text:
Buffalo Bore Ammunition 38 Special 158 Grain Lead Semi-Wadcutter Hollow Point Box of 20
You must be 21 years or older to order ammunition. Ammo must ship UPS ground. Due to Department of Transportation regulations, we cannot accept returns on ammo. Please check local laws before ordering.
Product Information
Owner of Buffalo Bore Tim Sundles on Buffalo Bore Heavy 38 Special Ammunition:
Due to customer demand, we've developed this defensive 38SPL ammo. Our customers wanted some devastating 38SPL loads that would fill the following criteria.
1. It won't hurt older/fragile/alloy revolvers. (Non +P)
2. Is effective as a "fight stopper" through the use of proper bullets.
3. Is more powerful than typical/standard, weak 38SPL ammo.
4. Generate much less recoil than our +P 38SPL ammo.
5. Is flash suppressed.
Buffalo Bore is introducing these three different heavy, yet standard pressure loadings for 38 SPL. These offerings are loaded at standard pressure, but they are much more powerful than normal 38SPL ammo. These loads will not harm older more fragile revolvers. So, these loads are safe for use in ANY 38 SPL revolver, provided it is in normal working condition. As stated above, the "POWER" level of these loads is really closer to a typical +P power level, but the pressure is standard. We are able to develop these powerful standard pressure loads with modern non-canister powders. Again, these loads recoil far less than our +P 38 SPL ammo.
All three of these loads are flash suppressed, so firing them in the dark wont blind you. We use flash suppressed powder in our defensive ammo, in the loadings we can, because over 90% of all civilian shootings in America, occur in low light, when the criminal element is at work. We don't want you blinded by your own gunfire after the first shot.
Item 20C utilizes the same 158gr. very soft lead cast, SWC-HC gas checked bullet, we load in our +P 38 SPL ammo. It is designed to expand and then penetrate quite deep. (Approx. 14 inches) This bullet is gas checked and will NOT lead your barrel. Note the below velocities that I recorded out of my personal revolvers- NOT TEST BARRELS!
Technical Information
Ballistics Information:
Delivery Information
The total weight of the product, including the product's packaging as it sits on our shelf. Since some products ship directly from the Manufacturer, their weight may be unavailable. Because of variations in the manufacturing process, similar products may have differing weights. Unless the product is designated as "Ships Alone", Shipping Weight does not include the shipping box or packing materials associated with your order.
Product ships from MidwayUSA, separate from any other products on your order due to its size. Products that are Shipped Alone incur separate "Per Order" and "Per Pound" shipping charges.
Product is regulated by the US Department of Transportation (DOT) and cannot be shipped via USPS or air shipping methods. DOT-Regulated products must ship UPS Ground.
Product is restricted by shipping carriers and cannot be shipped to certain locations or via certain shipping methods.
- Cannot ship via air
- Cannot ship via USPS
- Cannot ship to PO Box
Additional shipping charge for HazMat products. Carriers charge extra to ship packages with products they consider hazardous, such as reloading powder and primers.
Thank you! Your valuable input helps improve our product information and future product selections
Customer Reviews
The statements and opinions expressed within Customer Reviews reflect each author's personal perspective and do not imply endorsement by MidwayUSA, its Employees or any other organization. Customers should in no way infer that MidwayUSA has validated review information as safe, accurate or appropriate.
We reserve the right to correct typographic, photographic and/or descriptive errors.
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text:
Spring driving tip: Check your lights. Rain hinders driving visibility, so make sure all your lights are plenty bright. http://ow.ly/L2LaZ
Add a comment...
650 Davis Street San Francisco, CA 94115
At Esurance, we want you to love your insurance in the same way you love your phone or your on-board navigation system…because it helps simplify your life. From personalized quotes to a full suite of discounts, Esurance makes it easy to save on coverage options that are right for you. Not someone sorta like you. And hey, welcome to the modern world.

subset: commoncrawl


text:
Successful candidates will be energetic, passionate, creative and patient.
You will assist with the planning, organization, implementation and delivery of a program based on the educational, social and emotional potential of the children enrolled.
You will assist in managing and creating the classroom environment, providing input and observation concerning program participants.
Candidates must have a high school diploma or GED and be GLQ and pursuing an AA in ECE. Bilingual (English/Spanish) applicants are encouraged to apply.
To learn more about this position and how to apply go to <http://www.connectingcolorado.com/>.
You can use the "Quick Search" feature, and key in job order number 5444519 for the Infant/Toddler Teacher position. For a complete list of jobs on the Colorado Department of Labor and Employment's website and free job search services you will need to register. This is a secure government site.
(KUSA-TV © 2012 Multimedia Holdings Corporation)


text:
Things to see and do - Royan
Leaving for France
Royan :
Unmissable tourist sites
Where to sleep?
Royan Hotel tips
Atlantis from51 €Book
Les Embruns from63 €Book
Abacus Hôtel from37 €Book
Royan Travel guide
Royan : Michelin's recommendations
After the bombings of 1945, hardly anything of the capital of the Beautiful Coast remained...If you did not include its magnificent beaches. Today a modern town has replaced the great hotels, the villas and the chalets that the old inhabitants of Royan talk about nostalgically and were what Jacques Henri Lartigues made immortal. But the town has recovered its fortunes. It is true though that with its location at the mouth of the Gironde, it would have been hard to do otherwise.
Tourist attractions Royan : Things to see and do
La Grande Côte
F - 17200 Royan
Leave the car at the point where the D25 from Royan ceases to follow the coastline and head into the woods to access a stony platform. The Gironde, Grave Point, Cordouan Lighthouse, Coubre Point and its lighthouse make for an impressive panorama. To ..
Sea front
bd Aristide-Briand F - 17200 Royan
The majestic Royan sea-front is both residential and commercial and runs along the Grande Conche, in front of an immense 2km beach. The front ends at the port which is accessible to trawlermen and pleasure boats. On the front you can see the outline ..
Church of Notre Dame de Royan
1 r. Foncillon F - 17200 Royan
This church in reinforced concrete covered in a layer of resin was built in 1958 by Guillaume Gillet and Hébrard. Note how the chevet seems to bow as you look up - an effect accentuated by the 65m-high bell-tower. On the left is a pyramid-shaped bapt..
Hotels Royan
Rêve de Sable
10, place du Marechal Foch F - 17200 Royan
Prix Prices from : 64 €
Rêve de Sable is located in Royan, just 60 metres from the town's beach, 20 metres from the beach and a 10-minute walk from the marina. The hotel has a seaside-themed décor and free Wi-Fi access is available. Each room also includes a flat-screen TV..
Les Embruns
18 bis Boulevard Garnier F - 17200 Royan
Situated 600 metres from the Royan Balnéotherapy Centre, Les Embruns boasts a prime beachfront location, facing the ocean and is just a 20-minute drive from La Palmyre Zoo. It offers modern accommodation and a daily breakfast buffet. Guest rooms at ..
32 avenue de la grande Conche F - 17200 Royan
Situated in a quiet area of Royan City Centre, this nautical-themed hotel is just 100 meters from the beach. It offers a garden with a private terrace. Guest rooms at the Atlantis hotel are stylishly decorated rooms, and have a private bathroom. The..
Restaurants Royan
6 allée des Rochers F - 17200 Royan
Les Filets Bleus
14 r. Notre-Dame F - 17200 Royan
This restaurant is dedicated to seafood and decorated in a nautical style (blue and white hues, anchors, port holes, hurricane lamps). Naturally there is a fish tank, and during the season, lobster takes pride of place. A bumper catch.


text:
£146.67 per 100ml
Item in stock
Opium Eau De Toilette vaporisateur 30ml
Item No.1230649300
Opium has a fruity and aromatic opening. A flowery and voluptuous character. A rich, oriental and spicy structure.
This item is available for
UK Home Delivery Free (UK orders over £30) or £3.99
Delivered within 4 working days
Next or Named Day Delivery
7 days a week between 8am - 6pm
Monday to Friday - order by 7pm - £4.99
Saturday & Sunday - order by 6pm - £4.99
Next or Named Evening Delivery
7 days a week between 6pm - 10pm
Monday to Sunday - order by 10pm - £6.99
Collect from store the next day - FREE
Order before 7pm for next day collection after 12pm midday
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Full Delivery details
Opium Eau De Toilette from Yves Saint Laurent.
- Free gifts are while stocks last. Gift is out of stock if not added to bag & NOT valid if used with a discount promo code
- 30ml


text:
What are the tubes going from the carboys into a bucket for?
Blow off tubes so if something ferments crazy you dont end up with mess city.
Blow off tubes prevent this from happening:http://imgur.com/5anxo
I had to look up what the definition of that word was. Cool beer name.
Yes. I learned about it in Prague.
It means to throw someone out of a window, usually to their death, but sometimes just seriously injured. It happened a bunch in Bohemian history and was an easy way to deal with councilmen and religious leaders they didn't like.


text:
Penn State football headlines Pa. year in sports
They did get to claim in-state bragging rights, at least, after a first-round playoff win over the odds-on Stanley Cup favorite Penguins.
Instead of worrying about the power play, Penguins star Sidney Crosby is simply worried about just playing. The 2007 MVP, limited to just 28 games since January 2011 because concussions, is now healthy and thinking about skating in Europe with the labor dispute still shutting down the NHL.
"I just want to play hockey," Crosby told reporters after an informal workout with some of his teammates this month.
On the hardwood, the Philadelphia 76ers had a successful 2011-12 season with their first winning record in seven seasons. They also took a playoff series for the first time since 2003 by knocking off the top-seeded Chicago Bulls, raising hopes for the future.
The Sixers then traded for 7-foot center Andrew Bynum in a multi-team deal that sent All-Star forward Andre Iguodala to Denver. But Bynum has yet to suit up in Philly because of injuries to each of his knees.
In college basketball, Big East powers Villanova and Pittsburgh each had disappointing seasons to snuff out long streaks of NCAA tournament appearances. Temple did make the NCAAs for a fifth straight year but fell to 12th-seeded South Florida in the second round.
No, this year's NCAA darlings resided in Bethlehem, where 15th-seed Lehigh beat second-seeded Duke in a second-round stunner. The win made the Mountain Hawks the new standard-bearers for upsets in the brainy Patriot League, pushing aside in-state rival Bucknell's takedown of Kansas as a No. 14 seed in the 2005 tournament.
In women's basketball, Penn State returned to Big Ten prominence after winning the regular-season league title for the first time since 2004. The Lady Lions are a mainstay in the Top 25 once again under coach Coquese Washington.
Penn State's also building a dynasty on the wrestling mat, where head coach and Olympic gold medalist Cael Sanderson led the Nittany Lions to a second consecutive national title in March.
At the race track, Jeff Gordon and Joey Logano each won a NASCAR race at Pocono — but the northeastern Pennsylvania tri-oval made just as much news away from the pits.
Joseph Mattioli, the founder and chairman of Pocono Raceway, died in January at age 86 following a lengthy illness. One fan died and nine others were hurt by lightning strikes in the raceway parking lot after the August race won by Gordon.
In November, IndyCar announced it was returning to Pocono in 2013 following a 23-year absence.
Back on the football field, Steve Addazio followed up his 9-4 season in his first year as Temple's coach in 2011 with a 4-7 record — then bolted for Boston College. Not even the Owls' move back to the Big East could keep Addazio from taking a job with an Atlantic Coast Conference school.
Like Addazio, Pitt is also leaving the Big East for the ACC next season. And it appears that first-year coach Paul Chryst, a former Wisconsin assistant, will shepherd the Panthers into its new league after Wisconsin athletic director Barry Alvarez signaled this month that he wouldn't pursue Chryst for the Badgers coaching job.
Chryst has also said he's committed to Pitt. The Panthers finished 2012 at 6-6 and received a bid to play in the BBVA Compass Bowl a third straight year, this time against Mississippi.
A bowl game is something that Penn State can't attain for another three years. Challenges surely remain, too, with scholarship cuts seemingly forcing O'Brien to rely more on walk-ons to fill depth.
But on the field, at least, O'Brien seems to have restored order to a program during a remarkable season of change.
Follow Genaro Armas at http://twitter.com/GArmasAP
AP Sports Writer Steven Wine in Miami contributed to this report.


text:
Dave Powell Becomes New Prescot Manager
By David Hills-Taylor, 21st May 2012
It has been confirmed that first team coach Dave Powell has left the club to take up the managerial vacancy at Prescot Cables FC.
Powell joined the club two years ago to join Danny Johnson's backroom staff as first team coach, and last season took on the role of head of player development, working closely with the Ashton United Development Squad.
He revealed that it was a tough decision to leave but having had previous managerial experience at Ashton Athletic he felt that this was a good opportunity for him to get back into management at a good standard of the game.
Ashtonutd.com would like to thank Dave for all his hard work whilst at the club and wish him well in his new role at Valerie Park.


text:
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text:
I have had this machine for several years and love it. I am looking to purchase one for my daughter. Is this machine NEW or refurbished? Also, mine has the dual feed device. Is this standard on all 6600 memorcraft machines?
A very good machine; smooth and easy to handle. Love how it sews. Only wish it had new button to sew without the foot pedal, but it is a wonderful machine. I would highly recommend this machine....
Janome Memory Craft 6300P Professional Sewing & Quilting Machine
- Details
- Shipping & Returns
- Reviews
- Sixty-three stitches
- Four (4) buttonholes
- LCD screen
- Maximum sewing speed: 1,000spm; 700spm zig zag
- Speed control slider
- Arm and bed space: 9 inches x 5 inches
- Visible pressure gauge
- Jam-proof, magnetic, top-loading full-rotary hook system
- Independent motor for bobbin winding
- Automatic thread cutter with memory capability
- Front access feed dog up/down
- Adjustable stitch width from 0-7mm
- Adjustable stitch length from 0-5mm
- Individual stitch editing including elongation
- Memory capability
- Auto-lock, needle up/down quick command keys
- Vertical thread delivery system with buil-in thread guide bar
- Built-in needle threader
- Extra-high presser foot lift
- Twin needle guard
- Knee lift
- 10 standard feet
- Large extension table
- Electronic foot control
- Sewing light
Accessories included:
- .25 seam foot
- Blind hem foot
- Cording foot
- Even feed foot
- Overcast foot
- Overedge foot
- Satin stitch foot
- Zipper foot
- Darning foot
- Hemmer foot
- Open toe satin stitch foot
- Buttonhole foot
- Extension table
- Bobbins
- Needles
- Cloth guide
- Knee lifter
- Quilt Brush
- Quilter Guide
- Screwdriver
- Seam ripper
- Spool holder (large)
- Spool holder (small)
|See description
|Manufacturer Warranty
|25 year Limited Manufacturer
|Aluminum die cast frame
|Model Number
Product Reviews
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Janome Memory Craft 6300P Professional Sew & Quilt
A very good machine; smooth and easy to handle. Love how it sews. Only wish it had new button to sew without the foot pedal, but it is a wonderful machine. I would highly recommend this machine.Read More
Questions & Answers
Hello kerryjoho, this machine is new. I could not find that this has dual feed. Have a great day!
does this machine have the extra removable elongated table ?
Hello quiltingnancy, this machine is so much fun to work with! Yes, this item comes with the large extension table. I hope this information helps. Thanks for shopping with us.
Is this a high shank machine?
This is not a high-shank machine.
Thank you for shopping with us mistyroses. This is standard for this type of machine. Have a great day.
Does this machine have a free arm?
Thank you for your question. This item does not have a free arm. Have a nice day!
does this machine have a built in even feed system?
This machine does not have the Janome built in Accufeed system, but you a Walking foot can be used to achieve the desired effect. Please let me know if you have any further question.
How wide is the throat of the machine?
What country is this machine made in?
This item was made in Taiwan.
This item was made in Taiwan.
Does this have a built in quilting foot or is a separate quilting foot available?
As standard accessories, this machine comes with an Even Feed Quilting foot, and a free motion quilting foot (darning foot). It also comes with 10 other feet, a knee lift, and various other accessories.
Shopping Guides
How to Choose a Serger
Unlike traditional sewing machines, sergers cut fabric and overlock seams as you sew. Sewing sergers provide professional edges with little effort compared to traditional sewing, and some sewers like overlock machines for adding decorative trims, making rolled hems and sewing elastic. Choosing the right serger depends on your sewing and crafting styles, preferences and experience. Because a serger sewing machine is such a large investment, it is important to understand which sewing serger can give you the stitches and design that you desire before you purchase one. Use our tips to choose a serger machine will all of the features you need.
How to Thread a Sewing Machine
Your new sewing machine is sure to become one of your prized possessions. With a sewing machine, you can create clothing, home decor items, gifts and crafts easily and affordably. One of the first things you will need to learn about sewing is how to thread your sewing machine. Threading a sewing machine is simple with a bit of practice. Be patient with yourself as you learn to thread your sewing machine and try not to get flustered if it doesn't come naturally right away. Eventually, threading your sewing machine will be like second nature.
How to Operate a Sewing Machine
Operating sewing machines can be a tricky process and requires a degree of patience in the beginning. Once you grasp the simple techniques that sewing requires, however, you will have the ability to sew almost anything you desire, using a sewing pattern or your own imagination and a sewing machine, saving you money and giving you a creative outlet. Learning how to sew is certainly worth the time investment.
How to Maintain a Sewing Machine
Sewing machines are big investments, meant to last through years of sewing and craft projects. If you want to keep your sewing machine in top condition, you need to do some maintenance on a regular basis. Maintaining your sewing machine can help you get the most out of it and enjoy sewing and quilting tasks for years or even decades. A well-maintained sewing machine will also reduce the need for repairs and tune-ups, saving you time and money.
Sewing Machine Buying Guide
Although there are many tools for sewing, the main tool is the sewing machine. Many sewing machines are available, with prices ranging from under $100 to several thousand, depending on features. Before choosing your new sewing machine, think about which of those features you would like to use. Be sure to choose one that can do everything you would like but won't overwhelm you with unnecessary buttons and knobs.
How to Choose a Sewing Machine
A sewing machine is a sound purchase that will provide you with the means to create a wide variety of useful and beautiful items. Home sewing is a rewarding hobby that saves time and money as well as fostering a sense of deep satisfaction at the end of a project. Sewing machines can also be passed down through generations, so your sewing machine purchase is a wise investment. With a sewing pattern, some basic sewing knowledge, and a few other supplies, you can turn fabric into useful items, crafts and lovely works of art. If you are ready to purchase a sewing machine, let us help you decide which one is going to be best for you.
How to Choose Sewing Machine Needles
Choosing needles for a sewing machine may seem like an easy task that takes very little forethought. In actuality, needles need to be chosen on a project-by-project basis, with the weight and texture of your fabric in mind. Some people prefer to stick with the universally sized needles that accompany their sewing machine, but for certain jobs, these needles will cause the tension to be off and stitches to start dropping. For these reasons, choosing sewing machine needles can be a complicated process. Use our tips to ensure that you are getting the correct sewing machine needles for your sewing project.
Best Brother Sewing Machines
If you like to sew or want to learn, Brother sewing machines will help you get the job done right. Whether you plan to sew simple curtains or your daughter's wedding dress, you need a reliable sewing machine, and a Brother sewing machine will allow you to create beautiful projects and clothing with ease. Known for their quality printers and electronic devices, Brother is a name synonymous with innovation, and a Brother sewing machine continues that tradition. Read on to discover the best sewing machines for the various projects you plan to create.
Sewing Machines Fact Sheet
With guidance and a touch of creativity, you can take on lots of different projects with sewing machines. From basic mechanical models to computerized sewing machines, these machines offer a variety of stitching options and allow you to create a professional finished product.
Sewing Machine Tips
Pick up an old hobby or learn how to sew with a new sewing machine. Whether you're a beginner or an experienced but out-of-touch sewer, buying a new sewing machine can spur you on to creative greatness and provide the motivation you need to complete your sewing goals. The only problem is choosing the best sewing machine for you. Because we at Overstock.com want to help you develop your talents and pick up new hobbies, we've put together this list of tips to help you buy and use your new sewing machine. Keep reading to learn more about how to find and start using a sewing machine.
Accessories for Singer Sewing Machines
Stock up on the best accessories for Singer sewing machines so you're always prepared for new projects or missing accessories. Most sewing machines come with a few basic accessories to get you started. Purchasing more sewing machine needles, bobbins and other sewing accessories that are compatible with your Singer sewing machines means you will always have a replacement when you need one. Keep reading to learn more about Singer sewing accessories for your sewing machine.
How to Troubleshoot Your Sewing Machine
Sewing machines may seem as though they are experiencing large problems when only small solutions are needed. Many sewing machines come with a few tools to do repairs, along with directions. Here are some small problems to check for before you look into costly repairs.
Features to Look for in an Overlock Sewing Machine
If you've ever dreamed of sewing your own clothing, you need an overlock sewing machine. Also called overlockers, these machines finish a seam or hem with various stitches that can connect piece fabrics like a book, create decorative edging and add strength to a garment while retaining flexibility. Choosing the best overlock sewing machine can be intimidating, though; all the major sewing machine manufacturers make overlockers, and they come with a huge variety of options. Keep reading to learn which features you should look for when shopping for overlock sewing machines.
How to Buy Quality Serger Sewing Machines
For clothes and other complicated sewing projects, serger sewing machines can be lifesavers. They cut edges, hem, finish seams and more, saving you lots of time and effort. The only problem is that there are so many sergers out there to choose from; sorting through all those options can be intimidating. Fortunately, this guide can walk you through the steps of considering which sewing machines to buy when you're ready to add one to your craft room. Keep reading for tips on buying quality serger sewing machines.
How to Choose Crafts and Sewing Storage
If you are an avid crafter, sewer or scrapbooker, you need crafts and sewing storage for all your supplies. Sewing and craft supplies have a tendency to spread themselves all over your craft room and become disorganized very quickly, so having the right storage and organization solutions in your craft and sewing space is essential. The problem is that there are as many options in the world of crafts and sewing storage as there are craft and sewing projects to try. To help you organize your space, store your supplies and retain your sanity, Overstock.com has created this guide to choosing crafts and sewing storage.
Types of Craft and Sewing Scissors
Whether you craft or sew, you know that having the right scissors for each task is essential. All-purpose scissors simply can't do all the cutting and snipping jobs you need to do for your scrapbook, embroidery project or quilt. Even having straight scissors for paper and rotary cutters for fabric won't quite do the trick. If you need a refresher course about the different craft scissors and sewing scissors out there, or if you're building your collection of craft supplies for the first time, keep reading to learn about the different types of craft and sewing scissors.
How To Sew a Handmade Pillow
Creating decor items for your home through sewing can be more satisfying than simply purchasing them, and making your own home accessories will let you create exactly the look you want. One of the simplest ways to add your own personal touch to your home decor is through the use of homemade pillows. Homemade pillows are simple to create and can completely change the look and style of your home for very little cost. All that is required is a sewing machine, a few sewing supplies and fundamental sewing skills.
How to Make a Doll Hat
Creating a doll hat can be a fun way to add style and flair to your doll collection. Doll hats are also adorable gifts for doll-lovers of any age. With just a bit of crafting experience and a sewing machine, you can create a variety of miniature hats for dolls of all sizes. Consider creating doll hats to match other doll clothing that you have sewn for complete doll outfits with style.
How to Make Your Own Pillowcases
If you're looking for a fun project and a way to add a personal touch to your bedroom decor, then you might consider making your own pillowcases. Sewing your own pillowcases will let you have the exact color and style you want. You can even embellish homemade pillowcases with decorative elements and make them truly unique. With just a few supplies and one of many easy-to-use sewing machines, you can start putting your personal stamp on every bed and pillow in the house. The process of making a pillowcase is simple as long as you follow a few rules.
How To Sew a Canvas Bag
Canvas bags have always been a popular choice for beach gear, baby supplies and casual purses, as they are well-liked for their durability. The recent upswing in environmental awareness has also made canvas totes a must-have replacement for traditional paper and plastic shopping bags. Canvas is strong and easily washed, and it is a natural, breathable fabric that lasts a long time. Commercial canvas bags are available in many styles, but you can sew your own canvas bags at home using a sewing machine and a few affordable supplies, saving money and having fun getting creative at the same time!
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10:20 am
Mon March 17, 2014
Second Minor Earthquake Shakes Harper County
The U.S. Geological Survey reports an earthquake shook southern Kansas near Anthony on Sunday.
The earthquake hit at 3:46 a.m. and measured 4.0 on the Richter scale.
Its epicenter was reported eight miles east-northeast of Anthony in Harper County.
It was at least the second earthquake in that area that week.
On Wednesday, an earthquake rated 3.4 on the Richter scale was recorded 14 miles east-northeast of Anthony.
Last month, Governor Brownback asked the director of the Kansas Geological Survey to lead a task force that will study whether human activity is causing an increase in minor earthquakes in Kansas.
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The training session will take place on Thursday, November 15, from 5:30 p.m. to 7:30 p.m. in Room 4085 at the UNC School of Law. This is the second training sessions for students interested in participating in the Cancer Pro Bono Legal Project, a collaboration between The Office of Public Interest and Pro Bono, the Duke Law Health Law Society, the Duke Cancer Institute, the UNC Law Health Law Society, and the UNC Cancer Institute. The project will provide legal assistance to cancer patients. In this training session, participants will receive training specifically on how to fill out necessary forms and help patients prepare Powers of Attorney and Advanced Directives. Feel free to bring a sandwich. Please RSVP to firstname.lastname@example.com and contact her for more information.
Cancer Pro Bono Legal Project Training: Part II
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TripAdvisor Reviews Evridiki Apartments Corfu
Travel Blogs from Corfu
Day 178
... front was pretty with a grassy area and palm trees on the beach side and a large wetlands area with lakes and lagoons on the inland side. The lake had lots of birds, we could see pelican, smew, small brown ducks ,heron, storks, american coots and what we think was cormorants swimming under the water, fishing, it's incredible how long they can stay under the water for, we followed them with the binoculars for ages and they never seemed to surface. When we returned to ...
Not much of an exploration
... Milan that we are paying for the ticket.
11/12 At sea
Yesterday I fell asleep at 3 and didn't wake until 7pm. Thus I was not surprised when I woke up at 1:15, thinking it must be 5am. I read a couple of chapters of my novel about a Venice policeman and fortunately fell asleep until 7am. For the first time in months there were no dark circles under my eyes this ...
Rome, Naples,Messina, Malta, Dubrovnik, Venice
... go so we took pictures of the other harbor and started back. We were accosted by a guy with a menu in English, pay in Kuna/Euro/Dollar, free aperitif, so we followed him up the stairs to the restaurant. We had exactly 200 Kuna (about 6/dollar) left and at first we tried to order so that we would use them up exactly. Then we forgot about that and just ordered. Our aperitif was vermouth (very different from American vermouth), Ed got spaghetti ...
... 8211; we had really good food the whole time - loved the dips, tzatziki, feta galore and salads especially. None of us however were brave enough to try the Corfu special – octopi.
The last day, Tuesday, our flight wasn't until 10pm that night so we just did much of the same. It wasn't as hot this day so we went for a nice big lunch as opposed to dinner and made the most of the last few hours. It looked like we were going to have a storm but the ...
Day 88 Corfu contiki day 6 (Parasailing, toga)
... then brought my laptop down to reception. I tried to use the WiFi, but it was not that good and i got no where.
After giving up and heading back up the hill – this time i counted upwards of 125 stairs, before
losing count. Back in my room i put my lap top in for charge and changed to swimmers again, then went back down the hill to the pool area. I swam, drank and relaxed. It was then almost dinner time, so i got out, went back up the hill to the room, changed ...


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Chapter 5. The Sensorimotor System
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by Bethany Brookshire In many scientific fields, the study of the body is the study of boys. In neuroscience, for example, studies in male rats, mice, monkeys and other mammals outnumber studies in females 5.5 to 1. When scientists are hunting for clues, treatments or cures for a human population that is around 50 percent female, this boys-only club may miss important questions about how the other half lives. So in an effort to reduce this sex bias in biomedical studies, National Institutes of Health director Francis Collins and Office of Research on Women's Health director Janine Clayton announced in May a new policy that will roll out practices promoting sex parity in research, beginning with a requirement that scientists state whether males, females or both were used in experiments, and moving on to mandate that both males and females are included in all future funded research. The end goal will be to make sure that NIH-funded scientists "balance male and female cells and animals in preclinical studies in all future [grant] applications" to the NIH. In 1993, the NIH Revitalization Act mandated the inclusion of women and minorities in clinical trials. This latest move extends that inclusion to cells and animals in preclinical research. Because NIH funds the work of morethan 300,000 researchers in the United States and other countries, many of whom work on preclinical and basic biomedical science, the new policy has broad implications for the biomedical research community. And while some scientists are pleased with the effort, others are worried that the mandate is ill-conceived and underfunded. In the end, whether it succeeds or fails comes down to interpretation and future implementation. © Society for Science & the Public 2000 - 2014
Keyword: Sexual Behavior; Pain & Touch
Link ID: 20247 - Posted: 10.27.2014
By BENEDICT CAREY A Polish man who was paralyzed from the chest down after a knife attack several years ago is now able to get around using a walker and has recovered some sensation in his legs after receiving a novel nerve-regeneration treatment, according to a new report that has generated both hope and controversy. The case, first reported widely by the BBC and other British news outlets, has stirred as much excitement on the Internet as it has extreme caution among many experts. "It is premature at best, and at worst inappropriate, to draw any conclusions from a single patient," said Dr. Mark H. Tuszynski, director of the translational neuroscience unit at the medical school of the University of California, San Diego. That patient — identified as Darek Fidyka, 40 — is the first to recover feeling and mobility after getting the novel therapy, which involves injections of cultured cells at the site of the injury and tissue grafts, the report said. The techniques have shown some promise in animal studies. But the medical team, led by Polish and English doctors, also emphasized that the results would "have to be confirmed in a larger group of patients sustaining similar types of spinal injury" before the treatment could be considered truly effective. The case report was published in the journal Cell Transplantation. The history of spinal injury treatment is studded with false hope and miracle recoveries that could never be replicated, experts said. In previous studies, scientists experimented with some of the same methods used on Mr. Fidyka, with disappointing results. © 2014 The New York Times Company
Keyword: Regeneration; Stem Cells
Link ID: 20230 - Posted: 10.22.2014
By Fergus Walsh Medical correspondent A paralysed man has been able to walk again after a pioneering therapy that involved transplanting cells from his nasal cavity into his spinal cord. Darek Fidyka, who was paralysed from the chest down in a knife attack in 2010, can now walk using a frame. The treatment, a world first, was carried out by surgeons in Poland in collaboration with scientists in London. Prof Wagih El Masri Consultant spinal injuries surgeon Details of the research are published in the journal Cell Transplantation. BBC One's Panorama programme had unique access to the project and spent a year charting the patient's rehabilitation. Darek Fidyka, 40, from Poland, was paralysed after being stabbed repeatedly in the back in the 2010 attack. He said walking again - with the support of a frame - was "an incredible feeling", adding: "When you can't feel almost half your body, you are helpless, but when it starts coming back it's like you were born again." He said what had been achieved was "more impressive than man walking on the moon". UK research team leader Prof Geoff Raisman: Paralysis treatment "has vast potential" The treatment used olfactory ensheathing cells (OECs) - specialist cells that form part of the sense of smell. OECs act as pathway cells that enable nerve fibres in the olfactory system to be continually renewed. In the first of two operations, surgeons removed one of the patient's olfactory bulbs and grew the cells in culture. Two weeks later they transplanted the OECs into the spinal cord, which had been cut through in the knife attack apart from a thin strip of scar tissue on the right. They had just a drop of material to work with - about 500,000 cells. About 100 micro-injections of OECs were made above and below the injury. BBC © 2014
Keyword: Regeneration; Stem Cells
Link ID: 20229 - Posted: 10.22.2014
BY Tina Hesman Saey SAN DIEGO — A Golden retriever that inherited a genetic defect that causes muscular dystrophy doesn't have the disease, giving scientists clues to new therapies for treating muscle-wasting diseases. The dog, Ringo, was bred to have a mutation that causes Duchenne muscular dystrophy in both animals and people. His weak littermates that inherited the same mutation could barely suckle at birth. But Ringo was healthy, with muscles that function normally. One of Ringo's sons also has the mutation but doesn't have the disease, said geneticist Natassia Vieira of Boston Children's Hospital and Harvard University October 19 at the annual meeting of the American Society of Human Genetics. The dogs without the disease had a second genetic variant that caused their muscles to make more of a protein called Jagged 1, Vieira and her colleagues discovered. That protein allows muscles to repair themselves. Making more of Jagged 1 appears to compensate for the wasting effect of the muscular dystrophy mutation, although the researchers don't yet know the exact mechanism. The finding suggests that researchers may one day be able to devise treatments for people with muscular dystrophies by boosting production of Jagged 1 or other muscle repair proteins. N. M. Vieira. The muscular dystrophies: Revealing the genetic and phenotypic variability. American Society of Human Genetics Annual Meeting, San Diego, October 19, 2014. © Society for Science & the Public 2000 - 2014
Keyword: Muscles; Movement Disorders
Link ID: 20226 - Posted: 10.22.2014
by Flora Graham This glowing blue web of neurons is usually what researchers examine when searching for a cure for Parkinson's. But a new study, part-funded by Parkinson's UK, hones in on the tiny yellow dots. These are the connections between brain cells known as synapses, has discovered a killer that targets these links, potentially paving the way for new treatments. Soledad Galli at University College London and her colleagues have found that the death of synapses in mice may be due to malfunctioning proteins called Wnt proteins. "If we confirm that Wnt is involved in the early stages of Parkinson's, this throws up exciting possibilities, not just for new treatment targets, but also for new ways to identify people with Parkinson's early on in their condition," says Galli. Most patients currently depend on the drug levodopa, which is over 50 years old and can have severe side-effects, in addition to becoming less effective over time. Moreover, it only masks the symptoms: there is no cure for Parkinson's and no way to stop its progression. Journal reference: Nature Communications, DOI: 10.1038/ncomms5992 © Copyright Reed Business Information Ltd
Keyword: Parkinsons; Apoptosis
Link ID: 20214 - Posted: 10.18.2014
|By Amy Yee Pouring a bucket of ice water over one's head may seem like a distant summer memory. But although the "ice bucket challenge" craze has died down, public awareness of amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, has never been stronger. The viral video campaign raised $115 million from more than 3 million donors for the ALS Association. In one month, from July 29 to August 29, donors raised $100.9 million, compared with $2.8 million during the same period the previous year. In early October, the ALS Association began spending that money. It approved $21.7 million of funding for six programs and initiatives by groups that include the academic-industry partnership ALS Accelerated Therapeutics, the New York Genome Center, three California labs that form the Neuro Collaborative, and Project MinE, which will map the genomes of 15,000 people with ALS (about 10 percent of ALS patients have a family member with the disease). The grants focus on developing gene therapies for common ALS genes and exploring approaches to counter two major contributors to the disease, the inflammation of nervous tissue and misfolded proteins in brain cells that control movement. These efforts may not only someday lead to new treatments, but may also point to the cause of ALS. At the level of basic research, scientists do not have a dominant theory from which to work, notes Tom Jessell, a neuroscientist and co-director of Columbia University's new Zuckerman Mind Brain Behavior Institute. Jessell is also the chair of the research advisory board of Project ALS, a nonprofit that identifies and funds ALS research. © 2014 Scientific American
Keyword: ALS-Lou Gehrig's Disease
Link ID: 20213 - Posted: 10.18.2014
By Carl T. Hall Even Clayton Kershaw, the Los Angeles Dodgers' pitching ace, makes mistakes now and then. And although very few of his mistakes seemed to do Giants hitters much good this season, a team of San Francisco scientists found a way to take full advantage. A new study by UCSF researchers revealed a tendency of the brain's motion-control system to run off track in a predictable way when we try to perform the same practiced movement over and over. The scientists found the phenomenon first in macaque monkeys, then documented exactly the same thing in Kershaw's game video. Although he struggled in a playoff appearance last week, the left-hander's pitching performance during the regular season was among the best on record. It included a minuscule 1.77 earned run average, a nearly flawless no-hitter in June, 239 strikeouts and only 31 walks. He led the major leagues with 10.85 strikeouts per nine innings pitched. In what turned out to be an early warm-up to the playoffs, UCSF scientists Kris Chaisanguanthum, Helen Shen and Philip Sabes delved into the motor-control system of the primate brain. Their study, published in the Journal of Neuroscience, could help design better prosthetic limbs — or make robots that move less like robots and more like Kershaw. Unlike most machines, our brains seem to never stop trying to adapt to new information, making subtle adjustments each time we repeat a particular movement no matter how practiced. This trial-by-trial form of learning has obvious advantages in a fast-changing world, but also seems prone to drift away from spot-on accuracy as those small adjustments go too far.
Keyword: Learning & Memory
Link ID: 20193 - Posted: 10.11.2014
by Andy Coghlan Ten years after the death of everyone's favourite Superman, Christopher Reeve, his son Matthew Reeve is pushing ahead with a spine-tingling clinical trial You're planning a large study of a paralysis treatment that has already helped four young men. What will it entail? This study will include 36 people with spinal cord injuries who will be treated with epidural stimulation – a technique in which a device is used to apply electrical current to the spinal cord. If we see the same results as we did in the first four, this therapy could have a profound impact on thousands of people living with paralysis. It has the potential to become as commonplace as the pacemaker is for cardiac patients. How well has the treatment worked for the four men who have already received it? Prior to epidural stimulation, they had all suffered chronic injuries caused by completely severed spinal cords. All four have seen dramatic improvements, including the ability to voluntarily move their toes, feet, ankles and legs, and even stand at times, when the device is on. One unexpected bonus has been the return of autonomic function, such as bladder and bowel control and sexual function. From a quality-of-life point of view, this is the biggest improvement. Also unexpectedly, these autonomic functions continue in all four men even when the device is switched off, although they still need it to stand, move their legs and do exercises. © Copyright Reed Business Information Ltd.
Keyword: Movement Disorders; Regeneration
Link ID: 20190 - Posted: 10.11.2014
Posted by Rachel Dolhun, MD, The ability to quit smoking, especially "cold turkey" or on the first attempt, has been heralded as a marker of strong willpower and determination. But could the ease with which one eschews cigarettes also serve as an early sign of Parkinson's disease (PD)? This is the conclusion drawn by Beate Ritz, MD, PhD, and colleagues from the University of California, Los Angeles in a recent study published in Neurology. Researchers compared lifelong tobacco use, use of nicotine substitutes, and individual's rating of their difficulty in trying to quit tobacco among 1,808 Danish people with PD and 1,876 control volunteers. They found that those with PD were less inclined to ever pick up the smoking habit, but, even if they did, they were less likely to need nicotine replacement therapies and able to more effortlessly stop smoking cigarettes. Therefore, ease of quitting smoking may be a sign of early PD. This joins a short list of other symptoms — smell loss, constipation and REM sleep behavior disorder — that usually predate diagnosis and are strongly associated with PD. Physicians rely heavily on such information to help confirm the diagnosis of Parkinson's, given that biomarkers, objective measurements of disease, are currently lacking. Research led by The Michael J. Fox Foundation is ongoing to identify biological markers of PD, which could help diagnose and treat people earlier. In the meantime, doctors must look for symptoms and behaviors to help identify Parkinson's. Researchers have long known that tobacco use was linked to a lower risk of PD. An ongoing Foundation-funded study is investigating whether nicotine might guard against or slow the progression of PD.
Keyword: Parkinsons; Drug Abuse
Link ID: 20189 - Posted: 10.11.2014
By Elizabeth Pennisi Four years ago, Igor Spetic lost his right arm in an industrial accident. Doctors outfitted him with a prosthetic arm that restored some function, but they couldn't restore his sense of touch. Without it, simple tasks like picking up a glass or shaking hands became hit-or-miss propositions. The lack of touch also robs Spetic of basic pleasures. "I would love to feel my wife's hand," he says. In time, he may regain that pleasure: Two independent research teams have now equipped artificial hands with sensors that send signals to the wearer's nerves to recreate this missing sense. The sensing technologies work only in the lab, but they have proved durable, and amputees who have tried them, including Spetic, say that they are effective. One technology advances the range of touch sensations available, while the other promises to enable touch through a better way to attach the prosthesis. "All of these results are very positive," says Mandayam Srinivasan, a neuroengineer at the Massachusetts Institute of Technology in Cambridge, who was not involved in either project. "Each of them fills a piece of the puzzle in terms of [prosthesis] development." Almost 40 years ago, researchers tried to provide sensory feedback by adding pressure sensors to prostheses that relayed the sensation through electrodes attached to nerves. But for the most part, they just made it seem like the hand was tingling. And durability has been an issue in such efforts, too. In February, Silvestro Micera, a neuroengineer at the Sant'Anna School of Advanced Studies in Pisa, Italy, and the Swiss Federal Institute of Technology in Lausanne and his team showed that it was possible for sensor-equipped prosthetic arms to gently or powerfully grab objects and even to distinguish a round from a square object. But the study lasted just 4 weeks, in part because of the delicate interface with the body. © 2014 American Association for the Advancement of Science.
Keyword: Pain & Touch; Robotics
Link ID: 20187 - Posted: 10.09.2014
by Colin Barras LOCKED in but not shut out: for the first time people who have lost the ability to move or talk because of a stroke may be able to communicate with their loved ones using a brain-computer interface. Brain injuries can leave people aware but almost completely paralysed, a condition called locked-in syndrome. Brain-computer interfaces (BCIs) can help some people communicate by passing signals from electrodes attuned to their brain activity as they watch a screen displaying letters. Subtle changes in neural activity let researchers know when a person wishes to select a particular on-screen item, allowing them to spell out messages by thought alone. Until now, BCIs have only been tested on healthy volunteers and people with amyotrophic lateral sclerosis, a neurodegenerative disease that leads to muscle wasting. But no one had tested whether the technology could help people locked in after a brain stem stroke. Now Eric Sellers and his colleagues at East Tennessee State University in Johnson City have tested the technique on a 68-year-old man. After more than a year of training he learned to communicate reliably via the BCI. He took the opportunity to thank his wife for her hard work, and to give his thoughts on gift purchases for his children (Science Translational Medicine, DOI: 10.1126/scitranslmed.3007801). © Copyright Reed Business Information Ltd.
Keyword: Stroke; Robotics
Link ID: 20185 - Posted: 10.09.2014
|By Tara Haelle The first step to treating or preventing a disease is often finding out what drives it. In the case of neurodegenerative disorders, the discovery two decades ago of what drives them changed the field: all of them—including Alzheimer's, Parkinson's, Huntington's and amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease)—involve the accumulation of misfolded proteins in brain cells. Typically when a protein misfolds, the cell destroys it, but as a person ages, this quality-control mechanism starts to fail and the rogue proteins build up. In Huntington's, for example, huntingtin protein—used for many cell functions—misfolds and accumulates. Symptoms such as muscular difficulties, irritability, declining memory, poor impulse control and cognitive deterioration accompany the buildup. Mounting evidence suggests that not only does the accumulation of misfolded proteins mark neurodegenerative disease but that the spread of the proteins from one cell to another causes the disease to progress. Researchers have seen misfolded proteins travel between cells in Alzheimer's and Parkinson's. A series of experiments reported in Nature Neuroscience in August suggests the same is true in Huntington's. In their tests, researchers in Switzerland showed that mutated huntingtin protein in diseased brain tissue could invade healthy brain tissue when the two were placed together. And when the team injected the mutated protein into a live mouse's brain, it spread through the neurons within a month—similar to the way prions spread, says Francesco Paolo Di Giorgio of the Novartis Institutes for BioMedical Research in Basel, who led the research. Prions are misfolded proteins that travel through the body and confer their disease-causing characteristics onto other proteins, as seen in mad cow disease. But it is not known if misfolded proteins involved in Huntington's convert other proteins as true prions do, according to Di Giorgio. © 2014 Scientific American
Keyword: Huntingtons
Link ID: 20181 - Posted: 10.08.2014
|By Tori Rodriguez Imagining your tennis serve or mentally running through an upcoming speech might help you perform better, studies have shown, but the reasons why have been unclear. A common theory is that mental imagery activates some of the same neural pathways involved in the actual experience, and a recent study in Psychological Science lends support to that idea. Scientists at the University of Oslo conducted five experiments investigating whether eye pupils adjust to imagined light as they do to real light, in an attempt to see whether mental imagery can trigger automatic neural processes such as pupil dilation. Using infrared eye-tracking technology, they measured the diameter of participants' pupils as they viewed shapes of varying brightness and as they imagined the shapes they viewed or visualized a sunny sky or a dark room. In response to imagined light, pupils constricted 87 percent as much as they did during actual viewing, on average; in response to imagined darkness, pupils dilated to 56 percent of their size during real perception. Two other experiments ruled out the possibility that participants were able to adjust their pupil size at will or that pupils were changing in response to mental effort, which can cause dilation. The finding helps to explain why imagined rehearsals can improve your game. The mental picture activates and strengthens the very neural circuits—even subconscious ones that control automated processes like pupil dilation—that you will need to recruit when it is time to perform. © 2014 Scientific American
Keyword: Learning & Memory
Link ID: 20176 - Posted: 10.08.2014
By Julie Rehmeyer Eight years ago, collapsed on a neurologist's examining table, I asked a naive question that turned out to be at the center of a long-running controversy: "So what is chronic fatigue syndrome?" I had just been diagnosed with the illness, which for six years had been gradually overtaking me. A week earlier, I had woken up barely able to walk. Fatigue hardly described what I felt. Paralysis was more like it. My legs seemed to have been amputated and replaced with tubes of liquid concrete, and just shifting them on the table made me grunt like an Olympic weightlifter. My bones hurt; my brain felt like a swollen mass. Speaking required tracking down and spearing each word individually as it scampered away from me. I felt as capable of writing an article about science — my job — as of killing a rhino with my teeth. "We don't understand it very well," my neurologist said, his face blank. He could recommend no tests, no treatments, no other doctors. I came to understand that, for him, the term chronic fatigue syndrome meant "I can't help you." My neurologist's understanding of the illness mirrored that of many doctors, who believe two things about CFS: that it's probably psychosomatic and that there's nothing doctors can do for it. One survey found that nearly half of doctors thought that CFS was or might be psychosomatic, and 58 percent said there wasn't enough information available to help them diagnose it. An examination of medical textbooks found that CFS was underrepresented, even compared with less-prevalent illnesses.
Keyword: Movement Disorders; Depression
Link ID: 20175 - Posted: 10.08.2014
By Gretchen Reynolds Encourage young boys and girls to run, jump, squeal, hop and chase after each other or after erratically kicked balls, and you substantially improve their ability to think, according to the most ambitious study ever conducted of physical activity and cognitive performance in children. The results underscore, yet again, the importance of physical activity for children's brain health and development, especially in terms of the particular thinking skills that most affect academic performance. The news that children think better if they move is hardly new. Recent studies have shown that children's scores on math and reading tests rise if they go for a walk beforehand, even if the children are overweight and unfit. Other studies have found correlations between children's aerobic fitness and their brain structure, with areas of the brain devoted to thinking and learning being generally larger among youngsters who are more fit. But these studies were short-term or associational, meaning that they could not tease out whether fitness had actually changed the children's' brains or if children with well-developed brains just liked exercise. So for the new study, which was published in September in Pediatrics, researchers at the University of Illinois at Urbana-Champaign approached school administrators at public elementary schools in the surrounding communities and asked if they could recruit the school's 8- and 9-year-old students for an after-school exercise program. This group was of particular interest to the researchers because previous studies had determined that at that age, children typically experience a leap in their brain's so-called executive functioning, which is the ability to impose order on your thinking. Executive functions help to control mental multitasking, maintain concentration, and inhibit inappropriate responses to mental stimuli. © 2014 The New York Times Company
Aaron E. Carroll For a drug to be approved by the Food and Drug Administration, it must prove itself better than a placebo, or fake drug. This is because of the "placebo effect," in which patients often improve just because they think they are being treated with something. If we can't compare a new drug with a placebo, we can't be sure that the benefit seen from it is anything more than wishful thinking. But when it comes to medical devices and surgery, the requirements aren't the same. Placebos aren't required. That is probably a mistake. At the turn of this century, arthroscopic surgery for osteoarthritis of the knee was common. Basically, surgeons would clean out the knee using arthroscopic devices. Another common procedure was lavage, in which a needle would inject saline into the knee to irrigate it. The thought was that these procedures would remove fragments of cartilage and calcium phosphate crystals that were causing inflammation. A number of studies had shown that people who had these procedures improved more than people who did not. However, a growing number of people were concerned that this was really no more than a placebo effect. And in 2002, a study was published that proved it. A total of 180 patients who had osteoarthritis of the knee were randomly assigned (with their consent) to one of three groups. The first had a standard arthroscopic procedure, and the second had lavage. The third, however, had sham surgery. They had an incision, and a procedure was faked so that they didn't know that they actually had nothing done. Then the incision was closed. The results were stunning. Those who had the actual procedures did no better than those who had the sham surgery. They all improved the same amount. The results were all in people's heads. © 2014 The New York Times Company
Keyword: Pain & Touch
Link ID: 20167 - Posted: 10.07.2014
By Lisa Sanders, M.D. On Thursday, we challenged Well readers to solve the mystery of a 62-year-old man with severe neck pain that spread down his arm, a facial droop, and numbness on his torso. Nearly 200 of you wrote in, and 20 of you correctly diagnosed the patient. The correct diagnosis is… Lyme disease. And more precisely, the early disseminated form of Lyme disease with neurological involvement The first person with the correct answer was Dr. Arielle Hay, a pediatric rheumatologist in Miami, who nailed it just half an hour after the case was posted. Dr. Hay said that the biggest clue was the UConn letterhead. When combined with the odd neurological symptoms, this reminder of where the case took place brought Lyme disease to mind. Lyme disease is one of those diseases that hardly needs an explanation. It was first described in 1977, in a case series of 51 children and parents who had mysterious episodes of joint pain and swelling. The children were initially diagnosed with juvenile rheumatoid arthritis, but the clustering of cases eventually led the investigators, Dr. Allen Steere and Dr. Stephen Malawista, to consider an infectious disease. The illness was named after the Connecticut town where most of the initial cases were located. The disease is caused by a spirochete, a spiral shaped bacterium carried by the Ixodes tick, and usually presents first with a distinctive, expanding red rash (called erythema migrans) that appears at the site of the bite in the early, localized stage of the disease. It is thought that the rash appears in up to 80 percent of Lyme infections. © 2014 The New York Times Company
Keyword: Pain & Touch; Movement Disorders
Link ID: 20166 - Posted: 10.07.2014
By Kevin Hartnett You may have seen that deliberately annoying "View of the World from Ninth Avenue" map featured on the cover of the New Yorker a while back. It shows the distorted way geography appears to a Manhattanite: 9th and 10th avenues are the center of the world, New Jersey appears, barely, and everywhere else is just a blip if it registers at all. As it turns out, a similar kind of map exists for the human body — with at least some basis in neuroscience. In August I wrote a story for Ideas on the rise of face transplants and spoke to Michael Sims, author of the book, "Adam's Navel: A Natural and Cultural History of the Human Form." During our conversation Sims mentioned an odd diagram published in 1951 by a neurosurgeon named Wilder Penfield. The diagram is known as "Homunculus" (a name taken from a weird and longstanding art form that depicts small human beings); it shows the human body scaled according to the amount of brain tissue dedicated to each part, and arranged according to the locations in the brain that control them. In the diagram, the eyes, lips, nose, and tongue appear grotesquely large, indicating that we devote an outsized amount of brain tissue to operating and receiving sensation from these parts of the body. (Sims's point was that we devote a lot of processing power to the face, and for that reason find it biologically disorienting that faces could be changeable.) The hand is quite large, too, while the toes, legs, trunks, shoulders, and arms are tiny, the equivalents of Kansas City and Russia on the New Yorker map. "Homunculus" seems like the kind of thing that would have long since been superseded by modern brain science, but it actually continues to have a surprising amount of authority, and often appears in neuroscience textbooks.
Keyword: Pain & Touch
Link ID: 20158 - Posted: 10.04.2014
James Hamblin Mental exercises to build (or rebuild) attention span have shown promise recently as adjuncts or alternatives to amphetamines in addressing symptoms common to Attention Deficit Hyperactivity Disorder (ADHD). Building cognitive control, to be better able to focus on just one thing, or single-task, might involve regular practice with a specialized video game that reinforces "top-down" cognitive modulation, as was the case in a popular paper in Nature last year. Cool but still notional. More insipid but also more clearly critical to addressing what's being called the ADHD epidemic is plain old physical activity. This morning the medical journal Pediatrics published research that found kids who took part in a regular physical activity program showed important enhancement of cognitive performance and brain function. The findings, according to University of Illinois professor Charles Hillman and colleagues, "demonstrate a causal effect of a physical program on executive control, and provide support for physical activity for improving childhood cognition and brain health." If it seems odd that this is something that still needs support, that's because it is odd, yes. Physical activity is clearly a high, high-yield investment for all kids, but especially those attentive or hyperactive. This brand of research is still published and written about as though it were a novel finding, in part because exercise programs for kids remain underfunded and underprioritized in many school curricula, even though exercise is clearly integral to maximizing the utility of time spent in class. The improvements in this case came in executive control, which consists of inhibition (resisting distraction, maintaining focus), working memory, and cognitive flexibility (switching between tasks). The images above show the brain activity in the group of kids who did the program as opposed to the group that didn't. It's the kind of difference that's so dramatic it's a little unsettling. The study only lasted nine months, but when you're only seven years old, nine months is a long time to be sitting in class with a blue head. © 2014 by The Atlantic Monthly Group.
Keyword: ADHD
Link ID: 20152 - Posted: 10.02.2014
By CATHERINE SAINT LOUIS Driven by a handful of reports of poliolike symptoms in children, federal health officials have asked the nation's physicians to report cases of children with limb weakness or paralysis along with specific spinal-cord abnormalities on a magnetic resonance imaging test. As a respiratory illness known as enterovirus 68 is sickening thousands of children from coast to coast, officials are trying to figure out if the weakness could be linked to the virus. The emergence of several cases of limb weakness among children in Colorado put doctors on alert in recent months. The Centers for Disease Control and Prevention issued an advisory on Friday, and this week, other cases of unexplained muscle weakness or paralysis came to light in Michigan, Missouri and Massachusetts. The C.D.C. is investigating the cases of 10 children hospitalized at Children's Hospital Colorado with unexplained arm or leg weakness since Aug. 9. Some of the children, who range in age from 1 to 18, also developed symptoms like facial drooping, double vision, or difficulty swallowing or talking. Four of them tested positive for enterovirus 68, also known as enterovirus D68, which has recently caused severe respiratory illness in children in 41 states and the District of Columbia. One tested positive for rhinovirus, which can cause the common cold. Two tested negative. Two patients' specimens are still being processed; another was never tested. It is unclear whether the muscle weakness is connected to the viral outbreak. "It's one possibility we are looking at, but certainly not the only possibility," said Mark Pallansch, director of the C.D.C.'s division of viral diseases. © 2014 The New York Times Company
Keyword: Movement Disorders
Link ID: 20150 - Posted: 10.02.2014


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Should a road course be added to the Chase? It's a mixed bag
SONOMA, Calif.— It's as predictable as a good Cabernet in the Sonoma Valley. Every time the NASCAR Sprint Cup Series comes to a road course, whether it's Sonoma Raceway or Watkins Glen International some 2,700 miles to the east, reporters pop ... FULL STORY »


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Capping off a record year that broke the $10 billion mark for the first time, audiences flooded the multiplexes over the Christmas holiday frame generating the largest weekend box office ever seen. Reigning champ Avatar led the way for a second consecutive time, but popular new releases Sherlock Holmes, Alvin and the Chipmunks: The Squeakquel, and It's Complicated
This weekend, a dozen years after scoring the biggest blockbuster of all-time, James Cameron returned to his comfortable spot at number one with his most expensive film to date, the sci-fi epic Avatar, which grossed more than every other film in the marketplace combined. On the other hand, Hugh Grant and Sarah Jessica Parker failed to charm audiences with their new date movie Did You Hear About the Morgans? which limped into fourth place with a weak opening. A massive blizzard rocked the east coast dumping up to two feet of snow in some areas causing movie theaters to see drastic cuts in attendance. Studios will now fight hard to capture lost business in the days ahead as most holdovers witnessed hefty declines.
Fairy tales came true as mothers and daughters powered the animated film The Princess and the Frog to the number one spot in its first weekend of nationwide release. But the frame's only other wide opener, Clint Eastwood's Nelson Mandela drama Invictus, suffered a soft debut in third place. Overall, the North American box office remained ahead of the same frame from a year ago as 2009 continued on its record pace towards shattering the $10 billion mark for the first time ever.
This weekend audiences across North America cheered on Sandra Bullock as she defeated all her opponents to clinch the number one spot at the box office with her runaway hit drama The Blind Side which spent the last two weeks in second place. Flip flopping positions, The Twilight Saga: New Moon finished in the runnerup spot while new releases were met with moderate to dismal results. It was typical for the frame as the weekend after the Thanksgiving holiday session always sees huge declines and unimpressive openings from new titles. But overall, the marketplace remained strong with sales up double digits over last year and 2007. Crowd favorite Sandra Bullock scored her second number one of the year with The Blind Side which climbed from second to first place with an estimated $20.4M for a relatively light 49% decline.
Audiences feasted on leftovers and drove the North American box office to a new record for the busy Thanksgiving holiday frame. Moviegoers were almost evenly split been vampire love and football heroics as The Twilight Saga: New Moon remained at number one while Sandra Bullock's The Blind Side held steady in second place with just $2.4M separating the two. That was a far cry from the $108.7M gap between the pair last weekend when they both opened as Twilight tumbled and Blind Side rose this weekend. The disaster film 2012 placed third as no new release managed to make it into the top three. The Top 20 over Thanksgiving weekend has consistently delivered $150-160M over the last six years but this time it soared to $181M, a new industry high.
Multiplex cash registers were overflowing as the hotly-anticipated vampire sequel The Twilight Saga: New Moon opened to gargantuan numbers generating the third largest opening in box office history and led the overall marketplace to the second biggest weekend tally of all-time. Debuting far back in second, but also surging past industry expectations, was Sandra Bullock's new football pic The Blind Side which got off to a fantastic start. The two new female-driven films attracted over $175M in combined ticket sales leading the top ten to soar to a jaw-dropping $245M.
This weekend Audiences were warned - by Mayans and film critics alike - but moviegoers around the world still flooded the multiplexes to see Roland Emmerich's latest disaster epic 2012 which generated an explosive global debut. Last weekend's top film A Christmas Carol held up well in its second weekend taking the runner-up spot while the awards hopeful Precious expanded moderately but raced all the way up to number four despite playing in fewer than 200 theaters. Overall ticket sales were slightly behind last year's levels, but well ahead of 2007. Blasting past expectations, Sony scored its best opening of 2009 with 2012 which grossed an estimated $65M this weekend from North America alone.
This weekend Moviegoers powered Jim Carrey's holiday kidpic A Christmas Carol to a number one opening but some fans remained stingy preventing the Disney 3D toon from meeting industry expectations. On the complete other side of the movie spectrum, the inner city drama Precious debuted to spectacular results enjoying one of the most impressive limited release debuts ever. Three other new wide releases were sprinkled across the top ten with mixed results as the overall marketplace fell behind year-ago levels. The 3D yuletide pic A Christmas Carol bowed on top this weekend grossing an estimated $31M from 3,683 locations and performed better than previous motion capture pics from director Robert Zemeckis, but worse than most animated films that kick off the holiday movie season in early November.
Four months after his death, Michael Jackson was the king of the box office as his concert documentary This Is It thrilled fans opening at number one. But with no other new films opening in wide release, and with Halloween dampening ticket sales on Saturday, the Top 20 slumped to its lowest point of 2009 with just $83M. Sony scored its seventh top spot debut of the year with This Is It, a look at preparations the music superstar was making for his sold-out London concerts, which grossed an estimated $21.3M over the weekend and $32.5M over five days since its Wednesday launch. Worldwide, the Kenny Ortega-directed pic grossed an estimated $101M with 68% of the total coming from overseas markets where Jackson's popularity has remained stronger over the years despite his many legal troubles. Domestically, This Is It averaged a solid $6,119 from 3,481 theaters over the Friday-to-Sunday span. The studio has reported that the Jackson pic has broken the all-time record for top-grossing concert film worldwide beating the $71.3M of last year's Hannah Montana/Miley Cyrus 3D concert flick. But that's not much of an achievement since very few concert films get wide releases in the first place and even fewer are given massive global launches like This Is It which unspooled on over 15,000 screens worldwide simultaneously. Montana bowed in North America on a Friday in just 683 3D locations (albeit with higher $15 tickets) and grossed $31.1M for a scorching $45,561 average on its way to a $65.3M domestic final representing a whopping 92% of its final global take. Its international release was much more limited.
This weekend what looked to be a close race between two major horror films ended up being no contest at all as moviegoers demanding a scare on the final full weekend before Halloween rallied behind the indie sensation Paranormal Activity which rose to number one in its fifth frame brutally punishing the opening for Saw VI which suffered the worst debut ever in the profitable franchise's history. Three other new releases ended up with small chunks of change outside of the top five while the overall marketplace slumped below last year's performance.
Three new releases hit the multiplexes while one indie sensation expands nationally hoping to strike gold and shake up the establishment. Leading the charge is the family film Where the Wild Things Are which gets the widest release by far and stands the best chance of capturing the number one spot. Also debuting is the horror film The Stepfather and the action drama Law Abiding Citizen. Meanwhile, the micro-budgeted thriller Paranormal Activity will capitalize on its enormous buzz by widening into all major markets on Friday making a serious play for the number two spot this weekend. Moviegoers poured into multiplexes to see a wide range of appealing films powering the box office to the biggest October weekend in history. Leading the way was the new adventure pic Where the Wild Things Are which bowed at number one followed by an exceptionally strong debut for the action entry Law Abiding Citizen in second. The most impressive performance came in third with the national expansion of the indie thriller Paranormal Activity which delivered the best average of any film. The four new wide releases kicked in a stunning $86M powering the Top 20 to $135M, a new record high for the month.
Couples ruled the box office as Universal's Couples Retreat took top honors at the box office this weekend. But the real story was the low-budget horror entry from Paramount, Paranormal Activity, which crashed the top five from only 159 theaters. Vince Vaughn, Jon Favreau, Kristen Bell and the rest of the ensemble cast of Couples Retreat landed, as expected, in the number one spot at the North American box office this weekend. The tale of four couples going through intense comical therapy grossed an estimated $35.3M this weekend from 3,000 theaters for a per screen average of $11,780. If that number holds, it would be the sixth highest opening weekend for the month of October, just ahead of a quadrilogy of Saw films. Poor reviews didn't hurt the film as its well-known cast certainly provided enough star power to make it the top choice for audiences.
This weekend Sony ruled the North American box office with an unlikely pair of hit comedies that led the way over a crowded frame that saw five films, each offering its share of laughs, shove their way into wide release. The violent horror-comedy Zombieland enjoyed a strong debut in first place bumping the studio's animated 3D pic Cloudy With a Chance of Meatballs into second after two weeks on top. But some other studios collected a bit of cash too. Disney's double feature Toy Story & Toy Story 2 (3D) drew impressive numbers in third while Warner Bros. saw lackluster results for its Ricky Gervais comedy The Invention of Lying in fourth.
Turning into the sleeper hit of the fall, Sony's blockbuster 3D toon Cloudy With a Chance of Meatballs easily ruled the North American box office posting the second smallest sophomore decline of any number one opener this year. Moviegoers were once again unimpressed with the new films that Hollywood studios tried to push on them with the Bruce Willis sci-fi pic Surrogates leading the pack with a sluggish debut in second place. The dance remake Fame bowed in third to mild numbers while the umpteenth horror film in recent weeks Pandorum failed to scare up much business. Sliding by an incredibly low 19%, Cloudy With a Chance of Meatballs showed remarkable strength in first place grossing an estimated $24.6M in its second weekend in theaters. Sensational word-of-mouth and a lack of competing family films or comedies helped the Sony release boost its ten-day tally to a solid $60M. The only number one opener in 2009 to enjoy a better second weekend hold was Liam Neeson's Taken which slipped by a mere 17% in early February. The revenge thriller banked $53.6M in its first ten days before continuing its leggy run which extended to an astonishing $145M final.
Moviegoers chose 3D fun over Hollywood stars as the animated comedy Cloudy With a Chance of Meatballs powered ahead of expectations to debut at number one grossing more than the three new live-action films combined. Matt Damon and Jennifer Aniston generated unimpressive numbers for their debuting films The Informant! and Love Happens, respectively, while Megan Fox failed to lure in ticket buyers to her horror entry Jennifer's Body. Overall, the North American box office did see a healthy double-digit gain over last year.
This weekend Tyler Perry ruled the charts once again as fans flocked to North American multiplexes for his latest film I Can Do Bad All By Myself which gave the filmmaker his fifth number one hit of the last five years - the most for any director. Opening to solid results in second place was the animated sci-fi actioner 9. But after a string of violent R-rated films in recent weeks, audiences stayed away from two competing thrillers which foolishly opened on the same day - the college slasher pic Sorority Row and the Antarctica-set murder mystery Whiteout. Both flops debuted outside the top five with averages of under $2,000. Overall, the box office dipped from a year ago with the Top 20 sliding 7% from the same weekend in 2008.
While the summer movie season started with a bang with the sharp claws of a mutant super hero, it ended quietly over the four-day Labor Day holiday session with the 3D horror sequel The Final Destination topping the lowest-grossing weekend of 2009. None of the three new releases managed to unseat last weekend's box office winner and the Top 20 sunk to just $116M over four days and $91M over three days -- the worst such tally of the year. With moviegoers not showing much excitement for the weekend's new releases, The Final Destination remained at number one by default grossing an estimated $15.4M in its second round over the four-day holiday session.
Another August weekend, another new R-rated movie overperforms at number one. This time it was the 3D fright flick The Final Destination which easily won the showdown between new horror sequels soaring ahead of expectations while Halloween II debuted in third grossing about what was expected from it. Holdovers and former chart-toppers Inglourious Basterds and District 9 both held up well making it that rare frame when violent R-rated films claimed the top four spots at the box office. The on-screen carnage drove ticket sales to an all-time high for the weekend before the Labor Day holiday session closing off an exceptionally powerful August box office.
This weekend Quentin, Brad, and Harvey lit up their stogies following the exceptional opening of their new World War II film Inglourious Basterds which topped the charts and exceeded all industry expectations to lead a robust late-summer session at the box office. The frame's three other new releases (Shorts, X-Games 3D: The Movie, and Post Grad, the highest of which grossed only $6.6 million) got the cold shoulder from moviegoers but the overall top ten surged ahead of last year and 2007 by more than 25%. Holdovers contributed too as no film in the top ten declined by more than 50%.
THIS WEEKEND Audiences went alien crazy as the sci-fi action drama District 9 rode a wave of strong buzz, slick marketing, and stellar reviews to debut easily at number one powering ahead of expectations. The counter-programming romance The Time Traveler's Wife fared well in its opening weekend while the frame's three other new releases struggled to find paying customers with the summer movie season slowly winding down. But the top ten saw encouraging double-digit gains over last year and 2007 as the marketplace continued to attract a sizable amount of business. Time will tell if this trend will continue and help the summer movie season to finish strong, with a handful of big releases yet to come.


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Welcome to Trion, a city rich in history, located in northwest Georgia. Trion is located in Chattooga County and is named after a factory in the town. Three Walker County businessmen, Andrew P. Allgood, Spencer S. Marsh and Col. W.K. Briers, officially organized the Trion factory on October 12, 1845. It has had few shut-downs since its first production in 1847. Three families owned and operated the mill through its first 150 years. The Allgood Family (1845-1912), the B.D. Riegel Family (1912-1987) and the R.B. Pamplin Family purchased the mill in 1987.
April's workshop/council meeting will be Thursday, April 23, 2015 at 6:00 pm.
The Town of Trion will be conducting surveys that are required as a part of an application for a Community Development Block Grant. Employees of the Town of Trion along with volunteers from the community will be conducting door to door surveys beginning on Friday afternoon, January 16, 2015. We appreciate your cooperation in completing these surveys. The purpose of the grant is to improve the water system in the Town of Trion. If you have any questions, please contact the maintenance supervisor, Eddy Willingham at 706-936-2384.
* We are an E-Verify Employer.
E-verify # 185932. Date of authorization January 30th, 2009
Town of Trion
1220 Pine St / P.O. Box 850
Trion, GA 30753
Tel: 706-734-2332
Fax: 706-734-7727