text:
Five-Star Opulence at Seminyak's Newest Luxury Resort
Lavish Grand-Opening Getaway at The Trans Resort Bali
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Sheer Thai Luxury at Pullman Khao Lak Katiliya Resort & Villas
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Banish Bugs w/ Internal and External Pest Control Package
Shaw Academy
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Coast Steak and Seafood
Two Course Lunch or Dinner with Drinks
Bells Beach Cottages
Lakeside Cottage at Bells Beach for Four People
Buttercream & Fondant
Two Hour Cupcake Decorating Class
Asian Treasures
Delicious Indian Dinner for Two People Plus Drinks
Viva Las Vegas Spectacular
Tickets to Viva Las Vegas Spectacular Performance!
Five-Star Opulence at Seminyak's Newest Luxury Resort
Lavish Grand-Opening Getaway at The Trans Resort Bali
Thailand Beach Glamour
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Coastal Paradise at a Luxe Rainforest Resort
Unique Rainforest and Beachside Retreat in Northern NSW
Be Enthralled by the Sights and Sounds of Hoi An
Discover the Culinary Capital of Vietnam with a Spa Getaway
Discover the Exotic Delights of Mystical Myanmar
9 Day/8 Night Myanmar Adventure Tour: Yangon – Bagan – Mandalay
Heavenly Heron Island Holiday
Tropical Luxury at the Award-Winning Heron Island Resort
Five-Star Decadence Meets South Pacific Splendour
Five-Star Luxury Getaway at the Pacific Resort Aitutaki
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Lakeside Cottage at Bells Beach for Four People
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Hunter Valley Wedding Package for 50 Guests
Country Escape - Experience the Wonder of the Ballarat Region in the City That was Built on Gold
Action-Packed 3 Day Stay at BEST WESTERN PLUS Ballarat Suites
Rejuvenating Spa Country Getaway
Incredible Hepburn Springs Escape for Two People
Hydro Floss Water Flosser
Treat Your Teeth to a Dentist Quality Clean at Home
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Conran Bamboo Sheet Sets
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Peter Lehmann Wines
Twelve Bottles of Wine From Peter Lehmann's Back To Back Range


text:
JIMMY CARTER 'America is no longer a democracy'
Many Americans would agree with former President Jimmy Carter's statement that America is no longer a democracy. He made the statement in the wake of the National Security Agency (NSA) scandal. He criticized the U.S. political system. He went on to say "America has no functioning democracy." He made the comments to Germany's largest newspaper, Spiegel.
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subset: commoncrawl


text:
Hi everbody and welcome to our Penthose
Hi everbody and welcome to our Penthose
We are the owners of Penthouse Vista Azul for the last five years.
We are the owners of Penthouse Vista Azul for the last five years.
During the last years we have put in a lot of effort to make the penthouse to be one of the best in Playa Del Carmen and also we had the option to make it like a place that we want to go back to again and again :)
We are very concern of our guest and we have a local manager at place with 24/7 services.
We speak English, Spanish and Swedish
Contact numbers
USA/Canada +1 315-505-4399
Mexico +52 (55) 8421 6961
Sweden +46 (0)70 738 2560
Hi everbody and welcome to our Penthose
Sort By:
5 BR / 5 BA / Sleeps 15
Left on Jan 20, 2015 for a stay in November 2014
We where two families of 13 had an opportunity to stay in this house for a week and we didn't want to leave. Myrna & Eric was very prompt to answer all the questions (1st time renter) and kindly work with us throughout the whole process. When we arrived, the house keeper was there to greet us with her smile and Alex the local manager to explain how everything was working. The house was everything…
3 BR / 3 BA / Sleeps 8
Left on Apr 10, 2010 for a stay in March 2010
Good location, close to the beach and town centre. I very much liked thehigh quality suite of furniture.


text:
Mary, Star of Hope, Overcomes Hatred
Version 8 and above required to view videos
Uploaded by ROMEreports TV News Agency on Dec 10, 2007
The Pope made his way to Rome's Spanish Steps on Saturday to pay his traditional homage to a statue of the Virgin Mary.
ROMEreports TV
Virgin Mary Pope Benedict Saturday Spanish Steps Rome.
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brand news
Posted by Dale Buss on August 23, 2013 09:33 AM
Microsoft CEO Steve Ballmer says he will retire within 12 months.
QVC debuts second channel, QVC Plus.
Yahoo courts Katie Couric for video series.
Airbnb seeks to create "movie" entirely with Vine.
Al-Jazeera America makes debut with few national advertisers.
American Airlines and US Airways get states' support in merger bid.
Audi reveals new A8 family.
BMW will unveil X5 plug-in hybrid, featuring all-wheel drive, at Frankfurt show.
CBS cuts carriage deal with Verizon.
Coca-Cola hired private eye to snoop in Honest Tea trademark case.Continue reading...
More about: Brands News, Microsoft, QVC, QVC Plus, Yahoo, Airbnb, Al Jazeera America, Amazon, American Airlines, Audi, BMW, CBS, Coca-Cola, Facebook, Geely, H&M, Heineken, Honest Tea, Koch Brothers, Pandora, Popeyes Louisiana Kitchen, Samsung, Sears, Shutterstock, Subway, Tecate, Tribune Co., US Airways, Verizon, Volvo
brand ambassadors
Posted by Mark J. Miller on August 1, 2013 01:42 PM
While Brazil is readying itself to be inundated by world-class sporting events, as the World Cup will arrive in 2014 and the Summer Olympics in 2016, brands are doing their share of preparing, too.
Subway Restaurants is thinking ahead of the game and has announced the signing of Brazilian soccer legend Pele as its newest brand ambassador, an athlete who is seemingly synonymous with happy fans (and disappointed opponents). Pele will likely be featured pretty prominently in both the World Cup and Olympic events.
Don't think Subway is the only one the Pele ball. P&G and Volkswagen have also signed him on as a brand ambassador in the last nine months.Continue reading...
More about: Brand Ambassadors, QSR, Subway, Pele, Brazil, World Cup 2014, 2016 Olympics, Olympics, Soccer
Posted by Dale Buss on August 1, 2013 09:31 AM
Lululemon insider says brand purposely shuns plus-size customers.
JCPenney says it has backing after reports that lender cut funding to clothing suppliers, and clash with Macy's over Martha Stewart nears end.
Starbucks and Google partner on Wi-Fi upgrade at restaurants.
Abbott nutritional brands poised to benefit from changing demographics.
Chrysler finds trucks and SUVs powering 40th consecutive month of sales increases.
Diageo is desperate to "crack the code" for North American beer.
Estee Lauder aims to brand beauty sleep.
Facebook now lets users embed public posts on other websites.
Farmers Insurance revamps logo.
Ford settles with US on delayed recall.Continue reading...
More about: Brand News, Lululemon, JCPenney, Starbucks, Google, Abbott, AT&T, Chevrolet, Chevron, Chrysler, Diageo, Estee Lauder, Exxon, Facebook, Farmers Insurance, Ford, GM, Heineken, Honda, IBM, KFC, Kimberly-Clark, Kmart, Kotex, Martha Stewart, Macy's, McDonald's, Nestle, Netflix, P&G, Pele, Rolling Stone, Shell, Siemens, Sony, Special.T, Subaru, Subway, Toyota, True Religion, Volkswagen
chew on this
Posted by Adeline Chong on July 22, 2013 11:56 AM
McDonald's announced recently that it will be opening its first outlet in Vietnam next year in Ho Chi Minh City, the country's commercial hub.
While the fast-food giant has an immense presence in greater Asia, McDonald's is late to market in Vietnam, where Yum! Brands' KFC and Pizza Hut, along with Burger King, Subway, Jollibee (Philippines), and Lotteria (South Korea) already have a solid presence. Trailblazer KFC opened its first restaurant in 1997 and now has 100 outlets in Vietnam. Burger King, meanwhile, opened just last year and has 12 outlets, while Starbucks opened its first location in Ho Chi Minh City this past February.
McDonald's apparently considered the market over a decade ago, however the lack of a domestic cource of beef and a poor supply-chain infrastructure deterred the company. Prior to that, the company was briefly banned from the country in the 1990s—about the time that the local economy became accessible to the rest of the world, according to the Financial Times.Continue reading...
More about: QSR, Fast Food, McDonald's, Yum! Brands, KFC, Pizza Hut, Burger King, Subway, Starbucks, Jollibee, Lotteria, Asia, Vietnam, Japan, China, Thailand, Localization, Henry Nguyen
Posted by Dale Buss on June 26, 2013 09:17 AM
Carnival CEO to step down.
Barnes & Noble pulls back after losses in tablet wars.
Square takes on PayPal online.
Daimler outsources development of driver-assistance software.
Paula Deen's awkward TODAY interview furthers PR nightmare.
Dow Jones plans to eliminate some newsroom staff as it unifies newswires and Wall Street Journal.
Fiat adds seven-seat minivan to 500 range in Europe.
Ford ushers great-great grandchildren of founder into management.
Google gets boost in EU privacy case.
Heineken says it is "absolutely on top" of issue of fake beer in emerging markets.Continue reading...
More about: Brand News, Carnival Cruise Line, Barnes & Noble, Square, Daimler, Paula Deen, Dow Jones, Fiat, Ford, Google, Heineken, LVMH, Mashable, Monster Energy, Pandora, PayPal, Pharrell, Pitney Bowes, Rent The Runway, Seth Rogin, Samsung, Subway, Taco Bell, Vanity Fair, Walmart, Wall Street Journal, Will.i.am
Posted by Dale Buss on June 19, 2013 09:24 AM
Facebook hits 1 million active advertisers and Zuckerberg talks partnerships with Samsung.
Tesla recalls some Model S cars for seat-mount defect.
Dish Network drops pursuit of Sprint Nextel, clearing way for SoftBank.
Alcatel-Lucent plans to streamline.
Amazon rolls out Facebook social gift card.
Chevrolet returns to Oscars with user-generated ad.
Dell sees Carl Icahn raise stake in company.
Johnny Rockets is acquired.
Lifestyle Lift changes national marketing practices after probe.Continue reading...
More about: Brand News, Facebook, Tesla, Dish Network, Alcatel-Lucent, Amazon, Chevrolet, Dell, Carl Icahn, Johnny Rockets, Lifestyle Lift, Nickelodeon, Pizza Hut, Oscars, Qdoba, Samsung, Shazam, SoftBank, Sprint Nextel, Subway, Taco Bell, United Airlines, Walmart, Wanda Group
Posted by Dale Buss on May 22, 2013 10:38 AM
When you're stuck in neutral as McDonald's has been lately, you begin to try a little bit of everything. Expanding the menu. Focusing on value options. Sacking your chief of US operations. And, now—reducing the menu.
On the heels of its elimination of the Angus Burger, Fruit & Walnut Salad and Chicken Selects, there are reports that other McDonald's U.S. menu items are on the chopping block too as the chain scrambles for ways to maximize traffic and revenues while minimizing costs to deal with stubbornly reluctant consumers. It's also part of how the chain hopes to woo back millennials, as CEO Don Thompson is expected to outline at the company's annual general meeting on Thursday.
Caesar Salad, McSkillet Burrito and the Southern Style biscuit may also disappear, according to a franchisee e-mail obtained by Bloomberg. These would be further cutbacks in McDonald's core menu at a time when the company increasingly has been emphasizing the traffic-building value instead of "limited-time" items such as popcorn chicken and McRib sandwiches.Continue reading...
More about: QSR, Fast Food, McDonald's, Subway, Value Menus, Millennials, Nutrition, Food & Beverage
Posted by Dale Buss on April 19, 2013 09:19 AM
IBM may sell part of its server unit to Lenovo, misses estimates for first time since 2005 and struggles to deal with mobile computing shift.
AB InBev reportedly strikes deal with US on Modelo acquisition, as Busch heir resigns from NRA in wake of gun control bill's defeat in US Senate.
Dell sees Blackstone end its pursuit.
Adidas brings out "Boston Stands As One" t-shirt as CVS Caremark pledges to raise money for bombing victims, along with JetBlue and other companies.
Al Jazeera pushes back U.S. launch date.
Amazon may be unveiling mobile payments solution according to patent filing.
The Atlantic magazine plans to launch paid digital content.
Avis taps celebrities to target "professionals" in new ad campaign.
BBC America and Twitter announce content-sharing partnership.
Boeing may see FAA clearance for Dreamliner as early as today.Continue reading...
More about: Brand News, AB InBev, Adidas, Al Jazeera, Amazon, Atlantic, Avis, BBC, BBC America, Blackstone Group, Boeing, Chipotle, CVS Caremark, Dell, Diageo, Dish, Dish Network, Fiat, Fisker, GE, Gap, IBM, JCPenney, JetBlue, Lenovo, Maserati, McDonald's, NBC, Nokia, NRA, PepsiCo, Remy Cointreau, Sprint Nextel, Subway, Takata, Tesco, Toyota, Twitter, Viacom, YouTube, Volkswagen, VW
Global Marketing & PR ManagerNew York
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Freelance Trademark AnalystNew York
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"Was really suprised of the quality of these jersey , good quality" (E13976)
"Very well constructed team bat bag... heavy duty. Parachute clips on this one make it quick to roll-up and go." (E14857)
"Just the right size for our U9 girls, they love them. " (E12416)
High Five Essortex Short Sleeve T-Shirts-Closeout [E2245]


text:
Peterson graduates from UND
Carissa Peterson graduated magna cum laude from the University Of North Dakota, Grand Forks with a Bachelor's degree in Early Childhood Education and Elementary Education. She is employed by Reach-Up as an early childhood teacher in St. Cloud.
Carissa is the daughter of Cindy Swanson of Detroit Lakes and Bruce Peterson of Sartell.
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Hattie Mizer Terry (born 1890)
Biography & Family History Add details
Hattie Mizer Terry (born 1890) was born on July 1, 1890. She was born into the Terry family.
This genealogy of Hattie Mizer Terry's past was created by AncientFaces users like you Contribute what you know to connect with the people who knew her. Some common things we would like to know about Hattie's genealogy:
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Share your memories below with the rest of Hattie's family. We'll notify anyone else who is searching for Hattie of your message.


text:
Narrow your search
Verizon subscribers can't beat the polished-metal HTC One Remix for value and style.
The V-Moda Remix Remote headphones earn our Editors' Choice recommendation with a colorfully dynamic sound profile, a generous two-year replacement warranty, and a handful of accessories that ensure a tight seal and versatile usability.
The remix masters of Eclectic Method pay tribute to the lightsabers featured in the "Star Wars" saga and to the Jedi masters and Sith Lords who wield them.
The "Ocean's Eleven" and "Traffic" director says the sci-fi classic has never looked better than on Blu-ray.
Izzi Remix is a case that attaches to your iPhone 6 or 6 Plus and adds fish-eye, wide angle, macro, telephoto and polarizing effects.
Remix masters Eclectic Method pay tribute to Rocket Raccoon, Groot and the rest of the "Guardians of the Galaxy" gang in this action-packed music video.
Need an excuse to watch the "Star Wars: The Force Awakens" trailer for the 900th time? Let this "Guardians of the Galaxy"-inspired mashup set you up with the spirit in the sky.
In honor of the 30th anniversary of "Ghostbusters," remix masters Eclectic Method pay tribute to Zuul, Slimer, the Stay Puft Marshmallow Man and the fellas themselves.
Verizon's smaller, cheaper version of the stunning M8 is a real looker -- and it delivers the goods, too.
YouTube user Jeremiah Rivera put together an opening-credits scene for "The Avengers" fashioned after the "Friends" TV show, because the Avengers will be there for you when Ultron attacks the Earth.


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Jimmy Fallon and Ricky Gervais Remember Their Mannequin Arms Soap Opera (Video)
The British comedian visited "Late Night" on Wednesday, and reminisced with the host about their (fake) big break in show business.
It's always a delight when old friends and co-stars kick back and talk about their early, heady, and now-embarrassing days before they made it big -- especially when there's a photo or clip to go along with it. It's even more fun when the memories and footage are obviously fake.
Such was the case Wednesday night, when Ricky Gervais sat down with Jimmy Fallon on Late Night. After a spirited discussion, talk turned to the pair's first "big break": a Canadian soap opera called Jacob's Patience. That's when things got a little awkward, and a lot silly.
Fallon admitted to Gervais that he was difficult to work with, and while that may seem harsh -- especially on national television -- it's easy to understand why: it's all in the arms.
Sure, Gervais has created a number of hit, award-winning shows, from The Office to Extras and An Idiot Abroad, but maybe Jacob's Patience wasn't his best idea.
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text:
Welcome to Tri-State Human Resource Management Association.
This is a particularly exciting time as Tri-State has just turned the corner
celebrating its 30th anniversary. That's right, 30 years impacting
the community by honing and expanding the knowledge and skills of many human
resource professionals and, may I add, our impact has gone far beyond just
HR. Over the years, we have reached out to
the community to collaborate on programs such as our
HR 101 for Non-Profits which is now in its 14th
year; our hikes to the hill where we have brought busloads of folks to talk to
our government representatives; and our annual fundraisers for programs like
the South Jersey Food Bank, Toys for Tots, Urban Promise, Hurricane Sandy NJ
Relief Fund, Catholic Charities, etc…
We have also impacted the community by providing programs
for a broad expanse of the workforce spanning from college students to young
professionals to programs for lone rangers and Sr. Executives. We have a Career
Management Program available to those employed and in transition. Our workforce
readiness committee has collaborated with returning vets, other individuals in
the job market and, just last year
we launched a year-long initiative raising member awareness on issues of
diversity and inclusion.
In a recent survey of our over 400 members, it was
confirmed that our members most value the information and learning they receive
from Tri-State and the networking opportunities at our monthly meetings, ½ day
seminars, full day conferences and networking events.
Notwithstanding all this positive business impact, Tri-State
is a group of truly good hearted, warm and friendly people who demonstrate not
only the best in a professional association but also the best in being really
great people.
For more information, please call us at (856) 428-7585. We look forward to seeing you.
The HR Person of the Year Award Dinner will be held on Thursday, May 21, 2015 at Vie in Philadelphia. Click here for more details. Honoring Human Resource
Professionals in the Delaware Valley for 15 Years!
The Delaware Valley HR
Person of the Year Award was developed in 2001 to celebrate the Human Resources
industry and to recognize those in the HR profession who exemplify outstanding
achievement within our local human resources community. Help us celebrate our
15th year by attending the event that honors HR professionals and gives back to
the Delaware Valley community. Regionally, we have approximately 5,000 HR
professionals. Could you or someone you know be the next HR Person of the Year?
Visit the website to nominate an individual who exemplifies outstanding
achievements within the local HR community for one of the following awards: HR
Person of the Year, HR Consultant of the Year, HR Rising Start of the Year. To
learn more, visit our website www.HRPersonAward.org
The following Tri-State Members have been recognized as the HR Person of the Year Award from 2004-2014: Donna Jack, SPHR, Dorothy Stubblebine, SPHR - Lifetime Achievement Award, Anneliese McMenamin, SPHR, Judy Baker, John Baldino, SPHR, Jeff Backal, Aaron Boucher, PHR, Laraine Knauss, SPHR, Margie McLaughlin, SPHR, Monica McClintock, SPHR, Theresa McGlinchey, SPHR, Carol Asselta, SPHR, John Knoop, SPHR and Diane Wagner, SPHR.
Meet April Speaker
Steve Van Valin
Register Here
our tradition of giving back to the community, we will be hosting a Chance
Auction at the 2015 Tri-State Human Resource Management Association (HRMA)
Annual Conference to benefit the Food Bank of South Jersey.
We are seeking donations and invite
your participation. Past donations have varied in value and creativity and have
included merchandise, gift cards/certificates, tickets for movies, museums,
sporting or special events, etc. To make a donation please email Ron Scully
or call 609-760-6637 .


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The Balt Brawny mobile computer desk comes with wheels and a laminated gray tabletop, which is ideal for those with a laptop or desktop work to complete. However, if you have a desktop computer, you can choose to add a CPU holder accessory that can hold your computer tower; that piece is sold separately.
Heavy-Duty Design
The Balt Brawny mobile computer desk has 1-inch-thick high-pressure laminate tops with an underside stretcher bar for extra stability, so whether you're sorting through old books or using a netbook, the table will support what's on top easily. This table comes with a grommet for cable management too, so you can keep the desktop clear.
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text:
LOOKING for: cornmeal tortilla
Years ago I had a recipe for a type of pancake/tortillla made with cornmeal --- used to layer a stack of them with chili, onions, tomatoes, cheese and salsa - for a great throw together Mex meal.
Haven't made this dish in years and can't find recipe now. Any ideas on what this recipe is? Thanks.
Sounds like what we call corn cakes? It's really nothing more than a cornbread batter that is ladled onto a hot griddle or frying pan just like you would pancakes. In the south we use self-rising cornmeal mix, add an egg, a TB of sugar (or not) some bacon drippings or oil, and buttermilk; mix it all in a bowl and ladle about 1/4 cup per cake; cook until brown on the first side and flip to cook the other side.
The are good with fresh corn kernels added to the batter too.
Just google corn cakes or corn pancakes or use your favorite cornbread recipe. If the batter seems too thick just add a little more milk or buttermilk.
Maybe something like this?
Can be layered with chicken, beans, etc....
I prefer homemade corn tortillas but store bought will work too.
Home Cookin Chapter: Recipes From Thibeault's Table
Stacked Enchiladas
Source: Southwest Cookbook
Vegetable oil for frying
12 corn tortillas (6 inches)
1-1/2 cups (12 fl ounces) chili Chili Sauce (recipe on page 195)
2 cups (8 ounces) grated Monterrey Jack or Cheddar Cheese
3/4 cup finely chopped onion
Preheat oven to 350°F. Pour vegetable oil into a medium , heavy skilled to depth of 1/2 inch. Heat the oil over medium high heat to 375°F, or until a strip of tortilla browns in 60 seconds. Soften the tortillas, one at a time, for about 5 seconds per side in the hot oil and drain on paper towels.
Heat the green chili sauce in a shallow pan and dip each softened tortilla into the sauce. Place 1 coated tortilla on an oven proof plate and top with 1 tablespoons green chili sauce, 2 tablespoons grated cheese and 1 tablespoon chopped onion; repeat twice so that 1 serving contains 3 layered tortillas. Repeat with the remaining ingredients to make 4 tortilla stacks. Bake the stacks for 3 to 5 minutes, or until the cheese melts.
NOTE: Add cooked chicken and or pinto or black beans between layers.
Green Chili Sauce
1 Jalapeno chili seeded and diced
1 garlic clove crushed
1/4 cup chopped green onions
4 tomatillos, husked and diced (or use canned)
1-1/2 cups chicken stock
2 new Mexico green or Anaheim chilies, roasted, peeled, cored, seeded and diced.
1/4 cup chopped fresh cilantro
1 tablespoon fresh lime juice
1 tablespoon heavy cream
Salt and freshly ground pepper to taste
In a medium saucepan, place the jalapeno , garlic, green onions, tomatillos and chicken stock. Bring to a boil over medium-high heat' reduce heat and simmer until the liquid is reduced to about 1 cup about 15 to 20 minutes.
Pour the chicken stock mixture into a blender or food processor. Add the Anaheim chilies, cilantro and lime juice; puree until smooth. Add salt and pepper. Add the cream and mix again. Serve warm. Keep 1 to 2 days refrigerated.
Here is a link that might be useful: Corn Tortillas


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With great exitement Snuza was allocated their booth amongst hundreds of other exhibitors at the Hong Kong Baby Fair which started on the 11th of January 2015. Visitors are unaware of all the preparations behind the scenes to make the show worthwhile for their visit. Stand displays and goods get packaged way before the show to be sent from countries all over the globe. All this is to showcase their premium products over a few days for the world to see. Exhibitors chat amongst themselves, lend a hand or a hammer to get the stands looking attractive the day before the show. With great excitement the doors open. Visitors stop and chat to Exhibitors who eagerly await their presence. Snuza left South Africa with great expectations. They were met by a welcoming crowd of traders and Distributors. Snuza's products were introduced to the Asian market who was not very familiar with these portable Baby Movement Monitors, but showed a lot of interest. Snuza enforced their relationship with their Distributor in Asia in order to grow Snuza's presence in the Asian market. We are excited to see more moms having access to a Snuza Movement Monitor. The show doors closed on the 15th of January after a succesful and satisfying show.
Snuza exhibited at the CBME Expo, Istanbul between 15-18 Jan 2015. The stand displayed the Snuza brand for the first time at this show.
There were more than 350 exhibitors. Most of the products on display were mostly known to the visitors. Snuza proudly displayed their products at the show and was recognised as the only company at the Expo, who show cased brand new, unique and high technology products. The Snuza Hero attracted a lot of interest as an innovative product on display.
This was the first time that Turkish parents were introduced to this portable, cordless movement monitor. They were very impressed by the perfect sensitivity of the device. Not only did we get good brand exposure but it created a lot of interest in movement monitors.
It looks like Snuza will soon become a very reliable brand in the Turkish Market.
Snuza is proud to announce that they are now a member of JPMA.
JPMA's very prestigious certification program has spread its message of safety for more than 30 years guiding retailers and parents. Voluntary Standards for JPMA Certified Products are developed by ASTM International, a highly regarded non-profit organization and the largest standard setting organization in the world (www.astm.org).
Snuza attended the K&J Show in September 2014. Thousands of retailers and buyers make their way to the K&J Show every year. An exhibition hall that takes days to cover is filled with exitement as everybody showcases their products with pride. The Snuza products attracted great attention. Not only were the award winning Snuza Hero and Go! on display, but also a prototype of a new product that Snuza will be launching early in the new year.
Snuza has been awarded with the US PTPA award:
Snuza was awarded the PTPA award for Snuza Hero (April 2014), Go! and Trio Plus (September 2014). The PTPA Awards program is all about recognizing and celebrating great products or services that families love. The PTPA Seal of Approval is awarded by having members of 60,000 families test and evaluate products in their homes. If they feel the product or service makes the cut, it earns the Seal of Approval and PTPA helps spread the word about it.
Snuza participated in a great exhibition at Harrogate UK Nursery Fair from 23rd to 25th of March 2014. Various wonderful products were on display. Snuza however stood out with its unique baby movement monitors, the Snuza Hero and Go!. A lot of interest was shown by the trade. The show provided Snuza with an opportunity to make the brand more known and to give retailers an opportunity to make the Snuza products available in their stores, making the Snuza products more accessible.
As of September 2012, we have changed the Snuza HALO model name to Snuza HERO. Everything stays exactly the same - the only change is the name and the packsize.
The main reason we've changed the name is to avoid brand confusion with another product. Our leading-edge products are unique and we feel they deserve their own unambiguous space in the market.
After some research in the marketplace, we decided to optimise our shelf-presence by increasing the Hero packsize. The footprint however remains the same, meaning that we don't actually take up any additional shelfspace other than in height.
If you have any questions or queries, please email firstname.lastname@example.com or contact your national Snuza distributor (see the Contact Us page).
In February the Mexican Pediatrics Association organized their "5th Annual Meeting of the Americas".
About 1800 delegates, half of whom were Pediatricians, attended the AMA which was held in the World Trade Centre in Mexico City.
Our Snuza distributor in Mexico, Luis Alonso Ruiz Shelley of LA-RHO Global Trade, took part as an exhibitor. He managed to distribute surveys and gather data from 129 Pediatrician delegates, with a resoundingly positive feedback about Snuza Mobile Baby Monitors. They were keen to receive further information about Snuza products and were agreeable to recommend it to their patients. Well done, Luis!
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Need tips on removing dust from drywall
We are getting set to start painting our new house. The drywallers just finished up yesterday morning. My husband and I went over last night to start some prep work. Does anyone have any good recommendations on removing drywall dust from the walls? We wiped everything down with a tack clock but sometimes it seemed like we were just moving the dust around the room. Any suggestions in making this prep work go smoothly would be appreciated. Thanks.
Please don't use a wet sponge or anything with water on your new drywall. The topping compound they use over the seams and nail heads is a very lightweight material that is feather sanded to perfection and wiping over that with a damp sponge can very easily screw that up. Do not agonize over removing every last spec of drywall dust from your walls before painting. The important thing is to not paint over big piles of it because that could affect adhesion. You can very easily have your walls in ready to paint condition with a leaf blower or a vacuum or a big push broom. Michael can use water and a damp sponge and rinse 15 times if he wants in his own home..that doesn't mean you need too. It's pretty clear he's a bit of a nut-job anyway. Say no to the water!
Hello dust-fans...,
I've had decent luck with the Shop-vac route myself. You'll need a few repl. bags, since the dust is so fine!!
>>> You DO realize that you have to prime b-4 any painting don't you??!! You'll regret it if you don't!!
>>> Will your walls be smooth; or are you having the "orange-peel" texture sprayed on?
* If smooth walls...you may want to sand the prime-coat when it's well dried. Yes...MORE vacuuming here! Reason: the water in most primers will "fuzz" the paper in the drywall a bit. You'll get more of a glass-like look if it's sanded after priming! Use a 220 or higher sanding screen.
* If textured walls...prime after the material dries-the next day usually.
>>> If using dark colors: Use a med.-gray primer (unless you like applying 4 to 5 coats of some reds...).
Thanks for the tips. I didn't mean to start a war between paintguy and brushworks but it sound like you guys have ruffled each others feathers before.
To faron79: Yes our walls are smooth and I am going to prime everything. We are renting a sprayer on Thurdsday and hope to have everything prepped for then. Last night we used a soft bristle broom on the walls in addition to the tack cloth and that seemed to work better. I am going over today to use the shopvac and check the walls in the light of day.
Maybe it is the homemaker in me but I keep feeling like I need to get all the dust off. I guess that is not realistic or even necessary. Thanks again for the tips and if anyone has any other suggestions on prep work I am all ears.
There is no war between Michael and me. He's just goes really, really far with his prep and that's fine if he wants to do it in his own home and it's fine if he wants to suggest that you do it in yours. I'm just saying that doesn't mean you have to. The first thing I visualized was some homeowner climbing a ladder with buckets of water to wipe down drywall dust in a 2 story foyer and that is just bigtime overkill and just simply not necessary IMO. Get the majority of the dust off the walls and get to painting!
I need to chime in to paintguy, Michael/brushworks did not post anything about climbing up ladders with buckets of water. If you read his post again you will note that he suggested a damp sponge, and using the two bucket rinse system for water. What you may consider overkill, others may not. I have found the information, suggestions and encouragement on this site invaluable. While one might not agree with everything, I don't think calling people names like "nut-job" is acceptable.
We're at the milestone as the original poster with drywall just completed in our new home and getting ready to use paint sprayer to prime.
I've heard the swiffer suggestion before and wonder whether the DRY swiffer cloth or WET swiffer cloth?
The DRY swiffer seems like it would just push the dust around (although probably be enough on the ceiling to knock dust to the floor).
Wonder if the WET swiffer is too wet? I've never used a swiffer so not sure how wet the wet swiffer is.
And how often should you change the sheet? Wondering how many cloths to buy.
I don't know what kind of chemicals are in a wet Swiffer, but I sure wouldn't want find out how they react to paint on my walls! Another vote for your basic damp sponge.
I recently moved into a place that has some of the worst paint jobs I've seen. The two room I've painted so far had failing paint. Based on what I found during prep, I'd say that the original painter didn't clean off the drywall dust.


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Eric Larson, 45, from Lafayette, Colo., had been skiing at Arapahoe Basin Ski Area when he collapsed at the bottom of a hill on Dec. 26, according to the Summit County Coroner's Office. He was taken from the ski area to St. Anthony's Hospital in Lakewood via a Flight For Life helicopter and died within minutes of being admitted to the emergency department, the coroner reported. An autopsy has been scheduled.
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Artist Search
Ernest Parton
(1845 - 1933)
About: Ernest Parton
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New York / England
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landscape, genre, animal and interior painting
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When Lingering Daylight Welcomes Night
Artwork images are copyright of the artist or assignee
This biography from the Archives of AskART:
The following biogoraphy is from John Finnegan.
Ernest Parton was the younger brother of Arthur, in whose studio he spent two winters. However, he received no instruction in art from regular masters or in any schools. He was elected a member of the Artists' Fund Society of New York in 1873, contributing one work each year to its sales. In 1873, he traveled to Europe for the purposes of spending a few months mainly in Great Britain, but, meeting with success in London, he decided to remain, exhibiting at the Royal Academy and elsewhere.
In 1876 he visited the Swiss Lakes and Northern Italy, making many sketches. He returned to New York in 1884 through 1886. Among his most notable paintings are:
Morning Mist
, exhibited at the National Academy (NAD) in New York, and the following exhibited at the Royal Academy in London:
Papa's Lunch, The Placid Stream, Sunny September, Poet's Corner, The Silent Pool, Reflections,
The Duck Pond.
Artists' Fund Society, Royal Institute of Painters, London
Alpine Society, Dowsdell Galleries Earl's Court, 1897 Edinburgh, 1886
Fine Art Society, London Glasgow Institute of Art Grosvenor Galleries 1875-1880
Manchester City Art Gallery, Manchester Jubilee, 1887
National Academy of Design 1866-97
New English Art Gallery, 1893
New Gallery, London Paris Exhibitions 1889 & 1900
Paris Salon 1892 & 1894
Pennsylvania Academy of Fine Arts 1905
Royal Society of British Artists Royal Academy, Birmingham Royal Academy 1875- 1932
Royal Hibernian Society, Royal Institute of Oil Painters, Toothe, Arthur & Sons,
, 1893, Walker Art Galley, Liverpool
South Kensington Museum, Tate Gallery, Walker Art Gallery, Reading Museum, Salford Museum, Sunderland Museum
Sources include:
Benezit, E. "Dictionnaire des Peintres, Sculpteurs, Dessinateurs, et Graveurs, Gr�nd", 1999.
Clement & Hutton, "Artists of the 19th Century and their Works", Boston 1879.
Champlin & Perkins, "Cyclopedia of Painters and Paintings", Vol. III, NY 1887.
Falk, Peter H, "Who Was Who in American Art", Soundview Press, 1999.
Fink, M. "American Artists at the 19th Century Salons"
Fielding, Mantle, "Dictionary of American Painters, Sculptors, and Engravers", New York, 1926
Graves, A., "A Dictionary of Artists 1793-1893, who have exhibited works in the Principal London Exhibitions", Kingsmead Press 1904
Graves, A., "A Century of Loan Exhibitions", Bath 1915.
Graves, A. Royal Academy of Arts, "A Complete Dictionary of Contributors and their work from the foundation in 1769 to 1904", Vol. III. H. Graves, 1905
Jarmon, A. "Royal Academy Exhibitors", 1905-1970, Vol. III, 1987
Johnson, Jane, "British Artists 1880-1940," ACC, 1980
Johnson, Jane, "The Royal Society of British Artists, 1824-1893", ACC, 1975
Poynter, The National Gallery, 1900.
Schmidt, Mary, "Index to 19th Century American Art Periodicals", Soundview Press, 1999.
Thieme-Becker, "Allgemeines Lexikon Der Bildenden K�nstler Von Der Antike Bis Zur Gegenwart, Seemann", band 25/26, Leipzig 1999
Waters, B. "British Artists Working 1900-1950",
Wood, C. "Dictionary of Victorian Painters", ACC 1975
Biography from
Jeffrey Morseburg
For more than fifty years, the expatriate American artist Ernest Parton enjoyed great success in England with his paintings of the English and French countryside. A true cosmopolitan, Parton did works combining elements of the Hudson River School tradition that he was trained in as a young man with influences drawn from the French Barbizon School and the late-Victorian landscape movement to create a sophisticated international style that made him a sought after and affluent London painter.
Parton won his fame by showing his works in the major salons and exhibitions of the day including the Royal Academy, The Royal Scottish Academy, the National Academy of Design in New York, the Paris Salon, the Exposition Universelle in Paris and the Chicago World's Fair. The large-scale paintings that he completed for these major shows and expositions - works such as
The Waning of the Year
When Lingering Light Greets Night's Pale Queen
- were reproduced in art magazines and as fine prints, securing his reputation on both sides of the Atlantic.
Ernest Parton was born into a large and talented family who lived in the riverside community of Hudson, New York, located in the Hudson River Valley, just north of New York City. His father George Parton (1812-1872), who came from Birmingham, England, immigrated to the United States in 1833 and married Elizabeth Woodbridge of Mystic, Conniecut the following year. The Parton family grew rapidly, the growth rate only interrupted by George Parton's two lengthy trips west, in 1849 and 1852, where he searched in vain for fortune in the gold fields of California. Of twelve children, only six survived to adulthood, three girls and three boys, all of whom became fine artists.
For an artistically talented American youth growing up in the middle of the 19th century, there were few better places to live than New York's Hudson River Valley. Thomas Cole (1801-1848), the founder of the Hudson River School, began sketching in the valley in the 1820's. Sanford Robinson Gifford (1823-1880) grew up in Hudson, New York, just across the river from Cole's home, and Frederic Church (1826-1900), Cole's prot�g�, built a Moorish castle overlooking a bend in river. These were three of the major figures in what was the first great American artistic movement. The loose association of artists who lived or painted in the Hudson River Valley was drawn together by the influence of the Transcendental movement and the peace and beauty of the valley and the surrounding Catskill Mountains, and their school would come to dominate American art for more than half a century.
It is impossible to assess the life and work of Ernest Parton without discussing his older brother and mentor, Arthur Parton, who was born in 1842. Arthur was the fourth child of the Parton family and the oldest of what eventually became an artistic trio. He was an artistically talented youth, so despite parental reservations, he was sent to Philadelphia to study at the Pennsylvania Academy of Fine Arts under the great landscape and marine painter William Trost Richards (1800-1900). He was a talented and resourceful student and began exhibiting at the National Academy of Design in 1861, while still in the final year of his art education. After his studies, Arthur Parton began working extensively out of doors with William Trost Richards and other members of the Hudson River School, who lived in the valley.
Though his father wanted to make a merchant out of him, Arthur's younger brother Ernest Parton also began to exhibit artistic talent and an interest in becoming a painter. In 1864, his brother Arthur wrote to him with advice: "If you think of following painting as a profession, the best thing you can do for a year at least, though you have only a few minutes a day to devote to it, is to practice directly from nature. Try to draw as nicely and truthfully as you can before sitting yourself down to taking lessons, as Richards advises, or rather told me when I first went to him. I know that what little advances I have made within a few years is owing not to instructions from any master, but to labor out of doors?"
In his teenage years Ernest began to accompany Arthur on sketching trips along the Hudson and in the Catskill Mountains and to work alongside his brother in the studio. Because he had Arthur to study with and other artists to rely on for advice and to join on sketching outings, he did not feel the need to enroll in an academy for formal training. After all, this was the er
In 1865, the year that the Civil War ended, twenty-year-old Ernest joined his brother in his studio on Broadway, in New York City and was soon exhibiting his own works at the National Academy of Design. In 1869 Arthur Parton embarked on an extended trip to England and the continent where he came under the influence of the French Barbizon School and came to know the other new artistic movements. When he returned, the older brother's work began to change, and through his influence, Ernest's maturing work began to grow as well.
In 1873, after he had sufficient confidence in his art, Ernest Parton followed in his older brother's footsteps and left for an extended trip to Europe. Because Arthur's paintings of the Scottish lochs and English countryside were selling well in America, the trip was probably motivated as much by the realities of the commercial marketplace as it was by artistic reasons. Parton landed in Glasgow, painted in the Scottish Highlands, then in the scenic Lake District of England and finally in the Welsh countryside. He soon found that he enjoyed England and that in return, English buyers responded to his work. Ernest's success motivated Arthur to give him some sage advice once again, "We read that you appear to be getting along in a swimming manner?Certainly I should try to make the most of your opportunities while there, chiefly on account of the flatness of everything in New York and all across the country."
Parton installed himself in a studio on Newman Street in London, and set about adapting to a new land and a somewhat different culture. With the U.S. mired in a long period of economic doldrums, Parton found commercial success in England and soon became a respected painter in the late-Victorian artistic milieu. As an American expatriate artist, he was in good company, for in the last decades of the century John Singer Sargent, George Boughton, Frank Millet, James McNeil Whistler, and Edwin Austin Abbey had all settled in England. Eventually he lived in fashonable St. John's Wood and had a studio in picturesque Wargrave-on-Thames.
In 1875, two of Ernest Parton's works were accepted by the Royal Academy, and he began a long run of success in the Academy's annual exhibitions. In 1876, he painted extensively on the Continent, doing sketches at Lake Como and painting in the Italian countryside. In 1877 his interest in the French Barbizon School sharpened, and he became part of a circle of Anglo-American painters who spent their summers in the French countryside. In 1879, the Royal Academy's Chantrey Bequest purchased Parton's picture
The Waning of the Year
for the permanent collection.
In addition to his English subjects, Parton traveled and painted extensively in France, and contemporary critics saw a marked difference between his French and English pictures. While most of his paintings were painted at the end of the day, which used to be called "eventide," the French paintings tended to be more atmospheric, revealing the influence of the Barbizon School. This influence was inevitable as he was part of a circle of painters that painted and socialized in the small village of Grez-sur-loing, a short distance from Barbizon.
Even though he spent most of his life as an expatriate, Parton's American heritage was important to him, and he continued to send paintings home for exhibition. In 1893, he sent
When Daylight Dies
Close of the Day
home for the World's Columbia Exposition, the Chicago World's Fair, where they were exhibited in the American Pavilion. Parton also exhibited with the National Academy of Design in New York. Some of the paintings were American scenes that he painted on trips home; others were Barbizon-tinged scenes of rural France, and the remainder were his depictions of the English countryside.
At the end of his life, Parton returned home one final time to die at the age of eighty-eight. Over the course of his long life, the world of art had changed dramatically, with artistic tastes and styles shifting rapidly as one new movement succeeded another. However, throughout his lifetime, Ernest Parton remained true to his own vision of the landscape - a contemplative, restful and poetic transcription of the natural world.
Jeffrey Morseburg
copyright 2006
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"Your customer service is exceptional! Please pass this to whoever gives out the raises! Thanks again for the prompt response!"
When doing a peyote stitch, what is the best stringing material - thread or Accu-Flex® beading wire?
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It wasn't easy judging the 2014 Fire Mountain Gems and Beads® Swarovski Contest, but Sonia Lidozzi's stunning piece, with its fabulous combination of energetic color, textural intrigue and talented techniques, captivated judges and earned the Grand Prize Gold Medal. See the award-winning pieces in all their glittering glory with direct links to view the spectacular finalists up close and personal in the Gallery of Designs.


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Charles Starkweather, the real-life basis for such serial-killer films as Terrence Malick's "Badlands" and Tony Scott's "True Romance", is finally having his story told with a minimum of Hollywood interference (i.e., no stars, no flashy effects) and with an emphasis on the actual events and facts of the gruesome story. While this direct approach may make for a more historically accurate telling of Starkweather's tale, it unfortunately doesn't translate to a very engaging or entertaining piece of film.
Charlie Starkweather (Brent Taylor) and his girlfriend Caril-Ann Fugate (Shannon Lucio) kicked off their killing spree (or, rather, his killing spree, as she kind of just rode along and whined a lot) in Nebraska in 1956, killing 11 people in 3 months. In this version of the story, Charlie was visited at an early age by a sort of phantom "mentor" who goaded him into killing by insisting that it was in his nature to do so. After eluding the police for a number of weeks following the slaughter of Caril-Ann's family and a handful of others, Charlie and Caril-Ann were finally taken into custody on a rural highway as they tried to escape to California, and Charlie was executed shortly thereafter. Caril was imprisoned for 20 or so years, and is apparently still alive somewhere, using an assumed name.
Pretty cut-and-dry. And unfortunately, this telling of the tale doesn't add much to it: the events are laid out end-to-end, with very little conflict or resistance to make things interesting or any narrative to drive the story. We don't particularly care for Charlie and Caril-Ann, and we don't really know where they're going (nor do they). So seeing them wander around killing everyone they come across, while occasionally unpleasant, is really neither disturbing nor interesting. Flourishes like Charlie's hinted-at desires to be the next James Dean and the accompanying imagery (a dream-sequence newsreel is a nice break from the earnestly-composed, cleanly-lit shots that make up most of the film) are certainly the most interesting parts of the film, and one wonders what the movie might have been had the filmmakers gotten more caught up in the inherent kinetic chaos of the story. After all, the most that a filmmaker can hope to contribute to real-life events is to contextualize those events and make them relevant to a new audience; here we see little contextualization or relevance, but rather a parade of classic picture-cars and stilted dialogue scenes.
The biggest single issue I had with Starkweather was the device of Charlie's imaginary "mentor", which allows for a lot of would-be voiceovers to be played out on-screen between two characters (although it's no more interesting that way) and a few "Three's Company"-style misunderstandings when Caril-Ann overhears Charlie talking to his imaginary friend. Again, this could easily have been used as a source of conflict that would help to drive the story, but here it's brought up and disposed of as needed and is ultimately of little relevance. The mentor is voiced by Lance Henrickson, whom the filmmakers apparently couldn't get on-set — his "body double" is a Tim McGraw-looking "dark cowboy" type whose face is conveniently obscured every time he's on-screen, a none-too-subtle and ultimately distracting device.
There were a few highlights to the film, including the performance of Lucio as Caril-Ann, the shifty, Lolita-like muse to Charlie's murderous rampage. Looking not unlike Dominique Swain (oddly), Lucio's performance is a dead-on mix of stupid innocence and calculated wile that plays beautifully. You're never quite sure which direction this girl is going to go, which is more than can be said of her beau, whose tortured pretty-boy routine is fairly flat (again, Taylor is forced to play out most of his inner turmoil against a faceless cowboy, so you can't really blame the actor entirely). Some of the photography is nice in a wistful, wide-open-spaces sort of way, and some of the color work done on the skies was somewhat striking (again, a hint of what might have happened had the content not been treated with such odd reverence).
In all, I found Starkweather to be a technically competent and earnestly-made missed opportunity, lacking the very sort of passion or recklessness that made Charlie and Caril-Ann the infamous figures they are today. These were people who acted in the moment, and to make a contemplative, somber film about them just doesn't make for a very compelling watch. To take away the "thrill" of the original thrill-killers is as much a disservice to them as it is to the audience, and leaves us with a sadly unengaging, amber-tinted history lesson.


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Exploring Int… Oh, Wait, Safari's Hung Again
I will allow you, dear reader, to imagine what was going to be posted in today's Backstage entry, "Exploring International iTunes Stores."
You'll have to imagine it, because this entry—focused on some of the interesting differences between Apple's many iTunes Stores—was entirely lost due to what I'll call "yet another Safari hang-crash." During one of these crashes, Safari randomly locks up, putting a spinning beach ball on the screen and just sitting there until the program is forced to quit. An inspection of Activity Monitor doesn't yield clues as to what's wrong. Trying Flash Player upgrades to the latest version doesn't seem to have helped. And having virtually nothing else running doesn't seem to make things better, either.
As I have said before, I love my Macs. Love them. I buy extra ones for fun. But these crashes in Leopard, like the graphics glitches and external monitor issues shown above, are just killing me. I never thought I'd see the day when I would consider going back to a Windows PC, yet every one of these hangs, crashes, and bugs makes me think about it, if only for a moment. Is the solution a retrograde to Tiger? Or something else?
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Oh you too got the "artistic" crash ? :-)
Posted by Florian on March 26, 2008 at 6:41 PM (CDT)
Tried another browser?...
Posted by Bob Levens in UK on March 26, 2008 at 7:02 PM (CDT)
I get that all the time too. It seems to happen when there's a few tabs or more open and it's completely annoying because when you have like 8 tabs open there's a reason you have them open, and when it crashes you lose all of what you're doing. I thought it was the various input managers I had installed which included Safari Adblock and Inquisition but after deleting them it still crashes.
Looking at the crash log you can see that a bunch of threads are deadlocking(look for sem_wait on every thread). This means that every thread is waiting for every other thread to complete but none are completing so the app hangs. I can't figure out what the problem is but for now I've actually switched to Firefox for some stuff because this is getting ridiculous.
Posted by Devon on March 26, 2008 at 7:14 PM (CDT)
I like when 1% of the people have a problem but they act like it effects everyone. I have never seen or even heard of the above mentioned problems. I work 8 + hours a day as a web designer and never seen these problems. So your going to switch back to windows cause a small bug happen to happen to you?
I bought a CD that had a broken case last week. Maybe I should never buy a CD again and tell everyone else not to either.
More than likely the problems come from installing hacks upon hacks like Devon mentioned in his post.
Posted by nosedive51 on March 26, 2008 at 8:01 PM (CDT)
Don't let whatever that is stop you!
I'd really like to hear your perspective on browsing international iTunes Stores!
Personally, I find checking what's at the top of the iTunes charts in the UK store a really great way to discover great music.
I always leave wondering why their music costs more, and why they have more EPs/singles/exclusives, and why certain things that are available here aren't available there and vice versa.
Also, does anyone know how I can purchase UK iTunes gift cards?
Posted by jeremyjk1221 on March 26, 2008 at 8:51 PM (CDT)
Florian: Many of them, and in different variations. Some within a Finder window. Some taking up the entire screen. Started with 10.5.2 and the related Leopard Graphics Update.
Bob: I will now.
Devon: It does seem to happen with multiple tabs open, but I'm honestly not sure what the cause is. I go through the crash logs hunting for explanations but can't make much of them. Probably 25% of the Safari crashes I have these days posit (via dialog boxes) that Flash Player has a problem with Safari (or, perhaps more accurately, that Safari now has some issue with Flash Player), but the other crashes don't blame anything specific. They're mostly hangs. No input managers installed, at all.
Nosedive51: I have zero hacks installed. No crazy applications running in the background. Maybe because it's I work 14 hours a day on my Mac—perhaps the crashes only happen during those extra 6 hours. (...sigh…) Or maybe it's because I'm not the only one with these sorts of issues. Try reading the many discussion threads out there where other people are experiencing the same things and struggling for solutions. In any case, congrats on having a completely stable system; my guess is that you're using either a desktop Mac or a PPC one.
JeremyJK: I will see about retyping it tomorrow. My screengrab of the crash only caught the last few sentences.
Posted by Jeremy Horwitz in East Amherst, NY, USA on March 26, 2008 at 9:24 PM (CDT)
I'm glad, in a way, it's not just me. Safari 3 is just as crashy on my new Penryn MacBook as it was on my PowerBook G4. I use Safari only because I need to sync bookmarks with my iPhone, but if I'm after faster, crash-free browsing I always use Firefox 3 - even in beta, it's streets ahead of Safari 3.
Posted by John Brissenden on March 27, 2008 at 4:18 AM (CDT)
I regularly have 50 or more tabs open in Safari, but have never seen anything like that.
Posted by Galley in Greenville, SC on March 27, 2008 at 9:28 AM (CDT)
Galley: I hope those tabs are spread across a few windows. :-)
The pictures are, as mentioned in the piece, from separate video issues. When Safari has problems, it just beachballs or crashes with a dialog box.
Posted by Jeremy Horwitz in East Amherst, NY, USA on March 27, 2008 at 9:53 AM (CDT)
Camino, baby! Ever controversial Safari 3.1 may be very stable and pretty on Windows, but it's an old dog with missing teeth on a Mac oddly enough. Camino is just as simplified and streamlined (more so, imo) but without all the memory leakage and holes. I just wish they'd get it compiled for Linux…
Posted by Christopher on March 27, 2008 at 3:02 PM (CDT)
I have never had said problem and suggest it's probably some software you've installed, something of an enhancer, plug-in or system or browser utility and not Safari or Leopard.
Posted by Erik on March 28, 2008 at 12:38 AM (CDT)
Have the same issues on a 3.0 Mac Pro with 10.5(.2) installed. Switched to Webkit as my browser (http://webkit.org). It's a really nice replacement for Safari, as it just works with the same bookmarks etc. It's also much faster than Safari, and I routinely have it open with 60-70 tabs, no problems in 99% of the cases. Some sites still do make it crash, but that is a rarity as opposed to very common with Safari. On my iMac G4 (yes, I also have a varied collection of useable Macs around my desk), running 10.4.11, Safari 3.1 just crashes on start-up. Disappointing. As for the screen artifacts, I don't know what machine/graphics card you are running, but mine is the ATI X1900XT, and I would get those artifacts on occasion too (although not as bad as shown above) on my Mac Pro. Seems Leopard makes the graphics card work much harder than Tiger (where the same machine never had any issues). Problem apparently is in some versions of the card, that run hot, and create the artifacts. In addition, on my machine, when that occurs, there is a tendency for the USB connections, which are located just below the graphics card, to cause a kernel panic. I have spoken to Apple Support the day before yesterday, and after going through the routine of checking the firmware on the card (there is an X1900XT firmware upgrade on the Apple website(http://www.apple.com/downloads/macosx/apple/firmware_hardware/atiradeonx1900xtfirmwareupdate.html)), and checking that the card was dust-free, they decided to ship me a replacement card. I cannot say yet whether that will help, as I haven't received it yet. The USB issues are probably related to the graphics card issues, but again, that awaits arrival of the replacement card.
Posted by Steven Pelsmaekers on March 28, 2008 at 1:21 AM (CDT)
Steven: I have seen small USB issues and bigger ExpressCard issues since Leopard as well. My video card is a GeForce 8600M GT. I might be wrong but am willing to bet that the replacement card doesn't make a difference. The most likely issue is that there is a bug in the video drivers, one of Leopard's rendering technologies, or the system's bus management software, possibly all three.
Posted by Jeremy Horwitz in East Amherst, NY, USA on March 28, 2008 at 7:50 AM (CDT)
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IN MEMORIAMS: IN LOVING MEMORY JACK TOBACK March 15,1910 - May 17, 2003 HAPPY BIRTHDAY! We Miss You You were truly the Best! All Our Love Libby, Amy, Alec, Amanda, Kim, Oliver, Macie Rose, Andy, Amber, JadeMore info Email a friend
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text: Beach Fails [VIDEO] By Joe July 15, 2014 9:23 AM Share on Facebook Share on Twitter Let's hope the Beach Bash at Mickey Rats this Saturday goes a little better than this. There is still time to get tickets, even if you have to get them at the door…just no free drink for you! Get Details On The Beach Bash! Filed Under: Ban Bon Jovi Beach Bash, nl Category: Jack Around Town, Jacktube Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of 92.9 Jack FM Recommended For You Around the Web


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The present invention relates to the use of certain indolone derivatives in particular, 4-(2-di-n-propyl-aminoethyl)-2-(3H)-indolone in a method of treatment of Parkinsons disease.
1. A method of treatment of depression which comprises administering an effective non-toxic amount of a compound of structure (I) ##STR2## in which each R group is hydrogen or C1-4 alkyl;
R1 and R2 are each hydrogen or C1-4 alkyl;
R3 is hydrogen or hydroxy; and
n is 1 to 3;
or a pharmaceutically acceptable salt thereof to a subject in need thereof.
2. A method of treatment of depression which comprises administering an effective non-toxic amount of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone to a subject in need thereof.
3. A method of treatment of depression which comprises administering an effective non-toxic amount of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone hydrochloride to a subject in need thereof.
4. A method of producing anxiolytic activity which comprises administering an effective non-toxic amount of a compound of structure (I) ##STR3## in which each group R is hydrogen or C1-4 alkyl; R1 and R2 are each hydrogen or C1-4 alkyl;
R3 is hydrogen or hydroxy; and
n is 1 to 3;
or a pharmaceutically acceptable salt thereof to a subject in need thereof.
5. A method of producing anxiolytic activity which comprises administering an effective non-toxic amount of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone to a subject in need thereof.
6. A method of producing anxiolytic activity which comprises administering an effective non-toxic amount of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone hydrochloride to a subject in need thereof.
This is a continuation of application Ser. No. 196,653 filed May 19, 1988, now U.S. Pat. No. 4,824,860 granted Apr. 25, 1989.
The present invention relates to a method of treatment of disorders of the central nervous system, in particular Parkinsons Disease, by the administration of certain indolone derivatives.
Parkinsons Disease is a disturbance of voluntary movement in which muscles become stiff and sluggish, movement becomes clumsy and difficult and uncontrollable rhythmic twitching of groups of muscles produces characteristic shaking or tremor. The condition is believed to be caused by a degeneration of pre-synaptic dopaminergic neurones in the brain. The absence of adequate release of the chemical transmitter dopamine during neuronal activity thereby leads to the Parkinsonian symptomatology.
Currently, the most widely used treatment for Parkinsonism is administration of L-DOPA, a precursor of dopamine which acts indirectly by replacing the missing dopamine. However, disadvantages are associated with the use of L-DOPA, for example, patients often suffer from side-effects such as dyskinesia and on-off effects, and it is necessary to administer L-DOPA in conjunction with a peripheral dopa-decarboxylase inhibitor such as carbidopa or benzaseride. These inhibitors prevent the peripheral degradation of levodopa to dopamine, thus enabling more drug to enter the brain and limiting peripheral side-effects. Such treatment improves quality of life for patients but does not halt disease progression. Furthermore, such treatment is associated with a number of adverse effects including nausea, vomiting, abdominal distension and psychiatric side-effects (for example, toxic confusional states, paranoia and hallucinations).
An alternative form of therapy is to administer post-synaptic dopamine agonists, for example ergot alkaloids such as bromocriptine-however, this approach is also associated with side-effects. For example, patients receiving bromocriptine often experience dyskinesia psychiatric problems, and in a small number of cases experience vasopastic phenomena and angina. In addition bromocriptine also causes psychiatric side-effects such as hallucinations.
In view of the foregoing, it is clear that there is a continuing need for the provision of effective safe medicaments for the treatment of Parkinsonism.
It has now been found that certain indolone derivatives known in the art as pre-synaptic D2 -agonists having utility as cardiovascular agents (see EP 113964-B), also are post-synaptic D2 -agonists in the brain and hence are expected to have utility in the treatment of Parkinsonism.
This finding is particularly interesting since such compounds have previously been reported as not being capable of producing the central behavioural effects often seen with dopamine agonists (see Gallagher, G., Jr. et al., J. Med. Chem. 1985, 28 1533-1536). In addition, the compounds of the present invention show distinct unexpected advantages over known dopamine agonists in having been found to have additional effects on the central nervous system, namely, anti-depressant and anxiolytic effects. Furthermore, preclinical studies appear to indicate that the compounds show minimal liability to cause dyskinesia. In particular the anti-depressant and anxiolytic effects of the compounds of the present invention are perceived to be advantageous as patients receiving current therapies often also need to take separate anti-depressant medication. The presence of such qualities in a single compound may therefore reduce the need for such separate therapy.
The present invention therefore provides a method of treatment of Parkinsons Disease which comprises administering an effective non-toxic amount of a compound of structure (I) ##STR1## in which
each group R is hydrogen or C1-4 alkyl;
R1 and R2 are each hydrogen or C1-4 alkyl;
R3 is hydrogen or hydroxy; and
n is 1 to 3;
or a pharmaceutically acceptable salt thereof to a subject in need thereof.
Preferably, both groups R are C1-4 alkyl in particular propyl and R1 and R2 are both hydrogen.
Suitably R3 is hydroxy; preferably R3 is hydrogen.
In particular preferred compounds for use in the method of the present invention include the compound of structure (I) in which both groups R are propyl, R1, R2 and R3 are hydrogen and n is 2 namely, 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone or a pharmaceutically acceptable salt thereof.
Suitable salts will be apparent to those skilled in the art and include, for example acid addition salts, preferably the hydrochloride.
The compounds of structure (I) and their pharmaceutically acceptable salts can be prepared by the methods described in U.S. Pat. No. 4,452,808.
In therapeutic use for the treatment of Parkinsonism, the compounds are incorporated into standard pharmaceutical compositions. They can be administered orally, parenterally, rectally or transdermally.
The compounds of structure (I) and their pharmaceutically acceptable salts which are active when given orally can be formulated as liquids, for example syrups, suspensions or emulsions, tablets, capsules and lozenges.
A liquid formulation will generally consist of a suspension or solution of the compound or pharmaceutically acceptable salt in a suitable liquid carrier(s) for example, ethanol, glycerine, non-aqueous solvent, for example polyethylene glycol, oils, or water with a suspending agent, preservative, flavouring or colouring agent.
A composition in the form of a tablet can be prepared using any suitable pharmaceutical carrier(s) routinely used for preparing solid formulations. Examples of such carriers include magnesium stearate, starch, lactose, sucrose and cellulose.
A composition in the form of a capsule can be prepared using routine encapsulation procedures. For example, pellets containing the active ingredient can be prepared using standard carriers and then filled into a hard gelatin capsule; alternatively, a dispersion or suspension can be prepared using any suitable pharmaceutical carrier(s), for example aqueous gums, celluloses, silicates or oils and the dispersion or suspension then filled into a soft gelatin capsule.
The compounds of structure (I) and their pharmaceutically acceptable salts which are active when administered parenterally (i.e. by injection or infusion) can be formulated as solutions or suspensions.
A composition for parenteral administration will generally consist of a solution or suspension of the active ingredient in a sterile aqueous carrier or parenterally acceptable oil, for example polyethylene glycol, polyvinyl pyrrolidone, lecithin, arachis oil or sesame oil. Alternatively, the solution can be lyophilised and then reconstituted with a suitable solvent just prior to administration.
A typical suppository composition comprises a compound of structure (I) or a pharmaceutically acceptable salt thereof which is active when administered in this way, with a binding and/or lubricating agent such as polymeric glycols, gelatins or cocoa butter or other low melting vegetable or synthetic waxes or fats.
A typical transdermal formulation comprises a conventional aqueous or non-aqueous vehicle, for example, a cream, ointment lotion or paste or in the form of a medicated plaster, patch or membrane.
Preferably the composition is in unit dose form. Each dosage unit for oral administration contains preferably from 1 to 50 mg (and for parenteral administration contains preferably from 0.1 to 15 mg) of a compound of structure (I) or a pharmaceutically acceptable salt thereof calculated as the free base.
The daily dosage regimen for an adult patient may be, for example, an oral dose of between 1 mg and 100 mg, preferably between 1 mg and 50 mg, or an intravenous, subcutaneous, or intramuscular dose of between 0.1 mg and 50 mg, preferably between 0.1 mg and 15 mg, of the compound of structure (I) or a pharmaceutically acceptable salt thereof calculated as the free base, the compound being administered 1 to 4 times per day. Suitably the compounds will be administered for a period of continuous therapy.
Using the compound 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone hydrochloride (Compound A, prepared according to procedures described in European Patent 113964-B) the following tests were performed:
1. Mouse spontaneous locomotor activity using individual cages equipped with photocells.
2. Mouse spontaneous locomotor activity using treadwheels.
3. Mouse spontaneous locomotor activity measuring climbing frame behaviour.
4. Measurement of stereotyped behaviour in the mouse.
5. Rat spontaneous locomotor activity using individual cages equipped with photocells: measurement of stereotypy.
6. Measurement of hyperactivity following direct administration into the mesolimbic nucleus accumbens of the rat. An indicator of anti-depressant activity.
7. Effect on observed locomotor activity following direct administration into the extrapyramidal caudate-putamen (striatum). A test for anti-Parkinsonism potential.
8. Measurement of anti-depressant activity in the mouse using the `Porsolt Test`.
9. Anxiolytic activity in the mouse using a black and white test box.
10. MPTP-treated marmoset model. A test for anti-Parkinson activity.
A. Effect of Compound A on spontaneous locomotor activity in mice.
Compound A caused inhibition of spontaneous locomotor activity in the mouse in each of the first three tests at doses of 1.0 and 10.0 mg/kg i.p. Statistically significant inhibition (P<0.01-0.001) was measured following 10 mg/kg in test No. 1 and 1.0 mg/kg in test No. 3.
Stimulation of locomotor activity, at a statistically significant levels (P<0.001), was seen after 100 mg/kg Compound A in the photocell and treadwheel tests, but not in the climbing test where the original inhibition was reversed. This biphasic activity, also exhibited by amphetamine and apomorphine in these tests, is consistent with that of a dopamine agonist having ability to stimulate presynaptic (autoreceptors) at low doses and post-synaptic receptors at a high dose. (Amphetamine is a known mood enhancer and apomorphine is a standard D2 agonist of the same pharmacological class as compound A). These tests are considered to indicate dopamine agonist activity in both extrapyramidal and limbic systems.
B. Ability of Compound A to induce stereotypy in rats or mice
At doses of 1.0, 10.0 and 100 mg/kg i.p. Compound A caused no dose dependent stereotypies in the mouse or rat (tests 4 and 5). Amphetamine, at doses up to 10.0 mg/kg i.p. and apomorphine, 2.0 mg/kg s.c., produced marked stereotyped behaviour such as continuous biting, gnawing and licking in both species whereas Compound A only caused periodic sniffing.
In these two tests Compound A shows a different profile to other known dopamine agonists suggesting a more selective mode of action.
C. Effect of Compound A on locomotor activity in the rat
Doses of 10.0 l and 100.0 mg/kg i.p. Compound A caused statistically significant (P<0.001), dose-related increases in spontaneous locomotion (test 5) which lasted, at the higher dose, in excess of 2.5 hours. Enchancement of locomotor activity by amphetamine and other dopamine agonists is difficult to measure because it is complicated by the development of stereotypies. When injected directly into the mesolimbic nucleus accumbens via an indwelling cannula (test 6), Compound A (10 μg) caused a marked (P<0.001) increase in spontaneous locomotion. Amphetamine, at the same dose, was equally effective, but the lower dose of Compound A (1.0 μg) was ineffective, causing a tendency to inhibition, especially during the first 10 minutes after dosing. Direct action of a compound to cause hyperactivity following administration into the mesolimbic nucleus accumbens is considered to be indicative of anti-depressant activity.
In a separate experiment, designed to measure stimulation of the striatum by recording asymmetry and circling behaviour, Compound A (0.01-10.0 μg), apomorphine (up to 50 μg) or amphetamine (up to 100 μg) were administered, unilaterally, via an indwelling cannula into the extrapyramidal caudate-putamen (text 7). Apomorphine and amphetamine were both inactive in this test but Compound A caused marked contralateral asymmetry and circling behaviour which became statistically significant at 1.0 and 10.0 μg.
The results from this test suggest an indication for anti-Parkinson potential for this compound.
D. Anti-depressant activity using the `Porsolt Test`
Compound A, at 0.1-10 mg/kg i/p., showed statistically significant (P<0.05) anti-depressant activity in mice using the Porsolt test, a test measuring the animals ability to keep stable in water. The activity was similar to that of (+) amphetamine (0.625-2.5 mg/kg i.p.) and greater than amitriptyline (2.4-40 mg/kg i.p.). The known anti-Parkinson agent Bromocriptine, 0.1-1 mg/kg i.p. caused a statistically significant reduction in swimming time at the higher dose:
Contrary to the effect seen in this test with the known anti-Parkinson agent bromocriptine, compound A was found to exhibit statistically significant anti-depressant activity.
E. Anxiolytic effect of Compound A
In a study to investigate anxiolytic activity in a `Black and White test box (test 9), Compound A (0.1-10 mg/kg i.p.) caused a statistically significant increase in the time spent in the white section and a correspondingly reduced period in the black area. This behaviour was similar to that caused by diazepam (0.125-5 mg/kg i.p.) and is consistent with other compounds having clinical anxiolytic activity. In a similar, though separate, study bromocriptine (0.1-1 mg/kg i.p.) caused a statistically significant increase in investigatory activity in the black area with no change in the light aversion:
Contrary to the effect seen in this test with the known anti-Parkinson agent bromocriptine, compound A was found to exhibit statistically significant differences in its anxiolytic effect.
F. Anti-Parkinson activity: MPTP-treated marmoset model
(i) Parkinsonism-like motor deficits (hypokinesia and bradykinesia) were induced in marmosets by the intranigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 13 days via an implanted injection unit and osmotic minipump (Test 10). Motor deficits appeared within 3-4 days and persisted for several weeks. Drug assessments were begun after 7-10 days of infusion.
Compound A (0.05-1.0 mg/kg s.c.) fully restored normal motor behaviour, although at 0.05 mg/kg, 1 to 2 marmosets did not respond:
______________________________________Behavioural MPTP Compound A (mg/kg s.c.)measure Control +vehicle 0.01 0.05 0.1 1.0______________________________________LMA 100 15 26 47*(70) 93** 103**(% control)% time spent 30 3 4 12*(23) 29** 28**in LMA% time in head 85 23 26 36*(80) 83** 84**movements______________________________________
LMA-Locomotor activity (movements between perch and cage floor).
Values are means (n=4); S.E.M. <13.6%, except at 0.05 mg/kg. where 1 or 2 animals did not improve (S.E.M. up to 24.2%). Values in parentheses are means from those animals responding.
Significant antagonism of MPTP impairment * P<0.05, ** P<0.01.
The most marked effect of Compound A was the full restoration of normal movements in the limbs, trunk, head and neck. In particular, characteristic rapid side to side head movements returned, as did normal facial expressions and the motor coordination for complex tasks such as jumping and playing. Furthermore, there was no development of tolerance during dosing (0.1, 1.0 mg/kg s.c.) twice daily for 7 days.
For comparative purposes tests were carried out with two known anti-Parkinson agents L-DOPA and Bromocriptine.
Treatment with L-DOPA (12.5 mg/kg i.p. 30 min. pretreatment) after benserazide (12.5 mg/kg s.c. 90 min. pretreatment) also restored MPTP-induced motor deficits, but at these relatively high doses appeared to be less effective than 0.1 mg/kg s.c. Compound A. Treatment with Bromocriptine (0.1 mg/kg s.c.) had little effect.
The results of this specific test confirm the potential of compound A for use as an anti-Parkinson agent.
(ii) Compound A was administered orally to MPTP treated marmosets at doses of 0.1, 0.5 or 1.0 mg/kg.
Partial reversal of the following MPTP-induced motor deficits were recorded following each dose: percentage time spent in locomotor activity, reduction in speed of head movement, reduction in speed of locomotor activity, lack of interest in surroundings, lack of facial expression, head elevation and percentage time spent in head movement. The response for the lowest dose (0.1 mg/kg, n=2) was submaximal and the highest dose (1.0 mg/kg, n=3) was supramaximal. No emesis occured at the two lower doses.
The results of this specific test confirm the potential of compound A for use as an anti-Parkinson agent.
G. Receptor binding studies
Receptor binding studies, using rat brain, indicated that both bromocriptine and pergolide showed affinity for 5HT1 and 5HT2 receptors and pergolide also bound to dopamine D1 receptors. Compound A showed no affinity for any of these receptor subtypes.
These studies indicate that Compound A is more selective in its binding to receptors than the other D2 -agonists (bromocriptine and pergolide) studied.
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It has been a while since Albert Edwards updated the world on his macro and market thoughts. He finally does so today with a tour de force on the crash in the emerging markets, which for him exposes the "idiocy of one of the key investment themes since the 2008 Great Recession – namely that with developed economies burdened with excessive debt and in the throes of multi-year deleveraging, investing in emerging markets would not only produce superior returns but was also less risky. Regular readers will know we have long railed against this idea, having dubbed the BRIC story a Bloody Ridiculous Investment Concept."
He links what is happening now to his "call at the end of last year that the EMs were heading for a balance of payments crisis and would see a currency debacle similar to 1997 was met with total indifference. We still find the same disregard to our call for a renminbi devaluation."
Continuing the litany of vindication, Edwards next observes that the "global economy and markets have been far, far more vulnerable to a resumption of the 2008 crisis than the happy-clappy consensus would have us believe. At the moment, investors think that problems are isolated to a few EM countries that have allowed their current account deficits to get out of hand. I see this as the beginning of a process where the most wobbly domino falls and topples the whole precarious, rotten, risk-loving edifice that our policymakers have built."
Naturally no crash prediction will be complete without some fond reminiscences on the most historic crash of all: 1987. >> Read More