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I'm missing Debian 4.0 (Etch) in the list of new distribution releases
Phoronix: The Greatest Linux Innovations Of 2007
The year is winding down and while we have a lot to look forward to next year, what were the greatest Linux innovations of this year? This year at Phoronix, we have published over 325 articles, with most of them being Linux hardware and graphics reviews, and that is in addition to over 700 original news entries. After spending much time in considering what the "best" and most substantial Linux gains over the year have been, we have comprised a list of what we believe are the greatest Linux innovations of 2007 along with our reasoning behind these decisions.
I'm missing Debian 4.0 (Etch) in the list of new distribution releases
cfs, kvm, slub, new wireless stack, new firewire stack, and (hopefully this year) lro ?The Greatest Linux Innovations Of 2007
title doesn't imply userspace innovations ;-)
i wish greg kroah-hartman's (probably have miss-spelled that, sorry) opensource driver project/initiative would be counted as one, as it actually properly kicked off this year, though. but it still has time to make a difference.
Last edited by yoshi314; 12-12-2007 at 04:04 AM.
Another great innovation: finally Yum go faster! And use DeltaRPM!
It's a important feature for all the RHEL, Fedora and Centos users.
I personally think there's some more 'innovations' that could be mentioned like:
1. WINE, it's getting very close to a 1.0 release after 15 years of development
2. Compiz Fusion, bringing the best of accelerated desktop for everyone
3. ALSA, for getting (although faulty) more than expected support for OxygenHD
4. RadeonHD driver, for letting us to have native open-source support for R5/6xx
5. Mesa, for continuing with their great support for graphics (god bless i965GM)
and... for me, the best of all
6. the Linux kernel, for bringing so many new & 'stable' features for all of us
that's my personal innovation list, at least ^_^
Amen to that!


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Studio Classic Picture-to-Complete Packsby Manuscript
Studio Classic Packs are a unique range of pen and ink drawing sets that contain ghosted pictures of animals or traditional street scenes. Simply draw over the ghosted image to create a wonderful work of art that's suitable for framing!
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Star Wars Rebels takes place between Star Wars: Episode III and IV as the Empire tightens its grip on the galaxy and a rebellion begins to form. The series, executive produced by Dave Filoni, Simon Kinberg, and Greg Weisman, is scheduled to premiere in fall 2014 as a one-hour special telecast on Disney Channel and will be followed by a series on Disney XD.
Follow Mania on Facebook and Twitter for all the latest genre news and reviews.


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General Use CO2 Incubators TC Sensor IR Sensor Refrigerated Plant Growth Glass Door
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Price Increase Effective January 1, 2015On January 1, 2015 there will be a product-wide price increase from Thermo Scientific, our manufacturer. If you have bids or quotes provided by sales reps and know that you cannot place the order before the end of the year, please be certain to contact us for an extension. All extensions must be registered before the end of the year. Expired quotes cannot be enforced retroactively. Thank you to all our loyal customers. We have enjoyed record-breaking sales in 2014 and look forward to new milestones in 2015. |


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Gibson hoping to establish comfort zone in Detroit
Twins starter looking to improve vastly on road in duel with Smyly
Twins pitcher Kyle Gibson has been dominant inside the friendly confines of Target Field. But when the right-hander travels to another team's ballpark, as he will on Friday in the first of three against Detroit, he has looked like a completely different player.
Gibson, who likely owns some of the most contrasting home-road splits in baseball this season, has gone 4-1 with a 1.54 ERA at home. In six away games, he has a 1-4 record and 7.39 ERA, with opposing batters hitting .292 with four home runs against him.
Gibson's last start against the Tigers on May 10 -- arguably his worst of the year -- saw him last just two innings while giving up six runs on seven hits at Comerica Park.
"I don't know what it is, but I'm just comfortable throwing [at Target Field]," Gibson said after throwing seven shutout innings against the Astros on Saturday. "I'm definitely comfortable throwing on the road, as well. I don't think the numbers are really in my head. I'm still making pitches on the road, but maybe not in as big of situations as I have at home."
But Twins manager Ron Gardenhire believes the actual performances have not been as ugly as the numbers imply. And if Gibson can learn how to stop the bleeding when he gets into trouble on the road, his skipper thinks the splits will begin to even out.
"He's actually thrown the ball pretty well on the road for us a couple times and just can't stay away from the one big inning," Gardenhire said last week. "We've said all along, he seems to be able to make a pitch at home and hasn't been able to figure that out yet on the road and having that one big inning where it hurts you."
The Tigers will counter on Friday with Drew Smyly.
He was originally scheduled to start on Wednesday, but his turn was skipped after Tuesday's game in Chicago was rained out and both starting pitchers for that game (Verlander for the Tigers) were pushed back to Wednesday.
Smyly started June off on the right foot, tossing six innings of two-run ball on June 6 against the Red Sox. It was the first time he made it through six innings in a start since May 13 in Baltimore, which was four starts prior. He had a 4.32 ERA in 7 may apperances (six starts).
"I think I was throwing too many good strikes," Smyly said. "It didn't really affect me. My mindset was the same -- just keep throwing strikes."
Twins: Fuld could be activated from DL soon
Center fielder Sam Fuld could be activated from the 15-day disabled list this weekend.
Fuld has been out since May 7 with a concussion but has been faring well in his rehab assignment with Double-A New Britain, homering on Tuesday. He could replace Aaron Hicks if he should head to the 15-day disabled list with a sore right shoulder.
"I wouldn't rule it out," Twins assistant general manager Rob Antony said. "I think he's getting to the point where he's having consistent days with no problems and no side effects or recurring headaches. He's swinging the bat fine. He had a leadoff home run yesterday."
Tigers: Veterans must get things in sync
Tigers bench coach Gene Lamont has seen his fair share of rough patches. Detroit, which looked like it would run away with the American League Central through the first six weeks of the season, has since fallen on tough times.
The Tigers are 7-16 in their last 23 games and have struggled to stay in sync.
"Usually when you have a long streak where you don't play well, it's hard to point to just one thing," Lamont said. "There's been guys who haven't scored, our starting pitching at times, our bullpen, our defense. It's been a combination of things. We like to think when we break out, we'll all break out together."
Lamont is confident the veteran clubhouse will get things together soon.
"I think if you have a real young team that hasn't been through something like that and has never been on a winning team, it probably makes it tougher," he said. "I think we're confident, but we have to make something happen to come out of it."
Worth noting
• The Twins are 3-2 against the Tigers and 11-10 against AL Central opponents this season. They went 8-11 against Detroit in 2013.
• Gardenhire said he has no plans to move Joe Mauer from his No. 3 spot in the lineup despite his recent struggles at the plate. Gardenhire remains optimistic Mauer will snap out of his slump, and he doesn't feel like moving him in the lineup will change anything.
Alec Shirkey is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Dependable Kuroda faces Tribe in rubber match
Carrasco returns to rotation for Indians for last of three in Bronx
Twelve pitchers have started a game this season for the Yankees, the club's highest total since 2008, when they used 13.
The only member of the Yankees' Opening Day rotation who's still healthy is Sunday's starter, Hiroki Kuroda, who will try to lead the Yankees to a series win over the Indians in the Bronx.
New York is hoping Kuroda does not have to carry that distinction for long, now that right-hander Michael Pineda seems poised to rejoin the team as early as next week.
Kuroda held the Tigers to three runs on six hits in seven innings during his last start, nearly outdueling David Price in the left-hander's first start with his new team, but Kuroda ended up not factoring in the decision.
Kuroda is 2-1 with a 3.10 ERA in three career starts against Cleveland.
Carlos Carrasco will be getting another opportunity to start for the Indians. The right-hander began the season in Cleveland's rotation, but he went 0-3 with a 6.95 ERA in four starts before being relegated to relief work.
Since then, Carrasco has turned in a 2.30 ERA to go along with a .217 opponents' average, 39 strikeouts and nine walks through 43 innings out of the bullpen.
"I just think he's in a good position to go ahead and do this," Indians manager Terry Francona said. "You try to combine letting him get in there, still winning and not burning the bullpen. I think we're probably in a situation where we can hopefully accomplish all of them."
Indians: Bourn's health, not results, most important
Through Michael Bourn's first three games with Double-A Akron, his left hamstring was feeling much better. Even though he was 0-for-10 at the plate in those games, the Indians are feeling encouraged about his progress.
"The early stage, I don't care about the hitting," Francona said on Saturday. "We want him to see pitches. To be honest with you, if he goes 8-for-10, that's not going to matter a week from now with us. There's a progression of him seeing pitches and getting comfortable.
"When he gets to us, he might be 1-for-20, but if that last couple at-bats he feels good? Good."
Bourn has been on the 15-day disabled list since July 6. He is scheduled to play with Akron again on Sunday before moving his rehab to Triple-A on Monday, when he will play a couple of games before potentially being activated.
Yankees: McCann placed on DL
Catcher Brian McCann was placed on the 7-day concussion disabled list on Saturday, one day after being struck in the mask by a foul ball.
McCann was diagnosed with a mild concussion, and the Yankees decided to place him on the DL after he visited a neurologist.
"It's not what you want, but it's what we felt was necessary to do to protect him and to make sure that he was going to be OK," Yankees manager Joe Girardi said.
Francisco Cervelli figures to be McCann's primary replacement, but the Yankees also recalled Austin Romine from Triple-A Scranton/Wilkes-Barre for catching depth.
Worth noting
• Derek Jeter took over sole possession of sixth place on Major League Baseball's all-time hits list with a sixth-inning single -- his 3,431st career hit -- during Saturday's 3-0 loss.
Jeter also owns the most hits all time for any player at his position.
• The Indians snapped a seven-game losing streak in the Bronx on Saturday, winning there for the first time since 2011.
Jamal Collier is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Daily OCD: 4/14/10 | |
Written by Mike Baehr | Filed under video, reviews, Pirus and Mezzo, Peter Bagge, Mome, Miss Lasko-Gross, Love and Rockets, Lilli Carré, Jaime Hernandez, Jacques Tardi, Gilbert Shelton, Gilbert Hernandez, Daily OCD, Blazing Combat, Best of 2009 | 14 Apr 2010 5:30 PM |
Online Commentary & Diversions:
• List: Adam McGovern of ComicCritique.Com declares Miss Lasko-Gross to be Writer/Artist of the Year ("Vividly imaginative in tricky layouts, intricate patterns and hallucinatory neverlands yet starkly perceptive of everyday details and personality, immune to art-star mythology while stockpiling stuff of legend, Lasko-Gross is capable of anything — but can't help doing right") and her A Mess of Everything the #3 Graphic Novel of the Year ("Lasko-Gross creates the least wholesome and most healthy youth memoirs you're likely to read. Tales of adolescent insight, creativity, trauma and folly for those who like to learn their lessons with minds of their own"); Gilbert Shelton's "Last Gig in Shnagrlig" from Mome Vols. 13-15 to be Strip of the Year ("With a style that seems strung from spider-webs, popping veins, worried brow-wrinkles and tangled vines and an eye for absurd posturing, both undiminished by five decades and whatever art-supplies he's been sniffing, Shelton's dystopian vaudeville is a vision you can never predict of species-wide misbehavior which remains, alas, just like you remembered it"); and Lilli Carré's "The Carnival" from Mome Vol. 14 to be Short Story of the Year ("A bittersweet, tragicfunny story of the luminous, enchanting worlds just beyond the outskirts of nowhere")
• Review: "I spent most of this week reading the new, paperback edition of Blazing Combat ... [T]he artistry on display is so mind-boggling, particularly in the case of Crandall, Heath and Severin, that it seems churlish of me to not recommend this book simply because of a few overly and obviously ironic twists. The creators clearly had a real love for this kind of material, so much so that [I] wish things had tipped slightly in their favor a bit more, and that the market had made at least a little more room for war comics when as the silver age gave way to the bronze." – Chris Mautner, Robot 6
• Review: "...I love the art, with great layouts, nice thick lines, and coloring that's somehow both rich and muted. Even when I don't like the characters or find their actions believable I still love the way everything looks. And the elliptical structure was a smart choice because it adds at least a little bit of mystery; instead of just reading to see what happens next you keep going to better understand what's already happened. I don't know if the stories were published individually anywhere, but Hallorave is basically the first book of King of the Flies, with two more on the way. I'm interested to see how closely they intersect with each other." – Garrett Martin, Shazhmmm...
• Review: "Based on a crime novel by Jean-Patrick Manchette, West Coast Blues is an existential comic by master cartoonist Jacques Tardi. It's colorless crime as only the French can do it, with despicable characters waxing philosophical on film and high-risk sex even while on the run from clumsy assassins. ... Plenty of crime stories revolve around the bizarre preoccupations of its characters and just as many are centered around the plight of the common man thrust into extraordinary circumstances. But Tardi really brings it home, offering a messed up story about messed up people who do some truly messed up things. While only 80 pages, it's a robust read. ... As compelling as this short yarn is in terms of the writing, the real draw here is Tardi. ... His style is comparable to Herge's, if not quite as clean. His characters are expressive and his architecture's pretty damn impressive. ... Big ups to Fantagraphics and editor/translator Kim Thompson for assembling a really lovely English language edition of this book." – Paul Montgomery, iFanboy
• Commentary: "You would think I'd have more to say about teaching 'Human Diastrophism,' one of my favorite comics in the classroom, but this was my fourth pass at the story and most of the classroom surprises have been played out. The greatest remaining challenge is just the problem of extracting one storyline from Gilbert Hernandez's long-running Palomar setting and fitting it into a single week of class discussion." – Marc Singer, I Am NOT the Beastmaster
• Interview: In this video, Vito Delsante talks to Jaime Hernandez at Jaime's appearance at Jim Hanley's Universe in NYC last Friday, April 9 (via ¡Journalista!)
• Interview: "'Digital vs. paper? That's a totally bogus debate,' [Peter] Bagge told Wired.com in an e-mail interview. 'There will always be both. Whichever one you want, you got it!'" Well that solves that!


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And how can one turn it ON without any control panel ?
Phoronix: AMD R600 Gallium3D Driver Patch For AF
Submitted to the mailing list over the weekend was a patch by Carl-Philip Haensch that implements support for Anisotropic Filtering (AF) in the ATI/AMD R600 Gallium3D driver...
And how can one turn it ON without any control panel ?
And what if I want to force AF for compiz cube, like I'm doing right now with fglrx ? Or what if the game does not have an option for anisotropic filtering ?
Not having a proper control panel is just a bad idea (imho).
Yet, somehow I didn't find it odd when R300/R600 split happened.
Because it was just about implementing stuff that wasn't available for R300's.
I thought that the control panel was "driconf"?
I don't know if this particular option is in there, but that's what Mesa drivers use.
Hmm, looks like the patch is only for the older chips, i.e., pre-Evergreen. But nice to have anyway.
Now it also works for Evergreen. Jerome Glisse just committed it to Git:
And the commit for older GPUs:


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State, employee unions have tentative agreements
The raise would be the first for state workers in five years, but the agreement calls for employees to pay a deductible for the first time, although insurance premiums would remain the same.
The money for the new contract will have to be included in the budget House and Senate budget writers are currently negotiating.
"After the elimination of 1,100 positions, five straight years without a cost-of-living increase, and numerous other sacrifices made by state employees, the tentative agreement is a fair deal for employees and taxpayers that will help working families make ends meet and provide important health care savings to the state," said Gov. Maggie Hassan's communications director Marc Goldberg.
House Finance Committee Chair Mary Jane Wallner, D-Concord, presented a plan that would eliminate a $50 million across-the-board reduction in personnel costs resulting in an estimated 700 layoffs and a $7 million reduction for the Health and Human Services Department.
He said the Senate would have its own proposal Wednesday morning. The House did agree Tuesday morning to an additional $430,000 reduction to the Judicial Branch budget the Senate proposed.
The Senate approved a budget of $10.7 billion, while the House's budget is $11 billion. Both the House's and Senate's plans spend approximately $2.8 billion general fund money.
Negotiators' deadline is Thursday at noon for the Senate and 4 p.m. for the House.


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Golden Apple 2015: Amber Soderling
I-70 crash near the 20 mile marker
Golden Apple 2015: Tina Jacks
Off the Beaten Path: Isabelle Turell
No bike? Not a problem!
Car crashes into southern Vigo Co. pond
Report It
March 15th sunset
Report It: January 6th Sunset
House Fire on Rio Grande Avenue
Paying tribute to our veterans
Report It Photos: April 18th
US & World
Turning off the tracking on a Smartphone
Supreme Court Gay Marriage Arguments
Photos: Baltimore Riots
Mourners Pack Freddie Gray's Funeral
Supreme Court Gay Marriage Plaintiffs
21st Century's Deadliest Earthquakes
Gay Marriage: The Decision-Makers
President Obama visits Indianapolis
Bob McDonnell sentenced to 2 years
12 DC players poised for a big 2015
Protests ripple through Buffalo
America votes
White House Correspondents' Dinner
Pics: Oprah Winfrey Auctions Belongings
Bruce Jenner through the years
Local veterans head to nation's capital
AT&T Block Party rocks Final Four
April Fools' Day Pranks Online
Sneak Peek: World's Most Beautiful Women
Most Livable Cities in the U.S.
"The Sound of Music" & the Von Trapps
Wedding Costs State-by-State
Top 10 Traveler's Choice Beaches
Hero Baker Rescues 3-Year-Old
Easter Sunday around the world
Kids take photos with Easter Bunny
2015 St. Patrick's Day Parade
New Year's Around the World
100th Anniversary of Christmas Truce
Santa visits tiny preemies in Seton NICU
Dill the Seal: A Return to the Wild
Kitten Rescued from Storm Drain
Large Dead Whale Found Beached
Giant Boa Constrictor Found
Slideshow: Semi carrying cattle accident
Stray Pit Bull Befriends Newborn Kitten
Top 10: Most expensive sporting events
NBA Playoffs Round 1 - Celtics vs. Cavs
'The Masters': Beautiful Golf
Duke wins National Championship
Final Four Coaches Show Personality
See the Final Four Celebrate Getting In
See the Great Lakes Chicago Mirage
Breathtaking Views Celebrate Earth Day
Severe Weather - April 16, 2015
Tornadoes rip through Quad Cities
Tornadoes strike Oklahoma, Arkansas
A Kayaker's View of Great Lakes Icebergs
September 11
One World Trade Center topped
President Bush: Sept. 11
President Obama visits ground zero
WH: Behind the bin Laden decision
US Celebrates at bin Laden announcement
Death of Osama bin Laden
Evansville North vs TH North
Evansville North vs TH North
1 of 53
Evansville North vs TH North
Evansville North vs TH North
Chris Essex
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Tractor involved in train accident
Car crashes into southern Vigo Co. pond
Armed robbery suspects
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Recreation Services
Recreation Services, one of the largest department in the City, provides wholesome family and individual leisure and recreation programs and services to residents. These services are provided through the City's well-maintained and operated parks system and recreation programs. The RECREATOR is a tri-annual publication that informs residents about current programs and classes that are being offered. It also lists City parks and recreational sites and the amenities offered at each.
Complete List of Facilities and Amenities (PDF)
The Parks Division operates, maintains and provides programming in over 40 parks, with provisions for use of facilities through inter-agency inter-local agreements through the Greater Boca Raton Beach & Park District, the School Board of Palm Beach County, Florida Atlantic University, and Palm Beach County. In addition to the Parks Division maintaining this vast park system, they are also responsible for the operation and maintenance of a cemetery, 2 golf courses and roadway beautification. In addition, Parks Division provides for various sensitive land sites and educational programming at the Gumbo Limbo Nature Center, including an extensive sea turtle program.
The Recreation Division provides programming for the community through three community centers, two swim centers, three oceanfront parks, athletics, skate park & shuffleboard courts, tennis facilities, summer camps, the Science Explorium, Willow Theatre, and the Mizner Park Amphitheater.
The Library (Downtown and Spanish River locations), a division of Recreation Services, is an active educational, recreational, and cultural center offering a collection of over 275,000 items including books, magazines, newspapers, compact discs, DVDs, audiobooks, CD-ROMS, games, and much more. Additional services include reference databases, inter-library loans, diverse programs for children, literacy tutoring, Internet computers, and wireless Internet access. The Spanish River Library and Community Center offers additional services including a café and a gift shop, plus a number of rooms and facilities, both inside and outside, for meetings and events. A borrower's card may be obtained free of charge upon proof of residency in the City of Boca Raton.


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What is Allure? It is a beauty expert that comes to your mailbox in the form of a magazine! You will love all the tips and advice that includes every topic you could imagine: beauty, hair, skin, makeup, beauty products, salon and spa, fashion, celebrity looks, and so much more. There are tips in this magazine for any look or style and you won't know how you survived without it! Order your Allure magazine subscription today!
Hair, Skin, and Makeup
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Beauty Products at Home and the Spa
Allure ensures that you always know the best beauty products on the market for your skin and hair. No matter what type of skin and hair you have, this magazine provides you with great tips and advice that will always help you look your best. There is a section with the editor's favorites in every issue so that you can see what even the pros say the best products are. Your cosmetic bag will be more useful than ever after purchasing a discount Allure magazine subscription.
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Find out all the beauty products that your favorite celebrities swear by and even mimic their red carpet looks. Allure will reveal all the secrets and help you get perfect hair and makeup just like your favorite celebrity. Whether you are looking for a new hot hair cut, or you are looking for the best brand of eye shadow, this magazine has you covered.
Order a subscription to your own personal beauty expert today! Subscribe to Allure magazine!


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Kansas City Chiefs Tickets
Originally located in Dallas, the franchise relocated to Missouri in 1963 and immediately earned a spot in the hearts of Kansas City residents. The Chiefs achieved instant success upon arriving in their new hometown, earning the franchise's first and only Super Bowl championship in 1970 and establishing one of the most loyal fan bases in professional sports in the process. Regardless of the opponent, Arrowhead Stadium is always packed with red-and-gold-clad fans for every game on the 2015 Chiefs schedule. From the legendary tailgates in the stadium parking lot, to the famous pregame tradition during the national anthem, to the thrilling on-field action, Chiefs games offer a game-day experience that is unmatched in the NFL. As members of the AFC West, the Chiefs are constantly hosting some of the most exciting teams in the league, and you can be there to add your voice to the raucous crowd by purchasing Chiefs tickets from the marketplace.
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Kansas City Chiefs Ticket Information
Save your place in "The Sea of Red" with a purchase of Chiefs tickets today. Football season is the most exciting time of year for Kansas City sports fans. Whether it's the action on the field or the enthusiasm in the stands, Chiefs games are packed with excitement, so begin shopping today for a vast assortment of seats inside Arrowhead Stadium. Review the 2015 Chiefs schedule above to determine which contests you would like to experience live, then complete the following instructions to finalize your purchase.
- Make your selection from the list of matchups then click the red "Tickets" tab to proceed to the following page where you'll pick out your seats.
- The following screen will display the Arrowhead Stadium seating chart alongside the complete Chiefs ticket inventory for the desired game. Adjust the price range bar, or other filter options to display the listings according to your preferences.
- When you're ready to check out, simply hit "Buy," look over the order summary, and then log in or create a new account to submit all billing and shipping information and complete the transaction. Call 1.866.848.8499 or access Live Chat for help at any time.


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The Buffalo Bison soccer team will begin defending their 2010 State Title this weekend as they take on Jackson Friday at the Kelly Walsh Soccer Complex. The Bison graduated 10 seniors from last year's squad, and this year's team will have a lot of big shoes to fill, said Coach Dick Edgcomb.
HIGH SCHOOL SPRING SPORTS - This week Sheridan media sports sat down with Sheridan high school Activities Director Don Julian who serves as the state soccer tournament director.
The 2011 state championships will be held in Sheridan county once again.
The Big Horn Equestrian center is the perfect place to host the event.
Also this spring Sheridan high school will host the big regional track meet the week before the state soccer tournament.
Noah Erickson of Sheridan came close to going all the way to the National Hoop Shoot in the Boys 10-11 age group.
After winning the local, district, and state Hoop Shoots, he represented Wyoming in the Elks Region 8 Hoop Shoot in Denver on March 12.
Jeffery Hunt of Colorado made 20/25 free throws to win 1st. Noah and Gary White of Nebraska both made 19/25. In the shoot off, White made 5/5, Noah made 4/5, so Noah ended up in 3rd place.
COWGIRLS BASKETBALL / WNIT - The Wyoming Cowgirls got 26 points from Hillary Carlson and 20 from Aubrey Vandiver in their 79-44 victory last night over Portland state.
The Cowgirls now stand at 23-8 overall and advance to the 2nd round of the tournament. They will play Monday night at home against Oklahoma state.
BRONC / LADY BRONC TRACK AND FIELD - The high school track season for the Broncs and Lady Broncs is scheduled to open Saturday at the Natrona county early bird invitational.
Riley Ryan Sheridan
Raith Durham Sheridan
Wacey Lym Evanston
Jeff Lee Evanston
Taran Brown Gillette
Blaine Shaffer Gillette
Nick Mayes Laramie
Tate Hilgenkamp Laramie
Jordan Dick Natrona
Kyle Vinich Natrona
Daveon Gibson Rock Springs
Zack Rosette Rock Springs
Josh Hunsaker Star Valley
WYOMING COWGIRLS - The Wyoming Cowgirls will host a first round game in the WNIT tonight. They host Portland state in the first round.
This will be the fourth appearance for the Cowgirls in the WNIT under head coach Joe Legerski, they made the second round in 2006, took the title in 2007 and made it to the third round last year.
We will broadcast the game live tonight on 14-10 KWYO and 95.9 FM broadcast time is at 6:30 with the tip set for 7:00.
BRONC / LADY BRONC BASKETBALL - The Bronc and Lady Bronc basketball teams got three players on the 4-A all state teams
In addition to their All-Conference selections, four Buffalo basketball players were named to the 3A All-State Team. All-State selections for the Bison boys were Aaron Tyser and Kasey Esponda. Named to the All-State Team for the Bison girls were Leah Groteluschen and Dallas Shaw. All four Bison were also named to the 3A East All-Conference Team.
Three athletes from Sheridan high school have been honored by 4-A coaches and named to the All-state teams.
Senior Kayla Woodward and Junior Steph Sessions help lead the Lady Broncs to a 24-5 record and runner-up finish at last week's state tournament.Both have been named to the 4-A girls all-state 1st team.
The Sheridan Broncs went 19-8 this past season their leading scorer was Junior Riley Ryan, Ryan was honored for his play by receiving a spot on the 4-A boys All-state 1st team.
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C de Cartier necklace
Pink gold, diamond
Pink gold, diamond
A signature C bestows pure elegance. A discreet initial of such unique purity.
18K pink gold necklace set with a brilliant-cut diamond available from 0.30 to 0.39 cts, 0.50 to 0.79 cts and 1.00 to 1.99 cts.
Length of the chain adjustable from 38 to 42 cm.
Our ambassadors are available to answer any questions or assist in making a boutique appointment.
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Kosher Soups
Cabbage and Apple Soup |
KosherEye.comby Chef Avram Wiseman Here's one of my comfort classics: A sweet and spicy cabbage and apple soup that is sure to warm you down to your toes, perfect as a first course on Thanksgiving. Ingredients: 3 oz. clarified margarine Directions: In a large heavy bottomed sauce pot melt the margarine. Add the cabbage, onions and grated apple and cook for 10 minutes, mixing frequently. Add the garlic, sugar, caraway and paprika and continue to cook. Add the chicken stock and bring to a boil. Simmer for 30 Season with salt and white pepper. Add vinegar and sour salt. Add the cooked noodles. Boil and serve very hot. May be garnished with a dollop of pareve sour cream. Notes: Yield: Serves 6 Recipes: Soups, Parve, Kosher |


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Explore - Rugs/Carpeting
Built-In Style
In Oakland, California, two designers transformed a 100-year-old barn into a (very) cozy home of their own by redefining the functionality of walls and windowsills.
written by: Miyoko Ohtakephotos by: Aya Brackett05.13.09 -
The Great Compression
In Auckland, New Zealand, architect Michael O'Sullivan and his partner Melissa Schollum braved a miniscule budget, withering looks from friends, and nasty nail-gun injuries to design and...
written by: Jeremy Hansenphotos by: Patrick Reynolds04.13.10 -
Project Runaway
Driven by the death of several appliances, a San Francisco family finds that a spanking new kitchen delivers a good dose of domestic harmony along with the excuse to execute a complete home makeover.
written by: Deborah Bishopphotos by: Leslie Williamson02.05.10 -
New Prospects
A Brooklyn architect shows what a little elbow grease, a healthy dose of naïveté, and a decade can accomplish.
written by: Jaime Gillinphotos by: Dustin Aksland08.13.11 -
Composite Index
Corporate high-flyers and admitted neat freaks Bruce Thatcher and Kirsty Leighton couldn't handle the chaos anymore. With two small boys and demanding jobs (he works in hedge funds, she&rsquo...
written by: Nicola Twilleyphotos by: Matthew Williams01.11.10 -
A Fine Vintage
At age 34, Philip M. Isaacson commissioned architect F. Frederick Bruck to design a home for him and his wife. That was 1959. Five decades later, he still lives in his ideal home—and very...
written by: Chelsea Holden Bakerphotos by: Eric Roth09.15.10 -
A Mid-Century Modern Home in Southwest Portland
Living in a state that's saturated with rain for much of the year, Oregonians rightly have an obsession with sunshine.
written by: Amara Holsteinphotos by: John Clark03.04.09 -
A Lot for a Little
Regina and Andy Rihn weren't exactly modernists when they first began their frustrating, unproductive slog through the pricey Austin, Texas, real estate market. "We just liked things...
written by: Georgina Gustinphotos by: Misty Keasler01.20.09 -
Stumptown Rock
Even before construction was complete, the Stump House was turning heads. When its green-minded future owners learned of its shining environmental résumé, they knew they'd found...
written by: Brian Libbyphotos by: John Clark03.04.09 -
Knotty by Nature
In snowy Sweden, where pine planks and the democratic design incubator Ikea reign supreme, a local architect pays homage to his patrimony, making a small, slatty home feel like a rather big deal....
written by: Grant Gibsonphotos by: Pia Ulin04.03.10 -
Massie Produced
Art object or machine for living in Architect William Massie's personal prefab project takes the mass out of mass customization to create a one-of-a-kind wonder.
written by: David Hayphotos by: Henrik Knudsen01.14.09 -
Communal Lakeside Vacation House in Ontario
On a lakeside plot outside Toronto, four friends forge a new kind of vacation house.
written by: Alex Bozikovicphotos by: Lorne Bridgman04.19.12 -
Arch Support
Layer by layer, a crumbling 18th-century flat in the middle of Barcelona finds new life at the hands of architect Benedetta Tagliabue.
written by: Suzanne Walesphotos by: Gunnar Knechtel12.29.11 -
Double Time
The last time Blake Trabulsi and Allison Orr had a party at their house in Austin, Texas, it lasted until 5 a.m. Observes Trabulsi: "People are so comfortable here, they never want to leave."
written by: Fred A. Bernsteinphotos by: Jack Thompson01.14.09 -
Graphic Carpet Ride
Like typography savants, textile cognoscenti occupy a healthy chunk of the modernist population—as they should, since woven accessories are essential for warming up a stark, streamlined...
written by: Kelsey Keith06.05.12 -
Solar Inspiration
A husband-and-wife architect team proves a house can be good for the environment—and look great too.
written by: Sydney LeBlancphotos by: Marvin Rand01.19.09 -
Ship Shape
Pieter Weijnen's brand of maritime modernism brings a touch of magic to Amsterdam's Steigereiland, where the architect built his family's home. Inhabiting one of the development...
written by: Jane Szitaphotos by: Hertha Hurnaus02.10.09 -
Glazed Old Fashioned
On a shady street just off the main drag of Melbourne, Australia's hippest inner suburb, a pair of creative types and their two kids have made a bright, cheery home by renovating an 1860s...
written by: Aaron Brittphotos by: Stephen Oxenbury07.22.10 -
A Sustainably Built Home in Rural Ontario
For this rural Ontario home, building sustainably was less about high-tech gizmos than learning to truly love the land.
written by: Alex Bozikovicphotos by: Derek Shapton10.08.12 -
Miller House in Columbus, Indiana by Eero Saarinen
Eero Saarinen's legendary Miller House opened to the public in May 2011 for the first time. Leslie Williamson gives us an intimate tour of this Columbus, Indiana, treasure.
written by: Leslie Williamsonphotos by: Leslie Williamson05.02.11


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Lawn & garden equipment for homeowners
This interactive chart will help you make a direct comparison and enable you to compare and find the right product for your needs.
Excellent ride-on mowers, built for all kinds of garden work. And with our wide range of accessories there's work all year round.
It is the finishing touch that makes a garden perfect. Our efficient and easy handling trimmers do the job.
A servicing dealer has both the experience and the knowledge to know the outdoor trade inside out.


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Boost your school pride (and your cool factor!) with American made Nocona College Boots. Choose authentic, premium quality western boots made by legendary boot manufacturer, Nocona Boots. These Women's Nocona Boots are officially licensed and designed with the Alabama Crimson Tide logo to show your alumni support to the world. The Nocona University of Alabama cowboy boot features a tan Ponteggio leather foot under an 11" matching leather shaft. Official University of Alabama lasered school logo accents. Natural leather piping. Cushion insole offers comfort from the first step. Single stitched welt. Easy-wearing low 1 1/2" cowboy heel with rubber grip surface. Snip toe.
Please note, Ponteggio leather may arrive darker than shown. To achieve desired appearance quickly, work the leather in hand.


text: [First pages of this letter missing] ... as they charged the enemy. Charge after charge, yell after yell, the scene was awfully [illegible] and terrific. We drove the enemy about four miles, step by step to contrasting weary inch of ground till [illegible] fall, when they threw down their arms and fled in the wildest confusion. Now was our time, but oh, night closes the scene. Oh, could we like good old Joshua have commanded the sun to stand still for six hours, we would have killed, captured and [illegible] the combined army of Pope Burnside and McClellan. But we could not, night closed the scene, and we lay down on the bloody field to rest our weary frames, which after the excitement was over, were completely


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Daily OCD: 1/6/10 | |
Written by Mike Baehr | Filed under The Comics Journal, Supermen, Sergio Ponchione, Robert Williams, Robert Goodin, reviews, Popeye, Peanuts, Mort Walker, Michael Kupperman, Kim Deitch, Kevin Huizenga, Johnny Ryan, Jerry Dumas, Jacques Tardi, Humbug, Gilbert Hernandez, From Wonderland with Love, EC Segar, Dash Shaw, Daniel Clowes, Charles M Schulz, Carol Tyler, Carol Swain, Best of 2009 | 6 Jan 2010 3:27 PM |
By the way, multiple belated hat tips to Robot 6, whose roundups of end-of-year links have been invaluable to the last few installments of Online Commentary & Diversions. On with the links:
• List: Publishers Weekly announced the results of their 2009 Comics Week Critic's Poll; among the top vote-getters are You'll Never Know, Book 1: A Good and Decent Man by C. Tyler ("I love this autobiographical family story as much for the way Tyler weaves between her own life and her father's, as for its painterly, illustrative panoramas of suburban neighborhoods and army scenes." – Sasha Watson) and Tales Designed to Thrizzle Vol. 1 by Michael Kupperman ("Milk and other liquids may come out your nose as you read one of the funniest comics ever put to paper. Kupperman's droll absurdism is matched by a stiff, woodcut-like art style that underplays the sometimes outre concepts. A comedy diamond." – Heidi MacDonald). Humbug by Harvey Kurtzman et al, Low Moon by Jason, Luba by Gilbert Hernandez, Supermen!: The First Wave Of Comic Book Heroes 1936-1941, West Coast Blues Jean-Patrick Manchette and Jacques Tardi, and You Are There by Jacques Tardi and Jean-Claude Forest all received single votes in the poll
• List: At comiXology, Tucker Stone counts down his top 25 Best Comics of 2009, with Grotesque #3 by Sergio Ponchione at #23 ("...every once in a while, I get a reminder how vast the world of comics really is. Grotesque — European, unusual, brilliant — was one of those, an experimental passport to another universe"), Ganges #3 by Kevin Huizenga at #7 ("...Ganges captured the thing that all of us spend a lifetime doing — thinking — and turned it into something deserving of examination") and, in the top spot, Prison Pit: Book 1 by Johnny Ryan ("Aggro, obscene, hilarious, compulsive: Prison Pit. It wasn't just the greatest comic of the year, it was one of those comics that operated like the end result of a math equation, a definitive answer to the question of what comics are, and what they should be...")
• List: Johnny Bacardi's Personal Best of the Decade includes Eightball #22 by Daniel Clowes
• Review: "Each [panel] almost vibrates with the frenetic, desperate energy of the characters as they try to pull off their cons. That energy explodes in the final pages, as the story comes to a dramatic but ambiguous conclusion. In the end, the work offers an homage to B-movies while standing out as a graphic novel. The Troublemakers will please long-term Hernandez fans. It also should serve as a good introduction to newcomers looking to jump into the Love and Rockets universe." – Publishers Weekly
• Review: "...Giraffes [in My Hair], a collection of anecdotes from Bruce Paley's teens and twenties on America's countercultural fringe, is a breezy read. ... Swain's art rarely calls attention to or gets in the way of itself, and in that it meshes seamlessly with Paley's deadpan 'here's what happened' narrative style, his reluctance to overstate or oversell the import of the anecdote reminiscent of Harvey Pekar's." – Sean T. Collins
• Review: "...[The Comics Journal] has reached issue 300 and is celebrating with a fascinating collection of creator-chats as industry tyros and giants come together to interview, share, bitch and generally shoot the breeze about graphic narrative: a tactic that makes this the most compelling read of the year for anyone truly interested in what we all do and why." – Win Wiacek, Now Read This!
• Review: "Fantagraphics Books continues its series devoted to chronologically packaging [Peanuts] and has not missed a step along the way. ... I'm pleased to inform that the latest edition, the twelfth in the series, is as lovingly curated as the first... [I]t is nice to know that one of the form's greatest achievements is being held up as the accomplishment it really is." – Dw. Dunphy, Popdose
• Review: "It's clear from editor/publisher Steffen P. Maarup's survey [From Wonderland with Love: Danish Comics in the Third Millennium] that, contradicting Horatio's famous line in Shakespeare's Hamlet, there is nothing 'rotten' about the state of comics in Denmark today. If anything, it's nurturing a number of major talents as well as sprouting exciting new shoots." – Paul Gravett (via Robot 6)
• Review: "[In Sam's Strip] Walker and Dumas clearly take pleasure in working in callbacks to classic comic strips... [and] many of the metatextual gags are funny and fun. ... Dumas's drawings of classic comic-strip characters are excellent... The result is a frustrating, compelling curiosity: the soul of an underground comic trapped in the mortal coil of a Hi and Lois." – Shaenon Garrity, The Comics Journal
• Plugs: At Comics Alliance, Douglas Wolk's recommended comics of the week include The Troublemakers by Gilbert Hernandez ("It's crazy, vivid, grindhouse-y stuff") and The Unclothed Man in the 35th Century A.D. by Dash Shaw ("intriguing")
• Plugs: The Gosh! Comics Blog also highlights The Troublemakers by Gilbert Hernandez and The Unclothed Man in the 35th Century A.D. by Dash Shaw among the week's noteworthy releases
• Plug: Rob Orange of Seduced by the New features Conceptual Realism: In the Service of the Hypothetical by Robert Williams
• Plug: Illustrator Joanna Barnum spotlights Nell Brinkley as an inspiration
• Plug: Mark Langshaw of Digital Spy takes note of the upcoming Kim Deitch book The Search for Smilin' Ed
• Analysis: Robert Boyd examines Popeye's propensity for cross-dressing, with evidence from Popeye Vol. 4 (via Jeet Heer)
• Coming Attractions: Wayno, whose work appears in the forthcoming Newave: The Underground Mini Comix of the 1980s, talks about the book and the (announcement!) upcoming exhibit at Fantagraphics Bookstore & Gallery
• Events: Star Clipper is sponsoring a screening of Ghost World at Schlafly Bottleworks in St. Louis tonight — oh jeez, in like half an hour! — and copies of the graphic novel and other Clowes books will be on sale
• Things to see: Follow your nose to a new Kevin Huizenga-drawn Amazing Facts and Beyond with Leon Beyond strip
• Things to see: Finished pages from Robert Goodin's 19-page story "The Spritual Crisis of Carl Jung"


text: You are posting a comment about... Movies Based on Books In our most recent survey we asked you if you like movies based on books. Here are the results: 55% - Yes 39% - It depends on the movie/book 5% - No Be sure to participate in our newest poll and let us know what you think. |


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April 26, 2014 - 02:00 pm to 04:00 pm
Ages 13- 19
In this exciting new program, teens can explore creative fields and industries with working artists and professionals before putting their own skills to the test with a hands-on project. This month we'll explore the world of illustration.
$5 Art Museum Members, $10 non-members. Reservations required. Please call (513) 721.ARTS (2787) to purchase tickets.


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Gallery: London's 2012 Olympic Park Opens to the Public this Week After...
The Olympic Park was built on former industrial brownfields, which had to be cleaned up before the games.
Hosting the Olympics is a massive undertaking for the host city. In 2006, London demolished more than 200 buildings to make room for what would eventually become the Olympic Park. When those buildings were demolished, an impressive 98 percent of the materials were reused and recycled in the construction of the Olympic Park and elsewhere. The Olympic Park was built on former industrial brownfields, which had to be cleaned up before the games. About 1.4 million cubic meters of contaminated soil was excavated from the site, and five enormous soil washing machines were brought in to wash the soil and filter out oil, tar and heavy metals.
In addition to the Aquatics Centre, the Olympic Park also includes the Wilkinson Eyre Architects-designed Basketball Arena, a large 12,000-seat temporary structure that will be taken apart and recycled once the games have ended. The other major indoor facility at the Olympic Park is the Copper Box, which will be used for handball and fencing.
After the 2012 Summer Olympics are over, the Olympic Park will again be transformed. In 2013, the roughly 500-acre Park in East London will reopen as Queen Elizabeth Olympic Park. The 377-foot ArcelorMittal Orbit will still tower over the park, and the 80,000-seat Olympic stadium will be downsized to a permanent stadium that will seat 25,000 people.
Photos via London 2012
1 Comment
tootsabird July 25, 2012 at 11:46 am
Recycled building elements are vital to us. Good going with that. Let's hope the buildings get used to the max. I'll never forget visiting Expo '67 site in Montreal and seeing it abandoned. What's the point of all that show and then wasting the fabulous buildings?
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The final thesis is a comprehensive and highly independent task where the student has to demonstrate the ability to analyse the given problem from theoretical and practical aspects, devise a solution using the knowledge acquired in multiple courses and literature, implement the solution, write the documentation and instructions for use and/or for further work, to present his or her work in written and oral form. The accent is given on demonstration of ability in all these aspects rather than to force students to pursue some work intensive repetitive activities in order to fully complete a product.
Enrollment: Passed: Software Design Project
Mandatory - module Computer Engineering


text: With over 5,400 industry professionals, BuildingsNY & GreenBuildingsNY is the largest buildings event for the New York metro region. From June 16-17, 2010 at the Jacob K. Javits Center, in NYC, you will have the opportunity to see the latest in energy-efficient, cost-saving 'green' solutions for the design, construction, restoration and renovation for every type of building including Retail, Hotels, Museums, Stadiums/Arenas, Indoor/Outdoor Parking Facilities, Warehouses, Spas, Residential, Restaurants, Nightclubs, Themed Environments, Schools, Healthcare, Places of Worship and more! At Booth #G541, Bulbtronics will be exhibiting our green lighting products including the latest in LED technology for all industries and applications, energy-efficient compact fluorescents, and RecyclePak®, a cost-efficient recycling solution for bulbs and batteries. Pick up our new LED Lighting Guide available on a convenient mini-CD - yours FREE! You'll also have the opportunity to engage in some fun social networking activities and have the chance to win prizes! REGISTER TODAY!


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Cafeteria & Coffee Shops
HCMC's Inspirations Cafe
Location: Orange Building, Level 3
Listen to today's menu at 612-873-2055.
Monday - Sunday: 6:30AM - 6:30PM
The hospital cafeteria is open to employees and visitors seven days a week. The managers, chefs, and servers of Inspirations Café strive to provide meals that are convenient, healthy, and delicious. Our goal is to provide nutritious meals that sustain our customers — be they hospital visitors or staff— with the energy to fuel them throughout the day. You can choose from meal entrees, grilled foods, pizza, soups, sandwich items, a salad bar, fresh bakery items, soft-serve frozen yogurt, cappuccino, a potato, deli, or taco bar, and more.
Dunn Bros Coffee Shops
Our coffee shops sell gourmet coffee and specialty drinks, fresh bakery and pastries, fresh-made sandwiches, soups and specialty salads.
Red Building Level 1 Lobby
Red Building entrances: 730 South 8th Street and 717 South 7th Street
Open Monday through Friday, 6AM - 10PM
Saturday and Sunday, 8AM - 2PM
Blue Building Level 1 Lobby
Blue Building entrance: 900 South 8th Street
Open Monday through Friday, 6:30AM to 4PM
Purple Building Level 2 Skyway
Purple Building entrances: 716 South 7th Street and 717 South 6th Street
Open Monday through Friday, 6:30AM to 4PM
Center for Senior Care


text: Sakib Moghal You really should try to get some facts right if you want to be taken seriously. Inflating figures, missing out vital facts such as the role of the Christian phalangists. One thing you did get right, the Palestinian movement is flawed. The main one being, that it refuses to accept the existance of the State of Israel. THIS is the main obstacle to the palestinian Arabs getting a state. Every thing else follows on from this one single fact!


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Newbie Question: Light Sensers
So this is a matter of dispute between a friend and myself.
The trick of lowering you bike sideways when you stop at a stop light, does it make the light change faster? Is there a sensor that is able to register the bike and therefore change the light? I know this question sounds ridiculous, but I need an answer to clear this up. Also if anyone could provide proof, one way or the other. Thanks a lot! -TimmyTwoPedal |
I don't know that it changes faster, but it can help the sensor "see" that a vehicle is present. At work we have a gate that lowers automatically at night. I have to lean my bike over on its side in order to trip the sensor that raises the gate. No doubt the same dynamic is at work with traffic signals.
Dang, I'm actually trying to disprove my friend's theory.
What mechanism does you work use for its gate? Is it really a metal detector underneath? Admitted I know very little about streetlights so I imagine that they use a variety of sensors, the question is if this one is being by them in any cases. Do you know if the sensor you have at your work (I'm guessing a commercial version) is similar enough (or the same as) to a public street sensor? -TimmyTwoPedal P.S. I know that there used to be light sensors on the top of specific streets for Emergency vehicles and that these have been replaced in some states by a UV sensor that Emergency vehicles lights trigger; But these are specific to certain routes and usually on busier roads. Last edited by TimmyTwoPedal; 04-27-2010 at 11:38 AM. Reason: Added P.S. |
I think the street sensors use electro-magnetic induction to detect the presence of a large object nearby. I assume the gate here at work uses the same method -- there is no pressure cable on top of the pavement, and no photo-sensor along side it. On the street, you sometimes see painted symbols of a bike over the induction loops, to mark the "sweet spot" for bikes. Usually all you need to do is position your bike at that spot. You should be able to trip most of the lights by locating the induction loop cable (you'll see where the cut in the pavement was sealed), and stopping your bike over the loop. This should work even on signals that don't have the bike symbol marking, but not always. In those cases leaning your bike over should provide a larger target. I've heard that it's not just positioning that counts, but the duration of the stop. A short stop over the sensor shouldn't trigger the signal, you need to stay there for a bit. |
Sometimes in front of a stop light you will see that a thin, circular or diamond-shaped cut was made in the pavement and then filled in with new asphalt. There is a loop of wire under there that detects when a large metal object is over it - I presume it uses magnetic induction.
Those loops are calibrated for cars and often bikes will not trip them. Sometimes leaning your bike over closer to the ground will get more metal closer to the loop and will sometimes cause it to register that you're there. Now if you have some fancy carbon fiber bike you're probably out of luck regardless of how far you lean your bike over to one side. |
Say Cheese!
Many of the sensors in Beaverton are actually tied to a camera. I've found that to trip those on wet nights is to locate the camera, and shine my helmet light directly at it.
They work when they detect a large change in the values of the pixels in the sensitive areas. So, if you don't see a diamond, or circular cut, and you know that the intersection is not set by a timer only, look for those cameras. |
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Effective Use of Mild Acting Herbs V. Dang Shen (Codonopsis)
by Subhuti Dharmananda
Codonopsis refers to the roots of Codonopsis pilosula, recognized as a common substitute for ginseng (Panax ginseng).The botanical name derives from the plant's bell-like flowers and the hairy character of its young growing parts.The Chinese name given to this herb, Dang Shen, indicates that it was considered to be a ginseng-like plant (ginseng is renshen) from the Shan Dang region of Shan Xi Province, which had been the principal source for ginseng in ancient times.Codonopsis didn't appear in any of the herbals prior to the Qing Dynasty; it was first mentioned in the Ben Cao Cong Xin (by Wu Yiluo; 1751) and in the Bencao Gangmu Shiyi (by Zhao Xuemin 1765).Though codonopsis originates in east Asia and is found growing wild, nearly all the modern supply comes from cultivation.The roots are harvested in autumn after three years growth for use as a medicinal; they have a mild, sweet taste and are used in some Chinese food therapy recipes; for example, chicken soup may be prepared with codonopsis, astragalus, lotus seed, lycium fruit, and other mild herbs to make a good tasting qi tonic.The root of the related plant Codonopsis lanceolata is seasoned with salt and pepper, and used as a food in
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Veno-occlusive disease (VOD) is an inflammatory condition caused by the high-dose chemotherapy used to condition patients before stem cell transplants. The therapy damages blood vessels and cells in the liver and leads to pain, build up of fluid in the body, and abnormal liver function.
Defibrotide is an investigational drug being studied as a possible treatment for VOD. Defibrotide has been used in the past to treat kidney loss after kidney transplantation, to lower blood vessel inflammation, and to treat VOD in blood stem cell transplant patients. These studies show that defibrotide cures severe VOD in about 40 percent of patients. The purpose of this study is to evaluate the safety and effectiveness of defibrotide as a possible treatment for VOD.
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
For more information and to inquire about eligibility for this study, please contact Dr. Nancy A. Kernan at 212-639-7250.


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Chelsea's BadgesFoursquareBeantown
You've strolled along the Charles, belted "Sweet Caroline" with the best of them, hit every stop on the Freedom Trail and even taken an ironic Duck Tour or two. Paul Revere would be proud (Duck Tours aside).
Chelsea unlocked the Beantown badgeMarch 24, 2012
Download Foursquare for your smart phone and start exploring the world around you!


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No minimum purchase. First time buyers only. Click here to activate.
Save 10% with Auto Delivery on this and all future orders of this item with our Simplify Life automatic delivery program! Click here for details.
Designed for simplicity, the RC Pet Adjustable Kitty Breakaway Collar is the collar your cat needs. It's a great alternative for cats that just can't seem to keep their collars on- the buckle is designed to release should the collar become snagged.
One size fits all! You can easily adjust the collar to the proper fit around the cat's neck and clip. Simply squeeze the side release buckle to unclip. RC Pet Adjustable Kitty Breakaway Collar is elastic sewn for extra comfort. Available in some cool and colorful patterns!
Review Rating: 4.5
Country of Origin: Canada
Manufacturer: RC Pet Products
The reviews below are presented for informational purposes only and are not intended as an endorsement of any product. The information is not intended to be a substitute for visits to your local veterinarian. Instead, these testimonials offer the reader information and opinions written by pet owners and/or veterinarians concerning animal health and products that they have used.
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Seems like a winner so far
By Apartment Cat Owner
from Los Angeles, CA
About Me Long-time Pet Owner
Comments about RC Pet Products Kitty Breakaway Collars:
I got two designs: the tropical fish and the love birds, both of which are adorable and vibrantly colored. They seem very durable. The only thing I don't like, as other reviewers have mentioned, is the thick plastic tag ring, which I couldn't easily attach tags to. I'm only using one for now because I was able to add a small metal ring to use instead of the one included. I couldn't figure out how to remove/break off the plastic one so at least it seems pretty durable for those who do prefer to use it.
Comment on this review
nice looks great
By cat dog rat rabbit lover
from INDANA
About Me New Owner
Great i got the pirate one for my male cat
Love this collar
By Jenni
from Baton Rouge, LA
I love this cat collar. My cat was always removing his collar. This collar is wider and stays on.
Size may matter
By Interspecies Parent
from Eugene, OR
It is a good, sturdy adjustable collar. My cat wears the reflective one even though he only goes out on a harness and leash (not a good idea to use a leash with breakaway collars). It does a good job of reflecting light so he is more findable if we get separated in an emergency, but I would not depend on it to protect him from cars. It is wide so his hair doesn't hide it. It does seem a little too stiff and wide for a cat, but maybe it will loosen up in time. The loop is hard plastic (which may get brittle) and is really big (which cats tend to get caught on things). I attached a smaller metal ring instead.
keeps kitty safe!
By vanessa
from indianapolis,in
My cats are indoor/outdoor cats that like to go out in the evenings after we get home from work. I feel much better knowing that Harley has a reflective collar - I plan on buying another one for my other cat.
Black cat not invisible at night
By Helkat
from Mountain View, CA
Boo is a completely black, outdoor 11 year old cat whose previous collars (with elastic) were immediately left on fences. This collar releases when needed. I bought the reflective version for obvious reasons. By the way, his vet thought it was brilliant to have the reflective version.
(1 of 1 customers found this review helpful)
Kitty Collar
By Jojo
from Flowery Branch, GA
I actually ordered 4 collars with different designs. They work all great but actually one of them was not staying attach to Puffy my smallest cat. I am not sure if it's a defect one because the other one works all great and stay on.The designs are really nice also and my cats look great!


text:
- Hikaru Koto
- Set of 149 pictures
- Download full set in zip
- Add to favorites
Hikaru Koto has her own web sites and webcams with live set ups that she and her other Asian babe friends run. They are into all kinds of stuff especially mastrubation. They can really find some odd things to masturbate with too. That must be what is making their sites so popular. You never know what they are going to be putting in their hairy pussies next! They certainnly are fun to watch - thats for sure!
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@ Idols69.com - High definition AV Idol website...


text:
O's, Red Sox set to begin high-stakes division battle
Feldman takes on Dempster as both teams eye postseason berths
The Orioles are still in the mix for an American League Wild Card spot. If they're going to gain ground in that race over the next week, they're going to have to earn it.
After Monday's off-day, Baltimore will begin a stretch of 13 consecutive games to end the season. The next seven come on the road against AL East rivals Boston and Tampa Bay, both of which would be playoff-bound if the postseason began now. That rough road for the Orioles begins Tuesday night at Fenway Park, where Scott Feldman will square off against Ryan Dempster and the Red Sox.
"It's big," O's reliever Tommy Hunter said of his club winning two of three against the Blue Jays over the weekend. "It takes us into that Boston series with a series victory. We have quite a task ahead of us. We're looking forward to it."
While Baltimore rebounded after dropping three of four games vs. New York by winning its series in Toronto, Boston has rolled through just about everyone in its path lately.
The Red Sox finished off a three-game sweep of the Yankees on Sunday, delivering a significant blow to their rival's playoff hopes. Now, they will look to do the same to another divisional foe, all while moving another step closer to clinching a division title. With a victory and an Indians loss to the Royals tonight, the Sox would clinch at least a Wild Card berth -- the first club to claim a spot in the postseason.
Overall, Boston has won five of its past six games, 10 of its last 12 and 17 of 21. That streak has put the Sox in an ideal position down the stretch, with a magic number of four to clinch the AL East entering play Monday.
The Red Sox will send Dempster to the mound hoping he'll pitch deep into the game, which has been an issue for him recently. The 36-year-old right-hander has completed seven innings only once since June 14, but he pitched effectively Wednesday against the Rays, offsetting five walks with seven strikeouts and allowing only one run on four hits over five innings.
Feldman, meanwhile, hasn't had any trouble pitching deep into games, as he's gone seven or more innings in three consecutive starts. The right-hander followed up a shutout against the White Sox on Sept. 6 by allowing three runs over 7 2/3 innings Wednesday against the Yankees, though he didn't receive a decision in that outing.
"I think that when you know where the ball is going, you can get some quicker outs that way," Feldman said Wednesday. "You can stay in the game a little longer."
Orioles: Hitting with RISP proving problematic
Baltimore left Toronto on Sunday with a 3-1 victory and a series win, but also with familiar questions about the club's recent inability to hit with runners in scoring position. The Orioles went 1-for-8 in those situations Sunday, making them 37-for-171 (.216) over their last 22 games. Baltimore has gone 10-12 during that stretch.
"It's not like all year we've been bad. Comparatively speaking in the Major Leagues, we're close to the top," Orioles manager Buck Showalter said. "But I know it's, 'What have you done for me lately?' I, as a manager, can't live in that world. You will lose guys in a heartbeat in that 'What have you done for me lately' world. It doesn't mean there's not a sense of urgency with it."
Red Sox: Farrell taking advantage of sizable division lead
With his club having opened up a comfortable lead in the AL East for the time being, Red Sox manager John Farrell said he plans to use the final two weeks of the season to make sure his players are healthy and well-rested entering the postseason.
Most recently, that meant holding Shane Victorino out of the starting lineup on Sunday for the second time in four games. Even with an off-day on Monday and two more next week, Farrell will still likely mix-and-match his lineups down stretch to get extra rest days for his players.
"We've got a number of guys that are dealing with some minor things that they're banged up with," Farrell said prior to Sunday's victory. "We'll try to take advantage not only of getting another left-hander in the lineup [Sunday] against [Yankees starter Ivan] Nova, but [Monday] being an off-day, we may look at some things Tuesday and beyond to try to get some guys off their feet a little bit."
Worth noting
• Sixteen of the Orioles' last 21 games have been decided by two or fewer runs (6-10 record), including eight one-run games (2-6).
• The Red Sox have now won at least 90 games in nine of the last 12 seasons, and in 11 of 16 years since 1998. During that stretch, only the Yankees have more 90-win seasons (13).
• The Orioles have gone 16-28 this season in one-run games, but own a 19-9 record in two-run contests. The Red Sox, meanwhile, are 21-18 in one-run games while going 14-13 in two-run affairs.
• Orioles shortstop J.J. Hardy is just 3-for-32 (.094) with seven strikeouts in his career against Dempster.
• Red Sox first baseman Mike Napoli is 11-for-26 (.423) with two home runs and six RBIs lifetime against Feldman.
Adam Berry is a reporter for MLB.com. Follow him on Twitter at @adamdberry. This story was not subject to the approval of Major League Baseball or its clubs.


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It must be nice to be governor
It appears that Gov. Shumlin, a millionaire, has received another sweetheart deal regarding the purchase of the Dodge farm (Times Argus, May 22, After sale to governor: regrets) which borders his property. According to The Times Argus, the governor purchased a distressed home appraised at $233,700 for less than $58,000. According to the article, Mr. Dodge did not have an attorney, was a high school dropout, did not know what other options he may have had and, according to a friend, Mr. Dodge did not have the cognitive skills to advocate or even understand the basic elements of the deal.
The governor was also effective in convincing the East Montpelier town to reduce the appraised value of the Dodge home from $233,700 to $140,000. The back taxes owed by Mr. Dodge, $17,000 from 2009, were based on $233,700, not the appraised value of $140,000, which the governor was able to receive. Because of Mr. Dodges condition he may have been unaware that he could have appealed his property taxes being too high. Instead of helping Mr. Dodge, the governor took advantage of his situation to enrich his holdings.
Another sweetheart deal: The governor was able to purchase for $35,000 a 32-acre parcel next to the Dodge farm valued by the town listers at $147,000 in 2012. Tell me where I can as a native Vermonter purchase property as the governor has here, making over $200,000. In the poem Mending Wall by Robert Frost, the poet considers the value or otherwise, of boundaries. In contemplating whether good fences make good neighbors, the governor did not want Mr. Dodge as his neighbor he was too near. Must be nice to be in a position as governor where you are able to increase your wealth.
John Jacques
BerlinMORE IN LettersAs the school year begins to wind down, we would like to take a moment to thank all of the... Full StoryVermonts cherished social fabric dates from when typical rural Vermonters were born and... Full StoryIt seems that there was a lot of extra security from private firms at the May Day celebration for... Full Story -
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text:
Beef Stew
- Total Time:
- 8 hr 10 min
- Prep:
- 10 min
- Cook:
- 8 hr
- Yield:
- about 2 quarts, 4 to 6 servings
- Level:
- Easy
- 2 tablespoons olive oil
- 2 pounds beef stew meat, cut into 1-inch pieces
- 1 1/2 teaspoons kosher salt
- 1 teaspoon Essence, recipe follows
- 3/4 teaspoon cracked black pepper
- 2 tablespoons unsalted butter
- 1/2 pound button mushrooms, thinly sliced
- 3 tablespoons all-purpose flour
- 3 cups veal or beef stock, at room temperature
- 2 tablespoons tomato paste
- 1/4 teaspoon dried thyme
- 1/4 teaspoon dried oregano
- 1/4 teaspoon dried basil
- 1/8 teaspoon ground allspice
- 1 pound small (golf ball size) new potatoes, quartered
- 1 cup diced carrots
- 1 cup frozen pearl onions, thawed
- 1/2 cup frozen green peas, thawed
- 1 tablespoon chopped fresh parsley leaves
Set a 12-inch saute pan over medium-high heat. Add 1 tablespoon of the olive oil to the pan and season the beef with 1 teaspoon of the salt, 1 teaspoon Essence and 1/2 teaspoon of the black pepper. Sear the beef (in 2 batches) in the saute pan for about 2 or 3 minutes per side.
Add the butter, mushrooms, flour, veal stock, tomato paste, herbs, spices, and browned meat to a slow cooker. Cover the slow cooker and set the temperature to high. Cook for 1 hour. Add the potatoes and carrots and continue to cook the stew for another 7 hours. During the last hour of cooking, add the pearl onions and replace the lid. Once the stew is cooked, stir in the peas and parsley and serve immediately.
Emeril's ESSENCE Creole Seasoning (also referred to as Bayou Blast):2 1/2 tablespoons paprika
2 tablespoons salt
2 tablespoons garlic powder
1 tablespoon black pepper
1 tablespoon onion powder
1 tablespoon cayenne pepper
1 tablespoon dried oregano
1 tablespoon dried thyme
Combine all ingredients thoroughly.
Yield: 2/3 cup
Recipe from "New New Orleans Cooking", by Emeril Lagasse and Jessie Tirsch, published by William Morrow, 1993.
Recipe courtesy Emeril Lagasse, 2006
Pairs Well With
Cabernet Sauvignon
Rich, intense red wine
- Find easy pairings for your favorite recipes, Bobby's perfect picks and party ideas.
Cooking Tips
More Recipes and Ideas
Beef Stew with Chocolate
Recipe courtesy of Sandra Lee
Beef Stew with Red Wine, Mushrooms and Horseradish Cream
Recipe courtesy of Amy Thielen


text:
Polycystic Kidney Disease
On this page:
- Autosomal Dominant PKD
- Autosomal Recessive PKD
- Genetic Diseases
- Hope through Research
- Points to Remember
- For More Information
Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys. The kidneys are two organs, each about the size of a fist, located in the upper part of a person's abdomen, toward the back. The kidneys filter wastes and extra fluid from the blood to form urine. They also regulate amounts of certain vital substances in the body. When cysts form in the kidneys, they are filled with fluid. PKD cysts can profoundly enlarge the kidneys while replacing much of the normal structure, resulting in reduced kidney function and leading to kidney failure.
When PKD causes kidneys to fail—which usually happens after many years—the patient requires dialysis or kidney transplantation. About one-half of people with the most common type of PKD progress to kidney failure, also called end-stage renal disease (ESRD).
PKD can also cause cysts in the liver and problems in other organs, such as blood vessels in the brain and heart. The number of cysts as well as the complications they cause help doctors distinguish PKD from the usually harmless "simple" cysts that often form in the kidneys in later years of life.
In the United States, about 600,0001 people have PKD, and cystic disease is the fourth leading cause of kidney failure. Two major inherited forms of PKD exist:
Autosomal dominant PKD is the most common inherited form. Symptoms usually develop between the ages of 30 and 40, but they can begin earlier, even in childhood. About 90 percent of all PKD cases are autosomal dominant PKD.
Autosomal recessive PKD is a rare inherited form. Symptoms of autosomal recessive PKD begin in the earliest months of life, even in the womb.
1 Grantham JJ, Nair V, Winklhoffer F. Cystic diseases of the kidney. In: Brenner BM, ed. Brenner & Rector's The Kidney. Vol. 2. 6th ed. Philadelphia: WB Saunders Company; 2000: 1699-1730.
Autosomal Dominant PKD
What is autosomal dominant PKD?
Autosomal dominant PKD is the most common inherited disorder of the kidneys. The phrase "autosomal dominant" means that if one parent has the disease, there is a 50 percent chance that the disease gene will pass to a child. In some cases—perhaps 10 percent—autosomal dominant PKD occurs spontaneously in patients. In these cases, neither of the parents carries a copy of the disease gene.
Many people with autosomal dominant PKD live for several decades without developing symptoms. For this reason, autosomal dominant PKD is often called "adult polycystic kidney disease." Yet, in some cases, cysts may form earlier in life and grow quickly, causing symptoms in childhood.
The cysts grow out of nephrons, the tiny filtering units inside the kidneys. The cysts eventually separate from the nephrons and continue to enlarge. The kidneys enlarge along with the cysts—which can number in the thousands—while roughly retaining their kidney shape. In fully developed autosomal dominant PKD, a cyst-filled kidney can weigh as much as 20 to 30 pounds. High blood pressure is common and develops in most patients by age 20 or 30.
What are the symptoms of autosomal dominant PKD?
The most common symptoms are pain in the back and the sides—between the ribs and hips—and headaches. The pain can be temporary or persistent, mild or severe.
People with autosomal dominant PKD also can experience the following complications:
- urinary tract infections—specifically, in the kidney cysts
- hematuria—blood in the urine
- liver and pancreatic cysts
- abnormal heart valves
- high blood pressure
- kidney stones
- aneurysms—bulges in the walls of blood vessels—in the brain
- diverticulosis—small pouches bulge outward through the colon
How is autosomal dominant PKD diagnosed?
Autosomal dominant PKD is usually diagnosed by kidney imaging studies. The most common form of diagnostic kidney imaging is ultrasound, but more precise studies, such as computerized tomography (CT) scans or magnetic resonance imaging (MRI) are also widely used. In autosomal dominant PKD, the onset of kidney damage and how quickly the disease progresses can vary. Kidney imaging findings can also vary considerably, depending on a patient's age. Younger patients usually have both fewer and smaller cysts. Doctors have therefore developed specific criteria for diagnosing the disease with kidney imaging findings, depending on patient age. For example, the presence of at least two cysts in each kidney by age 30 in a patient with a family history of the disease can confirm the diagnosis of autosomal dominant PKD. If there is any question about the diagnosis, a family history of autosomal dominant PKD and cysts found in other organs make the diagnosis more likely.
In most cases of autosomal dominant PKD, patients have no symptoms and their physical condition appears normal for many years, so the disease can go unnoticed. Physical checkups and blood and urine tests may not lead to early diagnosis. Because of the slow, undetected progression of cyst growth, some people live for many years without knowing they have autosomal dominant PKD.
Once cysts have grown to about one-half inch, however, diagnosis is possible with imaging technology. Ultrasound, which passes sound waves through the body to create a picture of the kidneys, is used most often. Ultrasound imaging does not use any injected dyes or radiation and is safe for all patients, including pregnant women. It can also detect cysts in the kidneys of a fetus, but large cyst growth this early in life is uncommon in autosomal dominant PKD.
More powerful and expensive imaging procedures such as CT scans and MRI also can detect cysts. Recently, MRI has been used to measure kidney and cyst volume and monitor kidney and cyst growth, which may serve as a way to track progression of the disease.
Diagnosis can also be made with a genetic test that detects mutations in the autosomal dominant PKD genes, called PKD1 and PKD2. Although this test can detect the presence of the autosomal dominant PKD mutations before large cysts develop, its usefulness is limited by two factors: detection of a disease gene cannot predict the onset of symptoms or ultimate severity of the disease, and if a disease gene is detected, no specific prevention or cure for the disease exists. However, a young person who knows of a PKD gene mutation may be able to forestall the loss of kidney function through diet and blood pressure control. The genetic test may also be used to determine whether a young member of a PKD family can safely donate a kidney to a family member with the disease. Individuals with a family history of PKD who are of childbearing age might also want to know whether they have the potential of passing a PKD gene to a child. Anyone considering genetic testing should receive counseling to understand all the implications of the test.
How is autosomal dominant PKD treated?
Although a cure for autosomal dominant PKD is not available, treatment can ease symptoms and prolong life.
Pain. Pain in the area of the kidneys can be caused by cyst infection, bleeding into cysts, kidney stone, or stretching of the fibrous tissue around the kidney with cyst growth. A doctor will first evaluate which of these causes are contributing to the pain to guide treatment. If it is determined to be chronic pain due to cyst expansion, the doctor may initially suggest over-the-counter pain medications, such as aspirin or acetaminophen (Tylenol). Consult your doctor before taking any over-the-counter medication because some may be harmful to the kidneys. For most but not all cases of severe pain due to cyst expansion, surgery to shrink cysts can relieve pain in the back and sides. However, surgery provides only temporary relief and does not slow the disease's progression toward kidney failure.
Headaches that are severe or that seem to feel different from other headaches might be caused by aneurysms—blood vessels that balloon out in spots—in the brain. These aneurysms could rupture, which can have severe consequences. Headaches also can be caused by high blood pressure. People with autosomal dominant PKD should see a doctor if they have severe or recurring headaches—even before considering over-the-counter pain medications.
Urinary tract infections. People with autosomal dominant PKD tend to have frequent urinary tract infections, which can be treated with antibiotics. People with the disease should seek treatment for urinary tract infections immediately because infection can spread from the urinary tract to the cysts in the kidneys. Cyst infections are difficult to treat because many antibiotics do not penetrate the cysts.
High blood pressure. Keeping blood pressure under control can slow the effects of autosomal dominant PKD. Lifestyle changes and various medications can lower high blood pressure. Patients should ask their doctors about such treatments. Sometimes proper diet and exercise are enough to keep blood pressure controlled.
End-stage renal disease. After many years, PKD can cause the kidneys to fail. Because kidneys are essential for life, people with ESRD must seek one of two options for replacing kidney functions: dialysis or transplantation. In hemodialysis, blood is circulated into an external filter, where it is cleaned before re-entering the body; in peritoneal dialysis, a fluid is introduced into the abdomen, where it absorbs wastes and is then removed. Transplantation of healthy kidneys into ESRD patients has become a common and successful procedure. Healthy—non-PKD—kidneys transplanted into PKD patients do not develop cysts.
Autosomal Recessive PKD
What is autosomal recessive PKD?
Autosomal recessive PKD is caused by a mutation in the autosomal recessive PKD gene, called PKHD1. Other genes for the disease might exist but have not yet been discovered by scientists. We all carry two copies of every gene. Parents who do not have PKD can have a child with the disease if both parents carry one copy of the abnormal gene and both pass that gene copy to their baby. The chance of the child having autosomal recessive PKD when both parents carry the abnormal gene is 25 percent. If only one parent carries the abnormal gene, the baby cannot get autosomal recessive PKD but could ultimately pass the abnormal gene to his or her children.
The signs of autosomal recessive PKD frequently begin before birth, so it is often called "infantile PKD." Children born with autosomal recessive PKD often, but not always, develop kidney failure before reaching adulthood. Severity of the disease varies. Babies with the worst cases die hours or days after birth due to respiratory difficulties or respiratory failure.
Some people with autosomal recessive PKD do not develop symptoms until later in childhood or even adulthood. Liver scarring occurs in all patients with autosomal recessive PKD and tends to become more of a medical concern with increasing age.
What are the symptoms of autosomal recessive PKD?
Children with autosomal recessive PKD experience high blood pressure, urinary tract infections, and frequent urination. The disease usually affects the liver and spleen, resulting in low blood cell counts, varicose veins, and hemorrhoids. Because kidney function is crucial for early physical development, children with autosomal recessive PKD and decreased kidney function are usually smaller than average size. Recent studies suggest that growth problems may be a primary feature of autosomal recessive PKD.
How is autosomal recessive PKD diagnosed?
Ultrasound imaging of the fetus or newborn reveals enlarged kidneys with an abnormal appearance, but large cysts such as those in autosomal dominant PKD are rarely seen. Because autosomal recessive PKD tends to scar the liver, ultrasound imaging of the liver also aids in diagnosis.
How is autosomal recessive PKD treated?
Medicines can control high blood pressure in autosomal recessive PKD, and antibiotics can control urinary tract infections. Eating increased amounts of nutritious food improves growth in children with autosomal recessive PKD. In some cases, growth hormones are used. In response to kidney failure, autosomal recessive PKD patients must receive dialysis or transplantation. If serious liver disease develops, some people can undergo combined liver and kidney transplantation.
Genetic Diseases
Genes are segments of DNA, the long molecules that reside in each of a person's cells. The genes, through complex processes, build proteins for growth and maintenance of the body. At conception, DNA—or genes—from both parents are passed to the child.
A genetic disease occurs when one or both parents pass abnormal genes to a child at conception. If receiving an abnormal gene from just one parent is enough to produce a disease in the child, the disease is said to have dominant inheritance. If receiving abnormal genes from both parents is needed to produce disease in the child, the disease is said to be recessive. A genetic disease can also occur through a spontaneous mutation.
The chance of acquiring a dominant disease is higher than the chance of acquiring a recessive disease. A child who receives only one gene copy for a recessive disease at conception will not develop the genetic disease—such as autosomal recessive PKD—but could pass the gene to the following generation.
Hope through Research
Scientists have begun to identify the processes that trigger formation of PKD cysts. Advances in the field of genetics have increased our understanding of the abnormal genes responsible for autosomal dominant and autosomal recessive PKD. Scientists have located two genes associated with autosomal dominant PKD. The first was located in 1985 on chromosome 16 and labeled PKD1. PKD2 was localized to chromosome 4 in 1993. Within 3 years, scientists had isolated the proteins these two genes produce-polycystin-1 and polycystin-2.
When both the PKD1 and PKD2 genes are normal, the proteins they produce work together to foster normal kidney development and inhibit cyst formation. A mutation in either of the genes can lead to cyst formation, but evidence suggests that disease development also requires other factors, in addition to the mutation in one of the PKD genes.
Genetic analyses of most families with PKD confirm mutations in either the PKD1 or PKD2 gene. In about 10 to 15 percent of cases, however, families with autosomal dominant PKD do not show obvious abnormalities or mutations in the PKD1 and PKD2 genes, using current testing methods.
Researchers have also recently identified the autosomal recessive PKD gene, called PKHD1, on chromosome 6. Genetic testing for autosomal recessive PKD to detect mutations in PKHD1 is now offered by a limited number of molecular genetic diagnostics laboratories in the United States.
Researchers have bred rodents with a genetic disease that parallels both inherited forms of human PKD. Studying these mice will lead to greater understanding of the genetic and nongenetic mechanisms involved in cyst formation. In recent years, researchers have discovered several compounds that appear to inhibit cyst formation in mice with the PKD gene. Some of these compounds are in clinical testing in humans. Scientists hope further testing will lead to safe and effective treatments for humans with the disease.
Recent clinical studies of autosomal dominant PKD are exploring new imaging methods for tracking progression of cystic kidney disease. These methods, using MRI, are helping scientists design better clinical trials for new treatments of autosomal dominant PKD.
People interested in participating in clinical trials of new treatments for PKD can find a list of centers recruiting patients at www.ClinicalTrials.gov.
Points to Remember
The two forms of polycystic kidney disease (PKD) are
- autosomal dominant PKD, a form that usually causes symptoms in adulthood
- autosomal recessive PKD, a rare form that usually causes symptoms in infancy and early childhood
The symptoms and signs of PKD include
- pain in the back and lower sides
- headaches
- urinary tract infections
- blood in the urine
- cysts in the kidneys and other organs
Diagnosis of PKD is obtained by
- ultrasound imaging of kidney cysts
- ultrasound imaging of cysts in other organs
- family medical history, including genetic testing
PKD has no cure. Treatments include
- medicine to control high blood pressure
- medicine and surgery to reduce pain
- antibiotics to resolve infections
- dialysis to replace functions of failed kidneys
- kidney transplantation
The U.S. Government does not endorse or favor any specific commercial product or company. Trade, proprietary, or company names appearing in this document are used only because they are considered necessary in the context of the information provided. If a product is not mentioned, the omission does not mean or imply that the product is unsatisfactory.
For More Information
Polycystic Kidney Disease Foundation
9221 Ward Parkway, Suite 400
Kansas City, MO 64114–3367
Phone: 1–800–PKD–CURE (753–2873) or 816–931–2600
Email: firstname.lastname@example.com
Internet: www.pkdcure.org
American Association of Kidney Patients
3505 East Frontage Road, Suite 315
Tampa, FL 33607
Phone: 1–800–749–2257 or 813–636–8100
Email: firstname.lastname@example.com
Internet: www.aakp.org
National Kidney Foundation
30 East 33rd Street
New York, NY 10016
Phone: 1–800–622–9010 or 212–889–2210
Internet: www.kidney.org
You may also find additional information about this topic by visiting MedlinePlus at www.medlineplus.gov.
This publication may contain information about medications. When prepared, this publication included the most current information available. For updates or for questions about any medications, contact the U.S. Food and Drug Administration toll-free at 1–888–INFO–FDA (1–888–463–6332) or visit www.fda.gov. Consult your doctor for more information.
National Kidney and Urologic Diseases Information Clearinghouse
3 Information Way
Bethesda, MD 20892–3580
Phone: 1–800–891–5390
Fax: 703–738–4929
Email: firstname.lastname@example.com
Internet: www.kidney.niddk.nih.gov
The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Established in 1987, the Clearinghouse provides information about diseases of the kidneys and urologic system to people with kidney and urologic disorders and to their families, health care professionals, and the public. The NKUDIC answers inquiries, develops and distributes publications, and works closely with professional and patient organizations and Government agencies to coordinate resources about kidney and urologic diseases.
Publications produced by the Clearinghouse are carefully reviewed by both NIDDK scientists and outside experts. This publication was reviewed by Lisa Guay-Woodford, M.D., University of Alabama at Birmingham, and Stefan Somlo, M.D., Yale University.
This publication is not copyrighted. The Clearinghouse encourages users of this publication to duplicate and distribute as many copies as desired.
NIH Publication No. 08–4008
November 2007
Page last updated September 2, 2010