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USDA Seeks 'Guidance Document' Concerning Organic Cows' Pasture Access
January 13, 2005 12:00 AM - Andrew Martin, Chicago Tribune
As more large dairies enter the robust organic milk business, the U.S. Department of Agriculture plans to clarify what it means to be an organic dairy cow.
Honda's President Details Initiatives in Hydrogen Fuel-Cell Engines
January 12, 2005 12:00 AM - Tom Matthews,The Columbus Dispatch, Ohio
Honda President Takeo Fukui laid out a vision for the company's future yesterday that was both clear and compact.
Device Could Cut Air Pollution at Long Beach, Calif., Port
January 12, 2005 12:00 AM - Eric Johnson, Press-Telegram, Long Beach, Calif.
Harbor Commissioners on Monday lauded the potential of new technology that may reduce
air pollution from giant ships docked at the Port of Long Beach by 90 percent or more.
Representatives of Oxnard-based Advanced Control Technology Inc. showed the commission details of the company's concept to capture diesel exhaust from ships by deploying a flexible hood over their smokestacks.
Graniteville, S.C., Mill Officials Fear Equipment Damage from Chlorine Leak
January 11, 2005 12:00 AM - Jim Nesbitt, The Augusta Chronicle, Ga.
Avondale Mills officials are still waiting to do a damage assessment of the seven plants and related offices shut down by the Norfolk Southern train wreck, but have been warned by chemical experts to expect massive damage from the corrosive chlorine leak that killed nine people, a company official said Monday.
GM's Fuel-Cell Cars Still Face Obstacles
January 10, 2005 12:00 AM - Jim Mateja, Chicago Tribune
General Motors Corp. says one problem has been solved, but two remain in making hydrogen-fuel-cell-powered vehicles viable by the automaker's 2010 target.
Silicon Valley Players Seek Breakthroughs in Alternative-Power Technology
January 9, 2005 12:00 AM - Matt Marshall, San Jose Mercury News, Calif.
Until recently, the energy business didn't hold much appeal for Silicon Valley entrepreneurs too old-world, too regulated, too, well, unenergetic.
Hull, Mass., Aims to Build High-Tech Water Desalination Plant
January 9, 2005 12:00 AM - Jenn Abelson, The Boston Globe
Hull officials are seeking proposals that would enable the town to draw its drinking water from the ocean and possibly build the nation's first wind-powered desalination plant.
3 Orangeburg, S.C.-Area Plants Release Cancer-Causing Pollutants
January 6, 2005 12:00 AM - The Times and Democrat, Orangeburg, S.C.
Three Times and Democrat Region industrial facilities ranked in the top 100 nationally for releases of cancer-causing pollutants for 2002, according to a report released Wednesday by the Environmental Defense agency.
Fort Worth, Texas, Approves Natural-Gas Drilling Under Parks
January 5, 2005 12:00 AM - Anna M. Tinsley, Fort Worth Star-Telegram, Ts
Drilling for natural gas could begin this summer under three city-owned parks under an agreement between the city and a Dallas-based oil and gas company.
Portland, Ore.-Based Crown Pacific's Creditors Take Over 522,000 Acres
January 5, 2005 12:00 AM - Jeff Manning, The Oregonian, Portland, Ore.
Crown Pacific Partners on Dec. 31 transferred 522,000 acres to a new company, Cascade Timberlands LLC, owned by Crown's major creditors.


text: Breast Cancer Research - Latest Articles http://breast-cancer-research.com/ The latest research articles published by Breast Cancer Research 2015-03-26T12:00:00Z Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF IntroductionHypercoagulability in malignancy is known to increase the risk of thrombosis, but is also involved in cancer progression. Experimental studies suggest that tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are involved in cancer biology as a tumor- promoter and suppressor, respectively, but the clinical significance is less clear. Here, we aimed to investigate the clinical relevance of TF and TFPI genetic and phenotypic diversity in breast cancer. Methods: The relationship between tumor messenger RNA (mRNA) expression and plasma levels of TF and TFPI (α and β), tagging single nucleotide polymorphisms (tagSNPs) in F3 (TF) (n = 6) and TFPI (n = 18), and clinicopathological characteristics and molecular tumor subtypes were explored in 152 treatment naive breast cancer patients. The effect of tumor expressed TF and TFPIα and TFPIβ on survival was investigated in a merged breast cancer dataset of 1881 patients. Results: Progesterone receptor negative patients had higher mRNA expression of total TFPI (α + β) (P = 0.021) and TFPIβ (P = 0.014) in tumors. TF mRNA expression was decreased in grade 3 tumors (P = 0.003). In plasma, total TFPI levels were decreased in patients with larger tumors (P = 0.013). SNP haplotypes of TFPI, but not TF, were associated with specific clinicopathological characteristics like tumor size (odds ratio (OR) 3.14, P = 0.004), triple negativity (OR 2.4, P = 0.004), lymph node spread (OR 3.34, P = 0.006), and basal-like (OR 2.3, P = 0.011) and luminal B (OR 3.5, P = 0.005) molecular tumor subtypes. Increased expression levels of TFPIα and TFPIβ in breast tumors were associated with better outcome in all tumor subtypes combined (P = 0.007 and P = 0.005) and in multiple subgroups, including lymph node positive subjects (P = 0.006 and P = 0.034). Conclusions: This study indicates that genetic and phenotypic variation of both TFPIα and TFPIβ, more than TF, are markers of cancer progression. Together with the previously demonstrated tumor suppressor effects of TFPI, the beneficial effect of tumor expressed TFPI on survival, renders TFPI as a potential anticancer agent, and the clinical significance of TFPI in cancer deserves further investigation. http://breast-cancer-research.com/content/17/1/44 Mari Tinholt Hans Vollan Kristine Sahlberg Sandra Jernström Fatemeh Kaveh Ole Lingjærde Rolf Kåresen Torill Sauer Vessela Kristensen Anne-Lise Børresen-Dale Per Sandset Nina Iversen Breast Cancer Research 2015, null:44 2015-03-26T12:00:00Z doi:10.1186/s13058-015-0548-5 /content/figures/s13058-015-0548-5-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 44 2015-03-26T12:00:00Z PDF Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response IntroductionTriple-negative (TN) breast cancers need to be refined in order to identify therapeutic subgroups of patients. Methods: We conducted an unsupervised analysis of microarray gene-expression profiles of 107 TN breast cancer patients and undertook robust functional annotation of the molecular entities found by means of numerous approaches including immunohistochemistry and gene-expression signatures. An 87 TN external cohort was used for validation. Results: Fuzzy clustering separated TN tumours into three clusters: C1 (22.4%), C2 (44.9%) and C3 (32.7%). C1 patients were older (mean = 64.6 years) than C2 (mean = 56.8 years; P = 0.03) and C3 patients (mean = 51.9 years; P = 0.0004). Histological grade and Nottingham prognostic index were higher in C2 and C3 than in C1 (P < 0.0001 for both comparisons). Significant event-free survival (EFS) (P = 0.03) was found according to cluster membership: patients belonging to C3 had a better outcome than patients in C1 (P = 0.01) and C2 (P = 0.02). EFS analysis results were confirmed when our cohort was pooled with external cohort (n = 194; P = 0.01). Functional annotation showed that 22% of TN patients were not basal-like (C1). C1 was enriched in luminal subtypes and positive androgen receptor (luminal androgen receptor [LAR]). C2 could be considered as an almost pure basal-like cluster. C3, enriched in basal-like subtypes, but to a lesser extent, included 26% of claudin-low subtypes. Dissection of immune response showed that high immune response (HIR) and low M2-like macrophages were a hallmark of C3, and that these patients had a better EFS than C2 patients, characterized by low immune response (LIR) and high M2-like macrophages: P = 0.02 for our cohort, and P = 0.03 for pooled cohorts. Conclusions: We identified 3 subtypes of TN patients: LAR (22%), basal-like with LIR and high M2-like macrophages (45%) and basal-enriched with HIR and low M2-like macrophages (33%). We pointed out that macrophages and other immune effectors offer a variety of therapeutic targets in breast cancer, and particularly in TN basal-like tumours. Furthermore, we showed that CK5 antibody was better suited than CK5/6 antibody to subtype TN patients. http://breast-cancer-research.com/content/17/1/43 Pascal Jézéquel Delphine Loussouarn Catherine Guérin-Charbonnel Loïc Campion Antoine Vanier Wilfried Gouraud Hamza Lasla Catherine Guette Isabelle Valo Véronique Verrièle Mario Campone Breast Cancer Research 2015, null:43 2015-03-20T12:00:00Z doi:10.1186/s13058-015-0550-y /content/figures/s13058-015-0550-y-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 43 2015-03-20T12:00:00Z PDF Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a pre-clinical model IntroductionInflammatory breast cancer (IBC) is an aggressive type of breast cancer, characterized by very rapid progression, enlargement of the breast, skin edema causing an orange peel appearance (peau d'orange), erythema, thickening, and dermal lymphatic invasion. It is characterized by E-cadherin overexpression in the primary and metastatic disease, but to date no robust molecular features that specifically identify IBC have been reported. Further, models that recapitulate all of these clinical findings are limited and as a result no studies have demonstrated modulation of these clinical features as opposed to simply tumor cell growth. Methods: Hypothesizing the clinical presentation of IBC may be mediated in part by the microenvironment, we examined the effect of co-injection of IBC xenografts with mesenchymal stem/stromal cells (MSCs). Results: MSCs co-injection significantly increased the clinical features of skin invasion and metastasis in the SUM149 xenograft model. Primary tumors co-injected with MSCs expressed higher phospho-Epidermal growth factor receptor (p-EGFR) and promoted metastasis development after tumor resection, effects that were abrogated by treatment with the Epidermal growth factor receptor (EGFR) inhibitor, Erlotinib. E-cadherin expression was maintained in primary tumor xenografts with MSCs co-injection compared to control and Erlotinib treatment dramatically decreased this expression in control and MSCs co-injected tumors. Tumor samples from patients demonstrate correlation between stromal and tumor p-EGFR staining only in IBC tumors. Conclusions: Our findings demonstrate that the IBC clinical phenotype is promoted by signaling from the microenvironment perhaps in addition to tumor cell drivers. http://breast-cancer-research.com/content/17/1/42 Lara Lacerda Bisrat Debeb Daniel Smith Richard Larson Travis Solley Wei Xu Savitri Krishnamurthy Yun Gong Lawrence Levy Thomas Buchholz Naoto Ueno Ann Klopp Wendy Woodward Breast Cancer Research 2015, null:42 2015-03-20T12:00:00Z doi:10.1186/s13058-015-0549-4 /content/figures/s13058-015-0549-4-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 42 2015-03-20T12:00:00Z PDF Quantitative measurement of HER2 expression in breast cancers: comparison with "real world" routine HER2 testing in a multi-center Collaborative Biomarker Study and correlation with overall survival IntroductionAccurate assessment of HER2 status is critical in determining appropriate therapy for breast cancer patients but the best HER2 testing methodology has yet to be defined. In this study, we compared quantitative HER2 expression by the HERmark® Breast Cancer Assay (HERmark) with routine HER2 testing by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and correlated HER2 results with overall survival (OS) of breast cancer patients in a multi-center Collaborative Biomarker Study (CBS). Methods: 232 formalin-fixed, paraffin-embedded breast cancer tissues and local laboratory HER2 testing results were provided by 11 CBS sites. HERmark assay and central laboratory HER2 IHC re-testing were retrospectively performed in a blinded fashion. HER2 results by all testing methods were obtained in 192 cases. Results: HERmark yielded a continuum of total HER2 expression (H2T) ranging from 0.3 to 403 RF/mm2 (~3 logs). The distribution of H2T levels correlated significantly (p < 0.0001) with all routine HER2 testing results. The concordance of positive and negative values (equivocal cases excluded) between HERmark and routine HER2 testing was 84% for local IHC, 96% for central IHC, 85% for local FISH, and 84% for local HER2 status. OS analysis revealed a significant correlation of shorter OS with HER2 positivity by local IHC (HR = 2.6, P = 0.016), central IHC (HR = 3.2, P = 0.015), and HERmark (HR = 5.1, P < 0.0001) in this cohort of patients most of whom received no HER2 targeted therapy. The OS curve of discordant low (HER2 positive but H2T low, 10% of all cases) was aligned with concordant negative (HER2 negative and H2T low, HR = 1.9, P = 0.444), but showed a significantly longer OS than concordant positive (HER2 positive and H2T high, HR = 0.31, P = 0.024). Conversely, the OS curve of discordant high (HER2 negative but H2T high, 9% of all cases) was aligned with concordant positive (HR = 0.41, P = 0.105), but showed a significantly shorter OS than concordant negative (HR = 41, P < 0.0001). Conclusions: Quantitative HER2 measurement by HERmark is highly sensitive, accurately quantifies HER2 protein expression and correlates well with routine HER2 testing. When HERmark and local HER2 results were discordant, HERmark more accurately predicted overall survival. http://breast-cancer-research.com/content/17/1/41 Denise Yardley Peter Kaufman Weidong Huang Lea Krekow Michael Savin William Lawler Stephen Zrada Alexander Starr Harvey Einhorn Lee Schwartzberg John Adams Yolanda Lie Agnes Paquet Jeff Sperinde Mojgan Haddad Steve Anderson Marlon Brigino Rick Pesano Michael Bates Jodi Weidler Linda Bosserman Breast Cancer Research 2015, null:41 2015-03-18T00:00:00Z doi:10.1186/s13058-015-0543-x /content/figures/s13058-015-0543-x-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 41 2015-03-18T00:00:00Z PDF Mechanisms of endocrine resistance in breast cancer: an overview of the proposed roles of noncoding RNA Endocrine therapies such as tamoxifen and aromatase inhibitors are the standard treatment options for estrogen receptor-positive breast cancer patients. However, resistance to these agents has become a major clinical obstacle. Potential mechanisms of resistance to endocrine therapies have been identified, often involving enhanced growth factor signaling and changes in the expression or action of the estrogen receptor, but few studies have addressed the role of noncoding RNA (ncRNA). Two important types of ncRNA include microRNA (miRNA) and long noncoding RNA (lncRNA). miRNAs are small RNA molecules that regulate gene expression via translational inhibition or degradation of mRNA transcripts, while lncRNAs are larger RNA molecules that have been shown to play a role in multiple cellular maintenance functions such as protein scaffolding, chromatin looping, and regulation of mRNA stability. Both miRNA and lncRNA have recently impacted the field of breast cancer research as important pieces in the mechanistic puzzle of the genes and pathways involved in breast cancer development and progression. This review serves as an overview of the roles of miRNA and lncRNA in breast cancer progression and the development of endocrine resistance. Ideally, future experiments in the field should include identification of ncRNAs that could be potential therapeutic targets in endocrine-resistant tumors, as well as ncRNA biomarkers that facilitate more tumor-specific treatment options for endocrine-resistant breast cancer patients. http://breast-cancer-research.com/content/17/1/40 Erin Hayes Joan Lewis-Wambi Breast Cancer Research 2015, null:40 2015-03-17T12:00:00Z doi:10.1186/s13058-015-0542-y /content/figures/s13058-015-0542-y-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 40 2015-03-17T12:00:00Z XML Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N prospective cohort IntroductionDioxins are environmental and persistent pollutants mostly emitted from combustion facilities (e.g. waste incinerators, metal and cement industries). Known to be endocrine disrupting chemicals, dioxins are suspected to increase breast cancer (BC) risk. Although diet is considered the primary source of dioxin exposure, no previous study has been published on dietary dioxin exposure in relation to BC risk. We aimed to assess dietary dioxin exposure among women from the E3N cohort and estimate BC risk associated with this exposure. Methods: The study included 63,830 women from the E3N cohort who completed a diet history questionnaire (DHQ) in 1993 and were followed until 2008. Dietary dioxin exposure was estimated by combining consumption data from the E3N DHQ and food dioxin contamination data from a French national monitoring program. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox models adjusted for BC risk factors. Results: Mean dietary dioxin exposure was estimated at 1.3 ± 0.4 pg/kg body weight (BW)/day. A 0.4 pg/kg BW/d increase in dioxin intake was not associated with overall BC risk (HR = 1.00; 95% CI: 0.96, 1.05). A significant decrease in risk of estrogen receptor negative (ER-)/progesterone receptor negative (PR-) tumors was observed among post-menopausal women in the upper quartile of estimated dioxin intake (HR for Q4 vs. Q1: 0.65; 95% CI: 0.45, 0.96; P for trend across quartiles = 0.0463). Conclusions: Overall, no association between estimated dietary dioxin exposure and BC risk was found among E3N women. Further studies should include both dietary and environmental exposures to determine whether low-dose dioxin exposure is associated with BC risk. http://breast-cancer-research.com/content/17/1/39 Aurélie Danjou Béatrice Fervers Marie-Christine Boutron-Ruault Thierry Philip Françoise Clavel-Chapelon Laure Dossus Breast Cancer Research 2015, null:39 2015-03-17T00:00:00Z doi:10.1186/s13058-015-0536-9 Dietary dioxins not linked to increased breast cancer risk Despite concerns to the contrary, a large study of women in France finds that exposure to dioxins through dietary intake is not associated with an increased risk of breast cancer. /content/figures/s13058-015-0536-9-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 39 2015-03-17T00:00:00Z XML Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice IntroductionMatrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor types. Methods: We have intercrossed Mmp8-null mice with the Polyoma virus middle T oncogene-driven (MMTV-PyMT) mouse model of mammary cancer to explore the effects of loss of MMP-8 on the incidence and progression of mammary carcinomas. Results: In this aggressive mouse model of breast cancer, loss of MMP-8 accelerated tumor onset even further, such that 90% of MMTV-PyMT; Mmp8-null female mice were tumor-bearing at the time of weaning. Throughout the 14 weeks of the model, tumor burden increased in homozygous Mmp8-null mice compared to Mmp8 wild-type and heterozygote animals. Likewise, lung metastasis dramatically increased in the MMTV-PyMT; Mmp8-null mice. Immunohistochemistry revealed that tumors in wild-type, Mmp8-heterozygotes and -null animals had similar vascular density at 8 weeks, but at 10 weeks Mmp8-wild-type tumors had a lower vascularity than their heterozygote and null counterparts. No differences in macrophage infiltration were apparent throughout primary tumor development, though at 10 weeks a drop in neutrophil infiltrates was observed in Mmp8-wild-type tumors. Using quantitative real-time RT-PCR, we tracked the expression of the entire Mmp and Timp gene families, observing a significant decrease in Mmp3 expression in Mmp8-null tumors compared to wild-type and heterozygotes throughout the timecourse of the model, which was confirmed at the protein level. Conclusions: These findings provide novel insight into the suppressive action of MMP-8 on mammary tumorigenesis and metastasis, and indicate that the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web. http://breast-cancer-research.com/content/17/1/38 Julie Decock Wouter Hendrickx Sally Thirkettle Ana Gutiérrez-Fernández Stephen Robinson Dylan Edwards Breast Cancer Research 2015, null:38 2015-03-14T00:00:00Z doi:10.1186/s13058-015-0545-8 /content/figures/s13058-015-0545-8-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 38 2015-03-14T00:00:00Z PDF Lobular breast cancer: incidence and genetic and non-genetic risk factors While most invasive breast cancers consist of carcinomas of the ductal type, about 10% are invasive lobular carcinomas. Invasive lobular and ductal carcinomas differ with respect to risk factors. Invasive lobular carcinoma is more strongly associated with exposure to female hormones, and therefore its incidence is more subject to variation. This is illustrated by US figures during the 1987 to 2004 period: after 12 years of increases, breast cancer incidence declined steadily from 1999 to 2004, reflecting among other causes the decreasing use of menopausal hormone therapy, and these variations were stronger for invasive lobular than for invasive ductal carcinoma. Similarly, invasive lobular carcinoma is more strongly associated with early menarche, late menopause and late age at first birth. As for genetic risk factors, four high-penetrance genes are tested in clinical practice when genetic susceptibility to breast cancer is suspected, BRCA1, BRCA2, TP53 and CDH1. Germline mutations in BRCA1 and TP53 are predominantly associated with invasive ductal carcinoma, while BRCA2 mutations are associated with both ductal and lobular cancers. CDH1, the gene coding for the E-cadherin adhesion protein, is of special interest as mutations are associated with invasive lobular carcinoma, but never with ductal carcinoma. It was initially known as the main susceptibility gene for gastric cancer of the diffuse type, but the excess of breast cancers of the lobular type in CDH1 families led researchers to identify it also as a susceptibility gene for invasive lobular carcinoma. The risk of invasive lobular carcinoma is high in female mutation carriers, as about 50% are expected to develop the disease. Carriers must therefore undergo intensive breast cancer screening, with, for example, yearly magnetic resonance imaging and mammogram starting at age 30 years. http://breast-cancer-research.com/content/17/1/37 Laure Dossus Patrick Benusiglio Breast Cancer Research 2015, null:37 2015-03-13T00:00:00Z doi:10.1186/s13058-015-0546-7 /content/figures/s13058-015-0546-7-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 37 2015-03-13T00:00:00Z XML Lectin RCA-I specifically binds to metastasis-associated cell surface glycans in triple negative breast cancer IntroductionTriple-negative breast cancer (TNBC) patients often face a high risk of early relapse characterized by extensive metastasis. Previous works have shown that aberrant cell surface glycosylation is associated with cancer metastasis, suggesting that altered glycosylations might serve as diagnostic signatures of metastatic potential. To address this question, we took TNBC as an example and analyzed six TNBC cell lines, derived from a common progenitor, that differ in metastatic potential. Methods: We used a microarray with 91 lectins to screen for altered lectin bindings to the six TNBC cell lines. Candidate lectins were then verified by lectin-based flow cytometry and immunofluorescent staining assays using both TNBC/non-TNBC cancer cells. Patient-derived tissue microarrays were then employed to analyze whether the staining of Ricinus Communis agglutinin I (RCA-I), correlated with TNBC severity. We also carried out real-time cell motility assays in the presence of RCA-I. Finally, liquid chromatography-mass spectrometry/tandem spectrometry (LC-MS/MS) was employed to identify the membrane glycoproteins recognized by RCA-I. Results: Using the lectin microarray, we found that the bindings of RCA-I to TNBC cells are proportional to their metastatic capacity. Tissue microarray experiments showed that the intensity of RCA-I staining is positively correlated with the TNM grades. The real-time cell motility assays clearly demonstrated RCA-I inhibition of adhesion, migration, and invasion of TNBC cells of high metastatic capacity. Additionally, a membrane glycoprotein, POTE ankyrin domain family member F (POTEF), with different galactosylation extents in high/low metastatic TNBC cells was identified by LC-MS/MS as a binder of RCA-I. Conclusions: We discovered RCA-I, that bound to TNBC cells to a degree that is proportional to their metastatic capacities, found that this binding inhibits the cell invasion, migration, and adhesion, and identified a membrane protein, POTEF, that may play a key role in mediating these effects. These results thus indicate that RCA-I specific cell surface glycoproteins may play a critical role in TNBC metastasis and that the extent of RCA-I cell binding could be used in diagnosis to predict the likelihood of developing metastases in TNBC patients. http://breast-cancer-research.com/content/17/1/36 Shu-Min Zhou Li Cheng Shu-Juan Guo Yang Wang Daniel Czajkowsky Huafang Gao Xiao-Fang Hu Sheng-Ce Tao Breast Cancer Research 2015, null:36 2015-03-11T00:00:00Z doi:10.1186/s13058-015-0544-9 /content/figures/s13058-015-0544-9-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 36 2015-03-11T00:00:00Z PDF Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer IntroductionAromatase inhibitors (AIs) are a vital component of estrogen receptor positive (ER+) breast cancer treatment. De novo and acquired resistance, however, is common. The aims of this study were to relate patterns of copy number aberrations to molecular and proliferative response to AIs, to study differences in the patterns of copy number aberrations between breast cancer samples pre- and post-AI neoadjuvant therapy, and to identify putative biomarkers for resistance to neoadjuvant AI therapy using an integrative analysis approach. Methods: Samples from 84 patients derived from two neoadjuvant AI therapy trials were subjected to copy number profiling by microarray-based comparative genomic hybridisation (aCGH, n = 84), gene expression profiling (n = 47), matched pre- and post-AI aCGH (n = 19 pairs) and Ki67-based AI-response analysis (n = 39). Results: Integrative analysis of these datasets identified a set of nine genes that, when amplified, were associated with a poor response to AIs, and were significantly overexpressed when amplified, including CHKA, LRP5 and SAPS3. Functional validation in vitro, using cell lines with and without amplification of these genes (SUM44, MDA-MB134-VI, T47D and MCF7) and a model of acquired AI-resistance (MCF7-LTED) identified CHKA as a gene that when amplified modulates estrogen receptor (ER)-driven proliferation, ER/estrogen response element (ERE) transactivation, expression of ER-regulated genes and phosphorylation of V-AKT murine thymoma viral oncogene homolog 1 (AKT1). Conclusions: These data provide a rationale for investigation of the role of CHKA in further models of de novo and acquired resistance to AIs, and provide proof of concept that integrative genomic analyses can identify biologically relevant modulators of AI response. http://breast-cancer-research.com/content/17/1/35 Elena López-Knowles Paul Wilkerson Ricardo Ribas Helen Anderson Alan Mackay Zara Ghazoui Aradhana Rani Peter Osin Ash Nerurkar Lorna Renshaw Alexey Larionov William Miller J Dixon Jorge Reis-Filho Anita Dunbier Lesley-Ann Martin Mitch Dowsett Breast Cancer Research 2015, null:35 2015-03-11T00:00:00Z doi:10.1186/s13058-015-0532-0 /content/figures/s13058-015-0532-0-toc.gif Breast Cancer Research 1465-5411 ${item.volume} 35 2015-03-11T00:00:00Z PDF

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Research Article
The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH
Article first published online: 2 JUL 2012
DOI: 10.1002/rcm.6282
Copyright © 2012 John Wiley & Sons, Ltd.
Rapid Communications in Mass Spectrometry
Volume 26, Issue 16, pages 1783–1792, 30 August 2012
Additional Information
How to Cite
Hodkinson, J. P., Radford, S. E. and Ashcroft, A. E. (2012), The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH. Rapid Commun. Mass Spectrom., 26: 1783–1792. doi: 10.1002/rcm.6282
Publication History
- Issue published online: 2 JUL 2012
- Article first published online: 2 JUL 2012
- Manuscript Revised: 15 MAY 2012
- Manuscript Accepted: 15 MAY 2012
- Manuscript Received: 16 APR 2012
- Abstract
- Article
- References
- Cited By
Amyloid formation is implicated in a number of human diseases. β2-microglobulin (β2m) is the precursor protein in dialysis-related amyloidosis and it has been shown that partial, or more complete, unfolding is key to amyloid fibril formation in this pathology. Here the relationship between conformational flexibility and β2m amyloid formation at physiological pH has been investigated.
HDX-ESI-MS was used to study the conformational dynamics of β2m. Protein engineering, or the addition of Cu2+ ions, sodium dodecyl sulphate, trifluoroethanol, heparin, or protein stabilisers, was employed to perturb the conformational dynamics of β2m. The fibril-forming propensities of the protein variants and the wild-type protein in the presence of additives, which resulted in >5-fold increase in the EX1 rate of HDX, were investigated further.
ESI-MS revealed that HDX occurs via a mixed EX1/EX2 mechanism under all conditions. Urea denaturation and tryptophan fluorescence indicated that EX1 exchange occurred from a globally unfolded state in wild-type β2m. Although >30-fold increase in the HDX exchange rate was observed both for the protein variants and for the wild-type protein in the presence of specific additives, large increases in exchange rate did not necessarily result in extensive de novo fibril formation.
The conformational dynamics measured by the EX1 rate of HDX do not predict the ability of β2m to form amyloid fibrils de novo at neutral pH. This suggests that the formation of amyloid fibrils from β2m at neutral pH is dependent on the generation of one or more specific aggregation-competent species which facilitate self-assembly. Copyright © 2012 John Wiley & Sons, Ltd.


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North Dakota man found guilty of murder
JAMESTOWN (AP) -- A North Dakota man who admitted he hit an 18-year-old Somali man whose dead body was found in a ditch was found guilty of murder and criminal conspiracy Thursday.
A jury of eight women and four men deliberated for a day and half before finding Leron Howard, 35, guilty of the charges in the April 2011 killing of Abdi Ali Ahmed, 18.
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Stayed here for one night as the place you crash into right off the ferry. They gave us a small discount which was nice.
We got the room on the ship (they have something that looks like a ship as part of the hotel).
The room had a weird smell. The bathroom walls did not go all the way up to the ceiling so it didn't feel very private.
The breakfast was below average.
I would not stay here if I could avoid it :)
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How long does it take bamboo to offgass?
melaromaFebruary 10, 2012
We are thinking of installing bamboo floors in the future nursery room. We are hoping to get it installed sometime next month with the plan of trying to starting a family this summer. I'm wondering how long it would take the bamboo floor to offgass as I don't want to be around toxins if I can avoid them once I am pregnant.
Also, are there any other hard wood floor that anyone would recommend to be less toxic? We currently have shaggy orange 70's carpet in there that is disgusting and has to go but I hear that new carpet would be more toxic so we are looking at wood. Any ideas would be appreciated.


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Shamrock Series to Indy in '14
Notre Dame's next Shamrock Series game will take place in Indianapolis against a familiar opponent: Purdue.
The Sept. 13, 2014, matchup is set for 7:30 p.m. ET at Lucas Oil Stadium. In addition, the in-state rivals have added future matchups as the series will resume in 2020.
"We are excited to bring this great instate rivalry game to Indianapolis next season," Purdue athletic director Morgan Burke said in a statement. "Both schools have great fan and alumni bases there, so it will make for an entertaining evening of college football."
It was also announced Thursday that the Boilermakers will play a home-and-home series with Virginia Tech in 2015 (West Lafayette) and 2023 (Blacksburg, Va.).
The game against Notre Dame was originally slated for South Bend, Ind. Purdue will now have access to "some 10,000 seats -- twice the normal visiting-school allotment," per the release.
The Fighting Irish have played the Shamrock Series contest in each of the past five years, moving a home game to a major metropolitan area. They have traveled to San Antonio, New York, the Washington, D.C., region, Chicago and the Dallas area. They have unveiled innovative uniform combinations for each of those games as well.
More from ESPN.com
How did Michigan respond to the end of its series with Notre Dame? By adding Florida, a signal of intent by the Wolverines, writes Adam Rittenberg. Story
Notre Dame and Purdue also said they've added games in 2020 and 2021 and 2024 to 2026. The schools, with campuses 110 miles apart, have played every year since 1946 and 85 times overall.
The 2014 game had been the last on the rivals' current contract. Notre Dame has had to make cuts to its Big Ten matchups since announcing it'll play five ACC games a year starting in 2014. The Big Ten is also moving to a nine-game conference schedule in 2016, further complicating matters.
Michigan is the most notable cut, as the 2014 meeting is the final scheduled matchup between the two.
Information from The Associated Press was used in this report.
Matt Fortuna | emailCollege Football
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- Joined ESPN.com in 2011
- Graduate of Penn State University
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No. 1 Florida State and No. 2 Auburn will play in the VIZIO BCS National Championship at Rose Bowl Stadium. Coverage »
- Why Johnson Is Right
- Expect new CFB Playoff Committee member Bobby Johnson to fit right in.
Low »
- Less Money, More Problems?
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- The Perks Of Being A Coach
- Incentives written into contracts can mean millions more.
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- Betting: Best 2015 CFB Playoff bets
- Katz: Teams that will surprise in 2015
- Haney: TCU among 2015 favorites
- National links: Reshuffling the top four


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Our Customers Say:
It was the trip of a lifetime and the tickets were awesome. The seats were even better than you had promised. Thank you so much!
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the whole plan isnt dying on this one it's just the under part.
Yeah, kind of the same as the other one. They will wilt from the bottom up. Assuming that they are getting enough water, I would remove the affected leaves and spray with your fungicide of choice. I use Daconil.


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|Apr 01 04:31 GMT
Forex Expos
Fundamental Analysis Reports
Q1 WRAP: Race To The Bottom Appears Far From Over
Apr 01 02:18 GMT, by
Q1 has seen Central Banks the world over reduce interest rates in a 'race to the bottom'. USD Continues it most bullish rally in decades as the markets anticipate a miniscule rate increase by FED. St...
Market Mythbusting: The 'Strong' Correlation Between USD And US Stocks
Apr 01 01:48 GMT, by
In many regards, it seems like some traders think they have their own version of magical shoes: as long as they repeat a mantra enough times, it will become true. One dubious trading theory that is c...
EM Rundown: TRYing To Get The Lights Back On In Turkey
Apr 01 01:44 GMT, by
It's been a relatively quiet start to what could be a very interesting week in the FX market. While many traders are already looking ahead to a long holiday weekend, there is one big fly in the Easte...
Buffet, Grexit And The Aussie
Apr 01 01:40 GMT, by
Similarly, the market really is sick of reading the same headlines around Greece, but like the name Warren Buffet, it keeps us clicking. It's gotten to the point where they are treated as entertainme...
US Consumer Confidence Rebounds in March
Mar 31 15:25 GMT, by
The Conference Board's measure of US consumer confidence rose by 2.5 points to 101.3 in March 2015, partially retracing a revised 5.0 point decline to 98.8 in February (previously reported as 96.4). ...
Canadian January GDP Drops in the MonthAll Daily Fundamental Reports >>
Mar 31 15:23 GMT, by
January 2015 GDP dropped by 0.1% in the month, which only partially retraced the unrevised 0.3% gain in December 2014. Market expectations had been for a slightly larger 0.2% drop in the month. Ex...
Technical Analysis Reports
AUDUSD Bounces Higher On Mild China PMI Expansion
Apr 01 02:19 GMT, by
The Aussie has depreciated over 4% since 24th March and looks set to challenge the 0.756 lows over the coming sessions. Today's data saw bulish traders buck the trend to drive the Aussie up to 0.7665...
AUD/USD – Hoping For Support At 0.7550
Apr 01 02:14 GMT, by
For the last week or so now the Australian dollar has fallen away sharply to down below the key 0.77 level and further to some short term support around 0.76. Its next obvious support level is down a...
Australia 200 – Looking For Ongoing Support From Key 5800 Level
Apr 01 02:13 GMT, by
A couple of weeks ago the Australia 200 index pushed higher to a multi-year high to just above the key resistance level at 6000, before easing lower throughout last week to below 5900. It now has its...
EURJPY: Supporting The Cause
Apr 01 01:50 GMT, by
The North American trading day ended on a sour note as US equities attempted to climb in to the green in the second half of trade, but fell faster toward the end of the day than at any other time. Th...
AUDNZD: ABC Parity?
Apr 01 01:45 GMT, by
The first half of North American trade has been a mixed bag of tricks for traders so far as usual correlations aren't behaving so well. While the EUR/USD has fallen lower on renewed concerns about Gr...
Forex Technical AnalysisAll Daily Technical Reports >>
Mar 31 11:19 GMT, by
The uptrend is still intact, currently testing 120.40 resistance area. Initial support lies at 119.50 and an eventual violation of 120.40 resistance will challenge 121.20 area.
Analysis Report Search
Long Term Forecasts
Euro Area Outlook for 2015: Impact of Broad-Based QE
Jan 17 03:46 GMT, by
The expected ECB QE programme will support economic activity through a number of channels and hence...
When Will the Bank of England Hike Rates?
Aug 16 08:33 GMT, by
In the first report of a two-part series on the outlook for Bank of England (BoE) monetary policy, ...
Growth in China Appears to Be Stabilizing
Jul 19 08:05 GMT, by
The year-over-year rate of real GDP growth in China edged up to 7.5 percent in Q2 from 7.4 percent ...
FX Forecast Update: Negative Rates and Liquidity Tools to Weaken the Euro
Jun 14 03:24 GMT, by
The ECB delivered more easing than expected at its rate meeting in June by cutting both the refi an...
AUD/USD - 2013 In ReviewAll Long Term Forecasts >>
Jan 02 02:25 GMT, by
The Australian dollar is known for its strong volatility, and taking traders on roller coaster ride...
|ActionForex.com © 2015 All rights reserved.


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The Wonderful Desi Butts
The butts of of desi girls are equally famous as their name. The speciality of desi is that they are a little towards chubbiness and the butt shows well. With a good walking style it shows much more well. A Nayantara, an Asin, a meera jasmine would look better with the same butt as that of a non-native because they know how to use it.
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Dickinson man gets 7½ years for Medina bank robbery
Dickinson man Satrone Rashard Boyd, 38, was sentenced Wednesday to 7½ years in prison for robbing a small town North Dakota bank.
Boyd and co-defendant Rendell Charles Hardy, also of Dickinson, "forcefully robbed" Medina's Northland Financial bank the morning of Oct. 25, according to a press release from U.S. Attorney Tim Purdon's office.
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It's that time of year again, and naturally, we have the requisite holiday-themed posts. Many of them elicit their share of groans and rolled eyes, from yours truly included. But we thought we'd have at least a little fun with this one. Listed below are our five naughtiest and five nicest trucks and SUVs. There will be some overlap, as the criteria for naughty and nice are not exactly the same.
"Naughty" Criteria: Fastest Acceleration, Most Aggressive Styling, or other traits that could be perceived as anti-social by the Prius-driving enlightened elites.
"Nice" Criteria: By highest manufacturer's suggested retail price, most lavish accommodations, or highest fuel economy.
In the broader definition of "naughty" and "nice" these definitions make sense, but instead of splitting hairs any longer, here are our naughty and nice list picks:
Naughty: BMW X6 M
Why is the X6 M on our naughty list? Quite simply, because nobody "needs" a 555-hp four-passenger SUV that costs $94,825. We would have picked the X5 M, since it makes marginally more sense than its fastback sibling, but the model has been discontinued for 2014, leaving only the hottest version of BMW's "sport activity coupe." It's fuel economy ratings of 13 city and 17 highway don't help much to tip the scales in the "nice" direction, either.
Naughty: Ford F-150 SVT Raptor
The Raptor may not be the fastest, most powerful, or most expensive truck on the market, but it's definitely one of the most head-turning, getting as much attention in New York's midtown Manhattan as Manhattan, Kansas. The bold styling transforms the F-150 from an everyday hauler to an attitude-packed beast, and the aftermarket has come up with plenty of personalization and performance options to raise the bar even further. The best part is all this fun is attainable for a relatively reasonable $45,610, assuming you can find one that doesn't have a $15,000 dealer markup.
Nice: Jeep Grand Cherokee EcoDiesel
The VM Motori 3.0-liter V-6 turbodiesel makes an encore appearance on the Nice list for its application in the 2014 Jeep Grand Cherokee. In two-wheel-drive form, the Jeep gets 30 mpg highway with the engine, a laudable accomplishment in an SUV weighing more than 5000 pounds. On a cross-country road trip, we saw a highway figure of greater than 30 mpg on several legs. But in addition to being notably frugal for an SUV, in Summit trim, the Grand Cherokee approaches the luxury level of models costing tens of thousands more from "status" brands.
Naughty: Jeep Grand Cherokee SRT
If you crave Cayenne-level performance, but can't justify paying six figures, the Jeep Grand Cherokee SRT gives you 90 percent of the performance of the Porsche for less than half the price. Even fully equipped, the Grand SRT barely crests $70,000. While that's a lot of scratch for a Jeep, and actually makes it the second-most expensive vehicle in Chrysler's corporate portfolio after the Viper, the take-no-prisoners performance of the 470-hp Hemi V-8 and the ample comfort and convenience features don't make you feel sore after writing the check for it.
Nice: Land Rover Range Rover Autobiography
The Range Rover may conjure up images of Her Majesty touring her country estate or, for us more gauche colonists, the Kardashians driving to yet another one of their insipid wastes of reality video footage, but there's no denying the luxury and presence of a Range Rover. That bar has been set even higher for 2014 with the ultra-limited edition Range Rover Autobiography long-wheelbase. The non-Autobiography LWB model starts at "just" $106,195, with the most-exclusive limited edition Autobiography Black with (ironically) Valloire White paint going for just a whiff under $200,000 at $199,500.
Naughty: Mercedes-Benz G63 AMG 6x6
Where else would you put a 9000-pound, six-wheel-drive Mercedes SUV with a fording depth of more than 3-feet and a $500,000+ price tag? Sure, with an estimated 0-60 time of 8 seconds, it's not going to set any speed or acceleration records. But with this much bulk and attitude, you can run right over those records. Unfortunately, this six-wheeled beast isn't certified for U.S. roads, but if you live in Dubai or Dusseldorf, this is the ultimate expression of off-road swagger.
Nice: Mercedes-Benz GL 350 Bluetec
Once more, a diesel SUV makes our Nice list for its sumptuous appointments as well as its impressive fuel economy. Although the GL350 Bluetec hypothetically starts at $63,305, our tester had more than $25,000 in options on it, bringing the total to $88,615. Nice indeed. Its 19 city, 26 highway EPA rating, combined with a 26.4-gallon tank make for a long-legged cruising range of 686 miles or from Los Angeles to Las Vegas and back on one tank, with more than 100 miles to spare.
Naughty: Porsche Cayenne S Turbo
There's plenty "nice" about a Porsche Cayenne, but when you're talking about the Turbo S model, you're definitely taking a ride on the naughty side. With 550 hp, a 0-60 time of just 4.3 seconds, and a top speed of 175 mph, this Cayenne lives up to the performance promised by its spicy name. For that level of power and performance in an SUV, the fuel economy figures of 14 city and 20 highway aren't all that bad. But if you want the privilege of parking a Turbo S in your garage, be prepared to pay up, big-time. The starting price on the Cayenne Turbo S is $146,995. We were able to configure one up to $180,000 without much effort.
Nice: Ram 1500 Laramie Longhorn EcoDiesel
The Laramie Longhorn EcoDiesel landed on the "nice" list for two reasons, because it's shockingly lavish for a 1/2-ton truck and for having the best fuel economy in its class. The tester at our Truck of the Year competition topped $60,000, but got 28 mpg highway in our own scientific fuel economy testing. So if you feel any residual guilt for the self-indulgence on getting the Laramie Longhorn package, rest easy knowing Mother Earth appreciates your (relatively) modest carbon footprint.
Nice: Ram 3500 Laramie Longhorn 4x4
It may seem odd that an 8000-pound, $71,000 dually truck is on our Nice list, but with its leather-trimmed interior, and seemingly bottomless reserves of torque from its 850-lb-ft Cummins diesel engine, this big Ram is definitely nice. If you need to tow or haul anything bigger than this truck can handle, you'll need a commercial driver's license, and a Class 7 or 8 truck. Other than maybe being tricky to park in a tight lot, there aren't many downsides to this truck, assuming you can afford it.
Laramie Longhorn
That Benz 6x6
Love my 2013 Outdoorsman!
Ram! Fords flimsy doors ripple when you close them!
Mercedes 6x6 maaad
2500 ram 4x4 Power Wagon
Santa i would like the 2014 rapter please
Anything with a cummins in it.
Dodge ram
G63 6x6 AMG
the Mercedes is insane!
Ram 2500/3500 All the way!
o maquina
X6 M??? Hahahaha
64 c10!! 2014 gmc sierra !!
ford on the naughty cause they suck
Not the dodge.
anche a te!
ahah grande greg! ;)
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Dodge best truck 2013 and 2014.
Sierra denali
Range rover evoke crap back eindow size of s stsmp. Nice jeep commander fully loaded
Mercedes Luv
i'll take the dodge.
Ram 3500 dually!!!
Eco boost f150 on nice and raptor on naughty
Nice: The 2012 RAM 1500 I already own, Dodge Durango R/T AWD
Naughty: Grand Cherokee SRT an a F150 Raptor for the weekend
Dodge 2500 laramie 2014 :)
Toyota tundra
Ford F-450 crew cab
Nice: dodge durango, cadillac escalade, Naughty: hummer h2 sxt
Lorenzo Baffo Maffioletti Questo magari ti piace, auguri di buon natale...!
dodge is way better than a raptor cause mine spanked one
F250 6.7 4x4 extended cab
vw toureg.a ah,my landrover
Just the new raptor.
12 ram rt, 12 ram runner, 03 lightning, 91 syclone,12 srt8 jeep, and 78 lil red express
2013 , Dodge Ram 3500 , dually , long bed , that's on my list , oh wait Santa just delivered.
that 6x6 would be at the top!
Dodge on the naughty because they are junk, Ford on the nice because they are tough, and now Santa drop me a 2014 Raptor thanks!


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I'm a 30yr male living in San Francisco. I recently moved to San Francisco (to work in Silicon Valley) after living on the north side of Chicago for about 8 years. I frequently travel between SF and Chicago, and I'd like to stay at a place that feels more like home when I visit.
I am clean, respectful, and personable. Even when I'm staying in hotel rooms, I make an effort to keep the place neat and tidy (hang up the towels, wipe off the sink, trash in trash cans, etc). At home I am committed to living in a bright, clean, and organized space, and I bring the same commitment along when I travel.


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California - Register Off-Road Vehicles, Snowmobiles, Motorhomes, RV and More With The CA DMV | DMV.orgFind CA Title & Registration Information for Other Types of Vehicles at DMV.org: The CA DMV Made Simple.
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California DMV Driver Handbook - Download the CA Driver HandbookCalifornia road rules & regulations handbook - View, download, or order a copy of California's driver handbook.
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Mark Wahlberg has become a father for the fourth time. The 38-year-old actor's wife Rhea Durham - with who he already has children Ella, six, Michael, four and Brendan, 16 months - gave birth to daughter Margaret Grace on January 11 at Cedars Sinai Medical Center in Los Angeles.
A source said: "Mark was in the delivery room with Rhea. And he cheered her on all the way. Rhea was a real trouper, and now they can't wait to get home and be a big happy family with their four kids."
The 'Lovely Bones' star revealed last October that he and his model spouse - who he married last August after eight years together - were expecting their second baby girl.
He said: "I'm having another girl. So I'll have two girls and two boys." While the family were thrilled to be having a fourth child, Mark was adamant that they will have no more.
He said: "I'm the youngest of nine, and my dad has a few others. No, four is enough. We were all raised with a lot of love. But we didn't get the kind of attention I think that we all needed. "My parents had to provide to put food on the table. My mission in life is to raise my kids right. With all the success I've had in the world, if I fail at that, my life means nothing."
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This week the goons were tasked with wrecking havoc on a bunch of poor innocent stamps. As can be expected, there were a lot of naughty jokes and an alarming number of Yakov Smirnoff references. Yes, I consider two an alarming number. This was the horrifying image that started it all:
"SydBarrett" remembers how scary the late 70s and 80s were:
"DirkPeters3" delivers this ominous message:
"Arsenal" sure gayed up Mothra! He must have a knack for that.
"Phear" just zinged you good!
"Mein Eyes!" wants to know all about you:
Tucker Carlson's idiot brother just called New York mayor Bill de Blasio's spokeswoman a "LabiaFace."
Hey, have you guys ever seen a picture of a cat before? Well, guess what. It's your lucky day, because I'm mixing the concept of a picture of my cat with the concept of the Internet!
A psychic terrorist travels to the 1990s to win his true love by murdering her entire wedding party!
The SA Goons deliver another knockout round of soccer GIFs!
Get caught up on these last-minute Bloodborne changes and read our review!
Photoshop Phriday showcases the tremendous image manipulation talents of the Something Awful Forum Goons. Each week they tackle a new theme, parodying movies, video games, comics, history, and anything else you can think of. If you want in on the action, join us on the Something Awful Forums!
Copyright ©2015 Rich "Lowtax" Kyanka & Something Awful LLC.


text:
Concussion forces NFL player to quit
An American Footballer announces his retirement after one season amid concerns from the effects of concussion.
NFL pair to donate brains for research
New York Giants' Steve Weatherford and former NFL player Sidney Rice want their brains to help research into injuries.
Video & Audio
- Watch What happens at a soccer tailgate?
- Watch How important is the Super Bowl?
- Watch Superbowl XLIX preview
- Watch Christian Malcolm tries Gridiron
- Watch NFL star refuses to play ball with m…
- Watch 'I'm just here so I won't get fined'
- Watch No knowledge of deflating - Belichick
- Watch Raucous Ohio football celebrations
- Watch 'Brain changes' in US football players
- Watch Protecting heads in American football
- Watch Soccer seen as 'sissyball' in Deep S…
- Watch Call for NFL to lead against abuse
- Watch Twitter protest takes to the streets
- Watch NFL London franchise 'a great thing'
- Watch Is college football to blame for NFL…
- Watch NFL stars take Great British quiz
- Watch From a Manchester estate to the NFL
- Watch 'Kids must dream big!' - Menelik
- Watch Man Utd 'a wonderful franchise' - Gl…
- Watch Malcolm Glazer's Man United legacy
- Reinstate NFL star, judge rules
- College sport site profiles 11-year-olds
- NFL concussion settlement 'close'
- Seattle's Lynch escapes NFL fine
- Super Bowl sets US TV ratings record
- Browns' Manziel enters rehab
- Patriots beat Seahawks 28-24
- 'NFL flourishes amid mayhem & chaos'
- Super Bowl, superstars & supermodels
- Super Bowl parties: What you need to know
External Links
- External link: NFL Official Site
- External link: NFL UK
- External link: NFL 360
- External link: NFL Team Picker
- External link: British American Football
Around the Web
- External link: Webster's World
Scores, Results & Fixtures
Super Bowl XLIX
Patriots beat Seahawks 28-24
The New England Patriots overcome the row over 'deflate-gate' to beat the Seattle Seahawks and win the Super Bowl 28-24.


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Hospital Construction and Arrival Information
Helpful resources to ensure the best possible experience as you visit
Front Door Greeters
Our greeters give patients wheelchairs and help with other needs as they arrive. Look for them at these locations:
- University Hospital main entrance
- Battle Building at UVA Children's Hospital main and 11th Street Garage entrances
- West Complex Jefferson Park Avenue and Hospital Drive entrances
- 1222 Jefferson Park Avenue
- Emily Couric Clinical Cancer Center
- 415 Ray C. Hunt Drive at Fontaine Research Park
- Northridge
Hospital Expansion
Over the past several years, we've expanded University Hospital with 72 new inpatient rooms and completed the Battle Building at UVA Children's Hospital and the Emily Couric Clinical Cancer Center.
We recently expanded the University Hospital lobby and built a new climate-controlled pedestrian bridge between the Lee Street Garage and University Hospital. These changes help provide our patients with the experience they expect and deserve and support our employees in delivering exceptional care.
- Getting Here (PDF)
- Patient Drop-off and Parking (PDF)
- Discharge/Departing (PDF)
Construction Update
Due to construction of a new building between Emily Couric Clinical Cancer Center and Lee Street Parking Garage, the entrance to the cancer center has changed. See the new entrance and download a map of UVA Hospital.


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A Papua New Guinea NGO is accusing Australia of being the largest beneficiary of illegal logging and exploitation of PNG's rainforests.
Act Now's comments come as Australia prepares to host...
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Environmental lobby group Greenpeace has given the Papua New Guinea government its Golden Chainsaw award for failing to protect the country's rainforests.
Greenpeace handed the dubious honour to a PNG representative on the sidelines of the Convention of Biological Diversity in Nagoya, Japan.
It also released a report arguing PNG should not be given money to save its forests under the United Nations' Reducing Emissions from Deforestation and Degradation plan.
Greenpeace PNG spokesman Sam Moko says the government has no plans to stop rampant logging at home.
"The government is turning a blind eye to the ongoing illegal logging, corruption and abuse of Indigenous peoples," he said.
Previous recipients of the Golden Chainsaw include Malaysian and Brazilian logging companies.
Chatham House is assessing the scale and effectiveness of the response to illegal logging and the related trade around the world. Full details of this work, including analysis and data, will be available online soon.


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Advocacy of global issues
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Ngoma Aid Foundation
Ngoma Aid Foundation is a non-profit community-based organisation that has a central focus on rural community development. The organisation's programmes include education, HIV/AIDS awareness, direct service delivery, agriculture, income generation, protection of the environment, and general...
Soha Foundation
The Soha Foundation is an NGO in Pakistan. The Foundation works on community mobilization and through volunteer support forums in the areas of human rights, peace and security, child and women's rights and protection, and poverty alleviation.
Association Evangélique d'Appui au Développement (AEAD)
Association Evangélique d'Appui au Développement (AEAD) was established in 1992 in Burkina Faso to assist the poor and needy through socio-economic activities and evangelisation. The organisation runs a range of programmes focussing on health, the environment and formal and informal education in...
Christian Organization for the Child and Sustainable Development- International
The Christian Organization for the Child and Sustainable Development- International COCSD-INTEL is an NGO in Zambia. The organisation aims to fight against discrimination, hunger, disease, malnutrition, illiteracy, domestic violence, child abuse and stigma. Its target groups are orphans, women,...
Luhwahwa Youth Development Foundation (LUYODEFO)
The Luhwahwa Youth Development Foundation (LUYODEFO) provides support to marginalized communities across the Kasese district of western Uganda.
Depressed and Traumatised People of Uganda (Detrap-U)
Depressed and Traumatised People of Uganda (Detrap-U) is a new Ugandan NGO established by psychosocial/ rehabilitation professionals and victims of traumatic experiences. The organisation aims to use local solutions to alleviate mental and psychological sufferering. Detrap-U is currently involved...
Africa Youth Initiative Network (AYINET) - Zambia
The Africa Youth Initiative Network (AYINET) is a youth organisation in Zambia. AYINET aims to support youth initiatives that promote increased participation of young people in issues requiring policy outcomes. The organisation also advocates for adequate educational opportunities from primary to...
Full Gospel Churches of Kenya - Njiru Branch
Full Gospel Churches of Kenya - Njiru Branch is a branch of the Kayole Local Church, a religious organisation. The church is based in Nairobi and has 60 members.
Organisation De Opportunity Uganda
Organisation De Opportunity (ODO) Ugandan is an NGO that reaches out to vulnerable groups. ODO Uganda supports human rights and good governance; gender and women in development; children and young people; health; the environment and natural resource management; public information, education and...
Women Rights Action Group (WRAG)
The Women Rights Action Group (WRAG) is a Tanzanian NGO. The organisation aims to improve the social economic welfare of women through education and health programmes, and through promoting their human rights. WRAG also fights against HIV/AIDS. WRAG is currently involved in a capacity building...


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Some Kind of Fairy Tale (original 2012; edition 2013)
by Graham Joyce
Work details
Some Kind of Fairy Tale by Graham Joyce (2012)
Faerie Mythology (63)
KayStJ's to-read list (594)
No current Talk conversations about this book.
Yes I gave it 5 stars. I was thoroughly enchanted. I am left with some kind of....longing. I know I am 40 something...but...I believe. I believe. I believe. I will now hunt down every book by Graham Joyce and read it.
Yes I gave it 5 stars. I was thoroughly enchanted. I am left with some kind of....longing. I know I am 40 something...but...I believe. I believe. I believe. I will now hunt down every book by Graham Joyce and read it.
Loved this one. First book by Joyce and will definitely be reading his others.
If you haven't read any Graham Joyce up to now (like me) and you like the kind of fantasy that has a real-world base (I'd call it urban fantasy a la Charles de Lint except this story takes place in a semi-rural setting), a solid grounding in the 'lore' of the fae and wonderful characters and dialogue... well.... you are in for a treat and a half. My husband discovered Joyce and bought up a pile of his novels after reading the first one and now I know why. A young woman, Tara, comes home after being missing for twenty years, presumed dead, although it is an unsolved mystery. She claims that she has only been gone six months. As her parents, brother, and former boyfriend struggle with coming to terms with the story she tells them..... that she was taken into.... another realm... Tara herself has to come to terms that whatever else, the time has passed and the changes in herself and in her family, much as she loves them.... the minor plots, the trials and tribulations of a thirteen year old boy, for example, weave marvellously into the bigger story. I'm considering knocking this up to a five, given that I did that thing where you just check out of RL and read like a madwoman until, uh oh, last page. ****1/2
On Christmas Day, Tara Martin appears on her parents' front doorstep. This would not have been at all strange, had she not been missing for twenty years. And also had she not looked a day over 15, the age she was when she disappeared.
Those of you who grew up with a certain kind of story can probably guess what happened to Tara from those three sentences alone. And you'd be right.
But the beauty of Some Kind of Fairy Tale lies not in treating Tara's time in the fairy world as a plot twist, but in presenting it to the modern world and asking that world, "Well. What do you make of this, then?"
This would have been more interesting had there been a greater variety of answers to the question in the book itself. As it is, the majority of people whom Tara comes across think that she is in her mid-thirties and for whatever reason suppressing the fact that she's been missing for twenty years. Initially both possibilities seem equally plausible, but as the novel progresses it becomes increasingly clear that Tara actually did make a journey; everyone in her family's world simply cannot accept it. By the end it felt as though the story had become a modern-day middle-class morality play (to wit: Tara complains that the light has gone out of Peter and Richie, that they were the hope and the future, but they have succumbed to modernity like everyone else). This frustrated me, as it felt like Joyce could have made much more of the story – he certainly has the skill for it, and his prose is beautiful, but I felt like the contrasts drawn between the fairy world and the real world became heavy-handed and even a bit unfair.
It's the sub-plots initiated by Tara's return which made this book so much fun for me to read. Tara's sudden reappearance, and all the joys and problems which come along with it, profoundly shake up the lives of everyone around her. Way back when, her brother and parents had blamed her boyfriend, Richie, for her disappearance. Peter and Richie went from being best friends to not speaking for twenty years. Now they're back in each other's lives, and seeing Peter with his family as well as talking to Tara makes Richie drastically reconsider his lifestyle. Another sub-plot, involving Peter's son, next-door-neighbour Mrs Larwood, and Mrs Larwood's cat, begins tragically but quickly becomes probably the most adorable in the whole novel. I really enjoy old ladies in novels who know a great deal more than they let on; Joyce reveals her character by subtle degrees, and I would have loved to have seen much more of her. In contrast, though, I felt that the development of the fairy culture occurred much less deftly; Tara goes from hating being there to nostalgic without there really being very much in between, which made it difficult for me to sympathize with her or even find her much more than a petulant teenager. This was a shame, since I found the world enthralling, and would have liked to experience it through…someone else's eyes.
Therein lies the great strength of Joyce's novel: each of his characters, even Mr and Mrs Martin the elder and Peter's daughters, characters who receive comparatively little attention, feel like individuals, like people. Not even the psychologist or the fairies feel like stock characters. Every single one has their own desires and motives, and every single one changes develops throughout the course of the novel. Perhaps somewhat ironically I felt that Tara actually developed the least, but she did grow to a sort of acceptance of her circumstances, something which I greeted more with disgruntled relief than joy. Overall, though, between the strong characters and the strong prose, I enjoyed Some Kind of Fairy Tale, and would recommend it, particularly to the fairy-tale-inclined.
References to this work on external resources.
Wikipedia in English
Amazon.com Product Description (ISBN 0385535783, Hardcover)Acclaimed author Graham Joyce's mesmerizing new novel centers around the disappearance of a young girl from a small town in the heart of England. Her sudden return twenty years later, and the mind-bending tale of where she's been, will challenge our very perception of truth.
For twenty years after Tara Martin disappeared from her small English town, her parents and her brother, Peter, have lived in denial of the grim fact that she was gone for good. And then suddenly, on Christmas Day, the doorbell rings at her parents' home and there, disheveled and slightly peculiar looking, Tara stands. It's a miracle, but alarm bells are ringing for Peter. Tara's story just does not add up. And, incredibly, she barely looks a day older than when she vanished.
Award-winning author Graham Joyce is a master of exploring new realms of understanding that exist between dreams and reality, between the known and unknown. Some Kind of Fairy Tale is a unique journey every bit as magical as its title implies, and as real and unsentimental as the world around us.
(retrieved from Amazon Mon, 30 Sep 2013 13:44:16 -0400)
After missing for twenty years, Tara Martin appears on her parents doorstep barely a day older than when she vanished.
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Justice Design Group WGL-8561 - Arcadia 1 Light Wall Sconce - Cylinder with Flat Rim Shade - Dark Bronze with Grid with Clear Bubbles GlassItem # HN-JDG2689
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Just wondering if White Grubs eat hosta roots? Looking for your expertise on this!
Around here they eat grass roots, tomato roots, and everything else under the soil. I put Bayer killer stuff in my pots so my hostas are safe from them as well as the weevil larva. Get rid of them!!!
At some point, those white grubs will come out of the ground as beetles. Douse them with soapy dish water.... instant death!


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H. lacunosa 'Royal Flush'
Okay, decided to hit the OTHER Lowe's (4 in a 15 mile radius) . . . and found 'ROYAL FLUSH'! And I grabbed it. I just couldn't help myself.
Carolyn, too funny...Mike and David were just saying on another thread how hoyas can be like a drug...I would say you're totally addicted and "you're hooked" big time,lol...Congrats on your great find!
Are you running out of room yet...or is that not an issue? You must have great Hoya Karma, you find all the good ones :o)
There is one at a Lowe's near where I work....however, last I saw it, the pot was REALLY heavy, so I'm wondering if it's overwatered. I love my speckled one so much that I'm not really interested in this one.
If anyone is interested I can check again on Monday- just send me an email in case I don't check the forum....feel like I was suppose to be watching for this one for several people and now I can't remember who....
dalette, none of the box stores in my area know ANYTHING about plants . . . and they know even less about hoyas. Last year, I walked up to the MANAGER of the garden area and asked if he had any hoyas. He told me they never carried hoyas. I walked to the houseplants and found four different species. go figure!
It's that they don't know what Hoyas are.
I stopped at my local HD last night & found a large, full pot of Curtisii, & some small, no ID KQ types & 2 Balfour Aralias (another favorite of mine).
I know some of the staff there, some of whom had told me the store requires them to water twice a day, while even their workers know that's too much. Well last night, they told me they're now forced to water 3 times a day!!!
My plants were literally soaking wet. I took them home & unpotted & have them blotting on newspaper.
Haven't yet seen Royal Flush, I'll scoop it up when I do!
Isn't it awful, Karen? I understand that when it's very hot, they need to keep the outside plants watered because of the heat and the very light mix they're in. But the EA plants, which they keep indoors (at least here) have a mix that holds the water AND they're not out in the heat. I think someone came down with that imperitive for OUTSIDE plants, but in the translation, they took it to mean ALL plants. If I worked there, I'd be raising heck with someone! Like, "Hm, maybe there's a reason plants die fast in our care?! Maybe we should be trying to figure out what that reason is??"
Denise in Omaha
Well that would certainly explain why the plants at Home Depot always look so horrible.
I got a lacunosa 'Royal Flush' last month from Lowes; surprisingly it was on the half-price rack, though it was in perfect condition.
All they had today were a couple carnosas and something mislabeled as lacunosa.
Beyond words Denise, I couldn't believe it when they said THREE times a day.
Yet, the plants all look really good at this HD, tho' I mostly go on a Friday & suspect I could be looking at newly arrived plants. I believe they get new stock 2-3 times a week, maybe including Fridays, who knows?
I DO feel a bit like I should open an office there or get free plants in exchange for all the counsel I give fellow shoppers for plants, especially the newbies. I dissuaded 2 people from buying Glufers (Jeff would be proud), explaining to them that the flowers were fake & glued on, they looked astounded!
Hey Carolyn,
I went to our Lowes yesterday to get some paint and as always have to walk thru the plant section. They had a few linears and a RF lucanosa. you probably know how the story ends. . .lol :) I'll post pics so we can compare. . .


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American Range Performer finally on the American Range website!
It's a miracle.
Some caveats I found:
Top burner BTU is incorrectly listed as 17k BTU. Actual is 25k BTU for the Performer. I confirmed this by calling American.
Also, typos abound, including in the name of the product itself on some pages ("Preformer???"). Hey, at least there's some progress there. But American needs to understand this lack of attention to detail doesn't inspire consumer confidence.
I bought their range and wall oven. The range is great, but the wall oven has broken for the 4th time in 3 1/2 years and they don't understand why I am upset, nor do they know why it is breaking. They feel they have been very generous to offer me the part free of charge with no assurance of not having continual problems. You out there in consumer world can decide if that is generous. I am already out quite a bit of money for the 2 repairs I completed after the initial warranty repair.


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Editor's note: This post originally appeared in a slightly different form at National Review Online.
It has taken liberal school reformers almost no time at all to throw the race card into the debate about reauthorization of the No Child Left Behind Act of 2002.
Eager to retain an expansive federal role, but finding it tough to argue this position on the merits, liberal reformers have rushed to charge that the current effort to dial back the federal role is a thinly veiled attack on minority children.
Perhaps the best example of this phenomenon was provided just the other day by a Daily Beast column penned by Jonah Edelman, CEO of the education advocacy group Stand for Children. Edelman is the scion of two liberal icons: Marian Wright Edelman, founder of the Children's Defense Fund, and Peter Edelman, a Clinton administration official who famously resigned to protest welfare reform. Jonah is also a friend and a smart guy, and Stand for Children has done some laudable work.
Unfortunately, that's what makes his column so notable when it denounces any effort to reduce the federal role as a surrender to the forces of "racism, politics, ignorance, [and] indifference." Edelman perfectly illustrates the problems with liberal-flavored school reform and its hollow calls for "bipartisanship."
In the piece, Edelman denounces efforts to shed some of No Child Left Behind's more onerous and unworkable provisions as a "threat" to "your kids' future." He then recounts a parade of horribles from the last century. "Linda...
Ohio's Quality Counts Rating – Poverty Gap Change
In Monday's post, we examined the achievement gains Ohio has made on the NAEP exams from 2003 to 2013. Needless to say, Ohio's gains were not all that impressive. In this post, I look at how Ohio fares along the "poverty-gap closing" measure used in EdWeek's Quality Counts report. (This metric is the difference in NAEP achievement between low- and high-income students—and how that gap has changed over time.) The achievement gap between poor and well-off children is substantial across the entire nation, Ohio included, and thus minimizing the differences in achievement levels is a worthwhile policy objective (preferably, by lifting the achievement of poor students, not through reductions in wealthy-students' performance). The chart below displays the "poverty gap" trend in Ohio, along with several other states: four other Midwestern states, the four most-populous states, and the national average. Among these states, Ohio had the largest increase in the achievement gap; its gap grew 3.3 points from 2003 to 2013. The state also ranked near the bottom nationally on this indicator—38th in the nation, taken as an average of its math and reading ranks. Meanwhile, New York was the U.S. leader in achievement-gap closing during this time period, shearing off 5.2 points in its gap between low- and high-income students. Ohio has a growing achievement gap between its poor and wealthy students, and in fact, one of the worst achievement-gap trends in the nation.
Monday afternoon, a Washington, D.C., metro rail train stopped in a tunnel not far from a major station, and the car began filling with smoke. Soon the lights went off and, though many passengers were struggling to breathe, they were told by metro employees to stay put. A spokesman for first responders disputes the timeline, but the Washington Post spoke with passengers who said they were waiting as much as an hour before help arrived. The paper also quotes a fire department spokesman who admitted that, even once they arrived on the scene, "firefighters did not immediately enter the tunnel to help the riders because they were not sure whether the subway's electrified third rail had been deactivated."
All told, one woman lost her life and eighty-four were hospitalized. In the coming weeks and months we will learn more about how this happened, whether the response was adequate, and whether the accident and subsequent loss of life could have been prevented.
To many riders, accidents like this are not surprising. A 2009 train collision killed nine people. There are also years' worth of examples documented by bloggers, everyday riders, and journalists of seldom-enforced rules, sloppy workmanship, and bafflingly onerous collectively bargained work rules that sacrifice quality and safety in the interest of other union priorities.
To top it off, system leadership will often downplay the problems to make it seem like everything is under control. A post from Cato's Walter Olson after...
Last week, I explained the reauthorization of the Elementary and Secondary Education Act (a.k.a. No Child Left Behind) in a single table:
Now that Senator Alexander, chairman of the HELP Committee, has released a draft bill, let's take a look at where it stands on these various issues (items that moved are in bold):
In brief, most of my "yellow" items went to red—as in, they got left on the cutting room floor. Just testing in science and a version of School Improvement Grants made it to the "green" territory.[1] And most intriguingly, annual testing—the star of the current debate—stays in yellow thanks to Alexander's equivocation on the issue. (He included two options in his bill—either keep the current annual testing requirements or let states propose something that is similar in spirit.)
To be sure, this is just the opening bid. Conservatives will aim to shrink the green list, and liberals will aim to grow it. What's still not known is where the president's "red line" may fall. Stay tuned!
[1] As several readers noted, the School Improvement Grants program is officially gone, though the bill does include a large state set-aside for school improvement activities.
THE DRAFT BILL IS HERE...ALMOSTReporters are gathering details on Senator Lamar Alexander's much-awaited draft bill for reauthorization of No Child Left Behind. The bill is more than 400 pages long and outlines two roads for standardized testing: A Choose Your Own (Testing) Adventure or "stick with the assessment language we pretty much already have," note the Politics K–12 duo.
WALKER: TESTING RANGEREducation Week's excellent State Edwatch blog has an in-depth examination of Wisconsin Republicans' new state education plan, called for by Governor Scott Walker during last year's reelection campaign, which would convert persistently failing public schools into charter schools. Also included in the legislation is a proposal to grant broad leeway to public, charter, and private schools to select from a menu of competing standardized tests.
BOARD TO DEATHAmerican University's WAMU takes a look at the responsibilities of charter board members in Washington, D.C., a city in which nearly half of all children attend charter schools. Carrie Irvin, head of a nonprofit that seeks to train the volunteer board members, says that the duties of the position can be demanding: "Serving on a public charter school board is not 'I'll show up twice a year, vote like the guy next to me because he looks smart and put it on my resume.' It's a serious leadership responsibility."
INTEGRATION AND THE ACHIEVEMENT GAPThe Supreme Court will be hearing a case next week concerning disparate impact of housing policies on racial...
The president may have stiffed the French at the big solidarity rally that many other world leaders attended over the weekend, but when it comes to domestic policy, he is in love with the universe—and universality.
First, of course, came universal health care. But it was followed in short order by his plea for universal preschool education and, last week, for universal community-college education. All free, of course, at least for the consumer. (Not, obviously, for the taxpayer.)
In health care, there's at least a rational basis for demanding universal insurance coverage: to apply the "savings" from healthy people who don't need medical care to subsidize the care of those who need lots of it. (Social Security and Medicare run the same way, except their "do get" and "don't get" populations are demarcated explicitly by age rather than health status.)
In education, though, the trade-offs tucked into universality are more insidious—and actually harmful to authentic "need lots" people, while conferring taxpayer-financed windfalls on the "don't need" population.
Most American four-year-olds and many three-year-olds already take part in preschool of some kind, and a great many of their parents have figured out how to pay for it with the help of employers, local school systems, private philanthropy, and others. Many other little kids are satisfactorily looked after by family members and caregivers in their own homes. And lots of them enter kindergarten ready to succeed there. Children like these do not need a "universal" program. For their families, it's just...
BLENDED LEARNING UPDATESchools across the country are experimenting with the blended learning model in which classrooms feature a mix of human capital and online tools to deliver lessons. This NPR profile of a Coney Island middle school is a revealing examination of the approach. While the integration of technology can ease the "administrative" duties of teachers, such as tracking student progress, researchers say that there is still no concrete evidence for academic or developmental gains. The key takeaway is that blended learning is not a silver bullet.
UNTRUE GRITThe New York Times wades into the character-education debate with an overview of different views and voices. While some research (and a host of different schooling models, most notably that of the KIPP schools) emphasizes the value of skills like grit, curiosity, and self-control, other experts argue that obsessive perseverance can be stifling and that overweening focus on character growth will obscure the debate over school quality. No less an eminence than friend-of-Fordham Laurence Steinberg took to Flypaper last year to air his misgivings about the practice.
CHANGING THE CHARTER NARRATIVEThe conventional wisdom on charter schools, Forbes's Adam Ozimek observes, is that their performance essentially mirrors that of public schools, barring a few outstanding exceptions. After reviewing the most recent studies conducted by CREDO and Mathematica, however, he concludes that charters' value to poor and minority students and English language learners is actually greater than their district equivalents....
The nineteenth edition of Education Week's Quality Counts report is out, and while Ohio outperforms over thirty states, the results show that there is still much work to be done. The 2015 report, which has a new evaluation system that focuses on outcomes rather than policies and processes, indicates that the nation as a whole declined from a C+ in 2013 (when grades were last given) to a C in 2015. Ohio also declined, moving from a B- in 2013 to a C in 2015. The report rates states' quality along three key dimensions: Chances for Success, which takes into account indicators like family characteristics, high school graduation rates, and workforce opportunities; K–12 Achievement, which rates academic performance, performance changes over time, and poverty-based gaps (as measured by the NAEP assessments); and school finance, which includes measures of funding equity across schools. Ohio's overall score, which is the average of the three categories, was 75.8 out of 100 possible points, which earned a ranking of eighteenth in the nation. In the Chances for Success category, Ohio earned a B-. Most indicators in this category show that Ohio is close to the national average, including preschool enrollment (46.5 percent of Ohio three- and four-year-olds compared to 47.3 percent nationally) and percentage of adults with a two- or four-year postsecondary degree (37 percent of Ohio adults compared to 39.9 percent nationally). In the K–12 Achievement category, Ohio earned a C-. Although this places the Buckeye State at sixteenth in the nation...


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Students studying mathematics at Grove City College also have the option to concentrate their studies in actuarial sciences. Students complete advanced coursework in statistics, finance, risk and insurance, investment management and investment valuation. Upon graduation, students are well prepared to excel in competitive graduate and professional programs, as well as gain immediate employment in a wide range of industries including insurance and financial services. Students should refer to the College Bulletin or the major status sheet for complete information regarding major requirements.
Students studying mathematics at Grove City College also have the option to concentrate their studies in actuarial sciences.
Students graduating from the Department of Mathematics are well poised for a wide variety of career paths including education, computer and information sciences and business.
Take an in-depth look at recent Grove City College student and faculty scholarly work in the Hopeman School of Science, Engineering and Mathematics.
Recently, students majoring in mathematics have interned at Buck Consulting, Towers Perrin, Erie Insurance and more.
Recommended resources by the Department of Mathematics faculty at Grove City College.
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Barre U-13 squad earns title berthFebruary 25,2014
Barre U-13 squad earns title berth
This past weekend's State Tournament for Peewee AA youth hockey teamsfeatured plenty of drama and excitement at the Georgetti and Spartan Arenas in Rutland.
Barre's under-13 team suffered a 6-1 loss to Essex in Saturday's opener, with Tyler Murray scoring the lone goal for the Granite City squad. Rutland skated to a 5-3 victory overBarre in the following game, with Murray scoring two goals and teammate Parker Spaulding adding another.
Barre returned Sunday without a serious chance to advance in the tourney, but goals from Murray and Heath Atwood helped fuel a 2-0 victory over Middlebury. After hours spent waiting to find out which teams moved onto the semifinals, Barre wound up in third placeafter edging fourth-place Rutland by 0.5 points in the standings.
Barre's players returned to the iceagainst Essex knowing it could be their last game and served up a 6-2 victory. Murray led the way with a hat trick,Taylor Coburn scored twice and Spaulding also found the back of the net. Barre also received a lot of offensive contributions from Jesse King and Daniel Ruel. Cam Gosselin, Owen Kresco and Miles Aja anchored the defense in front of tough goaltending by Kyle May.
Barre will travel to play CSBon March 7 at 7:30 p.m. in the championship game in Middlebury.MORE IN This Just InWhen a playwright who has achieved success with dark realistic drama turns his pen to comedy, it... Full StorySAN FRANCISCO A long legal battle over accusations that a prominent Silicon Valley venture... Full StorySHARM EL-SHEIKH, Egypt Yemens embattled president on Saturday called Shiite rebels who forced... Full Story
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