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Sorafenib Tosylate in Treating Younger Patients With Relapsed or Refractory Rhabdomyosarcoma, Wilms Tumor, Liver Cancer, or Thyroid Cancer
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This phase II trial studies how well sorafenib tosylate works in treating younger patients with relapsed or refractory rhabdomyosarcoma, Wilms tumor, liver cancer, or thyroid cancer. Sorafenib tosylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Condition | Intervention | Phase |
Childhood Hepatocellular Carcinoma Papillary Thyroid Cancer Previously Treated Childhood Rhabdomyosarcoma Recurrent Childhood Liver Cancer Recurrent Childhood Rhabdomyosarcoma Recurrent Thyroid Cancer Recurrent Wilms Tumor and Other Childhood Kidney Tumors |
Drug: sorafenib tosylate Other: pharmacological study Other: laboratory biomarker analysis |
Phase 2 |
Study Type: | Interventional |
Study Design: | Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib in Children and Young Adults With Relapsed/Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma |
- Objective response by RECIST criteria v 1.1 [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]Response rates will be calculated as the percent of evaluable patients who are responders, and confidence intervals will be constructed according to the method of Chang
- Progression-free survival according to RECIST version 1.1 [ Time Frame: From date of enrollment to the date of disease progression, date of death, date of removal of all tumor by surgery or last patient contact, whichever occurs first, assessed up to 5 years ] [ Designated as safety issue: No ]Progression-free interval (PFI) will be calculated as the date of enrollment until the end PFI date, where that date is calculated as the date of disease progression, date of death, date of removal of all tumors by surgery or last patient contact, whichever occurs first.
- Toxicity as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [ Time Frame: Up to 5 years ] [ Designated as safety issue: Yes ]
- Pharmacokinetic (PK) parameters of sorafenib tosylate [ Time Frame: At baseline, up to 12 hours and on day 15 of course 1, and prior to odd courses ] [ Designated as safety issue: No ]The PK parameters will be summarized with simple summary statistics, including means, medians, ranges, and standard deviations (if numbers and distribution permit).
- Change in VEGF and VEGFR-2 [ Time Frame: From baseline to day 15 of course 1 ] [ Designated as safety issue: No ]Descriptive statistics including mean, median, standard deviation, and range will be calculated for baseline and steady state VEGF and VEGFR-2. Changes from baseline to steady state on treatment with sorafenib will be evaluated using non-parametric paired tests if there is evidence of intra-patient correlation as assessed by Spearman's rank correlation.
- Presence of BRAF mutation or RET/PTC rearrangement [ Time Frame: At baseline ] [ Designated as safety issue: No ]Descriptive statistics including mean, median, standard deviation, and range will be calculated for baseline for patients with PTC, TG and TG antibody, and presence of BRAF mutation or RET/PTC rearrangement.
Enrollment: | 20 |
Study Start Date: | January 2012 |
Primary Completion Date: | December 2013 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Treatment (sorafenib tosylate)
Patients receive sorafenib tosylate PO BID on days 1-28. Treatment repeats every 28 days for up to 24 courses in the absence of disease progression or unacceptable toxicity.
Drug: sorafenib tosylate
Given PO
Other Names:
Other: pharmacological study
Optional correlative studies
Other Name: pharmacological studies
Other: laboratory biomarker analysis
Optional correlative studies
Detailed Description:
I. To determine the objective response rate to sorafenib tosylate (sorafenib) in children with relapsed or refractory rhabdomyosarcoma, Wilms tumor, hepatocellular carcinoma (HCC), or papillary thyroid carcinoma (PTC).
I. To further define and describe the toxicities of sorafenib administered on an oral, twice-daily continuous schedule.
II. To further characterize the pharmacokinetics of sorafenib in children with refractory cancer.
III. To estimate the progression-free survival on sorafenib for rhabdomyosarcoma, Wilms tumor, and hepatocellular carcinoma and compare to a group of patients enrolled on selected closed Phase II studies of Children Oncology Group (COG).
IV. To assess the biologic activity of sorafenib on vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor-2 (VEGFR-2) in peripheral blood samples. (Exploratory) V. To evaluate the presence of BRAF mutations and RET/PTC rearrangements in patients with PTC. (Exploratory)
OUTLINE: This is a multicenter study. Patients are stratified according to diagnosis (rhabdomyosarcoma vs Wilms tumor vs hepatocellular carcinoma vs papillary thyroid carcinoma).
Patients receive sorafenib tosylate orally (PO) twice daily (BID) on days 1-28. Treatment repeats every 28 days for up to 24 courses in the absence of disease progression or unacceptable toxicity.
Patients undergo blood sample collection at baseline and periodically during study for pharmacokinetic studies, and VEGF and VEGFR-2 analysis by ELISA. Previously collected formalin-fixed paraffin-embedded tissue samples, from patients with papillary thyroid carcinoma, are also analyzed for BRAF mutation and RET/PTC rearrangements by PCR.
After completion of study treatment, patients are followed up for up to 5 years.
Ages Eligible for Study: | 2 Years to 30 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Patients must have had histologic verification of one of the malignancies listed below at original diagnosis or at relapse:
- Rhabdomyosarcoma (RMS)
- Wilms tumor
- Hepatocellular carcinoma (HCC)
- Papillary thyroid carcinoma (PTC)
Patients must have relapsed or refractory disease (RMS, Wilms tumor, HCC, PTC)
Patients must have radiographically measurable disease; measurable disease is defined as the presence of at least one lesion on magnetic resonance imaging (MRI) or computed tomography (CT) scan that can be accurately measured with the longest diameter a minimum of 10 mm in at least one dimension (CT scan slice thickness no greater than 5 mm)
The following do not qualify as measurable disease:
- Malignant fluid collections (e.g., ascites, pleural effusions)
- Bone marrow infiltration
- Lesions only detected by nuclear medicine studies (e.g., bone, gallium, or positron emission tomography [PET] scans)
- Elevated tumor markers in plasma or cerebrospinal fluid(CSF)
- Previously radiated lesions that have not demonstrated clear progression post radiation
- Leptomeningeal lesions that do not meet the requirements noted above
- Patients with HCC must be relapsed or refractory to conventional chemotherapy
- Patients with PTC must be refractory to radioactive iodine (RAI)
- Patient's current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life
- Patients with known metastasis to the brain will be excluded from trial participation unless treated surgically or with radiotherapy and stable with no recurrent lesions for at least 3 months
- Rhabdomyosarcoma and Wilms strata: patients must be ≥ 24 months and ≤ 30 years of age at study enrollment
- Hepatocellular carcinoma (HCC): patients must be ≥ 24 months and < 18 years of age at study enrollment
- Papillary thyroid carcinoma (PTC): patients must be ≥ 24 months and ≤ 21 years of age at study enrollment
Patients must have a Lansky or Karnofsky performance status score of ≥ 50%, corresponding to ECOG categories 0, 1, or 2
- Use Karnofsky for patients > 16 years of age and Lansky for patients ≤ 16 years of age
- Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score
- Peripheral absolute neutrophil count (ANC) ≥ 1,000/μL
- Platelet count ≥ 75,000/μL (transfusion independent, defined as not receiving platelet transfusions within a 7-day period prior to enrollment)
- Hemoglobin 8.0 g/dL (may receive red blood cell[RBC] transfusions)
Creatinine clearance or radioisotope glomerular filtration rate(GFR) 70 mL/min OR a serum creatinine based on age/gender as follows:
- 0.8 mg/dL (2 to < 6 years of age)
- 1.0 mg/dL (6 to < 10 years of age)
- 1.2 mg/dL (10 to < 13 years of age)
- 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)
- 1.7 mg/dL (male) or 1.4 mg/dL (female) (≥ 16 years of age)
- Total bilirubin ≤ 1.5 times upper limit of normal (ULN) for age
- SGPT (ALT) ≤ 135 U/L (for the purpose of this study, the ULN for SGPT is 45 U/L)
- PT, PTT, and INR < 1.5 times ULN
- Normal serum lipase and amylase (per institutional normal values)
- No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% if there is clinical indication for determination
- A blood pressure (BP) ≤ the 95^th percentile for age, height, and gender; and not receiving medication for treatment of hypertension
- Patients who are pregnant or breast-feeding are not eligible
- Negative pregnancy tests must be obtained in girls who are post-menarchal
- Males or females of reproductive potential may not participate unless they have agreed to use an effective contraceptive method beginning at the signing of the informed consent until at least 30 days after the last dose of the study drug
- Patients with clinical symptoms of hepatic encephalopathy or ascites are not eligible
- Patients who have an uncontrolled infection are not eligible
- Patients with evidence of bleeding diathesis are not eligible
- Patients with known Gilbert syndrome are not eligible
- Patients who, in the opinion of the investigator, may not be able to comply with the safety-monitoring requirements of the study are not eligible
- No concurrent chemotherapy, radiation therapy, immunomodulating agents, or other investigational agents
- Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study
- Patients with solid tumors must not have received myelosuppressive chemotherapy within 3 weeks of enrollment onto this study (6 weeks if prior nitrosourea)
- At least 7 days must have elapsed since the completion of therapy with a growth factor (at least 14 days must have elapsed after receiving pegfilgrastim)
At least 7 days must have elapsed since completion of therapy with a biologic agent;
- For agents that have known adverse events occurring beyond 7 days after administration, this period prior to enrollment must be extended beyond the time during which adverse events are known to occur
- At least 3 half-lives must have elapsed since prior therapy that included a monoclonal antibody
- At least 2 weeks must have elapsed since local palliative radiotherapy (XRT) (small port); ≥ 3 months must have elapsed if prior craniospinal XRT was received, if ≥ 50% of the pelvis was irradiated, or if TBI was received; ≥ 6 weeks must have elapsed if other substantial bone marrow irradiation was given
- No evidence of active graft-vs-host disease and ≥ 2 months must have elapsed since transplant (stem cell transplant or rescue without total-body irradiation)
- For patients with papillary thyroid carcinoma (PTC) only: ≥ 3 weeks from prior radioiodine (RAI) treatment
- Patients requiring corticosteroids that have not been on a stable or decreasing dose of corticosteroid for 7 days prior to enrollment are not eligible
- Patients who are currently receiving another investigational drug are not eligible
- Patients who are currently receiving other anti-cancer agents are not eligible
- Patients who are receiving cyclosporine, tacrolimus or other agents to prevent either graft-versus-host disease post bone marrow transplant or organ rejection post transplant are not eligible for this trial
- Patients who take cytochrome P450 enzyme-inducing anti-epileptic drugs (phenytoin, carbamazepine, or phenobarbital), rifampin, grapefruit juice, or St. Johns wort will not be eligible for the trial
- Patients who have received prior treatment with sorafenib are not eligible
Patients must not be on therapeutic anti-coagulation;
- Prophylactic anticoagulation (i.e., low-dose warfarin) of venous or arterial devices is allowed provided that the requirements for prothrombin time(PT), partial thromboplastin time(PTT), and international normalized ratio(INR) are met
Please refer to this study by its ClinicalTrials.gov identifier: NCT01502410
Show 92 Study Locations
Principal Investigator: | AeRang Kim | Children's Oncology Group |
No publications provided
Responsible Party: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT01502410 History of Changes |
Other Study ID Numbers: | NCI-2012-00106, NCI-2012-00106, COG-ADVL1121, CDR0000721611, ADVL1121, ADVL1121, U10CA098543 |
Study First Received: | December 29, 2011 |
Last Updated: | June 16, 2014 |
Health Authority: | United States: Food and Drug Administration |
Additional relevant MeSH terms:
Carcinoma Carcinoma, Hepatocellular Kidney Neoplasms Liver Neoplasms Rhabdomyosarcoma Rhabdomyosarcoma, Embryonal Thyroid Diseases Thyroid Neoplasms Wilms Tumor Adenocarcinoma Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Genetic Diseases, Inborn |
Head and Neck Neoplasms Kidney Diseases Liver Diseases Myosarcoma Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Complex and Mixed Neoplasms, Connective and Soft Tissue Neoplasms, Glandular and Epithelial Neoplasms, Muscle Tissue Neoplastic Syndromes, Hereditary Sarcoma Urogenital Neoplasms Urologic Diseases |
ClinicalTrials.gov processed this record on May 05, 2015


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By Annette
from Indianapolis, IN
Comments about idville Business Card Size ID Laminate:
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Description: Star Two-Color Thermal Receipt Printer, 53/71 Column, 180mm/sec, Serial Interface, 24V, Auto Cutter, 2 Cash Drawer Drivers, with PS60-24A Power Supply. (Order Printer Cable Separately) - Color: Black
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CLERMONT, Fla. - - Jillian Stafford's two-out, two-run double in the bottom of the seventh gave the Wilmington University softball team the game one win, 5-4, over American International and the Wildcats swept a doubleheader with a 5-3 win over Mercy College in game two on the final day of the team's two-week trip to the National Training Center in Florida.
With the two wins, the Wildcats improve to 8-15 and has won four straight games to end the trip.
Heading into the bottom of the sixth, the Wildcats found themselves down 4-2 and scored a single run in the sixth and two in the seventh to finish the come from behind victory.
Stafford was the catalyst in each inning, starting the sixth and finishing it off in the seventh. Stafford doubled to lead off the sixth inning, and eventually came around to score on an Amanda Crockett doubles two batters later to make it 4-3.
With two outs and Brooke Berger on first after a walk, Kinsley Parker kept the Wildcats alive with a single, putting the winning run on base. Stafford delivered once again, smashing a double allowing Parker to race home with the winning run from first.
Stafford finished 2-for-4 in the game, while Chrisin Headley also collected two hits, including a triple. Shelby Thompson, Parker, Kristin Garvin and Crockett each added a hit for the Wildcats.
Katie Warrington picked up the win for Wilmington, pitching all seven innings while striking out nine Yellow Jackets. She gave up four runs (three earned) on nine hits to improve to 4-6.
The Wildcats carried the momentum from game one into game two, scoring all five runs in the first two innings against Mercy. The Wildcats exploded for four runs in the first, added a run in the second and rode the arm of Danielle Griffin for six innings to finish off the sweep.
The Wildcats loaded the bases in the top of the first with one out to set up the four run inning. Stafford reached on an error by the shortstop, allowing Thompson and Brooke Berger to score for the games' first runs. Garvin then reached on another error by the shortstop as Stafford and Parker came around to score two more unearned runs and take a 4-0 lead.
Parker added to the lead in the second inning with a run scoring single with two outs. With Thompson on second after reaching on a fielders' choice and Berger on first following a walk, Parker singled home Thompson to make it 5-1 and grabbing control of game two.
The Mavericks tallied two runs in the sixth, but Griffin controlled the game before handing the ball over to Warrington in the seventh for the save. Griffin gave up three runs (one earned) on five hits to improve to 3-3 on the year. Warrington pitched a scoreless seventh with two strikeouts for her second save of the year.
Thompson, Berger, Headley, Parker and Meghan Logullo all collected a hit against Mercy, all off Maverick starter Bryanna Kopczynski.
Wilmington completed its nonconference schedule and will return north to start its Central Atlantic Collegiate Conference portion of the schedule against Goldey-Beacom on March 20.


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SKU: VD_classic_StLouis_vol6
Running Time: 2 hrs 10 mins
Volume 6 of Classic St. Louis Wrestling! Relive the magic from the center of pro wrestling!
Footage from the one of the highest rated wrestling programs of all time. "Wrestling at the Chase" was the weekly TV program filmed at the historic Chase Hotel in St. Louis and promoted by Sam Muchnick. Classic footage hosted by long time St. Louis announcer, Larry Matysik.Plusnearly 30-minutes of bonus footage!
Bonus Matches


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Definition: An unbelievably intelligent yet hilarious young woman who has endless talents and entertaining characteristics. The LizZy Bear Fox is a beautiful creature with snow-white skin and multi-colored hair. Tall and graceful, shapely curved, she is a living masterpiece! Too weird to live too rare to die.
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Prices shown in USD.
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Mortal Kombat Cosplay
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Australian Prime Minister Julia Gillard talks to media in Bali, Indonesia / Firdia Lisnawati, AP
CANBERRA, Australia (AP) - Prime Minister Julia Gillard surprised Australians on Wednesday by announcing that elections will be held Sept. 14, in a country where governments have traditionally given the opposition little more than a month's notice to keep a strategic advantage.
In a speech to the National Press Gallery, Gillard said she wanted to create an environment in which voters could more easily focus on national issues by removing uncertainty around the timing.
"I can act so Australia's parliament and government serves their full three-year term, so it is clear and certain when the election will be held," Gillard said.
Opinion polls suggest the conservative opposition coalition led by Tony Abbott is likely to win convincingly.
Gillard's center-left Labor Party narrowly scraped through the last elections in 2010 to form a minority government with the support of independent legislators and a lawmaker from the minor Greens party.
Copyright 2015 The Associated Press. All
rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Read the original story: Australian PM announces Sept. 14 elections


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Alison's Common Scents
Alison's Commons Scents is an eclectic shop with organic goods. A helpful and friendly staff is waiting to help you. Also, Dave's Homebrew sells beer and wine-making supplies.
Alton Antique Center
There is something for everyone at the Alton Antique Center. Merchandise from around the world, from inexpensive to investment quality pieces, abound in this shop located on the banks of the Mississippi River. Rare one-of-a-kind items, exotic pieces, oddities, and items from Asia, Great Britain, Europe and America are available. From beautiful to whimsical, there is always something to capture the eye and the imagination at the center.
Alton Exchange
New merchandise arrives daily at this 13,000-square-foot store. From antiques to crafts to gifts and collectibles, there are unique items available to fit nearly every budget and taste. Over 100 independent dealers offer a wide variety of merchandise. Doors are open Monday through Saturday from 10 a.m. to 7 p.m. and Sunday from 12 to 5 p.m.
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Looking for quality restoration of your antique furniture? Check out Alton Landing which offers a complete restoration service. Repair work is also available for pottery, clocks and chair caning.. Canvas boat covers are also available. Open Monday - Saturday from 10 a.m. - 5 p.m.
Alton Square Mall
Anchored by JCPenney and Macy's, Alton Square Mall is the area's regional mall destination. A full-service food court, U.S. Post Office, satellite city library and Christian Science Reading Room are also featured at the mall. Hours: Sunday, noon - 6 p.m. Monday - Saturday, 10 a.m. - 9 p.m.
Alton Stained Glass
Visit this working studio to shop for hand-crafted works of art - lamps, window panes, ornaments, sun catchers, glass beads and more. From decorative items to window panes, make a purchase from the floor or have Lynne custom design a piece for you and your home. Classes are also available. Hours: Wednesday - Saturday 10 a.m. - 9 p.m. or by appointment.
Alton's Antique District
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Antiques, Etc.
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As The Crow Flies
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Beatnik's has a wide variety of unique items, including I Love Belleville items.
Belle-Clair Fairgrounds & Exposition Center
Home to the annual St. Clair County Fair, several craft shows and monthly flea markets, the complex also includes the Belle-Clair Speedway, with stock car races and demolition derbies.
Ben's Antique Mall
For over 17 years, Ben's Antique Mall has offered furniture, antiques, and Belleville items.
Ben's Craft and Floral
Ben's Craft and Floral offers a little bit of everything including craft supplies, art supplies, toys, silk flowers, beads, picture frames, and gifts. Also, a large selection of hard-to-find candy.
Biker Brother Leather Company
Whether you are just getting started in the motorcycle scene with a sport bike or an experienced rider with a chopper, Biker Brother Leather Company offers high quality road clothes and customized leather motorcycle gear. From wallets to chaps, bike seats to touring bags, there is something for everyone who desires fine quality leather items. Hours: Tuesday - Saturday, 11 a.m. - 6 p.m.
Bracelets & More
Bracelets & More features unique, custom jewelry by Sandy Schoenborn and Kathy Going. Bracelets & More also offers a wide variety of Bali silver and swarovski crystal. Also, a large selection of handbags and leather jewelry cases.
Braeutigam's Orchards
Blackberries, peaches, apples, pumpkins, tomatoes, and eggplant are the specialties at this orchard.
By Design
By Design is a unique, warm and inviting shop, offering a variety of art and wearables. All are handmade by highly skilled local and regional artists. Hand-dyed silk scarves, jewelry, fiber art, couture clothing and much more is available. Local artists also showcase their work in the in-store gallery. Hours: Tuesday - Friday, 10 a.m. - 6 p.m., Saturday, 10 a.m. - 4 p.m.
Calico Moon
Calico Moon features primitives, dry goods, rug hooking, primitive stitch, supplies, and classes.


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- Northern New York Newspapers
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CANTON Cerebral Palsy Association of the North Country and United Helpers are among the agencies serving the developmentally disabled facing a 6 percent cut in Medicaid, which could curtail services and staffing.
For Cerebral Palsy, the 6 percent reduction could mean a loss of $437,000 on top of $600,000 in cuts over the last three years, Cerebral Palsy Executive Director Doris A. Chenier said.
Whether that will translate into staff layoffs remains unknown.
Thats not our intent at this point. I think any job loss in this county is devastating, Mrs. Chenier said. In the final analysis, we just have to wait and see.
United Helpers could lose 6 percent of its $15 million budget that pays for services for the development disabled, Executive Director Stephen E. Knight said.
We dont know right now exactly what is going to happen, he said. It depends on whether its across-the-board cuts or more focused on specific programs.
United Helpers has prepared for cuts it anticipated were coming by becoming more efficient. It shaved off $174,000 in utility costs last year and did not replace some staff members who left, Mr. Knight said.
Other north country agencies affected by the funding cut proposed through the state Office for People with Developmental Disabilities include Jefferson Rehabilitation Center, the Oneida-Lewis NYSARC and St. Lawrence NYSARC.


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Our active team of librarian bloggers deliver fresh content every week. Find new arrivals, information about upcoming library programs, as well as library news and updates. Subscribe to get the blog updates sent straight to your inbox or RSS feed.
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By Cristella
Oct 2014 08
John Sandford's new book and Edge of Tomorrow on DVD are new to the collection this week.
Sep 2014 30
Cosby: His Life and Times by Mark Whitaker and Ken Burns' documentary The Roosevelts are new in nonfiction.
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New books from Bill O'Reilly and Oprah Winfrey make up our selection of new nonfiction titles.
Aug 2014 26
New fiction includes David Mitchell's (Cloud Atlas) new novel and the latest from James Patterson.


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Great Valentine's Day Gifts for your Special Bacon Lover
Spread the love with bacon.
Top 10 Bacon Quotes that AREN'T from Homer Simpson
Ok, people, we get it! You like Homer Simpson. Our post Top 10 Bacon Quotes from Homer Simpson has been our most popular post for years. But Homer isn't the only fictional character that likes bacon, people! Real people love bacon too! Here are some of the greatest non-Homer quotes that we've found out there.
The Ultimate Bacon Gift Guide for 2014
20 of the best bacony gifts available today.
Wrap Your Holiday in Bacon – Bacon Holiday Gifts
Everything you need to show how much you love bacon this holiday season.
Top 10 Bacon Themed Halloween Costumes
We all love bacon and we all love people dressed up as bacon. Check out our top 10 favorite bacon-themed costumes that are available in our store for Halloween this year!
More bacon lollipops…and other zany things
I don't really know how my husband stumbled upon these delicious-looking bacon lollipops, but here they are in all their wavy glory. I've had this type of treat before, like the Man Bait variety. They are typically maple-flavored, because apparently...Bacon Makes It Better
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If you've been thinking about a trip to Santa Barbara County's wine country, now's the time to start your planning. July 19-21, 2013 is the first annual Bacon & Barrels festival in downtown Los Olivos, in the heart of the Santa Ynez Valley, and...Denny's Baconalia is back!
Last week Naseem and I had a crazy, whirlwind experience. We were invited by the marketing and advertising team at Denny's (yes that Denny's, America's diner) to visit their headquarters is Spartanburg, South Carolina and learn about the re-launch of...Jimmy Fallon Attempts to Make Bacon Bourbon
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It's that time of year again! We have updated the Royal Bacon Society Bacon Store with all kinds of new and awesome bacon products. Here's our top 20 bacon gifts picks for the 2012 holiday gift giving season. Be sure to check out our Gifts and Stocking...Bacon Sighting in SB
Here in Santa Barbara many restaurants come and go as it is a small town with loads of restaurants, but I feel optimistic for the newest one: State & Fig. Why? Because there's bacon. I recently tried their Mac'n'cheese and their Fig Burger, both...Happy Halloween!
Wishing all you bacon lovers out there a very Happy Halloween! Here's a fantastic bacon Halloween outfit from Paul and Helen – thanks for sharing! Looks like a match made in heaven… We would also like to take this opportunity to send warm thoughts to...A Swine of Relief
Thank you, National Pig Association of the United Kingdom, for giving us all a heart attack imagining life with a bacon shortage! Insert squeal… The real blame, however, goes to our hyper crazy global media outlets that took the title of the small press release...Maple Bacon Latte
This may be old hat to a lot of you bacon maniacs – baconiacs? – but I've been wanting to try a bacon maple latte since I first heard about the Pirate Cat Radio version from Anthony Bourdain. Alas, it's not something you see on every cafe menu....Bacon 2012
Tired of all the political noise and talking heads? Bacon Bomb. I believe that says it all. Oh, and stay tuned for the Parry Gripp audio at the end. This video has it all. Thanks Megan, for bringing the...Bacon Beer, Part Two
Okay baconeers, here's something I'm really excited about. I may have mentioned before that I like heavy beers like Guinness and double black or chocolate stouts. Although you can't drink a lot of it, I love the depth of flavors and the heartiness;...-
Rasta Imposta Bacon Bunting, Brown, 3-9 Months
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text:
Owl Shirts
Does wearing owl shirts make you smarter? Do people who wear owl t-shirts know something the rest of us don't? If I wear owl tee shirts, will they keep me up at night? These questions are much deeper than we have the time to answer here. But we do know that people who wear owl shirts with the Word of God printed on them are pretty wise.
Checkout our Owl Shirts and Owl Gifts.


text:
Out of Stock
Item # NTW0058
Don't worry though, we have a lot more Men's Road Bike Shoes in stock than that.
Northwave Fighter S.B.S. Shoes $0.00
Reviews & Community
What do you think of the
Northwave Fighter S.B.S. Shoes
? Share a...
Nice entry level pairs!
- Familiarity: I've put it through the wringer
This is my first pair of cycling shoes. They work well, especially for people with wide feet. People call me a "block footer." It is hard to find shoes that would fit my wide feet and this fit well. I guess you could pay more to get better shoes but for a newbie this will do.
Buy cheap get cheap
- Familiarity: I've put it through the wringer
I'm actually using these shoes but I can't use them with tightened straps. The ratcheting top strap will not sit square in the plastic loop to which it is attached, no matter how much adjustment is attempted with the velcro. This results in an already narrow strap only being effective on the side where it is tight in the loop, making for an uncomfortably narrow tight spot. I started out using them on rollers this winter and now have over 1,000 miles on them this summer. I returned the first pair because the right one was too narrow. The second pair wasn't much better but I figured I'd give them a shot. I shouldn't have. I had them long enough now that I'm using them for recreational rides with all of the straps loose and they're good enough to avoid some wear and tear on my good shoes. Live and learn.
Nice shoe but runs small
- Familiarity: I returned this product before using it
- Fit: Runs small
Shoe looked great and had everything I wanted. The only problem is I went by the Northwave Size Chart that put me at a 42 or 42.5 (I'm a 9.5 to 10 US depending on sneaker brand). Those sizes were too small for me and I found out that I'm really a 43 in NW. Cool shoe but be sure to try them on at your LBS first or order a full size up from what the chart says.
Note to Competitive... we're cyclists.. weight is always a concern. If you guys could please post the weight for ALL your items, it would be a welcome piece of info. :)
Drew V.
First pair of cycling shoes...
- Familiarity: I've used it several times
- Fit: True to size
and I couldn't be more impressed for the price. The shoes feel solid, the stiff sole feels great, the micro adjust buckle gets the right amount of stability every time. I will definitely recommend these shoes to anyone who asks!
Backcountry Video
Northwave Fighter S.B.S. Shoes
great shoes with a defect
- Gender: Male
- Familiarity: I've used it several times
great shoes, very comfortable, but unfortunately defect with the top velcro stripe and no one could help me because i am in Bermuda?
so my problem was fix by a shoe maker but its not the same as new shoes if you know what i mean?
Happy feet
I bought these to replace some Pearl Izumi All Road shoes that I used with Shimano SPD cleats. I wanted a true road shoe but I'm on a limited budget so these fit the bill. I had tried on a pair of the Fighter shoes, no ratchet strap, in a LBS so I knew my size was a 43. My PI shoes were also a 43. I wear between a 9 and 9 1/2 shoe in US sizes. I bought the Fighter SBS over a Giro shoe that I tried on in a different LBS because the Northwave shoe was a bit roomier in the toe box. The Giro's seemed like a good shoe but they were a bit too tight for my liking. I went with some Speedplay Light Action pedals and cleats and have put about 150 miles on the shoe/cleat/pedal combo and I'm a happy rider at this point. The shoes fit and feel great.
Great Shoe
These shoes are still breaking in for me, but I'm very happy with the fit and stiffness. I'm coming off a pair of entry-level shoes that I actually cracked the sole on both cleats. These Northwave's are much much stiffer and overall fit is great. In my case, they ran a little small and I had to send the first pair back for a larger size, but realcyclist made the exchange easy. Again, these are stiff, comfortable and the closure straps/ratchet keep everything nice and snug. I even went with the blue color and love the looks of the shoe.
Im size 8 Us and Im just wondering what...
Im size 8 Us and Im just wondering what size fits me because I heard there was some rumors about the chart not being accurate. Thanks Cheers
I typically wear a 10.5 and that's what I ordered these shoes in. Unfortunately, I'm in the process of exchanging for a half size bigger. The 10.5 is snug, but I need just a little more wiggle room. My first experience with Northwave and I got the blue/white (they look so sick). everything about them feels quality from just riding around the parking lot, but I had to order a half size bigger.
Sandra Apollon
I want to buy a man cycling shoe. I live...
I want to buy a man cycling shoe. I live in Mauritius and my size is 46. Can you please help me to know how to calculate the size according to your sale.
Thanks in advance.


text: sorry it's been a while, been pretty busy but wanted to post up some new stuff that has been worked on. hopefully see some of you guys at the ABP event this weekend. 5'1"x17 3/4" x 2" for Keaton9'9" x 23" x 3 1/2" nose rider with nose tear drop swirl.6'2" x 19" x 2 3/8"


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have fun!
Oh, how I wish I still lived in the days of having spring break. It sounds like you're going to have an awesome time! Take lots of pictures and give Laurla and Luke hellos from me. I never got to Paris - get a photo of the Eiffel Tower for me! :) Have fun!
Spring Break Eve
Trip Start
Jan 04, 2006
Trip End
Apr 28, 2006
This week was spent working on our Advertising Campaign assignment worth 1/15 of our semester credits, so it was a big guy. We were to design a whole campaign (storyboard for commercial, print ad, outdoor ad, and label/bottle) for a new beer that is coming out in the UK aimed at the under 25 and involving the growing yachting hobby that Britain is seeing. It was a difficult assignment because non of us knew anything about yachting, and there are many restrictions in the UK for alcohol advertising (hence the difficulty of the assignment). But my groups beer, ultimately called Tiller's turned out really well. I liked our ideas and we had a pretty good time coming up with everything. So one more credit down, 11 more to go.
Last night some of the girls went out for another romantic dinner at Varsity. There were 6 of us, the 5 that weren't me where all leaving Friday (today) for spring break in Morroco. It was a sort of going away dinner. It was nice though after the long week of group work to just sit back and enjoy each others company. My spring break starts tomorrow morning at 6:45 when I get up and go to the airport to pick up Luke. Then we are off to London for the night before we catch our flight to paris on Sunday. We are spending Sunday through Wednesday in Paris and then going to Venice until Friday. I am beyond excited. I have heard so many good things about both places, and cannot beleive that I'm actually going to see the cities I have been dreaming about seeing for so so long. Yay!!! I'll definitely take tons of pictures and post them as soon as I can.
Then the day Luke leaves, My whole family is coming! I can't beleive they're all going to be here!!!!! I can't wait for everyone to see where I've been living. I'm so excited. I've been looking forward to the next 2 weeks for so long. It doesn't seem real that they start tomorrow....


text:
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Weopia Virtual World: the future of Online Dating?
Article Summary
More and more people these days are turning to online dating to find the love of their life. Practically everyone knows a couple who met via online dating, but conversely everyone has heard a dating disaster tale, and for every happy couple there are lots of hilarious, embarrassing or expensive tales of dating hell. Weopia could be the answer to all that; a virtual dating experience that allows you to take a romantic boat ride, watch the sunset and talk in real time to a prospective date while you sit at home in your pyjamas...
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I am new to this so I help my thread helps those newbies like myself.
This is how my day went....starting out with not having the correct tools and a member named Ray on the Caswell forum telling me that people will have what I need....
I have built one V2 Robbe SeaWolf and this is my second attempt at a RC submarine and a dream come true, a Seaview. I have been inquiring of tools required. A variable speed Moto-tool is really important and a drill press would help for the control vanes. I walked into Canadian Tire where my brother (a mechanic) who works the desk for the garage asking about the store not having a Drill Press unit for dremels but the router table was on sale. Since he works there I can save 10% and that helps a lot. He also knows what goes on sale ahead of time. Turns out it was my lucky day....
Well I have the first Moebius Seaview model and a Moto-tool from my brother and a free set of attchements on the right in the plastic holders that was going to be thrown out just today. After I spoke to my brother this after noon...the heavens are looking out for me.
10,000 to 35,000 rpm is the speed of this variable tool from Canadian Tire JobMate series. So its my lucky day.
It cut the material without melting it. I gave it a try with the cutting wheel on a piece of the sprue, as I am totally new to this.
Since thats a tool I did not have but required and cost about $100, being on a pension, I feel really lucky today. I never knew my brother had one of these. I had full speed Dremel with a flexible shaft, but its too fast for this material.
I am ordering the Merriman DVDs and Fittings Kit next week. I have seen several builds that did follow the Merriman instructions and others that explained where they deviated and why.
I had a real issue over cutting before Mr Merriman kindly and patiently talked and walked me through the reasons to do the build the way he lays it out. I want to publicly thank Mr Merriman for being so kind and for being so helpful.
I am now in-between wanting to dive into it and not having full instructions yet. I know that Mr Merriman will give me instructions on what to start with. I will detail the build as I am not experienced and maybe this will help others to be confident and give them the knowledge of what is needed and how to go about making a dream come true.


text:
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HomeProductsData Storage SystemsFAS3100 Series FAS3100 Series OverviewTech Specs Compare Contact Sales 08000 718 191 E-mail twitter facebook linkedin A new version of this product is available. Please see the FAS3200 page. Get flexibility, performance, availability, and scalability for less with the NetApp FAS3100 unified storage system. NetApp® FAS3100 series data storage systems help you handle large amounts of diverse data, with a unified platform on which you can consolidate block and file storage. With FAS3100 data management systems and the NetApp unified storage architecture, you can: Unlock the full potential of virtualized servers by enabling virtual machine mobility and offloading the work of data protection. Connect to Windows®, UNIX®, and Linux® servers and clients via standard storage protocols and interfaces. Utilize high-availability and disaster recovery solutions that include low-overhead RAID-DP® technology, Snapshot™ copies, SnapRestore® data recovery software, and SnapManager® management software. Eliminate stranded storage with NetApp's innovative thin provisioning. Make data-in-place upgrades to more powerful FAS systems, running the same Data ONTAP® operating system and using the same management tools. With its performance, efficiency, proven TCO, and flexible responsiveness to growth, the NetApp FAS3100 lets you do more for your business than you thought possible with a storage system. Learn how the FAS3100 series (PDF) can help you consolidate diverse data sets and do more with less.


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See your pink on these designs right now!
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Apply My Color
Recommended Just For You
Customer Raves & Reviews
Lovely, but small
I guess it's my own fault for not paying better attention to the size guidelines listed on the website. They look great, they're just much smaller than I anticipated. Table numbers should be larger in my opinion, but it's really not that big a deal.
Looks wise and quality wise they are excellent, as is everything from this company.
Looks Great!
I am very impressed with the amount of customization allowed on the colors and fonts on most magnet street products. I just have two small complaints about the table numbers- (1) you can't change the font of the number itself, and (2) you have to order their pre-set amount of cards. I kind of wanted to get the larger numbers, but I had to order 20 of them. I am only having 10 tables, so I went with the smaller ones and still had to order 16. But all in all I am happy and they look exactly like the proof.
Absolutely LOVE the product.. My friend recommended me to this website & said they've helped her so much.. I love the quality of the product & I had asked them 1 simple thing to change (if they could) and it was not a problem at all. The colors are EXACTLY what the samples you get look like. The quality of paper is thick & elegant.. and the printing is perfect.. I will for sure be getting the rest of my stuff for the wedding here :)
Damask Dream: the name really says it all. I initially found invites on another site and ordered them not thinking about whether or not it had any coordinating products. Of course it didn't, but I quickly found this collection and fell in love. I was able to customize everything to where I couldn't even tell that the products were from two different sites.


text:
What It Really Costs to Drive This Year
NEW YORK ( TheStreet) -- If you thought the price of health care is high, wait until you see how much it costs to drive your car or truck this year -- not the sticker price you paid to get behind the wheel, but the "driver costs" of maintenance, gas prices, insurance, deprecation and even what you pay for not having properly inflated tires.
"Many factors go into the cost calculation of owning and operating a vehicle," notes John Nielsen, AAA director of automotive engineering and repair. "This year, changes in maintenance, fuel and insurance costs resulted in the increase to just over 60 cents a mile."
AAA estimates that the annual cost of driving your car rose 1.96% from last year. In dollar terms, the average price of owning a car rose by 1.17 cents, to 60.8 cents per mile. The total amount of owning a car in the U.S. according to AAA is $9,122 annually, up from $8,900.
The AAA figures, which are based on 15,000 miles of driving each year, vary by the size of your vehicle.
For example, the annual average cost per mile of driving a small sedan is 46.4 cents, compared with 61 cents for a medium sedan and 75 cents for a large sedan. SUVs are more costly, at 77 cents per mile, while minivan drivers pay 65 cents per mile.
Here's how that breaks down, based on the type of vehicle you drive:
Small sedan: $6,967
Medium sedan: $9,151
Minivan: $9,795
Large sedan: $11,248
SUV or 4WD: $11,599
The most painful hit to the pocketbook for drivers comes from below the hood. Maintenance costs rose by 11.2%, or 4.97% for the average U.S. driver.
AAA attributes that to a hike in the cost of labor and parts and a "major" increase in extended warranty prices, thanks mostly to unusually high losses by auto insurance underwriters in the past year.
The average cost of insuring your vehicle rose $28, to $1,029, for the average sedan driver, and that's a driver considered by insurers to be "low risk, with a clean driving record."
Gas prices have risen -- that's no shock to everyday drivers -- by 14.45 cents per mile, but again it's the size of your vehicle that counts: If you're driving a smaller vehicle, the real rise at pumps to $3.48 per gallon from $3.35 won't affect you as much as if you drove an SUV, minivan or truck.
One factor affecting the annual cost of driving your car might be under the radar, but it's a big drain on the budget nonetheless: AAA says that depreciation costs, while rising less than 1%, are at $3,571 per year. AAA says that may be due to more used cars on the open market, which hurts the resale value of all cars in the U.S.


text:
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The spot for discussing TV shows and the like.
Cut Version of Salem's Lot
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TV _PG version of this would...
April 7th, 2013
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June 27th, 2013
Does Haven get better?
October 3rd, 2013
New movie of IT?
October 29th, 2013
Kingdom / Riget?
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Old European-Cut Diamond Drop Earrings
- Item No.
Sparkling Old European-cut diamonds are a hit in this spectacular pair of earrings
Key Features
Click to See Complete Item Details »
- This impeccable pair of diamond earrings features two exquisite Old European-cut diamonds
- Weighing 8.47 carats, these gems are joined by two round cut diamonds weighing 1.30 total carats
- All diamonds are set in platinum and 18K white gold
Item Details
- Stone:
This rare pair of Old European-cut diamonds, weighing 8.47 total carats, dangle from two additional white diamonds weighing 1.30 total carats in these fine drop earrings. All diamonds are set in platinum and 18K white gold. Old European-cut diamonds are approximately H color and SI2 clarity.


text:
What I need to know about Kidney Failure and How It's Treated
On this page:
- What are my kidneys and what do they do?
- What is kidney failure?
- What are the most common causes of kidney failure?
- What are the treatments for kidney failure?
- What is hemodialysis?
- What is peritoneal dialysis?
- Is dialysis a cure for kidney failure?
- What is a kidney transplant?
- What is conservative management?
- How do I decide which treatment is right for me?
- What questions should I ask my doctor?
- Eating, Diet, and Nutrition
- Points to Remember
- Hope through Research
- Pronunciation Guide
- For More Information
- Acknowledgments
What are my kidneys and what do they do?
Print Section (PDF, 214 KB)*
You have two kidneys. The kidneys are shaped like beans. Each kidney is about the size of a fist. They are located just below your ribcage, one on each side of your spine. Your kidneys filter your blood. Each kidney is made of 1 million little filters. During every minute of every day, these filters take out waste materials that can hurt you. They also take out extra fluid from your blood. The wastes and extra fluid make urine. The urine flows from your kidneys to your bladder through tubes called ureters*. The bladder stores urine until you urinate. Then, urine leaves the body through a tube called the urethra.
*See the Pronunciation Guide for tips on how to say the the words in bold type.
What is kidney failure?
Print Section (PDF, 272 KB)*
Kidney failure means your kidneys no longer filter your blood well enough to keep you healthy. Failing kidneys do a poor job of removing wastes and extra fluid from your blood. Wastes and extra fluid begin to build up. The buildup of wastes can make you sick. You may have the following symptoms:
- ankle, face, or belly swelling
- stomach sickness
- throwing up
- loss of appetite
- loss of sense of taste
- feeling tired
- weakness
- confusion
- headaches
What are the most common causes of kidney failure?
Print Section (PDF, 189 KB)*
Diabetes and high blood pressure are the most common causes of kidney failure. Other factors include heart and blood vessel disease and a family history of kidney failure. African Americans, Hispanics/Latinos, and American Indians are more likely to have kidney failure.
What are the treatments for kidney failure?
Print Section (PDF, 130 KB)*
The treatments for kidney failure are
- hemodialysis
- peritoneal dialysis
- a kidney transplant
- conservative management
What is hemodialysis?
Print Section (PDF, 232 KB)*
Hemodialysis is a treatment for kidney failure that is done in a center several times per week. Some people learn to do hemodialysis in their homes. Hemodialysis uses a machine to filter your blood when your kidneys are too sick to filter any more. With hemodialysis, your blood is filtered outside of your body. Unfiltered blood is removed from the body and flows to the dialyzer to be cleaned. Filtered blood flows back to the body. First, a dialysis nurse places two needles into your arm. A pump on the hemodialysis machine draws your blood through one of the needles into a tube. The tube takes the blood to a filter, called a dialyzer. Inside the dialyzer, your blood flows through thin fibers that are like straws. The wastes and extra fluid leave the blood through tiny holes in the fibers. Then, a different tube carries the filtered blood back to your body through the second needle. The hemodialysis machine throws out the wastes and extra fluid, just like how your body makes urine. Hemodialysis does not make the kidneys better. However, it may help you feel better by filtering your blood when your kidneys fail.
What is peritoneal dialysis?
Print Section (PDF, 265 KB)*
Peritoneal dialysis uses the lining of your belly to filter your blood inside your body. You can do peritoneal dialysis at home because it uses your body to filter. A doctor will place a soft tube called a catheter in your belly a few weeks before you start treatment. The catheter stays in your belly permanently.
The catheter lets you put a kind of salty water from a plastic bag into your belly. Then, you can move around and go about your day. While the salty water is inside your belly, it soaks up wastes and extra fluid from your body. After a few hours, you drain the salty water from your belly into a drain bag. The salty water removes wastes and extra fluid from your body. The salty water can be thrown away into a toilet or tub. Then you start over with a fresh bag of salty water. You will empty and fill your belly four to six times a day.
The salty water is always in your belly soaking up wastes and extra fluid. Peritoneal dialysis does not make the kidneys better. However, it may help you feel better by filtering your blood when your kidneys fail.
Is dialysis a cure for kidney failure?
Print Section (PDF, 125 KB)*
No. Hemodialysis and peritoneal dialysis help you feel better and live longer; however, they do not cure kidney failure. Although people with kidney failure are now living longer than ever, over the years kidney disease can cause problems such as heart disease, bone disease, arthritis, nerve damage, infertility, and malnutrition. These problems won't go away with dialysis; however, doctors now have new and better ways to prevent or treat them. You should discuss these problems and their treatments with your doctor.
What is a kidney transplant?
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A kidney transplant places a healthy kidney from another person into your body. The kidney may come from someone who has just died. Your doctor will place your name on a waiting list for a kidney. A family member or friend might be able to give you a kidney. Then you don't have to wait.
Once it is placed inside your body, the new kidney takes over filtering your blood. The damaged kidneys usually stay where they are. The new kidney is placed in the front-lower abdomen, on one side of the bladder. Your body normally attacks anything that shouldn't be there, such as bacteria. The body will think the new kidney shouldn't be there. You will take medicines called immunosuppressants to keep your body from attacking the new kidney.
Read more in the following publications from the Kidney Failure Series at www.kidney.niddk.nih.gov:
- Treatment Methods for Kidney Failure: Hemodialysis
- Home Hemodialysis
- Treatment Methods for Kidney Failure: Peritoneal Dialysis
- Treatment Methods for Kidney Failure: Transplantation
What is conservative management?
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Conservative management means your doctors take care of you without dialysis or a transplant. The doctors may give you medicines that make you feel more comfortable. You can have conservative management in your home. You may want to go to a hospice, a special place where you receive nursing care. Some people choose conservative management when dialysis or a transplant would not help them live longer or would make them suffer longer. Without dialysis or a transplant, you may live for a few weeks or several months.
How do I decide which treatment is right for me?
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If you have kidney failure, learn about the treatments and think about which one best fits you. Talk with people who are on hemodialysis or peritoneal dialysis. Ask what is good and bad about each treatment. If you make a choice and find you don't like it, talk with your doctor about trying something else. Ask your doctor about the transplant waiting list and the medicines needed after a transplant. Talk with people who have had kidney transplants and ask how it has changed their lives.
If you plan to keep working, think about which treatment choice would make working easier. If spending time with family and friends means a lot to you, ask which treatment gives you the most free time. Find out which treatment will give you the best chance to be healthy and live longer.
If you are thinking about conservative management, you may wish to speak with your family, friends, doctor, or mental health counselor as you decide.
You can take control of your care by talking with your doctor. You may need time to get used to your new treatment. Kidney failure can make your life harder. Treatments can help improve your life.
What questions should I ask my doctor?
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You may want to ask your doctor these questions:
- Which treatment for kidney failure is the best treatment choice for me? Why?
- If I'm treated at a dialysis center, can I go to the center of my choice?
- What should I look for in a dialysis center?
- Will my kidney doctor see me at dialysis?
- As a hemodialysis patient, will I be able to keep working? Can I have treatments at night? Will I be able to care for my children?
- How much should I exercise?
- Whom do I contact with problems?
- Who will be on my health care team? How can the members of my health care team help me?
- With whom can I talk about finances, sex, or family concerns?
- How/where can I talk with other people who have faced this decision?
- How long can someone like me expect to live on dialysis?
Eating, Diet, and Nutrition
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Eating healthy foods can help you keep up your energy and strength. All dialysis and transplant centers have a dietitian. The dietitian helps people with kidney failure learn about healthy food choices. You should talk with your center's dietitian to make a meal plan.
The best diet for you will depend on which kidney failure treatment you choose after talking with your doctor.
- Hemodialysis
- Limit how much liquid and water you drink. Fluid can build up in your body between hemodialysis sessions. Also, many foods contain water. The extra fluid in your body can cause swelling and high blood pressure. Extra fluid in your body makes your heart work harder.
- Limit sodium, or salt. Watch out for sodium in frozen foods and prepared meals. You can also find sodium in canned foods, hot dogs, and fast food. Sodium makes you thirsty, which makes you drink more water and other liquids than you should.
- Read more in the National Kidney Disease Education Program (NKDEP) fact sheet Sodium at www.nkdep.nih.gov.
- Limit potassium. Potassium is found in many fruits and vegetables such as potatoes, tomatoes, oranges, and bananas. Too much potassium can make your heart beat unevenly. Hemodialysis does not remove potassium from your body well.
- Read more in the NKDEP fact sheet Potassium at www.nkdep.nih.gov.
- Eat protein-rich foods such as meat, fish, and eggs. Hemodialysis removes protein from your body.
- Read more in the NKDEP fact sheet Protein at www.nkdep.nih.gov.
- Limit phosphorus. Phosphorus helps your bones, blood vessels, and muscles work.
- However, too much phosphorus can make your bones weak. Limiting phosphorus can be hard. Foods that contain phosphorus, such as meat and milk, also contain protein that you need. You should be careful to eat enough protein, yet not so much that you get too much phosphorus. You can avoid other foods that contain phosphorus, such as cola, tea, beans, and nuts.
- Read more in the NKDEP fact sheet Phosphorus at www.nkdep.nih.gov.
- Find healthy ways to add calories to your diet. Calories are found in all foods and give your body energy. Many people on hemodialysis do not have a good appetite and do not get enough calories. Vegetable oils are good sources of calories. Vegetable oils include olive oil, canola oil, and safflower oil. Use them on breads, rice, and noodles. Hard candy, sugar, honey, jam, and jelly provide calories and energy. However, if you have diabetes, speak with your doctor or dietitian before eating extra sweets.
- Read more about nutrition for people who are on hemodialysis in Eat Right to Feel Right on Hemodialysis at www.kidney.niddk.nih.gov.
- Peritoneal dialysis
- Drink as much water and other liquids as you need. If you are holding too much fluid or too little fluid, your doctor needs to know.
- Limit sodium to control your thirst and help prevent heart problems. You can use spices other than salt to flavor your food.
- You may need to eat more potassium-rich foods. Peritoneal dialysis removes potassium from your body. Talk with your doctor or dietitian about the right amount of potassium for you.
- Eat protein-rich foods. Peritoneal dialysis removes even more protein from your body than hemodialysis.
- Limit phosphorus to keep your bones strong.
- You may need to limit your calorie intake. The salty water also contains some sugar. Your body absorbs the sugar, which can cause you to gain weight.
- Kidney transplant
- Limit sodium to help prevent heart problems.
- You should be able to eat normal amounts of phosphorus and potassium. You may need to adjust the amounts if blood tests show a problem.
- Eat protein-rich foods to repair muscle breakdown and protect against infection.
- You may need to limit your calories. The medicines you take can make you gain weight.
- Conservative management
- Limit protein to prevent the buildup of wastes in your blood.
You may have other needs and limits, depending on how well your treatments work.
Points to Remember
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- Kidney failure means your kidneys no longer filter your blood well enough to keep you healthy.
- The treatments for kidney failure are
- hemodialysis
- peritoneal dialysis
- a kidney transplant
- conservative management
- Hemodialysis uses a machine to filter your blood when your kidneys are too sick to filter any more.
- Peritoneal dialysis uses the lining of your belly to filter your blood inside your body.
- A kidney transplant places a healthy kidney from another person into your body.
- Conservative management means your doctors take care of you without dialysis or a transplant. The doctors may give you medicines that make you feel more comfortable.
- All dialysis and transplant centers have a dietitian. The dietitian helps people with kidney failure learn about healthy food choices.
Hope through Research
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The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Division of Kidney, Urologic, and Hematologic Diseases, supports several programs and studies devoted to improving treatment for people with permanent kidney failure. For example, the Hypertension in Hemodialysis Patients study, funded under National Institutes of Health (NIH) clinical trial number NCT00582114, is testing the theory that treating hemodialysis patients with the blood pressure medicine lisinopril will be more effective in preventing heart enlargement when compared with treatment that uses another blood pressure medicine called atenolol, even when the two medicines achieve the same blood pressure goals.
Clinical trials are research studies involving people. Clinical trials look at safe and effective new ways to prevent, detect, or treat disease. Researchers also use clinical trials to look at other aspects of care, such as improving the quality of life for people with chronic illnesses. To learn more about clinical trials, why they matter, and how to participate, visit the NIH Clinical Research Trials and You website at www.nih.gov/health/clinicaltrials. For information about current studies, visit www.ClinicalTrials.gov.
Pronunciation Guide
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catheter (KATH-uh-tur)
dialyzer (DY-uh-ly-zuhr)
dietitian (dy-eh-TISH-uhn)
hemodialysis (HEE-moh-dy-AL-ih-siss)
immunosuppressants (IM-yoo-noh-soo-PRESS-uhntss)
peritoneal dialysis (PAIR-ih-toh-NEE-uhl) (dy-AL-ih-siss)
phosphorus (FOSS-foh-ruhss)
potassium (poh-TASS-ee-uhm)
protein (PROH-teen)
sodium (SOH-dee-uhm)
transplant (TRANZ-plant)
ureters (YOO-ruh-turz)
urethra (yoo-REE-thruh)
For More Information
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American Association of Kidney Patients
2701 North Rocky Point Drive, Suite 150
Tampa, FL 33607
Phone: 1–800–749–2257 or 813–636–8100
Fax: 813–636–8122
Email: firstname.lastname@example.com
Internet: www.aakp.org
American Kidney Fund
11921 Rockville Pike, Suite 300
Rockville, MD 20852
Phone: 1–800–638–8299
Internet: www.kidneyfund.org
American Society of Transplantation
15000 Commerce Parkway, Suite C
Mount Laurel, NJ 08054
Phone: 856–439–9986
Fax: 856–439–9982
Email: firstname.lastname@example.com
Internet: www.myast.org
Life Options
c/o Medical Education Institute, Inc.
414 D'Onofrio Drive, Suite 200
Madison, WI 53719
Phone: 1–800–468–7777 or 608–833–8033
Fax: 608–833–8366
Internet: www.kidneyschool.org
National Kidney Foundation
30 East 33rd Street
New York, NY 10016–5337
Phone: 1–800–622–9010 or 212–889–2210
Fax: 212–689–9261
Internet: www.kidney.org
United Network for Organ Sharing
P.O. Box 2484
Richmond, VA 23218
Phone: 1–888–894–6361 or 804–782–4800
Fax: 804–782–4817
Internet: www.unos.org
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Publications produced by the Clearinghouse are carefully reviewed by both NIDDK scientists and outside experts. The National Kidney and Urologic Diseases Information Clearinghouse would like to thank the following individuals for assisting with the scientific and editorial review of this publication:
Neil R. Powe, M.D., M.P.H., M.B.A.
University of California, San Francisco
Delphine Tuot, M.D.C.M., M.A.S.
University of California, San Francisco
Thank you also to Vicki McClelland, executive director, and Brian Testerman, operations manager, of the Free Medical Clinic of Northern Shenandoah Valley in Winchester, VA, for facilitating field-testing of this publication.
About the Kidney Failure Series
The NIDDK Kidney Failure Series includes booklets and fact sheets that can help the reader learn more about treatment methods for kidney failure, complications of dialysis, financial help for the treatment of kidney failure, and eating right on hemodialysis. Free single printed copies of this series can be obtained by contacting the National Kidney and Urologic Diseases Information Clearinghouse.
National Kidney Disease Education Program
3 Kidney Information Way
Bethesda, MD 20892
Phone: 1–866–4–KIDNEY (1–866–454–3639)
Fax: 301–402–8182
Email: email@example.com
Internet: www.nkdep.nih.gov
The National Kidney Disease Education Program (NKDEP) is an initiative of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services. The NKDEP aims to raise awareness of the seriousness of kidney disease, the importance of testing those at high risk, and the availability of treatment to prevent or slow kidney disease.
The U.S. Government does not endorse or favor any specific commercial product or company. Trade, proprietary, or company names appearing in this document are used only because they are considered necessary in the context of the information provided. If a product is not mentioned, the omission does not mean or imply that the product is unsatisfactory.
National Kidney and Urologic Diseases Information Clearinghouse
3 Information Way
Bethesda, MD 20892-3580
Phone: 1-800-891-5390
Fax: 703-738-4929
Email: firstname.lastname@example.com
Internet: www.kidney.niddk.nih.gov
The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Established in 1987, the Clearinghouse provides information about diseases of the kidneys and urologic system to people with kidney and urologic disorders and to their families, health care professionals, and the public. The NKUDIC answers inquiries, develops and distributes publications, and works closely with professional and patient organizations and Government agencies to coordinate resources about kidney and urologic diseases.
This publication is not copyrighted. The Clearinghouse encourages users of this publication to duplicate and distribute as many copies as desired.
This publication may contain information about medications. When prepared, this publication included the most current information available. For updates or for questions about any medications, contact the U.S. Food and Drug Administration toll-free at 1–888–INFO–FDA (1–888–463–6332) or visit www.fda.gov. Consult your health care provider for more information.
NIH Publication No. 14–7457
May 2014
Page last updated September 17, 2014


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Hornady Handgun Bullets .38 cal .357" 158 gr XTPHP 100/ct
Product Number: HO35780
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Product Restrictions This item has restrictions. Click here for more info.
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The Hornady name is synonymous with quality, evident in Hornady XTP Handgun Bullets. These hollow point bullets are designed not only for big game hunters but also law enforcement officials and self-protection. The bullets featured controlled expansion that includes six serrations dividing the bullet into six distinct and symmetrical sections.
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Top Definition
by far the best rapper ever. representin murdaland to the fullest
"wayne jones gets dome in the 500 benz on chrome, talkin on my flip phone gettin mah dick blown"
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ابريل 23, 2004
3 more definitions
this guy is a hardcore rapper who actually did get shot 3 times. Trees is missing his left pinky, has a piece of his right ear missing, and he took a bullet to the right thigh. This guy needs you to buy his CDs so he can get out of B'More.
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August 27, 2012
"Own the Bone" Provides Tools for Success to Address Growing Major Health Crisis Sibley Memorial Hospital has implemented the American Orthopaedic Association's Own the Bone™ Program. The program is aimed to better identify, evaluate and treat patients that suffer from an osteoporosis or low bone density-related fragility fracture. The program brings focus to the multi-faceted approach hospitals such as Sibley can employ to ensure these patients receive the most comprehensive care. According to the National Osteoporosis Foundation (NOF), up to 50% of all women and 25% of men over the age of 50 years will sustain fragility fractures in their remaining lifetime. The American Bone Health Prevalence Report states that more people in the United States suffer a fragility fracture each year than are diagnosed with a heart attack, stroke or breast cancer combined. Additionally, the National Committee for Quality Assurance reports, only 1 in 5 Medicare patients have received the osteoporosis care they needed after a fracture. "The implementation of Own the Bone at Sibley will greatly impact the recurrence of osteoporotic fragility fractures for our patients," explained Catherine Pulford, ANP-C, ONP-C, Clinical Coordinator, Institute of Bone and Joint Health at Sibley Memorial Hospital. "By educating fragility fracture patients in areas such as lifestyle, dietary and safety, we should greatly reduce the incidence of fragility fractures or fractures due to osteoporosis, in our patient population." Through the Own the Bone Program's Web-based quality improvement registry, which incorporates 10 measures for reducing future fractures, Sibley reduces a huge treatment gap in our community. These 10 measures help ensure Sibley patients with fragility fractures are screened and appropriately treated for low bone density or osteoporosis. By simply entering information in the Web-based data registry, results can be immediately quantified and Sibley health care providers can see how Own the Bone is positively affecting patient outcomes. About Sibley Memorial Hospital Sibley is a non-profit, full service 318 bed acute care community hospital serving the Washington, D.C. area since 1890. Sibley Memorial Hospital is a proud member of Johns Hopkins Medicine. The Sibley campus is home to an assisted living residence, Grand Oaks, and The Sibley Renaissance which houses the Sibley Center for Rehabilitation Medicine, Sibley Senior Services, skilled nursing care and a residential Alzheimer's unit. About the AOA The American Orthopaedic Association, founded in 1887, is the oldest national orthopaedic association in the world. The AOA's mission is to identify, develop, engage and recognize leadership to further the art and science of orthopaedics. For more information visit www.aoassn.org or call 847.318.7336.


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WholeFoods Magazine SourceBook: The Natural Products Directory
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President Obama Makes First Presidential Trip to Israel
Published 10:17 PM EDT Mar 20, 2013President Obama reaffirmed his commitment to Israel and its security during his trip to the Holy Land. The three day visit to the region comes amid concerns about the use of chemical weapons in Syria. Sally Kidd reports from Washington.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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"It was an age of miracles, it was an age of art, it was an age of excess, and it was an age of satire." F. Scott Fitzgerald. "Echoes of the Jazz Age" (1945)
The 1920s, also known as the "Roaring Twenties" or the "Jazz Age," was a decade of stereotypes. In fiction and on the front page, writers used labels like "rumrunner," "flapper," "red," and "radical" to make sense (or nonsense) of the time. Two of the most significant of these types were the Babbitt and the Bohemian. The Babbitt (named for the title character in Sinclair Lewis's 1922 novel) was a well-meaning but small-minded civic booster. The Bohemian was a glib and glitzy non-conformist. While Bohemians viewed Babbitts with disdain, Babbitts were sometimes intrigued but often repelled by the unconventional bohemian lifestyle. Throughout the decade, these curiously opposed types flourished and helped define society's extremes, one as the American businessman and the other as the American artist.
Changes in the American landscape reinforced these classifications. As writers and artists moved out of small towns to the rapidly expanding cities, they attacked the dullness and uniformity of the small towns they had found so confining. Their critiques became personified in the stereotype of the ever-conforming and materialistic Babbitt. Some of those who fled what they viewed as the limitations and repressions of "Main Street" inhabited the bohemian areas of the larger cities, particularly New York City's Greenwich Village. The free, wild, and colorful Village "idea" was modeled on the bohemian lifestyle of Paris at the turn of the century.
The Babbitt and the Bohemian emphasized and exaggerated the quickly changing mores and manners of American society. At one end of the spectrum was the stifling solidity of the small town, and at the other end was the wild and loose life of quite another Village. Both stereotypes resonated with Americans and were influential in literature and culture for several decades to come.
Click Image to Get a Closer Look American post card depicting Ponce de Leon Monument and Circle in Florida
Post cards from around the 1920s capture various perspectives of America's small towns and big cities.
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