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Publications (147)260.27 Total impact
Article: Trends in Susceptibility of Escherichia coli from Intra-abdominal Infections to Ertapenem and Comparators in the United States: SMART 2009-2013.[Show abstract] [Hide abstract]
ABSTRACT: Antimicrobial resistance in Enterobacteriaceae, including to carbapenems, is increasing worldwide. However, using 2009-2013 United States SMART data, no statistically significant decreasing susceptibility trends were found for Escherichia coli overall from patients with intra-abdominal infections. In the subset of isolates from community-associated infections, susceptibility to levofloxacin decreased significantly, and the increasing rate of multi-drug-resistant E. coli approached statistical significance. In 2013, ertapenem, imipenem, and amikacin showed the highest susceptibility (≥99%), and fluoroquinolones the lowest (<70%). The ten ertapenem-non-susceptible isolates (0.3% of all E. coli) encoded one or more of carbapenemases, ESBLs, AmpCs, and non-ESBL β-lactamases. Copyright © 2015, American Society for Microbiology. All Rights Reserved.Antimicrobial Agents and Chemotherapy 03/2015; DOI:10.1128/AAC.05186-14 · 4.57 Impact Factor
Article: Dissemination of NDM metallo-β-lactamase genes among clinical isolates of Enterobacteriaceae collected from a global surveillance study: SMART 2008-2012.[Show abstract] [Hide abstract]
ABSTRACT: The prevalence of carbapenemase enzymes continues to increase. Among the Ambler class B enzymes is the New Delhi metallo-β-lactamase (NDM). This particular enzyme is capable of hydrolyzing nearly all β-lactam antimicrobial agents and has spread rapidly, becoming a global problem. Therapeutic treatment options for patients infected with isolates which produce this enzyme are difficult to manage as cross-resistance to other antimicrobial classes is common. The Study for Monitoring Antimicrobial Resistance Trends (SMART) is a global surveillance study evaluating antimicrobial susceptibility of numerous Gram-negative bacterial species recovered from intra-abdominal and urinary tract infections. Clinical and Laboratory Standards Institute methods and molecular analysis identified 134 isolates of Enterobacteriaceae (nine species) and one Acinetobacter sp. with blaNDM genes. These isolates were collected in nine countries, and >95% of the isolates possessed the NDM-1 variant. MIC90 values were >4mg/L and >8mg/L for ertapenem and imipenem, respectively. No tested β-lactam or β-lactamase-inhibitor combination had activity against these isolates. Resistance to amikacin (79.9%) and levofloxacin (82.8 %) was common. Nearly all isolates encoded additional enzymes including AmpC cephalosporinases and extended-spectrum β-lactamases (ESBLs). There is an urgent need for infection control and continued global monitoring of isolates which harbor this enzyme as evidenced by recent outbreaks. Copyright © 2014, American Society for Microbiology. All Rights Reserved.Antimicrobial Agents and Chemotherapy 11/2014; DOI:10.1128/AAC.03938-14 · 4.45 Impact Factor
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ABSTRACT: We characterized Escherichia coli ST131 isolates among 116 carbapenemase-producing strains. Of isolates from 16 countries collected during 2008-2013, 35% belonged to ST131 and were associated with blaKPC, H30 lineage, and virotype C. This study documents worldwide incidents of resistance to "last resort" antimicrobial drugs among a common pathogen in a successful sequence type.Emerging infectious diseases 11/2014; 20(11):1928-31. DOI:10.3201/eid2011.141388 · 7.33 Impact Factor
Conference Paper: In vitro Activity of Key Antimicrobial Agents Against Bacterial Isolates From Intra-abdominal (IAI) and Skin and Wound (SW) Infections: Europe 2004-2013[Show abstract] [Hide abstract]
ABSTRACT: Background: IAI and SW infections present major challenges for hospitalized patients. Monitoring the resistance profiles expressed by the causative organisms is important. Therefore, data from the Tigecycline European Surveillance Trial (TEST) program were analyzed for the resistance patterns observed throughout Europe. Methods: Isolates were collected and tested locally by broth microdilution according to appropriate CLSI guidelines. Results of this study were based on isolates tested from 26 European countries from 2004 2013. Results: Antimicrobial: Percent Susceptible: IAI/SWa Organism (n): IAI/SW TIG AK AMP CFT LEV MER PT VAN Acinetobacter spp 163/1546 na/na 66/70 na/na 28/35 50/58 53/70 45/55 na/na Enterobacter spp 615/2478 96/96 98/98 2/4 53/65 84/89 96/98 68/78 na/na E. coli 1122/1748 100/100 99/99 38/32 84/76 74/64 99/100 91/90 na/na ESBL 128/311 100/100 94/96 na/na na/na 25/22 98/99 74/73 na/na K. pneumoniae 485/1156 97/96 96/95 2/3 75/67 79/73 95/93 78/76 na/na ESBL 82/266 94/96 88/88 na/na 4/0 89/34 89/88 32/43 na/na P. aeruginosa 367/2439 na/na 93/93 na/na na/na 70/67 65/76 76/75 na/na S. marcescens 101/861 94/96 99/98 5/4 78/83 93/93 96/99 87/94 na/na E. faecalis 366/1067 100/100 na/na 98/99 na/na 74/8 na/na na/na 98/99 E. faecium 381/356 100/100 na/na 21/17 na/na 17/17 na/na na/na 91/90 S. aureus, MSSA 100/3250 100/100 na/na na/na na/na 95/92 na/na na/na 100/100 S. aureus, MRSA 42/1302 100/100 na/na na/na na/na 12/16 na/na na/na 100/100 S. agalactiae 27/955 100/100 100/100 100/100 100/100 100/98 100/100 na/na 100/100 A na = breakpoints not defined or non-applicable, TIG (tigecycline; FDA breakpoints), AK (amikacin), AMP (ampicillin), CFT (Ceftriaxone), MER (meropenem), LEV (levofloxacin) PT (piperacillin/tazobactam), VAN (vancomycin) Conclusion: Against Enterobacteriaceae, including ESBL-producers, TIG, AK and MER were the most active agents; against gram-positive cocci TIG resistance was not encountered. For Acinetobacter spp. all agents demonstrated poor activity; against P. aeruginosa AK and PT were the most active agents. Given the propensity of the bacteria associated with IAI and SW infections, continued monitoring of antimicrobial activity in Europe is warranted.IDWeek 2014 Meeting of the Infectious Diseases Society of America; 10/2014
Conference Paper: Activity of Tigecycline and Comparators Against Lower Respiratory Tract (LRT) Isolates of Enterobacteriaceae from North America and Europe: 2009-2013[Show abstract] [Hide abstract]
ABSTRACT: Background: Enterobacteriaceae play a significant role in LRT infections in at risk patients, especially in the healthcare associated environment. Treatment options are increasingly limited due to increased resistance to cephalosporins and other antimicrobials, thus warranting careful monitoring of resistance trends. The purpose of this study was to determine the in vitro activity of Tigecycline and other key antibiotics against LRT isolates of Enterobacteriaceae obtained from patients in North American and European hospitals. Methods: From 2009-2013 8,361 Enterobacteriaceae from LRT specimens were obtained from geographically distributed sites as part of the multi-year Tigecycline Evaluation Surveillance Trial (TEST). MICs were determined by the local laboratory using supplied microdilution panels and interpreted according to CLSI guidelines. Results: Percent Susceptible 2009 2010 2011 2012 2013 NAa EUa NA EU NA EU NA EU NA EU Drug n = 440 601 576 1472 537 1100 943 1683 390 619 Amikacin 98.0 97.5 97.9 97.4 98.3 95.8 98.3 98.5 98.7 99.0 Cefepime 92.7 91.4 93.6 90.0 92.0 86.9 93.4 88.5 90.8 90.6 Ceftriaxone 73.9 72.1 72.1 67.7 75.6 69.7 80.3 71.0 78.2 71.1 Levofloxacin 83.4 84.2 86.6 82.1 84.4 81.4 87.6 83.6 85.4 83.4 Meropenem 96.4 97.2 96.2 98.7 97.8 96.5 97.3 97.0 96.2 97.7 Pip-Tazob 83.4 80.4 85.2 78.9 83.6 79.3 86.2 83.1 88.2 85.0 Tigecycline 98.0 94.7 96.4 96.4 96.8 97.7 96.3 97.0 96.2 97.0 aNA: North America, EU: Europe; Pip-Tazo = piperacillin/tazobactam Conclusion: Tigecycline, amikacin and meropenem consistently demonstrated the highest % susceptibility (> 95%) against LRT isolates of Enterobacteriaceae regardless of study year or geographic region. Ceftriaxone was less active against European isolates than against North American isolates overall irrespective of study year possibly due to extended-spectrum β-lactamase prevalence in Europe vs. North America. Levofloxacin susceptibility was stable in the mid-80% range over all years. Tigecycline is not indicated for lower respiratory tract infections caused by Enterobacteriaceae.IDWeek 2014 Meeting of the Infectious Diseases Society of America; 10/2014
Conference Paper: Susceptibility trends for P. aeruginosa and A. baumannii from IAI in the USA: SMART 2009-2013[Show abstract] [Hide abstract]
ABSTRACT: Background: Because of their resistance to many antimicrobials, Pseudomonas aeruginosa and Acinetobacter baumannii remain pathogens of interest in intra-abdominal infections (IAI), representing approximately 10% and 3%, respectively, of aerobic gram-negative pathogens in IAI globally. This report from the Study for Monitoring Antimicrobial Resistance Trends (SMART) evaluates the susceptibility of P. aeruginosa and A. baumannii from IAI in the USA between 2009 and 2013. Methods: 27 US laboratories each collected up to 100 consecutive aerobic or facultative gram-negative isolates from IAI each year. Susceptibility was determined using the CLSI broth microdilution method and breakpoints. Linear trends in susceptibility were assessed with the Cochran-Armitage test. Results: Susceptibility trends and prevalence of 967 P. aeruginosa and 199 A. baumannii isolates are shown below. N and % of all gram-negative pathogens are listed in the legend. A sensitivity analysis was conducted for P. aeruginosa susceptibility using only the 12 sites that submitted isolates in all 5 years. The significant increasing trends for ceftazidime and piperacillin-tazobactam were confirmed, the trend for cefepime approached significance (p=0.08), and an additional significant increasing trend was found for levofloxacin (p=0.03). Conclusion: P. aeruginosa's prevalence was stable at around 12% of gram-negative pathogens isolated from IAI in the USA from 2009 to 2013. Its susceptibility to cefepime, ceftazidime and piperacillin-tazobactam showed statistically significant change (p<0.05), with these drugs demonstrating increasing susceptibility. A. baumanniis prevalence was lower and decreased significantly over the 5 years, but its susceptibility remained stable for all tested drugs between 2009 and 2013. Resistance does not appear to be increasing in these difficult-to-treat IAI pathogens.IDWeek 2014 Meeting of the Infectious Diseases Society of America; 10/2014
Conference Paper: Susceptibility of Enterobacteriaceae in European and North American Long-term Care Facilities, 2011-2013[Show abstract] [Hide abstract]
ABSTRACT: Background: Pathogens in some long-term care (LTC) facilities have been reported to have high antimicrobial resistance with a large proportion of multi-drug resistant (MDR) strains. Using data from the Tigecycline Evaluation and Surveillance Trial (TEST), Enterobacteriaceae from LTC settings were compared to other inpatient and outpatient settings in Europe and North America. Methods: 512 Enterobacteriaceae isolates from various specimen sources were collected from LTC facilities, and 27,569 Enterobacteriaceae from inpatient and outpatient settings in 15 countries in Europe and North America from 2011 to 2013. MICs were determined at each site using CLSI broth microdilution method and interpreted according to CLSI/FDA guidelines. Isolates were categorized as MDR if resistant to ≥3 drug classes. Results: MIC90 (mcg/ml), % susceptible (%S), and % MDR among Enterobacteriaceae from each setting are shown below. %S values ≥ 90% are shaded. Of the species with n >10, Enterobacter cloacae had the highest proportion of MDR strains in LTC and inpatient settings (41.4% and 39.8%, respectively), whereas Citrobacter freundii had the highest for outpatients (34.7%). Conclusion: A significantly higher proportion of Enterobacteriaceae were MDR in LTC settings than in inpatients and outpatients. All study drugs showed lower susceptibility in LTC isolates than in the other two settings. Amikacin, meropenem, and tigecycline were the only drugs studied that showed only minor differences in %S between the three settings. These three agents also demonstrated the highest in vitro activity against Enterobacteriaceae, with susceptibility >90% in all three settings. Empiric therapy decisions should take into account the high proportion of MDR isolates in LTC settings.IDWeek 2014 Meeting of the Infectious Diseases Society of America; 10/2014
Conference Paper: Epidemiology and Antimicrobial Susceptibility of Gram-Negative Pathogens Causing Intra-Abdominal Infections in Pediatric Patients in the U.S. SMART 2010-2013[Show abstract] [Hide abstract]
ABSTRACT: Background: Community-associated (CA) and hospital-associated (HA) intra-abdominal infections (IAI) are a major cause of morbidity and, if not properly treated, mortality. The Study for Monitoring Antimicrobial Resistance Trends (SMART) has tracked epidemiology and susceptibility of aerobic gram-negative pathogens (GNP) causing IAI since 2002; this report summarizes the findings for pediatric patients in the U.S. during 2010-2013. Methods: 23 U.S. hospitals each collected up to 100 non-selected, consecutive GNP per year, including 300 pediatric GNP in 2010-2013. Organisms were classified as either CA or HA if isolated <48h or ≥48h from admission. Susceptibility and ESBL phenotypes were determined using CLSI broth microdilution. Results: Shown below is the susceptibility of the top 4 species and of all GNP combined (using appropriate CLSI breakpoints and assuming 0% susceptible for species with no breakpoints for any given drug). Only selected agents are shown (one agent per major drug class tested). Analysis of extended-spectrum β-lactamase (ESBL) phenotypes showed 4%, 6%, and 4% of E. coli and 13%, 13%, and 0% of K. pneumoniae (albeit with small n's) to be ESBL-positive in all, HA, and CA IAI, respectively. Conclusion: Although the top 4 species found in HA and CA IAI were identical, the proportion of E. coli was significantly different: 41% in HA IAI vs. 55% in CA IAI. P. aeruginosa and E. cloacae tended to be more prevalent in HA IAI. Susceptibility was frequently lower in HA than CA. Of the agents tested, AMK had the highest in vitro activity vs. all GNP. ETP showed excellent activity vs. Enterobacteriaceae. Differences in species prevalence and susceptibility between HA and CA pediatric IAI indicate a need for different treatment options for these infections.IDWeek 2014 Meeting of the Infectious Diseases Society of America; 10/2014
Conference Paper: C-762 - Activity of Ceftaroline and Comparators against Respiratory Tract Pathogens Collected from Latin America: The AWARE Surveillance Program 2012-2013[Show abstract] [Hide abstract]
ABSTRACT: Background: Ceftaroline (CPT), the active metabolite of ceftaroline fosamil, is a cephalosporin with in vitro activity against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA), streptococci, and common Enterobacteriaceae (excluding strains producing serine β-lactamases). This report from AWARE, a global surveillance program, summarizes the in vitro activity of CPT and comparators against respiratory tract infection (RTI) pathogens collected in Latin America from 2012-13. Methods: RTI pathogens were collected from 17 medical centres in Argentina, Brazil, Chile, Colombia, Mexico, and Venezuela 2012-13. Sources included: sputum, endotracheal aspirate, bronchoalveolar lavage and bronchial brushings. MICs were determined by broth microdilution as specified by the CLSI and the results interpreted by CLSI breakpoints. Results: Susceptibility % for selected drugs and species are shown in the table below; values >=90% are shaded; na=no breakpoints, and "-" indicates not tested. Conclusions: Ceftaroline demonstrated excellent in vitro activity against S. pneumoniae with activity comparable to LVX, MXF and LZD. Activity against H. influenzae isolates was also excellent and comparable to AMX, CRO, and LVX. Ceftaroline activity against S. aureus was 79% (100% of MSSA isolates were susceptible). Ceftaroline activity against E. coli and K. pneumoniae was similar to AMX while ceftaroline had no activity against K. pneumoniae or E. coli producing serine β-lactamases (data not shown).54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC),, Washington, DC; 09/2014
Conference Paper: C-760 - In Vitro Activity of Ceftaroline against Contemporary Staphylococcus aureus Isolates (2013) from Latin American Countries: AWARE Surveillance Program[Show abstract] [Hide abstract]
ABSTRACT: C-760 In Vitro Activity of Ceftaroline against Contemporary Staphylococcus aureus Isolates (2013) from Latin American Countries: AWARE Surveillance Program D. Hoban1, M. Hackel1, R. Badal1, E. Reiszner2 and J. Ambler2 1IHMA Inc. Schaumburg, IL. USA 2AstraZeneca Pharmaceuticals, Waltham, MA, USA Background: Ceftaroline (CPT), the active metabolite of ceftaroline fosamil is the first cephalosporin with enhanced anti-staphylococcal activity (including methicillin-resistant S. aureus [MRSA]) indicated for the treatment of adults with complicated skin and soft tissue infections (cSSTI) and community-acquired pneumonia (CAP). This report from AWARE, a global CPT surveillance program, summarizes the in vitro activity of CPT against S. aureus isolates collected in Latin America (LA). Methods: Susceptibility testing of 1,182 S. aureus isolates (488 methicillin-susceptible S. aureus, 694 MRSA) collected in 2013 from 22 hospitals, in 6 LA countries (Argentina, Brazil, Chile, Colombia, Mexico, and Venezuela). Isolates were sourced from specimens from patients with SSTI (abscess, burn, carbuncle, cellulitis/erysipelas, decubitus, furuncle, impetiginous lesions, skin ulcer, wound) and lower respiratory tract infections (bronchial washing, bronchial alveolar lavage, endotracheal aspirate, sputum). Testing was performed by broth microdilution and MIC results were interpreted according to CLSI performance standards. Results: Of the 1,182 S. aureus tested 88.4% were CPT susceptible. All MSSA isolates were CPT susceptible (MIC range 0.06-0.5 mg/L, MIC90 0.25 mg/L). CPT activity against MRSA isolates is summarized in the table. Conclusions: All MSSA isolates were susceptible in vitro to CPT. Marked diversity in susceptibility across LA countries was observed in vitro with MRSA (%S ranged from 31.2% in Chile to 100% in Colombia). Across the LA region 80.3% of MRSA were reported as susceptible, 19.6% as intermediate and 0.1% (1 isolate) as resistant with an MIC of 4 mg/L.54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC),, Washington DC; 09/2014
Article: Antimicrobial susceptibility and extended-spectrum beta-lactamase rates in aerobic gram-negative bacteria causing intra-abdominal infections in Vietnam: report from the Study for Monitoring Antimicrobial Resistance Trends (SMART 2009–2011)[Show abstract] [Hide abstract]
ABSTRACT: Treatment options for multidrug-resistant pathogens remain problematic in many regions and individual countries, warranting ongoing surveillance and analysis. Limited antimicrobial susceptibility information is available for pathogens from Vietnam. This study determined the bacterial susceptibility of aerobic gram-negative pathogens of intra-abdominal infections (IAIs) among patients in Vietnam during 2009–2011. A total of 905 isolates were collected from four medical centers in this investigation as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). Antimicrobial susceptibility and extended-spectrum beta-lactamase (ESBL) rates among the appropriate species were determined by a central laboratory using Clinical and Laboratory Standards Institute (CLSI) methods. Among the species collected, Escherichia coli (48.1% ESBL-positive), and Klebsiella pneumoniae (39.5% ESBL-positive) represented the majority (46.4%) of the isolates submitted for this study. Ertapenem MIC90 values were lowest for these two species at 0.12 and 0.25 μg/ml, and remained unchanged for ESBL-positive isolates. Imipenem MIC90 values were also the same for all isolates and ESBL-positive strains at 0.25 and 0.5 μg/ml, respectively. Ertapenem MIC90 values for additional species with sufficient numbers for analysis, including Enterobacter cloacae, Proteus mirabilis, Acinetobacter baumannii, and Pseudomonas aeruginosa, were 1, 0.06, >4, and >4 μg/ml, respectively. Analysis of beta-lactamases in a subset of 132 phenotypically ESBL-positive Enterobacteriaceae demonstrated that CTX-M variants, particularly CTX-M-27 and −15, were the predominant enzymes. High resistance rates in Vietnam hospitals dictate continuous monitoring as antimicrobial inactivating enzymes continue to spread throughout Asia and globally.Diagnostic Microbiology and Infectious Disease 08/2014; DOI:10.1016/j.diagmicrobio.2014.05.009 · 2.57 Impact Factor
Article: Antimicrobial susceptibility of Gram-negative bacteria causing intra-abdominal infections in China: SMART China 2011.[Show abstract] [Hide abstract]
ABSTRACT: The Study for Monitoring Antimicrobial Resistance Trends program monitors the activity of antibiotics against aerobic and facultative Gram-negative bacilli (GNBs) from intra-abdominal infections (IAIs) in patients worldwide.
Conference Paper: Activity of ceftaroline and comparators against Streptococcus pneumoniae from multiple specimen sources in the European region 2012: assessing worldwide antimicrobial resistance evaluation (AWARE) programme[Show abstract] [Hide abstract]
ABSTRACT: Activity of ceftaroline and comparators against Streptococcus pneumoniae from multiple specimen sources in the European region 2012: assessing worldwide antimicrobial resistance evaluation (AWARE) programme Hoban D.; Badal R.; Biedenbach D.; Hackel M.; Bouchillon S.; Ambler J. Objectives: Streptococcus pneumoniae (SP) remains a significant pathogen isolated from many infectious processes. Increasing penicillin, macrolide and cephalosporin resistance in SP increases the need for new effective antimicrobials. Ceftaroline, the active metabolite of ceftaroline fosamil, is a cephalosporin with in vitro activity against Gram-positive pathogens and common Gram-negative pathogens. The in vitro activity of ceftaroline and comparators against SP including resistant strains isolated across the European region in 2012 from the AWARE programme are reported. Methods: 62 medical centers in 17 European countries (Austria, Belgium, Czech Republic, Denmark, France, Germany, Greece, Hungary, Italy, Portugal, Romania, Russia, Spain, Sweden, Netherlands, Turkey and United Kingdom) collected 815 SP isolates from multiple specimen sources. MICs were performed as specified by CLSI using prepared broth microdilution panels and interpreted according to EUCAST guidelines and breakpoints. Results: The in vitro activity of ceftaroline and 7 comparator agents are shown in the table. Drugs % Susceptible/MIC90 (mg/L) All SP PSSP PISP PRSP MRSP CROSP Isolate # 815 556 206 53 228 17 CPT 99.1/0.12 100/0.008 100/0.12 86.8/0.5 96.9/0.12 58.8/0.5 CRO 85.4/1 99.8/0.03 68.5/2 0/>4 59.7/2 0/>4 CLI 80.5/>1 93.0/0.06 59.7/>1 30.1/>1 35.1/>1 41.2/>1 ERY 71.4/>1 89.0/1 37.9/>1 17.0/>1 0/>1 11.8/>1 LVX 99.3/1 100/1 97.1/1 100/1 98.3/1 100/1 LZD 100/1 100/1 100/1 100/1 100/1 100/2 MXF 99.4/0.25 100/0.25 98.1/0.25 98.1/0.25 97.8/0.25 100/0.25 PEN 68.2/2 100/0.03 0/2 0/>8 25.0/4 0/>8 CPT ceftaroline, CRO ceftriaxone, CLI clindamycin, ERY erythromycin, LVX levofloxacin, LZD linezolid, MXF moxifloxacin, PEN penicillin ALL SP: All S. pneumoniae, PSSP: penicillin-susceptible SP (penicillin MIC<=0.06 mg/L), PISP: penicillin-intermediate SP (penicillin MIC=0.12-2 mg/L), PRSP: penicillin-resistant SP (penicillin MIC>2mg/L), MRSP: macrolide-resistant SP (erythromycin MIC >0.5mg/L), CROSP: ceftriaxone-resistant SP (ceftriaxone MIC>2mg/L). Conclusions: Ceftaroline demonstrated excellent in vitro activity against SP with percent susceptible =>99% for penicillin-susceptible and intermediate strains. Activity was reduced for penicillin- (86.8%) and ceftriaxone-resistant (58.8%) strains. Overall, the susceptibility of SP to ceftaroline was comparable to levofloxacin and moxifloxacin at their respective EUCAST breakpoints.24th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain; 05/2014
Article: In vitro susceptibility of Gram-negative isolates from patients with urinary tract infections in Vietnam: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)05/2014; DOI:10.1016/j.jgar.2014.04.003
Article: In vitro susceptibility and distribution of beta-lactamases in Enterobacteriaceae causing intra-abdominal infections in North America 2010-2011.[Show abstract] [Hide abstract]
ABSTRACT: The Study for Monitoring Antimicrobial Resistance Trends has been monitoring the activity of antimicrobials indicated for the treatment of intra-abdominal infections since 2004. This report documents the in vitro activity of several recommended antimicrobials against 3449 gram-negative bacilli isolated from the 30 and 25 participating sites in North America in 2010-2011, respectively, and characterizes the extended-spectrum beta-lactamases (ESBL) identified in ESBL-positive and ertapenem-non-susceptible isolates of Enterobacteriaceae. Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Klebsiella oxytoca, Citrobacter freundii, Enterobacter aerogenes, Serratia marcescens, and Morganella morgannii were the most common species isolated. The incidence of beta-lactamase production was 8.8% and 8.9% for E. coli and K. pneumoniae, respectively. Overall the most active antimicrobials were amikacin, piperacillin-tazobactam, imipenem, and ertapenem, although beta-lactamase production reduced the activity of most agents. Characterization of beta-lactamase genes determined that blaSHV, blaCTX-M, blaAmpC, and blaKPC were commonly found in most beta-lactamase-positive isolates.Diagnostic microbiology and infectious disease 04/2014; DOI:10.1016/j.diagmicrobio.2014.03.026 · 2.45 Impact Factor
Article: Epidemiology and antimicrobial susceptibility of Gram-negative aerobic bacteria causing intra-abdominal infections during 2010-2011.[Show abstract] [Hide abstract]
ABSTRACT: The study for monitoring antimicrobial resistance trends (SMART) surveillance program monitors the epidemiology and trends in antibiotic resistance of intra-abdominal pathogens to currently used therapies. The current report describes such trends during 2010-2011. A total of 25 746 Gram-negative clinical isolates from intra-abdominal infections were collected and classified as hospital-associated (HA) if the hospital length of stay (LOS) at the time of specimen collection was ≧48 hours, community-associated (CA) if LOS at the time of specimen collection was <48 hours, or unknown (no designation given by participating centre). A total of 92 different species were collected of which the most common was Escherichia coli: 39% of all isolates in North America to 55% in Africa. Klebsiella pneumoniae was the second most common pathogen: 11% of all isolates from Europe to 19% of all isolates from Asia. Isolates were from multiple intra-abdominal sources of which 32% were peritoneal fluid, 20% were intra-abdominal abscesses, and 16·5% were gall bladder infections. Isolates were further classified as HA (55% of all isolates), CA (39% of all isolates), or unknown (6% of all isolates). The most active antibiotics tested were imipenem, ertapenem, amikacin, and piperacillin-tazobactam. Resistance rates to all other antibiotics tested were high. Considering the current data set and high-level resistance of intra-abdominal pathogens to various antibiotics, further monitoring of the epidemiology of intra-abdominal infections and their susceptibility to antibiotics through SMART is warranted.Journal of chemotherapy (Florence, Italy) 02/2014; DOI:10.1179/1973947814Y.0000000164 · 0.83 Impact Factor
Article: Evaluation of The Clinical and Laboratory Standards Institute (CLSI) Phenotypic Confirmatory Test to Detect the Presence of Extended-Spectrum Beta-lactamases (ESBL) from 4,005 Escherichia coli, Klebsiella oxytoca, Klebsiella pneumonia and Proteus mirabilis.[Show abstract] [Hide abstract]
ABSTRACT: A sub-set of Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae and Proteus mirabilis collected for the Study for Monitoring Antimicrobial Resistance Trends (SMART) that were positive for the CLSI extended-spectrum beta-lactamase (ESBL) phenotypic confirmatory test (N=3,245) or had an ertapenem MIC of ≥0.5μg/ml (N=293) or both (N=467) were analyzed for ESBL genes. Most ESBL phenotype E. coli or K. pneumoniae possessed an ESBL gene (95.8% & 88.4%, respectively) or 93.1% if carbapenem non-susceptible K. pneumoniae were removed. This rate was lower for P. mirabilis (73.4%) and K. oxytoca (62.5%). Virtually all ESBL-positive isolates (99.5%) were cefotaxime non-susceptible (CLSI or EUCAST breakpoints). Fewer (82%) were ceftazidime non-susceptible (CLSI breakpoints). Also 21.1% of E. coli, 25% of K. oxytoca and 78.7% of P. mirabilis were ceftazidime-susceptible but ESBL-positive. This suggests CLSI breakpoints for ceftazidime are too high to detect ESBLs. The lower EUCAST breakpoints detected ESBLs in E. coli and K. oxytoca better, but 59.6% of ESBL-positive isolates of P. mirabilis were ceftazidime-susceptible. For isolates with ertapenem MIC ≥ 0.5μg/ml, more accurate ESBL phenotype analysis was observed for E. coli and K. pneumoniae (sensitivity >95% for both, specificity 94.4% and 54.1%, respectively). If carbapenemase-positive K. pneumoniae were excluded specificity increased to 78%. The positive predictive values for the ESBL phenotypic test with E. coli and K. pneumoniae were 97.6% and 81.8%, respectively and negative predictive values were 75.9% and 95.2%, respectively. We therefore suggest it would be prudent to confirm phenotypic ESBL-positive P. mirabilis, K. pneumoniae and K. oxytoca with molecular analysis.Journal of Medical Microbiology 01/2014; 63. DOI:10.1099/jmm.0.068981-0 · 2.27 Impact Factor
Article: A Review of Ten Years of the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2002 to 2011.[Show abstract] [Hide abstract]
ABSTRACT: Surveillance of antimicrobial agent resistance provides important information to guide microbiologists and infectious disease specialists understanding of the control and the spread of resistance mechanisms within the local environment. Continued monitoring of antimicrobial resistance patterns in the community and in local hospital environments is essential to guide effective empiric therapy. The Study for Monitoring Antimicrobial Resistance Trends (SMART) has monitored the in vitro susceptibility patterns of clinical Gram-negative bacilli to antimicrobial agents collected worldwide from intra-abdominal infections since 2002 and urinary tract infections since 2009. Resistance trends, with a particular focus on carbapenem resistance and the rate of extended-spectrum β-lactamases (ESBLs), were analyzed. Isolates from intra-abdominal infections (n = 92,086) and urinary-tract infections (n = 24,705) were collected and tested using Clinical and Laboratory Standards Institute methods. This review presents carbapenem susceptibility and ESBL rates over ten years of SMART study analysis, including key publications during this period. The SMART study has proved to be a valuable resource in determining pathogen prevalence and antibiotic susceptibility over the last ten years and continues to provide evidence for regulatory susceptibility breakpoints and clinical decision making.Pharmaceuticals 11/2013; 6(11):1335-1346. DOI:10.3390/ph6111335
Conference Paper: In Vitro Activity of Ertapenem and Comparators against Aerobic Gram-negative Intra-Abdominal Infection (IAI) Pathogens in the USASMART 2012[Show abstract] [Hide abstract]
ABSTRACT: Background: The IDSA and the SIS updated guidelines for IAI therapy in 2010. The Study for Monitoring Antimicrobial Resistance Trends (SMART) is a longitudinal surveillance study that has tracked the in vitro activity of drugs commonly used to treat IAI since 2002. This report summarizes in vitro activity of amikacin (AK), ampicillin-sulbactam (AS), cefepime (CPE), cefotaxime (CFT), cefoxitin (CFX), ceftazidime (CAZ), ceftriaxone (CAX), ciprofloxacin (CP), ertapenem (ETP), imipenem (IMP), levofloxacin (LVX), and piperacillin-tazobactam (PT), against aerobic gram-negative bacilli (GNB) isolated in 2012 from IAI in the US. Methods: 12 laboratories in the US each collected up to 100 consecutive isolates of GNB from IAI in 2012 for a total of 991 isolates. Isolates were sent to a central laboratory for confirmation of identification; ESBL status and broth microdilution susceptibility were determined using CLSI broth microdilution. IAI was defined as hospital-associated (HA) or community-associated (CA) if cultured ≥48 hours or <48 hours post admission, respectively. Statistical significance was determined using Fisher's exact test. Results: The 2 most prevalent species, E. coli and K. pneumoniae, accounted for 55% of all isolates, and had ESBL rates in HA/CA of 8%/7% and 15%/7%, respectively. 97% of 794 Enterobacteriaceae were ETP susceptible (S). Susceptibility (with 95% confidence limits) of all isolates combined, using breakpoints appropriate for each species (0% S assumed for species with no breakpoints for any given drug) is summarized by HA and CA, below; asterisks by drug names indicate a significant difference (p<0.05) between HA and CA values. s Conclusion: ESBL rates in IAI in the US are relatively unchanged from earlier SMART reports, and remain much lower than reported in most countries, leading to higher levels of susceptibility to cephalosporins and fluoroquinolones than typically seen internationally. All study drugs except AK and IMP had significantly lower %S in HA than in CA. AK (97.8%) and ETP (97.2%) were the most active vs. Enterobacteriaceae, while AK (86.2%) and CAZ (78.7%) were the most active vs. non-Enterobacteriaceae. SMART data can be useful to help guide evolving IAI treatment guidelines to reflect resistance trends.IDWeek 2013 Meeting of the Infectious Diseases Society of America; 10/2013
Conference Paper: Epidemiology of ESBL-Producers in Intra-Abdominal Infections in Adults in ICU versus non-ICU wards in North America: SMART 2010-2012[Show abstract] [Hide abstract]
ABSTRACT: Background: ICU admission has been identified as a risk factor for extended-spectrum β-lactamase (ESBL) infections, especially in Klebsiella .This report from the Study for Monitoring Antimicrobial Resistance Trends (SMART) summarizes the occurrence of ESBL producers in IAI in 2010-2012 in North America (NA), comparing ICU and non-ICU wards. Methods: 29 sites in the US and Canada collected up to 100 consecutively isolated gram-negative pathogens (GNP) from adults with IAI per year. Susceptibility and ESBL phenotypes were determined by microdilution per CLSI and plate manufacturer guidelines for 4,249 GNP. An IAI was defined as hospital-associated (HA) or community-associated (CA) if cultured ≥48 hours or <48 hours post admission, respectively. ESBL rates were compared with the Fisher exact test. Results: Escherichia coli, K. pneumoniae, Proteus mirabilis, and K. oxytocacomprised 64% of all IAI GNP. Prevalence rates of each species and ESBL rates are shown below: ICU wards Non-ICU wards HA CA Total HA CA Total All organisms n 471 343 814 1640 1795 3435 E. coli n 167 136 303 623 743 1366 Prevalence (%) 35.5 39.7 37.2 38.0 41.4 39.8 ESBL+ rate (%) 12.0* 2.9* 7.9 10.9 7.4 9.0 K. pneumoniae n 77 66 143 271 331 602 Prevalence (%) 16.3 19.2 17.6 16.5 18.4 17.5 ESBL+ rate (%) 11.7 9.1 10.5 11.1 7.3 9.0 P. mirabilis n 15 14 29 44 86 130 Prevalence (%) 3.2 4.1 3.6 2.7 4.8 3.8 ESBL+ rate (%) 0 0 0 6.8 1.2 3.1 K. oxytoca n 11 15 26 61 77 138 Prevalence (%) 2.3 4.4 3.2 3.7 4.3 4.0 ESBL+ rate (%) 9.1 6.7 7.7 4.9 5.2 5.1 * HA and CA significantly different (p<0.05). Note: Differences between ICU and non-ICU wards not significant (p>0.05). Conclusion: * While higher ESBL rates in ICU than non-ICU wards have been reported elsewhere, our results for IAI GNP showed no significant differences in NA. * Clearer differences are seen between HA and CA infections, with ESBL rates tending to be higher in HA IAI in both ICU and non-ICU settings (but only statistically significant for E. coli in ICUs). * These results concur with a 2004 CDC National Nosocomial Infections Surveillance report with similar rates of K. pneumoniae and E. coli resistant to 3rd gen. cephalosporins in US ICU and non-ICU wards. Although ICU admission has been reported to be a risk factor for ESBL infection, our data suggest that may not be the case in NA.IDWeek 2013 Meeting of the Infectious Diseases Society of America; 10/2013
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Oxford University Clinical Research UnitThành phố Hồ Chí Minh, Ho Chi Minh City, Vietnam
National Institute of Animal HealthEdo, Tōkyō, Japan


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The Mighty Avenger. Volume 1
From Library Staff
I've honestly never been much of a Thor fan, but with a new movie coming out there has been a resurgence of interest in the Odinson. This book was receiving rave reviews online, and now I'm so glad I checked it out! The story takes a "monster of the week" approach while still building a... Read More »
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Finish could have been a little better,but they look pretty good
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theyre cool for the money
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They look real nice on my custom trike.
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Very nice mirrors.
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14 New Year's Eve Party Ideas, Recipes, Drinks & Decorations
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Stunning New Year's Centerpiece
By: Dondi Richardson for Flora Craft
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A blue and silver tablescape is great for New Year's eve celebrations. With this Stunning New Year's Centerpiece from FloraCraft, you're guests are sure to be impressed. Use STYROFOAM of various heights and sizes to create something elegant and striking.
- STYROFOAM™ Brand Foam Balls: 2", 2.5", 3"
- Mini Silver Ornaments
- Ribbons: 1.5" wide blue/brown, and 7/8" wide blue shimmer
- Glass or Acrylic Gems: Icy Blue
- Low-Temp Glue Gun & glue sticks
- Silver Ornament Ball: Remove hangers from mini silver ornaments. Attach the tops of the ornaments into the ball of STYROFOAM* using low-temp glue until the ball is completely covered. (Hint: it takes about 36 – ¾" mini ornaments to cover a 2.5" ball.)
- Ribbon Wrapped Ball: Glue one end of the blue/brown ribbon to the side of a ball and wrap all the way around gluing again where you started. Repeat this step with lengths of ribbon to completely cover the ball. Glue the blue shimmer ribbon on top of the blue/brown ribbon wrapping the ball twice dividing it into quarters as shown.
- Blue Gem Ball: Attach the gems using low-temp glue to completely cover the ball and press the gems on tightly. Press gems for a few seconds, giving the glue time to dry.
- Arrange on a platter or directly on the table. Decorate STYROFOAM cones for added dimension.
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NewsMay 09 2012
Spruce added to Kennebec School yard
Posted by Lucy
In honor of Arbor Day, April 27 and the Lions International Tree Planting Year, the Medicine Creek Lions Club of Prehso donated a Black Hills Spruce tree to both Lyman School sites. Club member Angela Ehlers, with assistance from the Kennebec's first grade class and teacher Mrs. Natasha Thiry planted the tree Thursday, May 3 between the gym and the school. The students all received a honey locust tree to take home and plant.
- Inured Highway Patrol Trooper returns to work
- No April Fool's Joke
- Successfull Shamrock Shuffle
- Speed limit and fees increase April 1
- Wheat Growers holds open house in Kennebec
- Central South Dakota 's Scavengers Journey set for June
- Coach receives star quilt
- Irish celebration draws near
- Annual event draws crowd to Presho gym
- Presho, Kennebec to hold city elections
- Wheat Growers releases site layout for new facility at Kennebec
- Lyman meets Jones Co. in Dist. 13B Championship game on Thursday


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Oh I remember, it took me so much time to actually know I was wrong.
I thought that Special Attack meant moves that are super effective against and Special Defense was your defense for super effective moves.
Oh I remember, it took me so much time to actually know I was wrong.
I thought that Special Attack meant moves that are super effective against and Special Defense was your defense for super effective moves.
« New beginnings are often disguised as painful endings. » *
I will be completely absent from March 22nd to April 5th.
When I was a kid I used to play Gold on an emulator - I didn't have a GBC and there was a guide in some magazine I used to buy back in the day so dad set it up for me. Anyway, whenever I picked my starter I didn't realize you're being asked to nickname it, so I would try to remember the Pokemon's name and then enter it in the nickname field. I didn't know about gyms so I would just run around until I found the Sudowoodo and I had no idea how to get past it, so I would restart the game and play it over and over again. Plus, I'm pretty sure I didn't know you could save the game anyway.
... All this can be explained with the fact that I didn't speak English back then.
I thought that Gyarados was all powerful before Gen IV. I didn't realise that its Sp. ATK was horrible and all of its STAB moves were kinda weak.
The red and blue rumor that you could use strength on the truck near the S.S. Anne and get mew.
Omega Sapphire team
Y Team
I thougt water was super effective on fighting, because Machop appeared in caves, like Geodude.
Pardon my grammar, I'm a young Dutchman.
I used a master ball on caterpie.
I used to teach my pokemon moves of their own type only.
String Shot + Silver Wind + Aerial Ace + Gust on
Surf + Dive + Waterfall + Muddy Water on
Last edited by Silicone; 30th April 2013 at 9:15 AM.
I also thought that Grass is weak to Psychic. Guess I just got used to Grass/Poison Pokémon.
Before I knew anything about what Pokemon actually was, I saw an ad in some magazine (prob Nintendo Power) and I thought Pikachu evolved into Snorlax (similar ears) and that Snorlax's name was "Pokemon" and it was the most powerful.
John 3:16 - For God so loved the world that He gave His one and only Son that whoever believes in Him should not perish but have eternal life
My mane pokeymanz in xfacebook.com/geeksforjesus2ds friend code - 4613 7899 0504
Looking for: purified shadow pokemon, pokemon in hg/ss exclusive pokeballs, y exclusive mega stones
I remember my "melting theory." I noticed very early on that, despite still being "not very effective," Fire-type attacks would do a lot more damage to Rock Pokemon than Normal or Flying attacks would. I developed a theory that my Fire Pokemon were, in fact, melting down the Rock Pokemon into a molten liquid state. I couldn't think of any other reason for this phenomenon!
Spoiler:- My Blog and Friend Codes:
My Shinies:
Rayze Darr's Game Reviews. WARNING: ADULT LANGUAGE. Any and all feedback appreciated!
3DS Friend Code: 5327 - 0902 - 3469 New Leaf Dream Address: 5500 - 2146 - 0428
Everyone together! · 大家聚合!· Alles zusammen! · 모두 함께! · 一緒にみんな!
Source: Bulbapedia
White 2 - Drake - 2838 9377 20073DS - 0232-7984-8655Shinies:
DWFs: PM for details.
Open GMT 1100-1600 on weekdays & GMT 0000-1600 on weekends.
Important info may be given through voice chat during trades.
Si vis pacem, para bellum
I don't know if it's really all that ridiculous of an assumption, but I used to think Banette's zippered mouth was a row of yellow teeth with one really long tooth on one end.
LOOKING FOR A SHINY ONIX/STEELIX and SHINY SCYTHER/SCIZOR and SHINY SLOWPOKE . I HAVE POKEBANK CELEBI FOR TRADE AND SOME OTHER SHINIES. PM IF INTERESTED.
i will say that because of the tcg i thought that electric types were weak to fighting types. i didn't realise it wasn't until my friend pointed it out.
Always watching. Always waiting. Never truly at peace in a realm of its own.
Giratina will return....someday.
Credit to Astral Shadow of the Under
I released my Nidoking in Pokemon Yellow because I didn't know what the word meant at the time.
My shiny Pokemon:
111 eggs (Also my 649th Pokemon) 194 eggs
I love this idea, Nintendo should do this ASAP!Originally Posted by Azimuth1011
As a kid I thought many things. I dont now. One thing, I thought faintged pokemon who are not one of mine DIED. (UNTIL I saw the anime) I also thought that ALL pokemon were genderless. (again the anime cleared this up for me) I thought also that maybe Pokemon were created by humans in a lab (no idea why I thought this XD)
When I first played Emerald when I was little, I had no idea what the PC was. When I first opened the Pokemon Storage System, I thought it was a minigame or something. I thought you could only ever have 6 pokemon at a time.
Platinum FC: 3438 9213 7612
White FC: 5372 3970 3594
Black2 FC: 2280 4478 7008
Xbox Live Gamertag: Homsar135
I was playing Platinum tonight, and remembered something so stupid that it made me facepalm: I thought that Pokerus was a bad thing. Even funnier was the fact that I knew what it was, but as soon as I learned that me Sudowoodo on Crystal had it, I forgot what it was, panicked, shoved it in the PC box and deleted my game. I regret it even now.
At least now my reaction is just "Whoa, what? My <generic Pokémon here> has Pokerus? Cool!"
This is Bidoof. Many people loathe it with their lives. If you are of the few people who love this little beaver, put this in your sig. Started by Earth Wolf-Howl (formerly Warrior Scolipede)
Friend Safari: Sunkern, Sawsbuck, Maractus
I have claimed Pyroar!
I thought rattata's last evolution was rhydon
I used to think Mewtwo evolved into Mew. XD
No one hears muffled screams. No one sees faded tears.
Like some people in this thread, I once believed a lowering stat move was permanent. xP
I thought Bidoof was a dog. At the time, my Poke's nicknames were what I thought they were (hence my Bronzor being called 'Thing'). When it evolved, Bidoof's line turned out to be beavers. So I had a beaver called 'dog' -.-
Also, I somehow thought Mewtwo was supposed to have Wonder Guard. When I discovered Pokésav, I hacked a Mewtwo with Wonder Guard, and ever since I create overlord teams, my Mewtwo gets Wonder Guard...
Last edited by appelpower; 3rd May 2013 at 11:23 PM.
Wild Future ~ Tyrone Walpole
I have claimed the Almighty Charizard.
I first thought PC meant Personal Computer.


text:
iittala Vitriini 2.3" Lemon Box
iittala Vitriini 2.3" Lemon Box
Weights & Dimensions
|Product Type: Accessory box
|Shape: Square
|Style: Contemporary
|Finish: Gold
|Life Stage: Adult
|Interior Material: Glass
|Exterior Material: Glass
|Interior Storage Included: No
|Drawers Included: No
|Mirror Included: No
|Doors Included: No
|Musical: No
|Personalizable: Yes
|Charging Station: No
|Figurine Included: No
|Locking: No
|Watch Winder: No
|Country of Manufacture: Finland
Still have questions about this product? We're here to help
iittala Vitriini 2.3" Lemon Box
About the Designer
Anu Penttinen
Anu Penttinen knows her glass, as it is her medium of choice as an artist and she has a studio at the Nuutajärvi Glass Village. She is a graduate of the University of Art and Design Helsinki, and her art reflects her interest in the phenomena and details of the urban environment. Maps, city streets, and transport – moving from place to place and location to location – have always fascinated her: "I filter out my visual world from concrete places and human activity, which can end up as abstracts for my glass pieces." Her preference is for strong colors and clarity of form.
About the ManufacturerIn the quiet north, there is a country that specializes in aesthetics and functional design. In Finland, in a town called Iittala, style and high quality are traditions that remain relevant for generations to come. Whenever an object is produced in the iittala factory, it has to feel, last and work like iittala. The tactility and high quality of the materials can be felt with your bare hands. Objects like that, will work anytime, anywhere with anything. Objects like that will never be thrown away.
NOTE: This product is subject to a minimum order quantity of 4
Tell us what you think!
Tell us what you think about this product. It will help us provide you with better products in the future and help your fellow shoppers make better purchases.Write the first review
OUR SKU # IIT2735Vitriini 2.3" Lemon Box is also sometimes listed under the following manufacturer numbers: VIT006253


text:
Oops, sorry if I missed that
Right, I attend a synagogue where Jesus is recognized as the Messiah. Those who don't believe are welcome to attend, of course.
And as for the large number of Jews who consider me not a Jew for my belief in Jesus as Messiah, I don't have an answer for them. You're right that they may find what I believe to be offensive, or they might try to disassociate themselves from me for my beliefs, but I can't stop believing something that I know is true.
It's clearly a divisive issue among Jews, but it doesn't have to be. I try my best to be respectful and truthful, and on a couple of occasions I've met Jews who have changed their minds and become Christian Jews.
I appreciate your concern, and I hope I didn't offend anyone here. It's certainly been a problem for me (and for the rest of our congregation) in the past. People have thrown bricks through windows, carved letters off of the building, spray painted, sent threats, and even pushed and hit members of our congregation. It's never dissuaded us from congregating and doing what we believe is right.
Michael Nystrom's fists can punch through FUD.


text:
"'Gangnam Style' Arrives at Penn"
13 Oct, 2012 by Craig Newmark
Print this article Font size -16+
Glad to see Penn students are: keeping busy.
Trending Today
Also see...
An Employee Of Golden Corral Got Terminated After He Went Public And Exposed This DISGUSTING Reality [Video]Feb 25, 2015 | By Terresa Monroe-Hamilton
It took a lot of guts to do what this young man did. They also offered him 20k in hush money. Fabulous. The proof in my opinion here is that...Read More
Lawmaker introduces bill to make yoga pants illegal; could be sentenced up to 'life in jail and a $10,000 fine'By Jennifer LawrenceMother of Murdered Seven-Year-Old Girl Gets Serious Closure: She Burned the Killer's House DownBy Cassy FianoWatch an Idiot Pick a Fight With a Retired Boxer Named 'Champ'By Rachel AlexanderA devastated father takes to Facebook with a blunt message after his son dies of an overdoseBy Rachel Alexander
Craig Newmark
Associate Professor of Economics, North Carolina State Univ.
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Music to Karmaloop founder's ears? Kanye West may be a buyer
The online apparel retailer's filing for Chapter 11 bankruptcy protection has drawn several potential suitors, including rapper West and music executive Damon Dash, Karmaloop ...
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The online retailer has spent nearly $300 million acquiring three shipping software vendors over the past nine months.
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The forces are gathering that could make for a serious debate next year about charging sales tax on web purchases.
I don't think Congress is going to pass an online sales tax bill this year. For one thing, there are many other pressing issues for lawmakers to take up in the few months left before they effectively call it quits in early October to run for reelection. For another, I don't see many House members wanting to go before the voters having just supported an extension of sales tax to online purchases.
But that doesn't mean yesterday's introduction of the so-called Main Street Fairness Act can be brushed aside by online retailers. My estimation is that the political forces are coming together to bring this question to a head in Congress, where it belongs (as opposed to being taken up one by one by the states, as we've seen happen in the past year.)
Retail chains have long lobbied for all online purchases to be subject to sales tax, because the big chains have stores in just about every state and thus have to collect sales tax on items they sell from their web sites. (The Supreme Court has ruled that only retailers with a physical presence in a state, such as a store or warehouse, can be required to collect and remit sales taxes.) Since the chains have to charge consumers sales tax, they know they are at a disadvantage in competing with web-only retailers that don't charge tax.
But now the retail chains have been joined by state governments that are billions short of balancing their budgets as a result of the recession-induced plunge in tax revenue of all kinds. The Obama administration can't be happy with all the layoffs in state government and service cutbacks. Just as one example, Detroit recently closed 77 parks to save money. That doesn't sound like the kind of hope millions of Americans were looking for when they voted for Obama.
I'm betting there will be a serious debate in Congress over passing an online sales tax bill in 2011, after the midterm elections and more than a year before the next presidential election. Meanwhile, here at Internet Retailer we're trying to figure out whether adding sales tax to an online purchase makes much difference in whether consumers buy. We'll be digging into real data, and reporting on what we find in an article by Paul Demery in the August issue of Internet Retailer magazine.
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Latest Photonics Stories
WASHINGTON, Nov.
The 50th anniversary celebration of the Abdus Salam International Centre for Theoretical Physics in Trieste, Italy, last month was a celebration of international scientific collaboration in promoting
New Market Research Reports Title Global Laser Processing Market Analysis Size And Segment Forecasts To 2020 Has Beed Added to GrandViewReseach.com Report Database.
Accelerates Development of Commercially Viable Bleached Waveguide Modulators to Address $300MM/Yr Market Opportunity LONGMONT, Colo., Oct.
CHATSWORTH, Calif., Oct. 29, 2014 /PRNewswire/ -- MRV Communications(TM), Inc.
Lasers – devices that deliver beams of highly organized light – are so deeply integrated into modern technology that their basic operations would seem well understood.
Former CEO of Life Technologies Corporation joins board of advanced photonics medical device company SAN FRANCISCO, Oct.
The Victorian Cosmetic Institute, experts in cosmetic surgery, presents a brand new video about the crowning achievement of cosmetic evolution: the "ray of light" or laser treatment. Dr.
BioSkin Laser, a leading brand in the area of medical aesthetics, announces a complete range of advanced treatments for the discerning woman of today. New York,
SINGAPORE, Oct. 22, 2014 /PRNewswire/ - Zecotek Photonics Inc.
Latest Photonics Reference Libraries
Nature Photonics is a peer-reviewed scientific journal established in 2007 and published monthly by the Nature Publishing Group. As with other Nature journals, this periodical has no external Editorial Board with editorial decisions made by a fully-functioning in-house team. The journal covers research related to optoelectronics, laser science, imaging, communications, and other aspects of photonics. It publishes review articles, research papers, news and commentary, and research...
- The practice of two or more parties jointly purchasing all or part of a butchered cow and dividing the meat between them.


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Bruckheimer Producing Sinister Director's Beware the Night
Jerry Bruckheimer Films will producer Beware the Night, a paranormal police thriller to be directed by Sinister's Scott Derrickson. Eric Bana in talks to star.
Jerry Bruckheimer Films will producer Beware the Night, a paranormal police thriller to be directed by Sinister's Scott Derrickson. Eric Bana in talks to star.
Paramount Pictures grapples with the release of the 3D-converted Top Gun and the planned sequel to the 1986 hit in the wake of Tony Scott's suicide.
Disney has premiered the teaser trailer for director Gore Verbinski's The Lone Ranger, the big-budget Western in which the story of the legendary masked hero is told from the perspective of the Native American spirit warrior Tonto.
Ahead of Wednesday's trailer premiere, Disney has released a teaser poster and three more photos for The Lone Ranger, director Gore Verbinski's big-budget Western that stars Johnny Depp and Armie Hammer.
Disney has released seven new images from The Lone Ranger, the big-budget Western that reunites Johnny Depp with Pirates of the Caribbean director Gore Verbinski and producer Jerry Bruckheimer.
Director Gore Verbinski reportedly has been asked to trim more scenes from Disney's The Lone Ranger as the budget for the Western creeps back up to its original $250 million.
Disney's CinemaCon 2012 presentation featured lots of new footage and announcements, including details on Iron Man 3, Oz the Great and Powerful, Frankenweenie, The Muppets 2 and The Lone Ranger.
Marvel has released six new behind-the-scenes photos from The Avengers featuring director Joss Whedon and stars Robert Downey Jr., Chris Hemsworth, Mark Ruffalo, Samuel L. Jackson and Jeremy Renner.
Producer Jerry Bruckheimer has released the first shot of Johnny Depp and Armie Hammer in Disney's big-budget Western The Lone Ranger.
The Town screenwriter Peter Craig is on deck to write the sequel to the 1986 Tom Cruise action drama Top Gun.
W. Earl Brown, Matt O'Leary, Leon Rippy and Harry Treadaway have landed roles in Disney's The Lone Ranger, joining Johnny Depp, Armie Hammer and others in the Gore Verbinski-directed Western.
Disney and Jerry Bruckheimer Films have announced the start of principal photography for The Lone Ranger, confirming the central cast and releasing an official synopsis for the big-budget Western.


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All Seasons Apparel, Inc.
B-401805,B-401805.2: Nov 4, 2009
Additional Materials:
- Full Report:
Ralph O. White
(202) 512-8278
(202) 512-4800
(202) 512-8278
Office of Public Affairs
(202) 512-4800
All Seasons Apparel, Inc. (ASA), of Post Falls, Indiana, a Historically Underutilized Business Zone (HUBZone) certified small business concern, protests the cancellation of request for proposals (RFP) No. W911QY-09-R-0024, issued as a HUBZone small business set-aside, by the U.S. Army Research, Development and Engineering Command, Natick Contracting Division, for Army combat shirts.
We deny the protest.
Mar 25, 2015
- Affolter Contracting Company, Inc.B-410878,B-410878.2
Mar 24, 2015
- Booz Allen Hamilton, Inc.; Leidos Inc.B-410032.4,B-410032.5,B-410032.6
- Visual Connections, LLCB-410777,B-410777.2
Mar 23, 2015
- AeroSage LLCB-410648.2,B-410648.3
- Sigmatech, Inc.B-410933
Mar 20, 2015
- ExecuTech Strategic Consulting, LLC; TRI-COR Industries, Inc.B-410893,B-410893.2,B-410893.3
- Smith and Nephew, Inc.B-410453
Mar 19, 2015
- Hanel Storage Systems, L.P.B-409030.2
Looking for more? Browse all our products here


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Illinois Public Media News
In-depth reporting from WILL, NPR, the Associated Press, and other sources
Contact WILL News at email@example.com
February 18, 2013
(Daniel M.N. Turner/NPR)
February 18, 2013
Protesters Call On Obama to Reject Keystone XL Pipeline
(Dan Charles/NPR)
February 18, 2013
Farmer's Fight With Monsanto Reaches The Supreme Court
(Jeff Bossert/WILL)
February 18, 2013
Public Safety, Development Issues Dominate Mayoral Debate
(J. Scott Applewhite/AP)
February 17, 2013
'Time And Casualties': Gen. Dempsey On Cost Of Sequester
Page 470 of 894 pages ‹ First < 468 469 470 471 472 > Last ›
WILL Newscast audio
NPR News
Still Need A Lawn Yeti? Good News — SkyMall May Be Cleared For Relaunch
The Sen. Menendez Indictment In Five Excerpts
Justice Department Won't Charge IRS' Lois Lerner With Criminal Contempt
Sen. Robert Menendez Indicted On Corruption Charges
California Governor Issues 1st-Ever Statewide Mandatory Water Restrictions
Iraq Claims Victory Over Militants In Strategic City Of Tikrit
Madison, Wis., Council Votes To Ban Discrimination Against Atheism
11 Former Atlanta Public School Employees Found Guilty In Cheating Scandal
U.S. Creates First Sanctions Program Against Cybercriminals
'Girl Drifter' Race Driver Freaks Out Instructors In Prank
More NPR News
WILL Highlights
The hidden racism of young white Americans
From PBS NewsHour: Look at data that shows the percentage of whites in each age group espousing racist ideas.
WILL-AM and reporting partners win AP Awards
A series by Illinois Public Media reporting partners won an AP award for Best Investigative Report. Former IPM reporter Sean Powers was named Best Reporter.
More than 100 people became new Friends of WILL during February. We're excited to have them as supporters!


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Taking notes with Jarnal
Jarnal provides some handy features that make this application more than just a note-taking tool.
Text editors and word processors are good for writing and editing text, but they are not up to snuff when it comes to taking notes, annotating documents, and doodling. For this purpose, you need a dedicated tool like Jarnal, a unique application that can make your computing more efficient.
Although Jarnal is a perfect companion for Tablet PCs, you can easily use it on your regular laptop and even on a desktop system. However, if you plan to use Jarnal for some serious work, you should consider investing in a pen tablet if you don't already have one. Pen tablets are cheap, and you can pick up a new or a used one for little money. Since Jarnal is written in Java, you must have the Java Runtime Environment installed on your machine in order to use it. Once you've done all the preparatory work, download the latest release of Jarnal, unzip it, and run the jarnal.sh script.
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Microsoft Frees Code for .NET Build Engine
MSBuild is now just another GitHub project as Redmond continues its path to the light.
Researchers Demonstrate Hack by Heat
Malware could pass data and commands between disconnected computers without leaving a trace on the network.
Kernel Developers Adopt Code of Conflict
New rules emphasize collegiality in coding.
Ubuntu Switches to systemd
Upstart lands in the dust bin as a new era begins for Linux.
Old Vulnerabilities Are Kept Alive Through Bad Configuration
HP's annual Cyber Risk report offers a bleak look at the state of IT.
Linus Torvalds Announces Linux 4.0
But what do the big numbers really mean?
Microsoft Frees CoreCLR
.NET Core execution engine is the basis for cross-platform .NET implementations.
New Trojan Attacks Linux Servers
The Xnote trojan hides itself on the target system and will launch a variety of attacks on command.
Cisco Releases Annual Security Report
Spammers go low-volume, and 90% of IE browsers are unpatched.
Zero Day Exploits Target Flash
Adobe scrambles to release patches for vulnerable Flash Player.


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Heartburn? Try Sleeping On Your Left Side
However strange one might think it that the president of the United States was first reported to have been sent to the hospital today for "a sore throat" and afterwards was diagnosed with "acid reflux," it seems an opportune time to share a bit of knowledge I wish someone had shared with me much sooner.
In particular, this piece of advice ought to be shared on every bottle of TUMS® or ROLAIDS® or PEPCID® AC® or [fill in your own preferred over-the-counter antacid preparation]. Informing people of this, however, would necessarily reduce the sales of such substances; so, even in the information age, this information is not very commonly available. [Read more →]


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Note: By default, domains registered with 1&1 are placed under "Domain Lock" protection. This is to prevent unauthorized transfers of your domain. Before your domain transfer is requested, the domain must be unlocked, and your registry status confirmed as "Active".
- Log in to your account at https://admin.1and1.com.
- Under "Domains & Web Space", click "Domains."
- Click the "Transfers" button.
- In the "Transfers" cpr144449003101 dropdown, click "Lock/Unlock."
- On the next page, select the domain to be unlocked from the dropdown menu, then click "Next."
- Click the button next to "Unlock", then click "OK."
- Note: It may take up to 24 hours for the system to recognize the status change before your domain can be transferred.


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Fit and Healthy with Marilu Henner Video
Marilu Henner chats about healthy living and how she stays fit!
What Do You Think?
4 Beauty Geniuses Reveal Their Holy Grail Products
Plus their secrets to looking flawless.
Show Your Allegiance to the Beyhive With Beyoncé's New Nail Wraps
For truly ***flawless fingers.
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Kardash cleavage for all!
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