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Top 12 Banned Dog Breeds
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I have two Rotties and they are very loyal and seek to please their owners. Intelligent and obedient and affectionate and once introduced and get used to a visitor they would be living to them as well. There aren't bad dogs, just bad owners. Dogs need training. Bad owners don't either train at all or they train badly.
January 24 2015 at 3:17 AM Report abuse Permalink rate up rate down ReplyOh my god.. that "article" about czechoslovakian wolfdog is almost completely wrong...
Yes they are quick and energetic, thats only thing correct
They are not fearless, they are cautious but almost zealous when it comes to protecting the pack (owner, its family and yes, even the children)
their prey drive is same as DSG but NO WAY THEY ARE EXTREMELY UNPREDICTABLE!!! FFS this breed originates as Military SpecOps and Border guard corps workdog... unpredictability was the exact thing military eradicated. They are perfectly trainable. It takes them longer time tha DSG, because they are extremely intelligent and they just dont see any point in repeating the same excersise dozen times over and over.
They actually make perfect household pets. They are happy with their pack and so with proper walks, they are perfectly fine with living in a flat. Actually they are only shepherd breed which can live in a flat without problems.
And finally.. they are perfect dog to be with children. Of course, you cant leave them alone (but that counts for ALL dog breeds) but they consider them to be part of the pack... What better thing you can imagine to protect your children than wolfdog on his guard?
And to debra, you are obviously unaware of the difference between the attack of a pittbull and the attack of a labrador, look it up because that is the reason why you dont hear about a labrador attack on the news and the very reason why a dog on the list is classified as such. All the posts below i have read are by very ignorant, not very intelligent people. Just the type of person who should not be allowed to own a dangerous breed dog!
April 24 2014 at 10:57 PM Report abuse Permalink rate up rate down ReplyJudging by most of these posts its not surprising there are fatalities from dog attacks with so many ignorant dog owners. Fyi a lot of attacks are from dogs to family members who have known the dogs for a long time then suddenly one day the dog snaps. To all you people above who say you are perfectly fine with your kids rolling around with your pitt bulls, you sound as if you would be fine for your kids friends to come into your home and do the same. Your defensive attitudes make you just the sort of owners who shouldn't own big dangerous breeds. Responsible dog owners are always cautious of how their dog may behave with children or other dogs, irresponsible ones are not. The fact you assume your dog is a gentle misunderstood victim of misguided views makes you and your dominant breed dog a danger to everyone, a responsible dog owner would never assume such a thing.
April 24 2014 at 10:51 PM Report abuse Permalink +1 rate up rate down ReplyI agree on the way the puppy is brought up.How they train it also.But if the parents of the puppy
is aggressive them the puppy will be like that.It is ture in the genes of the dog.
I have three but I full huge dogs and my biggest one is an American bull and he climbs in bed with me under the covers he nozzles me when I'm hurt or upset he loves my children he lays in bed with me he is basically my best friend if anyone tried to take him the only dangerous thing they need to worry about is me a dog is like a child with a mum they learn from us and if we love them they will love us unconditionaly forever ...Thanks for listening to me we must stand for them no one else will
March 25 2014 at 8:54 AM Report abuse Permalink +1 rate up rate down Replylist like these are plain ignorant I have a Doberman Pincher and he is the most affectionate goofy dog I have ever had the pleasure to know. I have two pit bulls as well and they both having personalities of their own are wonderful dogs. I find it ridiculous that all these so called agressive breeds are put on list like these. the so called agressive breeds end up being the most loyal and loving dogs. I love dobermans and pit bulls!!!
March 14 2014 at 1:53 PM Report abuse Permalink +1 rate up rate down ReplyI agree that dog bite data is very inaccurate and for that reason, so are these lists. It never makes the paper or the 6 o clock news when someone gets bit by a lab. A friend of mine was severely mauled by her friend's Labrador retriever, hospitalized, out of work for 6 months etc. never made the news or any newspapers. Can you imagine the hype if that had been a pit bull? I was bit by a dog as a child, by a cocker spaniel. My friends grandson got a bad bite to the face by the family dog, again not any of the breeds on these lists. My daughter was a dog groomer, bit multiple times by dogs, always the smaller ones. She fell in love with pit bulls after working with them beta sues they were so friendly and eager to please and never gave her any trouble. Dog bites are almost always caused by badly behaved humans, poorly trained dogs and misunderstandings between the two.
March 14 2014 at 12:06 AM Report abuse Permalink +1 rate up rate down Replybloodhounds seriously? How is it even fair to ban a dog based on size alone? So only small dogs deserve love and a chance to live? Sounds anti-humanism to me. Ridiculous.
March 13 2014 at 3:37 PM Report abuse Permalink rate up rate down ReplyOnly a genetically unstable dog is dangerous. It has nothing to do with with the breed, it's the individual dog.The breed as whole is NOT dangerous. Sure, there are dogs of that breed that are "dangerous", but in every breed, there IS a dangerous dog.
Heck, the Pit Bull breed is one of the most over-bred dogs. SO many breeders don't give two sh'ts. They create a problem. They breed dogs that have poor temperaments, dogs that are unstable. Back in the day when the breed was becoming a breed, a human aggressive dog would be culled. The only times a dog will be1. Human Aggressive is if the dog is Unstable, or unsound. 2. The dog was raised in unstable environment. The dog was abused,or neglect. Sometimes if a dog has very little, or no human contact the dog will be fear aggressive 3. Socialization. 4. The dog is the wrong hands
Some of these breeds are dog aggressive, genetically. Most(well all), are usually not dogs for the novice owner. There wonderful dogs don't get me wrong.But so many dogs end up in the wrong hands. The majority of pet owners can't properly own a DA dog. You can't take away DA, you can only control it. DA, is a trait, & lie any other trait, it is genetically wired.


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Texas Rangers Gear
Texas Rangers Ladies
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Product ID: 953165
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Only the best Texas girls know how to strut their stuff at a game. They wouldn't be caught dead in big, baggy T-shirts or old, worn-out tees. This Nike Cooperstown Collection Deep V tee was made with those Texas girls in mind. A retro Rangers team name and logo is printed across the chest and the deep V-neck gives your look a sassy edge. The tri-blend fabric and slim fit style of this comfy tee will keep you looking sharp while you're watching the Rangers win yet another home game!
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Customized items can be personalized with options such as your name, your favorite
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Photos by Michael S. Fischer (1989-2012)
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Michael Storm Fischer was the longest-serving student photographer in Pennsylvania College of Technology's College Information and Community Relations Office when he died in August 2012 at the age of 23. With a skilled eye, he captured campus and community moments that ranged from celebratory to serene.


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3) RealSPEED Connection Speed-Up Utility 3.1 RealSPEED is a program empowering and speed up your internet connection sharply. It is optimizing the unknown settings and the registry of your operating system. Supports most of the connection types like Modem, Cable, ISDN, xDSL, Satellite, etc. License:Shareware, $20 to buy Size: 1367KB
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Helen Hunt directs herself in this story of a brittle New York book editor who begins healing old wounds by learning how to surf.
Helen Hunt directs herself in this story of a brittle New York book editor who begins healing old wounds by learning how to surf.
Since moving onto the big screen, however, Kristen Wiig has added a nuanced dramatic edge to her skill set that finds her digging deeper inside…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
Historic Occasion: The Little Rock Nine will be awarded the Lincoln Leadership Prize on May 18th in Chicago
A look at the gifted musicians scheduled to perform at Ebertfest 2015.
Historic Occasion: The Little Rock Nine will be awarded the Lincoln Leadership Prize on May 18th in Chicago
Scout Tafoya's video series continues with a look at Mary Harron's "The Moth Diaries".
An essay on John Glen's 1985 Bond film, "A View to a Kill," in honor of its thirtieth anniversary.
An FFC reviews "The Motel Life", which just played at Ebertfest.
A personal reconsideration of Clive Barker's "Nightbreed" in light of its Blu-ray Director's Cut.
A review of Grace and Frankie, starring Jane Fonda, Lily Tomlin, Martin Sheen, and Sam Waterston.
In another time and another place, "Starlet" could have inspired a short story by Chekhov or O. Henry — a story about two women, one 22, the other 85, who are linked by one of those accidental plot twists explaining why they come together. Indeed, for almost an hour, the story is all the movie is about: That, and performances so effective they're enough all by themselves, even while we know next to nothing about the characters.
Jane (Dree Hemingway) is a leggy blonde, the type who causes people to observe, "she'd be a real beauty, if only she did something with herself." She dresses carelessly, does little with her hair and makeup, lives with two roommates in an apartment building in the San Fernando Valley that you could hardly describe if you had to. She sleeps late, has the first of two or three cigarettes for the day, and takes her pet Chihuahua tooling around in search of yard sales.
She wanders into a front yard so densely planted that she almost doesn't see the old lady hidden in the shadows. This is Sadie (Besedka Johnson), plainspoken, no-nonsense, with not a shred of "sweet little old lady" about her. "Does this hold dead people?" she asks, holding up a possible purchase. "No!" says Sadie crossly. "That's a vase! It's a dollar." Jane buys it. "No refunds!" Sadie tells her.
Jane takes it home, cleans it and is surprised to find that the vase is stuffed with rolls of $100 bills, tightly wrapped in rubber bands. She spends some of the money on a fake-diamond dog halter. Her dog is a male, but the halter says "Starlet," so that becomes the dog's name. The dog doesn't care.
Jane thinks to do the right thing. She returns to Sadie's house, knocks on the door, and can't begin speaking before the old lady snarls, "No refunds!" Jane has a conscience. She trails Sadie in a taxi, pays the taxi to leave, and is waiting for Sadie when she comes out looking for it. She says she'll give her a ride home. Sadie is immediately suspicious. She's even more standoffish when Jane turns up at her table at her church's weekly bingo game. Sadie doesn't warm easily. She's not looking for a new friend.
This may be a spoiler, although the movie's promotion doesn't do enough to conceal it: Jane works for a production company that makes pornos in the Valley. It's a numbing occupation, but Jane hardly seems touched by it. Sex in general seems to mean little in her life, and apart from one mechanical scene, the movie doesn't make much of it. Sadie, in fact, is the most interesting thing that's happened to Jane in a while. She presses herself on the old lady, drives her places, asks her questions.
I learn from Variety that Besedka Johnson, playing Sadie, is a first-time actress who was discovered by the filmmakers at the West Hollywood YMCA. Dree Hemingway is the daughter of Mariel Hemingway, who also played a sexually daring role early in her career, as a Playboy Playmate of the Year in "Star 80" (1983). These two women, so very different, are the film's heart and soul, inviting us to decide for ourselves what's beneath their seemingly obvious facades.
The portrait of the porn industry here suggests a strictly-for-business existence, matter-of-fact, run out of offices filled with computers and file cabinets. Everybody seems to work by routine. Even Jane's roommates, also in porn, are more interested in playing video games. Nor does director Sean Baker seem to make any effort to exploit any particular abilities or cute tricks by the ever-present Chihuahua. This is a low-energy dog who often seems on the lookout for a nap.
All leads up to Jane discovering a way she may be able to spend Sadie's money (which she didn't know was in the vase) on her. This involves Jane's discovery of a fact about Sadie's past that, when it finally is revealed, is a little underwhelming. But the film itself deserves praise for its portraits of these two women and the different worlds they inhabit. And if they instructed Besedka Johnson to make no effort to make Sadie sympathetic, it certainly worked.
Note: "Starlet," distributed by Chicago-based Music Box Films, is nominated for seven Independent Spirit Awards.
This message came to me from a reader named Peter Svensland. He and a fr...
An essay on John Glen's 1985 Bond film, "A View to a Kill," in honor of its thirtieth anniversary.
Scout Tafoya's video series continues with a look at Mary Harron's "The Moth Diaries".
Captain's log: eight fifth graders, one adult, one James Cameron movie.


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City Council
Leader of the Council:
Councillor Sir Albert Bore
Deputy Leader of the Council:
Councillor Ian Ward
Meets at 2.00pm in the Council House on the following Tuesdays:-
To comply with the law and regulations relating to confidential and exempt information part of the meeting may be conducted in Private.
2014 Dates
1 July, 16 September, 4 November, 2 December.
2015 Dates
6 January, 3 February, 3 March, 14 April and 19 May (Annual General Meeting - 4.00pm).
Committee Manager: Phil Wright
Tel No: 0121 675 0216
Email: firstname.lastname@example.com
The City Council with responsibility for approving or adopting the Council annual Budget and the plans or strategies included within the Council's "policy framework" and receiving reports from Overview and Scrutiny Committees.
An Executive comprising the Leader and a Cabinet of 8 Members. The Executive is responsible for all functions except those reserved to the full Council, non Executive functions delegated to Regulatory Committees or the Council Business Management Committee, the Overview and Scrutiny function and the statutory functions of the Standards Committee. Executive Decisions will be made by the Cabinet, Chief Officers in consultation with Cabinet Members, District Committees and Ward Committees.
District Committees and Ward Committees providing representation and decision making at local level and with responsibility for carrying out Executive functions delegated to them by the Executive.
Overview and Scrutiny Committees responsible for scrutinising and reviewing the policies and performance of the Executive and the Council as a whole. They are structured to cover every aspect of the City Council's work. The Health and Social Care Committee also oversees health issues and looks at the work of the NHS in Birmingham and across the West Midlands.
Regulatory Committees comprise of audit, licensing and public protection, planning, standards and trusts and charities.
Council Business Management Committee responsible for planning meetings of the whole Council and other matters that are appropriately dealt with on a 'whole Council' basis or which have been decided are Non Executive functions.
Audit Committee responsible for providing independent assurance to the Council on the effectiveness of the risk management framework and associated financial and other controls for advising on and/or reviewing the effectiveness of other matters referred to it by the Executive, Overview & Scrutiny and Regulatory Committees.
Standards Committee responsible for promoting high standards of governance, advising on and monitoring the operation of Birmingham's Code of Conduct for Members, including determining, reviewing and hearing complaints against elected and co-opted members of the Council for breaches of the Code.
Further details of City Council Meetings.
Birmingham City Council Webcasting


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Education system in India has come a long way. From modest beginnings the country's educational institutions have emerged to attain the status of one of the best destinations for higher studies in the world. Today the country has an array of internationally reputed educational institutions where not only local students study but also students from NRI families benefit.
Most educational institutions in India admit NRI students through their quota systems but for a higher fee. However, the higher fee structure has not deterred NRI students from studying in India thanks to the NRI educational loans available now.


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Oyster #93: Michele Lamy
I've always been extremely short-sighted, so I'm sure I was very reckless in my youth.
Michele Lamy is revered as one of the fashion industry's true eccentrics. She is best known as wife, muse and creative accomplice of gothic-fashion purist Rick Owens, however, this is just a single facet of Lamy's kaleidoscopic life - teenage stripper, cabaret consort, restaurateur, designer, film-maker, defence attorney and philosophical protegee to the late Gilles Deleuze are but a handful of Lamy's past pursuits. The LA club queen has cult appeal, kindled by an intimidating intellect and an awe-inspiring sense of style. In Oyster #93 we asked Lamy what roles beauty and self-image have played in her colourful life.
Renee Warne: I'm fascinated by what you must have been like as a teenager - did you have the same reckless confidence you have now?
Michele Lamy: I've always been extremely short-sighted, so I'm sure I was very reckless in my youth, as the fog surrounding me encouraged me to experiment a lot. The only thing I can be sure of is that my nose was always close to a book.
Your life has been an exotic pilgrimage, with a lot of exploration along the way. Can you explain some of the different phases you've experienced?
In my twenties, I wanted to escape my rich provincial upbringing, so I abandoned studies as a defence attorney to striptease. I was involved in the May, 1968 protests in Paris, and in the early seventies I wanted to be Bob Dylan. My thirties were spent living the Californian Dream surrounded by artists, and giving birth to my daughter Scarlett Rouge. My forties were an entrepreneurial era in Los Angeles where I met my honey, Rick Owens, and I will spend my fifties enjoying life with him.
What is your daily fitness routine?
Hammam [Turkish bath], boxing, weights and stretching.
Always. It's what keeps me grounded! I apply it with an eye pencil and make sure it's not too straight.
You've altered your appearance in some significant and permanent ways, like tattooing your hands and gold plating your teeth. What was the motivation behind this?
To be able to sing King Kong Blues.
As with most things, sometimes it fits, and sometimes it does not. I admire Sang Bleu [tattoo art/fashion publication].
Words: Renee Warne
Photography: Nicolas Hidiro


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The purpose of this study is to determine the safety and effectiveness of giving the drug nivolumab alone and in combination with ipilimumab in patients with advanced triple-negative breast, pancreatic, small cell lung, or stomach (gastric) cancers that have continued to grow or have returned following prior therapy.
Nivolumab boosts the body's immune system by targeting a protein on white blood cells called PD-1. PD-1 normally maintains the balance of the immune system by shutting it down at the right time. Some cancers take advantage of this mechanism by expressing PD-L1, enabling them to escape attack by the body's white blood cells. Nivolumab blocks PD-1, enhancing the body's ability to detect and destroy cancer cells.
Ipilimumab is an antibody against CTLA-4, a molecule that controls a part of the immune system by shutting it down at the right time. Ipilimumab is already approved for treating melanoma, and prior studies have shown that combining it with nivolumab can be very effective for shrinking melanoma tumors. Nivolumab is also approved for treating melanoma, as well as some metastatic squamous cell lung cancers. The use of nivolumab and ipilimumab for treating other cancers is considered investigational.
Patients in this study will be randomly assigned to receive nivolumab alone or nivolumab plus ipilimumab.
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
For more information about this study and to inquire about eligibility, please contact Dr. Margaret Callahan at 646-888-3579.


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Technical design made to move.
Comfort & support all week long.
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Every style of SAXX has a different fit, feel & function.
Use the filters below to find your perfect pair.
What is Modern Fit?
Modern Fit is a slightly slimmer, more tailored fit than a regular boxer brief (but has the same inseam length). Kind of like the difference between slim and regular fit jeans.
Fly versus No Fly?
"Fly" refers to the opening on the front pouch on select pairs of SAXX. Some men prefer to have a fly while some don't use it at all. Use the fly filter on the Shop page to find your preference.
Please note that Ultra used to be called Bamboo and is still made with incredibly soft, natural fibres.
95% Viscose / 5% Spandex
Availability: Out of stock
I got my first pair the other day, most comfortable boxer I'ver ever put on! SAXX for life.


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JJ looks to give Blue Jays sweep of Orioles
Birds out to thwart rival's bid for 11 straight wins
BALTIMORE -- Toronto enters Sunday's series finale with the Orioles scorching hot and looking for a three-game sweep.
The Blue Jays, winners of 10 in a row and now one game above .500 on the season, have had the upper hand in head-to-head matchups with the Orioles lately. They're especially tough on Baltimore at the Rogers Centre.
With Saturday's win, Toronto has now won the season series at Rogers Centre eight consecutive times, going 51-19 over that time. Friday's walk-off victory was particularly thrilling for the Blue Jays and their fans, and it was the second time Toronto earned a walk-off victory over the Orioles this season.
"Our guys don't like losing, their guys don't, either. That's why it's so fascinating to play a game to see which [team will win], which talent wins," Orioles manager Buck Showalter said. "I like watching good people compete."
Showalter has sung Toronto's praises this season -- even when the team was struggling -- and he doesn't sound surprised by their recent 10-game winning streak.
"[The Blue Jays are] a good team. It was a given they were going to play better," Showalter said.
"It's a given that they are hot coming in. It's a given they have a good pitching staff. Look what they paid, they should be getting a return for all the money they spent. They made some good deals, I guess. They paid well for them, and Toronto deserves that."
The Orioles entered Saturday's game still unsure about Sunday's starter.
Freddy Garcia is the most likely candidate. He most recently pitched on Wednesday, throwing a scoreless inning of relief in Detroit against the Tigers.
Garcia faced Toronto earlier this season, picking up his first win of the year by throwing five innings of three-run ball on May 25 at Rogers Centre.
In 10 games this season, including nine starts, the 37-year-old is 3-4 with a 4.80 ERA. He's had a few great starts for the Orioles, but has been inconsistent.
In his most recent start, Garcia gave up five earned runs on two homers in 5 1/3 innings on June 15 in a loss to the Red Sox.
Toronto will counter with Josh Johnson, who is coming off his best start as a Blue Jay. Johnson pitched 7 1/3 scoreless innings, giving up only five hits and two walks vs. the Rockies on Monday. He also struck out 10 batters, all of them of the swing-and-miss variety.
Blue Jays: Reyes' return could force tough call
• With Jose Reyes (left ankle) scheduled to play three full games at shortstop this weekend for Triple-A Buffalo, his return appears directly on the horizon.
Activating Reyes from the disabled list could force a tough 25-man roster decision for the club.
His replacement, Munenori Kawasaki, has become a favorite among his peers, and has filled in capably at shortstop.
Still, he may be sent down in a numbers crunch. Toronto may also elect to demote a bullpen arm, giving the team seven relievers and a four-man bench.
Orioles: Davis gets another day at DH
• Chris Davis got another partial rest on Saturday, occupying the DH spot for the Orioles. With the way he's crushing the ball offensively, though, Orioles manager Buck Showalter has kept his bat in the lineup -- even while giving his legs a brief reprieve.
With first baseman Travis Ishikawa remaining with the big league club, Showalter has used Davis at DH twice in four days, and the team had an off-day in that span, as well.
Davis, who has played in all but one of the team's games this season, had played exclusively at first base before Wednesday.
Worth noting
• Orioles reliever Steve Johnson (oblique) played catch on Saturday for the first time since suffering the injury. The right-hander, who has been on the disabled list since June 6, threw 25 times from 60 feet.
• Orioles starter Wei-Yin Chen (oblique) will throw four innings in a simulated game on Monday before he begins a rehab assignment. The lefty threw a light side session on Saturday, which went well, according to Showalter.
• The Blue Jays have hit nine home runs through five games of their six-game homestand.
Derek Wetmore is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text:
We need a uniform mechanism for hardware discovery.There is no hardware platform available at this point. From a kernel perspective, the aim is to minimise (or even completely remove) the platform code from the architecture specific directory. FDT is currently mandated and there are ongoing discussions for ACPI support.
Currently this is a mess on tablets and smartphones with arm as far as I know.
Having ACPI would make everything a lot easier for software development and shorten the time for hardware integrators and platform makers to release new designs.
We want ACPI, we want ACPI!
Having ACPI on mobile phones and tablets would be awesome from a hardware point of view.
Plus it makes things easier to do, much easier to do.
(Heard that Microsoft is already asking ACPI for things that run windows 8.)
Seems like it's best to add ACPI anyway.


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- Gonat - Apr 14, 2013 at 10:24 PM
I just got home. Even though it was a blow-out, most of the Nats fans stayed hoping for a miracle rally that never happened. 151 games to go. These are 3 of those 50 games that the Nats will lose and frustrate us as fans.On to Miami and back to winning!
- Rabbit34 - Apr 14, 2013 at 10:45 PM
Today was a good preview of things to come. People will see things a lot clearer when they take their heads out of the sand. It is fun reading player comments though and it is fun going to the games but not expecting anything much. So far, so good …. .500 season.
- nats guy - Apr 14, 2013 at 10:51 PM
All I can say thank god for Miami. At least they can't finish in last place. Gotta agree with Rabbit. Not a World Series team unless they get that bullpen fixed. I don't know how they do that now. Not in their prospects and they would have to trade a lot to get some help.
- peric - Apr 14, 2013 at 10:52 PM
Can't really make any kind of assessment until at least 40 games. They do have talent they aren't using such as Tyler Moore. They do have some semblance of cavalry for the bullpen down in Syracuse.What they don't have are viable long-term replacements for Stras, JZimnn, Gio, and Detwiler. But the Braves are worse off in this category so … The offense is anemic and will remain so until Zim gets past his shoulder surgery and Tyler Moore gets in the lineup more.
- JaneB - Apr 14, 2013 at 11:02 PM
Ouch. So. Regroup. Our guys are solid and for real. They will figure it out.
- baseballswami - Apr 14, 2013 at 11:14 PM
Today the Reds blew a five run lead and got swept by Pittsburgh . Remember last weekend? Ups and downs. Not all one or all the other. Tough weekend. They won't all be that way.
- NatsLady - Apr 14, 2013 at 11:16 PM
Remember how good we thought Cincinnati was when we were there? Remember how after week one pundits were saying the Reds were the best team in the NL? They have lost 5 straight. They got swept by Pittsburgh who (cough, cough) everyone had written off. The good news is Espinosa's wrist and the rest that the bullpen got. Henry is a really funny pitcher. Gets the first two out easily, I mean, easily, walks two, throws a crazy wild pitch. Nobody scores. You can't say it's "mental" because there IS no lower leverage situation than today. I'm coming around to Rizzo/Davey's position that Henry just can't manage his stuff. Maybe he will figure it out…BTW, I'm listening on my way home to some game, maybe the Angels, and the announcer says that EJax and some other pitcher combined to throw a record FIVE wild pitches in one inning. Take THAT, Henry!!I didn't see any chops, though there were quite a lot of Atlanta fans there. They were very well-behaved, maybe because of Kids Run the Bases and Puppies in the Park. A lot of people stayed, the crowd was over 39K and didn't start emptying until around the 8th inning. Seems like many people made a day of it, the cafe-restaurants around the park were filled up with people at outdoor tables. Go to Miami and beat up on the Fish, because the Mets will not be a piece of cake. Just like last year they seem decent but will most likely fade after June. Halladay and Hamels both had good starts. Fillies ain't going anywhere.
- Drew - Apr 14, 2013 at 11:22 PM
The Nats are not a bad team. They're a very good team that has lost 5 games to two excellent clubs.The Giants and the Cardinals are excellent, too. The sky isn't falling. We know any one of five teams can win the pennant — six if you include the Kershaws.It won't be beanbag. It will be hardball, but the Nats will be in this thing.Better days are coming. Rendon went 4 for 4 today with 2 doubles and 2 RBIs. He's at .316.
- Manassas Nats' Fan - Apr 14, 2013 at 11:29 PM
Hitting needs to rebound. Last 26 innimgs 1 run 10 hits.
- SonnyG10 - Apr 14, 2013 at 11:50 PM
We will be ok folks. Our winning streaks are comming. Just hang in there.
- Joe Seamhead - Apr 14, 2013 at 11:51 PM
Anyway, I took my youngest grandson to the game for his 7th birthday. Other then the Nats embarrassing effort, we had a great day. He got a Harper jersey, and a cap, from the team store. Then we hustle down the lower level to the Signature Sunday to stand in line for Tyler Clippard's autograph, and he got it. His first pro autograph. Very cool for a seven year old. He was walking on air all day. Unlike some of the bloggers, he like Clip. Just not as much as Bryce.Nats Jack, Not that it did him any good but, Werth went back to Werewolves of London for his third AB walk up song. Not much reaction from the Sunday crowd. Also, Jack, remember to follow your advice you threw out at me this morning. They're not worth it.This team ran into a buzzsaw this weekend, and we went totally flat, along with the crowd after the team started out with the 4-0 lead Friday. By the fourth inning Friday night they had somehow lost the boisterous crowd, never got them, or their game back. I thought that there was a good chance that we wouldn't jump out of the gate and run away with this.We have a tough front end schedule. I saw around .500 for April/ early May and that's looking quite possible. That said, I still think we will ultimately win the NL East. Nobody gets 100 wins in the division, but I'm still saying, "Relax. We got this." You'll see. GYFNG!!!
- peric - Apr 14, 2013 at 11:56 PM
Better days are coming. Rendon went 4 for 4 today with 2 doubles and 2 RBIs. He's at .316.He'll tear up the Eastern League for a couple of months then get sent to Syracuse to make the Chiefs an almost major league team since they also get Chris Young. They'll be as good as the Astros at that point mebbe better. After that? He and others are just a phone call today just like Solano. The BravetyBrave Braves fan twit on the NJ was raving about his farm system. Syracuse easily outclasses the Gwinnett Braves. This year in AAA the Nats should be really pretty damned good.
- Gonat - Apr 14, 2013 at 11:59 PM
Manassas, hard to get going with 2 starters in the 4 and 5 that are swinging at air and worse than that grounding into doubleplays and Espinosa in the 7 is batting a buck seventy-five.
- baseballswami - Apr 15, 2013 at 12:02 AM
Saw a comment on twitter that made me ponder. I am well aware that the guys are not playing up to par, but I have watched most of every game and there have been an awful lot of random little things – not one has gone our way. Players make mistakes, but some you get away with- ours have had consequences that were glaring. Balls have not dropped, have gone directly to a player, they have made amazing plays. But the thing that made me ponder was a remark about Bernie's AB. Horrible, horrible strike calls. At least two not- really- hit batters, bad out/ safe calls, bad strike zones- again, overwhelmingly not in our favor. That kind of bad juju just has to balance out. I mean, it's been two weeks with about two months worth of weirdness. Come on- I am not just being a homer. If you have been watching then you see it.
- peric - Apr 15, 2013 at 12:03 AM
Espinosa in the 7 is batting a buck seventy-five.LaRoche in the 5 is doing worse.
- peric - Apr 15, 2013 at 12:05 AM
They're not going to hit for a lot of power particularly acute given Zim's ongoing rehab and recovery from the shoulder surgery. No matter what you say it is what it is. And you just have to accept it if this lineup stays the same.
- Gonat - Apr 15, 2013 at 12:19 AM
peric said… Espinosa in the 7 is batting a buck seventy-five.LaRoche in the 5 is doing worse. April 14, 2013 8:03 PM _____________________________peric, LaRoche is but his contact has been better. In small sample sizes unlucky BABIP of 2 or 3 that could've been hits will skew it to super ugly. Think about it.
- Unknown - Apr 15, 2013 at 12:43 AM
I like Span's comments – veteran sizing up the job at hand and realizing he and his teammates need to get better fast to keep up.Don't like Danny's comments at all. "I still think we're better"? That sounds like D-Hall and the rest of the Skins with their endless stream of hubris even after they've gotten their arses kicked, like what happened in this series.Danny needs to grab some splinters until his play improves and his mouth shuts. Rendon is knock-knock-knocking on the major's door, Danny-boy and it's a results-based league and you and the Nats ain't measuring up right now.Let your play talk for you – this series' speaks volumes….
- peric - Apr 15, 2013 at 12:45 AM
peric, LaRoche is but his contact has been better.Either way … he is off to a slow start.Danny's rotator cuff still concerns me.
- peric - Apr 15, 2013 at 12:52 AM
Harper hits the cover off the ball the beginning of the first game. They adjust to him and shut him completely down the rest of the series. End of offense ending with the coup de grace … a nine to nothing shutout and shutdown. That tells me the only hitter in the Nat's lineup they fear is Harper. With Tyler Moore that doesn't happen.
- Secret wasian man - Apr 15, 2013 at 12:59 AM
Its not bad JU JU. Its bad play. especially from Zimm and LaRoche at the plate. This team quit today. Something you did not see last season. That is worrisome.
- peric - Apr 15, 2013 at 1:05 AM
Some people also reported that Harper stopped hustling …
- Whynat - Apr 15, 2013 at 1:06 AM
Agree that I don't like espy and stras's recent comments about being better. Keep your mouth shut and let your play do the talking. Braves beat em three different different ways: come from behind, duel, and absolute beat down as the capper. I'm tired of hearing how good they are. I want to see it. It almost sounds like they are trying to convince themselves.
- John C. - Apr 15, 2013 at 1:06 AM
Rabbit34 and nats guy should change their handles to "eeyore1" and "eeyore2." Always with the negative waves!
- peric - Apr 15, 2013 at 1:15 AM
U Make the CALL: who is worse?D. Espinosa: 40 AB, 6 SO, 2BBA. LaRoche: 34 AB, 10 SO, 3BBD. Espinosa: 4 2B, 1 HR .175/.233/.583A. LaRoche 0 2B, 2 HR, .147/.216/.540
- MJR - Apr 15, 2013 at 1:19 AM
Going back a couple of posts to Swami's comment about de Rosa and Mikey Mo…I was thinking the same thing. The entire team looks stiff and serious…they're not clicking, not having fun. Could be that they've lost some of that positive mojo those two guys brought to the clubhouse last year and that's having an effect on their collective psyche. Loosen up boys…it's your job…but it's still a GAME.
- SonnyG10 - Apr 15, 2013 at 1:25 AM
I disagree with "Unknown" and "Whynat" regarding Danny's and Stras' remarks about being better than the Braves. If you want to be the best, then you must think you're the best. The whole team needs to believe they are the best and it doesn't bother me one bit if they say so. At least I know they're thinking the right way.
- nats guy - Apr 15, 2013 at 1:32 AM
Hey John C.I never attacked you personally. I stated what I see as a problem. They have no bullpen. I didn't call you a name. Cut out the personal digs. After the season is over we'll see who is correct. It's only a game and I have been watching it since the Senators of 1961. I have said the defense will right itself and I have not been beating up Ryan Zimmerman. I do think they are going to have a very long season unless they find a way to get a bullpen.Cut out the personal shots!!!!!!!!
- Gonat - Apr 15, 2013 at 1:41 AM
peric said… U Make the CALL: who is worse?D. Espinosa: 40 AB, 6 SO, 2BBA. LaRoche: 34 AB, 10 SO, 3BBD. Espinosa: 4 2B, 1 HR .175/.233/.583A. LaRoche 0 2B, 2 HR, .147/.216/.540_________________________________________I watched or have been at all of the games and I will say they are both a disappointment.
- Whynat - Apr 15, 2013 at 1:42 AM
Baseball highlight for me today was steady Eddie's glove find. It's a beautiful game and that episode captured it.
- Eric - Apr 15, 2013 at 1:43 AM
Somehow I am more relaxed about everything now. I dunno why. Thomas Boswell had a great article in the Post a couple of weeks ago about how no team catapults directly to the WS in their first winning season. They need to learn how to choke and lose and then…just let it go.Honestly, I don't think the Nats have emerged from playoff mentality yet. I know I only just did during game two of the series with the White Sox. Zimm's throw to second yesterday reeked not of a lingering injury to me, but of panic. In a perverse way (that Boswell put much more succinctly than me), I think these kinds of losses will ultimately help them. Staying on the good side of 500 will help ensure it doesn't sink them when it happens.But, we'll see.
- peric - Apr 15, 2013 at 1:55 AM
Yep just have to wait and see how it all winnows out.
- Ivan Tuski - Apr 15, 2013 at 1:57 AM
Matt Stairs
- Eric - Apr 15, 2013 at 2:01 AM
PS…if I may expose my n00b…what does GYNFG stand for?
- John C. - Apr 15, 2013 at 2:04 AM
No personal offense intended, nats guy; I view "Eeyore" as pretty mild way of suggesting that all is not darkness & doom. Of course, I've been on a show this weekend and so didn't have to sit through these three games. But I've sat through worse, even last year.
- Manassas Nats' Fan - Apr 15, 2013 at 2:04 AM
wish I had the numbers after 12 games last year to compare.this yearRuns 11thERA 11thFielding 15thIn all three areas we are bottom third. Despite that still 7-5.
- Ivan Tuski - Apr 15, 2013 at 2:10 AM
Go you freakin Nsts go. (I had to ask last year)
- mick - Apr 15, 2013 at 2:11 AM
This comment has been removed by the author.
- mick - Apr 15, 2013 at 2:12 AM
I like the Stras, Ian and Danny stating "I don't think the Braves are better than us" However, I remember a certain character in an old Monty Python movie who was cut down to the stub by the black knight proclaiming "I got you right where I want you"lol
- peric - Apr 15, 2013 at 2:12 AM
And for Nats fans? Its Matt "Stares".
- peric - Apr 15, 2013 at 2:13 AM
Its just a flesh wound you Tomahawkers!
- peric - Apr 15, 2013 at 2:15 AM
The best news is the return of the heirloom glove. May seem like a small favor but in the grand scheme of things maybe its at least bigger than the Braves series.
- mick - Apr 15, 2013 at 2:17 AM
"its just a flesh wound, I'm invincible, come back here Braves!"lol
- mick - Apr 15, 2013 at 2:17 AM
lol peric
- SonnyG10 - Apr 15, 2013 at 2:22 AM
peric said…The best news is the return of the heirloom glove. May seem like a small favor but in the grand scheme of things maybe its at least bigger than the Braves series.April 14, 2013 10:15 PMI second this comment.
- mick - Apr 15, 2013 at 2:27 AM
Good night my Insider friends, in addition to being a sports fan, I am a Monty Python nut from back in the day and I leave you all with…….Some things in life are badThey can really make you madOther things just make you swear and curseWhen you're chewing on life's gristleDon't grumble, give a whistleAnd this'll help things turn out for the bestAnd always look on the bright side of life……lol
- Gonat - Apr 15, 2013 at 2:34 AM
Eric said… PS…if I may expose my n00b…what does GYNFG stand for?_______________________________Go You Friggin Nats Go
- Eric - Apr 15, 2013 at 2:52 AM
Grazie all, re: GYFNG.
- Section 222 - Apr 15, 2013 at 3:03 AM
Eric, welcome. And if you want, check out the NIDO Spreadsheet, on the tab called Glossary. Lots of Insider lore there, including definitions of GYFNG, PFB, and other frequently used shorthand.
- Eric - Apr 15, 2013 at 3:18 AM
Haha, awesome, y'all don't mess around with yer lingo .
- Gonat - Apr 15, 2013 at 3:22 AM
Sect222, the Glossary is very nice! You are missing "Sweet Holy Moses" from Mark and some of the great FP terms we use like the 5.5 hole and "there goes the no-hitter".
- Gonat - Apr 15, 2013 at 3:24 AM
Sect222, and Trust but Verify
- peric - Apr 15, 2013 at 3:25 AM
And there's some missing … things like "tweeter" … and Bryce's dog Swag for that matter … the "Magnolia Muscle".
- peric - Apr 15, 2013 at 3:28 AM
And there's worse news …Its almost tax day.
- peric - Apr 15, 2013 at 3:34 AM
And good news? Jeff Kobernus was left out of two games … the home opener and the 1st game of today's double header. In the second game he went 3 for 4 scored a run and swiped a base to make it 5.Jeff Kobernus is now batting .556.
- peric - Apr 15, 2013 at 3:38 AM
Make that 2 bases swiped. Kobernus might swipe a good number before the Chief's are through.
- peric - Apr 15, 2013 at 3:38 AM
Remember that Chase: Jeff Kobernus .556 average.
- sjm308 - Apr 15, 2013 at 3:40 AM
OK – I have stayed away after listening to all of the game while doing yard work.Pleased to see there is nothing horrible here. Lots of worry and legitimate concerns.Gonat – I would say that two of these games would fall in the 50 we were going to lose no matter what but not that first one. We gave that away and that is one of those games that honestly matters. If you have 50 you are going to win and 50 you are going to lose and the other 60 are the key, that first game was one of those. We should have won that one.Like Peric, I want to wait till 40 games but I am concerned about all the errors. I have to think we are leading the league in errors right now and that is not a good thing. I can deal with poor plate production since that will usually work itself out but the errors bother me. That is basically lack of focus.Have to get back to winning 2 of 3 and we have two great series to do just that.Go Nats!!
- Section 222 - Apr 15, 2013 at 3:48 AM
Excellent additions Gonat! (Btw, I think Mark actually says Sweet Fancy Moses.) Others may elaborate on your definitions or descriptions of their origins, like I wonder if someone could find the first time Mark said Sweet Fancy Moses on this blog. It would be cool to know what the play was that inspired him to use that great expression. The Glossary and other tabs on the NIDO Spreadsheet represent the collective work and intelligence of a great and growing community. Not to mention a whole lot of drinking if we were ever to pay our debts!
- Gonat - Apr 15, 2013 at 3:49 AM
sjm, you are right. Painful.
- peric - Apr 15, 2013 at 4:29 AM
Meanwhile the Chiefs are starting the year out swimmingly in spite of the cold, wet rain, and the ever present chance of snow this early in the spring. I'm not sure what Rizzo, Clark, Harris, and Beasley told them but whatever it is its working for a major part of the Chief's roster. They may soon get Rahl or Komatsu and both are better than Eury Perez placed on the DL with the wrist. Plus, Rendon should be on his way to the International League eventually … Nate Karns is pitching better as a starter but most of our 'pseudo' scouts still believe he will end up in the bullpen. I guess we'll see … I always fancied him a starter but that was before the shoulder surgery …
- NatsLady - Apr 15, 2013 at 9:51 AM
Seamhead, I'm with you. Last year the Nats got swept by the Dodgers and came home dragging and lost another one. Also lost a tough sweep to the Yankees, plus that 9-0 game. When Atltanta came out of the gate 13-1 in 1994, guess who caught up and overran them–your Montreal Expos. Just play one at a time, boys, one at a time.
- Gonat - Apr 15, 2013 at 10:14 AM
So far the Nats have done a great job of beating those teams they should be beating.We all know the Braves series started out wrong and the Braves got the momentum. It happens.Now time to look forward.
- Another_Sam - Apr 15, 2013 at 10:45 AM
I just looked in the paper. There's another game coming up. The score in that one is 0-0. Play ball.
- Section 135 - Apr 15, 2013 at 11:31 AM
Zimmerman should be called out for his poor play. He basically lost two games in this series. He looks slow and overweight; his hitting is weak; he should not be in the 4 hole; his defense is a liability and he appears to not care. I'm sure he'll eventually get hot, but I expected more out of him
- baseballswami - Apr 15, 2013 at 11:34 AM
I have a friend that posts quotes every morning. Today it is — the good thing about the future is that it happens one day at a time. Lincoln. Appropriate for the day. I think a lot of us got ahead of ourselves and started thinking October when it's only April. And also maybe we were thinking Fairy Tales and we are getting reality tv. There is a lot of uh-oh, and what the heck is wrong with the Nats? Guess we all have to watch it play out over the next 5-6 months. And that is a long time. We did not even know what the post season would look like in August. I can't live all mad and frustrated. I am going to have to take this one game at a time and realize there are no guarantees.
- Gonat - Apr 15, 2013 at 11:41 AM
http://www.milb.com/milb/stats/stats.jsp?gid=2013_04_14_haraax_altaax_1&t=g_box&did=milbGet excited about that boxscore. Rendon and Goodwin leading the way.
- Steady Eddie - Apr 15, 2013 at 11:53 AM
Whynat, peric, Sonny from above and everyone else who made thoughtful comments on the game thread — thanks for your thoughtfulness on the glove finding. While I was prepared to let it go as it's only a replaceable "thing", it's much better to actually still have it for our daughter and family.And thanks especially to our friend who endured a really bad ball game and exerted himself across multiple parts of the stadium to reclaim it.
- Another_Sam - Apr 15, 2013 at 11:59 AM
Swami — you nailed it again. Thanks, man.
- NatsLady - Apr 15, 2013 at 12:30 PM
Steady, glad you got the glove and glad you have good friends!!!
- natsfan1a - Apr 15, 2013 at 1:33 PM
Great news, Eddie!


text: Excerpted from Cover-up: Mystery at the Super Bowl (The Sports Beat, 3) by John Feinstein. Copyright © 2007 by John Feinstein. Excerpted by permission of Yearling, a division of Random House LLC. All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.


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How do you unblock facebook and youtube at work without anyone finding out? My job recently installed a firewall that blocks facebook and youtube, how do I unblock it without setting off any red flags.
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I have an observation and a question. How do male and female gamete cells divide their genes so there is minimal genetic redundancy within the offspring? For example, if I could clone a male and female, from one of their cells, each has the DNA needed to make, 2 eyes, 1 nose, 2 arms, etc. If we next look at their gamete cells, the DNA divides in half, but needs to do so in a way that will not result in 4 eyes, 2 noses or 4 arms within the offspring. The division of the DNA needs to be ordered for both the male and female, so we end up with only one set of genes for each of the above. We can end up with our mothers nose and father eyes, but not both our mother and fathers eyes (4). I can sort of see how the female gamete cells might do this since they extrude the extra DNA. But with male sperm cells, all the DNA is used. Does this means that half the sperm cannot merge, by default, via some membrane screening mechanism? If sperm attachment was random why not four eyes half the time?
We are diploid. Each of our 23 chromosomes are paired, one from from each parent. Gametes are produced by meiosis, which randomly combines mother and father DNA by the process of crossover: There is no redundancy, just a lateral shift of randomly crossed segments. This is nature's way of randomly shuffling the traits between the parents at the moment the gamete forms. But the gamete is haploid, having only 23 single but interspliced chromosomes. In fertilization, gametes join, to form the zygote which will incorporate DNA from both parents. The zygote will split for many generations, then cleave into a spherical blastula, from which will develop the body. The zygote has 23 pairs of of chromosomes. Here's a site that may be helpful: http://leavingbio.net/CELL%20DIVISION.htm
Normal cells in your body are diploid cells, containing 23 pairs of chromosomes. Each chromosome is a long strand of DNA. Most of the paired DNA is the same. Areas where a chromosome is (potentially) different from its partner are called alleles. Loosely speaking, the DNA that makes things that are the same for all humans (2 eyes, 1 nose, 2 arms, etc) are in the bits where the two halves of the pair are the same. The things that are different between different people are in the alleles. Now. Sperm and ova are are haploid cells, containing 23 single chromosomes. Haploid cells are made in a process called Meiosis: When a sperm fertilizes an ovum, the chromosomes pair up to make a diploid cell.
O….M…..G……. So, let me get this right. You spam the B&G subforum with endless pronouncements and lectures about how life and cells and DNA and evolution works (which I have mostly moved here for collective evidence), and here you demonstrate that you don't even understand some of the most basic genetic concepts, namely diploidy and meiosis. I think it's time to start treating you like a full on pseudoscience troll that you are.
Are you thinking about the polar bodies that are formed during oogenesis, as an oocyte develops into an ovum? That's meiosis, which also happens in spermatogenesis. The difference is that each spermatocyte makes four separate spermatids during meiosis, while an oocyte only makes one ovum, while the other three cells become polar bodies (if I remember rightly they kind of hang around in the ovum for a while and are eventually broken down.) Corrections welcome. I'm reasonably pleased with how much of this I remember, considering it was crammed in to the repro module around lots of pathology, anatomy, psychosocial stuff, and all the other repro physiology and I never studied biology before... but I do love Wikipedia for the quick confirmation and vocabulary reminder.
HR, it appears that the others are still giving him a chance to learn, notwithstanding his trolling. In that vein, it should be mentioned that in many organisms (land plants, sea algae, etc.) the adult phase is haploid, from which are produced haploid sex cells which then fuse to form a diploid zygote which then immediately undergoes meiosis, forming cells that grow into the adult form as haploid. In some species, the adult form can be either the haploid or the diploid. This is also true for some animals, such as bees, wasps and ants which develop from unfertilized haploid eggs, are therefore haploid in their adult form. Sex is more complex than most people realize. http://en.wikipedia.org/wiki/Haploid#Haploid_and_monoploid
That is why the thread remains open. :thumbsup: DNA from the Beginning is one of the best genetics tutorials I have found. It provides a comprehensive coverage of classical and molecular genetics using graphics and animations.
I like that link you gave. The presentation format is very good about removing information clutter and not too many clicks to access any page. I also like the biographies, to help remind us how this knowledge was uncovered. This is an excellent chance for wellwisher (and any other person who had problems with evolution) to recognize how truly random mutations can be. Once you accept that the chromatids naturally exchange DNA, and how truly random that process is, it takes only a little contemplation to recognize that other "unintended" kinds of DNA alteration can also randomly occur. (I mention this since the notion of randomness seems to clash with the fundamentalist doctrine of determinism.) Thanks for the link. I, for one, enjoy it.
I was more concerned with how does an integrated animal or human form, without redundancy in some of its many bulk systems (eyes, nose, liver, etc.) using a random separation and recombination of genes? If there are both male and female genes for eyes, how does it only pick one and not both or one of each? I could always follow what was presented, but this does not answer all the questions. in terms of the final integration of a lifeform from a combination of random and redundant genes. Some method of order would make more sense. As an analogy we have two puzzles. We split each puzzle into two and then merge the two halves to get a third. If you try to built this composite puzzle, the puzzle will be incomplete the vast majority of the time.
Your question is very confused; I can't understand what you're asking. Are you asking how does a diploid offspring inherit one paternal and one maternal allele for each gene? The answer is meiosis – use the above links to clarify this process. Or, are you asking how does a given cell know which allele of a given gene to use? The answer is that for the significant majority of traits both alleles (the paternal and maternal alleles) of a given gene contribute to the trait. That's an inaccurate analogy for the transmission of alleles from parents to offspring. Again, an understanding of the process of meiosis (and chromosomes, and alleles, and sister chromatids, and DNA replication) would clear this up. Contrary to what you have said, following the above links will answer all the questions.
There are a few answers to your question: 1) There's no such thing as "male and female genes for eyes." The alleles that code for your eyes are spread across your genome. 2) Male and female genomes are different only in one pair of chromosomes, the familiar XX and XY chromosome pairs. ("XY" denotes one standard looking chromosome and one truncated chromosome.) The SRY gene (sex-determining region of the Y chromosome) is what makes males males. This doesn't always work, and thus you can have a phenotypic female with an XY genome. 3) Rarely is there a geographic mapping for any trait i.e. "gene HOX21A codes for your left eye." There are hundreds if not thousands of genes that code for eye development. For example, one set of genes creates the ectoderm germ layer during very early development; another set causes a portion of that layer to thicken and produce a cornea from that layer. There is a method of order; research the HOX gene complex, for example. However there are a tremendous number of genes that go into every structure, with a lot of redundancy. You can remove a single gene and often its partner on the other chromosome will take over for it. You can remove both and 99% of the time other genes will compensate. You have to hammer a genome pretty hard (like put an entire extra chromosome into the genome, or take an entire one out) before you see serious problems - and even then, sometimes the human it codes for survives, albeit with serious deficits. Ah, but the genome is not like a puzzle. It's more like a hologram. Take away a little of the hologram and you still have the complete image. Take away a little more and it gets more grainy - but it's still all there. Mix two holograms any way you like and you'll get a superposition of two images, one on top of the other.
Your analysis suggests the entire DNA, is like a team, which is more than the sum of its parts. If we remove genes, other genes can compensate, because the team still adds up to more than the sum of the parts minus one.
That's probably it. What he needs to learn about is Dominant versus Recessive genes. Mutations usually create a deleterious recessive (if passed down through the generations, and subsequently inherited from both parents, results in a deleterious situation, usually fatal; if only one inherited, then the other comparable gene (allele) from the other parent becomes the only functioning one (Dominant). You got any good references for him/her to read up on that?
In many cases yes. The most common case of this is homozygousity (now there's a word of the day.) That's the case where we have two alleles for a trait, one on each paired chromosome. This is also one of the keys to standard Mendelian genetic inheritance. For example, let's say you have an important set of genes that codes for red blood cell shape. Normally you have two of these, one on each chromosome. In some cases one might be defective. You might expect that would result in malformed red blood cells, but the intact genetic information on the other chromosome compensates for it. Thus you can be heterozygous for sickle cell anemia (i.e. be missing the correct genes on one chromosome) but never notice anything wrong. It's only if _both_ chromosomes are damaged that you notice anything wrong. And even then it's not instantly fatal. Even before medical care people sometimes lived to age 20 or so, and nowadays people with sickle cell anemia can live to age 50 or 60. That's because there are enough "backups" in our biology to compensate for the distorted shape and impaired function of the malformed red blood cells characteristic of sickle cell anemia.
In order to understand how organs arise from the zygote, you need to understand cell differentiation. Remember, the zygote starts as a single celled creature having all of he DNA to produce the multi-cellular creature. How does that happen? How do some cells become bone, others feathers, etc., when they all carry the same DNA? Here is an illustration of the development from zygot to blastocyst, which is where the embryonic stem cells are born: Here is an animation of that process: http://www.youtube.com/watch?v=IxFwenTA-gQ and here is the process that will lead to body and organ differentiation: http://www.youtube.com/watch?v=uaedzlrnBGY&feature=related As you see, the DNA is the a very unusual kind of program, that is multi threaded, and based on digital (codon) and analog (gradients) "language".
What I see are chemical gradients, such as in the early blastocyst stage. The morula stage is symmetrical and lacks a gradient. This might be as far as it can go. It needs a potential to set a gradient before it can go any farther. In the human body, the primary chemical gradient appears to be between the nervous system and the blood supply. This is inferred from the exterior membrane potential of neurons with is positive/maximized, and the blood supply which is slightly alkaline or slight negative charge. The ratio of these (net potential in the context of ratio and quantity) helps maintain differentiation. As long as the gradients are not damaged the configurational equilibria (team shape) associated with the DNA can develop normally. The configurational equilibria on the DNA (team shape) made easier by the way chromosomes are organized. These are also in the form of gradients. This is inferred based on aspects of the DNA remaining packed, while unpacking depends on chemical equilibrium. We have an external gradient imposing external potentials, which impact the potential gradient at the membrane (membrane potential), which impacts the genetic gradient. This allows the genetic teams to be more than the sum of its parts. If we lose one gene the equilibrium DNA configuration redistributes in 3-D.
Keep in mind the gradient shown was inside the embryo, not an external influence. And this is not a chemical gradient per se, but a variation on the concentration of proteins that will turn on transcription factors inside the stem cells, to promote further differentiation. What you are seeing is programmed mutations taking place in a way that fast-forwards through the countless stages of evolution, yet implemented by forcing the transcription factors to unzip and express particular genes, even if these are only needed to build the banded regions where future generations of stem cells will "evolve". The clip shows how nature exploits chemistry in ways that defy simplification, or the imposition of "reasoned" design. The complexity is traced to stages of development, from the earliest of notochords (flatworms) to vertebrate marine animals, amphibians, reptiles, birds, and tetrapods, which bridged the evolution from reptilian to mammalian forms. Each stage of evolution introduces "tweaks" but preserves huge inherited chunks of chemical processing layers in embryonic development. This gives further incontrovertible proof that "design" is by natural selection, nothing more, as the refinements seen in embryogenesis encapsulate the successes of prior life forms, retain them, and reuse them simply because they work and are handed down genetically. As you see, once life forms were able to produce one "stripe" by this method, nature has arrived at 14 stripes by the time we get to the mosquito. And each of those stripes becomes a zone for further specialization to a body part, so if zone 10 were to represent the shoulder area, that is where the appendage for the front legs will further develop, from a bud. The human embryo follows the exact game plan. As mentioned by billvon above, a thousand genes may be involved in the development of a particular organ. A particular gene has such a specific purpose, that the overall effect, to produce a particular organ or tissue, is only possible because hundreds or thousands of these interactions are carried out in sequence upon sequence, until each of the 200 or so different cell types (in the human body) are completely and finally differentiated out of the stem cells that work their magic during early development. We talked about the development from zygote to blastocyst, which is the hollow sphere, and you saw the genesis of the embryonic mass, where the stem cells arise in the banded regions. What I would like to show you next is what happens as the embryo first starts budding and amassing primitive structures that are localized to each band, and yet able to maintain a connection, like a string of pearls, so the body plan remains continuous, yet able to differentiate locally. This next clip begins where we left off, only here we see the early embryo from outside, as the striped zones begin to specialize further. You will see a flat substrate, which is the embryo itself. This shape proves we evolved from reptiles, because they needed more yolk to survive egg deployment on dry land. The space needed by the yolk required a flat embryo. Mammals don't require a yolk, but we inherited the flat structure, because nature had already designed it, and nature doesn't fix what aint broke. From this flat embryo a "primitive streak" develops. This is inherited from worms. The notochord they possess appears out of the streak, and will form two ridges. What happens next is a folding and curling that was worked out in early vertebrates to form the spinal tube and neural crest from which the vertebrae, spinal chord and brain will bud and develop. What you see playing out is a reenactment of evolution, in stage upon stage of formation and refinements added by mutation upon mutation. Yet these stages are stitched together seamlessly, so the transitions of 400 million years pass before your eyes in moments, or in a few weeks in the life of a human embryo. Notice that the embryonic disk differentiates into germ layers (ectoderm, endoderm, mesoderm) that each follow their own specialized tracks of development in this process, which is called gastrulation: http://www.youtube.com/watch?feature=endscreen&NR=1&v=iHmBIJs77ZQ and here you get a mapping between the germ layers and the systems, organs and tissues that will continue to differentiate within them: http://www.youtube.com/watch?v=jblUFQIi_VY


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Originally Posted by Intel PRRIO RANCHO, N.M., Feb. 26, 2007 -- Intel Corporation today announced that it will invest $1 billion to $1.5 billion in its Rio Rancho site to retool Fab 11X for production on Intel's next generation 45 nanometer (nm) manufacturing process. Fab 11X will be the company's fourth factory scheduled to use the 45nm process, with production in New Mexico scheduled to start in the second half of next year.
Marking one of the biggest advancements in fundamental transistor design in 40 years, Intel's 45nm high-k and metal gate process consists of an innovative combination of new transistor materials that drastically reduces transistor leakage and increases performance. When 45nm production begins later this year, the company will use a new material with a higher-k (dielectric constant), and a new combination of metal materials for the transistor gate electrode. Extending its lead over the rest of the semiconductor industry, early versions of Intel's next generation 45nm family of products - codenamed Penryn - are already running multiple operating systems and applications, and the company remains on track to begin 45nm production in the second half of this year.
"Our new 45 nanometer process represents one of the most significant manufacturing breakthroughs in decades and we believe that putting it in our factory in New Mexico will help us deliver the best possible products for our customers," said Paul Otellini, Intel Corporation's president and chief executive officer. "Our Rio Rancho site has successfully operated in New Mexico for 27 years. Based on that success, we are pleased to position Fab 11X for Intel's next generation of technology."


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Top Definition
When your dog lays down on his back and sticks his belly out for you to rub! Gotta love it, it's so cute! :)
I luv my wittle Murphy!
de Innocent Girl
3 janvier 2005
1 more definition
if a man wants to fuck a woman he could use this expression. it implies he has a large enough cock and a hard enough boner he could "rub her belly from the inside" when he fucked her.
hey babe, wanna a belly rub
de dirty.diana
27 juin 2009


text: General forumsLatest Post: Started By: Latest Topics cupman What the USA was really built on Posts: 1 - We are les to believe that this country ( and the world) was built on freedom. Those freedoms have left us all greedy. MarineMother Remove Tag-Days from Schools Posts: 3 - Isn't it time to remove this practice from our school systems? Doesn't it seem hypocrytical to teach thousands of children that it is alright to beg for free money to play games, get new costumes,... patriotsfan Area children destroying neighborhood Posts: 1 - I dont understand why some children are left to do as they please without any supervision. Lately a couple of people moved to the area with several children. These kids are left to do as they please. SonofThoth New Director of Prendergast Library has a horrid history Posts: 0 - Take time to do a thorough and exhaustive internet search of the name Linda Mielke and you will see a woman who has betrayed librarianship, betrayed librarians, and dumbed down entire collections... Deligiannidis THE CALCIUM FACTOR The Good, The Bad and The Ugly of Calcium Posts: 0 - Raw materials of calcium can also be absorbed from the following sources: Broccoli, Kale, Spinach, Collards, Turnip Greens, Cabbage, Cauliflower, Beans, Lentils, Nuts, Figs, Dairy Products, Salmon... Orangutanman Save money on electric bill Posts: 0 - A few months ago I signed on as a customer with a company called Ambit Energy through National Grid (my electric provider) and it's worked out well. meetoo Where have all the plows gone ????? Posts: 0 - WOW ...Can someone tell me where all the plows were this morning. I head to work around 5:30 and no plows out this morning, hard a real hard time going anywere on Baker St. Lets see... Pinochi1 Weitsman scrapyard location Posts: 0 - In response to the gentleman from Kennedy that feels that the scrap yard located on 8th St should petition Jamestown for a location in one of the industrial districts already establishe. PinkWhstle Attack on breast cancer research Posts: 0 - I will start by saying that I was born and raised in Jamestown (JHS 61) and both of my parents were life long Jamestown residents. Soderberg Foote Ave & Main St Intersection Needs to Go! Posts: 0 - Is Jamestown doing away with the lane merge at the Foote Ave and Main St intersection? I'm talking about when you're heading towards the bridge on Foote Ave. hulahanna1968 Christmas Spirit Still Survives Posts: 0 - My family understood that present-exchanging would be limited this year. Some presents would have to wait until my next paycheck. danyay First Posts: 0 - With over 60,000 comments on the Post Journal's website in the past two years, I think it's only appropriate that I, with 2.3% of them, start the first forum post ever. Nice addition to the site. |


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Marlins ask Alvarez to step up again vs. Angels
Wild Card hopefuls tab new ace in rubber game with Santiago, Halos
When Jose Fernandez went down, Henderson Alvarez filled some big shoes. The 24-year-old Marlins righty has taken on a leadership role, and for the first time in his career, he's an All-Star and a 10-game winner.
Alvarez picked up victory No. 10 at Colorado last week, and he looks to build on that number in Wednesday night's series finale in Anaheim.
"We talked about when Jose went down about having guys step up," manager Mike Redmond said. "Henderson became the guy who really came to that forefront. He's definitely that guy."
Alvarez has had success against the Angels, but it came when he was with the Blue Jays.
In three career starts, the Miami right-hander is 2-0 with a 1.57 ERA in 23 innings.
"Henderson has been our most consistent starting pitcher," Redmond said. "He's pitched in some big games. I think everybody feels when he's on the mound that we have a great chance to win."
A win would bring the National League Wild Card-hunting Marlins back to .500, but to do that, they'll have to get through Angels left-hander Hector Santiago.
Santiago has never faced the Marlins. Not helping matters either is that the first-place Angels haven't won any of Santiago's four starts this month. But that doesn't mean he's pitched poorly.
The first-year Halos hurler has only allowed five runs in 22 1/3 innings in August, good for a 2.01 ERA. Santiago surrendered seven hits and two runs (one earned) in his most recent outing against the Athletics on Friday. That was a game the Angels would lose, 5-3, but Santiago wouldn't factor in the decision, extending his streak without a loss since June 15.
Santiago has also received two runs or fewer of support 10 times this season. And with Angels moving ahead of the Athletics for the best record in the Majors following Oakland's 4-2 slip-up vs. Houston, Wednesday would be a great time to finally give Santiago some offense.
Marlins: Hatcher stepping up in bullpen
The bullpen has been a strength of the Marlins, but now the unit is without one of its most reliable right-handers. Bryan Morris was sent back to Miami on Tuesday night to have his right hip evaluated. Morris is dealing with some discomfort after pitching on Saturday in Colorado.
While Morris is out, the Marlins will be looking for others to step up.
Chris Hatcher is one candidate who could help in the late innings. Hatcher has 49 strikeouts in 44 1/3 innings to go along with a 3.05 ERA.
"He's been one of those guys that have come in and done a nice job," Redmond said. "He's pitched some big innings for us.
A former Minor League catcher, Hatcher is progressing as a pitcher. The Marlins feel lucky to still have him, because before Spring Training, he was taken off the roster. Any club could have claimed him, but none did.
Hatcher is out of options, but he continues to make a case to log important innings.
Angels: Herrera not sharp in return to bullpen
The Angels called up right-hander Yoslan Herrera on Tuesday, largely based on the positive reports they were receiving from Triple-A Salt Lake. But after the first appearance of his return to the big league club, he wasn't exactly receiving any rave reviews.
Herrera came on in the ninth to close out the Angels' 8-0 lead and proceeded to serve up the Marlins' only two runs of the evening.
Following two doubles and two singles, Herrera finally got the job done. He'll just need to do better than that if he's looking to pitch in more high-leverage situations.
The Angels would have certainly liked to have seen better as well, considering their relievers had tossed 36 2/3 innings in their previous 11 games entering Tuesday.
Worth noting
• The Marlins activated Derek Dietrich (right wrist sprain) from the 15-day disabled list Tuesday and optioned him to Triple-A New Orleans.
• Entering Tuesday, Angels pitchers had a 3.03 ERA (116 earned runs in 344 1/3 innings) since the All-Star break, which ranked fifth in the Majors.
Cody Ulm is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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A parathyroidectomy is a surgery to remove parathyroid glands. There are four parathyroid glands located in the neck. The glands make a hormone that balance the level of calcium in the blood.
Reasons for Procedure
The surgery is done to remove one or more abnormal parathyroid glands. The glands can be abnormal due to cancer or for other reasons.
A minimally invasive approach is usually done if only one gland needs to be removed. If more than one gland needs to be removed or if the doctor needs to do additional surgery in the neck, a conventional approach may used instead, which involves making larger incisions.
Possible Complications
Problems from the procedure are rare, but all procedures have some risk. Your doctor will review potential problems, like:
- Bleeding
- Hoarseness
- Low calcium levels in the blood (more common if all four glands are removed)
- Wound infection
- Reaction to the anesthesia
- Skin tethering—tissues and skin may become attached to the voice box or windpipe
- Scarring
- Blocked airway
- Damage to nerves (which can cause problems like paralyzed vocal cords)
Before your procedure, talk to your doctor about ways to manage factors that may increase your risk of complications such as:
What to Expect
Prior to Procedure
Your doctor will:
- Do a physical exam and ask you about your medical history
- Order imaging test such as ultrasound or parathyroid scan
- Have blood tests done
You should:
- Arrange to have someone drive you home from the hospital after surgery.
- Avoid eating or drinking 6-8 hours before surgery.
- Talk to your doctor about your medications, herbs, and dietary supplements. You may be asked to stop taking some medications up to one week before the procedure.
General anesthesia is used most often. It will block any pain and you will stay asleep through the surgery. In some cases, local anesthesia may be used instead. The area will be numb but you will be awake.
Description of the Procedure
There are different types of minimally invasive surgeries that may be used, such as:
A small incision will be made in the neck. A small tube with a tiny camera will be passed through the incision. The images from the camera will be sent to a TV monitors so the doctor can see the glands. Other small tools will be passed through the tube to detach and remove the gland. Once the gland has been removed, the incision will be closed with stitches.
A radioactive substance will be injected into your body. The abnormal gland will absorb the substance but the healthy glands will not. A small incision will be made in the neck and a small probe will be inserted. The probe will detect signals that are given off by the radioactive substance in the abnormal gland. This will help the doctor find the abnormal gland. Other small tools will be passed through the tube to detach and remove the gland. Once the gland has been removed, the incision will be closed with stitches.
With either surgery, if all four glands were removed, a part of one gland may be placed in a different area of the neck or in the forearm.
How Long Will It Take?
Between 30 minutes and 1-2 hours (depending on the type of surgery)
How Much Will It Hurt?
Anesthesia will prevent pain during surgery. Pain and discomfort after the procedure can be managed with medications.
Average Hospital Stay
You may need to stay in the hospital for a day or you may be able to leave the same day. Ask your doctor if this is an option for you. Your doctor may also choose to keep you longer if you have any problems.
Post-procedure Care
After your surgery, the hospital staff will:
- Observe you in the recovery room
- Check on your ability to swallow and speak
- Test your calcium levels
- Show you how to change your dressings and care for your wound
During your stay, the hospital staff will take steps to reduce your chance of infection, such as:
- Washing their hands
- Wearing gloves or masks
- Keeping your incisions covered
There are also steps you can take to reduce your chance of infection, such as:
- Washing your hands often and reminding your healthcare providers to do the same
- Reminding your healthcare providers to wear gloves or masks
- Not allowing others to touch your incision
Be sure to follow your doctor's instructions. To help your recovery at home:
- You may be given calcium supplements.
- You will be given instruction about caring for your wound. Check your wound daily for signs of infection.
- You may want to eat semi-solid foods like ice cream or oatmeal for the first few days. These types of foods will be easier to swallow.
Call Your Doctor
It is important for you to monitor your recovery after you leave the hospital. Alert your doctor to any problems right away. If any of the following occur, call your doctor:
- Tingling or numbness in the fingertips, toes, hands, or around the mouth
- Twitching or cramping of muscles
- Redness, warmth, drainage, or swelling around the area where surgery was done
- Difficulty swallowing, talking, or breathing
- Signs of infection, including fever and chills
If you think you have an emergency, call for medical help right away.