text:
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Interleukin-1 Targeting Drugs in Familial Mediterranean
Fever: A Case Series and a Review of the Literature
Ulrich Meinzer, MD, PhD,* Pierre Quartier, MD, PhD,†
Jean-François Alexandra, MD,‡Véronique Hentgen, MD,§
Frédérique Retornaz, MD,¶and Isabelle Koné-Paut, MD, PhD*
Objectives: Familial Mediterranean fever (FMF) is an autosomal-recessive autoinflammatory dis-
order common in Mediterranean populations. FMF is associated with mutations of the MEFV
gene, which encodes pyrin. Functional studies suggest that pyrin is implicated in the maturation
and secretion of IL-1. The IL-1 receptor antagonist or anti-IL1 monoclonal antibody may there-
fore represent a new approach to treat FMF. The aim of this report was to evaluate and discuss
treatment of FMF with interleukin-1 targeting drugs.
Methods: Electronic mailing lists of French pediatric and adult rheumatologist associations were
used to call for FMF patients treated with interleukin-1 antagonists. A search for published FMF
patients treated with interleukin-1 targeting drugs was performed by screening PubMed.
Results: Here, we report 7 cases of FMF patients treated with anakinra and/or canakinumab and
discuss the clinical situations that may indicate the use of IL-1 blocking agents in FMF. The use of
drugs in FMF patients were as follows: (1) incomplete control of disease activity despite colchicine
treatment; (2) high serum amyloid A levels despite colchicine treatment; (3) impossibility to use
colchicine treatment because of severe side effects; (4) FMF in association with vasculitis.
Conclusions: Interleukin-1targetingdrugsmaybegoodcandidateswhenlookingforanalternativeor
supplementary treatment to colchicine. These observations highlight the need for controlled trials to
further evaluate the safety and efficacy of interleukin-1 antagonists in FMF patients.
© 2011 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 41:265-271
Keywords: familial Mediterranean fever, interleukin-1, anakinra, canakinumab, inflammasome
FMF is characterized by lifelong recurrent, self-limiting
attacks of fever and systemic inflammation. Serositis pre-
amilial Mediterranean fever (FMF) is an autosom-
al-recessive autoinflammatory disorder more com-
monly observed in Mediterranean populations.
senting as peritonitis is present in most patients. Other
disease presentations include pleurisies, arthritis, pericar-
ditis, skin lesions, painful scrotum swelling, and myalgia
(1,2). The attacks typically occur every few weeks to
months and last for 1 to 3 days. The most important
long-term complication is progressive systemic type AA
amyloidosis (1,2).
The Mediterranean fever gene (MEFV) located on
16p13 encodes for pyrin (3,4). The exact function of
pyrin and the pathophysiologic role of the mutations are
that the major role of pyrin is the regulation of caspase-1
activation. The inflammatory phenotypes of FMF are in-
duced by IL-1? and NF-?B, which are abnormally acti-
vated by FMF-associated mutations of pyrin (5). Conse-
quently, the blockade of either IL-1? signaling or NF-?B
activation represents possible targets for the treatment of
*Division of Paediatric Rheumatology and Division of Paediatrics, CEREMAI,
Hôpital de Bicêtre; University of Paris Sud, Le Kremlin Bicêtre Cedex, France.
†Department of Paediatrics Immunohaematology and Paediatric Rheumatology,
Hôpital Necker-Enfants Malades, Paris, France.
‡Department of Internal Medicine, Hôpital Bichat Claude-Bernard, Paris, France.
§Department of Paediatrics, CEREMAI, Hôpital A Mignot, Versailles, France.
¶Departments of Internal Medicine and Infectious Diseases, Hôpital Ambroise-Paré,
Marseille, France.
IKP received research and consulting fees for lecturing (?10,000 Euros) from
Novartis Pharma.
Address reprint requests to Ulrich Meinzer, MD, PhD, Division of Paediatric
Rheumatology and Division of Paediatrics, CEREMAI, Hôpital de Bicêtre; Univer-
sity of Paris Sud, 94275 Le Kremlin Bicêtre Cedex, France. E-mail: ulrich.
0049-0172/11/$-see front matter © 2011 Elsevier Inc. All rights reserved.
Page 2
An increasing number of interleukin-1 targeting drugs
are currently in various stages of development. Anakinra,
a recombinant, nonglycosylated homolog of the human
IL-1 receptor antagonist, competitively inhibits binding
of IL-1? and IL-1? to the IL-1 receptor. Other drugs
include longer acting molecules such as canakinumab, a
human IgG1monoclonal antibody directed against IL-
1?, and rilonacept, an IL-1 blocker that comprises the
extracellular domain of the human type 1 IL-1 receptor
coupled to a human IgG1antibody. None of them are
licensed for use in FMF patients.
Here, we present 7 FMF patients who were treated
with anakinra and/or canacinumab. Based on these cases
and those published by others, we discuss the possible
indications of interleukin-1 targeting drugs in FMF pa-
tients and review the literature.
Electronic mailing lists of French pediatric and adult
rheumatologists societies were used to call for the medical
history of FMF patients (confirmed by carriage of 2
MEFV-mutations) who had been treated with interleu-
kin-1 targeting drugs. Information about age, sex, disease
course, treatment before anti-IL-1 targeting drugs, rea-
sons for the use of anti-IL-1 targeting drugs, treatment
modalities, clinical effect, side effects, and duration of
follow-up were recorded. As the genetic analyses were
performed as routine diagnosis procedure, there was no
requirement for institutional review board approval.
They included the E148Q variant in exon 2 and exon 10
sequencing of the MEFV gene. When a single mutation
was identified in exon 2 or 10, exons 2, 3, and 5 were
also systematically sequenced as described elsewhere
(8). As both anakinra and canakinumab were given
off-label for use in FMF, patients received comprehen-
sive information and gave their consent before receiv-
ing these treatments.
To identify publications reporting FMF patients
treated with interleukin-1 targeting drugs, we searched
PubMed using the search term "FMF" alone or in com-
bination with 1 of the following terms: "anakinra,"
"interleukin-1," "canakinumab," "rilonacept."
Seven patients (4 male, 3 female) from 5 different hospi-
tals were identified. The patients' ages when starting IL-1
targeting drugs were 51, 45, 12, and 7 years (4 patients).
Disease duration before the use of interleukin-1 targeting
drugs was 3 to 6 years in children and approximately 20
years in adult patients. MEFV gene analyses showed ho-
mozygote M694V mutations in 6 patients and composite
I692de/V726A, E149Q mutations in 1 patient (case 4).
FMF manifested with fever and abdominal pain in all
patients, thoracic pain (case 1), myalgia (case 6). The
patients' clinical features are summarized in Table 1.
They were all treated with colchicine (1-2 mg/d) and
treatment was continued under interleukin-1 targeting
drugs in all patients except case 1. Six patients were
treated with anakinra and 1 patient with canakinumab.
One patient initially treated with anakinra was later
switched to canakinumab. Treatment modalities are
shown in Table 1. The reasons for using interleukin-1
targeting drugs in FMF patients were as follows: frequent
and severe FMF episodes despite colchicine treatment (2
patients); high serum amyloid A (SAA) levels despite col-
chicine treatment (2 patients); impossibility to use
colchicine treatment because of colchicine-induced toxic
neuromyositis (1 patient); FMF associated severe He-
noch-Schonlein purpura (HSP) (1 patient); and an atyp-
ical FMF episode with severe myalgia and generalized
drugs was beneficial to all patients (complete remission in
6 patients, partial remission in 1 patient). Observed ad-
verse effects were injection site reactions (3 patients) and
moderate headache (1 patient).
PubMed screen identified 8 single case reports of
FMF patients (5 adults, 3 children) treated with inter-
leukin-1 targeting drugs (9-16) (Table 2). MEFV gene
analyses were recorded in 6 patients. Five patients car-
ried homozygote M694V mutations (9,11,12,14,16)
and 1 patient carried heterozygote E148Q mutations
(10). All patients were treated with subcutaneous anak-
inra injections. In 2 patients anakinra was initially ad-
ministrated every 48 hours and later increased to daily
injections. In 1 patient who underwent hemodialysis
because of end-stage renal failure, anakinra was given 3
times weekly after hemodialysis (12). In another pa-
tient anakinra was administrated only on demand,
promptly after the onset of FMF episodes (9). The
reasons for using Anakinra were as follows: recurrent
FMF episodes with or without amyloidosis (6 patients)
(9-13,16); FMF associated with Behçet's disease (1 pa-
tient) (14); pneumonitis in a renal transplanted patient
(1 patient) (15). The response to anakinra treatment
was complete remission in 6 patients and partial remis-
sion in 2 patients (9,13). Local injection site reactions
were the only observed side effects.
Here, we report 7 FMF patients who were treated with
interleukin-1 targeting drugs. Additionally, in the litera-
ture 8 single cases have been published (9-16). Consider-
ing all published cases, the reasons for using interleukin-1
targeting drugs in FMF patients can be divided into the
following categories: (1) incomplete control of FMF dis-
ease activity despite colchicine treatment; (2) high SAA
levels and/or renal complications despite colchicine treat-
of FMF because of severe side effects; (4) FMF in associ-
ation with vasculitis.
266 Interleukin-1 targeting drugs in familial Mediterranean fever
Page 3
Table 1 Summary of Cases Reported in This Study
F, 45 yr
Reasons for the Use of IL-1
Targeting Drugs
Frequent (weekly) and severe FMF
episodes after colchicine
withdrawal because of
colchicine induced
Frequent and severe FMF episodes
despite colchicine treatment,
impairing the quality of live.
The intensity of FMF attacks
obliged him to stay at home for
?5 days/mo, negatively
impacting professional and
private live
Treatment Modalities
Anakinra s.c. daily 100
Clinical Effect
Rare moderate episodes
without fever
Anakinra s.c. daily 100
Complete remission13
Anakinra s.c. 100 mg/48 hReappearance of
Complete remissionAnakinra s.c. daily 100
Canakinumab s.c. (2 mg/
kg)/8 wk
3 F, 7 yr Frequent and severe FMF episodes
(3 to 4/mo) despite colchicine
impairing the quality of life
Severe episodes lasting for 5 days
twice a month despite
colchicine. Constantly elevated
SAA levels, even during
symptom-free intervals (200 to
834 mg/L), no signs of renal
Complete remission5
4 F, 7 yr
Anakinra s.c. at onset of
crises 1 mg/kg/d
No change2
Anakinra s.c. daily 1 mg/
Anakinra s.c. daily 1 mg/
Complete remission,
normal SAA
Complete remission,
normal SAA
5 F, 7 yrFrequent and severe FMF episodes
(3 to 4/mo) despite colchicine
with elevated SAA levels
between attacks (350 mg/L),
family history of renal
An atypical FMF episode with
severe protracted myalgia (class
III analgetics) and generalized
convulsions. No clinical effect
after colchicine dose increase to
1.5 mg/d
FMF associated to severe Henoch-
Schonlein purpura (HSP).
Continuous enteral feeding had
to be replaced by parenteral
nutrition. Treatment with
corticoids (2 mg/kg/d) and
immunglobulines (2g/kg for 2d)
did not change the severity of
HSV during 4 wk of
After 6 months without FMF- and
HSP-manifestations Anakinra
was decreased and
discontinued. Ten days after
discontinuation, HSP-symptoms
Anakinra s.c. daily 1 mg/
kg/d, during 14 d
Rapid clinical remission8
7 M, 7 yr
Anakinra s.c. daily 100
Rapid clinical remission16
Canakinumab s.c. (2 mg/
kg)/8 wk
Rapid clinical remission4
U. Meinzer et al.267
Page 4
Incomplete Control of Disease
Activity Despite Colchicine Treatment
FMF. The beneficial role of colchicine for FMF attacks is
well documented by open-labeled studies in adult and
pediatric patients as well as placebo-controlled trials in
adult patients (17). Long-term application of colchicine
leads to a complete remission in two thirds of the patients
and partial remission (defined by significant decrease of
attack frequency or remission of a single symptom) in
approximately one third of the patients with FMF (17).
However, a minority of approximately 5 to 10% of the
the latter, frequent and severe FMF attacks may severely
compromise the quality of life and increase the risk for
secondary amyloidosis. For example, insufficient disease
control with respect to severity and frequency of episodes
this report, as well as for most of the published single
cases. Anakinra for the treatment of colchicine-resistant
FMF has also been reported to be efficacious and safe in 2
adult patients with hemodialysis and/or renal transplan-
tation (12,16). This indication may represent the most
common situation for considering treatment of FMF
with anti-IL-1 targeting drugs.
Table 2 Summary of Cases Reported in the Literature
Belkhir 2007 [11]
F, 68 yr
Reasons for the Use of IL-1
Targeting Drugs
Recurrent episodes despite
colchicine, elevated SAA
levels, AA amyloidosis
Treatment Modalities
Anakinra s.c. 100
mg/48 h
Clinical Effect
Partial remission
Anakinra s.c. 100
Anakinra s.c. 100
Anakinra s.c. 1 mg/
Anakinra s.c. 1 mg/
Anakinra s.c. 100
mg/d at onset of
Anakinra s.c. 1 mg/
Complete remission5
Complete remission
Calligaris, 2008
F, 15 yrSevere episodes despite
Partial remission3
Partial remission
Mitroulis, 2008
Recurrent episodes despite
Partial remission6
Roldan, 2008
Child Recurrent episodes despite
colchicine, persisting
Recurrent episodes in a
end-stage renal failure
(AA amyloidosis) patient
recurrent episodes after
kidney transplantation
Complete remission6
Moser, 2009 [12] M, 43
Anakinra s.c. 100 mg
3?/wk after
Complete remission7
Anakinra s.c. 100
Anakinra s.c. 100
mg/48 h
Complete remission20
Alpay, 2010 [16]F, 52 yr Severe diarrhea, weight
loss, persisting
inflammation, in a renal
transplant patient
symptoms and
Anakinra s.c. 100
Anakinra s.c. 1 mg/
Bilginer, 2010
F, child Severe FMF episodes and
active Behçet's disease
despite colchicine, renal
amyloidosis, proteinuria
Complete remission
of both diseases
at 18 mo
Clinical remission,
lung opacities
Hennig, 2010
Pneumonia with opacities
in radiograph of chest
attributed to FMF in a
renal transplant patient
Anakinra s.c. 100
268Interleukin-1 targeting drugs in familial Mediterranean fever
Page 5
Impossibility to Use
Colchicine because of Adverse Effects
Treatment with colchicine is generally safe and well tol-
erated. Most adverse effects to colchicine such as diarrhea
or nausea are mild to moderate and generally respond to
dose adaptation (17). Risk factors for toxicity of colchi-
cine treatment, such as renal impairment and drug asso-
ciation (eg, cyclosporine and macrolids), have been
described (18). Recommendations for the use of colchi-
and are regularly followed in our country. However, in
some patients severe adverse effects occur despite regular
prophylactic dosage, good patient compliance, and ab-
sence of risk factors. In case 1, for example, the patient
developed colchicine-induced neuromyositis.
Other rare adverse effects of colchicine susceptible to
impose treatment discontinuation and requirement of al-
ternative therapeutic approaches include bone marrow
alterations and dermatologic reactions (17).
High Serum Amyloid A Levels and/or Renal
Complications Despite Colchicine Treatment
The most important long-term complication of FMF is
progressive systemic type AA amyloidosis (1,2). The
localization is predominantly renal leading to chronic
renal failure but amyloidosis may also occur in other
sites such as gut, heart, endocrine glands, the spleen,
and the liver. AA amyloid fibrils are processed from the
acute phase reactant SAA protein (19). The SAA pro-
duction is highly correlated to amyloid burden and
renal dysfunction (20) and may therefore be used to
evaluate the risk for systemic amyloidosis. In cases 4
and 5 the constantly high SAA levels, even during the
symptom-free periods, indicated a high risk for the
development of systemic AA amyloidosis, and case 5
had additionally a positive family history of amyloido-
sis. In both cases the treatment with anakinra normal-
ized the SAA levels. Similarly, anakinra treatment
decreased the SAA levels of an adult patient with end-
stage renal failure (12). Together these reports indicate
that anakinra may be beneficial for decreasing the risk
of systemic AA amyloidosis in FMF patients with high
FMF Complicated by
Association with Other Diseases
FMF may be associated with other diseases and some-
times it is difficult to distinguish atypical FMF symptoms
from the associated disease. Whether FMF association to
other diseases results from a common causal factor or a
common pathomechanism remains to be explored. How-
ever, the higher frequency of FMF associated MEFV
mutations in some of the associated diseases is an obser-
vation that supports this theory. Thus, it is appealing to
think that controlling FMF may also be beneficial for the
control of the associated disease and vice versa.
In case 6 the patient presented with severe, protracted
myalgia and generalized convulsions. FMF-associated
convulsions are a rare, atypical disease manifestation that
has been described previously (21). Myalgia is present in
in spontaneous myalgia, exercise-induced myalgia, and
protracted myalgia syndrome (PFMS), which differ in
severity of pain, height of fever, and duration of the epi-
sode (22). Unless treated, the PFMS usually lasts for
weeks. In this patient, intensifying the colchicine treat-
ment with anakinra injections helped to rapidly control
In contrast, the motivation for the use of anakinra in
The incidence of HSP in FMF patients is significantly
higher than in the normal population (2). Furthermore,
the occurrence of FMF-associated MEFV mutations is
higher in HSP patients when compared with the general
population (2).
Disease associations of FMF and/or increased carriage
of other diseases, eg, polyarteritis nodosa (2), rheumatic
anakinra treatment in a girl with FMF associated with
Behçet's disease reduced the clinical symptoms of both
diseases (14).
Efficacy and Treatment Modalities
of IL-1 Targeting Drugs in FMF Patients
As case reports are currently the only available source of
information for the evaluation of the efficacy of interleu-
be drawn. Treatment with anakinra (1 mg/kg in children
and 100 mg/d in adults) or canakinumab (usual doses
2 mg/kg/8 wk in children under 40 kg and 150 mg/8 wk
in adults) was beneficial to all of the cases published here
and by others, suggesting that interleukin-1 targeting
ertheless bear in mind that off-label treated patients tend
to be reported only when results are positive. Controlled
trials are now necessary to evaluate the tolerance and effi-
cacy of interleukin-1 targeting drugs in FMF patients.
The duration of the treatment depends on the clinical
indication. In some cases anakinra may be necessary only
for a limited time to manage a difficult clinical situation.
In case 6, for example, anakinra was used for 2 weeks to
treat an episode of FMF-associated PFMS. In most
patients, however, interleukin-1 targeting drugs were
used to control the frequency and/or severity of FMF
ment to prevent attacks or by an acute treatment at the
published cases, anakinra was used as a chronic, daily
treatment. In 1 case, however, anakinra was used punctu-
U. Meinzer et al. 269
Page 6
FMF episode (9). The authors report that anakinra re-
duced the severity of the crises during a follow-up of 6
months, suggesting that in patients with good compli-
ance, early treatment at the onset of the attacks may be
considered. In contrast, in case 4 anakinra had no effect
crises, whereas daily injections induced complete clinical
remission, indicating that daily injections may be more
efficient than treatment of crises only.
Another question is whether colchicine treatment
should be continued or discontinued when introducing
interleukin-1 targeting drugs. In patients with toxic side
effects to normally dosed colchicine, the dose can be ei-
ther reduced or stopped. In case 1, for example, consider-
ing the development of severe neuromyositis, the physi-
in whom interleukin-1 targeting drugs were introduced
because of insufficient control of the disease activity, col-
chicine treatment was continued. This approach seems to
be safer, given the empirical character of treatment with
IL-1 targeting drugs vs the well-documented beneficial
AA amyloidosis.
Safety of Anakinra in FMF and Other Diseases
No reliable data about safety of interleukin-1 targeting
drugs in FMF patients are currently available. In other
diseases, however, including adult rheumatoid arthritis
to be well-tolerated in adults and children (24,25). In the
published FMF cases, local pain and inflammatory signs
at the injection site were the only reported side effects of
anakinra and canacinumab. Even though they tend to be
compliance or complicate the agreement to injections in
pediatric patients (case 7).
The potential risk of infections is a general concern
when using biotherapies. Serious infection in rheumatoid
arthritis patients treated with anakinra was the subject of
a recent meta-analysis (26). The overall pooled Odds Ra-
tio for serious infections did not show a significantly in-
creased risk. However, the risk was increased for a high
dose of anakinra vs low dose, and high dose vs placebo
(Odds Ratios ? 9.63 (95% CI: 1.31-70.91) and 3.40
(95% CI: 1.11-10.46), respectively). When patients with
comorbidity factors were excluded, the results were not
statistically significant whatever dose groups. This analy-
sis indicates a potential risk of serious infections, espe-
cially in patients with comorbidities. The risk of infec-
tions may also be higher in very young children in whom
the immaturity of the immune response is less effective
against polysaccharide encapsulated bacteria (27). By
consequence, from a practical point of view, the existence
tion against Streptococcus pneumoniae should be updated
and in very young children antibiotic prophylaxis during
treatment should be considered. Finally, cholesterol and
triglyceride levels and blood cell counts should be moni-
New Interleukin-1 Inhibitors
In all of the published patients (9-16) and in cases 1, 2,
and 4-7 of this report anakinra was used to target inter-
leukin-1 signaling. A number of other IL-1 inhibitors are
currently in different stages of development, including
the long-acting molecules canakinumab and rilonacept.
Whether long-lasting drugs should be used as a first-line
treatment (case 3), or only after having confirmed the
clinical benefit of silencing the IL-1 pathway with short-
acting drugs, or when compliance problems are encoun-
tered (case 7) needs to be discussed. Long-acting mole-
use and may resolve problems with patient compliance.
However, data on safety and tolerance of these drugs are
currently very limited and their long-lasting effect cannot
be interrupted even when adverse effects occur.
Colchicine treatment is safe and effective in the large ma-
jority of FMF patients. However, the published cases in-
dicate that in some, rare patients the availability of an
alternative treatment would be desirable. The data for the
use of interleukin-1 targeting drugs in FMF patients are
currently limited to uncontrolled off-label use. Alto-
geting drugs may be good candidates when looking for a
treatment alternative to or supplementary to colchicine.
to further evaluate the safety and efficacy of interleukin-1
antagonists in FMF patients.
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text:
Spacing/planting question for 'Emerald Carpet Manzanita'
I bought a quarter-flat of "Emerald Carpet Manzanita" at the Nursurey this afternoon and would like a second opinion on how far apart I should space each little plant. The area I want to plant it in is about 2' wide, between a sidewalk and the south side of my house and about 10' in length. The area currently has a gravel "mulch". I also would like to know if it will be ok to leave the gravel in place.
From what I understand, the plant will get about 1' tall and can get 6' wide when mature. How much space should I leave between each little plant?
Thank you for your help.
Here is a link that might be useful: Emerald Carpet Manzanita
Guess maybe you have already planted this by now :-) While it does spread nicely, it is not the fastest growing plant and if you have a number already (quarter flat = 4 or 5 plants?), I'd just space them out so they are evenly distributed throughout the area to be covered (and not necessarily in a straight line).
FWIW, spacing of groundcovers has no hard and fast rules. Closer spacing typically results in faster coverage but with woody, evergreen plants some crowding may occur. One can always trim, however. More distant spacing just means one has to wait longer for the same effect but it will happen eventually.

subset: commoncrawl


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How Many People Are Infected With HIV Each Day
Here's a taste of what TheBody.com has to offer on this topic:
Get the Facts
Acute HIV Infection...Treating Acute HIV Infection Pros and Cons of Treating Acute HIV Infection The Bottom Line What Is Acute HIV Infection? The amount of HIV in the blood gets very high within a few days or weeks after HIV infection. Some people get a flu-like illness. This first stage of HIV disease is called "acute HIV infection" or "primary HIV infection." About half of the people who get infected don't notice anything. Symptoms generally occur...
Ask the Experts
Swine flu and HIV-infected PeopleAny special precautions that people with HIV should take in the face of swine flu?Are there interactions between HIV meds and swine flu meds?should i get a flu vaccine now if I didnt get one before the winter?
Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS Foundation...keep you posted, OK?Dr. BobSwine FluApr 30, 2009 Hello Dr. Bob. I am asking this question in hopes that you will respond and people will read it. What additional precautions (besides the normal ones) can an HIV positive person take in regards to... Read more »
saliva (Facts for Life: What you and the people you care about need to know about HIV/AIDS )can i catch HIV if my partner "sprays" when he talks and his salive gets in my eye? Also can i get HIV from an infected partners saliva on my anus?
Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS Foundation...newly infected with HIV each year are under the age of 25. Roughly two young Americans become infected with HIV every hour of every day, and many of the people now living with HIV in the U.S. became infected when they were teenagers. Statistics... Read more »
how many people die from HIV in 2008 (HIV/AIDS SURVIVAL)Hi Bob,l am recently infected with hiv and and live in Australia, 36 years old and my hiv specialist told me hardly no one dies of hiv-aids anymore in Australia, he said maybe 10% of pepole with HIV die in 2008 in auz,but people infected in 2008...
Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS Foundation...Hey there Aussie Dude (or Dudette?),How many people die from HIV in 2008? Well, if you are asking how many HIV/AIDS-related deaths will occur worldwide (or in the Land Down Under) Read more »
How long after can Hiv be detectedHI. I've been with my husbsnd for 7 years now and I had a child 3 years ago. When I was pregnant, I had gotten tested for hiv and it came back negative. If i would have gotten hiv from my husband, who was my first when we started,Would hiv...
Response from Ewald Horwath, M.D.
University of Miami School of Medicine...responds to HIV infection by producing antibodies, which are detectable within a few weeks after the initial infection in most people. After 90 days, about 90% of those with HIV infection will develop a positive HIV test.In answer to your... Read more »
Zambia's HIV/AIDS Council Director Urges People to Be Tested on National Voluntary Counseling, Testing Day...voluntary counseling and testing day, which was scheduled for Monday, said the country's testing rates are too low and urged people who do not know their HIV status to be tested, Zambia's The Post reports. Simwanza added that about 1.5... Read more »
Reaching the Right People With the Right Tools for National Black HIV/AIDS Awareness Day...objectives : Improve knowledge about HIV/AIDS prevalence in Black communities. Normalize February 7 as an annual day for individuals, friends, and groups to get tested for HIV. Motivate more individuals to get involved in their local... Read more »
IAC Day 4: Malignancies and People Living With HIV/AIDS...United States, France, Canada, and Romania presented findings on the important clinical topic of malignancies that can develop in people with HIV/AIDS. Scientists from the U.S. National Cancer Institute reported that the rates of so-called... Read more »
Satellite Broadcast: National HIV Testing Day and Prevention for People Living with HIV/AIDS...about National HIV Testing Day and how to participate. Target Audience This broadcast is intended for organizations and individuals currently conducting HIV prevention programs. The audience includes health departments, HIV Prevention... Read more »
Connect With Others
for hiv- people with long lasting symptoms
Posted by Jambasher, 4 Replies...actions that limit the spreading of HIV limit the spreading of HTLV as well luckily, but even then people get infected with HIV every day. Not to scare people, just to make a point. This has devastated the lives of many the life of many many... Read more »
Posted by Anonymous...RID OF THE STIGMA ASSOCIATED WITH HIV. The United Nations Population Fund has declared HIV/AIDS is a young peoples disease. Individuals between the ages of 15 and 24 are infected every 14 seconds. That means a total of 6,000 people a day are... Read more »
HIV Infections ARE RISING!
Posted by bradford, 7 Replies...HIV/AIDS with gay people. Yet men, women and children of every race and religious or spiritual belief are being infected with HIV every day, all over the world! For years, the gay community successfully promoted and practiced safe sex... Read more »
what to eat for HIV/AIDS person?
Posted by Anonymous, 3 Replies...Hi all, I understand that I should eat BETTER... But I really don't know what are the good meals/food for HIV/AIDS people? Any anybody share your experience with me? And what kind exercise do you guys do? I feel my body is very senstive to... Read more »
Resource Centers
Guides for People With HIV


text:
Aubrey Anderson-Emmons Celebrity Watchlist
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Birthday: June 6, 2007, Gemini
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Phil and Claire's decision to reverse their respective "good cop, bad cop" roles throws the kids for a loop. Meanwhile, Jay offers advice to an entrepreneur (Lin-Manuel Miranda) about a dog-training business; and Cameron has a bout with the flu that threat (more…)
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Jay's bond with his dog, Stella, irks Gloria; Phil and Luke take a walk on a tightrope; Claire's good intentions backfire when she tries to teach the girls a lesson; Cameron picks a bad time for a juice fast.
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Ok, I want to be clear, first and foremost, that I am not recommending any substance I may mention here.
I really just want thoughts and opinions. What do you think about the accessibility of legal highs? Whats legal in your area? Do you think there should be more or less restriction when it comes to these substances? And, what do you think about the (lack of) heath information, or viable studies on these substances?
I just recently realized that there is a synthetic cannabinoid. It has apparently been marketed as a "spice".. in different "herbal incence", and "spice blends". Well this chemical JWH-018, is said to stimulate the same receptor in the brain as THC. So if you smoke said "spice blends" they have been said to produce a high... incredibly similar to a marijuana high. I have very stern sources that claim this is very true. It's not only been said to produce a strong "marijuana like" high, that lasts for hours... But it apparently takes very little to do so.
... it's a MARIJUANA-BE :laugh:
A marijuana high, that will pass any drug test, can be fed-ex'd to most states legally... What do you think about that?
I stumbled upon Salvia Divinorum quite some time ago. It became more of "thing" in the United States in the early 90's. Originally it was found in Mexico, used in ritual by the Mezatec natives.
Salvia had always been used to produce hallucinogenic effects. Obviously as a spiritual aid in tribal rituals. But now, after an extraction of the chemical that produces the "high" was created. Salvia is sold reather candidly in headshops everywhere. With concentrations of the extract that go as high as 100x (or higher).
From what I hear.... salvia ingested in the higher concentrates has the most intense of, well, most any drug. It is an experience most people find displeasing and unpleasant... "it bends reality TOO much" -anonymous
Scary that something like that is so easy to access.
I have also heard of LSA,
******LSA (Lysergic Acid Amide)Quote:
Lysergic acid amide (LSA), a relative and precursor to lysergic acid diethylamide (LSD), is found in the seeds of the Hawaiian baby woodrose (Argyreia nervosa) and morning glory (Ipomoea violacea), which can be crushed, eaten, or soaked and drunk to provide a 4 to 8 hour intoxication that is similar to that provided by LSD, though there are reportedly consistent qualitative and quantitative differences (Schultes and Hofmann, 1980).
This LSA is in Morning Glory and Hawaiian Baby Woodrose seeds. Common garden plants. Easy to access. And can produce a psychedelic trip.
How dangerous do you think this is?
Once again... none of these "legal highs" are recommended for human consumption.


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The Camden Police Department (CPD) is looking for a man who allegedly robbed a convenience store more than a week ago. The store is identified in a CPD report as being at the corner of U.S. 521 South and Black River Road.
Kershaw County Sheriff's Office (KCSO) investigators arrested a 35-year-old county man for allegedly sexually assaulting his 17-year-old daughter. In order to protect the victim's identity, the Kershaw County Sheriff's Office (KCSO) is not releasing the suspect's name.
An Elgin man ended up in the hospital after being shot the morning of Aug. 14 by S.C. Highway Patrol (SCHP) troopers in Columbia following a chase on I-20 that ended in Columbia's Five Points district.
(The online version of this story has been updated to correct three errors. A quote in the 22nd paragraph, regarding the support of life partners is now correctly attributed to Gary Parnell and not his father, Gene. Also, the photograph of two firefighters in a training exercise now correctly identifies Gary Parnell on the right instead of his nephew, Trent Henderson. Finally, in the 30th paragraph, a sentence has been corrected to show that there are seven people on shift at any given time, not that there are only seven employees on the Camden Fire Department payroll. The C-I regrets ...
Kershaw County Sheriff's Office (KCSO) deputies arrested two men Tuesday in separate incidents involved knives.
A Lugoff couple got into a fight, allegedly, after a woman dropped her cigarette in a man's car.
Kershaw County's insurance carrier will pay out $110,000 to settle three of five lawsuits filed against Kershaw County Sheriff Jim Matthews. The settlements come as part of a mediation effort earlier this month.
5th Judicial Circuit Alcohol Enforcement Team (AET) Coordinator Ashley Bodiford (center) holds an award of recognition the team received July 25. The Lexington-Richland Alcohol and Drug Abuse Council (LRADAC) presented the Kershaw County AET with the award for contributions dedication of service to preventing access to alcohol by people under the age of 21. The AET employs various environmental strategies to prevent underage drinking and the potential consequences that come from such risky behavior. With Bodiford (from left) are Kershaw County Sheriff's Office Capt. Ed Corey, Kershaw County Sheriff Jim Matthews, Camden Police Department (CPD) Chief Joe Floyd and ...
Kershaw County Sheriff's Office (KCSO) narcotics agents arrested a Cassatt man following a vehicle chase and fight that led to the discovery of a mobile methamphetamine lab in the man's truck. Agents found additional meth-making materials at the residence the man maintains on U.S. 1 in Cassatt.
A Camden man was shot in the leg after he got into a physical altercation with an unknown subject in a gas station parking lot on West DeKalb Street.
Kershaw County Board of School Trustees member Joseph "Joey" Dorton, 46, died in a single-vehicle car crash early Wednesday morning. Kershaw County Coroner Johnny Fellers said Dorton died at the scene. Fellers said the accident was discovered by a passerby just after 2 a.m. Wednesday. He said the actual accident likely took place sometime during the 1 a.m. hour.
Seven years ago, the Camden Police Department (CPD) arrested a man they knew as 24-year-old Ashiko B. Smith. CPD investigators placed Smith ended in the Kershaw County Detention Center and charged him with murder for fatally shooting 41-year-old Walter James Johnson in March 2005.
A Camden woman allegedly threatened the residents of her St. Matthews Road home, standing on the porch with a long metal pipe.
Kershaw County Sheriff's Office (KCSO) deputies arrested a Camden man on drug and weapon charges after looking for another man wanted on a bench warrant.
The Camden Fire Department's (CFD) 17th annual Fire Fest is set for Sept. 29. The event is held each year on the last Saturday of September to kick off Fire Prevention Week in October. The festival will begin with a 9 a.m. parade of new and antique rescue apparatus through beautiful downtown Camden and end at Rhame City Arena on the corner of Broad and Bull streets where all festivities will take place.
Camden's James Leroy Belk American Legion Post 17 recently honored law enforcement officers and firefighters selected by the heads of their respective departments. This year's honorees include S.C. Highway Patrol (SCHP) Patrolman of Year Thomas R. Chrisofario, Kershaw County Sheriff's Office Deputy of the Year Derek B. Robinson, Camden Police Department (CPD) Policeman of the Year Sylvesta Robinson, Camden Fire Department Fireman of the Year Chris Tidwell and Lugoff Fire-Rescue (LF-R) Firefighter of the Year Michael Stanfield. Behind them are their supervisors, SCHP Sgt. Dan Black, Kershaw County Sheriff Jim Matthews, CPD Sgt. Tyrell Coleman, Camden ...
Page 1 of 1
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Jeep will be showing off seven off-road concept vehicles for the 49th annual Easter Jeep Safari in Moab, Utah, which runs from March 28 to April 5.
The Florida Highway Patrol was investigating a fatal accident on Saturday night in Kissimmee, troopers said.
The Kissimmee police SWAT team responded to a home in the area of Sweetbriar Court near Town and Country Drive with a barricaded subject inside on Saturday night, a spokeswoman said.
Shots were fired Saturday afternoon near a pawn shop on Alafaya Trail and Colonial Drive, Orange County deputies said.
A man in his 70s was killed Friday night after he was struck by a vehicle in Cocoa Beach, police said.
A man was shot in the ankle after a fight broke out at a Kissimmee house party early Saturday, an Osceola County Sheriff's spokeswoman said.
The new DeVine Wine & Grill is an oasis for Oviedo's Lisa Cornelius, who often drives to Winter Park for dinner.
With a key committee about to meet, opposition is growing to the notion of replacing the Transportation Security Administration force at Orlando International Airport with privately hired guards.
An executive director of a Muslim youth center charged with inappropriately touching a 15-year-old girl posted bond after spending 12 days in jail, but he was immediately detained by immigration officials.
After recovering from a suicide attempt, prominent transgender performer Danielle Hunter wasn't ready to leave the hospital.
As an argument earlier this month escalated, someone suddenly yelled, "Brim Blood!"
About three years ago I saw Florida Opera Theatre present its first full opera, "The Medium." The one-hour production was staged in the small, unadorned black-box venue of Orlando Repertory Theatre with music director Robin Stamper accompanying on the piano.
Mad Cow Theatre is the recipient of a $20,000 matching gift from an anonymous patron. That means that any donation made to the theater through April 26 up to that amount will be matched dollar-for-dollar by the generous donor.
With ticket demand continuing to be extremely strong for Hank Williams: Lost Highway, the IceHouse has added three more performances: Tuesday, April 14 at 7:30 p.m., Thursday, April 16 at 7:30 p.m. and Friday, April 17 at 8 p.m. Performances of Lost Highway take place at the...
With daylight saving time our evenings are a little brighter. Here are 20 places in Central Florida that are great for al fresco meals.
Trader Sam's Grog Grotto, a much-anticipated lounge being added to Disney's Polynesian Village Resort, will enter its "soft opening" phase on Saturday.
A Wichita woman says she was shocked when her special needs son was asked to remove his letter jacket at school.
Amanda Knox says she's "so grateful to have my life back" after Italy's highest court overturned her murder conviction in the slaying of her roommate.
A former Alabama police officer has been charged with violating the civil rights of an Indian man who was injured during a violent confrontation in February, authorities said Friday.
The dedication of the Edward M. Kennedy Institute for the United States Senate will be a topic on the Sunday morning programs.
Two South Florida cities rank in the top 25 most overpriced cities in the U.S. for 2015.
ST. AUGUSTINE, Fla. — For the oldest town in America, St. Augustine has sure come a long way in recent years. The town of 14,000 on Florida's northern Atlantic coast celebrates its 450th birthday in late summer, but locals mostly have been rejoicing over the town's cultural growth.
A chance to meet the human and animal stars of "Dolphin Tale 2" and an event geared for car lovers highlight new Florida attractions for the month of April.
The world's largest cruise company wants to get even bigger.
View our gallery of photos sent in by readers and printed in the Orlando Sentinel. Please mail your picture and caption to Your Best Shot, Orlando Sentinel, 633 N. Orange Ave., MP-240, Orlando FL 32801; or e-mail your photo information, with the picture attached as a .jpg file, to...
With a new offer from Medieval Times, two people can see jousting and sword fighting for the price of one.
The Orlando Magic named Tobias Harris and Victor Oladipo co-winners of the 2014-15 Rich & Helen DeVos Community Enrichment Award on Saturday night — an award that honors a Magic player or players for outstanding community service.
They didn't want to leave the court.
Just like the Orlando's shifting weather, fans should expect some changes to the UCF football depth chart this spring.
MONTREAL — Orlando City defender Tyler Turner took a second to look around and let the moment sink before the opening whistle sounded.
In what I call "sports numerology," my favorite sports number is "elite eight." It just sounds cool.
An adult international traveler who attended a conference in Kissimmee had measles, the Florida Department of Health confirmed Thursday.
The EPA issued a health advisory for four Tampa Bay area beaches with high levels of enterococci bacteria.
Seminole county is the fourth healthiest county in Florida, and Orange, Osceola and Lake counties rank in the top third of the state's 67 counties, according to the annual County Health Rankings, released on Wednesday.
Dr. Phillips Charities will break ground this summer on a $75 million senior-housing and health-care project off Dr. Phillips Boulevard in south Orange, according to an announcement.
There was a slight uptick in the number of TB cases in some Central Florida counties, including Orange, Lake and Osceola, between 2013 and 2014, opposite the downward trend in Florida and United States.
Auto dealerships are looking for ways to make it more pleasant to bring in your car for service.
The growing tourism industry and other job sectors made Orlando the leading metro area in Florida for job growth in February, according to a new state jobs report released Friday.
WASHINGTON — Florida is projected to become the first state in the nation to close the wage gap between men and women — but it will take more than two decades.
Hundreds of property owners in some of Orlando's most sought-after areas could soon face new limits on what they can build, as part of an effort by the city to keep out duplexes that officials describe as "out of character" with their surroundings.
The Federal Trade Commission has accused Longwood auto dealer Cory Fairbanks Mazda of false advertising in a national sweep of the industry.
Jeep will be showing off seven off-road concept vehicles for the 49th annual Easter Jeep Safari in Moab, Utah, which runs from March 28 to April 5.
The closing date for the Richard Petty Driving Experience and the Exotic Driving Experience at Walt Disney World has been extended for more than a month.


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Photo: Jennifer Pritchard • MCT,
We are officially in that skinny season between winter and the season called "road repair." During this period, we residents of the North perform the "removing all memories of winter from our vehicles" ritual — putting coffee-can heaters and mismatched gloves far from us. Recently, I joyfully removed such artifacts from my minivan and other family vehicles.
Most sacred of these items is the emergency heater — a lidded coffee can containing a fat candle, waterproof matches and emergency chocolate. I've never needed said heater, but it was a hard winter — there was no chocolate in the can. My husband, a native of the North, rolls his eyes (politely) and assures me that he's never needed a coffee-can kit in 50 years, which is a really long time. But he doesn't understand chocolate emergencies. And he wasn't crawling east on Interstate 94 during Thanksgiving 1983, passing vehicles stranded on the closed westbound side. These cars were filled with people desperate for chocolate and heaters; I'll never forget their faces. Plus, I hear people in Atlanta would have paid big money for a coffee-can potty when stranded for 18 hours this winter. The coffee-can tradition shall continue in our fleet.
Other artifacts included:
• Black plastic bags and rubber bands, which can be fashioned into boots. This was quite the fashion statement when a friend and I took our kids on a sledding expedition when we were unexpectedly snowbound in Idaho.
• The sleeping bag. Once when we slid off an icy Kentucky road, five of us huddled under a sleeping bag and marched to stay warm until the wrecker came. We also tied some donation-bag blouses around our heads. And sang. This was before YouTube.
• Knee socks, which can be used for mittens. Or as socks at a fast-food playland that mandates foot coverings. It's been a while since I've hauled playland-crazed kids, but I say, "Have the socks and they will come."
• Real boots, which, it turns out, are generally in the vehicle when needed for wading from the house (like this April, when the Twin Cities was gifted 6 to 12 inches) and generally in the house when needed for wading from the vehicle.
• The collapsible shovel and kitty litter, for use when we get stuck trying to crash through the plow's snow wall at the end of the driveway. Nice neighbors actually work better than these supplies do for getting unstuck, but neighbors don't do well stored in the vehicle for long periods.
• Missing gloves. Stocking hats.
• Abandoned coffee mugs, snack containers, books, magazines and papers. (Yippee! Found the missing library book!)
• Miscellaneous. A fake potted plant. (Really?) The missing mop. The missing large bag of baking soda. Hair thingies.
• A sack of clothes to donate. Hmm. Waiting to see if we needed blouses to tie around our heads?
• Fossilized french fries.
This was going to be short. But the list kept getting longer, kinda like the winter of 2013-14. Now, on to dealing with our winter coat collections.
Julie M. Evans, a public-relations consultant and native of Kentucky, has survived 22 Minnesota winters. She blogs at www.juliemevans.wordpress.com.
The Opinion section is produced by the Editorial Department to foster discussion about key issues. The Editorial Board represents the institutional voice of the Star Tribune and operates independently of the newsroom.
Poll: Do you agree with Gov. Dayton that Wisconsin's tourism ad is 'idiotic'?


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XFINITY TV Go
5,000,000 - 10,000,000 downloadsAdd this app to your lists
+ By Comcast Interactive Media
XFINITY TV Go lets you:
• Watch your favorite sports, news and kids networks live.
• Stream TV shows and movies from premium channels like HBO, Starz, Showtime, Cinemax and networks like ABC, FOX, NBC, TNT, TBS, Cartoon Network, A&E, AMC, WETV, Food Network and HGTV
• Download TV shows and movies from Showtime, Streampix, Starz, Encore and MoviePlex and watch them when you're offline.
• Set parental controls for privacy and peace of mind.
• Wi-Fi internet connection for streaming and download of video
• Android phone or tablet running Android 2.3 and higher.
• XFINITY TV or Comcast Digital Video service. You will also need a subscription to one or more eligible channels to play content.
• Comcast ID or Comcast.net email address and password.
Streaming and downloading of video is not available internationally.
Get Help Signing-In!
• Create a Comcast ID --> https://login.comcast.net/myaccount/create-uid
• Look up your Comcast ID --> https://login.comcast.net/myaccount/lookup
• Retrieve your Comcast ID Password --> https://login.comcast.net/myaccount/reset
**** Explanation of permissions requested:
* permission.INTERNET - Access the Internet.
* permission.READ_PHONE_STATE - We use the ID of your phone to prevent playback abuse.
* permission.ACCESS_WIFI_STATE - We tune playback if you are on WiFi.
* permission.ACCESS_NETWORK_STATE - We detect connectivity before allowing playback.
* permission.WRITE_EXTERNAL_STORAGE - We cache browse images to your sdcard to save your bandwidth.
* permission.WAKE_LOCK - We prevent your device from sleeping during playback.
* permission.WRITE_SETTINGS - Used if you enable our advanced brightness and volume controls for use during playback
* permission.RECORD_AUDIO - This version includes experimental support for voice-guided navigation
Tags: xfinity tv player apk, xfinity tv go apk, xfinity tv apk, xfinity player apk, xfinity tv player app apk, xfinity go apk, comcast anyplay, xfinity tv app apk, xfinity tv go app apk, xfinity tv go.apk.
Fixes an issue where video quality would not adjust to sudden drops in bandwidth, resulting in excessive buffering.
Some lists where this application appears: Media.
(66 stars)
I had an issue with my cable being weird and I go on TV go and I can watch what I need! It's literally the best!
(66 stars)
(66 stars)
It is easier to use than on demand. With a smart tv or my tablet, I use it for much of my TV time.
(66 stars)
Wish it was Chromecast compatible...
(66 stars)
Total Awesomeness
(66 stars)
This app doesn't have all the shows on it I thought I would be able to watch all the shows I missed or can watch while I am away...that is a negative. You need to give us access to All the TV shows that go I with what we pay for.
(66 stars)
Great app


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Chain won't turn on a Poulan Wild Thing Chainsaw
I recently bought a Poulan Wild Thing chainsaw, and I tried to use it for the first time tonight. I put SAE 30 oil in it and the 40:1 gas/oil mix. I got it to start, but when I tried to engage the chain, it would not turn. I didn't see anything in the manual about first time starts or specifics about the chain, so I'm not sure what's happening. I'm afraid to keep trying because smoke appears like something's burning. Any help our thoughts would be great.
Can you move the chain by hand? Is it a new saw? And of course as suggested by baymee took the brake off right? If the brake is off and the chain won't move by hand (wear a glove when trying to move the chain) the chain maybe pinched and locked up or the clutch drum is locked up either by the brake or the chain/bar adjustments. Now if it don't turn now would be a good time to figure out how to remove bar and chain. Inspect the clutch drum, install and adjust the chain tension and of course make sure the chain is in the bar correctly. With that saw you will have to clean, sharpen, and adjust the chain about after ever use anyway if you want it to last and cut right.


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Woman's Elana Argentinian Leather Handba
By Ly-Ly
from Pittsburgh, Pa. 15206
Comments about Women's Elena Argentinian Leather Handbag:
This is the best bag I've ever owned! I usually go for the designer bags but this time I was smart and when for quality! Can't be beat for looks, quality and usefulness! Be visiting U soon again!
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great bag
By deb who roams
from st. louis
have been using for over two months. lovely leather, love the twotone, lots of pockets. very comfortable to carry, can hold quite a lotof items, yet looks great.


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by drifter51 May 06, 2009
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Miss Rhythm" Years before Aretha Franklin was crowned Queen of Soul, Ruth Brown reigned as the Original Queen of R&B. She achieved a distinct style, sassy and streetwise, which made her one of the more influential singers of her era. Ms. Brown sustained … see full wiki
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Born Clyde Lensley McPhatter on 11/15/32 in Durham, North Ca …


text: |The story in this book is incredible but true. It is about secret societies, how they have directed the course of civilization and how they influence your life today. Most people don't realize they exist because their minds have been conditioned to reject any thought of such organizations. In this book, Dr. Monteith reveals the amazing facts he discovered in his almost 40 years of research. He reveals the identity of the mysterious forces behind the men who rule the world and why some of our leaders have dedicated their lives to destroying our nation. After reading "Brotherhood of Darkness," you will never look at the world the same way again. Type: Paperback () Category: Books > Philosophy ISBN / UPC: 9780981764375/0981764371 Publish Date: 2/1/2009 Item No: 95016 Vendor: Anomalos Publishing LLC/ Defender Publishing Group


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Supervisor Breed Calls for Removing Some of SF's Parking Mandates
Supervisor London Breed has proposed a "Parking Flexibility Ordinance" that would make it easier for building owners and developers not to build car parking when it would impinge on the street environment for walking, bicycling, and transit. It would also count parking spaces against density limits, unless they're built underground.
The ordinance [PDF] was approved by the Planning Commission last week and is expected to be approved by the Board of Supervisors in the coming weeks.
SF's 1950s-era parking mandates increase the cost of building housing and limit the space available for apartments, storefronts, and other uses. Minimum parking requirements encourage car ownership, make buildings more susceptible to earthquake damage, cut up SF's sidewalks with driveways (which also reduce street parking and encourage sidewalk parking), and diminish the pedestrian realm with blank garage doors.
The proposal would amend the planning code so that "builders, businesses, and homeowners can have more say in where and if they put parking on their property," Conor Johnston, an aide for Breed, told the Planning Commission Thursday.
Breed's proposal would waive parking mandates in certain situations, including when parking spaces require drivers to cross a curbside bike lane, transit-only lane, or a sidewalk that's at least 25 feet wide. The additional flexibility will allow existing parking spots to be converted to other uses and let developers forego building new ones.


text:
Hacking suspect a 'genius,' but often in trouble
Already a rock-star to anarchists and cyber-terrorists worldwide, Hammond was one of five computer hackers charged Tuesday with crimes related to high-profile cyber attacks against major corporations and government entities. Court documents tie Hammond to "Anonymous," a decentralized international collective of "hacktivists," or people who use computer networks for political protests and other actions.
His mother, Rose Collins, offered a heavy sigh when informed that the FBI had arrested her 27-year-old son.
"Again?" she asked. "I love my son, but he is a genius with no brain. He has a 168 IQ, but he has no wisdom."
Hacking suspect a 'genius,' but often in trouble
A cheap and fully optical solution for ultra-fast internet
Supported by EUR 2.6 million in research funding from the European Commission, the project not only demonstrated connection speeds of up to 10 Gigabits per second (Gbps), around 2,000 times faster than most Internet users experience today, but the researchers showed that such speeds can be achieved at relatively little extra cost using existing fibre infrastructure and off-the-shelf components.
A cheap and fully optical solution for ultra-fast internet
Hands-on with the iRobot Roomba 780: My belated first date with a floor-sweeping robot
The Roomba arrived in my two-bedroom, 800-square-foot Brooklyn apartment about two weeks ago, and I'll tell you, this thing comes armed to the teeth with impressive sounding features.
We're talking optical and acoustic sensors that literally look and listen for dirt and debris; ultra-fine filters that catch particles of dust less than a micron across; redesigned motors and cleaning heads that are less likely to get snarled with pet or human hair; and a roomier bin that collects more dirt, debris, and gunk than any previous Roomba.
Hands-on with the iRobot Roomba 780: My belated first date with a floor-sweeping robot | here's the thing
The future of weight loss: A 'marijuana' diet pill?
If you find the prospect of staying thin while eating as much as you want appealing, scientists have news for you. New research from the University of California, Irvine — detailed in the March issue of Cell Metabolism — found that certain brain chemicals with characteristics similar to marijuana might play a key factor in helping you shed pounds without any exercise. A dream come true? Here's a brief look at the promising discovery:
The future of weight loss: A 'marijuana' diet pill? – The Week
Cel mai de succes SISTEM BANCAR din lume: cel creat de Mohamed
Un sistem bancar ferit de crize, creat la umbra Coranului
Sistemul bancar islamic se deosebește de sistemul bancar occidental prin faptul că debitorii sunt obligați să investească în firme cu acoperire în realitate, fiindu-le interzise speculațiile financiare. Orice capital varsat trebuie să aiba legatura cu bunuri reale. În acest fel băncile sunt ferite de așa-numitele "bule speculative".
Unele sectoare ale economiei sunt exluse din activitatea băncilor musulmane. Ele nu creditează firme care produc sau distribuie alcool, produc, procesează sau vând carne de porc.
De asemenea, băncile islamice nu dau bani pentru investiții în industria pornografică sau de armanent doar pentru simplul fapt că sunt interzise de Coran. În principiu, băncilor musulmane le este interzis să dea bani pentru activitati care contravin interesului religios..
Cel mai de succes SISTEM BANCAR din lume: cel creat de Mohamed – Actualitate > Capital.ro
Zotac ZBOX ID80 Plus Mini-PC Review
This is where Zotac, as one of the world's premiere manufacturers of SFF PCs with their ZBOX line, offers their latest creation: the ZBOX ID80 Plus.
Zotac ZBOX ID80 Plus Mini-PC Review-Hi Tech Legion-Zotac ZBOX ID80 Plus Mini-PC Review
Super Talent prepare RAIDDrive upStream PCIe SSD for consumers
Super Talent displayed a new PCI-e based flash storage system at CeBIT that it plans to release to market by the end of April. Dubbed the RAIDDrive upStream, it promises to deliver superior performance to that of conventional SSDs but will cost less than existing PCI-e products from the company.
Super Talent prepare RAIDDrive upStream PCIe SSD for consumers by VR-Zone.com
- Why food is rarely the simple pleasure it once was
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text:
The Brown Deer Police Department is looking for help identifying a suspect in at least seven entries to autos and thefts from autos.
According to a BDPD news release:
At 1:10 a.m. on Nov. 20 the suspect gained entry into the Northpointe Apartments, 9418 N. Green Bay Road in Brown Deer. He rang multiple doorbells until he was let into the secured lobby. The suspect then went into the underground parking area and let in a second subject in a vehicle. Multiple cars were entered, damaged, and items were stolen. The two left in the vehicle together.
The first suspect is described as: Black male late teens to early 20s, 5'8" to 5'11" with a slim build and short black hair, wearing a black hooded Adidas zipper sweatshirt with white stripes on the sleeves, tan pants, and bright pink Adidas tennis shoes.
The second suspect was not described.
The vehicle the suspects left in is described as an older model (1999-2000) silver Nissan Maxima four door with possible front hood damage.
Photos of the first suspect and vehicle are available here: http://media.jsonline.com/documents/Theft+From+Autos++-+Northpointe+Apartments+11-20-12+at+0135.pdf
Anyone with information regarding the suspects is urged to contact Lieutenant George King at (414) 371-2900.
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|Jan 28, 2013, 01:36 PM
Joined Jan 2013
1 Posts
I write from Argentina (This is a translation of google)
Asked about MicroPitss data.
I would appreciate me showing:
- Wingspan
- Weight at flight
- Electronics used (receiver - servos, etc..)
- Engine
Thank you very much!
|Jan 30, 2013, 09:33 PM
Here are the infos, I can give you.
- Wingspan : 12 inches (30,5 cm)
- Weight of flight : 25-30 gr.
- Electronics used (receiver - servos, etc..): originally built for the RFFS system, not sold anymore, I think.
- Engine: originally the KP-00 with a U-80 prop
For electronic and engine, a lot of new stuff went out during the last 10 years when the plan was drawn.
Here is the plan and instructions.
Do a google search on Chris O'Riley Micro Pitts and you will find info and setup. Good luck.
|Feb 13, 2013, 01:38 PM
I'll be scanning the thread as I get the chance, how feasible is it to build this from meat tray foam and AS3X spitfire guts? Maybe use a plastic bottle shrunk over a wooden form for a cowl?
|Feb 13, 2013, 09:24 PM
|Feb 14, 2013, 06:43 AM
Gulf Breeze, FL
Joined Jul 2006
3,273 Posts
However, the meat tray foam is great for tail surfaces since it's generally stiffer than modeling foam.
As for the plastic cowl, shrinking a plastic bottle will work, but will take a lot of effort. You may be better off just carving some foam, blue or otherwise, and finishing it with something like layers of lightweight fibercloth using Minwax .. or just Epoxy.
I'd sure follow FLB's advice and scale it to around 16 in wingspan if you're contemplating heavy Spitfire gear. Two mm Depron would be a good choice for foam - certainly there are many sources on-line like RCFoam or locally through stores like HobbyLobby.
Gene K
|Feb 14, 2013, 07:39 AM
Primary foam I have available is Dollar Tree and Model Plane Foam, both of which are roughly 6mm, too heavy for this sort of thing. The trays I've picked up thus far are roughly 8x12 and required sanding to take molded grid out, there are larger ones.
I also have some UMX Extra 300 guts available, those may be lighter. End of the day the quest is to cheaply turn old airframes broken on the shelf into viable indoor flyers very cheaply.
Which Hobby Lobby? The RC or craft store? If I can find Depron in a brick and mortar (or WARM show) in central NJ I'll grab some, I'm intentionally limiting credit card abuse after a recent spending spree, cash and carry rules.
Hmm actually hitting rcfoam for the 10 pack of 10" x 30" 2mm white depron for $8.00 isn't bad, depending on shipping. It's when you go to bigger sheets or stuff like EPP it starts to add up. Also don't want to stock up on foam and then not continue to build and just have it collect dust.
|Feb 14, 2013, 03:07 PM
Gulf Breeze, FL
Joined Jul 2006
3,273 Posts
As concerns RCFoam - their prices are very good, but shipping runs around $10 for a small order ... and around $10 for a large order. So unless you go in with someone for a larger order, it may be too expensive for you (hint .....
Gene K
|Feb 20, 2013, 06:50 PM
Somerset Pa
Joined Dec 2009
176 Posts
I think I may have to build one now, thanks for sharing the plans
|Feb 20, 2013, 11:04 PM
Joined Nov 2000
7,557 Posts
Erm.. You could use Balsa ??
The original Chris O: Micro Pitts and Micro Moth was intended for balsa.
Wayy stronger than foam too, for miniscule weight disadvantages.
As there isn't that much material used and while Balsa is somewhat heavier one uses it in Very thin sheets and bits.
|Mar 11, 2013, 10:48 AM
Joined Nov 2011
299 Posts
I'm looking into getting into planes again. Back 10 years ago I used to fly but now the tech is so obsolete I might need new radios and receivers. Meanwhile I was into helis but getting a Pitts is like a childhood dream.
So I was wondering with different equipment. Basic setup would be about 120USD and that would be an orange HK transmitter with a AR6400 (or similar brick) or then getting a Turnigy 9x radio with a JR module for the SuperMicro Systems brick. The turnigy and orange setups are in pretty similar price ranges.
As you can see I'm trying to assemble the cheapest way to get a decent setup. Is this an OK direction? I haven't got the funds to invest in much more expensive kit so after a bit of google'ing this is what I came up with.
|Mar 11, 2013, 01:20 PM
|Mar 11, 2013, 08:59 PM
Joined Nov 2000
7,557 Posts
IF $ is a concern: Hunt around.
Bargains are out there. I recently bought (at a swap meet) Five! Radio systems for $15 ..Futaba and JR ..decent/recent computer type ones too.
All with their plastic protector films still on. Clearly lightly, if even, used.
Current Mad rush for the 2,4 bandwagon has rendered what were Primo units.. obsolete and apparently worthless.
If in possession of one of the non 2.4 systems ...one can buy ($20) and retro fit a FrSky 2.4 ghz module to virtually ANY (including AM ones) Tx and buy the accompanying FrSky receiver with full telemetry ~ 9$/12$ . Unlikely a Teeny Tiny model would have needs of temetry.. But the Frsky system is a Tech marvel as the point being made.
HK also sells those wee Fragile linear servos just like the Spektrum on board ones.... If you must.
Tiny but slightly weight increased servos can give genuine advantage, IF your model is just that tiny bit larger needed to ably deal with them.
Again; Lots of ways to the same destination and the ticket prices can vary dramatically.. shop around :-)
|Mar 12, 2013, 12:46 AM
Joined Nov 2011
299 Posts
Thanks for your help guys! If some of you fly it with only a rudder, elevator and throttle do you think I could make this work? I fly my micro helis a bit and I've got these bricks readily at home:
The WL Toys V911 PCB. It's 5g and 4ch (fourth channel is for the rudder of the heli so couldn't be used for this heli).
The only thing I'd need to buy would be maybe a parkzone motor/gear/prop assembly? Of course this would be a test plane but still fun though?
|Mar 14, 2013, 04:03 PM
United Kingdom, England, Redcar
Joined Jan 2006
3,409 Posts
They will work fine as long as you are careful regarding the motor ,im building a few small planes and trying to base them around this board and the nineagles motor/gearbox , the basic options you have with them is rudder/elevator or elevator/aileron.
|Mar 15, 2013, 11:11 AM
Joined Nov 2011
299 Posts
What's the main difference between either rudder/elevator or aileron/elevator? Sounds like turning should be easier with just the rudder, also more basic. Is the aileron/elevator combo (without rudder then) more difficult to fly? Should I build it with the rudder or ailerons then?
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Dr. Gilbert H. Lee, MD
Family Medicine
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Riverside, CA 92518
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Dr. Gilbert H. Lee graduated from the Loma Linda University School of Medicine in 1988. He works in Riverside, CA and specializes in Family Medicine. Dr. Lee is affiliated with Kaiser Permanente Riverside Medical Center.
Gender: Male
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Family Medicine
Medical School: Loma Linda University School of Medicine; Graduated 1988
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Posted by TheLaughButton 8 hrs ago | google.com
Guy Branum is a writer and comedian best known for his recurring segment "No More Mr. Nice Gay" on Totally Biased with W. Kamau Bell, serving as "Staff Homosexual" on Chelsea Lately and his performance as Natalie Portman's sassy gay friend in No Strings Attached. ... [Read More]
Posted by TheLaughButton 8 hrs ago | google.com
The Birdman, Michael Keaton, hosts Saturday Night Live with musical guest Carly Rae Jepsen on April 4. Here are his promos alongside Cecily Strong. SNL host Michael Keaton gets robbed in his promos with Cecily Strong appeared first on The Laugh Button.... [Read More]
A special one night only screening of Bill Hicks' Relentless to be shown in movie theaters on April 27th
Posted by TheLaughButton 9 hrs ago | google.com
We previously reported that Comedy Dynamics has plans for the re-release of the late, great Bill Hicks entire catalog of work. Another piece to that already incredible puzzle was announced today as for one night only on April 27th they will also show a screening of Hicks' iconic special Relent... [Read More]
Posted by SplitSider 9 hrs ago | splitsider.com
by Megh Wright Wompler fans, rejoice, because Earwolf has some big news. The podcast network announced today that Jessica St. Clair and Lennon Parham are set to debut their brand new bi-weekly podcast Womp It Up! on Monday, April 20th featuring the Playing House stars as their beloved Comedy Bang! B... [Read More]
Posted by TheLaughButton 10 hrs ago | google.com
Trevor Noah joins executive producer Steve Bodow and writer Jo Miller for a conversation about Trevor's comedy roots in South Africa and the international perspective he brings to The Daily Show. You can listen to the podcast in it's entirety here. The Daily Show Podcast introduces you t... [Read More]
Posted by TheLaughButton 10 hrs ago | google.com
Patton Oswalt took to Twitter in a fake outrage tweet storm in support of Trevor Noah, your new host of The Daily Show. If you weren't already aware, comedian and correspondent for The Daily Show has come under fire in recent days after the announcement came down that he would be succeeding Jo... [Read More]
Posted by SplitSider 10 hrs ago | splitsider.com
by Phil Davidson Joe List is the comedy underdog everyone seems to root for. A longtime fixture in the New York comedy scene, List had the reputation as the gifted standup comic who could never catch a break. But to paraphrase Seinfeld, a List obsession, 2015 could be the Summer of Joe. After a kill... [Read More]
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by Megh Wright Today is April Fools' Day, the one day of the year when the internet is so infested with tricks, pranks, and lies that the only way to avoid getting scammed is to stay offline altogether. Fortunately, Reggie Watts has created the perfect safe space where you can come and relax in a co... [Read More]
Royal Mail stamps feature comedy legends to celebrate April Fool's Day including Monty Python and Billy Connolly
Posted by TheLaughButton 11 hrs ago | google.com
News from across the pond can now be sent using a first class stamp featuring on the Britain's finest from the world of comedy. Royal Mail is marking April Fool's Day by issuing a set of stamps featuring some of the nation's most popular, and funniest, comedians. Pho... [Read More]
Posted by SplitSider 11 hrs ago | splitsider.com
by Megh Wright Indiana has been making headlines for the awful discriminatory "religious freedom" bill they passed last week, so during last night's Conan, O'Brien reached out to Indiana's very own self-appointed religious freedom czar Don Beederman for more context. Beederman has conducted extensiv... [Read More]
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Rust This World turned Marvel Super Hero Squd figurines into an entire line of Super Smash Bros. toys.
*Buy Metroid toys at eBay.
Monday, December 13, 2010
Super Smash Bros. figurines
Posted by John at 5:22 AM
Labels: custom toys, metal gear, metroid, nintendo, toy, video games
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Red, White & You!
Workforce Solutions Upper Rio Grande
Thursday, November 15, 2012 from 9:00 AM to 1:00 PM
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
Calling all Veteran Job Seekers!
Join Workforce Solutions for the Hiring Red, White & You career expo designed to connect Veteran job seekers with employers looking to hire you!
This event, geared towards hiring Veterans, is on Thursday, Nov. 15th, at our Downtown Norman Haley Employment Center, located at 300 East Main, El Paso, Texas 79901 from 9:00 am to 1:00 pm.
There will be 75 companies and over 1,000 job opportunities!
Please bring copies of your resume and remember to dress to impress.
If you are an employer looking to hire veterans please contact Oscar Licon at 915.243.3920 or by email at email@example.com
When & Where
Norman Haley Employment Center
300 East Main
El Paso,
Thursday, November 15, 2012 from 9:00 AM to 1:00 PM
Add to my calendar
Workforce Solutions Upper Rio Grande
Ticket to Success workshops will begin January 20 to February 13, 2015 and are held 2 hours a day/four days a week at your local workforce center. Classes available Tuesday-Friday at 8 am -10 am or 4 pm -6 pm.
Ticket to success workshops focus on resume building and writing, mock interviews and techniques, dressing for interviews, skills for workplace success, and personal financial literacy.
For more information call: (915) 887.2600
Workforce Solutions Locations:
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Amazon offers unlimited cloud storage plans
It used to be that users were already satisfied with getting 1 or 2 GB free from cloud storage services. But with the amount of media and data files that we collect everyday, mobile users are now looking for those that will be able to offer more than that. Some still go for free storage, but others are now willing to pay given the right incentive and also given the right, trusted brand. Amazon is a name that most people willingly share their credit card info with on a regular basis so it should be right up their ally.


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Are you a true beauty products addict who would love the opportunity to learn how write about your obsession for a living? Apply for a summer internship at award-winning beauty blog Beauty Binge! You will pitch and write beauty blog posts (yes, you will also get a lot of free beauty products), organize beauty products, edit the blog, own social media process, etc. This position requires a very strong writer and someone who is insanely hard-working and detail-oriented (OCD preferred). The good news? You will have the chance to work from home at least 1-2 days a week.
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Investment income for the third quarter of 2008 was $0.3 million, a decrease of $1.9 million or 84%. This decrease was primarily attributable to a decrease in dividend and interest income on lower cash, cash equivalent and investment balances and lower yields earned on these investments.
Nine months ended September 30, 2008
Total revenues for the first nine months of 2008 were $2.1 million, a decrease of $10.0 million or 83%. This decrease was due to lower product sales of Oxandrin and oxandrolone, as a result of generic competition and from an increase in our allowance for product returns resulting from a rise in our actual historical product return rates. Cost of goods sold was $0.9 million for the first nine months of 2008.
Research and development expenses were $37.8 million, an increase of
$1.6 million or 4%. This increase was primarily due to higher
manufacturing-related expenses related to technology transfer to our
secondary source supplier of pegloticase active pharmaceutical ingredient
(API), increased outside services expenses related to our BLA filing,
higher compensation and share-based compensation expenses due to an
increase in employee headcount for manufacturing and medical affairs
activities, an increase in the quantity of certain performance-based and
service-based restricted stock awards and higher expenses for toxicology
studies for pegloticase. Partially offsetting these increases was a
decrease in clinical trial costs as our Phase 3 clinical trials for
pegloticase were completed in late 2007, a decrease in manufacturing
process development and validation expenses, as the majority of this work
was completed in the prior year and lower expenses related to the
reservation of manufacturing ca
|SOURCE Savient Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
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News from the USC Retiree Community
Tips to "Successful Aging" – A Guide to What's Next … and What's New
March 16, 2015
Ten Tips to "Successful Aging"
Well-being, Fulfillment and Joy: For Today and Tomorrow
On March 12, 2015, Helen Dennis, Author and Specialist in Aging, Employment & the New Retirement, conducted a special seminar for retired faculty and staff to challenge their thinking and possibly modify or enhance their lifestyle.
Click here for a copy of the PowerPoint Presentation Continue reading
Emergency Preparedness Symposium
March 10, 2015
The USC Emeriti Center held an Emergency Preparedness Symposium on Friday, February 20th. The sessions provided information and guidelines to prepare for emergencies with special focus on seniors, their caregivers and those with disabilities. View video recordings below.
Earthquake Preparedness, Captain John Ignatczyk, Los Angeles City Fire Department Disaster Preparedness Unit
Fire Safety in the Home, Firefighter Susan Jensen, Los Angeles City Fire Department, Emergency Preparedness Division
Fall Prevention, Anat Louis, Department of Aging Continue reading
iPad Overview for Seniors
February 25, 2015
iPad Overview for Seniors
The Emeriti Center hosted an iPad workshop for seniors on Friday, February 27th. For a copy of the handouts, please contact the USC Emeriti Center at 213-740-8921. Continue reading
Upcoming Events
Life After Retirement
Dr. Robert B. Kaplan
As long as health permits, retirement for Robert B. Kaplan means keeping busy. He has been lucky and enjoys good health. In 1998–99, Bob had the opportunity to serve as Visiting Distinguished Professor of Applied Linguistics at Meikaiu University in Japan. He … Continue reading
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The nuts and bolts
- Printed foot bed with Quiksilver Summer 13 boardshort graphics
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Reviewed by 1 customer
- Comfortable
- Lightweight
- Stylish
Best Uses
- Beach
- Casual Wear
- Outdoors
Comments about quiksilver Boys 8-16 Foundation Cush Sandals:
All around solid sandal. My son loves them.
- Sizing:
- Feels true to size
- Width:
- Feels true to width


text:
Part 3 of Advancing the Kingdom-
Stating focused is key to disciplining the nations. Boldness is required to continue the message of the Kingdom.
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"A Connecticut town we enjoy visiting often" Top 5 Page for this destination Milford by Gypsystravels
Milford Travel Guide: 93 reviews and 257 photos
Milford has become a town that Ferni and I spend quite some time in. It is conviently located off of I-95 and about 25 minutes from our home. It is a really nice town along the Long Island Sound and we enjoy walking around the down town area, stopping at a few restaurants and bars to grab something to eat or drink as well as a bit of shopping.
Downtown Milford is quite small, and you can easily spend an hour and cover most of it. There are a few scattered bars/restaurants and shops. One of our favorite places to grab a drink is at SBC where we hang out at the bar, chat and watch a sports game on one of the tvs. The downtown area is particularly nice and there are a host of different fesitivals that take place here as well, like the Oyster Festival. There are a couple of war memorials dedicated to the Vietnam, Korean and WWII wars. Here is where you will also find the Stonebridge, a landmark in Milford. There are a few lovely parks as well as the Milford Marina where you can sit and enjoy an ice cream treat from Dip Top as well as the lovely Hotchkiss Bridge.
We also like to drive along Route 1 in Milford where there are plenty of places for us to grab a bit to eat or drink. The shopping at the Westfield Shopping center as well as many of the other shopping centers is like many other we go to with some of our favorites shop. We also enjoy the movie theatre here as well, it's one of our favorites.
Reviews (32)
Bertucci's is a great place to grab a good meal whether for lunch or dinner. There are quite a few locations and it's a... more travel advice
Ferni and I enjoy coming here. We like their friendly atmosphere, wide selection of drinks and beers and their food is... more travel advice
Ferni and I have come here quite a few times, most recently to watch a football game but even after catching a movie... more travel advice
Ferni and I have frequented the Black Bear Saloon in Norwalk many times and during our shopping jaunts here in Milford... more travel advice
Hotels (3)See All A Great place to stay during our road...
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Shopping (6)See All I enjoy their holiday scents
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The Jefferson County Sheriffs office is reporting that police were called to the Pizza Hut at 1310 West Burlington early Sunday morning.
Keywords: Attempted Robbery, Fairfield, Pizza Hut
A bipartisan effort in Kentucky is moving to treat drug addicts rather than jailing them. Is this a good idea?
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