept coming back because you've always made it worth my while. I will agree with many others that since Amazon bought Woot, the true "deals" are few and far between. The $5/day shipping did help compensate for that, as it gave one of the perks of dealing with a mega-corporation (cheap shipping!) to compensate for the reduction in frequency of excellent deals. As it is now, we have more expensive shipping combined with the disadvantage of getting less value from purchases. You can't have it both ways and retain your customers long-term. Either give us the perks of dealing with Amazon (use of Prime shipping, free shipping on purchases of $25 or more, etc.), or Amazon should allow Woot to operate as a completely independent entity in all but ownership. The latter seems a bit farfetched, since Woot packing slips are Amazon packing slips without the logo. Bet Amazon wanted to "streamline" shipping. Anyway, sorry you folks got bought out by Amazon. Really - it must not be any picnic, and you get to bear the brunt of customer wrath that should be directed at your corporate Master Control Programs.
I am HIGHLY pissed at the lack of a 5 dollar a day shipping cost for multiple items. Suck it woot, Ive been around a long time and stuck with yall through amazon and all the crappy products. You are losing a customer. I want to refund my 2 purchases I did today and cancel them but I just dont even want to deal with your staff which obviously doesnt value customer support.
Vote for a "Save for Later" option. Added something in my cart as a maybe. Removed it when I went to buy a shirt. Won't be adding it back as long as there's a Shirt.Woot-Off and will probably forget about it once it's over. :/
wondernerd wrote:If woot wants to consolidate shipping great, I like less boxes on my porch. So we the customers are helping woot cut cost and we are paying more for it.
editorkid wrote:Not to burst any bubbles, but if you're thinking about buying something and wait on it and it sells out, Woot's attitude probably isn't "what a bummer that you missed it." It's probably more like "hey, we sold them all."
If so, indeed a short-sighted perspective. In 6 months, the attitude might be, "I wish we knew why our woot-off sales have dropped so much..."
I must be late to the party. $5 shipping for every order? Goodbye impulse buying, now I will have to look through the whole site and decide during my visit what to buy. Probably not going to happen. Good luck with the shopping cart thing. P.S. I don't see too many WootOffs in my future 'cuz every item is gonna cost 5 bucks more. No time for lookin!
The cart is nice because you don't have to check out several times - but paying for shipping several times? NOT cool. Looks like my impulsive wooting is OVER! Turns a good deal into a not-so-good deal. How about keep the cart AND the $5 per day shipping? THAT would be a good deal. Really, this cart just ends up being a money maker for them. If they could ship it all for $5 a day before, there's no reason they can't now.
I'm not sure why they don't just do the $5 all day shipping for Woot-Offs, and take it off once the Woot-Off is over. I'm on the haven't-really-bought-anything-during-a-woot-off-due-to-lack-of-all-day-shipping bandwagon.
ThunderThighs wrote:Correct. The only midnight deadline now is the sale ending. Once the sale ends, you can no longer buy it, even if it's in your cart. Important thing to remember is that the item is not reserved for you. It's only yours when we get our money - when you've completed the transaction. As far as the woot-off, we know this is a change. The $5 all day shipping was always stated to be a temporary thing. We did that to make up for the fact that we didn't have a cart. You could shop the Plus events first and have them in your cart while shopping the woot-off. Then buy when you find something you want. Just watch that the items in the Plus event don't go out of stock if you have your heart set on them. The other advantage now is that you should see fewer boxes when ordering multiple items (if they'll fit in the same box and they're coming from the same warehouse).
My husband and I have made multiple orders since the cart was introduced. We started with woot before the $5 all you can ship, so it wasn't that big of a deal to us to see the change. In fact, the cart was actually an improvement over the original (?) model because we could have multiple items from multiple sites under one shipping charge, not $5 per item. Except, I have one complaint. Why do I seem to get tracking orders for every single item and boxes, sometimes comically large ones, for each item ordered? Never mind that I can't tell what is being shipped with each tracking number, but I thought this was supposed to result in fewer boxes? I guess we must be ordering from separate warehouses (the 3 sets of pjs we ordered for kids, from the same side sale, did arrive in just one box), but it is starting to get a little overwhelming.
CART = good $5 SHIPPING on every order = RIDICULOUS I haven't been on here in a bit, but now, after mistakenly making two separate orders in under 10 minutes and having to pay $10 shipping, I'm pretty annoyed. Woot's selection and prices aren't that much better than other online retailers to justify this, especially during Woot-offs. Guess my money will be going to Amazon and others again. If shipping costs are too much for Woot, how about an account option to HOLD all orders for a 24 hour period and ship them together? I don't have any need for my 8am Woot-off to ship immediately if I might want to add something additional at noon.
Yeah, I'm bummed. I bought 3 different items within 10 minutes, the first something I wanted, the other 2 were "what the heck, Christmas is coming". A fourth was in the cart before I noticed the $5 EACH shipping. I think some sort of rebate is in order for frequent, long term buyers. Kinda not worth spending $9.99 on a ball if there's five bucks shipping.
Yeah I just made a purchace for $50 on an item I thought would sell out quickly. I then wanted to look around to see what other deals they had to offer. I added another 150 or so to my cart and remembered the $5 for shipping change. I mean granted $5 is not a lot of money, but if it was still 5 all day Woot would have another $150 from me. I emptied my cart and I am posting this. I think that change is put a nail in my coffin for Woot. I'll be a 1 item woot buyer here on out.
once I woot something, I almost always spend the next 24 hours poking around for something else to buy since I now have free shipping. This is especially true for smaller items. Obviously now that won't happen. This will result in less purchases from me, both primary and ancilliary. Please consider bringing the all day shipping back... it's a woot distinctive. I'll come back then 91 woots and a woot fan from when woot was woot.
nemo74 wrote:Yeah I just made a purchace for $50 on an item I thought would sell out quickly. I then wanted to look around to see what other deals they had to offer. I added another 150 or so to my cart and remembered the $5 for shipping change. I mean granted $5 is not a lot of money, but if it was still 5 all day Woot would have another $150 from me. I emptied my cart and I am posting this. I think that change is put a nail in my coffin for Woot. I'll be a 1 item woot buyer here on out.
So you bailed on the purchase of $150 worth of items for a $5 shipping charge? That seems pretty impetuous...
Does this mean it is easier to get the Badgers or Chipmunks now? And during this current woot off how do we get the Badgers or Chipmunks?
As someone who has been using woot since 06 this came as something of a surprise to me. Granted I don't buy a whole lot of woots when I did it was usually during a wootoff and the all day shipping usually kept me looking all day. Had a lot to do with mentality of a shopper I think. What bothers me is that reading back on this old post is that they tried to pass this off as a good thing. I am the buyer you are the seller I understand that relationship, pricing changes happen but please don't try and put a spin on it. It just comes across as deceptive marketing. I know that woot wasn't taking the hit on all day shipping just because they couldn't figure out how to implement a shopping cart.
should be an all day shipping during a woot off. just throw a number out there if 5 is not enough for you guys.
What a load of crap with the 5 dollar shipping thing.
I just learned about this the hard way. After an initial Woot-off purchase, I impulsively purchased a second fairly inexpensive item on the same day thinking "What the heck, no shipping charge". That won't happen again.
tgrebe wrote:I just learned about this the hard way. After an initial Woot-off purchase, I impulsively purchased a second fairly inexpensive item on the same day thinking "What the heck, no shipping charge". That won't happen again.
Which Team Fumbles? - I just learned the hard way too -- what a stupid change. This is the lest Woot Off Ill be babysitting. You really should revisit this decision Woot.
HATE IT - bought four item during the WOOT OFF and was charged $20 for shipping. Looks like my WOOT days are over.
It would be acceptable if the all day $5 shipping were available to Amazon Prime subscribers.
I just realized that this was happening. I was about to buy my 3rd woot off item and boom... no free shipping. I didn't notice it on the second. Time to close the browser and back away. I think that is crazy that they are charging shipping on each item during a woot off where you can't hold it in your cart.
chanandbritt wrote:HATE IT - bought four item during the WOOT OFF and was charged $20 for shipping. Looks like my WOOT days are over.
BIGELLOW wrote:It would be acceptable if the all day $5 shipping were available to Amazon Prime subscribers.
Should be FREE for Amazon Prime subscribers!!!
Stop it, compromise not allowed here. FWIW I like this idea
Ambix wrote:As someone who has been using woot since 06 this came as something of a surprise to me. Granted I don't buy a whole lot of woots when I did it was usually during a wootoff and the all day shipping usually kept me looking all day. ...
Whoa there, friend. You've been here since '06 and you think it used to always be $5 all day shipping? I joined in '09 and it was $5 shipping PER WOOT up until like 2012 or something. Then it was "for a limited time only" $5 all day shipping because they added so much crap to the site. In less than a year (I think), they got the shopping cart implemented and it became $5 per order. Did you just start following woot-offs in 2012?
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subset: commoncrawl


text:
Posch pleads to charges
Joshua Sebold
Staff Writer
High Desert State Prison Sergeant Todd Posch pled no contest to two counts of filing a false police report Tuesday, April 27.
Each charge carries a maximum possible jail sentence of six months for a total exposure of one year. Sentencing is scheduled for June 7.
Posch's plea may also leave him vulnerable to restitution claims.Posch fabricated two incidents where he reported being assaulted by "Mexican gang members."
The Plumas County Sheriff's Office previously reported more than $100,000 in state and local funds was expended for investigative and security efforts resulting from Posch's false reports.
Sheriff Greg Hagwood has made it clear he expects full restitution from the defendant for expenses incurred by his department.


text:
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Flat-topped, four-hole black Corozo tagua nut button, with an engraved fouled anchor motif. This is the traditional pea coat button, but made of lustrous high-end Corozo tagua nut.Sizes: 7/8", 1", 1 1/8"$3.95 -
Black Chef's Coat Stud Plastic Button
A black removable plastic stud button for a professional chef's coat. The backing is flat and 11/16", and the ball top is 1/2".$1.95 -
3/8" Black & Rhinestone Tuxedo Shirt Stud (Made in Spain)
3/8" steel metal tuxedo shirt stud, with a clear rhinestone set into an elegant black enameled top. Back measures 1/2". Made in Spain$6.95 -
3/8" Black Enameled Tuxedo Shirt Stud (Made in Spain)
3/8" steel metal tuxedo shirt stud, with an elegant black enameled top. Back measures 1/2". Made in Spain$3.95


text: Grilling meat is easier—and safer—than ever when you use this double-layered set of trays made of lightweight melamine. Place your raw meat on the red tray, position the black tray underneath and carry both trays to the grill. While the meat is cooking, switch the trays so the black one is on top—ready to hold your cooked meat. The nested design safely prevents cross-contamination between uncooked and cooked food.


text:
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Home > Health & Fitness > Healthwise > Skin Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI]
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.
Note: Separate PDQ summaries on Skin Cancer Screening, Skin Cancer Treatment, and Levels of Evidence for Cancer Screening and Prevention Studies are also available.
Individuals whose skin freckles, tans poorly, or burns easily after sun exposure are particularly susceptible to developing skin cancer.[1] Observational and analytic epidemiologic studies have consistently shown that increased cumulative sun exposure is a risk factor for nonmelanoma skin cancer.[1,2] Organ transplant recipients receiving immunosuppressive drugs are at an elevated risk of skin cancer, particularly squamous cell carcinoma (SCC). Arsenic exposure also increases the risk of cutaneous SCC.[3,4] In the case of melanoma, it seems that intermittent acute sun exposure leading to sunburn is more important than cumulative sun exposure;[5] such exposures during childhood or adolescence may be particularly important.[6] Nonmodifiable host factors, such as a large number of benign melanocytic nevi and atypical nevi may also increase the risk of developing cutaneous melanoma.[6]
Factors Associated With an Increased Risk of Nonmelanoma Skin Cancer
Sun and ultraviolet (UV) radiation exposure
Based on solid evidence, sun and UV radiation exposure are associated with an increased risk of SCC and basal cell carcinoma (BCC).
Magnitude of Effect: Substantial, depending upon amount of exposure.
Factors Associated With an Increased Risk of Melanoma
Sun and UV radiation exposure
Based on fair evidence, intermittent acute sun exposure leading to sunburn is associated with an increased risk of melanoma.
Magnitude of Effect: Unknown.
Sunscreen Use and Ultraviolet (UV) Radiation Avoidance
The evidence that interventions designed to reduce exposure to UV radiation by the use of sunscreen, protective clothing, or limitation of sun exposure time decrease the incidence of nonmelanoma skin cancer is inadequate. A randomized study suggested a possible reduction in incidence of squamous cell carcinomas (SCCs), but study design and analysis problems complicate interpretation of the results.[1,2]
Magnitude of Benefit: Not applicable (N/A) (inadequate evidence).
The harms of sunscreen use are poorly quantified but are likely to be small, including allergic reactions to skin creams and lower production of vitamin D by the skin with less sun exposure.
It is possible that individuals who use sunscreen may experience excess sun exposure because they avoid sunburn but do not avoid harmful UV radiation.
Chemopreventive Agents
There is inadequate evidence to determine whether the use of chemopreventive agents reduces the incidence of SCC or BCC of the skin.
Magnitude of Effect: N/A (inadequate evidence).
Beta carotene use has been associated in RCTs with an increased risk of lung cancer incidence and mortality in smokers. Isotretinoin has dose-related skin toxicity. COX-2 inhibitors, such as celecoxib, have been associated with cardiac toxic effects in RCTs for the prevention of colorectal cancer.
There is inadequate evidence to determine whether the avoidance of sunburns or the use of sunscreen alters the incidence of cutaneous melanoma.
Magnitude of Benefit: Unknown.
Incidence and mortality
There are three main types of skin cancer:
BCC and SCC are the most common forms of skin cancer but have substantially better prognoses than the less common, generally more aggressive, melanoma.
NMSC is the most commonly occurring cancer in the United States. Its incidence appears to be increasing in some,[1] but not all,[2] areas of the country. Overall U.S. incidence rates have likely been increasing for a number of years.[3] At least some of this increase may be attributable to increasing skin cancer awareness and resulting increasing investigation and biopsy of skin lesions. The total number and incidence rate of NMSCs cannot be estimated precisely because reporting to cancer registries is not required. However, based on extrapolation of Medicare fee-for-service data to the U.S. population, it has been estimated that the total number of persons treated for NMSCs in 2006 was about 3,500,000.[3,4] That number exceeds all other cases of cancer estimated by the American Cancer Society for that year, which totaled about 1.4 million.[5]
Melanoma is a reportable cancer in U.S. cancer registries, so there are more reliable estimates of incidence than is the case with NMSCs. In 2014, it is estimated that 76,000 individuals in the United States will be diagnosed with melanoma and approximately 9,710 will die of the disease.[4]
The incidence of melanoma has been increasing for at least 30 years.[4]
Risk Factors
Epidemiologic evidence suggests that exposure to ultraviolet (UV) radiation and the sensitivity of an individual's skin to UV radiation are risk factors for skin cancer, though the type of exposure (high-intensity and short-duration vs. chronic exposure) and the pattern of exposure (continuous vs. intermittent) may differ among the three main skin cancer types.[6,7,8] In addition, the immune system may play a role in pathogenesis of skin cancer. Organ transplant recipients receiving immunosuppressive drugs are at an elevated risk of skin cancer, particularly SCC. Arsenic exposure also increases the risk of cutaneous SCC.[9,10]
The visible evidence of susceptibility to skin cancer (skin type and precancerous lesions), of sun-induced skin damage (sunburn and solar keratoses), and the ability of an individual to modify sun exposure provide the basis for implementation of programs for the primary prevention of skin cancer.
Factors associated with increased risk of nonmelanoma skin cancer
UV radiation exposure
Most evidence about UV radiation exposure and the prevention of skin cancer comes from observational and analytic epidemiologic studies. Such studies have consistently shown that increased cumulative sun exposure is a risk factor for NMSC.[7,8] Individuals whose skin tans poorly or burns easily after sun exposure are particularly susceptible.[7]
Factors associated with an increased risk of melanoma
The relationship between UV radiation exposure and cutaneous melanoma is less clear than the relationship between UV exposure and NMSC. In the case of melanoma, it seems that intermittent acute sun exposure leading to sunburn is more important than cumulative sun exposure;[11] such exposures during childhood or adolescence may be particularly important.[6]
Interventions With Inadequate Evidence as to Whether They Reduce Risk of Nonmelanoma Skin Cancer
Sunscreen use and UV radiation avoidance
It is not known whether interventions designed to reduce exposure to UV radiation through the use of sunscreens and protective clothing or through limitation of exposure time reduce the incidence of NMSC in humans. Some studies have used solar keratoses rather than invasive skin cancer as the study endpoint. It is generally felt that half or more of SCCs arise from solar keratoses. However, nearly half of SCCs occur in clinically normal skin.[12] A longitudinal study has shown that the progression rate from solar keratoses to SCC is about 0.075% to 0.096% per year, or less than 1 in 1,000 per year.[12] Moreover, in a population-based longitudinal study, there was an approximately 26% spontaneous regression rate of solar keratoses within 1 year of a screening examination.[13] Therefore, it is likely that solar keratosis is a poor surrogate endpoint in SCC prevention trials.
One very small randomized placebo-controlled study of a sunscreen (sun protection factor [SPF] 29) was conducted in 53 volunteers who had either clinical evidence of solar keratoses or NMSC.[14] Only 37 of the participants returned for the planned 2-year follow-up (attrition rate of 30%). The rate of new solar keratoses was lower after 2 years in the sunscreen group than in the placebo (base-cream) group (estimated 36% reduction in annual rate, P = .001). Another study showed that regular sunscreen use helps reduce the incidence of solar keratoses and increase remission of existing lesions.[15] In Australia, 588 persons aged 40 years and older who attended a free skin-cancer screening clinic and had 1 to 30 solar keratoses were enrolled in a randomized controlled trial (RCT) assessing the effect of regular sunscreen (SPF 17) use on solar keratoses; 431 persons completed the study. Individuals in the sunscreen group developed fewer new lesions and had more remissions of existing lesions than those in the base-cream placebo group. There was an increase of 1.0 in the mean number of solar keratoses in the base-cream group versus a decrease of 0.6 in the sunscreen group (difference = 1.53; 95% confidence interval [CI], 0.81–2.25). The rate ratio of new lesions was 0.62 (95% CI, 0.54–0.71). Furthermore, in the sunscreen group, the development of new lesions and the remission of existing lesions were related to the amount of sunscreen used. Such a relationship was not observed in the base-cream group.
However, a different Australian randomized study (the Nambour Skin Cancer Prevention Trial) showed that, after 4.5 years of follow-up, there was no statistically significant difference in the incidence of BCCs or SCCs with regular SPF 16 sunscreen use. This study did not include a sunscreen placebo. Although a secondary subset analysis of the overall number of tumors showed a reduction in the frequency of SCCs on the sites of daily sunscreen application, the validity of the finding is questionable because of the possible effects of extensive multiple statistical testing.[16] An 8-year post-trial observational follow-up demonstrated statistically significant reductions in both the frequency and the overall incidence of SCCs in the regular sunscreen-use arm, but the reliability of these findings is uncertain given their occurrence outside of the controlled-trial environment.[17]
Chemopreventive agents
Beta carotene
In the Physicians' Health Study, 21,884 male physicians with no reported history of BCC or SCC were randomly assigned to take 50 mg doses of daily oral beta carotene versus placebo in a 2 × 2 factorial trial of beta carotene and aspirin.[18] Incidence of NMSCs was a secondary endpoint in the trial. After 12 years of beta carotene or placebo administration, there was no difference in incidence of either BCC or SCC. RCTs of long-term treatment with beta carotene in individuals previously treated for NMSC also showed no benefit in preventing the occurrence of new NMSCs.[16,19]
High-dose isotretinoin was found to prevent new skin cancers in individuals with xeroderma pigmentosum.[20] However, a RCT of long-term treatment with isotretinoin in individuals previously treated for BCC showed that this agent did not prevent the occurrence of new BCCs but did produce side effects characteristic of isotretinoin treatment.[21,22]
A multicenter, double-blind, randomized, placebo-controlled trial of 1,312 patients with a history of BCC or SCC and a mean follow-up of 6.4 years showed that 200 µg of selenium (in brewer's yeast tablets) did not have a statistically significant effect on the primary endpoint of BCC development and may increase the risk of SCC and total NMSC.[23,24] The cumulative incidence of NMSC was 0.20 versus 0.16 per person year of follow-up in the selenium and placebo groups, respectively (unadjusted relative risk = 1.27; 95% CI, 1.11–1.45).
The use of celecoxib as a chemopreventive agent for actinic keratosis was assessed in a double-blind, randomized, placebo-controlled trial. Two hundred forty high-risk men and women (each with 10–40 actinic keratoses and a history of previous skin cancer) received 200 mg doses of celecoxib twice daily or a placebo for 9 months with an additional 2-month follow-up. No difference was found in the incidence of actinic keratosis, but a post hoc analysis revealed a statistically significant difference in the mean number of NMSCs per patient (rate ratio, 0.43; 95% CI, 0.24–0.75; absolute difference, 0.2 lesions per patient). The ultimate utility of celecoxib in preventing NMSCs remains unclear, given the exploratory nature of the analysis, the challenge of interpreting benefits in fractions of lesions, and the potential for serious adverse cardiovascular effects associated with long-term use of nonsteroidal anti-inflammatory drugs. However, the unexpected finding of the lack of effect of celecoxib on actinic keratosis but apparent effect on SCC and BCC incidence raises questions about the use of actinic keratosis as an intermediate endpoint for SCC and BCC and the current understanding of the natural history of NMSCs.[25]
Alpha-difluoromethylornithine (DFMO), an ornithine decarboxylase inhibitor used in intravenous form to treat African trypanosomiasis and in topical form to treat female hirsutism, was investigated as a chemopreventive agent in patients with prior NMSCs.[26] After a 4-week placebo run-in period, 291 volunteers who took at least 80% of their placebos were randomly assigned to oral DFMO (500 mg/m2 /day) versus placebo for up to 5 years (average 4 years). At baseline, the placebo group had a higher mean number of prior NMSCs than the DFMO group (4.9 vs. 4.2; P = .1), and a longer history of NMSC (P = .002), possibly favoring the DFMO group. The primary endpoint of the study was the number of new NMSC events, and the rate was 0.44 new cancers per year in the DFMO group versus 0.61 in the placebo group (P = .07). In a subset analysis, there was a statistically significant difference in BCC events favoring the DFMO group (0.28 vs. 0.40 per year; P = .03) and no difference in SCC rates. DFMO is known to have ototoxicity, and the average hearing loss of audiograms was greater in the DFMO group, which was about 4 dB versus 2 dB (P = .003). In the DFMO group,10.8% discontinued the study drug because of a greater than 15 dB hearing loss, compared with a 4.5% discontinuation in the placebo group (P = .06). DFMO hearing loss is usually reversible. In summary, the efficacy of DFMO for skin cancer prevention is unclear, and it remains investigational for this indication.
Interventions With Inadequate Evidence as to Whether They Reduce Risk of Melanoma
Results from a collaborative European case-control study and one animal study suggest that sunscreens that protect against sunburn may not protect against UV radiation–associated cutaneous melanoma.[27,28] Nonmodifiable host factors, such as propensity to burn, a large number of benign melanocytic nevi, and atypical nevi may also increase the risk of developing cutaneous melanoma.[6]
A post hoc analysis of the Nambour Skin Cancer Prevention Trial (discussed above) examined the incidence of melanoma at a median of 14.2 person-years of follow-up. In the trial, participants were randomly assigned to daily or discretionary sunscreen use from 1992 to 1996. Follow-up continued until 2006 via either active participation, in which subjects completed periodic questionnaires about new skin cancers and relevant sun behaviors, or passive participation, in which subjects' medical records were reviewed for skin cancer diagnoses; 52% of the trial participants were actively participating as of 2006. Eleven melanomas were diagnosed in the daily sunscreen arm versus 22 in the discretionary-use arm (hazard ratio [HR] = 0.5; 95% CI, 0.24–1.02), of which 3 versus 11 were invasive, respectively (HR = 0.27; 95% CI, 0.08–0.97). There was no difference in the rates of melanoma on prescribed sunscreen application sites between the two groups. This study has several important limitations: melanoma was not a planned outcome of the original trial; the CIs of the outcome estimates are very wide, indicating substantial uncertainty of the magnitude of the effect; and there is potential for the introduction of confounding with the widespread use of the passive participant option during the follow-up phase of the study.[29]
A meta-analysis of 18 studies that explored the association between melanoma risk and previous sunscreen use illustrates widely differing study qualities and suggests little or no association.[30] A systematic review of the association between sunscreen use and the development of melanocytic nevi in children reported similar issues with study quality and heterogeneity, hindering conclusive assessments; however, of 15 studies meeting inclusion criteria, 12 found either an increased incidence or no association.[31] Thus, the current evidence indicates that sunscreen application as practiced in the general population shows no clear association with reduced risk of melanocytic nevi or melanoma.
Behavioral Interventions to Change Sun-Protective Practices
As noted previously, direct evidence that interventions, such as sunscreen or protection from UV light exposure, decrease the risk of skin cancer is sparse. However, given the association between UV light exposure and subsequent risk of skin cancer, counseling interventions aimed at increasing sun-protective behaviors have been examined. The U.S. Preventive Services Task Force (USPSTF) commissioned a systematic review of this evidence. Although the USPSTF review found no randomized trials directly linking counseling strategies to skin cancer reduction, it found 11 trials, rated as fair in quality, that tested the effect of interventions on sun-protective behaviors.[32] Several trials of behavioral interventions in adults, sometimes as part of an intervention addressing multiple health-related behaviors, such as smoking and nutrition, showed a short-term increase in self-reported sun-protective behaviors. However, the effect sizes were small to modest, without clear evidence that the differences were clinically meaningful.[33,34,35,36,37] Likewise, appearance-based behavioral interventions in young women have had a favorable impact on self-reported indoor tanning behavior, but no long-term follow-up or health outcomes were reported.[38,39,40] A randomized, primary care office–based counseling intervention in adolescents showed an increase in self-reported midday sun avoidance and sunscreen use in the intervention group for up to 24 months.[41] A randomized trial of a provider-based sun protection promotion counseling program for parents for their infant children showed a small increase in sun-protective actions, of questionable clinical importance according to the researchers.[42]
Nevertheless, studies of intervention strategies for reducing UV radiation exposure suggest that the best approach is education about the risks associated with sun exposure and sunburn and education about sun-protection strategies.[43,44] In one study, an educational intervention at the time of treatment for skin cancer—a time when an individual may have heightened awareness of his or her susceptibility to skin cancer—seemed to have the greatest effect.[43] However, even in such a high-risk group, it was difficult for many individuals to maintain sun-protective behaviors. In a community skin cancer screening study, researchers found that, although regular use of sunscreens was not related to personal or family history of skin cancer, it was more common among persons who perceived themselves to be at moderate or high risk of developing melanoma.[44]
Sun-protective strategies may include avoiding sun exposure at times of the day when the exposure is more intense and wearing clothing that protects skin from sun exposure. Self-examination for skin-pigmentary characteristics associated with melanoma (e.g., freckling status) may be a useful way to identify individuals at an increased risk of developing melanoma.[45] Skin type (propensity to burn after sun exposure and tanning ability), alone or with other physical characteristics, such as hair color, has been used as a measure of sun sensitivity in epidemiologic studies.[46]
In summary, a number of randomized trials and other studies have suggested that counseling or health information may have an effect on sun- or UV-protective behaviors. However, in addition to lack of information on health outcomes and relatively short follow-up times, most of the studies suffer from important methodologic problems, including the possibility of self-reporting inaccuracy, high study attrition rates, and lack of information about sustainability of the interventions.
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Description of the Evidence
Added American Cancer Society as reference 4.
Updated statistics with estimated new cases and deaths for 2014.
This summary is written and maintained by the PDQ Screening and Prevention Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.
If you have questions or comments about this summary, please send them to Cancer.gov through the Web site's Contact Form. We can respond only to email messages written in English.
Purpose of This Summary
This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about skin cancer prevention. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.
Reviewers and Updates
This summary is reviewed regularly and updated as necessary by the PDQ Screening and Prevention Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).
Board members review recently published articles each month to determine whether an article should:
Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary.
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Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Screening and Prevention Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations.
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The preferred citation for this PDQ summary is:
National Cancer Institute: PDQ® Skin Cancer Prevention. Bethesda, MD: National Cancer Institute. Date last modified <MM/DD/YYYY>. Available at: http://cancer.gov/cancertopics/pdq/prevention/skin/HealthProfessional. Accessed <MM/DD/YYYY>.
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Last Revised: 2014-02-27
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Jets sticking with Sanchez at QB
Sanchez pulled from last Sunday's game
UPDATED 9:27 PM PST Dec 05, 2012
Ryan said Monday he would take a day or two to discuss his options with staff before naming the starter for Sunday's game at Jacksonville.
Tim Tebow could be demoted to No. 3 spot on the depth chart with a lingering rib injury.
Sanchez is guaranteed $8.25 million in 2013.


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Complete Willies Diary
360°: 2011
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Vertigo: 2005/06
Vancouver GM Place I
28 April 2005
Vancouver GM Place I
There's currently much talk about basketball. The Chicago Bulls won last night in a series of the best of seven against the Washington Wizards. So what? comes the cry from the international rock community, but the interest in Vertigo-Land comes from more then just sports fever.We are about to play a week of dates in Chicago from May 7 - 12; there are four show days with two days off on the 8th and 11th. The shows are at the United Centre in Chicago, which is home of......the Chicago Bulls, so perhaps you can see where this is going.Rock tours in North America are booked around the availability of the sports facilities which make up a large portion of the venues. Those two "days off' in our schedule depend entirely on the United Centre not being used for basketball games. If suddenly the building is needed on those days then we could face a situation where we have to load in for the first show and load-out immediately afterwards, then load back in on the 9th for two shows and load-out the night of the 10th, then load back in on the morning of the 12th and out again after the show that same day. In short a very major drag, particularly as we were relying on the first day off to load in all the additional equipment required for the proposed Big Video Shoot on the 9th & 10th.It's widely known that I personally couldn't give a rat's ass about sporting events of any kind anywhere on this planet or any other. However, I can see the seriousness of this situation so have relied on the sporting knowledge of my colleagues to appraise me of the precise range of possible scenarios, which runs, I believe, as follows: If the Bulls win or lose on game six of this series, we won't have to load-out at all, which would be the ideal situation. If they win or lose in fewer than six games, we won't have to load-out after the first show (which at least prevents the video shoot from being plunged into crisis) but we will have to load-out after the third show because the second series games will begin sooner. In tandem with this, apparently we also have to care about what Miami are up to. If Miami goes the full seven games in this first series, it will push the start of the second series games back beyond our Chicago dates, meaning that we are homefree for the days off.
To cut to the chase, we're looking for a Bulls victory on precisely game six to keep the venue free and have our audience be happy with a local win, so I call upon the collective karma of the entire U2.Com community to send out positive vibes for this result. Those really keen on assisting us, can find the full game schedule at ChicagoBulls.com. Naturally we'll be keeping you posted on Chicago Day Off Developments as they unfold.
Meanwhile, back in the present, I spent my morning answering a flock of e.mail which had gathered in my in tray whilst I slept. It gave me a fairly typical selection of tasks to deal with, European show, Chicago video shoot, pending guests lists, etc.
Into the gig at 1pm where I was promptly dragged into a meeting withproduction manager Jake Berry to sort out the design of the carts for the followspot gallery for the outdoor show (try to stay awake here), then into the arena itself to carry on with the video shoot for 'City of Blinding Lights'. We spent three or four more hours doing run-throughs primarily for close ups, and all seemed to go well. It looked great on my little monitor at the mix position.
I spend some time pulling stills from my surveillance movies to send to Wired magazine, had my tea, then finally, to round off the day, did a big rock show.
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He-Man Shirts
For all of you He-Man (and Star Trek) fans out there, did you know that the He-Man episode, "The Arena," was based on the Star Trek episode of the same name? Yeeup! In the Star Trek episode Kirk is forced by some uber-powerful beings to battle the opposing Gorn captain unarmed. In the He-Man episode, an immensely powerful, yet peaceful...View More


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Hypothermia is dangerously low body temperature, below 95 °F (35 °C).
Low body temperature; Cold exposure
Persons most likely to experience hypothermia include those who are:
Hypothermia occurs when more heat is lost than the body can generate. It is usually caused by extended exposure to the cold.
Common causes include:
As people develop hypothermia, they slowly lose the ability to think and move. In fact, they may even be unaware that they need emergency treatment. Someone with hypothermia also is likely to have frostbite.
The symptoms include:
Lethargy, cardiac arrest, shock, and coma can set in without prompt treatment. Hypothermia can be fatal.
Call 911 anytime you suspect someone has hypothermia. Give first aid while awaiting emergency assistance.
Before you spend time outside in the cold, do NOT drink alcohol or smoke. Drink plenty of fluids and get adequate food and rest.
Wear proper clothing in cold temperatures to protect your body. These include:
If you have diabetes or circulatory problems, see your doctor regularly and maintain good health habits in order to reduce the risk of blood vessel complications that may put you at risk for hypothermia.
Danzl DF. Accidental hypothermia. In: Marx JA, Hockberger RS, Walls RM, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 7th ed. St. Louis, MO: Mosby; 2009:chap 138.
Bessen HA. Hypothermia. In: Tintinalli JE, Kelen GD, Stapczynski JS, Ma OJ, Cline DM, eds. Emergency Medicine: A Comprehensive Study Guide. 6th ed. New York, NY: McGraw-Hill; 2004:chap 192.
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no1 wrote:Mr. Kneny, Could be. Mabe not. I guess I'm waffling a little.
I talk around the sticky issue as well.
SkekTek wrote:Yeah, no streak anymore. Gonna start a new one?
well, seeing on how it ended by accident.. I must.
kenney9226 wrote:I talk around the sticky issue as well.
You can always get them with the sticky in the center...
SkekTek wrote:You can always get them with the sticky in the center...
I like them slathered in butter!
no1 wrote:Prof. Tek, Yes, I'd like to see Mr. Kneny streaking. ...or mabe not.
I got a good idea for the alphabetical pucker. might take ten minutes to make!
no1 wrote:Mr. Kneny, Maple you should try buttering up the boss.
he gets burnt under the heat lamps. HA! I got the last psot!
no1 wrote:What?
no1 wrote:Mr. Kneny, What's last post?
It's the last piece of mail you'll ever get. last parcel post.
no1 wrote:last yammer, Mr. Kneny.
right. sorry. last ymamer.
no1 wrote:Did Ms. Name really leave?
Prof. Tek was here as well and left. And Gman too before we hijacked his thread...
no1 wrote:Mr. Kneny, Advice: Don't greet your friend John on an airplane with "Hi, Jack!"
thanks. There's a guy named Steve Martin who works in my building.
kenney9226 wrote:thanks. There's a guy named Steve Martin who works in my building.
And a John Holmes!
kenney9226 wrote:And a John Holmes!
And...... Ellis Cooper!
My old doctor's name was John Holmes. I didn't understand why people laughed at that until I was a little older. Edit: Is it can be last post?
no1 wrote:Mr. Kneny, I guess that's better than having a girl named Steve Martin working in your building.
yes. page 101 last yammer!
Poor Gman. Driven out of his own thread.
selli wrote:Poor Gman. Driven out of his own thread.
sad people like me. edit: FOURTH FROM LAST POST!!! good job No1!! poster note, what happened that I, the runner-up, got this last post? Was Mr. No1 unable to perform his last poster duties? Was there a scandal of some sort? Mod note, I can't believe No1 backed out of his last post. You still have it Mr1. What a p i a.
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This is the patented pogo stick that bounces riders up to four feet in the air. Unlike typical pogo sticks that use coiled steel springs, this model propels riders with a bow-shaped spring made of composite fiber. This mechanism much more efficiently returns the downward force, enabling bouncers to achieve extreme heights. The shaft of the pogo stick is constructed of lightweight yet rugged high-grade aluminum. Padded handlebars and aluminum footrests provide comfort and stability during use. For riders 120 lbs. to 154 lbs. Helmet and pads should be worn at all times (not included). Ages 13 and up. 38" H x 15" W x 6" D. (9 lbs.)
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Scientific American at the World Economic Forum in Davos [Video]
February 9th, 2014 | 1
Since 1845, Scientific American has covered the innovations that sit at the nexus of science, business and policy. In its early years, as the Industrial Revolution swept across the U.S., our pages were rife with the focus and expectation that human's inventiveness would ease humankind's labors and improve the world. Today, with a global population [...]
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Through November 15th, Living Social has a $20 Overstock.com credit for $10. Limit one per person; promotional value expires 2/11/13. Excludes shipping costs.
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