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Former Celtic And NBA Great Has Health Scare
If you ask most people who the best player in NBA history is, you'll most likely hear a lot of nods for Lebron and MJ. While those two are tremendously skilled and both have winning pedigrees, there should be no questioning the correct answer to who is the greatest winner in NBA history. The answer's a lock...Bill Russell.
Celtics' Draft: The Picks Are In
The Red Sox Lost to the Angels-WBSM Monday Sports (AUDIO)
The Red Sox Beat the Indians and Terry Francona- WBSM Wednesday Morning Sports (AUDIO)
Mike Napoli lead a seven-run 2nd inning as the Red Sox beat Cleveland 7 to 2; the Bruins and Celtics get back to work for the first time since the bombing.
Ryan Baldwin Leads Fairhaven in Baseball Win-WBSM Wednesday Morning Sports(AUDIO)
Sox Win Home Opener and the Bruins Beat the Hurricanes — WBSM Tuesday Morning Sports
Daniel Nava lead the Red Sox to a win on Opening Day; the Bruins had an easy time with the Hurricanes; and the Celtics get ready for the Nets.
Middlebrooks with 3 Home Runs-WBSM Monday Morning Sports (AUDIO)
Will Middlebrooks had three home runs to power the Red Sox to a 13 to 0 win in Toronto; Opening Day at Fenway; the Celtics won with Paul Pierce and Kevin Garnett back.
Bruins Win, Red Sox Lose-WBSM Friday Morning Sports (AUDIO)
The Yankees avoid the sweep with a 4-2 win; Jaromir Jagr scores for the Bruins in a 1-0 win; Celtics play tonight.
Red Sox Prepare for Opening Day-WBSM Friday Morning Sports (AUDIO)
The Red Sox have two more games with the Twins before they head north for Opening Day in NY Monday; the Celtics host the Hawks tonight; the Bruins play tomorrow.


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14K yellow gold ring set across the top with caliber-cut rubies and old European cut round diamonds and an oval cabochon ruby bezel-set on each side. Signed "GB," circa 1970. Size 6.
Meriwether McGettigan has been in the jewelry business for more than 30 years. Her unique boutique has the rarefied feel of an elite European club, catering to a global clientele whose tastes run to vintage Tiffany, Lalaounis, Cartier, Verdura, Van Cleef Arpels, and other fine jewelers, as well as spectacular artisanal pieces from around the world. Meriwether frequently lectures on jewelry from the Retro Period (1930s and '40s) and important 20th-century designers.

subset: commoncrawl


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Pets on Santa's nice list and their families can enjoy Santa Paws Is Coming to Town, a holiday party thrown by Paws, Purrs, and Exotics Animal Hospital (133 South Peyton St., Alexandria) and Barkley Square. The party, which takes place at the hospital, will feature photos with Santa, dog and cat adoption with the Washington Humane Society, free snacks and drinks for people, and treats for dogs. The event costs $10 per person and runs from 1 to 4. Proceeds benefit the Washington Humane Society.
The seasonal fun continues at Lucky Dog Animal Rescue's Holiday Party at Your Dog's Best Friends (2000 Jefferson Davis Highway, Alexandria). The event includes refreshments, photos with Santa, and a dog play area. Photos with Santa are $20; the party is $10 per dog, free for people.
It's the second Saturday of the month, and that means Yappy Hour at Chateaux-Animaux's Capitol Hill location (524 Eighth St., SE). Free wine and cheese will be available for people and fresh baked Zanadoo Dog Biscuits for canine companions. A free pet-coaching seminar, courtesy of Doggy Lama, will look at pet safety during the holidays. The Washington Humane Society adoption van will also be on site. The free event runs from 6 to 8.
Sunday, December 13
Capital Cats will bring some of its favorite felines to Chateaux-Animaux (524 Eighth St., SE) for an adoption event from noon to 3.
Still looking for that purr-fect holiday gift? Julie Jordan, "chief critter whisperer" for Newton's Paw will be at Chateaux-Animaux (524 Eighth St., SE) from 1 to 4 making keepsake ornaments from your dog or cat's paw print. Jordan will take the impression in the store and have your one-of-a-kind ornament ready for pickup within a few days. Prices vary, and part of the proceeds go to the Animal Welfare League of Alexandria and YoKids.
The Dog Shop (1625 Wisconsin Ave, NW) in Georgetown will host an adoption event from noon to 2.


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LBL Lighting Veneto 1 Light Inverted Pendant
LBL Lighting Veneto 1 Light Inverted Pendant
Additional Documents
Weights & Dimensions
|Fixture Type: Inverted pendant
|Style: Contemporary
|Shade Material: Glass
|Shade Color: 1: Orange
|Shade Color: 2: Red
|Finish: 1: Bronze
|Finish: 2: Nickel
|Bulb Type: Halogen
|Number of Lights: 1
|Number of Tiers: 1
|Bulb Included: Yes
|Voltage: 120 Volts (V)
|Wattage per Bulb: 150 Watts (W)
|Country of Manufacture: Imported
Still have questions about this product? We're here to help
LBL Lighting Veneto 1 Light Inverted Pendant
About the ManufacturerFor over 40 years, LBL Lighting has built their business on trust. What began as a family business in 1971 has since become part of the larger Generation Brands family. They continue to be one of the recognized leaders in their industry and a premier choice for lighting designers throughout North America. Their eclectic designs and decorative forms each richly saturated with intense color celebrate the functional artistic nature of lighting. Moreover, they accentuate the relationship between glass, art and lighting. LBL Lighting systems are developed with three core values in mind: beauty, originality and quality. Their commitment to each of these principles is evident in all their products, from their new low-voltage pendants to their incredible selection of signature sconces and ceiling fixtures. Their focus on customer service and support continues to grow, and they truly value your business. They are driven to become your most trusted source for quality lighting.
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Tell us what you think about this product. It will help us provide you with better products in the future and help your fellow shoppers make better purchases.Write the first review
OUR SKU # LBL9202Veneto 1 Light Inverted Pendant is also sometimes listed under the following manufacturer numbers: HS317AMBZ2J150, HS317AMSC2J150, HS317MOBZ2J150, HS317MOSC2J150, HS317OPBZ2J150, HS317OPSC2J150, HS317RDBZ2J150, HS317RDSC2J150


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Anne 4-Drawer Chest-Royal CherryItem # HN-SSI673
- Constructed from engineered wood
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Anne 4-Drawer Chest-Royal Cherry
Teach your little girl how to store her clothes properly with the Anne 4-Drawer Chest. Constructed from quality engineered wood in a Royal Cherry finish, this four-drawer chest is well suited for today's needs with plenty of storage room. Profiled corners and moldings add safety and provide a softer look. The drawers are child-friendly - Smart Glides will make them easy to pull, while safety catches prevent them from falling out. Dimensions: 30.8L x 15.7W x 35.8H inche


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Goodbye blazers, hello neoprene motos.
A to Zee: In Good Company
Embroidered silk dress, Balmain, price on request, collection at Maxfield, L.A. Stingray clutch, Jimmy Choo, $2,195, visit jimmychoo.com. Gold earrings, Fiona Paxton, $198, visit shopbop.com. Enamel and resin ring, Chanel, $495, call 800-550-0005. Jet cat's-eye ring, Lia Sophia, price on request, visit liasophia.com. Studded calfskin pumps, Christian Louboutin, $3,595, visit christianlouboutin.com.


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At what mileage should I have the transmission fluid flushed? Me Lex has 72,000 miles and as far as I know has never had the fluid changed. I don't want to push because I LOVE this car!
Lexus » ES300 » 2002 Lexus ES300 » Questions
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2002 Lexus ES300
Lexus Q&AAsk Your Question
2002 Lexus ES300 Question: When to Change Tranny Fluids
Zdaddy, 3.0L V6, Tucson, AZ, December 13, 2010, 14:36
1 Answer
Answer #1ZeeTech December 13, 2010, 16:41Master
There is no given mileage interval. The ATF has to be inspected at every 30K miles. If the fluid's color is changed, has an odor or there is a shifting issue the fluid needs to be changed. On most Lexus the fluid needs to be changed at 60K. Use only the approved ATF.
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Yeah! First Tomato Harvest! Pics
behlgarden(9)August 25, 2011
This is my first harvest, I bought a home and had a late start. Cherry is the first ones to come out, cant wait for 8 other kids of monster heirlooms. Also got eggplant (indian) and green beans with some cilantro! All veggies were well worth the effort!
From First Harvest 2011 From First Harvest 2011
Beautiful. the picture of the eggplants would make a great wall picture. It is just gorgeous! Linda


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Archive - Apr 5, 2011
City Council approves public market in downtown WilmingtonSubmitted by Marissa Jasek on Tue, 04/05/2011 - 11:26pm.READ MORE:
Full story...»
Del Pietro withdraws from Congressional raceSubmitted by WWAY on Tue, 04/05/2011 - 10:12pm.READ MORE:
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Wilmington woman is one of eight victims in New York killing spreeSubmitted by Cacky Catlett on Tue, 04/05/2011 - 9:38pm.READ MORE:
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Marino on Money: April 5, 2011Submitted by WWAY on Tue, 04/05/2011 - 9:22pm.READ MORE:
So you just bought yourself a new car. Congratulations! Now do you know exactly how you're going to go about paying for it? Well don't stress. Our certified financial planner Ross Marino is here with tips on how to handle financing your new wheels, for this week's Marino on Money. Full story...»
LOST AND FOUND: THE TORNADO OUTBREAK OF 1957Submitted by Jerry Jackson on Tue, 04/05/2011 - 8:11pm.
NC State turns to Gottfried as next coachSubmitted by WWAY on Tue, 04/05/2011 - 5:25pm.READ MORE:
Former Alabama coach Mark Gottfried is the new men's basketball coach at North Carolina State. Gottfried took center stage at Tuesday's news conference, but Maryland basketball coach Gary Williams was a hot topic of discussion as well. Click the video to see what Wolfpack A.D. Debbie Yow thinks about Gary Williams. Full story...»
Wilmington City Council considers parking cost hikeSubmitted by Marissa Jasek on Tue, 04/05/2011 - 5:13pm.READ MORE:
It might soon cost you even more to park in downtown Wilmington. City Council is considering raising parking rates. Full story...»
FIRST ON 3: Plea entered on 2010 case involving witness intimidationSubmitted by WWAY on Tue, 04/05/2011 - 4:51pm.READ MORE:
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On tap at tonight's Wilmington City Council MeetingSubmitted by WWAY on Tue, 04/05/2011 - 4:47pm.READ MORE:
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Azalea Garden Tour: Lanzi GardenSubmitted by Tim Buckley on Tue, 04/05/2011 - 4:47pm.READ MORE:
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I am really fun loving. I like to chat and eventually get to know people in person. dont be afraid to be my sunshine and just message me!
Join OkCupid
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Find better matches with our advanced
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25 • Rochester, NY • Woman
I'm looking for
- Men
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- Dec 24, 2012
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- Doesn't have kids, but might want them
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- Likes dogs
- Speaks
- English
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My self-summary
Write a little about yourself. Just a paragraph will do.
What I'm doing with my life
Don't overthink this one; tell us what you're doing day-to-day.
Im getting settled an trying hard to fit it right.
I'm really good at
Go on, brag a little (or a lot). We won't judge.
im really good at sports and im also good at math. Now dont think im geeky because im not;) im also good at other things. you know, besides allthatother stuff.. lets just say you're gonna have to message me to find out;)
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i love james bond! I also love the twilight and hungergames series!
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Think outside the box. Sometimes the little things can say a lot.
the only thing i couldnt do without is you:)
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Global warming, lunch, or your next vacation… it's all fair game.
how people first talk to me. it's a first impression and it important
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Boston bombing suspect Dzhokhar Tsarnaev told his mother that at least $1,000 had been donated in his name in an account set up for him
In a glimpse at Dzhokhar Tsarnaev's state of mind, he told his mother he was getting better, but was struggling to understand what happened
The FBI says 27-year-old mixed martial arts fighter Ibragim Todashev was killed last week during a violent confrontation in his Orlando home
While sharing has improved as terrorism has become a common concern, it remains problematic and complicated by varying national interests and human rights standards
A logical solution would be designating part of a military base — already federal property — to serve as such a location. Accommodations could be made to permit family visits, perhaps once a year, purely on humanitarian grounds. But the burials would be out of sight, out of mind. They would not become sideshows or fodder for political debate.
'If they didn't want [Tamerlan Tsarnaev] in Boston, why did they bring him all the way down here against our wishes?,' a local resident said
Boston Marathon bombing suspect Tamerlan Tsarnaev's body has been buried, according to Worcester, Massachusetts, police who didn't disclose the location
Katherine Russell added New York lawyer Joshua Dratel to her legal team, her attorney Amato DeLuca said Wednesday
Peter Stefan has been called 'un-American' for being willing to handle Tamerlan Tsarnaev' funeral and hasn't found a cemetery willing to bury the Boston bombing suspect
In the video, filmed by former Toronto student William Plotnikov, rebel fighters repeatedly expressed their desire to kill "kafirs," or non-believers


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Washington Huskies
Husky Stadium
Husky Stadium3800 Montlake Blvd. N.E.,
Seattle, WA 98195 Email | Send to Phone*
Capacity72,500 Buy Tickets | 206.543.2200
- *Message and data rates may apply.
Best Seat in the House
- Nestled up to the pristine waters of Lake Washington, Husky Stadium's captivating walls will not disappoint any fan of the game. From Rose Bowl championships to the 1990 Goodwill Games to hosting the NFL's Seattle Seahawks, this stadium defines historic. Take a moment to soak in the tradition of football in the Pacific Northwest as you head into the main entrance to the stadium. It is there that you'll find a statue resting amidst the brick, welcoming travelers and rabid fans alike into its hallowed halls. This statue honors legendary head coach, Don James the "Dawg-father." As you make your way onto the concourse journey over to the visitor's sideline. Find your seat in section 32. It is there that you'll be able to look off to your right and see Lake Washington and, if you're lucky, catch a glimpse of the breathtaking Mt. Rainier. You'll be an integral part of the "Go Huskies" chant that seems to will the Dawgs to victory on any crisp Seattle football afternoon.
- General Info: Because some campuses regulate the sale of Student and Faculty passes, StubHub cannot guarantee the sale of such passes. Please be aware of any restrictions before ordering tickets designated for students or faculty.
- General Info: Seats purchased in lower level sections 1-33, Rows A-E are considered obstructed view due to seating rows starting at field level.
- General Info: Seats purchased in the following areas might have some obstructed views due to stadium roof posts: North Upper Deck: Rows HZ-OZ and South Upper Deck: Rows AZ-GZ.
- General Info: The Lower Level is divided into lower and upper portions by a walkway. The lower portion includes Rows A-Z followed by AA--CC, and the upper portion includes Rows FF-YY.
- General Info: The Bleachers are a General Admission (GA) seating area.
All ages allowed. Children under the age of 3 are not required to have a ticket provided they sit on an adults lap. All children ages 3 and up must have a ticket to enter the Stadium.
No smoking. No video cameras. No glass bottles, cans, thermos in excess of 2 quarts. No picnic baskets or ice chests. No horns of any kind. No sales of unauthorized merchandise. No banners, placards, or leaflets not approved in advance by the IOA Department. Husky Stadium has long been considered one of, if not the loudest stadium in the country. This is in part due to the stadium's design; almost 70 percent of the seats are located between the end zones. During televised games, it has been known to become so loud that the cameras shake.Buy Huskies Tickets »
Year Opened: 1920 | Field Surface: Artificial Turf
Husky Stadium opened in 1920 as a project funded by the students of the University of Washington. With an original capacity of 30,000, the venue hosted its first game Nov. 27, 1920, vs. Dartmouth. Three more expansions, including the addition of roof-covered stands, brought the capacity to more than 59,000 in 1968. The stadium was expanded again in 1987 to seat 72,500 and included the Don James Center, a glass-enclosed area with views of the entire field.
Husky Stadium will undergo a complete renovation starting in November 2011; it will include a new upper deck on the west side, football offices and permanent seats in the east end zone. The Huskies will play their home games at CenturyLink Field, home of the NFL's Seahawks, until returning to Husky Stadium for the 2013 season.
Husky Stadium hosted the 1990 Goodwill Games and was home to the Seahawks for two seasons when a new Seahawks stadium was built.
Husky Stadium ranks among the most scenic stadiums in the country, with views of Mount Rainier, the Olympic Mountain range and Union Bay on Lake Washington and is one of a few stadiums accessible by boat. The UW crew takes fans to and from their boats, with docks adjoining the stadium grounds.
When and where "The Wave" began remains a claim disputed by many and dates as far back as the 1950s. But we do know it became a popular routine at the University of Washington after Halloween 1981, when the Huskies hosted Stanford and All-American quarterback John Elway. A few people have claimed credit for the crowd routine, saying it originally started going from the bottom of the stands to the top, then top to bottom, before some students tried it sideways and it caught on. The Wave quickly spread to Seahawks games and became popular at many sporting events around Seattle shortly thereafter, and, before long, it turned into a worldwide phenomenon.
Washington was not always known as the Huskies; its first known nickname, the Sun Dodgers, was thought to denote negative connotations. Sun Dodger was the name of a student humor magazine and Sunny was its main character. So popular was Sunny that students started calling the team the Sun Dodgers (from 1919 to 1921) and a 3½-foot tall wooden sculpture "Sunny Boy" was fashioned and became the school mascot. The humor magazine was banned from campus by the administration, which sought a new nickname and mascot. During the winter break in 1921, the school adopted Vikings. But when students returned in January 1922, they opposed the name. A student committee selected Huskies later that year.
The Huskies traditionally have had a live Alaskan malamute as their mascot. Washington also has the costumed Harry the Husky. Today the wooden sculpture of Sunny Boy is in the Husky Fever Hall of Fame at the Hec Edmundson Pavilion, the school's basketball arena.
Source: University of Washington
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In-State Priority Varies Across Pac-12
- In-State Priority Varies Across Pac-12
In-State Priority Varies Across Pac-12Recruiting reporter Erik McKinney joins Phil Murphy to contrast in-state recruiting priorities in the Pac-12.
- Scout's Take: LA Opening Regional
Scout's Take: LA Opening RegionalNational recruiting coordinator Craig Haubert joins ESPN's Phil Murphy to break down top performers from the Los Angeles Opening Regional camp.
- ESPN Junior 300 Updated For 2016 Class
ESPN Junior 300 Updated For 2016 ClassNational recruiting coordinator Craig Haubert breaks down movers in, newcomers to and the top 10 of the updated ESPN Junior 300.
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March 29, 2015
Another year gone means that 26 more episodes of OBSESSED! — Seth Rudetsky's always unpredictable web series featuring the best of Broadway — are live on Playbill.com. Here, Seth sits down to remember his favorite half-dozen moments of 2013 including bad auditions, a good audition, "crazazy" old headshots, a belted TV show theme, bad tanning and, of course, "Defying Gravity" sung in several different languages. Read Seth's weekly column. Visit SethTV.com, Seth's online home.
Show Name:
27 Mar 2015
Eden Espinosa Will Join Adam Pascal, Telly Leung, Mandy Gonzalez, Marcus Paul James for Seasons of Broadway
26 Mar 2015
Tony Danza Heads to the Chatterbox Today
23 Mar 2015
Onstage & Backstage: What Happens When Julie Andrews Gets "Over-Tired"?
22 Mar 2015
"Into the Woods" Film Cast Reunites, Along With Broadway Stars, for Sondheim Birthday Concert Tonight
16 Mar 2015
"Into the Woods" Film Cast Reunites Along With Broadway Stars for Sondheim Birthday Concert
"A Les Miz for the 21st century!"- The Huffington Post
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Reporter to Jay Carney: So, how often does the president shoot skeet? Carney: Squirrel!
**Written by Doug Powers
In an interview with The New Republic, President Obama said that he shoots skeet "all the time" at Camp David.
Jay Carney was asked about that at today's briefing, and surprisingly enough, Carney was fairly vague about any details:
A reporter today asked White House Press Secretary Jay Carney how often Obama goes shooting and why hasn't the press corps heard about this before? Carney simply referred her to Obama's statement.
Is there a photo of the president shooting? "There may be, but I haven't seen it," Carney replied. He didn't mention if he had personally seen Obama go shooting.
There may not be an existing photo of President Obama shooting skeet, but I'll bet there will be by the end of the week.
(h/t Weasel Zippers)
**Written by Doug Powers
Twitter @ThePowersThatBe
Jen Psaki sent out to spin the Bergdahl debacle for Obama (Susan Rice apparently indisposed)
March 25, 2015 09:53 PM by Doug Powers
Ayatollah Khamenei: 'Death to America' — White House: Netanyahu sure is dangerous
March 24, 2015 12:28 PM by Doug Powers
Hillary at the White House
March 24, 2015 09:11 AM by Doug Powers
Timing is everything: White House and State Dept attempt to mixed-message Iran into compliance
March 20, 2015 12:10 PM by Doug Powers
Obama admin happy to provide proof of historic levels of transparency, but you'll have to *FOIA it (*expect 3 to 6 decades for delivery)
March 18, 2015 10:12 AM by Doug Powers
Categories: Barack Obama, Politics


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Annie. Just makes her unplayable if you're a self respecting man. Oh and as for Veigar, I <3 him, so much that I bought the leprechaun skin for him. All the haters just makes Veig greater.
Junior Member
Because online games always need more whining.
the announcer. hurray for lack of enthusiasm.
Adepta Sororitas
Tristana. DID YOU FALL DOWN AND GO BEWN!?!?!?!?
Senior Member
I cannot bring myself to try Yi because I hate his voice so much.
Ryze has one of my favorite voiceovers in the game.
get rekd fgt
Is this a joke?, have you seen a spamming Lux? with the laughing and the spamming of her audio for her basic attack.
I mute everytime.
Arya Starck
Lux : HEHEHE AHAHAH TEE HEE HEHEHEH HEE HEE TEEE HEEE AHAH!
he he he he !!
tee hee !
aha haha ha !
hee hee !
The only problem with Nasus is he is so loud! first time I played him when he spoke I almost fell outta my chair and I hadn't messed with the sound at all.
Veigar is SUPPOSED to be annoying. He's hilarious. Voices that are so bad their good, ya know?
I don't think I have any single champion I hate solely based on bad voicing. Most champs have a good voice in my opinion. Now there are bad LINES for sure. Also, the majority of champions all seem to have a terrible laugh, regardless of how decent their voice is. EVERYONE hates lux laugh.
© 2015 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


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Use Devextreme and Visual Studio to create a basic mobile app.
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Working with Serialized JSON Data in Windows Phone 8 Apps
Vipul Patel shows you how to work with serialized data (in JSON format) in Windows Phone 8 applications.
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Have you ever wanted to control your garage door from your smartphone? Here is your chance. Get your hands dirty with an Arduino Garage Door Controller.


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Venison Jerky, HELP!
I have been put in charge of doing a whole bunch of venison into jerky. I have a Masterbuilt electric smoker & a 22'' Weber kettle. I plan on using the MB because I'm broke & can control my temps better. Just wanted to see what some of have used & could use any advice. We don't have a jerky gun so I was thing of just cutting a ton of medallions but we do have a grinder so I could use that too. Any ideas on anything would be appreciated(wood, spices, marinades, etc.) I think I have oak, maple, cherry, hickory & mesquite chips.
There are many commercial jerky mixes (IE: Hi-Mountian) that have a curing agent. Adding your own ingredients like Worcestershire or Soy Sauce, garlic powder, or red pepper.
I lightly freeze the meat and then slice at 1/8" on the meat slicer and set in 2 lb piles. Soak a few stacks in separate bags overnight, set on racks and dry until tacky. I then cold smoke for 2 hours using only an A-Maze-N Pellet smoker before turning the heat up to 110 to slowly dry the final product. I use whatever pellets on hand Apple/Cherry/Hickory and sometimes mixtures.
The other packages I keep refrigerated or frozen until time permits adding the curing liquid mixture 1 day before drying and smoking.
Cool each batch to room temperature after you have dried it out and Vac-seal into useable package sizes and distribute.
Thanks Madman I will that a go on one of the batches, Any other ideas people? We are going to grab some Hi-mountain or the like but am trying to get a few different ideas & make a bunch of different jerkys.
Smoke Dawg makes some good looking jerky in his smokehouse. It is beef jerky but same basic principle.
This. Having a meat slicer (deli slicer) helps tremendously. Seriously, if you can beg one off a friend/bar/business that you frequent you will have much, much better results than trying to cut slices by hand (also it is a huge pain in the arse to do so). Your slices will all be the same thickness and you won't have to monitor your cooker as much. You can bone out (if this is not already done) all the hindquarter roasts whole and slice them up in no time.
As an aside, if you make jerky out of your backstraps it is a crime in most states.:ban:
If you don't have cure #1 use Morton's Tender Quick in its stead. You can find it in your spice aisle of your grocery store. It has nitrate and nitrate in it.
I soak mine in my brine for two days then cold smoke until dried. Seems to work well. People eat em like potato chips.
What is cure#1? Hell no I'm not using the backstraps for jerky!!!! We just cut up a (220# hanging) buck & a 180#er. I'm doing about 10# this time but we have another week & 2 tags to fill plus bowhunting till the en of the year.
I seriously have seen people on the forum talking about making their backstraps into jerky....for shame! Those are some good sized bucks you got there. Good luck with the jerky.
These should be a must have...... I wish I had looked sooner, and saved me years worth of slicing work (LOL).
I have made a tone of venison jerky on a cheap Big Chief electric smoker.
Really love the High Mountain Jerky Cure tastes great and really easy to use.
Good luck.
Funny you bring up a meat slicer, i just sold mine on CL 2 months ago. Moving & broke! I picked up some Tenderquick & Hi-Mountain Bourbon BBQ blend. Going to get them marinaing tonight or in morning. Smoke either Friday or Saturday. Thanks fo the tips, keep'em coming!
Just curious... Any jerky makers here Follow the USDA guidelines of simmering the meat to 160* IT before drying or 10 mins in a 275* oven after the drying? E Coli not being killed...
I just read about it myself tonight and do not plan too... still made me pause because I never considered it before...
(From field dressing to freezer I personally do every step so I am comfortable that fecal matter does not get on the meat... )
Sorry I missed this. Just hand slice the meat. use any basic salt brine and soak overnight. I do use tenderquick in mine and add some brown sugar and garlic powder. Next day I rinse and then soak in teryaki sauce (at least a couple hours and up to overnight) and hang the meat (you can just lay it on the racks if needed) sprinkle course black pepper or red pepper and smoke at 120° - 150° until done ~ 4 hours. I like to use maple or alder and usualy a mix.
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Student: MAURISHA BOWERS Assignment score: 100% Total Time spent: 16 minutes, 6 seconds 1. Your answer: 2. Your answer: 3. Your answer: 4. Your answer: Assignment: Homework Chapter 04 Score for selected take: 100% (20/20) Time spent on selected take: Immediately after the Revolutionary War ended, the form of government established by the Articles of Confederation in the United States was a. communist. b. confederal. c. federal. d. syndicalist. The system of checks and balances set forth in the U.S. Constitution allows a. the executive branch to dominate all the other branches. b. each branch to limit some actions of the other branches. c. the legislative branch to determine which cases are reviewed by judges. d. the judicial branch to have the final say on any issue. The commerce clause of the U.S. Constitution authorizes a. the judicial branch to regulate commerce. b. the executive branch to regulate commerce. c. the legislative branch to regulate commerce. d. the states to regulate commerce and foreign trade. The federal government has the constitutional authority to regulate all business enterprises a. in the United States that are involved in interstate commerce. b. that are located in North America. c. that are involved in international commerce. d. that are not involved in interstate commerce. Page 1 of 4 Homework Chapter 04 8/29/2010 http://cvg.cengagenow.com/ilrn/takeAssignment/viewAssignmentPrintableMain.do?assign... 5. ... View Full Document
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30-Day Plank and Push-Up Challenge
By Teresa M. Howes
Skip the crunches and put your weights down. Get down into plank and push-up positions to sculpt and tone your body.
Whether you're looking to outfit yourself for your next big race or get the latest hiking gear for your next camping adventure, find all the essentials and more with this gear guide.


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Tag Archives: volunteer
The 2015 Special Olympics World Summer Games are coming to Corona! That's right, this summer Corona will welcome and celebrate nearly 100 athletes and their coaches from around the world for a special three-day Host Town program that will take place prior to the opening ceremony of the Special Olympics World Summer Games in Los Angeles that are held July 25, 2015 to Aug. 2, 2015.
A new website has recently launched, JustServe.org, to provide a place where every organization and individual can go to find service projects in the local and surrounding areas. Think of it as a matchmaking service to help pair people with the needs of community service agencies and organizations.
On Nov. 13, 2014, the Corona Police Department hosted the 2014 Annual Volunteer Appreciation Dinner at the Corona Public Library Grand Blvd Room. The dinner honors and recognized over 100 police volunteers who provide thousands of hours of service to the department and the community. The volunteers serve in various areas of the police department and are separated in different volunteer groups
The Bicycles for Children organization, a local not-for-profit, was founded three years ago with the goal of donating 155 bicycles to impoverished children to the Corona/Norco Unified School District. This year, the Bicycles for Children organization set an ambitious goal of donating 700 bicycles.
Do you want your family to be better prepared for a disaster? Do you want to assist in our public safety agencies with Emergency Communications? Do you want to be licensed to use more powerful radios for communication in the desert or the mountains? Or perhaps you just want to learn something new.... Continue reading...
Food Runners second Annual 5k Fun CanRun to support the Corona Norco Settlement House. The 5k Fun CanRun will be collecting cans in lieu of a registration fee.
After last year's Run saw huge success with more than 500 people participating at the event and more than 3,200 pounds of food collected, Food Runners is doing it again!... Continue reading...


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GBH Pony Club Pace- November 16, 2014
Please join Golden's Bridge Hounds in supporting the GBH Pony Club. This organization produces knowledgeable and responsible horseman of the future. We love seeing our pony clubbers out in our hunt field and enjoy supporting their equine endeavors.
click here for more information and to download forms:
Contact information:
Lauren Ivanhoe


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Winnipeg Free Press - PRINT EDITION
For the BIRDS
Classes teach owners of fine-feathered friends not to treat their pets like dogs
Birds aren't dogs. And while bird lovers may order their birds to sit and obey, this may -- literally -- come back to bite them.
A popular training method that focuses on dog-pack mentality may be causing harm to pet avians. And rather than merely complain about a problem, a local bird expert is doing something about it.
Melanie Shura, the president of Avian Welfare Canada Inc., predicted this training trend could be destructive to birds. She feared people would try to use pack-leader training on them and she was right. Shura said she's seeing a large spike in two- to four-year-old birds requiring her assistance.
"It's an alarming trend," she said.
Some birds come to her with psychological damage. It may take "weeks or years to overcome," she noted. Shura has seen many bird relinquishments. They typically stem from an allergy to a family move -- or other life-related issue. Recently, many birds come to her because of behaviour issues. And most of these are caused by human error.
It's one of the main reasons she's excited to partner with the Winnipeg Humane Society to offer bird workshops. Shura's goal is to "reach more people."
Not only does she wish to work with bird lovers, but pet-trade workers, veterinarians and vet technicians, too. She wants to spread the message that the "I'm the boss" method doesn't work with birds. Instead, she seeks to encourage others to embrace behaviour modification methods that are "the most effective and least invasive," she said.
The classes will be broken into different sessions. They will cover many things, from care and environment to understanding communication and behaviour. Class participants will even be given homework to practise the methods taught in class. The end goal, however, is to prevent pet bird relinquishment and encourage a greater relationship between birds and their caregivers. Trust is key and it's not developed through negative reinforcement or pack-leader mentality.
While Shura's form of training is scientifically proven to work, it also takes time and patience. Therefore, it's vital that you have time to train a bird, should you choose to adopt or purchase one. It isn't the right pet for someone who wishes to tuck it in a corner and ignore it. Because some species can live as long than humans, birds are a big commitment. It's why her classes make so much sense.
Mistakes with a bird often begin the day it's purchased. Many people buy them on a whim. Who can blame them? Birds are beautiful. Society has taught us to expect our feathered friends to sit nicely on a perch or sing songs the minute they are placed in a cage. We often forget that they're complex, intelligent creatures.
Just because "a bird is hand-fed doesn't mean it's tame," said Shura. She explained that there are more than 300 species of parrots. Each species has different needs. Consider how they bathe in the wild: some prefer bathing in puddles, others like to be misted. These simple differences need to be addressed at home to ensure the bird is happy. The rule of thumb is to understand their natural habitat and mimic that in their home life.
Another habitat-related example can be seen in the budgie. You'd expect smaller birds would require a small cage. This isn't the case. In the wild, Shura explained, these sweet birds fly a great deal. As a result, they require more space -- at least a 21/2-foot cage.
"A bird cannot be happy if its basic needs are not met," she said. Like other creatures, these needs include environment, nutrition and exercise. When birds are unhappy they act out; they can even bite.
Even if their needs are met, birds can behave in a negative manner. Bad behaviour is learned. For instance, Shura explained, if a bird is yelled at every time it screams, that bird learns to continue screaming. It assumes you're just joining in. However, if we reward the bird for quiet behaviour it will learn that this is the preferred way to act.
When I interviewed Shura, she inadvertently offered an example. While we chatted, her bird, Lily, was quietly making noise. As Lily did this, Shura would praise her. At the same time, a cockatoo, which she was bird-sitting, was eager to let its loud voice be heard. Shura noted that to train that bird, she'd have to find opportunities to reward good behaviour. Lily's lovely greeting of "hello" would be reward enough for any avian enthusiast's patience.
The first step to having a well-behaved, happy bird is to understand these lovely creatures. You might not be the boss of your bird, but with Shura's help, you'll discover how to be a competent, knowledgeable bird lover.
Feather your
knowledge nest
Available classes:
Intro Small Birds: Budgies, Cockatiels, Lovebirds
May 3, 6:30-8:30 p.m.
Registration Fee: $5
Intro Medium and Large Parrots
June 7, 6:30-8:30 p.m.
Registration Fee: $5
Parrot School: Behavior I
June 12, 19 and 26, 6:30-8:30 p.m.
Registration Fee: $125
To register, call: 982-3555
All classes will be held at The Winnipeg Humane Society, 45 Hurst Way
Also, varied species, including cockatiels, are up for adoption through Avian Welfare Canada.
For further information on these classes (or future ones), the newsletter, adoption or avian welfare, contact:
Republished from the Winnipeg Free Press print edition May 1, 2012 D6
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- I worked with Ed Cornish and Alex Prior one afternoon creating traditional woodblock style type out of potatoes. It was a fun project, we liked the idea that you could print with anything you could lay your hands on. We
printed typographic mother's day cards to raise money for our final degree show as well as an A-Z collection of our letters.


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GOODYEAR, Ariz. (AP) — Anthony DeSclafani struck out nine in six impressive innings, pitching the Cincinnati Reds to a 5-0 win over the Texas Rangers on Wednesday night.
Posts Tagged By GARY SCHATZ
GOODYEAR, Ariz. (AP) — Brandon Moss showed off the power that persuaded Cleveland to trade for him, hitting a three-run homer against Ryan Vogelsong that helped the Indians beat the San Francisco Giants 9-5 on Tuesday night.
GOODYEAR, Ariz (AP) — Josh Satin, competing for a spot on the Reds bench, hit tying three-run homer in the eighth then singled in the winning run an inning later, lifting Cincinnati to a 4-3 victory over the Oakland Athletics.


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- Forum: Current Mac Hardware
interesting though is reports (probably a few years ago now) that the best PC laptops were macs, why not use the best hardware you can get your hands on. I would struggle with any more microsoft products on my machine than absolutely necessary, but at least the consistency of hardware makes the mac a good platform to run windows on. We run approx 50 windows on macs machines in our autocad drafting dept, for exactly that reason


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A popular flowering tree for southern landscapes with beautiful, glossy, dark green leaves. Fragrant, white flowers appear in late spring and continuing sporadically throughout summer. An elegant tree with year round interest.
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Freight train hits semi on Montana Hi-Line
HELENA, Mont. (AP) -- A freight train with its whistle blowing derailed Tuesday in northeastern Montana after colliding with a semitrailer that had pulled across tracks at a private crossing between Bainville and Culbertson, a BNSF Railway spokesman said.
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Was Denver Right For Tebow?
Donavon Murphy | On 14, Jan 2013
I couldn't help but to reminisce on Tim Tebow's game winning drive in overtime against the Pittsburgh Steelers last year, as I watched Justin Tucker's kick seal the deal for the Denver Broncos impressive season.
The Baltimore Ravens put an end to a stellar comeback season for Peyton Manning and for the streaky Broncos. Before Saturday's defeat, the Broncos had won their last 11 games.
Let me take you back a bit. Around this time last year, the Denver Broncos were in similar situation.
However, they were dealt a different judgement with quarterback Tim Tebow.
In the AFC wild-card game last year; Denver versus Pittsburgh, Tebow had his magician hat on tight.
He connected with Demaryius Thomas on an electrifying 80-yard touchdown pass on the first play of overtime and the Broncos defeated the stunned Pittsburgh Steelers 29-23.
Here's where the magic comes in; the drive only took 11 seconds. The longest overtime postseason touchdown in NFL history.
Tebow racked up a list of accolades for his historic performance.
- He was the first NFL player ever to complete four passes of 30 yards or more in a single quarter of an NFL playoff game, with 51, 30, 58, & 40.
- His passer rating was 125.6, the highest in Broncos playoff history.
- He finished with 316 yards passing with a pair of touchdown passes and no interceptions. He also added 50 rushing yards on 10 carries with another touchdown. According to Elias, he's the third quarterback in the Super Bowl era to throw for 300 yards without an interception, and run for a touchdown in a playoff game.
That year wasn't too shabby for Tebow. I mean it wasn't boisterous, but it wasn't that bad.
While the buzz around Tebow was growing, the Denver Broncos organization had something else on the menu. They pursued high profile free-agent, Peyton Manning, leaving Tebow in the dark.
The Denver Broncos and Tim Tebow parted ways. This is where I believe his downfall began.
Now I get it, the Broncos wanted to win and they wanted to win big. They wanted to rush success instead of building a franchise. No pun intended, but they won't be able to do that with Manning. He is simply past that stage.
On top of not "building a franchise", they also hurt a young ego; Tebow. Just imagine how he felt going from getting his feet wet in the league to being shipped like property.
I think the Broncos organization could have approached the situation with a little more sensitivity. Maybe by informing Tebow that Manning would be brought in so he could benefit from a proven star at his position in his early years, Denver could have been a duel-threat QB team this year. I'm just saying.
It's crucial to establish confidence in players, especially at the quarterback position. Tebow's days are growing darker, this season with the New York Jets was no exception.
I guess I'll just continue to ponder on if things would be different for Tim if things had gone differently in Denver.


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started a bottle tree with blue beer bottles
am collecting bottles lol since I don't drink I have to depend on others
Image link:
Great start!!! Is that a metal tree?
Looking good! Love blue glass in the garden!
I snagged a couple of blue bottles at the recycling center the other day, you have to wait till they aren't looking cause they won't let you have them. Blue is so hard to find. I might take up drinking moscato for the blue bottles lol!
Tally HO!
I have the guy at the dump saving blue bottles for me. I trade him Coke box codes. He's come up with quite a few. He even saves odd other items that are blue. Sometimes it's overkill, but I still appreciate his enthusiasm!!!
Let's have a wine drinking party ! Colored bottles only .
hehee . I planted a "log" today ,too ! It's going to be my bottle tree.
The beer in those blue bottles is actually really smooth and quite good--but it is 6% even tho it's a light beer! One at a time with pizza is enough for me!
If you are a wine drinker, Reislings come in blue bottles. I get really tall blue bottles of Falkenburg Reisling at Sam's Club. Red ones are scarce as red has been expensive to make; it takes gold to get that color.
I get blue bottles at the recycling center also, they are set aside and left in a section of "free stuff". Lately there haven't been many for the taking, tho, I think demand is way ahead of supply!
I think a party is a great idea, we really need to drink more so we can get more bottles!
Very nice bottle tree in-the-making Trashydj!
I could attend a wine drinking party, toomuchglass! Absolutely, and only interesting colored bottles!
I have a 6 pk of that "beer" (if you want to call it that). It's nasty even for a light beer. I opened one bottle, took a swig, passed it to Hubby who did the same, and we both agreed the only thing to do was pour the rest of the contents down the drain. I need to pour out the remaining bottles and add them to my bottle borders around my perennial beds.
Slug bait maybe, Jenny, but I wouldn't eat bread or soup made with that disgusting stuff! It's truly vile!
Actually a few years ago I tried the slug bait cure (with *good* beer - wasted a couple bottles of Killians red) but didn't find a single drowned victim and the slugs devoured my lupine. :-(
Looks like you're off to a good start!
I finally caved & gifted an occasional beer drinker with a 12 pack of the blue bottles. Yeah...that stuff is n.a.s.t.y even with pizza. My bottles were returned a few wks later with the comment, "Hope you have enough for your tree cuz I'm removing my name from the donation list."
A neighbor has a small, bush shaped tree out front in an otherwise formal looking bed. Strangely, it doesn't look out of place. I want to ask what she used for the 'tree' but every time I catch her outside she's on the mower. TFS.
My bottle tree is made like yours but is taller.
I used rebar for bottle holders. And like you I
have just started putting it together. Have been
saving donated vodka bottles for several years, And
other odd bottles that I found.
Now that they have the blue beer bottles, I bought
four 12 packs (and I don't drink beer) been giving
it to a friend who will drink it. My tree will hold
83 bottles, And the post is painted a medium blue.
I need to cut 23 more pieces of rebar before I can
finish it.
I have one of those wallpaper scorer thingys, then I soak the bottle. But it is good to remove the labels cuz I was lazy and didn't for my bottle tree and it's been three yrs and the labels DO NOT wear off on their own!!!!
I have lots of blue bottles just can't decide how and especially where to use them. Everything feels unsettled becuase we are going to build a new larger garage and are not in agreement about where its going on our property! I like seeing what other people are doing.
I've been lurking for quite awhile, but this is my first time posting . . . I have 5 bottle trees in my yard and wanted to do an all blue bottle tree. I found actual blue glass (not painted) bottles at my $1 Store filled with sparkling water. Just an idea/suggestion other than bud light bottles.


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The rules regarding the shapes of bullish chart patterns are strict.
A solid cup-with-handle pattern must take a minimum seven weeks or more to form. A flat base needs at least five weeks.
View Enlarged Image
Seven weeks for a cup? What's wrong with four or five?
The answer: time. Before a true market leader stages a breakout and runs to new highs, it needs time to weather market pullbacks and profit-taking by some shareholders. The stock needs time to bottom out and regain upward price momentum before getting in the right position to rally to new highs.
In its research of major market winners over the decades, IBD has discovered many of the best stocks built cup patterns that took months or even more than a year to form.
So, what if you find a cup pattern that's only three, four or five weeks in length? You might have just spotted a subtle topping pattern.
This sell signal, called "sharp pullback and recovery to new highs" and first introduced at IBD's Chart School workshops, constitutes one of 11 offense-related sell signals that help you nail profits near the top, even while the stock is rising.
There are several varieties of this pattern. After a long run-up, a stock might fall hard for two straight weeks, then rush higher the next two weeks to new highs before eventually peaking.
In some cases, it might be three weeks down, three weeks up. Or simply one big weekly drop and two big weeks up.
No matter what the combination, you're trying to spot excessively volatile action.
A sharp pullback, followed by a fast surge to new high ground, suggests that some late fund managers and individual investors are desperately buying shares and throwing caution to the wind. While it's nice to see a stock shoot quickly back to new highs, the resulting V-shaped base pattern tends to bear a higher risk of failure.
In contrast, a sudden run-up after a breakout from a sound base is exactly what you like to see.
Let's say you're viewing a 13-week cup base with a handle that formed near the cup's high and slants gently lower. The handle action indicates that the few remaining frustrated shareholders who bought at high prices have finally exited the stock. When an investor with deep pockets suddenly starts to buy shares heavily, the spike in demand sends the price screaming higher.
Medical giant Johnson & Johnson (NYSE:JNJ) announced Friday that it has entered into a collaboration with tech titan Google to develop surgical robotics. The companies' press release didn't give many details, but said that J&J's Ethicon device business and Google (NASDAQ:GOOGL) will "bring ...
The maker of the da Vinci robotic surgery system said non-GAAP diluted Q4 EPS fell to $4.92 per share from $4.98 in the same quarter a year earlier, topping estimates. Intuitive Surgical's (NASDAQ:ISRG) revenue grew 4.9% to $604.7 mil, beating views of $588.4 mil. During Q4 sales of the recently ...
Stocks hit fresh session highs late Thursday and were on track for a fourth straight gain. Helped by Internet and computer hardware stocks, the Nasdaq rallied 1.1%. The Dow Jones industrial average and the S&P 500 were each up 1%. Volume was tracking modestly higher on both major exchanges in ...
Francis Pulizzi wouldn't think of scrimping on his pets' health care, even if it's a bit pricey. The New York City native and owner of three Chihuahuas figures that he spends a minimum of $300 each time he takes one of the dogs to the veterinarian. A recent visit to the vet for his 9-month-old ...
Regeneron Pharmaceuticals reported solid Q4 sales, but the big cap biotech's stock reversed lower Tuesday as its potentially huge new cholesterol fighter was in the crosshairs of a leading pharmacy benefit manager (PBM). At the JPMorgan Healthcare Conference in San Francisco, Express Scripts ...


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Stretch silicone pot stand in green
Item No.3310099608
The unique design of the 'Stretch' trivet from Joseph Joseph can be easily adjusted to provide space for more than one pan, or even a single large casserole dish. After use, it folds neatly away for convenient storage. Made from a high-quality silicone-nylon composite, it is heat resistant up to 340C/640F.
This item is available for
UK Home Delivery Free (UK orders over £30) or £3.99
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- Dimensions (closed): 1.5 x 21 x 5cm
- Nylon
- Silicone feet
- Protects surfaces from burns and scratches
- Expandable design for a variety of hot pans or large dishes
- Non-slip, non-scratch feet
- Folds neatly away for convenient storage
- Wipe clean with a damp cloth
- Heat resistant up to 240 C/464 F
- These goods were on sale at the highest price from 22.04.14 to 28.04.14. Sold at the reduced price since 29.04.14.


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Jackson, MS—Speaker of the House Philip Gunn recently appointed Rep. Joey Hood (District 35) to the Vice Chairman position of the … Read more
In our community
God's Love
By Francie Hemphill
God's love is like a sweet melody, it quenches the uneasy mind when you take time to listen to the simplicity of what the words are saying. Thank you Heavenly Father for all the great … Read more
Choctaw County basketball returns to action this week
By Austin Bishop
The Choctaw Plaindealer
After a week that saw the Choctaw County High School boys and girls teams play just a little more than a quarter of basketball between them, the … Read more
Calendar of Events
Movie Night at FCA Feb. 8
The Class of 2015 will be hosting an "FCA Movie Night" on February 8 at 7 p.m. at the … Read more
Civil War – Letters about Choctaw County Men
Submitted by C.J. Johnson
Originally published in the Plaindealer in January 1974, two letters were provided with family pride by Mrs. Laura Franks Crenshaw, a resident of Ackerman and long-time native … Read more
Kosciusko VA clinic moves to new location
The VA clinic in Kosciusko moved to a new location in January 2014. A grand opening for the new space is scheduled for Wednesday, February 12 at 2:00 p.m. The public is invited to attend. The location of the new … Read more


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(Click a flag to translate.)
Pizza orders and Lunch Lady - check out School Events page
School Registration- get the paperwork done at home!
Public Skating
Brian Kilrea Arena (Canterbury) has free public skating Saturdays and Sundays from 2:00-2:50pm until the end of March
Hawthorne Community Cupboard
Thursdays - 8 am - 2:30 p.m.
clothing items, shoes, boots, winter gear, as well as some food, books, and toys
Enter from St. Laurent
Click here to see the CBC interview
New Health Curriculum. Click here to get more information
|Superintendent of Instruction: Nadia Towaij
Area Trustee: Bronwyn Funiciello (ZONE 6)
The 2013-2014 Elementary School Calendar can be found here.


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Offered here is this earth tone hand decorated pitcher vase by Knodgen Keramik, formerly known as Ilkra. The form number for this full bellied piece is 2553/25. The satin matte glaze is a beige cream color, with chocolate decoration. It measures 25.7cm ( 10 1/8") high and has a diameter of 21cm ( 8 1/4"). The base is marked as shown. Not many of these pieces to be found.
There are no chips, cracks, fleabites or repairs.
Thanks for stopping by. Always happy to combine items to save on shipping.
We ship WORLDWIDE, please e-mail for shipping costs.
Item ID: RLP-688
Another shopper has this item in their Cart or Wish List.
Specializing in pottery, china and glassware from the Canadian prairie


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'Silver Linings Playbook' Q&A Highlights (Video)
The outstanding ensemble behind the SAG and Academy Award-nominated "Silver Linings Playbook" participated in a Q&A to discuss working on the film.
'Silver Linings Playbook' Q&A Highlights (Video)
The outstanding ensemble behind the SAG and Academy Award-nominated "Silver Linings Playbook" participated in a Q&A to discuss working on the film.
Watch a Live Q&A With Jessica Chastain From 'Zero Dark Thirty' Today (Video)
Golden Globe winner and Oscar nominee Jessica Chastain sits down with the SAG Foundation on Thursday to discuss her career and her performance in "Zero Dark Thirty."
GLAAD Announces Nominees for 2013 Media Awards
"Smash," "Modern Family," and three Ryan Murphy shows recognized in TV; "Perks of Being a Wallflower" and "Best Exotic Marigold Hotel" among film noms.
Jessica Chastain and Kathryn Bigelow's 'Secret Mission' (Video)
Oscar nominee Jessica Chastain, Oscar-nominated for her role in "Zero Dark Thirty," says that upon reading the script for the latter, "I knew from page two that I had to be a part of this film."
Can Hugh Jackman Beat Daniel Day-Lewis for Best Actor?
Three reasons why the "Les Miz" star Hugh Jackman might walk off with the gold over Daniel Day Lewis for "Lincoln."
Watch a Discussion with the Cast of 'Argo'(Video)
Watch the video , where the trio, who are nominated for best ensemble at the SAG Awards (Arkin is also individually nominated in supporting actor), discuss getting their SAG cards, bad auditions, and playing real-life individuals.
Best Social Media from the Golden Globes
The photos and tweets that made us laugh from the Globes ceremony
'Argo,' 'Les Miz' Big Film Winners at Golden Globes
The HFPA's 70th Annual ceremony brings out the stars
'Girls' Creator-Star Lena Dunham: Auditions are Like 'Internet Dating'
The writer, director, producer, and star of HBO's "Girls" opens up about avoiding auditions, the value of improv, learning to act through directing, and more.
'Argo' Takes Top Prize at Critics Choice Awards
The Critics Choice Awards are presented by film journalists, not Academy voters. And their choice this year to include best film and acting categories in comedy, action, and sci-fi/horror suggest they were more focused on bringing in big stars than anything.


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The polycomb protein MEL-18 has been proposed as a tumor suppressor in breast cancer; however, its functional relevance to the hormonal regulation of breast cancer remains unknown. Here, we demonstrated that MEL-18 loss contributes to the hormone-independent phenotype of breast cancer by modulating hormone receptor expression. In multiple breast cancer cohorts, MEL-18 was markedly downregulated in triple-negative breast cancer (TNBC). MEL-18 expression positively correlated with the expression of luminal markers, including estrogen receptor–α (ER-α, encoded by
Jeong-Yeon Lee ... Young-Ha Oh, Gu Kong
Adoptive transfer of tumor-reactive T cells can successfully reduce tumor burden; however, in rare cases, lethal on-target/off-tumor effects have been reported. A noninvasive method to track engineered cells with high sensitivity and resolution would allow observation of correct cell homing and/or identification of dangerous off-target locations in preclinical and clinical applications. Human deoxycytidine kinase triple mutant (hdCK3mut) is a nonimmunogenic PET reporter that was previously shown to be an effective tool to monitor whole-body hematopoiesis. Here, we engineered a construct in which hdCK3mut is coexpressed with the anti-melanoma T cell receptor F5, introduced this construct into human CD34 cells or PBMCs, and evaluated this approach in multiple immunotherapy models. Expression of hdCK3mut allowed engrafted cells to be visualized within recipient bone marrow, while accumulation of [18F]-L-FMAU in hdCK3mut-expressing T cells permitted detection of intratumoral homing. Animals that received T cells coexpressing hdCK3mut and the anti-melanoma T cell receptor had demonstrably higher signals in HLA-matched tumors compared with those in animals that received cells solely expressing hdCK3mut. Engineered T cells caused cytotoxicity in HLA/antigen-matched tumors and induced IFN-γ production and activation. Moreover, hdCK3mut permitted simultaneous monitoring of engraftment and tumor infiltration, without affecting T cell function. Our findings suggest that hdCK3mut reporter imaging can be applied in clinical immunotherapies for whole-body detection of engineered cell locations.
Melissa N. McCracken ... Jerome A. Zack, Owen N. Witte
Toidi Adekambi ... Susan M. Ray, Jyothi Rengarajan
Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma development; however, the epigenetic mechanisms that are involved in metastasis are not yet clear. Here, we analyzed 2 syngeneic primary human osteosarcoma cell lines that exhibit disparate metastatic potential for differences in epigenetic modifications and expression. Using methylated DNA immunoprecipitation (MeDIP) and microarray expression analysis to screen for metastasis-associated genes, we identified Iroquois homeobox 1 (
Jinchang Lu ... Jingnan Shen, Jin Wang
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA methylation. DNA methyltransferase inhibitors (DMTis) are used to treat these disorders, but response is highly variable, with few means to predict which patients will benefit. Here, we examined baseline differences in mutations, DNA methylation, and gene expression in 40 CMML patients who were responsive or resistant to decitabine (DAC) in order to develop a molecular means of predicting response at diagnosis. While somatic mutations did not differentiate responders from nonresponders, we identified 167 differentially methylated regions (DMRs) of DNA at baseline that distinguished responders from nonresponders using next-generation sequencing. These DMRs were primarily localized to nonpromoter regions and overlapped with distal regulatory enhancers. Using the methylation profiles, we developed an epigenetic classifier that accurately predicted DAC response at the time of diagnosis. Transcriptional analysis revealed differences in gene expression at diagnosis between responders and nonresponders. In responders, the upregulated genes included those that are associated with the cell cycle, potentially contributing to effective DAC incorporation. Treatment with CXCL4 and CXCL7, which were overexpressed in nonresponders, blocked DAC effects in isolated normal CD34+ and primary CMML cells, suggesting that their upregulation contributes to primary DAC resistance.
Kristen Meldi ... Valeria Santini, Maria E. Figueroa
Parkin and the glial cell line–derived neurotrophic factor (GDNF) receptor RET have both been independently linked to the dopaminergic neuron degeneration that underlies Parkinson's disease (PD). In the present study, we demonstrate that there is genetic crosstalk between parkin and the receptor tyrosine kinase RET in two different mouse models of PD. Mice lacking both parkin and RET exhibited accelerated dopaminergic cell and axonal loss compared with parkin-deficient animals, which showed none, and RET-deficient mice, in which we found moderate degeneration. Transgenic expression of parkin protected the dopaminergic systems of aged RET-deficient mice. Downregulation of either parkin or RET in neuronal cells impaired mitochondrial function and morphology. Parkin expression restored mitochondrial function in GDNF/RET-deficient cells, while GDNF stimulation rescued mitochondrial defects in parkin-deficient cells. In both cases, improved mitochondrial function was the result of activation of the prosurvival NF-κB pathway, which was mediated by RET through the phosphoinositide-3-kinase (PI3K) pathway. Taken together, these observations indicate that parkin and the RET signaling cascade converge to control mitochondrial integrity and thereby properly maintain substantia nigra pars compacta dopaminergic neurons and their innervation in the striatum. The demonstration of crosstalk between parkin and RET highlights the interplay in the protein network that is altered in PD and suggests potential therapeutic targets and strategies to treat PD.
Durga Praveen Meka ... Konstanze F. Winklhofer, Edgar R. Kramer
Liver cholestatic diseases, which stem from diverse etiologies, result in liver toxicity and fibrosis and may progress to cirrhosis and liver failure. We show that CCN1 (also known as CYR61), a matricellular protein that dampens and resolves liver fibrosis, also mediates cholangiocyte proliferation and ductular reaction, which are repair responses to cholestatic injury. In cholangiocytes, CCN1 activated NF-κB through integrin αvβ5/αvβ3, leading to
Ki-Hyun Kim, Chih-Chiun Chen, Gianfranco Alpini, Lester F. Lau
Reversal of HIV-1 latency by small molecules is a potential cure strategy. This approach will likely require effective drug combinations to achieve high levels of latency reversal. Using resting CD4+ T cells (rCD4s) from infected individuals, we developed an experimental and theoretical framework to identify effective latency-reversing agent (LRA) combinations. Utilizing ex vivo assays for intracellular HIV-1 mRNA and virion production, we compared 2-drug combinations of leading candidate LRAs and identified multiple combinations that effectively reverse latency. We showed that protein kinase C agonists in combination with bromodomain inhibitor JQ1 or histone deacetylase inhibitors robustly induce HIV-1 transcription and virus production when directly compared with maximum reactivation by T cell activation. Using the Bliss independence model to quantitate combined drug effects, we demonstrated that these combinations synergize to induce HIV-1 transcription. This robust latency reversal occurred without release of proinflammatory cytokines by rCD4s. To extend the clinical utility of our findings, we applied a mathematical model that estimates in vivo changes in plasma HIV-1 RNA from ex vivo measurements of virus production. Our study reconciles diverse findings from previous studies, establishes a quantitative experimental approach to evaluate combinatorial LRA efficacy, and presents a model to predict in vivo responses to LRAs.
Gregory M. Laird ... Janet D. Siliciano, Robert F. Siliciano
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