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The coolest, high quality, All-American lifestyle clothing for every guy and girl.
See all things: abercrombie Children's & Infant Fashions
Abercrombie & Fitch focuses on providing high-quality merchandise that compliments the casual classic American lifestyle.
See all things: Abercrombie & Fitch Women's Fashions Men's Fashions Men's & Women's Fashions
A popular shopping destination for today's teenagers, Aéropostale is a leading mall-based specialty retailer that designs, markets and sells its own brand of casual, current apparel targeting 14 to 18 year-olds...
See all things: Aeropostale Women's Fashions Men's Fashions Men's & Women's Fashions
Aldo Shoes is an upscale shoe store with offerings for both men and women.
See all things: Aldo Shoes Shoes & Footwear
AE brings you high quality, on-trend clothing, accessories and personal care products at affordable prices. AE's collection includes modern basics like jeans, surplus and graphic tees as well as a stylish...
See all things: American Eagle Outfitters Women's Fashions Men's Fashions Men's & Women's Fashions
Some people desire to own unique jewelry that can't be found in the average jewelry store. Or maybe you have existing jewelry that you would like to have restyled. We love to make fun and original jewelry and to help in...
See all things: Andrews Jewelers Jewelry & Watches
For more than a century, AT&T has provided consumers with innovative, reliable wireless products and services. Whether you're shopping for the next generation phone, a digital TV package, or broadband Internet service for...
See all things: AT&T Mobility Accessories Services Electronics & Technology
Auntie Anne's provides 11 varieties of hot, fresh pretzel products, in sweet and zesty flavors. It's only natural to want to try one! And nothing goes better with your pretzel than one of our dips and our Old Fashioned...
See all things: Auntie Anne's Pretzels Restaurants (order at the counter)
Bamboo Traditions is committed to being green, not only do we start all of our products with bamboo but on the inside of each pillow you will find recycled memory foam. At each step Bamboo Traditions is preserving the...
See all things: Bamboo Pillows Home Furnishings Home Decor
The True Outfitters of Modern American Style, Banana Republic brings a fresh twist on classic apparel to men and women around the world. The company that started as a safari outfitter in San Francisco now outfits a whole...
See all things: Banana Republic Women's Fashions Men's Fashions Men's & Women's Fashions
Visit the newly-remodeled store on the Lower Level for a full selection of health and beauty specialities including product lines from Caudile, Molton Brown, Murad and Warren Tricomi.
See all things: Bath & Body Works Flagship Specialty Shops Health, Bath & Beauty
Bath & Body Works is the apothecary of the 21st century. It is the authority dedicated to helping people find their own individual paths to well-being by bringing them the very best personal care products the world has to...
See all things: Bath & Body Works Upper Level Specialty Shops Health, Bath & Beauty
Welcome to the perfect solution for your bathroom remodeling plans. BATH FITTER® is North America's premier manufacturer of acrylic bathtub liners, walls and shower bases. BATH FITTER®has the perfect solution for your...
See all things: Bath Fitter Home Furnishings
Best Buy Mobile carries all the major brands on all the major carriers. Our Mobile Consultants would be happy to explain the difference in plans, prices, and features to get you the best phone on the best plan for you. ...
See all things: Best Buy Mobile Specialty Shops Electronics & Technology
Food Court vendor offering delicious cajun entrees with a mix of rice, beans, vegetables, potatoes, chicken and more. Our customers love the bourbon chicken, blackened fish and garlic pasta.
See all things: Big Easy Cajun Restaurants (order at the counter)
"Welcome to BJ's." This is how you are greeted when you come into our welcoming, caring, dependable, high-energy and fun casual restaurants, and we promise to do whatever it takes to serve high-quality food and beverages...
See all things: BJ's Restaurant and Brewhouse Restaurants (order via wait staff)
Piercing is also available. Come check us out!
See all things: Body Jewel Jewelry & Watches
Famous for creating a niche market sector for naturally inspired skin and hair care products, The Body Shop introduced a generation of consumers to the benefits of a wide range of best sellers from Vitamin E Moisture...
See all things: Body Shop, The Specialty Shops Health, Bath & Beauty
See all things: Bowtique Accessories
Beautiful gifts, jewelry, crystal ornaments and more!
See all things: B.R. Gifts Jewelry & Watches Cards, Books, Gifts & Stationery
From the start Brookstone wanted to create a fun, interactive shopping experience. At our stores, customers are encouraged to try products out for true, hands-on shopping. Every visit to Brookstone is an opportunity to...
See all things: Brookstone Home Furnishings
Introducing Brothers, a new clothing line for boys from the same people who brought you Justice clothing for girls.
See all things: Brothers Children's & Infant Fashions
An expanded Buckeye Room is open on the Lower Level at the Mall at Tuttle Crossing, offering a HUGE selection of sports apparel,memorabilia and collectibles from The Ohio State University Buckeyes. We also have a great...
See all things: Buckeye Room, The Sporting Goods & Athletic Wear
Your Favorite Fit: Personal Denim Fitting Contact the store to set up an appointment to have a denim specialist find your favorite denim fit.
See all things: Buckle Women's Fashions Men's Fashions Men's & Women's Fashions
Visit Build-A-Bear Workshop® a beary special place where you make your own stuffed animal! Make your furry friend unique with hundreds of fashions and accessories. We do parties too!
See all things: Build-A-Bear Workshop® Entertainment Toys, Games & Hobbies
Experience the brand that loves your curves! Cacique, an exclusive collection of perfect-fitting bras, panties, and more, that was created to love and understand curves every time.
See all things: Cacique Women's Fashions
Features cell phone and electronic device covers and cases in a variety of colors and styles.
See all things: Cellairis Music & Movies
A fun variety of cell phone cases and accessories are available at this kiosk on the Lower Level.
See all things: Cell Fashion Accessories Specialty Shops
We've been perfecting our craft for over 25 years. So trust us, we know a thing or two about giving you the best Philly Steaks on the planet. In fact, every Philly Steak we serve is made with 100% USDA Choice Steak, 100%...
See all things: Charleys Philly Steaks Restaurants (order at the counter)
Retail chain carrying trendy clothing, shoes, intimate apparel & accessories aimed at young women.
See all things: Charlotte Russe Women's Fashions
Cheryl's buttercream icing is famous!Try some of our buttercream frosted cookies today and see for yourself why people love these cookies so much!Weekly Specials:Mondays choose any 2 brownies + 4 cookies for only...
See all things: Cheryls Specialty & Gourmet Foods
Our sandwiches, salads, Cool Wraps®, Chick-fil-A Chick-n-Strips® and nuggets are made with 100% tender chicken. Side items with a delicious Chick-fil-A® twist (Waffle Potato Fries™, anyone?). Rich desserts. Even Lemonade...
See all things: Chick-fil-A Restaurants (order at the counter)
THE CHILDREN'S PLACEVALUE EVERY MOMENTchildrensplace.com
See all things: Children's Place The Children's & Infant Fashions
Chilitos is a fast casual Mexican restaurant, using the freshest ingredients in all meals. Giving you the choice to build your own dish to your own taste.
See all things: Chilitos Fresh Mex Restaurants (order at the counter) Restaurants (order via wait staff)
Christopher & Banks is a specialty retailer of women's casual apparel that offers exclusively designed, private-label, coordinated women's clothing in missy sizes 4 to 16 and petites 4P to 16P (in select markets and...
See all things: Christopher & Banks Women's Fashions
Claire's Stores, Inc. is a leading international specialty retailer offering value-priced costume jewelry, accessories and cosmetics to fashion-aware tweens, teens and young adults.
See all things: Claire's Accessories
The newest addition to The Gymboree Corporation's family of brands, Crazy 8 offers fashionable outfits at a great value for girls and boys sizes Newborn to 14. The first Crazy 8 store opened in August 2007, and The...
See all things: Crazy 8 Children's & Infant Fashions
Cricket Communications is the affordable wireless carrier, with great deals on cell phones and cell phone plans. Unlike most other cell phone companies, Cricket offers everything unlimited. Unlimited local calling...
See all things: Cricket Wireless Services
The Dakota Watch Company has been in the watch business since 1945. With over 200 watch stores in regional malls, we have grown to be one of America's largest watch retailers. Dealing directly with over three million...
See all things: Dakota Watch Company, The Jewelry & Watches Accessories
Find a dentist: To schedule a dental care appointment with your Tuttle Crossing Mall dentist on Tuttle Crossing Blvd. today, call (614) 791-1939; after hours call . Monday, Wednesday — Tuesday, Thursday — Friday...
See all things: DentalWorks Services Medical
In our selection of beautiful diamond, silver, gold, and precious jewelery, you are sure to find something you'll enjoy! We have a wide variety including engagement rings, wedding bands and earrings.
See all things: Diamonds Forever Jewelry & Watches
Featured products include: Dippin Dots Ice Cream Dots N Cream (regular hand dipped ice cream with a hint of dots inside) All Dots N Cream flavors are available in a sugar cone, waffle cone, waffle bowl or a cup. Dots...
See all things: Dippin' Dots Specialty & Gourmet Foods Restaurants (order at the counter)
Great dress and party styles for everyone with any occasion!
See all things: Dress & Party Men's & Women's Fashions
ecoATM is the first and only company to create an automated self-serve kiosk system that uses patented, advanced machine vision, electronic diagnostics, and artificial intelligence to evaluate and buy-back used...
See all things: ecoATM Electronics & Technology
Fresh Greek meals at your service.
See all things: Evropi Restaurants (order at the counter)
Express is the must-have sexy, sophisticated fashion brand for work, the weekend, or going out. It's what's new and what's now for young fashion-forward women and men. We started more than thirty years ago as an...
See all things: Express Women's Fashions Men's Fashions Men's & Women's Fashions
The latest looks for work and weekend with tees, jackets, jeans, polos, shorts & more.
See all things: Express Men Men's Fashions Accessories
Put your best face forward with Eyebrowz. Visit our salon for eyebrow shaping, tinting and enhancements. Say goodbye to daily mascara…. we also do eyelash tinting! Eyebrowz is also a full-body waxing salon. And don't...
See all things: Eyebrowz Health, Bath & Beauty
Farah Jewelers offers an extensive collection of loose diamonds from all around the world. All of our diamonds have been obtained through ethical means and comply with the current standards set forth by the Kimberly...
See all things: Farah Jewelers Jewelry & Watches Accessories
For the most unique looks in evening and formal wear, visit the City! Fashion City has everything from precious dresses for little ones to prom wear, bridal fashions, and evening gowns. Stop in and leave looking fabulous!
See all things: Fashion City Accessories
We repair phones, i-phones, i-pads, smart phones and much more. Order new screens, covers and other accessories.
See all things: Fast Repair Electronics & Technology
Trendy and affordable women's clothing & accessories!
See all things: Figleaf Women's Fashions Accessories
Finish Line is a leading athletic retailer offering the best selection of brand name footwear, apparel and accessories. The company operates more than 660 stores in 47 states and online at www.finishline.com. We...
See all things: Finish Line Shoes & Footwear Sporting Goods & Athletic Wear
Foot Locker is the world's leading retailer of athletic footwear and apparel. Headquartered in New York City, it operates approximately 3,900 athletic retail stores in 17 countries in North America, Europe and Australia.
See all things: Foot Locker Shoes & Footwear Sporting Goods & Athletic Wear
At Forever 21, style isn't dictated…It's inspired. Forever 21 is the leading fashion retailer of the latest trends and the season's hottest styles at can't-resist-prices. U.S. and international locations stay true to the...
See all things: Forever 21 Women's Fashions Men's & Women's Fashions Children's & Infant Fashions Accessories Women's Specialty
The Fox Sports Ohio Blue Line is the official team store for the NHL's Columbus Blue Jackets. We are your one-stop shop for gifts, novelties, men's, ladies, and kids' apparel. Tickets are also available for purchase for...
See all things: Fox Sports Ohio Blue Line Sporting Goods & Athletic Wear Specialty Shops
We are located on the Lower Level near Center Court... come visit!
See all things: Francesca's Collections Jewelry & Watches Women's Fashions Accessories
Have a sweet tooth that can't be satisfied? You need to visit Fuzziwigs! From sours to chocolates, they have everything. Looking for a candy color scheme for your wedding or party candy bar? Look no further! Choose...
See all things: Fuzziwigs Candy Factory Specialty & Gourmet Foods
FYE For Your Entertainment- music, movies, games, CDs, DVDs, the latest hits, deep classics, rare imports, box sets, limited editions...all the entertainment you love.
See all things: fye - For Your Entertainment Entertainment Music & Movies
Gap Inc. is a leading global retailer offering clothing, accessories and personal care products for men, women and children under the Gap, Banana Republic, Old Navy, Piperlime, Athleta and Intermix brands. Gap Inc...
See all things: Gap Women's Fashions Men's Fashions Men's & Women's Fashions
Jewelry and accessories at prices to fit any budget.
See all things: Glitter Accessories Specialty Shops
GNC sets the standard in the health and nutrition industry by demanding truth in labeling, ingredient safety and product potency, all while remaining on the cutting edge of nutritional science. General Nutrition Centers...
See all things: GNC Specialty & Gourmet Foods Health, Bath & Beauty
Godiva was first to create the concept of premium chocolate. We did this by combining a fabulous product, stimulating advertising, sophisticated packaging and selective distribution. Godiva's standards of excellence...
See all things: Godiva Chocolatier Specialty & Gourmet Foods
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See all things: Go! Games Toys, Games & Hobbies
Gymboree® Unique from head to toe. Girls and boys clothing and accessories for newborns, toddlers and children up to size 12.
See all things: Gymboree Children's & Infant Fashions
At Hallmark, we're all about celebrating all of those perfectly imperfect moments shared in between the milestones. We're about real life – not an ideal life. And spontaneous moments that can happen on holidays or any...
See all things: Hallmark Cards, Books, Gifts & Stationery
Since 1915, Helzberg Diamonds has helped people celebrate their most heartfelt and meaningful occasions. Founded on a commitment to superior customer service, we offer a dazzling selection of fine jewelry – so you're...
See all things: Helzberg Diamonds Jewelry & Watches
H&M is one of the worlds leading fashion retailers, offering our customers fashion and quality at the best price. We offer a wide range of clothing, with everything from basics to the latest fashion trends. With new items...
See all things: H&M Women's Fashions Men's Fashions Men's & Women's Fashions Children's & Infant Fashions
Hollister Co. is the newest southern Cali lifestyle retailer geared towards energetic and outgoing guys and girls. Continuing to paddle to the top, Hollister's leading the way with our hip, casual, and trend setting...
See all things: Hollister Co. Women's Fashions Men's Fashions Men's & Women's Fashions
Do you have a passion for music, pop culture and music-inspired fashion? Hot Topic does. From the merchandise assortment to the staff to the exclusive in-store events and artist appearances - walk into any Hot Topic store...
See all things: Hot Topic Men's & Women's Fashions Specialty Shops Teen's Fashions
Basketball Shoes, Casual Shoes, Sneakers, Running Shoes - New Releases & Exclusive Styles from Jordan, Nike, adidas, Under Armour & more.
See all things: House of Hoops Shoes & Footwear Sporting Goods & Athletic Wear
One stop shop for great hair straighteners.
See all things: Hs Evolution Health, Bath & Beauty
Must have accessories and jewelry for the "it" girl. Make sure to visit ICING for all your fabulous accessorizing needs!
See all things: Icing Accessories
About JCPenney: JCPenney, one of the nation's largest apparel and home furnishing retailers, is dedicated to fitting the diversity of America with unparalleled style, quality and value. Across approximately 1,100 stores...
See all things: jcpenney Department Stores & Anchors
Our Optical Department provides you with a selection of specialty lenses. If your need is UV protection, anti – reflective options or lightweight lenses, we can fit you with the newest advancements in lens treatments. Eye...
See all things: JCPenney Optical Department Stores & Anchors Services Health, Bath & Beauty Sunglasses, Optical & Eyewear
jcpenney Portraits is an all-occasion portrait studio designed to provide high-quality portrait products for customers' needs. jcpenney Portraits provides portrait services for all occasions: newborn, birthday, first...
See all things: JCPenney Portrait Studio Services Photography & Printing
Designer frangrances and fashionable jewelry!
See all things: Jewelry & Perfume Jewelry & Watches
Journeys is a destination retailer of shoes and accessories for diverse, young, 13-22 year old guys and girls in search of footwear that expresses their unique attitudes and lifestyles. Journeys offers a wide variety of...
See all things: Journeys Shoes & Footwear Men's Fashions Men's & Women's Fashions Sporting Goods & Athletic Wear
Launched in 2001 as an extension of the highly successful Journeys store, Journeys Kidz is a unique branded kids' footwear retailer, targeting customers 5 to 12 years old who like trendy shoes and accessories, including...
See all things: Journeys Kidz Shoes & Footwear Children's & Infant Fashions
Justice is the coolest place for young girls to find everything bright, fun, and trendy to create her own unique look. From accessories to entire outfits, your pre-teen will love shopping at this store!
See all things: Justice Children's & Infant Fashions
Every diamond is hand-selected to match beautifully and must pass exacting quality standards. Kay is diligent about the quality of our craftsmanship. We take the time to ensure the diamonds in your jewelry are well...
See all things: Kay Jewelers Jewelry & Watches
Kids Foot Locker offers parents a place where they can get the largest selection of quality athletic footwear, apparel and accessories for their children, as well as, expert advice that will meet or exceed their child's...
See all things: Kids Foot Locker Shoes & Footwear Children's & Infant Fashions Sporting Goods & Athletic Wear
With Lands' End shops in Sears® stores around the country' shopping for our high-quality products in person has never been easierThey carry a wide range of products, and customers can shop our full selection of...
See all things: Lands' End Shop at Sears Women's Fashions Men's Fashions Men's & Women's Fashions Accessories
As the leading fashion brand for curvy women, Lane Bryant continually strives not only to be first in fashion and fit, but to be everywhere, be everything you expect us to be. From clothing and accessories to our...
See all things: Lane Bryant Women's Fashions Accessories Specialty Shops Women's Specialty
One of the leading manufacturers in granite and cabinetry work in central Ohio.
See all things: L & E Kitchen Supply Services Home Decor
LensCrafters was the first company of its kind to offer the convenience of getting an eye exam and choosing stylish frames fitted with the latest high tech lenses in one location. Same day services available.
See all things: LensCrafters Services Sunglasses, Optical & Eyewear
A blast from the past! Check out our amazing collection of original Nintendo and Atari games.
See all things: Level 1 Games Entertainment Toys, Games & Hobbies
The best selection of sport, fashion and collegiate hats in the latest designs and trends. Choose hats from the hottest brands and profiles, with the accessories and apparel you need to complete your look.
See all things: Lids Accessories
The Limited is vibrant, feminine, sophisticated style for the modern fashion-forward woman. The Limited provides the modern, young woman fashion that reflects her up-to-the-minute sense on style. Inspired by the latest...
See all things: Limited, The Women's Fashions
Macy's has an assortment of merchandise that includes home furnishings, luggage, men's and women's fashions, junior and children fashions, shoes, cosmetics, fashion accessories and fine jewelry.
See all things: Macy*s Hayden Run Department Stores & Anchors
Macy's has an assortment of merchandise that includes home furnishings, luggage, men's and women's fashions, junior and children fashions, shoes, cosmetics, fashion accessories and fine jewelry.
See all things: Macy*s Tuttle Crossing Department Stores & Anchors
The management team at the Mall at Tuttle Crossing is here to help you have a pleasant shopping experience. If you find something at the mall that is not to your liking, that you think can be better, or even that you...
See all things: Mall Management Office Services
The friendly security staff at the Mall at Tuttle Crossing is here to make your shopping experience a pleasant and safe one. Look for security in the Mall in their white and black uniforms, or call them at (614) 717-9630.
See all things: Mall Security Services
MasterCuts is a casual, upbeat salon that offers cool, classic looks for the whole family. All at practical prices. Conveniently close, we're right here in your neighborhood mall. Since our services are individually...
See all things: MasterCuts Services Health, Bath & Beauty
Beautiful Art at Masterpiece Gallery
See all things: Masterpiece Gallery Arts & Crafts
The Menchie's Private Label Collection is made exclusively with our own custom blend of flavors that you won't find anywhere else. We strive to offer something for every guest and pride ourselves on using only the highest...
See all things: Menchie's Frozen Yogurt Specialty & Gourmet Foods
Designer, brand name and private label men's tailored suits, sport coats, slacks, shoes, furnishings and accessories at prices 20 to 30 percent below major department stores and specialty retailers.
See all things: Men's Wearhouse Men's Fashions
From sportswear to suits to tuxedos, Men's Wearhouse and Tux® offers the styles and personalized service that has helped men look their best for the last 35 years. Our helpful Wardrobe and Formalwear Consultants are...
See all things: Mens Wearhouse Tux Men's Fashions Men's Specialty
Miracle Eyebrows helps people realize their aspiration to beauty and enables them to express their personality, gain self-confidence and rejuvenate their mind, body and soul. We offer experts of natural hair...
See all things: Miracle Eyebrows Health, Bath & Beauty
Full service nail spa: manicures, pedicures, acryllic & airbrushing
See all things: Modern Nails Services Health, Bath & Beauty
Moochie & Co. consistently looks for new pet products that are functional, well made, creatively designed, and offer great value. Moochie & Co. has the stuff dogs and cats love. And some pretty cool stuff for people who...
See all things: Moochie & Co. Specialty Shops Cards, Books, Gifts & Stationery
Full service nail salon offering manicures, pedicures, acrylic nails, polish and more.
See all things: Nail Experts Services Women's Specialty Miscellaneous
New Balance is the only athletic shoe manufacturer still making shoes in the . 25% of New Balance shoes sold domestically are produced by our workforce, using US and imported materials.
See all things: New Balance Shoes & Footwear Sporting Goods & Athletic Wear
Great style. Great value. Always sexy. New York & Company is a lifestyle brand: the clothes are modern and trendy; the prices are affordable. New York & Company is available exclusively in our own stores. That's a...
See all things: New York & Company Women's Fashions
Our dishes are prepared fresh daily with the finest ingredients. Our Japanese recipes are developed by master chefs with care to deliver the highest quality and authenticity. Nori Japan provides a full range of Japanese...
See all things: Nori Japan Restaurants (order at the counter)
An Ohio sports' fan paradise! Love the Bengals, the Browns, or the Buckeyes? This is the place for you. Everything you need to celebrate your fandom, from apparel to party supplies, the straight forward to the sublime.
See all things: Northern Sports Sporting Goods & Athletic Wear Miscellaneous
Your favorite skin and hair care line has a new home in the Mall at Tuttle Crossing. Come visit us at a new Macy's!Origins is now located in Macy's at Tuttle Crossing near Panera Bread and Moochie & Co.
See all things: Origins at Macy's Tuttle Crossing Specialty Shops Health, Bath & Beauty
PacSun offers a wide selection of casual apparel, footwear and accessories for young guys and girls inspired by the California lifestyle. From boardshorts and t-shirts to jeans and hoodies, you can't go wrong anytime of...
See all things: PacSun Women's Fashions Men's Fashions Men's & Women's Fashions Accessories Specialty Shops
From its beginning PANDORA jewelry was created with the customer in mind. The company offers versatile, sophisticated pieces-charm bracelets, rings, necklaces and earrings – in 14K gold, sterling silver and some with...
See all things: Pandora Jewelry & Watches Accessories
Check out our Via Panera catering for your next event.
See all things: Panera Bread Restaurants (order at the counter)
High fashion shoes without the high price. Find shoes for every occasion, season and reason . . .including wide widths and hard-to-find sizes!
See all things: Payless ShoeSource Shoes & Footwear
We offer great deals on designer frames, quality lenses, and contacts.Walk-in eye exams are often available. We accept many insurance plans - call us to find out if we take yours.We have a great selection and great staff...
See all things: Pearle Vision Services Sunglasses, Optical & Eyewear
Perfumania, America's Leading Perfumery Chain, is where you can find all of your favorite designer fragrances at up to 50% Off Department Store Prices
See all things: Perfumania Specialty Shops Health, Bath & Beauty
A small business that specializes in gourmet popcorn flavors. We offer 20 different flavors made fresh daily and host a variety of services. We offer retro candy and many gift ideas.
See all things: Popcorn Junkey Restaurants (order at the counter)
Heal and prevent acne with the proven acne treatment system. Proactiv Solution can restore your healthy skin and prevent future breakouts. 1-877-275-2561 extension 3292
See all things: Proactiv Specialty Shops Miscellaneous
Pronounce Activewear premier boutique was created to provide our communities and customers with premium men's and women's yoga & activewear.
See all things: Pronounce Activewear Sporting Goods & Athletic Wear
rue21 is a leading specialty retailer offering the latest fashion for girls and guys. We continue to strive for the best selection while offering a competitive pricing strategy. As new goods arrive daily, our choices of...
See all things: rue21 Women's Fashions Men's Fashions Men's & Women's Fashions Accessories
Sears' stores sell apparel, tools, and appliances, as well as providing home services (remodeling, appliance repairs) under the Sears HomeCentral brand. Sears is the leading home appliance retailer in North America and is...
See all things: Sears Department Stores & Anchors
Tires, Tune Ups, Batteries, and all kinds of mechanical repair.
See all things: Sears Auto Center Department Stores & Anchors Services
Since we opened our first store in Kansas City 50 years ago, Sears Optical Centers have been improving family eye care by helping families see better and look great. Everything you love about Sears is what you'll find at...
See all things: Sears Optical Services Sunglasses, Optical & Eyewear
Discover Sephora: from unparalleled beauty advice to professional makeovers, tap into the latest products, skincare, and expertise. Be among the first to shop exclusive brands like Marc Jacobs Beauty, Formula X, Bite...
See all things: Sephora inside JCPenney Health, Bath & Beauty
shi by Journeys is your destination for stylish, sophisticated shoes & apparel. Shop today for heels, wedges, flats, sandals, jewelry & handbags at prices you'll love!
See all things: Shi by Journeys Shoes & Footwear Accessories
SHOE DEPT. ENCORE carries popular-price brands as well as Eastland, Timberland, Tommy Hilfiger, Hush Puppies, Life Stride, Rocky Boots, K Swiss, Reebok, Nike, Keds, New Balance and Hi-Tec. We have products from Ladies...
See all things: Shoe Dept ENCORE Shoes & Footwear
Located on the Upper Level near Pottery Barn
See all things: Silver Mountain Jewelry & Watches
We offer the GIFTCARD WITH NOTHING TO LOSE. The American Express/Simon Giftcard now has NO fees after purchase and funds do not expire. Purchase yours today at The Mall at Tuttle Crossing Guest Services. Use only...
See all things: Simon Guest Services Services Variety
Vera BradleyCheck out our full collections of Vera Bradley handbags, accessories, luggage, and stationery. Pandora Jewelry Create memories by wearing or giving the Pandora bracelet and beads.Crabtree & Evelyn...
See all things: Simply Rr's Accessories Arts & Crafts Women's Specialty Home Decor
www.shoplocalsv.com www.shoplocalohio.blogspot.com www.facebook.com/simplyvagueOhio-made clothing, jewelry, accessories, art, and more.
See all things: Simply Vague Specialty & Gourmet Foods Accessories Specialty Shops Arts & Crafts Cards, Books, Gifts & Stationery Home Decor
The best sleep of your life begins with finding your SLEEP NUMBER® setting. Somewhere between zero and 100 is your ideal comfort, whether it's extra firm or featherbed soft. Sleep Number is the only mattress that can meet...
See all things: Sleep Number by Select Comfort Home Furnishings
Smart fix is considered one of the leading companies in the fast pace repair industry. We have 8 locations all over Southern California. Our company was established in 2009 and since then we have fixed 1000s of...
See all things: Smartfix Electronics & Technology
A wide selection of the latest in contemporary hair extensions and distinctive hair accessories.
See all things: SoHo Hair Fashions Accessories
Since being established in 2000, SolarX Eyewear has become one of the world's leading designers, importers and distributors of sunglasses.
See all things: SolarEx Sunglasses Accessories
Spencer Gifts, Inc. is the world's premiere retail specialty gift chain specializing in unique, irreverent, trendy and fad based merchandise. Our product mix makes us more than a specialty retail store; we are an Oasis...
See all things: Spencer Gifts Specialty Shops
Whatever your game, you'll find apparel, specialty memorabilia, gifts and more!
See all things: Sports Possessions Sporting Goods & Athletic Wear Specialty Shops Miscellaneous
Starbucks purchases and roasts high-quality whole bean coffees and sells them along with fresh, rich-brewed, Italian style espresso beverages, a variety of pastries and confections, and coffee-related accessories and...
See all things: Starbucks Coffee Specialty & Gourmet Foods
Stir Fry 88 delivers high quality, authentic Asian products with excellent value. Our menu offers a wide variety of specially prepared dishes featuring traditional wok cooking, the finest ingredients and special sauces. .
See all things: Stir Fry 88 Restaurants (order at the counter)
Backed by more than 90 years of research, Stride Rite shoes are made especially for kids and wear-tested by kids. Scientifically Tested, Everyday Proven. No other company takes this S.T.E.P. Our RITE STEPs system makes...
See all things: Stride Rite Shoes Shoes & Footwear Children's & Infant Fashions
The SUBWAY restaurant chain is the undisputed leader in the submarine sandwich category serving fresh, great tasting, made-for-you sandwiches and salads, many of which have 6 grams of fat or less. Offering a healthful...
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At Sunglass Hut, our mission is to be the premier shopping and inspiration destination for the top brands, latest trends and exclusive styles of high quality fashion and performance sunglasses.
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A melanocyte is a normal cell found in the skin that produces melanin. Melanin is a black or dark brown pigment that is seen in the skin, hair, and parts of the eye. Melanin is transferred from the melanocytes into nearby skin and hair cells. The concentrated areas of color seen on the skin are known as moles or nevi.
Melanoma is a type of cancer that forms from melanocytes. Melanoma is the most serious form of skin cancer and is now the fifth most common cancer in the United States. Even though melanoma accounts for about 5% of all skin cancers, it is responsible for the majority of deaths from skin cancer. Other common types of skin cancer include basal cell carcinoma and squamous cell carcinoma.
In 2013, the American Cancer Society estimates 76,690 new cases of melanoma diagnosed in the United States. The number of new cases of melanoma has steadily increased for the last 30 years. Fortunately, overall death rates have remained relatively stable, reflecting increased survival due to early detection.
Melanoma can occur any place that melanocytes reside. The majority of melanocytes reside in the skin; therefore, the majority of melanomas are found on the surface of the skin, which includes nail beds, soles of the feet, and scalp. However, melanoma can also occur in the eye ("uveal melanoma") or on internal mucosal surfaces, which include the mucous membranes lining the sinuses, the anal canal, rectum, and vagina.
The single most important risk factor for melanoma is exposure to ultraviolet radiation from the sun. Other risk factors for cutaneous melanoma include fair skin or complexion, a history of peeling sunburns, prolonged exposure to ultraviolet light (both sun and artificial UV light), multiple moles, older age, a personal or family history of non-melanoma skin cancer, and a personal or family history of melanoma. As we age, our years of sun exposure increase, and therefore the risk of melanoma increases.
Researchers have found that the risk of melanoma is 2.24 times higher in people with a first-degree relative with the diagnosis; therefore it is important to be aware of your family history. If you have been diagnosed with melanoma, it is important to share this information with your relatives so that they can undergo appropriate screening. While most melanomas do not arise from moles, certain types of moles, called dysplastic nevi, are associated with an increased risk for melanoma. Dysplastic nevi are moles that are typically large (>5mm in diameter), have uneven pigmentation, and irregular borders. A single dysplastic nevi is associated with a 2-fold increased risk, while 10 or more nevi indicate a 12- fold increased risk of developing melanoma.
People with fair skin and light eyes, or those who have a tendency to freckle or burn easily are all at higher risk. Melanoma rates are 20 times higher in Caucasians than in Blacks. The melanin in dark-skinned individuals has been found to have a natural sun protection factor (SPF) and can filter twice as much ultraviolet light as that of a light-skinned individual. This protection, however, is not complete, and melanoma can develop in dark-skinned people. Melanoma is more commonly found on soles, palms, or nail beds in dark-skinned people.
A history of 3 or more sunburns, particularly blistering sunburns, before age 20, greatly increases risk. A history of severe sunburns in childhood and adolescence may actually double the risk of melanoma in adulthood. For many years, the tanning industry has promoted tanning salons as a safe alternative to natural sun because these devices prevent sunburn; however, artificial UV light has definitively been linked with an increased risk of melanoma as well as other types of skin cancer. In fact, women under 35 who have ever used a tanning bed are 50% more likely to develop melanoma than women who never used a tanning bed. The bottom line is that tanned skin, whether from a tanning bed or sunlight, is not healthy and actually indicates that the skin has been damaged.
The best way to prevent melanoma is to protect the skin from exposure to ultraviolet light, which includes natural UV light from the sun and artificial UV light from tanning devices.
Some ways to protect your skin from UV light include:
You should examine your own skin regularly, approximately once a month. Be aware of the shapes and coloring of any moles you have. Melanoma may develop from an existing mole, causing its appearance to change. Examine your skin routinely in a mirror, including your back, bottom of your feet, nail beds, and scalp. Look for changes in existing moles, or the development of new ones.
Concerning moles are ones that have the "ABCDE" characteristics. You should bring any mole with these features to the attention of your health care provider.
These rules are not set in stone, which is why you should be aware of your own moles, and report any changes in moles to a physician
The best screening test is a skin examination. Your physician should examine your skin during routine physicals, but you should also examine your skin routinely at home. Because you see your skin everyday, you are most likely to notice any changes early on. The prognosis for melanoma is best when lesions are found early, making skin examination very important.
Melanoma often presents as an irregular mole on the surface of the skin, with the "ABCDE" characteristics described above. This can be a preexisting mole that has changed or a newly developed mole. However, many melanomas do not possess these features, so any changes in your skin should be brought to the attention of your health care provider. Additionally, more advanced lesions may have inflammation, oozing, crusting, itching, ulceration or bleeding. Sometimes, specialized photography can be utilized to help monitor a person's skin; these pictures can make it easier for both the patient and the health care provider to detect any changes in moles. This can also cut down on unnecessary biopsies by showing stability of moles over time.
Unfortunately, some patients with melanoma do not present with an abnormal skin lesion and the first signs and symptoms of the disease result from metastatic spread to other organs.
When melanoma is suspected, an excisional or an incisional biopsy should be performed. These biopsy techniques are both "full-thickness", removing the lesion and all the layers beneath it, allowing the depth of the lesion to be accurately determined. The depth of the lesion determines prognosis and treatment, so it is important for this to be accurate. An excisional biopsy removes the entire lesion, while an incisional biopsy removes only a portion of the lesion—an incisional biopsy is usually used for very large lesions to confirm the diagnosis before treatment. The alternative is a shave biopsy, which does NOT allow for accurate assessment of lesion depth.
The four most common subtypes of melanoma are:
While acral lentiginous melanoma is the least common in Caucasians, it is the most common form of melanoma in dark-skinned populations and is usually found on the palms, soles or under the nail. In general, the subtype of melanoma is not a major factor in determining prognosis.
Melanoma can also arise in the mucosal surfaces, known as mucosal melanoma (i.e. sinuses, gastrointestinal tract, urinary tract and vagina) and in the eye, known as ocular or choroidal melanoma. The initial surgery and management of these types of melanoma are different than melanomas that occur on the skin.
After the initial biopsy is performed, a pathology report is issued by the dermatopathologist. This pathology report further describes numerous aspects of the melanoma, which help determine the overall prognosis, many of which are highly technical and outside the scope of this article. The most important aspects of the pathology report are the depth of the melanoma, whether or not ulceration is present, and the mitotic count in thin melanomas.
The depth of the melanoma is often referred to as the Breslow depth or thickness. It describes the vertical depth of the melanoma in millimeters. Other measurements that may be included on the pathology report are the Clark's level, which describes the layer of skin involved with melanoma, and the diameter of the melanoma; neither of these measurements impact the staging of melanoma. Be careful not to confuse Clark's level with the stage of melanoma.
After evaluating the features of the primary melanoma, which are reported on the pathology report, a second surgical procedure, called a wide local excision, is typically performed. At the same time, evaluation of the local lymph nodes, through a sentinel lymph node biopsy may also be performed.
Surgery is the mainstay of curative treatment for melanoma. After a melanoma is diagnosed by a biopsy, the next step is to have a "wide local excision". This surgical procedure removes an area of normal tissue around where the lesion was located. The amount of tissue removed is based on the depth of the melanoma. "Margins" refer to the tissue around a tumor, in this case melanoma. "Negative margins" mean a small amount of normal tissue around the entire tumor was also removed—this ensures the entire melanoma is removed. "Positive margins," on the other hand, indicate that melanoma extends all the way to the edge of the tissue removed, and that it is possible some melanoma may not have been removed. The planned surgical margin depends primarily on the Breslow depth and generally range from 0.5 to 2cm.
If the melanoma is deeper than 1mm or has other features associated with a greater risk of recurrence, a sentinel lymph node biopsy may be performed. In a sentinel lymph node biopsy, a blue dye with a radioactive tracer is injected into the site of the original tumor. The dye spreads to the "sentinel node(s)" (the first few nodes to which the cancer would spread). These blue / radioactive lymph nodes are removed, examined under a microscope and tested for cancer. If any of these lymph nodes are positive, the remaining lymph nodes in the region are removed, a procedure known as a lymph node dissection or lymphadenectomy. If the sentinel nodes do not contain melanoma, a lymph node dissection can be avoided and potential complications eliminated.
Staging for melanoma is defined by the American Joint Committee on Cancer (AJCC, 2009) using Breslow Depth as follows:
*Note that you may not always identify the primary skin lesion in Stage III-IV disease. This is known as "melanoma with unknown primary."
Melanoma can also spread into the region between the original site and the lymph nodes. These lesions are called "in-transit metastases." These are often treated with the treatment modalities used in Stage III or IV disease. Patients with stages III-IV require further evaluation for metastases often including CT scans, PET scans, and/or MRI.
In Stages IIB, IIC and III melanoma, the cancer has been removed by the surgery, and there is no evidence of disease on physical examination, laboratory tests, or radiology tests. Unfortunately, there are often tumor cells circulating in the body that we cannot see on scans. For this reason, patients may be offered further treatment with medications or radiation, which is called adjuvant treatment.
Surgery is the mainstay of curative treatment for melanoma. As mentioned above, the initial diagnosis is made following a biopsy. Additional surgeries may include a re-excision of the primary skin lesion, a wide local excision, a sentinel lymph node biopsy, and a completion lymph node dissection.
If melanoma returns, surgery can often be used to remove the sites of recurrent disease. Additionally, surgery can be utilized in advanced melanoma to manage symptoms associated with a particular tumor.
Chemotherapy is the use of chemicals or medications that travel to all tissues throughout the body to kill any cancerous cells. These therapies have an effect on melanoma that can be seen on imaging studies as well as melanoma cells that cannot be seen. Chemotherapy agents commonly used in melanoma treatment include: Dacarbazine, cisplatin, carboplatin, temozolomide, abraxane and paclitaxel.
In melanoma, some of the medications used to treat this condition are considered immunotherapy agents, meaning that they work by stimulating the patient's own immune system into attacking cancer cells. Some immunotherapy agents used in melanoma are interferon, interleukin-2, and ipilimumab.
Interferon alfa has been the mainstay of adjuvant therapy for melanoma (adjuvant therapy is any treatment given along with the primary treatment, in this case surgery, when there is no evidence of melanoma). Interferon alfa is the best studied and has shown to improve disease-free survival in certain patients with Stage II/III melanoma. However, the benefit on overall survival is still unclear and the therapy has side effects that impact quality of life. The two forms of interferon alpha that are utilized in melanoma are Intron-A® and Sylatron®. Sylatron® is a specially formulated form of interferon that is administered once a week.
Interleukin-2 is used to treat advanced or metastatic melanoma. It is administered intravenously in specialized treatment centers. It must be administered in a hospital because of the side effects associated with this therapy.
Ipilimumab, was approved in 2011 for use in the treatment of metastatic or unresectable melanoma. Ipilimumab is a monoclonal antibody therapy, which works to stimulate the immune system to destroy cancer cells. It takes the "brakes" off the immune system, by increasing the number of T-cells. Ipilimumab led to improved survival in people with advanced melanoma. The side effects of this therapy result from this increase in the activity of T-cells in other organs of the body, most commonly the skin, the digestive tract, the liver, or the endocrine system. Good communication with your health care providers is essential when you are receiving this therapy.
As more is learned about the development of melanoma, molecular targets within melanoma cells are being discovered and new therapies are developed to attack these targets. BRAF is a protein kinase that plays a role in regulating the pathways responsible for cell replication and survival. In approximately 50% of melanomas, this protein is altered or mutated. There are therapies that target mutated BRAF and can be utilized in patients with melanoma containing a specific BRAF mutation. These medications only work in melanoma that has a mutated form of BRAF and testing is performed prior to starting therapy to assure that the therapy is appropriate for the patient. To test for mutated BRAF, a sample of the tumor is sent to a special laboratory that performs the test.
There are two medications available that target mutated BRAF. Vemurafenib was approved by the FDA in 2011 and Dabrafenib in 2013. Both of these medications are taken by mouth (orally). Although they target the same protein, the dosing and side effects of these two agents are slightly different. They are both associated with an increased development of squamous cell carcinomas of the skin, EKG changes, and UV sensitivity, among others. Dabrafenib has also been associated with fevers and serious febrile reactions.
MEK is another protein along the same pathway as BRAF. Trametinib is a MEK inhibitor that was approved by the FDA in 2013. It has been shown to be effective in patients with BRAF-mutated melanoma who have not been previously treated with a BRAF inhibitor. It is an oral medication with specific requirements for storage and monitoring. It has been associated with a variety of side effects including cardiac effects, retinal effects, pulmonary effects, and skin toxicities.
Another option for patients with multiple melanoma tumors confined to one limb is isolated limb perfusion (ILP) or isolated limb infusion (ILI). These procedures involve temporarily interrupting circulation to the affected limb and administering high doses of chemotherapy (such as melphalan) to the limb, along with heat. These procedures must be performed under anesthesia in the operating room; they are associated with local side effects, but have limited toxicity to the rest of the body. This is usually reserved for melanoma that is isolated to a single limb and is not amenable to surgical resection. Response rates ILP/ILI are variable. Some studies have shown a benefit to overall survival in those patients who respond completely (no residual disease) to ILP.
Radiation therapy uses high energy x-rays to kill cancer cells and is a localized treatment, meaning it only affects the tissues directly treated with radiation. Radiation is not routinely used to treat all cases of melanoma. However, in Stage III melanoma, radiation therapy has been shown to be beneficial when used to treat areas at high risk for recurrence, such as lymph node basins. In this setting, radiation therapy can help to prevent a recurrence in the area treated with radiation. Additionally, in Stage IV melanoma, radiation may be used to treat distant metastases in the brain and bone, to reduce symptoms related to the disease or to prevent a decline in function.
Stereotactic radiosurgery (SRS, Gammaknife, Cyberknife) is a highly precise form of radiation therapy that is used to treat metastases. Stereotactic radiotherapy delivers radiation from many different angles to focus the radiation at one small point, like a magnifying glass. It is generally given in 1-5 treatments, unlike traditional radiation, which is given daily, over a period of weeks.
Clinical trials play a pivotal role in the treatment of melanoma. There are many new therapies being evaluated in clinical trials for use in various stages of melanoma. Clinical trials provide patients access to these new and exciting therapies. In addition to testing new treatment options for patients, clinical trials also can provide access to the use of new combinations of existing therapies, not previously used together. Clinical trials are also using therapies that have been shown to extend survival in Stage IV melanoma and in Stage III melanoma to determine if earlier use of these agents may reduce the risk for recurrence. Current clinical trials may include: the identification of new targets for melanoma treatment, targeted therapies that work on newly discovered targets in melanoma, vaccines (which can be made from the patient's own tumor cells or parts of melanoma cells), new combinations of chemotherapy and immunotherapy, and new surgical techniques.
New medications and techniques are continually being tested to find more effective therapies for this disease. It is crucial that patients with a diagnosis of stage III or IV melanoma be treated by a melanoma specialist who is well-versed in current treatments, available clinical trials, and works with an interdisciplinary team (radiation, surgery, supportive care services) to manage patients with all available treatments. Patients with Stage IV disease will require regular clinical, laboratory and imaging evaluations to monitor their disease and response to treatment.
You can learn more about ongoing clinical trials and find those that may be right for you using the OncoLink Clinical Trials Matching Service or at clinicaltrials.gov.
After a diagnosis of melanoma, patients remain at risk for the development of a new melanoma or non-melanoma skin cancer and for a recurrence of the previously diagnosed melanoma. Having one melanoma in a patient's lifetime places him/her at higher risk for developing a second melanoma and follow up with a dermatologist is a mainstay of on-going treatment, with a complete skin exam at least once a year. All patients require ongoing follow up with their dermatologist and depending on the stage of the original melanoma, may require ongoing monitoring by their surgeons and medical oncologists.
For most patients diagnosed with Stage I and II melanoma, follow up will consist of clinical full body skin examinations with a dermatologist every 3-12 months for life, the frequency of which depends on the time elapsed since diagnosis. In addition to clinical total body skin exams, patients should perform self skin examinations about once a month, checking for any new or changing skin lesions, looking for the ABCDEs of melanoma risk, and looking for any new lumps or bumps in the area of the prior melanoma. Individuals diagnosed with a melanoma should practice safe sun habits to minimize their risk for developing a second melanoma or non-melanoma skin cancer (Sun Safety Tips) Routine blood and radiology tests are not recommended for stages I-II, but should be performed to investigate any concerning symptoms.
For patients with Stage III melanoma, a clinical full body skin examination should be performed every 3-12 months for life, the frequency of which depends on the time elapsed since diagnosis. In addition to examination of the skin, the lymph nodes should also be examined. Members of the health care team in Stage III patients may consist of a dermatologist, a surgical oncologist, and a medical oncologist. Additionally, some patients with Stage III melanoma may have regular blood work and imaging studies for approximately 5 years following the diagnosis. Blood work may consist of a complete blood count, liver functions tests, metabolic markers, and an LDH (lactate dehydrogenase), as well as other laboratory tests depending on the previous treatment. Radiology testing may include ultrasound, CT scans, or MRI.
For patients with Stage IV melanoma, a clinical full body skin examination should be performed every 3-12 months for life, the frequency of which depends on the time elapsed since diagnosis. In addition to examination of the skin, the lymph nodes and other organ systems should also be examined. Members of the health care team in Stage IV patients may consist of a dermatologist, a surgical oncologist, and a medical oncologist. Additionally, patients with Stage IV melanoma will likely have regular blood work and imaging studies for at least 5 years following the diagnosis. Blood work may consist of a complete blood count, liver functions tests, metabolic markers, and an LDH (lactate dehydrogenase), as well as other laboratory tests depending on the previous treatment. Radiology testing may include ultrasound, CT scans, or MRI.
Melanoma survivors should report any of the following to your healthcare providers:
Cancer survivorship is a relatively new focus of oncology care. With some 13 million cancer survivors in the US alone, there is a need to help patients transition from active treatment to survivorship. What happens next, how do you get back to normal, what should you know and do to live healthy going forward? A survivorship care plan can be a first step in educating yourself about navigating life after cancer and helping you communicate knowledgeably with your healthcare providers.
Create a care plan today on OncoLink
This article is meant to give you a better understanding of the basics of melanoma. Use this knowledge when meeting with your physicians, making treatment decisions, and continuing your search for information.

subset: commoncrawl


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Does this affect any efforts to build an OS on the latest Linux and GTK 3 and just *not support X11*? I know there are experimental OSes out there, like ReactOS and the Amiga OS clone, but if there's something radical that's actually going to work itself back into Ubuntu, I might be interested.
Do any GTK3/Wayland/Linux-KMS distributions currently exist?


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Kosher Bread
Whole Wheat Honey Bread |
KosherEye.comAdapted from Red Star Yeast Out of all the recipes in our collection, Whole Wheat Honey Bread, best known as Honey of a Whole Wheat Bread, is our most requested recipe. The ingredient amounts are available for three sizes: small, medium, or large. Ingredients:
Directions: Bread Machine Method: Mixer Methods: Hand-Held Mixer Method: Stand Mixer Method: Food Processor Method Rising, Shaping, and Baking: Notes: For a non-dairy bread, substitute non-dairy milk product such as soy milk, rice milk, etc. **You can substitute Instant (fast-rising) yeast in place of Active Dry yeast. When using Instant yeast, expect your dough to rise faster. Always let your dough rise until ripe. Traditional methods: use equal amounts; Bread Machine: use ½ tsp Instant yeast OR ¾ tsp Active Dry yeast per cup of flour in your recipe. Visit our Lessons in Yeast & Baking for more information on baking. Recipes: Bread, Whole Wheat, Honey, Yeast, Dairy or Parve, Kosher |


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EnviroTech :: R&D Total and Amyris Expand Renewable Fuels Partnership9:12 AM MST | December 8, 2011 | Natasha Alperowicz Total and Amyris (Emeryville, CA) have signed agreements to expand their current R&D partnership and form a joint venture to develop, produce and commercialize a range of renewable fuels and products. The companies have agreed to expand their collaboration to accelerate the deployment of Biofene and develop renewable diesel based on the molecule produced from plant sugars. The R&D program, launched in 2010 and managed by researchers from both companies, aims to bring the next generation renewable fuels to market at commercial scale. Total is contributing... This information is only available to Chemical Week subscribers. Forgot your user ID or password?
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Campaign for Kalydeco
Kalydeco is a transformational treatment that has been appraised and confirmed as having a significant clinical benefit for people with cystic fibrosis over the age of six with the G551D gene mutation.
It is vital that a fair and affordable arrangement is reached soon between the NHS and Vertex, the drug's manufacturers, to ensure all who would benefit from the drug receive it as soon as possible at a reasonable cost to the NHS.
We welcome the work of NHS commissioners and advisors in England to accelerate the system of approval, and their recognition of the drug's clinical benefit. We also welcome the work continuing in Scotland, Wales and Northern Ireland to appraise the treatment.
We therefore call on both Vertex and the NHS to recognise, when they meet this month, that they have an unprecedented opportunity to make available a treatment which has the potential truly to change the lives and outlooks of patients with cystic fibrosis in England who carry the G551D mutation.
We call upon Vertex to recognise the financial pressures on the NHS and to demonstrate an ability to deliver innovative and cutting-edge treatments at a price which is affordable. We call upon the NHS to demonstrate that it has the will and capability to make such treatments available to patients on an equal and speedy basis.
Bill Whiteford
Please add my name to this petition to help the grandson of our friends.
Leon Bennett
It's unclear to me why Australia is so conservative in adopting new drug treatments,
Anthony Drew
My grandson has this disease it is not very pleasant to see him so sick.His name is Flynn Morrison the little boy in your flyer
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Square Toe Work Boots
When you are looking for a stylish pair of work boots, this selection of square toe boots will certainly spice up your style. With many different boots to choose from, including steel and composite toe styles, you will be sure to find what you are looking for in a work boot. Rocky, Ariat, and many more brands are offered in the square toe boot style.
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Our evening walk. New Mexico skies are spectacular.
There's been a hint of fall in the air. The deep night sky glitters with stars. Mornings are cool, bordering on chilly. I stand outside the portal's edge, in the sand, sipping a mug of yerba mate, and scan the cottonwoods along the bosque below, looking for the tell-tale tinge of gold.
Soon they will be yellow, a golden trail north that snakes along the Chama River. It will be time for stacking pinon to burn in the kivas. I relish the warmth of the cozy fires to come, the evenings spent wrapped in thick sweaters reading, sipping cognac.
And for the first time in years I am not dreading winter.
And for the first time in years I am not dreading winter.
Baked chicken with peppers is gluten-free. |
Alex's Favorite Baked Chicken Mediterranean
This is my son Alex's favorite baked chicken recipe. It's a family-style recipe that constantly changes yet retains its essential character- that of pure comfort food laced with the best of Mediterranean flavors. It's lovely served over fragrant brown rice or herbed quinoa. Or serve it with sea salt-roasted potato wedges. It's an easy weeknight dish for the chilly days of autumn.
4 split organic free-range chicken breasts [skinless are fine]
Sea salt and gluten-free Lemon Pepper seasoning, to taste
1 14-oz can Muir Glen fire-roasted tomatoes with juice
3/4 cup of your Muir Glen pasta sauce
1/4 cup balsamic vinegar
1/2 cup red wine
6 cloves garlic, chopped
2 cups of thin pepper strips- mixed green, yellow and orange peppers
2 large portobella mushrooms, sliced
10 to 12 grape or cherry tomatoes, halved
1/2 cup chopped black olives
2 heaping tablespoons capers
1/2 cup golden raisins
1 tablespoon dried basil
1 teaspoon dried oregano or marjoram
Preheat the oven to 350 degrees F.
Lightly oil a 10x13-inch baking pan with olive oil.
Wash the chicken in cold water and pat dry; season with lemon pepper; place in the baking dish.
In a mixing bowl, combine the remaining ingredients and pour over the chicken breasts.
Loosely cover with foil and bake until the chicken is no longer pink inside, anywhere from 30 to 45 minutes depending upon the size of the chicken breasts, etc.
Serve with brown rice, quinoa or mashed potatoes. Offer crumbled feta or goat cheese as a garnish.
Serves 4.
Recipe Source: glutenfreegoddess.blogspot.com
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Ecological Laboratories Microbe-Lift Spray Flavor Enhancer (8 oz.)
Ecological Laboratories Microbe-Lift Spray Flavor Enhancer (8 oz.)
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Ecological Laboratories Microbe-Lift Spray Flavor Enhancer (8 oz.)
Liquid krill flavor enhancer for pond fish food.
Spray onto any food to enhance flavor!
Improves taste of oral medications & convalescent diets
Enhances flavor of feeds with high protein content
Compliments the range of essential fatty acids, vitamins & minerals in the diet
Microbe-Lift/Enhance liquid krill flavor enhancer is a highly pigmented protein rich liquid made from 100% Euphausia superba (krill)—a major natural food source of many marine creatures and part of their natural diet. Microbe-Lift/Enhance is nutritionally complete containing proteins, lipids, pigments, vitamins, enzymes and many other important constituents. During a process called hydrolysis, the protein is semi-digested and the maximum digestive potential of the krill is realized.
Microbe-Lift/Enhance is a powerful flavorant with superior flavor characteristics because of the complex aromatic compounds released during bio-processing. The pre-digestion of the protein produces a maximum attractment response, with its characteristics especially useful in helping stressed fish resume feeding and helping in delivery of oral medications.
Protein & Amino Acids
The protein quality in Microbe-Lift/Enhance is excellent, making it an ideal protein with a full complement of all essential amino acids.
Fatty Acids & Natural Antioxidents
Mircobe-Lift/Enhance is a rich source of a wide variety of fatty acids and natural anti-oxidants which inhibit the oxidation of fatty acids.
Natural Pigments
The krill in Microbe-Lift/Enhance contain high concentrations of carotenoid pigments—Astaxanthin in particular, which enhances coloration to the skin of ornamental fish.
Microbe-Lift/Enhance is ideally suited either for mixing into food or coating it. It is the perfect flavor enhancer (attractement). Store in a cool, protected environment away from direct sunlight.
Manufacturer Info
Ecological Laboratories Aquarium Supplies
Ecological Laboratories is an international biotechnology company specializing in the development and production of microbial products for the natural treatment of environmental issues associated with the various uses of water and recycling of organic matter. In 1976, Ecological Laboratories began producing Microbe-Lift, a one-of-a kind formula for use in a broad spectrum of applications in the agricultural, industrial and wastewater treatment fields. It became clear that with a little tweaking, what these bacterial formulations do on a large scale for commercial use can also be valuable on smaller scale applications such as ornamental ponds, aquariums and water gardens. In 1998, Ecological Laboratories began packaging Microbe-Lift for end-users. Ecological Laboratories uses outside testing labs for independent analysis of their products. Product testing and monitoring is done regularly as an important part of their quality control process.
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A well-balanced cleanser is essential to a healthy and effective skincare regimen, but often cleansers sacrifice powerful ingredients in an attempt to avoid skin irritation. While skin should not be irritated after using a cleanser, it should be left fully cleansed and hydrated. If your skin has special needs, it is also possible to incorporate treatment into your cleansing routine. With AFA Amino Acid Skin Care Cleansers, your skin will be left smooth and radiant as amino acids work to gently exfoliate skin. Your complexion will be rejuvenated and protected against future damage, as AFA Amino Acid Skin Care Cleansers include potent antioxidants.
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Cleansers should be gentle enough to use regularly without harming your skin, but they also need to be effective at cleansing your skin of dead cells and debris that accumulate throughout the day. AFA Amino Acid Skin Care Cleansers cleanse skin while gently exfoliating and protecting skin with the help of amino acids. With regular use, AFA Amino Acid Skin Care Cleansers will improve the texture and clarity of your skin.
Many exfoliators can be harsh and can strip the skin of its natural moisture and oils. AFA Skin Care Cream Cleanser serves your skin well by removing impurities, excess oil, makeup, and other residue without stripping your skin. This soap-free cleanser relies on amino acids to gently exfoliate your skin, leaving it smooth and ultimately clean. The formula also works to protect your skin from potentially damaging environmental factors. After using, your skin will feel soft and smooth, and over time you will notice that your skin tone and texture appear healthier and more even. AFA Skin Care Cream Cleanser is ideal for normal to dry skin types.
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Phone: 503-823-7300
Email: firstname.lastname@example.com
1900 SW 4th Ave, Portland, OR 97201
Phone: 503-823-7300
Email: email@example.com
1900 SW 4th Ave, Portland, OR 97201
The Adjustment Committee, authorized under Portland City Code 33.710.070, reviews adjustment requests to the development standards of Title 33 [Planning and Zoning Regulations].
The committee assists the BDS in reviewing innovate sustainable building technologies and methods for compliance with the Building Code requirements.
The Building Code Board of Appeals is authorized under Portland City Code 24.10.080 and the State of Oregon Structural Specialty Code.
The Design Commission, authorized under Portland City Code 33.710.050, provides leadership and expertise on urban design and architecture and on maintaining and enhancing Portland's historical and architectural heritage.
A citizen advisory body representing those with interest in policies, budgets and regulations affecting development review processes. (Vacancy in 1 member category: Large Developers)
The Electrical Code Board of Appeals hears appeals where an applicant is aggrieved by the findings of the Director.
In June 2010, the City Council directed the Office of Management and Finance to convene a committee of economic and commercial experts to review BDS's financial projections and 5-Year Financial Plan.
The Floating Structures Code Board of Appeals will consisting of six members and six alternates who are knowledgeable about construction as regulated by the base building codes and the construction and maintenance of floating structures and moorage facilities.
The Historic Landmarks Commission provides leadership and expertise on maintaining and enhancing Portland's historic and architectural heritage.
Information Technology Advancement Project (ITAP) Customer Advisory Committee is a citizen advisory committee, comprised of approximately 12 members who represent a variety of interests.
The Mechanical Board of Appeals determines the suitability of alternate materials and types of construction and provides for reasonable interpretations of the provisions of the Mechanical Code.
The Plumbing Code Board of Appeal consists of three members appointed by the Mayor.
The River Community Advisory Committee is a citizen advisory body, comprised of six members who represent a variety of floating structures interests.
The Structural Engineering Advisory Committee is appointed by the Mayor and consists of three members and three alternates licensed in Oregon to practice structural engineering.


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A dataset of DMEPOS Competitive Bid Suppliers in McAllen-Edinburg-Mission, TX.
created Apr 29, 2013
updated Apr 28, 2015
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Harmonic Balancer Puller - 1AEHB00094
1AEHB00094This part replaces:
- New
Most Harmonic balancers are pressed on to the end of the engine crankshaft.
This is the correct removal tool for pressed on harmonic balancers.
Severe engine damage can be the result of "alternative" methods of removal.
This Puller does have a long Press Bolt. If you are removing the Harmonic Balancer without removing the engine it may not clear in some applications. A different length hardened bolt of the same diameter and thread count can be substituted if necessary.
Lifetime Warranty
This item is backed by a Limited Lifetime Warranty. In the event this item should fail due to manufacturing defects during intended use, we will exchange the part free of charge (excludes shipping charges) for the original purchaser. Please keep your invoice for proof of this warranty.
Part #: 1AEHB00094
Ships Same Day for orders placed by 5 P.M. ET
Free GROUND SHIPPING
Check Shipping RatesCustomer Feedback
"Thanks for the fast reliable service. Great price, and the headlights were as good as oem or better!!! Keep up the good work..."- Dwuan M.
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From Olay & MyBlogSpark:
Let´s face it; we all want our skin to look as youthful as possible at any age. With so many moisturizing and anti-aging products available, knowing which one will really keep your skin looking and feeling its best may be overwhelming.
Luckily, the solution is easy with Olay Total Effects. New Olay Total Effects Body Wash - Deep Penetrating Moisture, one of the newest additions to the line, can help your skin look visibly younger with an appearance that´s more resilient to aging.
Olay´s most advanced body wash, Total Effects goes beyond cleansing to deeply moisturize and fight 7 signs of aging all over your body by helping to improve elasticity, relieve dryness, deeply moisturize, brighten dull skin, even skin tone, smooth rough skin, and minimize the appearance of dry lines.
With jojoba butter and VitaNiacin, Olay Total Effects Body Wash - Deep Penetrating Moisture can help you get soft, smooth skin in one shower, improved elasticity in one week, and young-looking, radiant skin in one month. Proven effective in fighting multiple signs of aging, the exclusive VitaNiacin formula helps rejuvenate and beautify your skin while improving the condition of the skin´s moisture barrier. Also available is the Olay Total Effects Body Wash - Exfoliating and Replenish, which has micro-derm beads and VitaNiacin to help keep you looking and feeling young.
My Review
First of all, the bottle design is very appealing. I love the look of it and that it fits so well in my hands.
The fragrance is very appealing, too. It's a light scent that stays on my skin long after I've gotten out of the shower, which I like. I like smelling clean!
The texture is smooth and thick! I really liked how it lathered up on my puff. The nice part, you don't have to use a lot for it to go a long way! Honestly, I wish I'd have had this product in January/March because my skin was so dry in the Minnesota winter. This is the first year my legs have been itchy. I could tell an immediate difference after my first shower. My skin was moisturized and no more itching!
Win A $10 Gift Card To Wal Mart
Required: Tell me one way you keep your skin moisturized in the winter.
Giveaway open to all US residents 18 yrs and older. You must leave contact information in case you win either your email or have it available in your profile. No email/contact = No entry. Giveaway ends April 26th, 10pm CDT.
Extra Entries:
♦Follow my new review site Marvelous Mom Reviews (2 extra entries, comment 2x)
♦Become a subscriber of Marvelous Mom Reviews (3 extra entries, comment 3x)
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I'd like to thank Kelly for the product, prize pack, information, and giveaway that have all been provided for by Olay through MyBlogSpark.


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Historic Site Tour &
Progressive Dinner
Step back in time and dine in the elegance of Victorian era Dubuque while on this historic sites tour and dinner package. Learn about the architecture, families and events that made 19th century Dubuque such a unique treasure. Enjoy a gourmet meal as a trained guide takes you through some of Dubuque's most beautiful historic sites-it's a culinary and visual feast! Plus, period-themed entertainment will provide an additional element of delight to your tour. Make your reservation today and go back in time to visit Victorian-era Dubuque at its best.
The Historic Sites Tour & Progressive Dinner is available to groups of 20 to 55 people April through October.
Tour Prices (includes tour guide, meals and all applicable taxes):
- Four-Stop Tour & Progressive Dinner = $50 per person
- Three-Stop Tour & Progressive Dinner = $46 per person
For more information or to make reservations, contact Nate Breitsprecker at (563) 557-9545 ext. 214 / (800) 226-3369 ext. 214 or e-mail firstname.lastname@example.com.


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See more: Blocks & Building
Sold Out
Baby's First Blocks
This product is unavailable
Inspire hours of creativity by adding Baby's First Blocks by Haba to the playroom. In six basic colors, the twelve simple cubes are easy for your infant to hold and maneuver as he practices balancing and stacking. He'll begin to discover cause and effect when he notices that a stack of blocks will fall down when nudged. Learning opportunities abound with these multi-purpose blocks. All solid wood is only taken from PEFC-certified sustainable forests in Germany.
- Recommended for babies 6 months and older
- 12 cubes in 6 basic colors
- Each block measures approximately 1.5 x 1.5 x 1.5 inches
- Made of beech wood coated with multiple layers of water-based, natural, solvent-free lacquers
- Lovingly designed in Germany by our friends at Haba
- Made in Germany


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Parliament of Australia
House is not live
House of Representatives
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Current section pages
My Parliament
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Clicking the 'From' and 'To' fields displays a calendar. Alternatively select date by typing into these fields in the format 'dd/mm/yyyy'.
Current Bills
Previous Bills
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Fair Work Amendment (Textile, Clothing and Footwear Industry) Bill 2012
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Bill | Explanatory Memorandum
Food Standards Amendment (Truth in Labelling—Palm Oil) Bill 2011
Financial Management and Accountability Amendment (Value for Money in Government Spending) Bill 2010
Food Importation (Bovine Meat Standards) Bill 2010
Food Standards Amendment (Truth in Labelling—Palm Oil) Bill 2009
Families, Housing, Community Services and Indigenous Affairs and Other Legislation Amendment (Restoration of Racial Discrimination Act) Bill 2009
Food Standards Amendment (Truth in Labelling Laws) Bill 2009
Fair Work Amendment (Paid Parental Leave) Bill 2009
Food Safety (Trans Fats) Bill 2009
Freedom of Information (Removal of Conclusive Certificates and Other Measures) Bill 2008 [2009]
A bill is a proposal for a law or a change to an existing law. A bill becomes law (an Act) when agreed to in identical form by both houses of Parliament and assented to by the Governor-General.
Parliamentary sitting calendar
Go to the full calendar of events
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Book your room at Homewood Suites by Hilton La Quinta
Studio suite king bed
Max Occupancy: 4 guests (up to 3 children, 3 infants)Suite, 1 Bedroom
Max Occupancy: 4 guests (up to 3 children, 3 infants)One KG HEARING ACC SUITE NSMK
Max Occupancy: 4 guests (up to 3 children, 3 infants)Suite, 1 Bedroom
Max Occupancy: 6 guests (up to 5 children, 5 infants)Boardroom suite king
Max Occupancy: 4 guests (up to 3 children, 3 infants)Suite, 2 Bedrooms, 2 Bathrooms
Max Occupancy: 6 guests (up to 5 children, 5 infants)Suite, 2 Bedrooms, 2 Bathrooms
Max Occupancy: 8 guests (up to 7 children, 6 infants)Studio suite king bed smoking
Max Occupancy: 4 guests (up to 3 children, 3 infants)La Quinta, CA hotel with complimentary breakfast
Located in La Quinta (South Entrance Joshua Tree), Homewood Suites by Hilton La Quinta is convenient to Indian Wells Tennis Garden and One-Eleven La Quinta Centre.
This hotel is within close proximity of Old Town La Quinta and Bear Creek Trail.
Make yourself at home in one of the 130 air-conditioned rooms featuring kitchens with full-sized refrigerators/freezers and stovetops. Video-game consoles and premium TV channels are available for your entertainment, while MP3 docking stations help you enjoy your music in the comfort of your room. Conveniences include phones, as well as safes and complimentary newspapers.
Enjoy a range of recreational amenities, including an outdoor pool, a spa tub, and a fitness center. Additional amenities include concierge services, gift shops/newsstands, and shopping on site.
Mingle with other guests at a complimentary reception, held on select days. A complimentary hot/cold buffet breakfast is served daily.
Featured amenities include complimentary high-speed (wired) Internet access, a business center, and express check-in. Event facilities at this hotel consist of conference space and meeting rooms. Free self parking is available onsite.
Information missing or incorrect? Tell us!Hotel Amenities
Hotel Amenities
At Homewood Suites by Hilton La Quinta, you'll enjoy a range of inclusive perks to help you feel right at home. Indulge in a hot full breakfast each morning and evening dinner and drinks (local and state laws apply) Monday through Thursday. Homewood Suites offers a complimentary grocery shopping service - and if you forget something, there's a 24-hour on-site convenience store. Other benefits include newspaper delivery every weekday and complimentary WiFi.
- 24-hour front desk
- ATM/banking
- Barbecue grill(s)
- Business center
- Coffee/tea in lobby
- Free newspapers in lobby
- Free breakfast
- Concierge services
- Conference space
- Dry cleaning/laundry service
- Elevator/lift
- Express check-in
- Express check-out
- Fireplace in lobby
- Fitness facilities
- Gift shops or newsstand
- Free wired high-speed Internet
- Luggage storage
- Shopping on site
- Laundry facilities
- Meeting rooms
- Multilingual staff
- Number of floors - 3
- Total number of rooms - 130
- Free self parking
- Outdoor pool
- Television in lobby
- Free reception
- Spa tub
Available in some public areas: Free wired high-speed Internet
Free self parking
Room Amenities
- Air conditioning
- Blackout drapes/curtains
- Ceiling fan
- Climate control
- Coffee/tea maker
- Free newspaper
- Cookware, dishware, and utensils
- Cribs/infant beds available
- Separate sitting area
- Hair dryer
- Daily housekeeping
- Iron/ironing board
- Kitchen
- Microwave
- In-room safe
- Premium TV channels
- Sofa bed
- Phone
- Television
- Video-game console
- Dishwasher
- Full-sized refrigerator/freezer
- Stovetop
- MP3 docking station
Where to Eat
Guests are welcome to complimentary Suite Start Hot Breakfast 7 days a week and complimentary Welcome Home Reception featuring a light meal and beverages, Monday-Thursday nights.
Nearby Things to Do
Homewood Suites by Hilton La Quinta offers an outdoor pool and fitness equipment.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Bicycle rentals nearby
- Hiking/biking trails nearby
- Mountain biking nearby
- Ecotours nearby
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible bathroom
- Roll-in shower
- Accessible parking
- In-room accessibility
- Accessibility equipment for the deaf
- Braille or raised signage
Hotel Policies
Minimum check-in age is 21
Check-in time starts at 3 PM
Check-out time is noon
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Only service dogs are allowed
No rollaway/extra beds available
We should mention
Only registered guests are allowed in the guestrooms.


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Photographs transport people to an earlier time without the need to master quantum physics or pay the tolls associated with North America's wormhole highways. Capture fleeting moments for future examination with this Groupon.
Choose from Three Options
- $39 for one online certification program in digital photography, Photoshop, Web Animation (Flash), or Web Development (Dreamweaver) ($450 value)
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Each course includes a full trial version of the software for each class. During 14-hour certification programs taught through comprehensive online tutorials, students are taught photography, photo manipulation, or web-based skills with high-resolution module exercises by experienced instructors, who are regularly available for feedback. The online classes equip students with 24/7 access to the lessons and tutorials, allowing students of all backgrounds to complete the classes at their own paces and using their own learning objectives. Students will receive their certification upon course completion. Register here for an online class.
This deal's value is based in a different currency than its Groupon purchase price, so the exact discount and amount saved depend on the exchange rate.
"Good course but slightly advanced level for the novice user."
"This is good for beginners."
"The offers are irresistible. "


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Introducing Cisco Mobile Workspace Solution
This highly secure and smart solution simplifies delivery of mobile work environments on a variety of devices, anywhere.
Information For
Help people work together to solve problems, make decisions, and present ideas faster regardless of distance.
Data Center and Virtualization
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US/CAN | 5am - 5pm Pacific
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What's OnBy seasonSpring 2015 Summer 2015 Autumn 2015 By venueBelfast Grand Opera House Birmingham Hippodrome Everyman Theatre, Cheltenham Gala Durham Grand Opera House, York Hall for Cornwall, Truro Mayflower Theatre, Southampton Sunderland Empire The Lighthouse, Poole The Lowry, Salford Theatre Royal Nottingham Theatre Royal Plymouth Theatre Severn, Shrewsbury Wales Millennium Centre, Cardiff Wycombe Swan, High Wycombe By showCompany Class First Steps: a child's Swan Lake North tour spring 2015 Pre-performance talk South tour spring 2015 Swan Lake Sylvia The King Dances / Carmina burana Variations triple bill (tour) |
Booking for Three of a Kind at Birmingham Hippodrome
PricingWednesday 19 February, 7.30pm; Thursday 20 February, 2pm £32.50, £29, £25, £20, £17, £15 Thursday 20 February-Saturday 22 February, 7.30pm & Saturday 22 February, 2.30pm £47, £40.50, £34, £26, £19.50, £16 ConcessionsFamily tickets Two Under-16s attend for half price with every adult paying full price (price bands B and C only; excludes Saturday evenings; you are advised to book early to be sure this offer is available). Groups Groups ten+ (eight+ on Triple bill performances): £4 off; Groups 20+: £5 off; Groups 35+: £6 off plus one ticket free for the organiser; call 0844 338 7000, MondayFriday, 10am5pm (TuesdayFriday performances and Saturday matinees; price bands AC; transaction charge included). People with disabilities £5 off tickets in all areas, or two tickets for the price of one for those with disabilities who require the support of a companion. Claimants, full-time students, passport-to-leisure Best-available seats for lowest full price, may be available from 24 hours pre-performance. Maximum two tickets per booker. Over-60s, 18 and under, claimants, full-time students and passport-to-leisure £3 off tickets TuesdayFriday evenings, weekday and Saturday matinees (price bands AC). School and youth groups of ten or more Weekday matinees only; £10.50 per ticket (transaction charge included); one teacher attends for free with every ten tickets purchased (price bands CE only; transaction charge included). BRB Friends TuesdayFriday evenings: £5 off price band A; £4 off price band B; £3 off price band C (one ticket per member, limited availability, available by telephone and in person). |
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