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Create simple animation for website and youtube,
Closed - This job posting has been filled.
Job Description
Please refer to website http://eurobind.com.ar/demo.php
I need to create a VERY similar animation that can be uploaded onto my website (www.winbind.com.au) and also youtube. Please ensure the format you are suggesting would be suitable for both youtube and my bigcommerce website.
The graphics in this animation is perfect however I need to be able to dub audio over it and also place english wording instead of the current wording. I will supply and load the Audio, however will need you to insert the english wording I will supply.


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Pronunciation: emporio
Added on: 2012-03-15 Listened: 112 timesin: Add categories to emporio
Pronunciation in Spanish [es]
- Pronunciation by nancyleticia (Female from Mexico)
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emporio pronunciation in Italian [it]
- Pronunciation by silviaparisini (Female from Italy)
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- Random word: Peñíscola
by Wiktionary Phonetic spelling:
by Google Translate English translation:
emporio = emporium
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subset: commoncrawl


text: If I had wings, I'd fly. Being more earthbound, I currently am raising batch number two, out of four, but enjoy sneaking off with my older children to places we've only dreamt about through our literary excursions, favourite period films, and love of art & history! My favorite place is at the piano, reading, hiking, writing and enjoying good food with those I treasure. I love travel, and I'm a courteous and grateful houseguest!


text:
dig·i·tal \Èdi-jY-tYl\ mar·ket·ing \Èmär-kY-tiK\ 1 : The promotion of products or brands via one or more forms of electronic media. (businessdictionary.com)
One of the biggest challenges companies face today is finding digital marketing professionals that can create data driven, integrated Digital Marketing Strategies that attract customers and grow their business. A full 54% of executives believe their marketing team is not equipped to handle new trends and technologies (Aquent/American Marketing Association Marketing Salaries Survey)
Digitize your marketing skills today! Learn from industry experts through hands on, interactive activities and discusions, yielding deliverables you can take to your management team.
Candidates for the Digital Marketing Certificate should have a degree in marketing or related field and/or two years of marketing related experience. Small business owners are also welcome. The courses in this program do not focus on basic marketing concepts.
Courses can be taken towards the Digital Marketing Certificate or individually.
Connect with theSchool of Continuing Education
Adobe Illustrator - Basics
Thu., Apr. 30
Building an Effective Digital Content Strategy
Fri., Apr. 17-May 1
Capstone - Digital Marketing Certificate
Tue., July 1, 2014-June 30, 2015
Cascading Style Sheets Part II
Sat., May 9
Creating a Social Media Content Plan for your Organization - Content Production and Syndication
Course Accessible: Mar. 16-29
Deliver the Right Message at the Right Time with Marketing Automation and Personalization Technology
Wed., May 20
Digital Analytics Strategy: A Structured Approach to Measuring, Interpreting and Reporting Data
Fri., May 1-22
HTML Part II
Sat., Apr. 18
Listening and Monitoring Strategies for Social Media
Course Accessible: Apr. 27-May 10
Reaching Your Target Audience Through Paid Media
Fri., June 5-26
SEO (Search Engine Optimization) - Definitive Guide to Higher Ratings
Fri., Apr. 24
Social Media Analytics - Tracking, Measuring and Reporting
Course Accessible: June 8-21
Writing Web Content That Works
Course Accessible: June 15-28
Marketing & Technology Spring 2015 Brochure
Or download the pdf
Digital Marketing Certificate
Download the PDF


text:
A yellow-and-black jumpsuit worn by Bruce Lee in the movie "Game of Death" fetched more than $100,000 in Hong Kong, at an auction of memorabilia related to the star's life and career. Read More »
Dec 6, 2013
A yellow-and-black jumpsuit worn by Bruce Lee in the movie "Game of Death" fetched more than $100,000 in Hong Kong, at an auction of memorabilia related to the star's life and career. Read More »
A yellow-and-black jumpsuit made famous by martial-arts star Bruce Lee is expected to fetch as much as 300,000 Hong Kong dollars (more than US$38,600) at an auction Thursday in Hong Kong. Read More »
A new exhibition in Hong Kong is taking an in-depth look at the life and legacy of martial arts icon Bruce Lee. Here's a sampling of what's on display. Read More »
A new exhibit in Hong Kong takes an in-depth look at the life and legacy of Bruce Lee, who become an international star with kung-fu movies such as "Fist of Fury" and "Enter the Dragon." Read More »
Times are tough in China for whiskey makers, hit hard by a government crackdown on luxury gift giving. So tough, in fact, that Johnnie Walker has turned to resurrecting the likeness of movie icon Bruce Lee to sell its Scotch in an online video advertisement. Read More »
Is that Bruce Lee you're wearing?
Bruce Lee Enterprises, the business arm managing the late martial-arts star's legacy, this week launched a line of colognes in Dubai bearing Mr. Lee's image and name.
Shannon Lee, his daughter and the head of the company, said the collaboration came about when she met Chkoudra Paris, a French fragrance firm, at a licensing show about a year ago.
The American painter Roy Lichtenstein's fascination with ancient Chinese art is the subject at Gagosian's Hong Kong gallery. And will Seattle get its own Bruce Lee museum before Hong Kong? WSJ's Jake Lee and Jason Chow discuss. Read More »
A museum dedicated to Bruce Lee may happen after all — in Seattle, not Hong Kong.
City officials, according to local reports, recently put forth a proposal to examine the possibility of a museum dedicated to the martial-arts star. The Bruce Lee Foundation, which is headed by his daughter Shannon, has developed a concept for what would be called the Bruce Lee Action Museum and envisions a building that would house memorabilia and personal items from his life. Read More »
Memorabilia from the life of Bruce Lee, including a handwritten letter and a coat custom-made for the actor, will go under the hammer in Mr. Lee's hometown of Hong Kong on Saturday.
The 13 items are expected to fetch up to 880,000 Hong Kong dollars (US$113,000). Read More »
Efforts to build a Bruce Lee museum in the late kung fu movie star's hometown of Hong Kong have been stalled again.
Fans have been calling for an official tribute to the screen icon for years. Their hopes appeared to be answered two years ago when the Hong Kong government and the owner of Mr. Lee's former home reached an agreement to convert the property — a two-story house currently used as an hourly love motel — into a museum. Read More »
China's territorial ambitions in the East and South China seas are by now well-documented. Much less understood is one of the key factors in the country's ability to realize those ambitions: an increasingly well-funded and capable maritime militia.
China now has a key tool for sidestepping weak government enforcement of pollution controls, but only if it's allowed to function as intended.
The U.S. has been urging allies to steer clear of Asia's new China-led infrastructure investment bank. Robert Zoellick, former president of the World Bank, calls that approach mistaken on multiple levels.
Can legal reform and Communist Party control coexist in a way that will benefit Chinese governance and society?This is the question that confronts the country in the wake of its annual legislative gathering.
China's just-concluded legislative sessions seem to be another example of the deinstitutionalization of politics under Xi Jinping. Months from now, these meetings won't be seen as harbingers of reform, so much as another lost opportunity, writes CRT analyst Russell Moses.
Content engaging our readers now, with additional prominence accorded if the story is rapidly gaining attention. Our WSJ algorithm comprises 30% page views, 20% Facebook, 20% Twitter, 20% email shares and 10% comments.
China Real Time Report is a vital resource for an expanding global community trying to keep up with a country changing minute by minute. The site offers quick insight and sharp analysis from the wide network of Dow Jones reporters across Greater China, including Dow Jones Newswires' specialists and The Wall Street Journal's award-winning team. It also draws on the insights of commentators close to the hot topic of the day in law, policy, economics and culture. Its editors can be reached at firstname.lastname@example.com.


text:
Floor Plans and Pricing
1 Bedroom
|1 Bathroom
|720 Sq. Ft.
This 720 sq. ft. 1 Bedroom, 1 Bath features inviting amenities. Many of our floor plans feature large windows where you can gaze on a DC Neighborhood View.
|$1621 - $1704
|1 Bathroom
|765 Sq. Ft.
This 765 sq. ft. 1 Bedroom, 1 Bath features inviting amenities. Many of our floor plans feature large windows where you can gaze on a DC city view.
2 Bedrooms
|2 Bathrooms
|995 Sq. Ft.
One whole wall of this apartment are windows. In the bedroom and living room, sunlight flows in throughout the day, making your apartment generally more bright and saving money on lighting.
|2 Bathrooms
|1100 Sq. Ft.
This gorgeous layout offers a large amount of space with a urban feel. Step out on your balcony for a taste of the city life here in downtown DC!
|$2995 - $3241
|2 Bathrooms
|1229 Sq. Ft.
Property Features
- Property Overview
- Special Features
- Community Features
- Apartment Amenities
- Local Schools
- Pet Policy
AVA Van Ness in Washington, DC
AVA Van Ness offers apartments for rent in Washington DC in the heart of a fabulous Van Ness neighborhood at the entrance of Rock Creek with convenient shopping and dining options, and just steps from the Metro. These 1 and 2 bedroom apartments feature private balconies or patios, massive closets, separate dining areas, step down living rooms, wall-to-wall carpeting, and modern appliances. Apartment common ares include social spaces like an outdoor chill area featuring BBQ grills and games, tennis court, comfy seating for hanging out with friends or chilling alone, and an outdoor pool with sundeck. There is also an awesome fitness center, garage parking and bike storage.
Special Features
- Flexible Lease Terms
- 24-Hour Fitness Center
- 24-Hour Resident Concierge
- Garage Parking Available
- Expansive Closets & Storage Space in select homes
- Pet Friendly
- Sundeck with Grills
- Cutting Edge Business Center
- Tennis Court
- Separate Dining Room
- Plush Wall-to-Wall Carpet
- Abundant Closet Space
Community Features
- Apartment
- Business Center Onsite
- Fitness Center
- Garages
- Laundry Facility
- Mid Rise
- Pool
Additional Information
Year Built: 1978
Apartments in Community: 268
Apartment Amenities
- Air Conditioning
- Cable or Satellite
- Carpet
- Ceiling Fan
- Dishwasher
- Garbage Disposal
- Microwave
- Patio or Balcony
Local Schools
- Deal Middle School
- Hearst Elementary School
- Wilson Senior High School
We believe school data to be accurate, but do not guarantee that. Please be sure to verify where your children will attend school before making your housing decision.
Pet Policy
Maximum of 2 pets per home. Dog weight limit is 200 lbs. Additional rent for pets is $50 per month. The pet deposit is $500.
- Pets Allowed
Contact AVA Van Ness
AVA Van Ness
Office HoursMonday 9:00 AM-6:00 PM Tuesday 9:00 AM-6:00 PM Wednesday 10:00 AM-7:00 PM Thursday 9:00 AM-6:00 PM Friday 9:00 AM-6:00 PM Saturday 9:00 AM-5:00 PM Sunday Closed-Closed
1 and 2 Bedroom apartments for rent in the heart of a fabulous Van Ness neighborhood at the entrance of Rock Creek with convenient shopping and dining options, and just steps from the Metro in Washington, D.C.
Driving Directions: Directions to The Consulate From Washington DC Take Connecticut Avenue north to Van Ness Street. Turn right on Van Ness Street. The Consulate is on your right. From I-495 Take Connecticut Avenue south to Van Ness Street. Take a left. The Consulate will be on your right. From Metro Take the Red line to the Van Ness / UDC stop. Exit the station using the East Side of Connecticut Avenue NW / Veazy Terrace exit. Walk approximately one block on Connecticut Avenue NW to Van Ness..
As you search for your perfect apartment, please keep in mind that rental rates (including specials and discounts) and availability are very fluid in the apartment industry. Based on many factors, the rental rates (including specials and discounts) and availability can actually change not just daily, but hourly, if not even more quickly. While our advertisers do take steps to keep their information current, the rental rates or availability you may find here now at ForRent.com may not be the same as when you contact the communities.
Quick Links For Your Apartment Search
- Washington DC metro
- Downtown DC area
- Washington
- 20008
- See Also


text:
Police mark decade since teen's disappearance
MONTGOMERY Vermont police say investigators are still receiving tips about the 2004 disappearance of 17-year-old Brianna Maitland, last seen when she left her job at a Montgomery inn.
Wednesday is the 10th anniversary of Maitlands disappearance.
Police say there is a strong likelihood that Maitland was the victim of a crime.
Maitland was last seen when she left her job at the Black Lantern Inn in Montgomery at about 11:20 p.m. on March 19, 2004. Her car was found the next day next to an abandoned farmhouse a short distance from the inn where she worked.
Police say there is no evidence she left the area willingly.
State Police Major Glenn Hall says investigators believe someone knows what happened to her.
A $5,000 reward has been offered.MORE IN This Just InNEW YORK Emergency workers found a body Sunday in the mass of rubble left behind by an apparent... Full StoryHALIFAX, Nova Scotia An Air Canada plane made a hard landing short of the runway at the Halifax... Full StoryWASHINGTON The National Security Agency considered abandoning its secret program to collect and... Full Story
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Late July Pictures.
The first and picture is not so attractive but as i never ever planted one i was surprised to see it appear in my garden 12 months ago,..in fact i had never seen one before,..now in July it popped up again,..two of them,..almost 3ft high and the bigger one has a leaf span of 22 inches,..leaves only on the top and the stem has Leopard like markings,..it is "Arisaema speciosum"
the smaller plant is almost hidden within the Dahlia,..the larger plant behind it.
Hemerocallis,var,Daylily,'Little Grapette'.
The garden to which I refer that is so puny is 25 ' from the drip line of those water oaks. But when I dug the bed- it was pure sand. Of course I amended the soil- and 3 x a year- I add compost and cow manure & fertilize every month with miracle grow- also Bayer rose & flower
Hi Cenepk10,
You sure have a lot of work on hand removing those trees and pruning others,..rain you say!,..its a daily sight here with 200 days of rain a year and so when you see my garden pictures many blooms have raindrops on them,..but as you said everything then looks green and lush.
Your arborist is correct about adding Lime to the soil to increase the pH level as it will reduce acidity,..agricultural lime of course,.. as it is made from calcium,..you will see the difference when the acidity level decreases though readings taken soon afterwards can be misleading so take no notice,..your plants will give you better results in growth and blooms.
Thank you so much, Philip- do you have to scratch it in the soil ? Or just spread it around the plants ? He said that low of a ph will burn azaleas. Explains my dead azaleas in back. I have never come up against this sort of thing in my 35 years of gardening. Only time I ever saw lime was in Greece- they would throw it on corpses to kick back the smell in graves & use it to whitewash the concrete houses every spring. Omygoodness. TMI


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Dairy-farm robots replace some workers
Rochester Democrat and Chronicle
A Lely Juno robot pushes feed up close to the hungry herd in the main feed barn at Hemdale Farms and Greenhouses in Clifton Springs.
Via Kalani Kirk Hausman
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text:
"Simplicity is the ultimate sophistication"
- Leonardo Da Vinci
"Good design is obvious.Great design is transparent"
- Joe Sparano
"Design is intelligence made visible"
- Alina Wheeler
Don't Miss our Special offer today.
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text: Meta Battle Subway PokeBase - Pokemon Q&A Login Register All Activity Questions Unanswered Tags Users Ask a Question Rules Chat Recent questions tagged return 1 vote 1 answer 359 views If a wild Pokemon uses Return/Frustration, what would the attack's base power be? asked Jun 1, 2014 by Qwerty_Zoom frustration return attack base-power 0 votes 1 answer 686 views Does Pokemon-Amie affect Return? asked Feb 8, 2014 by LeafeonAndCharizard xy happiness return pokemon-amie 0 votes 3 answers 4,132 views Does happiness affect return in online battles? asked Dec 1, 2013 by Da Togekiss xy return happiness online 1 vote 1 answer 344 views Return/Frustration Damage Formula? asked Nov 27, 2013 by excadrill444 return frustration power formula 0 votes 1 answer 1,339 views Does a Pokemon using return online have to have max happiness to make it a powerful move? asked Nov 27, 2013 by Benwood base-power return happiness xy 0 votes 1 answer 850 views How to max-out Frustration's power? asked Nov 17, 2013 by JoeBlackham happiness return base-power 0 votes 1 answer 337 views If you use the move Bestow successfully, does that item return to you after the battle? asked Nov 9, 2013 by UnknownLegend12 moves battle return 0 votes 1 answer 236 views What is Return's effect when used by a wild Pokemon? asked Nov 5, 2013 by !'•-Indigo-•'! wild-pokemon return happiness mix-battle 0 votes 2 answers 256 views What is a better way to max out return? asked Sep 15, 2013 by pokemanfan3 return evs base-power 0 votes 1 answer 395 views How would you calculate the power of return on Slaking? asked Jul 25, 2013 by dashingdude return base-power moves 1 vote 1 answer 233 views Are these Pokemon returning? asked May 28, 2013 by gian94 return 0 votes 1 answer 3,788 views How much damage would Return inflict if the users happiness was 150-199? asked Mar 29, 2013 by ☆Frostily∞Froslass☆ return base-power happiness 0 votes 1 answer 610 views Charizard is returning: is it a rumor? asked Mar 8, 2013 by Enderdragon charizard return episodes 0 votes 1 answer 475 views Can Return get effect from Technician? asked Jan 29, 2013 by Flare technician return base-power 0 votes 2 answers 1,164 views What is return/frustration's max power? asked Dec 15, 2012 by Generekt base-power return happiness frustration 0 votes 1 answer 376 views How much happiness does a Pokemon have to have for Return to have a base power of 70? asked Dec 8, 2012 by Aura Warrior happiness return base-power 0 votes 1 answer 190 views Does friendship with Pokemon affect anything more apart from Return and Evolution? asked Nov 30, 2012 by Flare return 0 votes 1 answer 233 views How does the Base Power of Return change with the user's happiness? asked Nov 27, 2012 by the_netts return frustration happiness base-power 0 votes 1 answer 391 views Does the return or frustration animation change when the pokémon love or hate you more ? asked Oct 17, 2012 by DarkStar move-animation return frustration 2 votes 1 answer 3,845 views If my Umbreon evolved by happiness, is the move "Return" 's attack power 110? asked Mar 29, 2012 by SpikeyEaredPichu eevee soothe-bell umbreon return attack power Page: 1 2 next » Useful Meta Posts How to change your username How to add a user avatar Why was my post hidden? The points system Question etiquette Flags vs Downvotes Anime FAQ


text: I found the meal here to be above excellent. The chef and his niece went out of their way to ensure we had a good experience. The French are not noted for their love of hot spocy food, but the chef knowing we were english made sure thhe spices met our requirements to the letter. It was a pleasure... read more


text:
Five Children and It
From Library Staff
Chapter Book
While their parents are helping with the war, five siblings have been sent to the countryside and discover a magical creature with the ability to grant wishes.
From the critics
Community Activity
CommentAdd a Comment
Great premise, well told. Surprises and complications keep the story consistently entertaining. Worth reading by fans of British fantasy. The portrayal of Native Americans and other characters shows the limitations of Nesbit's time.
This book is so wonderful! I think it would be appropriate for any age because I appreciates all of Nesbit's snarky humour, but a child would appreciate the story on a whole. This would be an excellent book to read to your kids. It even comes with a secret hidden moral. So good.
AgeAdd Age Suitability
SummaryAdd a Summary
The last thing Cyril, Anthea, Robert, Jane, and their baby brother expect to find while digging in the sand is a Psammead?an ancient Sand-fairy! Having a Sand-fairy for a pet means having one wish granted each day. But the fivesome doesn?t realize all of the trouble that wishes can cause.
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Translate from English to German for Amazon Selling Listing
Closed - This job posting has been filled and work has been completed.
Job Description
Need someone who good at translation from English to German for our German Amazon Seller Store. We got about 300 listing at the moment and should have more later on. All the listing file is in a MS Excel format. It need to be translated back into the same format as MS Excel. We will pay 1USD per listing. First 150 listing need to be completed by mid of Sept, 2014


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Water supplies and drought outlooks are grim in most Western states.
Former Reclamation Commissioner Daniel Beard tells how defunct water policy, and the bureau itself, contribute to drought.
When a NASA scientist speaks in blunt terms about water supply, other scientists take notice.
Tension is rising between Mexico and the U.S. over the little water left in the drought-stricken Rio Grande.
In the drought-stricken West, water cops, singing governors and giant walking raindrops are just some of the odd measures spawned by water-conservation campaigns.
In "High and Dry: The Texas- New Mexico Struggle for the Pecos River," lawyer Emlen Hall considers the 1948 Pecos River Compact and how it failed to take into account the unpredictable nature of the river it sought to control.
Conservationists say it's time for another flood of the Colorado River through Glen Canyon Dam to restore beaches and habitat downstream in Grand Canyon National Park.
The agreement between state and federal agencies to keep a "minimum flow" of water in New Mexico's Rio Grande and Pecos Rivers has failed to do the job in this year's severe drought.
California's San Francisco Bay may become the site of the country's second-largest coastal wetland restoration project, if all goes according to plan.
Port of Portland officials and U.S. Army Corps of Engineers want to dredge the Columbia River, but a series of articles in The Oregonian reveals major flaws in the plan, resulting in a controversial exchange between dredgers and critics.
The Southern Ute Tribe is upset with Colorado state officials for issuing a permit to allow two coalbed-methane wells to spill polluted water into the Florida River, upstream from the tribe.
Activists continue to fight against dams on the Bear River, one of three sources that feed Utah's Great Salt Lake, in their push for stricter water conservation along the Wasatch Front.
The brine-shrimp industry of Great Salt Lake has helped put that misunderstood ecosystem under a microscope; can the lake be saved from its history of abuse and a rapidly increasing population around it?


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bhut powder
A love to add pepper powder to almost anything I eat. I dehydrate them in dehydrator then put them in a coffee grinder to make the into powder. Then just sprinkle on food like salt or pepper. Yummy! These are some bhut i just dehydrated and about to add to the jar.
I bought a reall nice one at wally world last year for about $30. I was tired of listening to my wife complain when she would go to grind up some coffee beans and make a pot of Bhut, Moca coffee. So, I said, fine, you keep the ten dollar grinder and I went and got a real nice one. Has settings for grind, drip, expresso, etc...
I have a question though, Do you grind up the whole pepper or just the skin. I usually grind up the skin, seeds, pulp and all.
I would Imagine putting them on a skewer and throwing them on the grill for a few minutes would intensify the flavour as well. hollow out Habaneross, stuff them with a scallop, warp in bacon and cook on grill. of course bhuts would be a little for for that.


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A method of inhibiting the proliferation of tumor cells is disclosed which comprises the treatment of such tumor cells with a benzodiazepine having a selective affinity to bind peripheral binding sites on the tumor cell in order to induce non-proliferation of said tumor cells.
1. A method for treating a patient afflicted with tumor cells having specific, saturable peripheral binding sites which comprises orally administering to the patient a benzodiazepine having a selective affinity to bind to the peripheral binding sites on the tumor cells, which cells are sensitive to treatment with the benzodiazepine, said benzodiazepine having the formula ##STR2## wherein R1 is C1 to C3 alkyl, C2 to C3 alkenyl or C2 to C3 alkynyl; Y is halogen, hydroxy or lower alkoxy; X is halogen and Z is halogen or hydrogen, in a daily dose between about 10 mg/kg of body weight of the patient and about 50 mg/kg of body weight of the patient which is effective for inhibiting the proliferation of said tumors cells.
2. The method of claim 1 wherein Y is halogen.
3. The method of claim 2 wherein X is halogen.
4. The method of claim 1 wherein R1 is methyl, ethyl, or allyl.
5. The method of claim 4 wherein Y is Cl or methoxy.
6. The method of claim 5 wherein Z is Cl.
7. The method of claim 1 wherein the benzodiazepine is selected from the group consisting of 7-chloro-5-(4-methoxyphenyl)-1-methyl-3H-1,4-benzodiazepine-(1H)-one; 7-chloro-5-(2,4-dichlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2(1H)-one; 7-chloro-5-(2,4-dichlorophenyl)-4,5-dihydro-1-methyl-3H-1,4-benzodiazepine-(1H)-one; 1-allyl-7-chloro-5-(p-chlorophenyl)-3H-1,4-benzodiazepine-(1H)-one; 7-chloro-1-ethyl-5-(p-chlorophenyl)-3H-1,4-benzodiazepine-(1H)-one; and 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepine-one
8. The method of claim 1 wherein the benzodiazepine selected is 1-allyl-7-chloro-5-(p-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one.
This application is a continuation of application Ser. No. 030,932, filed Mar. 26, 1987, now abandoned, which is a continuation of Ser. No. 655,653, filed Sept. 28, 1984, now abandoned, which is a continuation-in-part of Ser. No. 534,169, filed Aug. 17, 1983, now abandoned.
There is disclosed a method of inhibiting the proliferation of tumor cells which comprises treatment of such tumor cells with a benzodiazepine having a selective affinity to bind peripheral binding sites on the tumor cell, said tumor cell having specific, saturable, peripheral binding sites.
The benzodiazepines useful in the above method are ones having an affinity for the peripheral binding site on tumor cells having such a binding site. Further, an especially preferred class of benzodiazepines are those of the formula ##STR1## wherein R1 is C1 to C3 lower alkyl, C2 to C3 alkenyl or C2 to C3 alkynyl; Y is halogen, hydroxy or lower alkoxy; X is hydrogen or halogen and Z is hydrogen or halogen.
The compounds of formula I are preferred since they exhibit a selective affinity for the peripheral binding sites on tumor cells.
The specific binding of benzodiazepines has been observed in many tissues and cell types and can be pharmacologically separated into two classes. The first class is represented by binding of the central-type receptors of the brain whcih are thought to mediate the known pharmacological effects of the benzodiazepines. The other calss of receptor is represented by the peripheral-type binding site found on a variety of tissues and cell, for example, kidney, heart, platelets, mast cells, lymphocytes and many cell lines.
Clarke and Ryan, Nature, 287, 160-161 (1980) have reported that some benzodiazepines inhibit proliferation of Swiss 3T3 cells in culture and further induce the differentiation of Friend erythroleukemia cells. Most of the compounds utilized in their study, however, were selective for central-type receptors displaying ED50 values substantially greater than 100 μM. The two most active compounds reported by Clarke and Ryan exhibited substantial binding to both peripheral and central receptor sites (not reported by Clarke and Ryan), the most active being diazepam with an ED50 of about 30 μM. The study, however, did not determine benzodiazepine binding constants and, therefore, stated that no correlation could be made between such constants and the antiproliferative effects seen. The article did ascribe the activity of the compounds to their lipophilic nature. Further, Matthew et al. Proc. Natl. Acad. Sci. USA, 78, p.p. 3935-3939, June 1981 have reported the use of various benzodiazepines to induce melanogenic differentiation in B16/C3 melanoma cells.
Applicants have found, however, that a correlation does exist between various benzodiazepines' binding affinities for peripheral receptors and their antiproliferative activity on tumor cells. Further it has been found that some of these compounds induce terminal differentiation of the tumor cells to the normal state but that the compound's ability to induce differentiation is not correlated to their relative affinity to bind to the peripheral site and thus the ability to cause differentiation is a separate function not associated with the benzodiazepines' ability to inhibit proliferation of tumor cells.
The antiproliferative effect is paralleled by the ability of the benzodiazepines to inhibit the incorporation of thymidine in the most studied system, i.e. thymoma cells. Thus by measuring levels of tritiated thymidine in the cell system a correlation can be made between thymidine uptake and antiproliferative activity on tumor cells.
Further differentiation of the tumor cells to the normal state is measured by the ability of the cell studied to make hemoglobin, i.e. to function as a normal blood cell.
The preferred class of benzodiazepenes are ones which are known in the art along with methods to produce same. Examples of such prior art teaching include for example, U.S. Pat. No. 3,336,295. This patent is incorporated by reference herein in so far as it will enable one skilled in the art to make these known compounds.
The benzodiazapines utilized in the present method may be administered by a variety of routes, most preferably by oral means. Another method which is useful entails treatment of marrow cells in vitro followed by transplantation of the cells in the host. Such methods are known in the art or may be modified by one skilled in the art in the present circumstances, see, for example, Sarna et al., Cancer Treatment Reports, 66, No. 2, February 1982 or Appelhaum et al., Journal of Clinical Oncology, 1, No. 7, July 1983. An effective dose of the preferred benzodiazapines may range from about 10 mg/kg to about 50 mg/kg per day but may be adjusted to higher doses if necessary given the patient's condition, body weight and responsiveness to treatment.
Thymoma cells, AKR mouse thymoma line, BW 5184.108.40.206.Ouar.1.(Cell Distribution Center, Salk Institute, San Diego, Calif.), were grown in Iscove's Modified Dulbecco's Medium (IMDM) containing 5 percent fetal calf serum, collected by centrifugation at 100�g and washed in Balanced Glucose Salt (BGS) buffer, the composition of which is: KCl, 5.0 mM; NaCl, 120.0 mM; Na2 HPO4, 5.0 mM; Tris, 5.0 mM; CaCl2, 0.6 mM; MgSO4, 1.0 mM and glucose, 5.5 mM with a final pH of 7.4. Incubation and binding of tritiated 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one to thymoma cells was carried out in BGS buffer at 0� C. for 40 minutes with the indicated concentrations of labeled ligand. To assay the binding, the rapid filtration method was utilized as outlined in the article of Taniguchi et al., Life Science, 27, 171-178 (1980) and 10 μM of unlabeled diazepam was used as the competitive inhibitor of binding to determine the nonspecific binding. A Saturation and Scratchard plot of the binding data using least square fit to define the regression line (r=0.97) was utilized (FIG. 1 and Insert). Analysis of the saturation plot showed a single class of binding sites with a KD of 4.4�1.1 nM (mean�s.e., n=5) and the maximum amount of ligand bound (Bmax) was 477�98 fmoles per 106 cells (mean�s.e., n=5). That a peripheral binding site on the thymoma cells is involved was demonstrated by the ability of the unlabeled 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one at 200 nM to completely inhibit the binding of tritiated diazepam, a ligand which binds both peripheral and central sites whereas clonazepam, a central site selective benzodiazepine, did not inhibit diazepam binding even at 10 μM final concentration.
The binding of the tritiated 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one to the thymoma cells reached a plateau after 30 minutes of incubation at 0� C. and dissociated with a t1/2 of 17 minutes when an excess (10 μM) of unlabeled diazepam was added to the incubation.
The following benzodiazepines were tested in a dose-response relationship for (A) inhibiting tritiated thymidine incorporation by thymoma cells and (B) inhibiting tritiated 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one binding to thymoma cells (FIGS. 2 and 3). The compounds and symbols utilized in the figures were:
1. 1-allyl-7-chloro-5-(p-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one (�);
2. 7-chloro-5-(4-methoxyphenyl)-1-methyl-3H-1,4-benzodiazepin-2(1H)-one (�);
3. 5-(4-chlorophenyl)-7-fluoro-1-methyl-3H-1,4-benzodiazepin-2(1H)-one (□);
4. diazepam () and
5. 1-methyl-5-(4-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one ().
(A) For the tritiated thymidine assay, cells were seeded in 96-well tissue culture clusters (Coster Co.) at 1�105 cells per well for the 22 hour assay or 1�104 cells per well for the 44 hour assay. The benzodiazepines were diluted from ethanol stock solutions into Iscove's Modified Dulbecco's Medium and then directly into the wells to yield the appropriate final concentration in a total volume of 200 ul. The ethanol concentration was never higher than 0.4 percent and controls containing the appropriate ethanol concentrations were included in the experiments to show that ethanol at those concentrations had no effect on proliferation of the thymoma cells. After either 22 hours or 44 hours of incubation at 37� C., the cells were pulsed for 2 hours with 1 μCi/250 μl of tritiated thymidine and 0.5 μM of unlabeled thymidine. Cells were then harvested and washed over glass fiber filters by a Microharvester� (Bellco Glass, Inc.). The filters were dried and placed in 4 ml of Aquasol (New England Nuclear) in minivials for scintillation counting. Control counts were expressed as 100 percent and all other counts as percent of control. ED50 was calculated as the dose required to reduce the tritiated thymidine uptake to 50 percent of control. The results are plotted in FIG. 2.
(B) Binding assays were performed as in Example 1. Thymoma cells were incubated with tritiated 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one (0.8 nM) with or without various concentrations of the five benzodiazepines of Part (A), Example 2, in Balanced Glucose Salt buffer at 0� C. for 40 minutes. Control binding was defined as specific binding in the absence of any unlabeled benzodiazepines and was expressed as 100 percent. The IC50 was calculated as the dose of benzodiazepine which inhibited tritiated 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one binding by half.
The following benzodiazepines were tested for a correlation between their binding constants and their ED50 in inhibiting tritiated thymidine uptake by thymoma cells. The binding constants (IC50) and ED50 in inhibiting tritiated thymidine uptake were determined following the procedures of Example 2. Values for the compounds are plotted in FIG. 4, each value being the mean of at least four experiments. The benzodiazepines tested and related numbers in FIG. 4 (in parentheses) were as follows:
1. Diazepam (12)
2. 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one(5)
3. 1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one(8)
4. 5-(2-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2(1H)-one(7)
5. 5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2(1H)-one(11)
6. 1-methyl-5-(4-fluorophenyl-3H-1,4-benzodiazepin-2(1H)-one(9)
7. 5-(4-chlorophenyl)-4,5-dihydro-7-fluoro-1,4-dimethyl-3H-1,4-benzodiazepin-2(1H)-one(10)
8. 5-(4-chlorophenyl)-7-fluoro-1-methyl-3H-1,4-benzodiazepin-2(1H)-one(4)
9. 7-chloro-5-(4-methoxyphenyl)-1-methyl-3H-1,4-benzodiazepin-2(1H)-one(14)
10. 7-chloro-5-(2,4-dichlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2(1H)-one(3)
11. 7-chloro-5-(2,4-dichlorophenyl)-4,5-dihydro-1-methyl-3H-1,4-benzodiazepin-2(1H)-one(13)
12. 1-allyl-7-chloro-5-(p-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one(15)
13. 7-chloro-1-ethyl-5-(p-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one(1)
14. 7-chloro-5-(2,6-dichlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one(6)
15. 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one(2)
The plot in FIG. 4 utilizes the numbers assigned above for the respective benzodiazepines.
The IC50 values spanned about two orders of magnitude, ranging from 6 nM to 1 μM. When the compounds were included in the thymoma cell culture at μM concentrations, they dramatically reduced the cell number during subsequent days of culture without being cytotoxic (as determined by trypan blue staining). The thymidine uptake inhibitory effect appeared after 8 hours (roughly the doubling time of the cells) of incubation and was marked after 22 hours. The inhibition was reversible by diluting the cells into fresh medium which contained no benzodiazepines. All of the benzodiazepines inhibited tritiated thymidine incorporation in a dose dependent manner (FIG. 3), the half effective concentrations (ED50) required ranged from 6 μM to 180 μM. These values were ranked with the IC50 values of binding and plotted on log-log scale (FIG. 4) resulting in a positive and highly significant correlation with the coefficient of correlation being r=0.85 (p<0.001).
A DS 19 Friend erythroleukemia cell line (FEL) was utilized as the model for studying the effects of various benzodiazepines on cellular differentiation. The Friend lines were derived from mouse (DBA/2) spleen cells infected by the Friend virus complex. The FEL cells are a widely used model system for studying differentiation. To assess the differentiation of FEL cells the induction of synthesis of hemoglobin was used as the marker to demonstrate terminal differentiation. The protocol utilized consisted of the benzidine staining method. Cells were seeded at 1�104 ml and incubated with inducers in Coster Culture Clusters (24 cells) for 5 days. On the 5th day, two hundred (200) μl aliquots of cells were mixed with 100 μl of 0.2% benzidine dihydrochloride in 0.5N acetic acid with 1% of 30% H2 O2. Cells that stained blue were scored in a hemacytometer as a % of total cell number.
Of twenty five (25) of the benzodiazepines tested it was observed that sixteen induced differentiation (weakly to strongly active) in a concentration-dependent manner. The concentration of each compound required to induce 50%, 20% or 10% of the FEL cells along with the half-maximal concentrations for each compound required to inhibit 50% of the binding of 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepine-2-one to the FEL cells (IC50) is listed in the following table:
TABLE______________________________________ Compound ED50 (μM) IC50 (nM)______________________________________1. (+)-5-(2-fluorophenyl)-1,3-dihydro- 9 1097 1,3-dimethyl-7-nitro-2H--1, 4-benzodiazepin-2-one2. 7-chloro-1,3-dihydro-5-(4- 20 100 hydroxyphenyl)-1-methyl-2H--1,4- benzodiazepin-2-one3. 7-chloro-5-(4-methoxyphenyl)-1- 33 15 methyl-3H--1,4-benzodiazepin- 2-one4. diazepam 55 795. 7-chloro-1,3-dihydro-3- 80 236 hydroxy-1-methyl-5-phenyl- 2H--1,4-benzodiazepin-2-one6. 1,3-dihydro-1-methyl-5- 80 704 phenyl-2H--1,4-benzodiazepin- 2-one______________________________________ Compound ED20 (μM) IC50 (nM)______________________________________7. 5-(4-chlorophenyl)-7-fluoro- 34 13 1-methyl-3H--1,4-benzodiazepin- 2(1H)--one8. 5-(4-chlorophenyl)-1- 30 54 methyl-3H--1,4-benzodiazepin- 2(1H)--one9. (-)-5-(2-fluorophenyl)- 86 1037 1,3-dihydro-1,3-dimethyl-7- nitro-2H--1,4-benzodiazepin-2-one10. 7-chloro-5-(4-chlorophenyl)- 28 6 1,3-dihydro-1-methyl-2H-- 1,4-benzodiazepin-2-one11. 7-chloro-5-(4-chlorophenyl)- 45 20 3-hydroxy-1,3-dihydro-1- methyl-2H--1,4-benzodiazepin- 2-one12. 1-methyl-5-(4-fluorophenyl)- 100 327 3H--1,4-benzodiazepin- 2(1H)--one______________________________________ Compound ED10 (μM) IC50 (μM)______________________________________13. 5-(2-fluorophenyl)-1,3- 32 80 dihydro-1-methyl-7-nitro- 2H--1,4-benzodiazepin-2-one14. 5-(4-chlorophenyl)-1-methyl- 60 34 7-nitro-3H--1,4-benzodiazepin- 2(1H)--one15. 5-(2-chlorophenyl)-1-methyl- 60 175 3H--1,4-benzodiazepin-2(1H)-- one16. 7-chloro-5-(2-chlorophenyl)- 60 11 1,3-dihydro-1-methyl-2H--1, 4-benzodiazepin-2-one______________________________________
All of the benzodiazepines active in inducing differentiation bind to the peripheral-type benzodiazepine sites with affinities that ranged from 6 nM to 1 μM but there was no obvious correlation between the binding constants and the concentrations needed to induce differentiation. Indeed the two phenomena of induction of differentiation and binding to the peripheral-type benzodiazepine sites could be dissociated by the stereoisomers nature of the former and lack of stereospecificity of the latter. The two stereisomers set forth in Table 1 with an optical chiral center at the methyl substitute 3-position (Compounds 1 and 9) exhibited equivalent IC50 's of about 1 μM whereas the (+)S isomer was the most potent inducer tested (ED50 =9 μM) and the (-)R isomer was classified as moderately active (ED20 =86 μM).
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by Brandon Wise | CBSSports.com
"Every outing I've given up a home run," said Norris, who has allowed five homers in four official spring starts. "But you are trying to work on things, trying to get comfortable out there. We had a great year last year and [now we're] just trying to get the ball rolling again. Different beast, obviously in the regular season and postseason."
Manager Buck Showalter noted his command has been off.
"Command has not been very good, as good as he's capable of," Showalter said. "He's an athletic guy, can throw it where he wants to most of the time. He hasn't been very consistent with that yet. He's crisp with most things, just not [with the] consistency of command."
by Brandon Wise | CBSSports.com
"We wanted (Baker) to go long," manager Joe Girardi said. "I called him in before that (last) inning and I said, 'We're going to wait, because we don't want you to go just an inning or a half an inning and all of a sudden it starts pouring and they call the game.' So he'll start tomorrow."
by Brandon Wise | CBSSports.com
Pineda, who has a 1.32 ERA so far this spring, did not allow more than a single to any hitter in his appearance.
by Shawn Krest | CBSSports.com
Storen had surgery on his left, non-throwing, hand to remove a hook on the hamate bone. He has been throwing bullpens and making minor league appearances to prepare for the game back, per Jamal Collier of MLB.com.
Storen pitched one inning, allowing one hit and one walk.
by Shawn Krest | CBSSports.com
Span had a procedure to fix a small tear in his right abdomen.
Span was able to swing a fungo bat in the batting cage, per MLB.com's Jamal Collier.
"It's good progress," manager Matt Williams said. "It's part of the rehab progression. Of course, yeah, we want him back as quickly as possible, keeping in mind that he's just coming off of surgery. So any time you have to go in there, you have to take time to get well again. But yeah, it's encouraging."
by Shawn Krest | CBSSports.com
Rendon still hopes to be ready for Opening Day.
by Shawn Krest | CBSSports.com
Betts' first homer of the spring was an inside-the-parker in his first game back. On Friday, he hit one the old fashioned way, lining a 1-1 pitch over the wall in left center for a two-run homer.
Betts was two for three on the day and improved his spring average to .487.
by Igor Mello | CBSSports.com
"He has a skill set that can help you win games," Banister said. "If he makes this club and stays with this club, he adds value in winning situations.
"Given the construction of the core guys on our roster, he's unique" Banister said. "I'd hate for us to have a double late in the game and not be able to score from first on the play. I think he has the potential to be a contributor, but there is a ways to go to finalize the roster."
DeShields would be sent back to the Astros if he is not on the Rangers' opening day roster.
by Michael Hurcomb | CBSSports.com
The Braves did most of their damage against Buchholz during a three-run second inning. Kelly Johnson added a solo home run off Buchholz leading off the sixth inning, which chased the right-hander from the game.
His ERA went from 1.80 to 3.60 in his fourth spring start. Buchholz has allowed eight runs (six earned) in his last two starts.
by Igor Mello | CBSSports.com


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How do I...
How to make dough without butter
Ingredients for 4 people
1.5 lb. soft wheat flour
½ lb. high gluten Canadian flour
¾ oz. yeast
1 pinch salt
2 tbsp. oil
3 ½ tbsp. warm water
Mix together the flours, then place them on a flat work surface or wooden cutting board and form a well.
Place the yeast in a bowl of warm water, stir and let dissolve for a minute.
Gradually pour the water and yeast into the center of the well and begin mixing it into the flour using a fork.
Do not let it escape from the center of the well. Add the oil and then the salt. Using a dough scraper, collect the any remaining flour.
Then, begin to knead the dough stretching it out, then folding it over. Continue to knead the dough until smooth. If it is too dry, add a little water. If it becomes to wet, add a little flour.
Once you are done kneading the dough, cover it with a damp cloth. This allows for air to pass back and forth without drying out the dough.
Let the dough rest until it has doubled in volume. To check to see if the dough has finished rising, press it with your fingertip and if the fingerprint disappears, it is ready to be cooked.
Now you can use the dough to prepare pasta, bread or pizza.
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As Stefan would say, this place has EVERYTHING! This 1/1 duplex apt is oh so close to Mopac (no, really!) & Windsor. It has a mid-cent. modern vibe, int. brick walls, cool furniture, ALL up-to-date, 2 TVs w/ cable, wifi, cool patio, 3 mins to dtown.
Space where guests can cook their own meals
Towels, bed sheets, soap, and toilet paper
Space where guests can cook their own meals
Towels, bed sheets, soap, and toilet paper
Central heating or a heater in the listing
In the building, free or for a fee
In the building, free or for a fee
Continuous access in the listing
Breakfast is provided.
The listing can accommodate a gathering of 25 or more attendees
Easy access to the building and listing for guests in wheelchairs
Private or Shared
Free, in the building or nearby
Posted emergency information and resources
The Space
This place has one queen bed and a sofa. So, it officially sleeps 2, but a third person could always rough it on the sofa. It has painted interior brick walls, mid-century modern construction, cool furniture, lofted ceilings, and nonstop style--all tucked into a super central location!
Although the layout makes the Suite Sweet feel quite spacious, at 500 square feet it is very efficient. It is heated and cooled through window and portable units.
Guest Access
Wifi, cable TV, stackable W/D, microwave, free onsite parking, dishwasher, disposal, and being within minutes of everything.
Combo deadbolt makes access a breeze! No fumbling around with keys.
Interaction with Guests
The Sweet Central Suite is the "B" side of a duplex. (Deluxe Digs is the "A" side and is also on AirBNB.) I live off site, so we won't be hanging out together.
The Neighborhood
This property is located on a street that is as close as you can get to Mopac, running parallel with it. This street features smaller homes built in the 1950s, but one street over (in the other direction) is one of the most desirable neighborhoods in Austin, featuring beautiful, stately, older homes. Great neighborhood for walking and running. Three minutes (by car) from Clarksville and West Austin restaurants like Jeffrey's, Josephine House, Cippolinas, and Wink, and coffee shops like Cafe Medicci's. Flagship Whole Foods Market is 5 minutes away.
1. No smoking.
2. No pets.
3. It's a duplex, so be considerate of the guests in the "A" side.
4. Have fun.
5. Be nice.
We loved our stay at Christina's casa. It's located off 24th street, so it's within easy striking distance of the UT campus and downtown. The duplex is super clean, well designed, and comes with a washer and dryer. We would definitely stay again.
We loved staying at Christina's! A lovely space, comfy bed and great shower. Christina communicated well with us and always very quickly.
We had been in town for SXSW and having stayed in a bland hotel for part of the stay it was a relief to stay in this cozy space.
The neighborhood is quiet and we slept well, barely noticing the nearby MOPAC.
Being without a car it was only $10 in a cab downtown and the cabs found us easily.
Thanks Christina, we would highly recommend and definitely stay again if we're in Austin :)
I rented this apartment for my parents who came to visit for over three weeks. Overall, it was a positive experience. The apartment looked just like on the photos, clean and stylish. Christine was a responsive host, answered several of my questions ahead of time and over the first few days of my parents' stay, until they got completely settled.
She also reacted quickly when a couple of days into their stay, my parents discovered a mess left by a previous tenant that the cleaners didn't catch. We talked about the issue within an hour, found a quick fix and then Christine came by the following day to make sure everything was clean.
The neighborhood around the apartment is very nice, with quiet walkable streets. There's a grocery store and a couple of neighborhood restaurants and shops within a 20-minute stroll. Everything else is within a short drive away - downtown, more shopping, etc. The only issue is that the duplex where the apartment is located sits right next to a highway that also has train tracks and the highway is currently undergoing improvement, so there's construction vehicles, noise and mud/dust in close proximity. There's nothing the host can do about this and we knew all this before we booked, because in our case it was important that my parents stayed closer to the neighborhood where we live. I am taking off a star because my parents said it was pretty noisy at night, they could hear the road and the trains, but, thankfully, no construction noise (I think all work takes plays during the day). Again, not the host's fault, and may not be an issue for everyone.
All in all, the apartment had everything my parents needed, it was comfortable, stayed warm on cold days in late Feb-early March and everything in it worked (Wi-Fi, plumbing, heater, etc). Thanks!
The good news: They are building a sound wall between the highway/train tracks and the property that will greatly reduce if not eliminate the noise.
The bad news: It's not done yet, and construction causes noise and dust. [Insert joke here about the price of progress or a "One step forward..." quip.]
In the meantime, I'm equipping the property with a white noise machine from Brookstone. Thank you for the feedback!
Sweet Central Suite was clean and charming, very well-furnished and in an excellent location. Christina is very easy to deal with and a very responsive communicator.
The location of the duplex is good. It's in an old upscale neighborhood just a 10 minute drive from downtown. The apartment was very clean and we had some amenities we didn't expect like laundry detergent and bath soap. There were plenty of cookware for making meals and we were able to relax and enjoy our time in Austin. The only small complaint is the duplex is right on the freeway and train tracks. A train rolls through every couple hours throughout the night. After the first couple nights it doesn't bother you anymore. I was actually surprised how dampened the noise was. It could have been much worse. I sure wouldn't hesitate booking this apartment again. It was perfect for my wife, infant daughter and myself.
We have stayed at Sweet Central Suite many times before and it is always neat, clean, quiet and well furnished. Christina is an awesome host.
What a wonderful first experience on AirBnb! Christina was very helpful and always replied to emails within 24 hours. Sweet Central Suite was lovely -- the place was immaculate when we got there. It was the perfect sized place for me and my boyfriend to stay. Very conveniently located, with downtown just minutes away. Yes, you could see Mopac from the front door, however, like everyone else has said, you can barely notice the sounds. Overall, it was a great stay and I would definitely come back.
This host has 41 reviews for other properties.View Other Reviews
I'm a proud native Austinite and an even prouder mother of two. I think it's the combination of those two things that makes me love being an AirBNB host in ATX as much as I do! When I'm not cleaning and prepping Sweet Central Suite for you, dear guest, I enjoy running around Lady Bird Lake, movies at Violet Crown Cinema, and/or eating at El Alma. And I highly recommend any and all of these things to you during your stay!


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Is The Way Forward Really Ford's Way Forward? Sameer Kirtane Rachit Shukla Louis Wang Jimmy Zhan Overview • Ford's current status • Industry Analysis • Recent History • What is the Way Forward? – Operations, Infrastructure and Human Resources – Marketing and Sales – Technology Development • Recommendations Current Status • Leadership change • Market share ↓ since 2000 from 23.7% to 15.5% in N.A. • Reported loss of $1.2B qtr ending Sept. 2006 • On its way to losing $8-9B in 2006 alone • Third restructuring effort: Way Forward Alan Mulally Source: http://media.ford.com Recent History • Ambiguous business-level strategy in last decade – Neither successful differentiator nor cost-leader • Lacked innovation in compact and mid-sized cars • Focus on SUV division and luxury portfolio • Rising gas prices – Consumers fled SUV and luxury portfolio → Strategic Failure • Costs grew disproportionately to rivals – Estimate: Costs Ford $2500/vehicle more to produce than Foreign rivals Industry Analysis • N.A. Automotive Industry: Difficult to be in – Positives • Captive but essential suppliers • High capital costs of potential entrants • Lack of feasible substitutes – Negatives • Low switching cost of buyers between firms • Fierce internal rivalry due to manufacturers competing with extensive product lines Porter's Five Forces Model What is the Way Forward? Operations Infrastructure Human Res. Way Forward Technology Marketing and Sales Development Areas of Improvement Operations, Infrastructure, and HR • Reducing idle or non-profitable plants – Closure of 9 Plants and 7 Assembly Plants by 2012 • ~35% reduction in manufacturing jobs – Reduce hourly headcount by 25- 30K and salaried headcount by 14K by 2008 • Target $5B reduction in costs by 2008 → Savings of approx. $1552/vehicle in N.A. • However GM's fixed cost per vehicle is $2354 lower than Ford's – Further reductions in fixed costs Cost Analysis needed to reach parity Marketing and Sales • Currently lack of differentiation between Ford, Lincoln and Mercury results in cannibalization of each other's sales • Refocus on consumer through repositioning of brands – Purchases driven by "perceived" value derived from brand reputation and reflection of personality and lifestyle – Create an image around brand and give consumers unique reason to buy the brand vs. rivals • Ford positioned to target active, hardworking individuals • Lincoln aimed at Americans living the American dream – Leverage strong following of F-150 and Mustang to impart the Ford spirit Technology Development • Introduction of innovative products and new development methods to sustain recovery – Fresh product lineup → 70% of vehicles (by volume) new or significantly upgraded – Hybrid and alternative energy technologies • Introduce hybrid options in existing product lines • Major investments in flexible-fuel, diesel and hydrogen powertrains – Redesign vehicles with new 6-speed transmission to improve mileage • Leverage global infrastructure to pool design resources – Sharing "B" and "C" small car chassis used abroad – Leads to decreased costs and capturing efficiencies of scale Recommendations • Adopting a clear differentiation strategy and supporting value-chain activities should improve Ford's N.A. position • Achieve cost parity – Continue cost cutting beyond those already specified in the plan – Focus on reduction of manufacturing costs – Additionally cut $3.2B in cost to achieve parity with Foreign rivals and $2.7B to achieve parity with GM – To compete globally with GM → $11B in overhead needs to be reduced • Invest in unique advertising to promote differentiation strategy • Create uniquely designed vehicles with shared platforms and technologies IS THE WAY FORWARD REALLY FORD'S WAY FORWARD? Sameer Kirtane, Rachit Shukla, Louis Wang, Jimmy Zhan November 17th, 2006 Introduction Ford's market share in the United States has fallen from 23.7% in year 2000 1 to 15.5% in 2 2006 . Despite changes in Ford's leadership, the company reported a loss of $1.2 billion over all its global operations in its most recent quarter ending in September of 2006, setting the company on its way to losing $8 to $9 billion this year alone 3 . Its dismal performance has prompted Ford to launch, in January 2006, its third restructuring effort of the past five years 4 , the Way Forward. The Way Forward is a broad initiative to address the competitiveness of its North American operations in the Ford, Lincoln, and Mercury product lines. On the heels of a $2 billion loss from the North American division in FY 2006 Q3, the Way Forward Plan has been modified and moved to an accelerated schedule. The aim is to return the North America division to profitability by 2009. In this paper, we will be discussing the efficacy of the accelerated restructuring effort in improving Ford's competitive position vis-à-vis business level strategies. The aspects of the Way Forward we will be focusing on are the substantial reduction of manufacturing costs, the emphasis on the customer, and the introduction of innovative products and development methods a . Industry However, to understand Ford's position today requires understanding the North American automotive industry, defined as manufacturers of cars sold in North America. Porter's Five Forces (Appendix B) shows that the industry has captive but essential suppliers, high capital costs for potential entrants, and a lack of feasible substitutes for the American commute. However, these positives are greatly outweighed by the low switching cost of buyers between firms in the industry and fierce internal rivalry, with many manufacturers competing with extensive product lines. As a whole, it is a difficult industry to be in. Ford's Recent History This intense internal rivalry suggests that to earn profits, a company must be uniquely better than its rivals, and the way to achieve this is through coherent business-level strategies. A clear business-level strategy will help a firm maximize margins and capture market share, both key given the stagnant market size of the industry. In the last decade, Ford's business strategy has become unclear, neither being a successful differentiator nor a cost leader. The company stopped innovating on many of its products, especially its compact and mid-sized vehicles, and instead focused attention on its truck and SUV divisions 5 and the expansion of its luxury portfolio (Premier Auto Group) via purchases of high-end brands like Land Rover and Volvo4. While one may argue that the luxury or truck strategy constitutes focus, this is an incorrect assessment given the large percentage of sales that are obtained through its other core automotive operations b . In fact, with rising gas prices, Ford's luxury and truck strategy has all but failed as consumers have fled its high gas consumption vehicles despite substantial price discounts 6 and have switched to its competitors, especially the Japanese automakers. Over this same time period, Ford's costs continued to grow disproportionately to rivals. Currently, it is estimated that foreign automakers may be able to produce cars at a cost of $2500 less per vehicle than Ford due a The entire accelerated Way Forward plan can be found in Appendix A b See Appendix E: 62% of sales by volume in the US come from trucks, 38% from traditional sedans, etc. to lower overhead costs from wages, pensions, and benefits5. Thus, the question arises: Will the accelerated Way Forward be a successful business level strategy? The Way Forward: A Real Business-Level Strategy We believe that the Way Forward will improve Ford's competitiveness within the industry by establishing a successful differentiation strategy. However, the full benefit of this strategy cannot be realized without achieving cost parity relative to its peers. We believe Ford's cost reductions will fall short on this parity front, hindering its overall turnaround effort. Analysis of the Way Forward's effect on Porter's value chain strongly suggests this conclusion. Operations, Infrastructure, and Human Resources c To become more cost efficient, the accelerated Way Forward plan calls for 16 plant closures, of which 7 are assembly plants, by the year 2012 (infrastructure and operations reduction). Additionally, the company is offering generous buyout packages to all United Auto Worker members to reduce hourly headcount by 25,000 to 30,000 and salaried headcount by 14,000 by 2008 totaling a ~35% reduction in manufacturing jobs (HR and operations). Ford's near term target is a $5 billion dollar reduction of North American operating costs by 2008 7 . Understandably, these attempts at cost reduction are rather severe and seem to fit the model of cost leadership, but the numbers are deceiving because Ford's cost structure is severely bloated. For example, Appendix C shows that under last year's sales figures, a $5 billion dollar reduction in costs would result in savings of approximately $1522 per car produced in North America. These cost savings, however, do not go far enough to achieve even cost parity with its traditional competitor, GM. On a global basis, GM's fixed cost per vehicle is $2354 less than Ford's 8 even though GM produced 34% more cars than Ford did in 2005 worldwide. Thus, further reductions in fixed costs by Ford seem necessary to just achieve industry parity. Marketing and Sales The second part of Ford's plan is to refocus on the consumer through repositioning of its brands and product mix to be more consistent with customer preferences. Currently, Ford lacks product differentiation between the three brands sold by the North American division – Ford, Lincoln, and Mercury. As a result, the divisions are cannibalizing each other's sales. As a Merrill Lynch analyst remarked: "[Mercury and Lincoln] are mostly dressed-up versions of mass-market Fords."5 The Way Forward attempts to address these issues by carefully focusing the company's brands on target segments (see Appendix D). For example, the Ford brand will be positioned to target active, hardworking individuals while the Lincoln segment will be aimed at Americans living the American dream. The difference between this new segmentation versus the original low-end (Ford), mid-end (Mercury), and high-end (Lincoln) segmentation is that Ford has now created a personality for their brands. By creating an image around the brand, they will give customers within each segment a unique reason to buy the brand versus rivals, allowing Ford to increase its margins and create perceived switching costs. This differentiation strategy is essential in the crowded automotive industry, where every company essentially sells cars with c Please note for clarity's sake, parts of Porter's value chain have been grouped together the same utility value within model type d . Customers instead purchase automobiles based on "perceived" value, often a function of brand reputation and how well that brand and model reflect their personalities and lifestyles. In addition to differentiating its three North American brands, the Way Forward stipulates that Ford should emphasize development and production of several car models that presently enjoy strong reputations, including the Ford F-150 and the Ford Mustang. These two models are a position of strength for the company, with high brand loyalty among buyers. They are often used as a symbol of the Ford name and its personality, and thus their continued success will enhance the company image as a whole, again supporting a strong differentiation strategy. Technology Development The final key piece of Ford's restructuring plan is the introduction of innovative products and new development methods. As Rich Wagoner (General Motors CEO) has said in Time Magazine, "No automotive turnaround has been successful without a steady flow of strong products." 9 Thus, the company will need a fresh product lineup to sustain its recovery. The Way Forward takes advantage of Ford's large R&D budget relative to its competitors8 by introducing new models, for example the new 7-passenger full size crossover vehicle. 10 Furthermore, Ford's Way Forward emphasizes the company's hybrid and alternative energy technologies and focuses on the growing popularity of hybrid vehicles. Way Forward's concentration in this category should help the company close the technological gap between Ford and its Japanese rivals while leaving the other American automakers behind. Additionally, the company plans to redesign many of its existing vehicles by incorporating new technologies such as a 6-speed transmission.10 In all, by 2008, 70% of vehicles by volume should be new or significantly upgraded according to Ford's Way Forward plan. Finally, the company hopes to leverage its global infrastructure to reduce product design times by pooling design resources and technological innovations while reducing costs by sharing car parts and car ideas.5 For example, they plan on introducing their "B" and "C" small car chassis used abroad.10 This is an example of leveraging their overseas technical expertise in certain car categories leading to better, more differentiated products while sharing components to decrease costs and to capture efficiencies of scale. Conclusion The Way Forward will, if executed properly, significantly improve Ford's North American position in the industry by adopting a clear differentiation strategy and value-chain activities that support it. However, to achieve success in the marketplace with such a strategy, Ford must also achieve cost parity. Thus, we recommend that Ford, in order to achieve cost parity, further continue its cost cutting beyond those already specified by the Way Forward, something the new management hints may happen in the near future. As shown in Appendix F, we estimate that Ford must cut, in North American operations, approximately $3.2 billion in fixed costs to achieve parity with foreign automakers and $2.7 billion to achieve parity with GM. Globally, to achieve cost parity with GM requires Ford to make an additional $11 billion in cuts in worldwide overhead. In addition, Ford should take care only to reduce manufacturing costs, not costs associated with differentiating the brand (R&D, Marketing, etc). By reducing non- d I.e. every brand's sedan will accomplish moving the owner from point A to point B comfortably and every light pickup truck will haul the same load weight. manufacturing costs, Ford risks cutting exactly those resources that are needed in successfully executing its new strategy. Moreover, Ford should invest immediately in unique advertising campaigns in order to ensure the aspects of differentiation are realized by the consumer, especially upon introduction of its new vehicles. Finally, for Ford to successfully reposition its brands, Ford must make sure to uniquely design each of its vehicle's external bodies to maintain differentiation while still sharing internal components to maximize synergies. Together with these recommendations and successful execution, Ford should be able to return to a competitive position in the marketplace and stabilize if not improve its market share and financial position. References and Sources 1 Ford Motor Company, Sustainability Report 2004/05, http://www.ford.com/en/company/about/sustainability/report/proData.htm; 2 Ford Q3 2006 Earnings Call Transcript, 10/23/06, SeekingAlpha, http://seekingalpha.com/article/19023 3 Ford: $6B auto loss looms, The Detroit News, 9/14/06, http://www.detnews.com/apps/pbcs.dll/article?AID=/20060914/AUTO01/609140365 4 BusinessWeek, David Kiley & David Welch, Oct 2, 2006, "Does Ford Deserve All the Street's Heat?" Iss. 4003, pg. 36 5 Time, Daren Fonda, Sept 18th, 2006, "Ford: Just Fix the Car", Vol. 168, Iss. 12; pg. 46 6 Newsweek, Keith Naughton, Sept 11, 2006, "Q & A 'We Understand We're in Trouble'; Bill Ford Jr. CEO, Ford" 7 Numbers from Ford Corporate Press Release and Conference Call, Sept 2006 and JP Morgan Analyst Research "Ford Motor Company –A Look at the Accelerated Way Forward Plan," September 18, 2006. 8 Deutsche Bank "Can Ford be fixed? First impressions of Alan Mulally" October 24th, 2006 9 Forbes Global, "Bill Ford's Next Act," June 23rd, 2003 10 Ford Press Release, "Ford Accelerates Way Ford," Sept 15, 2006 Appendix A: The Accelerated Way Forward Plan Taken from Sept. 15, 2006 Ford Press Release Titled "Ford Accelerates 'Way Forward', Accessible at http://media.ford.com/article_display.cfm?article_id=24261 A summary of the North America Way Forward actions to be implemented by the end of 2008 and resulting financial impact follows. Product-Led Turnaround • 70 percent of Ford, Lincoln and Mercury products by volume will be new or significantly upgraded from today through the end of 2008. The new lineup builds on Ford's strength as America's truck leader while expanding in growth segments, such as crossovers. • Ford will introduce an all-new full-size crossover based on the Ford Fairlane concept. The seven-passenger vehicle for modern families goes on sale in 2008 and will be produced at Ford's Oakville ( Ontario, Canada) Assembly Plant. • Ford will continue to lead the American truck market with a new Super Duty pickup confirmed to go on sale in early 2007 and an all-new F-150 pickup confirmed to go on sale in 2008. The vehicles boast powertrain, design and feature upgrades. • Ford will continue to lead America's sports car market with new Mustang derivatives each year. • The new Lincoln MKS flagship sedan will go on sale in 2008 – packed with more technology and features than any prior Lincoln, including all-wheel drive. Current plans are to produce the vehicle at the company's Chicago Assembly Plant. • Lincoln will continue offering the Lincoln Town Car to meet ongoing demand. After assembly ends at Ford's Wixom ( Mich.) Assembly Plant in 2007, Ford intends to move Town Car production to Ford's St. Thomas ( Ontario, Canada) Assembly Plant. St. Thomas will be reduced to one shift of production, as previously was announced. • Product development work is intensifying through 2008 on creating new small cars and even more crossovers that will go on sale in the future. These vehicles will be based on the company's global vehicle architectures, including "B" and "C" platforms not presently used in North America. • Major investments continue in new gasoline, flexible-fuel, diesel, hydrogen and hybrid powertrains, including additional E- 85 ethanol-powered and hybrid vehicles on the road by the end of 2008. In addition, two out of every three Ford, Lincoln and Mercury vehicles will be offered with fuel-saving 6-speed transmission technology by the end of 2008. • The new products and a voluntary consolidation of the Ford and Lincoln Mercury dealer network are designed to significantly improve the dealers' through-put and profitability by the end of 2008. Accelerated Cost Savings, Leaner Structure, Improved Efficiency • Compared with 2005, annual operating costs will be reduced by about $5 billion by the end of 2008. • Salaried-related costs will be reduced through the elimination of the equivalent of about 14,000 salaried-related positions, which represents approximately a third of Ford's North American salaried work force. The reduction includes the equivalent of 4,000 positions eliminated in the first quarter of 2006. The additional reductions will be achieved through early retirements, voluntary separations and, if necessary, involuntary separations – with most employees expected to depart by the end of the first quarter in 2007. • An agreement with the UAW will expand early retirement offers and separation packages to all Ford U.S. hourly employees, including Ford employees at the company's ACH plants. Employees will begin receiving details by mid- October, and those accepting offers will leave the company by September 2007. • Ford will accelerate by four years its previously announced goal of reducing 25,000 to 30,000 North American manufacturing employees by the end of 2012. The reductions now will be completed by the end of 2008. • The sale or closure of all ACH facilities by the end of 2008 will result in additional employee reductions. • Ford continues to work with the UAW to improve the competitiveness of its U.S. manufacturing facilities. As a result, new competitive operating agreements have been ratified by UAW locals in 30 different U.S. Ford and ACH facilities – and nearly $600 million in annual savings is projected to be realized. Capacity Further Aligned with Consumer Demand • North America manufacturing capacity is being adjusted to 3.6 million units by the end of 2008, down 26 percent versus 2005 – in line with consumer demand and as announced earlier. • Nine facilities will be idled and cease production through 2008, including seven already announced. The two additional plants are the Maumee ( Ohio) Stamping Plant and the Essex ( Ontario, Canada) Engine Plant. • Ford's Norfolk ( Va.) Assembly Plant will be idled a year earlier than planned, and a shift reduction, in advance of idling the facilities, now is planned at Norfolk and Twin Cities ( Minn.) Assembly. • Facilities affected by the end of 2008 include the following: • Atlanta Assembly – to be idled in October 2006 • Batavia Transmission – to be idled in 2008 • Essex Engine – to cease operations in 2007 • Maumee Stamping – intended to be idled in 2008 • Norfolk Assembly – to be idled in 2007, a year earlier than previously planned, with a shift reduction planned in January 2007 • St. Louis Assembly – already idled in March 2006 • Twin Cities Assembly – to be idled in 2008, with a shift reduction planned in 2007 • Windsor Casting – to be idled in 2007 • Wixom Assembly – to be idled in 2007 • Dearborn Truck Plant will add a third crew, beginning in 2007, for F-150 truck production. • All ACH operations will be sold or closed by the end of 2008. • Including Maumee Stamping and Essex Engine, Ford has announced plans to cease production at 16 North American manufacturing facilities by the end of 2012, including seven assembly plants. Financial Impact "Though North America's return to profitability will take longer than planned, the actions we're taking are the right ones, and are fundamental and necessary steps to improving our business structure," said Leclair, the company's CFO. "The planned improvements in our auto operations, in conjunction with Ford Credit – which remains a core asset – will leave us well-positioned for the future. "We are starting from a position of strong liquidity, including our cash, credit lines and VEBA," Leclair added. "We will continue to focus on enhancing our liquidity, building upon our decision to explore strategic alternatives for Aston Martin and the board's intent to eliminate our quarterly dividend." Automotive Operations • Full-year pre-tax special items for 2006 are expected to be significantly increased from the $3.8 billion we estimated previously to reflect the accelerated Way Forward actions. Further details will be provided when Ford announces Third Quarter financial results next month. • Full-year profitability in North American automotive operations not expected before 2009 . • Ford and Lincoln Mercury U.S. market share is projected to be in the low-16 percent range at the end of 2006. • A further share decline is expected as production of the Ford Taurus sedan and Mercury Monterey minivan ends in 2006 and production of the Ford Freestar minivan ends in 2007. The end of these vehicles will reduce the company's sales to daily rental fleets. • With the investment in new products and improvements in quality, Ford expects to be in the 14 to 15 percent market share range going forward – with a focus on profitable retail share. • South America and Ford of Europe still are expected to be solidly profitable in 2006. However, full-year operating losses now are expected in 2006 for Asia Pacific and Africa, as well as the Premier Automotive Group – primarily reflecting lower volumes. Liquidity • Ford Motor Company's 2006 year-end liquidity is expected to include automotive gross cash of about $20 billion, including marketable and loaned securities and the effects of $3.4 billion of VEBA. The company will continue to have committed automotive credit facilities totaling more than $6 billion . • Ford Motor Company's Board indicates that it will suspend payment of the quarterly dividend on its common and Class B Stock beginning in the fourth quarter of 2006. Appendix B: Porter's Five Forces Appendix C: Cost Analysis Ford GM Difference Production (in thousands) North America 3,286 4,828 -1,542 International 3,532 4,319 -787 Total 6,818 9,147 -2,329 Fixed Cost per Unit $8,411 $6,057 $2,354 Variable Cost per Unit $14,491 $11,895 $2,596 North America Effect Expected Cost Savings (in millions) $5,000 US Car Production (in thousands) 3,286 Cost Savings per Car in NA $1,522 Global Effect Expected Cost Savings (in millions) $5,000 Total Car Production (in thousands) 6,818 Cost Savings per Car in NA $733 Data Source: Deutsche Bank "Can Ford be fixed? First impressions of Alan Mulally" October 24th, 2006 Appendix D: Brand Positioning Source: Ford Motor Company, North America "Way Forward" Business Review, January 23, 2006 Appendix E: Percent Sales in US by Division and Type U.S. Sales By Brand Oct 2006 Car Truck Total Ford 64433 118755 183188 Mercury 6232 4045 10277 Lincoln 5754 3012 8766 Totals 76419 125812 202231 % (Category) 0.37788 0.62212 Source: PR Newswire, Nov 1st, 2006, "Ford's U.S. Sales Rise for the 2nd Straight Month" Appendix F: Additional Cost Savings Fixed Cost Parity With Foreign Automakers (NA Only) Current Cost Difference Per Car 2500 Savings Per Car in NA Under $5 Bil Cost Cuts 1522 Additional Cost Cuts Needed Per Car 978 Number of Cars Sold in NA (in thousands) 3,286 Total Necessary Cost Savings (in Billions) 3.21371 Fixed Cost Parity With GM (NA Only) Current Cost Difference Per Car 2354 Savings Per Car in NA Under $5 Bil Cost Cuts 1522 Additional Cost Cuts Needed Per Car 832 Number of Cars Sold in NA (in thousands) 3,286 Total Necessary Cost Savings (in Billions) 2.73395 Sources For Cost Difference/Car Previously Cited Assumption: Costs Are Evenly Spread Out Per Unit Across Global Operations Global Cost Parity with GM Excess Fixed Costs For Ford (in Billions) 16 Current Way Forward Reduction in Costs (in Billions) 5 Possible Additional Cost Savings (in Billions) 11 Value For Excess Fixed Costs For Ford Taken From Deutsche Bank, Previously Cited
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Too Cute For Words!
by Pets
Like us on Facebook
It's time to get clever! A picture is worth a thousand words but those messages vary from person to person. This cat is definitely wet (and not too pleased in my opinion). . . but what do you think he's thinking? Suggest quotes or captions for this photo in your comments below, and I'll do a round-up next week of some of my faves.
Read More Too Cute For WordsQuotable
scottiegirl 7 years
Why did you do this to me? I did not need a bath. I smelt good as I was...
fuzzles 7 years
What part of "NO WATER" do you not understand???
fuzzles 7 years
Kitten gets tanked on New Years Eve.
fuzzles 7 years
Dad forgot to put the toilet seat down again!
fuzzles 7 years
ElleJay 7 years
You know how they say: "It's raining cats and dogs"? Ta-da.
audreystar 7 years
"I told them if they got me wet I'd turn into a gremlin! Now they will pay!" :evil:
foxytnns 7 years
"Gosh, the things you'll do to catch a mouse!"
tmmkitten 7 years
lets see how you like being wet, tomorrow, your getting a special "present" in your shoe!
alsoto_mulhall 7 years
In Smeagol voice: It burns! It burns us!
princess_dork 7 years
Eeek!! Cheap shampoo!! Get it off, get it off me!!!
whizbabe 7 years
"So much for the slicked-back hair look"
butterfly-chic 7 years
kitty to owner is saying " Im wet, cold, and where the hell is my TOWEL "
wakeupandora 7 years
eek! typo! what i meant was: Kitty [to owner]: You are NOT who I thought you were!
wakeupandora 7 years
kitty [to owner]: 'you are now who i thought you were'.. :(
Link Love
- Find out what Taylor Swift said about her doppelgänger — Us Weekly
- Justin Guarini, is that really you?! — HuffPost Celebrity
- Here's what Outlander star Sam Heughan is like in person — Lainey Gossip
- Julia Roberts has a major problem with Nicole Kidman — Dlisted
- Lena Dunham's new written piece is causing a stir — ET
- Inside Kate Mara and Ellen Page's day at Disneyland — JustJared
- Kate Upton is showing major cleavage for Guess — Hollywood Tuna
- Which Britney Spears video turns 15 today? — Pink Is the New Blog
- Rita Ora's airport attire makes quite the statement — The Superficial
- Land a copy of Madonna's latest album — popbytes


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Bruce Jenner Involved In Fatal Car Crash
Former Olympian and "Keeping Up with the Kardashians" star Bruce Jenner was involved in a multi-car accident Saturday that left one person dead.
Former Olympian and "Keeping Up with the Kardashians" star Bruce Jenner was involved in a multi-car accident Saturday that left one person dead.
Suge Knight pleaded not guilty Tuesday to charges of murder, attempted murder and and two counts of hit-and-run after an incident that left Knight's friend, Terry Carter, dead.
Bobbi Kristina Brown, only daughter of the late Whitney Houston, remains unresponsive at a Georgia hospital after being discovered face down and unconscious in a bathtub at her home Saturday.
"American Sniper" spent its third week at No. 1 this Super Bowl weekend, taking in an estimated $31.8 million, making it the biggest Super Bowl weekend grosser ever.
Bobbi Kristina Brown, daughter of singers Bobby Brown and the late Whitney Houston, was rushed to a hospital Saturday after being found unresponsive in a bathtub at her home in Georgia.
Hip-hop mogul Marion "Suge" Knight is being investigated by the Los Angeles Sheriff's Department for his involvement in a hit-and-run accident which left one person dead and another injured.
Sunday's Big Game is a holiday I look forward to every year, and this year is star-studded!
Think you got a sweet message from Taylor Swift? Think again.
Better hold on to something, geeks and geekettes!
Apparently, being an "American Idol" winner isn't all it's cracked up to be.
Was I the only one who almost didn't recognize Zach Galifianakis at the SAG Awards last night?


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Education News Archive - August 24, 2011
WebShoz has created the first scalable video embedding system that allows a display ad to play multiple videos immediately upon roll-over, The Videobar®! The "Heads & Tails Videobar®â€
Videos are the latest in online parts retailer's mission to save do-it-your-selfers money and give them the confidence and knowledge to perform repairs themselves. Encino,
AutoMax Recruiting And Training, the country's most requested automotive sales recruiting and training company, announces today, a strategic partnership with Hire The Winners, the creator of
The Mesothelioma Victims Center is the only group, or organization that offers US Navy Veterans, individuals, or families dealing with a mesothelioma diagnosis with a tailor made mesothelioma
A Tallahassee teenager's future is forever changed when her misdiagnosis of "stress" turns out to be terminal liver cancer.
Rent My Vacation Home (RMVH Network) franchise opens Rent A Cape Cod Vacation Home located at 1070 Iyannough Road ,Suite 103,Hyannis, MA, 02601-1871, phone (508)-534-8200. Cape
The Semi Truck Accident Victims Center has no equal with respect to providing with a immediate national response, anywhere in the United States for a victim, or loved ones of a innocent passenger
deFacto Global, Inc.
ESL Shop, a trusted one-stop-shop for ESL books and teaching resources is now delivering materials to learners and teachers of English throughout the
Riverside residents Mike and Melissa Erskine were recognized for their outstanding performance as ComForecare Home Care Franchise owners during the training event in Bloomfield Hills, Michigan
- Large; stout; burly.


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Posts filtered on Category
Feldman's gem locks up Silver Boot for Astros
Box score The second shutout of Scott Feldman's career guaranteed that the Astros, for roughly a year's time, have in-state supremacy in the baseball realm. The veteran allowed three hits in a 2-0 win over the Rangers at Minute Maid Park, returning the Silver Boot to the Astros. The Astros are 10-5 against their in-state […] [Read More]
Astros' Brad Peacock aiming for a strong finish
Astros righthander Brad Peacock had a 6.01 ERA in 2012, when he was pitching for the Oakland A's Class AAA affiliate in Sacramento. So he laughed a little the day before his start in Wednesday's 5-4 Astros loss to the A's when asked if he has struggled before as he has of late. "Oh God, […] [Read More]
Scouting report: Astros vs. Texas Rangers
Three things to watch in the four-game series against the Texas Rangers at Minute Maid Park: 1. The Astros took over fourth place in the American League West on July 9 with an 8-4 win over the Rangers in Arlington, completing a three-game sweep that sent the Rangers to the cellar. That was in the […] [Read More]
Astros minor leaguer Josh Hader named California League Pitcher of the Year
CLEVELAND — Lanky Class AA Corpus Christi lefthander Josh Hader, who has drawn comparisons to Chris Sale since he was acquired in the deal that sent Bud Norris to the Orioles last year, was named the 2014 California League's Pitcher of the Year for his impressive showing at Class A Lancaster before he was promoted […] [Read More]
Collin McHugh in search of a personal trifecta
CLEVELAND — Astros righthander Collin McHugh will take the mound Saturday against the Cleveland Indians in search of the first three-game winning streak of his career. McHugh (6-9, 3.00 ERA) has won two in a row twice before this current two-game winning streak, but he has yet to string three in a row. "Truthfully, I've […] [Read More]
Astros reliever Kevin Chapman finally gets a taste of Fenway
BOSTON — There's always a few times a season when a player has to get to the big leagues from the faraway reaches, scrambling to make a plane or a boat or buggy because of a last-minute need. Astros lefty Kevin Chapman woke up — sort of — at 3:45 P.T. on Friday in Fresno, […] [Read More]
Darin Downs is latest Astro to deal with oblique issue
BOSTON — Obliques and intercostals should be taboo around the Astros. Lefty reliever Kevin Chapman was recalled from Class AAA Oklahoma City on Friday, a move necessitated by discomfort in the area of lefty Darin Downs' right oblique. For now, Downs remains on the active roster, leaving the Astros a man short for Friday's game […] [Read More]
Scouting report: Astros at Boston Red Sox
Three things to watch in upcoming series vs. the Red Sox: 1. With 41 games to go, Jose Altuve is on pace to break Craig Biggio's Astros' single-season hits record of 210. He leads the majors with 166 hits and 51 multi-hit game. By comparison, Red Sox second baseman Dustin Pedroia has 132 hits. 2. […] [Read More]
Brad Peacock looking to snap out of recent funk
Astros righthander Brad Peacock (3-8, 5.44 ERA) will attempt to snap his personal three-game losing streak Monday night when he faces the Minnesota Twins. Peacock gave up eight runs over five innings on Wednesday against the Phillies and seven runs over 3 2/3 innings against Oakland on July 23. He also was pulled after giving […] [Read More]
Astros continue to give Darvish, rival Rangers their comeuppance
Box score Practically everybody smothered the Astros last year as they finished with the worst record in baseball for the third consecutive year. Yu Darvish and the Rangers, however, took the biggest bites to push their Lone Star Series rivals to a franchise record 111 losses in 2013. On Saturday night, however, the Astros provided […] [Read More]
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1999 Jaguar XJ8 Repair and Maintenance
A guide to problems, costs, maintenance and repair for your 1999 Jaguar XJ8
- Restricted performance
- Car is stuck in valet mode. Lost key and fab. Only have valet key. Open trunk
- A/c will cool good then warm humid air. New compressor and still same problem
- What would cause my car to only run a few seconds and die?
- Engine light on with restrictive performance in message what does this mean
- Head Gasket(s) Replacement $2,205 - 3,707
- Water Pump Replacement $251 - 462
- Valve Cover Gasket(s) Replacement $395 - 581
- 140,000 Mile Service $199 - 294
- Wheel Bearing Replacement - Front $899 - 1,173
- South Side Auto Service Inc. (718) 305-4810 | 7.91mi
- Ray & Dana's Inman Auto Care (732) 703-7919 | 3.46mi
- Zaloom's Auto Repair (646) 663-5728 | 8.95mi
- Route 1 Sunoco (732) 253-4623 | 8.11mi
- Carracino's Auto & Truck (908) 364-5589 | 8.49mi
1999 Jaguar XJ8 Problems
The cup holder in the front center arm rest is flimsy and may break, making it impossible to close the cup holder assembly.
On this V8 engine, timing chain problems are very common. Because the timing chain tensioners were made from plastic, they can fail prematurely and cause serious engine damage. A noticeable engine noise while idling or during a cold start can indicate a timing chain tensioner problem. The engine noise may also be accompanied by a rough or uneven engine idle. Improved components are available to remedy this problem.engine oil consumption.
1999 Jaguar XJ8 Questions
Happens every time is used, do not know if it will cool or sweat it
I parked my car yesterday and then tried to start it and it would only run for a few seconds and it ran rough those few seconds. The check engine light and battery light was on during those few seconds. I don't know technical stuff but also the fail safe engine mode light was coming on at c...
engine light on all the time. Restrictive performance goes on and off.
1999 Jaguar XJ8 Reviews
Bought mine in 2000 and have loved it ever since. Drove it for 10 years with hardly any problems. This year had to have the timing chain replaced and thermastat earlier this year, which was NOT cheap. It needed towed today, and we think it might be the fuel pump.... Even with that said.... LOVE LOVE LOVE my car!
i have 1999 jaguar xj8,had lot of work done but run very well now


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Arizona Cardinals
Patrick Peterson: Offense 'can't give up two touchdowns'
Patrick Peterson is only two years removed from his college career at LSU, yet the 22-year-old may be the only player on the Arizona Cardinals' 53-man roster with the authority to call out any of his teammates.
After all, he's done just about everything in 2012.
Peterson, who has served as a cornerback, running back, wide receiver, punt returner and gunner this season, displayed that rare cachet after Sunday's 28-13 to the Chicago Bears.
"As an offense, we can't give up two touchdowns," Peterson said. "Coach Whisenhunt really hit that on the head today."
While Peterson and Arizona's defense held Bears quarterback Jay Cutler in check (12-of-26 for 141 yards), the Cardinals were forced to play from behind all afternoon on Sunday, as a fumble return for a touchdown by Chicago's Zack Bowman in the first quarter and an interception return for a touchdown by Charles Tillman in the third quarter put Lovie Smith and Co. in the driver's seat at University of Phoenix Stadium.
Although the former No. 5 overall pick had some harsh words for the offense, he didn't limit his criticism to only one side of the football.
"At the end of the day, we can't let those guys score," said Peterson. "We have to do a better when the offense does turn the ball over to hold those guys to three points."
The Cardinals' defense limited Chicago's offense to only 15 points, but they did allow over 150 yards on the ground.
With a week left in their season, the Cardinals sit in the basement of the NFC West, and are much closer to a top 5 draft pick than they are to playoff contention. Despite a forgettable campaign in 2012, Peterson said the team would still try to grow together over their final 60 minutes of play next Sunday.
"We're a team that never wants to give up," said Peterson. "We want to play hard until the fourth quarter when that clock says 0:00. That's our mentality coming into any game, win, lose or draw."
The Cardinals travel to San Francisco to take on the division-leading 49ers next weekend. The game still has plenty of meaning for Jim Harbaugh's squad, as well. After being blown out 42-13 Sunday night, the 49ers still need a win or a Seattle Seahawks loss in Week 17 to clinch the NFC West.
Most Popular
Cardinals Audio
- Kurt Warner- NFL Network analyst - Tuesday March 31Kurt Warner describes what he saw at Jameis Winston's pro day.
- Daniel Jeremiah- NFL Network analyst - Friday March 27Daniel Jeremiah could see the Cardinals drafting a running back in a round after the first round.
- Kevin Guy, AZ Rattlers head coach - Friday March 27Coach Guy talks about losing players to the NFL and the challenges the Rattlers face this season.
- Charles Robinson, Yahoo! Sports NFL reporter - Tuesday March 24Charles Robinson believes that Adrian Peterson's relationship with the Vikings will only get worse.
- Sal Paolantonio- ESPN NFL analyst - Tuesday March 24Bruce Arians told Sal Paolantonio that there are "no serious discussions" about trading for Adrian