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Deutz Brut Classic
Deutz (Champagne)
Sparkling wine Deutz Brut Classic (£25.07) is a Champagne from the Deutz cellar with a blend based on chardonnay and pinot Noir and 12.00º of volume of alcohol. To take with Deutz Brut Classic we recommend roast and meat. According to Uvinum users the valuation of Deutz Brut Classic is 4 points on 5 and in guides it has been reviewed: robert Parker: 90 and wine Spectator: 90.
Deutz Brut Classic Champagne transmits the Classic spirit with which William Deutz began to create them. Silky, velvety and elegant, it takes especially well with dishes of haute cuisine, but is also great for excellent quality desserts.
Deutz Brut Classic - basic data
- Type of wine:
- sparkling wine
- Other vintages:
- See
- Appellation:
- Champagne (Champagne,France)
- Cellar:
- Deutz
- Volume:
- 75 cl Other volumes
- Score:
- 9090
- Grapes:
- Pinot Meunier, Pinot Nero, Pinot Noir, Chardonnay
- Pairing:
- Starters, Desserts, Meat, Roast
- Alcohol vol.:
- 12.00%
- Type of Sparkling:
- Brut
- Allergens:
- Contains Sulfites
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Reviews about Deutz Brut Classic
Highlighted review about Deutz Brut Classic
Posted on 30/03/14 at 04.57
Deutz Brut
The dress, a gold fairly steady, this beading with great finesse. The very expressive bouquet first reveals notes of floral type (hawthorn, white flowers ,..) And aromas of toast. The palate combines the freshness of Chardonnay, l (smoothness of Pinot Black, Pinot Meunier flexibility with sleek...read complete
More reviews about Deutz Brut Classic
Posted on 12/11/14 at 16.21
- View: Deutz Brut Classic is golden yellow, intense and persistent fine bubbles
- Nose: Floral aromas of white flowers, toasted notes, ripe fruit, apple and pear
- Mouth: Silky,...
Posted on 18/02/14 at 04.55
Deutz Brut Classic from vintage 0 in 75 cl White wine from Champagneread complete
Posted on 07/02/14 at 13.10
Deutz Brut
deutz brut champagne 75 cl
Tasting Notes: Golden intense, fine and persistent bubbles Amarillo. Floral aromas, white flowers, roasted notes, ripe fruit like apple and pear. Silky, velvety and elegant.
Posted on 30/12/13 at 17.17
Deutz Classic Brut
- View: Deutz Classic Brut is deep golden yellow with fine bubbles and persistent
- Nose: floral, white flowers, toasted notes, ripe fruit, apple and pear
- Mouth: Silky, velvety and...
Posted on 21/08/13 at 04.47
Deutz Champagne Classic Brut
The most "classical" of the Deutz cuvee is far from mundane. The three different champagne grapes are blended in equal and unchanging proportions, ensuring it shows perfect harmony. The wine then...read complete
Posted on 20/03/13 at 04.42
Of intense golden yellow. On the nose floral aromas (hawthorn, white flowers, ...), followed by roasted notes, marzipan and ripe fruits (apples, pears ...). The palate is silky and elegant.
Posted on 21/02/13 at 04.45
Founded in 1838 by William Deutz, and acquired in 1993 by the household of Louis Roederer, the Maison de Champagne Deutz has launched a counter attack to regain lost ground. Today Brut Fabrice...read complete
Posted on 07/01/13 at 09.48
Champagne Deutz Brut Classic Nv
* Bronze Medal - International Wine Challenge 2011 *
Deutz is the epitome of understated excellence. Founded in 1838, the house is based in the heart of the Champagne vineyards in one of the most...
Posted on 22/12/11 at 18.17
Deutz Classic Brut
Equipped with fine bubbles, this champagne has a very distinctive bouquet with floral notes. On the palate flavors of toasted bread dominate, almonds and ripe pears. The freshness of the Chardonnay...read complete
Posted on 18/07/11 at 11.54
Deep color, characteristic of Deutz Brut Classic. Aromas that remind of acacia flowers. Reminded me of burned wood and it was a pleasant taste.
To pair it with grilled prawns.
I tried it at a...
Summary of ratings
Maker's description · Deutz
About 2 kilometers from Epernay, between the river Marne and the slopes of the Mountain of Reims, Ay is the wine-producing village oldest known in the region. Founded in 1838, the house Deutz grew under the direction of 5 generations of one family. At the end of the nineteenth century had...
Deutz Brut Classic (Pinot Meunier, Pinot Nero, Pinot Noir and Chardonnay)
Dorado intense. Fine bubbles slow release.
Elegant, medium to high intensity. Notes of apple, acacia flower with background of cakes and pastries.
The freshness of Chardonnay, Pinot Noir fruit, pinot meunier the vinosity the form this Champagne creamy on the palate and a long finish.
Pairing: haute cuisine dish with fish starring Excellent. Suitable in cold entrees and desserts.
View more Champagne Deutz
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You can also buy Deutz Brut Classic in...
- Deutz Brut Classic (DE)
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If you want to buy Deutz Brut Classic, on Uvinum you will find the best prices for Champagne Deutz. Get it in Uvinum in the easiest way and with all warranties, more than 59.000 products are available on sale, which makes us the leaders in wine, spirits and beer selling in Europe, they are now more than 38.000 clients who trusted us.


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JetSuite is acting as a broker for Phenom 100 flights operated by Solana Beach, Calif.-based Air by Jet. Air by Jet is the second operator to begin using Embraer's Phenom 100 for charter; Kansas City-based Executive AirShare made the first Phenom 100 charter flight in April. JetSuite has ordered 50 Phenom 100s and has options on 50 more. It plans to take delivery of seven this year.
Business Jet Traveler » August 2009
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Robert Mark's "
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Andre Budhan, a cofounder of defunct charter operator Platinum Jet, has pleaded guilty in U.S. District Court to conspiracy to defraud customers and brokers and impede and obstruct the FAA. The case stemmed from the 2005 crash of a Challenger 600 following takeoff at Teterboro (N.J.) Airport.
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subset: commoncrawl


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Exbury 'White Throat' azalea question...
gerry_wyomingpa(z6)July 8, 2008
I just picked up two of these on clearance in a 1 gallon size, 6.98 for both of them. I had an orange and a yellow exbury when I was living in PA, and LOVED them, there is still hope that I can get ahold of them...fingers crossed. Does anyone know if these white ones are going to have the same bloom habit, basically pom poms on a stick in the spring? Are they also slow growers? And most important, does anyone have any pictures to share of them?
Thank you in advance,
rhodyman(SE PA, USDA Z6)
The ones in PA were probably Klondike (yellow) and Gibraltar (orange).
White Throat is described in detail at the link below:
Here is a link that might be useful: Azalea 'White Throat'


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What Do You See?
Challenge: Take a look at one of these four photographs.
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Rules and Guidelines
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Publications (145)748.96 Total impact
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ABSTRACT: IL-6 can mediate proinflammatory effects, and IL-6 receptor (IL-6R) blockade as a treatment for inflammatory diseases has entered clinical practice. However, opposing effects of IL-6 have been observed in models of GN. Although IL-6 is proinflammatory in murine lupus nephritis, protective effects have been observed for IL-6 in the nephrotoxic nephritis (NTN) model of acute crescentic GN. In light of the potential dangers of IL-6-directed treatment, we studied the mechanisms underlying the contradictory findings in GN. IL-6 can signal through the membrane-bound IL-6R, which is expressed only on hepatocytes and certain leukocytes (classic), or through the soluble IL-6R, which binds the ubiquitously expressed gp130 (alternative). Preemptive treatment of mice with anti-IL-6R or anti-IL-6 worsened NTN, whereas selective blockade of alternative IL-6 signaling by the fusion protein sgp130Fc did not. FACS analysis of mouse spleen cells revealed proinflammatory macrophages express the highest levels of IL-6Rα, and in vitro treatment with IL-6 blocked macrophage proliferation. Furthermore, proinflammatory macrophages were expanded during inflammation in IL-6(-/-) mice. Late application of anti-IL-6 after establishment of adaptive nephritogenic immunity was sufficient to aggravate NTN within 2.5 days, a period when macrophages are active. Finally, NTN was aggravated in mice with macrophage-specific impairment of IL-6 classic signaling, coincident with enhanced macrophage proliferation and accumulation in the kidney. Our data thus reveal a novel mechanism in which IL-6-mediated dampening of macrophage activation protects tissues from overshooting immune responses. This finding has important implications for potential IL-6-directed therapies and supports the careful choice of recipient patients and timing. Copyright © 2015 by the American Society of Nephrology.Journal of the American Society of Nephrology 02/2015; DOI:10.1681/ASN.2014060620 · 9.47 Impact Factor
Article: Non-canonical Interleukin 23 receptor complex assembly: p40 recruits Interleukin 12 Receptor beta 1 via site II and induces p19/Interleukin 23 Receptor interaction via site III.[Show abstract] [Hide abstract]
ABSTRACT: Interleukin 23 (IL-23), composed of the cytokine subunit p19 and the soluble α receptor subunit p40, binds to the receptor complex consisting of the IL-23 receptor (IL-23R) and the IL-12 receptor β1 (IL-12Rβ1). Complex formation was hypothesized to follow the site I-II-III architectural paradigm with site I of p19 being required for binding to p40, whereas site II and site III of p19 mediate binding to IL-12Rβ1 and IL-23R, respectively. Here we show that the binding mode of p19 to p40 and of p19 to IL-23R follow the canonical site I and III paradigm but interaction of IL-23 to IL-12Rβ1 is independent of site II in p19. Instead, binding of IL-23 to the cytokine binding module (CBM) of IL-12Rβ1 is mediated by the domains 1 and 2 of p40 via corresponding site II amino acids of the IL-12Rβ1. Moreover, domains 2 and 3 of p40 were sufficient for complex formation with p19 and to induce binding of p19 to IL-23R. The Fc-tagged fusion protein of p40_D2D3/p19 did, however, not act as a competitive IL-23 antagonist but at higher concentrations induced proliferation via IL-23R but independent on IL-12Rβ1. Based on our experimental validation, we propose a non-canonical topology of the IL-23/IL-23R/IL-12Rβ1 complex. Furthermore, our data help to explain why p40 is an antagonist of IL-23 and IL-12 signaling and shows that site II of p19 is dispensable for IL-23 signaling.Journal of Biological Chemistry 11/2014; DOI:10.1074/jbc.M114.617597 · 4.60 Impact Factor
Article: Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction.[Show abstract] [Hide abstract]
ABSTRACT: Interleukin-6 (IL-6) is a multifunctional cytokine that orchestrates the immune response to a wide variety of pathophysiologic challenges but also contributes to tissue homeostasis. Furthermore, IL-6 is elevated in patients with acute myocardial infarction. Hyaluronan (HA) is an extracellular carbohydrate that has been implicated in wound healing and accumulates after acute myocardial infarction (AMI). Aim of this study was to investigate the involvement of IL-6 in the regulation of the HA-matrix in the early phase of infarct healing. In the present study, we show by the use of a blocking anti-IL-6 antibody, that endogenous IL-6 rapidly but transiently increased HA-synthase (HAS) 1 and 2 expression resulting in the formation of a HA-rich matrix acutely after AMI in mice. In vitro, IL-6 induced HAS1 and 2 via STAT3 phosphorylation in cardiac fibroblasts (CF) and supported a myofibroblastic phenotype in a HA-dependent manner. Furthermore, CCL5 and MCP1 expression were dependent on IL-6, HA-synthesis and the HA-receptor CD44 as shown in cultured CF derived from CD44 knockout mice. In vivo after AMI, blocking IL-6 decreased HA-matrix formation in the peri-infarct region and alpha-smooth muscle actin-positive myofibroblasts. Blocking IL-6 also reduced neutrophil infiltration in infarcted left ventricles. Moreover, treatment with the blocking IL-6 antibody reduced cardiac ejection fraction and increased infarct size 3 weeks after AMI. These findings support a functionally important role for IL-6 in CF by transiently inducing a HA-rich matrix that in turn promotes a myofibroblastic phenotype and inflammatory responses, and ultimately establishes a cardioprotective program after AMI.Archiv für Kreislaufforschung 11/2014; 109(6):440. DOI:10.1007/s00395-014-0440-y · 5.96 Impact Factor
Article: Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease.[Show abstract] [Hide abstract]
ABSTRACT: Interleukin (IL)-17A is regarded as an important cytokine to drive psoriasis, an inflammatory skin disease marked by increased cardiovascular mortality. We aimed to test the hypothesis that overproduction of IL-17A in the skin leading to dermal inflammation may systemically cause vascular dysfunction in psoriasis-like skin disease.Arteriosclerosis Thrombosis and Vascular Biology 10/2014; DOI:10.1161/ATVBAHA.114.304108 · 5.53 Impact Factor
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ABSTRACT: The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises of the p35/EBI3 heterodimer (EBI3 shared with IL-27). IL-35 signals via homo- or heterodimers of IL-12Rβ2, gp130 and WSX-1, which are shared with IL-12 and IL-27 receptor complexes, respectively. p35 was efficiently secreted in complex with p40 as IL-12 but not with EBI3 as IL-35 in several transfected cell lines tested which complicates the analysis of IL-35 signal transduction. p35 and p40 but not p35 and EBI3 form an inter-chain disulfide bridge. Mutation of the responsible cysteine residue (p40C197A) reduced IL-12 formation and activity only slightly. Importantly, the p40C197A mutation prevented the formation of antagonistic p40 homodimers which enabled the in vitro reconstitution of biologically active IL-12 with p35 produced in bacteria (p35bac). Reconstitution of IL-35 with p35bac and EBI3 did, however, fail to induce signal transduction in Ba/F3 cells expressing IL-12Rβ2 and gp130. In summary, we describe the in vitro reconstitution of IL-12, but fail to produce recombinant IL-35 by this novel approach.PLoS ONE 09/2014; 9(9):e107990. DOI:10.1371/journal.pone.0107990 · 3.53 Impact FactorThis article is viewable in ResearchGate's enriched formatRG Format enables you to read in context with side-by-side figures, citations, and feedback from experts in your field.
Article: Pivotal Role of Phospholipase D1 in Tumor Necrosis Factor-α–Mediated Inflammation and Scar Formation after Myocardial Ischemia and Reperfusion in Mice[Show abstract] [Hide abstract]
ABSTRACT: Myocardial inflammation is critical for ventricular remodeling after ischemia. Phospholipid mediators play an important role in inflammatory processes. In the plasma membrane they are degraded by phospholipase D1 (PLD1). PLD1 was shown to be critically involved in ischemic cardiovascular events. Moreover, PLD1 is coupled to tumor necrosis factor-α signaling and inflammatory processes. However, the impact of PLD1 in inflammatory cardiovascular disease remains elusive. Here, we analyzed the impact of PLD1 in tumor necrosis factor-α–mediated activation of monocytes after myocardial ischemia and reperfusion using a mouse model of myocardial infarction. PLD1 expression was highly up-regulated in the myocardium after ischemia/reperfusion. Genetic ablation of PLD1 led to defective cell adhesion and migration of inflammatory cells into the infarct border zone 24 hours after ischemia/reperfusion injury, likely owing to reduced tumor necrosis factor-α expression and release, followed by impaired nuclear factor-κB activation and interleukin-1 release. Moreover, PLD1 was found to be important for transforming growth factor-β secretion and smooth muscle α-actin expression of cardiac fibroblasts because myofibroblast differentiation and interstitial collagen deposition were altered in Pld1−/− mice. Consequently, infarct size was increased and left ventricular function was impaired 28 days after myocardial infarction in Pld1−/− mice. Our results indicate that PLD1 is crucial for tumor necrosis factor-α–mediated inflammation and transforming growth factor-β–mediated collagen scar formation, thereby augmenting cardiac left ventricular function after ischemia/reperfusion.American Journal Of Pathology 09/2014; DOI:10.1016/j.ajpath.2014.06.005 · 4.60 Impact Factor
Article: The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand-Mediated Humoral Immune Responses[Show abstract] [Hide abstract]
ABSTRACT: Immune cells regulate cell surface receptor expression during their maturation, activation, and motility. Although many of these receptors are regulated largely at the level of expression, protease-mediated ectodomain shedding represents an alternative means of refashioning the surface of immune cells. Shedding is largely attributed to a family of a disintegrin and metalloprotease domain (ADAM) metalloproteases, including ADAM17. Although ADAM17 is well known to contribute to the innate immune response, mainly by releasing TNF-α, much less is known about whether/how this metalloprotease regulates adaptive immunity. To determine whether ADAM17 contributes to regulating adaptive immune responses, we took advantage of ADAM17 hypomorphic (ADAM17(ex/ex)) mice, in which ADAM17 expression is reduced by 90-95% compared with wild-type littermates. In this study, we show that that ADAM17 deficiency results in spleen and lymph node enlargement, as well as increased levels of Ag-specific class-switched Ig production following immunization with OVA together with anti-CD40 mAbs and polyinosinic-polycytidylic acid. Moreover, we demonstrate that the costimulatory ligand ICOS ligand (ICOSL) is selectively downregulated on the surface of B cells in an ADAM17-specific manner, although it is not proteolitically processed by recombinant ADAM17 in vitro. Finally, we show that higher cell surface levels of ICOSL in ADAM17(ex/ex) mice may contribute to the development of excessive Ab responses. Therefore, our data suggest a functional link between ADAM17 and ICOSL in controlling adaptive immune responses.The Journal of Immunology 08/2014; DOI:10.4049/jimmunol.1302893 · 5.36 Impact Factor
Article: Alternative Intronic Polyadenylation Generates the Interleukin-6 Trans-signaling Inhibitor sgp130-E10[Show abstract] [Hide abstract]
ABSTRACT: Interleukin (IL)-6 signals via a receptor complex composed of the signal-transducing β-receptor gp130 and the non-signaling membrane-bound or soluble IL-6 receptor α (IL-6R, sIL-6R), which is referred to as classic and trans-signaling, respectively. IL-6 trans-signaling is functionally associated with the development of chronic inflammatory diseases and cancer. Soluble gp130 (sgp130) variants are natural inhibitors of trans-signaling. Differential splicing yields sgp130 isoforms. Here, we describe that alternative intronic polyadenylation (IPA) in intron 10 of the gp130 transcript results in a novel mRNA coding for a sgp130 protein isoform (sgp130-E10) of 70-80 kDa. The sgp130-E10 protein was expressed in vivo in human peripheral blood mononuclear cells (PBMCs). To assess the biological activity of sgp130-E10, we expressed this variant as Fc-tagged fusion protein (sgp130-E10Fc). Recombinant sgp130-E10Fc binds to a complex of IL-6 and sIL-6R, but not to IL-6 alone, and specifically inhibits IL-6 trans-signaling. Thus, it might play an important role in the regulation of trans-signaling in vivo.Journal of Biological Chemistry 06/2014; 289(32). DOI:10.1074/jbc.M114.560938 · 4.60 Impact Factor
Article: Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis[Show abstract] [Hide abstract]
ABSTRACT: Interleukin (IL)-6-deficient, but not IL-6 receptor (IL-6R)‑deficient mice present with a delayed skin wound healing phenotype. Since IL-6 solely signals via the IL-6R and glycoprotein 130 (gp130), Il-6r-deficient mice are expected to exhibit a similar phenotype as Il-6-deficient mice. However, p28 (IL-30) and ciliary neurotrophic factor (CNTF) have been identified as additional low‑affinity ligands of the IL-6R/gp130/LIFR complex. IL-6 plays an inflammatory and regenerative role in inflammatory bowel disease (IBD). In the present study, we compared Il-6r-deficient mice with mice treated with neutralizing IL-6 monoclonal antibody (mAb) in a model of dextran sodium sulfate (DSS)-induced colitis. Our results, in agreement with those of previous reports, demonstrated that IL-6 mAbs slightly attenuated DSS-induced colitis during the regeneration phase. Il-6r-deficient mice and mice with tissue-specific deletion of the Il-6r in the myeloid cell lineage (LysMCre) with acute and chronic DSS-induced colitis were, however, indistinguishable from wild-type mice. Our data suggest that IL-6 and IL-6R have an additional role in colitis, apart from the IL-6/IL-6R classic and trans-signaling.International Journal of Molecular Medicine 06/2014; 34(3). DOI:10.3892/ijmm.2014.1825 · 1.88 Impact FactorThis article is viewable in ResearchGate's enriched formatRG Format enables you to read in context with side-by-side figures, citations, and feedback from experts in your field.
Article: The Interleukin-6 Receptor Asp358Ala Single Nucleotide Polymorphism rs2228145 Confers Increased Proteolytic Conversion Rates by ADAM Proteases.[Show abstract] [Hide abstract]
ABSTRACT: The pleiotropic activities of Interleukin (IL-)6 are controlled by membrane-bound and soluble forms of the IL-6 receptor (IL-6R) in processes called classic and trans-signaling, respectively. The coding single nucleotide polymorphism (SNP) rs2228145 of the Interleukin 6 receptor (IL-6R Asp358Ala variant) is associated with an 2fold increase in soluble IL-6R (sIL-6R) serum levels resulting in reduced IL-6-induced C-reactive protein (CRP) production and a reduced risk for coronary heart disease. It was suggested that the increased sIL-6R level lead to decreased IL-6 classic or increased IL-6 trans-signaling. Irrespective of the functional outcome of increased sIL-6R serum level, it is still under debate, whether the increased sIL-6R serum levels emerged from differential splicing or ectodomain shedding. Here we show that increased proteolytic ectodomain shedding mediated by the A Disintegrin and metalloproteinase domain (ADAM) proteases ADAM10 and ADAM17 caused increased sIL-6R serum level in vitro as well as in healthy volunteers homozygous for the IL-6R Asp358Ala allele. Differential splicing of the IL-6R appears to have only a minor effect on sIL-6R level. Increased ectodomain shedding resulted in reduced cell-surface expression of the IL-6R Asp358Ala variant compared to the common IL-6R variant. In conclusion, increased IL-6R ectodomain shedding is a mechanistic explanation for the increased serum IL-6R levels found in persons homozygous for the rs2228145 IL-6R Asp358Ala variant.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 05/2014; DOI:10.1016/j.bbadis.2014.05.018 · 5.09 Impact Factor
Article: The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates IL-6R- but retains CNTFR-dependent signaling via gp130/LIFR.[Show abstract] [Hide abstract]
ABSTRACT: Ciliary neurotrophic factor (CNTF) is a neurotrophic factor with therapeutic potential for neurodegenerative diseases. Moreover, therapeutic application of CNTF reduced body weight in mice and humans. CNTF binds to high or low affinity receptor complexes consisting of CNTFR/gp130/LIFR or IL-6R/gp130/LIFR, respectively. Clinical studies of the CNTF derivative Axokine revealed intolerance at higher concentrations, which may rely on the low-affinity binding of CNTF to the IL-6R. Here, we aimed to generate a CNTFR-selective CNTF variant (CV). CV-1 contained the single amino acid exchange R28E. R28 is in close proximity to the CNTFR binding site. Using molecular modelling we hypothesised that R28 might contribute to IL-6R/CNTFR plasticity of CNTF. CV-2 to CV-5 were generated by transferring parts of the CNTFR binding site from Cardiotrophin-like cytokine (CLC) to CNTF. CLC selectively signals via the CNTFR/gp130/LIFR complex, albeit with a much lower affinity compared to CNTF. As shown by immunoprecipitation, all CNTF variants retained the ability to bind to CNTFR. CV-1, CV-2 and CV-5, however, lost the ability to bind to IL-6R. Although all variants induced cytokine-dependent cellular proliferation and STAT3 phosphorylation via CNTFR/gp130/LIFR, only CV-3 induced STAT3 phosphorylation via IL-6R/gp130/LIFR. Quantification of CNTF-dependent proliferation of CNTFR-gp130-LIFR expressing cells indicated that only CV-1 was as biologically active as CNTF. Thus, the CNTFR-selective CV-1 will allow discriminating between CNTFR- and IL-6R-mediated effects in vivo.Journal of Biological Chemistry 05/2014; DOI:10.1074/jbc.M114.568857 · 4.60 Impact Factor
Article: A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor[Show abstract] [Hide abstract]
ABSTRACT: A Disintegrin And Metalloprotease-17 (ADAM17) is a major sheddase involved in the regulation of a wide range of biological processes. Key substrates of ADAM17 are the interleukin-6 receptor (IL-6R) and tumour necrosis factor-α (TNF-α). The extracellular region of ADAM17 consists of a pro-, a catalytic, a disintegrin and a membrane-proximal domain (MPD) as well as a small stalk region. This study demonstrates that this juxtamembrane segment is highly conserved, α-helical and involved in IL-6R binding. This process is regulated by the structure of the preceding MPD, which acts as molecular switch of ADAM17 activity operated by a protein-disulfide isomerase. Hence, we have termed the conserved stalk region "Conserved ADAM-SeventeeN Dynamic Interac-tion Sequence" (CANDIS). Finally, we identified the region in IL-6R, which binds to CANDIS. In contrast to the type-I transmembrane protein IL-6R, CANDIS does not bind the type-II transmembrane protein TNF-α, demonstrating fundamental differ-ences in the respective shedding by ADAM17.Journal of Biological Chemistry 04/2014; 289(23). DOI:10.1074/jbc.M114.557322 · 4.60 Impact Factor
Article: A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice[Show abstract] [Hide abstract]
ABSTRACT: Tumor necrosis factor alpha (TNF) plays a pivotal role in chronic inflammatory diseases such as rheumatoid arthritis and Crohn's disease. Although anti-TNF antibody therapy is now commonly used to treat patients suffering from these inflammatory conditions, the cost of treatment continues to be a concern. Here, we developed a rice transgenic system for the production of a llama variable domain of a heavy-chain antibody fragment (VHH) specific for mouse TNF in rice seeds (MucoRice-mTNF-VHH). MucoRice-mTNF-VHH was produced at high levels in the rice seeds when we used our most recent transgene-overexpression system with RNA interference technology that suppresses the production of major rice endogenous storage proteins while enhancing the expression of the transgene-derived protein. Production levels of mTNF-VHH in rice seeds reached an average of 1.45% (w/w). Further, approximately 91% of mTNF-VHH was released easily when the powder form of MucoRice-mTNF-VHH was mixed with PBS. mTNF-VHH purified by means of single-step gel filtration from rice PBS extract showed high neutralizing activity in an in vitro mTNF cytotoxicity assay using WEHI164 cells. In addition, purified mTNF-VHH suppressed progression of collagen-induced arthritis in mice. These results show that this rice-expression system is useful for the production of neutralizing VHH antibody specific for mTNF.Journal of Biotechnology 04/2014; 175. DOI:10.1016/j.jbiotec.2014.02.005 · 3.18 Impact Factor
Article: Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.[Show abstract] [Hide abstract]
ABSTRACT: The Janus kinase / signal transducer and activator of transcription (Jak/STAT) pathway can be activated by many different cytokines, among them all members of the Interleukin (IL-)6 family. Dysregulation of this pathway, resulting in its constitutive activation, is associated with chronic inflammation and cancer development. In the present study, we show that activity of protein kinase II (CK2), a ubiquitously expressed serine/threonine kinase, is needed for induced activation of STAT1 and STAT3 by IL-6 classic and trans-signaling, IL-11, IL-27, oncostatin M (OSM), leukemia inhibitory factor (LIF) and cardiotrophin-1 (CT-1). Inhibition of CK2 efficiently prevented STAT phosphorylation and inhibited cytokine-dependent cell proliferation in a Jak1-dependent manner. Conversely, forced activation of CK2 alone was not sufficient to induce activation of the Jak/STAT signaling pathway. Inhibition of CK2 in turn inhibited Jak1-dependent STAT activation by oncogenic gp130 mutations. Furthermore, CK2 inhibition diminished the Jak1- and Src kinase-dependent phosphorylation of a constitutively active STAT3 mutant recently described in human large granular lymphocytic leukemia. In conclusion, we characterize CK2 as an essential component of the Jak/STAT pathway. Pharmacologic inhibition of this kinase is therefore a promising strategy to treat human inflammatory diseases and malignancies associated with constitutive activation of the Jak/STAT pathway.Oncotarget 03/2014; · 6.63 Impact Factor
Article: Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain[Show abstract] [Hide abstract]
ABSTRACT: IL-6 is implicated in the pathogenesis of various neuroinflammatory and neurodegenerative disorders of the CNS. IL-6 signals via binding to either the membrane bound IL-6Rα (classic signaling) or soluble (s)IL-6Ra (trans-signaling) that then form a complex with gp130 to activate the JAK/STAT signaling pathway. The importance of classic versus trans-signaling in mediating IL-6 actions in the living CNS is relatively unknown and was the focus of this investigation. Bigenic mice (termed GFAP-IL6/sgp130 mice) were generated with CNS-restricted, astrocyte-targeted production of IL-6 and coproduction of the specific inhibitor of IL-6 trans-signaling, human sgp130-Fc. Transgene-encoded IL-6 mRNA levels were similar in the brain of GFAP-IL6 and GFAP-IL6/sgp130 mice. However, GFAP-IL6/sgp130 mice had decreased pY(705)-STAT3 in the brain due to a reduction in the total number of pY(705)-STAT3-positive cells and a marked loss of pY(705)-STAT3 in specific cell types. Blockade of trans-signaling in the brain of the GFAP-IL6 mice significantly attenuated Serpina3n but not SOCS3 gene expression, whereas vascular changes including angiogenesis and blood-brain barrier leakage as well as gliosis were also reduced significantly. Hippocampal neurogenesis which was impaired in GFAP-IL6 mice was rescued in young GFAP-IL6 mice with cerebral sgp130 production. Finally, degenerative changes in the cerebellum characteristic of GFAP-IL6 mice were absent in GFAP-IL6/sgp130 mice. The findings indicate that in the CNS: (1) sgp130 is able to block IL-6 trans-signaling, (2) trans-signaling is important for IL-6 cellular communication with selective cellular and molecular targets, and (3) blocking of trans-signaling alleviates many of the detrimental effects of IL-6.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 02/2014; 34(7):2503-13. DOI:10.1523/JNEUROSCI.2830-13.2014 · 6.75 Impact Factor
01/2014; 19(Suppl 1):S17. DOI:10.1186/2047-783X-19-S1-S17
Article: The Interleukin-6 Receptor Asp358Ala Single Nucleotide Polymorphism rs2228145 Confers Increased Proteolytic Conversion Rates by ADAM Proteases[Show abstract] [Hide abstract]
ABSTRACT: The pleiotropic activities of Interleukin (IL-)6 are controlled by membrane-bound and soluble forms of the IL-6 receptor (IL-6R) in processes called classic and trans-signaling, respectively. The coding single nucleotide polymorphism (SNP) rs2228145 of the Interleukin 6 receptor (IL-6R Asp358Ala variant) is associated with an 2fold increase in soluble IL-6R (sIL-6R) serum levels resulting in reduced IL-6-induced C-reactive protein (CRP) production and a reduced risk for coronary heart disease. It was suggested that the increased sIL-6R level lead to decreased IL-6 classic or increased IL-6 trans-signaling. Irrespective of the functional outcome of increased sIL-6R serum level, it is still under debate, whether the increased sIL-6R serum levels emerged from differential splicing or ectodomain shedding. Here we show that increased proteolytic ectodomain shedding mediated by the A Disintegrin and metalloproteinase domain (ADAM) proteases ADAM10 and ADAM17 caused increased sIL-6R serum level in vitro as well as in healthy volunteers homozygous for the IL-6R Asp358Ala allele. Differential splicing of the IL-6R appears to have only a minor effect on sIL-6R level. Increased ectodomain shedding resulted in reduced cell-surface expression of the IL-6R Asp358Ala variant compared to the common IL-6R variant. In conclusion, increased IL-6R ectodomain shedding is a mechanistic explanation for the increased serum IL-6R levels found in persons homozygous for the rs2228145 IL-6R Asp358Ala variant.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 01/2014; · 5.09 Impact Factor
Article: Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine[Show abstract] [Hide abstract]
ABSTRACT: T cell immunoglobulin and mucin domain 1 and 4 (TIM-1 and -4) proteins serve as phosphatidylserine receptors to engulf apoptotic cells. Here we show that human TIM-1 and TIM-4 proteins are targets of A Disintegrin And Metalloprotease (ADAM)-mediated ectodomain shedding resulting in soluble forms of TIM-1 and TIM-4. We identified ADAM10 and ADAM17 as major sheddases of TIM-1 and TIM-4 as shown by protease-specific inhibitors, the ADAM10 prodomain, siRNA and ADAM10/ADAM17 deficient murine embryonic fibroblasts (MEFs). TIM-1 and TIM-4 lacking the intracellular domain were efficiently cleaved after ionomycin- and PMA-treatment, indicating that the intracellular domain was not necessary for ectodomain shedding. Soluble TIM-1 and -4 were able to bind to phosphatidylserine, suggesting that soluble TIM-1 and -4 might act as negative regulators of cellular TIM-1 and -4. In summary, we describe TIM-1 and TIM-4 as novel targets for ADAM10- and ADAM17-mediated ectodomain shedding.Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 01/2014; 1843(2):275–287. · 5.30 Impact Factor
Article: Polo-like Kinase 2, a Novel ADAM17 Signaling Component, Regulates Tumor Necrosis Factor similar to Ectodomain Shedding[Show abstract] [Hide abstract]
ABSTRACT: A disintegrin and metalloprotease 17 (ADAM17) controls pro- and anti-inflammatory signaling events by promoting ectodomain shedding of cytokine-precursors and cytokine receptors. Despite the well documented substrate repertoire of ADAM17 little is known about regulatory mechanisms, leading to substrate recognition and catalytic activation. Here we report a direct interaction of the acidophilic kinase polo-like kinase 2 (PLK2, also known as SNK) with the cytoplasmic portion of ADAM17 through the C-terminal noncatalytic region of PLK2 containing the Polo-box domains (PBDs). PLK2 activity leads to ADAM17 phosphorylation at serine-794, which represents a novel phosphorylation site. Activation of ADAM17 by PLK2 results in the release of pro-TNFα and TNFRs from the cell surface and pharmacological inhibition of PLK2 leads to down-regulation of LPS-induced ADAM17-mediated shedding on primary macrophages and dendritic cells. Importantly, PLK2 expression is upregulated during inflammatory conditions increasing ADAM17-mediated proteolytic events. Our findings suggest a new role of PLK2 in the regulation of inflammatory diseases by modulating ADAM17 activity.Journal of Biological Chemistry 12/2013; 289(5). DOI:10.1074/jbc.M113.536847 · 4.60 Impact Factor
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ABSTRACT: Cytokines receptors exist in membrane bound and soluble form. A soluble form of the human IL-6R is generated by limited proteolysis and alternative splicing. The complex of IL-6 and soluble IL-6R stimulates target cells not stimulated by IL-6 alone, since they do not express the membrane bound IL-6R. We have named this process trans-signaling. Soluble gp130 is the natural inhibitor of IL-6/soluble IL-6R complex responses. Recombinant soluble gp130 protein is a molecular tool to discriminate between gp130 responses via membrane bound and soluble IL-6R responses. Neutralizing monoclonal antibodies for global blockade of IL-6 signaling and the sgp130Fc protein for selective blockade of IL-6 trans-signaling have been used in several animal models of human diseases. Using the sgp130Fc protein or sgp130Fc transgenic mice we demonstrate in models of inflammatory bowel disease, peritonitis, rheumatoid arthritis, atherosclerosis pancreatitis, colon cancer, ovarian cancer and pancreatic cancer, that IL-6 trans-signaling via the soluble IL-6R is the crucial step in the development and the progression of the disease. Therefore, sgp130Fc is a novel therapeutic agent for the treatment of chronic inflammatory diseases and cancer and it undergoes phase I clinical trials as an anti-inflammatory drug since June 2013.Seminars in Immunology 12/2013; 26(1). DOI:10.1016/j.smim.2013.11.002 · 5.93 Impact Factor
Top Journals
Heinrich-Heine-Universität Düsseldorf
Düsseldorf, North Rhine-Westphalia, Germany
- Institute of Biochemistry and Molecular Biology II
Christian-Albrechts-Universität zu Kiel
Kiel, Schleswig-Holstein, Germany
- • Institute of Biochemistry
- • Faculty of Medicine
Cardiff University
Cardiff, WLS, United Kingdom
- • Department of Infection, Immunity and Biochemistry
- • Department of Medical Biochemistry and Immunology
- • School of Biosciences
Harvard Medical School
Boston, MA, United States
- Department of Medicine
Kurume University
Куруме, Fukuoka, Japan
- School of Medicine
Leibniz Institute of Plant Genetics and Crop Plant Research
Gatersleben, Saxony-Anhalt, Germany
- Department of Molecular Genetics


text: The Mindsnap wiki last edited by jeffreyv2512 on 05/29/13 03:01PM View full history The League call in Amanda Waller to deprogram the brain-washed Blue Beetle.Oberon goes down to Bell-Reeve to ask for Amanda Waller's help in deprogramming Beetle (see last Issue for what happened), she excepts and flies up to New York where Max, J'onn and Batman have locked Blue Beetle in Max's office and have barred anyone from seeing him until they figure out what's going on.Waller meets with Max, J'onn and Batman and they explain the Queen Bee has brain washed Beetle and they need Waller's help to undo the programing. When Waller meets with Beetle she mistakenly says the trigger phrase, "Biayla my Biayla". This causes Beetle to attack her but because Beetle is still hurting from his battle with Huntress and Batman, Waller is able to knock him out.Waller then explains to Max and the rest that she will try hypnoses on Beetle but Queen Bee may have set up fail safes in Beetle Mind to stop that. They agree to try and it seems to be working. Beetle relives being back in Biayla with Booster watching TV, then they get hit with sleeping gas, then when beetle wakes he is in the presence of Queen Bee and Jack-o-lantern. Before he can learn anything useful one of Queen Bee's fail safes in Beetles mind trips and Beetle has a stroke and goes into a coma.Once Beetle is taken to the hospital Waller apologizes to Batman for failing. Batman doesn't blame her, he knows the team needs the help of Doctor Fate.Meanwhile the rest of the team deals with the fat that Beetle is in trouble in their own ways. Booster plans revenge, with Ice. Oberon and Fire get closer. And Guy beats up a litter bug.


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The cab driver taking me to the Washington Nationals baseball game on July 4 is from Bangladesh. I ask him how he got here. He said his father "won the immigration lottery" some years back, was admitted under U.S. immigration law and eventually became a citizen, as did his son. He is proud to be an American and said after he dropped me off he was going to a traditional Fourth of July party to celebrate America's independence.
There are many ways to lose freedom — conquering armies, surrendering without a fight. Unfortunately, we are currently surrendering our freedom, not to a foreign power, but to our own government.
The growth, reach, and cost of big government is happening before our eyes and eroding our liberty, largely because too many Americans are not familiar with the brilliant system of government our Founders established. Progressives prefer a "living Constitution," which is constantly changing to conform to their ideology. What it is not is the Constitution established by the Founders.
President Obama appears to have forgotten — or ignored — why we have elections. One reason is to stop, or slow down, an agenda the public doesn't like.
When polls began reflecting buyer's remorse about Mr. Obama in 2010, voters elected a Republican majority in the House of Representatives and might well have done the same in the Senate in 2012 were it not for some weak GOP candidates, especially in Nevada and Delaware.
People who refuse to drink the Kool-Aid known as global warming-climate change are not just "deniers"; we are guilty of a "nihilistic refusal" to address the issue. So says a Washington Post editorial commenting favorably on Monday's Supreme Court ruling that allows the Environmental Protection Agency, under certain limits, to proceed under the Clean Air Act to regulate major sources of greenhouse-gas emissions.
It is a line I have used to open speeches on the lecture circuit for years and it never fails to get a laugh: "I'm happy to be here tonight from Washington, D.C., where the only politicians with convictions are in prison."
George W. Bush never claimed to be prescient, but here he is in 2007, warning us what would happen if the United States prematurely pulled its troops out of Iraq before Iraqi forces were sufficiently trained, equipped and motivated to defend the country we gave back to them after the ouster of Saddam Hussein:
"It is rather for us to be here dedicated to the great task remaining before us — that from these honored dead we take increased devotion to that cause for which they gave the last full measure of devotion — that we here highly resolve that these dead shall not have died in vain..." (The Gettysburg Address)
No life is more wasted than one lost in vain.
I expected nothing but effusive praise from major media for Hillary Clinton's new book, "Hard Choices," much like the mass exaltation it showered on Barack Obama, America's first African-American president.
Initially that seemed where the reviews were headed.
Defenders of President Obama's release of five Taliban terrorists from the U.S. prison at Guantanamo Bay, Cuba in exchange for Army Sgt. Bowe Bergdahl cite as justification Israel's history of swapping hundreds of Palestinian prisoners for one or two Israel soldiers.
As strong an ally and example of democracy as Israel is, especially in a region sorely lacking in either, Israel is not the United States. Israel has its own interests and purpose for its actions. The world looks to the United States for leadership and in this president and his administration it has found little.
Given the numerous studies revealing how American education lags behind instruction in other countries in disciplines once thought to be essential, it should come as no surprise that on the 70th anniversary of D-Day, a lot of people are clueless about central elements of the Allied invasion of the European continent on June 6, 1944.
Peninsula Clarion ©2015. All Rights Reserved.


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Dems = absurdly optimistic PITTSBURGH (MarketWatch) The actual federal debt entered the $ trillion the week. Whats more remarkable than the amount of zeros in the fact that figure is of which Washington somehow didnt look at this coming. The Congressional Budget Office accounts for predicting the pricing effects of insurance policy changes. Politicians cite CBO statistics when telling us what things to expect later on. But it seems that CBO estimates, taken out of any very limited circumstance, arent very correct. Every January, CBO forecasts the. economy for eachof the subsequent years. Because, the agency possesses underestimated the twelve-monthly debt in from tries.. Almost % of the time, the CBO delivers (and politicians parrot) any ridiculously optimistic of the future. R. Ten years back, the CBO expected that wed get $ trillion indebted by now. From $ trillion, the reality is more thantimes as bad. Unfortunately, thats par for that course. Since, the agencys forecasts from the debt or more years on the future have happen to be % too low normally even ignoring typiy the *** recession. Presently, the CBO estimates how the federal debt might hit $ trillion just by. But if that forecast can also be off by %, well actually possibly be facing a govt debt of $ trillion by then. What will our country appear to be with a money trillion debt? The CBO features a good history of predicting gross national product, and them predicts s current economic climate will exceed usd trillion. That is going to put our consumer debt at almost % about GDP, or concerning where Greece will be today.
I wish to make Liverwurst Can I employ a Food Saver vaccuseal bag rather than the muslin casing or perhaps hog bung? I'd like to use the bag as the casing for any sausage mix and after that poach the finished product while in the sealed bag. ....... I seriously don't want to invest/go to the trouble to find/make a new muslin bag.... Just about any suggestions? clean white-colored Tee shirtReally?! How to make that deliver the results? Tie off underneath and fill plus roll it someway and tie off the top? It sounds like it's import tattoo designs foot ant for the water to soak through...? I seriously don't care about the shape of the particular finished product. I'm able to always repack it later after it is really cooked. I enjoy the help.
Timing belt or even chain? Geo Prizm, aka Toyota Hi, To begin with, I want to be familiar with whether this vehicle gets the timing belt, or could it be the timing stringed? I'm told of which timing chains survive forever, whereas timing belts you should not. I have recently been told that utilizing some cars, such as Honda, you are in the creek so far as engine damage is involved if the greek turkey recipe sucker button snaps, but with Toyota, that's not the case, and that it all just means a ride using a tow truck to garage and whatever it costs to interchange it.. I am low income currently, my car comes with k miles onto it. I bought the software at k and do not know whether that will belt or sequence or whatever is actually replaced. thanks! You need to tell whoever assured you that to ma sewing pinch pleats ke sure you... ... STFU when it arrives to cars from now on, as they needless to say know shit with regards to automotive anything. That car includes a timing belt on interference engine. If it snaps it's most probably that you are going to end up by using a mess in truth be told there. If you are unsure within the medical been done, it is best to get it completed ASAP at the fact that mileage. Generally the h2o pumps are changed combined with the timing belt. timing belt you're correct if the particular belt breaks that you are only out an important tow. either wait to you have the money or until something breaks such as water pump. how ever milage is high and also the belt will possibly not last forever. so when you do it it is advisable to replace water pump and check tensioner along with idler bearingsDon't play this fucktard... ... he doesn't be aware of wtf he's referring to. If you will need further proof, you can look at the Dayco web page, who makes this timing belt. If it's a. L Component Number: DY Producer Number: If that's a. L Part Wide variety: DY Manufacturer Wide variety: Either way, it is an interference generator. that's for a fabulous metro... not some sort of prizmWrong dipshit. Metro never came with a. OR some sort of.. Try reading all over again fucking moron. pull the uppr cover and take a look. it should come to be obvious to should it be still good as well as not. Honda aren't valve benders the majority of arent, later erinarians were, not a whole lot newer ones.
clean-up The more I understand this small small business with potential, desirable it sounds. nyone accompanied by a negative take for this business other as opposed to competition and losing employees on their starting their private washing service? That kew gardens surrey will happen THis can happen a lot thanksgiving 2005 date . You'll have to offer them a very good reason not to. Insurance protection, profit sharing?? keep in mind that columbia i will be relocating that will either columbia or even temple tx in the next month for work relocation pending features. if i find both offers which will you locals recommend i take? mo job pays k and then the tx job compensates k, same type of job awfully for each area. tx hospital primarily based fish market sunnyvale , mo university primarily based.
Anyone work with Primerica? I just spoke to a fewin of which company. i just was going to get some responses and insight to our company and anyones encounter.. Would you recommned cooperating with them? ThanksAsked often. Try this: PS: These people suck. MLM insurance protection Essentially you sole make money if you're able to convince your close friends and relatives to obtain expensive life insurance policy. mlm? nah. a good mlm requires which usually salespeople purchase solution. don't think that's the case with personal services. and they distribute to more than family and friends. and, no, aflac does not own primerica, tend to be they an marketing either. wow, have you been stupid, or whatever? you didn't look this way until you opened the mouth area, but now you appear to be really stupid. oh yea well. you probably can't help. ONce you receive a large gardens hamilton ontario umbrella in you it is fabulous, but getting of which training and umbrella may be the hardest years you are likely to ever live. Yes, Division of AFLAC, I believe, and they prey on online resumes. For those who have the word "sales" or possibly "marketin windsurfing videos comedy g" or "sucker" with your resume, they will endeavor to recruit you will. Sorry. info with Primerica Primerica as well as Travelers are actually owned by Citigroup, not really AFLAC. The company sells life coverage and annuities. Its products are higher priced than equivalent merchandise from companies by means of higher financial recommendations. The business plan assumes an expensive attrition rate, and renewal revenue not paid that will representatives who get out of contribute substantially towards the bottom line. It is comparable to MLM, in that person gets overrides at the sales of most people he recruits. If you wish to be a insurance agent -- and additionally good companies have good agents and pay them well -- I might suggest you seek for a company with some rating from. Best Company of a minimum of A, and most likely A+ or A++. Those would be the top ratings by Best. Don't possibly be confused by ranks from SP or simply Weiss. They usage different rating cooking steak stove programs, and A, A+ and A++ aren't their high reviews.
Some reasons why our govt and so fucking stupid? they keep aiming to shove more credit card debt down people's throats, when an excess of debt has been the principal problem. Loaning people revenue knowing they dont provide the means to repay is so fucking silly yet nobody will get it. Bilderberg Cluster is behind that debt-slavery. Without unsecured debt, America doesn't contain a business model. While not debt, Capitalism is without a doubt. Debt is this Tough for visitors to accept that, however is what it is actually. No debt. Very little growth. End for story. Capitalism will be able to exist in a debtless contemporary society -- bankers are for instance the mafia -- that they need their vig. Where has Capitalism EVER existed at a debtless Never-Never Land fails to count.
getting started an ecommerce web page in CA what does an individual need from some sort of legal perspective selling goods online? I realize Now i need a business not less than. My lawyer (actually spouse and ren friend) is a doofus and isn't going to know much with regards to ecommerce. you'll here is a resale as wellOK, but I fork out sales tax to people I sell off to in CALIFORNIA right? BTW, does an individual make all revenue tax payments to your county where My spouse and i live? This whole thing can be described as bit bizarre. My website would probably be hosted somewhere while in the midwest. I are living in SF, and my customers is often from anywhere! Its not fair in my circumst civil food war ances to collect SF sales tax from a professional who lives during another county, or probably another country. FLORIDA sales tax e for express board of equalization and locate the state levy office nearest you actually. the sales permit application is easy and they acquired a monthly training seminar which gives u the ABC approximately sales tax. fantastic luckyou don't pay back sales tax to help people you distribute to! gah, I meant OBTAIN sales tax fromIt's actually very easy to use Here's what you would like: - A destination to host a webpage - A webdesigner -- A Merchan'ts credit account - A shopping cart software system built into your blog - Accounts with the shipping companies You can keep them be warehousing and physiy shipping items yourself, or re-selling? If your primary company has any presence in California, which it does if you ever live here, then if you incorporate you'll want to pay the dollar /year "privilege of accomplishing business in California" overtax. You will also need to charge salestax to people in california who obtain the goods, and in different other state that your chosen business has a new physical presence.. A websever doesn't seriously count.
Feasibility from finding quick, technical staffing , work? I'm from NYC and surely have to depart Barcelona, where Searchi art activity sheets ng for. Desperately want to transfer direct to San, and yet I'm completely smashed. I have a long time of high-level hanging around experience (incl mgmt). what's the feasibility connected with my finding work within a week?many days? I'd also be able to temp and have got a year college degree. not a possibility, you'll be to the streetHA HA ' HA - THAT'S WHY RIGHT! HAHAHAHAHAHAHAHAHHA You feel you can go to San Francisco and find a job? Who cares in relation to your year degree. There are NO JOBS if anyone is like you. Bay Area is actually looking for HB VISA So if you do not eat curry, with no vowels in the name -you are outside luck!


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A New Jersey task force report says teens, minorities, unmarried mothers and women with lower levels of education are less likely to get early prenatal care. The panel recommended that the state increase pregnancy education, expand access to health insurance and provide earlier prenatal care for women.
View Full Article in:Philly.com (Philadelphia)
Published in Brief:


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2061 Nantucket Terrace
North Port, Florida, 34286
Commute to Downtown North Port
Almost all errands require a car.
It is possible to get on a bus.
Score Details
2061 Nantucket Terrace has a Walk Score of 9 out of 100. This location is a Car-Dependent neighborhood so almost all errands require a car.
This location is in North Port.
The closest school is Cranberry Elementary School.
The closest coffee shop is Aroma Coffee Services. The closest restaurant is R & C Foods LLC.
Explore how far you can travel by car, bus, bike and foot from 2061 Nantucket Terrace.
2061 Nantucket Terrace has minimal transit which means it is possible to get on a bus.
Bus lines:
0.6 mi
0.6 mi
View all North Port apartments on a map.
Popular apartment searches include pool, single family and furnished. View all North Port apartments and rentals.
This location is in the city of North Port, FL. North Port has an average Walk Score of 6 and has 57,357 residents.Learn More About North Port


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Why Even SMEs Should Outsource – Infographic
Looking for REAL data on business outsourcing? This infographic shows you quick facts to help you decide in considering outsourcing as you continue to grow your business. Even if you are a small or medium enterprise business, outsourcing is now inevitable for growth.


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Can TV for kitchen double as computer yet?? Technology status?
Apologies in advance if this is a dumb question.
We have cable TV (non digital) and cable internet so crossing over to all digital is an option.
I have a newer Dell desktop in an adjacent study that I recall has the capacity to drive a small TV - though I did not opt for a TV tuner in my configuration on that unit.
I've researched TVs and a medium TV screen would be fine for the kitchen. 24-30 LCD with cable card would be a nice option. Or a thinner CRT if it goes in a corner and we pass on digital for now.
Questions: how close is technology to integrating the TV and computer elements of family life? Should I be looking to plan and run display screen cable from a desk area to the TV? Someone posted their new Sony had a USB port but it sounded more for viewing picture files than for internet- is USB how this will go? Or will it be wireless like the router for my laptop?
I'm not qiute getting what I need with a search here. Is there a place on the net or a magazine that can get me up to speed on what exists and what to plan for? I see plenty on explaining, say plasma vs. LCD, 1080 blah blah blah, -so I'm pretty clear on the TV issues. And then I see hyper techo geek articles which I cannot at all comprehend about AV cutting edge stuff.
I just want to understand a little better what is available now for integrating these two big areas of cords, screens and cables. I like to have a plan, buy once and ride with that for a decade or two. Thanks!
Ooh. "Riding for a decade or two" with the pace of technology today is ... well, it's not going to leave you very happy, I don't think. 20 years ago, an IBM AT was a state of the art computer and the (commercial) Internet was a twinkling in someone's eyes.
What you're talking about can be done in a slightly different manner than you're stating. There are combination LCD monitors/TV monitors (many of which come with built-in tuners) which can be used to show TV programs on your computer screen (sometimes as picture-in-picture). I'm not aware of too many LCD TVs which advertise the ability to hook up a monitor, but I will admit to not paying much attention to that market because ... well, OK. I don't watch that much TV and my 20" Sony CRT will be here till it dies. :-)
Anyway, it is possible to do this now. One thing to think about, though, is whether your family is OK with TV use competing with computer use on the same box. If you have another computer (for the kids or whatever), it's far more do-able to combine the two. If you want to watch TV while the kids want to get info on harbor seals for a school project, well, ...
Another thing: right now wireless video is not quite there. Video (especially high-definition) takes a tremendous amount of bandwidth; if you can use it at all on your wireless network, everyone else on that network will know about it. At least for now, a wire is best.
As far as learning more, I would search for the term "convergence" along with TV or video or computer, etc.
thanks steve. I was thinking more of running the TV for a good while, the computers I am resigned to upgrading. And doing that is actually fun.
I recall my (way wealthy) sister in a rehab in 2002 had a wall TV screen somehow hooked up to her husband's computer in his study. Work at the desk, but the monitor is on the wall across the room like a large LCD. They likely paid high end money for that set up back then. Just wondered if that was filtering down to being in range for the rest of us.
I really don't know what is out there...
You can hook up a computer to a TV.
You need a Video Out port on the computer.
A TV is a lot lower resolution than a computer monitor.
Works for watching movies, but not text applications.
Text on the TV display will be fuzzy.
I have two computers here both with S Video ports.
I plan on getting a cable tomorrow and hooking one of them up.
See if I can watch movie files on the TV instead of the computer.
There is also a VGA converter you can use.
Also you can watch TV on a computer.
You just need a TV tuner card.
I do this now with my computer.
I can record stuff from my satelite box to my computer.
Using a TV as a computer monitor will work.
Just don't expect the same sharp picture you get with a monitor.
Pooh Bear
Just an update.....
I got an S Video cable today and hooked up the laptop to the TV.
Worked great for watching videos.
Couldn't hardly make out the text on the menues for the video player.
So, the TV is good for video, but not anything with text.
Pooh Bear
How close is the computer to the TV.
For short distances you can use an S video cable.
Limited to however long of cable you can get.
For longer distances you can use RCA Phono cables.
I have one RCA Phono video cable that is 20 feet long.
I don't know about longer distances.
I know you can get coax cables in very long lengths.
But the picture quality suffers horribly with these type cables.
You want to use the best cables you can get.
Check out SmartHome.com for in home video distribution hardware.
Pooh Bear
Here is a link that might be useful: Smart Home dot com
Dacor makes a kitchen media center. It has been on the market for about 2 years. The screen, speakers and controls mount under a cabinet. The screen flips up and out of sight when not in use, The capabilities are, tv, radio, internet and dvd. If you go to Dacor's website you can find it under "whats new". It is called the Kitchen Entertainment Center.
What about just using the PC as a combo TV and DVD player? We have DirecTV and Tivo and are thinking of getting a new, 3rd computer for one of the back bedrooms. The family member in that room does a lot of writing & research on the net via our wireless connection. He also watches a lot of DVD's from our large collection, and the occasional cable TV news program.
We want to dump the old Sony mega tv and huge stand that now take up most of the space in that tiny room (10x11 bedroom) and are thinking of getting one of the new HP multimedia PC's. If we do that, will we be able to run DirecTV through it? If so, how?
Thanks much.


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Those tips are also suitable for Kubuntu.
First of all,we need to add source for KDE4,as I guess most of sources you are using still haven't supplied KDE 4 packages.
sudo gedit /etc/apt/sources.list /* open sources.list file
then,to add below sources into you sources.list
deb http://ppa.launchpad.net/kubuntu-members-kde4/ubuntu gutsy main2
Save and exit.
Updating your sources by running: sudo aptitude update
Lastly,Intalling the KDE4 by running:sudo aptitude install kde4-core
NOTE:If you ever installed KDE4 before,you need to delete some files installing KDE4 in order to avoid confict before :
sudo aptitude remove kdelibs5 kde4base-data kde4libs-data3
Good luck


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Can this tile tile problem be fixed?
The tile setter configured a tile pattern on pony wall of shower. That pattern does not conform to the clean simple design I desired & what I'd expected based on pics on design websites (Houzz, etc). Pics from those websites show uninterrupted horizontal tile courses/grout lines from inside shower wall, across narrow front of pony wall, and around to outside of pony wall. After a couple sleepless nights trying to convince myself that this unconventional design would grow on me, I advised contractor that this chopped up vertical pattern was not acceptable & needed to be fixed. I think he plans to put 3x6 bullnose tiles, still in a vertical pattern, which will still break the horizontal continuum & leave an unbroken vertical line up the middle of the wall. IS THERE ABY WAY TO FIX THIS? is there a way to get the look wanted & what seems to be std in the industry, ie continuation of horizontal pattern across front of pony wall? Same pattern was used on shower ledge & top of wall. Any ideas on how to fix that?
I resubmitted Q w/ pic in later msg.
i did not give specific instructions about design, other than general design objective of clean & simple & that all work to be a/c to std in the trade. Remodel, materials, features & design are clean & simple except at end and top of pony wall & shower wall ledge. I assumed trade std was as seen in pics w/ pony wall or outside corners.
Fault or payment are not issue or Q. I just want to know how to fix it to make it look right, ie clean & simple. Tile in problem area is going to be torn out. My question is how are cont. horizontal tile lines accomplished when tiling around end of a pony wall.
I can't see the picture, but generally:
A consistent tile patter that wraps around corners and maintains a "grid" of tile uniform tile sizes requires a couple of things.
1) the tile in question generally has to come with trim pieces that are the same dimensions as the field tile. That means the bullnose pieces, the corner bullnose pieces, any cove pieces or inside or outside corner pieces all have to come in that size.
It's fairly standard to do 4x4 nominal tile with bullose and trim tile in 2x6, or 3x6 subway tile with bullnose and trim in 2x6, with corner bullnoses being as small as 2x2 nominal.
Unless you specify otherwise and special order (usually) the specific trim pieces it is common to use the other types of trim.
I am doing a bathroom right now that is going to be a perfect grid in all directions of full tile but it had to be planned that way in framing and we are still having to tweak it a bit.
Complicating it is that the company stopped making one crucial piece of trim because it was uncommonly requested.
But to get a ponywall to wrap in full tiles without pieces the finished ponywall needs to be the exact dimension for the tiles and this is not usually accomplished with 2x4 framing and drywall or cement board. The framing usually needs to be a bit smaller or larger to match up with tile dimensions.


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In a bid to revolutionise High Definition content in the Indian television market, Star India, the fully-owned subsidiary of global media firm News Corp, has re-launched five of its channels in HD.
The channels Star Plus, Star Movies, Star Gold, Star World and Nat Geo will be available in HD, which the company has termed as 'Asli HD.' "The launch of Asli HD today is a testimony of our commitment to offer our viewers world-class media experience. With Star's massively popular entertainment channels turning HD, a high definition revolution is set to kick-start in India. This is just a glimpse of a slew of exciting initiatives we will roll-out in the coming months," Star India CEO, Uday Shankar, told reporters on Friday.
Keywords: High Definition, television market, Star India


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H.Res.523 - Expressing the sense of the House of Representatives regarding the terrorist bombing of the United States Embassies in East Africa.105th Congress (1997-1998)
|Rep. Hastings, Alcee L. [D-FL-23] (Introduced 09/09/1998)
|House - International Relations
|Latest Action:
|10/10/1998 Motion to reconsider laid on the table Agreed to without objection.
This bill has the status Passed House
Here are the steps for Status of Legislation:
- Introduced
- Passed House
Subject — Policy Area:
- International Affairs
- View subjects
Summary: H.Res.523 — 105th Congress (1997-1998)All Bill Information (Except Text)
Shown Here:
Passed House amended (10/10/1998)
Expresses condolences to the families of all persons killed or injured in the terrorist bombings of the U.S. embassies in Kenya and Tanzania.
Expresses gratitude to: (1) U.S. Federal and local agencies, private organizations, and the people and the Governments of Kenya, Tanzania, Israel, France, the United Kingdom, Germany, Japan, Australia, and South Africa for their assistance in the aftermath of the bombings; (2) the U.S. embassy guards whose heroic actions prevented even more deaths and injuries; and (3) U.S. personnel for their dedication in serving abroad and assuming the risks of living and working overseas.
Expresses: (1) condemnation of all persons and parties involved in the bombings; (2) the determination of the House of Representatives to assist in the arrest of all persons responsible; and (3) the intention of the House to examine whether security needs of U.S. facilities overseas are being met and what kinds of tools can be employed to discourage nations from harboring terrorists.


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Think Voter Fraud Is a Joke? Think Again
Think Voter Fraud Is a Joke? Think Again
981 results for 'election'. Showing results 55 - 72
Think Voter Fraud Is a Joke? Think Again
Everthing You Need to Know about Midterm Elections
The Brody File dissects next week's big Midterm Election and the implications of what it all means. Plus, talking...
As seen on "The 700 Club," Oct. 29: Kurdish Peshmerga head to Syria to take on ISIS; Maynard stands...
Goodbye, Reid? Senate Could Hang on This One Race
Control of the Senate Coming Down to the Wire
Make or Break: The Fight for the Texas Latino Vote
Eyes on Fla., Iowa as Early Midterm Voting Begins
This week on The Brody File: The midterm elections are approaching and we're sitting down with two of Kansas'...
Election-Minded Dems Say 'No Thanks' to Obama
Low Voter Turnout Could Equal Big Trouble for Dems
Tight Kansas Race Could Decide Senate Power Shift
As seen on "The 700 Club," Oct. 6: CDC Director: 'We will stop Ebola in its tracks'; Is the...
Ayotte: Obama's Resolve on ISIS about Mid-Term Elections
WH Source: Obama's Known About ISIS Since 2012
China Says 'No' to Hong Kong Protesters' Demands
Hong Kong Protesters Defy Gov't, Call for Democracy
Hillary Clinton Stumps in Iowa, Sparks More 2016 Talk


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San Diego, CAUSA
November 25, 2013
I just love movies.
About us…
The San Diego Film & Art Cabal is a meetup for anyone that lives in the San Diego area, loves great film, art and other eclectic happenings and would like to get together with other film and art lovers for a movie or event. A community of urban dwellers joining each other in random cultural adventures. ;)
Besides signing up for any events already posted by myself or a co-host, members can also email me an event suggestion at any time. It could be an indie film playing Downtown, an art or theater event in Hilcrest, a comic book signing in North Park, a wine or beer tasting event in Little Italy, a lecture on army ants, performance art involving chickens and men dressed as wheelbarrows...high brow, low brow, no brow...all film and "art-related" event suggestions (in the focus area) are welcome!
(Focus area is currently Downtown, Little Italy, Hillcrest, North Park, South Park, Kensington, Mission Valley, University Heights, Normal Heights, UTC, La Jolla and Point Loma)
So if you have a suggestion...just throw it out there! Maybe you're not the only one who'd love to listen to an 8-hour lecture on the lack of aerodynamics in a platypus' bill...or view an art event focused solely on paintings made out of egg salad!
The San Diego Film & Art Cabal Facebook Page
(List, Reviews and Ratings)
Remaining films Robb wants to see in the theater in 2014
1,311 Discount Movie Fans
2,786 Entrepreneurs
2,972 Hikers
1,071 Art House Film Buffs
3,214 Business Networkers
769 Laugh Lovers
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


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"Blogger review"
While I got many good ideas from this, when the author starts reading long lists of "open bracket, underscore, close bracket, etc etc etc" I wanted to turn him off. Audible books are not the place to do this "programmerish junk". Better to name a blog to go to to see the typed words. The reader has a voice that has a strange accent (for lack of a better term) that really turned me off. Some subjects are better in hard copy than audible books.
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


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Sentence #77455
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text:
best small tree for zn 5
Hello, I am new to Gardenweb but already it seems to be a fantastic resource!! I have gardened for years but always at rental properties. I recently purchased my first home and am loving having complete garden freedom!!! I am looking for a small tree(30 ft or less ) to plant in my 6hr of sun, small backyard. I only have room for 1 tree so it has to be spectacular!!! Am looking for something with at least 3 season interest.
I have done some research and explored my local nurseries and so far I have come up with-japanese or korean stewartia, sourwood(some say questionable in zone 5), tri-color beech , heptacodium and 'oridono nishiki' japanese maple. Does anyone have any experience with any of these or any other suggestions? Help!! Thanks
Cornus kousa - Chinese Dogwood. Hardy in zone 5 and flowers longer and later than Cornus florida. It's bark is exfoliating with age. The ones by the woodworking building at the Erie County Fair in Hamburg exhibit this trait.
Mine set viable seed and was able to start new ones, thus saving a lot of $$$ - good for gifts for friends.
It has an vase shaped appearance in youth, older trees have a rounded shape. The ones at th Fairgrounds, unfortunately are sheared so they cannot exhibit natural growth habit :(
It is disease resistant and drought resistant, plus it will grow at a nice even pace - mine do.