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Drug Discovery
Lab Technologies
Complete Response Rates Seen in Refractory Melanoma Patients
By BiotechDaily International staff writers
Posted on 04 Jun 2014
New research examines complete response and induced immune response in melanoma patients that may generate a "bystander effect."
Provectus Biopharmaceuticals, Inc. (Knoxville, TN, USA), a development-stage oncology and dermatology biopharmaceutical company, reported that data on its investigational agent PV-10 for intralesional (IL) treatment of locally advanced cutaneous melanoma was featured in two presentations, on June 2, 2014, during the American Society of Clinical Oncology (ASCO) annual meeting held in Chicago (IL USA). These presentations show that IL PV-10 can potentially offer cancer patients control of their cutaneous symptoms and provoke a systemic antitumor immune response that may lead to response of uninjected lesions (the "bystander effect" that has been observed in earlier clinical studies of PV-10).
The first highlighted poster, presented by Sanjiv S. Agarwala, MD, of the St. Luke's Cancer Center (Bethlehem, PA, USA), was entitled "Efficacy of intralesional rose bengal in patients receiving injection in all existing melanoma in phase II study PV-10-MM-02." The second highlighted poster, presented by Amod Sarnaik, MD, from Moffitt Cancer Center (Tampa, FL, USA) was titled "Assessment of immune and clinical efficacy after intralesional PV-10 in injected and uninjected metastatic melanoma lesions."
Dr. Agarwala and coauthors from seven prominent melanoma centers in the United States and Australia studied the safety and efficacy of IL PV-10 in an 80-patient international, multicenter, single arm phase 2 trial. A subgroup analysis of 28 patients with all existing melanoma lesions injected and an additional 26 patients with only one to two uninjected bystander lesions showed that these patients experienced an exceptionally high rate of response. The best overall response rate (BORR) in the 28-patient "all treated" subgroup was 71% (confidence interval (CI) of 51%–87%), with 50% complete response (CI 31%–69%). Among the 54 patients in both of these subgroups (i.e., patients who had all of their disease monitored in the study), complete response (CR) was achieved in 232 of 363 injected lesions (64% CR). Furthermore, CR was achieved in 121 lesions after a single injection of PV-10; 84 lesions required two injections to achieve CR; 22 lesions required three injections; and five lesions required all four allowed four injections.
Dr. Agarwala said, "The high rate of symptom control in refractory patients with disease limited to the skin, manifested in CR of all monitored disease after minimal intervention, is the basis for a pending breakthrough therapy designation application for PV-10. Although the primary ablative effect is responsible for CR in injected lesions, durability of response and bystander response observed in this study implicate an immunologic mechanism of action secondary to ablation."
In the Moffitt poster, Dr. Sarnaik and coauthors reported interim results of a pilot clinical trial designed to investigate the immunologic basis of this bystander response. In this single institution translational study, a target lesion and a bystander were biopsied prior to treatment of the target lesion with PV-10. Both lesions were then resected within 7-14 days of target lesion injection and compared to pre-treatment biopsies. Peripheral blood was also collected pretreatment, at the time of resection, and at day 28. The researchers note "treatment with IL PV-10 led to pCR (pathologic complete response) in the post-treatment biopsies of both PV-10 injected and uninjected study lesions in four of the eight patients, and all eight exhibited at least partial regression of the injected lesion." The abstract continues, "Six of the eight patients had metastatic disease refractory to previous ipilimumab, anti-PD-1 and/or vemurafenib therapy." Based on T cells isolated from the peripheral blood of the patients, the authors conclude that, "IL PV-10 treatment can lead to systemic antimelanoma immunity and pCR in injected and uninjected lesions including treatment-refractory tumors."
Craig Dees, PhD, CEO of Provectus, said, "Taken together, these posters indicate that, with minimal intervention, PV-10 can rapidly eliminate refractory cutaneous melanoma lesions. IL PV-10 is also associated with an increase in important circulating immune cells specific to the injected lesion, potentially explaining the high rate of bystander lesion regression seen in our clinical trials of PV-10 in locally advanced melanoma patients. The duration of response and the bystander response reported in the phase 2 trial was beyond the scope of simple tumor ablation. In 2013, Moffitt researchers published data from mice showing increased antitumor T cell responses, and this year at ASCO they have bridged that nonclinical finding to the same phenomenon in man. It is unprecedented for a small molecule ablative agent to have this kind of immune system activity detectable in peripheral blood of patients. The one-two punch from PV-10 [rapidly reducing tumor burden and producing immune system stimulation] is presumably the underlying driver of these durable complete responses in patients with cutaneous melanoma."
Provectus submitted an application in March 2014 to the US Food and Drug Administration (FDA) for breakthrough therapy designation for PV-10 based on the results from its phase 2 clinical study related to metastatic melanoma and is researching efficacy of PV-10 for other indications, including liver and breast cancers.
Provectus Biopharmaceuticals specializes in developing oncology and dermatology therapies. Its novel oncology drug PV-10, (a formulation of the small molecule ablative agent rose bengal disodium) is designed to selectively target and destroy cancer cells without harming surrounding healthy tissue, significantly reducing potential for systemic side effects. Its oncology focus is on melanoma, breast cancer and cancers of the liver. The company has received orphan drug designations from the FDA for its melanoma and hepatocellular carcinoma indications. Its dermatological drug PH-10 also targets abnormal or diseased cells, with the current focus on psoriasis and atopic dermatitis. Provectus has recently completed phase 2 trials of PV-10 as a therapy for metastatic melanoma, and of PH-10 as a topical treatment for atopic dermatitis and psoriasis.
Provectus Biopharmaceuticals
St. Luke's Cancer Center
Moffitt Cancer Center
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text:
Aqua Man's Pool
I'll post more once we plant our trees and plants.
We are FINALLY DONE with the landscaping (except for 2 trees).
A Pom-Pon juniper tree will go against this fence.
A Hinoki Cypress tree will go behind the waterfall.
We still need to get a bridge to go over the rocks and connect to the walkway on the side of the house.
We also painted our house :-)
Next year my outdoor bbq island will go where the table is and we will get all new patio furniture :-)
What kind of plants/trees did you put behind the pool, near the fence? Your landscaping looks to be evergreen, which is what our yard is. I am looking for ideas to replace some of the landscaping we had to pull out that will also run along our fence. There will be a small planter area between the RBB and the fence - maybe 4 ft. and will run the length of the pool for the most part.

subset: commoncrawl


text:
Mark The World
Credits & Info
- Date
- 08/19/2010
- File Info
- Song
- 3 min 38 sec
- Score
- 4.26 / 5.00
Related Content
You might also enjoy:
Licensing Terms
- Attribution:
- You must give credit to the artist.
- Noncommercial:
- You may not use this work for commercial purposes unless you make specific arrangements with the artist.
- Share Alike:
- If you alter, transform, or build upon this image, you may distribute the resulting creation only under a license identical to this one.
- Score:
- Rated 4.26 / 5 stars
- Plays & Downloads:
- 2,763 Plays | 191 Downloads
- Share Links:
- Genres:
- Electronic - Ambient
- None
Author Comments
Rated 4 / 5 stars
I can almost see the man upon the rock. Also quite a Piece even with only so many keys.
They can never say good music cannot be achieved though a Mac!!
Keep up the good work. :)
Rated 5 / 5 stars
Very good!
What I like about this piece is it's rich imaginery and calmness. I can easily relax to this and let my thoughts fly away like in a dream. I like your story with all the metaphors aswell, maybe you are the only one who knows what they mean.
Keep it up.
I think im the only one who knows what my songs REALLY mean lol, but hey im fine with people interrupting them themselves! :)
Rated 5 / 5 stars
so calming... MAKE MOAR
Troll ololol? Lol. xD
I hoep to make moar!
Rated 4.5 / 5 stars
sounds like
it could be in tower of heaven 2 or something
If there was a tower of heaven 2, I would be proud to have my song in it :)
Rated 5 / 5 stars
I read the story out loud at barely above a whisper, more of a murmur. The sound of my soft gravely voice pieced with the passionate beauty that you've provided made for a story that gave me shivers.
You've come a long way, my friend, keep up the good work.
Haha, thanks man. I have really focused on the imagery / symbolism inside of my tunes in the past few months. I am writing some experimental things right now that don't have any actual rhythm, unlike this song, but fully focus on imagery and fantasy. Once I have a clear understanding of creating that sort of music, I will expand on it and create another ambient song that is like this, but a lot more complex. Glad to see you back on NG.


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You can now invite anyone to meet at your favorite Starbucks.
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38 year old man | Raleigh, NC, USA | Seeking women 18-35 within 50 miles
Hey good ppl out there drop me a line
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Basketball, Bowling
I exercise 3-4 times per week.
I like Dogs
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I'm considering upgrading the 2007 Boxxer Team on my Sunday. Is this a good deal & smart choice? The Team has never really done me wrong, however it is getting beaten up, leaks a bit and is a bit heavier than the WC. What do you think?
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Record Editorial: Try not to think about it, but it's severe weather awareness week
Winter is finally gone, but before you get too carried away celebrating that last patch of snow melting away in the back yard, we have to tell you this is severe weather awareness week.
That's right, life in Minnesota is not all blizzards and deadly wind chills -- you also have to watch out for tornados, hail, straight-line winds, flash floods, heat waves, and lightning. Not necessarily in that order.
Feeling good about life? Consider this:
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You will need your subscription account number and phone number. Not sure if you have an account? Email us at email@example.com and we can help you.


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Friday, February 20, 2015
Somebody's Party
Learning to enjoy your own company can be difficult. Being in your own company can be complete torture sometimes; your thoughts can wander and race and you can't get control of your mind. People can cause so many unnecessary problems for themselves by trying to escape themselves and their thoughts. Some will even drink excessively or turn to drugs in order to silence a voice in their mind that won't shut up. We all have it to some degree. It's that voice that tells you you're not good enough. Some people rarely hear it, others hear it after any tiny mistake they make, and some can rarely find moments where they are free from it.
Learning to accept and forgive yourself is so simple and yet so difficult. You have to accept that you are not perfect and never will be, but also make a conscious effort to improve that which you don't like about yourself. Stop hating yourself for all that you have done wrong; understand that everyone makes mistakes. Be your own best friend; learn to be kind to yourself by regulating your thoughts and emotions. When you find your mind spiraling in the wrong direction find a way to feel appreciation for something, no matter how big or small. Find a way to focus on that feeling for as long as possible and carry that with you as long as you can throughout your day.
Photos by my amazing friend Wendie Cusator <3
Follow her @cusatorphotography
Friday, February 13, 2015
The concept of freedom is something that has frustrated me a lot these past few years. Who has it? Does anyone have it? Do we all have it? How do I get it? Am I really free to do and be whatever I want and if not how do I attain that freedom? I find that feelings of restriction, confinement, and helplessness are almost always at the root of unhappiness. To me, freedom is the equivalent of happiness. Freedom is empowerment in its highest form. The freedom to be what you want, to do what you want, to say what you want, and just be are often thought of as having to be earned or given but in actuality it is yours to take at any moment.
The quickest way to find freedom is to silence everything around you. Find a way to be one with the present moment. Don't worry about tomorrow, the next minute or second; focus on where you are right now, where you have been and where you are going. Feel appreciation for how far you have come, how much your life has progressed and how the beautiful journey ahead will allow you to grow that much more. In this moment you might feel your heart swell and get light and fluttery. Your mind will clear completely and your eyes may even begin to water from relief. You should feel proud, humble and an overwhelming sense of hopefulness and gratitude. This is how I find freedom within myself and it empowers me to find and search for the freedom in all other aspects of my life.
Please understand that whatever your current situation is and however powerless you feel to the circumstances of your life, you have complete power and freedom to not be controlled by it. You are free as long as you choose to be.
Photography by my lovely friend Linda
Check her out and follow her @nn_linda
Friday, February 6, 2015
Finding Your Focus
Losing your focus can be just what you need sometimes. It's like doing a really difficult math problem and spending hours trying to solve it. You try to calculate this way, then another, then another way, then backtrack and reverse and are finally left with nothing to do but stare blankly at the frustrating assortment of numbers in defeat hoping some act of god will occur and strike you with the answer. In times like that, it's always good to take a breath. Take a short break and recuperate. Get distracted, let your mind wander and work on something else. Find a way to relieve the pent up stress and then promptly come back. Most times you will be able to see a new perspective and way of solving the problem.
Finding the answer may mean having to lose your focus for a brief moment. Finding the next step to take may mean having to walk away from the problem and then coming back to it. Take some time to be a little irresponsible and careless, but don't neglect your goals completely or for too long. Don't give up and don't lose sight of what you want. Relax, readjust, refocus on what you want and then keep going.
Photography by my lovely friend Linda
Check her out and follow her @nn_linda
Posted by Styled By Noosh at 4:48 PM 8 comments:
Labels: OOTD, Outfit Post
Friday, January 30, 2015
Spoiled Rotten
I firmly believe in spoiling yourself, not out of vanity but out of self love. Spoil yourself with nice things, great company, love, delicious food, and spare time to do with as you please. Spoil yourself by setting your standards high and making the most of your time by doing things that enrich your spirits. Listen to music that makes you feel light-hearted, catch up with old friends, and take a long walk for the hell of it. Spoil yourself with the thoughts that you think. Stop over analyzing situations and being so critical of yourself. Believe that the world is on your side and kill any negativity that approaches you with kindness.
Top - Liz Claiborne, thrifted from Black and Brown, San Jose CA
Jeans, Shoes and Watch - Michael by Michael Kors
Purse - Dior
Gold Necklaces - hand me downs from my grandma <3
Photography by my lovely friend Linda
Check her out and follow her @nn_linda
Friday, January 23, 2015
Playing Games
Life is a game; a non-competitive game of Sorry! to be exact. It's really colorful and fun, it's not meant to be taken too seriously, but every now and then you have to make some sporadic moves and laugh like a super villain as you knock some pegs off the board. My end goal is always in sight, but maneuvering my way to get there takes countless readjustments to the game plan. It's literally all a game.
It's all just this crazy juggling act and one small slip up can make it feel like everything is crashing down. My focus is constantly changing each and every day. The game plan is constantly changing and readjusting to whatever the current situation brings. Flexibility is a virtue many forget to mention or even consider, yet without it you won't find yourself going very far. Like I have said before, things almost never go to plan but that doesn't mean they don't have a way of working out. You have to continuously scan and analyze your surroundings. What can you make from this? What do I do now? How do I take the next step forward? If you keep searching you will eventually find exactly what you need.
Vintage Halston Sweater and Lee jeans - thrifted from Black and Brown San Jose, CA
Steve Madden Sunglasses - Marshall's
Flats - Luxury Rebel
Rose Gold Bradshaw Watch - Michael Kors
Photos by my lovely and talented friend Linda :)
Check her out and follow her @nn_linda
Friday, January 16, 2015
I have such a love for places like Chinatown in San Francisco. The energy and life is abundant and inescapable. There are a million different stories waiting to be told at any given moment. I remember walking by this park and there were dozens of different groups of people gambling and playing card games. I had never seen anything like that before. It was so strange to have that realization, that something as insignificant as a lot of different people doing nothing other than just hanging out at a park and interacting with each other was unusual. Why is that such a unique sight to see? Why did this image stand out more than anything else that day? People don't hang out anymore. Everyone is so isolated from one another to the point where something like a community of people who hang out together is something almost unheard of.
Bangle set from Original Cowgirl Clothing. Follow on Instagram @originalcowgirlclothing
Booties - Michael by Michael Kors
Waxed Jeans - H&M
Cardigan and Turtleneck sweater - thrifted
Photos by Phillip Santos
Follow him @ps_toast
See more of his work at http://www.flickr.com/photos/phillipsantosphotography/
Friday, January 9, 2015
Beautiful Disasters
I am a firm believer in the idea of life is what you make it. Sometimes life will throw a really shitty hand of cards your way but what many fail to understand is that the shittiest hand can quickly become the best. Transform and transcend everything to make it what you want. Life rarely works out the way you want it to, but if you can move forward and take all that you can from every negative and positive experience you never lose. Let every perceived misfortune propel you that much further into the direction you want to go.
"Energy cannot be created or destroyed; it can only be changed from one form to another. "
- Albert Einstein
It's all about perception. Life is whatever you perceive it to be. I don't lose and I can't lose because I don't see it as an option. No matter what happens I am able to make the best of it.
photos by Matt Martin
follow @mainymatt
Posted by Styled By Noosh at 1:00 PM 10 comments:
Labels: Outfit Post, Style Blog, Vintage
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pine cone ginger
I purchased some pine cone ginger. I never tried to grow a ginger before. I planted some of them outside and I kept a couple and planted inside. I have them for a month now and there is nothing growing above the dirt yet. How long do they take to grow?? I was so thrilled how beautiful this ginger was and now I am so disappointed its not growing.
They are just about to sprout in zone 8, and you are in zone 6. It will probably be much longer before they sprout for you. Soil temperature stimulates breaking dormancy. Dormant gingers are generally the very last perennials to sprout, even in warmer zones. You would probably have better look trying to grow some in a large pot that can be stored dry indoors somewhere. they won't survive outside, and if you break up the rhizomes too much while digging them to store indoors, they'll probably never get mature enough to bloom. there are some dwarf varities that are easier to deal with though.
tim chapman
I'm just down the road from Tim and my pinecones just stared putting up shoots this weekend in a bed that gets full sun until midafternoon. The ones in a bed that gets only partial sun until midafternoon followed by shade haven't warmed up enough, yet.
As I mentioned in another post, I think people are often surprised at the very slow response of some tropical plants to warmer weather and better growing conditions, when the plants are trying to break dormancy, and it often take s good month of "sustained " warm soil conditions for them to finally break their dormancy. After that the same thing is true for the topgrowth as well, so if you don't have summers with constant warm days and nights, the topgrowth can be exceedingly slow, and you're unlikely to see flowering before it's time to return the plants back to the indoors for the fall. I say for the "fall" since indeed if you want them to succeed you may want to grow them yearound and not encourage dormancy for some varieties. If you leave them outdoors late into the fall and subject them to cool tmeperatures , they may indeed go dormant for the rest of their winter storage period. Not all benefit from an "unatural" imposed dormant period, and they may fail to perform in the future.


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Dr. Jason R. Fought, MD
Internal Medicine
- 3200 W Slaughter Ln
Austin, TX 78748
- 2 Locations
- (512) 282-0141
Dr. Jason R. Fought graduated from the Texas Tech University Health Science Center School of Medicine - Lubbock in 2001. He works in Austin, TX and 1 other location and specializes in Internal Medicine. Dr. Fought is affiliated with North Austin Medical Center, Saint Davids Medical Center and Saint Davids South Austin Medical Center. He speaks English and Spanish.
Gender: Male
Languages Spoken: English, Spanish
Internal Medicine
Medical School: Texas Tech University Health Science Center School of Medicine - Lubbock; Graduated 2001
*This physician has multiple office locations. See Office Information for details.


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Botha set for Toulon switch?
ESPNscrum Staff
February 21, 2011
Botha has reportedly put pen to paper on a three-year deal with Top 14 club Toulon © Getty Images
Springboks lock Bakkies Botha has reportedly agreed a move to big-spending French club Toulon.
According to Midi Olympique, the 31-year-old Bulls second row has put pen to paper on a three-year contract that will see him link up with the big-spending Top 14 club after this year's World Cup. The deal is worth a reported 700,000 euros (£589,000) a year and is set to be confirmed by Toulon owner Mourad Boudjellal in the next 24 hours although the club website appeared to verify the reports earlier today.
Should the move be confirmed, the Rugby World Cup winner will become the latest in a long line of international stars to be lured to the south of France. Botha's long-time second row partner Victor Matfield is among those to have graced the Stade Mayol along with All Blacks centre Sonny Bill Williams.
More recently Wales international Gavin Henson made the switch to play alongside the likes of England fly-half Jonny Wilkinson, former All Black Carl Hayman and ex-Wallabies flanker George Smith. And current Wallabies star Matt Giteau was the most recent to commit his future to the club having confirmed his intention to move to France after the World Cup.
Botha, who helped the Bulls open their Super Rugby account with a win against the Lions at the weekend, was previously targeted by Toulon in 2009 but the French club were thwarted due to his existing with contract his Pretoria-based side. Capped 72 times by South Africa, Botha has also won two Currie Cups with the Blue Bulls (2002 and 2009) and three Super Rugby titles with the Bulls (2007, 2009, 2010).
Asked for comment, Bulls High Performance manager Ian Schwartz told SuperSport.com, "Bakkies is a loyal Bull player and has always played open cards with us. He has always maintained that at the end of the 2011 season he wanted to continue his career overseas and we wish him well. We know that he will continue to give his all and remain a loyal and committed player for the Bulls and Springboks until the end of the year."
Sale prop Eifion Lewis-Roberts is also in line for a move to the continent with the Welsh international reportedly on the brink of a high-profile move in a two-year deal.
© ESPN Sports Media Ltd.
|Live Scores
Jones key to Wales World Cup plans
Huw Richards assesses where Wales are after a mixed Six Nations, with front row seats still very much available for the World Cup
Attacking revolution will be fleeting
John Mitchell lapped up the action on 'Sensational Saturday' - but warns not to expect a repeat come Rugby World Cup time later this year
Ireland, England are dangers if ...
Craig Dowd warns England, Ireland and Wales they should play to their strengths rather than those of the All Blacks and the Wallabies
Six Nations prospects for the World Cup
Tom Hamilton runs the rule over just where the six countries stand ahead of the global gathering in September


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Housewives On Trial In China For Smuggling In iPhones 150
from the random-headline-generator dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
Ah, roast scapegoat...
Talk about clickbait headlines... tfa says it's an $80,000,000 smuggling ring that's been busted...
This isn't some little old ladies smuggling a few iPhones in their suitcase for the price of a meal...
Seriously I can't help feeling like Apple propaganda is kind of sad now they are irrelevant. The iPhone is a failure in China and in current news its market share [as everywhere] is dropping YOY [its irrelevant] from 5.8% and by quarter from 6.0 down to 4.2 unlike Android which has gone YOY 46.8% and by quarter 82.8% to 90.1%...Android is outselling Apple 21:1
Aren't the facts rather that yes, Android is on most cheaper smartphones, hence they sell a lot in total, but Apple still has a good grip (and profitability) on the high end market.
I think you can compare Apple to a car manufacturer like BMW. Generally well designed and made, often pointing the way forward, indeed relatively small compared to a mass maker like Toyota yet financially healthy.
The iPhone is a failure in China and in current news its market share [as everywhere] is dropping YOY [its irrelevant
A lot of things are failures in China. Google is a failure in China. Facebook is a failure in China. Does this mean google and Facebook are irrelevant too? If you did world wide market share of social media or search engines I bet you'd discover that whatever is popular in China ends up having the most market share because china has almost 5x more people than the US
"Mr. Watson, come here, I want you." -- Alexander Graham Bell


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Fireside Inn & Suites
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- Continental Breakfast
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Home Sweet Home
Snow yesterday. No surprise, it's January in New Hampshire. So it's a lazy day today. I am trying out this Travel blog that my friend Elaine uses. That'll pass a few hours before the Pats AFC championship game against the Broncos ( I almost said Colts, forgetting Peyton is with a new team). Go Pats. I am supposed to go to the Armenian museum later this morning with my NRG book club; depends on the weather. It's just us girls going. Steve is not a museum ...
June is for weddings
... turkey breast and invited Doris to join us. Good time talking with her. She is absorbed by her brother in CA that is dying and they are trying to get him back here and into a nursing home. After she left we talked till late and then resumed our reading of our Steinbeck book, Grapes of Wrath. I showed Phil the pillowcases that I had made for wedding gift and he liked them. Oh, I was brushing my teeth tonight, and one of the two new crowns came off!!!!! Glad it is ...
Snowy Boston to sunny Mesa
... we could not find the address and eventually did, then the door was locked and appeared no one was there (it is an office space) and finally he signaled to the driver that he was be right out. And we waited and waited and waited, and finally saw some movement inside. Eventually he came out, and back in and out and back in and finally to the car. Never said a word to anyone, but took a lot of time and left the other passenger with 35 minutes to check in, do security and get to ...
More adventures in Boston
... that didn't agree with me so feeling a bit down tonight.
Sept 18th-Tuesday-Up early and I feel fine. We walked down the hall to breakfast – they have a good one here – and after that back to sit out on our patio and enjoy the morning for a bit. Next showers and out to do some exploring. We drove north to the museum near the Kettleholes and spent a long time there including 2 short movies. Then drive around and ended up ...
Learning more of the Boston area each time
... breakfast read the paper before leaving on our journey. A stop at the bank and at CVS and we are heading to the Mass Pike for the town of Lee almost to the western border of MA. It is only about 2 � hour drive from one side of MA to the other! This is heavily wooded area all the way – you cannot see anything but trees. Traffic was stop and go so it took us 3 hours to arrive at our America's Best Motel. Took our bags in and headed for the Norman Rockwell ...


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"Daydreaming Tomorrow" Art Print by Justin Santora
Wow, this new art print by Justin Santora is just beautiful. "Daydreaming Tomorrow" is a 19″ x 25″ screenprint, has a tiny edition of 33, and is $30 shipped. As with all of Justin's stuff, this is hand-drawn, separated, and printed. Pick one up in the Gigposters.com Classifieds.


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Bioshock Infinite: The Handyman
Like the Motorized Patriot, the Handyman is one of the sub-bosses that you will encounter in Bioshock: Infinite. Handymen can pick up NPCs – including your enemies – and then lob them at you.
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Quote of the Week
"Three Rules of Work: Out of clutter find simplicity; From discord find harmony; In the middle of difficulty lies opportunity."
– Albert Einstein
A New Year
From a hike up North Mountain, December 2014
"May your trails be crooked, winding, lonesome, dangerous, leading to the most amazing view. May your mountain rise into and above the clouds." -Edward Abbey
I have been racking my brain to write something out of all the retrospectives I have read at the end of the year, to start a new one. To write something that will sort of rally the troops as we all delve into this year together.
I came up short of anything thought-provoking, but thinking about it did make me write about some other stuff.
Most years start off easy, take everything at a relaxing pace, and most years end the same way. I have decided that for this year, I'm going to go hard into the paint, so to speak.
(Also, "hard into the paint" is my favorite, and only correctly used, sports metaphor, so please let me have it and don't judge me for using it too often.)
Sure, I might burn myself out. But I haven't felt that great burned out from being creative burn in a while. Having that feeling under my belt might open me up to even more adventures.
I love the idea of thinking about projects and experiments, rather than resolutions. I can resolve to send out inspirational postcards to pen pals once a month, if I think of it more as a happiness project. I can also experiment with a new habit if I think of it in terms of just one month, like Art of Manliness' 31-Day Journal prompts. I also might possibly need a little help in re-learning how to pay attention.
A little late, but some things to think about for the coming year in these New Year's Asks.
Quote of the Week
"I've known women who plodded through life…but the women I knew did their plodding on the pavement, not the soil. I know very little about the simple life. I'm a product of crowded places and jammed-up emotions, where right and wrong weren't always clearly defined and life wasn't always sweet, but it was life." —Barbara Stanwyck
I thought I would formally welcome you to the last couple weeks of Noirvember with a quote from one of my favorite noir ladies, Barbara Stanwyck. For the same reason I love bitter chocolate and black coffee and stale cigarette smoke alleyways, I love film noir.
I kicked off the month watching The File on Thelma Jordan, starring the above femme fatale. I have made it few only a few new ones (Night in the City, You Only Live Once), and several old ones (Detour, Kansa City Confidential), before this month got a little busy. But I like to carry noir with me all year long, so I make no qualms about Noir Christmas/New Years, et al.
Quote of the Week
"You listen to me. While I will admit to a certain cynicism, the fact is that I am a naysayer and hatchet-man in the fight against violence. I pride myself in taking a punch and I'll gladly take another because I choose to live my life in the company of Gandhi and King. My concerns are global. I reject absolutely: revenge, aggression and retaliation. The foundation of such a method… is love. I love you Sheriff Truman."
I am not-so-patiently waiting for the temperature to drop. While it is cool in the morning, it doesn't feel quite cool enough to through on my beloved Twin Peaks this time of year. Maybe by putting this quote out into the world, I can manifest some weather suitable for putting on my flannel, pulling the fish out of the percolator and wishing I lived in a cabin near Snoqualmie Falls.
Swayztember Dancing
Happy Swayztember!
I will be celebrating by watching some of my favorites, and seeing if I have overlooked any of The Great Swayze's film library.
I fully love this. Not only is this gif great, but it goes with so many great songs. I have watched it while listening to:
♠ and of course, Party Up (Up in Here)


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- Incomes Rise, Consumer Spending Ticks Slightly Higher In FebruaryPosted 12 hours ago
- Prehistoric 'Super Salamander' DiscoveredPosted 17 hours ago
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- VIRAL VIDEOS: Watch Ryan Gosling Dancing As A Kid!Posted 3 weeks ago
- Jeb Bush To "Actively Explore The Possibility Of Running For President"Posted 3 months ago
- Insurance Industry Giving Affordable Care Act Customers More Time To Pay PremiumsPosted 3 months ago
- Boehner Responds To President Obama's Immigration Plan [VIDEO]Posted 4 months ago
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- FOX in the Fast Lane: Kicking Off The ChasePosted 7 months ago
- Obamacare Data Discrepancies Could Jeopardize CoveragePosted 9 months ago
Two Leaders Allegedly Behind Christmas Airline Plot Released From Gitmo In 2007
According to US officials and Department of Defense documents, two of the four al Qaeda members behind the plot to blow up Northwest 253 were released from the Guantanamo prison in November 2007.
American officials agreed to send the two terrorists from Guantanamo to Saudi Arabia where they entered into an "art therapy rehabilitation program" and were set free, according to U.S. and Saudi officials.
Guantanamo prisoner #333, Muhamad Attik al-Harbi, and prisoner #372, Said Ali Shari, were sent to Saudi Arabia on Nov. 9, 2007, according to the Defense Department log of detainees who were released from American custody. Al-Harbi has since changed his name to Muhamad al-Awfi.
Both of the former Guantanamo detainees are described as military commanders and appear on a January, 2009 video along with the man described as the top leader of al Qaeda in Yemen, Abu Basir Naser al-Wahishi, formerly Osama bin Laden's personal secretary.
Al Qaeda in the Arabian Peninsula issued a statement Monday claiming responsibility for the incident referring to suspect Umar Farouk Abdulmutallab as a "hero" and "martyr."
The two-page written claim included a photo of Abdulmutallab and boasted of Al Qaeda's success in designing "advanced explosive packages" that can pass through airport screening undetected.
The statement also asks for attacks upon Americans in the Arabian peninsula, and promises further attacks on the American people.
A US diplomat says, "The so-called rehabilitation programs are a joke," but the Saudis say these programs help return terrorists to meaningful lives.
Subscribe to my premium podcast and get exclusive access to the listener club.


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Today, Miller Electric continues their dominance in the marketplace with machines like the Millermatic 211 and the Dynasty 200 DX, Auto-darkening welding helmets, and the Diversion 180 AC/DC TIG Welder. Miller's full line of welding machines and welding accessories give their loyal customers plenty of reasons to "Bleed Blue."


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Ho, how I love SA revolvers... and yours really takes the cake!
I've always heard that trying to be PC is like trying to pick up a "small sample of feces" from the clean end....
Awesome post. Awesome gun!
Thank you sir, its nice to see your Ruger firearm and looks like its in great shape.
I love Rugers and the revolvers, well, they are built like tanks, reliable, accurate. I have the GP100 for tons of years now and shot about 5000 rounds through it. I hope to someday get up to your rounds count! I know I will certainly have fun trying!
You do understand this thread is 2 3/4 old since the last post?
Those who hammer their guns into plows will plow for those who do not." ~ Thomas Jefferson
ha! I just saw the date on the post before mine and didn;t check any of the earlier ones.
OP probably has a few more thousand rounds on the Ruger by now.


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Long Beach is home to the famous Queen Mary, a ship built in the UK in the 1930's that sailed its way through the Great Depression, World War II, and the 40's and 50's as a transatlantic travel vessel. Since 1967, it has sat off the coast of Long Beach, CA as a hotel and tourist landmark.
The rich history of Queen Mary is best described in her WWII days, when over 16,000 American troops traveled aboard. This is still the standing record for most passengers ever transported on one vessel.
Adolf Hitler once offered a quarter of a million dollars and the Iron Cross to the captain who could sink the Queen Mary. Winston Churchill also sailed aboard the ship, signing the D-Day Declaration during his travel.


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Cutting the cord isn't always a straightforward process. Here's what you need to know.
With Google's mix-and-match Project Ara handsets, the time is ripe for wacky add-ons to truly customize your phone.
The DVR stalwart will rename one of its most iconic features to reflect an upgrade that integrates streaming and broadcast sources into the My Shows menu.
Telecommunications and internet service providers will now be required to store their customers' metadata for at least two years under laws that passed the Australian parliament with little opposition.
Following a landmark UK decision ruling certain mass surveillance practices illegal, a privacy group has simplified the process of demanding to know if your rights were violated.
The Audiophiliac looks back on the long and distinguished career of this New York-based maker of speakers, turntables, headphones and more.
Chief executive Marcelo Claure defends the company's stance as the only major wireless operator to support the FCC's new Net neutrality regulation.
Benedict Cumberbatch is on enigmatic form as the computing pioneer and war hero, but this biopic doesn't quite crack the code.
Quirky combines a surge protector and a portable battery charger into one device, but the pair makes a bad match.
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By Charlene M. Jett
A truly wonderful day for Evergreen Outreach. The presence of the Lord was with us, as many of our FAYCO friends arrived. We shared refreshments and cookies, and caught up on what happened after the extra-long cold winter interfered with our good times. Ugh!
We opened the program by singing "Happy Birthday" to Mary Woolsey, Beulah Brown, Tanya Robinson and Randy Schukar.
Three years ago, I wrote in the Minister's Forum that Temple Baptist Church and First Baptist Church of Vandalia had entered into a discussion about the possibility of merging into one new church.
During a presentation by Vandalia Memories administrator Kathy Schultz at last week's Fayette County Genealogical and HIstorical Society meeting, those present tried to figure out what, if anything, as at Eighth Street and VanTran Avenue (now Veterans Avenue) before Henry's.
Society member Jerry Jones answered the question within a couple of days by providing an old aerial photograph of the area.
Monday afternoon, there was considerable traffic through Vandalia, even after more than 10 inches of snow fell late Sunday and early Monday. The fact that there was less traffic than normal was mostly due to the fact that Presidents' Day was being observed.
Those who wanted to get around Vandalia could do so because the city of Vandalia's public works crew were on the job on their day off.
'Sneaky Pete,' the Wily
Wolf …
…the Homestead wild critter, is back in the neighborhood! After several months of us being concerned that something had happened to him, Sneaky Pete was seen visiting in our across-the-road neighbors' back yard.
Neighbor Debbie Ward called to say she saw him in their backyard sniffing around and then seemed to be chewing on something. She said that she was so stunned at seeing him, that she didn't think to take a picture.
Weekend Visitors
Owen Harpster, 2 ½, and Aaron Harpster, 1, spent the weekend with their grandparents, Dane and Belinda Harpster of St. Peter.
Birthday Party
JoHanna Bergmann of St. Peter held her second birthday party at St. Peter City Hall on Saturday. Those attending were: Lynn, Stacey, Seth, Konrad and Keiffer Bergmann; Gary and Sue Adams; Bobby, Nicki, Taylor and Hunter Scott; Joe, Luke, Kelly Bergmann and Madison; Nick and Pam Bergmann, Brandon and Kaden Wells; and Dane, Belinda, Owen and Aaron Harpster.
Thursday, January 29
• ExxonMobil Annuitants, noon, Vandalia Ponderosa.
• The St. Elmo Ministerial Alliance is asking area churches to celebrate Super Bowl Sunday. Individuals attending church services are asked to take a can (or more) of soup, which will be donated to the St. Elmo Food Pantry.
• Sunday Night Live, grades 7-12 youth group, 6 p.m., First United Methodist Church Fellowship Hall.
• AMP'd, high school youth group, 6:30-8 p.m., St. Elmo Christian Church.
Monday, February 2
Conflicts on meeting dates was a major topic of discussion at the recent meeting of the Effingham Area Tea Party.
In the future, meetings will be held at 6:30 p.m. on the third Monday of each month.
It was noted that the annual report on tea party officers and directors is due soon.
As a result of voting, President Todd Slingerland, Secretary David Schaefer and Treasurer Jane Willenborg were re-elected to new terms.
Directors of record are Patty Russell, Roger Stevens and Wayne Russell.
The 2014 Salvation Army bell-ringing campaign in Fayette County raised more than $14,000.
This was the result of more than 270 hours of volunteers ringing the bells and shoppers donating money at the red kettles placed at Walmart, Rural King and County Market.
The money raised is used excusively in Fayette County to help families who face a financial crisis due to illness, disability, fire, medical emergency or other unforeseen event.
This interdenominational ministry will help more than 450 individuals and families throughout the year.
Dr. Ryan M. Jones has accepted a teaching position at State University of New York in Geneseo.
Jones is teaching Latin American history and is part of a cluster interdisciplinary hiring initiative that includes faculty members intent on working together across departments for research projects and teaching.
Jones is the son of Janice and Jerry Jones of Ramsey, and the grandson of Virda Forbus and Shirley Jones of Vandalia.
Copyright © 2015
The Leader Union is your source for local news, sports, events and information in Vandalia, Il, and the surrounding area.


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Near the Connecticut border, roughly 35 minutes east of Poughkeepsie, is the village of Dove Plains. Driving its Main street, you'll see a pleasant little community, but what you won't see is something rather spectacular - the Stone Church.
About a ten minute hike from Main street is a cleft in a rock that opens up into what feels very much like a sanctuary space. Indeed, legend has it that Sassacus, the Mashantucket Pequot Indian sachem, (like a chief of chiefs), used this as a hiding place to escape capture and execution by the English Army.
The United States is one of the most diverse countries on earth, jam packed full of amazing sights from St. Patrick's cathedral in New York to Mount Hollywood California.The Northeast region is where it all started. Thirteen British colonies fought the American Revolution from here and won their independence in the first successful colonial rebellion in history. Take a look at these rolling hills carpeted with foliage along the Hudson river here, north of New York City.The American south is known for its polite people and slow pace of life. Probably they move slowly because it's so hot. Southerners tend not to trust people from "up north" because they talk too fast. Here's a cemetery in Georgia where you can find graves of soldiers from the Civil War.The West Coast is sort of like another country that exists to make the east coast jealous. California is full of nothing but grizzly old miners digging for gold, a few gangster rappers, and then actors. That is to say, the West Coast functions as the imagination of the US, like a weird little brother who teases everybody then gets famous for making freaky art.The central part of the country is flat farmland all the way over to the Rocky Mountains. Up in the northwest corner you can find creative people in places like Portland and Seattle, along with awesome snowboarding and good beer. Text by Steve Smith.


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Featured, Hot House, Patterson Park, Real Estate & Home
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You must register online! Payment can be made at the via PayPal or a check can be sent to the address provided at the end of registration.
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Dakota United PI team slips at state
The Dakota United Hawks PI adaptive floor hockey team competed at the state tournament March 18 and 19. They had a good season, posting a 9-1-1 record and earning the No. 1 seed going into the tournament, but the competition at state wore them down.
The team started strong with a 10-2 win over Anoka Friday, March 18. Grayson Nicolay, a seventh-grader from Rosemount Middle School, stole the show that game, scoring six goals.


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Help! Travertine Floors and Grout are GROSS!
gaylOctober 12, 2008
Hi, we moved into a condo a couple of years ago - there are travertine tiles throughout the 2400 sq. ft. The tiles aren't so bad, but the grout is disgusting. I have spent hours on my hands and knees with little brushes, to no avail. Also, we have been using a steam mop on the floor, and I think the dirt from that just collects in the grout. So now it is dark grey and terrible looking, mostly in the kitchen. The rest of the house isn't so bad. I recently tried mixing a paste of oxiclean and water and that actually worked in a small area, but I'm concerned about the affect this might have on the tile. Anyone have any solutions to this, so I can finally have a clean-looking kitchen floor? Thanks so much!


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By: BizStream on October 23, 2014 - 6:56am - Add new comment
Kool Smiles, a leading provider of quality dental care in Amarillo, is coordinating Operation Troop Treats to encourage children to bring their Halloween candy to Amarillo Kool Smiles dental office in exchange for a toy.
The candy will then be sent in care packages to U.S. troops serving overseas via Operation Gratitude.
Every child who donates at a Kool Smiles office will receive one toy for every 25 pieces of unopened candy in its original intended packaging. There is a limit of 3 toys per child and toys will be distributed on a first come, first served basis.
By: BizStream on October 22, 2014 - 6:48am - Add new comment
Sprouse Shrader Smith will host the 13th Annual Labor & Employment Law Seminar Series on Nov. 6.
The series is specifically designed to provide human resource education on current topics. This year's presentations will focus on immigration law, updates on healthcare reform, and human resource tool kits.
By: BizStream on October 22, 2014 - 6:01am - Add new comment
J. Pat Hickman, chairman and CEO of Happy State Bank, announced the hiring of David Tarver as commercial loan officer.
Tarver has been hired as vice president and commercial lender in the Canyon market. He is a graduate of Texas Tech University School of Banking and the Management Development Program of Texas Bankers Association.
Additionally, Tarver attended Clarendon Junior College and Tarleton State University. He has 18 years of banking experience with an emphasis on agriculture lending. Tarver serves on the Texas Bankers Association Leadership Council.
By: BizStream on October 21, 2014 - 11:43am - Add new comment
Amarillo and Perryton entrepreneurs were recognized as recipiences of the 10th Annual Aggie 100, awards honoring the fastest-growing Aggie-owned or Aggie-led businesses in the world.
Amarillo-based A-1 Rocket Industries and Veterinary Medical Providers and Perryton Aviation were honored on Oct. 17 by the Mays Business School's Center for New Ventures and Entrepreneurship at Texas A&M for positively impacting the economy with outstanding growth and determination.
By: BizStream on October 17, 2014 - 6:07am - Add new comment
FedEx Express, FedEx Ground and FedEx Freight, subsidiaries of FedEx Corp., will increase shipping rates effective Jan. 5.
FedEx Express will increase shipping rates by an average of 4.9 percent for U.S. domestic, U.S. export and U.S. import services.
FedEx Ground and FedEx Home Delivery will increase shipping rates by an average of 4.9 percent. FedEx SmartPost rates will also change.
By: BizStream on October 16, 2014 - 7:12am - Add new comment
Dillard's is pleased to further its commitment to Ronald McDonald House Charities with its 21st annual holiday fundraiser.
Since 1994, Dillard's has supported RMHC with a fundraiser benefiting its Ronald McDonald House program which provides families with seriously ill children a "home-away-from-home" while their children are receiving treatment at nearby hospitals.
By: BizStream on October 15, 2014 - 6:45am - Add new comment
Deward Adams, owner of Mr. Rooter Plumbing of Amarillo, recently received the Top Gun award from the Mr. Rooter Plumbing corporate office during the company's 2014 International Convention in Orlando, Florida, in September.
The award goes to franchise owners who achieve sales goals and reach operation benchmarks. The Top Gun recipients represent the top 10 percent of Mr. Rooter Plumbing owners across North America.
By: BizStream on October 14, 2014 - 6:41am - Add new comment
EnergyNet announced the promotion of Chris Atherton to president.
Atherton will focus on strategic business development, driving company growth and expanding on EnergyNet's client-focused agenda. He has been with EnergyNet for over 12 years and is based in Houston.
Michael Baker has been promoted to vice president of business development. He has served in various senior business development roles and is active in numerous industry associations including ADAM Energy Forum and currently serves on the board of the Texas Alliance of Energy Producers.
By: BizStream on October 13, 2014 - 6:17am - Add new comment
Architecture firm Dekker/Perich/Sabatini has received two merit awards from Engineering News Record Southwest.
The awards go to Moss Adams Office for the Interiors/Tenant Improvement category and Presbyterian Reverend Hugh Cooper Administrative Center (PHS Cooper Center) for Office/Retail/Mixed-Use.
"We're excited to receive these honors," said Andrea Hanson, Principal at Dekker/Perich/Sabatini. "It speaks to our team's commitment to delivering quality office designs that perform best for our clients."
By: BizStream on October 10, 2014 - 6:29am - Add new comment
The experience of purchasing a ticket and riding on a Greyhound bus has been made easier with the launch of its updated website and new onboard Wi-Fi platform.
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ATI remote wonder RF remote control.would it work my 2005 media pc siemens saleo p 3ghz,xp proffesional.thanks
(No answers yet. Write an answer!) 2009-09-24