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The Dark Knight Rises
From the critics
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CommentAdd a Comment
WORST MOVIE EVER!!! Batman Begins and The Dark Knight were so much better, because they had Joker, and Christian Bale was really good-looking. The plot in this movie was all messed up, especially with Bane and Catwoman. They didn't even get the characters right!
I did not understand this movie at all, what was the story ? Anna Hathaway was so awful that she should try to take an acting lesson or two. And Tom Hardy was very difficult to understand, what with thing on his face. You had to strain to hear what he was saying. As with every superhero movie that tries to balance 2 villains, this movie too falls flat on its face. It's long, boring, with nary a story to hang unto, just action scenes that don't amount to anything. By the time you get to the last half-hour, and things start to move, you wonder, why didn't they shave an hour out of that thing ???? Granted, its not as awful or as ridiculous as the second one (which people only say they liked because that Joker actor died while making it and people are ninny that way...) but still... A waste of time... Watch the real Batman movies with Michael Keaton instead :)
The first installment of the series with Christian Bale was completely original, but this 3rd installment seemed to be losing steam. I liked the supporting cast of Morgan Freeman, Michael Caine, Marion Cotillard, Tom Hardy and Anne Hathaway. I would have liked to see a few scenes where Hardy takes off the mask so that we could get a chance to see more of his acting abilities of this menacing character Bane.
One of the best Batman movies!
Tom Hardy steals the show as Batman's one true nemesis: Bane!
Not as good as The Dark Knight, But better than Batman Begins. Christopher Nolan was meant to do Batman.
I enjoyed this much better than the second batman movie but still nothing special here. The story is nothing great (is there one??), the villain is garbage, cat woman is idiotic, the bat toys are boring and batman has that awful voice. I wouldn't recommend this unless you have seen the other two movies.
Happy 75th birthday Batman!
Try to avoid this one If possible.
Mild excitement. Weak plot. While this is a movie, I'm not sure if any police for that matter would simply run towards a group of villains shooting automatic weapons. The only good about this movie is the ending… ZZzzzzz….
A very intriguing story with some real bad-ass characters. Generally, the plot is very mind-blowing. Unfortunately I can not be convinced about all police get trapped into a tunnel like they are all too stupid to spread out their watch. Other not-very-viewable things are the slow fight scene (e.g. a group of men tackling batman but they wait for others to go down before attacking batman, like taking a rota to clean the floor). The flying bat mobile is totally a piece of vehicle I love to own one day. I don't think broken back (vertebral column) could be healed so soon without proper care. Catwoman is less charming than that of Michelle Pfeiffer who was really playful and obnoxious. Maybe it is a generation thing about my point of view. Yes, it is a good movie but with many holes. Don't kill me because I have a different opinion!
QuotesAdd a Quote
Bane: Nobody cared who I was until I put the mask on. CIA Agent: If I take off your mask, will you die? Bane: It would be extremely painful. CIA Agent: You look like a tough guy...... Bane: For you. CIA Agent: Was getting caught part of your plan? Bane: Of course. CIA Agent: Well you did it! Now what's the next step in your master plan? Bane: Crashing this plane..............with no survivors!!!
""Let's not stand on ceremony here. Mr. Wayne."
Bane during the National Anthem : "What a lovely, lovely voice."
"One person can make a difference and every person should try." –John F Kennedy
"Darkness cannot drive out darkness, only light can do that. Hate cannot drive out hate: only love can do that." ― Martin Luther King, Jr
The mask isn't for your protection, but for the people you care about - Batman
Bane: "The fire rises."
Batman: (on a rooftop, talking with Selina. Turns away briefly, then turns back, and realizes she's gone) "So that's what that feels like."
Bane: "...Ohhhh, you think darkness is your ally... But you merely adopted the dark... I was born in it! Molded by it... I didn't see the light until I was already a man. By then it was nothing to me but BLINDING! (grabs Batman from the shadows and continues to beat him) The shadows betray you, because they belong to me! (repeatedly punches Batman in the face, breaking his cowl) I will show you where I have made my home whilst preparing to bring justice. Then, I will break you. (Hits detonator, blowing a hole into the bottom of Wayne Enterprise) Your precious armory, gratefully accepted! We will need it."
Bane: "Ah yes! I was wondering what would break first! Your spirit... (dead-lifts Batman over his head) ...or your body!" (slams him down on his knee)
AgeAdd Age Suitability
yellow_dolphin_217 thinks this title is suitable for between the ages of 12 and 11
Green_Fox_6 thinks this title is suitable for 12 years and over
NoticesAdd a Notice
Frightening or Intense Scenes: If you don't like masks, you'll get nightmares from Bane.
Violence: It's a very intense PG-13 experience.
Frightening or Intense Scenes: Intense with violence
Violence: Intense with violence
SummaryAdd a Summary
Eight years after the death of Harvey Dent, the Batman is tested to return to Gotham when he is pit against the villainous Bane and the mysterious beauty Selina Kyle. But deep in the shadows, the League of Shadows has devised a plan for revenge against Batman.
It has been eight years since Batman vanished into the night, turning, in that instant, from hero to fugitive. Assuming the blame for the death of D.A. Harvey Dent, the Dark Knight sacrificed everything for what he and Commissioner Gordon both hoped was the greater good. For a time the lie worked, as criminal activity in Gotham City was crushed under the weight of the anti-crime Dent Act.


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5.5 of Ed Wort's Haus Pale Ale here. Primary airlock was going crazy last night.
Brewed a 40% rye Roggenbier on the first and today I'm getting in a caribou slobber variation.
Vanilla Cream Ale
On a cold & drizzly Brew Year's Day, I fired up the 3-tier in my garage and cooked up my "3 Crops 3 Hops" cream ale recipe: barley, corn & rice with Centennial, Hallertauer, and Saaz. Should be ready for the Superbowl to help convert the BMC crowd.
Skeezer's clone for Firestone Walker Wookey Jack black rye IPA. Can't wait!!!
All mosaic hopped pale ale for this guy.
I'm on the dregs of my on-hand ingredients now so will be brewing something of a Bière de Garde with 4oz of smoked malt in the mix...1.073 est. OG.
I still have not decided on a yeast yet...probably one of the saison strains or Belgian wit.
Two weeks to ferment, two more in the kegs
but in just one night it was drained to the dregs
i will be kegging a german pilsner. then making a german dark pilsner and pouring the wort right onto the yeast cake coming this sunday.
New Year's Eve. Brewed a Scotch Ale with just enough peated to notice... I hope.
Made the Bee Cave Bavarian Hefe yesterday.
Today making a Deschutes Black Butte Porter clone attempt. Back to back brew days to start 2013! Woot woot!!!
Happy Brew Year!


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Kriss Russman studied at Caius College, Cambridge where he received a doctorate in music. He worked as a producer and director for BBC Television's music and arts department for ten years and his broadcasting achievements include an EMMY nomination, a US Cable Ace trophy, an award from Britain's Royal Television Society and two awards from the Royal Philharmonic Society.
As a conductor and composer, he has performed with major European companies including the Hungarian State Opera, Prague State Opera and the London Symphony Orchestra. His first opera 'Happy Birthday, Mr President' was commissioned and premiered by the Rostock Volkstheater in Germany in 2013. He has just realised and completed George Butterworth's Orchestral Fantasia which was left unfinished before Butterworth was killed in the First World War. He will conduct the work with the BBC National Orchestra of Wales on a Butterworth disc for BIS Records to be released in 2016, the centenary of the composer's death, and the BBC Scottish Symphony Orchestra will give the UK premiere in November 2015.
E-mail: Samia Spice (email@example.com)
Telephone number: 020 7344 1028


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Category Archives: Things To Do in New York City
Delving into New York's Art Scene
On this blog we have covered art museums extensively, and for good reason, as New York is a literal treasure trove of art. But that doesn't mean all of the city's artistic gems are concentrated in the hands of the Met, Guggenheim or Moma. If guests of our boutique hotel … Read More
A Taste of Harlem
One part of Manhattan that's mostly overlooked by tourists is uptown's Harlem. The neighborhood, roughly defined as anything between Central Park and 155th Street, is home to a diverse ethnic mix of Caribbean, African and Latin American denizens. Though once regarded as a rough-and-tumble place, this reputation is no longer … Read More
Two Contrasting Views of NYC
There aren't enough adjectives to properly describe the experience of visiting New York. Everything is simply more exciting in the city: the buildings are bigger, the pace is quicker, the shops are trendier and the attractions are grander. Guests staying at our boutique hotel The MAve have a limitless amount … Read More
A (Cheap) Night at the Museum
New York has so many world-class art museums that it can be incredibly expensive to see them all. Thankfully, however, a number of the museums offer special promotions one or two nights of the week, when they lower their prices and stay open late, which, for tourists, is a winning … Read More
Visiting the Metropolitan Museum of Art
One of the great parts about visiting NYC is the wealth of excellent museums and cultural attractions. But while there are an almost endless amount of art museums worth visiting, the Metropolitan Museum of Art—simply called The Met—is head and shoulders above them all. Situated on Central Park at 82nd … Read More


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Visit create.airbnb.com »
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Your participation helps keep Airbnb a safe and trusted
community, and it doesn't go unnoticed!
Friendly and clean 35 year old host who loves to offer his lovely apartment whilst away himself.
Ivar has completed online and offline ID verification.
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wir haben unseren aufenthalt in ivars schöner wohnung sehr genossen. die wohnung entspricht der beschreibung und ist gut mit allem ausgestattet. fürs erste frühstück fanden wir alles nötige im kühlschrank. auch wenn wir ivar nicht persönlich angetroffen haben, hat er alles optimal organisiert und uns mit vielen nützlichen informationen versorgt. die kommunikation verlief freundlich und problemlos. alles in allem sehr zu empfehlen!
The apartment was quite perfect. There is everything you need for comfort stay in Amsterdam. Ivar and his girlfriend Femke are very great hosts. The apartment includes very beautiful roof terrace and a balcony which can provide very nice views while seating outside taking diner or breakfast and enjoying fresh air. The place itself has enough space to have a rest, cook, sleep and just enjoy life.
Bikes which are included may take you everywhere in Amsterdam.
Me and my wife spent wonderful days during our honeymoon
This was our first experience with AirBnb and we were very lucky.
Ivar's indications were perfect and he was waiting for us down on the street when we arrived.
He gave us all the information about the apt and left us an useful house manual.
The apt was bigger than we thought, and very comfortable.
We had just a little problem with bathroom light, it was very low, so when my lady needed to do her make up, she went crazy ^_^
We used Ivar's bikes all the time, and by bike, the apt is 10 minutes from the center (and other must see points). The neighborhood is very peaceful and definitely you will fall in love with this amazing city.
Communication with Ivar was good, the data to get there very accurate as well as instructions for use of the apartment.
His friend was waiting us to make the checkin, and she was really friendly and we chatted a bit about the place and things to do during your stay.
The place is really comfortable, spacious with a well equipped kitchen and an excellent central heating system. The shower and hot water great too.
If the weather is good, the terrace is a really nice place to spend some time.
It is located near the Vondelpark, and with the bikes can quickly reach the museums area, and few minutes more to the center of Amsterdam.
We had a very pleasant stay and definitely would repeat the experience on a next trip to Amsterdam.
Thanks Ivar and Femke!!
Ivar is very reactive and he gave all the information we needed, very quickly.
The apartment is very nice, we were three guys and it was ok.
The area is very quiet. You need a car or the tram to go to the city center.
Our trip vas very nice and Ivar's apartment is a very good way to enjoy Amsterdam.
Ivar and his girlfriend were really nice people. They left me some brilliant notes on how everything works, and because of the directions ivar gave me before i left i was able to find the apartment with ease.The apartment itself is lovely, really cosy, i had the most comfortable time there, everything was spotless, it was very clean. The roof terrace was brilliant in the sunshine.
Thanks so much guys i had an amazing time and a brilliant experience
A great place to stay and fantastic host. Ivar's place is located near the center of the city and the apartment is super cozy with its roof terrace. I loved his interior with lots of art pieces displayed. The location has easy access to Leidesplein (the place with cafe, restaurants, entertainment and coffeeshops etc.) by tram, on foot and of course by bike. I'd definitely recommend Ivar's place for people who want to deep dive into the local's living in Amsterdam.
Femke et Ivar sont des gens absolument charmants et très souriants, ils ont apprécié le petit déjeuner que je leur ai servi, m'ont complimentée sur la maison et l'accueil. J'ai eu beaucoup de plaisir à m'entretenir avec eux.
Vraiment sympa et joyeux .
Great Guests
very friendly and communication was smooth
would love to host them again
Lovely friendly guest!
Ivar is a wonderful guest. He is warm, bubbly, enthusiastic and a real pleasure to have hosted! I hope he will be back sometime soon!!!
Ivar was a great guest. He is very nice, communicative and respectful of the place. I would definitely advise them as a guests here on airbnb. I would be really happy to have them back anytime. Thank you!
Ivar was such a nice guest. Seizing every moments and sharing his joy and happiness with us.
It was delightful to share time with him.
Stayed at his place a few days.. my goal was to enjoy Amsterdam.
With the center relatively close to the app. I could really get about. Tram is just 1 min walk.. Department store just 3-4 min. You can really save lots of time. So you can use your vacation time to see the city of Amsterdam.
If you enjoy walking, I do. You can take your time to explore by foot. Cycling is a other great option. Don't worry "Dutchies(locals)" can see if your a tourist on the bike. So Take that bike and start to explore. Its the Best!
After all that exploring you can head back and enjoy the app. itself, the free wifi , The libary. and most of all the coffee machine where my best friends. If you wish you can stock up on a few beers.
But best of all must be the Super Friendly host. With travel tips and friendly chat. Makes this a great home away from home in Amsterdam. To enjoy the city or stay inside on a cold winter night. For everybody something at Ivar's app.
I always enjoy staying at Ivar's place. The area is family friendly and very near to city center at the same time. There are lots of nice bars and restaurants close by and a short bike ride will take you to the Vondelpark; here you can enjoy a lovely stroll, a coffee or a picnic. After a long day of walking around the city, it is great to come back to Ivar's place. It is spacious, has a cosy big kitchen with balcony and a lovely roof terrace. And in winter time, his central heating makes the place even lovelier ;). Enjoy!


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3 people found this helpful
"Nightmire "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Culture & Values
- Career Opportunities
I worked at hhgregg full-time (less than a year)
You will get exposed to all the latest. electronics and appliances.
You didn't get paid what you earned . People could return an item months after you sold it and would lose the sale to the mangers favorite.
The company is completely corrupted from the ground up. You need to have a base and a fair system of pay. You also need to give access to upper mangment as the local district is completely corrupted.
- Any Location
- Any Job Title
4 people found this helpful
"Unfair work practices "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Culture & Values
- Career Opportunities
I worked at hhgregg full-time (less than a year)Pros
Co-workers were experienced and knowledgeable.Cons
Poor Management
Awful employee pay model
Long hours punctuated by free(to hhgregg) labor
The company is commission based only, despite up to 12 hours weekly you must be dedicated to improving the store, with no compensation. Utterly ridiculous. 2 hours before store opens to set up the place up. (no customers so no pay), 2 hours post close to clean the place (no
customers no pay) multiply this by 3 or 4 times a week, and you are donating 12 hours+, rarely less to HHgregg for free. I have a family to feed, can't donate 12 hours of my time so store is pretty and equipment is ready for sale. No problem working the 60 hours a week, but not when 12 hours of it are a donation. Utterly absurd pay model. Commissions are non-existent unless you sell a very poorly reviewed, service plan, that eventually comes back and haunts you in the form of dissatisfied customers. Delivery handled by outside agent who either messes up the shipment, or because they are so ill handled, just botch things up. Never enough staff in warehouse, you end up having to get your own product from the back and waste more of your un-payed time. Almost all of the experienced staff left within the first 4 months of employment. Replaced by inexperienced job seekers willing to take any abuse doled out. Pay model favors the company completely, with their goal to get as much free from their employees as possible.Advice to ManagementAdvice
If your plan is to work employees for no pay, then I have no advice, because all benefits are to the firm, with none to employee. On the other hand if you want loyal hard working employee base, change the pay modelDoesn't RecommendNegative OutlookDisapproves of CEO
"Its nice work if you can get it "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Culture & Values
- Career Opportunities
I have been working at hhgregg full-time (more than a year)Pros
getting to help people find their right TV or appliance and know they will enjoy them without worry.Cons
Long hours, standing all day, sometimes overly cut throat or intrusive sales people, lack of commitment or community from some sales people.Advice to ManagementAdvice
Pull more from inside to fill management slots, getting people with experience from competitors can ease a little bit of training but there is a reason we are doing better that the other guys and bringing in people who do things 'their' way may not pan out.RecommendsPositive OutlookNo opinion of CEO


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Investor pushes for PepsiCo to buy Mondelez
Activist investor Nelson Peltz said he wants PepsiCo to buy Oreo cookie maker Mondelez and spin off its own underperforming beverage unit.
During an interview on CNBC, Peltz said he talked about the proposal with PepsiCo CEO Indra Nooyi. He said he has a meeting planned with Mondelez's CEO in the next couple of weeks.
Speculation that Peltz could push for a combination of the two snack-food giants began earlier this year, with his Trian Fund Management disclosing stakes in the two companies.
The New York native is known for building stakes in companies then forcing change.
Mondelez and PepsiCo, whose financial performances have both been under scrutiny lately, have said they're happy with their current portfolios. PepsiCo makes Frito-Lay snacks.
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Shin Bong Sun Wiki
M.I.B's Kangnam Is Shin Bong Sun's Ideal Man
Comedian Shin Bong Sun shows her affection to M.I.B's member Kangnam. The star revealed that Kangnam is her dreamy man.
During a recent shoot for MBC's Hello! Stranger, Shin Bong Sun took a trip with the members in celebration of the New Year. Shin Bong Sun enjoyed the trip with the members as the one-day special guest.. ... Read more
Shin Bong Sun shared about her popularity after her nose surgery
In recent times, Shin Bong Sun confessed that she had her nose surgery. She added that it brought a lot of change to her popularity.
On the October 11 broadcast of MBC's variety talk show "Quiz to Change the World," the three MCs and the panel of guests discussed the topic of namelessness, and going through periods of not being well known.. ... Read more
Shin Bong Sun points out her new nose and reveals she once cried because of Kim Gu Ra on "Radio Star"
This week"s airing of MBC "Radio Star" featured Rhymer, Shin Bong Sun, and Kim Jong Min.
On this day, as soon as Shin Bong Sun stepped into the studio, the MCs of "Radio Star" carried on with their usual blunt jokes and scolded her for her outfit choices as well as her hairstyle to which Yoon Jong Shin jokingly asked, "Did your dad cut it for you?". ... Read more
Kim Shin Young and Jo Se Ho to replace Shin Bong Sun and Heo Kyung Hwan on "Happy Together 3"
There will be changes in cast line up on KBS2″s "Happy Together 3″ as Shin Bong Sun and Heo Kyung Hwan are announced to be leaving the show.
On July 29, Han Kyung Chun reveals that Shin Bong Sun and Heo Kyung Hwan already filmed their last episode on July 26. He also announces the new members who are going to fill the spots and they are none other than Kim Shin Young and "Roommate" cast Jo SeHo.. ... Read more
Shin Bong Sun and Heo Kyung Hwan to leave "Happy Together", Kim Shin Young and Jo Se Ho to join
"Happy Together 3" family members Shin Bong Sun and Heo Kyung Hwan will be leaving the show!
CP Han Kyung Chun told TVDaily on July 29, "Shin Bong Sun and Heo Kyung Hwan have left the show after filming their final episode on the 26th. Although it"s not a new season yet, we"re making small changes. Shin Bong Sun has been on the show for a long time, and it"s been difficult for Heo Kyung Hwan to continue after joining "I Am a Man".". ... Read more
Shin Bong Sun and Heo Kyung Hwan Leave "Happy Together 3," Kim Shin Young and Jo Se Ho Join
Comedians Shin Bong Sun and Heo Kyung Hwan will be leaving KBS2TV's "Happy Together 3."
According to KBS2TV, the two MCs filmed their last episode on July 26. . ... Read more
Comedian Shin Bong Sun Reveals Her New Nose
Comedian Shin Bong Sun showed off her new nose on the MBC FM4U radio show "This Morning Is Jung Ji Young." On the show, Shin Bong Sun also revealed a recently recorded song "Bong Sun's Project 2 – Let's Laugh." . ... Read more
Shin Bong Sun reveals: "I redid my nose."
Comedian Shin Bong Sun made a guest appearance on the most recent broadcast of SBS's radio program "Cultwo Show" where she opened up about doing cosmetic surgery for a more beautiful nose.. ... Read more
Yoo Yun Suk reenacts his famous neck-grab kiss scene with Shin Bong Sun + performs OST 'To You'
The tvN special "Reply Through Song 1994" aired on January 31 and featured some fun times with the cast members as well as the MCs.
On this day, MC Shin Bong Sun saw an opportunity and asked Yoo Yun Suk if the two could reenact his kiss scene with Go Ara in drama "Reply 1994." He first asked, "Do I really have to?" then went to the front of the stage with Shin Bong Sun. . ... Read more
IU transforms into comedian Shin Bong Sun when she's angry
Singer IU is currently the model for online game "Dungeon and Fighter".
In a recent TV commercial for the game, IU showed off her powerful and fierce side to fight against her enemies in the snow. . ... Read more


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SYNOPSIS: Living in isolation since the death of his beloved Jean Grey, at his own claws, the mutant Logan is plagued by nightmares and self doubt. But Logan cannot hide from the world forever. A young woman named Yukio locates him in the Yukon convincing him to return with her to Japan to say goodbye to a dying friend from long ago. That friend is Master Yashida, a man Logan saved from the bombing of … Continue reading


text: I Will Kill You! Flag By: fluffman (More by author: Most viewed, Newest, Most Thumbs) previous next random - Fav + Fav Comment not mine but made me lol and dwaaah Tags: the | night | be | Mad Recommend tagsx +1331 Views: 44263 Favorited: 135 Submitted: 11/12/2012 Share On Facebook Remove from favorites Add to favorites Unsubscribe from fluffman Subscribe to fluffman So I see you're using adblock. This site costs a lot of money and time to run. It's also in danger of shutting down since everyone uses adblock and ads used to pay the bills. You can donate here or just post some content so we get new visitors from google (who don't use adblock).


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NEW YORK (MarketWatch) -- J.C. Penney Co. JCP, -0.26% in response to speculation that Chief Executive Ron Johnson is stepping down, said on Tuesday that Johnson isn't resigning. "The rumor is false," spokesman Joseph Thomas told MarketWatch. Penney shares fell back to a gain of 1.6% after the stock had jumped as much as 4.3% on rumors of Johnson's leaving the struggling retailer
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text: gallery Vegetarian Pizza Recipes You don't need to be a vegetarian to love these pizzas topped with all kinds of cheeses -- including mozzarella, ricotta, Parmesan, Pecorino Romano, Gruyere, and Havarti -- and vegetables galore, such as tomatoes, zucchini, eggplant, mushrooms, potatoes, and even butternut squash. Pizzas can be made with from-scratch crust when you have the time, or with store-bought dough on busy nights. sharePinterestFacebookTwitterGoogle+ Email


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This article was previously published under Q150800
NoticeThis article applies to Windows 2000. Support for Windows 2000 ends on July 13, 2010. The Windows 2000 End-of-Support Solution Center
(http://support.microsoft.com/?scid=http%3a%2f%2fsupport.microsoft.com%2fwin2000)is a starting point for planning your migration strategy from Windows 2000. For more information see the Microsoft Support Lifecycle Policy
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In TCP/IP-based networks involving routers and multiple segments, it is generally recommended that you implement WINS for name resolution and browsing support. However, as an alternative to WINS, it is possible to have full domain browsing by using only LMHOSTS files on all computers, although there are some limitations that will be discussed in this article.
In either case, it is important to note that a client only participates in domain browsing when the client is using a workgroup name that is equivalent to the domain name (WorkgroupName = DomainName). Windows NT computers can also "join" the domain to gain this functionality, instead of being in a workgroup.
This functionality of LMHOSTS-based domain browsing (over routers) has not been formally documented or tested by Microsoft, and may not be available in future versions of the client and server operating systems. Use this information with discretion.
"Browsing" in a Microsoft network should be considered a distributed service provided by one or more computers. Each computer can fall into several browser roles; however, this article focuses on the two most important ones:
For more information, please see the following article in the Microsoft Knowledge Base:
102878In order for this distributed browse service to work, the SegMBs need a way to determine exactly who the DomMB is. They can determine this by locating the computer that has registered the NetBIOS name "Domain<1b>", because that is only registered by the PDC (which also is the DomMB, as noted above).
(http://support.microsoft.com/kb/102878/EN-US/ )Information on Browser Operation
For more information, please see the following article in the Microsoft Knowledge Base:
(http://support.microsoft.com/kb/119495/EN-US/ )List of Names Registered with WINS Service
Domain Browsing with WINSIn a WINS environment, a SegMB would query WINS to determine who registered Domain<1b>. In this case WINS acts as a convenient central resource for this information. There is one more benefit in having WINS to assist browsing: multi-domain browsing.
Multi-Domain Browsing with WINSA PDC that is set up to query WINS periodically requests the list of all domains that are registered in the database. (A domain is identified by a "Domain<1b>" registration in the database, and the associated IP address of the PDC that registered it.) The PDC combines this with its own domain browse list, and thus has a complete list of computers in its domain, as well as a list of other domains, all across the WAN. When the PDC then interacts with its SegMB's, it gives them this complete list. You then see the effect of this when you browse the network using File Manager or Network Neighborhood.
NOTE: That is the extent of WINS involvement with browsing. It is not involved in the browser election process, nor with helping a client determine who its local segment master browser is, nor with helping the DomMB determine who the SegMBs are; that is done in the process when the SegMB first contacts the DomMB.
In certain networks it may not be valuable to use WINS; this can only be determined on a case-by-case basis. You can then use either LMHOSTS or DNS to resolve computer names; however, LMHOSTS are required for domain browsing, as well as other domain management issues such as database replication and domain secure channels.
Domain Browsing with LMHOSTSWithout WINS, you need special LMHOSTS entries that designate who all the domain controllers are. This is done in the following convention:
When a computer is booted, it reads these entries and store them permanently in the NetBIOS name cache until the computer is powered down. (Because of this, it is best that these entries are last in the LMHOSTS file, for subsequent LMHOSTS parsing efficiency.) All computers in the domain needs one of these entries for each domain controller (in the local domain), as well as one for the PDC. Also note the exact order of #PRE #DOM, and that they are capitalized. The other names are not case sensitive.
18.104.22.168 ComputerName #PRE #DOM:DomainName
Windows NT Segment Master BrowsersHaving the above entries is sufficient for a Windows NT computer: Upon becoming a Segment Master Browser, a Windows NT computer determines who the PDC is by sending a query (using the NetGetDcName API) to all LMHOSTS entries with the #DOM:<localdomain> designation. Only the PDC responds. The Windows NT computer then contacts the PDC, informs the PDC that it is a master browser, then continues the process of getting the domain browse list. The PDC then contacts the Windows NT computer to get its local segment browse list. This process repeats every 12 to 15 minutes.
Windows 95 and Windows for Workgroups Segment Master BrowsersThese do not perform the NetGetDcName API, so they need entries in the LMHOSTS file that indicate who the PDC is. Assuming the example above is the PDC of the domain, you would have two entries for a Windows 95 or Windows for Workgroups client:
The first entry allows the PDC to act as a logon domain controller for the client, the second entry allows the client browser service to explicitly find the PDC. Remember you will probably have multiple lines similar to the first line (for multiple domain controllers), but only one line with the \0x1b directive (to designate the PDC). Note that the domain name must be in quotes, and padded with spaces for a total of 15 characters before the \0x1b portion. (The example above shows commas for visual placeholders, however in a real LMHOSTS file these commas would be replaced with spaces). Also be aware that moving the PDC role to another Windows NT Server (via promotion) will cause your \0x1b entry to be invalid. Options to fix this:
184.108.40.206 controller1 #PRE #DOM:domainname 22.214.171.124 "domainname,,,,,\0x1b" #PRE
Note About NetBIOS NamesEvery NetBIOS name is a full 16 characters in length; the first 15 are user definable (or padded with spaces), and the 16th character is reserved to identify the network service that registered the name. The most familiar example of a NetBIOS name is the ComputerName on any Microsoft networking client. When the client is booted, various client network services will register the ComputerName along with their unique extension, such as ComputerName<00> (workstation service), and ComputerName<20> (server service). In this case, the only difference between these two names is the 16th character - and that does make them individually identifiable. A client can register all of its names by broadcast, and by direct datagram to WINS, depending on the client node type. Other companies may also register NetBIOS extensions that are not reserved by Microsoft.
For more information, please see the following articles in the Microsoft Knowledge Base:
(http://support.microsoft.com/kb/119493/EN-US/ )NetBIOS over TCP/IP Name Resolution and WINS
(http://support.microsoft.com/kb/119495/EN-US/ )List of Names Registered with WINS Service
LMHOSTS ExampleYour domain name is "Globe", your PDC NetBIOS name is "Mongo", and you have other various backup domain controllers. Your LMHOSTS file would look like this:
To verify that you've entered these correctly, open a command window (DOS prompt) and look at your NetBIOS cache:
184.108.40.206 "globe \0x1b" #PRE 184.108.40.206 mongo #PRE #DOM:globe 188.8.131.52 otherdc1 #PRE #DOM:globe 22.214.171.124 otherdc2 #PRE #DOM:globe
TIP: the <1B> entry will not show up if you do not have exactly 15 characters in the name, or if you do not use quotes, or if you enter the forward slash "/0x1b" (as opposed to "\0x1b").
c:\> nbtstat -c NetBIOS Remote Cache Name Table Name Type Host Address Life [sec] ------------------------------------------------------------ globe <1B> UNIQUE 188.8.131.52 -1 MONGO <03> UNIQUE 184.108.40.206 -1 MONGO <00> UNIQUE 126.96.36.199 -1 MONGO <20> UNIQUE 22.214.171.124 -1 OTHERDC1 <03> UNIQUE 188.8.131.52 -1 OTHERDC1 <00> UNIQUE 184.108.40.206 -1 OTHERDC1 <20> UNIQUE 18.104.22.168 -1 OTHERDC2 <03> UNIQUE 188.8.131.52 -1 OTHERDC2 <00> UNIQUE 220.127.116.11 -1 OTHERDC2 <20> UNIQUE 220.127.116.11 -1
Multi-Domain Browsing with LMHOSTSIt is important to note that the main drawback to LMHOSTS browsing is that it does not provide the automatic ability of multi-domain browsing. As previously mentioned, the PDC will query WINS for a list of remote domains and include that information in its browse list. However, the PDC will not parse the LMHOSTS file for the same information, nor will it include other \0x1b entries with the #PRE (cache) directive. Effectively, if your PDC does not query WINS, you will not see other domains through File Manager or Network Neighborhood. However, you can still browse other domains manually, (provided that you know the domain name and that you have special entries in your LMHOSTS file), and there is still a chance that you may browse remote domains based on broadcasts.
Manual Method: this is accomplished by including a \0x1b entry for the PDC of any remote domain you want to browse. This technique applies to Windows NT, Windows 95, and Windows for Workgroups. It is effective because of the following sequence of events, necessary for remote domain browsing:
For WinNT computers: c:\net view /domain:<domainname>Broadcast Method: This works in the case of any network segment that has members of multiple domains. There is a SegMB of each domain on the "mutual" segment, and each SegMB announces its domain via broadcast to a special NetBIOS name <01><02>_MSBROWSE_<02><01>. This broadcast packet includes the domain name and the computer name of the SegMB that announced it.
For Win95 and WFW: c:\net view /workgroup:<domainname>
The SegMBs of other domains (on this mutual segment) listen for this information, and add it to their local browse list. A SegMB on this segment has now "discovered" other domains, and send the discovered information to: the DomMB of his domain, and to local clients (in his domain) that request a browse list.
A client requests the local domain browse list (from a local SegMB) and see the discovered domains in File Manager and Network Neighborhood. When the client selects the discovered domain, he actually requests a browse list directly from the SegMB that made the announcement in the <01><02>_MSBROWSE_<02><01> packet. Furthermore, since this information was also sent to the client's DomMB, it is propagated to SegMB's on other segments that are part of this domain.
Clients on a remote segment can now leverage this information, and browse the remote domain even though there is no remote domain member on their segment. However, this process is very volatile using LMHOSTS files, because you are dependent on the "discovered remote SegMB's" still being active. In a WINS environment, this remote browsing feature is much more stable because WINS provides information about the remote domains to your PDC.
Things to consider:
Article ID: 150800 - Last Review: February 22, 2007 - Revision: 3.3
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Taye Diggs and wife Idina Menzel Welcome A Baby Boy
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The Hollywood stork has been working overtime this summer, and Taye Diggs is the latest star to be visited by the baby-bearing bird this season.
Diggs' wife, actress Idina Menzel, gave birth to their son Walker on Wednesday. Their reps confirmed to People magazine that, "Mother, father and son are all doing well."
This is the first child for the couple, who first met in 1996 while performing as part of the Broadway musical "Rent." The 38-year-olds were married in 2003.
Diggs can currently be seen on the small screen in the show "Private Practice."
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Just say'in #2
Use to see on older sago's in the past, suckers not only sprouting from the base of the trunk but also about half way up out of the trunk itself, proud to say we've joined the big boys, ours are too!!! lol
From the post about SP not producing multitudes of seeds from time to time, our serenoa is the same way, seeds galore one year but the year after or so.......next pic
Just a few & thats it!!
On the other hand, our windmills are prolific producers.
It's been cool enough to sit out on the pier the last couple of days between rain showers.
How bout some blackeyed peas w/ham jiblets & rice & fresh green onions & of course southern tea to wash the baked corn bread down!!! lol Brad I havn't been hang'in round the other board lately but went on & checked out your last post, man, you have got a nice thing go'in there & that landscap'in job is absolute eye candy, great job my friend!! Thanks
Lookin great man. Been trying to move down your way, but it doesn't look likely. I drink a lot of tea daily myself, but I prefer it unsweet, I'm fat enough already! You better kiss your wife cuz I know you didn't cook that. Love that Southern food. I miss NC every time I leave!


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After School, a South Korean girl group, is the first to introduce an orderly system for admitting and "graduating" members from the group. It has enjoyed tremendous popularity and has had numerous hit songs in both Korea and Japan since its debut in 2009. The nine members of the group are Park Kahi, Kim Jung Ah, Lee Joo Yeon, Uee, Raina, Nana, Lizzy, E-Young and Kaeun. Watch the music videos of their songs, including "Let's Do It," Because of You, "Diva," "Love Love Love" and Play Ur Love".


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Comic Strip ConversationsPaperback
List price $12.72
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- Publisher: Future Horizons Incorporated
- Format: Paperback | 39 pages
- Dimensions: 206mm x 268mm x 6mm | 181g
- Publication date: 1 June 1994
- Publication City/Country: Arlington
- Edition statement: Revised and Updated ed.
- Sales rank: 14,976
Product description
Carol Gray combines stick-figures with conversation symbols to illustrate what people say and think during conversations. Showing what people are thinking reinforces that others have independent thoughts - a concept spectrum children don't intuitively understand. Children can also recognize that, although people say one thing, they may think something quite different - another concept foreign to concrete-thinking children. Children can draw their own comic strips to show what they are thinking and feeling about events or people. Different colors can represent different states of mind. These deceptively simple comic strips can reveal as well as convey quite a lot of substantive information. The author delves into topics such as: What is a Comic Strip Conversation?The Comic Strip Symbols DictionaryDrawing small talkDrawing about a given situationDrawing about an upcoming situationFeelings and COLOR
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Author information
Carol Gray has over twenty years of experience educating students with Autism Spectrum Disorders (ASD). Carol initiated the use of Social Stories in 1991 and has written numerous articles, chapters, and books on the subject. She is a sought-after speaker in the United States and abroad. Carol is the director of The Gray Center for Social Learning and Understanding, a non-profit organization that serves people with ASD, and currently works privately with students, parents, and professionals in a variety of educational and vocational settings.


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I'm an enthusiastic basketball fan roughly 3% of the year. Usually this 3% falls within…
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Something has come up repeatedly in this week's prayer. I wonder if it's something that…
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At the beginning of a New Year, we can turn to the words of Pope Francis' Evangelii Gaudium (Joy of the Gospel) for inspiration as we tighten up our commitments, forge into new territory, and pray together for lives filled with joy — of all kinds — in 2014.
Resolution #1: Be Joyful
Obviously this is at the heart of the papal message in Evangelii Gaudium, and something Pope Francis professes himself. It's not always easy to be joyful, especially when we are in physical pain or when someone hurts our feelings. But Francis reminds us that:
The joy of the gospel fills the hearts and lives of all who encounter Jesus. Those who accept his offer of salvation are set free from sin, sorrow, inner emptiness and loneliness.…
This smacks of placing limitations on one's holiness. God does not place an imaginary line that rates how holy we are on us. Rather holiness is a more all-encompassing term. Asking this question suggests that one would like to sin "just enough" to know how bad they could be without spilling into hell.
An adult sense of faith places us into a new sense of relationship with God. This relationship requires participation on our part where we place ourselves in our human weakness before God and humble ourselves in that presence. It's not about how holy we can be, it's about always trying to be as holy as we can be.…
I commit the same sins over and over and I feel bad going to confession when it is most likely I will commit the same sin. How do I say I will not sin again when I feel inside I will sin again? Am I using confession as a excuse to sin knowing I can confess and be forgiven?
All of us have weaknesses and our sins are consequences of that. No one is perfect, and usually many of our sins are things that continue to trip us up time and time again.
That said, while we have this tendency toward some particular sin, we also need to attempt to get over this. Our efforts here must be true attempts to get past our sin, to get underneath the tendency, and to make a true attempt to stop the behavior.
Again, none of this is easy and therefore we have confession…
My fiancé and I would like to get married in Italy through the church and are taking all the courses need to do so through the catholic church here in the U.S. Since we would be excluding many family members and friends by having a ceremony it Italy we wanted to come back to the U.S and a month later have a civil ceremony is that possible? The lady at our church said it wasn't because in the churches eyes it "belittles" the sacrament. So my question is can i get married through the catholic church in italy then come and have a civil ceremony in the U.S without the church knowing or having to file in any way my civil marriage?
This question asks a few things to consider. But mostly, it asks about the celebration…
Technically speaking, a priest or a deacon is only supposed to bless anything and certainly would be the only ones to use holy water in a formal blessing. However, informally we bless one another all the time. For instance, when someone sneezes the typical response is "God bless you."
Many people have holy water fonts in their homes, usually on their doorframe. We all bless ourselves when we enter a church by dipping our fingers in the holy water font. Perhaps a good idea is for husbands and wives to dip their fingers in together at home or church and create a formal ritual that way.
Here's one prayer for husbands to pray for their wives:
Lord, our God, bless _________ as my wife. Grant her the grace…
I'm tempted to ask whether you mean for God or for us?
God hears all prayers and the intention of simply praying is enough for those prayers to be brought to God. The use of the word "heard" however, describes God as a type of divine "Santa Claus".
Prayer is simply communication with God. However, prayer doesn't change God…prayer is meant to change US. Our communication with God isn't some kind of divine wish list, instead it is an opportunity to grow closer with God, to understand where God might be working in our lives and what God might be asking of us.
Prayer is also a reminder for us. That reminder is that we are not in control and so, we stand before God in awe of what…
God forgives all sins. So there's no need to worry about that. The question might be whether this was even a sin. Your husband may have not had intended to kill the person in this encounter and instead acted if self-defense. For something to be sinful, one has to have intent to commit the act and have full knowledge that the act is sinful and then, has to actually carry it out.
In this instance, let's say your husband had every intention of finding an enemy and killing them. That indeed would be sinful. A good confession would be appropriate (and healthy) for him to share much of the horror of war with God and to ask for forgiveness in his part in the war. War may be necessary and one might be following orders, but…
St. Francis: Your Holiness, it's so nice to see you!
Pope Francis: We can cut the formalities. After all, I took your name!
St. Francis: True, Jorge, true. I was honored but then I got jealous thinking you'll be the more famous Francis.
Pope Francis: Ignatius of Loyola must be giving you a lot of grief!
St. Francis: Nope, but he lost a bundle! He bet that you were going to take his name after you were announced. I gave him 3-1 odds that it wouldn't be "Ignatius."
Pope Francis: Ouch! He's gonna give me a lot of heartache for that one. Since I'm a Jesuit and all.
St. Francis: The fact is that you're giving him a lot of good press. And you're doing a swell job!
Pope Francis:… Thanks, thanks. It's not easy. Do you
Jesuit Antonio Spadaro, S.J., editor of the Italian La Civiltà Cattolica, has created a masterpiece of an interview with Pope Francis, cobbled together from questions from 16 Jesuit journals, including America… magazine here in the United States.
What's the takeaway for young adults? In this initial reflection, I'm going to share my thoughts on that question. Later, and as we continue to see Pope Francis in action, I'll reflect more deeply on the issues he's covered in the interview. For now, my thought is that synthesis makes for easier reading.
Be a humble sinner
The interview starts with a simple question and a short answer: "Who is Jorge Mario Bergoglio?" (Pope Francis' given name) and his
Recently, a former student came to me for advice about dealing with a group of people who didn't share the Church's ideas on a variety of subjects. I thought immediately of what Pope Francis might say.
I noted to the student that relationships take work. And many times we will encounter people in the world who do not share our beliefs. Our goal is not to be dismissive, but rather to stay in relationship with these people anyway. To dismiss them would sever the possibility of relationship. I also noted the words of Jesus in Matthew's gospel: "If anyone will not welcome you or listen to your words, leave that home or town and shake the dust off your feet."
Too often people use these words…
Question: I was 18 when I married my first husband. The local priest would not let us have the ceremony in the church because I was pregnant. He performed it in the rectory. Is it a Church rule that you cannot marry in the church building if you are pregnant?…
It is not. I'm going to assume that the wedding was also small and intimate. Your priest was most likely embarrassed by your pregnancy (or angered by it) and did not want to have the wedding in a more public setting. Likely, he saw this as a failing of his own in having one of his parishioners pregnant out of wedlock.
But let's not assume, perhaps he had good reason to have the wedding in the rectory. To your question, there is no hard and fast rule about where the
Question: A Catholic born in the Church grows up, and during their lifetime, they want to start a Marriage Officiant business. Not interested in giving the sacraments, they decide to join a well known ministry that ordains non-denominational ministers. Our Catholic then creates a wedding business that does not incorporate the Eucharist since this is an Ordained Priest's duties. Years later, someone from the Church finds out, and now our Catholic is probably facing Excommunication for starting the business. Can this Catholic be excommunicated for becoming an ordained minister in this business?…
The answer is, as most answers are, "it depends!"
The first thing to point out is that excommunication
"I appeal strongly for peace, an appeal which arises from the deep within me. How much suffering, how much devastation, how much pain has the use of arms carried in its wake in that martyred country, especially among civilians and the unarmed! I think of many children will not see the light of the future! With utmost firmness I condemn the use of chemical weapons: I tell you that those terrible images from recent days are burned into my mind and heart." — Pope Francis…
With the recent revelations that chemical weapons have been used in Syria's civil war, the United States has been clear about how seriously it takes these human rights violations. Over the weekend, Secretary of State John Kerry reported that
Labor Day is upon us, and recent college grads are entering the workforce for the first time. However, far too many young adults are unemployed, unable to find a suitable job, much less a career. For many more, their current jobs don't exactly match up with their idea of a "dream job," and scores of others are underemployed (overqualified for their position) but need to work to pay the bills.
In my work as a spiritual director, I often specialize in helping people find meaningful work. I spend time helping young adults find where they believe God may be calling them and then help them take some proactive steps to put those desires into a practical career path. At the very least, I work with young adults to articulate…
No. If that were the case all of our priests and religious women would be "bad."
I sense that what you may be asking might fall under a few different categories:
1) A single person who wishes not to marry.
2) A married person who simply doesn't want to have children.
The first part enables me to talk about the vocation to the single life. Some people do not feel called to be married. They are typically fine with being single and live lives of holiness in doing so. If they never marry nor have children they are not doing anything sinful.
The second situation is more complex. One of the requirements to be married in the Church is to be "open to the procreation of children" meaning that we don't…
Question: My family has always wondered about the case of non-Christians who celebrate Christmas. Over the years, we've known many atheists who decorate trees and exchange presents, either "just for fun" or so their kids don't feel like they're "missing out." On one hand, I feel like Jesus would be happy that they're being loving towards each other no matter what the reason. On the other hand, it's a little irritating to me. Does the Church have a position on this? And does it matter that they are copying non-religious aspects of the holidays, like Christmas trees and Easter bunnies?
The interesting thing to note is that the rituals surrounding the…
Question: My son is planning a wedding next summer, he was raised Catholic but stopped attending Church after HS, his bride attended the Presbyterian Church, neither have attended Church in the past 5 years, they are planning to have a nondenominational minister officiate their wedding. I have been encouraging them to attend PreCanna classes, they are "too busy" work and college classes. they also are having an outdoor ceremony at a resort. Is there any chance they could have a Catholic Priest officiate ?
The short answer is probably not. They would, at minimum, need to go through marriage preparation in the Catholic church and then file for a dispensation from place to the local bishop who would…
Security at World Youth Day has always been an issue. When millions of people gather for a public event, in general, security can be a challenge. Add to this the fact that the pope will be on the scene and the concerns about safety grow drastically.
But Pope Francis doesn't seem to be very concerned about security at all. On the streets of Rio de Janeiro, he appeared to relish in the fact that his car made a wrong turn and people mobbed the vehicle to try to touch him or just get a glimpse of him.
After a week of what could be a draining non-stop schedule of events, Pope Francis, in his late 70s, was fed by the energy of the young people who surrounded him:
This trip has been very good; spiritually, it has done me good … meeting…
Pope Francis said that he doesn't give interviews.
But that all changed on the plane ride back from World Youth Day where for nearly 90 minutes the pope stood and didn't dodge a question from anybody.
You can read John Allen's summary of the impromptu press conference here.
Pope Francis mentioned the following with regard to the gay lobby that supposedly exists within the Vatican and that reportedly he acknowledged exists:
When I meet a gay person, I have to distinguish between their being gay and being part of a lobby. If they accept the Lord and have good will, who am I to judge them? They shouldn't be marginalized. The tendency [to homosexuality] is not the problem … they're our brothers.
The question…
I've been to two World Youth Day events and they were indeed spectacles. I even dedicated an entire chapter to World Youth Day in my first book, Googling God. These pilgrimages that bring youth and young adults together from all over the world were the brainchild of John Paul II and will probably be what he will be remembered most for as pope. He wanted to bring college students together for a "jamboree style campout" with the pope at the helm. The result was a Pope-as-Rock-Star event that brought hundreds of thousands of young people together from around the globe.
But there is a huge downside to World Youth Day. It costs A LOT of money — for the host diocese to produce and for the individual pilgrim to attend.…


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What does one gain from an extended biol time ???
Grinders Island Brewery - Pipeline
Bottled! Award winning East India Porter, Oatmeal Stout, Milk Stout, Saison fermenting at a nice controlled 85 degrees (up from 70) as it should be - weird isn't it.
Reduction of volume. Carmelization of sugars. Greater hop utilization. More time to relax with a good cigar and a homebrew while you enjoy the wonderful aroma of boiling wort.
Reality is a crutch for people who can't cope with drugs. -Lily Tomlin
Melanoidin flavors, a little more bitterness from your bittering hops (if they are boiled the whole time), a lot less flavor/aroma from your bittering hops (useful if making, say, a scotch ale where hop flavor/aroma are undesired)
also reduces dimethyl sulfide (DMS), the smell you get from canned corn- good to reduce this in light pilseners
also, i often end up using more mash/sparge water than i wanted due to temperature adjustment, so its useful in hitting your target gravity- if the gravity is too low, just keep boiling!
So that you can boil off more wort?
I usually boil until I'm at 6 gallons, the add my 60 minute hops and start timing. You can get a few more IBUs out of boiling them for as long as 75 minutes, but not much.
The only time I plan on a 90 minute boil are when one of two things is true:
1. Using pilsner malt. If I'm using pilsner malt, everything I've read says to do a 90 minute boil to boil off more DMS. I don't know if this is always needed, but it's what I do.
2. In a bigger beer, my efficiency decreases quite a bit (and it's not great as it is) so I'll do a longer boil and try to increase my sparge runnings. This works well, because I'm using more grain and should actually use more sparge water as a result. So, I'll sparge more and boil longer to get closer to my intended OG.
I have this feeling we've discussed this before.
OH YA...>WE DID.....IN YOUR THREAD WITH THE SAME ****ING NAME!http://www.homebrewtalk.com/search.php?searchid=2587197
and one day before that...someone else asked it....here:http://www.homebrewtalk.com/f14/90mi...in-boil-87058/
Maybe a mod could combine all of these or something...just so you don't get confused and start yet another.
Well - I searched and found nothing. I even searched 60 vs. 90 minute boil and found nothing - get off your high horse again BIG.
Seriously - get over it and deal with it.
I SWEAR Yoop - he just waits for me to mess up - I'm glad he is the cop here!! Good God!


text:
hugin 2010.4.0+dfsg-1 source package in Ubuntu
hugin (2010.4.0+dfsg-1) experimental; urgency=low * Drop Cyril Brulebois from Uploaders. Thank you very much for your work. * Bump package version. (rc3 was re-released as 2010.4.0). hugin (2010.4.0+dfsg~rc3-1) experimental; urgency=low * New upstream version. * Use debhelper v7. hugin (2010.4.0+dfsg~rc1-1) experimental; urgency=low * New upstream version. hugin (2010.4.0+dfsg~beta2-1) experimental; urgency=low * New upstream version. * Drop patches included upstream: 51_initializecp-prefs.diff, 52_build_on_kFreeBSD * Unfuzz 45_autopano-noop.sh_withoutshextension. * [debian/copyright] Refresh list of upstream authors from authors.txt. * Invoke dh_makeshlibs with --noscripts option to get rid of lintian warnings post(inst|rm)-has-useless-call-to-ldconfig. (The program is still necessary to make dh_shlibdeps aware of the private libraries without fiddling). hugin (2010.4.0+dfsg~beta1-2) experimental; urgency=low * [52_build_on_kFreeBSD] Should fix building on GNU/kFreeBSD. * Amend package descriptions, adding missing tools and sorting the list. (Thanks, Yuval Levy) hugin (2010.4.0+dfsg~beta1-1) experimental; urgency=low * New upstream version. * Update build-depends, adding multiple newly required boost modules. * Drop 20_invalidexiforientation.patch, included upstream. * Refresh patches. * Install newly available binaries and manpages (checkpto, cpfind and icpfind). * Drop unused lintian overrides, private shared libraries are not installed in /usr/lib anymore. * [51_initializecp-prefs.diff] Pulled from upstream HG. Correctly initialize list of cp-detectors on fresh installs. See https://bugs.launchpad.net/hugin/+bug/682099 * Minor updates for debian/rules. * debian/control: Fix nona description. Its main purpose is remapping, not stitching. * Add menu entry for PTBatcherGUI. hugin (2010.2.0+dfsg~rc2-2) experimental; urgency=low * [20_invalidexiforientation.patch, pulled from upstream HG] Fix crash on loading images with invalid (empty but existing) Exif orientation tag. * Reorder suggests to prefer autopano-sift-c over autopano-sift. Install time defaults are set up for autopano-sift-c. Closes: #405862 * Remove Florent Bayle from Uploaders. Thank you for your work. Closes: #554062 * Improve on short package descriptions. Closes: #603768 -- Yuv <email address hidden> Tue, 01 Feb 2011 11:17:54 +0000
Upload details
- Uploaded by:
- Yuv on 2011-02-01
- Uploaded to:
- Natty
- Original maintainer:
- Debian PhotoTools Maintainers
- Component:
- universe
- Architectures:
- any
- Section:
- graphics
- Urgency:
- Low Urgency
See full publishing history Publishing
|MD5 Checksum
|11.8 MiB
|31.1 KiB
|1.6 KiB
Available diffs
Binary packages built by this source
- hugin: panorama photo stitcher - GUI tools
Hugin is a panorama photo stitching program. Essentially, Hugin is a
GUI frontend for Panorama Tools. Stitching is accomplished by using
several overlapping photos taken from the same location, and using
control points to align and transform the photos so that they can be
blended together to form a larger image. Hugin allows for the easy
creation of control points between two images, optimization of the
image transforms, and much more.
This package includes the following graphical interfaces, using the
command-line tools provided in the hugin-tools package:
* hugin - Hugin panorama creator.
* hugin_stitch_
project - Hugin batch stitcher.
* nona_gui - Graphical interface for nona.
* PTBatcherGUI - Batch controller for the stitching process.
- hugin-data: panorama photo stitcher - common data files
Hugin is a panorama photo stitching program.
This package includes the data files needed by the hugin and
hugin-tools packages.
- hugin-tools: panorama photo stitcher - commandline tools
Hugin is a panorama photo stitching program.
This package includes command-line tools used by hugin and other
packages for image stitching and High Dynamic Range (HDR) images:
* align_image_stack - Align overlapping images for HDR creation.
* autooptimiser - Optimize image positions.
* calibrate_lens - Lens calibration tool.
* celeste_standalone - Remove cloud-like control points.
* cpclean - Remove wrong control points.
* cpfind - Patent-free control-point detector
* deghosting_mask - Creates mask for removing ghosting in images.
* fulla - Correct lens distortion, vignetting, and
chromatic aberration.
* hugin_hdrmerge - Merge overlapping images.
* icpfind - Control-point detector wrapper program.
* matchpoint - Run feature detection and extraction.
* nona - Remap images. (Also does simple stitching.)
* pano_modify - Change output parameters of project file.
* pto2mk - Create a makefile for stitching.
* pto_merge - Merges two or more Hugin project files.
* tca_correct - Calculate transverse chromatic aberration.
* vig_optimize - Determine the radial vignetting.


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text:
Post Category → Clinique
Clinique Gift With Purchase + Jenna Menard Appearance Macy's Heralnd Square
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NEW: Clinique Dramatically Different Moisturizing Lotion +
For me, the iconic Clinique Dramatically Different Moisturizing Lotion (known as DDML to its cult members) is almost like a FRIEND of mine, like Sassy magazine, Judy Blume novels and My Two Dads. =&3=& with a 50% improvement in moisture for all-day hydration without a single drop fo oil and 54% improvement in skin's barrier strength in 8 weeks without changing its famously silky texture. It now includes skin care MVP hyaluronic acid, in addition to glycerin and urea. =&4=&
New: Clinique Chubby Stick Intense
Clinique Partners With Tracy Reese On Limited Edition Cosmetics Bag
Everyone loves a gift with purchase–and Clinique's GWPs were for me, a total gateway drug into the world of cosmetic excess. The legendary brand has partnered with Tracy Reese for the third time on a limited edition Tracy Reese for Clinique cosmetics bag.
This ultra-feminine cosmetics bag holds must-have beauty essentials to achieve healthy skin and a flawless, fall makeup look: Dramatically Different Moisturizing Lotion, 7 Day Scrub, Even Better Makeup Broad Spectrum SPF 15(choice from 4 shades), a compact featuring Colour Surge Eye Shadow Duo in Like Mink and Blushing Blush in Cupid, Long Last Lipstick in Merlot, High Lengths Mascara and a perfectly portable size of Happy Fragrance.
The complimentary, Tracy Reese for Clinique cosmetics bag is available with any Clinique purchase of $28.00 or more and has an $80.00 value. It's available exclusively at Nordstrom and Nordstrom.com from October 30 through November 11.
Do you love a Clinique GWP?
Cool Products For Hades Climes
|I just want my products to induce the same cool, calming effect as
Blanche Devereaux's wallpaper. I'm a deeply tropical PERSON. Is that too much to ask?
For a summer that's felt like August the entire time, believe me when I say I'm nervous about the real August. I'm so HOT all the TIME that I've been stockpiling all my cooling bath, body and hair products like a heated hoarder. Here, my all-time faves of the bunch.
Clinique Even Better Eyes ($40) Got Beetlejuice undereye circles? Clinique's got you covered with this new formula boasting a cooling tip applicator. It's clinically proven to visibly reduce dark circles by 30% in 12 weeks and imparts a soft-focus finish thanks to its fleshtone iridescent formula.
Coral Obligation: Three Vibrant Coral Lip Accoutrements For Spring
|The REAL coral.
The shade you need to rock nonstop this spring? Vibrant CORAL. Coral is the best way to channel a retro lip moment when red is just too much for warmer weather. And you KNOW it'll be migrating all over your cheek by end of day in steamy climes. Coral is fresh, coral is lighter, coral is giving me LIFE–in these three iterations. Here's your spring Coral Obligation.
Clinique Long Last Lipstick in Runway Coral This hot hue was created by Clinique Global Color Artist Jenna Menard and will launch (limited edition) in May for $15 at clinique.com. It boasts buttery texture and a hot coral hue–skewing more red than salmon. It's so retro in a formerly thin Mad Men's Betty Francis way, that I feel as if we were to give it to her, she'd stop eating her feelings. It's that good. Coral sex, if you will.
Clinique Introduces SEVEN New Almost Lipstick Shades
|Credit: Clinique
Clinique is truly like that '80s band who introduces new hits all the time–but will always give the crowd what it wants–their original favorites in their original glory. Case in point? The brand's EPIC Almost Lipstick franchise, slim lip hydrators boasting a bit of shine, a smidge of stain, a naughtily natural color–now available in seven new shades, each spun off of the original Black Honey.
It's like BH is the "Three's Company" to seven new "The Ropers" moments. I'm super into it. My fave is the Luscious Honey, a supremely wearable sheer pinked-off red. Here's the full lineup of shades.
Holiday Gift Guide: Merry Clinique Gift Sets
Sparkle, Neely, sparkle: This is the 2011 BBJ Holiday Gift Guide. For more gift-worthy items for everyone on your list, check out my other offerings.
Clinique has a special place in my heart because it was one of my original favorite beauty brands. Their GWPs got me through many a bad day in high school. You know how I feel about their Superbalms and their Chubby Stick Moisturizing Lip Colour Balms (THEY ARE EVERYTHING). And now, you can score little beauty poo poo platter samplers of both within Clinique's Merry Clinique Gift Sets, each going for a wallet-friendly $39. Bright, gorge shades, incredibly luxe texture and fantastic variety–who wouldn't want to be on the receiving end? Let's take a little look at these gifts, mmkay?
Lips To Go Set
The lipsticks and lip glosses in this set can be mixed and matched to create the perfect pout for any occasions, be it dinner with friends or an office Christmas party.
Don't Call It A Comeback: Prescriptives Is Back
Remember way back in 2009 when Prescriptives sadly closed its counters? In a very The Vampire Diaries way (seriously, everyone gets stabbed on that show and no one ever dies), it's back in action online only at prescriptives.com. And I couldn't be more elated. Read on…
There's a special place in my heart for the amazing range featuring custom blends (which you can get if you still have your formulas, by the by). Prescriptives was my first foray into department store brands after dipping my toe into Clinique after years and years of Bonne Bell. My first lipstick EVER was one of their purple ones for my semi-formal in 1995. It matched perfectly my hideous satin Zum Zum dress. I always loved starting conversations about my Prescriptives lipstick with "Medically speaking…" as I'd decided the word Prescriptives sounded too medical not to capitalize on that. I also knew it'd be the only time in my life I'd start any sentence with "medically speaking."


text:
solar carriage lights
I'm looking for some carriage lights for the outside of my garage and was hoping to find some solar ones. I've searched all over the internet and have found plenty of solar post lighting and garden lights, but nothing for mounting on my garage. Anyone know where to find those? I know I can't be the only person who wants them. Thanks!
I suppose most garages are wired, so manufacturers might not see a lot of call for such a product. What I've seen has been "shed lights" with PV supplies, but they're not what anyone would call stylish.
You might "roll your own." A good PV supplier ought to be able to supply a small battery-based system. Add off-the-shelf fixtures that you like, and fit them with 12 volt compact fluorescent or LED lights (also available from many PV dealers).
Below is a link to a page with some examples of small PV systems. In addition to what's listed there you would need a 12 volt deep cycle battery. I'd recommend an East Penn gel battery (just because they've given me excellent service). It makes sense to source the battery locally as it's a heavy item.
(I have no connection with this company and in fact have never traded with them, they just happened to be in my bookmarks related to solar energy.)
For example, if you want to operate two 5 watt CFs for up to 16 hours of darkness, you'd need 160Wh of energy. A 26-30 amp hour battery would supply this at no more than 50% discharge (makes it last a long time). A larger battery, say perhaps an 8G22 (group 22, 50 amp hours) would give you some extra "flex" for long strings of cloudy days.
Then you'd need a PV system which can produce this amount of energy on the minimum average insolation your area receives. For example, if you can count on an average of 3 hours of full daily sunshine on the shortest day of the year, you would need 160Wh / 3h or a 53 watt system.
Since PV panels seem to be rated at peak output, I'd suggest something more like 75 watts. So figure about $500 for the PV system and maybe another $100-200 for the battery. The battery should last 3-5 years, maybe even 8 or more for the larger sizes, in this service.
Solar Gary is MUCH more experienced than I am at this though, so if he has different advice listen to his.
Here is a link that might be useful: Small pole-mount PV systems
Does the pic linked below show what you have in mind ? I suppose you could then hang it on the garage with some sort of bracket. I would not count on it giving off much light hanging on a building, since it wouldn't be in full sun, as opposed to it hanging in an open sunny area.
Here is a link that might be useful: MALIBU SOLAR HANGING CARRIAGE LIGHT
Another approach would require a little electrical expertise, but would be much cheaper. Whether it's useful to you depends on what your goals are.
Buy a couple of coach lights you like, and a pair of solar lights that have what you consider adequate performance. Gut the solar lights and transfer the components to the coach lights. If necessary, enclose the electronics and batteries in a separate small plastic or metal box. Locate the PV panels in an area that gets full sun, using as much additional wire to extend them as necessary.
The downside here is that the usual inexpensive solar light is pretty feeble when it comes to light output. The ones I've used produce just a faint glow - great path markers, but not useful for actually seeing anything. It'd be enough to show you where the garage is, but not really enough to see to unlock it at 1am.
Hope this helps.


text: Mash, rice, strain and puree. This fabulous food mill separates the puree from the peel, seeds and core and allows you to control the smoothness. Price: Price pending It is ideal for cooked vegetables, fruits, soups, and great for all those people who prefer to make fresh baby food for their little ones. Included with this food mill are three interchangeable stainless steel discs: fine, medium and coarse, allowing you to achieve different textures. Comes with instructions. A must have for any kitchen Large capacity food mill for all your needs Includes 3 discs Makes a great gift Imported More


text:
New Listing
2000 VOLKSWAGEN NEW BEETLE GLS Contact for Price
- Contact for Price
- Mileage 134,126 Miles
- Mileage 134,126 Miles
- Color Blue
- Engine 4 Cyl
- Mpg Avg: 22
- Location Salida, CO
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You can save multiply searches so it's good to give some valid names, so you can easily change filters.
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Loss of (Money) DownStatic
When the We-Love-You-Jerry proponents of the new Dallas Cowboys stadium in Arlington made their case for sales tax dollars to be used for the football monolith, the main argument was that all sorts of money would be rolling int...
Doggin' the CatsStatic
Baseball is as American as apple pie, assuming the pie is stuffed with ster-oids, amphetamines, and gold-digging groupies in addition to apples. But how American can baseball be at LaGrave Field, where the Stars and Stripes bei...
Heavy BreathingStatic
There may well have been Junes just as sizzling in Cowtown before this, but for damn sure there haven't been any years on record when the city had a red-alert ozone day this early – June 9, for you asthma sufferers ...
Lyda's StoryStatic
"At this point, she looks like she has had a stroke; her left hand is curled into a ball, she is hard and rigid like a board, is nearly totally paralyzed, has a feeding tube inserted nasally as she is no longer able to sw...
Poor Ed. It's not always been easy – or profitable – for this city's favorite billionaire to play God.
As the East Side Turns …Static
Supporters of the independent-minded Louis McBee were heartbroken when he was narrowly defeated by the establishment-backed Danny Scarth in the District 4 city council race on May 13.
Downtown Hits Pay DirtStatic
The Fort Worth establishment had its prayers answered (assuming those folks can still pray without being struck by lightning).
How Did They Die? Technically.Static
Last week's article on the never-ending medical horror stories oozing from Cars-well Federal Medical Center lacked answers to critical questions that were put to a prison spokeswoman two weeks before the story went to press.
Frog FlapStatic
The Weekly's story about wheelchair-bound student Adam Main being booted out of TCU's on-campus housing ("Handicapping Adam," April 26, 2006)drew about 80 postings (at last count) on a TCU weblog.
At Least in the Movie, the Chief Got AwayStatic
The city's dogged efforts to cram gas wells down everyone's throats reminds Static of One Flew Over the Cuckoo's Nest. The movie's sympathetic characters were the mental patients, while the villain was t...


text:
54 views
How many EV will a softbox knock down off your flash?
I was shooting on the beach into the sun and using my sb-700 on camera as fill. The camera I was using, a D3200, has a max shutter speed of 1/4000 of a second and no HSS. So, I used an ND filter — I ...


text:
The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a body sample. The invention also provides a kit usable for this purpose.
1. A method for detecting cervical carcinomas, cervical intraepithelial neoplasias, or cervical carcinomas in situ, comprising determining the overexpression of cyclin-dependent kinase inhibitor p16 in a human cervical body sample by comparing the expression level of cyclin-dependent kinase inhibitor p16 within said sample to the expression level present in a healthy human cervical body sample.
2. The method according to
3. The method according to
4. The method according to
5. The method according to
This application is a National Stage of International Application PCT/DE99/02094, filed Jul. 1, 1999; which claims the priority of DE 198 29 473.5, filed Jul. 1, 1998. The present invention relates to a method for the early diagnosis of carcinomas as well as their preliminary stages, particularly carcinomas of the upper respiratory tract or the anogenital tract.
The present invention relates to a method for the early diagnosis of carcinomas as well as their preliminary stages, particularly carcinomas of the upper respiratory tract or the anogenital tract.
Preventive programs have been offered for the most differing carcinomas since the middle of the 50ies. Regarding the cervical carcinoma they are based mainly on the morphological and cytological examination of cytosmears of the cervix uteri, what is called the Pap test, which is made on the basis of gynecological routine examinations at regular intervals in women from the 20th year on. By means of the morphology of the cells, the smears are divided into various intensity degrees of dysplastic cellular changes. According to Pap I-V, these intensity degrees are referred to as normal, mild dysplasia, fairly serious dysplasia, serious dysplasia and invasive carcinoma, respectively. If the Pap test leads to a striking result, a small biopsy will be taken and subjected to a histopathologic examination, by which the kind and intensity of the dysplasia are determined and classified as cervical intraepithelial neoplasia (CINI-III).
In spite of all preventive programs, the cervical carcinoma which leads to 400,000 new cases per year is the: most frequent carcinoma in women. This is inter alia due to the fact that up to 30% of the Pap test results are false-negative.
Therefore, it is the object of the present invention to provide a method by which cervical carcinomas can be diagnosed early and reliably. In addition, a differentiation should be possible by this method with respect to benign inflammatory or metaplastic changes of dysplastic preneoplasias.
According to the invention, this is achieved by the subject matters defined in the claims.
The present invention is based on the applicant's insights that cell cycle regulatory proteins are overexpressed in many carcinomas, e.g., carcinomas of the upper respiratory tract or anogenital carcinomas, particularly cervical carcinoma, and preliminary stages of these carcinomas. Examples of the cell cycle regulatory proteins are cyclins. Cyclin-dependent kinases which regulate the cyclins are to be mentioned particularly. Cyclin-dependent kinase inhibitors which, in turn, regulate the cyclin-dependent kinases, are to be mentioned even more particularly. Examples of the cyclin-dependent kinase inhibitors are the proteins p14, p15, p16, p19, p21 and p27. The applicant has found that the intensity of cell cycle regulatory protein overexpression correlates with the degree of cell dysplasia.
FIG. 1 shows the detection of the cdk4 overexpression in HPV16-transformed cervical carcinoma cells CaSki. The indications 4 h, 8 h, 12 h, 24 h refer to the times of cell extract removal. The indication co stands for control while arr indicates the addition of the serum.
FIG. 2 shows the detection of the overexpression of cdk6 and p19 in HPV16-transformed NIH3T3 cells. The indication co stands for control.
The present invention provides a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of cell cycle proteins in a body sample.
The expression "carcinomas and their preliminary stages" comprises carcinomas of any kind and origin and preliminary stages thereof. For example, they may be carcinomas of the upper respiratory tract or anogenital carcinomas, particularly the cervical carcinoma. In connection with the latter, its preliminary stages, e.g., cervical intraepithelial neoplasias (CINI-III), carcinomas in situ (CIS), etc., have to be mentioned particularly.
The expression "cell cycle regulatory proteins" comprises cell cycle regulatory proteins of any kind and origin. For example, the proteins may be cyclins. In particular, they may be cyclin-dependent kinases which regulate the cyclins. Examples of the cyclin-dependent kinases are the proteins cdk4 and cdk6. More particularly, they may be cyclin-dependent kinase inhibitors which, in turn, regulate the cyclin-dependent kinases. Examples of cyclin-dependent kinase inhibitors are the proteins p14, p15, p16, p18, p19, p21 and p27, with p16 being preferred.
The expression "body sample" comprises any body samples in which cell cycle regulatory proteins can be detected. Examples of such body samples are blood, smears, sputum, urine, stool, liquor, bile, gastrointestinal secretions, lymph, bone marrow, organ punctates or aspirates and biopsies. In particular, smears and biopsies are indicated when the detection of anogenital carcinomas, e.g., cervical carcinomas, is concerned.
The expression "determining the overexpression of cell cycle regulatory proteins" comprises any methods which are suited for detecting the expression of cell cycle regulatory proteins or their encoding mRNAs and an amplification of the corresponding genes, respectively. In order to determine an overexpression, it is an obvious thing to compare the body sample to be examined with a corresponding body sample which originates from a healthy person. Such a sample can be present in standardized form. The (over)expression of cell cycle regulatory proteins can be detected on a nucleic acid level or protein level. Regarding the detection on a protein level, it is possible to use, e.g., antibodies which are directed against cell cycle regulatory proteins. These antibodies can be used in various methods such as Western blot, ELISA or immunoprecipitation. It may be favorable for the antibodies to be fixed on solid carriers such as test strips or latex particles.
By means of the present invention, it is possible to diagnose carcinomas early, i.e., in their preliminary stages.
A further subject matter of the present invention relates to a kit for carrying out a method according to the invention. Such a kit comprises:
(a) a reagent for detecting the expression of a cell cycle regulatory protein, e.g., an antibody directed against
(b) conventional auxiliary agents, such as buffers, carriers, markers, etc., and optionally
(c) an agent for control reactions, e.g., a cell cycle regulatory protein, a nucleic acid coding for such a protein and parts thereof, or a preparation of cells, e.g., a tissue section or cells fixed on a slide.
The above statements apply correspondingly to the individual components of the kit. Furthermore, one or several representatives of the individual components may be present.
By means of the present invention, it is possible to diagnose carcinomas early. In particular, preliminary stages of carcinomas can be detected early. It must also be emphasized that it is possible to make a differentiation with respect to benign inflammatory or metaplastic changes of dysplastic preneoplasias. Another characteristic is that the results obtained by a method according to the invention are not subject to a subjective evaluation, therefore, the false-negative results and false-positive results, of a Pap test or of histological preparations can be avoided. In addition, the present invention distinguishes itself by a rapid and simple handling, therefore, it can be used for extensive screening measures, particularly in third-world countries. Thus, the present invention represents an important contribution to today's diagnostics of cancerous diseases.
The invention is explained by the following examples.
(A) Paraffin sections having a thickness of 3 to 5 μm were produced from 20 biopsies of the cervix uteri, which comprised all degrees of the dysplastic progression from normal tissue (n=2) via CIN I (n=4), II (n=4), III (n=5) lesions to the invasive carcinoma (n=5). They were deparaffinized in xylene for 2×10 min. and rehydrogenated using ethanol. The antigens were demasked in 10 mM citrate buffer (pH 6.0) in an autoclave at 110° C. for 10 min. Thereafter, the endogenous peroxidases were inactivated using 0.25% H2O2 in PBS. Following the blocking of unspecific binding sites with horse serum (Vectastain ABC detection kit, Vector Laboratories, Burlingame, Calif., U.S.A.) at room temperature for 20 minutes, the sections were incubated with a p16-specific monoclonal antibody (Neomarkers, Fremont, Calif., U.S.A.) in the presence of 3% fetal calf serum at room temperature for 45 min. For the detection of the p16-antibody binding, a biotinylated secondary antibody (horse anti-mouse IgG, Vectastain kit, see above) was then added for 30 minutes. Thereafter, the bound secondary antibody was detected by means of the reagents and in accordance with the Vectastain kit instructions and a core counterstain was carried out using Mayer's hemalum solution.
It shows that an overexpression of p16 exists in dysplasia cells. It also shows that the intensity of p16 overexpression correlates with the degree of cell dysplasia.
(B) In addition, paraffin sections were prepared from 78 biopsies of the cervix uteri. The biopsies related to normal tissue (n=12), dysplastic lesions of stages CIN I (n=15), II (n=14) and III (n=18) as well as invasive carcinomas (n=19). The paraffin sections were treated as described in (A). The data indicated in Table 1 were obtained.
The data of Table 1 show that p16 is overexpressed in cells of dysplasias and invasive carcinomas; the overexpression increases with the degree of dysplasia towards the invasive carcinoma.
(C) Moreover, paraffin sections from 180 biopsies of the cervix uteri were treated as described in (A). In addition, the percentage cell number which reacts with the above-mentioned p16-specific monoclonal antibody was determined. A distinction was also made between HPV-positive and HPV-negative dysplasias and invasive carcinomas, respectively. The data indicated in Table 2 were obtained.
The data of Table 2 disclose that p16 is overexpressed in both HPV-positive cells and HPV-negative cells of dysplasias and invasive carcinomas. This result is confirmed by controls with normal tissue. The data also show that the percentage of cells reacting with p16 increases with the degree of dysplasia towards the invasive carcinoma.
(A) Cervical carcinoma cells CaSki which were transformed with HPV16 were cultured in the absence of serum for 72 h. Following the addition of serum, cell extracts were collected at various times, subjected to SDS-PAGE and transferred to PVDF membranes (Du Pont). The expression of cdk4 was determined using polyclonal antiserum (1:1000) from Santa Cruz. Furthermore, the expression of HPV16-E7 protein was determined with a monoclonal antibody against HPV16-E7 (1:50) from Triton. The individual immune responses were detected via peroxidase-linked second antibodies and a chemiluminescence detection system (NEN, Du Pont).
The results show that cdk4 is overexpressed (cf. FIG. 1).
(B) NIH3T3 cells were transformed with HPV16 so as to obtain an expression of HPV16-E7 protein. Cell extracts of the transformed cells were obtained and treated as described in (A). For detecting the expression of cdk6 and p19, respectively, polyclonal antisera (1:1000) from Santa Cruz were used. As far as the detection of the expression of HPV16-E7 protein and the detection of the individual immune responses were concerned, reference was made to the above statements under item (A).
The results show that cdk6 and p19 are overexpressed (cf. FIG. 2).
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Redwood Chapel Community Church is alive, renewed and vibrant today due first and foremost to the grace and mercy of God. Yet humanly sp...
The Goehner Group assists ministry organizations in achieving their mission, vision and goals through stewardship, marketing, and leadership consultation. This is accomplished through research, coaching, training and mentoring services.
We demonstrate a service attitude:
We have a long-term commitment to our Clients:
We speak truth in all of our reporting:
We are Kingdom minded:
We provide "value added" components to every project: