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US 4174961 A Abstract A new method is disclosed for recovering elemental iron and manganese present in oxide form in waste slag obtained from oxygen steel production. The metal oxides are reduced in the presence of carbon or carbon combined with a coal mine waste material and an Al2 O3 -containing additive present in the form of a silicate.
Claims(7) 1. A method of treating waste slag from oxygen steel production (L.D.-slag), involving reduction of iron and maganese oxide being present in the slag to their metals after addition of an Al2 O3 -containing additive and heating the total composition, the iron and the manganese being subsequently separated therefrom, which comprises the steps of:
(1) mixing said L.D.-slag and said Al2 O3 -containing additive being present in the form of a silicate selected from the group consisting of at least one of the waste products of coal mine products including stone-sludge, fly ash, schists, clays, clay-containing waste materials and blast furance slag; (2) mixing said L.D.-slag in a ratio of 55-971/2 parts to 45-21/2 parts of said Al2 O3 -containing additive: (3) mixing said L.D.-slag with carbon, or with carbon combined with carbon-containing coal mine waste materials; (4) heating the composition so obtained to a temperature of between about 1250� C. to 1500� C., and allowing reduction of said iron and manganese oxides during heating; and (5) recovering iron and maganese in molten state from the slag. 2. A method according to claim 1, step (2) wherein 55 to 80 parts of L.D.-slag are mixed with 45 ot 20 parts of schist (calculated as ash).
3. A method of treating the waste slag from the oxygen steel production (L.D.-slag), involving reduction of iron and maganese oxides being present in the slag, to their metals after addition of an Al2 O3 -containing additive and heating the total composition, the iron and the manganese being subsequently separated therefrom, which comprises the steps of:
(1) mixing said L.D.-slag and said Al2 O3 -containing additive being present in the form of a silicate selected from the group consisting of at least one of the waste products of coal mines including stone-sludge, fly ash, schists, clays, and clay-containing waste materials and blast furnace slag; (2) mixing said L.D.-slag and said Al2 O3 -containing additive in such amounts to obtain a total composition expressed in terms of the oxides CaO, Al2 O3 and SiO2 in a ratio falling within the area defined by the following three weight percentage points on a triangle phase diagram, plotted for a temperature of 1350� C.: ______________________________________ CaO Al2 O3 SiO2______________________________________1 55 3 422 60 28 123 70 4 26______________________________________ (3) mixing said L.D.-slag and said Al2 O3 -containing additive with carbon, or with carbon in combination with said coal mine waste materials; (4) granulating said composition; (5) heating said granulated composition up to about 1400� C. and allowing reduction of said iron and manganese oxides during heating; (6) subsequently cooling said heated granules to between about 180� C. and 230� C.; and (7) recovering finely divided iron and manganese particles from said cooled and spontaneously disintergrated granules. 4. A method according to claim 3, wherein the ratio of the oxides CaO, Al2 O3 and SiO2 of said composition is adjusted close to the line connecting said points 1 and 2 in said triangle phase diagram.
5. A method according to claim 3 wherein the heated granules are cooled to about 200� C.
6. A method according to claim 1 wherein after recovering the iron and manganese during step (5) the remaining slag is converted to a portland cement clinker, after adding materials containing a high CaO or CaCO3 content.
7. A method according to claim 3, wherein after recovering the iron and manganese in step (7) the remaining slag is converted to a portland cement clinker, after adding materials containing a high CaO or CaCO3 content.
Description The invention relates to a method for working-up waste slag from the oxygen steel production (hereafter to be called L.D.-slag), said method comprising reducing metal oxides being present in the slag to metal by means of a reducing agent and with the addition of an Al2 O3 -containing additive and separating them from the slag. In certain areas often large amounts of slag are found, originating i.a. from the method of the oxygen steel production, the so-called "L.D.-slag". This slag, contrary to blast furnace slag, after cooling (quenching) is not hydraulic and so not very valuable. The possibility of recycling the slag in a blast furnace to extract the iron is limited as a result of accumulation of undesired elements. The waste piles of this slag can so be considered as being detrimental to the environment. The main components of the L.D.-slag are usually within the following limits: ______________________________________SiO2 7 - 18% by weightAl2 O3 0.3 - 2% by weightCaO 35 - 55% by weightMgO 2.6 - 6% by weightFe + FeOx 15 - 40% by weightMnOx 2 - 6.5% by weightP2 O5 1 - 2.5% by weight______________________________________ The iron content of the slag is such that extraction of iron from the slag appears useful. Extraction of the iron from the slag by a simple reduction treatment is difficult and economically little renumerative. In a reducing atmosphere at a temperature of about 1200� C., it is true, metallic iron is formed, but this iron remains finely divided in the pores of the remaining slag because the temperature at which this slag becomes liquid is considerably increased by reducing the iron compounds. The iron can hardly be separated from the remaining slag. French patent application No. 73 05145 shows a method to extract metal from a L.D.-slag, with which method also a slag that can still be used for certain applications is obtained. One starts from a liquid L.D.-slag, to which bauxite is added. Starting from a liquid L.D.-slag the reduction still takes place at about 1600� C. by means of a solid reducing agent such as carbon or aluminium. In areas where bauxite is a relatively expensive raw material, said method is not very attractive. One of the examples, however, indicates that besides Al2 O3 also SiO2 can be added to the flux, a slag being obtained that after cooling and grinding has hydraulic properties. Energetically this method is not attractive, especially if one would start from an already cooled slag (dumped material). British Pat. specification No. 922 586 shows the extraction of iron from a slag, but this method is no more than a modified blast furnace process by the use of coke, iron ore and lime and cannot be used for the L.D.-slag. The remaining slag still contains rather much iron. The purpose of the invention is to provide a method for working-up L.D.-slag, said method allowing (a) extraction of metal from the slag by reduction at relatively low temperature and not necessarily in the liquid phase, whereby advantageously an already cooled L.D.-slag (dumped material) can be used as starting material; (b) the use as a flux additive of a material having a lower Al2 O3 -content than bauxite, preferably a waste material; (c) the separation of slag and metal at a relatively low temperature and preferably in a technologically simple way; while (d) the remaining slag is an industrially useful product which preferably can be simply converted into a normal portland- or blast furnace cement. According to the invention this purpose is reached if the L.D.-slag is mixed beforehand with an additive (additives) at least containing the oxides of aluminium and silicon, said additive(s) being used in a ratio of 45-21/2 parts of additive to 55-91/2 parts of L.D.-slag and with carbon as a reducing agent and the reduction mainly takes place in the solid phase, whereafter between about 1250� C. and 1500� C. the iron is separated from the newly formed slag and is subsequently removed. Preferably a temperature between about 1350� C. and 1450� C. is used. After adding lime the newly formed slag can be converted into a portland cement clinker. By lime, materials are meant being high in CaO- or CaCO3 -content. The complete L.D.-slag can be converted into valuable products according to the above method. Preferably as an additive at least containing the oxides of aluminium and silicon aluminium silicates are used, but in a further embodiment of the method still to be discussed also other additives can be used. An important aspect of the invention is that it is distinguished that simultaneously also other materials being detrimental to the environment can be used as additives and thus can be converted into a suitable product. This applies especially to the waste products of coal mines often to be found in the neighbourhood of steel industry, such as mine stones or stone sludge. Said waste products also often contain 15 up to 24% by weight of carbon which can simultaneously be used as a cheap reducing agent so that no or only a small amount of other reducing agents being rich in energy is necessary. This waste material can e.g. (not limitatively) have the following composition: inorganic components, for the major part aluminium silicates (determined as "ash", and hereafter to be called "schist ash") 68% by weight; loss on ignition, for the greater part carbon 32% by weight the analysis of the schist ash comprises: SiO2 --56% by weight Al2 O3 --25% by weight CaO--3% by weight Fe2 O3 --8% by weight. Besides these waste products from coal mines also fly ash being detrimental to the environment can be used. The chemical composition hereof corresponds with the one of schist ash. Also fly ash, schist, stone sludge, clays or clay-containing waste materials and the like can be used separately or mixed with each other. In French patent application No. 73 05145 it is not distinguished that it is possible to use also aluminium silicates instead of bauxite, such as the mentioned waste materials of coal mines. The ratio of L.D.-slag to added aluminium silicate can be varied within broad limites, dependent on the nature of the added aluminium silicate and the nature of the remaining new slag that is desired. The amounts can be between 55-971/2 parts of L.D.-slag and 45-21/2 parts of the aluminium silicate-containing materials. If one starts from waste stone of coal mines in a ratio being somewhat dependent on the composition of said stone, of 55-80 parts of L.D.-slag and 45-20 parts of schist (calculated on ash), then after separation of metal at 1350� up to 1450� C. a liquid slag is obtained, the composition of which is approximately the same as the one of a normal blast furnace slag. This slag after quenching can be processed into a hydraulic binding agent or as such be converted into portland cement clinker in a known way by applying lime. Separating iron in the liquid phase has a number of disadvantages. Especially a rotary kiln cannot simply be used for said purpose. According to the present invention it is possible to avoid these disadvantages if according to a preferred method to the L.D.-slag so much additive is added that in the slag calcium silicate is present having the composition 2 CaO.SiO2. This material has the property to disintegrate into a fine powder under the right cooling conditions and when present in the slag in a sufficient amount in the slag also can disintegrate said slag into a fine powder. So more specifically to the L.D.-slag so much additive is added that the resulting slag in a triangular diagram (FIG. 3) representing the percentages of CaO, Al2 O3 and SiO2 is within an area of which, for a temperature of 1350� C., three vertices can be indicated having the following compositions: ______________________________________% CaO %Al2 O3 % SiO2______________________________________1. 55 3 422. 60 28 123. 70 4 26______________________________________ Every composition of the slag within the area comprised by these three vertices appears to lead to the spontaneous disintegration of the formed slag into a fine powder during cooling to about 200� C. It was also found that the metallic iron is present in the formed slag in finely divided state. After cooling and disintegration of the slag the iron particles then being present in the powder can easily in a known way be separated from the powder, e.g. by magnetic forces, by air separator and the like. Surprisingly it also appeared that the size of the iron particles can be influenced. If additives are added such that the composition of the slag is close to the line connecting the points 1 to 2 the iron particles are considerably larger than the slag particles and with a composition close to the point 3, however, their size does not differ much from the size of the slag particles. Therefore, for a good separation of iron and powdery slag the composition will as much as possible be adjusted in the first mentioned area. Said composition can be obtained by adding as an additive 20-21/2 parts of aluminium silicate, e.g. schist with respect to 80-971/2 parts of L.D.-slag. In order to reach the same result also many other additives can be added. These other additives comprise aluminium oxide and silica containing materials: blast furnace slag, Rotschlamm and the like. The formed powder after separating the iron can be converted into portland cement clinker in a known way by means of lime. A great advantage herewith is that the slag is already available as a fine powder and that in the slag lime in decarbonated form is present. A practical embodiment of the above mentioned preferred method consists in that L.D.-slag, additive and carbon are granulated, the granules are dried in a rotary kiln, are reduced and sintered, the granules are subsequently cooled to about 200� C. while recovering the heat, whereafter the iron is separated from the disintegrated slat. This method with granules has the great advantage that in a simple way a rotary kiln can be used. The iron is initially included in the granules and hardly reoxidises. FIG. 1 is a flow-sheet of a possible treatment of L.D.-slag with additives for preparing iron and portland cement clinker by means of rotary kilns, in accordance with example 1 below; FIG. 2 is a schematic of a variant of the preferred method; and FIG. 3 is a triangular diagram representing the percentages of CaO, Al2 O3 and SiO2. The invention is illustrated by means of examples. In a laboratory mill (disk vibrating mill) 80 grammes of L.D.-slag, chemical analysis (all in percentages by weight): CaO--36.2%, SiO2 --13.5%, Al2 O3 --1.9%, MgO--4.4%, Fe2 O3 --34.1%, Mn--4.4% and P2 O5 --1.5%, were ground during 2 minutes together with 40 grammes of schist waste from a coal washery. The chemical analysis of the schist was: CaO--1.2%, SiO2 --36.9%, Al2 O3 --17.1%, MgO--1.5%, Fe2 O3 --5.0%, P2 O5 --0.2%, loss on ignition--32%. The thus prepared raw materials were introduced into a crucible of sintered aluminium oxide and electrically heated in a resistance furnace up to a furnace temperature of 1400� C. A reducing furnace atmosphere was maintained by placing the above mentioned crucible in a larger one, the bottom of which being covered with carbon. After a period of 30 minutes at 1400� C. the crucible was removed from the furnace and cooled in the air to room temperature. Hereafter the content of the crucible was examined. On the bottom of the crucible iron had been collected. The weight hereof was 21.7 grammes and the chemical analysis: Fe--94%, P--1.4%, Mn--0.9%, C--2.4%, Si--0.0%. Over the iron there were 76 grammes of slag, the chemical analysis of which was: CaO--38.2%, SiO2 --33.2%, Al2 O3 --12.4%, MgO--5.4%, Fe2 O3 --1.2%, MnO--3.9% and P2 O5 --0.2%. In a laboratory mill 50 grammes of the obtained slag were ground during 2 minutes together with 105 grammes of limestone with chemical analysis: CaO--50.6%, SiO2 --6.2%, Al2 O3 --0.9%, Fe2 O3 --0.4%, MgO--0.8% and an ignition loss of 40.9%. The obtained powder was pressed into a tablet, whereafter the tablet was introduced into a platinum crucible and electrically heated in an resistance furnace to a furnace temperature of 1450� C. After heating for 30 minutes at 1450� C. in an oxidizing atmosphere the crucible was removed from the furnace and cooled in the air. The sintered tablet was microscopically examined; the material appeared not to deviate mineralogically from normal portland cement clinker. A L.D.-slag with chemical analysis (all percentages by weight): CaO--39.2%, SiO2 --12.9%, Al2 O3 --1.9%, MgO--5.2%, Fe2 O3 --33.8%, MnO--4.9% and P2 O5 --1.7% and schist with chemical analysis: CaO--0.4%, SiO2 --39.8%, Al2 O3 --15.2%, MgO--1.4%, Fe2 O3 --4.8%, ignition loss--34.2% and pure carbon, were used for preparing mixtures A and B. Mixture A consisted of 100 grammes of L.D.-slag, 15.1 grammes of schist and 4.5 grammes of carbon. Mixture B consisted of 100 grammes of L.D.-slag, 20.4 grammes of schist and 3.3 grammes of carbon. The mixtures A and B were separately ground in a laboratory mill (disk vibrating mill) during 2 minutes and thereafter granulated with water to granules of about 2 cm. The obtained granules of the mixtures A and B were separately introduced into a crucible of sintered aluminium oxide, lined at the inner side with a thin layer of silicon carbide and electrically heated in a resistance furnace up to a temperature of 1400� C. A reducing atmosphere was maintained in the crucible by covering said crucible with a refractory plate. After a period of 60 minutes at 1400� C. the heating was switched off and the furnace allowed to slowly cool down to 800� C., whereafter the crucible was removed from the furnace and further cooled in the air. The granules of sample A spontaneously disintegrated at a temperature of 230� C. while the granules of sample B disintegrated at 180� C. In both cases the iron was present in the disintegrated material as agglomerated granules. The measured particle size distribution of the iron and the remaining disintegrated slag are shown in weight percentages in the following table. TABLE______________________________________Sample A B______________________________________Fractions Slag Iron Slag Iron0.20 μm 50.5% 15.0% 61.1% 5.9%20-40 μm 35.4% 30.6% 32.1% 15.7%40-63 μm 1.7% 28.2% 0 % 24.6%63-150 μm 12.0% 18.4% 4.1% 23.7%> 150 μm 0.4% 7.8% 2.7% 30.1%______________________________________Totally 100% 100% 100% 100%______________________________________ From the table it appears that the granule distribution of the iron in sample B is coarser than in sample A. This is in agreement with the fact that the composition of the slag of sample B is closer to the line connecting the points 1 to 2 in the said triangular diagram. The invention is further illustrated by means of a drawing. FIG. 1 is a flow-sheet of a possible treatment of a L.D.-slag with additives for preparing iron and portland cement clinker by means of rotary kilns, in accordance with example 1. It is explicitly stated that the application of the present invention on a technical scale is not limited to the embodiment according to the example. Other technical embodiments are possible, e.g. with other furnaces than rotary kilns. In the flow-sheet of FIG. 1 at 11 L.D.-slag and at 12 schist (e.g. the waste stone of a coal mine) are supplied to a crusher 13 crushing the raw materials. At 14 the broken product is supplied to a rotary kiln 15 wherein the iron compounds of the L.D.-slag are reduced by the carbon being present with the schist, optionally supplemented with an other reducing agent. At 16 heating gas is supplied to bring the mass in the furnace at the desired temperature. In the furnace the mass finally melts at about 1400� C. and at 17 from the melt separated pig iron can be drained off. By means of a drain 18 finally the remaining new slag is extracted. Said slag is brought to a mixer 110 via route 19 in liquid form or after cooling in solid form. At 111 wet or dry finely divided limestone or chalk is supplied to a heat exchanger 112 (e.g. a drum) and is preheated. For the benefit of this preheating flue gases of the rotary kiln 15 and the sintering furnace 113 still to be discussed can be used, which gases are supplied via a flue gas channel 114. The heat exchanger 112 is of course provided with a dust discharge 115, a flue gas fan 116 and an electrofilter 117 for catching the finest dust while the flue gases are released in the atmosphere via chimney 118. The preheated 37 meal" from the heat exchanger 112 is also introduced into the mixer 110 (optionally with dust separated in 115 and 117) and after mixing with the slag which was extracted at 18 is supplied to the sintering furnace 113. The supplied hot mixture 119 of slag and limestone meal is heated in the sintering furnace 113 up to about 1400� C., for which purpose at 120 heating gas is introduced. The sintered product is cooled in a cooler 121 and at 122 is discharged as portland cement clinker for further processing to cement. In the following table finally a raw material balance is given for producing pig iron and portland cement clinker according to the method of the invention, which method can be carried out with a device as schematically described above. One starts from 1000 kg of L.D.-slag as well as schist from a coal mine. The composition of the raw materials and products are expressed in kg of the oxide of the elements, determined from the chemical analysis. ______________________________________ ProductionProduction of pig iron of clinkerStarted from Obtained Added ObtainedL.D.-slag schist pig iron slag limestone clinker______________________________________SiO2 135 185 0 (Si) 320 126 446Al2 O3 19 86 -- 105 18 123MnO 44 -- 3 (Mn) 40 -- 40CaO 362 6 -- 368 1027 1395MgO 44 7 -- 51 17 68K2 O 0 19 -- 19 1 20Na2 O 9 2 -- 11 -- 11SO3 2 6 -- 8 -- 8P2 O5 14 1 5 (P) 3 -- 3Fe2 O3 341 25 248 (Fe) 11 8 19Rest 30 3 7 33 3 36Ignitionloss -- 160 -- -- 830 --______________________________________Totally 1000 500 263 969 2030 2169______________________________________ Starting from 1000 kg of L.D.-slag with the composition of the raw materials mentioned in the example one obtains: 263 kg of pig iron and 2169 kg of portland cement clinker. Herefor the following had to be added: 500 kg of schist and 2030 kg of crude limestone (Maestricht chalk). The schist added as "mine stone" has an ignition loss of 32% by weight, caused by the presence of for the major part coal (reducing agent), and, further by carbonates and bonded water. In FIG. 2 a variant according to the preferred method is schematically shown. At 21 L.D.-slag and at 22 flux additive (e.g. schist from a coal mine or another additive) and optionally carbon are supplied to a grinding and mixing device 23 in dosed amounts. The ground and mixed product is first granulated in the presence of water on a granulation disk (or another granulation device). At 25 the granules are supplied to a rotary kiln 26. In the rotary kiln 26 the granules are heated to the desired temperature for which purpose heating gas is supplied at 27. The iron compounds of the L.D.-slag are reduced to iron in the presence of carbon, which iron remains uniformly divided in the granules. At 28 the hot granules leave the furnace 26 and are cooled with air on a grid 29. This air is used as hot combustion air, what provides a favorable energy yield. In the storage 30 the granules are cooled so far that they disintegrate into powder. The disintegrated powder is separated in one or more air separators 31 into fine product 32, which product is substantially "free of iron", and into coarse material. The coarse material is processed in a mill 33 for reducing less good disintegrated slag. In the separator 34 the iron product 35 and remaining slag 36 are recovered. The slags 32 and 36 from which the iron is extracted can in a known way by means of chalk be calcined to portland cement clinker. Summarizing the essence of the invention it has to be appreciated that the L.D.-slag, a material being detrimental to the environment with an other material, respectively materials being detrimental to the environment at relatively low temperature can be converted into pig iron and a material that can be used as a hydraulic product, or a material that can be processed according to usual methods thus forming a hydraulic product. However, the invention is not strictly limited to the use of an additive being a waste material. Another essence of the invention is that it is possible according to a preferred embodiment to use a rotary kiln without complications and to separate the formed iron in a very simple way while the slag becomes available in powder form for further processing into a portland cement clinker. Finally the method is energetically favorable. Patent Citations
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Written by: Cindi Ferrini | Found in: 31 Days of Prayer for your Children, Parenting |DAY 30 : UNITY "And above all these put on love, which binds everything together in perfect harmony." – Col. 3:14 {ESV} One by one, the musicians in the orchestra seat themselves on stage – each warming up by playing scales, notes and parts of the music they've prepared. None of it sounds very good because […]


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World's Greatest Drag Race 2! It's back! The World's Greatest Drag Race returns with nine of the world's best supercars, sports cars, and muscle cars for 2012 facing off in an epic quarter-mile sprint for glory... and ultimate bragging rights! This year's field includes all nine contenders from Motor Trend's 2012 Best Driver's Car competition. We have the Lamborghini Aventador, Nissan GT-R Black Edition, Ford Shelby GT500, McLaren MP4-12C, Jaguar XKR-S, Porsche 911 Carrera S, Subaru BRZ, Mercedes-Benz C63 AMG Black Series and Chevrolet Camaro ZL1 -- all gathered together on an abandoned airstrip at El Toro Marine Base to find out which car is the fastest. Obviously these nine competitors display a wide range of power and performance, not to mention price tags. So why are we lining them all up again for one gigantic, over-the-top drag race? It's simple... Because We Can! World's Greatest Drag Race 2 concludes our special 2012 Best Driver's Car Week here on the Motor Trend youtube channel (http://www.youtube.com/motortrend) and on MotorTrend.com (http://www.motortrend.com). We hope you've enjoyed all of this week's videos and we look forward to rolling out an all-new batch of amazing cars and amazing videos for you next year for Motor Trend's 2013 Best Driver's Car. Read the full story on Motor Trend's 2012 Best Driver's Car here: http://www.motortrend.com/features/performance/1208_2012_motor_trend_best_d rivers_car/ Subscribe now to the Motor Trend youtube channel to make sure you're in on all the action! http://www.youtube.com/subscription_center?add_user=motortrend Facebook - http://facebook.com/motortrendmag Twitter - http://twitter.com/motortrend Google+ - https://plus.google.com/101867967859016552744/posts Website - http://www.motortrend.com
Corvette ZR1 v AC Mk6 - drag race by autocar.co.uk Drag race: Corvette ZR1 v AC Mk6. See autocar.co.uk's Corvette reviews at http://www.autocar.co.uk/corvette/
Factory Five Kit Cars vs a Lamborghini Gallardo! - HOT ROD Unlimited Episode 27 On this episode of HOT ROD Unlimited, the team heads to Vegas to see what's faster: a Factory Five kit car or a 542hp rear-wheel drive Lamborghini Gallardo. Associate Editor Jesse Kiser, Staff Editor Brandan Gillogly and professional driver Mike Essa pilot four of Factory Five's kit cars to see which one's the best on the 1/4-mile, road course, and street. The Mark IV Roadsters feature a 5.0L Coyote V8 and a 427ci from Summit Racing's new line of Factory Five drivetrain packages. HOT ROD Unlimited appears every other Friday on the Motor Trend channel. http://www.youtube.com/motortrend Subscribe now to make sure you're in on all the action! http://www.youtube.com/subscription_c... Facebook - http://facebook.com/motortrendmag & http://facebook.com/hotrodmag Twitter - http://twitter.com/motortrend Google+ - https://plus.google.com/1018679678590... Website - http://www.motortrend.com & http://www.hotrod.com
1968 Dodge Charger at the SEMA Show 2011
1500hp Corvette running on the street!!! This video contains the first and second race. I should have more footage soon. Watch at the very beginning of the video and you'll see the Vette laying black marks all the way down the street. Check out http://www.hightechcorvette.com Follow us on Facebook http://www.facebook.com/hightech.corvette
Corvette Vs. Charger Sorry MOPAR guys.
Bugatti Veyron vs Nissan Skyline GT-R R34
Ferrari Enzo VS Koenigsegg CCX Confira a competição entre a Ferrari Enzo e o Koenigsegg CCX do filme RedLine Velocidade Sem Limites em HD! Vi este vídeo muitas vezes no YouTube, mas sempre com qualidade baixa então agora posto ele novamente só que em HD, para que todos vejam os mínimos detalhes! Check out the competition between the Ferrari Enzo and Koenigsegg CCX, of the movie RedLine in HD! I saw this video in YouTube many times, but always in a low quality, so now I put it in HD so everyone can see all the details! The audio is in Portuguese.
golf vr6 vs challenger GOLF VR6 VS CHALLENGER
2010 camaro ssrs vs 72 chevelle big block More bridge fun. Chevelle won
Steve Clukey intense incar camera in his 70 duster the 145 mph mirror adjust lol.... where is that other guy?
LAMBORGHINI DRAG CAR ( IB6UB9 ) HITS THE WALL AT FULL THROTTLE FRIDAY - 18.2.2011 LAMBORGHINI DRAG CAR ( IB6UB9 ) HITS THE WALL AT FULL THROTTLE FRIDAY - 18.2.2011. MORE VIDEOS TO CoME
Skyline Coming off the Truck Nice ass movie car
Dodge Challenger SRT8 392 vs. Shelby GT350 Video of our muscle car showdown between the 2011 Dodge Challenger SRT8 392 and the 2012 Shelby GT350. Only 1492 Challengers like this one will be built, and Shelby has a cap of 2200, with only 500. Read the Dodge Challenger SRT8 392 vs. Shelby GT350 photos and comparison test here: http://roadn.tk/28
Ford mustang vs Dodge challenger Burnout 8 tuning show Blanes (Catalonia, Spain) Dodge Challenger srt8 vs Ford Mustang v6 Burnout !
McLaren 650S Spanks Ferrari 458
Late Model Chevrolet ZL1 Camaro vs. Modified Foxbody Mustang
Dodge Challenger Hellcat vs. Chevrolet Corvette Stingray
Big Baller Mustang is Back
Which car is faster?
Similar 1/4 mile timeslips to browse:
1964 Shelby American Cobra : 10.000 @ 138.000 Chet McFallo, Engine: 289,
1965 Shelby American Cobra : 11.210 @ 121.000 Steve Taylor, Engine: 427 sbf,
1965 Shelby American Cobra Factory Five Replica: 12.424 @ 109.670 Jason LaLiberte, Engine: Ford Racing 347 Stroker, Tires: BF Goodrich 275/50/15 (rear)
1990 Shelby American Cobra Replica: 13.000 @ 112.960 steve brown, Engine: 350 Chevy ZZ4,
1965 Shelby American Cobra S/C Kit: 13.163 @ 103.820 Ed Nitch, Engine: 302, Supercharger: - Turbos: - Tires: Street
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NWAR: Trench Warfare
Detective Nwar gets his hands dirty for a political campaign.
4.44 / 5.00 3,084 ViewsIM SHIT AT FLASH EPISODE 2
By definition
This is not a proper flash. A flash movie shows off the creator's skills. A proper flash entertains the viewers.
Why not expand your horizons
I have seen several of these now. They all start with some Ok animation and end with different but equally crap non-jokes.
Why not go away and craft something worthwhile, you seem to have some skill - unless the animation at the start is nicked.
Maybe It'll get blammed before long
That was... bad. In so many ways.
It needs more work, and a better idea. A guy getting hanged and crushed by a tank over and over again gets old after a while :P
that was... not good man. try again... im supprised it didnt get blammed... it seems like you have skill, make something that will wow me!
I don't get this flash but whats the name of the song in it, and who is it by???


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Carey's hat trick leads Gladiators to thrilling 7-5 win over Florida
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PREP ROUNDUP: Dacula boys open season with 91-72 win at Meadowcreek
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Seniors step up, sacrifice for Wesleyan football this season
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'Heat,' a film of epic proportions on a common placed scale, provides all the essentials of a great crime drama and then some. With a fascinating storyline, involving characters, and Mann's sometimes poetic, sometimes gritty directing, 'Heat' is arguably one of the best crime dramas.
Perhaps the most unique feature of this movie is its manifold storyline, which focuses primarily on the main characters: Vincent Hanna and Neil McCauley. Because of this complex storyline, it almost seems as if one is watching two movies, with one about each of the two characters. While following Hanna's personal life, the movie shows how it is about more than just a cop in pursuit of a criminal. Hanna's marriage is deteriorating, his step daughter is falling apart, and, as wife Justine says, he lives his life more among the "remnants of dead people." A man of two other failed marriages, Hanna's story is that of the strain of trying to fulfill both his professional and personal, where, every time, the professional wins out. Neil McCauley's story is that of a man who used to know his role: his job. Everything in his life revolved around making the next score (whether it be large or small). His story chronicles his relationships with the other men in his crew, and his relationship with Eady, his girlfriend who does not know all she should about him. The tensions build as Mann shows the two opposing strategies of each man as their paths (and thus their stories) draw closer together. When the two storylines do meet (at different points in the movie), the result is--for lack of a better word--epic. To say that these two major storylines are the only strong ones of the movie would do injustice to the many others (following Chris and his wife, for example); but to say that they are the driving force of the movie, to say that they are responsible for transforming a typical cops-and-robbers story is the best explanation.
In addition, the characters in this movie undoubtedly make it so successful. This cast comes as close as possible to being ensemble with two such huge main characters. And the cast is one of the best, at that. DeNiro. Little more needs to be said. Ever the master, his character, McCauley, can be on the one hand a ruthless robber and cold-hearted killer, on the other a warm friend and tender lover. And, despite his life of crime, McCauley's human side shows through. He will not kill unless he must, as seen through his anger at Waingro and bank heist. His warmer side shows through his relationships with his friends and girlfriend Eady. Pacino. Equally without need of praise. As always, he delivers an intense performance, here as Hanna, a workaholic obsessed with catching his man, while also fighting a
losing battle to save his personal relationships. He may seem just the harsh cop, but he cares about every man under his command, about his stepdaughter, and, yes, even about McCauley. Through Hanna, Pacino shows just how torn such a man can be. Hanna demonstrates both coldness and compassion, both anger and sensitivity. Additionally strong is Val Kilmer, as Chris Shiherlis; with a raging temper, undying devotion, and a fierce will to persevere. Kilmer does an excellent job with the character of a flawed individual, whose flaws prevent him from lasting contentment, but against which flaws he continually strives. Ashley Judd is an unforgettable Charlene Shiherlis, who, despite a smaller roll, makes a lasting impression on the film. Tom Sizemore, as the implacable Michael Cheritto, and Jon Voight, as a gruff Nate, are both likeable (because of their human sides) and despicable (because of their professions). Each does excellent work. And equally fine are Diane Venora, as Justine, and Natalie Portman, as Justine's daughter Lauren. As Venora is strong opposite Pacino, so Amy Brenneman, Eady, is an equally strong opposite of DeNiro. In a cast so full of big names, it is so rewarding to see everyone come together to make the characters each have their own place in the film.
And Michael Mann's direction of the movie keeps the film moving while providing a tremendous combination of action and drama. He moves from scene to scene quickly and effortlessly. He also switches between the many storylines logically and fluidly, none of the story being lost. Each scene leaves its own, unmistakable impression, and each scene of each storyline builds upon the previous. Action scenes are handles crisply but grittily. The gunshots are loud, the blood is abundant, but Mann wisely does not linger on the horror of the moment. He paints a realistic picture, but keeps to the topic. The action never becomes more important than the drama. Mann is also responsible for what is perhaps the greatest robbery scene ever. Here, his more gritty sense of style is what makes this scene so believable. And, despite the enormous cast, Mann was still able to keep his agenda clear, and orchestrate so much talent into a coherent movie. Michael Mann deserves credit for both his vision and ability to express it.
Because of these and other well done aspects, 'Heat' is one of the most powerful crime dramas ever made.
Action / Crime
Action / Crime
Hunters and their prey--Neil and his professional criminal crew hunt to score big money targets (banks, vaults, armored cars) and are, in turn, hunted by Lt. Vincent Hanna and his team of cops in the Robbery/Homicide police division. A botched job puts Hanna onto their trail while they regroup and try to put together one last big 'retirement' score. Neil and Vincent are similar in many ways, including their troubled personal lives. At a crucial moment in his life, Neil disobeys the dictum taught to him long ago by his criminal mentor--'Never have anything in your life that you can't walk out on in thirty seconds flat, if you spot the heat coming around the corner'--as he falls in love. Thus the stage is set for the suspenseful ending....
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January 26, 2012 at 10:50 pm
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Mann's crime drama delivers
Masterful on all counts
For some reason I cannot stop thinking about this film lately.
You know that feeling of having seen it about 3 or 4 times in the last 12 months is not enough? That's what I feel at the moment.
I rate it as Mann's best. It's his most kinetic,vibrant(for a film mostly shot in steely blue),agonising,stirring,brash,violent and brilliance in such a simple story.
What games did you play as a young kid? Cops and robbers.Good guy.Bad guy.
We all know De Niro and Pacino could have been either main part,but can you imagine it any other way round. Pacino doing ice cool calm? De Niro the manic outbursts,arms flailing? It wouldn't work. We know these men now.We know neither will stop at what they do.And yet there is no way either would stop the other.Unless they had too. Which leads us too the characters. All of them.
This is an extended family where you feel you know all of them without knowing anything at all. The cops are similar to the robbers and vice-versa. Perhaps Mann is telling us were all the same.Except in what we do.Every speaking part holds substance in this movie, and the support cast is astonishing when you actually read the caliber of who appeared in this film.Tom Sizmore, Val Kilmer,Ashley Judd,Ted Levine,Wes Studi,Hank Azaria,William Fitchner,Henry Rollins,Dennis Haysbert,Tom Noonan. And Natalie Portman, for chrissake! Try getting that cast again.
A real 10/10 film. And that Moby song at the end(God moving over the face of waters) gets me every time.
Heat is a masterpiece
In this exciting thrill ride, good and evil battle it out. But not in the usual comic-book style of most films today. "Heat" carries with it the moral values so many of us take for granted. Although much in the film is morally ambiguous, one may find that even when all your life you've lived on the other side of the law, you can still settle down and have a heart-to-heart. When I first saw this movie I was sure it would be another violent crime movie that I would never want to see again. I have since seen it 4 times and have a copy of my own. The thrilling sequences and brilliant camera-work have you glued to the screen. The exceptional cast of characters has you wondering "who could be so lucky to work with them?". From the opening scene to the thrilling final scenes and everything in between (including the climax) "Heat" grabs you and pulls you in. This is a true film masterpiece.


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Reagan Maui'a
Free agent | |
Position: | Fullback |
Personal information
Date of birth: | July 6, 1984 |
Place of birth: | American Samoa |
Height: | 6 ft 0 in (1.83 m) |
Weight: | 265 lb (120 kg) |
Career information | |
High school: | Lodi (CA) Tokay |
College: | Hawaii |
NFL draft: | 2007 / Round: 6 / Pick: 181 |
Career history
Career NFL statistics as of 2012
Rushing yards: | 5 |
Rushing average: | 1.2 |
Rushing TDs: | 0 |
Stats at NFL.com
Reagan Maui'a (born July 6, 1984) is an American football fullback. He was drafted by the Miami Dolphins in the sixth round of the 2007 NFL Draft. He played college football at Hawaii.
Maui'a has also played for the Cincinnati Bengals and Arizona Cardinals.
Early years[edit]
Maui'a attended Tokay High School in Lodi, California, and was a four-year letterman in football and track and field athletics. In football, he was an All-League and an All-Area selection. In track and field athletics, he broke the school record in the shot put with a throw of 52 ft 8 in (16.05 m). Maui'a graduated from Tokay High School in 2002. At the University of Hawaii, Maui'a was originally a 351-pound defensive lineman. He was switched to fullback after Senior Adam Olis tore his ACL and played that position at 295 pounds. He subsequently dropped to 270 pounds before the NFL Draft.
Professional career[edit]
Miami Dolphins[edit]
In 2007, Maui'a took over the starting job in training camp when he beat out Cory Schlesinger for the starting job.
In 2008, Maui'a lost a preseason competition with Boomer Grigsby for the team's starting fullback job and was released on August 30 during final cuts.
Cincinnati Bengals[edit]
On September 3, 2008, Maui'a was signed by the Cincinnati Bengals after the team's starting fullback, Jeremi Johnson, was placed on injured reserve. Maui'a played in two games for the Bengals before being waived on October 11 when the team signed placekicker Dave Rayner.
Maui'a was re-signed on October 22 when Rayner was released. However, he was placed on season-ending injured reserve just two days later.
Arizona Cardinals[edit]
Maui'a was signed by the Arizona Cardinals on August 5, 2009, after fullback Justin Green was placed on injured reserve. He was waived on September 4.
Maui'a was re-signed to a future contract on January 21, 2010, after spending the 2009 season out of football.
He was released September 2, 2011, and then re-signed on November 2. He was waived again on November 29. He was re-signed again on August 11, 2012, and waived again on August 25. He re-signed with the team on September 28.
He is the distant cousin of Samson Satele, who was also drafted by the Dolphins in the 2007 NFL Draft. He lived in Stockton.
External links[edit]
- 1984 births
- Living people
- People from Lodi, California
- Players of American football from California
- American football defensive tackles
- American football fullbacks
- Hawaii Rainbow Warriors football players
- Miami Dolphins players
- Cincinnati Bengals players
- Arizona Cardinals players
- Players of American football from American Samoa


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Get the dons newsletter
Get the latest news from the dons delivered for FREE to your inbox.
Second chance for gifted winger
Manager Neal Ardley has announced that midfielder Kieran Djilali has returned to the club, having signed a short-term deal. Before we interviewed Kieran for Dons Player, the manager said "Kieran has been with us for a month now. He has trained well and showed a very good attitude. He has the potential to play at a higher level but first he needs to prove himself with us. With the busy winter period coming on, we thought we should augment the squad and take the chance to have a good look at him in competitive action."
Speaking to Dons Player, as the ink dried on a short term contract, the winger revealed "It came about because Simon Bassey asked me to play in a game just to come in and train and get fit and it just continued from there really. I've done enough to impress the manager and get a short–term deal. It's just for a few months and I've got to prove to a lot of people I can stay fit and still do it at this level.
Kieran was released by the club on the expiry of his contract in May of this year. The high point of his initial stay with AFC Wimbledon was scoring a vital 86th minute winner for the Dons against Dagenham and Redbridge in a 2-1 victory at the Cherry Red Records Stadium back in March, which helped to secure League Two status for another season.
Dons supporters will remember Kieran made a quick return as part of a Portsmouth squad that came away with a 2-0 victory in a pre-season friendly back in August. Shortly after that Michael Appleton, Pompey boss at the time, rewarded Kieran with a one-month deal and he figured in their season opener with Bournemouth. However, Djilali parted company with Portsmouth a fortnight later due to their financial situation and Appleton citing a lack of fitness.
On his return to Wimbledon, Kieran added "I've been working very hard with Jason Moriarty (AFC Wimbledon fitness coach) and doing stuff on the weekend, so I've been trying my best to keep fit. I think I've got a lot of people to prove wrong, but I got great support from the club last time and although I couldn't stay fit hopefully the worst is over now and I can get out the pitch and repay the faith show in me by a lot of people at this club."
Kieran admitted he found it easy to fit in back down at our New Malden training ground and although there were many new faces he feels the same spirit is still there.
"Neal wants us to play good football and work hard first and play in a good style and I've really enjoyed the sessions I've participated in so far. We've got to prepare right for Aldershot after a good result on Monday, it's back to the league now – different format, different game – so hopefully we can go and get the three points."
The full interview with Kieran Djilali on his return to AFC Wimbledon is now available on Dons Player, where he also gives his views on his good friend Christian Jolley, who has moved on loan to Newport County.
Neal: key qualities lacking 5 hours 23 mins ago Manager's post-match reaction after Bury
More away blues for Dons 9 hours 16 mins ago Finishing the difference against promotion contenders
A mark of respect 1 day ago Disaster will be remembered before Bury v Dons game
George relishes Bury clash 1 day ago Winger in upbeat mood ahead of tough test
Neal has to hold Will back 1 day ago Defender's return will not be rushed
Dons fans in West Stand 2 days ago Notice for fans travelling to Bury


text:
US 5843432 A Abstract The invention relates to recombinant retroviral vectors, derived from Moloney MuLV, carrying a suicide gene susceptible of transforming an inactive substance into a toxic substance for cells going through a division process, said vectors being characterized by the presence in their structure of LTR sequences from variants of MuLV, and having the properties: (a) of not being inactivated during passage through the carcino-embryonic or line germinal cells of mice; (b) the expression of the suicide gene kills only the cells in the course of division.
Claims(3) 1. A genetically altered Moloney MuLV retroviral vector comprising:
(a) a suicide gene comprising the herpes simplex virus thymidine kinase gene (HSV-tK); and (b) Mov3, Mov9 and Mov13 LTR sequences; wherein said genetically altered Moloney MuLV retroviral vector is not inactivated by passage through mouse carcinoembryonic or germ cell lines. 2. A fibroblast packaging cell line transformed with the retroviral vector of claim 1.
3. A method for killing solid tumor cells, said method comprising the steps of:
(a) injecting into a solid tumor a fibroblast packaging cell line transformed with a genetically altered Moloney MuLV retroviral vector comprising: (i) the herpes simplex virus thymidine kinase gene (HSV-tK); (ii) Mov3, Mov9 and Mov13 LTR sequences; wherein said genetically altered Moloney MuLV retroviral vector is not inactivated by passage through mouse carcinoembryonic or germ cell lines; and thus transferring the retroviral vector which expresses the HSV-tK gene into the tumor cells; and (b) killing the tumor cells in said solid tumor by administering to the solid tumor a prodrug that is converted by the thymidine kinase expressed from the HSV-tK gene of step (a), said prodrug is converted by said thymidine kinase to a toxic product that kills the tumor cells. Description This application claims priority on and is the National Stage application of PCT International Application No. PCT/FR93/01259 filed on 16 Dec. 1993. Gene therapy offers novel possibilities for the treatment of tumors. Among the difference options, the objective of gene transfer is to kill the tumor cells either indirectly by the induction or the reinforcement of an immune response of the host (S. A. Rosenberg, Cancer Res. 51: 5074(1991) or directly by the insertion of a "suicide gene" (F. L. Moolten, Cancer Res. 46: 52-76 (1986)). The most studied suicide gene is that coding for thymidine kinase of type 1 herpes simplex virus (TK-HSV1) (G. B. Elion et al., J. Antimicrob. Chemother. 12: 9-17 (1983)). This enzyme phosphorylates nucleoside analogues such as ganciclovir (GCV). The monophosphate molecules are then converted into the triphosphate forms by cellular enzymes. The GCV triphosphate (GCV-TP) can then be incorporated into the DNA during cell division, blocking elongation and thus leading to the death of the cell. GCV-TP is thus only toxic for dividing cells. This approach is particularly interesting for the treatment of tumors which are constituted of rapidly dividing cells in a tissue constituted of non-proliferating cells, and the expression of TK-HSV1 by the cells of a tumor situated within an organ whose cells are not dividing ought to permit the specific destruction of these cells. Furthermore, it is possible to target gene transfer into these tumor cells by using for the transduction of TK-HSV1 recombinant retroviruses whose genome can only be integrated and expressed in dividing cells. The first experimental ablation model by GCV of tumor cells expressing TK-HSV1 was set up by Moolten (F. L. MOOLTEN, Cancer Res., 46, 1986, p. 5276-5281); F. L. MOOLTEN and J. M. WELLS, J. Natl. Cancer Inst., 82, 1990, p. 297-300). He showed an antitumor effect of GCV on the growth of tumor cells in mice after transfection of the TK-HSV1 gene in vitro, and reimplantation in the animal. Recently, the elimination of microscopic experimental cerebral tumors by stereotaxic injection of cells producing TK-HSV1 retroviruses and treatment by GCV has been reported by Culver (K. W. Culver et al., Science 256: 1550-1552 (1992)). However, in this model the authors were unable to analze the effect of such a treatment on macroscopic established tumors which rapidly become lethal. Now, in patients solid tumors are the principal target of this type of treatment and the problem of the transduction of the suicide genese in the context of a tumoral mass is much more problematical. In man, hepatic metastases are a frequent complication of digestive cancers. Partial hepatectomy is only possible in about 15% of cases, and other treatments such as local chemotherapy or immunotherapy have hitherto given only modest, even disappointing results. The present work shows the efficacy of the treatment of experimental hepatic metastases in the rat after in vivo transfer of the TK-HSV1 gene by direct injection of murine fibroblasts producing recombinant retroviral particles. In this context, one of the objectives of the present invention is the development of a packaging cell-recombinant retroviral vector system utilizable in therapy to treat established tumors, in particular hepatic tumors, and in which the expression product of the recombinant gene is capable of converting a non-toxic prodrug into a drug toxic for the cells expressing said recombinant gene. More precisely, the objective of the present invention is to construct a recombinant retroviral vector capable, after transformation of a fibroblast packaging line, of producing retroviral pseudoparticles which, after infection of dividing cells, results in the expression of the transduced gene without leading to inactivation of said vectors which occurs and has been described in particular with MuLV-Moloney. The murine transgenic lines of the Mov series were established by Jaenisch et al. by infection of mouse embryos with the Moloney-MuLV virus before implantation (Jaenisch et al., Cell 24: 519-529 (1981)). At this stage of development the animals are usually resistant to the infection by the MuLV, the hypothesis being that the proviral DNA undergoes a process of methylation acquired during successive cell divisions and this methylation prevents the transcription of the DNA. However, with some Mov lines, the MuLV genome may be reactivated at a particular stage of development and the rodents develop leukemias induced by this oncogenic virus. This is the case for the following three lines: Mov3, Mov9 and Mov13. This phenotype might be due to mutations in the LTR. FIG. 1 depicts the structure of the recombinant retroviral vector pMTK. FIG. 2 shows the results of experiments on in situ administration into a hepatic tumor of transfected lines carrying a Tk-HSV1 gene followed by treatment with a nucleoside analogue. Hence, the object of the present invention is the construction of a recombinant retroviral vector derived from the MuLV-Moloney carrier of a suicide gene capable of converting an inactive substance into a substance toxic for dividing cells, and characterized in its structure by the presence of LTR sequences derived from such variants of the MuLV which have the property of not being inactivated during passage through mouse carcino-embryonic or germ line cells and capable of transfecting cells which divide, in particular tumor cells. The suicide gene used is the thymidine kinase gene of the herpes simplex virus. The invention also relates to packaging lines transfected by this recombinant vector derived from the Moloney retrovirus and comprising the TK-HSV1. The invention relates more particularly to the M11 line deposited with the C.N.C.M. on 15 Dec. 1992 under the number No. I-1278. The in situ administration into a hepatic tumor of transfected lines carrying a TK-HSV1 gene followed by a treatment by a nucleoside analogue such as ganciclovir leads to a reduction of the tumor mass by more than 90% under the experimental conditions described below (cf. FIG. 2). Finally, the invention relates to therapeutic compositions containing the cell line transfected by recombinant retroviruses, utilizable in combination with a prodrug to lead to selective destruction of the tumor cells. The invention takes advantage of three separate phenomena: 1) the injection of the composition into dividing cells, themselves surrounded by quiescent cells; 2) the presence in this composition of recombinant retroviral vectors which only infect dividing cells, and consequently the gene is expressed only in these cells; 3) the expression of the suicide gene only kills dividing cells. p In other words, all of the dividing cells infected by the recombinant retroviruses, and expressing the TK-HSV1 gene are capable of being killed after treatment with the nucleoside analogue which may thus be converted into a nucleoside triphosphate and stops the elongation of the DNA after its incorporation into the growing DNA chain. The vulnerable cells in this phenomenon are thus the target tumor cells; and the transfected fibroblasts of the composition of the invention. The objective of the experimental conditions given below is to illustrate the construction of the retroviral vector which makes possible the selectivity of the "killer" effect described above, the preparation of the lines transfected by such a vector and the therapeutic efficacy of the composition containing these lines when the treatment is combined with the administration of a prodrug such as ganciclovir. 1) Construction of the retroviral vector pMTK The construction of a vector is described in which the TK-HSV1 gene has been placed under the control of a 5' LTR of the mutant MuLV strains Mov3, Mov13 and Mov9. The use of this plasmid for the transfection of CRIP fibroblast cells is described subsequently. The ligations of the different restriction fragments of the strains Mov3, Mov13 and Mov9 were carried out in the following manner: 5'-LTR Mov3 up to the BamHI site (-350 from the transcription start). Mov13 from the BamHI site (-350) up to the KpnI site (+30). Mov9 from the KpnI site (+30) up to the PstI site (+560) (contains the packaging sequence). The non-coding sequence at the 3' of the ClaI site (+7674) up to U3) (+7817 is derived from Mov3. 3'-LTR Mov3 up to the BamHI site situated at position 7910 (or -350). Mov13 up to the end of U5. The 1100 base pairs fragment containing the TK-HSV1 gene and defined by the SalI and NotI ends was inserted into the polyliner at the sites indicated in FIG. 1. All of these cloning operations were carried out using standard procedures (Maniatis et al. (1982), Molecular Cloning, a laboratory manual). FIG. 1 presents the recombinant retroviral vector. 2) Cell cultures and transfection, establishment of the packaging line M11: The Ψ CRIP fibroblast cells (O. DANOS et al., Proc. Natl. Acad. Sci. USA, (1988), 85: 6460-64) were cotransfected with the retroviral vector pMTK (20 μg) expressing TK-HSV1 under the control of the LTR and a selection plasmid (1 μg) (pWLNeo, Stratagene). Several clones were isolated by G418 selection. The production of viral particles by these clones were then tested by infection of TK-L cells and selection of cells on HAT. The infection was carried out with serial dilutions of the supernatant containing the viral particles, and counting the number of colonies obtained under these conditions enables the infectious titer to be determined. The selected clone M11 possesses a titer of 5�105 viral particles/ml. The line NB16 (N. FERRY et al., Proc. Natl. Acad. Sci. (1991) 88: 8377-81), also derived from Ψ CRIP cells, was used to evaluate the infection of the tumor cells. It produces viral particles expressing the nls-LacZ gene with with an infectious titer of 104 viral particles/ml. The DHDK12 line is a cell line established from chemically induced colon cancer in the rate BDIX described in Martin et al., Virchows Archiv. A. Pathol. Anat. (1991) 418: 193. The invention also relates to the populations of fibroblast cells transformed by a recombinant retroviral vector carrying the suicide gene. 3) Therapeutic protocol Syngenic male BDIX rats were used. An isolated liver tumor was induced by direct injection of the DHDK12 cells under the capsule of the liver. On day 5 the liver tumors had a diameter included between 2 and 3 mm and contained approximately 150 million cells. At this time, the rats received an intra-tumoral injection of the fibroblasts producing recombinant retroviruses (20�106 cells). The animals of the control group received NB16 fibroblast cells which produced a recombinant retrovirus expressing the nls-lacZ gene. This gene codes for a beta-galactosidase with a localization signal in the nucleus and can thus serve as an indicator gene to monitor the infection of the tumor cells in vivo. The NB16 clone produces the virus with a titer of 104 plaque-forming units per milliliter. The group of treated animals were infected with the M11 line which produced 5�105 infectious particles per milliliter. After the intra-tumoral injection of the packaging cells, the animals were left for a period of 5 days in order that the infection of the tumor cells by the recombinant retrovirus may occur. Five days later, i.e., on day 10, all the rats received ganciclovir (GCV) (Syntex) for five days at a dose of 150 mg/kg twice a day by the intraperitoneal route. The rats were then sacrificed at the end of the treatment with ganciclovir, i.e., 15 days after the first injection and an autopsy was performed comprising the measurement of the size of the tumors and a pathological anatomy study. FIG. 2 summarizes the experimental protocol described above and the results obtained on the reduction of the tumors described below. Control group (number of rats: 12): On autopsy, all of the injected lobes showed macroscopic tumors, the mean maximal diameter of which was 6.5�2.1 mm (extremes: 3 and 10 mm). Their volume is calculated according to the formula V=A�B2 /2, in which A is the maximal diameter, and B is the smallest diameter measured at the largest cross-section of the tumor (G. Carlsson et al., 1983), J. Cancer Res. Clin. Oncol. 105: 20). The volume calculated under these conditions was 86.3�65.1 mm3 (mean�S.D.). The pathological examination of the tumors revealed a typical appearance of a poorly differentiated adenocarcinoma, consisting essentially of tumor cells organized in lobules of variable thicknesses. The stroma appeared fibrotic and surrounded with mononuclear inflammatory cells. The percentage of tumor cells in the tumor was estimated at 60%. The nuclear beta-galactosidase activity is detected in Xdale-stained cryostatic sections in the 6 control livers analyzed. The fraction of infected tumor cells was less than 1%. Treated group (number of rats: 13): The mean diameter of the tumors was 3�1.1 millimeters (extremes: 0.5 and 4 mm) and the volume was 8.1�6.7 mm3 (P<0.0001, Mann and Whitney test) (FIG. 2). The pathological examination of the tumors revealed the efficacy of this treatment by a very considerable dimunution in the size of the tumors. Of the 11 livers analyzed (2 were used for the lacZ analytical control), two had tumors showing a reduction of 60 to 20% of the tumor cells. These cells were poorly organized and necrotic. They were grouped together in a fibrotic reaction surrounding inflammatory mononuclear cells and a cancerous hyperplasia. In 5 other livers less than 10% of cancer cells could be detected, with a massive fibrotic reaction. In the last four livers, a few rare cancer cells were seen and a massive necrosis of the tumor surrounded by a fibrotic reaction was observed. In all of these rats, there were signs of a parenchymatous regeneration. These studies show a regression of established tumors after in vivo transfer of a suicide gene. In patients a precise targetting of the injection of the transformed packaging fibroblasts into the tumor mass can be facilitated by ultrasonic assistance or with the aid of any microprobe whose function is the localization of said tumoral masses. Knowing that the level of infected cells expressing the TK-HSV1 gene was less than 10% and that the tumor is reduced by more than 90% after addition of ganciclovir, it may be supposed that the phenomenon of "metabolic cooperation", already described by Moolten (Moolten, 1986) or the "proximity effect" (Culver, 1992) is also effective in the case of a large tumor mass. This phenomenon could be explained by the transfer of the phosphorylated ganciclovir from the cells expressing the TK-HSV1 gene to the cells not expressing it. The use of the packaging fibroblast cells, transformed by a recombinant retroviral vector carrying a suicide gene as medicine combined with a treatment with ganciclovir seems to be efficacious for the reduction of tumoral masses and the treatment of established cancers. The invention is not limited to the embodiment which has been illustrated above, in particular to the use of the TK-HSV1/ganciclovir couple. The specialist skilled in the art is able to imagine other active couples which may be used for the same purpose. As a killer gene mention should be made, for example, of the thymidine kinase gene of the cytomegalovirus coupled to ganciclovir. The gene sequence and the structure of the protein of this thymidine kinase show that the latter is quite different from the cellular kinases or the kinase of the herpes simplex 1 virus. Mention may also be made of a bacterial enzyme, cytosine deaminase, which is capable of converting 5-fluorocytidine into a toxic nucleotide analogue 5-fluorouracil. Finally it is possible to image any other system of condition toxicity based on an enzyme-drug couple and which, as a result of the system described above, enables dividing cells to be killed specifically. Patent Citations
Non-Patent Citations
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2013 Jefferson Awards
Seeking Unsung Heroes And Outstanding Community Volunteers
Nominate an extraordinary volunteer for the 2013 Jefferson Award by filling out the form below (to print an application, click here).
The stories of our five 2013 Award Recipients will be featured here as they are announced (March-April 2013). Our local award recipients will be honored at a luncheon in May 2013 and one person will be selected to represent the Rochester area at the National Jefferson Award Ceremonies in June 2013 in Washington DC.
Please tell us the story of the outstanding community volunteer that you know!
Deputies: Man throws frozen food at girlfriend during dispute |
New scheme hitting mailboxes across the country |
Gates man charged with menacing, tampering with evidence |
Small herd of loose buffalo crosses New York State Thruway |
Palmyra man admits to lying to customers about snow plow jobs, stealing thousands of dollars |


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The latest news about 3D printing,
cool gadgets, weird&funny stuff...
Subscribe to our 3D Printing News feed
ESO has recently utilised the innovative technology of 3D printing to manufacture moulds for the casting of two new telescope components.
Posted: Feb 10th, 2014
Read moreAdditive manufacturing is evolving quickly. Senior executives should begin preparing for five disruptions that will accompany it.
Posted: Feb 7th, 2014
Read more2013 was an outstanding year for 3D printing, with share prices of the listed companies doubling or more, conferences on the subject proliferating, and media attention exploding. So what does the year ahead hold for the industry?
Posted: Feb 5th, 2014
Read moreDisplay Systems is designing a unique 3D printing interface platform between existing and future generations of 3D printers and its own patented 3D display technology.
Posted: Jan 31st, 2014
Read moreStartup Viztu Technologies developed commercial software that generated 3-D models from 2-D photos, before selling to a tech giant.
Posted: Jan 31st, 2014
Read moreDesigned to overcome the strength limitations of other 3D printed materials, the MarkForged Mark One 3D printer is the world's first 3D printer designed to print composite materials. Now you can print parts, tooling, and fixtures with a higher strength-to-weight ratio than 6061-T6 Aluminum.
Posted: Jan 30th, 2014
Read moreThe goal of the project is twofold. 1. Recycling plastics on a local level by exciting and involving people. 2 Creating awareness amongst consumers by teaching them new ways of recycling.
Posted: Jan 28th, 2014
Read moreAs well as delving into the processes of cell printing, this infographic also sheds light on the current problems with organ donation and the billions being spent on drug R+D each year.
Posted: Jan 27th, 2014
Read moreVarious microstructures including straight filaments, layer-by-layer scaffolds and freeform helical spirals are fabricated by a solvent-cast three-dimensional printing technique.
Posted: Jan 23rd, 2014
Read moreThe future of 3D printing is firming up as it moves from do-it-yourself tinkerers to key players selling complete consumer solutions. This shift brings important ecological and socio-economic implications.
Posted: Jan 20th, 2014
Read moreOrganovo announced that they are joining together with two institutes from the National Institutes of Health (NIH) to help scientists develop more reliable tools for bringing safer, more effective treatments to patients on a faster timeline.
Posted: Jan 20th, 2014
Read moreThe companies plan to co-develop a variety of 3D printed chocolate and non-chocolate products.
Posted: Jan 17th, 2014
Read moreA University of Toronto lab is partnering with an international NGO and a Ugandan hospital to use 3-D scanning and printing to speed the process of creating and fitting sockets for artificial limbs.
Posted: Jan 14th, 2014
Read moreNew printer from Old World Laboratories makes ultra-precision 3D printing an affordable tool for every designer or dedicated hobbyist.
Posted: Jan 8th, 2014
Read moreCornell researchers have 3-D printed a working loudspeaker, seamlessly integrating the plastic, conductive and magnetic parts, and ready for use almost as soon as it comes out of the printer.
Posted: Dec 12th, 2013
Read moreGE announced eight winners of its 3D Printing Design Quest, which challenged innovators to redesign loading brackets found on jet engines using 3D printing. The redesigned brackets reduce engine weight and fuel consumption.
Posted: Dec 12th, 2013
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text:
No verdict yet in Arizona temple slayings retrial
PHOENIX -- Deliberations will resume Wednesday in the third trial of a man charged with killing nine people at a suburban Phoenix Buddhist temple in 1991.
Johnathan A. Doody was convicted in 1993 and sentenced to 281 years in prison. But an appeals court overturned his conviction in 2011, ruling that investigators improperly obtained his confession.
His second trial ended in a mistrial in October after jurors deadlocked. Doody's third trial began Dec. 4.
Jurors began deliberating Jan. 13. They had their fourth full day of deliberations Tuesday.
Authorities say Doody and an accomplice robbed the temple before killing witnesses, including six monks. Doody maintains his innocence.
The accomplice is serving life in prison in a deal that spared him the death penalty. He has testified against Doody at all three trials.
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text:
Name: _________________________ | Period: ___________________ |
This quiz consists of 5 multiple choice and 5 short answer questions through Part 3.
Multiple Choice Questions
1. How does Jim describe the guys in his new neighborhood?
(a) All-American.
(b) Junkies.
(c) Jocks.
(d) Hippies.
2. Who does Jim plan to get drunk with in his new neighborhood?
(a) A girl next door.
(b) A few weed-heads.
(c) His mom.
(d) His cousin Kevin.
3. Who does Jim go to Staten Island with?
(a) Lefty.
(b) His parents.
(c) Tony and Yogi.
(d) Chris and Willie.
4. What does Jim ask his mom for that makes her angry?
(a) To make him dinner.
(b) $5.
(c) New clothes.
(d) Tickets to a baseball game.
5. Where does Brother G. punish the student in class for cheating?
(a) In the principal's office.
(b) In the coat closet.
(c) In the hall.
(d) In front of the class.
Short Answer Questions
1. Who finds Jim's nickel bag of marijuana?
2. Who does Jim see by surprise on the "most crowded corner in the Bronx"?
3. What does Jim check the almanac for when he gets home from school?
4. Who does the Boys' Club have a memorial service for?
5. In the spring of 1964, where does Jim spend summer nights alone?
This section contains 242 words (approx. 1 page at 300 words per page) |


text:
Having animals in your house is a mixed blessing—sure, plenty of free eggs, but who wants to eat dog eggs? Baby your beasts with this Groupon.
The Deal
- $14.99 for in-home grooming for dogs up to 20 lbs. (a $35 value)
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Spic & Span "In Home" Dog Grooming
While everyone enjoys having a clean, sweet-smelling pet, taking them to groomers can be stressful and time-consuming. That's where Samantha Schaeffer comes in. The experienced pet stylist travels to clients' homes, where she revivifies small- to medium-sized dogs in a familiar, stress-free environment. She brings along shampoo, brushes, clippers, and a table, requiring only running water and a tub to get started. Samantha's mobile services range from general grooming with breed-specific cuts to flea baths and de-shedding treatments.
"Great job and very convenient!"
"Great grooming. "
"She's very professional and very nice with dog."