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|Property type
|Minimum Stay
|2 nights
*Sea Esta Shores B*
The best priced direct oceanfront property on the South Beaches. Tremendous views and sunsets with a private path leading to the Pacific. Great oceanside deck and yard space for relaxing and conversing.
We are an owner managed direct oceanfront duplex vacation rental home which joined the market in December, 2012. Sea Esta Shores sits down a private drive and is situated directly oceanfront, about 300 feet back from the Pacific. There is no tall brush or sand dunes to obstruct your ocean and sunset views. You will find a private path which leads directly to a very quiet location on Twin Harbors Beach. Plenty of parking directly in front of Sea Esta Shores makes loading and unloading a breeze. We are just 3 miles south of the downtown Westport docks and boardwalk area. We offer the peacefulness of being oceanfront yet are minutes from your daily coffee, groceries, restaurants and the city docks of Westport.
During the summer months the beach out back is closed for motorized traffic. Often one finds themselves strolling down the beach with not another person in sight.
Since our ownership in December of 2012 we have added many enhancements and improvements to Sea Esta Shores.
Inside and out you will find authentic nautical décor adding to your oceanfront vacation experience.
Sea Esta Shores is a two-level home with entrance on the lower level. On this floor you will find two bedrooms, bathroom and washer/dryer. The beds are comfortable with new linens. On summer nights you can crack the windows and fall asleep to the sound of the ocean.
As you approach the top of the stairs you are greeted by a tremendous view of the Pacific Ocean. On the upper level you will find a great room featuring a large living room area, game table and full kitchen with dining area. The kitchen is fully stocked including double sink and dishwasher, dishes, glassware, cutlery and pots/pans are new and of nice quality. Small appliances such as toaster, coffee maker, electric hot water pot and crock pot are all provided. A large steaming pot is provided for those fresh caught crabs caught at the Westport docks.
Seating in the living room features 2 nice recliners and a comfortable couch. The couch is a sleeper sofa which offers a very high quality Air Dream mattress. There is a nice selection of DVD's, games, books and puzzles which can be enjoyed at our oceanside game table. A soothing electric fireplace warms the room on those cool nights.
The living room has a flat panel television and DVD player. The upper level is very open with a vaulted wood beamed ceiling and skylights. A sliding door leads to the oceanside deck. Regardless of your location on the upper floor you have an unobstructed view of the ocean.
WIFI, DirectTV, DVD player, a nice selection of movies and board games are provided for our guests' enjoyment. Enjoy your morning coffee on the oceanside deck while surfing the net.
*Oceanside Deck*
Each unit of Sea Esta Shores features a 200 plus square foot private deck. The deck furnishings are quality bamboo furniture with additional Adirondack chairs. There is a stand up bar on the deck which has proven popular for enjoying a beverage while watching the ocean or the sunset. The deck is gated to help keep the little ones and four legged friends contained. Catching a clear night for a sunset or star gazing from the deck is spectacular.
*Oceanside Yard*
Just off the deck you will find the oceanside yard. Sea Esta Shores has a swing, a picnic table for each unit, horseshoes, custom brick barbeque, a fenced dog run and a sand box with beach toys for the little ones. Here you will also find a short path leading to the ocean. Whether you are pitching horseshoes, grilling dinner or dining at the picnic table you will enjoy the unobstructed ocean views which the yard offers.
*Dog Friendly*
Sea Esta Shores is dog friendly. Our oceanside deck is gated and our yard features a fenced dog run. You will also find dog bowls, towels for the paws and dog treats. A doggie rinse station is located in the front of Sea Esta Shores. If you are wishing to bring your dog for your stay please provide the dog's breed, approximate weight and name of the dog.
*Clam Digging and Crabbing*
Sea Esta Shores sits just back from Twin Harbors Beach. Generally razor clam digging season is October through May. Sea Esta Shores has clamming guns, buckets and shovels. A fish/clamming station is located in the front of Sea Esta Shores.
We also offer crab rings for our guests use. Bring the rings to the Westport docks and spend the afternoon crabbing.
*Rates and Specials*
We believe you will find Sea Esta Shores offers very competitive rates for a direct oceanfront home.
Single night stays consider depending on time of year. Single night stays slightly higher rate.
At Sea Esta Shores we do not charge an additional cleaning fee. At many locations the cleaning fee can add $60-$100 to your stay.
Our rates are good for 1-4 guests with additional charge of $10 per day for 5/6th guests. A refundable damage deposit and sales/lodging tax is required. Thru VRBO you can pay online using a credit/debit card or electronic check. Depending on how far out your reservation is your payments may be broken up between 2 payments.
We offer discounts on stays of 7 nights or longer and for guests renting both units of Sea Esta Shores.
*Sea Esta Shores has 2 units available*
Being an oceanfront duplex means we have 2 units available for vacation rental. Smaller families can rent one unit and enjoy an affordable oceanfront vacation. Larger families and groups can use both sides for that oceanfront vacation experience. Unit A of Sea Esta Shores is VRBO number 446947.
Planning a family reunion, an ocean wedding or maybe an extended oceanfront visit? Contact us and we'd be happy to discuss your plans.
*Contacting Us*
We welcome inquires thru VRBO, emails and phone calls regarding your stay at Sea Esta Shores. When working with us you are speaking directly to the owners of Sea Esta Shores. We will make sure you receive the attention and high level of service which your oceanfront stay at Sea Esta Shores deserves. Whether you stay with us for a weekend or 2 weeks, your satisfaction is important to us. We look forward to hearing from you.
Ready to reserve your vacation days?
If you are ready to reserve your ocean time at Sea Esta Shores please use the 'book it' feature in the upper right of our listing. Here you will enter your days, number of guests, if you are bringing a dog or not and a place for a message to us. Please include a tidbit about your time requested and your dog (if applicable). It is important for us to be a good fit for our guests and for our guests to be good match for Sea Esta Shores.
If you need additional information then please use the 'email owner' feature and we will respond promptly to your question.
We have recently added a third location in the Westport/Grayland area. Casa Sea Esta is an oceanfront single family home located in Grayland. The home is 4 bedrooms, 2 bathrooms and sleeps 8 people. The home offers some of the best views on the South Beaches. The VRBO number for Casa Sea Esta is 687120.
After purchasing this property in 11/2012 and completing many updates, we are pleased to offer our home for your vacation enjoyment. We are locals in Seattle and plan to thoroughly enjoy our vacation home while also offering it to guests for their family vacations.
Eventually we plan on retiring to Sea Esta Shores.
Joel and Denise purchased this house in 2012
We looked extensively for oceanfront properties along the south beaches up to Ocean Shores. After experiencing Westport and seeing this oceanfront home the decision was easy for us. Views from inside the home or on the deck are fabulous....truly unobstructed ocean views.
The oceanfront deck and level grounds allow for tremendous outdoor living space.
Sea Esta Shores sits at the end of a private road with incredible Pacific Ocean views. In addition to a spacious oceanfront deck there is also an oceanfront yard for grilling on the BBQ, dining and relaxing. It is not common to find a direct oceanfront home available in our price range.
Having 2 units at Sea Esta Shores allows for larger groups and families to use both sides and enjoy an oceanfront vacation together. While smaller families are able to enjoy an affordable oceanfront experience in one of our units at Sea Esta Shores.
We believe Sea Esta Shores to be the ideal setting for gatherings of family and friends and for oceanside events such as weddings, anniversaries and those special birthday celebration.
Thank you so much for such a wonderful inviting home. It was perfect in every way! We came from Kennewick, WA & we loved the clam digging. Our last day to dig was the very best as we were spotting them everywhere. We rented both sides & my son & daughter-in-law & 5 grandchildren so we had plenty of space. The privacy, the path to the ocean, the bottle of wine, & the doggy treats were all appreciated so much. We watched movies, played games, walked to beach, & enjoyed smores by the fire pit. The bench swing was used & the back patio. We had some rain, but mostly sunny. Thank you both so much! We are talking about coming back here again next year.
We were in the area for a few weeks while my husband completed a job. I was convinced that we would end up staying at a hotel. We are so grateful to have found this gem of a house for a very good price. Not only does it have the most amazing oceanfront view, but they allowed our two dogs to stay as well. Everything we could have possibly needed was there. I spent days walkinging with my dogs on the beautiful beach collecting shells and evenings watching the amazing sunsets. Truly a perfect stay.
Totally enjoyed our 3-night getaway to the coast (which coincided with my birthday). Direct beach access and dune/beach views couldn't be beat and all the little homey touches were perfect. Close to the "downtown" marina area for a few food options. Super comfortable and hoping to make this an annual or even twice a year trip, schedules permitting.
We just got back from celebrating our 11th anniversary at Sea Esta Shores. It was, as the title says, simply perfect. It was our first time storm watching, and we had a great time. The view from the patio doors was perfect, and we were able to stay warm while watching the waves breaking. It was cozy and there was absolutely nothing we could have asked for. Every detail was included, down to something as simple as a first aid kit in the medicine cabinet. I can't imagine a more perfect weekend.
Loved the place. Way to go if you embark on the adventure with friends or family. Really loved the backyard. Great job of providing dog and kid friendly and fun things in the backyard. I loved your barbecue and bonfire area. Deck is awesome; provides an awesome view of the ocean. Great access to trail to beach. Close drive to the surf spots. I love to surf!!!! The beach vacation very much recharged me for hard work in the world again. Very relaxing place!!!! Thanks very much for the wine and cookies.
This place was amazing! The owners really go above and beyond with making you feel warmly welcomed to the rental with a lovely bottle of wine, some tasty cookies (complimentary from Housekeeping!), as well as prompt and friendly e-mails. The area is such a quiet and peaceful environment. We walked to the beach at least three times a day and otherwise just relaxed in the main living area enjoying the view and/or watching TV. The internet connection was also great for us to use. Our dog had a lovely time as well! He enjoyed some complimentary dog treats too!
The next time we go to Westport we hope to rent both sides and bring some close friends and/or family. Overall, this was exactly what we were looking for! Thank you!
The best place my hubby and I have stayed on the coast. Everything, I mean everything we could have wanted was supplied. No big crowds. Just quiet solitude, yet close to marina and shops. They so nicely provided for our four legged child. Leash, bowls, doggie towel and pad. Our Molly was very content. Definitely will and have recommended. Thanks for the beautiful beach get-away.
Just minutes to the docks of downtown Westport.
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Event Price
Late Winter
6 Feb 2015 - 2 Apr 2015
2 night minimum stay
for 2 nights
|Notes: Rates are based on 4 guests; add $11 per night, per additional guest
Spring 2015
3 Apr 2015 - 25 Jun 2015
2 night minimum stay
for 2 nights
|Notes: Rates are based on 4 guests; add $11 per night, per additional guest
Memorial Day Weekend
22 May 2015 - 24 May 2015
3 night minimum stay
Summer 2015
26 Jun 2015 - 12 Sep 2015
2 night minimum stay
for 2 nights
|Notes: Rates are based on 4 guests; add $11 per night, per additional guest
Labor Day Weekend
4 Sep 2015 - 6 Sep 2015
3 night minimum stay
Fall 2015
13 Sep 2015 - 31 Oct 2015
2 night minimum stay
for 2 nights
|Notes: Rates are based on 4 guests; add $11 per night, per additional guest
Early Winter 2015
1 Nov 2015 - 23 Dec 2015
2 night minimum stay
for 2 nights
|Notes: Rates are based on 4 guests; add $11 per night, per additional guest
Christmas/New Years
24 Dec 2015 - 2 Jan 2016
2 night minimum stay
for 2 nights
|Notes: Rates are based on 4 guests; add $11 per night, per additional guest
Winter 2016
3 Jan 2016 - 3 Mar 2016
2 night minimum stay
for 2 nights
|Notes: Rates are based on 4 guests; add $11 per night, per additional guest
Spring 2016
4 Mar 2016 - 23 Jun 2016
2 night minimum stay
for 2 nights
|Notes: Rates are based on 4 guests; add $11 per night, per additional guest
|Refundable Damage Deposit
|Pet Fee
|$20 + Tax
|Tax Rate
If bringing a dog we require to know breed, weight & name of dog.
Undisclosed pets or additional guests forfeit 100% of deposit.
We will likely contact you prior to accepting the reservation so we can be certain we are a good match for each. We are NOT a party house. We cater to families/friends seeking a quiet & relaxing oceanfront vacation. If this is not you please seek lodging elsewhere.
Please Note: The owner of this property accepts payment in the original currency specified (USD), before use of conversion tool. The conversion tool is provided for your convenience only. The owner may accept other currencies if specifically agreed in advance.


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Ying Yang legend legend CC & E - Legend of Guangdong Ying Yang Advertising Co., Ltd., in the 2005 Campaign Brief Asia. Ranked the most awarded advertising agency in China, ranked sixth, and this is the first honor local advertising companies in China. To this end, "Dragons List" into English Yang legend, after the list opened exciting story. ????Hui Zou Legend: Creativity and Management Compatibility ????Ying Yang legendary founder, executive creative director of Zou Hui, in 2004, inviting creative people Zhengda Ming Meng joined together as Executive Creative Director. In two years, two swords and the wall, successfully challenged the "mountain can hardly contain the two tigers," said. ?????Award-winning ability to be recognized at the same time, one after another in recent years to attract and train a number of emerging cutting-edge advertising, set up a higher quality of the creative team. Zou Hui said: "I and the Ming has been a wish that is able to local Chinese people the best creative focus to the British Young Legend." ????Walked the streets after a copy ????Lin: You are from when, in what opportunity to become a copy of? ????Zou: 93 by the end of the South in the Arts Advertising Co., Ltd. Chun. Since then, I was really involved in advertising circles is the beginning, I do plan a chance, the image of the company to do their own advertising, creative group of people have no idea the Department, I volunteered, like a series of programs The result was chosen, the boss a look, ah well, turn copy it, from me to set things right foot creation of no return. ????Lin: Can you tell be a growth path after the copy it? ????Zou: Art After Chun south, I have to create links to yet, causing Cheng, several local companies were good apprenticeship. At the same time, foreign companies are being stationed in Guangzhou, a creative paradise of my dreams. I secretly vowed, be sure to find a golden statue opportunity to practice foreign companies. ????96 years, a friend of Apple Computer parked in my office, then compiled a manual to introduce ourselves, "a killer experience", the result into the Mackenzie. Guangzhou Light Company. To McCain, only to find even a century-old store, the system is perfect, they begin to devote themselves to learning. In McCain's year and a half, very hard, there were only two writers, but to do all the creative and relevant copy, work overtime almost every day, every week overnight, but foreign companies improve processes, systems thinking, and the pursuit of quality ... ... are learning the different aspects of the treasure. ????Professional atmosphere in the baptism of John McCain, and soon there is a feeling reborn, or is paid off, one after another, many works have been recognized, when a set of BRAND'S Essence of Chicken of the works nominated in the New York Advertising Festival, I was excited to play a afternoon, the phone, tell all they know people, so that everyone share in the joy. At that time, there is no a domestic advertising companies in the world have been winning it. ????Lin: 97 at the end, you go to Guangzhou, Saatchi & Saatchi as a senior copywriter. What made you leave the Saatchi & Saatchi, after half a year, once again a business? ????Zou: At that time, customers are to promote real estate properties for sale, I was one of the real estate owners, they intend to put this business to me. A rare opportunity, together with local and foreign companies have been working in the experience, and understand the company's basic mode of operation, so consult with a student to start a company took on the customers, while finding Xi Lu (now the British Young Legend CEO). ????Lu Xi is my line of duty after graduation assigned to the southern advertising company, at the beginning she did not want to participate because she was regarded as state cadres, have a higher and stable income, we always, always has been inciting her until she agreed to so far. Then each of the three of us hit some money, in the bead shadow over twenty square meters rented a small house, on April 18, 1998 set up the "Legend of Advertising Co., Ltd.", I was creative director, Lu Xi is the film Director, another colleague's president. Entrepreneurship is hard, and have up to six months, we did not receive in salaries, and then I was for the building, only a bicycle to work every day. But do we think makes sense, we are doing things in order to perfect and struggle hard to feel good. ????In addition to the real estate company, we have developed a number of clients, including µñÅÆ now has been done. We have been very grateful for such a bold Diaopai unknown only use a small company out. The result is a win-win, and we made a moving their advertising, they also helped us grow. ????Lin: Entrepreneurship is difficult, it did not happen during the occurrence of a number of interesting or memorable experience? ????Zou: I remember we want to shoot a television film Jin Gechuan Valley, it is our first television commercials, the creative aspects of the customer has passed. One day, Lu, general manager of the total went to Shenzhen and who sign up with them after signing a smooth, good call collusion cheat I said: "The client did not sign into the critical moment that customers do not want to do." I was one, is lost. They came back looking very low and depressed, but I have to console them, said: It does not matter, after plenty of opportunities. Suddenly the general manager took a large bag of something wrapped in a newspaper out, open to have a look, which is all cash, twenty-tens of thousands in cash. The first time I've ever seen so much cash, very shocked, excited everyone laughing behind closed doors. This is our first film, but so many customers at once to the cash, is a beautiful start. ????Lin: What a beautiful start, and now still think it sounds exciting, now, I am afraid that fewer such customer. It seems getting the company's operations on track, why think of merger with the British Young do? Among these, there's the challenge? ????Zou: Television advertising can be taken at that time was our strength, including P & G has taken a number of feature films, which both we and the British Young (Young British owner of the ad before I was a partner in the South Chun Yi, along with experienced short-lived business experience) into a cause. Ying Yang was doing P & G's advertising business, is considering restructuring, intended to expand the field in the media, trying to companies is divided into: advertising, programming, media three parts. This part of the advertising, out of our trust, hope and our proposed merger, spin-off this part of the business. ????For the merger, the shareholders have different views. Lu and I always thought that our original business, which is a single, the company developed to a certain degree of need for a higher level, this is a transition into a comprehensive agent-based advertising company a good opportunity, they have a good platform, but the original legend of the company The general manager has opposed the last disagreement, only separation. This is a very difficult choices in the process, full of risk. ????After separation, we set up the legendary Yang Ying Yang advertising. This took place in the middle of a very interesting thing. ????Merger, we require half and half with the British Young equity in the company name is called "Young British legend" or called "Young British legend?" No conclusions argue for a long time, the last British general said Huang Yang, as determined by lot. Thus, articles were written two words, the total first pumping Huang, Ying Yang, and he pumped legend, the company name to such a dramatic birth. ????After the establishment of Yang legendary British, I am the legal representative of the original Young British companies do not participate in corporate management, I insist that you do Xi Lu, general manager. The values of Xi Lu and I are very close, many decisions are often coincide, and we are tolerant to each other, encourage each other, the company toward a healthy direction. ????Lin: Along the way, you have been the first copy, creative director and company growth managers, creative people than many peers are farther out. ????Zou: the confusion experienced local companies, foreign companies experience, the hardships of pioneering in setting tough, experienced the organization more games, shareholders change, staff turnover ... ... In recent years, more often need to stand firm managers point of view to think about the future development of the company. ????Strength of an individual is limited, Xi Lu and I have been looking and looking for good people to participate in the development of the company. Later, the Ming (who is also my colleagues in the arts south Chun, Oh, life really is filled with drama) came in, and become one of the shareholders. Daming very good, and his cooperation is a pleasant thing. Many people will think hard mountain god, lord we chosen to break the stereotypes. Although he and I have very different personalities, but our values are very consistent with the mentality of doing things, plus we maintain regular communication and exchanges, so a lot of things dealing with them quickly and efficiently. ????Now we are three of cooperation, the "iron triangle" relationship. ????Lin: What is your ideal? ????Zou: proof of a great local company is also not doing worse than the international company, we need to create a legend for the local companies. ????P.5 ????Zheng Daming Legend: adherence to excellence ????After entering through the way the advertising industry ????Lin: I heard you are a "child prodigy", but also an "alien", why not? ????Cheng: I was a child studying at Shanghai Jiao Tong University Junior classes. Junior class is the so-called "child prodigy", have the people inside were high hopes, the best scientists can be accomplished. But later, on the industrial design department at when (laughs), he gave us a lesson - "Creation", and I'm like, then select the "industrial design" professional. Compared with other students, I was a heterogeneous, they are basically in the IT industry. ????Lin: You're a student of industrial design, why think of involved in the advertising industry? ????Zheng: graduation, China's industrial development started shortly after the needs of industrial designers is very small, the profession is relatively advanced, so can not find the right job. Was assigned to the tractor factory in Tianjin. Students have to work just one year internship was arranged to move the tire shop - there are one high tires. I am a person dissatisfied with a stable life, working not to a year, do not hold back any longer, did not wait to positive on the left, so I am not a state cadres, is a worker. (Laughs) ????To leave the tractor factory, one would like to advertise. No particular reason. If anything, there may be some of the ads seen in the college books, at that time to bury the seeds of advertising. Life is full of chance, of course, may also be related to my personality, I am a restless person. ????LAM: Do you think "industrial design" professional, how you help the cause of the future of advertising? ????Zheng: I think this ad is certainly professional and related, this relationship is the "beauty" and "create", that is, aesthetic and creativity. ????Lin: Please talk about your advertising growth experience. ????Zheng: I went to Guangzhou, the first company to work only 3 individuals, a small company. Who was quick money, to think: Who gave my first job, I will fully repay! After being hired, the company is small, there are no very clear division of labor, I am planning to do from a creative plan to write their own books, write their own copy, do graphic design, who is also the two sectors. (Laughs) at that time really go all out every day. Company also gave me a monthly salary up until the final rise, the boss said to me: "You go!" ????Yi Chun then went south Advertising Co., Ltd., can be said that the company is also the birthplace of Guangzhou, one of advertising. Guangzhou advertising industry was thriving, vibrant, very exciting, mainly because the country was in the digestion of Guangzhou advertising business, a lot of good customers, people have come to Guangzhou. Hui Zou was also in that company, we know at that time. Yi Chun in the South, I am also from the customer services, planning to achieve creativity. ????Worked out a business after the senior brand manager, made almost half a year. Corporate culture and advertising is very different, very complicated, and I pay more attention to things, do not want to spend too much time and energy in terms of personnel. Because a person's energy is limited, if you spend too much time in this regard, the work area relative to less energy, have little meaning. To do their own things to do. ????And then to director of strategy from the source to do is train, from the strategy has been to achieve creativity. I remember once, I go pitch, I am also a man to do creative strategy, and finally won. Later a contract, the check on a person are also I do. Oh ... ... ????LAM: Do you non-advertising majors in college, but full of confidence, confidence come from? ????Zheng: insight into the facts, then a simple way to show them creative ways. This may be related to mathematical logic I used to learn a relationship, things can boil down to a simple complex things. Mathematics has two main principles: induction, inference method. I feel that writing is, in fact, induction and reasoning. Ever-changing world, we must be able to find the essence of things. ????LAM: Do you think that strategy and creativity is what kind of relationship? ????Cheng: In my observation, many advertising strategy and creative touch, convergence is not enough, a lot of creativity on the strategy department of the Ministry of understanding enough, creative and sometimes do not consider the strategy, not better to understand the strategy, things will predictability is not enough. The strategy itself is also required to have ideas, be creative thinking. Strategy in the analysis, understanding of the process is rational, but in considering the response, creative when there are emotional elements in it, and even with the character is relevant. ????Lin: start their own company, business was also very sensual, why not continue to be the boss, instead focus on doing creative? ????Cheng: The company operating a few years later, I got thinking. I am a man not easily satisfied, and tired to start a company, do a lot of you do not want to do, can not concentrate to do well produced. I spent a year's time to think, in the end go on or off. Very painful. Finally, back to the most essential starting point, I asked myself a question: What is my favorite? Yes, creative. There is no doubt. I like to create a miracle, like to do difficult moves, like to do some spectacular things, it will inspire me a lot of enthusiasm. ????I turned off the company, resolutely. In many cases, you can not just money. Off company, I am determined to focus on advertising creativity. First went to the Blue Flame Advertising Co., Ltd., Guangzhou City, do ECD; 2004 years, the legendary British Yang, the company is in the form of creative partner invited me to come in, we have many common ideas. ????Lin: the future direction? ????Zheng: exciting stories! Exciting prizes! Exciting customers! The key is determined to do advertising. ????LAM: Do you think local companies than international companies with high levels of it? ????Zheng: Overall, this is fact. However, we are such a big country, do not own a decent advertising is not acceptable. ????Our generation has a relatively strong national consciousness, complex. Just like the challenge of its own, this time there will be spirit and passion. Of course, the process is not so simple because to promote a lot of change. ????LAM: Do you think the biggest international and local companies What is the difference? ????Cheng: First, international companies a good foundation, high starting point. In an international customer base, they were further expanding the local customer, would be relatively easy. Local company? That is the real start from scratch. ????Second, the brand effect. China's current stage, the blind Worship of the person, or a lot. ????Third, the concept of customer, customer maturity. International customers generally mature than local customers. ????However, local companies have the most powerful that we own this land are the growth of the consumer, we know this land and people. ????Lin: International influence on the local companies? ????Zheng: great. Inspired play, learn, learning effect. Learning good things: such as the rigorous processes. ????Lin: usually like to see the book? ????Zheng: I usually read a magazine, because there is no time to read novels. Political and economic class, like, such as "South Wind", "Joint Weekly." Military, history, astronomy, geography, science, and sometimes read gossip magazines. Encyclopedia bought for my daughter, I see. I think the ad should read the book the most is the encyclopedia. ????I will deliberately to focus on some things, such as comics, cartoons, especially the focus on art for the sake of fashion. Because advertising is a fashion art, you can not be 40 years of advertising out of the elements you must be at the time. ????Lin: your loved ones? ????Zheng: I now affects most of the people: his wife and daughter. ????If her daughter one day asked: "What do you do?" I would say: "I am dry ad." If you ask: "How you do?" I hope it is: "I did okay."
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24 years of experience
Accepting new patients
Ste 690
Las Vegas, NV 89109 Phone number & directions
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. William Castillo:
View the full profile to get information on:
- Qualifications
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Patient Reviews
The overall average patient rating of Dr. William Castillo is Excellent.
Specialties & Research
Dr. William Castillo, FACC, MD is board certified in Pediatric Cardiology.
Education & Awards
Dr. Castillo graduated from Universidad Del Valle, Cali, Melendez. He has 1 awards.
Dr. Castillo has 16 hospital affiliations:
- Southern Hills Hospital & Medical Center
- Spring Valley Hospital Medical Center
- Spanish
- English
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- Additional Information
- Dr. William Javier Castillo FACC and MD is a male Pediatric Cardiologist, has 24 years of experience and practices in Pediatric Cardiology.
- Where does Dr. William J. Castillo practice?
- Dr. William Castillo has 4 office locations.
Dr. William Castillo practices Pediatric Cardiology near Las Vegas, NV.
Additional practice locations include: Henderson, NV and Reno, NV.
See Las Vegas Pediatric Specialists.


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Ohio Governor's Police Panel Calls For More Oversight
A task force studying Ohio police and community relations has narrowed down list of potential recommendations.
Listen to the Story
Oftentimes crop farmers keep their heads down while walking a field. But at this year's Farm Science Review their eyes are on the sky. Ohio State aerospace engineer, Matthew McCrink is demonstrating unmanned aeriel vehicles or drones. The drones are equipped with high-resolution cameras to give literally a bird's eye view of field conditions. But, McCrink says first he had to get clearance to fly the seven pound contraption.
McCrink is an aerospace engineer at Ohio State University. He is demonstrating the drone during the annual Farm Science Review near London.
Click the LISTEN ICON to hear an interview with Matthew McCrink.


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The UGA Alumni Association is proud to present the Faculty Service, Alumni Family of the Year, and Alumni Merit awards.
With these awards, the Alumni Association expresses its deep appreciation for individuals who - through their service, contributions and accomplishments - bring distinction and honor to the University of Georgia, the state, nation and world.
The 2015 Alumni Awards Luncheon will take place on Friday, April 17 at noon in the Tate Student Center's Grand Hall. Registration will open soon.
2015 Alumni Award Honorees
Alumni Merit Award
C.L. Morehead, Jr. (BSA '50)
Alumni Merit Award
James H. Blanchard (BBA '63, LLB '65)
Young Alumni Award
Deep J. Shah (AB '08, BS '08)
Faculty Service Award
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Aquaponics is the integration of aquaculture and soilless culture in a closed production system. This manual details aquaponics for small-scale production--predominantly for home use. The manual is divided into nine chapters and seven annexes, with each chapter dedicated to an individual module of aquaponics.
This paper presents a portfolio of potential food wastage mitigation measures, illustrating the gross and net economic, environmental and societal benefits of each. Adopting appropriate food wastage mitigation measures can offer corresponding huge environmental benefits, leading to associated net gains for societies in terms of reduced economic losses and external costs. The performance of measures aiming at avoiding food wastage tends to be higher than for reusing, recycling of food products and certainly higher than landfilling.
This edition of FAO's State of the World's Forests report (SOFO 2014) addresses this knowledge gap by systematically gathering and analyzing available data on forests' contributions to people's livelihoods, food, health, shelter and energy needs. Crucially, the report also suggests how information might be improved and policies adjusted, so that the socioeconomic benefits from forests can be enhanced in the future.
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Publications (24)153.37 Total impact
Article: Three-dimensional structures of mutant forms of E. coli inorganic pyrophosphatase with Asp-->Asn single substitution in positions 42, 65, 70, and 97.[Show abstract] [Hide abstract]
ABSTRACT: The three-dimensional structures of four mutant E. coli inorganic pyrophosphatases (PPases) with single Asp-->Asn substitutions at positions 42, 65, 70, and 97 were solved at 1.95, 2.15, 2.10, and 2.20 A resolution, respectively. Asp-42-->Asn and Asp-65-->Asn mutant PPases were prepared as complexes with sulfate--a structural analog of phosphate, the product of enzymatic reaction. A comparison of mutant enzymes with native PPases revealed that a single amino acid substitution changes the position of the mutated residue as well as the positions of several functional groups and some parts of a polypeptide chain. These changes are responsible for the fact that mutant PPases differ from the native ones in their catalytic properties. The sulfate binding to the mutant PPase active site causes molecular asymmetry, as shown for the native PPase earlier. The subunit asymmetry is manifested in different positions of sulfate and several functional groups, as well as changes in packing of hexamers in crystals and in cell parameters.Biochemistry (Moscow) 07/1998; 63(6):671-84. · 1.35 Impact Factor
Article: Changes in E. coli inorganic pyrophosphatase structure induced by binding of metal activators.[Show abstract] [Hide abstract]
ABSTRACT: The three-dimensional structures of E. coli inorganic pyrophosphatase (PPase) and its complexes with Mn2+ in a high affinity site and with Mg2+ in high and low affinity sites determined by authors in 1994-1996 at 1.9-2.2 A resolution are compared. Metal ion binding initiates the shifts of alpha-carbon atoms and of functional groups and rearrangement of non-covalent interaction system of hexameric enzyme molecule. As a result, the apoPPase with six equal subunits turns after Mg2+ binding into the structure with three types of subunits distinguished by structure and occupance of the low affinity Mg2+ site. Induced asymmetry reflects the subunit interactions and cooperativity between Mg2+ binding sites. These molecular rearrangements are structural basis to account for special features of the enzyme behavior and to propose one of the pathways for enzymatic activity regulation of constitutive PPases in vivo.Biochemistry (Moscow) 06/1998; 63(5):592-9. · 1.35 Impact Factor
Article: Crystal structure of tryptophanase[Show abstract] [Hide abstract]
ABSTRACT: The X-ray structure of tryptophanase (Tnase) reveals the interactions responsible for binding of the pyridoxal 5'-phosphate (PLP) and atomic details of the K+ binding site essential for catalysis. The structure of holo Tnase from Proteus vulgaris (space group P2(1)2(1)2(1) with a = 115.0 A, b = 118.2 A, c = 153.7 A) has been determined at 2.1 A resolution by molecular replacement using tyrosine phenol-lyase (TPL) coordinates. The final model of Tnase, refined to an R-factor of 18.7%, (Rfree = 22.8%) suggests that the PLP-enzyme from observed in the structure is a ketoenamine. PLP is bound in a cleft formed by both the small and large domains of one subunit and the large domain of the adjacent subunit in the so-called "catalytic" dimer. The K+ cations are located on the interface of the subunits in the dimer. The structure of the catalytic dimer and mode of PLP binding in Tnase resemble those found in aspartate amino-transferase, TPL, omega-amino acid pyruvate aminotransferase, dialkylglycine decarboxylase (DGD), cystathionine beta-lyase and ornithine decarboxylase. No structural similarity has been detected between Tnase and the beta 2 dimer of tryptophan synthase which catalyses the same beta-replacement reaction. The single monovalent cation binding site of Tnase is similar to that of TPL, but differs from either of those in DGD.Journal of Molecular Biology 02/1998; 276(3):603-23. DOI:10.1006/jmbi.1997.1561 · 3.96 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: The three-dimensional structure of inorganic pyrophosphatase from Escherichia coli complexed with sulfate was determined at 2.2 A resolution using Patterson's search technique and refmed to an R-factor of 19.2%. Sulfate may be regarded as a structural analog of phosphate, the product of the enzyme reaction, and as a structural analog of methyl phosphate, the irreversible inhibitor. Sulfate binds to the pyrophosphatase active site cavity as does phosphate and this diminishes molecular symmetry, converting the homohexamer structure form (alpha3)2 into alpha3'alpha3". The asymmetry of the molecule is manifested in displacements of protein functional groups and some parts of the polypeptide chain and reflects the interaction of subunits and their cooperation. The significance of re-arrangements for pyrophosphatase function is discussed.FEBS Letters 07/1997; 410(2-3):502-8. DOI:10.1016/S0014-5793(97)00650-9 · 3.34 Impact Factor
Article: Crystal structure of holo inorganic pyrophosphatase from Escherichia coli at 1.9 A resolution. Mechanism of hydrolysis.[Show abstract] [Hide abstract]
ABSTRACT: Crystalline holo inorganic pyrophosphatase from Escherichia coli was grown in the presence of 250 mM MgCl2. The crystal structure has been solved by Patterson search techniques and refined to an R-factor of 17.6% at 1.9 A resolution. The upper estimate of the root-mean-square error in atomic positions is 0.26 A. These crystals belong to space group P3(2)21 with unit cell dimensions a = b = 110.27 A and c = 78.17 A. The asymmetric unit contains a trimer of subunits, i.e., half of the hexameric molecule. In the central cavity of the enzyme molecule, three Mg2+ ions, each shared by two subunits of the hexamer, are found. In the active sites of two crystallographically independent subunits, two Mg2+ ions are bound. The second active site Mg2+ ion is missing in the third subunit. A mechanism of catalysis is proposed whereby a water molecule activated by a Mg2+ ion and Tyr 55 play essential roles.Biochemistry 07/1997; 36(25):7754-60. DOI:10.1021/bi962637u · 3.19 Impact Factor
Article: Escherichia coli inorganic pyrophosphatase: Site-directed mutagenesis of the metal binding sites[Show abstract] [Hide abstract]
ABSTRACT: Aspartic acids 65, 67, 70, 97 and 102 in the inorganic pyrophosphatase of Escherichia coli, identified as evolutionarily conserved residues of the active site, have been replaced by asparagine. Each mutation was found to decrease the k(app) value by approx. 2-3 orders of magnitude. At the same time, the Km values changed only slightly. Only minor changes take place in the pK values of the residues essential for both substrate binding and catalysis. All mutant variants have practically the same affinity to Mg2+ as the wild-type pyrophosphatase.FEBS Letters 01/1997; 399(1-2):99-102. DOI:10.1016/S0014-5793(96)01296-3 · 3.34 Impact Factor
Article: The binding of carbon monoxide and nitric oxide to leghaemoglobin in comparison with other haemoglobins[Show abstract] [Hide abstract]
ABSTRACT: Haemoglobins have the ability to discriminate between oxygen and other diatomic molecules. To further understanding of this process the X-ray crystal structures of carbonmonoxy and nitrosyl-leghaemoglobin have been determined at 1.8 A resolution. The ligand geometry is discussed in detail and the controversial issue of bent versus linear carbon monoxide binding is addressed. The bond angle of 160 degrees for CO-leghaemoglobin is in conflict with recent spectroscopy results on myoglobin but is consistent with angles obtained for myoglobin X-ray crystal structures. In contrast to the numerous carbon monoxide studies, very little stereochemical information is available for the nitric oxide adduct of haemoglobin. This is provided by the X-ray structure of NO-leghaemoglobin, which conforms to expected geometry with an Fe-NO angle of 147 degrees and a lengthened iron-proximal histidine bond. Thus crystallographic evidence is given for the predicted weakening of this bond on the binding of nitric oxide.Journal of Molecular Biology 12/1996; 264(1):152-61. DOI:10.1006/jmbi.1996.0630 · 3.96 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: The three-dimensional structure of the manganese-phosphate complex of inorganic pyrophosphatase from Saccharomyces cerevisiae has been refined to an R factor of 19.0% at 2.4-A resolution. X-ray data were collected from a single crystal using an imaging plate scanner and synchrotron radiation. There is one dimeric molecule in the asymmetric unit. The upper estimate of the root-mean-square coordinate error is 0.4 A using either the delta A plot or the superposition of the two crystallographically independent subunits. The good agreement between the coordinates of the two subunits, which were not subjected to non-crystallographic symmetry restraints, provides independent validation of the structure analysis. The active site in each subunit contains four manganese ions and two phosphates. The manganese ions are coordinated by the side chains of aspartate and glutamate residues. The phosphate groups, which were identified on the basis of their local stereochemistry, interact either directly or via water molecules with manganese ions and lysine, arginine, and tyrosine side chains. The phosphates are bridged by two of the manganese ions. The outer phosphate is exposed to solvent. The inner phosphate is surrounded by all four manganese ions. The ion-binding sites are related to the order of binding previously established from kinetic studies. A hypothesis for the transition state of the catalytic reaction is put forward.European Journal of Biochemistry 08/1996; 239(1):220-8. DOI:10.1111/j.1432-1033.1996.0220u.x · 3.58 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Further refinement of X-ray data on Escherichia coli inorganic pyrophosphatase [Oganessyan et al. (1994) FEBS Lett. 348, 301-304] to 2.2 A reveals a system of noncovalent interactions involving Tyr55 and Tyr141 in the active site. The pKa for one of the eight Tyr residues in wild-type pyrophosphatase is as low as 9.1 and further decreases to 8.1 upon Mg2+ binding, generating characteristic changes in the absorption spectrum. These effects are lost in a Y55F but not in a Y141F variant. It is suggested that the lower-affinity site for Mg2+ in the enzyme is formed by Tyr55 and Asp70, which are in close proximity in the apo-enzyme structure.FEBS Letters 01/1996; 377(1):44-6. DOI:10.1016/0014-5793(95)01310-5 · 3.34 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: The leghaemoglobins have oxygen affinities 11 to 24 times higher than that of sperm whale myoglobin, due mainly to higher rates of association. To find out why, we have determined the structures of deoxy- and oxy-leghaemoglobin II of the lupin at 1.7 A resolution. Results confirm the general features found in previous X-ray analyses of this protein. The unique feature that has now emerged is the rotational freedom of the proximal histidine. In deoxy-leghaemoglobin the imidazole oscillates between two alternative orientations, eclipsing either the lines N1-N3 or N2-N4 of the porphyrin; in oxy-leghaemoglobin it is fixed in a staggered orientation. The iron atom moves from a position 0.30 A from the plane of the pyrrole nitrogen atoms in deoxy- to a position in the plane in oxy-leghaemoglobin while the Fe- bond distance remains constant at 2.02 A. The Fe-O-O angle is 152 degrees, as in human haemoglobin. The oxygen is hydrogen-bonded to the distal histidine at N epsilon 2-O1 and N epsilon 2-O2 distance of 2.95 A and 2.68 A, respectively. The porphyrin is ruffled equally in deoxy- and oxy-leghaemoglobins, due to rotations of the pyrrols about the N-Fe-N bonds, causing the methine bridges to deviate by up to 0.32 A from the mean porphyrin plane. The only feature capable of accounting for the high on-rate of the reaction with oxygen are the mobilities of the proximal histidine and distal histidine residues in deoxy-leghaemoglobin. The eclipsed positions of the proximal histidine in deoxy-leghaemoglobin maximize steric hindrance with the porphyrin nitrogen atoms and minimize pi-->p electron donation, while its staggered position in oxy-leghaemoglobin reverses both these effects. Together with the oscillation of the imidazole between the two orientations, these two factors may reduce the activation energy for the reaction of leghaemoglobin with oxygen. The distal histidine is in a fixed position in the haem pocket in the crystal, but must be swinging in and out of the pocket at a high rate in solution to allow the oxygen to enter.Journal of Molecular Biology 08/1995; 251(1):104-15. DOI:10.1006/jmbi.1995.0419 · 3.96 Impact Factor
Article: X-ray crystallographic studies of recombinant inorganic pyrophosphatase from Escherichia coli.[Show abstract] [Hide abstract]
ABSTRACT: An E. coli inorganic pyrophosphatase overproducer and a method for a large-scale production of the homogeneous enzyme are described. The inorganic pyrophosphatase was crystallized in the form containing one subunit of a homohexameric molecule per asymmetric unit: space group R32, a = 110.4 A, c = 76.8 A. The electron density map to 2.5 A resolution phased with Eu- and Hg-derivatives (figure of merit, = 0.51) was improved by the solvent flattening procedure ( = 0.77). The course of the polypeptide chain and the secondary structure elements, intersubunit contacts and positions of the active sites were characterized. Homology with S. cerevisiae inorganic pyrophosphatase structure was found.FEBS Letters 08/1994; 348(3):301-4. DOI:10.1016/0014-5793(94)00605-9 · 3.34 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Three-dimensional crystal structures of holo (ternary complex enzyme-NAD-azide) and apo NAD-dependent dimeric formate dehydrogenase (FDH) from the methylotrophic bacterium Pseudomonas sp. 101 have been refined to R factors of 11.7% and 14.8% at 2.05 and 1.80 A resolution, respectively. The estimated root-mean-square error in atomic co-ordinates is 0.11 A for holo and 0.18 A for apo. X-ray data were collected from single crystals using an imaging plate scanner and synchrotron radiation. In both crystal forms there is a dimer in the asymmetric unit. Both structures show essentially 2-fold molecular symmetry. NAD binding causes movement of the catalytic domain and ordering of the C terminus, where a new helix appears. This completes formation of the enzyme active centre in holo FDH. NAD is bound in the cleft separating the domains and mainly interacts with residues from the co-enzyme binding domain. In apo FDH these residues are held in essentially the same conformation by water molecules occupying the NAD binding region. An azide molecule is located near the point of catalysis, the C4 atom of the nicotinamide moiety of NAD, and overlaps with the proposed formate binding site. There is an extensive channel running from the active site to the protein surface and this is supposed to be used by substrate to reach the active centre after NAD has already bound. The structure of the active site and a hypothetical catalytic mechanism are discussed. Sequence homology of FDH with other NAD-dependent formate dehydrogenases and some D-specific dehydrogenases is discussed on the basis of the FDH three-dimensional structure.Journal of Molecular Biology 03/1994; 236(3):759-85. DOI:10.1006/jmbi.1994.1188 · 3.96 Impact Factor
Article: Crystallization and preliminary X-ray investigation of holotryptophanases from Escherichia coli and Proteus vulgaris.[Show abstract] [Hide abstract]
ABSTRACT: Crystals of Proteus vulgaris holotryptophanase have been grown by the hanging-drop technique using polyethylene glycol 4000 as precipitant in the presence of monovalent cations K+ or Cs+. Orthorhombic crystals (P2(1)2(1)2(1)) grown with Cs+ have unit cell parameters a = 115.0 A, b = 118.2 A and c = 153.7 A and diffract to 1.8 A. There are four subunits of the tetrameric molecule in the asymmetric unit. Native data have been collected to 2.5 A resolution. The 3.4 A data were collected from tetragonal crystals of Escherichia coli holotryptophanase grown under conditions described by Kawata et al. (1991). The molecular replacement solution for this crystal form has been found using tyrosine phenol-lyase coordinates. The correct enantiomorph is P4(3)2(1)2. There are two subunits in the asymmetric unit.Journal of Molecular Biology 02/1994; 235(2):783-6. DOI:10.1006/jmbi.1994.1033 · 3.96 Impact Factor
Article: Crystallization and preliminary crystallographic characterization of bacteriophage T4 baseplate protein encoded by gene 9.[Show abstract] [Hide abstract]
ABSTRACT: The structural protein, gene product 9 (gp9), of bacteriophage T4 controls baseplate expansion at the first steps of virus attachment onto its host bacterial cell with subsequent tail contraction. Gp9, which has an M(r) of 30.8 kDa and contains 287 amino acids, has been purified from a recombinant Escherichia coli strain and crystallized at 25 degrees C using the hanging drop vapor diffusion method at pH 4.0 with ammonium sulfate as precipitant. The crystals of gp9 belong to the space group R32 with hexagonal cell dimensions a = b = 86.5 A and c = 156.2 A and diffract X-rays to at least 2.7 A. There is one molecule per asymmetric unit.Journal of Molecular Biology 12/1993; 234(2):493-5. DOI:10.1006/jmbi.1993.1601 · 3.96 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Tyrosine phenol-lyase (EC 184.108.40.206) from Citrobacter freundii has been cloned and the primary sequence deduced from the DNA sequence. From the BrCN digest of the NaBH4-reduced holoenzyme, five peptides were purified and sequenced. The amino acid sequences of the peptides agreed with the corresponding parts of the tyrosine phenol-lyase sequence obtained from the gene structure. K257 is the pyridoxal 5'-phosphate binding residue. Assisted by the sequence data, the crystal structure of apotyrosine phenol-lyase, a pyridoxal 5'-phosphate-dependent enzyme, has been refined to an R-factor of 16.2% at 2.3-A resolution using synchrotron radiation diffraction data. The tetrameric molecule has 222 symmetry, with one of the axes coincident with the crystallographic 2-fold symmetry axis of the crystal which belongs to the space group P2(1)2(1)2 with a = 76.0 A, b = 138.3 A, and c = 93.5 A. Each subunit comprises 14 alpha-helices and 16 beta-strands, which fold into a small and a large domain. The coenzyme-binding lysine residue is located at the interface between the large and small domains of one subunit and the large domain of a crystallographically related subunit. The fold of the large, pyridoxal 5'-phosphate binding domain and the location of the active site are similar to that found in aminotransferases. Most of the residues which participate in binding of pyridoxal 5'-phosphate in aminotransferases are conserved in the structure of tyrosine phenol-lyase. Two dimers of tyrosine phenol-lyase, each of which has a domain architecture similar to that found in aspartate aminotransferases, are bound together through a hydrophobic cluster in the center of the molecule and intertwined N-terminal arms.Biochemistry 05/1993; 32(16):4195-206. DOI:10.1021/bi00067a006 · 3.19 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: The ternary complex of NAD-dependent formate dehydrogenase (FDH) from the methylotrophic bacterium Pseudomonas sp. 101 (enzyme-NAD-azide) has been crystallised in the space group P2(1)2(1)2(1) with cell dimensions a = 11.60 nm, b = 11.33 nm, c = 6.34 nm. There is 1 dimeric molecule/asymmetric unit. An electron density map was calculated using phases from multiple isomorphous replacement at 0.30 nm resolution. Four heavy atom derivatives were used. The map was improved by solvent flattening and molecular averaging. The atomic model, including 2 x 393 amino acid residues, was refined by the CORELS and PROLSQ packages using data between 1.0 nm and 0.30 nm excluding structure factors less than 1 sigma. The current R factor is 27.1% and the root mean square deviation from ideal bond lengths is 4.2 pm. The FDH subunit is folded into a globular two-domain (coenzyme and catalytic) structure and the active centre and NAD binding site are situated at the domain interface. The beta sheet in the FDH coenzyme binding domain contains an additional beta strand compared to other dehydrogenases. The difference in quaternary structure between FDH and the other dehydrogenases means that FDH constitutes a new subfamily of NAD-dependent dehydrogenases: namely the P-oriented dimer. The FDH nucleotide binding region of the structure is aligned with the three dimensional structures of four other dehydrogenases and the conserved residues are discussed. The amino acid residues which contribute to the active centre and which make contact with NAD have been identified.European Journal of Biochemistry 07/1992; 206(2):441-52. DOI:10.1111/j.1432-1033.1992.tb16945.x · 3.58 Impact Factor
Article: The polypeptide chain fold in tyrosine phenol-lyase, a pyridoxal-5'-phosphate-dependent enzyme.[Show abstract] [Hide abstract]
ABSTRACT: The tyrosine phenol lyase (EC 18.104.22.168) from Citrobacter intermedius has been crystallised in the apo form by vapour diffusion. The space group is P2(1)2(1)2. The unit cell has dimensions a = 76.0 A, b = 138.3 A, c = 93.5 A and it contains two subunits of the tetrameric molecule in the asymmetric unit. Diffraction data for the native enzyme and two heavy atom derivatives have been collected with synchrotron radiation and an image plate scanner. The structure has been solved at 2.7 A resolution by isomorphous replacement with subsequent modification of the phases by averaging the density around the non-crystallographic symmetry axis. The electron density maps clearly show the relative orientation of the subunits and most of the trace of the polypeptide chain. Each subunit consists of two domains. The topology of the large domain appears to be similar to that of the aminotransferases.FEBS Letters 06/1992; 302(3):256-60. DOI:10.1016/0014-5793(92)80454-O · 3.34 Impact Factor
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ABSTRACT: The crystal structure of thermitase, a subtilisin-type serine proteinase from Thermoactinomyces vulgaris, was determined by X-ray diffraction at 1.4 A resolution. The structure was solved by a combination of molecular and isomorphous replacement. The starting model was that of subtilisin BPN' from the Protein Data Bank, determined at 2.5 A resolution. The high-resolution refinement was based on data collected using synchrotron radiation with a Fuji image plate as detector. The model of thermitase refined to a conventional R factor of 14.9% and contains 1997 protein atoms, 182 water molecules and two Ca ions. The tertiary structure of thermitase is similar to that of the other subtilisins although there are some significant differences in detail. Comparison with subtilisin BPN' revealed two major structural differences. The N-terminal region in thermitase, which is absent in subtilisin BPN', forms a number of contacts with the tight Ca2+ binding site and indeed provides the very tight binding of the Ca ion. In thermitase the loop of residues 60 to 65 forms an additional (10) beta-strand of the central beta-sheet and the second Ca2+ binding site that has no equivalent in the subtilisin BPN' structure. The observed differences in the Ca2+ binding and the increased number of ionic and aromatic interactions in thermitase are likely sources of the enhanced stability of thermitase.Journal of Molecular Biology 08/1990; 214(1):261-79. DOI:10.1016/0022-2836(90)90160-N · 3.96 Impact Factor
Article: Thermitase and proteinase K: a comparison of the refined three-dimensional structures of the native enzymes.[Show abstract] [Hide abstract]
ABSTRACT: We compare the three-dimensional structures of thermitase and of proteinase K determined by X-ray crystallography to a resolution of 1.4 and 1.48 A respectively. Both enzymes are relatively stable towards heat and denaturating agents and are representative of a subgroup of subtilisins characterized by a free SH group close to the active site histidine. Even though they have low sequence homology, the overall tertiary structures are highly conserved. The high resolution structures are compared in terms of the overall fold of the molecules, the active sites, the calcium binding sites, disulphide bridge positions, the positions of the charged residues and the solvent structure. Most subtilisins such as thermitase are of prokaryotic origin and proteinase K is up to now the only known eukaryotic structure.Protein engineering 02/1990; 3(3):161-72. DOI:10.1093/protein/3.3.161
Article: A crystallographic station for structural investigations of macromolecular crystals on the synchrotron beam of the VEPP-3 storage ring[Show abstract] [Hide abstract]
ABSTRACT: A station designed to speed up the collection of integral intensity data from protein and virus crystals is constructed on the synchrotron radiation beam of the VEPP-3 storage ring. A flat triangular Si crystal cut at 8° relative to the (111) plane is used to monochromatize the radiation. A conventional Arndt-Wonacott rotation camera is used to collect structural information. The station also includes an optical bench which can turn about the axis coinciding with that of the monochromator, and a set of slits to cut the background and to form the beam. The ionization chamber serves to adjust the monochromator and to monitor the beam. Numerical results of first measurements from protein crystals as well as plans for future work are presented.Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 10/1989; 282(2-3):510-515. DOI:10.1016/0168-9002(89)90035-1 · 1.32 Impact Factor
Top Journals
Lomonosov Moscow State University
Moscow, Moscow, Russia
- Faculty of Chemistry
Russian Academy of Sciences
Moskva, Moscow, Russia
- • Institute of Crystallography
- • Institute of Molecular Biology
Институт молекулярной биологии им. В.А. Энгельгардта Российской академии наукMoskva, Moscow, Russia
Deutsches Elektronen-SynchrotronHamburg, Hamburg, Germany


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If you've got 15 minutes
Reach out to your child's class parent and volunteer to send reminder e-mails for events, meetings, field trips, parties, or fund-raising. You can be a hero just for sending those e-mails from your phone while sitting in a carpool line!
Should candy vending machines be removed from the school cafeteria? Is the science lab hopelessly outdated? Do kids need bike racks or crossing guards so they can ride or walk to school? When something needs changing at home or at work, you speak up, right? So set up an appointment for a short meeting or phone call with the school's principal and let him know how you feel.
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If there's something going on at your school that the community needs to know about, contact the local media. Send an e-mail or call a reporter at your newspaper, radio station, or TV channel if there's an issue you think could benefit from more public awareness and involvement. Or tell them about interesting classroom projects or student accomplishments—everyone loves a feel-good story.


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Book your room at The Afton House Inn
Standard RoomMax Occupancy: 2 guests (up to 1 child)
Jacuzzi Fireplace RoomMax Occupancy: 2 guests (up to 1 child)
Walkout RoomMax Occupancy: 2 guests (up to 1 child)
Executive SuiteMax Occupancy: 2 guests (up to 1 child, 1 infant)
River Jacuzzi RoomMax Occupancy: 2 guests (up to 1 child)
Riverfront bed & breakfast with free breakfast and restaurant
Located in the heart of Afton, this bed & breakfast is within 9 mi (15 km) of Afton Alps Ski Area, Afton State Park, and Seasons on St. Croix Gallery. Phipps Center for the Arts and StoneRidge Golf Club are also within 9 mi (15 km).
Property Features
This bed & breakfast features a restaurant, a bar/lounge, and conference rooms. Free continental breakfast and free self parking are also provided. Additionally, meeting rooms, concierge services, and wedding services are onsite.
Room Amenities
All rooms are individually decorated and offer phones and desks. Coffee makers and cable TV are among the other amenities that guests will find.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
The bed & breakfast offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. Guests can enjoy a complimentary breakfast.
Event facilities include conference space and meeting rooms. Onsite self parking is complimentary.
- Bar/lounge
- Concierge services
- Free breakfast
- Conference space
- Meeting rooms
- Total number of rooms - 25
- Restaurant
- Free self parking
- Wedding services
Free self parking
Room Amenities
- Air conditioning
- Private bathroom
- Cable TV service
- Individually decorated
- Coffee/tea maker
- Desk
- Phone
Where to Eat
Guests are offered complimentary continental and full breakfasts.
The Afton House Inn has a restaurant serving breakfast only.
Nearby Things to Do
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Hiking/biking trails nearby
- Sailing nearby
- Cross-country skiing nearby
- Downhill skiing nearby
Hotel Policies
Check-in time starts at 2 PM
Special check-in instructions:
Check-out time is 11 AM
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Extra-person charges may apply and vary depending on hotel policy.
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Foreign Relations: Regionalism as an Essential Mechanism
Academic journal article Southeast Asian Affairs , January 1, 2001
Article excerpt
In general, the Thai voting public are not interested in foreign relations, nor do they regard themselves as being affected by foreign policy decisions. The current economic crisis has made the public more aware of the role of international financial institutions in their daily lives. Unpleasant activities from Myanmar's dissidents in Thailand are other events that may stir their interest in foreign affairs from time to time. However, foreign relations are still perceived by the majority of Thais as an élite task that is far beyond the understanding of laymen. Foreign policy was not an issue in the 2001 general election.
The Chuan government was fortunate to have Dr Surin Pitsuwan and M.R. Sukhumbhand Paribatra as, respectively, the minister and the deputy minister of foreign affairs. Prior to entering the political arena, both had accumulated respect as outstanding academics in the field of international relations. They both have extensive networks with regional and international élites and institutions. With the application of theory to practice, both of them have given Thai diplomacy a high reputation. As a Muslim, Surin was able to pursue a close link with Islamic countries. Both Surin and Sukhumbhand have successfully implemented a proactive approach to ASEAN and to co-operation with the international community. Thailand played a leading role in establishing the agendas for both conventional and human security in the Southeast Asian region through the ASEAN Regional Forum (ARF) and the ASEAN Ministerial Meeting (AMM), as well as other venues. Thailand joined the International Force for East Timor (INTERFET), assuming the deputy command under Australia, in order to keep the regional peace and security, and in respect of the non-intervention principle. Thailand continues to stand by the enlargement of ASEAN membership, especially the controversial acceptance of Myanmar as a member, and will continue its efforts to urge political change in Myanmar. Moreover, Thailand contributed its effort to co-ordinate the ASEAN-Europe Ministerial Meeting (ASEM) held in Vientiene in late November 2000. This meeting had been postponed for more than two years because of the European Union's displeasure with Myanmar's dictatorial military regime, which engages in massive forced labour and generally has a dismal human rights record. In order to prevent the spillover of domestic conflict from neighbouring countries (especially from Myanmar with which Thailand shares its longest border), Surin had proposed a "flexible engagement" policy several years earlier. This was designed to allow for greater discussion of transnational issues in ASEAN. …


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Sou uma pessoa engraçada, trabalhadora, carinhosa que ama seus hobbys.
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29 • Belo Horizonte, Brazil • Man
I'm looking for
- Women
- Ages 18–40
- Near me
- Who are single
- For new friends, long-term dating, short-term dating, casual sex
My details
- Last online
- Oct 14, 2014
- Orientation
- Straight
- Ethnicity
- Hispanic / Latin, White
- Height
- 5′ 6″ (1.67m)
- Body type
- A little extra
- Diet
- Mostly anything
- Smokes
- When drinking
- Drinks
- Often
- Drugs
- Never
- Religion
- Christianity, but not too serious about it
- Sign
- Sagittarius, but it doesn't matter
- Education
- Graduated from masters program
- Job
- Sales / Marketing
- Income
- $30,000–$40,000
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- Doesn't have kids, but might want them
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- English (Fluently), Portuguese (Fluently)
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What I'm doing with my life
Don't overthink this one; tell us what you're doing day-to-day.
Tentando construir uma empresa sólida
I'm really good at
Go on, brag a little (or a lot). We won't judge.
Comunicação digital, música e umas outras coisinhas.
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I'm an empty essay… fill me out!
Que sou sério, mas ao mesmo tempo engraçado. Não sou de falar muito. Sou dedicado.
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Help your potential matches find common interests.
A série da Torre Negra de Stephen King,
muuuuitos filmes, todas as vertentes do rock, e show com certeza do Paul McCartney
muuuuitos filmes, todas as vertentes do rock, e show com certeza do Paul McCartney
The six things I could never do without
Think outside the box. Sometimes the little things can say a lot.
- Música
- Carinho
- Dinheiro
- Sexo
- Diversão
- Trabalho
- Carinho
- Dinheiro
- Sexo
- Diversão
- Trabalho
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Global warming, lunch, or your next vacation… it's all fair game.
A vida
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Netflix and takeout, or getting your party on — how do you let loose?
onde me sentir melhor.
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Tue December 16 2014
Tue December 16 2014
ABA Christmas Party
Events , ABA Events The ABA's Christmas Party will be held on Tuesday 16th December at our offices in the Arab British Chamber of Commerce Building, 43 Upper Grosvenor Street. Tickets are £40 for both members and non members. The party will start at 5.30pm and there will be entertainment and raffle prizes (so don't forget to bring your ticket with you!). Tickets can be booked through this website or through the ABA's offices: phone 020 7659 4889. We will post more details about the party on this website, as they become available.


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Eden Sands, Ocho Rios is a privately owned villa ideally located in the centre of town. Eden Sands boasts its own private white sand beach. Eden Sands is located next to Neptune Villa.
Space where guests can cook their own meals
In the building, free or for a fee
Space where guests can cook their own meals
Towels, bed sheets, soap, and toilet paper
Central heating or a heater in the listing
In the building, free or for a fee
In the building, free or for a fee
Continuous access in the listing
Breakfast is provided.
The listing can accommodate a gathering of 25 or more attendees
Easy access to the building and listing for guests in wheelchairs
Private or Shared
Free, in the building or nearby
Posted emergency information and resources
The Space
Eden Sands is a true Jamaican treasure, our villa has its own private beach and is located next to Neptune Villa. The perfect honeymoon or family spot that will create unforgettable memories. Centrally located walking distance from the town center and minutes away from all major tours and attractions.
This cottage boasts a perfect white sand beach 10 ft from your porch. Our open concept villa makes you feel like you are one with the amazing blue sea. A hundred (100) yards from the beach is the best for reef snorkeling and kayaking. Your host, Ms. Barbara, will enjoy each opportunity to show off her culinary skills. We encourage you to send a list of fruits, beverages and groceries, settle after arriving. The property comes with high speed internet together with an alarm system and a watchman from 6am-6pm.
Wireless internet, cable TV, air conditioners, charcoal grill, Samsung blue ray stereo system, 46 inch Samsung HD Flat Screen, washer, dryer, alarm system, tiki torches (on request). Within minutes to major attractions Dunn's River Falls, Mystic Mountain, Dolphin Cove.
Our service is provided with dignity and professionalism.
Our hosts, Nathan and Melissa were warm and friendly and very responsive to our many questions when preparing for our trip to Jamaica. They both visited with us during our trip and were available by phone to answer any questions or give recommendations. The villa was simple and perfect. There was always a cool breeze coming off the sea through the main entrance of the house and with the ceiling fans, there was no need for air conditioning. Both bedrooms had excellent air conditioning systems however, so we used those on just a few nights when the restaurant down the road had music playing - couldn't hear a thing with the windows closed. We felt very safe in the home and out and about in Ochi, which was an initial concern of ours. It was quickly dismissed after going out with Ms. Barbara around the town for a "tour". Milo (and Kirk - who was very nice), the night security gentleman was wonderful, had many interesting stories and was very generous, bringing us mangos and fresh ackee. Ms. Barbara, our chef, was simply the best. She cooked amazing fresh Jamaican food, oriented us to the town and stores, taught me how to make some dishes, and was knowledgeable about nutrition and health. She even made my "green juice" for me in the morning. She knew the island and was quite helpful about how to get around and acclimate to being in JA. The sea was perfect for scuba and looks just like the pictures posted - we spent time snorkeling, swimming, watching the world cup on the large screen TV, playing soccer on the beach, reading and just relaxing and rejuvenating in the sunshine. The Knutsford Express bus took us to Kingston and back - would highly recommend it for traveling distances - very clean and comfortable.
We had a wonderful family vacation, my boys (11 & 16) loved it and felt it was way better than going to an all-inclusive resort - the food was CERTAINLY better! We hope to get back there soon - perhaps rent both Eden Sands and Neptune, the villa next door. Thank you to all those we met at Eden Sands Villa for a great Jamaica visit.


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Lyman volleyball team returns to state tourney
The Lyman High School girls' volleyball team is set to play in its second consecutive state tournament starting tonight.
Prior to reaching last year's Class B state tournament, the Raiders sat out of the tournament for 17 years.
Today, the No. 6 Raiders (24-8) play No. 3 Chester Area in the opening round of the Class B state tournament at 6 p.m. at the Huron Arena in Huron.
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Home » NewHampshire.com » Travel & Tourism » Merrimack Valley
Susan Dromey-Heeter's Budget Vogue: Joy on parade today in Dover
'Tis the first Sunday after Thanksgiving, which, with Black Friday now behind us, marks the true beginning of the season of joy. Sure, you're reading "Budget Vogue," but is that enough joy for the day? If you're like me, you'll want more: more fun, more pleasure, more joy.
I'm partial to today's Dover Holiday Parade because, well, I'll be marching alongside my cherubs from St. Mary Academy's Student Council and because I love the parade's theme: "A Christmas Wish."
And what is our Christmas wish? That no one gets gored or gashed by the bull. And that we all leave Central Avenue with feelings of joy and fun and the spirit of love that is this holiday season. And that we bring some happiness and laughter to our little town.
So, as we're inundated with ads assuring us that the only joy we'll find this season is in a new tablet, smartphone or toy, let's remember that simple cup of cocoa, that happy place that is a parade, that enthusiasm captured by a community of people, old and young, rich and poor, crazy and sane, all out for the same goals: to partake in the joy, to avoid getting gored by a bull, to cheer on an 11-year-old Santador.
Susan Dromey-Heeter's Budget Vogue column is published the first week of every month in the New Hampshire Sunday News. Email her at email@example.com.
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Please don't just drop them off
I am writing this to ask the public not to just drop off unwanted animals at HART after hours. In the past two weeks we have had two boxes of kittens and two dogs left.
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The class not only learned about the men, but the rigid criteria used to determine whether an act of heroism was high enough to qualify for the award.Comments
The field of candidates also includes Gov. Bill Haslam's top legal adviser, Herbert Slatery; Republican state Sen. Doug Overbey of Maryville; and courts administrator Bill Young of Brentwood.Comments
Graybeal said Whitson's arrest came after an SRO at David Crockett High School encountered the student. The child had signs of bruising around the neck and on the face consistent with an assault.Comments
A court security officer who resigned last month from the Hawkins County Sheriff's Office now faces charges of statutory rape.Comments
A Kingsport woman has been arrested for allegedly slashing the tires on her husband's pickup — as a means to "get back at him" for hurting her feelings — then unleashing the knife on him when he approached and tried to stop her.Comments
Prosecutors have said that in June 2012, William Seevers held at knifepoint a 44-year-old woman who had been hiking on the Gatlinburg Trail.Comments
Faced with deepening crises in the Middle East and Ukraine, President Barack Obama is putting the brakes on the notion that American military power can solve either conflict.Comments
J. Fred Johnson Stadium is a go for tonight. The expansion is essentially complete and fans will get their first look at the renovations tonight when Dobyns-Bennett hosts East Hamilton for the first home game of the 2014 football season.Comments
A Johnson City man faces more than a dozen charges of statutory rape by an authority figure, stemming from his alleged relationship with a student during his tenure as an assistant band director at Sullivan South High School in Kingsport.Comments
What started as a 90 day stretch in the Hawkins County Jail expanded to three years for a Kingsport woman who attempted to smuggle three pills into the jail earlier this year.Comments


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Neil DeGrasse Tyson: I Don't Think Bush Knew This
Related posts from Unreasonable Faith:
- Lester Ballard
I don't think Bush knew much at all. Apparently he didn't know Cheney and Rove had their hands up his ass for eight years.
- Rover Serton
I agree, See story below, isn't that Cheney with his hand up Bush's behind?
It is sad that Cheney will probably be dead before crimes against humanaity are brought and Bush is young enough to get the punishement (for being Cheneys puppet).
- Igor
You could fill a book the size of the bible with the stuff Bush doesn't know.
- http://www.rationalavenue.com Sourabh Tiwary
Of course, Dr. Tyson is right. Arabs at one time were forerunners in astronomy, medicine, philosophy, chemistry…So, what has happened now? Why do we see the Arab countries failing. It was because of the impact of radical islam preached by Al-Ghazali in Arabia. This is an extreme example of what religion can do to impede progress.
- Marc Forrester
The religion is more symptom than cause, the Arab civilisation fell when Genghis Kahn's horde swept through the region burning every major city to the ground, leaving only crazy hill folk to repopulate the countries.


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Helmerich & Payne ReviewsHelmerich & Payne 25
"Great company to work for in the drilling field "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Culture & Values
- Career Opportunities
I have been working at Helmerich & Payne full-time (more than 3 years)Pros
Good benefits great pay good people to work with. They take care of there rigs. They advance in the company and all ways have openings for new employees.Cons
They don't really take care of there employees very well. They bump people back for no reason . They have a high turn over rate.RecommendsNeutral Outlook
Helmerich & Payne Interviews
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
- Application Details
I applied in-person. The process took a day – interviewed at Helmerich & Payne in June 2014.Interview Details
There really wasnt one. I was mislead about wage - 3 dollars less, per diem-none, and the location of the work. The drug screen and physical were done in an off site location in mass.Interview Questions
Accepted OfferNeutral ExperienceEasy Interview
- Do you have steel toe boots? View Answer
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Helmerich & Payne's core business is the drilling of oil and natural gas wells for exploration and production companies. They own and operate the largest land fleet of AC drive drilling rigs in the world. For more information, visit www.hpinc.com.


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Man of Steel Photo Gallery
A young boy learns that he has extraordinary powers and is not of this Earth. As a young man, he journeys to discover where he came from and what he was sent here to do. But the hero in him must emerge if he is to save the world from annihilation and become the symbol of hope for all mankind. View photos from Man of Steel…
Roll your mouse over the left and right-hand sides of the image and then click to view more pictures.
18 of 18
Watch the latest trailer for Man of Steel or view character posters
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