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WASHINGTON (AP) — Friends and family will be able to take the first step to save a loved one from an overdose of heroin or powerful painkillers called opioids.
FDA approves easy-to-use heroin overdose antidote
The Food and Drug Administration on Thursday approved an easy-to-use device that automatically injects the right dose of an overdose antidote named naloxone before an ambulance arrives. Doctors could prescribe it for family members or caregivers to keep on hand, in a pocket or a medicine cabinet.
Opioids include legal prescription painkillers, such as OxyContin and Vicodin, as well as illegal street drugs like heroin.
Called Evzio, the device contains naloxone, a long-used antidote for overdoses that is usually administered by syringe in ambulances or emergency rooms. But with the rise in drug overdose deaths, there has been a growing push to equip more people with the protection.
The FDA said Evzio's design makes it easy for anyone to administer. Once Evzio is turned on, it provides verbal instructions, much like defibrillators that laymen frequently use to help people who collapse with cardiac arrest. It is about the size of a credit card or small cellphone.
The antidote is not a substitute for immediate medical care, the FDA said, as anyone who has overdosed will need additional treatment.
Still uncertain is how much the antidote will cost. Executives of the drug's manufacturer, kaléo, Inc., of Richmond, Va., said it is too soon to say, but they are working with health insurers to get broad coverage.
Eric Edwards of kaléo says the antidote is intended not just for heroin or prescription drug addicts, but also for people who have accidental overdoses, unexpected drug interactions or are on very high doses of the drugs. People who overdose may suffer slower breathing or heart rates or loss of consciousness.
FDA Commissioner Margaret Hamburg said in a statement that 16,000 people die every year due to opioid-related overdoses, and that drug overdose deaths are now the leading cause of injury death in the United States, surpassing motor vehicle crashes. She said the increase in overdose deaths has largely been driven by prescription drug overdoses.
"While the larger goal is to reduce the need for products like these by preventing opioid addiction and abuse, they are extremely important innovations that will help to save lives," Hamburg said.
Continue reading this story on the...


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Honduras: Inauguration of Trujillo as a Cruise Ship Port
With more than 200 tourists on board, a cruise ship docked in Trujillo Port, in the Honduran Caribbean, for the first time.
Thursday, March 5, 2009
Ricardo Martinez, Minister of Tourism, informed Laprensahn.com: "We are planning to exceed the 430 thousand cruise passengers that were received in the whole country last year and at least reach 450 thousand which means more than 160 arrivals by 15 companies. Cruise ships represent nearly 27% of the visitors entering the country."
Source: laprensahn.com
Roatan Loses $250 Thousand Daily Due to Protests
May 2009
Cruise ships are canceling their arrivals to the Honduran island because they are unable to operate due to local workers' protests that block the port.
Cruise Terminal in Bay of Trujillo
March 2012
Honduras is to develop the 'Banana Coast' cruise port in Trujillo and promote this project in the Cruise Shipping Miami 2012 event.
Honduras: Cruise Ships Return to Roatán
May 2009
Protests by the island's inhabitants, which culminated last Saturday, caused a nearly $1 million in losses from cruise cancellations.
Panama: Cruise Tourism Up 9%
January 2014
Up to November last year, 301,149 tourists arrived on cruise ships at Panamanian ports, 9.2 % more than in the same month in 2012.
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subset: commoncrawl


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First National Bank is committed to giving back to our communities through the charitable giving of financial support and volunteer hours. Each year, First National Bank employees log countless hours in support of various events and organizations. Like you, we live and work in this community and care about the welfare of both its resources and people.
To request a donation or sponsorship, please complete the Online Sponsorship Request Form.


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Secretary Dennis G. Statement on Government Accountability Office Report
MADISON-The United States Government Accountability Office (GAO) recently released a report, Medicaid Expansion: States' Implementation of the Patient Protection and Affordable Care Act. Wisconsin Department of Health Services Secretary Dennis G. Smith today offered the following statement:
"The GAO has confirmed the concerns we have expressed for some time-that the federal government has failed to release a credible plan for meeting the deadlines imposed, by law, to implement the Patient Protection and Affordable Care Act. States across the country are echoing these same concerns that guidance that is critical to successful implementation continues to be missing."
"When only six state budget directors view the guidance released by the Centers for Medicare and Medicaid Services (CMS) to help states implement the Medicaid provisions and 30 state budget directors respond that the guidance is merely "slightly useful" or "not useful at all," federal officials need to admit there are major problems. The expectation that states should continue to spend taxpayer dollars to implement a law without adequate or clear guidance is a prime example of government waste."
"Washington needs to face the reality of the situation and be honest with the American people that the deadlines provided in the law will not be met. The GAO report is a clear warning sign that should not be ignored."
The GAO report can be found here: http://www.gao.gov/products/GAO-12-821.


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Replace, repair or leave alone?
This is the door sill for the front of my 1919 house. The square nails lead me to to believe it's the original wood sill. If this were your house, would you replace it?
If replacing it is a bad idea from an old house point of view, then what? I could do a credible job of filling in the cracks and missing areas with wood filler, but doubt I could stain it well enough to pass for wood. I'm thinking of just leaving it as is, staining and topcoating with a sealer. I have adjusted the door so it isn't rubbing the wood.
(I scraped the paint off the threshhold at the top of the photo. The paint plan calls for that to be painted green to match the door frame, but if I can get all the paint off, I might stain and clearcoat it.)
Well, if you're asking what I would do...I would replace it.
However, you seem to like the idea of staining it and keeping a bit of the old house. I think that's a great idea and the square nails will be a real conversation piece. If it's still functional, why not? :)
When I bought my house some of my sills had been replaced with modern machine cut oak sills. My carpenter was doing some work and ended up milling new sills out of some beautiful maple for me. My house has oak floors, poplar trim, but original maple sills. I love the way he did it; I had to stain them to match the old carefully, but now you can't tell the difference between old and new. The modern sills were so out of place.
But, if I could patch that corner with wood putty reasonably well, I'd keep it. There are a lot of lousy putties out there; I've had reasonable luck on small jobs with JB weld Kwikwood, and on larger projects, ConServ products (but that's a lotta $$$ for such a small patch, and I don't think you need to pay the big bucks for the performance characteristics of the conserv for an indoor application.)
I like the look of a well-executed repair. I remember touring castles and mansions in Europe where things were carefully maintained or repaired instead of replaced; to me, it just contributed to the antique feel of the building, but in a cozy, not decrepit, way.
I don't see anything wrong with the sill but I'd paint it instead of trying to stain it. Chances are there will always be bits of old paint showing through any stain that you do.
The threshhold is a toss up but I'd probably keep it. My exterior ones were worn so thin my husband trashed them when he initially installed a temporary door for security but my interior ones looked very similar to yours prior to floor finishing. Now they're beautiful but still worn in keeping with the house.


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Intermediate Skis - MensProBoardshop has the best selection of Intermediate Skis for those who want to take skiing to the next level. With hundreds of Intermediate Skis from the most trusted brands, ProBoardshop has a pair for you no matter your budget. Our fast free shipping makes it easy to ditch the old sticks and move up a class!
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- Price: 200.00 - 299.9
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Size: 169, 179Reg: $360.00
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Size: 179Reg: $500.00
50% OffOn Sale: $249.95


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|Property type
|Minimum Stay
|30 nights
These luxurious and newly renovated apartments, apartment 1 without balcony and apartment 2 with balcony, are set in the historic Gothic quarter of Barcelona. They are situated in superb location set in the heart of an attractive neighbourhood of small streets, with many traditional bars and restaurants to relax in. The apartments are within easy walking distance of the beautiful palm fringed marina, the beach, the Ramblas, the old cathedral and many other popular sites. Small roof top terrace open April to Oct.
The comfortable and quiet apartments, with the benefit of elevator access, have been renovated and furnished to the highest standards in a contemporary style whilst still retaining the rustic charm of the old building. Double glazed windows and balcony doors help keep the street noise out ! The apartments comprise a spacious double bedroom with fitted wardrobe. Adjacent to the bedroom is a separate large bathroom with fully tiled and glass enclosed walk in shower. Relax on the sofa in the open plan living dining area with fully equipped fitted kitchen, breakfast table, flat screen TV and free fast WI FI.
The apartments have an interconnecting private lobby and can be connected to form one very large apartment for 4 to 6 people.
My husband I rented this place for four nights in October. An amazing location in the old historic area with quick access to everything. Apartment was surprisingly sleek and modern. Everything was new from the faucets to the windows to the kitchen and everything in between. Great food and bars all around within quick walking distance. This place even has a ( very small ) elevator!! Apartment is bright and modern. Lots of windows ( no views though.) Dealing with Jordi was a true pleasure and he met us promptly for check in. I would highly recommend this place to anyone and can not wait to return myself.
My husband and I rented this apartment for 5 nights prior to going on a 12 night cruise. We were extremely pleased with the condition of the apartment as well as the location. The apartment is exactly as it appears in the pictures and as described. It was very clean and Jordi, the apartment manager, was quite helpful in providing directions and options on travel to the apartment from the airport and was there to meet us, just as he had agreed to. Location is ideal - a short walk to Las Ramblas, Plaza Catalunya and the beautiful Barcelonetta Beach and in close proximity to the port for anyone taking a cruise out of Barcelona. Many supermarkets, bars, cafes, restaurants and shops all around the apartment We would definitely return and would certainly recommend this apartment for couples or those with one child.
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Monthly *
|Event Price
Low Season
1 Dec - 28 Feb
30 nights
High season
27 Jun - 30 Sep
30 nights
Mid Season
1 Oct - 30 Nov
30 nights
|No additional mandatory fees
Returnable damage deposit: €150
Late arrival after 21.00: €35
Payment by cash or card
Rates are for 2 adults and 1 child. Supplement for additional adults €15 per person. Maximum 4 adults.
* Approximate monthly price. Actual pricing will depend on the days of the month you stay.
Please Note: The owner of this property accepts payment in the original currency specified (EUR), before use of conversion tool. The conversion tool is provided for your convenience only. The owner may accept other currencies if specifically agreed in advance.


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|Half Baths
|Property type
|Minimum Stay
|2 nights
Thank you for visiting us. We are located approximately 8 miles north of Leakey in Rancho Real on the west fork of the Frio River just off of Ranch Road 336. The property is approximately 5.5 acres and resides on the Frio River (about 350 Yards from the house at the top of the property).
The Frio River gets its name for its cool and consistent flow and is a popular summertime destination for those wishing to enjoy the beauty of the Frio Canyon and Texas Hill Country. We will do our best to make your stay here as enjoyable as possible.
What an awesome get away, nice, quiet and secluded. The house is everything it says it is on the website, big, roomy, clean and every room has a bathroom. The area is beautiful, I've been to leakey many a time but not on this route were the scenery is even better. Mr. Davis is one of the nicest guys you'll ever meet and even a greater host. We enjoyed ourselves very much and thank Mr. Davis for the hospitality.
Wow -- another fabulous Girl's Weekend. This was our second visit. It is the perfect place for us to get together. The cabin is clean and comfortable - a true "home away from home." And, there was a delicious coconut cream pie in the fridge complements of Mark. Thanks Mark for the pie, the firewood, and special attention we received. We will return.
Linda D.
Mark Mark Mark!!??!! That's all you hear from the previous reviews, well, it's justified. Mark is a Great Guy and a Great Host. He made us feel like we were at home the moment we met him, we didn't feel like we wanted our money and couldn't wait for us to leave. His buddy Alan is pretty cool too. Ok, the house was nice, as posted by others, pictures don't do it justice. It was very clean. We did a guys weekend out for some awesome motorcycle riding and I plan on bringing the wife and kidos one summer to enjoy the nearby water holes. You wont regret it.
This is a awesome place to come an relax and just get away. Mark is a awesome host he showed us some great swimming holes and yes there is plenty of water. This is a great home away from home, and the ice cream just made my kids day. We are ready to book again next year!!!!!
We loved staying here. The house was very nice and very relaxing. We had a great stay and will be back soon.
Sorry I haven't done this sooner, but better late than never. We stayed here for a week in June 2012. We had a large group, ages 4 thru 64. We all had a great time. The photos don't do the house justice. It's set up perfect and the beds are very good. Mark, our host was wonderful. He was very attentive and helpful. My biggest complaint was, the fridge was too stocked with food. LOL. There was already plenty of catsup, mustard, flour, sugar, salt, pepper, even coffee and etc... and we brought more. I was a little concerned about the distance to the water when we first arrived, but soon realized it was OK. It's not right on the water but you do have private access with plenty of room. We almost had this part of the river to ourselves. Lots of trails for the kids to explore and the view is wonderful. No need to stock up on groceries and adult beverages before you get to Leakey. they have a nice little merchantile grocery and the prices are just as good as in Uvalde. WE all had a great time and will go back. I have recommended Marks place to many of my friends and YES we did get our pies and ice cream. yummmy
From the junction of Hwy 83 and 336 go 8 miles to Old Rock Springs road. The road is about 1/4 mile from Kent creek crossing. Right on Old Rock springs road about .7 miles look for the numbers 898 on a post on the right hand side of the road. Right on the road stay right past the first house to the cabin.
|Rate Period
|Weekend Night
Peak Season
May 26 2015 - Sep 7 2015
2 night minimum stay
My Standard Rate
2 night minimum stay
|Cleaning Fee
|$50 + Tax
|Tax Rate
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.
Learn more about this vacation rental at the owner's website:


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According to the report by The Guardian, a national sperm bank will be launched in UK to meet the increasing demand for sperm. The National Gamete Donation Trust (NGDT), in partnership with Birmingham Women's Hospital, has been awarded £77,000 by the Department of Health (DoH) to provide the service, which will launch in October.
Given too much myths associated with sperm, this is probably high time to get facts right about something as important as this body fluid.
According to the report by Fox News, urologist Dr Harry Fisch, clinical professor of reproductive medicine at Weill Medical College of Cornell University, said, the first moment of ejaculation contains the highest concentration of sperm.
2.The Duration:
Sperm usually stays in a woman's body for 48 hours after sex, but depending on a woman's cervical mucus, sperm can be present for up to five days to as long as a week. Cervical mucus provides protection to sperm and also helps it to stay longer in the body around the period of ovulation, when a woman is most fertile.
3.More Sex or Masturbation Doesn't lower a Man's Sperm Count
Dr Carrie Wambach from Southern California Reproductive Center in Los Angeles confirmed to Fox News that having more sex or masturbation doesn't lower a man's sperm count. Too much of ejaculation may affect the volume, but in men with normal sperm count, that should not be a problem.
4.Temperature Can Lower Sperm Count
Sperm count is usually lowest during summer and highest in winter, said Fisch. Overheating reduces sperm count.
5.The Pineapple Connection
Semen contains a natural sugar called fructose, thus giving it a little sweet taste, but to date, there has been no study to confirm if there is any association between the food a man eats and the taste of his sperm.
6.Male and Female Sperm are Completely Equal
Sperm has either the X or Y chromosome, but their chances of making it don't differ, claimed Fisch. But the concept that one type is more resilient than the other is not true.
7.It's Too Rare an Event to Be Allergic to Sperm
Even though there have been lot of discussions on sperm causing inflammation or redness, according to experts, being allergic to sperm is an extremely rare event.
8.Individual Health Affects Health of Sperm
Sperms are healthier in men who are non-smokers; avoid high fat diet and environmental toxins.
9.The Journey of a Sperm
It takes about two and a half months to prepare all the sperm expelled in the average ejaculation. It initially forms in the testicles then moves up to the epididymis. Then fully formed sperm travels through the vas deferens and swings by the seminal vesicles where it mixes with a fluid to form semen. Finally, the prostate adds the last little bit of fluid before ejaculation, doctors said."


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The Answer May Surprise You — and Surprise Critics of Capitalism Even More!
You, your family and friends may well share in McDonald's profits, if you belong to what we loosely call the middle class, those of us who are neither really rich nor really poor.
You may not have known you're an owner — few people do — but, it's true nevertheless. Through pension funds, mutual funds, and other savings vehicles you and I became accidental capitalists, as we saved for retirement and other important goals.
If you put money into a pension or mutual fund, you own tiny slivers of a number of big corporations–like McDonald's. Individually, none of us owns as much as a millionaire or billionaire, but when you consider how many of us in the middle class contribute to funds, suddenly we're big-time capitalists.
For example, did you know 96.2 million Americans owned mutual funds in 2013? $15-trillion worth of funds? (2014 Investment Company Fact Book)
Did you know that the California Public Employees' Retirement System (CALPERS), one of the world's largest pension funds, and made up state employees at all levels, from janitors to judges, controls about $300 billion worth of assets? And that's just one of the many thousands of pension funds worldwide.
Through our ownership via mutual funds and pension funds, we collectively receive literally billions of dollars every year in profits and dividends. So you and I share in the profits of every Big Mac and fries, as well as the products and services sold by almost every big corporation.
How we and hundreds of millions of other middle class people became owners of companies like McDonald's is one of the most fascinating — and unknown — stories of the past 70 years.
Learn more about this story in the mini book, Big Macs & Our Pensions: Who Gets McDonald's Profits? It's easy to read, easy to understand, and complete in three chapters.
The Kindle ebook version of Big Macs & Our Pensions: Who Gets McDonald's Profits? sells for just 99 cents or less.
to learn more and to read a sample; you can also download the free Kindle reader for your PC or Mac, if needed.
PS: You'll also find out how much of the cost of your lunch at a McDonald's is a profit for the company!


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Fit in S.A.
Jessica Belasco on the latest on local fitness news, upcoming races, gym openings and how San Antonio residents are getting in shape.
Get ready to get dirty
Register now for upcoming mud runs across Texas. [Read More]
Review – 'Dancing with the Stars: Cardio Dance for Weight Loss'
This cardio dance workout with "Dancing with the Stars" pros Mark Ballas and Kym Johnson lives up to its name – you will, indeed, dance your butt off – but not the "perfect for beginners" sticker on the cover. The lessons aren't complicated, but the pace is too fast for a beginner to feel comfortable […] [Read More]
Síclovía a step forward for San Antonio
The city's second fitness event attracted 40,000 walkers, runners, cyclists, skaters and more. [Read More]
New half-marathon: Alamo 13. 1 Fight to the Finish
The Alamo 13.1 Fight to the Finish, which benefits the Leukemia & Lymphoma Society's Team in Training, will be on March 18. A two-person relay option is also available. [Read More]
Curves offer: donate food, join for free
Participate in the annual Curves food drive by donating food or money to the food bank, and the club will waive the joining fee. [Read More]
Walking 20 miles is doable with training
Walk to Action, a 20-mile non-competitive walk to raise money and awareness of the prevention of child abuse, is coming up Nov. 3. Here's how to train for it. [Read More]
Get ready for the Senior Games
The Senior Games begin March 22. There's still time to register and train. [Read More]
The fitness DVD industry is, well, fit
Thanks to reality TV and the economy, fitness DVDs remain popular. [Read More]


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I picked up a mixed 6'er at the beer store Sat. night. All was going well until I opened up the Magic Hat #9. It was skunked past being drinkable. I noticed that their bottle was a bit lighter than most of the rest of the bottles that I have saved. The beer store was much too bright, but none of the other beers I picked up showed any sign of being skunked. Has anyone else had any trouble with other Magic Hat beers?
Every Magic Hat #9 I've ever had has tasted like that. I thought they skunked it at the brewery.
The ones I have tried in a bottle (only twice) were that bad too. However, I had it on draft for lunch today and it was much better. It was the beer of the month special but I didn't want to order one without a taste first. Much better than in a bottle. Still overrated, but I would get it again on special.
Check the age on the bottle.
I've never had any Magic Hat that was stale, but then again, I live about 3 miles from the brewery.
I think it was dated for march 2009 or somewhere around there. It wasn't stale, it was skunked.


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Pool Charlotte/waxhaw NC
I want to share my pool experience with future pool buyers. Let me start by saying I am retired enforcement from New York. In late January 2012 I started shopping pools. We had several companies come over give us idea's and of course the price! The process went some what smooth. We had Blue Haven, Anthony & S, pool king, and superior. What surprised me was (2) of them knocked the other companies pretty bad. It was a turn off. They should have pushed on there merits. We ended up going with Superior Pools. We liked the salesman and we asked to meet the owner. He came back over for the third time with the owner. After I explained to him (Peter) my concerns over what the other companies were saying he answered everything. Over the next (2) weeks I talked to prior customers and liked everything I heard. One company even kept calling after we told him we signed the contract. Sorry "Brian" the bad mouthing was a turnoff ! After getting homeowner's assocition approval. We moved forward with the project. Superior started beginning of march. In (5) weeks my pool was complete. Being the way I am I called a lot. I always have questions. They always took my calls and when I asked for Peter he took it or always returned my calls promptly. We are very happy with our beautiful pool. I would recommend Superior Pools anytime. Here's to Peter and his entire staff. Thanks for a great job !!!!!!!!!
We too went with Superior Pools and we are on week 5 and tile and coping are next... So far, what a great job! We got the same quotes and had the same experience. Peter at Superior came highly recommended by a neighbor who said "this guy builds a good pool". As I read these post, I am honestly surprised by the number of bad experiences...like most I have been a "nervous nellie" and have called Peter and our project manager almost 2-3 times a week... I ALWAYS get a returned phone call and ALWAYS feel better after talking. I have really used this forum to compare my progress and I have to say that so far, so good... not a crack in the gunite and everything has been done really well!! I would post some pictures, but need someone to show me how!!! LOL!!!
I will keep this forum posted on the progress!!!


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Janet E Hall (born 1945)
Biography & Family History Add details
Janet E Hall (born 1945) was born on October 13, 1945. She was born into the Hall family.
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Immunocytochemical study of parvalbumin, calbindin D-28k, and calretinin in the superficial dorsal horn of the rat spinal cord following unilateral hindpaw inflammation
- Yoko Mineta,
- Hiroshi Koyanagi,
- Masatoshi Morimoto,
- Kiyoshi Harano,
- Tadahide Totoki,
- David M. Jacobowitz
- … show all 6 hide
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The effect of noxious stimulation on the immunore-activity of the calcium-binding proteins parvalbumin (PV), calbindin-D-28k (CB) and calretinin (CR) was investigated in the superficial dorsal horn of lumbar levels L5-L3 of the rat spinal cord. Freund's adjuvant was injected unilaterally into the hindpaw to induce inflammation. Immunohistochemical techniques were utilized to investigate changes in the calcium-binding proteins 2h and 1, 2, 4, and 7 days after injection. At 24h after injection, a decrease in the intensity of fluorescence of PV-immunoreactive (IR) fibers was observed in the superficial layer (substantia gelatinosa) of the ipsilateral dorsal horn (L5-L3) in most animals. Comparatively fewer animals exhibited changes in the CB- and CR-IR fibers, except at the L3 level 2 days after, and at the L4 level 7 days after the hindpaw injection. After the peak response, at 24h in most animals, there was a decline in the number of responders at 2 days and no differences were noted at 4 days. However, at 7 days, there was again an increase in the number of animals revealing diminished fluorescence intensity in the ipsilateral substantia gelatinosa. Changes in immunoreactivity of calcium binding proteins in the interneurons of the superficial lumbar dorsal horn may reflect hyperactivity within these neurons following noxious stimulation.
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- Neher, E (1992) Controls on calcium influx. Nature 355: pp. 298-299 CrossRef
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- Antal, M, Freund, TF, Polgár, E (1990) Calcium-binding proteins, parvalbumin and calbindin-D28k immunoreactive neurons in the rat spinal cord and dorsal root ganglia: A light and electron microscopic study. J Comp Neurol 295: pp. 467-484 CrossRef
- Fournet, N, Garcia-Segura, LM, Norman, AW, Orci, L (1986) Selective localization of calcium-binding protein in human brainstem, cerebellum and spinal cord. Brain Res 399: pp. 310-316 CrossRef
- Ren, K, Ruda, MA (1995) A comparative study of the calcium binding proteins calbindin-D28k, calretinin, calmodulin and parvalbumin in the rat spinal cord. Brain Res Rev 19: pp. 163-179 CrossRef
- Ren, K, Ruda, MA, Jacobowitz, DM (1993) Immunohistochemical localization of calretinin in the dorsal root ganglion and spinal cord of the rat. Brain Res Bull 31: pp. 13-22 CrossRef
- Yamamoto, T, Carr, PA, Baimbridge, KG, Nagy, JI (1989) Parvalbumin and calbindin-D28k immunoreactive neurons in the superficial layers of the spinal cord dorsal horn of the rat. Brain Res Bull 23: pp. 493-508 CrossRef
- Yoshida, S, Senba, E, Kubota, Y, Hagihira, S, Yoshiya, I, Emson, PC, Tohyama, M (1990) Calcium-binding proteins calbindin and parvalbumin in the superficial dorsal horn of the rat spinal cord. Neuroscience 37: pp. 839-848 CrossRef
- Grant, G (1993) Projection patterns of primary sensory neurons studies by transganglionic methods: Somatotopy and targetrelated organization. Brain Res Bull 30: pp. 199-208 CrossRef
- Molander, C, Grant, G (1985) Cutaneous projections from the rat hindlimb foot to the substantia gelatinosa of the spinal cord studied by transganglionic transport of WGA-HRP conjugate. J Comp Neurol 237: pp. 476-484 CrossRef
- Zimmerman, M (1983) Ethical guidelines for investigation of experimental pain in conscious animals. Pain 16: pp. 109-110 CrossRef
- Molander, C, Xu, Q, Grant, G (1984) The cytoarchitectonic organization of the spinal cord in the rat. The lower thoracic and lumbosacral cord. J Comp Neurol 230: pp. 133-141 CrossRef
- Paxinos, G, Watson, C (1986) The rat brain in stereotaxic coordinates. Academic, New York
- Winsky, L, Nakata, H, Martin, BM, Jacobowitz, DM (1989) Isolation, partial amino acid sequence and immunohistochemical localization of a brain-specific calcium-binding protein. Proc Natl Acad Sci USA 86: pp. 139-10143 CrossRef
- Fitzgerald, M, Sweet, JE (1983) The termination pattern of sciatic afferents in the substantia gelatinosa of neonatal rats. Neurosci Lett 43: pp. 149-154 CrossRef
- Robertson, B, Grant, G (1985) A comparison between wheat germ agglutinin and choleragenoid-horseradish peroxidase as anterograde transport markers in central branches of primary sensory neurons in the rat with some observations in the cat. Neuroscience 14: pp. 895-905 CrossRef
- Smith, CL (1983) The development and postnatal organization of primary afferent projections to the thoracic spinal cord. J Comp Neurol 220: pp. 29-43 CrossRef
- Molander, C, Grant, G (1986) Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat. Neuroscience 19: pp. 297-312 CrossRef
- Rivero-Melian, C, Grant, G (1991) Choleragenoid horseradish peroxidase used for studying projections of some hindlimb cutaneous nerves and plantar foot afferent to the dorsal horn and Clark's column in the rat. Exp Brain Res 84: pp. 125-132
- Swett, JE, Woolf, CJ (1985) The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord. J Comp Neurol 231: pp. 66-77 CrossRef
- Ueyama, T, Arakawa, H, Mizuno, N (1987) Central distribution of efferent and afferent components of the pudendal nerve in the rat. Anat Embryo 177: pp. 37-49 CrossRef
- Woolf, CJ, Fitzgerald, M (1986) Somatotopic organization of cutaneous afferent terminals dorsal horn neuronal receptive fields in the superficial and deep laminae of the rat lumbar spinal cord. J Comp Neurol 251: pp. 517-531 CrossRef
- Ygge, J, Grant, G (1983) The organization of the thoracic spinal nerve projection in the rat dorsal horn demonstrated with transganglion transport of horseradish peroxidase. J Comp Neurol 216: pp. 1-9 CrossRef
- Presley, RW, Menétrey, D, Levine, JD, Basbaum, AI (1990) Systemic morphine suppresses noxious stimulus-evoked fos protein-like immunoreactivity in the rat spinal cord. J Neurosci 10: pp. 323-335
- Draisci, G, Iadarola, MJ (1989) Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord. Mol Brain Res 6: pp. 31-37 CrossRef
- Iadarola, MJ, Brady, LS, Draisci, G, Dubner, R (1988) Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity behavioral parameters and opioid receptor binding. Pain 35: pp. 13-326 CrossRef
- Iadarola, MJ, Douglass, J, Civelli, O, Naranjo, JR (1988) Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: Evidence using cDNA hybridization. Brain Res 455: pp. 205-212 CrossRef
- Millan, MJ, Millan, MH, Czlonkowski, A, Höllt, V, Picher, CWT, Hertz, A, Colpaert, FC (1986) A model of chronic pain in the rat: Response of opioid systems to adjuvant-induced arthritis. J Neurosci 6: pp. 899-906
- Chavkin, C, Goldstein, A (1981) Dynorphin is a specific endogenous ligand of the k-opioid receptor. Science 215: pp. 413-415
- Law, PY, Hom, DS, Loh, HH (1982) Loss of opiate receptor activity in neuroblastoma X glioma NG 108-15 hybrid cells after chronic opiate treatment. Mol Pharmacol 22: pp. 1-4
- Strang, PF, Potter, JD (1992) A monoclonal antibody that recognizes different conformational status of skeletal muscle troponin C and other calcium binding proteins. J Muscle Res Cell Motil 13: pp. 308-314 CrossRef
- Winsky L, Kuznick J (1994) Evidence for calcium-dependent antibody recognition of calcium binding proteins. Soc Neurosci Abstract: 20
- Johansen, FF, Tønder, N, Zimmer, J, Baimbridge, KG, Diemer, NH (1990) Short-term changes of parvalbumin and calbindin immunoreactivity in the rat hippocampus following cerebral ischemia. Neurosci Lett 120: pp. 171-174 CrossRef
- Nitsch, C, Scotti, A, Sommacal, A, Kalt, G (1989) GABAergic hippocampal neurons resistant to ischemia-induced neuronal death contain the Ca2+-binding protein parvalbumin. Neurosci Lett 105: pp. 263-268 CrossRef
- Rami, A, Rabie, A, Thomasset, M, Krieglstein, J (1992) Calbindin-D28k and ischemic damage of pyramidal cells in rat hippocampus. J Neurosci Res 31: pp. 89-95 CrossRef
- Freund, TF, Maglóczky, ZS (1993) Early degeneration of calretinin-containing neurons in the rat hippocampus after ischemia. Neurosci 56: pp. 581-596 CrossRef
- Sloviter, RS (1989) Calcium-binding protein (calbindin-D28k) and parvalbumin immunocytochemistry: Localization in the hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity. J Comp Neurol 280: pp. 183-196 CrossRef
- Freund, TF, Ylinen, A, Miettinen, R, Pitkänen, A, Lahtinen, H, Baimbridge, KG, Riekkinen, PJ (1991) Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability. Brain Res Bull 28: pp. 27-38 CrossRef
- Title
- Immunocytochemical study of parvalbumin, calbindin D-28k, and calretinin in the superficial dorsal horn of the rat spinal cord following unilateral hindpaw inflammation
- Journal
Journal of Anesthesia
Volume 10, Issue 3 , pp 211-217
- Cover Date
- 1996-09-01
- Print ISSN
- 0913-8668
- Online ISSN
- 1438-8359
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
- Parvalbumin
- Calbindin D-28k
- Calretinin
- Spinal cord
- Immunohistochemistry
- Industry Sectors
- Authors
- Yoko Mineta (1)
- Hiroshi Koyanagi (1)
- Masatoshi Morimoto (2)
- Kiyoshi Harano (1)
- Tadahide Totoki (1)
- David M. Jacobowitz (3)
- Author Affiliations
- 1. Department of Anesthesiology, Saga Medical School, 5-1-1 Nabeshima, 849, Saga, Japan
- 2. Laboratory Animal Center, Saga Medical School, 5-1-1 Nabeshima, 849, Saga, Japan
- 3. Laboratory of Clinical Science, National Institute of Mental Health, Building 10, Room 3D-48, 10 Center Drive-MSC 1266, 20892-1266, Bethesda, MD, USA


text: A little class, a little sass, but never trash. Enjoying San Francisco and all it has to offer. Having worked as a Director of Sales for the Marriott Brand Hotels I keep my home at "Hotel Quality" and value customer service. Staying with me is like staying at a small room Boutique Hotel.


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Google, Microsoft, and other companies will work closely with the Internet Advertising Bureau (IAB) to provide education and solve issues regarding programmatic trading.
Google, Microsoft, and other companies have joined the Internet Advertising Bureau (IAB)'s first working group in order to tap into the intricacy of programmatic trading across mobile devices.
As the data-driven, targeted, and cost-effective ad inventory begins to appeal to more and more advertisers, programmatic ad buying and selling have seen a robust growth in developed Internet markets like the U.S.
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Global Furniture USA Jolie Parsons Chair
Global Furniture USA Jolie Parsons Chair
Weights & Dimensions
|Product Type: Side chair
|Finish: Silver
|Distressed: No
|Frame Material: Metal; Plastic
|Number of Items Included: 4
|Arms Included: No
|Upholstered Seat: Yes
|Upholstered Back: Yes
|Style: Modern
|Back Style: Solid back
|Swivel: No
|Foldable: No
|Dining Type: Formal
|Number of Legs: 2
|Leg Material: Metal
|Felt Foot Pads: No
|Weight Capacity: 250 Pounds
|Commercial Use: No
|Product Care: Clean with damp cloth
|Country of Manufacture: Imported
|Assembly Required: Yes
|Additional Parts Required: No
|Product Warranty: 1 year limited
Questions & Answers (3)
"Hi, what is the fabric of this chair?" asked by Leslie
"Hi, can this chair only be purchased in a set of 2?" asked by Xiu
"Hi, what is the weight limit of the chair?" asked by Indira
Still have questions about this product? We're here to help
Global Furniture USA Jolie Parsons Chair
About the ManufacturerIn addition to becoming one of the premier importers and distributors of fine home furnishings in the United States, Global Furniture USA has become a prominent force in the international market as well. They offer single item shipments out of their east coast facility located in East Brunswick, New Jersey. They also provide a container program of cataloged items or custom made products based on customer specifications.
Their marketing and merchandising efforts are geared toward providing a broad selection of styles, at competitive prices, quick delivery to the consumer and strong customer support. They serve as a direct factory importer and as a result have been able to market their products at lower prices and offer quicker delivery than many of their competitors.
This flexibility, as well as industry best turn around times has allowed them to establish positive relationships with its customers while providing quality products at competitive prices.
Global Furniture USA is well known for their great products and they are constantly updating their product line. You and your family are sure to find the perfect piece for your home with Global Furniture USA.
NOTE: This product is subject to a minimum order quantity of 2
|5 star
|4 star
|3 star
|2 star
|1 star
good stylish chair, but...
Justin from Calgary, AB– Verified Buyer
The chair is a little bit bouncy. It bobs maybe about an inch. But it's sturdy and I don't feel like the chair is about to snap.
loved the chairs BUT....
Sharon from Kapolei, HI– Verified Buyer
I really loved the chairs I ordered because it matched my dining room table. The problems I had with it was when I took it out of the box, the upholstery was dirty. I think it was sitting so long in the warehouse that the holes where the screw is supposed to go on rusted and all the particles were all over the fabric. Luckily it was easy to clean with Mr. Clean Magic Eraser. Also, there were tiny punctures on the chairs on 2 out of the 6 chairs from the packaging. I would have returned the chairs but shipping them back would cost me a lot of money.
Comfy Chair
Russell from Colgate, WI– Verified Buyer
These chairs a decent quality for the price and comfy to sit on. The cushion could have better quality foam but good for the cost. Only negative is the chairs are very heavy and hard to slide on carpet.
Chair is really cool, but heavy!
Rebecca from Cortland, OH– Verified Buyer
The quality of these chairs is there, however, they are very heavy and difficult to push under the table and bring out from under the table. They should have some sort of material on the bottom to make them easy to push in and pull out. Other than that little defect, these chairs are really cool! Hopefully they will hold up for a long time!
Jolie Parson Chairs
Curtis from Kent, WA– Verified Buyer
Really nice chairs, you guys need to get the chairs in RED. They have them in Houston but they will not ship them outside the local area.
Good Chair, Seat Kinda Hard
Gina from Georgetown, TX– Verified Buyer
This is a good chair overall. My only compliant is that there is not much padding on the seat.
Great chair great price
Kendra from Eden Prairie, MN– Verified Buyer
This chair looks great.. A little uncomfortable hard foam, but overall worth the price!
Davida from St. Louis, MO– Verified Buyer
I really really loved this item at first sight, I second guessed thinking six hundred U.S. currency is a little steep for just some chairs. Then I critiqued them in every way possible looking for reasons to convince myself not to buy them, bcse a woman of my character and style believes there's no price u can put on something that u absolutely want and guaranteed not to see very often. I gave in sooner than I thought and has been very delightful ever since I did. Their everything;~} and does so much more than compliment my elegance.
Love these chairs
Cathy from St. Louis, MO– Verified Buyer
These chairs are a great conversation piece and a real contemporary design statement. An added bonus is that they are very comfortable. Terrific purchase!
Anton from Corte madera, CA– Verified Buyer
This product is very nice an I recommend it a lot.
OUR SKU # GQ2534Jolie Parsons Chair is also sometimes listed under the following manufacturer numbers: 88DC-BEI, 88DC-BL


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Immunology IMMUNOLOGY Sherko A Omer MB ChB, MSc., PhD 1 Immunology MOLECULES THAT RECOGNIZE ANTIGEN Recognition of foreign antigen is the character of adaptive immune response. Two different molecules can recognize antigens: Immunoglobulins (Ig) T cell receptors (TCR) 2 Immunology IMMUNOGLOBULIN Antibodies (Immunoglobulin) are glycoproteins with antibody activity. They combine specifically with the substances that may elicit them (immunogen or antigen). Immunoglobulin form the humoral arm of immune response. Immunoglobulin constitute 20% of total plasma proteins and are produced by plasma cells. 3 Immunology IMMUNOGLOBULIN Immunoglobulins consist from 82-96% polypeptide and 4-18% carbohydrate (glycoproteins). Immunoglobulins are bifunctional molecules that can bind specifically with an antigen and initiate a variety of secondary functions like complement fixation and attachment to other cells, and these secondary functions are independent of their specificity for antigens. 4 Immunology IMMUNOGLOBULIN 5 Immunology IMMUNOGLOBULIN Basic unit (monomer), each Immunoglobulin molecule contains at least one basic unit and this basic unit consists from four polypeptide chains. Heavy chain, each basic unit contains two identical heavy polypeptide chains each with approximately 400* amino acids. Light chain, each basic unit contains two identical light polypeptide chains each with approximately 200 amino acids. 6 Immunology IMMUNOGLOBULIN Each polypeptide chain of immunoglobulin have an amino terminal region (V) variable and a carboxyl terminal region (C) constant region, these terms describe the considerable variability in amino acid sequence in these regions. The polypeptide amino acids of are linked non adjacently to form globular regions called domains, heavy chain domains includes VH, CH1,CH2 and CH3 while the domains of light chain are VL and CL. An additional domain CH4 is seen in IgM and IgE. 7 Immunology IMMUNOGLOBULIN Paratope (antigen binding) consist from small numbers of amino acids in the V region of both heavy and light chains. Hinge region, an area in the heavy chain between CH1- CH2, this area is more exposed to enzymes and it is more flexible for movement of Fab arms, IgM and IgE have no hinge regions. 8 Immunology IMMUNOGLOBULIN Fab and Fc, digestion of IgG by the enzyme papain produce 2 Fab (Fragment antigen binding) and one Fc (Fragment crystallisable). F(ab`)2, digestion of IgG by the enzyme pepsin produce one F(ab`)2 which consist from 2 Fab and hinge region and 1 P Fc` that consist of a small peptide (small fragment). 9 Immunology IMMUNOGLOBULIN 10 Immunology IMMUNOGLOBULIN Disulfide bond, chemical disulfide bonds (S-S) are formed between cysteine residues, the bonds are essential for normal three dimensional structure of the immunoglobulin, disulfide bonds may be inter-chain (between H and H, H and L, or L and L chains) or intra- chains 11 Immunology IMMUNOGLOBULIN Five classes of Immunoglobulins are present according to the structure and antigenic characteristic of the constant C region of the heavy chain: IgG (G for Gamma ) IgA (A for Alpha ) IgM (M for Muta ) IgD (D for Delta ) IgE (E for Epsilon ) IgG have four subclasses (IgG1, IgG2, IgG3 and IgG4) IgA have two subclasses (IgA1 and IgA2). 12 Immunology IMMUNOGLOBULIN 13 Immunology IMMUNOGLOBULIN Light chains are divided into two types on the basis of antigenic structures, these are Kappa () and Lambda (), subtypes are present for lambda chain. S value, a value for sedimentation coefficient of immunoglobulin according to Svedberg's technique, the bigger molecular weight of that immunoglobulin the bigger the S value. Ig polymer, some Immunoglobulin consists from more than one basic unit such as like dimeric IgA and pentameric IgM. 14 Immunology IMMUNOGLOBULIN 15 Immunology IMMUNOGLOBULIN J chain, a polypeptide chain present in polymeric Immunoglobulins such as pentameric IgM and dimeric IgA . Secretary component (SC), a small polypeptide present in secretory IgA. 16 Immunology IMMUNOGLOBULIN Immunoglobulin isotype, antigenic differences that characterize the class and subclasses of heavy chain and type and subtypes of light chain. 17 Immunology IMMUNOGLOBULIN Immunoglobulin allotype, genetically determined antigenic differences in Immunoglobulins that varies in different members of the same species, these differences are located in C region so that a particular isotype may have several alternative allelic structure. 18 Immunology IMMUNOGLOBULIN Immunoglobulin idiotype, the antigenic determinant that distinguish variable region of Immunoglobulin from other variable region of other immunoglobulins. 19 Immunology IMMUNOGLOBULIN 20 Immunology IMMUNOGLOBULIN Glycosylation, carbohydrates are present in different amounts as simple or complex side chains of the C region of heavy chain, J or SC chain. Carbohydrates play role in secretion of Immunoglobulins by plasma cells. Complementarity-determining regions (CDRs), most of the differences among antibodies fall within areas of the V regions called CDRs on both light and heavy chains, that constitute the antigen binding site of the antibody molecule. 21 Immunology IgG Major immunoglobulin in human serum accounting for 80% of total serum Immunoglobulins There are 4 subclasses IgG (IgG1, IgG2, IgG3 and IgG4) each with either two or two light chains. IgG (IgG1, IgG3 and IgG4) are only Immunoglobulins that pass placenta so play an important role in protecting the developing fetus. 22 Immunology IgG IgG except IgG4 can fix complement through the classic pathway (lgG3 more than IgG1 and IgG2) using their CH2. IgG1 and IgG3 bind with high affinity to Fc receptors on phagocytic cells and thus mediate opsonisation. IgG4 has an intermediate affinity for Fc receptors, and IgG2 has an extremely low affinity 23 Immunology IgM IgM accounts for 5% –10% of the total serum immunoglobulin, with an average serum concentration of 1.5 mg/ml. Monomeric IgM, with a molecular weight of 180 000 Da, is expressed as membrane-bound antibody on B cells (mIg). IgM is secreted by plasma cells as a pentamer in which five monomer units are held together by disulfide bonds. 24 Immunology IgM IgM is the first immunoglobulin class produced in a primary response to an antigen. It is the first immunoglobulin to be synthesized by the neonate, its presence fetal blood indicates intra-uterine infection. Due to its pentameric structure, serum IgM has a higher valency than the other isotypes in binding antigens with many repeating epitopes such as viral particles. IgM is also more efficient than IgG at activating complement 25 Immunology IgM Because of its large size, IgM does not diffuse well and therefore is found in very low concentrations in the intercellular tissue fluids. The presence of the J chain allows IgM to bind to receptors on secretory cells, which transport it across epithelial linings to enter the external secretions that bathe the mucosal surfaces. IgM plays an important accessory role as a secretory immunoglobulin. 26 Immunology IgA Constitutes only 10%–15% of the total immunoglobulin in serum. Predominant immunoglobulin class in external secretions such as breast milk, saliva, tears, and mucus of the bronchial, genitourinary, and digestive tracts. In serum, IgA exists primarily as a monomer, but polymeric forms (dimers, trimers, and some tetramers) are sometimes seen, all containing a J chain. 27 Immunology IgA Binding of secretory IgA to bacterial and viral surface antigens prevents attachment of the pathogens to the mucosal cells, thus inhibiting viral infection and bacterial colonization. Complexes of secretory IgA and antigen are easily entrapped in mucus and then eliminated by the ciliated epithelial cells of the respiratory tract or by peristalsis of the gut. 28 Immunology IgA Secretory IgA has been shown to provide an important line of defense against bacteria such as Salmonella, Vibrio cholerae, and Neisseria gonorrhoeae and viruses such as polio, influenza, and reovirus. Breast milk contains secretory IgA and many other molecules that help protect the newborn against infection during the first month of life. Because the immune system of infants is not fully functional, breast-feeding plays an important role in maintaining the health of newborns. 29 Immunology IgE The potent biological activity of IgE allowed it to be identified in serum despite its extremely low average serum concentration (0.3g/ml). IgE antibodies mediate the immediate hypersensitivity reactions that are responsible for the symptoms of hay fever, asthma, hives, and anaphylactic shock. Localized mast-cell degranulation induced by IgE also may release mediators that facilitate a build up of various cells necessary for anti-parasitic defense. 30 Immunology IgD IgD, has a serum concentration of 30g/ml and constitutes about 0.2% of the total immunoglobulin in serum. IgD, together with IgM, is the major membrane-bound immunoglobulin expressed by mature B cells, and its role in the physiology of B cells is under investigation. No biological effector function has been identified for IgD 31 Immunology GENETICS OF IMMUNOGLOBULINS The genes for Immunoglobulin molecules are located on different chromosomes. Heavy chain genes are on chromosome 14. light chain gens are on chromosome 22. light chain are located on chromosome 2. 32 Immunology GENETICS OF IMMUNOGLOBULINS The enormous numbers of Immunoglobulins are formed by somatic recombination of different genes. For heavy chain there are different variable (V), diversity (D), joining (J) and constant (C) genes. For light chain there are different V, J and C genes. Different recombination of these genes gives different Immunoglobulins. 33 Immunology GENETICS OF IMMUNOGLOBULINS 34 Immunology MONOCLONAL ANTIBODIES 35 Immunology MONOCLONAL ANTIBODIES Uses: Measurement of proteins and drugs in the serum. Tissue and blood typing. Identification of infectious agents. Identification of CD that can be used for classification and follow-up of leukaemia and lymphoma. Identification of tumour antigens. Identification of autoantibodies in a variety of diseases. 36 Immunology B CELL RECEPTOR (BCR) The mIg have very short cytoplasmic tails which are too short to be able to associate with intracellular signalling molecules. (BCR) is a transmembrane protein complex composed of mIg and disulfide- linked heterodimers called Ig-/Ig-. 37 Immunology B CELL RECEPTOR (BCR) Molecules of this heterodimer associate with an mIg molecule to form a BCR. The Ig- chain has a long cytoplasmic tail containing 61 amino acids; the tail of the Ig- chain contains 48 amino acids. The tails in both Ig-/Ig- are long enough to interact with intracellular signalling molecules. 38 Immunology BCR Some of the many signal-transduction pathways activated by the BCR 39 Immunology T CELL RECEPTORS (TCR) Cells that express TCRs have approximately 105 TCR molecules on their surface. TCR are exist as either and -T cell receptors. Each chain in a TCR has two domains containing an intrachain disulfide bond that spans 60–75 amino acids. The amino-terminal domain in both chains exhibits marked sequence variation, but the sequences of the remainder of each chain are conserved. 40 Immunology T CELL RECEPTORS (TCR) TCR domains include one variable (V) and one constant (C) that are structurally homologous to the V and C domains of immunoglobulins. The TCR variable domains have three hypervariable regions, which appear to be equivalent to the CDRs in immunoglobulin light and heavy chains. The majority of T cells in the human express T-cell receptors. 41 Immunology T CELL RECEPTORS (TCR) The T-cell receptor is closely associated with the CD3, a complex of polypeptide chains involved in signal transduction forming the TCR-CD3 membrane complex. CD3 is a complex of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (), a heterodimer of delta and epsilon chains (), and a homodimer of two zeta chains () or a heterodimer of zeta and eta chains (). 42 Immunology T CELL RECEPTORS (TCR) Schematic diagram of the TCR-CD3 complex, which constitutes the T- cell antigen-binding receptor. 43 Immunology GENETICS OF (TCR) TCR germ-line DNA is organized into multigene families corresponding to the , , and chains. Each family contains multiple gene segments. The mechanisms that generate TCR diversity are generally similar to those that generate antibody diversity. The chain, is encoded by V, J, and C gene segments. The chain is encoded by V, D, J, and C gene segments. 44 Immunology GENETICS OF (TCR) 45 Immunology CYTOKINES Low-molecular-weight proteins that are produced and secreted by a variety of cell types. They play major roles in the induction and regulation of the cellular interactions involving cells of the immune, inflammatory and hematopoietic systems. Cytokines bind to specific receptors on the membrane of target cells, triggering signal-transduction pathways that ultimately alter gene expression in the target cells. 46 Immunology CYTOKINES The susceptibility of the target cell to a particular cytokine is determined by the presence of specific membrane receptors. A particular cytokine may bind to receptors on the membrane of the same cell that secreted it, exerting autocrine action; it may bind to receptors on a target cell in close proximity to the producer cell, exerting paracrine action; in a few cases, it may bind to target cells in distant parts of the body, exerting endocrine action. 47 Immunology 48 Immunology CYTOKINES Cytokines fall into one of the following families: hematopoietins, interferons, chemokines, and tumor necrosis factors. Cytokines act by binding to cytokine receptors, most of which can be classified as immunoglobulin superfamily receptors, class I cytokine receptors (also known as the hematopoietin receptor family) , class II cytokine receptors (also known as the interferon receptor family), members of the TNF receptor family, and chemokine receptors. 49 Immunology CYTOKINES 50 Immunology CYTOKINES 51 Immunology CYTOKINES 52
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• Buy your licenses, renew boats, and report and see your harvests online!
• Always know when sunrise and sunset is in your neck of the woods
• Find a WMA, Check Stations, Hunters for the Hungry Processors, Fishing Spots, Boat Ramps, and Wildlife Viewing Areas near you (and even get directions)!
• Upload your favorite trophy to the TWRA's online Trophy Room
• Keep a Hunter's Diary to remember your special moments in the woods and access your harvest log anytime
• Catch the latest fishing reports and identify your fish with our Fish ID Guide
• Learn more about Tennessee's Watchable Wildlife
• Browse through delicious wild game and fish recipes
• Stay connected to the TWRA through our social media outlets at Facebook, Twitter, & YouTube
• And even more!
*Created in collaboration with One-Click Outdoors (www.1clickoutdoors.com)
What the Hunt Tennessee
NOTE: If you're not happy with the App, please contact us! We're finding some are leaving negative feedback without understanding how to use the App!
If you press "See All Game" from inside the app you'll see every species listed. Many of these will contain dates for the 2012 season as a reference. As soon as the new dates have been published we will be making the appropriate updates.
See the Tennessee hunting seasons at a glance, organized by date OR by game. Have you ever been turned around on the TWRA website while trying to find out what you can hunt on a certain day but find that the site is organized according to species? We've turned that on its head and allow you to select your date and we'll show you what is available to hunt that day. Plan your vacations, see what is available to hunt this upcoming weekend, or check it while in the woods! Internet access is not required to use the app, just to download the periodic updates when you're within range. The app also gives you Sunrise/Sunset times for any date your planning for.
Each version of the app will get you access to 1 year of updates. At the end of the year your data will NOT disappear. So if you purchase the 2013 version of the app then on 01/01/2014 your app will stop downloading updates but you will still see all published dates in 2013.
Whether you hunt deer, ducks, turkey, or anything else- this App will help keep you on track!
This app is not endorsed by the Tennessee TWRA.
Tennessee Titans Mobile
Now, you can stay in touch with the Titans anytime, anywhere, on your Android device.
Features include:
- News: Real-time breaking news from the Titans , previews of upcoming matchups, post-game blogs
- Video: Video-on-demand clips of the Titans' press conferences, coach and player interviews
- Photos: Gallery of game-time action
- Stats: Real-time statistics and scores from the official NFL stats engine, head-to-head stats of the matchup, player stats, drive-by-drive stats, box score, out-of-town scores around the league
- Standings: Division and conference standings
- Fantasy: Keep track of your favorite fantasy players
- Depth chart: Shown by offense, defense and special teams
- Social media: Aggregated twitter of the Titans' official tweets, check in to the stadium on game-day, one-click tweet of all media items, one-click facebook posting of all media items
- Schedule: Schedule of upcoming games, and scores/stats of previous games from the season, ticket purchase for games
- Evolving home-screen: Pre-game, in-game, post-game, off-season countdown, draft-day
Follow us @yinzcam on Twitter for updates or to ask questions and provide feedback.
Whitetail Deer Calls
Use an external speaker for best sound quality.
Be sure to rate this app.
Thanks for downloading!
Current Calls:
Doe Contact
Doe Grunt
Buck Grunt
Tending Grunt
Buck Bawl
Rage Grunts
Estrus Bleat
Breeding Bellow
Aggressive Rattling
Bucks Fighting
Fawn Bleat
Fawn Bleats
Fawn Distress
Hunting Calls Free
Deer Turkey Predator Calls:
Save Sounds, Set as Ringtones/Notifications!!!
Just press on the call you want to set as a ringtone/notification files are saved to
Hunting Calls are loud and have excellent quality!!
Easy layout for use in the field and is super fast!!
Over 50 HD hunting calls!!
Deer Calls-grunts, bleats, wheeze and many more!!
Predator Calls-cottontails, howls, squeals, and many more!!
Turkey Calls-yelps, purrs, clucks, and many more!!
More Calls Will Be Added Soon!!
Turkey Hunting Calls
Designed with hunters in mind. Play, Stop or Change calls on the run from Big and clear buttons.
Check your local game laws for legal use if you intend to use this in hunting.
Free Field Caller - Deer Calls
Please email us any pictures of the deers you have taken using this app. We will be more then happy to host them on our website.
"so last Saturday I'm in the tripod trying to grunt in... well anything. I figure I need a doe Bleat to make the call more realistic. so I found this app and figured what the heck, I'm not seeing anything without it so it can't be worse. anyway, I used the doe Bleat, and followed with 2 soft grunts. about 30 seconds later this buck comes full speed right for the tripod. I got a shot and downed it. I had been grunting all morning and this app got me my buck!" -A. Plumley
This is the free AD supported version of this app. You can get this app without ads at http://market.android.com/details?id=gamecaller.laroche.com
Please be aware, for this app to be offered to you for FREE then the app does display ads to help compensate the developer for the work that went in to developing the app. Please do not leave negative comments because the app has ads. You have been informed before installing the app.
*8 high quality deer calls
*Simple and easy to use
*Over sized buttons for easy playback
*Doe Bleat
*Doe Estrus Bleat
*Buck Grunt
*Buck Dominant Grunt
*Tending Buck Grunt
*Buck Snort
*Bucks Fighting
*Fawn Distress
Please note, that some phones and tablets can not reproduce these high quality sounds correctly. If you are not satisfied with the quality of the sounds, then I would recommend getting an external battery powered speaker.
Amazon has a great portable battery powered speaker that I use, and recommend. You can find this product at http://www.amazon.com/gp/product/B003Y7PXSK/ref=as_li_ss_tl?ie=UTF8&tag=goldrecy-20&linkCode=as2&camp=217145&creative=399369&creativeASIN=B003Y7PXSK
Tennessee Volunteers Gameday
Features Include:
+ LIVE GAME AUDIO - Listen to free live audio for all football and men's basketball games
+ SOCIAL STREAM - View and contribute to real-time Instagram & Twitter feeds from the team and fans
+ FAN GUIDE - The official Gameday Fan Guide with key times, events, and the need-to-know information to plan your gameday
+ INTERACTIVE STADIUM MAPS - Enhanced location aware in-venue maps for fans, with key points for Neyland Stadium, tailgating and parking
+ SCORES & STATS - All the scores, stats, and play-by-play information that fans need and expect during live games
+ SEC and TOP 25 SCORES – Live scoring from across the conference and Top 25
+ ALERTS - Custom alert notifications to let fans know everything surrounding Gameday
iHunt: 600 Hunting Calls
Why spend over $200 for an electronic caller in the stores when you can get this app for less than the price of *batteries* for one of those callers? We're #1 for a reason; download the app now and you'll see why!
★★★ #1 SELLING HUNTING APP ON ANDROID AND iOS FOR OVER 3 YEARS ★★★
✔ Unmatched selection of 47 animals and 600 hunting calls to choose from! (Scroll down for a list of them)
✔ High quality calls with no audio noise!
✔ Custom hunting playlists allow you to create truly unique calls or long, repeating hunting playlists for each target species. We are the ONLY hunting app out there that offers this feature!
✔ Easily set advanced repeat, delay, and volume settings for each hunting call
✔ Set playlists to automatically repeat when they reach the end for hands-free operation
✔ Choose whether calls can overlap each other or if they play sequentially (one after the other)
✔ Supports playing through external loud speakers!
✔ Make an educated purchasing decision - Free to try, cheap to buy!
★★★ Have an iPhone/iPod/iPad? Get the iOS version! https://itunes.apple.com/us/app/ihunt-sounds-calls-create/id386882057?mt=8 ★★★
Alligator & Crocs - 26 calls
Bears - 12 calls
Birds - 18 calls
Bobcats - 13 calls
Buffalo & Bison - 6 calls
Chicken - 12 calls
Chipmunks - 4 calls
Cows - 11 calls
Coyote - 54 calls
Crows & Raven - 32 calls
Deer - 40 calls
Donkey - 7 calls
Duck - 29 calls
Elk - 30 calls
Fox - 19 calls
Geese - 18 calls
Goats - 5 calls
Hawks & Eagles - 14 calls
Mice & Rats - 10 calls
Moose - 26 calls
Owl - 22 calls
Pheasant - 7 calls
Prairie Dog - 8 calls
Quail - 13 calls
Rabbit & Hare - 22 calls
Raccoon - 9 calls
Sheep & Lamb - 8 calls
Snipe Bird - 9 calls
Squirrels - 17 calls
Turkey - 37 calls
Wild Boar & Pigs - 20 calls
Wildebeest - 6 calls
Zebra - 8 calls
Think you can find this many quality sounds and calls anywhere else? Think again. We spent hundreds of hours cleaning up these sounds to give you only the best to bring out to the field.
Got a favorite sound or call you want us to add to the app? Send it to firstname.lastname@example.com and we'll do our best to remove the noise and add it in future updates. Please be advised that by sending the file, you release all rights to us for full use and disclosure to others.
Best of luck and happy hunting!
Like us on Facebook: https://www.facebook.com/iHuntCalls
◆◆◆ We've been the #1 selling hunting app for over 3 years now! Forget about the rest and go with the best: iHunt! ◆◆◆
ScoutLook DeerLog
***** We are pleased to announce the release of the updated version of DeerLog. This update addresses the stability issue experienced by users with older devices, as well as location detection, and Null information in certain locations. We are completely committed to world class hunting weather tools and customer service, and we thank you for your understanding and support! *****
DeerLog automatically captures time, date, gps location, weather details, wind and moon info at time of sighting and enables real time deer logging in drop downs with NO TYPING! Review logs on phone or PC since data synchs with FREE account at ScoutLookweather.com: Automatically tracks buck to doe ratios and buck age structure by stand or property! Sort logs by all data fields to see what works, when and why, or export to Excel for further use. It's a Deer Log like nothing you've ever seen!
Hunting Clubs, Outfitters & Landowners – Create personalized access codes so all hunters on your land can log all sightings & conditions at every stand to your private log database. Monitor your deer herd and hunting activity on your land, and know what conditions work best all stands with this user-friendly, intuitive and powerful tool.
ScentConeSM Wind Map displays speed and direction at your hunting locations for 72 hours!
ScoutMarXSM saves key locations in the field: Scrapes, Rubs, Bedding, Food, Water Holes, Blood Trails, Camera sites, Feeder/Attractant sites, Trail Crossings, Topographic pinch points, parking areas, etc. all pinned to the satellite map for later reference, weather or wind checks, or logging of Deer!
ScoutLookweather.com is the ONLY major weather website that is owned and operated exclusively by hunters! Scoutlook is a FREE online service providing pinpoint, map-based weather details, wind map tools, solunar times, lunar phase, tides, hourly barometric changes, and a log book to help hunters to decide where, when and how best to hunt or fish. Login from your App or online and get all you need to know, from one resource, before you head out!
Currently, ScoutLook weather provides maps and weather data for the continental United States.
Tennessee Vols Live Clock
*Includes live scores for all regular season college football and basketball games, as well as Bowl Games, the NCAA College Football Playoff, conference tournaments and March Madness.
*2014-2015 schedules and scores are in the clock. If you don't see them, please update your app!
Subscription: This is an officially licensed product with royalties paid to the University of Tennessee. The $2.99 annual subscription is good for 12 months from date of purchase (after the free trial ends). If you don't like it, just cancel your subscription within 7 days and you won't be billed. To manage subscriptions, launch the Google Play Store app, then tap Menu > My Apps > Subscriptions.
- Includes 3 layouts: Flip Clock, Scoreboard & Analog. (Scoreboard does not appear on the clock face with Analog, but you can still tap for scores).
- Tap the widget to see detailed scoreboard, schedule and news by conference
- With the widget open, tap the conference name to view other conference schedules, or tap the week number to view schedules for different weeks.
- Scoreboard will appear below the clock when games are on. In landscape mode, scores appear beside the clock.
- We don't have room to show every game below the clock. To see more games, just tap the clock and select the Scores tab.
- To see other apps & widgets for other teams, tap "More by Smartphones Technologies, Inc."
INSTALLATION INSTRUCTIONS: This clock is a widget, not an app. To add the clock to your home screen, follow the installation instructions below:
OS 3.0 versions: After downloading: (1) go to Menu > Notifications to install; (2) tap and hold on your home screen and select Widgets to add it to your phone. Tap the widget to see the latest conference schedule, news or scores, or to change user options.
OS 4.0 and above: On your Home Screen, go to Apps > Widgets, then swipe over until you see your clock widget. Then tap and hold to drag it to the selected location on your home screen. If it doesn't work, make sure you have enough available space (you may need to move other icons). The space required is 4 wide x 2 high.
Time Zones: Schedule times are displayed based on the time zone set on your phone. When you change time zones, the scheduled times displayed in the widget will automatically adjust.
A Note on Live Scores: The scores on your clock will always be slightly behind the actual game time. Unfortunately, we can't change the laws of physics. It takes a few seconds to enter the scores into the computer, go out to the server, come back to our server, and finally out to your phone. If you're already watching the game live, just enjoy the game!
Warning: If you're using a task killer, make sure you add the schedule widget to the exceptions list or it will kill the schedule updates.
Whitetail Hunting Calls
Designed with hunters in mind. Play, Stop or Change calls on the run from Big and clear buttons.
Check your local game laws for legal use if you intend to use this in hunting.
GoTrapping! is an app designed to support the recording and analysis of trapping data. The app allows the trapper to record set type and location and catches made at those sets. Set types, traps, lures, and baits can be added or deleted as needed. Targeted species can also be added and deleted. The app provides the ability to analyze set performance in a variety of ways so that the user can determine the best sets to make for targeted species as well as have a record of catches and sets.
The app is intended to be used in the field so that location can be automatically captured through the devices GPS. When a catch is made, if the app is opened at the catch site, it will also automatically identify the set using the GPS so that data can be recorded quickly and accurately.
New: This version adds a number of new features requested by users.
1. The ability to add sets via the start map. Simply zoom in to the spot, press and hold until icon appears, and then tap icon to fill in details.
2. The ability to add scouting locations. Change the start map mode to scouting. Add the location by zooming and pressing and then add details and notes.
3. The ability to name sets. This feature can be turned on and off.
4. The ability to group sets into traplines. This feature can also be turned on and off to fit your needs.
5. The ability to use a trap inventory. You can add your traps and the number of them you have. When you make a set, the inventory amount of that trap and size is decreased. When you pull a set the inventory is increased. This feature may also be turned on and off.
6. Increased user control about what type of sets are displayed on the start map and deleting sets.
7. The ability to use the app for scouting. When Scouting mode is selected Potential sets are specified by color on the map.
Hunting Call
Go hunting? Get Hunting Call before you leave. This app can produce the sound to call most small game and big game animals. Each sound was made to be crystal clear.
Additional Features:
Long press to set your favorite call/sound to your ringtone /notification.
If you intend to use the calls for hunting, check first your local game laws for legal use.
Including calls
Deer: Grunt Bawl Alert Wheeze
Snort Wheeze
Social Grunt
Tending Grunt
Doe Grunt
Estrus Bleat Mild
Estrus Bleat
Fawn Distress
Fawn Grunt
Young Buck Grunt
Waterfowl: Bufhead duck, Canada goose, Greylag goose, Mallard, Pintail duck, Snow goose, Teal, Widgeon, Wood duck | cluck, greeting, hail, laydown, moan, feeding, comeback ...
Bird: Bob White Quail, California Quail, Crow, Owl, Pheasant, Turkey | assembly, 2 syllable, 3 syllable, cluck, cutting, purr, gobble, kee kee ...
Elk: elk cow, elk calf, elk bull | bark, talk, grunt, bellow...
Predator / varmint: bobcat, coyote, fox, wolf, Raccoon | distress, change bark, chatter howl, greeting howl, locator, talk, squeak
Specialties:Jack Rabbit, Javelina, hog, squirrel, cottontail, javelina
Currently there are over 80 high quality calls and increasing...
GForce Deer Call Generator
The "Call Of The Wild" on your phone! The nation's most popular big game has recently been discovered to be quite a vocal animal. Snorts, grunts, and bleats make up the majority of the deer's communication. Making the correct call at the right time is key to luring in wild deer. The rhythm, inflections, and tones must be accurate. The GForce Deer Call Generator reproduces nine of the most common vocalizations deer use to communicate.
All sounds have been optimized for maximum volume and sound quality without distortion to provide an optimum deer hunting experience. To increase the range beyond your android device's capabilities, use an external amplified speaker (use carefully, since calling too loud can be interpreted by deer as yelling!)
Master the sounds as you practice your manual deer call, fine tune your deer calling by mimicking the electronic deer call in the field, or use the deer call recordings to lure deer in close (check state game laws for legal use). This app is a deer hunter's "must have" and adds a practical tool to the deer hunter's calling system.
An on-screen quick reference guide is provided below each deer call with quick, easy to read instructions for each call's optimum frequency and time of use during pre-rut, rut, and post rut. Novice or expert, the GForce Deer Call Generator lets you make the right call at the right time, every time.
Nine must-have calls in a single app:
1. Buck Grunt
2. Buck Bawl
3. Doe Contact Call
4. Doe Grunt
5. Doe Bleat
6. Doe Estrus Bleat
7. Doe Breeding Bellow
8. Fawn Bleat
9. Fawn Distress
Helps both the novice and seasoned hunter call in game. When it's time to call, scroll to the sound you want and push the corresponding button. Easy one-hand operation keeps movement to an absolute minimum. Great for downwind calling or when trying to precisely position a buck for a perfect shot. All the advantages an electronic deer call can offer are yours with the GForce Deer Call Generator.
Tennessee Fishing Maps - 12.5K
-Complete library of over 12,500 fishing locations (lakes, rivers, reservoirs and wetlands).
-Fishing locations are searchable by name, or easily retrievable by clicking a county to see all lakes or other features in this geography.
-Save a lake or river on your favorites list for easy access to your favorite fishing spots.
-Create a journal entry for each fishing experience at a lake, river, stream, reservoir or wetland (swamp).
-Can't remember a lake name, the app allows you with ease to review all lakes, rivers, reservoirs or swamps for counties in Tennessee.
-Want to share your fishing experiences with your fishing buddies, with one simple click you can email or text (SMS) lake or river details with GPS data to friends.
This is a must have app for all fishermen and fisherwomen who love to explore the great waters of Tennessee (TN).
iFish Tennessee
Now you can easily access detailed information on over 1,300 Lakes, Ponds & Reservoirs throughout Tennessee. Get real-time Lake Reports, Weather Conditions and Best Fishing Times. Review and mark your favorite HotSpots, and learn tips, tricks and techniques.
Impressive Feature List:
✔ Access over 1,300 Lakes, Ponds & Reservoirs
✔ Easily Search a Lake with only a few letters
✔ Proximity Search to find a Lake near you
✔ Proximity search from a City, Town or Lake
✔ View & add HotSpots at your favorite Lakes
✔ Share your HotSpots or keep them Private
✔ View & add Live Lake Reports & Feedback
✔ Books, Mags & More – Save for Offline Reading
✔ Solunar Calendar to show Best Times to Fish
✔ Real-time Weather Conditions
✔ 4-Day Weather Forecasts
✔ View Nearby Photos at every Lake
✔ Species Reference with detailed info & images
✔ Access to State regulations & license information
✔ View maps & get directions to every Lake
✔ Link to numerous resources
✔ Great Fishing Tips, Videos & How To's
Get the App that every angler needs and Fish with Attitude !
Visit www.iFishTennessee.com for the latest Features, News, Coverage or if you have any questions or feedback!
More from developer
Pick Tennessee
This free mobile app keeps track of your favorites and links you to seasonal recipes, handy tips and fun facts as well as the full Pick Tennessee Products website, PickTnProducts.org. Some of the great farm direct and local items you can find on this app include local fruits and vegetables, wineries, greenhouses and plant nurseries, Christmas tree farms, plus local honey. You can find the farms where they're produced, or the markets where they're sold.
Pick Tennessee Products is the longstanding statewide campaign by the Tennessee Department of Agriculture to connect customers to locally grown or made products and farm-related activities. The completely free service currently lists about 2,000 farmers with about 10,000 items. Visit PickTnProducts.org to find out for yourself all the good things growing and going on near you!
kidcentral tn
•Create and access your parent profile on the go
Create your own profile, access your bookmarked helpful articles and save state services from your smartphone.
•Find state services from anywhere
With our app, you'll get mobile access to state services, receive directions to locate services, and find important contact information, no matter where you are.
•Use the kidcentral tn refrigerator magnet
Save all your child's important information and emergency contacts to have with you at all times. Then share that information with babysitters, educators, doctors or whomever you choose.
TN Restaurant Inspection
- Browse nearby restaurants, or search for a specific place
- Save favorite restaurants to quickly see their scores
- Filter search results by a range of allowable scores
- Updated daily with most current inspection information
- Also shows inspection scores for schools and hospitals


text:
Fewer young bobbies on the beat in Cumbria
Last updated at 17:12, Wednesday, 23 January 2013
THE number of young police officers in Cumbria has dropped dramatically, with figures revealing a near 60 per cent fall in three years.
Statistics show there were 65 bobbies aged under 26 in the county in 2009/10 – but there were just 27 in the last financial year.
Overall police numbers have fallen in recent years following tighter budget constraints.
There have been freezes in recruitment and relatively small amounts taken on when new recruits are brought in.
The results mean only two per cent of officers fell into the under-26 age range in the last financial year – only one per cent more than those aged over 55.
Lee Skelton, chairman of the force union, Cumbria Police Federation, said this was "easily attributable" to the recruitment situation in recent years.
"We are also tending to see a trend in that people have been joining the police service later in life," he said.
"Recruits don't tend to be 18 or 19-year-olds, they tend to be in their 20s and 30s."
Mr Skelton added it was disappointing "young blood" was not coming through as the force should represent every social group, adding the federation had expressed concern about "the aging profile of the beat police officer".
A raising of the retirement age to 60 could also mean frontline officers of that age "wrestling with people on the streets".
"That's far less appropriate than someone in the prime of their youth in peak physical condition," he added.
But Mr Skelton said there was still a high quality of recruit coming into the job and that life experience also counted.
"Confrontation and physical action is a last resort," he added.
"The most important aspects for us are communication and nouse."
Nationally, the number of young police officers in England and Wales fell by nearly 50 per cent in the same period.
A Home Office spokesman said: "Recruitment is a matter for individual forces and it is for chief constables and police and crime commissioners to ensure they have the right mix of officers.
"Police officers play a vital role in this country, fighting crime and keeping us safe.
"Our reforms are working – crime is falling and public confidence is high."
First published at 16:20, Wednesday, 23 January 2013
Published by http://www.nwemail.co.uk
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Explore the ruins of Hadley's Hope and many other areas following the events in the Aliens movie.
Aliens: Colonial Marines: Hadley's Hope interior trailer
Aliens: Colonial Marines 360
- Developer
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- 12 February 2013
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Wahoo P4 Stratagem System Review 323
from the test-driving dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
Equivalent watercooling System: $300
Enermax 550W Quiet Power Supply: $180
Case Fans: $20 (They're using panaflo L1A's for everything, an excellent choice for a watercooled system, but yes they really are this cheap)
Babybus: $40
Pentium4 3.0ghz
2x HDD Cooler: $25
Top of the line Granite Bay Motherboard: $200 (includes intel 10/100/1000 ethernet)
2x Sticks of 512mb Insane DDR of a brand of your choice : $400
Radeon 9700 pro : $270
Sound Blaster Live! Audigy Platnium : $200 (To anyone considering this -- DO NOT BUY IT -- go with terratek if you truly care about sound!)
2x WD1200JB Hard Drives: $280
Plextor CD-RW + HP DVD+RW Drives : $450
Zip Disk + Floppy: $35
Hardware Modem: $50
WinXP Pro: $170
Total: $3662
That is a FREEGING HUGE PRICE DIFFERENCE. Your paying about $3000 for the case plus them putting it together. I mean, I know that there are people willing to pay quite a premium for a well built system they don't have the time to research -- but jesus chrirst $3000 is nuts. This article is just more free advertising for some random company.
You know you've landed gear-up when it takes full power to taxi.


text:
Steak with Wine
Source: dLife
Steak slow cooked with a delicious combination of wine and vegetables.
1 1/2 lb Beef, bottom round outside steak, lean, raw, 0" trim
2 each medium carrots
2 each medium celery stalk
1 cup fresh mushrooms
4 each fresh green onions
14 1/2 oz canned Italian style stewed tomatoes
1 cup fat free unsalted beef broth
0 1/2 cup Wine, red, Sangiovese, 5 fl ounce serving
1 tsp italian seasoning
0 1/2 tsp salt
0 1/4 tsp black pepper
1 each bay leaf
3 tbsp cornstarch
3 tbsp cold water
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