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UNIVERSITY OF MICHIGAN ANNUAL REPORT YEAR ENDING JUNE 30, 2002 CONTENTS About Tech Transfer . . . . . . . . . . . . . .2 Fiscal Year 2002 Results . . . . . . . . . . .4 2002 Invention Disclosures . . . . . . . . .6 Connections to the Market . . . . . . . . .8 Community Partnerships . . . . . . . . . .16 Future Directions . . . . . . . . . . . . . . .18 From the Executive Director I 'm pleased to provide you with this update on our progress in technology transfer at the University of Michigan. We are pleased with our results in commercializing university discoveries for the public good. We attribute this success to excellent technology, the wealth of talent within the University research community, and the diligence and dedication of our staff members and industry partners. Efforts to encourage wider faculty participation in tech transfer yielded significant results. With leadership from our Medical School and College of Engineering satellite offices, we achieved a 30 percent increase in invention disclosures from faculty over last year. Our revenues, which did not include any equity sales from our portfolio, totaled $5.7 million, a 46 percent increase over the previous year's royalties. Most importantly, we significantly improved our services to researchers and business partners: initiating new protocols for early assessment of technology opportunities, guiding researchers in their choice of commercialization options, and connecting with outside resources to accelerate business start-ups and licensing technology. But this is only part of the story. During the past year, we also focused on ways to strengthen our capabilities in technology transfer. In FY02 we completed our Tech Transfer Strategic Plan, developed in conjunction with University lead- ership. This process produced a consensus on our core mission, objectives and success metrics, along with a focused plan to accelerate our progress. We also worked hard to expand our business networks by cultivating deeper and broader relation- ships with outside partners, including venture capital firms, entrepreneurs, consultants, and leading corporations. We continued to enhance our New Business Development team, which provides assistance to start-up companies that license UM technology. And for the third year, our TechStart intern program connected talented graduate students to our technology projects, yielding valuable expertise for us and a rewarding educational experience for the students. All of us who make up the Tech Transfer team are proud and some- what in awe of the scope and quality of research underway at this remarkable institution. We are grateful to have a role in furthering the mission of the University by helping to transform academic innovation and discovery into products, services and enterprises that benefit society. We look forward to the year ahead with optimism and a renewed commitment to those we serve. Kenneth Nisbet Executive Director, UM Tech Transfer University of Michigan Executive Director Ken Nisbet, with Directors Elaine Brock, Robin Rasor, and Tim Faley 1 About TechTransfer The University of Michigan's continued pursuit of excellence in research inevitably leads to discoveries of great value to society — discoveries that address a broad range of problems and needs. Since 1983, when our first technology transfer office was established, hundreds of inventions and research findings have made their way to waiting and eager markets in the form of new products, services and business ventures. In the last five years, the University of Michigan completed 267 license and option agreements and launched 34 start-up companies. FULL-SPECTRUM SUPPORT Our goal is to provide faculty researchers with expertise and guidance throughout the entire technology transfer process—from initial consulta- tions, assessments and disclosures to full-blown commercialization plans, patent protection, development of prototypes and, when needed, additional funding. Through our TechStart student intern program, we provide access to graduate-student consultants in business, engineering, law, medicine, and education. And to facilitate start-ups, our New Business Development team works actively to build relationships with investors and other commercial partners. "The University of Michigan continues to work diligently to be among the top institutions in the country relative to technology transfer. This year, the State of Michigan and Governor Engler honored UM's outstanding work by awarding its Office of Technology Transfer an award for Exemplary Success in Commercializing Technology and Promoting Entrepreneurship. This prestigious award recognizes the contributions that the University of Michigan has made to the economic vitality of the entire state." — Doug Rothwell, President and CEO, Michigan Economic Development Corporation FAR-REACHING IMPACT UM Tech Transfer supports and furthers the University's mission by: ◗ Increasing the likelihood that new discoveries and innovations will lead to useful products, processes and services that benefit society. "Our goal is to be among the ◗ Facilitating new research collaborations and resource exchanges with industry, thereby nation's top five universities in providing unique opportunities for faculty and students. the realm of technology transfer. This objective, which is well ◗ Increasing the flow of research dollars and resources to the academic community. within our grasp, reflects ◗ Providing incentives for faculty to deepen and broaden the scope of their research. the powerful creativity and high prestige of the ◗ Helping to attract and retain highly qualified faculty and graduate students. University of Michigan research community and the ◗ Enriching the educational experience through student internships and work-study dedication and talent of our opportunities. tech transfer team." —Fawwaz T. Ulaby ◗ Leveraging business partnerships to stimulate local and regional economic development. Vice President for Research ◗ Enhancing the reputation and stature of the University. University of Michigan Components of the THE MISSION of UM Tech Transfer is to effectively transfer University Technology Transfer technologies to the market so as to generate benefits for the University, the Process ➥ ➥ ➥ ➥➥ ➥➥ ➥➥➥ community, and the general public. Research Invention Pre-Disclosure Disclosure Evaluation Patent/Copyright Protection Marketing Business Development Licensing Commercialization ➥ Revenue 3 A motivated and highly responsive team, well-organized satellite offices, and a firm strategic focus, all helped produce a year of solid results despite nationwide economic difficulties. In fiscal year 2002, disclosures were up significantly, indicating more interest and awareness on the part of UM faculty. In addition, concerted efforts at relationship-building with entrepreneurs, venture capitalists and other key players resulted in sixty-one license agreements and five new start-up companies. These outcomes demonstrate the University's increasing effectiveness at moving new technology into the mainstream. 2002 FISCAL YEAR RESULTS OTHER Dentistry Lit/Sci/Arts 7 17 15% 37% 2002 INVENTION Pharmacy Public Health 6 6 13% 13% DISCLOSURES Miscellaneous 10 22% MEDICAL Total 46 100% Anesthesiology 3 2% Biological Chemistry 7 5% Human Genetics 4 3% Internal Medicine 30 22% Mental Health 6 4% ENGINEERING Microbiology 3 2% Biomedical Engineering 10 9% Opthalmology 4 3% Chemical Engineering 6 5% Otolaryngology 7 5% Elec. Engin. & Comp. Sci. 58 50% Pathology 16 12% Indust. Operations Engin. 3 3% Pediatrics 7 5% Material Sciences 4 3% Pharmacology 7 5% Mechanical Engineering 21 18% Psychiatry 4 3% Nuclear Engineering 5 4% Radiation Oncology 4 3% Miscellaneous 10 9% Radiology 5 4% Total 117 100% Surgery 10 7% Miscellaneous 18 13% Total 135 100% Disclosures with inventors from multiple colleges are credited to each college. 1997 174 1998 169 INVENTION 1999 158 DISCLOSURES 2000 168 2001 182 2002 237 0 50 100 150 200 250 "Our efforts at encouraging faculty 1997 39 45 LICENSE participation in tech transfer were very successful in FY02, as can 1998 38 45 AGREEMENTS be seen in our record number of To Start-up disclosures. We also worked to 1999 39 41 Companies streamline our processes with To Established 2000 48 56 Companies the goal of becoming even 2001 52 64 more responsive to faculty and third parties interested in 2002 56 61 UM technology." 0 10 20 30 40 50 60 70 —Robin Rasor Director of Licensing, Office of Technology Transfer, University of Michigan 1997 1.8 LICENSE REVENUE 1998 3.5 3.3 (in millions of dollars) 1999 2.5 1 From Equity Welcome Start-up Class of 2002: 2000 3 1 From Royalties DermaCo Eprogen 2001 3.9 4.3 Velcura 2002 5.7 Thromgen 0 2 4 6 8 10 Quantum Signal Fiscal Year July '01–June '02 5 Target Energy Fabrication of Thick Silicon Dioxide Layers Field Tunable Probe for Combined Electric Loss Compensation Combined Radiation Detector for Neutron and Magnetic Field Measurements for Kinematically- Detection and Discrimination Detachable Snap Fits for Space Frame collimated Neutron Automotive Body Structures Beams Low-cost Satellite Imaging System Inductive Biomineral Scaffold for Tissue Method of Forming Nanofluidic Channels Dual-rail Static Pulse Clocked Flip-flop Regeneration Polymer Micro-ring Resonator Devices A Device for Measuring and Teaching MEMS-based Voltage Controlled Oscillator Ultra Precise Reconfigurable Inspection Fly Casting Porous Plug Electro-osmotic Pump Machine Ballast Free Ship Large Displacement Compliant Joints Palm Artifact Manager (PAM) Stiffness-compensated Temperature- Multi-lead Microconnection Combustion Systems of insensitive Mechanical Resonators Device Nanparticles Using a Multi-element Diffusion Burner Collimated Radiation Detector and Low-voltage and Low-power Array of Collimated Detectors Analog Circuits Modulation Optimized Spectrum Technology (MOST) Defeating TCP/IP Stack Fingerprinting Formulation of a Two- component Polymer for Delivery MASSIT Spike Sorter Method and Apparatus for Non-contact Measurement of Melt Flow Velocity in and Endovascular Occlusion of Purification of Water Laser Materials Processing Blood Vessels MEMS Micropump Selective Sorbents for Desulfurization Integrated Electro-thermal Probe A Wide Range Supply Independent of Liquid Fuels Reconfigurable Slot Antenna for VHF/UHF CMOS Voltage Reference Method and System for Applications Micro Gas Chromatograph Engineered Biological Low-power Flip-flop with Energy Cochlear Prosthesis Actuated Implants Recovery and Automatic Clock Gating Insertion Tool for Local and Circuit Simulator for Highly Efficient Miniaturized Slot Differential Shape Control Quantum and Resonant Antenna Tunneling Devices High Performance MEMS-based UM Ultrahigh Activity Catalysts for On-chip Clock Generation TECH Low-temperature Selected Catalytic Continuous-Wave TRANSFER Oxidation of Ammonia to Nitrogen Ultraviolet Laser Disclos Error Correction Method for the Method to Fabricate Displacement Detector Array of a Single-crystal Tubes Past Measurement Vacuum Encapsulation Furnace With Increased Energy Technique Efficiency and Reduced Pollutant Formation Microfluidic Device for Separating Transition-aware Global Motile and Non-motile Particles Symbolic Structure Representation Signaling Algorithm of Human Motion A Sensitive and Selective Peptide Active Shielding of On-chip Sequence for Arsenic (III) Ion Detection Fabrication of Out-of-plane Global Intercoreaction in Water Curved Surfaces Smart Bandage Light Directed Spatial Generation of Acids A Method to Apply Constraint-based Rapid Nano Patterning of and Bases from Precursor Molecules Heuristics in Collaborative Multiple Materials on a Substrate in Solution Design A Reconfigurable Multispindle Head High Performance Nonplanar Inductors Integrated Printed Circuit Board Flow Channel Field-assisted Bonding of Insulator Reversal Imprint Technique to Eutectic Solder Integrated Surface and Depth High Speed Drilling Machine Acoustic Tweezers Measuring Methods On-wafer Packaging for RF MEMS Bent-beam Actuated Steerable Strain-hardening Cementitious Microplatform Composites Method for Statistical Reconstruction of X-ray Computed Tomography Images In-process Sensing and Quality Control Radiation-hard Temperature-resistant of Zinc-coated Steel Welds Neutron Detector Region Prefetching Engine Single Phase Resonant Clock Generator A Three Dimensional Mammalian Fibroid Photo-generated Reagents and Their Construct for Clinical Screening and for Energy Recovering Systems Reactions Research Low-power SRAM with Energy Recovery The Store-load Address Table and Its Porous Materials with High Surface Area Application to Compiler Optimization Technique for Reduced-tag Dynamic Scheduling Moisture Indicator for Restorative Dentistry Self-feeding Breadcrumb Trail for Dead-reckoning on Rugged Terrain Resonant-cavity Magnetic Field Controls of Mechanical Properties Probe for Millimeter Wave and Degradation Behavior of Laser-driven Radioactive Flechettes Alginate Hydrogels Frequency Domain Spatial Field Enhanced Isotope Enrichment Mapping A Method for the Production of A Method for Extending the Antagonist of Bcl-2 and Related Proteins Orthorhombic Acetaminophen Dynamic Range of Flat Panel and Therapeutic Methods Based Thereon Pulsed Carrier Gas Flow Detectors Ablation Catheter for Treatment of Atrial Modulation for Selectivity Instrumentation for Detection Fibrillation Enhancements with Gas and Imaging of Fluorescence Prevention of Acute Graft Versus Host Chromatography Resonance Energy Transfer Disease High Capacity Methane Sorbents Prevention of Noise-induced Bronchial Blockers Nitric Oxide Releasing Acrylic Polymers Hearing Loss 3D Protein Separation Stretch Pivot Coordinates for Prevention of Cisplatin-induced Deafness A Human Promoter that Directs Podocyte Representing Human Posture Specific Transgene Expression Molecular Targets for Chemotherapy Interventions to Protect and Regrow the Auditory Nerve Detection of Quanylyl and Adenylyl Cyclase High Temperature Chemical Crosslinkers Activity A Microcarrier System for Production Noninvasive Nonlinear Method for of Recombinant Proteins Diagnostic Biomarker in Lung Seizure Prediction Adenocarcinoma A New Polyclonal-based Expression Profile of Prostate Cancer (ELISA) Assay for the Dopamine Receptor Ligands and Multiorgan Gene Expression Profiles Detection of Loxoceles Therapeutic Methods Based Thereon of Systemic Inflammation/Sepsis Spider Venom Enhancing Diabetic Wound Healing Novel Methods of Diagnosis Markers for Pancreatic Peptide Analogs as Selective of Angiogenesis Cancer Diagnosis Inhibitors of Thrombin Activation Software for Kinematic Blood Hemolysis Analyzer Image Archiving System Assessment of the Shoulder Prospective Identification and Methods of Preventing Characterization of Breast Cancer and Treating Microbial Stem Cells Infections Small RNA Molecules for the Inhibition Antimicrobial of Gene Expression in Cells Nanoemulsion Microarray Analysis of Gene Expression Compositions and Methods FY02 in the Aging Human Retina Mouse Eye Gene Microarrays for Methods to Inhibit or Enhance the Binding of Viral DNA to Genomic Host DNA ures Investigating Ocular Development Surface Transfection and Expression and Disease Procedure Histidine-rich Proteins as Targets for Replication Deficient Adenovirus Vectors Antimalarial Therapy and Methods for Making and Using Them Genes Preferentially or Exclusively Packaging Technique for Microfluidic Expressed in Cerebral Cortex or Elastomer Chips Transgenic Mouse Model of Elevated Cerebellum Stabilization of Tetanus Factor IX Causing Myocardial Fibrosis Quantitative Immuno-Cyto-Chemistry Toxoid Encapsulated in Targeting and Delivery of Nucleic Acids in Tumor Tissues PLGA Microspheres to Intestinal Cells Methods for the Production of An Immunoadsorption Computer-aided Diagnosis (CAD) Genetically Modified Animals Device for the Treatment System for Detection of Lung Cancer Method to Improve Factor VIII Secretion of Immune Thrombocytopenia Purpura (ITP) Method of Treating Systemic Sabel Lymph Node Retractor Inflammatory Response Syndrome A Universal Delivery System to Achieve Agonists for Treatment and Prevention Ideal Drug Therapy Ultrasound Gating of Cardiac CT Scans of Alzheimer's Disease Polymer Compositions that Elicit a Strong Dynamic Foot Orthosis Method of Modulating and Sustained Antibody Novel Kinases: Sequence and Inflammatory Response Response Function Bimolecular Fluorescence Magnetically Modulated Device for Dentomaxillofacial X-ray Complementation Assay Chemical Sensors for Computed Tomography for the Analysis of Protein Background Rejection Interactions Mouse-model of Hereditary Spastic Inlet Adaptor for Low Flowrate Paraplegia ATLAS Method, Version of the IOM Personal Amplification Typing Inhalable Aerosol Sampler Human Gene Expression Cassettes for of L1 Active Subfamilies Effective Intracellular Delivery of Small Method of Patterning Nanoparticles Interfering RNA Mouse Model of Respiratory Distress and Pituitary Audio Distributor "Sound-Go-Round" A Noninvasive Assay for Quantitation Insufficiency of BACE Activity Inhibitors of Bcl-2 and Its A Generalized Approach to In-situ Related Proteins Formation of Metal-based Pharmaceutics 7 Connections to the Market A s a graduate student in philosophy, Susan Dorr Goold had what she calls "a deep scholarly interest" in theories of justice and the allocation of scarce resources. Medical school intensified that interest, especially as it pertained to health care for the uninsured. And so it was that in 1995, soon after joining the UM Medical Center faculty, Dr. Goold linked up with like-minded colleagues to create an exercise in deliberative democracy, "a method by which individuals could participate in health care planning and rationing decisions." The result of their efforts was Choosing Healthplans All Together™ (CHAT™), an education and research tool in the guise of a board game. Today, Dr. Goold is director of the Medical School's Bioethics Program, and CHAT has been used for policymaking and research projects from North Carolina to California. "CHAT addresses the major obstacles to individual participation in health care decisions, things like apathy, intimidation, fear, and lack of access to information," says Dr. Goold. "By simplifying the technical aspects, making the process fun and enjoyable, and structuring discussions among 'players,' the game increases awareness and stimulates grass-roots dialogue about the problem of limited resources. It makes people aware that insurance is a group product and that it's important to spread the risks and benefits." She notes that CHAT the game has broad applications for consumers, researchers, employers, insurance companies, policy- makers, medical service providers, and community- Choosing based organizations. CHAT continues to evolve. The board game has been transformed into software, and a web-based version is in the works. An inexpensive, Healthplans portable edition designed for educators (nicknamed CHAT Lite™) is being used at Loyola University and UM. All Together Dr. Goold is grateful to Tech Transfer for its assistance with licensing and agreements. "Among other things," she says, "they worked to protect the intellectual property so that, for instance, any data collected will be available to researchers." It's likely that, in the future, Tech Transfer could be involved in licensing the game to an outside vendor. High-level pharmacy coverage? Long-term care? Fertility treatments? Accupuncture? Dr. Susan Goold (pictured far left) spins the wheel in the game of CHAT where individuals design their own health care plans by choosing from multiple coverage options. Then, working with progressively larger groups, they come to agreement on a health care plan that reflects a consensus in values and priorities. 9 Handylab Getting a Sense of the Future I n a birthing suite, a woman goes into labor. The nurse on duty quickly takes a vaginal swab, places it in a syringe containing a small amount of buffer solution, and injects the liquid into a port on a small hand-held instrument. Then, by pressing a single button, she triggers a fully automated DNA analysis. In less than 30 minutes, she'll know whether or not the baby could be exposed to Grade B Streptococcus (GBS), a potentially fatal pathogen—treatable if detected early—that's carried by up to 20 percent of all new mothers. Thanks to a start-up company known as HandyLab—and the breakthrough research findings of two University of Michigan graduate students—this scenario is being repeated in pre-clinical trials at the UM Medical Center and Baylor College of Medicine in Houston. Within the next three to five years, the same on-site technology may be widely used for diagnosing a whole range of infectious and genetically-based diseases, and for detecting airborne pathogens such as anthrax and smallpox. The research that drives these remarkable nano-devices was developed over a period of seven years by chemical engineering Ph.D. students Kalyan Handique and Sundaresh Brahmasandra and their faculty advisors, Professors Dr. Mark Burns (Chemical Engineering) and Dr. David Burke (Human Genetics). In 1998, their portable acid- and protein-based analysis systems earned a place on Science Magazine's list of Top Inventions of the Year. And in June of 2000, the two former students launched HandyLab with $2.4 million in funding. In 2001, the company began seeking $3.5 million in Series B funding, and came away with $5.5 million instead. "To be oversubscribed in this economy is quite an achievement," notes HandyLab President and CEO Michael Farmer. He points out that the company is Developed by HandyLab, now receiving significant additional funding in the form a hand-held sensor is of Defense Department and NIH grants and R&D programmed to detect the presence of common contracts. Among HandyLab investors is the Wolverine viruses and bacterial Venture Fund, administered by Michigan Business infections within 30 min- School students. utes or less. Equipped "We're very pleased with the business relationship with the capabilities of a $400,000 laboratory, the we've had with the University of Michigan," Farmer says, disposable cartridge will adding that "Tech Transfer was absolutely crucial to the cost only a few dollars to start of the company. Without their contributions, manufacture and particularly in the areas of patent protection and business the reader/analyzer will be comparable in cost planning, there wouldn't be a HandyLab today." to low-end PDAs. The Arbor Sweet Networks Flow of Success S ecurity is a top concern for the operators of critical networks. Government agencies, service providers and large enterprises all face rapidly evolving threats such as denial of service (DoS) attacks, network worms and attacks on the routing infrastructure itself. According to Arbor Networks' co-founder Dr. G. Robert Malan, "Distributed threats cannot be effectively addressed with perimeter- only solutions such as firewalls and intrusion detection systems." That fact helps to account for the phenomenal success of Arbor Networks' flagship product, Peakflow™, a distributed network anomaly detection system that had its start in the UM research lab of Dr. Farnam Jahanian, professor of electrical engineering and computer science at the College of Engineering, and the thesis work of Malan, his then-gradu- ate student. Peakflow closes the gap between the detection of a threat and its resolution, protecting the availability of critical networks. In the late 1990s, Jahanian and Malan decided to create a com- mercial version of their research prototype, originally devised to protect UM's educational network from DoS attacks. With funding from Battery Ventures and Cisco Systems, they officially launched Arbor Networks in February of 2001. Today, Peakflow is being deployed by a broad range of govern- ment agencies, leading service providers and corporations. The past year was filled with milestones. Despite a generally weak economy, Arbor Networks experienced solid growth and won key customer accounts. In August, the company announced that it had raised $22 million in Series B financing from top-tier ven- ture capital firms and strategic investors. Most of the new funding is earmarked for new product development. Arbor Networks has also been recognized as one of Described by its creators as a distributed, scalable, UPSIDE Magazine's Hot 100 Private Companies in 2002, non-intrusive network availability Red Herring's Ten to Watch 2001 and Network World's Ten solution, Peakflow™ enables Start-Ups to Watch in 2001. large enterprises and providers Co-founders Jahanian and Malan are quick to acknowledge early to detect and counter network threats, including denial of ser- contributions made by the Office of Technology Transfer. "I credit vice attacks. In 2001, Arbor Tech Transfer with helping us move through the start-up process judi- Networks introduced a new ciously and getting our technology to market quickly," says Professor feature that gives Peakflow™ Jahanian. "It would have taken us an additional six months otherwise, the ability to detect worms and viruses as they and we would have missed important opportunities to raise money and propagate through large capture emerging markets." networks. 11 Taking a Sound Approach to Business Quantum Signal I n the late 1980s, signal processing specialist and UM Engineering Professor William J. Williams (above right) received an unusual request from the Office of Naval Research. Would he be willing to work with biologists at the Woods Hole Oceanographic Institute to "We're fundamentally an innovation create a system for identifying the voice patterns of individual sperm whales? Intrigued, Dr. center. Williams accepted the challenge and created a successful software program. It was some time What we later that he learned of the real application for the technology: monitoring Soviet submarines. do best is According to Williams' former student, Dr. Mitchell Rohde (above left), that story reflects develop good the core mission of Quantum Signal, a company founded by Williams and Rohde. "Our goal is technology to take technology out of the ivory tower and bring it into the mainstream," he says. "We do and license that through consulting and education as well as through the development of core tools and tech- it to nologies. The beauty of signal processing is that the systems we develop are cross-functional and organizations can be used to solve a huge array of problems." As for example, he notes that an algorithm devel- that have the oped by Quantum Signal for identifying particular words in multiple-format documents is being full-scale adapted for use in advanced security systems based on face recognition. resources to deploy those Williams and Rohde are the first to admit that, in the past, relatively few industries solutions." realized the potential of signal processing, or understood how the math-based analysis of signals and sensor data could solve their problems. But that's changing quickly. In the past —Dr. William J. three years, Quantum Signal has worked with clients in manufacturing, health care, Williams, power generation, automotive design, and national security. Currently, their superb Quantum Signal track record in face recognition, speaker verification and similar biometrics technolo- gies is generating favorable interest in industry and at the National Institute of Science and Technology (NIST), which is reviewing one of their proposals. "UM Tech Transfer has been a very good partner for us," says Williams. "They encouraged us to create a start-up company. They understand the needs of a small business. They're accommodating about technology licenses." He pauses for a second, then adds, "And they've always seemed genuinely interested in helping us succeed." A cardiac patient steps onto a treadmill. The pace and incline periodically increase until, finally, the patient is injected with a compound that traces heart blood flow. Using a technology called SPECT tomographic imaging, a com- puter then reconstructs and displays the patterns of heart blood flow and contrac- tile function on a screen. These images, along with other data generated by the same software program, will be used to assess the heart and make a diagnosis. Back in the mid 1980s, when nuclear medicine tomography was in its infancy, there was no way to quantify or display the inherently three-dimensional information. Instead, researchers were forced to work with planar, 2-D images. Nuclear cardiologist Dr. James Corbett and colleague Dr. Tracy Faber at the University of Texas Southwestern Medical Center in Dallas created the first com- mercially available computer application to generate quantitative 3-D displays of heart blood flow and function. Approximately ten years later, Corbett joined forces with UM colleague and research scientist Dr. Edward Ficaro to develop the next generation of this software program, called 4D-MSPECT. As Dr. Corbett explains, "4D-MSPECT grew out of clinical and research needs for a tool to efficiently and realistically display and quantify gated tomo- graphic studies of heart blood flow and mechanical function. In essence, we needed a technology that would give us access to the wide range of diagnostic information these studies can provide. We ultimately developed a sophisticated computer soft- ware application for cardiac nuclear medicine image display and analysis." Corbett and Ficaro have con- tinued to enhance 4D-MSPECT the software, inte- grating new func- tions such as auto- matic report generation and exten- sions to other imaging techniques Getting to such as cardiac PET imaging. Working with representatives from Tech Transfer, Drs. Corbett the Heart and Ficaro licensed 4D-MSPECT to corporate giants such as General of New Electric, Siemens and Philips. "With assistance from the University, we were able to obtain Imaging FDA approval. We are now better able to adapt, develop and extend new technologies within a Technology constantly changing, increasingly competitive environment." 13 Fueling Tech Transfer with TechStart Business Expertise T he sign on the glass door reads "LaunchPad." Step inside and you'll find a large, light-filled room where young business consultants are hard at work—coaxing information from computer screens, preparing reports, analyzing data, generating presenta- tions, negotiating with vendors, scheduling meetings. What makes this scene unusual is that these particular consultants are actually University of Michigan graduate students from the schools of business adminis- tration, law, engineering, information, and education. They're part of TechStart, a summer internship program sponsored by UM Tech Transfer. And their clients are faculty entrepreneurs and local start-up firms. Now in its third year of operation, TechStart is funded in part by UM's Zell-Lurie Institute for Entrepreneurial Studies and the Michigan Economic Development Corporation (MEDC). The program continues to win accolades from both clients—who benefit from the students' wide-ranging, latest-theory expertise—and the interns themselves, who have a rare opportunity to apply their knowledge, hone their consulting skills, and get a firsthand, up-close look at the world of high-tech entrepreneurship. According to Mark Maynard, who manages TechStart, "The program is special because we recruit from across the UM campus and look to build the most diverse group possible. In doing this, we create cross-functional, multi- disciplinary teams that can understand both the cutting-edge science and the business climate for that technology. It's a powerful combination." VELCURA THERAPEUTICS: GROWING BONE BECOMES A GROWING BUSINESS This past year, 10 student consultants—selected from an applicant pool of more than 100—worked on a wide range of projects. One of the three-person teams was assigned to Velcura Therapeutics, a year-old start- up company that won the 2001 Great Lakes Venture Quest Award and generated $3.3 million in first-round funding from the state of Michigan. Located in Ann Arbor, the enterprise was spun out of groundbreaking biotechnology—devised by Medical School faculty member Dr. Michael W. Long—for growing human bone outside the body (ex vivo). Unlike other osteoporosis thera- pies now on the market that inhibit further bone loss, Long's discovery will lead to therapies that actually stimulate bone growth. According to MBA student and TechStart consultant Andrew Corr, Velcura relied on the student team "to move the company from a virtual to a physical operation." That included everything from locating and equipping an office to creating a business plan and venture capital proposals. TechStart consultants also devoted considerable time to various kinds of research: providing a detailed analysis of the osteoporosis market, evaluating vendors, and searching out prospective investors. They also assisted with patents and disclosure agreements. Michael Krol, a UM law student with a Ph.D. in molecular and cellular biology, even helped design and plan a bio-informatics structure for what will one day be Velcura's large-scale commercial labs. MBA student Jenny Kempenich researched potential strategic partnerships in Japan (where Velcura is currently negotiating an agreement), and Pacific Rim countries, and provided advice on Japanese business protocol. "These are absolutely top-notch people," said Long. "Their work was an important component in launching the company this summer. We would have been hard-pressed to do it without them, and the quality of their efforts was excellent." THE PLAY PROJECT: KEY RESOURCES FOR A SERIOUS ENTERPRISE Another group of TechStart consultants worked with Dr. Richard Soloman, asso- ciate professor of Pediatrics. Soloman is the creator of an innovative and effective therapy for autistic children known as The PLAY Project™. For the past several years, he and his team have been teaching parents throughout Michigan how to use the intensive play therapy at home. Tech Transfer is assisting with legal and potential licensing issues. Currently, the goal is to establish PLAY Project therapy training centers throughout the region. As a first step, the graduate student consultants met with their "client," Dr. Solomon, to evaluate needs and create a work plan. "Our initial challenge," says MBA student Jenny Kempenich, "was to help determine their objectives and find ways to align our services with their changing needs." "Doing our job well means After conducting extensive research on autism, the consult- really understanding the ing team developed alternative cost/revenue models, devised a potential of our technologies quality control strategy, and drafted terms and conditions for and fitting those to the needs PLAY Project therapy centers. According to TechStart consultant Ali Schriberg, of our business partners" who will graduate next year with one of UM's first joint degrees in business and —Tim Faley education, "One of our most important contributions was coming up with a Director, quality control strategy that included annual inspections, parent surveys and Technology Transfer and other metrics for gauging quality and performance. As a next step, we'll try to Commercialization–Engineering, replicate these same protocols for Michigan public school systems." A therapy University of Michigan center pilot program will be in place by the end of 2003. "Smart, conscientious, persistent and professional," is how Dr. Soloman describes the TechStart team. "They discovered information on the prevalence of autism that indicated a need for our services and raised important epidemio- logic questions about the cause of the enormous increases in the state of Michigan. The team moved our project forward immeasurably. An A+ job!" 15 Community Partnerships I n 2002, UM Tech Transfer continued to play a leadership role in organizations dedicated to the strengthening of the entrepreneurial infrastructure in Ann Arbor, and within the state of Michigan. Here are a few examples of some of the programs and organizations which have benefitted from these collaborations: "UM Tech Transfer ◗ Smart Zone/Accelerator has been a wonderful This year the Ann Arbor /Ypsilanti area was designated partner for the a Smart Zone by the Michigan Economic Development community. From Corporation (MEDC). This designation provides for state early endeavors support to establish resources to accelerate technology busi- to start the ness creation within the community. UM Tech Transfer Ann Arbor IT Zone provided leadership for the planning of this proposal, and to more recent work with the Smart Zone will play a central role in fostering and receiving the bene- Business Accelerator fits of the resultant expanded entrepreneurial efforts. Proposal, they have shown the depth of ◗ MichBio their commitment." MichBio, a non-profit organization dedicated to driving —Chuck Salley, "Working with our community the growth of the life sciences industry in Michigan, has Ann Arbor IT Zone partners, we've made great played a highly visible role in improving the climate for strides in creating an established and emerging biotechnology companies. UM environment to support Tech Transfer representatives have taken leadership roles within and foster our research MichBio, participating in networking events, collaborating on and tech transfer initiatives." infrastructure development projects, and providing strategic — Elaine Brock direction from the Board of Directors. Director, Office of ◗ Ann Arbor IT Zone Technology Transfer and Now nearly three years old, the Ann Arbor IT Zone is recognized as a leading Corporate Research—Medical, provider of educational content in the areas of entrepreneurship and new busi- University of Michigan ness development. UM Tech Transfer has provided board leadership and assisted with several initiatives, including the Smart Zone program, in which the IT Zone is the lead organization. In addition, the IT Boot Camp is an innovative four-day and four-night business development program that has "kick-started" more than a dozen new business ventures with the help of UM planning, course delivery and mentoring. ◗ BioMed Expo As the founding member of this state-wide networking event, UM Tech Transfer was a driving force in this premier annual showcase of leading-edge biomedical research, education and commercialization. Now in its third year, the BioMed Expo provides face-to-face interactions for hundreds of researchers, entrepreneurs and service providers in an energy-charged setting with industry experts, service providers and established and emerging companies. ◗ Ann Arbor Area Chamber of Commerce UM Tech Transfer assists with many of the programs of the Ann Arbor Area Chamber of Commerce, including Agenda Ann Arbor, an annual conference exploring the growth and future of our community, and Leadership Ann Arbor, a year-long program introducing individuals to our town and institutions. The University is also well represented on the Chamber Board of Directors. ◗ Michigan Universities Commercialization Initiative UM Tech Transfer plays a leadership position in a collaboration with Michigan State University, Wayne State University and the VanAndel Research Institute in Grand Rapids. The Michigan Universities Commercialization Initiative (MUCI), sponsored by the State of Michigan, is aimed at enriching and complementing the resources and expertise of our collective technology transfer programs, and improving the deployment of technology from Michigan institutions into our communities. ◗ Great Lakes Entrepreneur's Quest (GLEQ) The GLEQ (formerly Great Lakes Venture Quest) is an annual business plan competition designed to support technology entrepreneurship in Michigan. UM Tech Transfer, along with the Business School's Zell-Lurie Institute for Entrepreneurial Studies, played a leading role in founding the competition in 2000. UM fosters entrepreneurial activities from positions on the GLEQ board as well as participation in educational events, mentoring and resource assistance. ◗ UM Inventors Recognition Reception Expanding our traditional event for our UM inventors, we focused on a theme "For entrepreneurs and of "Celebrate Invention" to honor the investors, the 'Celebrate nearly 600 individuals who participated Invention' event is a in the Tech Transfer process. This tremendous opportunity reception featured kiosks showcasing to build and renew examples of university research and relationships with the entrepreneurship, a guest speaker reflect- world-changing inventors ing on the life of Thomas Edison, and at the UM. Events like this participation by over 100 community will catalyze the next new and business partners who paid tribute venture from the UM labs to the inventors and the inventive spirit into the market place." at the University of Michigan. —Kurt Riegger, Venture Partner, North Coast Technology Investors 17 Future Directions AN OPTIMISTIC OUTLOOK Thanks to an academic culture that fosters collaboration and encourages interdisciplinary alliances, the University of Michigan is unique both in the scope and quality of its research. Remarkable strength across disciplines has created an environment ripe for invention in areas such as bioengineering, life and health sciences, manufacturing, environmental science, and information technology. Looking ahead to the next year and the next decade, current research holds great promise for advances in everything from environmental remediation to public health and safety, and from heavy industry to nanomanufacturing. While it's difficult to predict where major breakthroughs may occur, we expect to see significant advances in fuel cell technology, cancer research and proteomics. FUEL CELL TECHNOLOGY Hydrogen, considered the ultimate renewable fuel, can be efficiently converted into electricity by devices called fuel cells. It is possible that hydrogen-based fuel cells, coupled with other power generation systems, could replace gasoline, natural gas and other fossil fuel engines within a generation. Because of this, University of Michigan researchers are focusing a number of research programs on hydrogen energy technologies in general, and on fuel cells in particular. Much of this work is taking place within the College of Engineering. Research activities also exist within the School of Natural Resources and Environment, the Business School and the departments of Chemistry and Physics (LS&A). Research is underway to develop more efficient catalysts and better reactor designs for hydrogen genera- tion, improved methods for storing and utilizing hydrogen, and new micro-fuel cells for portable devices. The successes to date are impressive—and the list is growing. Researchers from the College of Engineering are developing high-performance fuel processing catalysts and novel micro-reactors. And in the summer of 2002, the UM demonstrated its commitment to and leadership in hydrogen-based energy research by establishing the Center for Advanced Research at Michigan on Alternative Energies or CARMAe. CARMAe is based with- in the College of Engineering but will include personnel and projects from other UM units in its research/ education portfolio. CANCER RESEARCH The University of Michigan has established an impressive record of achievement and earned a place in the top tier of the nation's cancer research centers. Among its numerous facilities is the General Clinical Research Center, the largest and most widely utilized NIH-funded cancer facility of its kind. A core strength of the University resides in the wide-ranging opportunities for interdisciplinary collabora- tion. The interface of the Life Sciences Initiative (LSI) with the Medical Center and other units such as Biology, Chemistry and Engineering is creating a research "gestalt" that rivals any other major institution. Within this intellectually rich environment, where research projects run the gamut from nano-devices to tissue engineering and submolecular explorations, the role of Tech Transfer is to make connections between research and business, and to identify new applications for discoveries. Among its other plans for the near future, the University of Michigan recently received a $3 million grant from the Michigan Life Sciences Corridor Fund (MLSCF) for the Proteomics Alliance for Cancer project. This consortium will bring together a broad array of researchers from inside and outside the university to advance the tech- nology for comprehensively profiling human proteins for proof-of-concept experi- ments aimed at the prevention, diagnosis, and treatment of cancer. Initial research will focus on lung and breast cancer. PROTEOMICS The recently completed Human Genome Project has generated vast amounts of information about "Overall, the prospects for the fundamental structure of genes. Scientists are technology transfer at the University now confronted with the challenge of determining of Michigan have never been better. the functions of each gene. The key lies in pro- With a strong infrastructure in teomics—the ability to identify and measure all place, with a notable record of changes that occur in the proteins of a living cell achievement and a growing in response to its environment. network of industry contacts, we Today, the University of Michigan is poised are well positioned to help move to become one of the world's premier centers for leading-edge research from the proteomics research. The UM has assembled University to the marketplace." outstanding researchers in a vast array of fields— —Marvin Parnes including genomics, molecular biology, and bioinformatics. Associate Vice President for In addition, the new Life Sciences Institute will significantly Research and Executive Director increase both the volume and pace of cross-disciplinary research. of Research Administration Already, interdisciplinary teams are producing important, incremental discoveries that could have a major impact on the future of genomic and proteomic research. 19 The Regents of the University David A. Brandon, Ann Arbor; Laurence B. Deitch, Bingham Farms; Daniel D. Horning, Grand Haven; Olivia P. Maynard, Goodrich; Rebecca McGowan, Ann Arbor; Andrea Fischer Newman, Ann Arbor; S. Martin Taylor, Grosse Pointe Farms; Katherine E. White, Ann Arbor; Mary Sue Coleman, ex officio University of Michigan Nondiscrimination Policy Notice The University of Michigan, as an equal opportuni- ty/affirmative action employer, complies with all applicable federal and state laws regarding non- discrimination and affirmative action, including Title IX of the Education Amendments of 1972 and Section 504 of the Rehabilitation Act of 1973. The University of Michigan is committed to a poli- cy of non-discrimination and equal opportunity for UM Tech Transfer Staff (left) all persons regardless of race, sex, color, religion, creed, 1. Mark Maynard 14. Robin Rasor national origin or ancestry, age, marital status, sexu- al orientation, disability, or Vietnam-era veteran 2. John Cunningham 15. Karen Studer-Rabeler status in employment, educational programs and 3. Tim Faley 16. Doug Hockstad activities, and admissions. Inquiries or complaints 4. Mike Sharer 17. Sally Ingalls may be addressed to the University's Director of Affirmative Action and Title IX/Section 504 5. Mike Hallman 18. Linda Hamlin Coordinator, 4005 Wolverine Tower, Ann Arbor, 6. Dennis Linder 19. Barbara Latham Michigan 48109-1281, (734) 763-0235; TTY 7. Mitch Goodkin 20. Jill Cooke (734) 647-1388. For other University of Michigan information call: (734) 764-1817. 8. Rick Brandon 21. Julie Condit 9. Brice Nelson 22. Ruth Halsey University of Michigan Tech 10. David Ritchie 23. John Kane 11. Janet Vandagriff 24. Elaine Brock Transfer 12. Maria Sippola-Thiele 25. Sandra Moing Office of Technology Transfer 13. Ken Nisbet 26. Olga Furga University of Michigan 2071 Wolverine Tower 3003 South State Street Ann Arbor, MI 48109-1280 Phone: (734) 763-0614 2 Fax: (734) 936-1330 1 3 4 9 5 6 7 13 8 10 16 11 12 14 Satellite Offices: 19 21 15 18 20 Office of Technology Transfer and 23 22 Corporate Research—Medical 17 24 25 26 715 E. Huron Street Ann Arbor, MI 48104 Phone: (734) 763-6363 Fax: (734) 615-0076 Office of Technology Transfer and Commercialization—Engineering 143 Chrysler Center 2121 Bonisteel Boulevard Ann Arbor, MI 48109-2092 Phone: (734) 647-7080 Fax: (734) 647-7075 Website: www.techtransfer.umich.edu Editor: Linda Fitzgerald Contributing Editor: Mark Maynard Designer: Kathleen Horn, University of Michigan Marketing Communications Project Manager: Cynthia Camburn, University of Michigan Marketing Communications Photography: Philip Dattilo, Per Kjeldsen, Marcia Ledford www.techtransfer.umich.edu
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By A. R. Rahman
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Balleilakka composed by A. R. Rahman. Arranged by Ethan Sperry. For SATB choir. Global Rhythms Series. Recorded on ES.CD-10. Secular. Octavo. Published by Earthsongs (ES.S-339).
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We tapped the bronzing expert at cult self-tanning brand St. Tropez for her secrets to an even, natural-looking glow sans sun.
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text: Michael Forever Tribute Concert By Nick Cooper February 6, 2012 2:14 PM Share on Facebook Share on Twitter CARDIFF, WALES – OCTOBER 08: performs at/ attends the 'Michael Forever Tribute Concert' at Millennium Stadium on October 8, 2011 in Cardiff, Wales. (Photo by Tim Alban/Getty Images) Category: Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of Mix108 Recommended For You Around the Web


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29th November 2014
The Sun offers advice to reader who thinks he is gay after threesome 31
7:19 PM — The Sun tried to help a man after he had a threesome with his wife and a male escort.
5th June 2013
Tory MP cleared by tribunal over lesbian housekeeper threesome allegations
5:46 PM — A Conservative MP has been cleared of allegations that he invited his former housekeeper to join a threesome after an employment tribunal rejected the case.
13th May 2013
Georgia: Government minister arrested for secretly filming male journalists having a threesome 3
1:54 PM — Georgia's deputy interior minister Gela Khvedelidze has admitted posting a video online of three journalists engaging in a threesome.


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Wightgirl's Mom Answers Activity
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Hi, I have been working from my home office for the past 9 years, it's been a great write off and allows me to spend time with the ki...posted by itsmekathrine
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I can hear your distress, motherhood is a big adjustment and that's without the loss of income. The ladies below make excellent point...posted by randomgem18


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Oh The Feels
The nicest surprise ever. And probably the coolest bank in the world, of course it's in Canada.
The nicest surprise ever. And probably the coolest bank in the world, of course it's in Canada.
Watching my dog play is always good for a laugh. Unlike normal Gunner that likes to play with Kate. My dog Zeke would prefer to play by himself, he fetch occasionally. But mostly he just wants the ball & to be left alone.
It feels like I have been waiting for this movie for so long. And in reality it's only been nine months.
I'm officially, official! After six years of working with MIX 106 it has finally happened!
That's exactly what I thought about the new movie. Because we had Ninja Rap by Vanilla Ice for the old movies. And then I heard the great news!
It's about fifty percent of the women I know are overly excited for the new trailer of Fifty Shades of Grey. And now I know why!
Mix 106's Stephanie Kay was out at Gordmans giving out prizes to listeners that stopped by at their new store located right off Parkcenter and Apple Street right next to Albertsons. Their always low prices of 60% off department stores and outstanding home decor section is something you can't live without! So come check it out!
I just had this realization that my cat is more like a roommate than a pet. I know that may seem odd, but I'm serious!
I was driving to work yesterday & all five lanes of traffic are stopped. No one's honking nothing & we were just sitting there.


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($90) Saturated ruby. Broad, highly aromatic bouquet of blackberry, blueberry, cherry-vanilla and fresh flowers. Spicy red and dark berry liqueur flavors coat the palate, with silky tannins providing firmness. This juicy, suave, very fresh wine finishes with vibrant fruit and excellent length. Delivers serious flavor impact with no excess weight or ripeness. Bet on this rewarding at least a decade of aging.Author: Josh Raynolds
Professional content appears courtesy of Vinfolio
RWT (= Red Wine Trial) is a trial that is rather long in the tooth now. It started in 1997 in response to the Baross's growing réclame, and that réclame was celebrated with French rather than American oak. To be honest I'd forgotten this when I first tasted it but the extra focus and tightness on the nose compared with the other reds here is evident from first sniff. Dark crimson, meaty nose without any excessive alcohol obvious on the nose – dryer and tighter somehow. But on the palate the fruit (presumably some old vine stuff) is very rich and round and even slightly salty – some syrup and ground-up tar and gravel is what I got on the palate but I've now read what winemaker Peter Gago gets on this: "fresh blueberry (pie) and blood plum. A barrel-fermented vapour net entraps scents of cinnamon and nutmeg, violet and bergamot. Flirting strawberry yogurt (creamy) and freshly cut rhubarb aromatics unwittingly entice". Crikey. I found it not at all sweet – drier than most of these wines - but certainly strong flavours that reminded me rather of gravel essence. Acidity marked but not jagged. £45Drink Dates: 2015-2025
Professional content appears courtesy of Vinfolio
Since its founding in 2003, Vinfolio has brought the rarest and highest-quality wines to the the collector market. Located in San Francisco and Napa, we are a company of wine experts who understand and value the importance of wine provenance. Our premium supplier relationships and first-in-class technology help us protect your wine from sourcing through shipping with extraordinary care that only we can provide. Don't trust your fine wine with anything less!Learn More


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Take a look at this ABSOLUTELY DROP DEAD GORGEOUS - SURVIVOR - APPROX. 55K ACTUAL - ORIGINAL MILEAGE - 1947 Plymouth Super Deluxe Business... More
1949 Plymouth Special Deluxe, Great car for driving every weekend. Got few years back, repaint it and new wheels. new breakline. Engine is original.... More
The early post-war Mopars are unquestionably some of the best-driving cars of the era. Forget their low sticker prices, what you got for your... More
THIS IS A REALLY NICE AND WELL CARED FOR 1949 PLYMOUTH P18 WOODY STATION WAGON. WE BELIEVE THIS CAR HAS BEEN IN NORTHERN CALIFORNIA... More
1947 Plymouth Special Deluxe Station Wagon In 1947, the only woody wagon produced by Chrysler Corporation was the Plymouth. But even producing that one required... More
Special Deluxe Convertible, Original 6 cyl Eng Std Trans etc... 5 year old Paint in excellent condition Drive or Show... More
maroon metal exterior, multiple type and color exterior and interior wood body with tongue and groove interior headliner, floor and cargo area, brown leatherette... More


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Rayman 3D
Terrible port. The framerate is just awful.
Even the n64 version performed better than this. This game has both low unstable framerate and lots of stuttering. Let's not mention the excessive ghosting effect with the 3D turned on. UbiTrash really couldn't care less. Anyone who played the psx version recall if it performed better than this terrible port or not?
You are right, frame rate is unacceptable, especially since the n64 version performed better. Still better than ps1 though. Looks better than ps1 as well. The issue here is that the 3ds is very powerful, more than even dreamcast or ps2. So there's no excuse for the clear lack of effort in this port. In addition to the unstable frame rate, they also removed the dynamic lighting from the dreamcast and even n64 versions.
However, the game is still playable and far better than the ds port.
NEVER judge a game you have not played.
Yeah, I'm disappointed that the game doesn't run in 60fps like the Dreamcast version, but at least it's better than the DS version.
Xbox Live Gamertag: DJ Nario


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Dr. Surinder S. Dang, MD
Cardiovascular Disease
- 17150 Euclid St Ste 200
Fountain Valley, CA 92708
- 2 Locations
- (714) 751-0995
Dr. Surinder S. Dang graduated from the Gov't Med Coll, Baba Farid Univ Hlth Sci, Patiala, Punjab, India in 1968. He works in Fountain Valley, CA and 1 other location and specializes in Cardiovascular Disease and Internal Medicine. Dr. Dang is affiliated with Chapman Medical Center, Fountain Valley Regional Hospital & Medical Center and Huntington Memorial Hospital. He speaks English, Korean, Spanish and Vietnamese.View More
Gender: Male
Languages Spoken: English, Korean, Spanish, Vietnamese
Cardiovascular Disease, Internal Medicine
Medical School: Gov't Med Coll, Baba Farid Univ Hlth Sci, Patiala, Punjab, India; Graduated 1968
*This physician has multiple office locations. See Office Information for details.


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Any Information?
Has anyone heard if September 20th sailing on the Zenith is cruising to Bermuda? Any information would be appreciated.
Thank you.
Re: Any Information?
Not yet..I am on that sailing too. If you go to the Celebrity site at the bottom click on about us..Then press room..If there is a change it will be under Fabian..Lets hope we get there..I ahve waited so long for this trip and I am from the NE..
Re: Any Information?
Thank you Janz.......I will check out that site.....i hope we go to bermuda too....I love it there............
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- Our little one is in Great Ormond Street hospital this is giving her fun whilst so very poorly.
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Published on: 24 February 2015
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product code: 139109
see more in this range by ELC
Enjoy fun sounds and washing accessories for realistic pretend play. Let's pretend to wash out fabrics- now we can peg them up on the airer to dry, just like the real thing. Now we can switch on the iron, pretend to fill it with water from the bottle and press a button to hear the steam whoosh! Let's place out fabrics on the ironing board and get them nice and smooth.
Not suitable for children under 36 months due to small parts. Requires 2 x AA batteries.
Quick facts:
-Ironing set and washing accessories
-Press button on iron for sounds
-Great for imaginative play
1 x table top ironing board
1 x plastic iron with sound
2 x hangers with pegs
1 x airer
2 x pieces of cloth
1 x water jug
This toy encourages your child to enjoy using their imagination.
This toy inspires your child to explore and enjoy the world around them.
|Fun Factor
|Value for money
|Overall rating
|Scores 9.0 out of 10 based on 9 reviews
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Normally delivered within 5 working days (exclusions apply including postcode restrictions and extended timescales). Exceptional delivery circumstances beyond our control such as bad weather or courier delays may cause your order to take longer to deliver.
Delivery within 2 working days to UK mainland addresses. Regrettably this service is unavailable for deliveries to Northern Ireland.
Collect from your local store. This service is available in the UK only.Please be advised that we will hold your order for a maximum of 7 days, after which time your order will be returned to our warehouse
ELC are happy to refund or exchange any unused merchandise returned within 28 days of purchase upon production of your receipt, as long as they are returned in an unused condition and in their original packaging. Please see Terms and Conditions for details. This does not affect your rights if the product is faulty or mis-described.


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Author Biography
Jerry Kindall is the founder of Manual Labor, a technical writing and Web design firm specializing in the Macintosh. His music collection includes, at last count, over 900 CDs.
Go Back and Forth Fast in Preview
If you're reading a PDF in Apple's Preview software, and you follow a bookmark or an internal link to move around within the PDF, you can quickly return to where you were by pressing the keyboard shortcut Command-[ (that's Command-Left Bracket). Or, you can choose Go > Back.
The command works iteratively, so you can go back to just the previously viewed page or if you issue the command again, to the page before that, and so on. There's also an equivalent Go > Forward (Command-]).
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Rats in Tangerine Tree
I have roof rats eating my tangerines (on the tree) and cannot get rid of them.
Many traps (4" drain pipe in "T" shape) are scattered around the yard with poisoned grain, d-con, and small blocks of rat poison but none of those has been eaten.
Anyone think of a way to get them before they eat all the fruit?
you might check to see if you have any wires or other avenues the rats may be using to access the tree that would not require them to be on the ground where your bait is. you might also try tieing the bait blocks to the limbs of the tree where you see the most oily smudges.
I hung a wooden rat trap on the trunk of the tree last night and this morning had a rat. Used a small piece of Snickers candy bar and he went for it. No takers on the electronic trap with the same bait.
Trying for a second one this evening.
try peanut butter (or peanut but i find peanut butter more appetizing and apparently so do rats) m&ms and oversized glue traps as another alternative thats cheaper and you can nail them right to the tree or hang them using a holepunch and some twine. do it in bulk and clear em all out ASAP
I have been noticing that my parsley that was thriving on the front porch was being eaten. There is now nothing left except short stems. Then I noticed that all my succulents have been eaten in the same way. Nothing left but stems. This is not the work of snails. There are no slime tracks and the plants have been eaten by something with a big mouth. We have a lot of rats due to my bird feeders and I noticed rat(I think) droppings next to one of the succulents. I also have squirrels. Does anyone know if rats or squirrels eat plants? If so, this is a first for me. If rats eat tangerine perhaps salad is also on their menu.
Thanks for any help.
So guess the rats are what are eating my succulents. Thanks to everyone who replied. However, I was horrified to see that folks are using poison! Raptors(Hawks and owls) and other critters eat the poisoned rats and then they die. It is one of the most common causes of raptor death in the world. I am willing to sacrifice my succulents(or raise them indoors) in order to save a bird. I hope you all consider other methods and thank you for responding. I am sure that if I removed my many bird feeders, I would have less of a problem. This is what you get when you interfere with Mother Nature. I guess I was hoping for a non-lethal solution and should have made that clear.
@little ebe
Poisoning of rodent predators really depends on the chemical used. The active ingredient in the most common rodent baits used in pest control carry zero risk of secondary poisoning (the rodent metabolizes the poison prior to death, so the eagles or house cats that eat a poisoned rat don't die). I'm not perfectly sure about DCon, but in my experience rodents know to avoid DCon.
To the OP: I'd see if a local pest control company will cut you a deal on a rodent-control only program; they'll put out bait boxes and refill them regularly.


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By HarlemGal
What does The Tonic Bar located in Times Square have in common with Harlem? The Tonic Bar is owned by a couple who live in Harlem. They've been residents of Harlem since 2006. The couple behind The Tonic Bar in Times Square have now decided to invest 100 percent in where they live by launching Harlem Tavern, a neighborhood bar & grill, at 2153 Frederick Douglass Blvd. This is the space we told you about back in April how the corner gas station/auto shop was up for lease. (Oh…and a reader too had sent us an update on the recent construction happening at this corner space.)
Today, one of the owners of the upcoming Harlem Tavern spoke directly with HarlemCondoLife to tell us why they are putting their dinero dollars into where they live-particularly Frederick Douglass Blvd.
According to Sheri Wilson from SoHa 116 Restaurant Corporation and co-owner along with her husband says Harlem Tavern will be a restaurant that is representative of Harlem. "Harlem Tavern is going to be a place for everyone. Harlem is such a diverse place. We are creating Harlem Tavern to capture and accommodate that diversity," says Wilson.
Wilson says word recently got out about their exact plans cause their website was just finished and hit the internet. She said "you're the first we are speaking to."
They still have several processes to complete with NYC's Department of Buildings. However, they've built-in plenty of time to open in their business timeline, which is not soon. Wilson says they are aiming to open after the new year. "If all things go as planned, we plan to open in February 2011." She said if they make that deadline they will get heating lamps to accommodate customers and the winter weather.
In closing, Wilson explained why Frederick Douglass Blvd? "Harlem is a great place to live and Frederick Douglass Blvd is a wonderful street that holds enormous potential for growth." We could not agree more with Sheri Wilson! We have dubbed FDB as "restaurant row" and the "gold coast of Harlem." As each day passes, our predictions are becoming more and more of a reality.
A special congrats to our fellow Harlemites on their plans with Harlem Tavern! May everything fall in place and so that we have another new and interesting place to hang! Salude!
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An interesting article by Thomas L. Friedman in New York Times…Continue
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Every week since last June i had been posting a discussion inviting anyone who wants to join us.So i decided to make one discussion for all the weeks. Yes i am lazy get over it ;)To all…Continue
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Tomorrow is the day of Ashura, the tenth day of Muharram in the Islamic calendar.. Here are some funny information about that day,, Shia will beat themselves up remembering the death of Imam Hussain…Continue
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News Archive
November 27, 2006
After period of uncertainty, scholars in Boston and Havana celebrate release of their co-authored book.
November 27, 2006
An e-mail survey sent out by Brown stirs up distress among Wesleyan students who are not happy about spam.
November 27, 2006
Study on community college students' engagement suggests difficulties for the growing part-time population.
November 27, 2006
November 22, 2006
Association postpones planned meeting on college sports research, citing inadequate quality of the papers, not their critical nature.
November 22, 2006
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Anthropologists, furious that research may have inspired some Abu Ghraib tactics, vow not to assist in torture.
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Fort Bend County Libraries Reviews
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I worked at Fort Bend County LibrariesPros
Had a chance to meet some great friends.Cons
Their was no room for growth. Interviewed many times for the chance to move up with no go.
"Nice atmosphere "
- Comp & Benefits
- Work/Life Balance
- Senior Management
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I have been working at Fort Bend County Libraries full-time (more than 8 years)Pros
Family type atmosphere. Believe that family comes first. Friendly people and fun work. Nice government benefits and good insurance. Medical clinic available to employees and immediate family members.Cons
Must be a people person and enjoy dealing with the public. Pay scale not great. Administration needs to take into account the work of the "little guy".Advice to ManagementAdvice
When making changes that effect lower level or even middle tier workers, get their opinion.RecommendsPositive Outlook
"Pager at fort bend library , a place to start to carrier "
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I have been working at Fort Bend County LibrariesPros
Convenient timings, easy to start, safer place to workCons
Less growth opportunity, sometime boringAdvice to ManagementAdvice
Better if temporary personals are given opportunity to work more hours and absorbed into regular role after six months of service.


text: Movies 'Mad Max' trailer unleashes even more mayhem (and a plot) Johnny Depp injury adds to 'Pirates' delay Disney eyes live-action 'Mulan' film 'Jurassic World' TV spot: Making new dinos still a bad idea 'Home' is weekend's No. 1 movie: $54M Advertisement Top Stories 'Avengers: Age of Ultron': Mystery roles for Julie Delpy and Linda Cardellini 3 hours ago Casting Net: Anna Kendrick joins Zac Efron in 'Mike and Dave Need Wedding Dates' 5 hours ago Producer Jason Blum talks about the new Joel Edgerton-Jason Bateman thriller 'The Gift' 9 hours ago Clint Eastwood circling Richard Jewell project 11 hours ago Aaron Berg to write 'G.I. Joe 3' script 11 hours ago Latest News 'Maniac Cop' star Robert Z'Dar dies at age 64 Movies 12 hours ago 'Furious 7' diversity message; does Hollywood get it? Movies 4 hours ago Rumored 'Star Wars' spin-off star Ben Mendelsohn talks his love of the series: Exclusive Movies 15 hours ago Kevin James parodies 'Furious 7' as Paul Blart Movies 17 hours ago 'Avengers 2,' 'Ant-Man' action gets a test drive in car ad Movies 12 hours ago Killer Croc and a 'real' shift in comic-book movies Movies 5 hours ago Casting Net: Hugh Jackman in 'Apostle Paul,' Stephen Amell in 'TMNT 2' Movies 1 day ago More Headlines Latest Reviews 'Home': EW review Reviewed by Dana Rose Falcone A- 'Get Hard' review: Thug? Ugh... Reviewed by Chris Nashawaty C- 'While We're Young': EW review Reviewed by Chris Nashawaty B- 'Man From Reno': EW review Reviewed by Chris Nashawaty B 'The Salt of the Earth': EW review Reviewed by Chris Nashawaty A- More Movies Reviews Videos Advertisement Photos Jailbird watching: 13 memorable movie prisoners 13 Photos Will Ferrell's 15 greatest movie creations 15 Photos 'Batman v. Superman' character portraits: Like the looks? 5 Photos Double trouble: Movie/TV characters who fight themselves 13 Photos Fairy Godmothers: 13 who have us under their spell 13 Photos More Photos


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Bobby Benjamin to lead new restaurant Butchertown Grocery this fall
Celebrate Samoas 40th year at Girl Scouts of Kentuckiana's culinary competition, Desserts First
Make your voices heard!
It's basically the Derby of bourbon.
Inside a heated hangar at Bowman Field, beer lovers showed up to enjoy the second year of the Tailspin Ale Fest.
Louisville's best chefs sample Girl Scout Cookies to create salty hors d'oeuvres, signature drinks (spiked to caffeinated), and one-of-a-kind desserts!
This is going to be one Yankee Doodle dandy place.
A curious blend of spellbinding entertainment, fine food and drink limited to just 14 guests.
Louisville is the center of the bourbon universe.
Nine wineries are hosting free tastings of wine and chocolate pairings all weekend. Find your new favorites on a romantic outing.
Free ice cream? A way to get Louisville Cream delivered to your home? Smoked vanilla ice cream beer floats? Could this get better?
V-GRITS = Vegan Girl Raised In The South
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Latest Healthy diet Stories
As the World Health Organization's (WHO) 67th session of the World Health Assembly gets underway this week in Geneva, a UN investigator is making the case for health experts to push harder to fight the growing obesity epidemic.
Research suggests lean pork can be included in a DASH diet -- one of the best-studied eating approaches -- to help improve blood pressure DES MOINES, Iowa, April 29, 2014 /PRNewswire/ -- Adults
Pineapple Diet designed by Steve Patterson is the latest diet course for women who want to learn how to stay sexy and fit.
Almonds examined for effects on diet quality, appetite, adiposity and cardiovascular disease risk factors at Experimental Biology 2014.
People can improve their diets, according to a new study from Baylor College of Medicine, simply by enjoying white or brown rice as part of their daily routine. ARLINGTON, Va., April 9, 2014 /PRNewswire/ -- New research shows that consumers can improve their diets simply by enjoying
The 3 Week Diet system developed by Brian Flatt is a newly updated program that delivers to people simple tips to create a healthy diet plan for quick weight loss.
WASHINGTON, March 31, 2014 /PRNewswire-USNewswire/ -- In response to "Diet Drink Consumption and the Risk of Cardiovascular Events: A Report from the Women's Health Initiative," an abstract presented
Women who ate a diet high in fresh fruits and vegetables as young adults were much less likely to have plaque build-up in their arteries 20 years later compared with those who consumed lower amounts of these foods
A new study reveals that eating a Mediterranean diet is linked to a lower risk of developing diabetes, especially among those with a high risk of cardiovascular disease.
It can be difficult to know how to change a person's life around with healthy eating.
- An aromatic woolly plant (Origanum dictamnus) native to Crete, formerly believed to have magical powers.


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The Landing at Hoyt Park is closed for the season. We will reopen on May 13, 2015. Stop by and enjoy the music, the park and all that The Landing has to offer. Visit our music calendar for our complete music line-up.
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The Landing features a changing menu of local craft and imported beer.
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We are located at 1800 N Swan Blvd in Wauwatosa at the intersection of Swan Blvd and Menomonee River Pkwy.


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Meryem Saci describes her extraordinary account of how singing in a Montreal refugee court at 13 helped convince the refugee board to instantly accept her and her mother as refugees to Montreal....
PhotoVoice is an international organization and a method that uses photography as an advocacy tool to help individuals voice their personal experiences of oppression and lobby for social reform. Digital storytelling is a methodology that was developed at the University of California (Berkeley) by the Center for Digital Storytelling ). The term can also refer to more complex projects and involve hypertext fiction, animations, and any form of narrative designed to be diffused via the Internet. Mapping Memories developed weekend and longer term courses to explore these different methods of digital storytelling and you can find our more by downloading chapter 3, 4 or 5 under Book.
Center for Digital Storytelling
Young mothers with experience living on the street told their own stories through photography in "I Was Here."
Presentation: Artistic Elements in Composition


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Is it possible to have drop-down menus with multiple columns in bootstrap 2.x I know it was not in 1.x?
I think from ui perspective when you have more then 10, 20 or even 30 links in the bootstrap drop-down menu it goes down out the fold or visible area of the page, I think it would make sense being able to have multiple columns.
It would look way better to have two rows of ten or some other combination using multiple columns.


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I am trying to use the squashfs version 2.2r2 to
generate a compressed filesystem image, using the
/tmp/DIR_TO_SQUASH/* output.img -noappend -nopad -info
-le -all-root
The problem is that sometimes I see that sometimes that
there is an empty directory inode that is created:
"mksquashfs: directory inode 0x912"
Whenever this happens the filesystem image that is
created can't be read.
I was wondering if anyone else had seen this problem
and if they have, is there a workaround for it?
Phillip Lougher
Phillip Lougher
Logged In: YES
Originator: NO
This issue should not occur in Mksquashfs 2.2-r2. I have tried to reproduce this bug using Mksquashfs 2.2-r2 and I cannot get this bug to occur. This is also an old release and is not supported any more. Please retest with the latest 3.3 release and resubmit if it still occurs. Closing this bug because it has been here for a number of years, and I've never been able to reproduce the bug.


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Search the POLITICO Bookshelf
6059 Books Found in All Books
Media Control
The Spectacular Achievements of Propaganda
Price $9.95 - $14.95
Noam Chomsky's backpocket classic on wartime propaganda and opinion control begins by asserting two models of democracy—one in which the public actively participates, and one in which the public is manipulated and controlled. According to Chomsky, "propaganda is to democracy as the bludgeon is to a totalitarian state," and the mass... Read more »
A fascinating chronicle of a nation's turbulent history.Reaching back to earliest times, Martin Ewans examines the historical evolution of one of today's most dangerous breeding grounds of global terrorism. After a succession of early dynasties and the emergence of an Afghan empire during the eighteenth century, the nineteenth and early... Read more »
Last Man Standing
When Web London's FBI Hostage Negotiation Team is ambushed in a dark alley, Web is the only survivor. As the FBI investigates, suspicion surrounding Web deepens. Now, he needs help from an unlikely ally in his desperate search for the killer of his friends, and finds himself up against a force... Read more »
Whose Promised Land?
Two peoples, Jews and Palestinian Arabs, lay claim to the same piece of land. But who does it really belong to? Scripture, history, and contemporary politics add to the volatile conflict in the Middle East. Whose Promised Land?, now in a fully revised and updated fifth edition, provides an evenhanded approach... Read more »
Carnage and Culture
Landmark Battles in the Rise to Western Power
Price $13.99 - $17.00
Examining nine landmark battles from ancient to modern times--from Salamis, where outnumbered Greeks devastated the slave army of Xerxes, to Cortes's conquest of Mexico to the Tet offensive--Victor Davis Hanson explains why the armies of the West have been the most lethal and effective of any fighting forces in the world. Looking... Read more »
A Novel
Price $17.95
A sweeping novel of politics, war, philosophy, and adventure–in a restored edition, featuring never-before-published material from Gore Vidal's original manuscript–Creation offers a captivating grand tour of the ancient world. Cyrus Spitama, grandson of the prophet Zoroaster and lifelong friend of Xerxes, spent most of his life as Persian ambassador for the great... Read more »
Political Fictions
Price $11.99 - $16.00
In these coolly observant essays, Joan Didion looks at the American political process and at "that handful of insiders who invent, year in and year out, the narrative of public life." Through the deconstruction of the sound bites and photo ops of three presidential campaigns, one presidential impeachment, and an unforgettable... Read more »
Power, Politics, and Culture
Price $12.99 - $18.95
Edward Said has long been considered one of the world's most compelling public intellectuals, taking on a remarkable array of topics with his many publications. But no single book has encompassed the vast scope of his stimulating erudition quite like Power, Politics, and Culture, a collection of interviews from the last... Read more »
An Autumn of War
What America Learned from September 11 and the War on Terrorism
Price $9.99 - $13.00
On September 11, 2001, hours after the terrorist attacks on New York and Washington, the eminent military historian Victor Davis Hanson wrote an article in which he asserted that the United States, like it or not, was now at war and had the moral right to respond with force. An Autumn... Read more »
The Story of Lieutenant General Lewis B. Puller, USMC
Price $13.99 - $20.00
The Marine Corps is known for its heroes, and Lieutenant General Lewis B. Puller has long been considered the greatest of them all. His assignments and activities covered an extraordinary spectrum of warfare. Puller mastered small unit guerrilla warfare as a lieutenant in Haiti in the 1920s, and at the end... Read more »