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Publications (66)208.64 Total impact
Contact Dermatitis 02/2007; 39(6):331 - 331. DOI:10.1111/j.1600-0536.1998.tb05966.x · 3.62 Impact Factor
Contact Dermatitis 04/2006; 23(4):236 - 236. DOI:10.1111/j.1600-0536.1990.tb05011.x · 3.62 Impact Factor
Article: Erythema multiforme during cytomegalovirus infection and oral therapy with terbinafine: a virus-drug interaction[Show abstract] [Hide abstract]
ABSTRACT: The authors report a case of erythema multiforme in a 32-year-old woman who was also taking oral terbinafine for an onychomycosis. The patient data analysis showed serological positivity for cytomegalovirus (IgM and IgG) and hepatitis C virus and serological titre of antinuclear antibody was elevated. After a brief review of the literature the authors propose the possibility of virus-drug interaction as a model of adverse drug reactions.Journal of the European Academy of Dermatology and Venereology 04/2004; 18(2):201-3. DOI:10.1111/j.1468-3083.2004.00806.x · 3.11 Impact Factor
Article: Acute generalized exanthematous pustulosis in cystic echinococcosis: immunological characterization[Show abstract] [Hide abstract]
ABSTRACT: We report the first case, to the best of our knowledge, of a woman suffering from cystic echinococcosis of the liver, who consequently developed urticaria and acute generalized exanthematous pustolosis (AGEP). Serum immunoglobulin (Ig)E and IgG4 specific to Echinococcus granulosus antigens were detected by immunoblotting. Furthermore, the intracellular cytokine analysis revealed a prevalent T-helper 2 polarization. It can be reasoned that, while the presence of IgE specific to various E. granulosus allergens may be responsible for the chronic urticarial manifestations, the detection of IgG4 specific for E. granulosus antigens, forming immunocomplexes, may be related to the development of the AGEP.British Journal of Dermatology 07/2003; 148(6):1245-9. DOI:10.1046/j.1365-2133.2003.05346.x · 4.10 Impact Factor
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ABSTRACT: Eyelids can be affected by various types of dermatitis that are often difficult to diagnose. The aim of the study was to establish some guidelines for a correct diagnosis. A total of 447 patients treated at 12 research units for eczema or other inflammatory dermatitis located on the eyelids were invited to complete a questionnaire. When necessary, patch tests with haptens of the standard series from Gruppo Italiano di Ricerca sulle Dermatiti da Contatto e Ambientali della Società Italiana di Dermatologia e Venereologia (SIDEV-GIRDCA) were performed. Of the subjects studied, 50.2 % were diagnosed with allergic contact dermatitis (ACD); 20.9% were affected by irritant contact dermatitis (ICD), 13.5% by atopic dermatitis, 6.3% by seborrheic dermatitis, 6.5% by aspecific xerotic dermatitis, and 2.3% by psoriasis. Approximately 91% of all subjects reported an absence of familial atopy. A significant statistical association between diagnosis type and a personal history of atopy was evident (p <.000001, chi-square test). The results of gradual logistic regression models showed four-eyelid involvement as the main risk factor for ACD (odds ratio [OR] = 3.0; 95% CI, 1.1-8.1); with ICD, the main risk factor was the onset of symptoms at between 2 and 6 months (OR = 2.1; 95% CI, 1.1-4.0), whereas for atopic dermatitis, the main risk factors were the onset of symptoms later than 6 months and a personal history of atopy (OR = 4.9 and 3.6, respectively). Results suggest that many characteristics of the patients examined can be used for the differential diagnosis of palpebral eczematous dermatitis.American Journal of Contact Dermatitis 06/2003; 14(2):69-74. DOI:10.2310/6620.2003.38359
Annals of Oncology 04/2003; 14(3):497-8. DOI:10.1093/annonc/mdg092 · 6.58 Impact Factor
Article: Cutaneous response to irritants[Show abstract] [Hide abstract]
ABSTRACT: We evaluated the role of pre-existing dermatitis in the response to irritants by patch testing the skin of 40 healthy volunteers and the uninvolved skin of 480 subjects for 2 days. These latter were affected by active atopic dermatitis, psoriasis, eczema with positive and negative patch test reactions, urticaria and generalized pruritus. A first panel containing 15 micro L of aq. solutions of disodium laureth sulfosuccinate (NaLSS) 5% and 10%, potassium cocoate (KCC) 5%, potassium oleate (KOL) 5%, zinc coleth sulphate (ZnCS) 5%, sodium mireth sulphate (NaMS) 5%, sodium cocoamphoacetate (NaCCAA) 3% and 5%, was simultaneously applied to 1 site on the upper back. The results, scored by visual assessment, were compared to those observed when testing on the opposite side a second panel containing 15 micro L of aq. solutions of 3 well-known irritants, benzalkonium chloride (BAK) 1%, sodium lauryl sulphate (SLS) 1%, and dimethylsulphoxide (DMSO) 10%. Whilst the substances of the first panel and DMSO gave, on the whole, a scarce number of positive responses in all the tested groups, more evident differences in number, percent and mean intensity of the positive responses to BAK and SLS were found between the different groups. Although some of them seemed statistically significant, when the same values were evaluated by means of chi2 and Student t-test, they did not differ in a statistically significant way from the values found in healthy subjects. The results of this study seem to indicate that the substances of the first panel have a chemical structure that makes them quite safe in real-life conditions. In contrast, BAK and SLS have chemical properties that condition the number and intensity of the responses, making the role exerted by the pre-existing dermatosis quite marginal. In particular, there is no proof that the healthy skin of active atopic subjects is the most susceptible to the irritating effects of the tested substances.Contact Dermatitis 03/2003; 48(2):69-73. DOI:10.1034/j.1600-0536.2003.480203.x · 3.62 Impact Factor
Article: Levels of enzymatic antioxidants activities in mononuclear cells and skin reactivity to sodium dodecyl sulphate.[Show abstract] [Hide abstract]
ABSTRACT: Chemical irritants are able to produce several biological modifications of the skin, including the direct or indirect production of cytokines and reactive oxygen species leading to an inflammatory reaction. This report examines the existence of a possible correlation between the skin sensitivity to the irritant sodium dodecyl sulphate (SDS) and the activity of the enzymatic antioxidants. In twenty-three healthy subjects the evaluation of the epidermal and peripheral blood mononuclear cells (PBMCs) activities of Superoxide Dismutase (SOD) and Catalase (Cat) demonstrate a significant correlation (r= 0,85 and p< 0,005 for SOD, and r= 0,87 and p< 0,0001 for Cat). Based on this result, on a further group of normal subjects (n=13) we studied the link between the threshold dose of skin reactivity to SDS and the activities of the enzymatic antioxidants in PBMCs. The degree of skin modification induced by SDS, applied at different concentrations for 24 hrs, was determined by means of Trans Epidermal Water Loss (TEWL), Erythemal Index or by Visual Score (VS). The minimal dose of the irritant capable of inducing skin modifications, was significantly correlated with SOD (r=0,77) and Cat (r=0,81) activities in PBMCs, and the modification of TEWL or EI were inversely correlated with levels of antioxidants in PBMCs (r=-0,62 for SOD and r=-0,66 for Cat). Our results indicate that the skin reactivity to irritants can be modulated by the levels of antioxidants, and suggest a possible therapeutical approach in preventing irritant contact dermatitis.International journal of immunopathology and pharmacology 01/2003; 16(1):49-54. · 2.51 Impact Factor
Article: IgE-mediated allergy to corn: a 50 kDa protein, belonging to the Reduced Soluble Proteins, is a major allergen[Show abstract] [Hide abstract]
ABSTRACT: Although corn is often cited as an allergenic food, very few studies have been devoted to the identification of corn allergens and corn allergy has been rarely confirmed by double-blind, placebo-controlled food challenge (DBPCFC). Recently, Pastorello et al. (1) identified some salt-soluble IgE-binding proteins of corn flour as potential allergens. One of these, corresponding to corn Lipid Transfer Protein (LTP), appeared to be the major one. The aim of this study was to verify the clinical significance of the skin prick test (SPT) and CAP-FEIA CAP-System IgE fluozoenzyme immunosorbent assay (Pharmacia Diagnostic, Uppsala, Sweden) positivities to corn and to identify the presence of IgE-binding proteins in the corn flour salt-insoluble protein fractions (comprising up to 96% of the total protein) using sera of patients with DBPCFC-documented food allergy to corn. In addition the effect of cooking and proteolytic digestion on the corn allergens was investigated. Sixteen subjects with SPT and CAP-FEIA positivities to corn flour were examined. Only six of them complained of suffering from urticaria and/or other symptoms after ingestion of corn-based foods. The patients were food challenged with cooked corn flour (polenta). IgE-binding proteins were detected by immunoblotting. The digestibility of the IgE-binding proteins was examined during a pepsin attack followed by a pancreatin digestion performed on a cooked corn flour sample. Oral challenge was positive only for six patients with symptoms after ingestion of corn. A 50 kDa protein, belonging to the corn Reduced Soluble Protein (RSP) fraction was recognized by the serum IgE of all the DBPCFC-positive subjects and resulted to be resistant to both heating and peptic/pancreatic digestion. SPT with the purified RSP fraction gave positive results for all of the DBPCFC-positive patients examined. SPT and CAP-FEIA positivities to corn flour had no clinical significance for most of the patients and food allergy to corn has to be proved by DBPCFC. A salt-unextractable protein of 50 kDa, belonging to the RSP fraction, represents a potential allergen in food hypersensitivity to corn because of its stability to cooking and digestion.Allergy 03/2002; 57(2):98-106. DOI:10.1034/j.1398-9995.2002.1o3413.x · 6.00 Impact Factor
Article: IgE binding to soluble and insoluble wheat flour proteins in atopic and non-atopic patients suffering from gastrointestinal symptoms after wheat ingestion.[Show abstract] [Hide abstract]
ABSTRACT: The involvement of IgE-mediated hypersensitivity reactions in the genesis of gastrointestinal symptoms after ingestion of foods containing wheat has been rarely reported. To detect IgE specifically binding to wheat proteins in the sera of atopic and non-atopic patients suffering from gastrointestinal symptoms after ingestion of wheat and to evaluate the reliability of skin prick test and CAP in the diagnosis of food allergy to wheat. The sera of patients (10 atopic and 10 non-atopic) previously diagnosed as suffering from irritable bowel syndrome and complaining of symptoms after wheat ingestion were analysed by immunoblotting for IgE binding to water/salt-soluble and insoluble wheat flour proteins. All the atopic patients and only one of the non-atopic patients were positive to wheat CAP. For the patients tested, skin prick test was positive for all the atopic patients and for only one of the non-atopic patients. However, immunoblotting experiments showed the presence of specific IgE to wheat proteins in all the patients. Ten out of 11 of the wheat CAP-positive patients had IgE binding to a soluble 16-kDa band, but the same band was recognized, in a slighter way, by only two out of nine of the wheat CAP-negative patients. Moreover, although almost all of the patients were negative in CAP testing with gluten, 19 out of 20 recognized protein bands belonging to the prolamin fraction. For the atopic patients the positivity to skin prick test and CAP to wheat was in accordance with the immunoblotting results and a food allergy to wheat could be diagnosed. In these patients a major allergen was a 16-kDa band corresponding to members of the cereal alpha-amylase/trypsin inhibitors protein family, the major allergens involved in baker's asthma. In the non-atopic patients the positive immunoblotting results contrasted with the responses of the allergologic tests, indicating that the allergenic wheat protein preparations currently used are of limited value in detecting specific IgE to wheat and that the fraction of irritable bowel syndrome (IBS) patients with food allergy may be larger than believed.Clinical & Experimental Allergy 12/2001; 31(11):1771-8. DOI:10.1046/j.1365-2222.2001.01200.x · 4.32 Impact Factor
Article: Platinum in the environment: frequency of reactions to platinum-group elements in patients with dermatitis and urticaria[Show abstract] [Hide abstract]
ABSTRACT: The aim of the present paper is to evaluate whether increasing environmental exposure increases the frequency of the positive prick and patch test reactions to certain chlorinated platinum salts in patients with dermatitis and urticaria. 800 consecutive subjects with contact dermatitis (n=749) and urticaria (n=51) were variously patch and prick tested with 30 haptens of a standard series, with aqueous solutions of, respectively, hexachloroplatinic acid (H2[PtCl6]), potassium tetrachloroplatinate (K2[PtCl4]), sodium hexachloroplatinate (Na2[PtCl6]), iridium chloride (IrCl3), rhodium chloride (RhCl3) and palladium chloride (PdCl2), and with 16 common inhalants. 153 workers, variably exposed in a platinum refinery, were patch and prick tested only with solutions containing platinum-group elements at various concentrations and with 16 common inhalants. Platinum-group elements did not elicit positive patch or prick test reactions in non-occupationally exposed subjects. In contrast, in exposed workers, positive patch test reactions at day 2 and at 25 min, respectively, were found in 2 subjects with hand dermatitis and in 2 with urticaria and asthma. 22 out of the 153 workers, 18 of whom had rhinitis, asthma, and urticaria, gave positive prick test reactions to 1 or more salts. Furthermore, on patch and prick testing, 4 cross-reactions between platinum, palladium, iridium and rhodium were demonstrated. In conclusion, the test results demonstrate that the present concentration in the environment does not increase the incidence of reactions to platinum salts in patients with dermatitis and/or urticaria. However, if the average level of environmental platinum exposure approaches those existing in industrial settings in the future, we are going to observe more frequent health effects.Contact Dermatitis 01/2001; 43(6):333-8. DOI:10.1034/j.1600-0536.2000.043006333.x · 3.62 Impact Factor
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ABSTRACT: The present work reports the results of a multicentre study of toothpaste allergic contact cheilitis (TACC) conducted by GIRDCA (Gruppo Italiano Ricerca Dermatiti da Contatto e Ambientali). The study examined 54 patients with eczematous lesions on the lips, the possible cause of which was suspected to be the use of toothpastes. Patch tests were conducted with a standard series, a specially-targeted series (toothpaste cheilitis series, TCS), and with suspected toothpaste(s). A stop-restart test (SRT) was carried out with these, together with a use test to identify possible alternative products. The TCS produced 17 positive reactions in 13 patients, the most frequent being to spearmint oil. Of the 54 patients, 5 displayed positive reactions only to the TCS. The patch tests with toothpaste produced positive reactions in 11/32 patients, the SRT a positive response in 10/12 cases. The diagnosis of TACC was confirmed in 15/54 patients. Alternative products were identified for 5 patients. In conclusion, the allergens most frequently responsible for TACC were the flavourings, and the additional series proved to be useful in many cases (together with patch tests with toothpastes and the SRT) for correct diagnosis and to initiate effective prevention.Contact Dermatitis 11/2000; 43(4):216-22. DOI:10.1034/j.1600-0536.2000.043004216.x · 3.62 Impact Factor
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ABSTRACT: The expression and the distribution of metallothioneins (MT)-I and II isoforms were evaluated in 5 healthy volunteers and in 16 subjects with positive patch test reactions to various compounds. Skin specimens taken both from the healthy skin of the back and at positive patch test sites (at 48 h), were treated using a 3-step indirect immunoperoxidase procedure with a mouse monoclonal IgG1 antibody reactive against I and II isoforms of human, rat and horse MT. MT were expressed in the basal layer of the healthy skin of both controls and sensitive subjects, without any significant difference. At positive patch test sites, there was an overexpression of MT in basal and suprabasal layers of the epidermis. Overexpression of MT, related to the degree of the inflammatory reactions elicited by the penetrating compounds was observed in the dermis. The cells expressing MT in the dermis were mostly T lymphocytes and cells with dendritic morphology which positively stained in part for CD34 and in part for XIIIa markers and negatively for KP1, S100 and HLA-DR. Taken together, these results seem to indicate that MT represent a constitutive mechanism of defence expressed by different types of cells in the skin, which is triggered by contact with both metallic and non-metallic compounds. The biological significance of MT in the skin remains to be elucidated. Our preliminary findings do not permit evaluation of whether these nearly ubiquitous proteins exert their cytoprotective effects in the skin acting simultaneously as antioxidant, metal binding or zinc suppliers, or if they display these activities mainly depending on the nature of the penetrating substances.Contact Dermatitis 09/2000; 43(2):103-6. DOI:10.1034/j.1600-0536.2000.043002103.x · 3.62 Impact Factor
Contact Dermatitis 06/1999; 40(5):281-2. DOI:10.1111/j.1600-0536.1999.tb06066.x · 3.62 Impact Factor
Article: Urticaria from beer: an immediate hypersensitivity reaction due to a 10-kDa protein derived from barley.[Show abstract] [Hide abstract]
ABSTRACT: Urticaria from beer has been reported in atopic patients. In these subjects, the skin-prick test positivity to and presence of specific serum immunoglobulin (Ig)E for barley malt, the basic ingredient used in brewing, suggested a type I hypersensitivity to barley component(s). To identify the beer allergen(s) and to investigate the presence of related proteins in barley. Three patients with urticaria from beer and other atopic people, some of them suffering from baker's asthma, were examined for both prick test sensitivity to and the occurrence of serum-specific IgE for partially purified proteins from beer. Allergen identification in beer, malt and barley was performed by immunoblotting. Skin-prick tests and detection of specific IgE by both solid-phase (RAST) and liquid-phase (AlaSTAT) assays demonstrated that the 5-20-kDa beer protein fraction contained the allergen. Immunoblot analysis with sera of patients with urticaria from beer showed that IgE bound only the 10-kDa protein band in beer and malt, whereas a main 16-kDa protein was revealed in barley in addition to a very faint 10-kDa band. With the serum of a patient suffering from baker's asthma no IgE binding bands were observed in beer, whereas specific IgE binding to several proteins, including a major 16-kDa component, were detected for both malt and barley. Urticaria from beer is an IgE-mediated hypersensitivity reaction induced by a protein component of approximately 10 kDa deriving from barley. This allergen does not seem to be related to the major barley 16-kDa allergen responsible for baker's asthma. Because of the severity of the allergic manifestations to beer we recommend testing atopic patients positive to malt/barley and/or who exhibit urticarial reactions after drinking beer for their sensitivity to this beverage.Clinical & Experimental Allergy 04/1999; 29(3):407-13. DOI:10.1046/j.1365-2222.1999.00491.x · 4.32 Impact Factor
Article: Thimerosal positivities: patch testing to methylmercury chloride in subjects sensitive to ethylmercury chloride.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this paper was to evaluate whether methylmercury chloride (MeHgCl) aq., when patch tested in a group of thimerosal-positive subjects reacting to ethylmercury chloride (EtHgCl), might be a reliable model for the better understanding of interactions between alkylmercury compounds and the skin. 19 out of 21 consecutive patients who previously had given positive patch-test reactions to both ethylmercury chloride 0.0165% eth.(EtHgCl, 0.615 mM) and MeHgCl 0.031% aq.(1.23 mM), and negative reactions to thiosalicylic acid 0.05% (3.24 mM) aq./eth. 50/50, were repatch tested to 8 microl of MeHgCl 0.031% aq. and to 8 microl of aq. solutions containing MeHgCl mixed with cysteine, glutathione, ZnSO4, MgSO4, MnSO4, ZnCl2, MgCl2 and MnCl2, respectively. The results showed that cysteine, glutathione and Zn(II) salts were able to abolish the positive reactions, demonstrating the rôle played by both thiol groups and Zn(II) itself. Patch tests concomitantly carried out in 16 out of 19 patients to 8 microl of aqueous MeHgCl and to 8 microl of aqueous solutions containing MeHgCl and MeHgCl mixed to fragment 56-61 of metallothionein I (MT I), MT I and MT II-Zn, respectively, revealed that all the MTs tested were able to reduce or to inhibit the reactions, demonstrating the effect of the thiol groups. Due to the close chemical similarities to EtHgCl and to its water solubility, MeHgCl seems to be a suitable model for evaluating the reactivity of alkylmercury compounds in the skin. We speculate that both EtHg- and MeHg-derivatives are xenobiotics with similar reactivity. However, the lack of clinical relevance of the reactions to both alkyl compounds lead us to conclude that, since environmental exposure does not seem to play a pivotal rôle, they probably have mostly to do with compounds included in in the standard series, and are elicited by reduced function of physiological SH chelators.Contact Dermatitis 02/1999; 40(1):8-13. DOI:10.1111/j.1600-0536.1999.tb05969.x · 3.62 Impact Factor
Contact Dermatitis 01/1999; 39(6):331-2. · 3.62 Impact Factor
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ABSTRACT: For a better understanding of the mechanistic details of the interactions of organomercury compounds inside the skin, 32 subjects who previously had given positive patch-test reactions to thimerosal (TH) and negative reactions to thiosalicylic acid, were divided into 2 groups. 16 subjects were repatch tested to ethylmercury chloride (EtHgCl) and to solutions containing EtHgCl mixed with L-cysteine and glutathione, respectively. The remaining 16 were repatch tested to EtHgCl and to solutions containing EtHgCl mixed with chlorides of Zn, Mg, and Mn, respectively. The results showed that whilst L-cysteine, glutathione and ZnCl2 were able to abolish or to reduce the positive reactions to EtHgCl, chlorides of Mg and Mn were unable to do so. Patch tests revealed that in causing positive reactions to TH, EtHg probably interacted with thiol groups and with Zn ions, as in biological systems when causing toxic effects. The limited number of TH reactions in the general population, the constant presence of concomitant positive reactions to EtHgCl and MeHgCl, and the lack of cross-reactivity with other organic or inorganic mercury compounds, lead us to speculate that reactions to TH are due to organomercury alkyl compounds, and that positive subjects have a constitutively reduced capability to metabolize organomercury compounds, rather than to reveal previous exposure.Contact Dermatitis 10/1998; 39(3):123-6. DOI:10.1111/j.1600-0536.1998.tb05860.x · 3.62 Impact Factor
Article: The influence exerted by cutaneous ligands in subjects reacting to nickel sulfate alone and in those reacting to more transition metals[Show abstract] [Hide abstract]
ABSTRACT: To study the influence exerted by cutaneous ligands in nickel reactions we have evaluated the patch tests responses to 4 aqueous nickel salts (sulfate, chloride, nitrate, acetate) able to form different complexes with different geometry. Two groups of respectively 71 subjects who previously reacted only to nickel sulfate 5% petrolatum (pet) and of 30 subjects who previously reacted to nickel sulfate 5% pet and to at least 1 other transition metal, were simultaneously repatch-tested to 200 microg of Ni++ contained in nickel sulfate in pet and to 47 microg of Ni++ contained in 4 different aqueous nickel salts. Another 2 groups of 25 subjects with the same characteristics were simultaneously repatch tested to 200 microg of Ni++ in pet and to 12 microg of aq Ni++ as in the first 2 groups. Visual score, total score, and mean value of the reactions were utilized in evaluating the degree of the responses. On testing to 200 microg of Ni++ in pet all the subjects were able to give positive responses. Whilst a higher percentage of the responses of 2+ degrees was found in subjects reacting to nickel sulfate 5% pet alone, a higher percentage of responses of 3+ degrees was observed in subjects reacting to more transition metals. On testing to 47 and 12 microg of aqueous Ni++ a large variability of responses to the single salts was observed in all the subjects. However, in subjects reacting to more metals there were either a greater number of multiple responses to 3 or 4 salts or responses stronger than those found in subjects reacting to nickel sulfate alone. Although patch testing cannot give us complete information about the degree of previous exposure, the results arising from the tests seem to demonstrate that the subjects allergic to nickel and other transition metals are more reactive than the subjects allergic only to nickel to the application of the same amounts of Ni++ contained in different salts. When considering the QSAR model, the difference in the sensitizing potential of the metal at the same penetration properties can depend on the possibility of combining with specific ligands. Therefore, it is likely that in subjects reacting to more metals there is a more uniform availability of cutaneous ligands which conditions the formation of complexes more immunogenic. The arising inflammatory reaction in these cases leads to a stronger but less specific response.Experimental Dermatology 09/1998; 7(4):162-7. DOI:10.1111/j.1600-0625.1998.tb00318.x · 4.12 Impact Factor
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ABSTRACT: Contact allergy to thimerosal (TH) has not been considered a marker for mercury allergy, since there is a low degree of cross-sensitivity to inorganic as well as to organic mercury salts. 40 subjects, who previously gave a positive patch test reaction only to thimerosal 0.1% pet. (Hermal), when simultaneously repatch-tested to solutions containing TH, mersalyl acid, p-amino-phenylmercuric acid, mercuric acetate and thiosalicylic acid, respectively, gave positive reactions only to TH. 36 out of 40 subjects were divided into 2 groups of 18 subjects and simultaneously repatch-tested to solutions containing TH, methylmercury chloride (MeHgCl), thiosalicylic acid, and, ethylmercury chloride (EtHgCl), respectively. EtHgCl was tested in the 1st group at 0.031% and in the 2nd group at 0.015%. The results showed that all subjects gave concomitant positive reactions to TH, EtHgCl and MeHgCl. EtHgCl 0.031% gave a higher number of reactions than EtHgCl 0.015%, underlining the rôle of the solvent in these reactions. Patch test results in 300 consecutive patients to a standard series, to which MeHgCl was added, showed that MeHgCl and TH were never able to give isolated positive reactions, and that the concomitant positive reactions occurred in only 3.6% of subjects. In conclusion, our data seem to suggest that the positive reactions to TH found in our patients were due to EtHgCl, and that the structural similarities with MeHgCl were so close that the skin reacted against each as if they were identical.Contact Dermatitis 07/1998; 38(6):325-8. DOI:10.1111/j.1600-0536.1998.tb05767.x · 3.62 Impact Factor
Top Journals
Istituto Dermatologico San Gallicano - Istituti Fisioterapici OspitalieriRoma, Latium, Italy
University of Milan
Milano, Lombardy, Italy
- Istituto di Scienze Dermatologiche
University of BolognaBolonia, Emilia-Romagna, Italy
The American University of RomeRoma, Latium, Italy


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Tag Archives: Larry Walker
My hypothetical Hall of Fame ballot…2013 edition
They announce the Hall of Fame winners today so I thought I would share my thoughts on the ballot and tell you whom I thought should be elected in. I did this last season and I thought eight players were worthy: Jeff Bagwell, Barry Larkin, Edgar Martinez, Fred McGriff, Mark McGwire, Tim Raines, Alan Trammell, and ...
Posted in Announcement Tagged Barry Bonds, Craig Biggio, Curt Schilling, Edgar Martinez, Jeff Bagwell, Larry Walker, Mark McGwire, Mike Piazza, Roger Clemens, Tim Raines 10 Comments

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Port Welcomes the Expected Arrival of the Sun Ruby
The Sun Ruby, a Weyerhaeuser vessel, is expected to arrive at the Port of Olympia's Marine Terminal on March 29, 2015. After loading cargo (logs), it's scheduled to depart around April 3, 2015.
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Modern Crane Hones Port's Competitive Edge
When Star Louisiana arrived March 1st at Port of Olympia from Antwerp, Belgium, it unloaded a unique Port purchase: a modern 2005 Gottwald mobile harbor crane.
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Port Welcomes the Expected Arrival of the Leo Forest
The Leo Forest, a Weyerhaeuser vessel, is expected to arrive at the Port of Olympia's Marine Terminal on March 14, 2015. After loading cargo (logs), it's scheduled to depart around March 21, 2015.
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Fuel Dock Informational Meeting Set for April 8th
Port of Olympia invites the community to hear about the Fuel Dock Survey, conducted in summer 2014 by Washington State University, Social & Economic Sciences Research Center.
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Plan Will Guide Development of Tumwater Real Estate
Port of Olympia recently kicked off a master plan project that will guide the development of Port-owned real estate in the City of Tumwater, a key project stakeholder. ...
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|Means to actuate jaw(s) (i.e., apply holding force)
|Jaw features
|Means for direct manual adjustment of jaw(s)
|With means to fasten holder to support (e.g., portable)
|With separate means to lock jaw(s) after actuation
|With means for "hold-down" component of force
|Plural jaw pairs
|Plural jaw pairs, angularly oriented, for common work
|With separate positioning means for each of jaw pair
|Lock mechanism for bar clamp - A bar clamp includes a handgrip; a fixed jaw carrier; a slide bar comprising two opposite wing members; a moveable jaw carrier and comprising a transverse channel, a trough extending from center of the channel to one end of the channel, a bottom recess, and two opposite stop members in the recess wherein the slide bar passes the channel with the wing members being stopped by the trough in a locked position; and a U-shaped spring-actuated lock assembly in the recess and comprising inverted U-shaped opposite first and second lock members being engaged with the wing members in the locked position, and first and second projections between the lock members and a bottom of the lock assembly and being engaged with the stop members in the locked position. Pushing the locking assembly until being stopped will disengage the lock members from the wing members.
|Device for applying pressure to a workpiece and clamping tool - A device for a clamping tool for applying pressure to a workpiece is provided, comprising a contacting area for a workpiece, a holding head locating space for a holding head of the clamping tool, and at least one locking element for fixing the holding head in the holding head locating space, which said locking element is arranged in a locking element locating space and must be passed through by the holding head, wherein the at least one locking element and the locking element locating space are formed in such a manner that the amount of force required to pass through the at least one locking element in the direction of insertion of the holding head into the holding head locating space is smaller than the amount of force required to pass therethrough in the direction of extraction of the holding head from the holding head locating space.
|VARIABLE GEOMETRY WORKTABLE - A worktable having a leg supports (
|Adjustable Clamping Device for Stair Assembly - An adjustable clamping device for use in temporarily securing together opposed stairway stringers about one or more stair tread members includes a body member having opposed upper and lower ends. A length adjustable first arm is connected to the body member upper end and a length adjustable second arm is connected to the body member lower end. The clamping device includes a pressure plate having a generally planar configuration and situated parallel to the body member. An actuator having a first portion is operatively coupled to the body member and to the pressure plate to selectively move the pressure plate between retracted and extended configurations. A user input is attached to a proximal end of the actuator by which a user may operate the actuator to move the pressure plate.
|Modular Adjustable Vise - A modular adjustable vise is provided. The modular adjustable vise includes a base and a plurality of vise units mounted to the base. The plurality of vise units are spaced apart. Each vise unit includes a pair of jaws movable toward and away from one another to form an adjustable gap therebetween. Each of the vise units are independently adjustable such that the adjustable gap of each vise unit can be adjusted independent of the gap of the other vise units. A method for configuring a vise is also provided that includes machining a clamping surface of a jaw of the vise unit after the jaw has been mounted to the base.
|With means for lateral adjustment of jaw portions
|Worktable Clamping and Folding Apparatus and Methods for Operating Same - A worktable clamping apparatus wherein an adjustable clamping jaw is operable between an adjustable mode (allowing both forward and backward movement on a supporting frame and a clamping mode whereby a work piece is clamped by opposing jaws. The clamping mode is selectively effected by actuation of a clamping assembly which prevents backward movement of the adjustable clamping jaw away from the work piece to be clamped. The clamping mode is not effected automatically but is selectively effected by the user. The time taken to clamp a work piece is significantly reduced as compared to conventional clamping apparatus. In a further aspect of the invention, the clamping apparatus can be collapsed into a partially deployed state to allow the "A" frame structure to be used for alternative purposes.
|Assembly for clamping a workpiece - An assembly for clamping a workpiece, the workpiece comprised of two pieces. The assembly includes a clamp having an L-shaped member. The L-shaped member has a leg and foot portion. The clamp also has an upright extending generally perpendicularly to the leg and the upright has a threaded portion. The clamp includes a threaded adjuster having a head, a threaded body, and a base. The base includes outer walls defining a polygon shape and handle. The handle has removed ends thereon. The handle has outer walls and inner walls, the inner walls are dimensioned to removably, slideably and snugly engage the outer walls of the base. The handle has more than one set of walls and so can be positioned to apply different torque to the base. A drill, a drill bit, and a socket may also be included in the assembly, to engage the handle and drive the threaded adjuster.
|TILE RETAINING ARTICLE - A tile retaining device that secures a tile or other work piece for cutting is disclosed. The tile retaining device can be used in combination with a circular saw, a wet saw, a band saw, or any other type of mechanical cutting or manipulating device. The tile retaining device secures a tile and provides additional surface area for a user to grasp during the cutting process, which can aid in manually manipulating the work piece through a mechanical cutting or manipulating device. The tile retaining device can also provide cutting guides, and can be adaptable to a variety of shapes and sizes of tiles.
|Quick release electronics platform - A device mounting platform apparatus having a reconfigurable biasing mechanism. The device mounting platform apparatus includes a frame member capable of being mounted in a vehicle and having a device mounting surface facing generally upward. A clamp member is slidably interconnected to the frame member along a first direction. A biasing mechanism is coupled between the frame and clamp members. The biasing mechanism is reconfigurable for urging a jaw portion of the clamp member along the first direction heading either toward or away from the frame member. The biasing mechanism is thus reconfigurable for either urging the clamp member open or urging it closed.
|CLAMP DEVICE - The disclosed clamp device for clamping blank pieces may comprise a mounting table, first and second clamping units, positioning units, and lock units. The mounting table is for placing thereon first and second blank pieces. The first and second clamping units have respective clamp plates that are able to be put on the first and second blank pieces while permitting a guided movement of the first and second blank pieces on the mounting table. The positioning units move the first and second blank pieces to establish a positioning of the first and second blank pieces on the mounting table. The lock units apply a given force to the first and second clamp plates to lock the first and second blank pieces.
|Clamp couple element with fastening means
|ELECTRIC POSITIONING AND CLAMPING APPARATUS - A small-sized electric positioning and clamping apparatus is provided. A panel material is supported on a workpiece supporting face and is positioned by a locating pin being fitted into a positioning hole. A clamp arm is accommodated in a slit formed in the locating pin, and the panel material is clamped by the clamp arm. The clamp arm is coupled to a driven rod, and the driven rod is coupled to a driving rod via a compression coil spring. A cam face is formed in a cam block assembled reciprocably in a gear box, and an engagement cam contacting with the cam face is attached to the driving rod. The cam block is reciprocated by an electric motor via a reduction gear mechanism.
|MOUNTING APPARATUS FOR ELECTRONIC DEVICES - A mounting apparatus for securing electronic devices is disclosed. The mounting apparatus comprises a base; two supports secured to the base; a positioning member located in each of the two supports, wherein the positioning member and each of the two supports are configured to move relative to each other along an axis parallel to a surface of the base, and the positioning member has a tooth-faced side with a plurality of first teeth; a securing member having a plurality of second teeth, wherein the securing member is adapted to engage with the positioning member by meshing the plurality of second teeth and the plurality of first teeth, and the securing member is slidable towards the base along the position member; and two resilient members located in each of the two supports, wherein the two resilient members maintains engagement between the plurality of first teeth and the plurality of second teeth.
|FLEXIBLE SUBSTRATE TENSIONER - Apparatus and method to aid in the reproducible and reversible tensioning of flexible substrates, such as polyimide or other file, to ensure planarity before, during, and after processing while mounted in tensioning apparatus.
|Swing Clamp Apparatus - A swing clamp apparatus is provided in which the clamp arm is positioned and attached to a clamp rod at a desired position in a simple and reliable manner and the clamp arm replacement workload is certainly reduced. The swing clamp apparatus comprises an attachment block fixed to the leading end of a clamp rod and to which a clamp arm is detachably attached and a pair of clamping force transmission pins inserted in the attachment block and clamp arm in the direction parallel to the orthogonal direction to the axis for coupling the positioned clamp arm to the attachment block in an integrated manner.
|FLANGED MATERIAL AND STANDING SEAM CLAMP - A clamping assembly for attaching loads to various kinds of flanged seams, the assembly comprising a generally U-shaped clamp body, at least one clamping hammer disposed interior of the clamp body, the clamping hammer being hingedly secured to the clamp body along the longitudinal axis of the clamp body, at least one adjustment screw extending through the clamp body and adapted to selectively impinge against the clamping hammer and cause it to pivot about its axis, the adjustment screw extending transverse to the longitudinal axis of the clamping hammer, at least one locking screw adapted to selectively impinge against the clamping hammer to prevent pivoting of the same whereby a standing seam received within the clamp body may be tightly grasped between the clamp body and the clamping hammer under action of the adjustment screw and then locked into place by the locking screw.
|Specific means for wear, strain, protection, assembly
|DEVICE FOR REMOVING CLAMPING BLOCK MADE OF RESIN AND DEVICE FOR CLAMPING CLAMPING BLOCK MADE OF RESIN - When, while a resin-made clamping block molded to cover a part of a turbine blade is placed on a seat part, paired sliders disposed on opposite sides of the seat part are made to move closer to the resin-made clamping block, paired wedge members provided respectively on the paired sliders engage with notches formed respectively in paired side surfaces, opposed to each other, of the resin-made clamping block to generate cracks. Accordingly, it is possible to divide the resin-made clamping block into at least two pieces and to reliably remove the resin-made clamping block from the turbine blade. Furthermore, since the resin-made clamping block is not broken by a mechanical strike, there is no fear that the turbine blade might be damaged due to an erroneous setting of the strike force.
|HOLDER FOR SPOT WELDER TIP DRESSER WITH ADJUSTABLE CUTTING RATE - The present invention relates to a tip dresser for a welder with a new structure capable of automatically correcting a repeated-position tolerance and a setting error of an industrial robot so that a tip center of a spot welder mounted at the robot coincides with a bite center of the tip dresser in an initial state, and further preventing a bite from being separated by slight force during operation in a state in which the bite is securely fixed. The present invention provides the tip dresser for the welder including a body
|CLAMP ASSEMBLY - A lever-operated clamp having a base, a clamp arm pivotally mounted to the base, and a lever which, upon pivoting, moves the clamp arm in a clamping direction of movement. An internally threaded bolt retainer is mounted to the clamp arm and threadably receives a bolt so that the rotational position of the bolt relative to the bolt retainer varies the position of the bolt relative to the clamp arm. A jam nut or internally threaded knob locks the bolt at its adjusted position.
|Replaceable jaw carriers of bar clamp with adaptable jaws - A bar clamp includes a slide bar; a housing mounted on the slide bar; a rear handgrip extending from the housing; a forward trigger handle extending from the housing, a sliding block releasably mounted on the slide bar in front of the housing; a fixed jaw carrier having an adaptable first jaw at one end; a moveable jaw carrier having an adaptable second jaw at one end; a first coupling mechanism for releasably securing the housing to the fixed jaw carrier; and a second coupling mechanism for releasably securing the sliding block to the moveable jaw carrier.
|Jaw actuation locks holder position relative to base
|PIPE STAND WITH ACCESSORIES - A pipe stand able to support a conduit includes a table having a first surface, supports pivotably coupled to the table for supporting the table in an elevated position with respect to the support surface, and a shelf extending between the supports and positioned between the table and the support surface. At least one of the supports includes an electrical connector, and a power cord is in electrical communication with the electrical connector and connectable to an external power source. The pipe stand includes a first jaw extending from the first surface of the table and shaped to engage a portion of the conduit, and a second jaw a second jaw extending from the first surface of the table and spaced a distance from the first jaw, the second jaw shaped to engage another portion of the conduit. A clamping device is supported by one of the first jaw and the second jaw. The clamping device includes a cord removeably coupled to the table and engageable with the conduit and a winch for biasing the cord with respect to the conduit.
|Clamping device - A clamping device that can reduce a burden on a worker and can surely fix an object includes a basic body, a pressing section for pressing a workpiece, a manually operable operating section, and a transmitting body. The transmitting body transmits a movement of the operating section to the pressing section so that the pressing section travels between a pressing position, at which the pressing section presses the workpiece, and a standing-by position, at which the pressing section is spaced apart from the workpiece to stand by. The basic body has a second opposing section opposing a first opposing section which belongs to the transmitting body. The second opposing section has a pressurizing member resiliently urged in a direction in which the pressurizing member goes from the second opposing section toward the first opposing section. The first opposing section has a pressurized surface which the pressurizing member pressurizes. The pressurized surface has a first depression which the pressurizing member is on the point of entering when the pressing section is placed at the pressing position.
|CLAMP APPARATUS - The present invention relates to a clamp apparatus equipped with a cylinder mechanism having a piston. A driving force of the cylinder mechanism is transmitted to a clamp arm, which is retained on a housing through a block body and a link pin that make up a driving force transmitting mechanism, the clamp arm being rotated through a predetermined angle. The block body includes a rotatably supported roller. The block body is guided along an axial direction by displacement of the roller, while the roller is rotated along a guide member of the housing.
|Handling Device and Method for the same - A handling device and method utilizes a clamping arm that is mounted on a guide rod. The axial direction and the rotation direction of the guide rod are intersected each other at right angles. Makes the clamping arm rotate in the rotation direction of the guide rod when the clamping arm is not restricted, and makes the clamping arm move in the axial direction of the guide rod when the clamping arm is restricted. By such arrangements, the clamping arm can perform handling in the horizontal direction and in the vertical direction.
|With tool couple element
|CLAMPING DEVICE FOR WORKPIECES WITH DIFFERENT SIZES - A clamping device for clamping a workpiece includes a support member, sliding members and a rotating member. The support member is configured for supporting the workpiece. The support member defines cutouts in a periphery thereof. The sliding members each is positioned in one of the cutouts. Each of the sliding members has a cam pin. The rotating member is rotatable relative to the support member. The rotating member defines cam slots on top thereof. The cam pins are received in the cam slots and slidable in the cam slots. Positions of the sliding members are changeable along radial directions of the support member when the rotating member is rotated.
|VISE PROVIDED WITH A MOVABLE JAW DEVICE HAVING SEPARATED APPROACHING AND CLAMPING STEPS IN A PIPE BENDING MACHINE DIE - A vise provided with a movable jaw device having separated approaching and clamping steps in a bending machine die, the vise (
|CLIP FOR COUPLING A SURGICAL TOOL AND SCOPE - A clip for coupling a surgical tool and a scope. The clip includes a first grip having a first radial center and a first diameter, the first grip is configured to engage an outer surface of the tool. Additionally, there is provided a second grip having a second radial center and a second diameter, the second grip is configured to engage an outer surface of the scope. Further, the second grip may be provided between the first grip and a bottom opening of the clip; and the first and second grips may be provided next to each other such that the first radial center of the first grip is radially spaced from the second radial center of the second grip. Additionally, the first diameter of the first grip may be larger than the second diameter of the second grip.
|With means to bias jaw(s) toward nonholding position
|CLAMP FOR A KEY CUTTING MACHINE - Clamp for key cutting machines, of the type comprising a pair of jaws (
|CLAMPING CHUCK - In a clamping chuck (
|With means to orient actuating force on jaws
|CLAMPING MECHANISM AUTOMATICALLY ADAPTABLE TO CHANGE OF THICKNESS OF PRINTED CIRCUIT BOARD - A clamping mechanism automatically adaptable to change of thickness of printed circuit board includes: a frame body having two parallel rail seats; two clamping rail members respectively mounted on the rail seats for clamping a printed circuit board, each clamping rail member including a first clamping rail and a second clamping rail spaced from each other by a clamping gap; and two adjustment units for adjusting the clamping gap of the clamping rail members. Each the adjustment unit includes: a support section mounted on the frame body to provide a support face; a connection section, one end of the connection section being affixed to the first clamping rail, the other end of the connection section being positioned above the support face; and a floating section positioned between the connection section and the support section and supported on the support face to apply a resilient support force to the connection section.
|Including constrictable loop (strand or articulated) jaw
|Workpiece clamping device - A workpiece clamping device for clamping a workpiece during machining is provided. The workpiece may be a turbine blade in the region of the blade airfoil. The workpiece clamping device includes a basic body with a workpiece seat, wherein provision is made for at least one clamping strap for clamping the workpiece.
|Weight of a vertically disposed panel actuates jaws
|Automatic workpiece clamp and support - An automatic clamping device is disclosed for holding planar workpieces such as: doors, windows, panels, plasterboard, etc. The planar workpiece is held in an upright position by clamping jaws actuated by the weight of the workpiece. Automatic clamping is accomplished by placing the workpiece through a slot at the top of the clamping device and lowering it onto a flexible strap connected to movable jaws which, under the weight of the workpiece, move laterally towards and clamp the workpiece. The workpiece is released by simply lifting it up through the slot and coil springs will automatically return the jaws to an open position. The device also provides support for holding planar workpieces on an incline.
|With means to align coacting jaw faces
|CLAMPING FIXTURE - A clamping fixture is provided for mounting work pieces. The clamping fixture includes a base, a supporting member, a covering member, and a positioning member. The supporting member and the positioning member are attached to the base. The work piece is clamped by the covering member and the supporting member. The positioning member is used for changing its position with respect to the base and fixedly mounted thereby for abutting against the work pieces.
|Specific material(s) used for holder
|Method for Manufacturing Frame of C-Clamp, Frame of C-Clamp and C-Clamp - A method comprises manufacturing a frame of a C-clamp, which has a lower jaw, an upper jaw and a mouth between the lower jaw and upper jaw. The method comprises forming a lower end plate and an upper end plate and at least two frame plates, which have a lower branch and an upper branch. The lower branches of the frame plates are attached to the lower end plate and the upper branches to the upper end plate, so that the frame plates settle in a parallel manner at a distance (e) from each other. The joined frame plates and end plates form the frame of the C-clamp. The frame plates are formed by machining a steel plate of ultra-strength steel only with machining methods, which do not substantially heat up the material being machined. Suitable machining methods are for example chipping machining methods or water cutting. The lower branches are attached to the lower end plate and the upper branches are attached to the upper end plate by welding or with mechanical attaching means. The attaching point of the end plates is situated as far away as possible from the most stressed point in the frame plates, so a localized decrease in strength in the ultra-strength steel possibly caused by the welding does not affect the total strength of the frame in a decreasing way. The number of frame plates can be selected according to the strength requirements of the frame. There can thus be for example three, four, five, six, seven or eight frame plates.
|Convertible to other type or form of holder
|Apparatus for Connecting Two Vises to Each Other - An apparatus is disclosed for connecting a bar of a vise to a bar of another vise. The apparatus includes a sheath and two fastening units. The sheath includes two cavities each axially defined in an end thereof and two apertures defined therein transversely and each in communication with a related one of the cavities. Each of the fastening units can be inserted in a related one of the apertures of the sheath and an aperture defined in the bar of a related one of the vises, thus connecting the bars to each other.
|With paralleling mechanism for jaws
|Pipe holding or manipulating tool - A pipe tool with a base unit and peripheral components for holding or manipulating pipe sections. The peripheral components allow the pipe tool to be configured for holding pipes of various sizes in alignment so they may be welded at a seam. The tool can also be reconfigured for changing the cross sectional shape of a deformed pipe end or for spreading open objects such as valve or pipe flanges.
|Three coacting work grippers
|CLAMP ASSEMBLY - A clamp assembly including a header assembly with first and second ends and a plunger having an aperture with a portion of the aperture being threaded, the aperture forming a portion of a bore extending through the header assembly. First and second arms, in opposing spaced relationship, are connected to the first and second ends, respectively, of the header assembly. A ram assembly having first and second ends, each end having a passageway through which at least a portion of one of the first and second arms extend. A stem assembly including an upper stem end coupled to a handle, a lower stem end rotatably connected to the ram assembly, and a threaded stem portion designed to engage the aperture threaded portion. The plunger has engaged and disengaged positions in which the aperture threaded portion and the threaded stem portion are threadedly engaged and disengaged, respectively, with each other.
|Including pivoted yoke frame jaw carrier
|QUICK ADJUSTABLE CLAMP - A quick adjustable clamp includes a first clamp jaw, a second clamp jaw, a driving screw and a nut. The second clamp jaw is extended with a receiving section. The receiving section is formed with a notch facing the first clamp jaw. The driving screw has one end pivotally connected to the first clamp jaw. The nut is mounted around the driving screw and configured to be movably received in the notch. For quick adjusting a span of the clamp, the nut can be removed from the notch, quick moved along the driving screw, and then reengaged by the notch.
|WORKSTATION WITH A MULTIPLE-FACE PARTS SUPPORT, AND A METHOD OF CONTROLLING SUCH A WORKSTATION - The invention relates to a robotic workstation (
|APPARATUS FOR APPLYING MULTI-AXIAL INERTIAL FORCE - Disclosed herein is an apparatus for applying multi-axial inertial force, the apparatus including: a lower support plate; two first support members fixed to stand up from the lower support plate; a second support member positioned to be orthogonal to inner sides of the two first support member in a stand-up direction thereof and rotatably coupled to the first support member; and a third support member stacked on the second support member and coupled to the second support member so as to be rotatable based on a rotational axis corresponding to a stacked direction. Therefore, it is possible to obtain an apparatus for applying multi-axial inertial force in which vibration excitation and rotation may be performed in multiple-axes directions using a uni-axial inertial force generator that may be vibration-excited and rotated only in a single direction.
|METHOD FOR REDUCING VIBRATIONS OF A MACHINE ELEMENT AND/OR OF A WORKPIECE - The invention relates to a method for reducing vibrations of a machine element (
|HOOK PORTION OF CLAMP METER - A clamp meter has a main body and a stationary jaw fixed to an end of the main body. A hook portion of the clamp meter includes a movable jaw, a displacing means and a knob. The movable jaw is mounted on the main body corresponding to the position of the stationary jaw. The movable jaw and the stationary jaw together form a closed loop. The displacing means is mounted in the main body and comprises a displaceable rod connected to the movable jaw and a gear set for driving the displaceable rod. The knob is connected to the gear set for driving the displaceable rod and the movable jaw for linear displacement. The movable jaw is activated by the displaceable rod to generate a linear displacement, so that the user can operate the clamp meter more easily for measurement.
|ADAPTER FOR A MAGNETIC CLAMP - An adapter (
|ENDOSCOPE CHANNEL SEPARATOR - A decontamination system including a test fixture configured to engage an endoscope in order to retain the test fixture thereto, wherein the endoscope can comprise a valve chamber and a valve removable from the valve chamber such that the test fixture can be inserted therein. The test fixture can comprise, first, a frame having a first gripping portion and a valve member analogue extending from the frame, and, second, a housing having a second gripping portion movable relative to the frame between a locked position and an unlocked position, wherein the second gripping portion is configured to be moved toward the first gripping portion to position the housing in its unlocked position. The second gripping portion can be configured to be moved away from the first gripping portion to position the housing in its locked position such that the housing can engage a locking feature on the endoscope.
|MOVABLE WORK PIECE CLAMPING MECHANISM - Embodiments of the invention comprise a clamping mechanism for securing a work piece on a power tool having a working surface and a guide fence, the clamping mechanism including a support configured to be movable along the guide fence and a clamp interconnected to the support, the clamp being movable between a securing position and a release position, wherein in the securing position, the clamp engages a work piece, and in the release position, the clamp is disengaged from the work piece.
|SLIDE EXTENSION LOCATING SYSTEM FOR A CLAMPING APPARATUS - An extension slide locating system for a press-and-pull clamping apparatus designed with slide insertion length adjustable depending on the specification of a work piece is essentially comprised of an extension slide and a slide inserted to each other; an insertion holder connected to the front end of the extension slide; a locating sleeve inserted to the insertion holder; locating sleeve being pushed to be inserted into the locking notch containing the insertion holder prevents the slide from being disengaged from the insertion holder to firmly maintain the insertion configuration in coping with the clamping operation among work pieces in different specifications.
|APPARATUS FOR FINAL FINISHING A WHEEL HUB OF A KNUCKLE ASSEMBLY AND RELATED METHOD - A fixture for final finishing flange faces of a hub of a knuckle assembly includes a mounting surface, a drive arrangement and a clamping arrangement. The drive arrangement is operative for engaging and rotating the hub of the knuckle assembly relative to the remainder of the knuckle assembly. The drive arrangement includes a drive member extending along a drive axis. The drive member is rotatable about the drive axis. The clamping arrangement is carried by the mounting surface. The clamping arrangement radially surrounds the drive arrangement and is operative for clamping the fixture relative to the mounting surface. The clamping arrangement includes a housing, a piston assembly radially positioned between the housing and the drive member, and a clamping sleeve radially disposed between the piston assembly and the clamping sleeve. The piston is movable in a first direction generally parallel to the drive axis. The clamping sleeve and the piston are cooperatively configured to radially force an upper end of the piston assembly radially outward in a second direction in response to movement of the piston in the first direction for engaging a back bore of the knuckle assembly.
|CARBON FIBER CLAMPING APPARATUS AND METHOD - Clamping apparatus and methods are provided. The apparatus can include a rigid backing member having a plurality of apertures disposed therethrough. The apparatus can further include a spring member having a plurality of radial members each having a first end and a second end. The first end of the radial members can be connected at a hub. The second end of each radial member can be connected to a flange. A plurality of apertures, corresponding to the plurality of apertures in the backing member, can be disposed about the flange. The radial members can be fabricated using two or more plies of resin-impregnated carbon fiber. The spring member can be affixed to the backing member using one or more fasteners disposed in the backing member apertures and corresponding aperture disposed in the flange.
|Clamp Instruction Method - A clamp of less waste instruction method for an addition axis, which omits instructions for clamping and unclamping and working in response to those instructions, includes the steps of, at a stage of working a work piece with a tool, measuring a rotational torque generated by the working with respect to the addition axis coupled to a table which supports the work piece or a pallet having the work piece mounted thereon; and generating a clamp instruction to the addition axis when the rotational torque exceeds a predetermined reference value.
|Devices and methods for holding an intraocular lens during the processing and packaging of the intraocular lens - A holder for an intraocular lens during the processing and packaging of the intraocular lens. The holder having an upper member having a base portion extending from the upper member along a first longitudinal axis. Additionally, the holder has a lower member having a receiving member defining a cavity for receiving the intraocular lens and a coupling member for engaging the base portion. The receiving member extending from the lower member along a second longitudinal axis and having at least one channel extending substantially through the receiving member that is substantially transverse to the second longitudinal axis. The holder has a locked position such that the upper and lower members are locked with respect to each other and at least one channel provides unobstructed access into the cavity of the receiving member for obtaining dimensional and optical measurements of the intraocular lens when the holder is in the locked position.
|CONNECTOR - A connector including a spacing link, and a first engagement member connected directly or indirectly to the spacing link, and a second engagement member mounted on an extension arm characterised in that the extension arm is mounted with respect to the spacing link so that the extension arm can move from one side of the spacing link to another.
|WAVE TYPE LINEAR MOTION MECHANISM AND HOLDING MECHANISM - In a wave linear motion mechanism (
|WORKPIECE CARRIER - A workpiece carrier comprises a base with an upper part rotatable about a vertical axis and a lower part connected to the upper part at a distance by bolts. Workpiece holders each comprise a sleeve of elastically deformable material like rubber surrounding a duct where the shaft of a workpiece can be inserted, the sleeve being accommodated in a recess on the base. The vertical position of the sleeve which extends through holes in the upper part and lower part of the base, respectively, is fixed by a stop formed between a recessed rim surrounding the hole in the lower part and a downward-facing projecting rim of the sleeve. The shaft can be fixed by swivelling a lever about one of the bolts into an active position where a compressing surface of the same compresses the sleeve such that the shaft is jammed and released by swivelling the lever back into an inactive position where the compressing surface is not in contact with the sleeve.
|Part Fixturing Systems Having Expanding Clamping Devices - A part fixturing system for securing a workpiece includes an expanding clamping device and a work holding device. The expanding clamping device includes a clamp base portion, first and second traversing wedge blocks, an actuation screw, and a clamp plate portion. The clamp base portion comprises a longitudinal recess, and the traversing wedge blocks are located inside the longitudinal recess, each block including an inclined contact surface and a threaded aperture. The actuation screw passes through the longitudinal recess of the clamp base portion and the threaded apertures of the traversing wedge blocks. The clamp plate portion comprises first and second declined contact surfaces. The work holding device comprises first and second support columns that define a longitudinal loading envelope. The expanding clamping device is positioned inside the longitudinal loading envelope of the work holding device and couples the workpiece to the first and second support columns.
|Work support - Work support arrangements
|LIFE ENHANCEMENT OF RING ASSEMBLY IN SEMICONDUCTOR MANUFACTURING CHAMBERS - The present invention generally relates to a ring assembly that may be used in an etching or other plasma processing chamber. The ring assembly generally includes an inner ring and an outer ring disposed radially outward of the inner ring. The inner ring will correspond to the location where the majority of erosion occurs during use. This inner ring can be flipped and reused until both sides have eroded beyond their service life. Collectively, the two rings generally have the shape of a single piece ring, but the service life of the ring assembly is longer than a conventional single piece ring.
|Methods, Systems, and Products for Welding Grounding Rods - Methods, systems, apparatuses, and products are disclosed for welding ground wires to a grounding rod. A jig retains the ground wires to the grounding rod. The jig has a first horseshoe oriented to a second horseshoe to form a crucifix. Each horseshoe has a pair of legs supporting the jig from earth and providing electrical ground to the earth. A central passage bisects each horseshoe through which the grounding rod inserts. Means are included for clamping a ground wire to at least one of the legs, such that the ground wire is retained for welding to the grounding rod.
|Manufacturing System And Methods - In one aspect, a manufacturing system is provided having lobe clamps configured to secure lobes of a spider, drive assemblies configured to pivot the lobe clamps, sensors for detecting the position of the lobe clamps, and a control system operably coupled to the drive assemblies and configured to cause the drive assemblies to pivot the lobe clamps and impart a twist to lobes of the spider. In another aspect, a method is provided that includes twisting lobes of a spider in a first direction toward initial target positions using a machine, permitting the lobes to twist in a second direction toward free state positions, and twisting one or more of the lobes using the machine in response to the one or more lobes having free state positions different than final target positions of the lobes.
|Piping Slider - A piping slider includes: a cavity in which a pipe-shaped part of an adherend is accommodatable; a slit that intercommunicates the cavity with an outside; a connector to which a belt is connected; a grip member in which the cavity and the slit are provided; a key member insertable into the slit; and a lock mechanism that restricts a displacement between the key member and the grip member when the key member is inserted into the slit, where an opening width of the slit is greater than a minimum width of the pipe-shaped part, and an opening width when the key member is inserted to the slit is smaller than the minimum width of the pipe-shaped part.
|Devices for Capping Vials Useful in System and Method for Dispensing Prescriptions - A method for securing a closure on a cylindrical container (such as a pharmaceutical vial) includes: positioning a closure in a first position, the closure being substantially centered via a centering assembly along an axis that is generally normal to the closure; translating the substantially centered closure along the axis to a second position; positioning a cylindrical container, the container being substantially centered via the centering assembly along the axis; translating the substantially centered closure along the axis to a third position in which it is adjacent the substantially centered container; and relatively rotating the closure and the container to secure the closure to the container. With such a method, both the closure and the cylinder can be centered along the axis, thereby registering them with each other for reliable securing.
|Apparatus for holding a measurement object in a reference position - An apparatus for holding a measurement object, particularly an auto body component in a reference position, comprises a clamping device, which can be attached to a carrier head, and which extends over the measurement object and holds it against the carrier head, and comprises a clamping element that can be placed against the measurement object. The clamping device comprises a lockable slide for adjusting the position of the clamping element.
Patent applications in class RELATIVELY MOVABLE JAWS
Patent applications in all subclasses RELATIVELY MOVABLE JAWS


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MotorTrend's Top 16 Hottest New Coupes: MINI Cooper S Coupe
The longterm MotoringFile JCW Roadster won the hearts of all who drove it until it recently left the MotoringFile Garage to make way for its new big brother, the 2014 Cooper S hardtop. As much adoration as has been heaped onto the niche Roadster/Coupe pair, sales have waned slightly in 2014 with the pair being down 52.9%/54.4% YTD compared to 2013. But yet even in the shadow of the F56 launch, there is still much to love about of the Roadster and Coupe to the point that MotorTrend just named the Coupe one of the "Top 16 Hottest New Coupes on the Market".
"After experiencing the Mini Coupe for a full year, we came away praising its funky interior and goofy attitude. The Mini Coupe is a car that does not take itself seriously, something quite refreshing in 2014. Its polarizing style, racy attitude, and nearly infinite factory customization options make this a popular car for drivers of all ages, though it's not clear whether it will ever see a second-generation model."
So while the future of the Roadster and Coupe may not be certain, for those who choose to partake in it's "refreshing" yet "goofy" demeanor, the rewards will be high [and rather exclusive].
Be sure to check out MotorTrend's long-term 2013 MINI Cooper S Coupe verdict if you previously missed it:
"The Coupe succeeds in getting the attention for which it strives. Big, serious supercars get big attention, too, but a different kind. This Coupe makes people interested, but it also makes them smile."
Written By: Jason Williams
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MINI Model Cheat Sheet
R50: One & MC Hatch
R52: All 1st Gen MINI Convt.
R53: MCS Hatch
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R55: Clubman
R56: Hatch
R57: Convertible
R58: Coupe
R59: Roadster
R60: MINI Crossover
R61: MINI Crossover Coupe
3rd Gen MINI
F54: Clubman
F55: Five Door Hatch
F56: Hatch
F57: Convertible
F60: MINI Crossover
F58: Traveller
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MotoringFile Buyers GuidesR50 ('02-'06 MC) Buyers Guide
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MotoringFile ReviewsReviews:
'12 JCW Coupe
'11 Fiat 500 Sport
'11 Tesla Roaster 2.5 '11 Countryman Comparo
'11 Cooper S Hatch
'11 Countryman MCS (FWD)
'11 Countryman MC (auto)
'10 Mayfair MCS (auto)
'11 Countryman MCS (ALL4)
'10 Tesla Roadster Sport
'09 Cooper S Convertible
'09 JCW Hatch
'09 JCW Clubman
JCW Stage I vs JCW Stage II
'08 Clubman S (Auto)
1st Drive: '08 MINI Clubman
'08 Smart Fourtwo
Comparison: '08 BMW 135i
'06 R53 MCS vs '07 R56 MCS
'07 R56 JCW (Stage 1)
'07 MINI Cooper S Long Term
'07 BMW Z4 M Coupe
'07 MINI Cooper & Cooper S
Audio: '07 MC/MCS at the Track
'06 JCW GP Long term
Reader Review: JCW GP
'06 JCW Cooper S Long Term
Comparison: '06 Lotus Elise
Comparison: '06 Mazda MX5
Comparison: '06 UK Focus ST
Comparison: '06 Civic Si
Comparison: '04 TVR T350
Comparison: '06 Nissan 350z
Comparison: '06 VW GTI w/DSG
Podcast: Cooper S Auto
Podcast: BMW 325i
Podcast: JCW MC Soundkit
'04 JCW MINI Cooper Tuning Kit
'05 MCS: One Month Review
'05 MCS Auto
'05 JCW S 1st Drive
'05 MINI Cooper
'05 MCS Conv. Long Term
'05 MINI Cooper S
'05 MCS Cabrio 1st Drive
'04 JCW MCS First Drive
'04 MC w/JCW Tuning Kit
BMW M3 SMG Vs. MCS
'04 MINI Cooper CVT
'02 MCS 3 year Review
Autocrossing the MINI Range


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my 2 1/2 year old is at preschool/ kindergarten level already
She can count to 20 , knows and recognizes her ABC's, and does flash cards for 4 &5 year olds. My question is do I send her to head start new fall or should I wait. She is the...
Started by April on 08/26/2009 in Moms Of The Highly Gifted
Last update on 09/28/2009 by Tiffany


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Dateful Gred is an uphill mover who is a sporty/athletic type. Has had a chip removed from a hind ankle. Excellent prognosis for athletic career, pending post surgery test ride and a month of slow work.
To learn more about this lovely gelding, check out his page here: Dateful Gred


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PHOTO: Here Is The New Charlie Hebdo Cover, featuring Muhammad.
The issue, expected to be their largest circulation to date at more than three million copies, will be translated into 16 languages.
VIDEO: Local Artist Boy Epic's Awesome Selena Gomez Cover
Share it, hopefully Selena will hear it!
VIDEO: College A-capella Group Does Awesome "Shake It Off" Re-Make!
While not accurate to Taylor Swift's lyrics, this a-capella group from Georgia Tech performed this version to help classmates learn safe party habits.
11-Year-Old Covers 'Shake It Off' And It Could Be The Best One Yet
Sapphire is not your typical 11-year-old who makes videos. This cover of Shake It Off is amazing, and judging from her 64,000 subscribers, we're not the only ones who think so. While many have tried their […]
Climbing A Tree To Sing Bruno Mars Can Be Dangerous
Climbing a tree has some inherent risks. Climbing a tree with a broomstick…definitely risky. Climbing a tree with a broomstick next to power lines in order to sing Bruno Mars? Now, you're just testing fate. […]
Taylor Swift Covers 'Riptide'
I love when artist cover other artist. And this is a good one.
Aretha Franklin Covers Adele AND KILLS IT
Aretha tore down the house Monday night when she covered Adele's Rolling In The Deep. You know it's an amazing performance when David Letterman reacts that way. It's clear: the 72-year-old still has it! CLICK […]
WATCH: Meghan Trainor Cover 'Shake It Off'
Meghan Trainer covering Taylor Swift?
Kim Kardashian Strips Down In New GQ
Kim K is known for a few things, with her rear end being the most notable. It's safe to say that Kim is well aware of this, and she showed it off in the upcoming […]
News Flash Pamela Anderson Is Still Beautiful
I've always thought Pamela Anderson was pretty…but this new look…stunning.


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About Analog Thinking in a Digital Society
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Analog Thinking in a Digital Society
Alternative thinking, to the popular digital society
Ingredients for an online lecture: my Udacity teaching experience
I've never lectured with a bell before. You see it in the middle of the picture above, just to the right of my hand.
John Owens
Dec 18, 2012
5 min read
The abundance of slowness
Learning to value smart work over hard work requires a paradigm shift, but pays dividends.
Matt Steel
Dec 13, 2012
9 min read
Tablet rasa
To create optimum iPad reading experiences, we need to take Apple's advice from 1997 and think different(ly).
Matt Steel
Dec 13, 2012
8 min read


text: Rudi Kistler and Maurus Oehmann, Mannheim 2012 Courtesy of Francois Brunelle hide caption itoggle caption Courtesy of Francois Brunelle Saw It On The Radio Have We Met Before? Doppelgangers Caught On Camera January 29, 2013 For the past several years, Francois Brunelle has been photographing people who happen to look strikingly similar but aren't related. Listen Loading… 4:37 Download Playlist


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An old drug for diarrhoea is being trialled in people with Alzheimer's and there's a possible stream of new medication to treat the disease.
This is a treatment for neurological disorders like Parkinson's Disease, whereby a small electrode is implanted in the brain.
Dr. Ronald Lazar from Columbia University in New York is gaining insight into brain repair from a potentially devastating problem in the brain called AVM or arteriovenous malformation.
A huge global study coordinates by a group at the University of Sydney has results which fundamentally question doctors' definitions of high blood pressure.
According to studies by Dr. John Mann of Columbia University in New York, suicide is linked to altered brain chemistry.
It's important to separate fact from fiction when it comes to treatments that work for heroin addiction. A national trial in Australia evaluated three forms of treatment for heroin dependence. Associate Professor Richard Mattick from the National Drug and Alcohol Research Centre in Sydney talks about this heroin study and Professor Mary Jeanne Kreek from Rockefeller University in New York, believes that most forms of drug addiction are chronic diseases requiring life long medication.
Researchers in Canada have worked out a technique that GPs and baby health clinics can use to screen babies for cerebral palsy who can then be referred for more detailed assessment and interventions.
A study in Canada found that the survival time after the onset of dementia is much shorter than previously estimated.
Researchers at Beth Israel Deaconess Medical Center in Boston say that the right side of the brain helps people recognize themselves in a mirror or picture.
A relatively simple blood test for diagnosing schizophrenia has been proposed by researchers at the Weizmann Institute of Science in Israel.
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Customer Reviews for
Masters of American Music: The Story of Jazz
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Posted October 1, 2010
An excellent history film
If you found Ken Burns' PBS epic called Jazz to be too long and detailed, this DVD is a perfect short version. It's 100 minutes long, with lots of amazing film from the first half of the century- dancers, a New Orleans parade, and I like the drumset made of cans nailed to the top of a wooden box to which a pedal is attached. There aren't any complete songs, but it has lots of 30-second clips of music. A couple dozen people give commentary about the music and musicians. The sound and picture quality are very good. This is great for people who are just discovering jazz.Was this review helpful? Yes NoThank you for your feedback. Report this reviewThank you, this review has been flagged.
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Coffee Roasters
February 12 Webinar: 7 Steps to Opening a Successful Coffee Shop
Thinking about opening a coffee shop? Then you won't want to miss our Seven Steps to Success webinar on Thursday, Feb. 12 at 2 p.m. EST/11 a.m. PST. In this webinar, Crimson Cup will reveal the Seven Steps to long-term … Read More
Greg Warms up Good Day Columbus with Irish Coffee
Greg stopped by the Good Day Columbus set this morning to help anchors Alyssa Henry and Shawn Ireland prepare for National Irish Coffee Day, celebrated Sunday, Jan. 25. As Greg explained, he first experienced Irish Coffee at San Francisco's Buena … Read More
12 Coffee Houses in 8 States Joined the Crimson Cup Community in 2014
2014 was a great year for independent coffee houses! We were excited to see steady growth in the number of entrepreneurs interested in learning how to open their own independent coffee business. We welcomed 12 new coffee houses in 8 … Read More
UTZ-Certified Fazenda Bela Vista Joins Our Friend2Farmer® Line of Sustainably Sourced Coffees
We're excited to announce the addition of Fazenda Bela Vista to our Friend2Farmer® line of direct-trade coffees. This UTZ-Certified coffee farm in Brazil's Minas Gerais region produces some of the highest quality coffee in the country's highlands. We continue to … Read More
Brandon Demonstrates Hopped Holiday Nitro on Good Day Columbus
The Columbus coffee community has been buzzing about our Hopped Nitro coffees! Good Day Columbus asked Coffee Specialist Brandon Bir to demonstrate the new Hopped Holiday Nitro, which is available through the end of the year exclusively at Crimson Cup … Read More
The Power of the Cup® in Opening a Coffee Shop
Thinking about opening a coffee shop? Consider putting the Power of the Cup® behind you. With the Power of the Cup®, you can learn everything you need to run a profitable – and enjoyable – independent coffee business. What's the … Read More
New Single-Serve "Grounds for Hope" Coffee to Benefit Cancer Support Community Central Ohio
Central Ohioans now have even more options for supporting a great cause while sipping their morning java. We've added single-serve coffee capsules to the line of "Grounds for Hope" coffee we roast for Cancer Support Community Central Ohio. We've also … Read More


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Description10 Key Rollover in gaming modeActuate as many keys as you have fingers, and have all of them register accurately and quickly in game. With the Razer DeathStalker Ultimate's anti-ghosting capabilities, you can deliver overwhelming destruction to your opponents, and ensure that every command is registered and executed perfectly.Razer Synapse 2.0Razer Synapse 2.0 is cutting-edge, intuitive software that functions as the Razer DeathStalker Ultimate's brain, automatically syncing the gaming keyboard to a cloud server to download driver and firmware updates, while saving your individual settings. Sync your custom settings and macros automatically with this unified configurator, allowing customization of all your Razer products with a single login.
Product Details
|Item #
|Manufacturer #
|brand name
|connector type
|Device Supported
|Hot Keys
|Programmable; Macro
|Keyboard/Keypad Connectivity Technology
|Keyboard/Keypad Features
|Integrated Backlighting; Wrist Rest; LCD Touch Panel
|Razer USA Ltd
|operating system compatibility
|USB port; Internet Connection (for Driver Installation); At Least 75MB of Hard Disk SpaceOperating Systems:; Windows 7; Windows Vista; Windows XP
|Pointing Device Type
|Product Line
|DeathStalker Ultimate
|Product Name
|DeathStalker Ultimate
|Product Type
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Spaces and rooms
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Sleeping Porch... or bedroom
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oh my goodness. my dream bedroom.
guest house.
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framed maps of places you love. Now behind my search for vintage maps!
cool decoration idea- framed maps of places you love
map wall. add those vintage maps too. Zach and I have inherited so many cool old maps that we could do so much with!
framed maps of places you love or places you've been - makes an awesome gallery wall!
framed maps of places you love-doing this in our new house!
framed maps of places you love or places you've been - love this for the dining room
Map wall. Frame maps of places you've been or places you dream of going!
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Pallet bed frame idea
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Dream bed!
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perfectly simple black & white bathroom, black showerhead and taps
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