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Pharmacokinetic Interactions Between Antiretroviral Agents and Antimalarial Drug Combinations
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The purpose of the study is to determine in healthy volunteers whether certain anti-HIV medications (lopinavir/ritonavir and efavirenz) affect the drug levels of certain anti-malarial medications (artesunate/ amodiaquine and artemether/ lumefantrine) and vice versa. Since these drugs are degraded using overlapping pathways in the liver, it is predicted that changes in both drug level and overall drug exposure will be observed.
Condition | Intervention | Phase |
HIV Infections Malaria |
Drug: lopinavir/ritonavir Drug: efavirenz Drug: artemether/lumefantrine |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Pharmacokinetics Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | Pharmacokinetic Interactions Between Antiretroviral Agents, Lopinavir/Ritonavir and Efavirenz and Antimalarial Drug Combinations, Artesunate/Amodiaquine and Artemether/Lumefantrine. |
- AUC (zero to infinity) of the antimalarial agent [ Time Frame: Each 3-day antimalarial treatment course throughout study ] [ Designated as safety issue: No ]
Enrollment: | 38 |
Study Start Date: | July 2005 |
Study Completion Date: | December 2010 |
Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Group A4
healthy volunteers assigned to the efavirenz with artemether/lumefantrine intervention
Drug: efavirenz
One 600mg tablet orally once daily before bedtime on an empty stomach for 26 days
Other Name: Sustiva
Drug: artemether/lumefantrine
4 tablets of artemether 20mg/lumefantrine 120mg twice daily with food. 2 three-day courses will be administered (with washout in between) during the duration of the trial.
Other Name: Coartem
Experimental: Group A3
healthy volunteers assigned to the lopinavir/ritonavir with artemether/lumefantrine intervention
Drug: lopinavir/ritonavir
Two tablets of lopinavir 200mg / ritonavir 50mg orally twice daily with food for 26 days
Other Name: Kaletra
Drug: artemether/lumefantrine
4 tablets of artemether 20mg/lumefantrine 120mg twice daily with food. 2 three-day courses will be administered (with washout in between) during the duration of the trial.
Other Name: Coartem
Detailed Description:
HIV and malaria are two of the most pernicious diseases facing developing countries. Malaria affects 300 to 500 million individuals annually in developing countries and it is estimated that 25.8 million people in Africa live with HIV. Current therapy recommended by the World Health Organization includes the use of artemisinin derivatives, such as artesunate and artemether. To minimize the risk of resistance, these drugs are used in combination with older drugs with longer half-lives including amodiaquine and lumefantrine.
Treatment of malaria is further complicated by the increasing availability of antiretroviral (ARV) medications for HIV in that clinically important drug-drug interactions may occur in co-infected patients. Protease inhibitor (e.g. lopinavir and ritonavir) and non-nucleoside reverse transcriptase (e.g. efavirenz) based treatment commonly affects pharmacokinetic exposure of drugs metabolized by cytochrome P450 (CYP) metabolic pathways.
Artemether is metabolized by the CYP3A4 to active dihydroartemisinin (DHA), while artesunate is hydrolyzed to DHA. Lumefantrine is an active compound that is metabolized by CYP3A4. Amodiaquine is an active "prodrug" that is quickly metabolized to an active metabolite N-desethylamodiaquine (DEAQ) by CYP2C8. In addition, these antimalarial drugs may also affect the metabolism of CYP substrates, such as ARVs.
The primary objective of this study is to investigate the effects of ARV agents (ritonavir/ lopinavir (Kaletra) and efavirenz) on the pharmacokinetics of antimalarial drug combinations [artesunate/ amodiaquine and their active metabolites, and artemether/ lumefantrine (Coartem®) and their active metabolites]. The secondary objective is to investigate the effects of antimalarial drug combinations [artesunate/amodiaquine and artemether/lumefantrine (Coartem®)] on the pharmacokinetics of ARV drugs [lopinavir/ritonavir (Kaletra®) and efavirenz].
If clinically important interactions occur, net effects may include improved or diminished antimalarial activity (as activity is attributed to both the parent drug and the active metabolite(s)) and drug toxicity. The study in HIV negative healthy volunteers will allow rapid assessment of these potential interactions and will provide essential data for optimizing a future clinical study and the use of ARVs and antimalarials for children and adults in Uganda.
Currently the components of the study involving the impact of ARVs on artesunate/amodiaquine are not being pursued (and recruitment for those arms was conducted separately), so there are only two groups in the presently-approved trial: one in which the effects of lopinavir/ritonavir on artemether/lumefantrine are studied and another in which the effects of efavirenz on artemether/lumefantrine are studied.
Ages Eligible for Study: | 21 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Absence of HIV infection prior to study entry
- Male or female aged 21-60 who are able to provide informed consent
- Subject is within 20% (+/-) of ideal body weight and weighs at least 50 kg.
- Healthy, without evidence of acute or chronic illness including diabetes, hypertension, CAD, psychiatric illnesses, renal or hepatic impairment.
- Screening laboratory tests that are normal or deemed not clinically significant by the study physician.
- Female subjects of reproductive potential must agree to the use of two forms of birth control methods for at least one month prior to study enrollment and for 6 weeks following study completion
- Female subjects must have a negative pregnancy test within 24 hours before receiving any study drugs.
Exclusion Criteria:
- Use of illicit drugs or alcohol that could interfere with the completion of the study
- Use of any over-the-counter or prescribed drugs unless approved by the principal investigator or study physician
- Use of drugs that are known to inhibit/induce CYP450 isozymes or are substrates of CYP3A4, CYP2D6, CYP2C8 enzymes (use of hormonal contraceptives is permitted).
- Pregnant or breastfeeding
- History of acute or chronic illnesses, such as diabetes, hypertension, CAD, psychiatric illnesses, renal or hepatic impairment.
- Evidence of acute illness
- Family history of congenital prolongation of QTc interval or with any conditions known to prolong QTc interval such as cardiac arrhythmias, bradycardia, or severe heart disease
- History of hypokalemia, hypomagnesemia, or hypercholesteremia
Please refer to this study by its ClinicalTrials.gov identifier: NCT00697892
United States, California | |
San Francisco General Hospital | |
San Francisco, California, United States, 94110 |
Principal Investigator: | Francesca T Aweeka, PharmD | University of California, San Francisco |
No publications provided
Responsible Party: | Fran Aweeka, Sponsor-Investigator, University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00697892 History of Changes |
Other Study ID Numbers: | H6930-27654 |
Study First Received: | June 2, 2008 |
Last Updated: | June 4, 2013 |
Health Authority: | United States: Food and Drug Administration |
Keywords provided by University of California, San Francisco:
Human Immunodeficiency Virus Drug Interactions |
Additional relevant MeSH terms:
Anti-Retroviral Agents Antimalarials Artemether Artemether-lumefantrine combination Artemisinins Efavirenz Lopinavir Lumefantrine Ritonavir Anthelmintics Anti-HIV Agents Anti-Infective Agents Antifungal Agents Antiparasitic Agents |
Antiplatyhelmintic Agents Antiprotozoal Agents Antiviral Agents Coccidiostats Enzyme Inhibitors HIV Protease Inhibitors Molecular Mechanisms of Pharmacological Action Nucleic Acid Synthesis Inhibitors Pharmacologic Actions Protease Inhibitors Reverse Transcriptase Inhibitors Schistosomicides Therapeutic Uses |
ClinicalTrials.gov processed this record on May 05, 2015


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SBA Pumpkin War!
Posted October 17th, 2013 by Patrick Walsh
Can you imagine your favorite professor teaching class in a full clown costume, including big shoes, a red nose, and a rainbow wig? Your imagination may soon become a reality, because SBA's Pumpkin War is back! In the Mosaic Lobby from now until Halloween, put your extra change in the pumpkin of your choice and vote for your favorite participating professor. At the end of the War, the professor whose pumpkin has raised the most money will have to dress like a clown for one class period. So put your spare change to use and help us find the 2013 Pumpkin War Champion!

subset: commoncrawl


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"love the man"
love the men in this series but this book can try your nerves. the book over all is good would have been great if the female lead did not talk the way she does with all those thes. what happen to words like you? other then that it was a good book. cant wait for the next one...just hope she talks normal.
"Fell flat"
I was so excited for this book, preordered it, went back and listen to I'm Dreaming of a Dead Christmas to get ready for this book. Then it was like.....WHAT? What happen to the chemistry and the excitement? Some where between the last book and Gigi and Nick's actual love story all that I had been waiting on and all the excitement just left! I even rewind my player thinking I missed a crucial point between Gigi finding out who Nick was and the moment they jumped into the sack......what happened to build up, why so much trust even when he was trying to kill her. This story just did not play out right for my taste. Too many times I found myself wanting to slap one of the characters and found that the love was to instant!
"Not for adults"
I waited for awhile to get this book since it was not an audiobook. The moment it was released I snatched it up. I love these types of story lines and this is the type of book I was in the mood for but it just did not do the trick.
If the author would take out the cussing then this book would be for children.
There is not really an ending. She just goes back to New York. Nothing really gets resolved. Where is my HEA? Where was the romance? The only thing that saves this book from being 1 star is the practical jokes the kids played on each other. I would skip this book in less you are a young teenager.
"Son of who?"
This is probably my least favorite of all SK's novels. I started this book looking for the pulse pounding heart stopping action that I have come to expect and this book just did not deliver. The sarcasm was not in this book like previous books.
We do get some insight into Thorn and Jaden. We get to see some old fav's like Ash, Simi, Styxx, Kat, and Fang. There is a cliff hanger about Sav that make you think hum......
Things I did not like about the book was the instat love expecially since Joe just got divorced. I did not feel the love connection, it kept feeling like she pitted him and he loved her because she was there. The multiply names for characters, made me confused for awhile. The new people I have never heard of from the LOA series.
I will reread this just because I know I did not catch it all the first time for all the confusion between the characters names and the new people. I am looking forward to the next book! I was happy to see Holter back as the narrator. The brogue speak was hard to understand for me as well. I think that is my issue with my hearing rather than the narrator though.
"Does anyone care anymore?"
The narration was flat no life what so ever. She made the characters sound nothing like teenagers and lifeless. Grated on my last nerve!
This is like the umpteenth book that I have bought recently that was a last book in a series. I do not know what is going on with the narrators and authors. If you do not want to write the book DO NOT WRITE THE BOOK! Do not just throw together something because fans are asking for more. And for the love of GOD please chose a narrator that brings something to the book not kills all enjoyment!
I can not say if I like this book at all the narration was so bad. I tired my best to focus on the story but these characters (hopefully just due to narration) was horrible and I hated them. Which sadly disappoints me because I so loved them in the last book so that why I think it was the narration that made me hate them in this one.
Do your self a favor and pass on the audio with this one. It will turn you away and this author has never been a disappointment before.
"Horrible narration"
Yes just because it is the last in a series that was awesome until now.
I loved the first 4 books in this series, was not so wild about the 5th due to horrible narrators and not so wild about this one for the same reasons.
Narration fail flat. Words were mispronounced which drove me nuts! It felt lifeless. All this action was happening according to the words being said but I was not living in the moment like I did with the first 4 books.
It inspired me to never preorder a book again with out being familiar with the narrator.
After listening to the whole 20 something hours of this book I still cant tell if I even liked it. The narration was so bad I found myself asking is it over yet?! That is not a good thing when this author has always keep me on the edge of my seat. This is the second book (book 5 being the other one) that I walked away trying to remember what happened in the book and trying to figure out if I even like the book. This is terribly disappointing.
"Here comes the bride!"
But who's the bride.......who's the groom?!?! We get a wedding, funerals, and some heartbreak! I can't tell you who ends up in which of those list but trust me you will want to know. I am sadden that a very lovely lady died in this book. I wish the author would of kept her alive, I think there was a lot more to her story then we have heard. I think she would of been proud of the outcome and the future of this world that we have lived in over the course of these books. Aspen stole my heart in this book and Maxon made me love him even more and want to slap him at times. We get to visit with Marley and get to see a side of the Elite that we have never seen. There is love, war, and death. You must read the book as I will not give any spoilers away. Is this book worth the credit/money and time? YES! What are you waiting for?
"Not much difference"
There is not much difference between this book and Fallen Too Far. The only thing with this one is I found out the connection a lot sooner between Blair and Nan then you did in Fallen Too Far. I do not feel as if I gained any insight into Rush. I feel as if I learned more of him in the other books. I did like hearing this narration however. I loved getting to see Jace and Woods from Rush's point of view! Grant however came off as a total douche in this book lol. Just goes to show how men will act one way with their women and another with their boys.
Laugh out loud till you can no longer breath and have tears running down your face funny! The most hilarious book I have ever read!
Warnings: This book contains a lot of profanity, rude remarks, sexual undertones, sex toys, chocolate, violence, drinking, and drugs.
This book is not for those who lack a sense of humor or those who are uptight!
Now that is out of the way. Let me tell you to GRAB this book now if you are the types of person who can handle all the warnings. You will not regret this book at all. You will laugh like you have never laughed before. I imagine that everyone can relate to this book in one of the many LOL moments, rather it be things you may have thought or things you may have wanted to say to someone but was too nice to say them.
The characters are loveable but are no holds bars with their way of speech. I think these characters could even make sailors blush. (Cruse like a sailor) remember those words because sailors aint got nothing on this group!
This book starts of with Claire who is a virgin, one night at a college party she meets a guy and decides its time to pop her cherry. From there the laughs begin. I do not want to go into to much of the story so I will stop there. The story is written to where you know what they are thinking inside of their heads ( you know those thoughts you say to yourself but never dare say out loud since its no PC) yeah!!! Then you have those random thoughts that you think so loud that they pop out your mouth and every one's jaws hit the floor! LMAO!!!!
This book is all kinds of crazy ass fun! A laugh a minute that one can not ever regret. If you love comedy and/or America's funniest videos, I highly suggest you pick up this book.
"The End!"
I got this book because of the good reviews, one in particular, she has never failed me. However I do not see why people have loved this book so much. It was funny and romantic but it got to the point I was screaming ENUFF ALREADY! For me this book was just a little too long for the main story line. By the end of the book if I heard one more time about him being a 10.5 and her being a 2.5 I would have screamed. I just wanted to knock some sense into Mara. The ending however when the big oh no happened felt rushed. If the author would of token out some of the .5 stuff and add more to that OH NO scene then this book might of been a 4. But since I had to listen to all that point this and that for so long I can not give this book more then 3 stars. This book could of been half as long and been better. I am just happy I did not pay full price for it.
"Oh Jason!"
This is one of the best most funniest books I have ever read. Besides the 2nd and 3rd book in this series. If you ever need a book to put you in a good mood I highly recommend this series. It will have you laughing till you cry. The romance is awesome. Love scenes smoking hot. I will definitely be reading this series again and again!
I love that the hero's name is Jason. I always have been a sucker for a guy name Jason lol.


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It doesn't get much better than this for your budget Key West vacation! Located at the 1200 block of world famous Duval St. Mermaid's Cove is ideal for your Key West getaway. It puts you in the heart of downtown, old town Key West with access to all kinds of activities. Just 2 blocks from the Atlantic Ocean beach, liquor stores, a CVS and right next store to Smoothie Shuttle and Banana Café.
Consisting of 4 separate units (2 cottages and 2 apartments), each with a private entrance, they surround a central courtyard with outdoor patio furniture and a large gas BBQ grill. Mermaid's Cove will allow you to be a group but still enjoy privacy.
Apartment 1 is an upstairs unit with a king bed, full kitchen, bath with shower and living room with full sleeper sofa and a wall unit a/c. The living room features a large flat screen TV/DVD player and has French doors opening onto a deck with teak furniture and table. Sleeps 4.
Apartment 2 is a downstairs unit with 2 twin beds, full bath with shower, mini kitchen with under-the-counter fridge, microwave, toaster oven, coffee maker, blender, TV/DVD, and a wall unit a/c. Sleeps 2.
Cottage 1 has a king bed and is in a free-standing unit with French doors opening onto the central courtyard. The bath includes a shower. The kitchen has a full size fridge, microwave, toaster oven, coffee maker, blender, TV/DVD and wall unit A/C. Sleeps 2.
Cottage 2 is at the rear of the courtyard and features sweet smelling natural cedar walls. At the entrance is a beautiful mosaic tiled 20′ wall with a one-of-a-kind mural of a Key West beach scene with a Mermaid! This unit features a queen size bed, kitchen with a full size fridge, microwave, toaster oven, coffee maker, blender, flat screen TV/DVD, small sitting area/dining table with pull-out futon and wall unit A/C. The bath includes a shower. Sleeps 4.
"Fabulous Stay in Key West"
We had a wonderful stay at Mermaid's Cove. We totally enjoyed the little courtyard and the quaint room that we stayed in. It had all the comforts of home but with the added touch of the islands. We totally recommend this location to anyone that is looking for a little get-a-way. Barbara, Hernando, FL
This place is the perfect place to stay in Key West. It's on the quiet end of Duval St. and has lots of good restaurants around it. The sandy beach is a 5 min walk. Our cottage was clean and cute…like staying at a friend's home. We bought steaks and used their BBQ on the shared patio. This was truly a unique and comfortable vacation! We highly recommend The Cove and will return next year!! Dallas, Texas


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OpenCongress Blog
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Unemployment Extension Vote Live-Blog
October 27, 2009 - by Donny ShawWith the jobless rate at 9.8 percent and rising, Senate Democrats have scheduled a big vote this afternoon to move forward with their bill to extend unemployment insurance benefits (H.R. 3548), which has been blocked by Republicans for the past month. I'll be live-blogging the debate and the vote here and I invite you to help me out in comments section with capturing all the key quotes and information. The debate is scheduled to begin at around 5:30 pm ET with a vote taking place at 6:00, and it will be televised live on C-SPAN 2 (live online video here).
In the past month, Majority Leader Sen. Harry Reid [D, NV] has repeatedly tried to speed up passage of the bill under a unanimous consent agreement. But Republicans objected each time and said that they were seeking changes related to the bill's funding (and a few changes that are totally unrelated). More details on the process so far can be found on the OpenCongress Benefits Wiki.
Today's vote is to invoke cloture on the motion to proceed to an official debate of the bill. Invoking cloture requires 60 votes, and if it is approved the bill will move to the Senate floor for votes on amendments. Another cloture vote will likely be necessary to end the debate and bring the bill to a final up-or-down vote. The process will become clearer as the debate picks up, and I'll be trying to keep track of it all here. Stay tuned!
4:30 p.m.: Reuters is reporting that bipartisan senators are very close to a deal for extending the $8,000 tax credit for first-time homebuyers. No specifics out on the deal yet, but apparently it may be voted on tonight as an amendment to the unemployment bill. If it's added, it is going to slow down the House's action on approving the Senate's amended unemployment bill.
4:47 p.m.: Senators are filtering back into the chamber and starting to give floor speeches on the unemployment bill. Sen. Cardin (D-MD) is up with a map of his state explaining why the Senate is changing the House bill to apply the extension to every state. Maryland's jobless rate is a little lower than the national average — it's around 7% — but individual counties within the state have rate as high as 10.8%. Under the House bill, those counties would not have been given the extension while a county in another state with a lower rate but a statewide average above 8.5% would get the extension.
5:03 p.m.: Here's a link to the roll call details on the motion to invoke cloture on the motion to proceed to the UI benefits extension that the Senate passed last November. The motion passed 89-6 back then when the jobless rate was at 6.7%.
5:15 p.m.: Majority Leader Reid (D-NV) is up for what is probably the last speech before the cloture debate begins: Approximately 150,000 people have run out of unemployment benefits since the Republicans began delaying this bill 3 weeks ago. "We have the power and the ability to act. Let's do it!" "Republican response to helping the unemployed is 'No!'"
5:30 p.m.: OK, the debate on the cloture motion on the motion to proceed is officially beginning and it's time for opening statements. Finance Committee Chairman Max Baucus (D-MT) is up first. "Total cost for our bill $2.4 billion, payed for with an extension of the federal unemployment tax."
5:40 p.m.: Via OpenCongress user JMatzelle57, breaking news:
Senate Majority Leader Harry Reid (D-Nevada) announced this afternoon, Tuesday October 27, that an extension of the $8,000 first-time homebuyer credit and more generous net operating loss carry-back rules for money-losing businesses will not be brought to the Senate floor for a vote. The unemployment insurance extension is still on the calendar and will be brought up as a stand-alone measure. HAI will provide updates as more information is released from Capitol Hill.
We'll see if that's accurate…
5:47 p.m.: Sen. Dorgan (D-ND) up: "Some of the people who are stalling the unemployment extension benefits were the same ones who rushed to the starting line last fall to see if they couldn't hand hundreds of billions of dollars to the banks that ran this country into a ditch."
5:50 p.m.: Really? No Republicans are going to speak on extending unemployment benefits? Vote's in 10 minutes, it's looking that way.
6:00 p.m.: The vote is underway …and it's impossible to hear on C-Span how anyone is voting.
6:20 p.m.: Vote's not quite over, but they're well past 60 "ayes." Here's my running tally of the "noes" (13 so far):
Sen. John Barrasso [R, WY]
Sen. Christopher Bond [R, MO]
Sen. Jim Bunning [R, KY]
Sen. Thomas Coburn [R, OK]
Sen. John Cornyn [R, TX]
Sen. Jim DeMint [R, SC]
Sen. Michael Enzi [R, WY]
Sen. Lindsey Graham [R, SC]
Sen. Orrin Hatch [R, UT]
Sen. James Inhofe [R, OK]
Sen. Mike Johanns [R, NE]
Sen. Jefferson Sessions [R, AL]
Sen. David Vitter [R, LA]
Sen. Roger Wicker [R, MS]
6:26 p.m.: And that does it. Final vote tally is 87-13. The motion to proceed is agreed to.
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Displaying 1-30 of 344 total comments.
what the hell am i supposed to do for money while these bureaucrats twiddle their thumbs? there are no jobs to be found. i've traveled across 4 different states looking for work only to be turned away. my kids have needs, my husband and i have needs and i'm sick of putting those needs on the back burner. i thought this was america! i don't want to depend of unemployment, but it's there because i worked for it if i needed. i need it so give it to me!!!! it's mine!!!!!
I am not affiliated with any political party, but after reading on various sites and looking at the official list of Republican amendmants that have nothing to do with "Unemployment benefits help to people who NEED IT", I will never ever ever vote for any Republican again EVER. If you are a Republican, and need unemployment look at how your party is treating you, and remember that come election time.
My thoughts exactly. Like Senator Reid said the other day, he can count on 2 fingers the numbers of Republicans who are on board for unemployment, health care, etc. Obviously, this party is so scared that Obama is actually going to make a big difference, they are attempting to stonewall everything they can. Reid also said the same Republicans who are against the unemployment bill are the same people who were beating down the doors to vote to give TARP money to the banks/car makers. Just goes to show where their allegiance is – big business. They have no clue about the middle class. I'll never vote for a Republican either. I hope they all are shooting themselves in the foot right now with their lack of cooperation.
Two from S.C. voted 'naye ' the very ones who SAID they supported another extension…they should all be ' fired' by WE who hired them come next election …and S.C. lawmakers already had to reconvene today just to get the extra benefits from the last extension…these politicians are selfish…help Wall Street but not taxpayers…just remember …as you sow, so shall ye reap….these politicians best be praying for a failed harvest because what they are sowing is getting themselves in need of unemployment benefits…
Moderated Comment
I guess your working! I have been off for over a year and I can't get a job a McDonald or Burger King. I was a quality manager for 16 years with the automotive sector and can't even find a part time job for minimum wage. I have lowered my standard but it hasn't helped. so that that!
I think that the person that said Get up off your butt and find a job….IS SO RUDE…..I have not been employed for almost 2 years now, it sucks and believe me I have been trying to find a job daily…..I THINK THAT YOU SHOULD COME DOWN OFF YOUR HIGH HORSE AND HAVE A LITTLE BIT OF CONSIDERATION FOR OTHERS.
Here's a crazier thought, a-hole. My job was sent overseas & now I'm a full time student trying to support myself. The government should support me as I learn a new trade or stop giving our jobs to India. I have a job & am going to school full time for ultrasound and can't pay my bills w/out collecting partial UE. I need this extension since working for minimum wage pays only a portion of my bills. I hope you lose your job someday and find out how it feels.
Our Money is correct. These senators are worse than the old Roman Senate wearing there white robes. It is known that for every dollar given out in UI 1.67 is returned to the economy. I like Reid and hate Hatch. I guess he has too many wives to feed.
I was on my job for 15years US Customs broker
Well I lower my standards and guess what? I haven't worked a full week at my NEW job yet. I get laid off every 3days But when they call me back I'm the first one there. I'm continue my job search but nothing found yet. You must have a job that's why you don't understand. You must walk the walk to understand the talk. You must be from the Republican Party. I pray you don't feel this pain my family is feeling have a bless life.
People need help -
- I am not from the republican party
- I garuntee I've been in a worse situation than you. The difference is I bucked up and got a job that was less than ideal… know what it was? I cleaned toilets at the local high school. Even then, I was making around $400/month
- Yes I do have a job, BUT I was unemployed as of two months ago. With that said, I knew full and well that I might have to pick up a job at the local fastfood joint in order to support the family. Possibly pick up two jobs.
- I honestly feel for your situation, HOWEVER, can you honestly say that you started looking at jobs like that? A job is a job mate.
What ….you do not have any idea what you are talking about…I have worked all my life….babysat when I was 14 years old…if you know where all the jobs are…tell us list them!!! You must have nothing in your life…I have a mortgage…I need to pay that mortgage..you know where job is that will pay my mortgage??? Give me the name and number I will go to work today…you need to keep your stupid talk to yourself!!!
REALLY! I am struggling as so many others are also. I am SICK AND TIRED of Republicans!! I always vote Democrat. Republicans seem to be cold-hearted, money hungry, ignorant, and self-centered! I am fortunate, I guess you can call it that, enough to live in my parents' basement and live off what they provide for me until I collect again or EVEN BETTER, GET A JOB! I am an educated person, and always worked hard for my money. I can't even get a lousy job at a local Taco Bell because I am AMERICAN!!! WTF! LET'S GO! PASS THE BILL ALREADY! I feel sorry for the many people who can't afford a decent Thanksgiving dinner – Republicans will be enjoying their GOURMET Thanksgiving dinners for sure without a care for the less fortunate!! Come on! Show some compassion and pass the bill!!!!!!!
Yeah Enuf is enuf they need to quit the stall tactics and give help to all of us that are in dire needs. I will reiterate Jans1116 post by saying Thanks to O/C and Donny.
bassmaster I am actually listening to bass creator right now by basshunter do you know who they are?
No srry dont have a clue.My nick refers to fishing not the thump :-)
First of all, I support the extension of unemployment comp. HOWEVER, this is not going to fix the unemployment problem. How many of you people have actually tried working at Arby's or Denny's in the interim so that you have SOME income.
I recently faced the realities of unemployment. I accepted the fact in order to support my family, I NEEDED to find a job. If that job was delivering Pizza or waiting tables or cleaning toilets, I knew that is what I needed to do to support my family! The problem with all you people is that you're too snobbish to bite the bullet and do what needs to be done. It's pathetic.
your Pathetic! Every job I have applied and continue to apply for says "your over qualified". When everyone is unemployed, they want the people who have experience in delivering pizza or waiting tables or fast food … Don't you think people are trying to find anything they can at this point. Do you really think they are just sitting around while their children starve? Aren't you a little full of yourself! You must be a Republican!


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editGiant Corpse Crab | |
(躯大蟹, Mukuro Ōkani) | |
Debut | |
Anime | Naruto Shippūden Episode #225 |
Appears in | Anime |
Personal | |
Species | Crustacean |
Status | Presumed Deceased |
The Giant Corpse Crab (躯大蟹, Mukuro Ōkani) was a giant crustacean that inhabited the waters somewhere between the Land of Fire and the Land of Lightning.
The Giant Corpse Crab once attacked and destroyed a ship which a young sailor named Hishaku sailed on, killing the whole crew.
The Giant Corpse Crab had razor sharp pincers, as well as an extremely hard shell. The barnacles on its shell could eat live humans. It had tentacle like appendages that could be used to grab its prey.
Part II
Adventures At Sea Arc
While the ship with Naruto, Aoba, Yamato and Might Guy on it was on route to the Land of Lightning from the Land of Fire, the crab attacked a seemingly abandoned ship that the shinobi had encountered out at sea taking Yamato captive. It was subsequently killed through the combined efforts of the shinobi and a ghost of Hishaku.


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Oh man oh man oh man. I was asked last night if I would speak tonight. The person who was scheduled to speak became ill.
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Wish me luck


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UN.GIFT Publications
CSO HRW Domestic Workers in Asia and MENA
Oct 05 2010
Download right click "save as"
Several countries across the Middle East and Asia host significant numbers of migrant domestic workers, ranging from 196,000 in Singapore to approximately 1.5 million in Saudi Arabia. Increased reporting and awareness about abuse against these workers has resulted in active policy debates and in some cases change. Building upon six years of research, this report surveys the patterns of labor, immigration, and criminal justice reforms in Saudi Arabia, Kuwait, the United Arab Emirates, Bahrain, Lebanon, Jordan, Singapore, and Malaysia, highlighting both best practices and continuing gaps. More information about human trafficking on the website of HRW.
- How to prevent human trafficking for domestic servitude in diplomatic households and protect private domestic workers
- 2014 Global Trafficking in Persons report - full
- US State Department Trafficking in Persons Report 2014
- 3rd General report on GRETA's activities
- Walk Free Global Slavery Index 2013
- ILO: Marking progress against child labour: Global estimates and trends 2000-2012
- IOM: A Situational Analysis of Aruba's Response to Human Trafficking
- Report by OSCE Special Representative and Co-ordinator for Combating Trafficking in Human Beings, following her visit to Bosnia and Herzegovina, 12-14 June 2012
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- Report of the Special Rapporteur on trafficking in persons, especially women and children, Joy Ngozi Ezeilo


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Could someone be so kind and explain me what exactly is GLU library? Thanks!
Phoronix: GLU3 1.0 Expected In About One Month
Going back to last April, Intel's Ian Romanick has been working on GLU3 and yesterday afternoon on his blog he has announced some changes. The GLU3 code-base has moved to a new FreeDesktop.org Git repository, there is now a project mailing list, and he expects to finally release GLU3 1.0 within one month or so...
Could someone be so kind and explain me what exactly is GLU library? Thanks!
Based on the name I expect a GLU replacement solely for OpenGL 3 and higher.
that's what it looks like. but what is glu? is it a competitor to glew?
ah, reporting news on topic that wasn't previously discussed, without any introduction to the subject. what's the point?
i don't want to sound annoying, but that's what i've seen a couple of times on phoronix already.
Well, let me chime in and ask what the heck GLU3 exactly is/does/replaces/...
Neither the article nor the blog give away those secrets.
also confused
I have no idea what any of this is about, but hey, at least it's not some rant.
OK, here's a bit more explanation:
The GLU or GL utility library is supplied alongside OpenGL to provide higher level functions (e.g. rendering Quadrics objects (spheres etc.), helper functions like gluPerspective etc.)
When OpenGL 3.0 came out it pretty much deprecated most of what GLu was based on. For example, the matrix stack was deprecated, and so GLu became pretty useless in a GL 3.x context.
I assume that GLU3 is the replacement for the original GLU, it looks like it has a load of math functions and replacement code for the deprecated matrix stack. This is really good news because I had to go out and develop my own math library ( http://www.kazade.co.uk/kazmath/ *) and this would have saved me that trouble
* Although if you are interested in it look at the bzr code in launchpad not the downloads
[quote]this would have saved me that trouble/quote]
Only if you have very low-end needs. I posted to Ian before about why his C++ wrappers are a bad idea (and yes, I am a C++ fan, not one of those C-only whiners) and why committing to that API is going to limit potential optimization work in the future. Plus the approach to including the C++ support by mixing the operator overloads right into the C struct is just bad.
For me personally (and Ian probably disagrees, and that's fine) I'd rather just see GLU disappear and see a nice open library (really open, not GPL) for high-end 2D/3D matrix math get endorsed instead. A library that is just a small core C API that can easily be heavily optimized with compiler vector intrinsics for x86/amd64/ppc/arm (all current compilers have a very hard time getting this right with C++ operator overloads, hence why it's not even worth it to support them). Give it all the usual 2D/3D matrix math along with the 3D projection calculation stuff, a matrix stack, etc. And yes, 2D is important. Most desktop apps are still 2D and even a lot of very popular games are entirely 2D (World of Goo comes to mind as one of the better examples, not to mention most of the handheld games), and 3x3 matrices take less space and time to use when you don't need the third dimension.
Most of the libraries out these that claim to fill that niche either suffer from severe feature creep, aren't portable, have alien API styles, are incomplete, or have offensive licensing.
I'd also really like to see a new GLUT that doesn't suck so hard. Something with an event loop the programmer actually has control over. I know we have SDL, but it has some other drawbracks regarding its other components (its input component causes issues on Windows with DirectInput and XInput, its audio system is borderline unusable, and its 2D drawing library literally _is_ unusable).


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At Phoronix we do not presently use Serious Sam 2 for benchmarking.
Quake 4 demos can be recorded using the command recorddemo <demo-name> and then to play the demo for benchmarking, timedemo <demo-name> can be used. For accurate results, it's recommended to run the demo at least twice.
At Phoronix with post-Quake 4 v1.2 the demo we use has been recorded Air Defense Bunker (the first map). Purification Center is another level we have used in the past for benchmarking.


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Physically, it looks imposing. If you fill the four holders with watches, most likely it will not move at all. If you fill three, it may move one side or the other, but the motor and drive mechanism is just too weak to move all four watches. IF I put one watch in one :drive: and one watch in the other "drive:, one size revolves and the other does not. But worst of all, the drive mechanisms are not silent. They are straining to operate properly and give off a whinning sound that will keep you up at night. In short, cheap is cheap. Buy the expensive German models and you will wind FOUR watches and be able to sleep as well. A totally unacceptable product by any measure.
Very poor quality construction, with no apparent factory quality control. The band, which the watch wraps around, was not the correct size to enable the watch to fit into the winder. The tray, where the watches sit on lifted up and off the winder when I went to take the watch off the winder. Very disappointed in the winder and very poor quality.
We had to return the original product because it was defective. It did not turn at all. We received the replacement very quickly.
it was sent without a power cord. once i received the power cord ,it worked fine.
Very well made, quality product. The internal timer is nice, and wood is very handsome.
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I agree with Craig....excellent looking crumb. Nice pie Brian. You said the char was too much....do you mean on the bottom? ' Cause the top looks good on this end.That's a great shot of Darwin!Best -k
Brian,Is that an inverted pie plate that you used to form the skin and, if so, was it to avoid having to measure the diameter of the skin?...Freezing the dough pretty much stops all biochemical activity. Peter
So am I right about taking the ball out several days in advance? If I can get some cold rise for flavor & color without blowing the dough, I'll be happy.


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AP Sportlight
Wednesday - 3/13/2013, 8:39am EDT
Compiled By PAUL MONTELLA
By The Associated Press
1944 -- In a tennis match to benefit wartime charities, amateur Jack Kramer beat pro champion Don Budge 6-3, 6-2.
1953 -- Seton Hall wins the NIT title with a 58-46 win over St. John's. Walter Dukes, who led Seton Hall with 21 points and 20 rebounds, finishes as the tournament's high scorer with 70 points and wins the MVP honors.
1954 -- Baltimore loses 65-54 at Milwaukee, giving the Bullets their 20th consecutive road loss for the season, and making them the first team in NBA history to go an entire season without winning a game on the road.
1960 -- Rookie Wilt Chamberlain scores a playoff record 53 points in Philadelphia's 132-112 triumph over the Syracuse Nationals to send the Warriors to the Eastern Division finals against the Boston Celtics.
1962 -- Detroit's Gordie Howe becomes the second player in NHL history to score 500 goals in the Red Wings' 3-2 loss to the New York Rangers.
1963 -- Guy Rodgers of the San Francisco Warriors hands out 28 assists in a 114-109 loss to the St. Louis Hawks, tying an NBA record set by Bob Cousy of Boston in 1959.
1965 -- Bill Russell of Boston scores 20 points and grabs 41 rebounds, and the Celtics set an NBA record with their 61st victory of the season, a 106-98 triumph over San Francisco.
1976 -- Bill Shoemaker posts his 7,000th career victory, aboard Royal Derby II, in the fifth race at Santa Anita Park.
1986 -- Edmonton's Paul Coffey has two goals and six assists to tie an NHL record for most points by a defenseman in a 12-3 rout of Detroit.
1987 -- Katarina Witt of East Germany wins her third world figure skating championship.
1987 -- Jockey Laffit Pincay Jr. becomes the first rider in the history of Santa Anita Park to win seven races in a single afternoon. In his only loss of the day, Pincay finishes third aboard Bob Back in the eighth race.
1997 -- Pittsburgh Penguins forward Joey Mullen becomes the first American-born player to score 500 career goals, with a goal in the second period against the Colorado Avalanche. The New York native is the 25th player in NHL history to reach the milestone.
1998 -- The Harvard women become the first 16th-seeded team, men or women, to win an NCAA tournament game by defeating top-seeded Stanford 71-67.
2004 -- Hermann Maier -- racing in his first full season since nearly losing his right leg in a motorcycle accident -- wins his fourth overall World Cup title. Maier also clinches the World Cup super-G title.
2008 -- Lindsey Vonn wins the overall World Cup skiing to complete the first American sweep of the men's (Bode Miller) and women's titles in 25 years. Vonn secures the title finishing tied for 11th in the giant slalom, the penultimate race of the season. It's the first time Americans took both titles since Phil Mahre and Tamara McKinney accomplished the feat in 1983.
2009 -- Miami's Dwyane Wade scores 50 points, grabs 10 rebounds and has nine assists in a 140-129, triple-overtime win over Utah.
2010 -- Kansas, Kentucky, Duke and Syracuse earn top billing and the No. 1 seeds for the NCAA men's basketball tournament. The Big East lead with eight teams, which ties its own record. It's the third time the conference has put that many teams in the tournament.
2012 -- Lindsey Vonn ends the women's World Cup downhill season in style by dominating the final race held in Schladming, Austria. The American overall champion, who had already won the downhill title, beats Marion Rolland of France by 0.92 seconds. It's Vonn's 12th win this season. Only Vreni Schneider of Switzerland won more races in one year -- 14 in 1988-89.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Immigration Policy & Law
Immigration Policy & Law
Recent Activity
After years of gridlock, increasing pressure from immigrant advocates, and several delays in 2014, President Obama announced sweeping executive actions to provide deportation relief to as many as 5.2 million unauthorized immigrants in the United States. The plan sparked a political firestorm among Republicans who vowed to use all tools at their disposal to block the actions, ensuring that immigration will continue to be a flashpoint for the remainder of the president's term.
Fears regarding the spread of the deadly Ebola virus following an outbreak in Guinea, Liberia, and Sierra Leone prompted governments around the world to regulate travel from and within West Africa. Travel bans, airport health screenings, closed borders, and traveler quarantines were among the policies implemented. International organizations argue such restrictions drive possibly symptomatic travelers to illegally bypass borders and encourage dishonesty in the exit screening process.
Mass cases of exploitation and abuse of migrant workers have drawn international scrutiny and criticism of the kafala system in Gulf Cooperation Council countries and private recruitment practices in Southeast Asia. With Qatar under scrutiny amid a frenzied construction boom in advance of the 2022 World Cup, international organizations and human-rights groups in 2014 stepped up their campaign for worker protection reforms.
Increasing numbers of Westerners heading to Syria and Iraq to join jihadist organizations like ISIS have governments concerned about possible attacks at home by returning fighters. Several thousand fighters from Europe and other Western countries are believed among the foreign nationals involved in conflicts in Syria and Iraq. Lawmakers scrambled in 2014 to respond with new policies, including seizing passports, stripping citizenship, and criminalizing travel to "no go" zones.
With a range of policies in 2014, China sought to address changing large-scale migration patterns within the country and beyond. This year included promises to reform the hukou registration system and thus enable an estimated 100 million internal migrants to access social services in the cities where they live, schemes to entice the return of emigrant professionals, and crackdowns on corrupt officials who send their families and money abroad.
U.S. Customs and Border Protection Commissioner R. Gil Kerlikowske, who assumed his duties in 2014, lays out his vision and discusses his priorities for the agency as part of MPI's Leadership Visions series.
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MPI researchers and representatives from London and Detroit discuss the policies and strategies used—at national and local levels—to attract immigrants into local economies.
This MPI panel discussion focuses on a toolkit by the Women's Refugee Commission to provide detained and deported immigrants as well as unauthorized immigrant mothers and fathers with crucial information to protect and maintain their parental rights and make well-informed decisions regarding the care and welfare of their children.
This MPI panel discussion examines the U.S. deportation system with analysis on migrant apprehensions, removals, returns, and criminal prosecutions, and launches the report, "The Deportation Dilemma: Reconciling Tough and Humane Enforcement."
A discussion with MPI experts of the less-examined aspects of President Obama's executive actions on immigration, with respect to immigration enforcement, legal immigration, and immigrant integration.
This conference, keynoted by USCIS Director León Rodríguez, featured panels on local immigrant integration policies; expected executive action on immigration; the treatment of unaccompanied children from Central America; and innovations in government-funded legal counsel and accelerated court cases.
MPI researchers, along with analysts from the Government Accountability Office and American Immigration Council, discuss the findings from an MPI report that examines the 3.7 million deportations that have occurred in the United States since establishment of the Department of Homeland Security in 2003, as well as lessons that can be learned for future policy and possible administrative action.
U.S. Customs and Border Protection Commissioner R. Gil Kerlikowske, who assumed his duties in 2014, lays out his vision and discusses his priorities for the agency as part of MPI's Leadership Visions series.
A discussion and report release on the Deferred Action for Childhood Arrivals (DACA) program, how its educational requirements may be impacting application rates, and recommendations for overcoming the education-success challenges that key subgroups of DACA-DREAM youth face.
This webinar covers key findings from MPI's report about the Deferred Action for Childhood Arrivals (DACA) initiative and eligible populations two years after its implementation, and also introduces MPI's data tool that provides national and state-level estimates of the current and potentially eligible DACA populations, as well as detailed profiles for the U.S. and 25 states.
This webinar exploring findings from MPI's report, Critical Choices in Post-Recession California: Investing in the Educational and Career Success of Immigrant Youth, which focuses on the implications of California's public education system reforms
A discussion of data compiled by MPI on "brain waste" among foreign-trained nurses, engineers, and teachers, with updates on three state-level initiatives—in Illinois, Massachusetts, and Washington State—that are working to analyze and address challenges faced by immigrants and refugees with degrees and training in these fields.
MPI experts, along with representatives from Gwinnett County Public Schools and the University of Georgia's Center for Latino Achievement and Success in Education, discuss the educational experiences of Georgia's first- and second-generation immigrant youth and where Georgia's ambitious education reforms have met—or failed to meet—the needs of this growing population.
MPI experts participate in a video chat shortly after the Migration Policy Institute released an analysis comparing the major provisions of the Senate bill to those of the individual House bills considered to date in House committees.
Recent Activity
While a number of major migrant-sending countries like Morocco and Turkey have started to take an active role in the integration of their migrants abroad, the role of subnational authorities has been overshadowed by diaspora engagement initiatives at the national level. This report investigates how the activities of origin countries' regional and local institutions may improve the lives of emigrants to Member States of the European Union.
While there is growing consensus on the value of immigrant integration support prior to departure, such initiatives generally have not fully realized their potential. This policy brief reviews promising examples of predeparture measures for labor market integration in Europe that are jointly designed and/or run by origin- and destination-country actors, illustrating their potential to help effectively address some of the most stubborn obstacles to successful integration.
Youth of a migrant background are over-represented among those who leave school early in the European Union. This policy brief discusses empirical findings, theoretical insights, and promising measures that may inform further policy action to address the disproportionately high level of early school leaving among students with a migrant background, which results from socioeconomic and other factors.
A number of actors outside the formal educational context, including parents, peers, and other community members, can play an important role in the social and educational development of migrant children. This policy brief reviews current measures to promote the integration of migrant students around Europe, focusing on those initiatives that include the family and community as part of the educational process.
A report release examining PIAAC data on the skills of U.S. immigrant adults and whether there is a gap with native-born adults, and discussion of how these skills relate to key immigrant integration outcomes such as employment, income, access to training, and health.
Immigrant adults in the United States lag their native-born peers in literacy, numeracy, and problem-solving skills, with resulting effects on their income, employment, education, and health, according to MPI analysis of U.S. scores on the 2012 Program for the International Assessment of Adult Competencies (PIAAC). The findings, which reveal wide ethnic and racial gaps in scoring, underscore deep U.S. social inequalities.
In a personal tribute published in the Migration Information Source, MPI's online journal, MPI President Emeritus Demetrios G. Papademetriou reflects on the life and career of Graeme Hugo, a world-renowned scholar and Director of the Australian Population and Migration Research Centre at the University of Adelaide, who died in January 2015.
Employment-oriented mentoring is increasingly recognized in Europe as a tool for advancing the labor market integration of disadvantaged individuals, including immigrants. This report highlights a number of relevant one-on-one mentoring practices in Europe and North America, focusing on the role of different initiators and stakeholders, forms of collaboration, methods, and target groups.


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In a cave an ancient and mysterious rite is about to be performed. Seven girls will be sacrificed to grant another life to the thousand-years-old alchemist Felix. Only the off-duty cop Paul and a deaf-mute teenager Lara could save them from that tragic fate.
I would define myself an incurable pragmatic person
I travel alone
I am god, do not dare menace me
After all, these are just seven drops in the ocean of time


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The Official Website of the Wotton-under-Edge Town Council May 5, 2015 |
Home | Contact Us | Map of the Town | How to Find Us | The Town Guide | Calendar & Diary | Links, Links, Links! | Weather Report Copyright © Wotton-under-Edge Town Council. All photos and maps are the copyright of the Wotton-under-Edge Town Council, except where otherwise stated, and may not be reproduced without permission. Please read our Terms and Conditions. |
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Final Sale
3/4 Sleeve Cutaway-Collar Jacket
Sorry, this product is sold out online!
Sold Out Online:
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- Shiny metal buttons
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- Patch pockets
- 25" Length
- 100% Polyester
- Dry clean.
- Imported
Item# 8715826
Love it, but...
I have no complaints about this jacket except that the color is listed as "navy" so I bought it with a pair of "navy" pants as suiting pieces and they do not match. I liked both items so opted to keep them and turn around and by the "navy" jacket that had been pictured with the pants, I just wish that the limited had designated the colors slightly differently since they do not match.
February 2, 2013
Great Basic
Purchased this blazer as I was looking for just a basic navy blazer to wear to work or with Jeans. Fits the bill on all levels.
January 3, 2013
Cute idea....
Not so much in execution. The jacket appears fitted through the waist, but in actuality it is very boxy. I am a curvy woman (bust, hips, backside) with broad shoulders and this jacket just made me look somewhat dowdy. IMHO this jacket would look better on a woman with less curves. It also was longer on me than it seemed it would be from the picture, and the sleeves were longer as well so it just didn't achieve the look I was going for. I do like the lapel, since I wanted this jacket to be more business casual to casual (jeans, nice blouse) and the gold buttons. I also like the weight of the jacket, very light and would work in winter, fall, and spring. The lining is fun too. I would definitely suggest trying this in person; as for myself I will just trade this in for some other Limited goodies :)
December 19, 2012
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Oral history with Ms. Zoya Zeman - Page 1 |
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Title | Oral history with Ms. Zoya Zeman |
Description | Oral history.; Interview conducted on April 18, 1996 with Zoya Zeman (born 1943). Ms. Zeman was a civil rights activist who worked on the Mississippi Summer Project in Clarksdale, where she worked at the community center, organizing classes and doing health education and literacy work. |
Date of interview | 18 April 1996 |
Interviewer | Rachal, John, 1948- |
Coverage (time period) | 1963-1964 |
Resource type | Text |
Format | Digital reproduction of a 33-page document. |
Language | English |
Publisher |
University of Southern Mississippi. Center for Oral History and Cultural Heritage. University of Southern Mississippi Libraries. (electronic version) |
Contributors | Electronic version made available through a National Leadership Grant for Libraries from the Institute for Museum and Library Services to the University of Southern Mississippi. |
Notes | This item is part of the Civil Rights in Mississippi Digital Archive. |
Rights | Copyright protected. Use of materials from this collection beyond the exceptions provided for in the Fair Use and Educational Use clauses of the U.S. Copyright Law may violate federal law. Permission to publish or reproduce is required. |
Contributing institution | Mississippi Oral History Program of the University of Southern Mississippi. |
Digital repository | University of Southern Mississippi Digital Collections. |
Digital collection | Oral History. |
File size | 280.244 KB |
File extension | |
Identifier | mus-coh.zemanz |
File name | mus-coh.zemanz.pdf |


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Ask D'Mine: Glucose Math and Insulin Home Economics
Happy Saturday, PWDs (people with diabetes)!
Welcome back to our weekly advice column, Ask D'Mine, hosted by veteran type 1, diabetes author and educator Wil Dubois. This week, we've got Wil humming that Rolling Stones tune Time Is On My Side as he answers a question about insulin activity and pre-bolusing for meals. Care to hum along as you take a read...?
{Got your own questions? Email us at email@example.com}
Susan, type 1 from…


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Stir It Up: Hanukkah, with an Italian accent
Hearty red wine turns a ho-hum pot roast into a Hanukkah-worthy feast. The photo is from "La Cucina Italiana: The Encyclopedia of Italian Cooking."It's common these days to give Hanukkah an "exotic" twist, such as Southwestern flavors or Asian ingredients. An Italian-ish Hanukkah is not much of a stretch. The classic dish from the Piedmont, Brasato al Barolo, is nothing but pot roast — but what a pot roast! The rich flavors turn it from ho-hum to Hanukkah-worthy.
The recipe here, from the spectacular "La Cucina Italiana: The Encyclopedia of Italian Cooking" (Rizzoli, 2012), can be adapted for a kosher meal — in which meat and dairy cannot mix — by simply substituting olive oil for butter. Barolo wine, the pride of the Piedmont, is too expensive for many of us to drink, let alone cook with; substitute another wine made with Nebbiolo grapes. Purists will holler, but inexpensive chianti works, too.
Jewish food writer Joan Nathan has speculated that the large population of Jews in the Piedmont region of Italy may have introduced almond biscotti to Eastern Europe, where the cookies became "mandelbrot" (almond bread). Thus, Italian baker Nick Malgieri's recipe for a biscotti made without butter or milk — known as cantuccini — makes a perfect Hanukkah dessert.
Round out the meal with escarole, green beans or other vegetables and, of course, polenta (made with water and cornmeal; no dairy). I couldn't find an Italian equivalent for latkes, the traditional pancakes for the Festival of Lights. Some things just don't translate.
Buon appetito!
Brasato al Barolo
Yield: 6 servings
8 whole cloves
2 medium yellow onions, peeled
1 stalk celery
2 carrots, halved
2 cloves garlic, crushed
Bouquet of parsley sprig, 1 fresh sage leaf, 1 bay leaf and rosemary sprig (see note)
6 whole black peppercorns
Pinch fine sea salt
Pinch ground cinnamon
Pinch freshly grated nutmeg
1 boneless beef chuck roast, about 2 pounds
1 (750 ml) bottle Barolo or other red wine
1 tablespoon unsalted butter (or olive oil)
1 cup brandy
Stick 4 cloves into each of the onions and place in a large, nonreactive bowl with celery, carrots, garlic, bouquet, peppercorns, salt, cinnamon and nutmeg. Place the meat in the bowl and pour the wine over. Cover bowl with plastic wrap and refrigerate at least 6 hours, preferably overnight.
Remove meat from the marinade. Reserve the marinade; pat the meat dry. Heat butter (or oil) over medium-high in a Dutch oven with a tight-fitting lid. Pour brandy over the meat, then quickly (and carefully) touch a lit match to the surface of the meat.
When the alcohol burns off, strain the marinade and add the strained liquid, onions, celery, carrots, garlic and bouquet to the pot. Cover and cook over very low heat until the meat is tender, about 4 hours. Remove meat from the pot and set aside. Remove cloves from the onions and discard. Discard the bouquet. Working carefully (it will spurt), puree cooking liquid and vegetables in a food processor or blender. Return the puree and the meat to the pot. Heat gently 10 minutes. Carve and serve, with the sauce.
Note: To make the bouquet, tie together the herbs with cotton twine, or wrap in cheesecloth and tie.
Recipe from "La Cucina Italiana: The Encyclopedia of Italian Cooking," by the editors of La Cucina Italiana magazine (Rizzoli, 2012)
Yield: 6 to 8 dozen
2 cups all-purpose flour
¾ cup sugar
2 teaspoons baking powder
½ teaspoon cinnamon
¼ teaspoon salt
1½ cups whole almonds
3 large eggs
2 teaspoons pure vanilla extract
Position a rack in the center of the oven and preheat oven to 350 degrees. Line a cookie sheet with baking parchment.
Combine flour, sugar, baking powder, cinnamon and salt in a large bowl. Stir in almonds. Whisk together eggs and vanilla in a small bowl, then stir them into the flour mixture. The dough may seem dry, but it will come together as it is kneaded.
Turn out the dough onto a lightly floured surface and knead until it holds together, 1 to 2 minutes. Divide dough in half and shape each half into a log that is 12 inches long, 2 inches wide and 1 inch high. Transfer both logs to the lined pan. Bake 30 minutes, or until firm to the touch. Slide the logs, parchment and all, onto a wire rack. Cool completely. At this point, you can keep the logs for several days, wrapped in plastic.
Preheat oven to 350 degrees. Line 2 cookie sheets with parchment. Working with a sharp serrated knife, cut the cooled logs diagonally into ¼- to 3/8-inch slices. Bake 10 to 15 minutes, or until crisp and golden. Cool and store in an airtight container up to 1 month.
Recipe from Nick Malgieri, printed in "Baking With Julia," by Julia Child (William Morrow, 1996)
Marialisa Calta is a syndicated food writer who lives in Calais.MORE IN Food & DiningMy 16-month-old daughter has started identifying her favorite fruit, joyfully crying ba-NA-na! ... Full StoryAs a mom, I know theres no better gift on Mothers Day than being served breakfast in bed,... Full Story -
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Market View: A Glimpse Into the Future Employees of America
What I've learned about this next generation of food and beverage marketers.
01/28/2015Food Ingredients That Prevent Cognitive Decline
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01/26/2015Top 10 Reasons to Attend The Food Leaders Summit 2015 this April
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text:
Moto3 pre-season testing at the Ricardo Tormo circuit in Valencia continued with teams making the most of slightly warmer temperatures during the second day of their first test of 2012.
German rider Sandro Cortese of the Red Bull KTM Ajo team was again fastest on the Valencia circuit on Thursday when Moto3 teams gathered for the second of three days of tests. He registered the fastest time again of the field, a 1:41.3 best time and an improvement of three tenths over Wednesday's top time.
Alberto Moncayo of Spain on the KALEX-KTM followed just one tenth behind the German, and commented "if we continue to progress as we are, we'll do well the rest of the year. Today was good because I felt comfortable from the third lap on."
Briton Danny Kent was two-tenths behind his Red Bull KTM Ajo teammate Cortese to rank third, while one of the season's favorites in the new category of Moto3, Hector Faubel, finished fourth, four-tenths off Cortese and seven tenths quicker than his best effort yesterday.
Faubel was also positive, saying that the day had been very productive. "Overall I am very pleased that we got in a quick lap this morning even though the track was very cold. We're collecting a lot of good data and making some fast improvements."
The second day saw KTM riders take six of the top ten positions, an indication that the Austrian brand is looking promising for its re-entry into mainstream MotoGP competition in this new category.
There was a combined session on the circuit for the Moto2 and Moto3 bikes from ten till three o'clock, and then one hour especially for each class. The Moto3 riders were the last ones out on the second day.
Unofficial Moto2 lap times Thursday (recorded by teams)
1. Sandro Cortese (D), Red Bull KTM Ajo, 1'41.3 (KTM, 52 laps)
2. Alberto Moncayo (E), Aspar Team Moto3, 1'41.4 (KALEX-KTM, 42 laps)
3. Danny Kent (GB), Red Bull KTM Ajo, 1'41.5 (KTM, 56 laps)
4. Hector Faubel (E), Aspar Team Moto3, 1'41.8 (KALEX-KTM, 34 laps)
5, Miguel Oliviera (E), Oliviera Monlau, 1'41.8 (61 laps)
Other KTM
6. Zulfahmi Khairuddin (MA), Airasia-SIC-Ajo, 1'42.4 (KTM, 33 laps)
10. Brad Binder (RSA), RW Racing GP, 1'43.3 (KALEX-KTM, 41 laps)
14. Arthur Sissis (AUS), 1'44.5 (KTM, 55 laps)


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Doris Meissner Testimony Video: Border Security
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Boogieman Candy Costume Dracula Ghost Gobblin |
Halloween Haunted Howl Mask Moonlight Monster |
October Pumpkin Spooky Scary Trick Treat |
Vampire Witch |
How to Play:
At the top of each game is a grid with two rows of letters. All of the letters of the alphabet are set out in the first row of the Secret Decoder. The second row of letters is the key. Use the key to unscramble the Halloween words.
An example of one decoder key might be:e=tThe word unscrambled would be "treat."
There is a different decoder key for each game. A word list is provided for every game to help you out.
To print the games to play off-line, first choose a game and allow it to fully load in your web browser. Then, from the upper left corner of your web browser, click on "File" then "Print" or follow your web browser's directions on how to print a web page. Have fun!
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2007 BV - Cabernet Sauvignon Clone 6 Cabernet Sauvignon - USA - California - Napa - Rutherford - Red
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Producer NotesIn 1900, when Georges de Latour's wife, Fernande, first laid eyes on the land that would become their original Rutherford vineyard, she named it "beau lieu," or "beautiful place." Shortly thereafter, de Latour sold his thriving cream of tartar business, bought the four-acre ranch and founded Beaulieu Vineyard with the vision of making Napa Valley wines that would rival those of his native... More » |


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Lawyer says Northern Pass in 'a corner'
Jack Savage, spokesman for the forest society, said the passage through the conservation area separating the two Northern Pass parcels is "a very short distance." Northern Pass partners may not have even realized the two parcels did not abut when they were purchased, he said.
Savage said the forest society obtained the legal opinion and posted it now as a preemptive strike to an anticipated request from Northern Pass to DRED for a right of way, either above or under ground.
"If you look closely at the map, it's their only option to make use of the $40 million they have spent on an intended route," he said. "It's the only possible way they can get out of the corner they painted themselves into."
Masland acknowledges that a section of the deed outlining the rights of the easement holder states that "No rights of way ... utility lines or other easements shall be constructed .. on, over, under or across the property without the prior written permission of the easement holder."
Since one of the purposes is "benefit of the general public," that could be interpreted to mean almost anything.
"We can say, however, that our new route was specifically designed to address the visual impact concerns with our original proposal," he said. "We have always maintained that any new proposal will be respectful of property rights, legal restrictions, or easement agreements governing the land we are seeking to use."
The Forestland Group would not comment on whether a request for an easement by Northern Pass had been received or discussed.


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Object Description
Title | A history of the Tennessee Industrial School |
Author | Harris, Kenneth LeRoy |
Date | 1953 |
Coverage |
19th century 20th century |
Publisher | Middle Tennessee State University |
Place of Publication | Murfreesboro, TN |
Description | A history thesis submitted to the Faculty of the College of Graduate Studies in partial fulfillment of the degree of Master of Arts |
Abstract | Study in the area of the Social Sciences, and particularly in that of Sociology, caused the investigator to become interested in the Tennessee Industrial School, at Nashville, Tennessee. It is an institution for the specific benefit of orphaned, helpless, and indigent children. It was apparent that a difference of opinion was in existence regarding the purpose of the Tennessee Industrial School. Many institutions, founded on the same principles and for the same purposes as the Tennessee Industrial School, arose in the earlier days of our country, based upon the philosophy that bad children can be indoctrinated with virtues through a program of academic education, or through the inculcation of "habits of industry" by way of vocational training or productive work... |
Physical Description | 156 leaves : typed, tables ; 28 cm |
Series | History Department, M.T.S.U. |
Subject-LCSH |
Nashville (Tenn.) -- History Private schools -- Tennessee |
Type | Text |
Format | application/pdf |
Genre | Thesis |
Medium | Paper |
Extent | 164 p |
Language | eng |
Copyright Status | Copyright protected. Reproduced with permission of the author. |
Conditions for use | Copyright maintained by author. Academic and personal use only. |
Contributing Institution | James E. Walker Library, Middle Tennessee State University |
Digital Publisher | Digital Initiatives, James E. Walker Library, Middle Tennessee State University |
Source file | ht_harris.pdf |