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Efficacy and Tolerance of the Switch From Enfuvirtine to Raltegravir in Antiretroviral Therapy Regimen in HIV Patients With Undetectable Viral Load (EASIER)
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Switching from enfuvirtide to raltegravir in the treatment of HIV-infected patients who sustain viral suppression with a combination therapy including enfuvirtide (or : with an enfuvirtide-based combination therapy)
Condition | Intervention | Phase |
HIV Infections |
Drug: FTC/TDF + EFV or LPV/R +T20 Drug: FTC/TDF + EFV or LPV/R |
Phase 3 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | Randomized Non-inferiority Study Comparing a Strategy Maintaining Current Enfuvirtide-based Antiretroviral Therapy to a Strategy Replacing Enfuvirtide by an Integrase Inhibitor (Raltegravir) in HIV-1 Infected Subjects With Plasma Hiv-1 RNA Levels Below 400 Copies Per ml.ANRS 138 EASIER |
- comparison of the proportions of virologic failure, defined as two consecutive pVL above 400 cp per ml, through 24 weeks in enfuvirtide-maintained arm versus raltegravir arm [ Time Frame: W24 ] [ Designated as safety issue: Yes ]
- comparison of time to onset of virologic failure [ Time Frame: W24 and W48 ] [ Designated as safety issue: No ]
- proportions of pts with pVL under 50 and 400 cp per ml respectively at week 24 and week 48 ; [ Time Frame: W24 & W48 ] [ Designated as safety issue: No ]
- plasma viral mutations in the event of virologic failure, compared to HIV-DNA archived mutations at baseline; [ Time Frame: virologic failure ] [ Designated as safety issue: Yes ]
- change in CD4 levels [ Time Frame: between W0 and W48 ] [ Designated as safety issue: No ]
- incidence of HIV-related events [ Time Frame: between W0 and W48 ] [ Designated as safety issue: Yes ]
- drug plasma and male genital tract pharmacokinetics; [ Time Frame: W24 & W48 ] [ Designated as safety issue: No ]
- incidence and type of adverse events, including adverse reactions [ Time Frame: between W0 & W48 ] [ Designated as safety issue: Yes ]
- proportions of discontinuing allocated treatment strategy [ Time Frame: between W0 & W48 ] [ Designated as safety issue: Yes ]
- quality of life and adherence [ Time Frame: W4, W12, W24 and W48 ] [ Designated as safety issue: No ]
- morphological and metabolic disorders outcome [ Time Frame: between W0 & W48 ] [ Designated as safety issue: No ]
Enrollment: | 170 |
Study Start Date: | May 2007 |
Study Completion Date: | September 2008 |
Primary Completion Date: | September 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Intensification arm
emtricitabine/TDF + efavirenz or lopinavir/ritonavir + enfuvirtide
Drug: FTC/TDF + EFV or LPV/R +T20
emtricitabine 200mg/TDF 300mg (1 pill per day) + efavirenz 600mg (1 pill per day) or lopinavir/ritonavir (3 pills twice a day) + enfuvirtide 90mg twice a day
Active Comparator: Standard arm
emtricitabine/TDF + efavirenz or lopinavir/ritonavir
Drug: FTC/TDF + EFV or LPV/R
emtricitabine 200mg/TDF 300mg (1 pill per day) + efavirenz 600mg (1 pill per day) or lopinavir/ritonavir (3 pills twice a day)
Detailed Description:
In patients who have failed under the three main classes of antiretroviral agents (NRTI, NNRTI and PI) and in whom the control of viral replication in the plasma has ultimately been achieved with enfuvirtide, the aim is to sustain this virological success for as long as possible to thus enable satisfactory immune reconstitution, avoid further accumulation of viral mutations conferring resistance to the drugs and protect the patient from the risk of opportunistic disease and death.
Indeed, enfuvirtide is the lead compound in the new class of antiretroviral drugs which inhibit the fusion of HIV-1 virus with its target cell. Its in vivo efficacy was demonstrated during the pivotal studies TORO 1 and 2. Despite its efficacy, maintaining long-term treatment with enfuvirtide is nonetheless difficult for patients because of the constraints related to twice-daily subcutaneous parenteral injections. Furthermore, these subcutaneous injections are associated with inflammatory reactions at the injection site in 98 per cent of patients, without any reduction in frequency or severity over time. It is thus critical for patients who are well controlled by enfuvirtide to be able to simplify their treatment by replacing enfuvirtide with another active compound taken by mouth, which would enable maintenance of the virological response and acceptable safety in patients who have usually failed under the three main classes of antiretroviral drugs. A new antiviral compound, viral integrase inhibitor called raltegravir, could be proposed instead of enfuvirtide.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Chronic HIV-1 infection
- Treatment with a well-tolerated combination of antiretroviral drugs unchanged for at least 3 months, including enfuvirtide
- Absence of any uncontrolled opportunistic disease
- No restrictions on CD4 lymphocyte levels
- Plasma HIV-1 RNA below 400 copies per ml for at least 3 months (at least two consecutive tests below 400 copies per ml prior to inclusion in the study, not including that on W -4)
- For women of childbearing age, use of mechanical contraception during any sexual intercourse and negative pregnancy test (plasma ß HCG) at W -4
Exclusion Criteria:
- HIV-2 infection
- Plasma HIV-1 RNA levels above 400 copies/ml on one occasion during the 3 months prior to screening (or the pre-inclusion visit at W -4)
- Poor compliance with antiretroviral therapy current at W -4
- Current treatment with an investigational drug (except cohort ATU)
- Patient previously treated with an integrase inhibitor in the context of a clinical study
- Woman who is pregnant or likely to become so, is breastfeeding or refuses to use contraception
- Multiple drug therapy ongoing or necessary in the foreseeable future for Kaposi's disease or lymphoma
- Treatment with interferon ongoing or necessary in the foreseeable future for chronic hepatitis B or C
- Acute hepatitis whatever the case, or decompensated cirrhosis
- Current treatment with interferon, interleukin or anti-HIV vaccine
- Any condition (including, but not limited to, the consumption of alcohol or drugs) which might, in the investigator's opinion, compromise the safety of treatment and/or patient compliance with the protocol
- Significant biological abnormalities (hemoglobin below 8g per dl, polynuclear neutrophils below 750 per mm3, platelets below 50,000 per mm3, serum creatinine above 3 times the level deemed normal by the laboratory (N), ASAT or ALAT above 5N, serum lipase above 2N) and total bilirubin above 2N (except if the patient is receiving atazanavir or indinavir)
Concomitant treatments including one or more compounds interacting with UGT1A1
- anti-infective agents: rifampicin/rifampin
- psychotropic/anti-epileptic drugs: phenytoin, phenobarbital.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00454337
France | |
Service des maladies infectieuses et tropicales Hopital Saint Louis | |
Paris, France, 75010 |
Principal Investigator: | Nathalie De Castro, MD | AP-HP Hopital Saint Louis Paris | |
Principal Investigator: | Jean M Molina, MD | AP-HP Hopital saint Louis Paris | |
Study Chair: | Jean P Aboulker, MD | INSERM SC10 Villejuif France |
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) ( French National Agency for Research on AIDS and Viral Hepatitis ) |
ClinicalTrials.gov Identifier: | NCT00454337 History of Changes |
Other Study ID Numbers: | 2007-000162-20, ANRS 138 EASIER |
Study First Received: | March 29, 2007 |
Last Updated: | November 6, 2012 |
Health Authority: | France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis) |
Keywords provided by French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS):
HIV-1 infection enfuvirtide raltegravir treatment experienced |
Additional relevant MeSH terms:
Emtricitabine Enfuvirtide Lopinavir Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiviral Agents |
Enzyme Inhibitors HIV Fusion Inhibitors HIV Protease Inhibitors Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Protease Inhibitors Therapeutic Uses |
ClinicalTrials.gov processed this record on May 05, 2015


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I'll bet that SPAZZ is the first poster ...
The most difficult times for many of us are the ones we give ourselves. ― Pema Chödrön
Think of the haters in your life as sandpaper; theyll scratch you up time and time again but in the end youre polished, smooth, and spotless..while they end up useless
We make a living by what we get, but we make a life by what we give.
[This message edited by Jrazz at 12:54 PM, April 2nd (Tuesday)]

subset: commoncrawl


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Arizona Gov. Jan Brewer Vetoes 'Religious Freedom' Bill
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Some of the greatest TV characters in the history of television never appeared on the screen. Take a look at the some of the greatest TV characters you never saw.
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Posted May 03, 2013
Cowboy Bebop and Batman the animated series are what you are looking for
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This blog has moved… Posted on 15 August 2011 by Oud-medewerkers As I'm in the middle of switching jobs this blog has moved to bertertman.wordpress.com
Creating a dynamic locator service and client with WCF 4, WS–Discovery, your own standard endpoints and runtime meta data discovery Posted on 30 March 2011 by Oud-medewerkers Hello everyone, welcome to my third blog post. This time I am preparing for a WCF 4 training and in that training a very cool subject will be explained. Namely the new WCF 4 support for WS – Discovery. This Continue reading →
Final Post Posted on 22 December 2010 by Oud-medewerkers So this is my final post on the Info Support Blog Community site. As of January 1st of next year I no longer work for Info Support, so it doesn't really make sense to keep blogging here. I hope that Continue reading →
Async language support in C# 5 Posted on 29 October 2010 by Oud-medewerkers If you followed Eric Lippers blogpost on Continuation Passing Style programming last week you might have seen it coming: C# 5.0 will support a language integrated asynchronous programming model. No more hassle with IAsyncResults and delegates, no more need to Continue reading →
Windows Server 2008 R2 DVD image not recognised as known filesystem Posted on 26 November 2009 by Oud-medewerkers While installing Windows Server 2008 R2 for a customer as a Hyper-V guest on a Windows Server 2008 R2 Hyper-V host I ran into the following error: Load Driver: A required CD/DVD drive device driver is missing. If you have Continue reading →


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Rosemary Dr
Small garden bordering on a tidal stream. Across the road is a large pond which is part of the stream that comes from the Lake up the road. When it rains this pond fills up and spills into the stream causes the rushing water to pass at the bottom of our garden. There is a gazebo and a deck with four large Sago Palms, two big oak trees, a 'bottle brush' tree, two hibiscus in red and yellow and a rubber plant. There is a dipping pool and a covered patio. Around the garden is a fence with the back fence of black wire so that we can see the stream. The bar-b-que sits on the deck. There are two sheds for tools and pool equipment.
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Sorry again for the deafening silence. Lots going on and time is at a premium. I have a new (to Bull Runnings) first-hand account of the march to Manassas and the battle from a Marylander, courtesy of FOBR John Hennessy, and will try to get it posted tonight or over the weekend. Bear with me!
Good Account Coming
3 08 2012Actions
2 responses
- 3 08 2012
- 3 08 2012
Chris Evans
Looking forward to it.


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The RIB boat is doing 35 knots and Spinx is holding on as good as he can. He has been dreaming of seeing these large birds his whole life.
"What are the chances of seeing sea eagles today," asks Spinx."We are dealing with nature here, so I never promise my guests we will be lucky, but in the years I have done this, we have seen eagles on every single outing," says the captain.
Spinx smiles. Not only is he getting close to wild nature, he is going to see the wildlife up close. This is going to be his big story to take home to England.
Spinx travelled to the fishing village of Henningsvær where he joined a safari with Lofoten Opplevelser.
There are many other operators offering RIB boat trips and eagle safaris.
This is a good combination: You get to travel around the different islands while at the same time seeing the huge sea eagles at close range.
It doesn't take long until Spinx's eyes are wide open. The captain throws fish in the sea. The eagles follow him closely from up in the mountain wall. They wait. They know the fish are too big for the seagulls to swallow. We wait. We look. And then, finally. One of the eagles leaves its spot on the mountain wall and comes gliding towards us. It scares off the seagulls, aims for the fish and comes all the way down to the surface to pick it up with its sharp claws.
Spinx is stunned. Lost for words for a few seconds, before he shouts:
"Did you see that? Did you see that?"
I think we can say "yes". Everyone saw that.
The Lofoten Islands are known for the old fishermen's cabins ("rorbuer") that have been restored and turned into modern accommodation for travellers. Find a fishermen's cabin, hotel or campsite in the Lofoten Islands.
Explore the Lofoten Islands on foot, go rafting in the Trollfjord and visit Lofotr Viking Museum. Taste stockfish and be amazed by the midnight sun. Find out what to do in the Lofoten Islands.
There are daily flights into the three airports in the Lofoten Islands. Travelling around the Lofoten Islands is most easily done by car, bike and ferries. Find means of transportation to and in the Lofoten Islands.
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"Of all the things I get to experience, I think this is the big one," says Norway host David Spinx, out to meet sea eagles in the Lofoten Islands.
Eagle safari
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The access keys for this page are:
Last Updated: April 08, 2015
The physical address is 4500 Cherry Creek S Dr, Suite 200, Denver, CO 80246.
Child Health Plan Plus (CHP+) is low-cost health insurance for Colorado's uninsured children and pregnant women. CHP+ is public health insurance for children and pregnant women who earn too much to qualify for Medicaid, but cannot afford private health insurance.
You can download an application by clicking here.
Click a link below to see the CHP+ TV add.
As of February 2014, CHP+ enrollment is 56,540 children and 866 pregnant women.*
* Source: Joint Budget Committee Monthly Report.


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Stupid Activision always sucking X-Box's di@#, how come Sony never gets some packs first? Yes I know it's all done for exclusive and about money....still sucks....
Today is the day as the Zombie Nuketown map of Call of Duty Black Ops II has arrived. Here is the official word from Activision and Treyarch:
"The Nuketown Zombies Bonus Map is Now Available on the Xbox 360 Video Game and Entertainment System for Call of Duty: Black Ops II DLC Season Pass Holders
Today's the day Zombies fans! Call of Duty: Black Ops II Xbox 360 DLC Season Pass holders now have immediate access to the game's fan favorite Nuketown Zombies bonus map! Call of Duty: Black Ops II DLC Season Pass holders not only get four epic DLC Map Packs for the discounted suggested retail price of $49.99, but they also get the Nuketown Zombies bonus map - available for Xbox 360 today with other platforms to follow, plus an exclusive in-game calling card.
We hope you're enjoying the amount of gameplay packed into Call of Duty: Black Ops II. If you haven't done so already, grab the DLC Season Pass and take on Nuketown Zombies, and be sure to track your Zombies stats with Call of Duty Elite".
Stupid Activision always sucking X-Box's di@#, how come Sony never gets some packs first? Yes I know it's all done for exclusive and about money....still sucks....
Money talks man. Microsoft has got a little niche going with this exclusive thing and they've realized how much money they make from it.
They know people will still buy it so they keep doing whatever they want. If people start boycotting then you'll see things change quickly, but that'll never happen.
Xbox is the way to go that's why. I wouldn't bother with any other console. Hell with em. Ya get all the good stuff on Xbox.
mmm, let's not go crazy xJokersxWildx, I wouldn't trade my PS3 for anything (well...maybe a threesome with Salma Hayek and jennifer Love Hewitt but, what are the chances of THAT happening).
I think it would be fair for exclusives to go around and switch a little bit, not to stay with the same company forever. Get a 3 or 5 year deal then switch...a man can dream can he not???
I hate Xbox. Period. PS3 all the way. I can wait a bit. Besides. That is what I call my previous wife. The X-box.
I like the ps3 for their exclusives but im a xbox live guy for multi games. I feel people gravitate to it for a more competitve field. Im also going to say that party chat featurr gives a critical one up to xbox, when I can be playing one game and friends can be playing another game, it really creates a more social experience.
I am a PC player and I stand by the fact that console has killed video games...I love having my gameplay and graphics dumbed down for 7 year old obsolete systems with limited control capabilities.
i love pc gaming but for some reason i never really catches on with general public. I think a lot of it has to do with readiness of a console, no parent wants to shell out over 700 dollars for an overpriced dell and a lot of parents dont have a clue how to build a computer. I built my brother and my friends computers but they were still roughly 900 each, if you want a viable option you have to spend on parts.


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Who didn't love Larry Johnson when he played for the Charlotte Hornets? Rock this Caricature Crew sweatshirt from adidas. It features screen print graphics and soft fleece lining that will leave you comfortable while showing love to one of the NBA's greats.
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Article ID: 922819 - View products that this article applies to. Microsoft has released security bulletin MS06-064. The security bulletin contains all the relevant information about the security update. This information includes file manifest information and deployment options. To view the complete security bulletin, visit one of the following Microsoft Web sites:
PropertiesArticle ID: 922819 - Last Review: September 30, 2011 - Revision: 2.0 APPLIES TO


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Learn everything you need to know to get started building Android apps with the Android 5 SDK and Google's Android Studio IDE.
Move your app development process into Android Studio—the only IDE fully supported by Google for Android app development—with these tutorials.
Learn how to install and configure Apache, MySQL, and PHP, known collectively as the AMP stack, on a local development computer. These tutorials work with Windows, Mac OS X, and Linux systems.
Learn C#, the object-oriented language from Microsoft that's used to program systems, desktop applications, and mobile apps. These C# tutorials cover the history, syntax, and important concepts of this powerful programming language.
Explore solutions to common C# programming challenges, and compare the results with other programming languages, in the Code Clinic series.
Programming can be fun and gives kids a great head start. Teach your kids to program using these learning techniques, apps, and hardware.
Teaches Android developers how to program with the Fragments API, and build apps that work well on Android phones, tablets, and even desktop computers.
Get a first look at Android Studio, the new IDE for building and packaging Android apps, before its official release.
Learn to request data for your Android apps from cloud-based storage networks that offer RESTful web services.
Take a tour of the new features in Java SE 8, including lambda expressions, the Stream and DateTime APIs, and Nashorn.
Protect your sites—and your servers—from Heartbleed. Learn how to audit, test, and fix vulnerability issues associated with OpenSSL.
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Create a complete mobile app from scratch with the Android SDK and Java in this project-based course.
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Describes how to read and manage data from relational databases such as MySQL and SQL Server using the Java Database Connectivity (JDBC) API in applications programmed with Java.
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Explores Java SE, the language used to build mobile apps for Android devices, enterprise server applications, and more.
Offers developers an overview of the latest enhancements found in Flash Builder 4.5 and Flex 4.5.
Reviews the dozens of new features added to the Flex 4 SDK and Flash Builder 4 toolset, explaining critical information for building rich internet applications.
Explores the newest release of the Flex SDK and Flash Builder, explaining critical information for building rich internet applications.
Explains the configuration and implementation of a ColdFusion 9 environment, including everything necessary for full implementation of ColdFusion in a web development.
Adobe Certified Instructor David Gassner brings AJAX developers deeper into the functions and features of AIR 1.5 used with Dreamweaver CS4.
Demonstrates the installation of Apache, MySQL, and PHP for Mac OS X and Windows.
Demonstrates advanced techniques in ColdFusion 8, such as creating multimedia presentations and working with XML files.
Teaches the essentials of internet application development using ColdFusion 8.
Demonstrates how to use Dreamweaver CS3 to create professional, data-driven, interactive web sites.
Covers everything from the new scripting image tags to the extended image and PDF capabilities in ColdFusion 8.
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text: WJACTV -- On Dec. 1 it was announced that the Department of Environmental Protection in Pennsylvania would be offering grants to businesses interested in purchasing or converting vehicles to use compressed natural gas (CNG) or liquified natural gas (LNG). Through Act 13's impact fee, a new three year Natural Gas Energy Development plan was made available through the DEP. Over the next three years, this new program will make $20 million in grant funds available for businesses to purchase or convert vehicles. According to the DEP, the money will be allocated on a fiscal year basis. During the 2012-2013 period, $10 million will be awarded. Officials said $5 million will be available for local transportation agencies. Officials said during 2013-2014, $7.5 million will be awarded. Fifty percent Read the Full Article


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I had three winter babies and the first one, my January girl, she was the skinniest. I loved her little chicken legs but my, were they scrawny. They were scrawny, so scrawny, until the day they weren't, which I didn't quite realize until a stranger pointed it out while I had her splayed in the most graceful of positions, mid-poop wipe on a drop-down changing table in a public restroom of a club warehouse store. "My, those are some ham hocks!!" exclaimed a woman's southern drawl over my shoulder. It took me a few moments just to comprehend that she was speaking to me, let alone about my baby.
"Um, what?" I said hesitantly, unsure I wanted to engage in the potential of any conversation whose opener involved pig parts as analogy.
"Your baby's legs! Those are some ham! hocks! So juicy you could just take a bite out of them! Well, I mean after you finish wiping her up. Ha ha! My kids all had ham hock thighs, too. Ain't she just delicious!" And then the woman disappeared into a stall.
She was right, though. My skinny baby had perfect ham hock thighs, I realized, immediately after wandering through the meat department to discover what a ham hock was.
That was my first Easter as a mother.
We didn't think E would eat matzah at all this Passover, so contracted is her palate and her list of Acceptable Foods. But she has surprised us once again. She will eat matzah with cream cheese, and she will eat matzah with butter. But she wants it spread on both sides. Imagine a fragile 10" square cracker and the picky-eater preschooler who will agree to eat food, if only you get that cracker spread thickly on both sides. Without any breakage, of course. It has taken me all these years to understand the phrase "the bread of affliction" fully, I now believe.
I diapered G a few days ago, just after we arrived to my parents' house, and I realized that Easter is here. For lo, my skinny February baby, he has entered the season of ham hock thighs. And the warehouse club bathroom lady was right: they are juicy. And they are delicious. (After they're all wiped clean.)
Happy applicable holiday, friends.


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Jack Nicklaus Napa Valley Cabernet Sauvignon
Big & Bold
Jack Nicklaus Napa Valley Cabernet Sauvignon 6022WZBNow Only $54.99The price of wine includes shipping!
Golf legend Jack Nicklaus has lived his entire life in pursuit of excellence, whether mastering the game of golf and designing some of the most challenging and distinctive golf courses around the world. His signature Napa Valley Wines present the same level of excellence. The color of this Cabernet Sauvignon is a beautiful garnet. On the nose is red plum and blackberry with notes of cedar. On the palate intense and layered with mocha, red currant and sweet spices, concentrated mid-palate with a lingering finish.
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There are many types of skin, varieties of skin concerns and a host of dangers and aggressors that can affect the health and appearance of skin. The developers of DermaQuest Skin Therapy Therapeutic Care have formulated an expansive range of products which address a broad spectrum of the most-needed preparations. The "quest" in DermaQuest Skin Therapy Therapeutic Care is to serve you in overcoming the wide range of challenges you face in skin care and skin health.
When skin is assaulted by airborne pollutants, the sun's harsh UV rays, wind and temperature fluctuations, DermaQuest Skin Therapy Therapeutic Care is there with products to repair, regenerate and protect skin. Both young and aging skin require constant attention to hydration, particularly in maintaining the balance of moisture in the skin. Addressing collagen health, the DermaQuest Skin Therapy Therapeutic Care line of products not only help keep skin moist and supple, but help reduce the appearance of fine lines and wrinkles. Promoting and maintaining elastin production keeps skin firm and young-looking, while attention to causes of melanin overproduction can help with problems related to hyperpigmentation.
Since skin cleansing is the first and, in many ways, most important step in skin care, DermaQuest Skin Therapy Therapeutic Care provides an excellent cleansing product.
DermaQuest Skin Therapy Daily Enzyme Cleanser, effectively removes dead skin cells, excess oils and the dirt and pollution deposited by the environment, but without stripping off the naturally protective oils on the skin. It includes breakthrough ingredients, including bromelain (an enzyme from pineapple) and papain (from papaya fruit), which cleanse, exfoliate and lighten the skin. Properly hydrated skin is vital to a smooth, healthy texture and a firm skin tone. The collagen-boosting and protecting ingredients in DermaQuest Skin Therapy Revive Cream are also paired with hydrolyzed elastin to keep your skin firm and youthful in appearance.
A broad, but carefully selected and balanced suite of effective botanical oils and extracts are featured in DermaQuest Skin Therapy Antioxidant Soothing Serum. Not only do these botanicals fight free radicals but, combined with the copper compound ingredient, help calm, repair and rebalance damaged skin.
The sun's UV rays can be brutally damaging to skin, but it seems almost impossible to completely avoid them. With the protection of DermaQuest Skin Therapy Solar Moisturizer SPF 30, it isn't necessary to hide in the dark. This is more than just a sunscreen; although it has ingredients which are included primarily to screen UV rays, there is also a suite of effective botanical extracts, sources of vitamins C and E, natural sodium hyaluronate and idebenone to stimulate collagen production, firm and tighten skin, balance moisture and prevent collagen breakdown.


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Thos. Moser Cabinetmakers, designers and builders of fine furniture since 1972, based in Maine with retail showrooms located across the USA.
Welcome to the Thos. Moser blog. Here you'll find stories, news, and other happenings about our company and furniture design. Please post your comments and send us an email with suggestions.
Current Articles | RSS Feed


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Cart (0) Account Newsletter Contact
866-539-4278866-539-4278 - Shipping - FAQ
What's more classic than the marketing images of America's favorite soda pop, Coca-Cola Co. A vital part of our Americana puzzles collection, these Coke brand puzzles have been ever popular around the holidays for gifts and for special collectors that love to display this iconic label as decoration.
Use the filters to the left or simply scroll down to begin viewing all pages.
Free shipping and flat rate offers for US only but excludes HI and AK.
Need to return or exchange a puzzle? It's easy. Simply call us at 866-539-4278 or email email@example.com to request a Return Authorization Number, and we will send you a prepaid return label for the item.
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IMO, a developer shouldn't become a "fanboi" of a language. The language shouldn't matter at all; pick the most appropriate one for a given project.
Unfortunately, many people seem to believe that "the best choice" is always C and have become quite obsessed with it. That shouldn't happen. Perhaps it's because C is all they know and try to hide that fact.


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More than 30 allegedly maltreated horses seized by Utah law enforcement authorities will be sold at auction to recover costs connected to their care.
To continue reading this article, become a member of TheHorse.com.
It's FREE and you'll get full access to more than 20,000 articles, video, free reports & more.


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GRAMMY-winning recording engineer Ryan Hewitt explains his techniques for capturing drum sounds. "Drum Doctor" Ross Garfield consults with Ryan on a real-world studio setup for a session with A-list drummer Josh Freese.
JK "saintjoe" Swopes—educator behind MaschineTutorials.com—shows how to get started creating your own beats, hooks, and harmonies with Maschine.
Larry Crane, critically acclaimed record producer and founder of Tape Op magazine, describes his self-taught, largely trial-and-error path to success in the music industry.
Takes you over the Logic Pro learning curve, showing how to compose, record, edit, and mix great sounding music.
Take control of every step of the audio production process and start making great sounding music in this fast-paced SONAR X2 tutorial.
Introduces AmpliTube, a studio-quality app for playing guitar and bass through the iPad and recording a collection of classic and modern guitar sounds.
Record great-sounding music with Auria, the first major digital audio workstation designed specifically for the iPad.
Create music in real time, on stage, or while producing in the studio, with Ableton Live.
Discover how to get started creating and recording music with Ableton Live 9 in just two hours.
Get a jumpstart on Reason, the virtual music studio used by some of the world's most popular musicians and DJs.
Shows nonaudio professionals how to set up Audacity, a free audio editor and recorder for Windows, Mac OS X, and Linux, and start recording live audio.
Discover the industry secrets to recording crisp, rich vocals and instruments tracks, as renowned audio engineer Bobby Owsinski walks through the process of miking and tracking a complete song by Underground Sun recording artist Iyeoka and A-list session musicians in a top-of-the-line studio in a way that is applicable to any recording space and musical genre.
"Keep up the good work—it's helping so many of us stay up to speed on all the many topics involved in building creative websites." —Sandra M.
more from our members »


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Top Definition
After taking a shit, you don't not manage to wipe all shit residue. Then later in the day, while doing an activity that causes you to sweat... your left over shit residue and sweat combine, leaving you with swap ass. It itches and smells terrible. Bascically it becomes itchy ass butt sweat.
While playing basketball, Richard felt an errie feeling of swap ass, his left over shit residue combined with sweat. He had to leave immeadiately to take care of his situation.
dezstbbinn tarafından
12 Mart 2009, Perşembe
2 more definitions
A wet sensation in your underpants from sweaty buttocks.
That fart gave me swapass!
hot thud tarafından
18 Ekim 2006, Çarşamba
a girl that looks like shit
Look at that swap ass!
JerDunc aka J-Bird tarafından
10 Ekim 2006, Salı


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Anyone Can Do Usability
Jakob Nielsen posted an interesting article on expanding the reach of good usability:
Summary: Usability is like cooking: everybody needs the results, anybody can do it reasonably well with a bit of training, and yet it takes a master to produce a gourmet outcome.
One of the discount usability movement's basic tenets is that we need a drastic expansion in the amount of usability work done in the world, and to make this happen we need more people to take on usability assignments.
Read the rest here.
Add new comment
December 30, 2009
User Experience, Human Computer Interacion, User Interface are all concepts that interest me. I feel like I'm always filled with ideas to make businesses, people, and applications better. I don't have a programming background but I do have experience and passions that would contribute to the UI/UX/HCI skillset. You say we need more people to take on usability assignments. How do I get involved? Do you need a masters to do this stuff?


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Starlight Family Storytime | |
Event Type: Storytimes Age Group(s): children with an adult, all ages, all ages Date: 12/10/2013 Start Time: 6:30 PM End Time: 7:15 PM Description: Bring the whole family for an evening of storytime fun. We'll read, move, and rhyme with a different theme each week. Nurture a love of reading through books, music, and activities. Almost bedtime? Feel free to wear your pajamas!
Library: Thurmont Regional LibraryLocation: TRL Community Room Contact: Marlene Bordner Contact Number: 301 600 7214 Presenter: Marlene Bordner |


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Redeem when you want, for what you want.
Reward Nights When redeeming points for a Reward Night, you may only book one room at a time. Once you complete your Reward Night reservation you will be given the option to duplicate this reservation
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** Best Available Rate Search does not include affiliation rates.
To book more than 9 rooms for one stay or request a quote, please use our Easy Meetings tool, call 1-800-MEETING (in United States, Mexico and Canada) or contact a Global Sales Office.
Located just off of I-10 and minutes from Lafayette, the heart of Cajun Country and the area's best attractions, our Breaux Bridge hotel's location is perfect for business and leisure travelers alike. When you are traveling from Orlando, Houston or Phoenix, make sure you "Stay Smart" at our hotel, which features great amenities and outstanding service.
We are one of the best Breaux Bridge hotels because we're close to area attractions. View More
We are one of the best Breaux Bridge hotels because we're close to area attractions. Situated near the Crawfish Festival grounds, Atchafalaya Basin Swamp tours, authentic Cajun music, dining and dancing, our hotel is in the middle of it all. Enjoy lively concerts at Cajundome or explore world-class fishing and hunting areas nearby.
Corporate guests love our Breaux Bridge hotel's location because we are minutes from the Prehistoric Park. The Tabasco plant in Avery and local businesses are nearby in Breaux Bridge. Lodging here means you can enjoy the convenience of a Business Center, free high-speed Internet access and copy and fax services at our front desk, as well.
If you are looking for hotels near the Lafayette area and I-10, our Breaux Bridge hotel's amenities provide you with everything you need, including a sparkling outdoor pool, a well-equipped Fitness Center and a hot breakfast bar to start your day off right. Choose from one of our 58 newly renovated rooms and make your reservations today for the best in Breaux Bridge lodging.


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Neck-and-neck with A's, Angels head to Fenway
Halos send Wilson vs. Workman, Red Sox
Angels left-hander C.J. Wilson snapped a string of five winless starts when he beat the Phillies, 7-2, last week at Angel Stadium of Anaheim.
He also might have figured out how to bust out of the slump that's plagued his 2014 season.
"I just think that if I stay with my eyes on the target the whole way, then the ball's going to go where I want it to go," Wilson said after allowing two runs over 6 2/3 innings. "And if the ball goes where I want it to go, then it's going to be good. Because I know exactly what my stuff does. It's just a matter of trying to keep it where I want."
Wilson (9-8, 4.71 ERA) will get a chance to test his theory Monday when he gets the start against the Red Sox in the opener of a four-game series at Fenway Park.
The Angels were three outs away from a six-game winning streak Sunday, but closer Huston Street blew a ninth-inning lead in a 3-2 loss to the Rangers, which dropped Anaheim to 72-50 and tied with Oakland atop the American League West.
Boston will counter with Brandon Workman (1-6, 4.45 ERA), who will be working on extended rest after the club skipped his last start in the rotation.
Fatigue was cited as the reason, but it also likely had something to do with Workman's recent struggles. He's been tagged with the loss in each of his last six appearances (five starts), while posting a 6.35 ERA over 28 1/3 innings.
Workman hasn't appeared in a game since giving up a walk-off home run to Albert Pujols in the 19th inning of a 5-4 loss to the Angels on Aug. 9.
Red Sox: Craig to begin rehab assignment
Outfielder Allen Craig will begin a rehab assignment with Triple-A Pawtucket on Monday.
After being dealt from St. Louis to Boston on the July 31 non-waiver Trade Deadline, Craig sprained his left foot stepping on first base during his first game with Boston.
His impending return could mean less playing time for Daniel Nava, who has been swinging the bat well after a tough start. He was optioned twice, but since coming back on June 5, entered Sunday with a .331/.399/.393 slash line.
"He's playing with a lot of confidence right now, and that's because of the consistency of the at bats," manager John Farrell said. "I looked up [Saturday] night to see where the average is, and it's more than double from the time he was sent out. It's a testament to his work ethic and the quality hitter that he is, particularly left handed."
Nava is a switch-hitter, but typically plays against right-handed throwers because he platoons well from the left side of the plate. He can play left field, too, but newly acquired left fielder Yoenis Cespedes mans that spot.
So what's the plan for Nava?
"For as well as he's swinging the bat, we're going to find a way to get him in the lineup," Farrell said. "Much like with Brock Holt earlier, we'll find a way to accommodate all this."
Angels: Hamilton sits
Struggling outfielder Josh Hamilton wasn't in the starting lineup Sunday after combining to strike out seven times the previous two games.
"Just give him a little refresher; give him just a mental break, let him exhale a little bit," manager Mike Scioscia said. "This guy's working really hard trying to find it. We have to get him back to where we need him. Sometimes just exhaling is something that can help him. We've seen the struggles recently, and today is just a good day."
Hamilton is hitting just .189 (10-for-53) in August. The slump has dropped his season average to .266. Scioscia declined to say if the outfielder will continue to hit cleanup when he returns to the lineup.
"He's just not playing with the same confidence that he's had," Scioscia said. "I don't know if he's as confident in the box as he needs to be, and that's where we need him to get."
Worth noting
• Red Sox second baseman Dustin Pedroia, who turned 31 on Sunday, missed the 8-1 loss to the Astros with flu-like symptoms.
• The Angels have won six of their last eight games at Fenway and have scored five or more runs in seven of their last eight contests in Boston. They've also won 12 of their last 17 games overall against the Red Sox.
Adam Lewis is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Kraus KPF-2150 Stainless Steel Stainless Steel Pullout Spray Kitchen Faucet
Kraus Stainless Steel Sale: Prices already marked down up to 60%
Save an additional 5% at checkout with coupon code KrausFive
Offer Ends 5/14/2015
Technical Specs
Spec / Installation Sheet | |
ADA | Yes |
Eco Friendly | No |
Escutcheon Included | No |
Faucet Centers | 0 |
Faucet Holes | 1 |
Faucet Type | Kitchen Faucet |
Filtering | No |
Flow Rate (GPM) | 2.2 |
Handle Material | Metal |
Handle Style | Lever |
Handles Included | Yes |
Height | 16.34 |
Installation Type | Deck Mounted |
Low Lead Compliant | Yes |
Material | Stainless Steel |
Max Deck Thickness | 3 |
Number Of Handles | 1 |
Pre Rinse | No |
Product Weight | 9 |
Pullout Direction | Down |
Pullout Spray | Yes |
Sidespray | No |
Soap Dispenser Included | No |
Spout Height | 8.27 |
Spout Reach | 10.04 |
Spout Swivel | 360 |
Spout Type | Swivel |
Theme | Traditional |
UPC Approved | Yes |
Valve Type | Ceramic Disc |
Product Features:
- Fully covered under Kraus' limited lifetime warranty
- 100% Stainless steel faucet body and handle construction
- High-quality, corrosion and rust resistant finish - finish covered under lifetime warranty
- Insulated pullout spray faucet head with 24" hose
- Spout swivels 360 degrees to allow for unobstructed sink access
- Two settings: spray and stream
- High-arch gooseneck spout further allows for unobstructed sink access
Product Technologies and Benefits:
- Precision Kerox Cartridges: The cartridge's job is to deliver smooth handle operation and water flow, throughout hundreds of thousands of uses, without ever leaking – all while under a punishing 60 pounds-per-square-inch of pressure. For these reasons, it is quite literally what "makes or breaks" the faucet. Kraus understands this, so they take no shortcuts here, importing their cartridges from the world's leading manufacturer of high-end precision ceramic disc cartridges, Kerox in Hungary.
- Swiss-Made NeoPerl Aerators: Aerators are possibly the most under-appreciated component within faucets. Not only do they soften the stream (preventing splashing), but they also control the straightness, diameter, overall delivery of water. Fortunately, like their cartridges, Kraus recognizes this and chooses to takes no gambles here – they import their aerators from NeoPerl in Switzerland, the world's leading manufacturer for high-end and specialty aerators.
- Heavily Certified: Kraus has gone to great lengths to be able to provide you, the homeowner, the rest-easy satisfaction knowing that your faucet is certified and listed by all the major product testing boards in the U.S. and Canada. This means that this faucet is deemed safe to use and that it meets all applicable building codes. Certifications and listings include: UPC, cUPC, CSA, IAPMO, ANSI and SCC.
Product Specifications:
- Overall Height: 16-1/3" (measured from counter top to highest point of faucet)
- Spout Height: 8-1/4" (measured from counter top to faucet outlet)
- Spout Reach: 10" (measured from center of faucet base to center of faucet outlet)
- Number of installation holes required: 1
- 2.2 gallons-per-minute flow rate
- Installs onto decks up to 3" thick
- 1 handle included
- ADA compliant
- Low lead compliant - complies with federal and state regulations for lead content
- Designed to easily connect to standard U.S. plumbing supply bibs
- Extra secure mounting assembly
- All necessary mounting hardware included
Special Note
This kitchen faucet is available as a kitchen combo with a number of sink choices. Like their faucets, Kraus kitchen sinks have gained tremendous momentum within the kitchen and bath industry and are highly regarded for their quality, durability, and meaningful innovation. If you are considering a purchase of this faucet and also need a new sink, we urge you to consider the kitchen combos; they truly are a deal. To the right of these product details you will find 5 kitchen combos that include this faucet. All kitchen combos that use this faucet can be found by typing "KPF-2150 combos" into the search bar at the top right of this page.
Special Sale (limited time only):
- Save 5% on Kraus kitchen sinks and faucets with coupon: KRAUSFIVE
Additional Kraus Links
- View Manufacturer Warranty
- Shop All Kraus Products
- Shop All Kraus Kitchen Faucets Collection Products
Our SKU: KPF-2150
This product is listed under the following manufacturer number(s):
- Stainless Steel
*Denotes a finish or option that has been discontinued
2 Questions from the Community
The Kraus KPF-2150 does not have an exact measurement given on their spec sheet but typically you are going to want about 2-3 inches behind the base.
How much space (counter length) between the sink and the backsplash is needed to install this faucet properly and allow full clearance for the handle?
A. The Kraus KPF-2150 does not have an exact measurement given on their spec sheet but typically you are going to want about 2-3 inches behind the base.
The maximum deck thickness for the Kraus KPF-2150 is 2". The KPF-2230 is 1.5" thick.
What is the maximum deck thickness?
The maximum deck thickness for the Kraus KPF-2150 is 2". The KPF-2230 is 1.5" thick.
Product Reviews
Kraus Kitchen Faucets Collection
Other Products In The Kraus Kitchen Faucets Collection
Kraus KPF-2230
Pullout Spray Kitchen Faucet$138.99-$179.95(82)
Kraus KPF-1602
Commercial Style Pre-Rinse Kitchen Faucet with Pot Filler$249.95-$297.95(101)
Kraus KPF-1612
Commercial Style Pre-Rinse Kitchen Faucet$149.95-$169.95(64)
Kraus KPF-1602-KSD-30
Commercial Style Pot Filler Kitchen Faucet with Pr...$269.95-$322.95(29)
Kraus KPF-2230-KSD-30
Pullout Spray Kitchen Faucet with Soap Dispenser$159.95-$179.95(30)


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Chicago White Sox Gear
Chicago White Sox Kids
Vintage Clothing
(11 items)
Product ID: 1112686
Main Content
Your girl may not be the rough-and-tumble type, but she loves her White Sox! In fact, in her opinion, there could be no greater pairing than the Chicago White Sox and sparkles! This printed Love T-shirt is just right for the girl who likes to dress up her Sox enthusiasm. The front of this tee features printed team name and "Love" lettering, the Chicago logo and a painted style print with sequins. Your young lady is sure to shine bright with White Sox pride in this lovely shirt.
- 100% Cotton
- Imported
- Officially licensed MLB product
- Quality screen print graphics
- Sequins in lettering
- Tag on collar
Special event items are produced by manufacturers only after the outcome of a game
or event. These are advanced sale items and will ship immediately after they are
received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items
are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite
number, and/or designs. Some options may be limited by league rules.


text:
The original deal pioneer keeps on pinching pennies and cracking wise. No, that price isn't a typo.
Go to Woot
Candlepower and puppet shows are so passé. Get the newest TVs, speakers, home theater gear, and more.
Go to Electronics.Woot
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Go to Computers.Woot
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Go to Home.Woot
Make it, build it, improve it. But whatever home project you've got in mind, start by saving money on it.
Go to Tools & Garden
Sports, fitness, and outdoors deals, because saving money is only one of your passions.
Go to Sport.Woot
You don't have to spend a lot to look like you do. Werk it and twerk it with amazing deals on designer watches, handbags and more.
Go to Accessories & Watches
Deals for moms and dads and anybody else who needs kids' stuff, from toys to baby gear to furniture to clothing.
Go to Kids.Woot
Our exclusive graphic tees will make you laugh, will make you cry, will make you look totally hot.
Go to Shirt.Woot
Direct from the winery to your thirsty lips: wine deals worth doing a spit-take over.
Go to Wine.Woot
Last chance deals for hardcore cheapskates. Catch 'em before they - you guessed it - sell out.
Go to Sellout.Woot
460,320 deals (and counting) from around the web, shared and ranked by a community of deal fiends like you. Go to Deals.Woot.
Re: Origami attack
Extremely cool. Would love to see an origami swan flying around in there somewhere though.
Re: Like a Lumbering Leaf on the Wind
Cracked me up! GMV
Re: Escape
Love the colours. Adorable. I want one.
My first time, please be gentle.
Re: I can't! It's so adorable
Alf! I almost shouted. Nice idea.
ladynigelia wrote:While I love this scene, I don't find this to be obviously petunias enough to be a successful shirt.
I appreciate the feedback. The original version of this design had an adorable whale falling from the sky and the petunias were much more defined. After 6 hours of work, Photoshop crashed and ate my file. It was completely corrupted and irretrievable. Resisting the urge to cry and quit drawing forever, I made this one in haste. Now I'm double sad that my original design is lost. It was much, much better.
Re: Meowtropolis
Hee. Nice but feels a little generic. If one of the kitties was clearly robotic a la Maria...
Re: Inevitable Betrayal
Much better with the added details. This should go without saying, but GMV!
I very rarely comment on shirts but I have to. I love this one and can't wait to buy it.
Too Soon? GMV
i really would never wear a pokemon shirt, but i wish i would so i could have this one! its amazing.
Re: I'm a freaking Jedi!
You're a freaking genius. Love it!
Re: Are You Han Enough...
If you give a Wookie a Cookie...
This is absolutely awesome, I love it.
Re: A storm is coming
I see it as a Star Wars/Guardians of Ga'hoole mash-up.
Awesome! I love it. I definitely would wear this with - pride...
jasneko wrote:Sci-fi references in here, but I think it works (and tried to make it so) without the references as well. They're just a bonus if you like them.
I NEED this shirt!!! This is completely AWESOME!!! Great job!
I adore you for creating a Metropolis shirt!!! Win!!!
TobiasAmaranth wrote: And, as a bit of an anti-Ramy person around here... I admit I at least laughed at this one. It's certainly stretching the derby a bit, but it does count. I voted for once.
Totally agree, usually not a fan of some of his stuff, but I think recently it's got a lot better, and this is probably my favourite shirt I've seen him do... Fantastic work, definitely gets a vote (and a half).
teasel49 wrote:Starship Troopers, a great, bad movie. Everyone else is doing their part, what about you?
Wow, I actually got this reference. Pretty good considering it's a movie I haven't seen.
Re: Can I Keep It?
Playing off the concept of alien abduction. Last week, my wife brought home a kitten. I was wondering how that played out when an alien gets home with his new "pet." Enjoy!
Re: How to make an electric mouse
Excellent! Hahahahaha
Re: My Friend Doesn't Like Ewe
My 3rd entry in a Woot Derby. Who doesn't find sheep jokes funny?
The art is well done, but yeah....I really don't understand why this is in the fog. O.o
thumperchick wrote:I think without the bowler hat, it doesn't come across as obviously from Clockwork Orange. If the brim of the hat were added I think it would come across cleaner - it would also get a +1 from me - I love the idea of adding ultracute to ultraviolence.
Thank you for the suggestion!!
Re: Unidentified Flying Penguin
Cute... but man are penguins old now. So many penguin woot shirts!
toby8915 wrote:Even the communicator knows the red shirt isn't making it back to the ship.
Wow great idea! Really creative. Made me laugh.
Re: Woodland Exterminators
I need this to be printed so I can have the most awesome shirt ever.
Re: Wrong Droid
I love this shirt so much and really hope it prints. I could take or leave the text, works both ways.
Re: Por-tail
Not that I'm accusing anybody of taking ideas, considering that folks have similar ideas on a regular basis here on Woot but I did a very similar design in a previous derby: http://shirt.woot.com/Derby/Entry.aspx?id=56249
Re: Indaiana Monster and the Last Cookie
Re: Roswell autopsy
Hahaha... Brilliant!
This one is really Great!
fventz wrote:Awesome design. Please resub SOON with shirt template and placement.
sure bro!
Another +1 from me, and hopefully another -1 to my wallet.
Re: Ninjas in space (with dinosaurs)
This is gorgeous and deserves more attention. Great work!
Re: Push the button, Luke!
Two of my favorite SciFi shows mashed together
So cool!
nice design dude
View All →


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Jump to navigation
The Asia-Pacific region is becoming a significant driver of global economic growth. In 2010, the region's developing countries grew at a rate of 8.8 per cent compared to 2.7 per cent for the world's developed economies. In the region, mobile telephony and broadband internet in particular are bringing unprecedented digital opportunities that are transforming societies. However, a number of gaps, particularly in infrastructure, need to be addressed to ensure that these digital opportunities do not engender a digital divide, thereby accelerating regional inequities.
High food prices have put increasing inflationary pressures across the Asia-Pacific region and threatened food security. Bad weather in important food-producing countries and speculation in commodity markets have affected global food supplies and added volatility to booming commodity markets that have been fueled in the long-term by increasing global demand. High food prices have threatened to slowdown economic growth, poverty reduction and inclusive sustainable development throughout the region.
Asia-Pacific MDGs reports have been produced since 2004 by the Economic and Social Commission for Asia and the Pacific / Asian Development Bank / United Nations Development Programme regional partnership to support the achievements of the MDGs.
There is ample evidence that successful implementation of bilateral or regional trade and economic integration initiatives would have a very significant impact on intraregional trade in Asia and the Pacific. However, little is known about the level of intraregional trade costs in the region and to what extent these costs may have decreased over time. This paper introduces new aggregate and sectoral estimates of bilateral trade costs in Asia and the Pacific available in an updated and extended version of the ESCAP Trade Cost Database (Version 2).
The Single Window Planning and Implementation Guide contains managerial guidelines for policy managers, policymakers and those who are tasked to plan and manage the information technology-enabled Single Window development projects for simplifying cross-border trade procedures and document requirements within developing economies and transition economies.
The Low Carbon Green Growth Roadmap for Asia and the Pacific explores the opportunities that a low carbon green growth path offers to the region. It articulates five tracks on which to drive the economic system change necessary to pursue low carbon green growth as a new economic development path.
While efforts to mitigate climate change continues by reducing greenhouse gases (ghg), the impacts of climate change has resulted in changes to the hydro-meteorological events of floods and droughts, translated in more extreme case of events. Climate Change has also increase the melting of the polar ice and the water towers of the himalaya's hindu Kush, and threaten coastal settlements with sea-level rise. all this will have significant impact on
While regional countries are driving the global "green growth" agenda, policymakers are facing a new economic reality and heightened uncertainty. The challenge of eco-efficient economic growth and inclusive resource use is critical and growing in several countries. Fundamental, rather than incremental changes are needed - Governments must therefore take the lead in re-orienting both the "visible" and the "invisible" economic infrastructure. At the same time the implications of heightened uncertainty and risk for policymaking requires more attention.
Fifty one case studies and eight policy papers that were developed as associated products of ESCAP's Low Carbon Green Growth Roadmap for the Asia and the Pacific. The Roadmap may be accessed from this link: http://www.unescap.org/resources/low-carbon-green-growth-roadmap-asia-an....
Managing climate change caused by greenhouse gas (GHG) emissions has been recognized as one of the world's greatest challenges in current times, in particular in Asia and the Pacific which accounts for most of the world's GHG emissions. Without urgent action to curb such emissions, climate change will be more severe resulting in larger global temperature rises.
The United Nations Building Rajadamnern Nok Avenue Bangkok 10200 Thailand
Telephone: (66-2) 288-1234
Fax: (66-2) 288-1000


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Crew aims to get back on track against Cubs
Milwaukee's Lohse squares off against Chicago's Rusin at Wrigley Field
As their up-and-down season continues, the Brewers will visit Wrigley Field on Friday, with the hopes of snapping out of a recent funk and, in turn, staying out of the National League Central cellar.
After winning back-to-back series against NL Central powers Cincinnati and Pittsburgh from Aug. 23-29, the Brewers have stumbled in their two series since. They suffered a sweep at the hands of the Angels last weekend and, though they won Wednesday, dropped a three-game set to the Pirates.
The Cubs, meanwhile, enter the three-game weekend set having salvaged Wednesday's series finale with a comeback victory to avoid being swept by the Marlins. On Friday, Chicago will call on young lefty Chris Rusin, who turned in a solid month of August in spite of his 1-3 record.
Rusin tallied just one win in six August starts despite limiting the opposition to two or fewer earned runs in all but one of those outings. He finished the month with a 2.64 ERA and is 2-3 with a 2.74 ERA in nine starts overall this season, which comes after struggling to a 6.37 mark in seven starts last season following his big league debut.
"He was here last year and had some struggles, but [he] understood, 'This is what I have to do to get big league hitters out,'" Cubs manager Dale Sveum said. "He's been able to do that. I think the biggest thing for him maturity-wise is making the pitches when he has to make them. That's been the difference."
Milwaukee will counter with veteran Kyle Lohse, who rebounded well on Sunday after serving up a career-worst 13 hits in his previous outing. After being tagged for five runs off those 13 hits over just 5 1/3 innings on Aug. 27 against the Bucs, Lohse limited the Halos to just one run off seven hits over six innings of work on Sunday.
The 34-year-old righty, who was drafted by the Cubs in 1996, received no-decisions in each of those outings and sits at 9-8 with a 3.32 ERA in 28 starts this season.
Brewers: Segura expected back Friday
All-Star shortstop Jean Segura was held out of Wednesday's starting lineup because he was sick, manager Ron Roenicke said, but is expected to return Friday.
• Milwaukee starters have turned in quality starts in six of their last seven games, going 2-2 with a 3.00 ERA.
Cubs: Division games proving difficult
Starting with Friday's series opener against the Brewers, the Cubs will play 20 of their final 23 games against NL Central opponents. It's a slate that seemingly does not bode well for Chicago, considering the Cubs have posted just a 19-37 record against the Central this year.
The 19 wins are the fewest victories for any club within its own division. Over their final 23 games, the Cubs will play seven each against the Brewers and Pirates, three each against the Reds and Cardinals and three more against the Braves in their lone remaining non-divisional series.
"So many people put emphasis on what division, and whatever," Sveum said. "We're trying to win any game. It doesn't matter who we're playing. We're going to be playing some contending teams, but for the most part, right now the playoffs are finalized in the National League, unless somebody goes out and loses every ballgame they play."
• The Cubs claimed former first-round Draft pick Daniel Bard off waivers from the Red Sox on Wednesday. Cole Gillaspie was designated for assignment to make room on the 40-man roster for Bard, who will join the Cubs on Friday.
Worth noting
• Segura is looking to become the second player in franchise history to lead his league in stolen bases (Scott Podsednik, 2004). With 39, he has a two-steal lead over suspended Padres shortstop Everth Cabrera and four more than Pittsburgh's Starling Marte and Mets outfielder Eric Young Jr.
• Cubs shortstop Starlin Castro is hitting .314 with four doubles, two homers and seven RBIs in his last 12 games.
Paul Casella is a reporter for MLB.com. Follow him on Twitter @paul_casella. This story was not subject to the approval of Major League Baseball or its clubs.


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Jim Walsh on Budget & EconomyRep./Ind./Conservative Representative (NY-25) |
Proponent's argument to vote Yes:Rep. BARNEY FRANK (D, MA-4): This economy is in the worst shape that it has been in since the Great Depression. This Congress voted 2 months ago to advance $25 billion to the auto industry to promote innovation. This $15 billion is an additional "bridge loan."
Opponent's argument to vote No:Rep. SPENCER BACHUS (R, AL-6): We all understand that the bankruptcy of either GM or Chrysler would have a cascading effect on other manufacturers. But I cannot support this plan because it spends taxpayer money without any real promise to return the industry to profitability. I see several glaring flaws. We are creating a new car czar to manage these companies from Washington; not a CEO, but a car czar. Second, this legislation actually imposes new and expensive mandates on our automobile companies. Third, this legislation imposes Federal Government management on the Big Three, the wisdom of Washington. It is clear that the management of these companies have made mistakes, many mistakes, but to set up a command and control Federal bureaucrat is exactly the wrong solution.
Rep. RON PAUL (R, TX-14): The problems that we are facing today date back to 1971. But we don't seem to want to go back and find out how financial bubbles form and why they burst. Instead, we just carry on doing the same old thing and never look back. We spend more money, we run up more debt, we print more money, and we think that is going to solve the problem that was created by spending too much money, running up debt, printing too much money. Today, we are talking about tinkering on the edges without dealing with the big problem.
Proponent's argument to vote Yes:Rep. DAVID OBEY (D, WI-7): Congress has tried to do a number of things that would alleviate the squeeze on the middle class. Meanwhile, this economy is sagging. Jobs, income, sales, and industrial production have all gone down. We have lost 600,000 jobs. We are trying to provide a major increase in investments to modernize our infrastructure and to provide well-paying construction jobs at the same time.
Opponent's argument to vote No:Rep. JERRY LEWIS (R, CA-41): Just 2 days ago we were debating an $800 billion continuing resolution. Now in addition to being asked to pay for a bailout for Wall Street, taxpayers are being asked to swallow an additional $60 billion on a laundry list of items I saw for the first time just a few hours ago. The Democratic majority is describing this legislation as a "stimulus package" to help our national economy. But let's not fool ourselves. This is a political document pure and simple. If these priorities are so important, why hasn't this bill gone through the normal legislative process? We should have debated each of the items included in this package.
It doesn't take an economist to tell you that the economy needs our help. But what does this Congress do? It proposes to spend billions more without any offsets in spending. The failure to adhere to PAYGO means that this new spending will be financed through additional borrowing, which will prove a further drag on our struggling economy.
SUPPORTER'S ARGUMENT FOR VOTING YES:Rep. WATERS: This bill preserves public housing. The administration eliminated the one-for-one replacement requirement in 1996, effectively triggering a national sloughing off of our Nation's public housing inventory. Housing authorities have consistently built back fewer units than they have torn down and, as a result, over 30,000 units have been lost. I urge you to support our Nation's low-income families and to preserve our housing stock.
OPPONENT'S ARGUMENT FOR VOTING NO:Rep. HENSARLING: President Reagan once said that the nearest thing to eternal life on Earth is a Federal program, and I don't think there is any better case study than perhaps the HOPE VI program. If there was ever a program that cried out for termination, it's this one.
This program began in 1992 with a very noble purpose of taking 86,000 units of severely distressed public housing and replacing them, demolishing them. Well, it achieved its mission. But somewhere along the line we had this thing in Washington known as mission creep.
We already have 80-plus Federal housing programs, and the budget for Federal housing programs has almost doubled in the last 10 years, from $15.4 billion to more than $30 billion now. So it's very hard to argue that somehow Federal housing programs have been shortchanged.
LEGISLATIVE OUTCOME:Bill passed House, 271-130
Proponents support voting YES because:
Rep. FRANK: This legislation seeks to prevent a repetition of events that caused one of the most serious financial crises in recent times. We have a worldwide problem economically, with a terrible shortage of credit. Innovations in the mortgage industry, in themselves good and useful, but conducted in such a completely unregulated manner as to have led to this crisis. The fundamental principle of the bill is not to put remedies into place, but to stop future problems from occurring in the first place. We have had two groups of mortgage originators: banks subject to the regulation of the bank regulators; and then mortgage loans made by brokers who were subject to no regulation. The secondary market has been on the whole useful but, having been unregulated, has caused some problems.
Opponents recommend voting NO because:
Rep. HENSARLING: This is a bad bill for homeowners in America. There is no doubt that this Nation faces a great challenge in the subprime market, but this piece of legislation is going to make the situation worse. Clearly, there has to be enforcement against fraud in the subprime market. But what Congress should not do is essentially outlaw the American Dream for many struggling families who may be of low income, who may have checkered credit pasts, for whom a subprime mortgage is the only means to purchase a home.
[As part of the Contract with America, within 100 days we pledge to bring to the House Floor the following bill]:
The Fiscal Responsibility Act:
A balanced budget/tax limitation amendment and a legislative line-item veto to restore fiscal responsibility to an out-of-control Congress, requiring them to live under the same budget constraints as families and businesses.
What we offer today are not the precise spending decisions of a given year's budget; rather, we call upon the Congress and the nation to adopt the following guidelines for our fiscal policy over the next decade. This long-term blueprint is essential for maintaining both the immediate public-sector goal of balancing the budget and the private-sector goal of a healthy economy. This can be achieved through the following steps:


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Iwan Rheon Gossip
Iwan Rheon gossip, latest news, photos, and video.
Game of Thrones 5.2: "Nothing's worth anything to dead men"
FameFlynet, Simon Earl/ Splash News
Game of Thrones Season 5, Episode 2 recap I try really hard not to get invested in anyone on this show because they inevitably die in horrible ways, but Arya Stark is my tomboy spirit animal. This episode has less of a place-setting feel than last week, but we still have to establish where Arya is (as well as what's going on in Dorne). Full Story
Future Simon & The Seven Kingdoms
Wenn, James Higgins/Splash, Keystone
OK, let me get this out the way first: (SCREAMING) - why don't you watch Misfits??? How come you know more about the last 4 seasons of Dancing With The Sh-ts than you do about Superhoodie and his degenerate friends? I'm done. And have you heard? In my world it's the equivalent of Harry Potter marrying Mariah Carey. Full Story
Simon is a gangster
Dave Hogan /Getty Images
As promised, I will do my best to post pictures of the Misfits cast whenever they've available. Check it - Iwan Rheon at the premiere of Wild Bill in London tonight. He plays a low level thug. Oh look! It's Andy Serkis in real life, no motion capture!And how is Simon/Iwan? Well, IMDB says he's shooting a movie with Neville Longbottom. Full Story
Misfits for America is impossible to play
Wenn, Mike Marsland/Dave M. Benett/Getty
If you missed my review of Misfits series 3 over the holidays, click here.A spec pilot was submitted to US networks this week for an American version of my beloved Misfits. It was written by Josh Schwartz (The O.C., Gossip Girl etc) and Howard Overman, the creator of Misfits. Full Story
Misfits Series 3
MAJOR SPOILERS AHEAD. Please click away if you haven't yet caught up on Misfits Series 3. And if you're not watching Misfits, I'm telling you, this is your holiday addiction. DO IT. Seasons 1 and 2 are available on iTunes. I'll give you another chance to skip this article to avoid spoilers………………………………………………………He's a ballsy motherf-cker, isn't he, Howard Overman? Many of you have written to express your outrage and despair that Alisha and Simon are no more. Full Story
The new Misfit
Misfits season 3 is now shooting. Yes, yes, without Robert Sheehan. Like I've been saying, I don't think I'll miss him. I don't miss him already. And besides, again as I've been saying, Nathan was becoming less and less interesting to me. You would have tired of him scratching his balls and the high pitched voice. Full Story
Misfits: Lauren wins, Robert talks
HAVE YOU STARTED WATCHING THIS SHOW YET? It's easy online. Try it. The BAFTAs happened on Sunday honouring the best of British television. Misfits won in the drama category last year. There was no repeat but Lauren Socha, aka Kelly, took home Supporting Actress. Yay! All five original actors were on hand for the event. Full Story
Down one orange jumpsuit
If you are just getting into Misfits, please note there is a MAJOR spoiler below. Might want to avoid. If you are not yet into Misfits, I will keep yelling at you to get into it because, well, frankly, the longer you put it off, the longer you're depriving yourself of amazing, irreverent, no dancing sh-t tv. Full Story
Misfits minus one
I'm not done nagging you to watch Misfits. The dvds are available. The episodes are on YouTube. You have no excuse to deprive yourself of one of the most kick ass tv experiences in recent memory. Trust me. The converted have been emailing me consistently about it. There's euphoria. And then there's distress. Full Story


text: I'm not on here much anymore, but for those of you who know me and my dog Chica, she passed away today. I'm on a bunch of other forums, but none of them really know me like some of the people on here. So this is the only one I'm posting anything like this on. She was 13 and such a love of my life. She held me together through rough times. At one time, I leaned on her really hard and cried on her, then RockerBob called me and cheered me up. I'm not on Facebook, even though my wife made a page for me, so I don't know how many of the old folks are on here or who will see it. She was one of those "one of a kind" dogs that everyone loved, including our cat, who would rub up against her when he came in. I loved her sooo much


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Hello folks, yes the TEN FOOT LONG big @$$ type 7 is for sale. Maybe a week or two's worth of work away from being back on the water. It has the conning tower, Ballast system, drive system, servos, stainless tanks & superstructure all included, it will need a radio & some tweaking. Please contact me directly online here, or at 818 652-3395... OR at email@example.com & we can discuss things. I will not be able to ship as it's big (over 10 feet) & heavy (well over 100 LBS.) so you will have to come-n-get it! (unless you're close-ish... pay for gas & lunch)? ... I like lobster
How much???I just lowered my price!!! (again) I would like $1,750 for it, Let's talk... I STILL have (LOTS of) bills to pay.
t's a bit dusty & dirty, has a few cracks from exposure & will need a touch of glassing here & there...but you can get the idea. Why get an itty bitty 32'nd paralell boat or that "tiny" Robbe boat when you can super size!
Ok ok enough corn, it's a great boat & a once in a lifetime chance at getting something that will possibly even impress your wife/girlfriend!
Thank you very much for looking... now GET THIS SUBMARINE OUT OF HERE DAG NABBIT!


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The N'DIGO Foundation is a 501(c)(3) private charity dedicated to rewarding excellence in education by awarding merit-based college scholarships to Chicago and surrounding suburban students in High School. Since 1995, the N'DIGO Foundation has continued its tradition of presenting merit-based college scholarships to students in partnership with numerous colleges and universities, corporations, foundations, community organizations and generous individuals. The N'Digo Foundation has awarded over 225 scholarships since its inception.
If you would like to make a "tax-deductible" donation, please make your check(s) payable to: The N'DIGO Foundation. And mail to: The N'DIGO Foundation 1006 South Michigan Avenue, Suite 200 Chicago, Illinois 60605 Any questions, feel free to contact us at: 312.822.0202


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Louisiana Tech Bulldogs Gear
Louisiana Tech Bulldogs Ladies
Louisiana Tech Bulldogs Ladies Accessories
(25 items)
Product ID: 1013795
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Order as many items as you like with our $4.99 flat rate shipping.
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What kind of Louisiana Tech fan are you? Tough but sweet--that's how you'd describe your Bulldogs fanaticism. Show off that unique brand of team pride with this Heart and Wings faux leather bracelet. It features the La-Tech logo inside a rhinestone-accented heart and wing pendant and a heart-shaped lobster claw closure. This bracelet is the perfect pronouncement to anyone who's wondering -- you can dish it out in the stands, but look pretty cute while doing it!
- Lobster claw closure
- Measures 7.5" in length
- Officially licensed collegiate product
- Rhinestone accents
- Team logo charm
Bulldogs Customers also liked:
Special event items are produced by manufacturers only after the outcome of a game
or event. These are advanced sale items and will ship immediately after they are
received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items
are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite
number, and/or designs. Some options may be limited by league rules.


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Advancing freedom and prosperity by unleashing free enterprise, protecting...
Read more about Energy & Environment
Demand is increasing faster than supplies while much of the world's oil is delivered in a restrictive market dominated by unstable or hostile nations. Meanwhile, many Americans harbor misunderstandings and myths about energy, the environment, and market forces. They want low prices and plentiful supply, but resist steps that must be taken to achieve these goals. They want to protect the environment but most plans have huge costs and questionable benefits. This confusion leads Congress to enact conflicting policies that harm the nation's ability to meet its energy needs. Sound policies must enable America to obtain supplies from a wide range of sources in a way that is best for the economy and also addresses homeland and national security considerations.
1.To unleash the creativity of free enterprise to meet America's energy and environmental needs.
2.To protect America's energy interests.
3.To advance free global energy markets.
Slapping the word "rural" in front of a bunch of green subsidies doesn't mean they're not subsidies. But that's exactly what the Rural Energy Investment Act section of the Senate version of the farm bill legislation does.
Read More
It's been five years since TransCanada announced the Keystone XL expansion project, but we're still without a pipeline and the jobs and the energy that come with it because no presidential permit for construction has been authorized.
How the Administration is Holding Up Progress
All Americans want a clean, healthy, and safe environment. Yet an important question remains: Which public policies will realize our environmental goals most effectively? Heritage's Environmental Conservation explores the principles that should shape American environmental policy.
A bill to reform nuclear waste management in the U.S. does little to combat the current, failed system. Policies that introduce market forces and corporate responsibility are the key that could finally unleash the nuclear renaissance.
Say you were a politician and there was a clean and abundant domestic energy source — one that has the potential to create jobs and revitalize local economies. You'd do more to encourage it, right?
Is Nuclear Energy Safe? Can It Help Meet Our Energy Needs? Powering America answers these questions and more by pulling back the veil on nuclear energy.
Watch the Film Now
The Climate Protection Act of 2013 (Boxer–Sanders bill) would inflict high costs on families, and would be a step in the wrong direction for tax reform.
Although an international consensus addressing the issue of climate change has not been reached, the Obama Administration insists the U.S. carry the torch on this challenge through a series of unilateral actions. Even if it's detrimental to the economy.
Receive weekly updates on the ongoing policy battles in Washington and around the country.
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America's primary environmental goal should be a cleaner, healthier, and safer environment for current and future generations. Yet, governing environmental laws have strayed far from intended purposes, and their implementations are imposing immense costs on Americans with few benefits in return.
A complete disruption of Saudi oil production would significantly affect global energy markets and overall economic activity. The United States needs to prepare domestic and international measures before such a disruption occurs.
Posted June 3, 2014 by Nicolas Loris
Posted May 28, 2014 by Nicolas Loris
Posted May 7, 2014 by Nicolas Loris
Posted May 5, 2014 by Daren Bakst
Posted March 13, 2014 by Nicolas Loris, Jack Spencer
America has an energy addiction – and it's not an addiction to oil.
The administration's SunShot initiative is burning American taxpayers.
Posted October 28, 2013 by James Jay Carafano, Ph.D.
Posted October 28, 2013 by David W. Kreutzer, Ph.D.
Posted July 25, 2013 by Nicolas Loris
Posted June 27, 2013 by Nicolas Loris
Posted June 11, 2013 by Nicolas Loris, Katie Tubb
Posted September 20, 2013
Posted September 12, 2013
Posted July 8, 2013
Posted June 29, 2013
Posted May 30, 2013
Posted May 15, 2013
Posted February 27, 2013
Posted April 19, 2012
Posted April 3, 2012
Posted April 2, 2012
Jack Spencer oversees Heritage Foundation research on a wide range of domestic economic and trade issues Vice President for the Institute fo...
David Kreutzer is the Research Fellow in Energy Economics and Climate Change at The Heritage Foundation's Center for Data Analysis. ...
Nicolas (Nick) Loris, an economist, focuses on energy, environmental and regulatory issues as the Herbert and Joyce Morgan fellow at The Her...
Derrick D. Morgan is the Vice President for Economic Freedom and Opportunity at The Heritage Foundation. Morgan directs all research on econ...
Becky Norton Dunlop's duties and travel itinerary as The Heritage Foundation's vice president for external relations have made her the t...
As senior advisor for strategic outreach, Robert Gordon establishes and builds working relationships with new audiences and potential allies...
Rediscovering our principles in order to reclaim our future.
Advancing American leadership and freedom in the world.
Strengthening American education by returning authority to the states and...
Eliminating barriers to enterprise and innovation.
Replacing the culture of entitlements with one of mutual responsibility.
To sustain freedom and the common good, family and religion are central
Providing every American freedom of choice in health care.
Protecting America and Americans from freedom's enemies.
Reestablishing the rule of law as the foundation for constitutional...


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Our successful fall season has come to an end and we are headed indoors for our winter training schedule. We are looking to finalize two spots on our 12U team this season as we prepare for our 2012 Spring/Summer tournament schedule. As a full-time tournament team we are excited about the caliber of talent we have assembled and our prospects for upcoming season. If you are interested in checking out these opportunities (looking primary for an infielder and pitcher, but will look at all experienced softball players), please contact Brian Ollech at 312-307-5840 for more information and to schedule a private tryout.
I was wondering if you found the players you were looking for. We are looking for a travel team. Could you please let me know? If we missed it, could you let me know when the next tryouts will be held?
Please give me a call soon at my cell (312-307-5840) and we can discuss our status for this season and next year's tryout timing. Thanks for your interest. Brian
Are you still looking for a player?
Online Golf Tee Times with Last Minute Tee Time Deals & Discounts
Cool Running is the complete online resource for runners.
Find your favorite campground from the best campgrounds listing!


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What to Look for in Polarized Fishing Sunglasses
Find out how helpful a pair of polarized fishing sunglasses can be for you and your fishing experience.
Reducing Glare
Glare reduces your ability to see underwater structures and spot fish. It causes eyestrain and fatigue. None of which will make your day on the water more productive or more enjoyable. Good quality polarized lenses are designed to eliminate 99% of all reflective glare and protect against harmful U.V. rays. There are many options to choose from today, so be sure to understand the different choices you have when selecting the right pair of sunglasses for you.
Lenses for All Conditions
There are an array of different lens materials and tints available to cover almost any fishing condition you may encounter.
Pros and Cons of Lens Materials
Lens Tints
Excellent for day to day use. Gray lenses transmit all colors of the spectrum so there is little distortion. Ideal for bright sunny days and open water fishing.
Copper is a very high contrast lens that is soothing to the eyes. It absorbs blue light, heightening visual acuity and boosting contrast, making this lens the best choice for sight fishing applications.
Considered by many to be the best all-around tint for fishing. Provides excellent contrast and true color perception. Great for shallow water stream and flats fishing in medium to bright light.
Excellent for low light conditions such as first and last light or heavily overcast days.


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A lot of years passed since the first hardware accelerated sound card appeared (the SB Live!) and still there isn't a Linux implementation that takes advantage of that via OpenAL.
Nor Creative with Live!, Audigy, X-FI, nor Cirrus Logic with Crystal Media chips on Maxi Sound Fortissimo, nor Asus with Xonar ...
No company put effort on that, and no comunity effort on reverse-engineering.
Seems that reverse-engineering graphic drivers worth, and sound ones not.
Now, in graphics drivers we are not too far Windows, but sound ones need more coders.