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Friday, February 27, 2015
The Blunt Facts About Blunts
Mixing tobacco with marijuana.
People who smoke a combination of tobacco and marijuana, a common practice overseas for years, and increasingly popular here in the form of "blunts," may be reacting to some unidentified mechanism that links the two drugs. Researchers believe such smokers would be well advised to consider giving up both drugs at once, rather than one at a time, according to an upcoming study in the journal Addiction.
Clinical trials of adults with cannabis use disorders suggest that "approximately 50% are current tobacco smokers," according to the report, which was published in the journal Addiction, and authored by Arpana Agrawal and Michael T. Lynskey of Washington University School of Medicine, with Alan J. Budney of the University of Arkansas for Medical Sciences. "As many cannabis users smoke a mixture of cannabis and tobacco or chase cannabis use with tobacco, and as conditioned cues associated with smoking both substances may trigger use of either substance," the researchers conclude, "a simultaneous cessation approach with cannabis and tobacco may be most beneficial."
A blunt is simply a marijuana cigar, with the wrapping paper made of tobacco and the majority of loose tobacco removed and replaced with marijuana. In Europe, smokers commonly mix the two substances together and roll the combination into a single joint, the precise ratio of cannabis and nicotine varying with the desires of the user. "There is accumulating evidence that some mechanisms linking cannabis and tobacco use are distinct from those contributing to co-occurring use of drugs in general," the investigators say. Or, as psychiatry postdoc Erica Peters of Yale put it in a press release, "There's something about tobacco use that seems to worsen marijuana use in some way." The researchers believe that this "something" involved may be a genetic predisposition. In addition to an overall genetic proclivity for addiction, do dual smokers inherit a specific propensity for smoked substances? We don't know—but evidence is weak and contradictory so far.
Wouldn't it be easier to quit just one drug, using the other as a crutch? The researchers don't think so, and here's why: In the few studies available, for every dually addicted participant who reported greater aggression, anger, and irritability with simultaneous cessation, "comparable numbers of participants rated withdrawal associated with dual abstinence as less severe than withdrawal from either drug alone." So, for dual abusers, some of them may have better luck if they quit marijuana and cigarettes at the same time. The authors suggest that "absence of smoking cues when abstaining from both substances may reduce withdrawal severity in some individuals." In other words, revisiting the route of administration, a.k.a. smoking, may trigger cravings for the drug you're trying to quit. This form of "respiratory adaption" may work in other ways. For instance, the authors note that, "in addition to flavorants, cigarettes typically contain compounds (e.g. salicylates) that have anti-inflammatory and anesthetic effects which may facilitate cannabis inhalation."
Studies of teens diagnosed with cannabis use disorder have shown that continued tobacco used is associated with a poor cannabis abstention rate. But there are fewer studies suggesting the reverse—that cigarette smokers fair poorly in quitting if they persist in cannabis use. No one really knows, and dual users will have to find out for themselves which categories seems to best suit them when it comes time to deal with quitting.
We will pass up the opportunity to examine the genetic research in detail. Suffice to say that while marijuana addiction probably has a genetic component like other addictions, genetic studies have not identified any gene variants as strong candidates thus far. The case is stronger for cigarettes, but to date no genetic mechanisms have been uncovered that definitively show a neurobiological pathway that directly connects the two addictions.
There are all sorts of environmental factors too, of course. Peer influences are often cited, but those influences often seem tautological: Drug-using teens are members of the drug-using teens group. Tobacco users report earlier opportunities to use cannabis, which might have an effect, if anybody knew how and why it happens.
Further complicating matters is the fact that withdrawal from nicotine and withdrawal from marijuana share a number of similarities. The researchers state that "similar withdrawal syndromes, with many symptoms in common, may have important treatment implications." As the authors sum it up, cannabis withdrawal consists of "anger, aggression or irritability, nervousness or anxiety, sleep difficulties, decreased appetite or weight loss, psychomotor agitation or restlessness, depressed mood, and less commonly, physical symptoms such as stomach pain and shakes/tremors." Others complain of night sweats and temperature sensitivity.
And the symptoms of nicotine withdrawal? In essence, the same. The difference, say the authors, is that cannabis withdrawal tends to produce more irritability and decreased appetite, while tobacco withdrawal brings on an appetite increase and more immediate, sustained craving. Otherwise, the similarities far outnumber the differences.
None of this, however, has been reflected in the structure of treatment programs: "Emerging evidence suggests that dual abstinence may predict better cessation outcomes, yet empirically researched treatments tailored for co-occurring use are lacking."
The truth is, we don't really know for certain why many smokers prefer to consume tobacco and marijuana in combination. But we do know several reasons why it's not a good idea. Many of the health-related harms are similar, and presumably cumulative: chronic bronchitis, wheezing, morning sputum, coughing—smokers know the drill. Another study cited by the authors found that dual smokers reported smoking as many cigarettes as those who only smoked tobacco. All of this can lead to "considerable elevation in odds of respiratory distress indicators and reduced lung functioning in those who used both." However, there is no strong link at present between marijuana smoking and lung cancer.
Some researchers believe that receptor cross-talk allows cannabis to modify receptors for nicotine, or vice versa. Genes involved in drug metabolism might somehow predispose a subset of addicts to prefer smoking. But at present, there are no solid genetic or environmental influences consistent enough to account for a specific linkage between marijuana addiction and nicotine addiction, or a specific genetic proclivity for smoking as a means of drug administration.
Agrawal, A., Budney, A., & Lynskey, M. (2012). The Co-occurring Use and Misuse of Cannabis and Tobacco: A Review. Addiction DOI: 10.1111/j.1360-0443.2012.03837.x
Photo credit: http://www.hightimes.com/
(First published at Addiction Inbox on March 22, 2012).
Posted by Dirk Hanson at 1:15 PM 1 comments Links to this post
Labels: blunts, cigarettes, marijuana, marijuana addiction, stop smoking
Monday, February 16, 2015
Troubling Link Between Shoplifting and Suicide
Compulsive theft can lead to tragic results.
In the fall of 2011, 71-year old Julia Grodinsky of London was convicted of shoplifting ornamental crystals and sentenced to 18 months of probation. What made the case unusual was that Grodinsky had been convicted of shoplifting 63 times over the past 60 years. It seems likely that the elderly thief will continue to steal, given her history of poor decision-making.
In The Republic, Plato asked whether thieves are made or born. It's an excellent question. Kleptomania, as it is traditionally called, is a special class of theft behavior: a chronic condition marked by compulsive stealing, often committed by people who could easily afford to buy what they steal. Brian L. Odlaug, a visiting researcher with the faculty of health and medical sciences at the University of Copenhagen, believes that kleptomania's primary feature is that it strikes "people who had a good marriage, nice home, great job—and yet could not stop from stealing inconsequential items." It is a rare disorder, he notes, "while sociopathy and theft for gain are quite common."
Curiously, the stealing never seems to be about money: The most recent study measuring income and shoplifting shows that people in the United States with incomes over $70,000 shoplift 30 percent more than those earning less than $20,000 a year. Today, compulsive shoplifting is labeled in the DSM-IV as an impulse control disorder. But historically this controversial diagnosis was variously seen as a biological disorder brought on by female agitation in department stores, an expression of repressed Freudian sexual desire, or a socially constructed disease that blossomed as a reaction to modernity. (A modest majority of shoplifters are women). Some observers in the early 20th Century even described kleptomania as a clever trick by psychiatrists to worm their way into law courts as purveyors of expert testimony.
Researchers today are more likely to be interested in what researcher Jon E. Grant, professor of psychiatry and behavioral neuroscience at the University of Chicago's Pritzker School of Medicine, calls the "neurocognitive sequelae of shoplifting." Grant and Orlaug are part of a group of psychiatric researchers who have been studying compulsive shoplifting for more than a decade. In the Archives of Suicide Research, lead author Odlaug documented abnormally high suicide rates among a group of 107 participants with kleptomania, 24.3 percent of whom had reported at least one suicide attempt. That figure is "6 to 24 times higher than in the United States general population," according to the report—roughly similar to the rate of suicide attempts among patients with schizophrenic disorders. It is higher than the rate of suicide attempts reported in cases of major depressive disorder (16.5 percent).
93 percent of the participants reported that their suicide attempt "was directly or indirectly due to their kleptomania symptoms (e.g., shame over the behavior; legal or personal problems resulting from shoplifting)." Believed to be the first attempt to survey the association between suicide and shoplifting, the study also teased out a strong association between bipolar spectrum disorder and kleptomania symptoms. The odds of a past suicide attempt were five times greater for kleptomania subjects who had also been diagnosed with bipolar disorder.
"The suicide data are very troubling," says Grant. "No one screens for this behavior, or when they are told about, most clinicians are very dismissive of it. There is definitely an attitude about kleptomania that it is more of a criminal problem."
Dr. Howard Shaffer, an associate professor at Harvard Medical School and director of the division on addiction at The Cambridge Health Alliance, who was not involved in the research, says that the work "seems a reasonable heads-up for clinicians to consider the role of impulsivity and its impact on suicidal ideation and behavior; kleptomania is one kind of proxy for impulsivity."
Compulsive shoplifting is commonly associated with substance abuse, pathological gambling, personality disorders, and bipolar syndrome, while sometimes overlapping with other impulse control disorders. Does it share common neurobiological deficits with these conditions? In a report published in Comprehensive Psychiatry, Grant and co-workers recruited young adults with no history of substance abuse or recognized mental health disorders, and ran them through a barrage of psychological testing. For the investigators, the important question was whether compulsive stealing is associated with certain neuropsychological dysfunctions that make kleptomaniacs different from other people. As it turned out, people with kleptomania risked more points in a test called the Cambridge Gambling Task, with results "similar to previous reports in people with damage to the ventromedial prefrontal cortices." It was an admittedly small study, but the researchers think the results show that shoplifting is not just a rash act, but one associated with "specific decision-making and working memory deficits."
A small neuromaging study published by Grant in 2006 showed evidence of "compromised white matter microstructure in inferior frontal areas," suggesting to Grant that the frontal parts of the brain involved in decision making "may not be as healthy." For his part, Odlaug thinks this finding may help explain "why so many patients report an 'irresistible' impulse to steal and a failure to inhibit that impulse." Odlaug cautions that while deficits of executive functioning appear to be involved, "I think it is far too early to suggest cognitive predictors of kleptomania or other disorders characterized by impulse control deficits."
Neuroscientist Marc Lewis, professor of human development and applied psychology at Radboud University in Nijmegen, The Netherlands, and author of Memoirs of an Addicted Brain, also questions whether sufficient data existed for asserting a link between impulsive behavior and working memory deficits. However, Lewis agrees that kleptomania "is seemingly its own disorder," and "overlaps only partially with other psychiatric categories."
Can kleptomania be cured, or treated successfully? In 2009, in an article for Biological Psychiatry, Grant and colleagues recorded the results of their work with 25 patients with kleptomania who were given high doses of naltrexone, a drug that blocks opioid receptors and is used to treat alcoholism and heroin addiction. All of the participants had been arrested, and had spent at least one hour per week stealing. The 8-week study, believed to be the first placebo-controlled trial of a drug for the treatment of shoplifting, resulted in a remission of symptoms in two-thirds of those on naltrexone. Says Odlaug: "With such a dearth of treatment data available, naltrexone appears to be the first-line treatment at this time. We have found that naltrexone at slightly higher doses is beneficial for a number of folks with kleptomania." Some researchers are also investigating use of cognitive behavioral therapies.
"Kleptomania is thought of as a behavioral addiction within addiction circles," Odlaug adds, while conceding that not everyone agrees with the concept of addiction to behaviors rather than substances. The neuropsychological approach to uncontrollable shoplifting as by no means unanimous. Writing in Global Society, Thomas Lenz and Rachel MagShamhrain argue that kleptomania is an "invented disease," coinciding with the rise of the department store and strong beliefs in feminine "hysteria."
"I think the general view," says Grant, "is that criminal issues, or potential criminal issues, are not as biological as, say, depression. It then becomes a vicious cycle, as lack of research then continues to justify why people say it is not really biological or psychological."
Lamentably, the connection between bipolar syndrome and shoplifting did not become apparent until recently, because people with bipolar symptoms are routinely ruled out of clinical studies of impulse control disorders. "Screening for people with co-occurring bipolar affective disorder and kleptomania is extremely important," Odlaug stresses. "Especially in psychiatric settings where kleptomania and other impulse control disorders often go unrecognized by clinicians."
(By Dirk Hanson. Originally published February 11, 2013, by the Dana Foundation.)
Photo Credit: http://blog.homesecuritystore.com/
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Labels: compulsive shopping, kleptomania, naltrexone, shoplifting, suicide
Thursday, February 5, 2015
Update on Synthetic Drug Surprises
Spicier than ever.
Four drug deaths last month in Britain have been blamed on so-called "Superman" pills being sold as Ecstasy, but actually containing PMMA, a synthetic stimulant drug with some MDMA-like effects that has been implicated in a number of deaths and hospitalizations in Europe and the U.S. The "fake Ecstasy" was also under suspicion in the September deaths of six people in Florida and another three in Chicago. An additional six deaths in Ireland have also been linked to the drug. (See Drugs.ie for more details.)
PMMA, or paramethoxymethamphetamine, causes dangerous increases in body temperature and blood pressure, is toxic at lower doses than Ecstasy, and requires up to two hours in order to take effect.
In other words, very nearly the perfect overdose drug.
Whether you call them "emerging drugs of misuse," or "new psychoactive substances," these synthetic highs have not gone away, and aren't likely to. As Italian researchers have noted, "The web plays a major role in shaping this unregulated market, with users being attracted by these substances due to both their intense psychoactive effects and likely lack of detection in routine drug screenings." Even more troubling is the fact that many of the novel compounds turning up as recreational drugs have been abandoned by legitimate chemists because of toxicity or addiction issues.
The Spice products—synthetic cannabinoids—are still the most common of the novel synthetic drugs. Hundreds of variants are now on the market. Science magazine recently reported on a UK study in which researchers discovered more than a dozen previously unknown psychoactive substances by conducting urine samples on portable toilets in Greater London. Call the mixture Spice, K2, Incense, Yucatan Fire, Black Mamba, or any other catchy, edgy name, and chances are, some kids will take it, both for the reported kick, and for the undetectability. According to NIDA, one out of nine U.S. 12th graders had used a synthetic cannabinoid product during the prior year.
"Laws just push forward the list of compounds," Dr. Duccio Papanti, a psychiatrist at the University of Trieste who studies the new drugs, said in an interview for this article. "The market is very chaotic, bulk purchasing of pure compounds are cheaply available from China, India, Hong-Kong, but small labs are rising in Western Countries, too. Some authors point out that newer compounds are more related to harms (intoxications and deaths) than the older ones. You can clearly see from formulas that newer compounds are different from the first ones: new constituents are added, and there are structural changes, so although we have some clues about the metabolism of older, better studied compounds, we don't know anything about the newer (and currently used) ones."
The problems with synthetic cannabinoids often begin with headaches, vomiting, and hallucinations. At the Department of Medical, Surgical, and Health Sciences at the University of Trieste, researchers Samuele Naviglio, Duccio Papanti, Valentina Moressa, and Alessandro Ventura characterized the typical ER patient on synthetic cannabinoids, in a BMJ article: "On arrival at the emergency department he was conscious but drowsy and slow in answering simple questions. He reported frontal headache (8/10 on a visual analogue scale) and photophobia, and he was unable to stand unassisted. He was afebrile, his heart rate was 170 beats/min, and his blood pressure was 132/80 mm Hg."
According to the BMJ paper, the most commonly reported adverse symptoms include: "Confusion, agitation, irritability, drowsiness, tachycardia, hypertension, diaphoresis [sweating], mydriasis [excessive pupil dilation], and hallucinations. Other neurological and psychiatric effects include seizures, suicidal ideation, aggressive behavior, and psychosis. Ischemic stroke has also been reported. Gastrointestinal toxicity may cause xerostomia [dry mouth], nausea, and vomiting. Severe cardiotoxic effects have been described, including myocardial infarction…"
In a recent article (PDF) for World Psychiatry, Papanti and a group of other associates revealed additional features of synthetic cannabimemetics (SC), as they are officially known: "For example, inhibition of γ-aminobutyric acid receptors may cause anxiety, agitation, and seizures, whereas the activation of serotonin receptors and the inhibition of monoamine oxidases may be responsible for hallucinations and the occurrence of serotonin syndrome-like signs and symptoms."
Papanti says researchers are also seeing more fluorinated drugs. "Fluorination is the incorporation of fluorine into a drug," he says, one effect of which is "modulating the metabolism and increasing the lipophilicity, and enhancing absorption into biological membranes, including the blood-brain barrier, so that a drug is available at higher concentrations. An increasing number of fluorinated synthetic cannabinoids are available, and fluorinated cathinones are available, too."
A primary problem is that physicians are still largely unacquainted with these chemicals, several years after their current popularity began. This is entirely understandable. In addition to the synthetic cathinones, several new mind-altering substances based on compounds discovered decades ago have also surfaced lately. Papanti provided a partial list of additional compounds that have led to official concern in the EU:
—Synthetic opioids (the best known are AH-7921, MT-45)
—Synthetic stimulants (the best known are MDPV, 4,4'-DMAR)
—New synthetic psychedelics (the NBOMe series)
—New dissociatives (Methoxetamine, Methoxphenidine, Diphenidine)
—New performance enhancing drugs (Melanotan, DNP)
—Gaba agonists (Phenibut, new benzodiazepines)
Most of the new and next-generation synthetics are not readily detected by standard drug screen processes. Spice drugs will not usually show up on anything but the most advanced test screening, using gas chromatography or liquid chromatography-tandem mass spectrometry—high tech tools which are rarely available for anything but serious (and costly) forensic investigations.
"Testing is a big problem," Papanti declares. "From a clinical point of view, do you need the test to make a diagnosis of intoxication, for following up an addiction treatment, or for forensic purposes? With the new drugs, maybe taken together, with different pharmacology, we are not very sure about this yet. If I want to have confirmation of a diagnosis of SC intoxication, I need two weeks as an average, in order to obtain the result. Your patient has been discharged by that time, or in the worse case, he is dead."
Another major problem, according to Papanti, "is that the machines need sample libraries in order to recognize the compound, and samples mean money. Plus, they need to be continuously updated."
In summary, there is no antidote to these drugs, but intoxication is general less than 24 hours, and the indicated medical management is primarily supportive. If you plan to take a drug marketed as Ecstasy, or indeed any of the spice or bath salt compounds, Drugs.ie notes that there are some basic rules of conduct that will help maximize the odds of a safe trip:
—If you don't "come up" as quickly as anticipated, don't assume you need another pill. PMMA can take two hours or more to take effect. Do not "double drop."
—If you don't feel like you expected to feel, and are noticing a "pins-and-needles" feeling or numbness in the limbs, consider the possibility that another drug is involved.
—Don't mix reputed Ecstasy with other drugs, especially alcohol, as PMMA reacts very dangerously with excessive alcohol.
—Remember to hydrate, but don't overhydrate. If you go dancing, figure on about a pint per hour.
Posted by Dirk Hanson at 11:23 AM 0 comments Links to this post
Wednesday, January 28, 2015
Smoking and Sadness
The chemistry of sorrow during nicotine withdrawal.
When you smoke a cigarette, nicotine pops into acetylcholine receptors in the brain, the adrenal glands, and the skeletal muscles, and you get a nicotine rush. Just like alcohol, a cigarette alters the transmission of several important chemical messengers in the brain. "These are not trivial responses," said Professor Ovide Pomerleau of the University of Michigan Medical School. "It's like lighting a match in a gasoline factory."
Experiments at NIDA's Addiction Research Center in Baltimore have confirmed that nicotine withdrawal not only makes people irritable, but also impairs intellectual performance. Logical reasoning and rapid decision-making both suffer during nicotine withdrawal. Acetylcholine appears to enhance memory, which may help explain a common lament voiced by many smokers during early withdrawal. As summarized by one ex-smoker, "I cannot think, cannot remember, cannot concentrate."
But there is another, less widely discussed aspect of nicotine withdrawal: profound sadness. Profound enough, in many cases, to be diagnosed as clinical unipolar depression.
Of course, people detoxing from addictive drugs like nicotine are rarely known to be happy campers. But quitting smoking, for all its other withdrawal effects, reliably evokes a sense of acute nostalgia, like saying goodbye to a lifelong friend. The very act of abstinence produces sadness, joylessness, dysphoria, melancholia—all emotional states associated with unipolar depression.
Work undertaken by Dr. Alexander Glassman and his associates at the New York State Psychiatric Institute has nailed down an unexpectedly strong relationship between prior depression and cigarette smoking, and the findings have been confirmed in other work. This sheds important light on the question of why some smokers repeatedly fail to stop smoking, regardless of the method or the motivation. The problem, as Glassman sees it, is "an associated vulnerability between affective [mood] disorders and nicotine."
A group of Canadian researchers, working out of the Centre of Addiction and Mental Health (CAMH), and the Department of Psychiatry at the University of Toronto, believe they have isolated the specific neuronal mechanisms responsible for the profound sadness of the abstinent smoker.
Writing in the Archives of General Psychiatry, the investigators, who had access to what the CAMH proudly calls the only PET scanner in the world dedicated to mental health and addiction research, gave PET scans to 24 healthy smokers and 24 healthy non-smokers. Non-smokers were scanned once, while heavy and moderate cigarette smokers were scanned after smoking a cigarette, and also after a period of acute withdrawal. Earlier research of this kind had focused on nicotine's effect on dopamine release. But Ingrid Bacher and her coworkers in Toronto were measuring MAO-A levels in the prefrontal and anterior cingulate regions, two areas known to be involved in "affect," or emotional responses. When patients suffering from major depressive disorders get scanned, they tend to show elevated levels of MAO-A. The so-called MAO-A inhibitors Marplan, Nardil, Emsam, and Parnate are still in use as antidepressant medications. In general, the higher the levels of MAO-A, the lower the levels of various neurotransmitters crucial to pleasure and reward. A high level of MAO-A would suggest that the enzyme was significantly altering the activity of serotonin, dopamine, and norepinephrine in brain regions involved in mood.
The researchers found that smokers in withdrawal had 25-35% more MAO-A binding activity than non-smoking controls. "This finding may explain why heavy smokers are at high risk for clinical depression," says Dr. Anthony Phillips, Scientific Director of the Canadian Institutes of Health Research's (CIHR's) Institute of Neurosciences, Mental Health and Addiction, which funded this study.
Although researchers involved in these kinds of drug studies almost always claim that the work is likely to lead to new pharmacological therapies, the plain truth is that such immediate spinouts are rare. But in this case, it does seem like the study provides a clear incentive to investigate the clinical standing of MAO-A inhibitors as an adjunct therapy in stop-smoking programs. "Understanding sadness during cigarette withdrawal is important because this sad mood makes it hard for people to quit, especially in the first few days," said Dr. Jeffrey Meyer, one of the study authors.
As one addiction researcher noted, an associated vulnerability to depression "isn't going to cover everybody's problem, and it doesn't mean that if you give up smoking, you're automatically going to plunge into a suicidal depression. However, for people who have some problems along those lines, giving up smoking definitely complicates their lives."
Bacher, I., Houle, S., Xu, X., Zawertailo, L., Soliman, A., Wilson, A., Selby, P., George, T., Sacher, J., Miler, L., Kish, S., Rusjan, P., & Meyer, J. (2011). Monoamine Oxidase A Binding in the Prefrontal and Anterior Cingulate Cortices During Acute Withdrawal From Heavy Cigarette Smoking Archives of General Psychiatry, 68 (8), 817-826 DOI: 10.1001/archgenpsychiatry.2011.82
(First published 8-4-11).
Posted by Dirk Hanson at 4:46 PM 0 comments Links to this post
Friday, January 23, 2015
The Losing Battle For Perpetual Reward
Or why you can't stay high forever.
The amphetamine high, like the cocaine high, is a marvel of biochemical efficiency. Stimulants work primarily by blocking the reuptake of dopamine molecules in the synaptic gap between nerve cells. Dopamine remains stalled in the gap, stimulating the receptors, resulting in higher dopamine concentrations and greater sensitivity to dopamine in general. Since dopamine is involved in moods and activities such as pleasure, alertness and movement, the primary results of using cocaine or speed—euphoria, a sense of well being, physical alertness, and increased energy—are easily understood. Even a layperson can tell when lab rats have been on a meth binge. The rapid movements, sniffing, and sudden rearing at minor stimuli are not that much different in principle from the outward signs of meth intoxication among higher primates.
Chemically, cocaine and amphetamine are very different compounds. Psychoactively, however, they are very much alike. Of all the addictive drugs, smoked cocaine and speed have the most direct and most devastatingly euphoric effect on the dopamine systems of the brain. Cocaine and amphetamine produce rapid classical conditioning in addicts, demonstrated by the intense cravings touched off by such stimuli as the sight of a building where the user used to buy or sell. Environmental impacts of this nature can produce marked blood flow increases to key limbic structures in abstinent addicts.
In clinical settings, cocaine users have a hard time distinguishing between equal doses of cocaine and Dexedrine, administered intravenously. As we know, it is the shape of the molecule that counts. The amphetamines are shaped like dopamine and norepinephrine, two of the three reward chemicals. Speed, then, is well suited to the task of artificially stimulating the limbic reward pathway. Molecules of amphetamine displace dopamine and norepinephrine in the storage vesicles, squeezing those two neurotransmitters into the synaptic gap and keeping them there. By mechanisms less well identified, cocaine accomplishes the same feat. Both drugs also interfere with the return of dopamine, norepinephrine, and serotonin molecules to their storage sacs, a procedure known as reuptake blocking. Cocaine works its effects primarily by blocking the reuptake of dopamine.
Amphetamine was once one of the most widely prescribed drugs in the pharmacological cornucopia. It exists in large part now as a recreational drug of choice, abuse, and addiction. The same is true of cocaine. It was replaced as a dental anesthetic long ago, in favor of non-addictive variants like Novocain. The same tragic list of statistical side effects that apply to abusers of alcohol, heroin and nicotine also apply to stimulant abusers: Increased risk of car accidents, homicides, heart attack, and strokes.
In the late 1990s, scientists at Johns Hopkins and NIDA showed that opiate receptors play a role in cocaine addiction as well. PET scans demonstrated that cocaine addicts showed increased binding activity at mu opiate receptors sites in the brain during active cocaine addiction. Take away the cocaine, and the brain must cope with too many empty dopamine and endorphin receptors. It is also easy to understand the typical symptoms of cocaine and amphetamine withdrawal: lethargy, depression, anger, and a heightened perception of pain. Both the cocaine high and the amphetamine high are easily augmented with cigarettes or heroin. These combinations result in "nucleus accumbens dopamine overflow," a state of neurochemical super saturation similar to the results obtained with the notorious "speedball"—heroin plus cocaine.
With the arrival of smokable forms of cocaine and amphetamine, the race to pin down the biology of stimulation became even more urgent. Stimulants in smokable form—crack and ice—are even more rapidly addictive for addiction-prone users. "The reason has to do with the hydraulics of the blood supply," a researcher at the University of Minnesota explained to me. "High concentrations are achieved with each inhalation, and sent right upstairs to the brain—but not all of the brain simultaneously. The target of the flow of blood is the limbic system, whereas the remainder of the brain is exposed to much milder concentrations."
This extraordinarily concentrated jolt to the reward center is the reason why smokable cocaine and speed are able to pack such a wallop. The entire range of stimulative effects hits the ventral tegmental area and associated reward regions of the brain in seconds, and the focused nature of the impact yields an astonishingly pleasurable high.
But the long-term result is exactly the opposite. It may sound dour and religious, but the scientific fact of the matter is that continuous chemical pleasure extracts its fee in the end: The body's natural stock of these neurotransmitters starts to fall as the brain, striving to compensate for the artificial flooding of the reward center, orders a general cutback in production. At the same time, the receptors for these neurotransmitters become excessively sensitive due to the frequent, often unremitting nature of the stimulation.
"It's clear that cocaine causes depletion of dopamine, norepinephrine, serotonin—it is a general neurotransmitter depleter," said my research source. "That may account for many of the effects we see after someone has stopped using cocaine. They're tired, they're lethargic, they sleep; they may be depressed, moody, and so on." Continued abuse of stimulant drugs only makes the problem worse. One reason why cocaine and amphetamine addicts will continue to use, even in the face of rapidly diminishing returns, is simply to avoid the crushing onset of withdrawal. Even though the drugs may no longer be working as well as they once did, the alternative—the psychological cost of withdrawal—is even worse. In the jargon used by Alcoholics Anonymous, addicts generally have to get worse before they can get better.
When addicts talk about "chasing a high," the metaphor can be extended to the losing battle of neurotransmitter levels.
[First published September 28, 2011]
Graphics Credit: http://www.keepcalm-o-matic.co.uk
Posted by Dirk Hanson at 11:26 AM 2 comments Links to this post
Wednesday, January 7, 2015
Rotting from the Inside
Smoking and the decline of the body.
We all know smoking is bad for your health. It causes lung cancer and emphysema and contributes to heart disease. But that's not the end of the list. Recently, Public Health England, a government organization, collected and analyzed research on the contribution smoking makes to other forms of internal body damage. Authored by Dr. Rachael Murray of the UK Centre for Tobacco and Alcohol Studies and the University of Nottingham, the study looked at the correlation between smoking and the musculoskeletal system, the cognitive system, dental health, and vision.
And the results of various meta-analyses are exactly as grim as we might expect. (You can download the PDF HERE.)
Bones, Muscle, and Tissue
Smoking does steady harm to the musculoskeletal system of habitual smokers. Osteoporosis in mature smokers may result from a loss of bone mineral density, a condition for which smoking "is a long established contributing risk factor." There are a number of ways smoking can affect bone mineral density, says the report, including "decreased calcium absorption, lower levels of vitamin D, changes in hormone levels, reduced body mass, increased free radicals and oxidative stress, higher likelihood of peripheral vascular disease and direct effects of toxic components of tobacco smoke on bone cells."
Moreover, smoking and broken bones go together like apple pie and ice cream, or in this case, bangers and mash. Overall in the UK, "current smokers have been reported to be at a 25% increased risk of any fracture," the report concludes. The author notes that the greatest risk for smokers are seen at the hip and the lumbar spine, and women smokers in particular "were at a 17% greater risk of hip fracture at age 60, 41% at 70, 71% at 80 and 108% at 90." The risk of fracture and the increased bone repair time decreases slowly in former smokers, and it may take 5 to 10 years before abstinent smokers see any statistical benefits.
Researchers have also documented a causal relationship between cigarette smoking and the onset of rheumatoid arthritis. But it is not known whether smoking cessation benefits existing patients with this condition.
As for soft tissue damage, a meta-analysis of 40 studies showed that smoking was associated with "a 33% increased prevalence of low back pain within the previous 12 months, 79% increased prevalence of chronic back pain and 114% increased prevalence of disabling lower back pain" among British smokers. Another study of 13,000 subjects showed that current and ex-smokers experienced up to 60% more pain in the lower back, upper neck and lower limbs than people who had never smoked. Smokers were also "74% more likely than non-smokers to have a rotator cuff tear," Dr. Murray writes.
The Brain in Your Head
Chronic cigarette smoking hastens the decline in cognitive function that occurs with age. And there is a disturbing link between tobacco smoking and dementia: "A meta-analysis of eight studies published in 2008 reported that current smokers were 59% more likely than never-smokers to suffer Alzheimer's disease and 35% more likely to suffer vascular dementia." Earlier studies showed even higher risk percentages. Here, there is the possibility that smoking succession could reduce dementia onset. Two meta-analyses included in the report showed no association between former smoking and risk of dementia.
General cognitive impairment in adults over 50 is "consistently associated" with smoking, according to the UK report. "Faster declines in verbal memory and lower visual search speeds have been reported in male and female smokers aged 43 and 53, with the effect largest in those who smoked more than 20 cigarettes per day, independent of other potentially confounding factors."
Dental Damage
Smoking is the primary cause of oral cancer, and the risk of developing it is three times less for non-smokers. Smoked and smokeless tobacco are linked to various non-malignant maladies of the soft and hard tissues in the oral cavity. Alcohol is a risk factor for oral cancer as well, "and is almost tripled in alcohol drinkers who smoke."
Peridontitis, the inflammatory condition marked by bleeding gums and degeneration leading to tooth loss (and an associated greater risk of coronary heart disease) is three to four times as common in adult smokers. And although there are other confounding socioeconomic influences, smoking is also a risk indicator for missing teeth in older smokers and previous smokers. The increased peridontitis risk lasts for several years after smoking cessation.
As for cavities and general tooth decay (caries), "Although the association between smoking and prevalence of dental caries can be attributed to poor dental care and oral hygiene, a cross-section study with a four-year follow-up found that daily smoking independently predicts caries development in smokers."
A Dim View
Neovascular and atrophic age-related macular degeneration, the eye conditions that cause a gradual loss of vision, are causally related to cigarette smoking. "A recent meta-analysis reported significant increases in macular degeneration of between 78% and 358%, depending on the study design." Smokers tend to develop the disease ten years earlier than non-smokers, and heavy smokers are at particular risk.
Finally, a number of cohort and case-control studies show a statistically significant link between smoking and cataracts, the cloudy patches over the eye that cause blurred vision. In current smokers, the increased risk is pegged at about 50%. "Smoking cessation reduces risks over time, however, the larger the exposure the longer it takes for the risk to reduce and this risk is unlikely to return to that of a never smoker."
Neovascular and atrophic age-related macular degeneration, the eye conditions that cause a gradual loss of vision, are causally related to cigarette smoking. "A recent meta-analysis reported significant increases in macular degeneration of between 78% and 358%, depending on the study design." Smokers tend to develop the disease ten years earlier than non-smokers, and heavy smokers are at particular risk.
Finally, a number of cohort and case-control studies show a statistically significant link between smoking and cataracts, the cloudy patches over the eye that cause blurred vision. In current smokers, the increased risk is pegged at about 50%. "Smoking cessation reduces risks over time, however, the larger the exposure the longer it takes for the risk to reduce and this risk is unlikely to return to that of a never smoker."
Photo credit: hhttp://www.healthcareaboveall.com/
Posted by Dirk Hanson at 7:00 PM 0 comments Links to this post
Saturday, January 3, 2015
The Greeks and the Romans on Alcohol
Wine and Beer in Antiquity
"When men drink, then they are rich and successful and win lawsuits and are happy and help their friends. Quickly, bring me a beaker of wine, so that I may wet my mind and say something clever."
"I like best the wine drunk at the cost of others."
"Persians are quite devoted to drinking wine…."
"We should not drink like the Carmani… These people, namely, eager to prove their friendship in their drinking bouts, open the veins of the forehead, and mixing the blood which streams down in their wine, they imbibe it, in the belief that to taste each other's blood is the highest proof of friendship."
"The wine urges me on, the bewitching wine, which sets even a wise man to singing and to laughing gently and rouses him up to dance and brings forth words which were better unspoken."
"This is the great evil in wine, it first seizes the feet; it is a cunning wrestler."
"Wine prepares the heart for love unless you take too much."
"Three bowls only do I mix for the temperate—one to health, which they empty first, the second to love and pleasure, the third to sleep. When this is drunk up wise guests go home. The fourth bowl is ours no longer, but belongs to violence; the fifth to uproar, the sixth to drunken reveal, the seventh to black eyes."
—Dionysus, by way of Eubulus
"The peoples of the Mediterranean began to emerge from barbarism when they learnt to cultivate the olive and the vine."
"…the Egyptians became fond of wine and bibulous; and so a way was found among them to help those who could not afford wine, namely, to drink that made from barley; they who took it were so elated that they sang, danced, and acted in every way like persons filled with wine."
Graphics Credit: http://www.opwine.com/
Posted by Dirk Hanson at 6:16 PM 1 comments Links to this post
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This was my first visit to Amsterdam and I went with the tripadvisor ratings in choosing this B&B for out two night stay. Actually, it was even better than expected. This small (two rooms) property is on a quiet street within easy walking distance to the major museums and a few blocks from the trolley. We arrived by train and immediately bought three day trolley passes which turned out to be a great idea, as we were able to travel about at will without additional expense. Upon arrival, Frank and Oki spent time with us, giving us a map and showing us the places of interest. They continued to be around when needed and were extremely helpful. The room was great. We had the room in the front, overlooking the street, but the location is so quiet that it wasn't a problem. The bed was comfortable and the room was spacious and included a flat screen tv and a nespresso machine. A lovely breakfast was served in the room each day. The bathroom was spotless and modern. We couldn't have been more pleased and will definitely stay here when we return to Amsterdam.
- Official Description (provided by the hotel):
- 'Le Quartier Sonang' is a peaceful, quiet townhouse in the most popular district of Amsterdam. The two comfortable guestrooms at the first floor in this 19th century original townhouse are located only five minutes away from the Leidseplein, Vondelpark, P.C. Hooftstraat, all famous museums and the concert building. And after a day in the city, you are going to have the most exciting experience in you life. You'll be sleeping on a cloud! We have the best beds in Europe. ... more less

subset: commoncrawl


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Find splendid Des Moines apartments for rent located along the shoreline of Puget Sound. Less than a 30 minute drive south of Seattle, Des Moines is also just 20 miles from Tacoma. Take advantage of the local city-operated marina where you can launch your boat or fish off the pier. Within Saltwater State Park you can take camping trips and head out into trails that are enshrouded in forest.
Apartments in Des Moines that are near Des Moines Overlook Park will have easy access to the beach. At the local park, there is a basketball court and fields for playing baseball and softball. The 5.2-acre Field House Park not only has a gorgeous view, but also a skatepark, tennis court and recreation area. You will find a walking path along with the fishing pier and boat launch at Redondo Pier.
The average cost of living in Des Moines is 15 percent more expensive than the average in Washington. With median rental rates that are just 1.7 percent greater than the Washington average, Des Moines apartments for rent are easy to come by with 46 percent of the vacant properties available.
If you are looking for low income housing in Des Moines, head to the King County Housing Authority for Section 8 Vouchers. The department is committed to providing affordable Des Moines apartments to local residents.
Some of the top employers of residents living in Des Moines apartments for rent include Highline School District, Highline Community College and the city itself. With the unemployment rate on a downward slope since November 2010, you will find many different career opportunities. In December 2012, that figure had dropped to 7.2 percent.
Are you looking to further your education while living in apartments for rent in Des Moines? You may want to consider attending Highline Community College on the south end of town. Not only is the college a top employer of the city, but it also provides residents with the necessary skills to start their own business!
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text:
I shall quietly abide on a calm sea
And when the waters violently strike and gash the boat
I shall simply calm myself and thee
. . . . . . . .
I shall sit atop a lone hill gazing down on the soft grass
And when the wind forms into gusts that whip my skin
I shall simply shift my thoughts to meditate on gratitudinal things
. . . . . . .
I shall go slowly where I walk
And when the crowds rush to beat me
I will console myself that I continue in the moment
. . . . . .
I shall walk in bare feet to connect with the earth
And when the burs and sharp rocks tear my feet
I will remember the suffering of those before me
. . . . . .
I will sing a song to heaven
And when the world is overwhelmed by chaos and pain
I choose good intention and prayerful gestures
. . . . . .
I will show the world my smile
And when fear grips my every bone and shatters my dreams
I will look kindly and love regardless
This has a sweet yearning imbued in each stanza…. an warm offering to remember that we can endure, we can be soft and hard at the same time. This is wonderful nougat.xxxx
Thank you for your beautiful response KarenSue (hugs) xxx
– © Karin Taylor
i am so moved by this piece . . . . quiet and gentle soulful suffering. great job. xx
Thanks so much yvonca, you are so special xxx
– © Karin Taylor
Your poem has made my morning Karen. Beautiful piece…
Thank you very much Anna, you made my heart smile with appreciation and joy :) xx
– © Karin Taylor
An artist can pay just as much attention to detail in the world around them through their bodies, just as they pay attention to detail in art through their eyes. Just beautiful Karin.
I think that's so true Mui-Ling, thank you so much my friend ;)
– © Karin Taylor
wonderful so very very beautiful writing gorgeous work
aw, thank you so much :) x
– © Karin Taylor
thank you so much :)
– © Karin Taylor


text:
Blow Out the Candles!
In the past year, youve journeyed to the exact same urban oasis on Biscayne Boulevard, but for a variety of reasons. On Thursdays the movies lured you, on Tuesdays free piña coladas and 18 artsy holes of minigolf called your name, and on Saturday mornings it was the promise of lush organic fruits and veggies for sale that did the trick. Which makes it hard to believe that, 366 days ago, none of that was there and your days were dull and gray. So tonight venture out one mo gin to celebrate the first anniversary of the Upper Eastside Garden.
The festivities will include more of UEGs brand of eclectic fun. From 7 to 11, therell be a free round of putt-putt, performances by artists like Perspects and Otto Von Schirach, comp Grolsch beer and vodka, a showing of a portion of Michelle Weinbergs Warehouse Plays murals, and even Lightning, a miniature horsy from Calder Race Course. Yay! Admission is 10 bucks, but the sake shots at the door are free.
Sat., March 22, 2008
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Need Help? Contact us at 800-217-6872.
Grainger, Grainger.com and KeepStock are trademarks of W.W. Grainger, Inc.
What's New
The Home Depot
Browse and shop for over 600,000 home improvement products: appliances, bathroom, decorating ideas, kitchen remodeling, patio furniture, power tools, BBQ grills, carpeting, lumber, concrete, lighting, ceiling fans and more! Plus, save with free shipping to home or store on more than 400,000 items.
The Home Depot's Pick Up In Store and Ship to Store options offers you the convenience of placing an order on homedepot.com and subsequently picking up your item(s) at a Home Depot store location. This feature not only saves you shipping charges but also helps you expedite any time-sensitive projects. Our Ship to Store features more than 300,000 items that can be shipped free of charge when you order online or in our app.
Find the closest Home Depot location by using our Store Finder. It directions, store phone number, hours of operation, and services offered (truck rental, key making, tool rental, etc..).
View detailed store maps to help you find your way to what you need. Tap on the aisle location of a product and see that item plotted on a map.
Use the barcode reader to scan an item and read what other customers have to say. Use the Home Depot app to write your own reviews and even upload an image.
Simply speak the item into our search for a fast and convenient way to find what you need.
If your GPS and location services are turned on, the Home Depot app will detect when you are in the store and provide a special store specific menu that helps you find items in the store, see local ad, and see what workshops are scheduled for that store.
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Grocery King Shopping List
** Note to existing users, if you are having trouble opening lists, please Sign out of your Sync account and Sign back in. **
Why you need this app:
★ Grocery King will save you time, money and effort every time you go out for shopping.
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★ Sync for life, NO subscription fees to pay yearly.
Top features:
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✔ Adding items to shopping lists is now simpler than ever. The new quick search not only allows you to speak or type an item and select from a bunch of matches but also to quickly edit the item without ever leaving the search box.
✔ Brand new checkout system that offers you an experience similar to how you would checkout from your retailer/store. Items, prices, discount, tax and total price are all pre-calculated and shown clearly. You can also attach a photo/barcode of a real receipt to look it up later.
✔ New History view stores all your previous shopping history sorted by shopping date along with your receipt and barcode.
✔ Quick and easy way to attach real item photos to an item, never get the wrong item again.
✔ Unit Price comparison. Now you can compare unit prices between stores so that you know exactly who is selling it cheaper.
✔ All new way to store your Store Loyalty cards, Retailer coupons & Gift cards. Receive alert notification before the cards expire.
✔ Brand new recipe view. Easily create and catalog all your recipes and their ingredients. Quickly know what ingredients you have in stock and also add to the assigned shopping list with one click.
✔ New quicker and more reliable sync mechanism. Easy one step sign-up and easy to remember email and password scheme. Sync is now fully automated but at the same time you have options to perform a forced push or pull.
✔ Automatic and continuous backup to Cloud. Your data is more secure than ever before.
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Have any questions or feedback? Please get in touch with our support team at firstname.lastname@example.com.
Ebates Cash Back & Coupons
Ebates.com pays you to shop online! Earn up to 26% Cash Back every time you shop with a FREE account! In fact, you will get a $5 bonus when you make your first purchase.
Ebates works with 1,700 stores including Sephora, JCPenney, Kohl's, Home Depot, Overstock.com, Groupon, and Walmart, so you are sure to find your favorites.
In addition to Cash Back, Ebates has thousands of great online coupons, free shipping, and special offers from its stores, so you always get the best deal.
Earn up to 26% Cash Back at over 1,700 stores including Sephora, JCPenney, Kohl's, Home Depot, Overstock.com, Groupon, and Walmart.
Activate Cash Back and easily apply coupon codes in a browser made especially for Ebates shoppers.
Access thousands of online coupons, free shipping, and special offers from its stores.
View Ebates top coupons of the week to make sure you get the most savings.
Browse stores that are offering Double Cash Back
Easy access to your favorite stores to make shopping simple.
Search for a product or scan its barcode to find out the best place to buy online after your Cash Back.
Invite your friends to join Ebates directly from the app to Earn $75! 1st Referral = $20, 2nd Referral=$25, 3rd Referral=$30!
Access your Cash Pending, Cash Back History, and Tracking Tickets to see what's coming in your Big Fat Check!
Get notified when you earn Cash Back, Double Cash Back at your favorite stores, and hot coupons.
NOTE: We request for your location to improve the shopping experience on different merchant sites. For example, at Groupon it will show you deals in your city.
Wish - Shopping Made Fun
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★★★★★ "Must have app. The clothing, suggestions and all the other wonderful stuff in here is awesome. I'm hooked." - Claudia Betancur
Amazon Shopping
* Customers are able to shop millions of products on any of Amazon's sites around the world from a single app
* Quickly search, get product details, and read reviews on millions of products from Amazon and other merchants
* Take advantage of 1-Click ordering, customer support, Wish Lists, order tracking, and more
* Scan product barcodes and images to compare prices and check availability using Scan It or search for products on Amazon using your voice
* Check out Gold Box Deals - including the Deal of the Day and Lightning Deals, and get automatically notified when new deals become available
* Shop the full selection of products available at Amazon.com
* Customers with an Android Wear smart watch can search with their voice, 1-Click buy products, and save products and ideas to their Wish List
* Send and share links to products via email, SMS, Facebook, Twitter, and more
* Sign-up for automatic shipment notifications to know when your order ships and arrives
* Buy with confidence, knowing that all transactions are securely processed
Product Description
The Amazon Shopping app lets you shop millions of products and manage your Amazon orders from anywhere. Browse and shop by department, compare prices, read reviews, share products with friends, check out Gold Box Deals, make purchases, and check the status of your orders. Comparing prices and product availability is now even easier by searching with your voice, scanning a bardcode or an image with your camera, or simply typing in your search. Never miss a deal with easy access to Lightning Deals and the Deal of the Day. You can also sign-up to get notified automatically when your order ships and arrives at its destination. The Amazon Shopping App also includes support for Android Wear. Customers with Android 4.3 and above in the US with an Android Wear watch can use their voice to search, buy products, and save shopping ideas to their Wish List. Just say "Start Amazon Shopping" from your Wear watch. With the Amazon Shopping app, you always have full access to your Shopping Cart, Wish Lists, payment and Prime shipping options, Subscribe & Save order history, and 1-Click settings, just like on the full Amazon.com site. All Amazon Shopping app purchases are routed through Amazon's secure servers to encrypt and safeguard your personal information.
Important Note Regarding Permissions
Please note that the Amazon Shopping app requires access to the following services to operate properly:
* Camera: The camera is used to scan barcodes and for Flow, a new way to search for multiple items quickly.
* Location: Location permissions are required to support the convenience store delivery service offered by Amazon in France and Japan. Customers in those locations can request delivery to a convenience store near their current location. This service is not available in other countries supported by the Amazon Shopping app.
* Account: Account permissions are used for integration with Facebook and other social networks you have connected to your device to allow you to share products with friends and family.
* Phone calls: within the app you are able to place a call to Amazon Customer Service. Tap Menu > Help & About > Contact Us > Call Customer Service, and we will place the proper number in the phone app and dial it.
* Phone status & local storage permissions are required to support notifications in China.
* Read / Write USB Storage
OS Requirements: Requires Android OS 2.3 or higher and a rear-facing camera. The Amazon App for Tablets is available on Google Play. Search for "Amazon Tablet" to install the app and begin shopping.
Shop boohoo
*The latest from boohoo.com. On Trend. On Price. Online. Fashion and inspiration at your fingertips 24/7
*Don't miss a trick with our amazing clearance on many latest trends and fashion clothes. Check out our clothes sale and clearance bargains now!
ToS: This is not the official boo hoo app, nor is it affiliated with the company or any of its partners. The app just allows you to view the website in a clear mobile format.
Amazon India Shopping
• Gateway to India's Largest Online Store
• 100% Purchase Protection: 24x7 customer service support, and a globally recognized and comprehensive 100% purchase protection provided by Amazon's A-to-Z Guarantee.
• Save Big Every Day: Shop for Today's Deals, Happy Hour Deals and exclusive App-only Deals
• Secure Payments: Shop using your Credit/Debit Card, EMI or Net Banking knowing that all transactions are securely processed.
• Track your orders: Get up-to-the minute notifications on the status of your orders
• Quick Search: Search by product name, category, brands, or simply scan a barcode to instantly check availability and prices
• Rich Catalog Imagery: View the product in multiple angles, with options to zoom for finer details
• Personalized Recommendations: Get suggestions based on your ratings, likes and shopping trends
• Share Product links with your family & friends via email, SMS, WhatsApp, Facebook, Twitter, and more
• Easy Returns: Returns are easy with our Online Returns Support Center
Please note that the Amazon Shopping App requires access to the following services to operate properly:
• Camera: The camera is used to scan barcodes
• Account: Account permissions are used for integration with Facebook and other social networks you have connected to your device to allow you to share products with friends and family
• OS Requirements: Requires Android OS 2.3 or higher and a rear-facing camera.
Amazon App allows you to conveniently shop on-the-go; browse & search for your desired products and brands, view recommendations & customer reviews, add to wish list & cart, complete the purchase using the available payment options and track the status of your orders. The app supports barcode scanning for quick price checks.
New customers can sign up for an account using the Amazon App, while existing customers can login using their Amazon.in credentials to access the same account that they use on the website.
Shop anywhere with ease and confidence from millions of products across a broad range of categories including Books; eBooks & Tablets; Movies & TV shows; Kindle Devices, Computers & Accessories; Mobiles & Accessories; Consumer Electronics; Toys & Games; Baby Products; Health and Personal Care products; Watches; Fashion Jewelry; Home & Kitchen products; Beauty Products; Video Games; Music; Luggage & Bags; Handbags & Clutches; Sports, Fitness & Outdoor equipment; Shoes; Men's, Women's & Kid's wear; Pet Supplies and more.
Enjoy Amazon's guaranteed next-day delivery on products Fulfilled-By-Amazon (FBA).
Benefit from a safe and secure ordering experience, convenient electronic payments, Cash on Delivery, no-risk hassle-free returns policy, Amazon's 24x7 customer service support, and a globally recognized and comprehensive 100% purchase protection provided by Amazon's A-to-Z Guarantee.
With eBay mobile you can:
✓ Search, Bid, Buy or Make offers on unique items from around the world
✓ List your items for sale in minutes
✓ Use the barcode scanner to find items, compare prices or start a new listing
✓ Get customizable alerts about your eBay items and activity
✓ Track your packages
✓ Leave feedback
✓ Read and respond to eBay messages
✓ Follow your favorite searches and sellers for quick access to the latest inventory
✓ Revise your listings and manage your eBay business on the go
✓ So much more. We'll spare you the details so you can start shopping now.
English, French, Italian, German, Spanish, Portuguese, Russian, Polish, Dutch, Flemish
eBay widgets on your home screen, available now in the Google Play store!
Thanks to all our loyal fans for your support and advice! For issues, ideas and suggestions (or just to tell us you love us), email us at firstname.lastname@example.com or join the discussion at http://getsatisfaction.com/ebaymobile.
Wait, you need access to what?
We know it can be a little scary to see applications requesting permission to access areas of your device functionality, so we're trying to be as transparent as possible. Here are some answers to common questions about what we do with these permissions:
YOUR ACCOUNTS: We need access to the accounts on your device so that we can get it connected with Google Cloud Messaging and send you notifications on your activity.
SYSTEM TOOLS: We use this permission in order to wake up the device in order to send you notifications. The device will return to sleep mode automatically.
LOCATION: We are now able to surface more relevant search results to you based on your location.
NETWORK COMMUNICATION: Share items with friends or good looking strangers using NFC. Just enable NFC in your device settings, then hold your phone up to someone else's and "Beam" your item to them!
CAMERA: Some users are still wondering why this application needs camera access so let us lay your fears to rest. We need access to use the device camera to allow you to scan barcodes for comparison shopping or starting a new listing, to take photos when listing an item and to attach photos to an eBay message.
Myntra-Online Fashion Shopping
online shopping with you everywhere you go, and get all your favourite fashion merchandise (clothes,
footwear, accessories, beauty products, you name it) by top brands.
Browse through 1,60,000+ product styles from 1000+ brands instantly on the Myntra shopping app.
Discover the latest trends in lifestyle and shop for clothes, kurtis, sarees, shoes, T-shirts, jackets, jeans,
bags, skirts, dresses, jewellery, watches, wallets, footwear and much more. With the app, you have
access to free styling tips from our fashion experts, and hot offers and deals on all your favourite
Get the best online shopping experience with Myntra's cool new app that offers you FREE Shipping, 30-
day hassle-free returns guarantee, and a convenient cash-on-delivery option. And these are just some of
the reasons that make Myntra India's favourite fashion shopping destination.
The online collection of products across categories includes:
• Men's shopping - accessories, apparel , bags, beauty products, clothes, ethnic wear , kurta pyjama
sets, sherwani, footwear, formal wear, formal shoes, fragrances, grooming products, jeans , jewellery,
kurtas, pyjamas, polo T-shirts, shirts, shoes, sports shoes, running shoes, casual shoes, sunglasses,
trousers, T-shirts, wallets, watches, winter wear
• Women's shopping - anarkali suits, apparel, bags, beauty products, blazers, capris, casual shirts,
churidar, clothes, dresses for girls, dresses, dupatta, ethnic wear, fashion accessories, footwear, formal
dress, fragrances, handbags, jeans, jeggings, jewellery, kurtas, jumpsuits, killer jeans, kurtas, kurtis,
leggings, lehenga choli, lehenga, lingerie, long skirts, maxis, party wear, printed leggings, salwar suit,
sarees, Nike shoes, sports shoes, running shoes, casual shoes, shorts, shrugs, skirts, sleepwear, suits,
sunglasses, tops for girls and women, trousers, T-shirts, tunics, wallet, watches
• Kid's shopping - footwear, clothes, apparel, kids' watches, kids' footwear, kids wear, dresses for girls,
infant wear, accessories for kids, babies, toddlers and infants, accessories for boys and girls, kids' shoes
• Popular brands - Adidas, Aviator, American Tourister, Arrow, Being Human, Biba, Casio, Chumbak,
Daniel Klein, Escort, Fabindia, Fastrack, Fifa, Fila, Forever 21, Giordano, Inkfruit, Jockey, Lee, Lee Cooper,
Levi's, Maxima, Nike, Petrol, Peter England, Puma, Ray-Ban, Reebok, Red Chief, Skybags, Sonata, Tommy
Hilfiger, United Colors of Benetton, W, Wildcraft, Woodland, Wrangler, Yepme
• Find products you love: Choose from a vast collection of clothes, dresses, shoes, and fashion
accessories for men, women, teens and kids.
• Refine your search based on popularity, discount, prices, colours, sizes and more using sort and filter
• Avail massive discounts: Easily add your Myntra coupon code directly in the app. Also, get notifications
on best deals and offers.
• Sharing made easy: Get style suggestions from your friends by sharing on WhatsApp, Facebook,
Twitter and email.
• Shop for premium and designer brands, including the likes of Guess, Steve Madden, Timberland, Boss,
Desigual, Diesel, DKNY and a lot more.
• Fast and Secure Checkout: Pay by cash-on-delivery, net-banking, or credit and debit cards options.
• Wishlist: Save stuff for later by adding to your wishlist straight from the app.
• View detailed product information with rich images and style notes from our fashion editors.
• Log in seamlessly using Facebook and Google.
So, what are you waiting for? Download the best online shopping app and get shopping now!
Suggestions/feedback are always welcome. Drop us a line at email@example.com
Overstock - Shopping App
• Shop sales, daily deals, and weekly promotions wherever you are in the U.S.
• Receive notifications for exclusive coupons and daily deals
• Find the biggest discounts on brand-names at up to 70% off MSRP
• Check out with Google Wallet
• Easily contact our award winning Customer Care representatives with shopping or order questions
* Free standard shipping on orders $50 and up (applies to U.S. orders only. For expedited shipping, additional charges will apply. Offer applies to the lower 48 states. Offer excludes Alaska, Hawaii, APO/FPO and international orders. Sales tax and charitable donations are excluded from subtotal for purposes of this offer).
Although the app does require certain permissions, we will NOT have access to your personal information and we do NOT track or collect any information from other apps.
Supports Android 4.0 (Ice Cream Sandwich) and higher.
Geek - Smarter Shopping
- Save items and shops as favorites to revisit them later
- Create and manage lists while you browse
- Get notified the minute an order ships
- Explore curated recommendations tailored to your taste
- Now available in English, German, French, Dutch, Italian and Spanish
If you have an Etsy shop, our free Sell on Etsy App is also available on the Play Store. It has all the tools you need to manage your shop: process orders, add listings, view your Shop Stats and more.
Support: http://www.etsy.com/help/
Report bugs: https://www.etsy.com/teams/7720/bugs/discuss/
Site status: http://etsystatus.com/
About Etsy:
Etsy is a marketplace where people around the world connect to make, sell and buy unique goods. Our mission is to reimagine commerce in ways that build a more fulfilling and lasting world.
Forever 21
Available on Android phones and tablets, the official Forever 21 app lets you play games, scan barcodes, shop, swipe through style inspirations, get exclusive mobile offers, and find your nearest store.
Features include:
- PLAY: Weekly word searches, puzzles and games to keep your sense of style sharp!
- #F21XME: Check out how F21 fans around the world are styling their outfits in the #F21XME gallery, then submit your own!
-BARCODE SCAN: Can't find your size in store? Want to show off the new outfit you just bough to your social circle? Just scan the barcode to shop, share, and save.
-LOOKBOOK: Swipe through looks created by our top stylists. Share the ones you love, or shop the look to make it your own.
-DEALS: All our current sales, promotions, and exclusive mobile offers in one place. Plus, it's badged on the home screen so you know how many you have.
- GPS STORE LOCATOR: Use your current location to find the nearest Forever 21, what lines it carries and how late its open.
- NEW ARRIVALS: We're adding hundreds of new items a day! Be the first one to see them come in.
- SHOP: Browse and buy on the go with the shop section.*
The perfect tool for holiday shopping, or for just finding the right dress for a big night out, Forever 21 mobile has you covered.
*Available for shopping only in the US. Other countries to be added in the future
We'd love to hear from you! Email your feedback about our app or any questions to firstname.lastname@example.com.
***App optimized for Android's 3.1 operating system and later. Earlier versions of Android may be incompatible and experience some functional issues***
AliExpress Shopping App
Our customers have access to great products at incredible prices. Buying directly from sellers in China means you can buy the same products you can get anywhere else, but for much lower prices!
Buyers on AliExpress have access to a choice of 100+ million products. You can find just about anything you wish for among our large product selection. You can get anything from clothing, shoes and accessories, to car parts, electronics and baby care items. You can even find a range of different customizable products too.
Another reason to fall in love with AliExpress is that we give free shipping on over 75% of our products!
In addition, the AliExpress app offers great value with daily deals, regular promotions and thousands of coupon giveaways.
The AliExpress app comes packed with features and functions designed to give you a safe and joyous shopping experience. Use our app to:
★Shop by product category
★Conveniently search for products with search filters
★Read buyer reviews
★Create Wish Lists
★Share products with friends via email, Facebook or other social media
★Make secure online payments
★Track your packages
★Receive instant updates on your order status
★Manage your orders
★Chat with sellers
★Get Buyer Protection on all your purchases
The AliExpress app is for people who love convenient shopping without the extra cost. Find out what value we've got in store for you!
Language Support
The AliExpress App is available in English, Spanish, Portuguese, Russian, Turkish,Italian, Hebrew, German, French, Thai and Bahasa Indonesia.
Get in touch with us, we love hearing from you!
If you find any areas for improvement while using the app, or have any ideas to make shopping on the app even more convenient, please let us know! You can leave feedback in the app by selecting "More Options" -> "App Feedback", or leave feedback in Google Play.
We look forward to hearing from you!
AliExpress.com Overview
Launched in April 2010, AliExpress is a global retail marketplace targeted at buyers worldwide. The platform enables consumers from around the world to buy directly from wholesalers and manufacturers in China and have access to a wide variety of products at competitive prices. AliExpress is a business within Alibaba Group.
AliExpress offers over 100 million fascinating product listings from a range of over 25 different categories including the following: Apparel & Accessories, Automobiles & Motorcycles, Phones & Telecommunications, Computers & Networking, Consumer Electronics, Beauty & Health, Lights & Lighting, Luggage & Bags, Shoes, Toys & Hobbies, Watches, Jewelry, and many more.
AliExpress makes shopping easy and convenient all around the world.
The zulily app is your on-the-go source for all things adorable. Our featured brands change every day, so you never know exactly what you'll find for you and your little one. But you can be sure it's worth a look. We're obsessed with making you smile.
The zulily app offers quick, free access to sweet style
• Something special every day
• Open at 6am PST
• Boutique brands at up to 90% off retail prices
• See what's coming soon and set alarms
• Invite new members and earn credit
• Share finds with your friends
Not a zulily member yet? No problem! It's free and you can join from the app. Take a peek into our whimsical world. See what you see. We think you'll love it!
By signing in to our app, you agree to the zulily Terms and Conditions & our Privacy Practices
Snapdeal Online Shopping India
Enjoy great online shopping experience on your mobile device with official Snapdeal Android app. Everyone can now shop online anywhere and at anytime! Featuring a user-friendly and extremely fast interface, the app helps users to browse through multiple product categories, view reviews, compare prices, specification and features before making any purchase.
Now you can also get extra Cash back every time you shop on Snapdeal mobile app. Savings are now in your hands!
Install the Snapdeal app for a secure shopping experience at your finger-tips anywhere & anytime. Available for FREE at Google play store for shopping lovers, the ready to download app is compatible with Android 2.2 operating systems and above. Shop from favorite brands and get your order delivered by free shipping service to 4000+ cities within India.
About Snapdeal:
With over 20 million members, Snapdeal.com is the most popular e-commerce destination for millions of internet users across India. The site features a wide assortment of quality products from number of Indian & International brands.


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|All Content
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Originally published on Wed May 30, 2012 6:51 am
Mitt Romney won the GOP presidential primary in Texas Tuesday night. By some counts, that gives him the last delegates he needed to formally secure the Republican nomination. He celebrated in Las Vegas with a campaign event and a fundraiser. But his victory was overshadowed by campaign surrogate Donald Trump who has a gift for finding the spotlight.
2 Pillsbury Street, 6th Floor, Concord NH 03301 T: 603-228-8910 or 800-639-4131 F: 603-224-6052 E: email us


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Keep up the good work Jeff, and staff. I always find what I'm looking for, and price is always excellent. If shipping costs are required, it's nice...Read More ->
To: The MJM Magic team, I am very satisfied with the service your team provided for me. You handled our transaction in a very effecient and...Read More ->


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Check out the new, mobile-friendly WineSpectator.com!
The balance shown by the best 2011 white Burgundies indicates that the wines will develop nicely. However, wine is full of surprises, and the 2011s have plenty of both charm and substance to offer. Wine Spectator's Bruce Sanderson explains.
For the full article, check out the new issue of Wine Spectator, on newsstands August 19, 2014.
Do you have a Wine Spectator magazine subscription? Save 50% on your Online Membership right now!
Passionate about wine? Wine Spectator magazine is looking for an enthusiastic copy editor in the New York office.
Sips & Tips | Wine & Healthy Living
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New! Ratings Flash | New! Unfiltered
» View samples
» Or sign up now!
» Manage my newsletter preferences
The marketplace for all your wine needs, including:
Wine Storage | Wine Clubs
Dining & Travel | Wine Auctions
Wine Shops | Wine Accessories


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Your Retro Candy and Gift Store
Home | About Us | Contact Us | Sign in | Track Order | Shipping | View Cart
Candy Buffets and Wedding Favors
Delicious Wedding Candy is the perfect way to accent any wedding. Edible Wedding Candy Favors are creative, inexpensive and loved by guests old and young. Our variety of bulk candies and colors will make your candy buffet a sure hit! Create your own candy buffet by matching the color scheme of your special day with Candy by Color. Fill up favor bags, boxes or jars for wedding receptions, engagement parties and bridal showers.
Orders are shipped the same business day when placed by 4pm EST and come with a 100% guarantee!
Like us on Facebook, follow us on Twitter and check out our Candy Blog for all the latest candy news, events and Candy Crate specials.


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Off-Topic » The First Thing That Comes to Your Mind When I Say...
Has one of the shortest mini-bio sections that I have seen here on AV.
Was the first person to post on this thread in over 22 hours
Has done some fantastic work in the Wiki over the past few years.
@reiyo: Going the wrong way, bub :p
@reiyo: Nope.
Hmm...23, I'd say?
@flashback180: Nope :p
@Bigheart711: getting colder, man lol
Has one of "the cutest" endcards in his mini-bio section :P
@Bigheart711: No, unfortunately
Hmm...20? *shrugs*
@JimeeJo: Nope
Hmm...23, perhaps?
Hmm...21? *shrugs*
Appears to be a fan of Revolutionary Girl Utena, based upon his work on the wiki pages for the series.
Had to think this one over for awhile. Both are pretty awesome and make interesting additions to various anime and manga series, but only one can take my vote here today.
Finals: Succubus over Vampire
Is a user of many avatars (some awesome, some creepy)
Submissions can take several hours to be approved.Save ChangesCancel


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- For the Media
- News Release Archive
- A Challenging 5K Obstacle Race for All Ages
- A Season of Gratitude
- Annual Holiday Concert Set the Mood
- AOTA Hill Day 2014
- Apply for FREE at Information Night
- Art Committee Selects First Painting for the Elsa and Herschel Rubin Art Fund
- Back to School Shopping
- Budding Drama Club Seeking New Members
- City Center Stands Out in Salem
- Concert will put you in a "Merry Mood for Christmas"
- Disaster Training Held at Kent State East Liverpool
- Earth Day 2014
- EL 100 Club Seeking New Members
- FlashDash
- Free Health Fair This Saturday at the Calcutta YMCA
- Get Prepped to Present Your Research - 10th Annual UGR
- Have You Heard About S.G.A.?
- Horticulture Students Learn from Industry Experts
- Insurance Studies Preps for Gamma Iota Sigma Charter
- Kent's Role in Cross-County Basketball Game
- Kent State Closed Dec. 24 - Jan. 1 for Holiday Break
- Kent State East Liverpool Celebrates the Naming of John J. Purinton Hall
- Kent State East Liverpool Holds Annual 100 Club Reception
- Kent State East Liverpool Hosts Domestic Violence Discussion
- Kent State East Liverpool Recognizes Outstanding Students
- Kent East Liverpool's Student Government Holding Blood Drive
- Kent State Regional Campuses to Automatically Award Associate Degrees to Bachelor's Degree-Seeking Students Who Complete
- Kent State Salem Receives Ohio's First Chapter of Gamma Iota Sigma for Insurance Studies Program
- Kent State Salem Students will Showcase Research Projects
- Kent State University at East Liverpool is starting a Yoga Club
- Love Develops on the Salem Campus
- Nearly 700 Blood Pressures Assessed By Student Nurses
- NCSF Personal Training Course Offered at the East Liverpool Campus
- New Club Focused on Healthy Bodies and Minds
- Nursing Department Volunteers at Health Fair
- Nursing Groups Forming at the East Liverpool Campus
- OTA Students Volunteer at Schizophrenia Walk
- Polar Express Party to be Held at East Liverpool Campus- Dec. 6
- President's and Dean's Lists Announced for Fall 2014
- PTA Students Continue Tradition
- Radiology Information Sessions at Kent State Salem
- Radiology Students, Staff Support Charity Walk
- Rural Scholars Hold Summer Workshop
- Rural Scholars Learn at Waste Management Facility
- Rural Scholars mentors present Justice Talking
- Salem Earns Tree Campus USA Distinction
- Salem Honors Students Visit Kent Campus
- Salem Psychology Club Visits Area Museum
- Salem Rotary Helps Discovery Garden Grow
- Salem Students Shine at Research Conference
- Serving it up on Fat Tuesday
- Slipping, Sliding and Slogging Through FlashDash
- Students Urge Ohio Officials to Honor Moses Fleetwood Walker
- Studying Insurance in Indianapolis
- Third Annual Asian Culture Fair Held at Kent State East Liverpool
- Welcome President Warren
- White House Representative Holds Discussion at Kent State East Liverpool
- Zombies in the Park 5K- Saturday, October 18
- Kent Salem Hosting State Research Conference
Kent State University Panel Discussion Will Explore Puerto Rico StatehoodPosted Jan. 28, 2013
Kent State University's College of Arts and Sciences, and the Division of Diversity, Equity and Inclusion are sponsoring a panel discussion titled "Puerto Rico: The 51st Star On the U.S. Flag?" on Jan. 31, from 6 to 7:30 p.m. in the Kent Student Center Kiva. A dessert and coffee reception will follow the discussion in the Multicultural Center, Room 206 of the Kent Student Center, which is directly above the Kiva. The event is free and open to the public.
Supported by the Hispanic Alliance Inc., Kent State Admissions, and the Spanish and Latino Student Association (SALSA), the discussion will provide participants with the opportunity to explore the complex issue from diverse angles. The history of Puerto Rico's connection as a U.S. territory and the arguments for independence, status quo and statehood are all aspects influencing the issue to be discussed by the panel.
Cleveland-area trial lawyer and Kent State President's Ambassador José C. Feliciano will moderate the panel discussion.
"This forum will present a discussion focusing on the historic statehood vote by Puerto Rico in the fall 2012 election," says Joseph Ortiz, Ph.D., geology professor and provost faculty associate for Kent State's Division of Diversity, Equity and Inclusion, who will serve on the discussion panel.
Other panel members include Jose E. Lopez, adjunct professor and executive director for the Institute of Puerto Rican Arts and Culture at the University of Illinois at Chicago; Juan Molina Crespo, executive director, Hispanic Alliance Inc., in Cleveland; Amoaba Gooden, Ph.D., chair of Kent State's Department of Pan-African Studies; David Kaplan, Ph.D., professor in Kent State's Department of Geography; and Elizabeth Pryor-Smith, Ph.D., history professor at Kent State.


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Mark Seckinger
President, Hardin Memorial Hospital
Mr. Seckinger was named President of Hardin Memorial Hospital in April 2001.
Prior to being named as president of Hardin Memorial Hospital, Mr. Seckinger held various positions with Doctors Hospital and most recently was the Senior Operational Officer at Doctors Hospital and was the President of Doctors Hospital in Nelsonville since 1983.
Before joining Doctors Hospital, Mr. Seckinger began his career in Healthcare at Mercy Hospital in Portsmouth, Ohio. Mr. Seckinger received a bachelor's degree in Industrial Technology from the College of Engineering at Ohio University.
2015 All rights reserved. Privacy Policies


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Arizona State University Research Technician Interview Questions
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Interviews for Top Jobs at Arizona State University
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2 Candidate Interview Reviews Back to all InterviewsSort: Popular Date Difficulty
Research Technician Interview
I applied online. The process took 2 weeks – interviewed at Arizona State University.
Applied online and received email and phone call a week later to do a phone interview. Phone interview focused on what the position would entail and my resume, research background, and interest in position. After phone interview, received email asking me to come in for a tour of facilities and do a panel interview. Interviewers were professional, easy-going, and very knowledgeable.
- No difficult questions - just questions about research background and abilities and any concerns about the job Answer Question
Other Interview Reviews for Arizona State University
1 person found this helpful
Research Technician InterviewApplication Details
I applied through an employee referral. The process took 4+ weeks – interviewed at Arizona State University in November 2009.Interview Details
If you know someone, it is very fast an easy. It is difficult to get an interview off the street. Most jobs are created with someone internally in mind.Interview Questions
Accepted OfferPositive ExperienceEasy Interview
- Name all possible species of nitrogen off of the top of your head, and the analysis methodology you would use for each one with water as the substrate. Answer Question


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Discussions continue at the State Capitol over whether to expand protections offered by Michigan's Elliot-Larsen anti-discrimination law. That's the landmark 1976 measure which legally bans discrimination in the state based on religion, race, national origin, age, sex, height, weight, familial and marital status. Several factions have emerged. Democrats and some Republicans appear to be united behind an expansion that would protect lesbian, gay, bi-sexual and transgender persons. Other Republicans favor a measure that would not include trans persons, but include the others.
A few weeks ago, we kicked off a new series called Profiles, where we sit down for extended conversations with people in our community. Today, Current State's Joe Linstroth speaks with a young woman to find out what it was actually like for one transgender person to undergo the transition from being a man to a woman.
More than 65 elected officials from all over Michigan are supporting proposed state legislation to give gay and transgendered stronger legal protections.


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Number of Pieces: 1
Finish: Antique, Polished
Material: Crystal, Brass, Rhodium
Decorative Accents: Crystals
Closure Style: Open
Chain Style: Cable
Protective Qualities: Tarnish Resistant
Care and Cleaning: Wipe Clean With a Dry Cloth, Avoid Excessive Heat, Avoid Household Cleaners, Wipe Clean
Includes: Gift Box
Chain Dimensions: 7.0 " L x 4.0 mm. W
Accent/Pendant Dimensions: 6.0 mm. H x 6.0 mm. W
Weight: 0.03 Lb.
Choking Hazard: no_warning_applicable
other Info.
- Online Item #: 14632817
- Store Item Number (DPCI): 215-03-1832
- Made in the USA


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Jigger Cube
Candlestick Maker
Why buy candle holders, when you've got all those glasses sitting around.
$30 at Cooper Hewitt | Buy
Newton Milk and Sugar Set
Cream and sugar in one sleek container.
$69 at Greener Grass Design | Buy
Cord and Coil Throw
You know that needlework throw you've been working on for three years? This one's done.
$148 at Anthropologie | Buy
Petite Vases
A place to display kid-plucked dandelions, or a big, welcoming bloom.
Arcadia Votive Duo
Kimono Flower Note Cards
Leave these out so your guests can write home about your impeccable hosting skills.
$12 at Give Simple | Buy
Cora Carafe
Hargreave Carafe
Melamine Tray
A tray gives guests a place to stow their little things, and an easy way to cart them around. Now they can move their cookies, milk, travel clock, and book from the reading chair to the bedside in one swoop. Or they can easily find their wallet, keys, and phone where they left them.
$18 at Design Public | Buy
Super Shower Holder
Keeps your thirty shampoo bottles off the side of the tub but still at hand.
$26 at Urban Outfitters | Buy
Bistro Matchstrike
This heavy iron matchstrike is the fireplace tool you didn't know you needed.
Hedgehog Pad
Toothpick Pear
Brilliant Fire Extinguisher
The only fire extinguisher I've ever wanted to keep out on my counter. Safety first!
$78 at Cox and Cox | Buy
(Price converted from British pounds.)
Seven Deadly Sins Plates
It's so much easier to commit deadly sins when you have at least one hand free. Maybe start with Gluttony.
$40 at Z Gallerie | Buy
Voluminous Camilla Canisters
Use candy as a centerpiece at the grown-ups' table for a change.
$59 at Pottery Barn | Buy
(For the medium.)
Astemio Bottleholders
Nordic Rock Stone Ice Cubes
Safe Keyping
Orange Box
Ideally, you'd get rid of the clutter. But putting it in boxes that make a statement is close enough.
$36 at The Conran Shop | Buy
Book Stool
These clever straps take a pile of magazines and make them into a stool or even a side table.
Now you can finally admit that you enjoy Playboy for more than just the articles.
$39 at The Conran Shop | Buy
Nested Measuring Bowls
Use them to make a cake, or to serve up ice cream. Who knew that was a serving size?
$20 at Anthropologie | Buy
Six-Of-One Egg Caddy
Keep your hard boiled eggs in this caddy and you won't have to spend time spinning eggs on the counter to determine their edibility.
$16 at Anthropologie | Buy
Sonara Milk Saver
The porcelain base on this gadget clatters in your saucepan to let you know your soup is about to boil over.
The red flag also waves wildly in defeat. Victory is yours!
$29 at The Conran Shop | Buy
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Gary Sherwood
Nov. 11, 1936 - Feb. 10, 2007
WILLMAR -- Gary Oliver Sherwood, 70, of Willmar, formerly of Diamond Lake, died Saturday at the Bethesda Heritage Center in Willmar.
The service will be at 2 p.m. Wednesday at the First Presbyterian Church in Willmar. Burial will be at Oak Park Cemetery in rural Kandiyohi.
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Clarion Hotel
3700 East Valley Road
Renton, WA 98055
Phone: (425) 251-9591
Fax: (425) 251-0340
Outback Steakhouse
16510 Southcenter Parkway
Tukwila, WA 98188
+1 206 575 9705
Mo to Th from 04:00 PM to 10:00 PM,Fr from 04:00 PM to 11:00 PM,Sa from 03:00 PM to 11:00 PM,Su from 02:00 PM to 09:00 PMTake in the atmosphere of the Australian Outback while enjoying mouth-watering entrees and high-quality service at Outback Steakhouse. Serving dinner only, Outback Steakhouse offers an extensive menu featuring appetizers, chicken, ribs, steak, seafood, pasta, salads and desserts for moderate prices. Family-friendly, the casual restaurant has something for everyone at its numerous locations in North and South America, Europe, Asia and Australia. Outback Steakhouse also offers call-ahead seating and curbside take-away. Check website for locations and menu selections.
Earn valuable points toward free nights.