text:
• product Info •
- Fact sheet
- Weight 2400
Heat moldable, multi-density foam throughout the entire liner with removable ankle inserts for even more customized hold.
The dual zone brother to our Quicklock lacing—ZoneLock offers a lower zone locker on the side of your boot in addition to our locker on the tongue. Customize your fit, one zone at a time with optimal wrapping support and outstanding heel hold.
4 levels of construction based on the same design philosophy. Displacing liner lace pressure from the top of your foot, around the key holding areas of the arch and above the heel. Tightening the liner lace now wraps the ankle firmly, yet comfortably.
RELIEF THROUGH REFLEXOLOGY: The only antimicrobial footbed in snowboarding that increases blood circulation, prevents fatigue and embodies natural healing from the bottom of your feet to the top of your head. Better smelling feet are one step away with Mystic's Bamboo based anti-microbial powers.
Heavy duty Freestyle flex!
The Empire offers a street shoe aesthetic, but with on-hill performance hidden all over. The comfortable EVA foam is given a unique wave shape, which promotes natural movement, offers unmatched dampening in the heel, and a thinner forefoot for increased board feel.
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text:
Celebrity Cruises, Inc.: A Taste of Luxury
Frances X. Frei, Corey Hajim, Christian Hemphell
Revision Date:Sep 08, 2005Publication Date:Apr 22, 2003Discipline:Service ManagementSource:Harvard Business School |
Product number:603096-HCB-ENG Length:30p |
English Hardcopy Black & White
Also Available in:
English Hardcopy Black & White | $ 6.93
Taught in the second module of a course on Managing Service Operations, which addresses the design of sustainable service models (606-031).
Describes the complex operations of the cruise industry. Positioned between luxury cruise lines and mass market lines, Celebrity struggles to find ways to create customer loyalty and increase profitability.
learning objective:
To illustrate the complexities of cruise industry operations and middle market positioning.
subjects covered:
Customer satisfaction; International operations; Loyalty; Market positioning; Multibranding; Net profit; Profitability; Strategic positioning
- Geographic: United States
- Industry: Arts, entertainment & sports
- Industry: Travel services
- Company Employee Count: 200
- Company Revenue: $13.49 billion revenues
- Event Year Begin: 2003
- Event Year End: 2003

subset: commoncrawl


text:
Israel News - Stay Informed, Pray Informed
3rd Jonathan Desert Camp 2005 From July 31st to August 14th! Take part in the Adventure, Worship and Fellowship! Seeking God in the Desert. Trekking, Rappeling, Touring in Jeeps, Mountain Biking and lots of fun! Six days out in the Biblical Desert, sleeping in Bedouin tents, one day snorkeling in the Red Sea in Eilat and seven days in and around Jerusalem.For more information call in the UK: 07947-585-421or visit the Website Jonathan Desert Camp An e-mail contact form for the Adventure can be found on the Website, by clicking on "contact us."Welcome to the Desert. Be part of the Adventure!
Want more news from Israel? Click Here to sign up for our FREE daily email updates
Keep up with events in Israel with our FREE daily email newsletter and special offers.


text:
Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra (RBT)
Recruitment status was Recruiting
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- How to Read a Study Record
Open label pharmacokinetic RBT dose-finding study in young (≤ 5 year old) HIV-infected children receiving a LPV/RTV-based ART regimen and who have a recent history of completing TB treatment.
Condition | Intervention | Phase |
Children With Confirmed HIV Infection Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment |
Drug: Mycobutin |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Pharmacokinetics Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra |
- To assess dosing, pharmacokinetic profile, and safety of rifabutin when given concomitantly with LPV/RTV for 14 days in HIV-infected children age < 5 years. [ Time Frame: 6-12 months ] [ Designated as safety issue: Yes ]
- We hypothesize that a clinically significant drug interaction exists between rifabutin & /lopinavir/ritonavir in young children (age < 5 years) such that rifabutin dosing for concomitant administration of RBT & LPV/RTV needs to be developed [ Time Frame: 6-24 months ] [ Designated as safety issue: Yes ]
Estimated Enrollment: | 40 |
Study Start Date: | November 2010 |
Estimated Study Completion Date: | June 2012 |
Estimated Primary Completion Date: | June 2011 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Rifabutin (Mycobutin)
Rifabutin is a red-violet powder souble in chloroform and methanol, sparingly souluble in ethanol, and very slightly soluble in water. Mycobutin capsules contain the antimycobacterial agent rifabutin, which is a semisynthetic ansamycin antibiotic derived from rifamycin S. Mycobutin capsules for oral administered contain 150mg of rifabutin, USP, per capsule, along with the inactive ingredients microcrystalline cellulose magenesium stearate, red iron oxide3, silica gel, sodium lauryl sulfate, titanium dioxide, and edible white ink.
Drug: Mycobutin
Indication and Usage: Mycobutin capsules are indicated for the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV Infection. Dosage and Directions for use: Mycobutin cab be administred as a single daily dose, independent of meals. In all cases Mycobutin is to be administred in combination regimens. Identification: Red-brown, self locking, hard gelatin capsule, size 0, containing a violet powder. |
Show Detailed Description
Ages Eligible for Study: | 5 Years to 18 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Children with confirmed HIV infection. Confirmation can be by two rapid tests (children age > 18 months) or virologic test (children < 18 months), and detectable viral load prior to starting ARVs.
- Age ≤ 5 years old - rationale: changes in body composition and maturity of metabolizing enzymes and organs result in age-related differences in drug clearance, especially between children ≤ 5 years and children > 5 years of age.
- Receiving an ART regimen containing 2 NRTIs + LPV/RTV at standard dose
- Successfully completed TB treatment in the past 2 to 6 weeks. Successful completion of treatment will be defined as children with good clinical response (resolution of TB symptoms) to treatment.
- RBT has not yet been approved for treatment of TB in children. Participating children can therefore not be in need treatment for TB as this may lead to substandard treatment.
- RBT monotherapy in the presence of Mycobacterium tuberculosis can lead to the development of resistance. Excluding active TB is difficult in children, especially those that are HIV co-infected. Children who have just successfully completed a treatment for TB can be assumed to be free of Mycobacterium tuberculosis.
- A minimum of two weeks is needed between RIF and RBT administration to ensure wash-out of any enzyme inducing effects of RIF.
Exclusion Criteria
- History of symptomatic clinical hepatitis during TB treatment
- Abnormal liver function defined as ALT > 2.5 times the normal upper limit (corresponding to the US National Institute of Health Division of AIDS scale grade 2)
- Abnormal bilirubin defined as > 1.5 UNL (≥ DAIDS grade 2)
- Abnormal serum creatinine defined as >1.1 x ULN
- Anemia defined as hemoglobin < 8gm/dL
- Neutropenia defined as < 1.0 x 109/L(corresponding to grade 2)
- Abnormal platelets defined as <125 x 1012/L
- Pre-existing eye conditions
- Any condition that the clinician feels would predispose the child to toxicity
- Children required to take any drug known or predicted to interact with rifabutin (see appendix)
- Children who do not meet inclusion criteria and/or whose parents refuse consent.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01259219
Contact: Shobna Sawry, MSc (Med) Epi & Bio BScHonours | 27119339629 | firstname.lastname@example.com | |
Contact: Annelies Van Rie, MD & PhD | +1919 9661420 | email@example.com |
South Africa | |
Harriet Shezi Children's Clinic | Recruiting |
Johannesburg, Gauteng, South Africa | |
Contact: Sonwabo Lindani, RN 27 11 933 9392 email@example.com | |
Contact: Merleesa Govender 27 11 933 9630 email@example.com | |
Harriet Shezi Children's Clinic, Chris Hani Baragwanath Hospital, WHI, University of the Witwatersrand | Recruiting |
Johannesburg, Gauteng, South Africa, 1864 | |
Contact: Hermien Gous, PharmD 27119388189 firstname.lastname@example.com | |
Harriet Shezi Children's Clinic, Chris Hani Baragwanath Hospital, WHI, University of the Witwatersrand | Recruiting |
Johannesburg, Gauteng, South Africa, 1864 | |
Principal Investigator: Henry (Harry) AJ Moultrie, MD |
Principal Investigator: | Henry (Harry) JA Moultrie, MD, Master's in epi | Harriet Shezi Children's Clinic, Chris Hani Baragwanth Hospital, WHI, University of the Witwatersrand |
No publications provided by Harriet Shezi Children's Clinic
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Dr Harry Moultrie, Harriet Shezi Children's Clinic, Chris Hani Baragwanath Hospital, WHI, University of the Witwatersrand |
ClinicalTrials.gov Identifier: | NCT01259219 History of Changes |
Other Study ID Numbers: | Rifabutin (RBT) |
Study First Received: | December 13, 2010 |
Last Updated: | December 13, 2010 |
Health Authority: | South Africa: Human Research Ethics Committee South Africa: Medicines Control Council |
Keywords provided by Harriet Shezi Children's Clinic:
HIV Completion of TB treamtment |
Additional relevant MeSH terms:
Rifabutin Anti-Bacterial Agents Anti-Infective Agents Antibiotics, Antitubercular |
Antitubercular Agents Pharmacologic Actions Therapeutic Uses |
ClinicalTrials.gov processed this record on May 05, 2015


text:
But you're quite salty though
So I say Jets fanWho do you support then? And why hate Eli so much, arguably one of the most clutch QB's ever
Just hate him because hes was bitching and crying about going to Chargers. Hes a good quarterback but I couldn't stand him just because of that fact. Hes my least favorite Manning. I also hate the Jets too because of their organization and New York fans in general. I think its pretty convenient that if one team does good and the other does bad,fans can jump ship at any time. Im a Houston Texans fan.
What does that even matters now?
Specially since you say you're a Texans fans. I mean it's 2012, you should be hating Tebow not Elite Manning aka Tom Brady Killer aka Joe Montana's favorite bastard child.
I cant hate Tebow,thats like hating Jesus. Dont really hate Sanchez either,hes fucking incompetent. I hate Brady because hes fucking perfect. The Pats are the only team that is really standing in the way of a Texans appearance in the SB. Ravens are old as fuck,Steelers dont have shit. Colts have a rookie QB and I dont care how good Luck is,They aint getting pass the Texans D.


text:
Top Definition
A card game similar to Rummy, popular among urban youth. It is usually played for low stakes, most commonly one dollar. Players try to get spreads of three until they either 1) Drop, thinking they have the lower hand or 2) Tonk out, when they play all their cards. Also called tonk
James: Any of y'all play dolla game?
Guy: You got cards, nigga?
James: No...
Guy: You got cards, nigga?
James: No...
by XdElIrIuM
April 28, 2004


text:
First off, this is about the most sensible post in this whole thread. You put your finger on the issue correctly with the last sentence.
That being said; the API does not need to be stable, it should evolve naturally. But it will automatically and naturally become more stable and future-proof if developers do spend more than 2 seconds thinking about their interfaces. Everything else comes from there, naturally, and almost painlessly (it is less painful than the current situation, that's for sure).
Everybody could win, if only the supposedly more clued people would spend some time using that bigger brain that they are supposed to have. Or put differently: by continuing to refuse to work like this, those refusing only prove that they are not deserving of the status that they like to claim for themselves.
Some backports for some distributions is rather limiting.
What we need is driver developer provided backwards compatibility (with some features disabled) for some distributions: ideally, compatible with debian stable. The likes of Redhat, Canonical and SuSE can then do the rest of the work for their older enterprise releases (for which they get paid). The job of supporting such older infrastructure will also be overseeable in such a constellation.
This way, every user can do one of the following to get drivers installed:
1) install packages built by distribution maintainers, who also have an easy task, so updates are plenty and frequent
2) build driver stacks from source for a reasonably current distribution
3) spend some time on getting the code compatible
4) buy support
5) update infrastructure
6) use a closed driver (for the sake of argument)
Depending on different user classes, you can then start guessing at the numbers.
Phoronix users:
1) 5% -> 50%
2) 10% -> 20%
3) 5% -> 2%
4) 5% -> 3%
5) 25% -> 5%
6) 50% -> 20%
Other hobby users:
1) 25% -> 60%
2) 5% -> 10%
3) 0% -> 0%
4) 10% -> 5%
5) 20% -> 5%
6) 40% -> 20%
Corporate users (admins doing the work):
1) 30% -> 75%
2) 20% -> 10%
3) 0% -> 5%
4) 20% -> 5% (little extra support needed for graphics drivers, but the support will be bought anyway for other issues)
5) 10% -> 0%
6) 20% -> 5% (most use intel hw anyway)
(would be nice to collect real figures though)
Guess what, those selling support will actually fare better:
* the user experience will vastly improve
* the market share will also improve (over time, we made a horrible impression so far)
* the manpower needed to provide graphics driver support will be reduced and can be rerouted to do more useful things
And, for graphics driver developers, there are the following advantages:
* vastly increased userbase for recent code: better testing!
* easier direct debugging: testing different versions of both driverstack and infrastructure is feasible
* easier user debugging
* less time spent dealing with bugs and support, more with development (but slightly more time will be needed there anyway)
* more pressure for closed vendors to open up
* bigger market share for free software
All that takes is the willingness to state: "Yes, we support up to debian stable", and to make that happen. When given the ability, users will then provide loads of testing, and will make sure that such support is not broken easily.
That's what distributions are for.
No, this is our job, and we blew it for Sandy Bridge. We're supposed to do development well ahead of product release, and make sure distros include the necessary code to get things working (we have separate teams to do development and aid distros in backporting, though most of them can handle it by themselves these days).
I could give you all sorts of explanations as to why this is (Sandy Bridge is a big architectural change, we made some mistakes in defining our development milestones, and we didn't work hard enough to get our changes backported), but really there's no excuse. Fortunately we've learned from this and are giving ourselves more time and planning better for Sandy Bridge's successor, Ivy Bridge.
As for a stable ABI, yes it would definitely help situations like this and make lives easier for distros, device manufacturers, and probably users. But it would make life harder for developers, and as we all know, open source development is driven by developers, and we're a whiny and lazy bunch. (Yes, this is a flippant remark, don't take it too seriously since I omit much of the complexity behind the "life harder for developers" part that has big implications for users, distros, and device manufacturers; it's a complicated issue.)


text:
News Archive
Congratulations to the naked mole rat, which was recently named the Vertebrate of the Year by Science Magazine! Naked mole rats have carved out a reputation for healthy living; they can last as long as 30 years and stay healthy right up to the end-and that includes never getting cancer.
Thursday, January 2, 2014 - 15:28
For all the weird and wonderful diversity of the animal kingdom, at the genetic level many species have a surprising level of similarity.
As a result we can learn a lot about the inner workings of our own human cells by studying other animals, and not all of them are mammals as you might expect.
Tuesday, December 31, 2013 - 15:00
The tropical zebrafish is the unlikely hero in providing hope for a different future for Charlie who has Duchenne Muscular Dystrophy (DMD).
Friday, December 20, 2013 - 15:53
New research by scientists in Germany - using a modified enzyme to kill HIV - is providing renewed hope that people living with the virus can be cured.
Thursday, December 19, 2013 - 16:41
A tiny, transparent fish embryo and a string of surprises led scientists to a deeper understanding of the perplexing link between low calcium and colon cancer.
Wednesday, December 18, 2013 - 16:11
On a recent visit to a laboratory where he researches obesity, Kevin Corbit walked over to one of the patients he is studying to say hello. Then he clasped a claw.
Dr. Corbit, a scientist at drug maker Amgen Inc., AMGN +0.38% is conducting his research on grizzly bears. He believes insights gleaned from the animals, who can take in as much as 58,000 calories in a day and weigh 1,000 pounds, could reshape understanding of obesity and identify new treatments for a condition that has stymied doctors and drug developers.
Monday, December 16, 2013 - 14:52
A team led by a longtime Oregon Health & Science University researcher has demonstrated in mice what could be a revolutionary new technique to cure a wide range of human diseases — from cystic fibrosis to cataracts to Alzheimer's disease — that are caused by "misfolded" protein molecules.
Wednesday, December 11, 2013 - 17:04
People with early signs of multiple sclerosis who were treated with a vaccine used to prevent tuberculosis were less likely to get sick than patients who weren't vaccinated, according to an early study.
Friday, December 6, 2013 - 15:00
Dogs with the bleeding disorder haemophilia A have been successfully treated by gene therapy, according to US scientists.
Two of three dogs given the experimental treatment remain free of severe symptoms more than two years on, they write in Nature Communications.
Wednesday, November 20, 2013 - 16:48
Nick Jeffery, professor of neurology and neurosurgery in the ISU College of Veterinary Medicine, said the new treatment methods he's studying in dogs can offer a more realistic picture of how humans would respond to new treatments than laboratory experiments on rats, a much more widely used method of gathering data on new medical procedures.
The tightly controlled laboratory conditions for rodents bear little resemblance to the clinical reality of human spinal injuries. But pet dogs that spontaneously suffer spinal injuries can offer a much closer match, Jeffery said.
Nick Jeffery, professor of neurology and neurosurgery in the ISU College of Veterinary Medicine, said the new treatment methods he's studying in dogs can offer a more realistic picture of how humans would respond to new treatments than laboratory experiments on rats, a much more widely used method of gathering data on new medical procedures.
The tightly controlled laboratory conditions for rodents bear little resemblance to the clinical reality of human spinal injuries. But pet dogs that spontaneously suffer spinal injuries can offer a much closer match, Jeffery said.
Friday, November 15, 2013 - 14:35
The nine-banded armadillo (Dasypus novemcinctus) has many hidden skills—it can sniff out insects buried 20 cm underground, for example, and jump more than a meter into the air when startled. Seeing, however, is not one of its natural talents. Because its eyes lack light-detecting cells called cones, it has fuzzy, colorless vision. The light-receptive cells that an armadillo does have, called rods, are so sensitive that daylight renders the nocturnal animals practically blind. But the deficit may have a silver lining for humans. To study diseases that cause blindness in people, scientists typically genetically "knock out" cone-related genes in animals like mice. Such studies are limited, because they examine only one gene at a time, when a number of different genes contribute to cone dysfunction, researchers say. By comparing the armadillo gene to other closely related mammals, a team of scientists has now identified several cone-related genes in the armadillo genome that became nonfunctional millions of years ago, they report today at the Society for Neuroscience conference in San Diego, California. This makes the animals "excellent candidates" for gene therapy experiments that could restore color vision and point the way to potential human treatments, they say.
Tuesday, November 12, 2013 - 16:51
Skeletal muscle has proved to be very difficult to grow in patients with muscular dystrophy and other disorders that degrade and weaken muscle. Researchers at Boston Children's Hospital's Stem Cell Program now report boosting muscle mass and reversing disease in a mouse model of Duchenne muscular dystrophy, using a "cocktail" of three compounds identified through a new rapid culture system. Adding the same compounds to stem cells derived from patients' skin cells, they then successfully grew human muscle cells in a dish.
Friday, November 8, 2013 - 17:15
While human doctors and veterinarians are usually thought to keep to their own corners of the animal kingdom, more are seeing the same maladies in their patients – from breast cancers to addictions to eating disorders – causing the two disciplines to increasingly team up to crack medical mysteries.
Monday, November 4, 2013 - 15:03
Researchers frequently investigate animal-derived compounds and determine their usefulness as treatments for human ailments. Examples of success stories include bat saliva used as an anticoagulant in stroke patients, centipede venom as a potent painkiller, and intestinal parasites combating rheumatoid arthritis, diabetes, lupus and more.
Friday, November 1, 2013 - 16:18
An experimental drug called 3K3A-APC appears to reduce brain damage, eliminate brain hemorrhaging and improve motor skills in mice that have been afflicted by stroke, according to a new study from Keck Medicine of USC. The report provides additional evidence that 3K3A-APC may be used as a therapy for stroke in humans.
Friday, October 25, 2013 - 12:54
With help from mice, researchers from St. Jude's Children's Research Hospital have discovered a way to develop a universal flu vaccine that could protect against the most common strains just as much as the deadliest pandemic strains.
Tuesday, October 22, 2013 - 14:32
Scientists studying tiny zebrafish have uncovered a way to slow the growth of liver tumours by up to 30 per cent, simply by "switching on" a key protein called Rho.
Monday, October 21, 2013 - 15:42
One might wonder why researchers would even care about the nuances of the one-millimeter long nematode worm, let alone take the time to study them. But the answer is simple: they can provide powerful insights into human health and disease.
Wednesday, October 16, 2013 - 15:09
The government shutdown is likely to mean an early death for thousands of mice used in research on diseases such as diabetes, cancer and Alzheimer's.
Federal research centers including the National Institutes of Health will have to kill some mice to avoid overcrowding, researchers say. Others will die because it is impossible to maintain certain lines of genetically altered mice without constant monitoring by scientists. And most federal scientists have been banned from their own labs since Oct. 1.
Friday, October 11, 2013 - 15:49
The 2013 Nobel Prize honours three scientists who have solved the mystery of how the cell organizes its transport system.
Monday, October 7, 2013 - 15:56


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text:
Installation packages for Audacity on GNU/Linux and other Unix-like systems are provided by individual distributions. The following distributions maintain regularly updated Audacity packages:
- Fedora
- Gentoo
- SuSE/Open SUSE
- Ubuntu:
- packages.ubuntu release packages.
- daily PPA packages built from Audacity SVN development code. Note: These should not be used as your production version of Audacity.
- rpmseek for legacy Audacity packages.
Otherwise, we recommend either searching the web pages of your distribution for the latest information, or compiling Audacity yourself from source code.


text:
What we really need is someone with Steam experience to speak up and tell us what card they use. I can only speak theoretically. I know through a friend that GT610s work fine (Xubuntu 12.10) for normal desktop work and multi-monitor works with the Nvidia driver. Personally I run HD2000 graphics - but have no interest in games. I do not think KMS is really a problem once the Nvidia driver loads and you reach the log in screen. Unless there is some other issue with Steam and Wine. Is KMS really an issue that matters?
Putting an Nvidia card on a motherboard with integrated Intel is not the same thing as Hybrid graphics. In your case the Intel will no longer exist (to the system) once you plug in the Nvidia card and Bumblebee is not relevant.
Last edited by grege; 01-10-2013 at 05:46 AM.
I have no idea about KMS, I'm not a particularly advanced user, I just read what @Vincent wrote about KMS console and I thought I should ask what he meant by that.
Like I said, on 2000HD, Team Fortress works fine, Serious Sam is relatively OK to play, Amnesia runs but there's flickering. Maybe I'll postpone upgrade until Steam matures more, or drivers perhaps....Thanks everyone for your input.....
You have Intel 2000HD? How does the rest of your setup look like? Which distro are you using?
I have the Xorg Edgers ppa, Mint 13 KDE 64bit with the latest kernel, I did dist upgrade. Before that Amnesia wouldn't work at all, in Serious Sam everything was black and white, out of whack basically and I didn't try Team Fortress, so I can't comment on that. But after upgrades situation is much better. Or maybe I don't have Intel 2000HD, I'm pretty sure that when I was buying components for my rig that It was Intel 2000HD on Celeron G530.
Code:$ lspci | grep VGA 00:02.0 VGA compatible controller: Intel Corporation 2nd Generation Core Processor Family Integrated Graphics Controller (rev 09)
GT730 should be 28nm card unlike retail GT630, which is rebranded GT440.
Nvidia is already producing 28nm GT630, but it is OEM only.
Is this the best card if you want something cheap that has hardware decoding, passive, quiet and compact/low profile?
I read on the OSS (ATI/AMD) radeon thread that those drivers are still iffy although I only read of one post in which the thermal features weren't working (integrated hardware on a laptop).
However, with an AMD card, I guess having hardware accleration is out the window (meaning no option for it), right? Even for the proprietry drivers. My current Nvdia card will be legacy driver status or it is already. The GT 610 is $20 with rebate and the Radeon HD 6450 is around $30.
I don't need the card for gaming as I won't have time for that. Which is the better choice for watching videos/movies/htpc and having a quiet card that has less video issues and more (most?) options? I'd like to go open source but AMD refuses to support hardware decoding and many other features in Linux.
Both cards are not for gaming at all. If you want to use vdpau for xbmc or so go for nvidia. Also you get more often driver updates with support for new kernels and xservers. If you intend to play get something faster, maybe gt640+.


text:
Position: | Assistant Coach |
EXP: | First Season |
Juan Florez, who competed for the Matadors during the 1987 season, is in his first season as assistant coach for the Matadors. He has also been an assistant at CSUN in the past and was most recently the head coach of the Los Angeles Blues of the United Soccer League (USL PRO). Florez will be in charge of the offense.
"Juan is very well known in the soccer community for developing youth talent to play at the highest level and he helped run our offense in 2005 when we made the NCAA Tournament," said CSUN men's soccer head coach Terry Davila. "He is very good with the players in bringing out their potential, which is a reason our team had the second-ranked scoring offense in 2003."
As a player at CSUN, Florez collected 30 points in his lone season with the Matadors. He scored 10 goals and added 10 assists on the year as Northridge advanced to the NCAA Division II National Championship match.
As a Coach
-1996 to 1998 San Fernando Valley Eagles – Head Coach (Playoffs 2 years )
-2007, 2008 San Fernando Valley Quakes – Head Coach (First place conference both years)
-2012 LA Blues – Assistant Coach.
-2012 LA Blues – Head Coach
-1992 assistant coach at CSUN
-2000 to 2006 Men's offensive assistant coach (2005 Number 1 offense in NCAA)
-2013 Men's offensive assistant coach
- AYSO / Sherman Oaks, Balboa, Mission Hills, Granada Hills – Train All star teams, coaching clinics, player clinics.
- WVSL / Director of coaching
- Club soccer – Valley United, LA Force, Rovers SC, Samba, Real SOCAL, North Valley Soccer Club.
- 2008-2012 Sierra Canyon Schools – Head of soccer
As A Player
- 1983 Glendale College (state champions / 1st team defense)
- 1987 CSUN (NCAA runners up)
- 1988 Professional Reserve teams:
Club Millonarios / Bogota,Colombia
Club America / Cali, Colombia


text:
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The original deal pioneer keeps on pinching pennies and cracking wise. No, that price isn't a typo.
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klezman wrote:I'm nearly in on the strength of this analogy alone.
me too
kagayaki1 wrote:(Delille Cellars) Doyenne Signature Syrah sources fruit from Boushey (Yakima) and Grand Ciel (Red Mountain). Both vineyards are exceptionally managed and produce great fruit. Albeit expensive. In my opinion, from tasting the 2008 Doyenne Signature recently: the Doyenne has more black tea and floral notes, with a much rounder, softer mouthfeel. It also has more alcohol, but it's in balance, so it adds to the lush mouthfeel (probably the glycerols). The color is just about as dark, but more red than violet. I think you'll find the Cougar Crest to have more oak on the lower end, more purple color, and while the mouthfeel will not be quite as polished, it will have an aggressive, bold nose, more smoked meat notes backed by an unmistakeable cool rock minerality sense. I personally like Syrah that shows extreme sense of place. Cougar Crest's higher end offerings do that. Put it this way: Doyenne is what I'd order at a business dinner, but Walla Walla Syrah is what I ordered in my head. Also for anyone doing CA comparisons, this is the exact opposite of Paso Robles Syrah. Cougar Crest Syrah is as cool as the other side of the pillow.
Thank you! That was amazingly helpful!
You're all too kind, no problem at all. Wine.woot has offered some interesting new wines I've enjoyed in the past, so I feel like I have to contribute when Washington and Oregon wines show up (my area of expertise).
kagayaki1 wrote:You're all too kind, no problem at all. Wine.woot has offered some interesting new wines I've enjoyed in the past, so I feel like I have to contribute when Washington and Oregon wines show up (my area of expertise).
You've done quite a fine job contributing today. Thanks for all the info!
I recently had a syrah from walla walla at a restaurant that was absolutely delicious. I can't remember the name although I remember confusing the label for a old style french wine. It was smokey and earthy with some dark fruit and mild tannin. It was very different from the Australian or Cali style and so good that we ordered a second bottle finishing the restaurant's supply (at $60/bottle). Based on that bottle and the descriptions on this thread, I'm in for a set even though it is a little above my normal price range. Edit: Speed to first woot: 6m 31.662s First sucker:unixguru Last wooter to woot:burrnini Last purchase:a few seconds ago
Guest Blogger
Having dinner with a friend of mine in the wine industry (VML Winery in Healdsburg) and we just had the Golden's Legacy open with dinner. We both agreed that the wine was wonderfully balanced, elegant- 'the kind of Syrah you want to home to". Dark fruit enveloped in a light, floral layer (that 3% Viognier). A wonderful wine. We chased it with a big, Paso Syrah (15.3) and the Paso wine fell flat in comparison (and I like said Paso Syrah!) Interesting cool climate/warm climate comparison. Verdict- Cougar Crest rocks.
I really want to be in on this, and already regret the no buy. Circumstances with finances and storage preclude it. That said, I hope to see a small amount during a woot off or something in the future. I have really enjoyed all the CC wines I have had, especially their Cab Franc! I dig cool climate syrahs and know this would be up my alley... If you are on the fence and have the space, do it.
kylemittskus wrote:You've done quite a fine job contributing today. Thanks for all the info!
Kyle's account has been hacked! ;)


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Explore the art, philosophy, politics, and psychology of video games with some of the medium's most influential designers and visionaries.
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Tribe on a quest to maintain winning ways
A's send Milone to cool off Indians, who have won seven of eight
Let's just let A's manager Bob Melvin explain how the Indians are playing right now.
"I mean, you look at the numbers, offensively right now, a lot of guys are swinging the bat really well," said Melvin, whose club continues a four-game series with Cleveland on Tuesday.
The Indians, following Monday night's victory over the A's, have won seven of their last eight. They're six games into a nine-game homestand during which they're hitting .351, including a .344 mark with runners in scoring position.
Going back even further, they've hit at least one home run in seven of their last eight games, totaling 19 in all.
"We would have preferred to catch them a little earlier in the season," Melvin said. "Their lineup looks much better than it did last year, across the board. They just look like a different team, and certainly a good team."
A's left-hander Tommy Milone is the next pitcher in line hoping to silence the Indians' hot bats, and he will oppose Indians right-hander Zach McAllister. Milone, 26, has pitched well in his past three starts, posting a 3.54 ERA and 1.13 WHIP in that span, but took the loss in each of those outings. He fared well against the Indians last season, going 1-0 with a 3.27 ERA in two starts.
Whereas Milone was solid against the Indians last year, McAllister was anything but against the A's. McAllister went 0-1 with a 7.84 ERA in two starts against Oakland last season, but he's coming off his best outing of 2013, having held the Phillies to two runs in seven innings his last time out.
A's: Balfour perfect
Closer Grant Balfour has a streak of 23 consecutive saves, the third longest in Oakland history. He has not blown a save since April 29, 2012.
• A's pinch-hitters are 2-for-31, with two walks.
• The A's are 13-3 against the American League West, compared with 5-12 against the rest of baseball.
Indians: Holding the lead
The Indians have suffered a loss after holding the lead at some point in the game only twice this season, tied with the Yankees, Rangers and Nationals for the fewest such defeats in the Majors.
• Cleveland has been .500 or better for four straight days.
• Ryan Raburn earned his first AL Player of the Week Award on Monday after batting .591 with four home runs and nine RBIs in five games.
Worth noting
• The A's won the season series last year, 8-2, winning eight straight after losing the first two.
• Milone has a 6.17 ERA and .313 average against in two road starts this season.
• Oakland's Brandon Moss is batting .417 on the road.
Cash Kruth is a reporter for MLB.com. Follow him on Twitter at @cashkruth. This story was not subject to the approval of Major League Baseball or its clubs.


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There are two strip club myths: that all strippers are crazy and that there's no sex in the champagne room. Teenage stripper Torrie Madison blows at least one of those out of the water. Torrie is crazy -- but only for cock and if you catch her on the right night, she might just give you a handjob in the corner or let you leave your jizz dripping off her face in the champagne room. Torrie isn't shy about loving cock, so before she got down to sucking, we let her play with it, stroke it, and slap it against her wet pussy just to get her primed for the milk mustache we were going to give her. I think I see an 18 year old stripper in my future. I've got a pocket full of sticky dollar bills and Torrie Madison on my mind!
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Mason Pearson Pure Bristle Brush Pocket Size
Kathleen S.SeattleHairAuburnThick or Coarse HairQuality ProductThe craftsmanship of the brush is excellent. Seems durable. Nice compact size for travel, yet the bristles are strong enough to get through thick hair. Price seems high for the item, even considering the quality materials.posted Feb 15, 2013Link to this post
ChristieHairLight BrownFine or Thin HairA Must Have For Me!I have fine hair, but a lot of it, that's a few inches below my shoulders. My hair tangles so easily that I find myself brushing through it 5-10 times a day- that's a lot! That's why I decided to find the best possible brush for my hair so I wouldn't damage it with all the brushing. I did a lot of research and ended up going with the Mason Pearson Pure Bristle Brush in Pocket Size. I don't really know why anyone would need a bigger size than this, I guess maybe if their hair is really thick, but this one works just fine for me and it's the least expensive of the Mason Pearsons. I've had this brush for over two years now and use it every time I brush my hair. I love it! Unlike most brushes I've used, this one goes through all my hair and touches my scalp. It's like an awesome scalp massage every time I brush! It's also really good at redistributing oils at the scalp, which helps to condition the hair strand. This brush leaves my hair smooth and shiny. I came to this website today to get a second brush that I can just keep at home, because the one I have now I use at home and for travel. The only drawback for me is that the brush does get kind of gunked up with the debris in your hair, and I end up cleaning it with my fingers or tweasers to get it out. The larger sizes come with a brush you can use to clean your brush, but not this one. Of course, that would happen with any brush, so I didn't knock off any stars for that. If you brush your hair a lot like me, invest in a good brush and you won't be sorry!posted Dec 17, 2011Link to this post
TjBristles Falling Our After A Few YearsDefinitely not an "investment" caliber brush. My bristles started falling out a few years after I bought this brush.posted May 10, 2010Link to this post
ValerieSan Diego, CaSuper Satisfied!This is far and away the best brush Ive ever used. It goes through my fine, easily tangled hair effortlessly. My hair has more volume and shine when I brush than ever before. Folica is a wonderful website that provides a very pleasant shopping experience. Highly Recommend!posted Feb 5, 2008Link to this post
MhgDallas, TexasThe Classic...and Still The Best!This compact version of the original dresser-top brush has the same remarkable effect: hair softens, shines, detangles and styles like no competitors tool can accomplish! Small enough for a purse, but big enough for even medium-length hair, this light-weight brush fits the hand perfectly, while having a dainty, professional look. No woman of substance should be without one.posted Jan 26, 2006Link to this post
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H.R.3261 - Stop Online Piracy Act
To promote prosperity, creativity, entrepreneurship, and innovation by combating the theft of U.S. property, and for other purposes. view all titles (7)
All Bill Titles
- Popular: SOPA as .
- Popular: Stop Online Piracy Act as introduced.
- Short: Stop Online Piracy Act as introduced.
- Official: To promote prosperity, creativity, entrepreneurship, and innovation by combating the theft of U.S. property, and for other purposes. as introduced.
- Popular: Enforcing and Protecting American Rights Against Sites Intent on Theft and Exploitation Act as introduced.
- Popular: E-PARASITE Act as introduced.
- Popular: SOPA.
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…With the passage of legislation censoring the Internet, the battle to stop the barbarian at the gate has only just begun. The purveyors of offensive material will continue their quest to make their material available; in all likelihood the CDA will prove to only be a minor inconvenience. The opponents of on-line censorship have moved on to the next battle field, the court room.(193) The only one leaving the field of battle will be Senator Exon, who announced, prior to introducing his CDA, that he would be among the stampede of Democrats retiring from the Senate this year…
… On June 11, 1996, a three-judge panel in the Eastern District of Pennsylvania found that the Communications Decency Act violated the First Amendment of the United States Constitution…
Let's just face it. Our forefathers did not want this country to be a dictatorship, monarchy, or communist run government. Sometimes I feel this is what it is. Sooner or later we will be controlled on everything we want to do, safe or not, example: this. This is expressing how we feel and what we feel about games, gaming, TV, internet and a whole bunch of things, and yet they do not realize that if they shut it off, they will not be able to use it either. Sooner or later it will be a mixture of a monarchy and a dictatorship. I am not encouraging it, I am simply stating what I FEEL!
Email: email@example.com
Website: http://congressvoters.webs.com
Youtube: http://www.youtube.com/fierylegofuryWith SOPA Shelved, Congress Readies its Next Attack on the Internet
One of the things that became clear in Congress' push to pass Hollywood's web censorship bills is that powerful corporations and the federal government do not want the rule of law to apply on the internet. The attitude that our basic freedoms and legal protections are somehow not valid on the internet is partly just the kind of reaction you would expect from entrenched powers whenever new technologies emerge, but it's also a response to the particular peer-to-peer features of the internet that threaten to make their key sources of power — control of information flow — less relevant.
The Online-Piracy Mess: How Chris Dodd and Hollywood blew it with SOPA
A cool $1.5 million a year.
That's what the Motion Picture Association of America is reportedly paying Connecticut's formerU.S. Sen. Chris Doddto slide an anti-Internet-piracy bill through Congress. His insider knowledge, his old-fashioned liberal credentials, and his winning smile were supposed to make it all so very easy.
Except that Dodd and the MPAA and the hoard of other lobbyists stroking this issue for them now appear to be drowning beneath a tidal wave of Internet opposition. And just maybe Dodd's sweet salary might have been better spent on someone more in tune with 21st Century technology issues than old-fashioned congressional politics…
…Dodd isn't backing away or admitting that he might be to blame for underestimating Internet opposition or the technological fallout from what he and the MPAA have been trying to get through Congress.
For one thing, he points out that he is forbidden from personally lobbying members of Congress until January 2013. But there's little doubt that he was hired to orchestrate the MPAA's lobbying effort and to be the face of the SOPA campaign…
New Iran internet blocking
Some days ago the Iranian government has ramped up censorship in three ways: deep packet inspection (dpi) of SSL traffic, selective blocking of IP Address and TCP port combinations, and some keyword filtering.
Sound familiar??
Spam Comment
Spam Comment
Considering the Network as the radar detector of the Multitude
…The difference between Twitter feeds about speed traps and Wikileaks dumps of the government's classified interoffice memoranda is just one of degree. Without secrets, government must either persuade the populace of its legitimacy, or abandon legitimacy for force of arms. We can expect a decade or two of efforts by governments and other powers (corporations, cartels, and perhaps copyright holders) to try to use law (and force) to prevent the popular use of the network to expose institutional secrets, and it seems certain they will all inevitably fail. Trying to control the use of communications networks is like trying to exterminate the rhizome under your lawn. (Ironic, perhaps, that a technology designed by the military-industrial complex to ensure viable communications in the event of nuclear attack ends up appropriated by the people and able to withstand attack by its creator.) …
Link to above,
In case President Obama chooses to bring back SOPA, we need to stop it. Please sign this petition to demand that Obama drop all support for Internet censorship (such as SOPA):
And here is an article you might want to read:
Spam Comment
Hi, nice post. I have been wondering about this topic,so thanks for sharing. I will certainly be subscribing to your blog.
Hi, nice post. I have been wondering about this topic,so thanks for sharing. I will certainly be subscribing to your blog.


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Jezzcar Jess
Follow Jezzcar21-year-old Female living in Victoria Australia
Hey guys! My name is Jess and I'm a pretty new traveller. I have been overseas only once, but the experience was so amazing that I've been driven to go as many places and experience as many different cultures as I can! I'm really interested in travel (obviously hehe!), music, reading, playing computer games and hanging out with friends and family among other things. :) At the moment I'm curr... More


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The Classic Country Book - Easy Guitar
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The Classic Country Book - Easy Guitar by Various. For Guitar. Easy Guitar. Country and Traditional Country. Difficulty: easy-medium. Easy guitar/vocal songbook (leadsheet notation). Leadsheet notation (includes melody line and chords), chord names, guitar chord diagrams, strum and pick patterns and lyrics. 176 pages. Published by Hal Leonard (HL.702018).
ISBN 0793558662. With leadsheet notation (includes melody line and chords), chord names, guitar chord diagrams, strum and pick patterns and lyrics. Country and Traditional Country. 9x12 inches.
101 country classics: Act Naturally * Cold, Cold Heart * Could I Have This Dance * Crazy * Daddy Sang Bass * D-I-V-O-R-C-E * El Paso * Folsom Prison Blues * The Gambler * Heartaches by the Number * I Fall to Pieces * I'm Not Lisa * King of the Road * Kiss an Angel Good Mornin' * Lucille * Mississippi Woman * Rocky Top * Sixteen Tons * Son-of-a-Preacher Man * When Two Worlds Collide * Will the Circle Be Unbroken * You Needed Me * more.
- Act Naturally Performed by Buck Owens
- Always on My Mind Performed by Willie Nelson
- Amanda Performed by Waylon Jennings
- (Hey, Won't You Play) Another Somebody Done Somebody Wrong Song Performed by B. J. Thomas
- Any Time Performed by Eddy Arnold
- Bouquet Of Roses Performed by Eddy Arnold
- Busted Performed by Johnny Cash
- By The Time I Get To Phoenix Performed by Glen Campbell
- Chug-A-Lug Performed by Roger Miller
- Cold, Cold Heart Performed by Hank Williams
- Could I Have This Dance Performed by Anne Murray
- Country Bumpkin Performed by Cal Smith
- Crazy Performed by Patsy Cline
- Crazy Arms Performed by Ray Price
- Crying My Heart Out Over You Performed by Ricky Scaggs
- Daddy Sang Bass Performed by Johnny Cash
- Dang Me Performed by Roger Miller
- Deeper Than The Holler Performed by Randy Travis
- Detroit City Performed by Bobby Bare
- D-I-V-O-R-C-E Performed by Tammy Wynette
- Easy Loving Performed by Freddie Hart
- El Paso Performed by Marty Robbins
- Faded Love Performed by Willie Nelson, Ray Price
- The Fightin' Side Of Me Performed by Merle Haggard
- Flowers On The Wall Performed by Statler Brothers
- Folsom Prison Blues Performed by Johnny Cash
- (Now And Then There's) A Fool Such As I Performed by Hank Snow
- Funny How Time Slips Away Performed by Willie Nelson, Lyle Lovett, Al Green
- Funny Way Of Laughin' Performed by Burl Ives
- The Gambler Performed by Kenny Rogers
- Gentle On My Mind Performed by Glen Campbell
- Golden Ring Performed by George Jones, Tammy Wynette
- Green Green Grass Of Home Performed by Porter Wagner
- The Happiest Girl In The Whole U.S.A. Performed by Donna Fargo
- Have I Told You Lately That I Love You Performed by Kitty Wells, Red Foley, Gene Autrey
- He Stopped Loving Her Today Performed by George Jones
- Heartaches By The Number Performed by Guy Mitchell
- Hello Walls Performed by Faron Young
- Help Me Make It Through The Night Performed by Sammi Smith
- Hey, Good Lookin' Performed by Hank Williams
- Honky Tonk Blues Performed by Charley Pride
- I Fall To Pieces Performed by Patsy Cline
- I Walk The Line Performed by Johnny Cash
- (I'm A) Ramblin' Man Performed by Waylon Jennings
- I'm Not Lisa Performed by Jessi Colter
- I'm So Lonesome I Could Cry Performed by Hank Williams
- If We Make It Through December Performed by Merle Haggard
- Islands In The Stream Performed by Kenny Rogers,Dolly Parton
- It Was Almost Like A Song Performed by Ronnie Milsap
- It's Not Love (But It's Not Bad) Performed by Merle Haggard
- Jambalaya (On the Bayou) Performed by Hank Williams
- King Of The Road Performed by Roger Miller
- Kiss An Angel Good Mornin' Performed by Charley Pride
- The Last Word In Lonesome Is Me Performed by Eddy Arnold
- Leavin' On Your Mind Performed by Patsy Cline
- Little Green Apples Performed by Roger Miller
- Living Proof Performed by Ricky Van Shelton
- The Long Black Veil Performed by Lefty Frizzell
- Lucille Performed by Kenny Rogers
- Luckenbach, Texas (Back To The Basics Of Love) Performed by Waylon Jennings & Willie Nelson
- Make The World Go Away Performed by Eddy Arnold
- Mama Tried Performed by Merle Haggard
- Mammas Don't Let Your Babies Grow Up to be Cowboys Performed by Waylon Jennings & Willie Nelson
- Mississippi Woman Performed by Waylon Jennings
- My Elusive Dreams Performed by David Houston & Tammy Wynette
- My Heroes Have Always Been Cowboys Performed by Willie Nelson
- Okie From Muskogee Performed by Merle Haggard
- Old Dogs, Children And Watermelon Wine Performed by Tom T. Hall
- Older Women Performed by Ronnie McDowell
- Paper Roses Performed by Anita Bryant
- Pick Me Up On Your Way Down Performed by Charlie Walker
- Rocky Top Performed by Lynn Anderson
- Room Full Of Roses Performed by Mickey Gilley
- Ruby, Don't Take Your Love To Town Performed by Kenny Rogers
- Saginaw, Michigan Performed by Lefty Frizzell
- Satin Sheets Performed by Jeanne Pruett
- She Believes In Me Performed by Kenny Rogers
- She's Got You Performed by Patsy Cline
- Sixteen Tons Performed by Tennessee Ernie Ford
- Some Days Are Diamonds (Some Days Are Stone) Performed by John Denver
- Son-Of-A-Preacher Man Performed by Dusty Springfield
- (I'm A) Stand By My Woman Man Performed by Ronnie Milsap
- Streets Of Bakersfield Performed by Dwight Yokam & Buck Owens
- Sunday Mornin' Comin' Down Performed by Kris Kristofferson
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- The Vows Go Unbroken (Always True To You) Performed by Kenny Rogers
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- Why Me? (Why Me, Lord?) Performed by Kris Kristofferson
- Will The Circle Be Unbroken Performed by Johnny Cash
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- Your Cheatin' Heart Performed by Hank Williams
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Showing 1-14 of 14 items found in Places to Stay
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Rainbow Motel
Modern country motel located 4 miles east of Beardstown and 7 miles west of Virginia on Illinois Rte. 125 in scenic Cass County. We welcome hunters, workmen, and the traveling public.
CITY:Bluff Springs
Sycamore Motor Lodge
2-story facility. Upper level is three efficiency units equipped with microwave, refrigerator, and stove. Monthly and nightly rates available.
River Park Bed & Breakfast
Home features an outside balcony overlooking the Illinois River.
Red Lion Motor Lodge
Rooms equipped with queen sized beds, cable TV, and free local calls. Ground floor building.
The Carriage House
A beautifully decorated Victorian carriage house behind an old home in the river town of Havana. It is a wonderful opportunity to see how life used to be without giving up modern luxuries like cable TV.
Sisson's Country Inn
Large bedrooms, most with private baths. 1st floor is wheelchair accessible. Meeting room with kitchen available. On-site catering for groups by reservation.
Mason City Motel
Family owned facility all on one level with outside entrances. Weekly and monthly rates available.
CITY:Mason City
Stagecoach Inn/ Dunlap House
Built over 150 years ago, this wooden stagecoach inn once stood on Middletown's square, and is rumored to have hosted Abraham Lincoln and Daniel Webster.
RiverBank Lodge
Be inspired by dramatic architectural details and our leather-packed northwoods lodge themed interior spaces. Located on the banks of the Sangamon River, we know you will remember this unique lodging experience!
The Inn at New Salem
Enjoy the environment of this local Inn. Conveniently located near New Salem State Historic Site. Just a short drive from Springfield, IL.
The Oaks
An 1875 Italionate home - 7 rooms with private baths, 2 rooms are suites. The house sits on 5½ acres on a hilltop that overlooks Petersburg.
The Branson House Bed & Breakfast
Enjoy your nights stay in a beautiful 1876 "Eastlake" Victorian Bed and Breakfast located in Historic Petersburg, Illinois near Lincoln's New Salem State Park. This large frame house stands at the top of what is known as "Brahm's Hill", and is located where once stood the home of Dr. and Mrs. John Allen, friends of Abraham Lincoln, who moved to Petersburg from New Salem. A two-storied square pillared porch extends to the roof line. Behind the imposing facade lie an equally imposing series of rooms. This house boasts seven marble fireplaces, four downstairs and three in upstairs bedrooms plus a magnificent wood sculptured fireplace in the main entry hallway. An elevator installed in the 1950's allows for easy access to the second floor bedrooms. Central air and heating has also been installed throughout the house.
The Loft B&B
The Loft Bed & Breakfast is a unique and relaxing retreat featuring the finest amenities in a scenic private setting. Located on 63 rolling acres between the many attractions and tourist sites in Springfield and historic Petersburg, Illinois, You'll see deer, turkey, fox and an occasional eagle from the windows or the deck. Or take a leisurely hike down to the river bluffs. You'll be surrounded by amazing peace and quiet. Enjoy this brand new and spacious B&B, complete with a large living room with leather sofa, chairs and a cozy fireplace. The kitchenette and dining areas will lend the creature comforts of home with a continental breakfast that is ready when you are. There are two sleeping areas that will accommodate six people. The solid hardwood floors add warmth and the bathroom features a custom tiled walk-in shower with a bench for relaxing. Walk outside on your private deck and enjoy a glass of wine with a spectacular second-story view of the countryside.
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- Direct carbon (1)
- NMR spectroscopy (1)
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- Biochemie und Chemie (4) (remove)
- Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch (2007)
- Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and an expression platform. Ligand binding in the aptamer domain leads to conformational changes in the expression platform that result in transcription termination or abolish ribosome binding. The guanine riboswitch binds with high-specificity to guanine and hypoxanthine and is among the smallest riboswitches described so far. The X-ray-structure of its aptamer domain in complex with guanine/ hypoxanthine reveals an intricate RNA-fold consisting of a three-helix junction stabilized by longrange base pairing interactions. We analyzed the conformational transitions of the aptamer domain induced by binding of hypoxanthine using highresolution NMR-spectroscopy in solution. We found that the long-range base pairing interactions are already present in the free RNA and preorganize its global fold. The ligand binding core region is lacking hydrogen bonding interactions and therefore likely to be unstructured in the absence of ligand. Mg2+-ions are not essential for ligand binding and do not change the structure of the RNA-ligand complex but stabilize the structure at elevated temperatures. We identified a mutant RNA where the long-range base pairing interactions are disrupted in the free form of the RNA but form upon ligand binding in an Mg2+-dependent fashion. The tertiary interaction motif is stable outside the riboswitch context.
- Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain (2010)
- Long-range tertiary interactions determine the three-dimensional structure of a number of metabolite-binding riboswitch RNA elements and were found to be important for their regulatory function. For the guanine-sensing riboswitch of the Bacillus subtilis xpt-pbuX operon, our previous NMR-spectroscopic studies indicated pre-formation of long-range tertiary contacts in the ligand-free state of its aptamer domain. Loss of the structural pre-organization in a mutant of this RNA (G37A/C61U) resulted in the requirement of Mg2+ for ligand binding. Here, we investigate structural and stability aspects of the wild-type aptamer domain (Gsw) and the G37A/C61U-mutant (Gswloop) of the guanine-sensing riboswitch and their Mg2+-induced folding characteristics to dissect the role of long-range tertiary interactions, the link between pre-formation of structural elements and ligand-binding properties and the functional stability. Destabilization of the long-range interactions as a result of the introduced mutations for Gswloop or the increase in temperature for both Gsw and Gswloop involves pronounced alterations of the conformational ensemble characteristics of the ligand-free state of the riboswitch. The increased flexibility of the conformational ensemble can, however, be compensated by Mg2+. We propose that reduction of conformational dynamics in remote regions of the riboswitch aptamer domain is the minimal pre-requisite to pre-organize the core region for specific ligand binding.
- 13C-direct detected NMR experiments for the sequential J-based resonance assignment of RNA oligonucleotides (2010)
- We present here a set of 13C-direct detected NMR experiments to facilitate the resonance assignment of RNA oligonucleotides. Three experiments have been developed: (1) the (H)CC-TOCSY-experiment utilizing a virtual decoupling scheme to assign the intraresidual ribose 13C-spins, (2) the (H)CPC-experiment that correlates each phosphorus with the C40 nuclei of adjacent nucleotides via J(C,P) couplings and (3) the (H)CPC-CCH-TOCSY-experiment that correlates the phosphorus nuclei with the respective C10,H10 ribose signals. The experiments were applied to two RNA hairpin structures. The current set of 13C-direct detected experiments allows direct and unambiguous assignment of the majority of the hetero nuclei and the identification of the individual ribose moieties following their sequential assignment. Thus, 13C-direct detected NMR methods constitute useful complements to the conventional 1H-detected approach for the resonance assignment of oligonucleotides that is often hindered by the limited chemical shift dispersion. The developed methods can also be applied to large deuterated RNAs. Keywords: NMR spectroscopy , Direct carbon , detection , RNA
- Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain (2011)
- Riboswitch RNAs fold into complex tertiary structures upon binding to their cognate ligand. Ligand recognition is accomplished by key residues in the binding pocket. In addition, it often crucially depends on the stability of peripheral structural elements. The ligand-bound complex of the guanine-sensing riboswitch from Bacillus subtilis, for example, is stabilized by extensive interactions between apical loop regions of the aptamer domain. Previously, we have shown that destabilization of this tertiary loop–loop interaction abrogates ligand binding of the G37A/C61U-mutant aptamer domain (Gswloop) in the absence of Mg2+. However, if Mg2+ is available, ligand-binding capability is restored by a population shift of the ground-state RNA ensemble toward RNA conformations with pre-formed loop–loop interactions. Here, we characterize the striking influence of long-range tertiary structure on RNA folding kinetics and on ligand-bound complex structure, both by X-ray crystallography and time-resolved NMR. The X-ray structure of the ligand-bound complex reveals that the global architecture is almost identical to the wild-type aptamer domain. The population of ligand-binding competent conformations in the ground-state ensemble of Gswloop is tunable through variation of the Mg2+ concentration. We quantitatively describe the influence of distinct Mg2+ concentrations on ligand-induced folding trajectories both by equilibrium and time-resolved NMR spectroscopy at single-residue resolution.


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18U MICHIANA CRUISERS GOLD DUE TO INJURIES WE NEED A GUEST PITCHER AND MIDDLE INFIELDER FOR ORLAND PARK SPARKS COLLEGE EXPOSURE THIS WEEK(JULY 19-22) in ELGIN, ILL.
No Player Fee, Player and family would pay for their own lodging.
We have been an 18u Gold Level team since 2006.
Website: http://www.eteamz.com/MichianaCruisers/
SPARKS WEBSITE:http://www.orlandparksparks.com
Please Contact Pete Gillis: 574-272-6306, cell: 574-329-0308, cell 574-329-0241
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One sparkling heart-shaped ruby, at approximately .59 carat, is the highlight of this beautiful 14 karat white gold heart pendant. Seventeen round diamonds line the top of the heart at approximately .10 carat total weight. The pendant hangs from a matching 14 karat white gold 18-inch box chain. The total gem weight is approximately .69 carat.Item Number: 41050756
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Wednesday, May 13, 2015
using FedEx 2nd Day.


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Founded in 2000, MakeMyTrip is the pioneer of the Online Travel Industry in India. MakeMyTrip is the dominant market leader with over 50% market share. To date, over two million customerss have bought travel services from MakeMyTrip.
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Bus Operators from Mumbai to Bhavnagar are Abhishek Travel (India), Shrinath Travels, Suvidha Travels, and many more.
I found the booking system on makemytrip simple yet easy to use. Really like the way to narrow down on the buses to book.However the bus was no up to the mark, hopefull the bus wallas will listen to the the customers and run some good quality buses.Overall a 'decent' experiece on bus booking on makemytrip.
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Hi, im looking into buying litespeed for two of my servers but i have noticed that the max request body size is too low for my site (1 gb). Is there any way i can increase it to 7 gb?
should be no problem. lsws admin console ->Server->Tuning ->Max Request Body Size (bytes) the help text: "Max Request Body Size Specifies the maximum size of a HTTP request body. For 32Bit OS, 2GB is the hard limit; For 64Bit OS, it is virtually unlimited."
If I increase it more than 1G it says it is an invalid value. I have seen in your documentation that 1Gb is hard limit.
My lsws version is 64 bit, i have already used 7G, M and normal input (bytes), it says its an invalid value and that it will use the default one. This happends everytime i enter an >1GB value. You can see here http://www.litespeedtech.com/docs/webserver/config/tuning/#maxReqBodySize it says 1GB is the hard limit.
thanks for pointing out, we'll fix the document. the help text in lsws admin console is the latest. your lsws version ? 4.2.1 or 4.1.13 or 4.2.2 or 4.0.20 ?
The problem isn't the help text, is that the wiki document is right. The hard limit is 1GB. Is there any way i can increase this for >1gb?
there must be something wrong on your machine. I tried to change to 7G on lsws 4.1.13 / 4.2.1 / 4.2.2, no problem at all.
/usr/local/lsws/bin/lshttpd.4.2.2: ELF 64-bit LSB executable, AMD x86-64, version 1 (SYSV), for GNU/Linux 2.4.0, dynamically linked (uses shared libs), not stripped
OK, reproduced on 4.2.2 in our lab's 64-bit linux box as well. error message like below always in error_log or error.log every time when restart lsws: will report it to our dev. Thanks.
Thanks for your help, please let me know when this is fixed. I really would like to buy litespeed for my two current servers and for more in a future.
fix is available. do force reinstall 4.2.2 from admin console or '/usr/local/lsws/admin/misc/lsup.sh -f -v 4.2.2' from command line.
It is still not working, i have ran the bash command as root first, it didn't work so i went to the panel and do a force reinstall.


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Magazine Articles | The Georgia Martyrs |
"I receive Thee, the price of my redemption, for Whose love I have watched, studied, and labored. Thee have I preached; Thee have I taught. Never have I said anything against Thee."
~ Johann Feneberg, German Jesuit; upon having his leg amputated below the knee (without anesthetic) after an accident


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From delivering flowers to patients to providing funds for CPR education, Norman Regional's volunteers are vital members of the health system.
During National Health Care Volunteer's Week, which runs April 19 to April 25, Norman Regional Health System is thanking the 340 men, women and teens who serve their community by volunteering at the health system. In 2008, volunteers spent more than 56,100 hours delivering flowers, escorting families, working at the gift shop and providing extra customer service to Norman Regional's patients, families and visitors.
"Norman Regional is grateful to have a team of wonderful, caring individuals who donate their time to the health system," said Wendy Fiebrich, manager of Volunteer Services. "Our patients, visitors and staff appreciate these dedicated individuals and the difference they make in their community."
Not only does the Norman Regional Volunteer Auxiliary donate their time, members also donate money to fund departmental needs. Each year, the Auxiliary provides about $60,000 for items such as testing materials for speech therapy patients, software for pharmacists to use on their PDA's to show drug interactions, CPR supplies for staff education, automated external defibrillators, and much more.
The Auxiliary also gives more than $87,000 to support the Hospitality House, which provides accommodations for Norman Regional patients and their families who live outside of the Norman area.
The Health System will thank volunteers by holding annual volunteer appreciation luncheons. Norman Regional Hospital will celebrate on April 29 with guest speaker Gary England, chief meteorologist for KWTV News 9. Moore Medical Center will hold their luncheon on April 24 with guest speaker Angela Buckelew, Oklahoma City television and news personality.
Ways that you can support your community hospital include:
Contact Kelly Wells
Norman Regional Health System
Office (405) 307.2143
Fax (405) 307.2144
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A slang phrase referring to nausea of such extreme intensity that the physical act of vomiting "feels" comparable to expelling the contents of your viscera or gray matter (brain).
If you drink too much alcohol, you'll be "puking your brains out" in front of everyone.
af David in California
23. oktober 2006


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I have been teaching for 30 years. I have taught Biology I, Honors Biology I, Chemistry, Honors Chemistry, Biology II, and AP Biology.
I teach "commando" style. My students are tired at the end of my class because I push to fill their brain with as much knowledge as possible. I try to employ varying teaching strategies throughout the class to keep my students interested and on their toes. My strength as a teacher and my love involves the lab. I have my students in the lab at least twice a week, and more if possible. I am currently teaching a Biology II Lab Techniques class where we spend about 90% of our time doing lab work.
In my years of teaching, I have been honored many times with local awards such as "Rotary Teacher of the Month", etc. I have been on many committees at the state level to write curricula and guidelines for the science courses taught in our state. I am consistently called upon to offer inservice activities in our school system. All of the above are very nice, but my favorite moments come from the students. I love the "light bulb" moments when I am teaching and see that students are catching on to the concepts. Since I teach mostly 12th graders, it is also extremely rewarding to have them come home from college the year after I taught them and have them tell me how much my class has helped them.
My undergraduate degree is in Biology. I have a Master's Degree in Curriculum and Instruction. I have what is called in our state "Master's plus 30" which is 30 graduate hours above the Master's degree.
My teaching materials and products are the result of 30 years of experience. My materials are standards-based and emphasize inquiry and critical thinking skills. I offer a wide variety of materials that are solid in content, are visually attractive, and best of all, are ready to be copied and passed out to your students.
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I'm 6 months pregnant and getting ready to go on a tropical vacation. I'm really pale and don't want to feel self-conscious about my ever-expanding belly and my pasty skin! Is it OK to use sunless tanner during pregnancy? - Lisa
Although there's no proof that self-tanners are harmful, there haven't been many studies done on their effects on a fetus. But slapping on some self-tanner is far better than lying out in the sun and becoming potentially overheated. (Ultraviolet radiation from the sun can lead to skin cancer, and overheating can increase the risk for birth defects, such as neural tube defects, in the first trimester and dehydration later in the pregnancy.)
When you're in the sun during your vacation, make sure to wear sunscreen, drink plenty of fluids, and don't let yourself get too hot.
You should talk to your doctor before applying any "tan in a bottle." And instead of using self-tanner, you could try applying some bronzer to your face, neck, shoulders, and chest.
Reviewed by: Elana Pearl Ben-Joseph, MD Date reviewed: October 2012


text:
EcoSmart updates the traditional fireplace
Article Summary
November 7, The primal warmth and comfort of an open fireplace is often incompatible with modern housing and contemporary living. EcoSmart Fire is a new product from the Australian-based Fire Company that is environmentally friendly, runs on efficient renewable energy and offers the design flexibility and portability to adapt to today's living environments. The EcoSmart Fire is flue less and does not require any utility connection for fuel supply, which makes it ideal for apartment and city living. Fuelled by a renewable energy (Methylated Spirits), it burns clean and is virtually maintenance free.
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