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This Global Forum is held to strengthen international dialogue on responsible business conduct and provide a platform to exchange views on how to do well while doing no harm in an effort to contribute to sustainable development and enduring social progress. The 2015 Global Forum will focus on showcasing concrete examples of action and results-oriented solutions from efforts on the ground.
This expert seminar aims to get a better understanding of the features, limitations and preliminary findings from the use of SIBs, and to a lesser extent, of DIBs in developing countries from a multidimensional and multi-stakeholder perspective.
Volume I of this series compiles the science-based consensus documents of the OECD Task Force for the Safety of Novel Foods and Feeds from 2002 to 2008. They contain information for use during the regulatory assessment of food/feed products of modern biotechnology, i.e. developed from transgenic crops. Relevant information includes compositional considerations (nutrients, anti-nutrients, toxicants, allergens), use of the plant
The world's nominal steelmaking capacity is estimated to reach 2.241 billion tonnes in 2014, more than double the capacity of 2000. The OECD is launches a database that details new investment projects in the industry by region and country in both developing and advanced economies through 2017 and beyond. The data portal makes data on steel projects in OECD countries fully accessible for the first time.
While de-industrialisation and offshoring have dominated the news about manufacturing during the past decades, recent years have witnessed a number of examples of companies re-shoring activities back to OECD economies. Policy discussions often ignore the profound changes manufacturing has undergone. This working paper addresses this issue against the background of long-term structural change in OECD economies.
Investment is one of the central engines of growth. But we don't just need investment, we need intelligent investment. We need investment that fosters green growth, we need investment that supports innovation and entrepreneurship.
This paper examines the extent, reasons and impacts of excess capacity in the global steel industry, as well as the implications of new investment projects that continue to take place at a rapid pace in many parts of the world. By focusing on new investment projects, this study intends to help governments and industry better understand the extent to which global steelmaking excess capacity may evolve in the future.
Cette édition de la publication Statistiques l'OCDE STAN pour l'analyse structurelle 2014 est un outil utile en matière de recherche et d'analyse économiques internationales. Elle reflète les grandes tendances des diverses branches d'activité et souligne les liens qui les unissent. Elle comprend des mesures d'activité industrielle suivantes : production, valeur ajoutée (en prix courants et constants), formation brute de capital
New approaches are needed for addressing social and economic challenges, including new models of public and private partnership which can fund, deliver and scale innovative solutions from the ground up.
English, PDF, 1,007kb
The growing gap between global steelmaking capacity and demand has led to a deterioration in the financial situation of steelmakers, and has raised concerns about the longer-term economic viability and efficiency of the industry. Although excess capacity has increased significantly since the financial crisis, and despite slowing demand growth in global markets, new investment projects continue in many parts of the world.


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Political - Page 7
Do Politicians Talk Too Much About Religion? — Survey of the Day
From Rick Santurom's faith based run for president to current commander-in-chief Barack Obama actually invoking Jesus more than his born-again predecessor George W. Bush, we've been hearing a lot of religion talk over the last few years from our politicians.
Supreme Court Rules For Idaho Couple In EPA Suit
Sarah Palin Will Not Run for President
Sarah Palin has finally ended months of speculation and announced she will not seek the GOP nomination for president.
The former Alaska governor and 2008 vice-presidential candidate issued a statement that read in part, "As always, my family comes first and obviously Todd and I put great consideration into family life before making this decision. When we serve, we devote ourselves to God, family and country. My decision maintains this order."
Bristol Palin Slams McCain Family In New Memoir
Seems the gloves are off between the progeny of former political allies John McCain and Sarah Palin.
While promoting her memoir, 'Dirty Sexy Politics,' popular blogger Meghan McCain talked about the Palin family in terms that were a bit less than glowing.
Jill's Take: Idaho State Senator Arrested for Drunk Driving and Grand Larceny
Jills says... I was shocked to see this!! And he is chairman of the Regional Substance Abuse Authority Legislative Committee.
"John McGee, a four-term Republican state senator from Idaho, was arrested early Sunday morning on charges
What State Has the Most Politicians With College Degrees?
How can a state with so many smart people in charge have so many financial problems?
Nearly 90 percent of all legislators in California have a bachelor's degree or higher, the highest percentage of any state legislature in the US. Of course, considering the well-known money issues plaguing the state, maybe it's time voters elect someone who majored in economics.
Americans Angry At Current State of the Country: Survey
Newt Gingrich Running for President
Former Speaker of the House Newt Gingrich is officially running for President.
The Republican figure confirmed his long-awaited announcement on Wednesday in a video posted to YouTube, in which he said, "I believe we can return America to hope and opportunity ... There's a much better American future ahead."
USA Victory Rally – What You Missed!
The USA Victory Rally hosted by Townsquare Media had a turnout of approximately 60 people all eager and ready to celebrate the death of Osama Bin Laden and the victory of the United States!
Flags and bumper stickers were given out to everyone at this celebration, and everyone waving their flags to the music celebrating this great country was incredible

subset: commoncrawl


text: Kid Catches Baseball With His Popcorn Bucket! [VIDEO][POLL] By Lisa Lindsey July 3, 2012 8:50 AM Share on Facebook Share on Twitter andrewmalone/flickrBaseball! It's always fun to see someone in the stands catch a ball. Here's a great video of a kid catching a foul ball with his popcorn bucket at a Houston Astros game last week. Your browser does not support iframes. Have You Ever Caught a Ball at a Baseball Game? Filed Under: houston astros, kid catches baseball with popcorn bucket, poll Category: Videos Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of Eagle 106.3 Recommended For You Around the Web


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National Symphony Orchestra: Christoph Eschenbach, conductor / Hungarian Dances
Friday, March 09, 2012,
The Music of Budapest, Prague, and Vienna continues with Christoph Eschenbach conducting the NSO in "Hungarian Dances," a collection of works by composers Bartók, Kodály, Liszt, and Brahms.
- Concert Hall
- $20.00 - $85.00
Please use the event calendar to search for current events.
Program and Notes
- Béla Bartók
- Romanian Folk Dances
- Zoltan Kodaly
- Dances of Galánta
- Franz Liszt
- Mephisto Waltz No. 2, S. 515
- Béla Bartók
- Suite from The Miraculous Mandarin, Op. 19
- Johannes Brahms
- Hungarian Dance No. 1
- Johannes Brahms
- Hungarian Dance No. 3
- Johannes Brahms
- Hungarian Dance No. 5
- The Music of Budapest, Prague, and Vienna An Interactive Exploration of the History & Culture of Central Europe
- About National Symphony Orchestra at the Kennedy Center
Watch and Listen
Understanding the Music: Bartók's Romanian Folk Dances
From the Gift Shop
David and Alice Rubenstein are the Presenting Underwriters of the NSO.
The NSO Music Director Chair is generously endowed by Roger and Vicki Sant.
General Dynamics is the proud sponsor of the National Symphony Orchestra Classical Season.
The Blue Series is sponsored by United Technologies Corporation.
The Music of Budapest, Prague, and Vienna
Presenting Underwriter HRH Foundation
Additional support is provided Noémi and Michael Neidorff and the Centene Charitable Foundation, The Honorable Nancy G. Brinker, and State Plaza Hotel.
International Programming at the Kennedy Center is made possible through the generosity of the Kennedy Center International Committee on the Arts.
This project is supported in part by an award from the National Endowment for the Arts.
This event has already closed.
Please use the event calendar to search for current events.


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Made of non-woven felt insulation and a full-length heat barrier, these gloves are ideal for intermittent handling of objects up to 400°F. Two-piece construction eliminates outseams for better comfort, dexterity and flexibility.
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108-4250 - Lexa Dust Goggle Gear - Large
Large Lens provides a wider view of the work area than traditional impact goggles and includes vent channels at top & bottom for improved airflow and comfort Black frame with clear lenses DX™ anti-fog hard coat guards against fogging, scratching, static and chemic...
21-10235 - 15" Heavy-Duty Scissor-Style Tongs
These heavy-duty tongs are useful for reaching into deep containers and pots. Kool-Touch® insulated handle to use in warmer settings without discomfort.
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This kit helps minimize the risk of burns or shocks while cleaning and charging batteries. Fully equipped and portable so you can take it to the jobsite or use at home or in the shop.
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108-5245 - VHB™ Tape - 1/2" x 36 Yards - Dark Gray
A firm double-sided, pressure-sensitive foam tape with a PE film liner. Excellent temperature resistance and useful for bonding metals and other high surface energy materials.
19350 - Two State Wrist Strap Touch Tester
Connects to utility ground when plugged in-quick, easy installation and grounding of both wrist straps and table mats.
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MCM Cat 57, Page 1083
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IT Governance, ... and Compliance
Information Security
Get Rid of the Fear: A Practical Approach for Using DLP to Manage Risk
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Get Rid of the Fear: A Practical Approach for Using DLP to Manage Risk
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Andrew Forgie, CISSP Websense Director of Product Marketing – Data Security
CIOs don't need to be convinced about data loss protection. Compliance, financial implications, brand reputation are all factors that drive this need. The real problem is that people are afraid of failure and wasting time, money, resources. They've heard about the operational nightmares, the complexity and failed deployments over the last several years. In addition, RSA and Symantec both had data stolen publically, implying the integrity of the solutions' value is uncertain.
During this interactive session attendees will receive valuable insight on how security works and learn the secret of understanding and communicating risk. Equipped with this knowledge, Andrew will provide a practical and measurable framework for managing risk to information assets using Data Loss Prevention.
What attendees will learn:
Guiding Principles of Security and Risk Management
Data Breach Trends from the Last 6 Years
DLP Methodology and Execution Strategy
Success Factors in Addressing the Web DLP Challenge
Apr 5 2012
45 mins
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IT Governance, Risk and Compliance
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Jannis Utz, Technical Account Manager, Qualys GmbH
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Wie Sie in drei Schritten ein klares IT-Configuration Management aufsetzen
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Die Herausforderung ist, genau diese Maschinen zu identifizieren und sicher zu stellen, dass sie korrekt konfiguriert werden und dies auch bleiben.
Lernen Sie in unserm Webcast wie Qualys Policy Compliance Ihr IT-Configuration-Management verbessern kann und damit Ihre Basis-Security stärkt und das Ganze voll automatisiert.
Erfahren Sie:
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Mar 31 2015
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Vous souhaitez en finir avec l'information dispersée à travers des centaines de répertoires partagés, espaces personnels, et disques durs locaux ?
Vous êtes à la recherche d'une plateforme collaborative tout-en-un ?
Vous êtes certainement déjà familier avec Microsoft SharePoint, mais êtes-vous sur de connaître l'étendue de son périmètre fonctionnel ?
Car si SharePoint reste une excellente plate-forme intranet, de portail web, de collaboration et de partage documentaire, SharePoint va bien au-delà de ces fonctions avec le réseau social (RSE), les outils de développement, et la gestion documentaire (de type GED).
Participez à notre webinar pour mieux comprendre la richesse de la plateforme et ses bénéfices : une collaboration unifiée et des gains de productivité à chaque niveau de l'entreprise (utilisateurs métiers, DSI, direction).
Nous aborderons également les modèles de déploiement de SharePoint (100 % cloud, hybride ou on-premises) ainsi que les limites et bénéfices de chaque configuration.
Dans un second temps, nous nous pencherons sur les questions de déploiement de SharePoint et nous découvrirons comment AvePoint, avec sa solution de migration pour SharePoint 2013 & Office 365, vous permet d'accélérer la mise en place de votre plateforme.
Nous ferons un tour d'horizon des problèmes les plus communément rencontrés pendant les projets de migration, et nous verrons en 3 points comment AvePoint vous permet notamment de les adresser :
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• Maintien de l'ensemble du contenu, des permissions et des métadonnées jugés pertinents par vos équipes.
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As a security professional, you are on constant alert for external threats. But many breaches are caused internally by incorrect configuration of IT resources, including SSL. To help improve how encryption is used, Qualys created a research project called SSL Labs to address two major problems of the ecosystem: lack of tools and documentation.
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A Zero-Day Agnostic Approach to Defending Against Advanced Threats
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In this webinar, Eric and Dave will discuss:
• How the volume of system alerts from Network Security solutions are creating lots of noise but lack context to focus on the real threats facing your data
• How to stop advanced threats – with no advance knowledge of the tools or malware – by following the attack sequence
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Kristen Wilson-Jones, RD&D CTO, Sutter Health; David Chao, Director of Industry Solutions, MuleSoft
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Sutter Health is a not-for-profit health system serving more than 100 communities in Northern California. Each year its 5,000 physicians care for more than 10 million outpatient visits and discharge more than 200,000 in-patients.
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Join us as Kristen Wilson-Jones, Sutter RD&D CTO, shares how Sutter Health has leveraged MuleSoft's Anypoint Platform in an orchestrated plecosystem of technologies to power Project RED by enabling real-time patient risk scoring, clinical workflow management and bi-directional integration with Epic.
Topics covered
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* Explosive Cybercrime growth comes from criminals leveraging the internet – how can we use that same leverage to our advantage?
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Le saviez-vous ? Vous pouvez faire cesser les attaques...
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Les applications Web sont la cible privilégiée des pirates. Leur sécurité doit donc être une priorité. Un firewall applicatif assure une protection active contre les menaces connues et Zero Day. Rejoignez-nous afin de découvrir comment le service de firewall pour applications Web proposé par Qualys associe évolutivité et simplicité via le Cloud pour bloquer rapidement les attaques, sans les coûts importants liés aux solutions classiques.
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Information Security
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30 mins
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- Transition effort, cost and impact
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Apr 16 2015
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45 mins
Grayson Milbourne, Security Intelligence Director
This presentation provides an overview of the threats against a wide range of organizations and individuals during 2014. This overview is based on research and analysis conducted by the Webroot Threat Research team. The report includes analysis of IP addresses associated with malicious activity, details on the reputation of URLs by category and location, phishing detection statistics, insights into file reputation and encounter rates with malware and PUAs and information on mobile app security for Android devices. All data presented comes from Webroot's Intelligence Network and was observed during 2014.
Next-Generation Security for Amazon Web Services
Apr 16 2015
4:00 pm
60 mins
Matt Keil, Product Marketing, Palo Alto Networks
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4:00 pm
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Dr. Sameer Bhalotra, Former White House Director; Chris Petersen, CTO; Robert F. Lentz, Former CISO for the Dept of Defense
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Learn about:
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Apr 14 2015
6:00 pm
45 mins
Chuck Easttom, Computer Scientist, Author, and Inventor
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Apr 14 2015
5:00 pm
60 mins
Booz Allen Hamilton
Vendor Risk Management
The Dark Side of Anonymizers: Protect Your Network from the Unknown
Apr 14 2015
5:00 pm
45 mins
Joanna Burkey, DVLabs Manager, HPSW HPN Security - Tipping Point
While anonymizers can serve a positive purpose by protecting a user's personal information by hiding their computer's identifying information, their use in your network environment can be dangerous. Anonymizers can evade enterprise security devices, and their misuse can make your organization susceptible to malware and unwanted intrusions. Attend this session to learn how you can detect and block elusive anonymizers from wreaking havoc on your network.
Industrial Control Systems Cyber Security: It's Not All About Stuxnet
Apr 14 2015
3:00 pm
45 mins
Dr Damiano Bolzoni, CEO & co-founder, SecurityMatters
Recently cyber attacks against Industrial Control Systems (ICS) used by
utilities and other Critical Infrastructure organizations have hit the
newlines worldwide. Stuxnet is the best known cyber attack against an
industrial installation, but it's not the only one.
But what if cyber attacks were not the biggest threat to industrial
networks and systems? Although malware is still a major point of
interest, the sword of Damocles for critical industrial networks is
represented by system misuse performed by disgruntled employees,
contractors and vendors, as well as unintentional mistakes,
network and system misconfiguration; all this could lead to the
divergence or failure of critical processes.
In this talk we will reshape the concept of ICS cyber security and will present our vision for a comprehensive approach to cyber security for ICS.
All About the Thousands of 2014 Vulnerabilities - From Secunia Research
Apr 14 2015
3:00 pm
45 mins
Kasper Lindgaard, Director of Research and Security, Secunia
Every year, Secunia Research releases a review of the global vulnerability landscape, based on their large vulnerability database and data from the Secunia Personal Software Inspector (PSI) user base.
The data in this research provides security professionals around the world with perspective on the impact and evolution of the threat landscape and what has trended throughout the year.
In this webinar, Secunia's Director of Research and Security Kasper Lindgaard will discuss the data presented in the Secunia Vulnerability Review 2015 and answer questions.
The review itself was released on March 25.
You can download a copy of the review on our website:
Key takeaways:
- The number of vulnerabilities and zero-days detected in 2014
- How quick vendors are to respond to vulnerabilities
- Which programs are more vulnerable
- How products bundled with open source applications and libraries affect security
It Wasn't Me, It Was Bennett Arron
Apr 14 2015
10:00 am
45 mins
Bennett Arron, Comedian, Author & Identity Theft Speaker
Several years ago, award-winning writer and stand-up comedian Bennett Arron was in serious debt. He owed thousands of pounds to mobile phone companies, catalogues and department stores. Only it wasn't him. Bennett was a victim of Identity Theft, the fastest growing crime in the UK. This theft resulted in Bennett and his pregnant wife becoming penniless and homeless.
Years later, Bennett wrote a comedy show about his experience. The show was critically acclaimed at the Edinburgh Festival and led to Bennett being asked to direct and present a Documentary for Channel 4. The Documentary, How To Steal An Identity, was Pick of The Week in The Guardian and The Telegraph and was called 'Fascinating and Disturbing' by the TV Times. It went on to be shortlisted for a BAFTA.
In the Documentary, Bennett proved the ease of ID theft, by first stealing the identities of the general public and then stealing the identity of the then Home Secretary, Charles Clarke.This action resulted in Bennett being arrested in a dawn raid by Scotland Yard and given the code-name Operation Hydrogen.
Bennett has recently written a memoir on the subject. This book, which has received several 5 star reviews, is not only a disturbingly true yet funny account of what it's like to have your identity stolen and but also reveals the devastating consequences of making a documentary 'in the public interest'.
He has performed as a speaker at many corporate events around the world and he was the Guest Speaker at the International Fraud Convention in Italy, the International Congress On Anti-Fraud & Anti-Corruption in Poland (twice) and the opening keynote speaker at Auscert in Australia.
Bennett has been called... 'A Welsh Seinfeld' by The Guardian, 'Genuinely Original and Funny' by The Times and 'Case Number 2477419' by The Metropolitan Police.
From the Front Lines: The Top 10 DNS Attacks
Apr 9 2015
5:00 pm
45 mins
Srikrupa Srivatsan, Sr. Product Marketing Manager, Infoblox
More than 75% of organizations in the U.S. and U.K. have experienced at least one DNS attack according to SC Magazine. DNS Attacks are increasing in frequency and evolving constantly. They range from common amplification, reflection, and flood attacks to more sophisticated and stealthier types. These might have fancy names like random subdomain, phantom domain, and domain lock-up, but their effects on DNS are far from pretty. Join this webinar as we reveal the top 10 attacks on external and internal DNS servers; and the impact they have on your operations.
Optimize Customer Signup Flows Online and in Your Mobile App
Apr 9 2015
4:00 pm
45 mins
Chris Morton, President, Block Score; Lisa Aguilar, Marketing Manager, Jumio; James Bickers, Senior Editor,Networld Medi
In today's online and mobile environment, financial service organizations are struggling to comply with a multitude of regulatory requirements that impede online and mobile customer signups. What is the best way to signup customers while still complying with regulations and mitigating fraud?
Join us for a live webinar, "Optimizing customer signup flows in your mobile and web channels" and listen in as experts in ID authentication and identity verification discuss various strategies that will help you:
· Quickly and safely signup customers through your mobile and online channels
· Remain compliant with regulatory requirements without adding additional operational overhead
· Reduce customer sign-up abandonment
Don't loose another customer because you can't offer a real-time sign-up process through your online and mobile channels. Join us and learn how to optimize your sign-up flows, and enable anytime, anywhere through any digital channel customer account opening.
Looking Forward to HIMSS 2015: What are the latest trends?
Apr 8 2015
5:00 pm
60 mins
Lysa Myers, Security Researcher III, ESET North America
ESET security researcher Lysa Myers discusses developments in healthcare IT system security that you may see at the HIMSS conference in Chicago next week. Find out what is being done to better protect patient data privacy and more.
How Mobile Data Protection Can Accelerate Top CIO Initiatives
Apr 8 2015
4:00 pm
60 mins
Seyi Verma, Sr. Product Marketing Manager
The proliferation of data on mobile devices has created huge headaches for CIOs as they attempt to protect data, stay in compliance and move workloads to the cloud. How IT approaches data protection for mobile devices can support or hinder these high level efforts. Endpoint backup, traditionally viewed as a functional requirement below the radar of CIOs, is evolving to offer not just data backup and restore, but also a modern way to address costly data governance challenges such as compliance and eDiscovery. This webcast will cover real-world case studies of Fortune 1000 companies leveraging endpoint backup solutions to gain significant business advantages including cost control, compliance and embracing the cloud.
ISA 62443 Patch Management Overview and Methods for Zero-Day Threat Protection
Apr 8 2015
4:00 pm
75 mins
Joe Weiss, Managing Director for ISA99; William Cotter, Systems Engineering Specialist; Delfin Rodillas, Sr. Manager of SCADA
The growing presence of widely known and used Commercial Off-the-Shelf (COTS) systems in Industrial Control Systems (ICS) provides an increased opportunity for cyber attacks against ICS equipment. Such attacks, if successful, could have severe impact to not only process availability but also safety. Patch management is one particular area of cybersecurity which requires special attention when applied to ICS. It is part of a comprehensive cybersecurity strategy that increases cybersecurity through the installation of patches that resolve bugs, operability, reliability, and cyber security vulnerabilities. The ISA-TR62443‑2‑3 technical report, developed by the ISA 99 Working Group 6, addresses the patch management aspect of ICS cyber security. Also part of an effective strategy is the use of compensating cybersecurity controls to protect ICS systems from exploits and malware in between often long patching cycles. Novel network and host based technologies have recently become available to address even zero-day threats which bypass conventional signature-based approaches.
Attendees of this webinar will leave with a better understanding of:
-The unique aspects of ICS that entail a different and more rigorous approach to patch management than that used in business networks
- An overview of the ISA 99 standards efforts with detail review of the main aspects of the ISA-TR62443-2-3 Technical Report on Patch Management in IACS
- Advancements in compensating cybersecurity controls for protecting systems from zero-day threats
Why DDoS Makes for Risky Business – And What You Can Do About It
Apr 8 2015
3:00 pm
60 mins
Dave Shackleford, IANS Lead Faculty and Tom Bienkowski, Director of Product Marketing
Despite years of headlines, and countless examples, many organizations are still under the impression that DDoS attacks are a problem for somebody else (i.e. their ISP), or that it's a problem that can be defended using an existing on-premise security solution, such as their firewall or IPS. In a risk obsessed world, these organizations are ignoring the very real likelihood of becoming a target for DDoS attacks, along with the severe operational and business consequences of falling victim to an attack.
It's time to debunk some misconceptions about DDoS.
Attend this webinar to learn:
- Why a single layer of DDoS protection isn't enough
- How the impact of a DDoS attack is significantly more costly than protection options
- The correlation between DDoS attacks and advanced threats revealed in our latest research and how both are used during multiple phases of an advanced threat campaign.
Your organization has been breached, now what?
Mar 31 2015
32 mins
Dal Gemmell, Director of Product Management and Steve LaBarbera, Director of Security Solutions, SentinelOne
Unfortunately, there is a high likelihood that organizations will suffer a breach by advanced malware. Learn how to minimize response time through real-time forensics to understand the scope of compromise including:
- Identifying attacked endpoints
- Finding indicators of compromise
- Analyzing malicious activity
- Tracing outbound communication, and more
UTM + USM: All you need for complete Threat Management
Mar 31 2015
48 mins
Patrick Bedwell, AlienVault; Neil Matz, Fortinet
Did you know the average breach goes undetected for 229 days? The earlier you can detect and respond to a breach, the faster you lower the risk and potential damage. Traditionally, companies have implemented a number of point solutions to for each new threat, an expensive and cumbersome approach. However, by combining threat protection from Fortinet with threat detection and response from AlienVault, companies now have an affordable way to significantly reduce the cost and complexity of complete threat management.
Join threat experts from AlienVault and Fortinet for this webcast to learn how this integrated solution will provide:
· Continuous threat prevention, detection and remediation in an easy-to-use solution
· The ability to identify all critical assets and the potential attack surfaces in your network
· Advanced analysis of FortiGate logs for threat identification and response through AlienVault USM
· Simplified protection of your network with ONLY two products, at a price you can afford
· Continual improvement of your security posture through frequent assessment.
· Integrated threat intelligence that maximizes the efficiency of your security monitoring program
The latest trends and best practice advice from the leading experts
This channel features presentations by leading experts in the field of information security. From application, computer, network and Internet security to access control management, data privacy and other hot topics, you will walk away with practical advice for your strategic and tactical information security initiatives.
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CAO Concert Roadie 5 Pack
CAO Concert cigars were inspired by the brand's Nashville roots. Medium to full in body, CAO's Rick Rodriguez has created a marvelous harmony of flavor using a combination of 4 diverse Nicaraguan & Honduran fillers with a Connecticut Broadleaf binder, and rolled them in a lustrous Ecuadorian Habano Rosado capa. The smoke starts with a kick of pepper then rounds out to a subtle sweetness. Though widths vary, each Concert vitola is 5½-inches long. Order some of these melodic masterpieces now.
Didn t know what to expect from this as Famous sent me a single with my order. Not to look a gift horse in the mouth but I m glad they did. As somewhat of a newb to the world of cigars this is easily one of the tastiest I ve smoked. Very smooth and taste of coffee hints of spice and pleasant sweetness. burned excellent even in semi-windy conditions and enjoyable on an empty stomach. Thanks Famous
Got one free with my order.Smoked it next day.Taste,draw,burn,construction,was excellent.Will try a box.
I recieved this stogie as a gift. Not sure I would have tried this on my own. This is a milk chocolate colored cigar. The ash is nearly snow white which gives it a very apealing appearance. Nice creamy smooth taste and aroma that reminded me of roasting nuts and freshly ground coffee. I'll be getting more of these.


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WUFT News
Gator herding on game day
More Stories in Sports
UF Organization To Host Barrels For Boobs Surfing Competition For Breast Cancer Charity
Wahines of the Waves is hosting Boobs for Barrels, a philanthropy event benefitting the Florida Breast Cancer Foundation. The event starts at 9 a.m. on March 28 at Butler Beach near St. Augustine.
Barr Rises As One Of Nation's Top High Jumpers
Gainesville athlete Kieme Barr is one of the top-10 high jumpers in the country. He will represent the United States in July in the Down Under 2015 Australian Tournament if he can raise enough money.
NCAA Released Infractions Report On Florida Football Program
UF will not receive any penalties because of steps the institution took once the claim was brought to its attention.
Florida Hangs On Against Vanderbilt To Earn Much Needed Win
It was another close game at home for the Gators, who managed to squeeze past Vanderbilt 50-47 on Wednesday night. This win stops the team's four game losing streak.
Gators Can't Hold On To Take Down Top Ranked Wildcats
The Florida Gators lost to the top-ranked Kentucky Wildcats on Saturday, 68-61.The Gators led by two points going into halftime, but Kentucky answered back with a strong second half, outscoring the Gators 40-31.


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WANTED: plants or leaves
pattykay_gwMay 8, 2010
I am looking for plants or leaves of the following-
Evening Shade, Canadian Sunset, Winter Parasol, Ness' Cranberry Swirl and Ness' Crinkle Blue. If you would like to do a trade email me at email@example.com. I have lots to trade with or will send postage. Pattykay


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6 items from 2015
14 March 2015 3:00 AM, PDT | Bollyspice | See recent Bollyspice news »
Prolific film-maker J. P. Dutta's daughter, Nidhi Dutta is hard at work. She is gearing up to make her debut in Bollywood and for this, Nidhi has lost a whopping 26 kilos and needless to say she looks stunning.
Nidhi will be making her debut with her father's film which will be directed by Binoy Gandhi. The actress says that shedding the pounds was not easy for her but she decided to take up the challenge after her father called her 'very fat' for the role. It took the help of trainer Yasmin Karachiwala, six months and a strict diet of salads to reach this weight. But Nidhi says she still has six more kilos to lose before she reaches her ideal weight. Her incentive is not only the lead role but also because she will be shooting a promotional song for the movie that requires her to be very fit. »
- Press Releases
4 March 2015 4:08 AM, PST | Entertainment Tonight | See recent Entertainment Tonight news »
Spanish actress Anna Allen takes the phrase "fake it till you make it" to a new level.
Numerous news outlets are claiming the 32-year-old performer has been photoshopping her face on celebrities' bodies and reposting their pics on her Instagram as if they were her own. As of late, the Anna Allen Instagram account is not in service.
The actress' alleged web of lies was discovered when she started sharing pics from the Oscars.
Photos: Before and After -- Stars' Most Dramatic Transformations
According to formulaTV, Anna cropped Lupita Nyong'o's 2014 invitation to the Academy Awards and posted as her own on Instagram -- though failed to crop out the year. "So it's official," the caption reads, purportedly from Anna's account. "I'm invited to the Oscars!"
But her alter ego doesn't stop there. The actress also photoshopped her head on several celebrities, including Keira Knightley. She also, according to reports, photoshopped herself »
5 February 2015 3:42 AM, PST | Us Weekly | See recent Us Weekly news »
Class is back in session! The gang from Saved by the Bell's Bayside High School came together once again for an amazing, nostalgia-filled reunion skit during The Tonight Show With Jimmy Fallon on Wednesday, Feb. 4. The former costars shared behind-the-scenes photos and seemed just as "excited!" as ever to don their mom jeans, cheerleading uniform, and more. Mirror mirror... Tonight on @jimmyfallon pic.twitter.com/frY910p1fo — Mark-Paul Gosselaar (@Mpg) February 5, 2015 Before and after the big reveal, series stars Mark-Paul Gosselaar (Zack Morris), Tiffani Thiessen (Kelly Kapowski), Elizabeth Berkley [...] »
22 January 2015 5:57 PM, PST | Entertainment Tonight | See recent Entertainment Tonight news »
It's kind of unfortunate that rappers Iggy Azalea and Azealia Banks don't like each other because, let's be honest, this was bound to happen at some point.
News: Azealia Banks Slams Iggy Azalea on Twitter, Calls Her 'Igloo Australia'
On Tuesday's episode of Jeopardy!, contestant Nicholas Berube buzzed in to provide the corresponding question to this answer: "This Australian hip-hopper used the pet name/street name system to come up with her rap name."
Berube, unfortunately, responded "Who is Azealia Banks?" when the answer was actually referring to Aussie rapper Iggy Azalea. The mix-up is even more ironic due to the stars' ongoing feud.
The answer quickly went viral, and Berube even took to Twitter to apologize for his mixup.
Hey @Azealiabanks - I'm the guy on Jeopardy who mixed you up with Iggy Azalea. I apologize. I actually think you're awesome.
— Nicholas Berube (@nicholas_berube) January 21, 2015
To be fair, "Iggy Azalea »
22 January 2015 4:14 AM, PST | Variety - TV News | See recent Variety - TV News news »
In a rare move one of China's censors has gone on the record to explain why popular TV drama "The Empress of China" was ordered off air for a re-edit.
Tian Jin, deputy director of the State Administration of Press, Publication, Radio, Film and Television, said Wednesday that the show contained "unhealthy images."
The period drama starring Fan Bingbing as the country's only known empress, Wu Zetian, ran on satellite channel Hunan TV from Dec. 21 before it was taken off. When it reappeared on Jan. 1 many full-length and mid-length shots had been closely cropped to become headshots, eliminating the cleavage-revealing dresses that were the fashion of Wu's era.
The re-edit provoked howls of criticism online that the industry regulators are absurdly over-protective. Before and after shots revealed that many of Fan's multiple costume changes were rendered invisible.
It also sparked renewed calls for a rating system »
- Patrick Frater
21 January 2015 6:15 AM, PST | PEOPLE.com | See recent PEOPLE.com news »
We've teamed up with one of our favorite sites, BarkPost, to bring you and your four-legged friends even more adorable pet videos, photos and must-see stories. Check back every week for new furry fun from BarkPost!When Hope For Paws Animal Rescue received a call notifying them of a stray pup wandering around a local neighborhood, the rescuers decided to film the pick-up. What they found was a soiled, clumpy little mutt who was obviously wary of strangers. But a few treats later, the dog becomes a big-eyed baby, cradled in the welcoming arms of a human who cared enough to help. »
- BarkPost
6 items from 2015
IMDb.com, Inc. takes no responsibility for the content or accuracy of the above news articles, Tweets, or blog posts. This content is published for the entertainment of our users only. The news articles, Tweets, and blog posts do not represent IMDb's opinions nor can we guarantee that the reporting therein is completely factual. Please visit the source responsible for the item in question to report any concerns you may have regarding content or accuracy.See our NewsDesk partners


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Learn more about Water Slide with Playstation Bounce House:
Manufacturer: Bounceland
Mfg Part#: 9253
Sku: 220602139
Package Weight: 66 lbs
Batteries: Not Applicable
See more in Inflatable Bouncers
|BXV1011: Features: -Includes basketball hoop, wet or dry slide, ball pit with 30 plastic balls, tunnel, hoop shooting, ground stakes pack, large carrying bag, repair kit and instructions. -14 - 16 oz. heavy-duty, laminated and coated vinyl and nylon. -Heavy-duty puncture proof materials with double to quadruple stitches. -Materials comply with ASTM (American Society for Testing and Materials) toy safety standards. Finish: -Red,Blue,Yellow,Green. Dimensions: Overall Height - Top to Bottom: -102 Inches. Overall Width - Side to Side: -108 Inches. Overall Depth - Front to Back: -210 Inches. Overall Product Weight: -64 Pounds.


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Very quiet. Reasonable price and value. Staff was very accommodating, but not fluent in English - Anonymous
Really nice hostel. We stayed in a double room with a shared bathroom. We had a massive room with a double bed and a single bed and windows on two sides. We never had to queue for the bathroom which was kept really clean. The communal kitchen is also extremely clean and is probably the best we have had in 7 months in South America. The wifi was good (including for streaming). The staff were friendly and helpful (including getting a massive beetle out of the shower for me). No mosquitos in Tena! - Anonymous
We are digital nomads and planned to stay for one night at the CasaBlanca. We ended up staying for 8 days when we discovered that they had:
1) a brand new hotel (built last year and opened in Jan. 2013) with discounted weekly and monthly rates.
2) good Wifi
3) a laundry room with full size washer and dryer (for free!)
4) safe water straight from the tap due to a UV light and filter system they installed when building the house (!!). You can drink the water in the shower... crazy!
5) an amazin - Anonymous


text: Search results Listings are for East Coast. For local listings, Enter zip code or Sign in Go Display: All Results TV Shows Movies Actors Directors Only show HD Only show new episodes We found the following shows with actor/director: "Alan Taylor" in the next 14 days. Sex and the City Next episode: The Sex Buddy Wed 4/1 3:30 PM 10 E (Cbl) 30 minutes TV-14 Carrie's date is unsuitable; the couple next door arouses Samantha; Charlotte double-books dates; Miranda dates a nasty man. View in TV Listings 1-Click Record 1-Click Season Pass Record with options Thor: The Dark World (2013) Fri 4/3 3:00 PM 159 STARZ (Cbl) 2 hours PG13 Thor forms an alliance with treacherous Loki to save Earth and the Nine Realms from an ancient enemy that predates the universe itself. View in TV Listings 1-Click Record Record with options


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Do People Get AIDS From Biting
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
Frequent bite by dog between HIV & non HIV personsHello, i read you response about another instance where a dog bit an infected person and then a non infected person. However, I am pretty sure the time gap between our bites was less. My main question is, how long before if I am infected will it...
Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS Foundation...Hi,HIV is not transmitted via dog bites, even if the dog is Cujo and he bites multiple folks one right after the other. Neither worry Read more »
HIV INFECTED PERSON BODY REACTION TO MOSQUITO BITEHIPLZ EASE MY MIND COZ I M ON THE VERGE OF RUNNING AWAY FROM HOME FROM FEAR OF BEIN POSITIVE.I AM... Read more »
I'm HIV+ and an infant bit my face, risky for the infant? (HUMAN BITE, 2010)Hello Dr. Bob,Although I am well educated on HIV risk and transmission, a recent incident has me... Read more »
Michigan Lawmakers Decry Case Charging HIV-Positive Man With Terrorism for Biting...A neighborhood tussle in October became an issue of terror when an HIV-positive man was charged with attempted bioterrorism for allegedly biting his neighbor while the two were fighting one another, Read more »
AIDS Advocates Stage Protest Following Death of HIV-Positive Man Sentenced to 25 Years for Biting Prison Guard...Camden County Jail and that the biting charges stemmed from "AIDS hysteria," according to the Inquirer . Dan Murphy, a spokesperson for ACT UP/Philadelphia, said that the demonstrators on Thursday were also demanding better medical care for... Read more »
AIDS Myths and Misunderstandings... Why Are There so Many AIDS Myths? Myths About "Catching" HIV Myths About a Cure AIDS Is a Death Sentence The Government Developed AIDS to Reduce Minority Populations Myths About Read more »
One-Quarter of Canadians Believe HIV Can Be Transmitted Through Kissing, Mosquito Bites, Poll Says...Approximately one in four Canadians believes HIV/AIDS can be transmitted through kissing and mosquito bites, indicating a "knowledge gap" in the general public regarding the Read more »
Connect With Others
Bite the Bullet
Posted by Nailbiting, 2 Replies...but I know that doesn't matter. But why start feeling so bad 15 weeks or so after the incident if it is something to do with HIV. I guess I need to bite the bullet and just get tested but man I am scared and part of me doesn't want to know but I... Read more »
Love Bites and HIV
Posted by Anonymous, 1 Reply...Can sucking on skin to produce Love Bites transmit HIV? Can the skin break by merely sucking hard on them? Read more »
Biting and HIV
Posted by Anonymous, 2 Replies...Ok... I know the sensible thing to do if you have any concerns about HIV is to get tested but I am not sure if I am over reacting or if I have cause for concern... I was kissing a guy whos HIV status Read more »
Human Bite and HIV
Posted by Anonymous, 1 Reply...no break in my skin, rather I have a bruise. She also said that if the skin is intact, there is no risk of getting any STD or HIV from getting bitten. The "bruise" went away in 2 days. But 2 weeks after the incident, on my follow up visit to my... Read more »
Resource Centers
Guides for People With HIV


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Alkaline earth metals Reference Libraries
Page 1 of about 1 Articles
2005-05-26 12:07:27
Beryllium is the chemical element in the periodic table that has the symbol Be and atomic number 4. A toxic bivalent element, beryllium is a steel grey, strong, light-weight yet brittle, alkaline earth metal, that is primarily used as a hardening agent in alloys (most notably, beryllium copper). Notable characteristics Beryllium has one of the highest melting points of the light metals....
Word of the Day
- Forsooth! indeed! originally a parenthetical phrase used in repeating the words of another with more or less contempt or disdain.
The word 'quotha' is an alteration of 'quoth he'.


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Today: Join HRC for a Panel on LGBTI Refugees in Uganda and Kenya
May 17, 2012 by HRC staff
Post submitted by Eric Cameron, HRC Digital Media Specialist
This afternoon, HRC proudly presents the release of The Road to Safety: Strengthening Protection of LGBTI Refugees in Uganda and Kenya by Human Rights First to commemorate International Day Against Homophobia and Transphobia.
This is the second event in HRC's Equality Talks speaker series. We hope you can join us today at 3:30 p.m. EST, here in HRC's DC headquarters or live online.
The event will feature remarks from special guests, including the Honorable Anne Richard, Assistant Secretary of State for Population, Refugees and Migration. The panel that follows will feature distinguished guests from Human Rights First, the UN Refugee Agency and the Council for Global Equality.
A full list of speakers and details about the location are available here. HRC is thrilled to help bring together such an impressive line-up of refugee advocates and experts. If you can't make the talk, a live broadcast will be available at www.hrc.org/equalitytalks. Video will remain available in the weeks to come.
Top Posts
HRC Arkansas to Governor Asa Hutchinson: Veto SB202 Now
February 18, 2015
HRC's Time to Thrive Conference Kicks Off in Portland, Oregon
February 14, 2015
Epidemic of Anti-LGBT Violence Continues with Murder of Ohio Youth
February 16, 2015
"Love Has No Labels" Ad Campaign Celebrates Diversity and Inclusion
February 18, 2015


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avondje filmen in het vernieuwde park
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text: Record 8 tons of trash cleared from Everest Money Money Science Living Food & Travel Asia News Desk on Dec 31, 1969 @ 7:33 PM This picture taken on May 23, 2010 shows a Nepalese sherpa collecting garbage, left by climbers, at an altitude of 8,000 meters during the Everest clean-up expedition at Mount Everest. A group of 20 Nepalese climbers, including some top summiteers collected 1,800 kilograms of garbage in a high-risk expedition to clean up the world's highest peak. The largest ever amount of trash was removed from Mount Everest this week, with more than 8 tons of garbage brought down by yak and porter from the world's highest mountain peak. A team of 29 Nepali mountaineers spent six weeks clearing trash from Everest in an annual clean-up campaign, Deutsche Presse-Agentur reports, citing local media. The team removed oxygen cylinders, tents, ropes, cardboard, climbing equipment and helicopter parts from the mountain. "Nineteen of us worked above the Everest Base Camp for seven hours or more to bring down waste every day," said Pasang Sherpa, the team leader, DPA reports. "Each one of us carried down a minimum of 30 kilograms of waste." After collecting the garbage at base camp, 75 yaks and 65 porters transported it to Namche Bazaar, a village that is considered the gateway to the Everest region in Nepal. The clean up, which continued through April and May, had been delayed by bad weather and fresh snow that covered up the garbage, The Associated Press reports. Yearly clean ups of Everest began in 2008, but experts say another 50 tons of waste remains on the mountain slopes. Since it was first conquered in 1953, more than 5,000 people have climbed Everest, discarding climbing equipment, including empty oxygen bottles and ropes, along the way. While Nepal now requires climbers to bring down everything they carry up the mountain, Everest is still littered with debris from past climbs, the AP reports. There are also dozens of bodies of climbers left on the summit, in the so-called "Death Zone." Since 1953, 250 people have died while climbing Everest, DPA reports.


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A project of People For the American Way dedicated to monitoring and exposing the activities of the right-wing movement. Learn More >
Perkins: Americans Will Never Accept Gay Marriage Because it 'Violates Reason and Natural Law'
Recently, Tony Perkins and Harry Jackson sat down for a half-hour interview with CBN's David Brody to discuss President Obama's support for marriage equality and what it will mean for the 2012 election.
Brody has posted the entire interview on his blog, in which Perkins compared the issue of gay marriage to the issue of abortion, declaring that Americans will never accept the legitimacy of gay marriage, regardless of what the courts rule, because "same-sex marriage violates reason and natural law" and warning that any Supreme Court ruling upholding the legality of gay marriage will "create great unrest in this society":
For his part, Jackson saw the President's statement as an opportunity to create a new "Black-Brown coalition" among African Americans and Hispanics rooted in opposition to the Democratic Party's growing support for gay rights and fueled by resentment against gay activists who are trying to push minorities to the back of the line.
Jackson said comparisons between the push for gay rights and the struggle for civil rights are nonsense because systematic discrimination and violence against the gay community "never happened" and warned that if African Americans and Hispanics don't escape the "Democratic Party plantation," then "America's best days are over":
Filed Under
Organizations:Family Research Council
People:David Brody , Harry Jackson , Tony Perkins
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Senior Member
what are yall using? my first custom i rolled with pretty much the exact same as the spotlight but i used move speed quints. is the health regen really worth it?
Sardis Jett
Probably since everyone is *****ing about how he can't lane sustain
so basically it's a decision between health regen quints or a health regen first item?
Or both?
I'm going Armor Pen Reds, Armor Pen Quints, Armor Yellows and MR Blues. Probably an awful rune set but I've won 3 in a row.
So it must work at little.
I use armor pen quints and marks, armor yellows and MR blue
Ok so based upon the meta...aka support/ad carry bot, ap carry mid, tanky dps top, and tanky/ap jungler, Monkey King fits the tanky dps top role.
Phreak probably is using HP5 quints to give him some lane sustainability in top solo because he is likely to be facing champions like Irelia and Yorick who have lifesteal/healing abilities.
One different route could be to use Move speed quints (if you like those) and take a Regrowth Pendant + Health Potion to go for a Philo Stone later. That would give you serious sustainability while also giving you the move speed that you like (and getting you that GP5 item sooner ^^). The only downside is that you can't run a Doran's item early or something like that to help with last hitting.
Hope this helps.
© 2015 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


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Bidirectional map
From Wikipedia, the free encyclopedia
|This article needs attention from an expert on the subject. The specific problem is: "Ambiguous definition". (December 2012)
In computer science, a bidirectional map, or hash bag, is an associative data structure in which the pairs form a one-to-one correspondence. Thus the binary relation is functional in each direction: can also act as a key to . A pair thus provides a unique coupling between and so that can be found when is used as a key and can be found when is used as a key.
External links[edit]
- http://www.boost.org/doc/libs/1_47_0/libs/bimap/doc/html/index.html
- https://commons.apache.org/proper/commons-collections/javadocs/api-release/org/apache/commons/collections4/BidiMap.html
- http://cablemodem.fibertel.com.ar/mcape/oss/projects/mc_projects/boost_projects/boost_bimap.html#
- http://www.codeproject.com/KB/stl/bimap.aspx
- http://guava-libraries.googlecode.com/svn/tags/release09/javadoc/com/google/common/collect/BiMap.html
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Risk Management
Find out about how risk management and legal liability issues can affect real estate professionals.
The majority of home owners know about flood insurance, yet few actually add the extra coverage to their standard homeowner's insurance policy.
A home inspector reveals what home sellers should do before a home inspection.
Topics: Working with Sellers, Risk Management
A new study suggests that home owners may be unaware of unhealthy conditions in their homes.
The FHA has taken a number of significant steps to mitigate risk and increase the solvency and strength of the mortgage-insurance fund.
Topics: FHA, Risk Management
A hazardous materials team was dispatched after a real estate agent removed 40 gallons of toxic chemicals from a Novato, Calif., home for sale.
This field guide provides articles, studies, websites, and other resources provide information on all aspects of lead-based paint for REALTORS® and property managers, including disclosure issues, impacts on the industry, and lead poisoning prevention.
Topics: Risk Management, Lead-Based Paint
Following a security breach, a popular online note-taking service used by many real estate professionals reset all 50 million of its users' passwords.
Topics: Risk Management, Data Privacy and Security
Sinkholes are a lot more common than many home owners realize—particularly in Florida, according to CoreLogic.
Minnesota state health officials are proposing that home buyers get greater warnings about indoor levels of radon, a deadly gas.
There are no federal rules that require sellers to disclose whether a home was once used as a meth lab. So what should your buyers do if they suspect the poisonous substance?
Topics: Risk Management, Working with Buyers


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An improved implantable pharmaceutical depot for the prolonged release of at least one biologically active substance, the depot comprising a polymeric carrier and the biologically active substance, the improvement wherein the depot is coated or surface modified with a biologically active and biocompatible glass, glass-ceramic or ceramic material, the coating or modified surface being capable of forming a bond to soft tissue upon implantation. Methods for forming the biologically active and biocompatible glass, glass-ceramic or ceramic coating or modified surface on the silicone based depot are also disclosed.
1. An improved pharmaceutical depot adapted for implantation in a human or non-human animal for the prolonged release therewithin of at least one biologically active substance, said depot comprising a silicone carrier and incorporated therein said biologically active substance, the improvement wherein said depot is coated with a biologically active and biocompatible glass, glass-ceramic or ceramic material comprising at least about 40 weight percent silicon dioxide, said glass coating being capable of forming a bond to soft tissue upon implantation.
2. The depot of claim 1 wherein said biologically active and biocompatible glass, glass-ceramic or ceramic has the following weight percentage composition:
3. The depot of claim 1 wherein said coating of said biologically active and biocompatible glass, glass-ceramic or ceramic has a thickness of from about 0.02 mm to about 1.0 mm.
4. The depot of claim 1 wherein said biologically active substance is a steroid, hormone, antibiotic, chemotherapeutical agent, prostaglandin, vitamin, contraceptive or behavior modification agent.
1. Related Application
Reference is hereby made to provisional patent application Ser. No. 60/105,982 filed Oct. 28, 1998, upon which the claim of domestic priority is based herein.
2. Field of the Invention
The present invention relates to drug depot or delivery systems.
3. Description of the Prior Art
The introduction of pharmaceutical agents and the like into a specific site within the body of a patient over a requisite time period by injection or infusion has been proven to be impractical. The predictable, controlled delivery of selected molecules into specific sites in the body is, therefore, preferably accomplished by injection or incorporation of the molecules into a �drug delivery system� or �drug depot� which is implanted into that site. Materials previously proposed to release therapeutic agents into bone tissue, for example, include a variety of resorbable and non-resorbable polymers including polylactic acid and polymethylmethacrylate, and synthetic calcium phosphates including the mineral hydroxyapatite and the compound tricalcium phosphate.
One of the more widely used materials for the construction of such depots are the silicone rubbers, e.g., Norplant� marketed by Wyeth-Ayerst. Drug depots constructed of silicone rubbers suffer, however, from the disadvantage that fibrous scar tissue capsules tend to form around the devices following implantation. This scar capsule is not well vascularized and hinders both the release and availability of the drug from the system. Drug levels have been shown to be reduced by as much as 75% after 21 days implantation [Munro et al, Contraception, Vol. 54, pages 43-53 (1996)].
The lack of biocompatibility of implantable materials has been described as being the main problem in the development of long-term drug delivery systems [Park et al, Pharmaceutical Res., Vol. 13, pages 1 770-1776 (1996)]. Current devices consist of silicone tubes filled with the desired drug or agent. When these are implanted, the drug slowly diffuses through the silicone and into the surrounding tissue. The above-noted decreased availability of drug due to incompatibility of the carrier system has a high degree of variation among individuals, thus requiring a large initial drug loading and making the calculation of required drug loading a difficult problem to overcome. Improved availability of the drug to the surrounding tissue would improve the reliability of these devices and could reduce the amount of the drug needed for sustained therapeutic delivery, thereby increasing the performance of the device, reducing the possible side effects of variable drug levels released from the implant, and reducing the cost and size associated with the device.
Despite these complications, many types of drugs have been delivered using silicone depots. The following table sets forth a representative number of examples of drugs having a variety of therapeutic effects that have been incorporated heretofore in silicone depots.
It is an object of the present invention to provide improved silicone rubber drug depot systems which are not subject to the above-noted disadvantages.
The above and other objects are realized by the present invention, one embodiment of which relates to an improved implantable pharmaceutical depot for the prolonged release of at least one biologically active substance, the depot comprising a carrier constructed of materials such as silicone and the biologically active substance, the improvement wherein the depot is coated with or surface modified by a biologically active material such as a biocompatible glass, glass-ceramic or ceramic material, the coating or modified surface being capable of forming a bond to soft tissue upon implantation.
Another embodiment of the invention relates to methods for forming the coating or surface modification comprising the biologically active and biocompatible glass, glass-ceramic or ceramic on the silicone based depot.
One method of forming the improved depot is to form a coating of the silicone or other suitable polymer and bioactive glass, glass-ceramic or ceramic on the biologically active substance containing depot. Another suitable method comprises incorporating the bioactive glass, glass-ceramic or ceramic in the silicone or other suitable polymer of construction during formation of the depot itself and then removing sufficient silicone (or other polymer) from the surface of the depot system to expose particles of the bioactive glass, glass-ceramic or ceramic thereon.
FIG. 1 is an FTIR spectra of a 45s5 Bioglass� implant after 0, 1 and 2 hours in TBS at 37� C. [Hench, J. Am. Ceram. Soc., Vol. 74, pages 1487-1510 (1991)].
FIG. 2 is an FTIR spectra of Bioglass�-coated silicone samples. From the top, the samples are uncoated silicone reacted for 20 hours in SBF at 37� C., silicone coated with 0.5 g Bioglass� per 25 cm2 of silicone unreacted, and silicone coated with 0.5 g Bioglass� per 25 cm2 of silicone reacted for 20 hours in SBF at 37� C. The formation of an hydroxyapatite layer can be seen in the bottom spectrum (see double peak at 600 cm−1).
FIG. 3 depicts a surface analysis using low voltage SEM and shows hydroxyapatite crystals on both Bioglass� particles (top right) and on silicone between particles (middle) when reacted for 10 days in SBF at 37� C. Bioglass� powder used was 45s5 in the 710-900 micron size range.
FIG. 4 depicts a surface analysis using low voltage SEM and shows hydroxyapatite (HA) crystals on silicone coated with Bioglass�. Concentration of HA crystals is greatest next to Bioglass� particles (top left). Samples reacted for 10 days in SBF at 37� C.
It has unexpectedly been found that the biologically active and biocompatible glass, glass-ceramic and ceramic (hereinafter referred to as �bioactive glass�) bonds directly to surrounding soft tissue following implantation, thereby inhibiting or preventing the formation of the fibrous scar tissue capsule normally associated with the implantation of silicone materials. The presence of healthy tissue surrounding the depot improves the bioavailability of the contained biologically active substance to the vascular system. Most unexpectedly, it has been found that the bioactive glass coating does not impede diffusion of biologically active substance molecules out of the silicone system and into the subject patient's system.
Any of the polymeric materials utilized for the construction of implantable devices may be used in the practice of the invention. Exemplary of silicone materials are those used in Norplant� (Wyeth-Ayerst), Uniplant� (South to South Corp.), Silgel� (Wacker Chemie GmbH), and the like. Generally, the silicone implantable depots are constructed of polydimethylsilicone (PDMS). A typical such material is dimethylpolysiloxane (Silgel� 601, Wacker Chemie GmbH), an addition cross-linking two-component composition of nine pats of component A and one part of component B. Dimethyldiphenylpolysiloxane, dimethylpolysiloxanol or silicone copolymers may also be employed.
It will be understood, however, by those skilled in the art that the device may also be constructed of any other suitable polymeric material therefor which is compatible with bioactive glasses, glass-ceramics or ceramics. Exemplary of such other polymeric materials are the porous, ethylene/vinyl acetate copolymers which have been utilized to construct depots for the implantable release of hydrophilic biologically active substances such as proteins through the pores thereof.
It will also be understood that any biologically active substance compatible with the silicone carrier may be utilized in the practice of the invention. Exemplary of suitable substances are steroids, hormones, antibiotics, chemotherapeutical agents, prostaglandins, vitamins, contraceptives, behavior modification agents, and the like.
Those skilled in the art are aware of conventional methods for the formation of silicone/active substance depot systems and any such methods may be used to prepare the devices suitable for coating or modification with bioactive material according to the invention. The artisan is also aware of the amounts of active substances to be included in the depot devices, as well as the parameters of construction and methods for their implantation in suitable hosts.
The bioactive material used to coat the silicone depot devices of the invention may comprise any of the known materials, as well as those yet to be discovered which form a bond to soft tissue upon implantation. Exemplary of such bioactive materials are those described in U.S. Pat. Nos. 4,171,544; 4,234,972; 4,775,646; 4,851,046; 5,074,916 and 5,728,753, the entire contents and disclosures of which are incorporated herein in their entirety by reference thereto. Typical of suitable bioactive glasses are those having the following weight percentage composition:
The coating or layer of bioactive material on the depot device may be any desired thickness, generally in the range of from about 20 microns to several millimeters and, preferably, from about 0.02 mm to about 1.0 mm.
In the following non-limiting examples, the invention is illustrated employing silicone as the polymeric material. Generally, silicone medical devices are constructed employing two-component liquid silicone precursor systems which are commercially available. Upon mixing and subsequent sequent thermal treatment, the two-component system cures into the solid silicone material having any desired shape or configuration.
The bioactive glass, glass-ceramic or ceramic, in particulate or fiber form, is preferably admixed with the two- component liquid silicone precursor system and applied as a coating on the depot device (which, in this case, is also preferably constructed of silicone; preferably, the same silicone). Upon curing, a hardened, solid surface coating of the bioactive material/silicone is formed on the depot device.
Alternatively, the depot device may be coated with the liquid two-component silicone precursor system and then the particles or fibers of bioactive glass, glass-ceramic or ceramic applied thereover. Upon thermal curing, the bioactive fibers or particles are embedded on the surface of the cured silicone coating.
Another method involves incorporating the bioactive material in the silicone system utilized to mold the depot device. Upon curing, sufficient silicone is abraded or dissolved away from the surface of the depot to expose the particles or fibers of bioactive material on the surface thereof.
A fully cured sheet of silicone (1-2 mm thick) is first made using a two-part silicone mix (dimethylpolysiloxane) and the recommended curing procedure (150� C. for 24 hours under vacuum). A solution of uncured silicone in a compatible solvent is made (5-20%) by mixing the two silicone parts with hexane solvent (suitable solvents include short chain alkanes, cyclic alkanes and chlorinated solvents, e.g., hexane, pentane, octane, chloroform, methylene chloride, trichloromethane). This solution is then either sprayed or poured onto the surface of the cured silicone sheet. The solvent is allowed to evaporate, leaving an uncured silicone layer that is 20 to 40 μm (0.02 to 0.04 mm) thick. Bioglass� 45s5 powder is then applied to the uncured surface. This coated silicone sheet is then placed in an oven at 150� C. for 24 hours to cure the silicone on the surface. The resulting material has the bulk properties of a silicone elastomer. Bioglass� particles are attached to and protruding from the surface. This surface has been shown to produce a hydroxyapatite crystalline layer on both the Bioglass� particle and the silicone surface between particles, when placed in simulated body fluid (SBF) at 37� C. for a period of 10 days.
The formation of a hydroxy carbonate apatite (HCA) layer at the surface of a bioactive glass is essential for bonding to bone or soft tissue. It is assumed that this HCA layer would prevent the formation of a fibrous capsule around the implant. Fourier Transform Infrared (FTIR) spectroscopy can be used to monitor the formation of HCA on the surface of the bioactive glass. Characteristic FTIR spectra of 45s5 Bioglass� reacted in SBF at 37� C. are shown in FIG. 1.
To evaluate the bioactivity of coated samples produced using this technique, in vitro testing of each sample was conducted in a solution of SBF at 37� C. for 20 hours and 10 minutes.
The FTIR spectra of Bioglass� coated silicone samples at each time period was measured using a diffuse reflectance stage. Comparison of the Si-O stretch, P-O stretch and P-O bend peaks confirmed the formation of a crystalline HCA layer on the surface of the coated silicone samples (FIG. 2). Surface analysis using low voltage SEM (2 kV) showed HCA particles on both the Bioglass� particles and on the silicone between the particles (FIGS. 3 and 4). This indicates the bioactivity of both the particle and the silicone surface.
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Book your room at Holiday Inn Express Hotel & Suites Jacksonville - South
Room, 1 King Bed, Non SmokingMax Occupancy: 2 guests (up to 1 child)
Room, 2 Double Beds, Non SmokingMax Occupancy: 4 guests (up to 3 children)
Room, 1 King Bed, Accessible, Non SmokingMax Occupancy: 2 guests (up to 1 child)
Standard RoomMax Occupancy: 2 guests (up to 1 child)
Suite, 1 King Bed, Non SmokingMax Occupancy: 4 guests (up to 3 children)
Hotel with a seasonal outdoor pool, in Jacksonville (Southeast Jacksonville)
This hotel is located in Jacksonville (Southeast Jacksonville), close to Saint Luke's Hospital, Dog Wood Park of Jacksonville, and Wurn Park. Local attractions also include Memorial Hospital Jacksonville and Hands on Children's Museum.
Hotel Features
Recreational amenities at Holiday Inn Express Hotel & Suites Jacksonville - South include a fitness center and a seasonal outdoor pool. Other amenities include complimentary wireless Internet access and complimentary high-speed (wired) Internet access.
Room Amenities
Televisions come with premium satellite channels. Guestrooms also feature complimentary wireless Internet access, complimentary high-speed (wired) Internet access, and refrigerators.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Holiday Inn Express Hotel & Suites Jacksonville - South features a fitness center and a seasonal outdoor pool. Public areas are equipped with complimentary high-speed wired and wireless Internet access. This hotel offers access to a business center and a meeting room. Guests can enjoy a complimentary breakfast. Event facilities measure 825 square feet (74 square meters). This Jacksonville hotel also offers multilingual staff, laundry facilities, and dry cleaning/laundry services. Onsite self parking is complimentary.
- Number of buildings/towers - 1
- Free WiFi
- Free wired high-speed Internet
- Conference space size (feet) - 825
- Conference space size (meters) - 74
- One meeting room
- 24-hour front desk
- Business center
- Outdoor seasonal pool
- Number of floors - 4
- Free breakfast
- Dry cleaning/laundry service
- Fitness facilities
- Laundry facilities
- Multilingual staff
- Total number of rooms - 88
- Safe-deposit box at front desk
- Free self parking
- Use of nearby fitness center (discount)
Available in all rooms: Free WiFi , Free wired high-speed Internet
Available in some public areas: Free WiFi , Free wired high-speed Internet
Free self parking
Room Amenities
- Rollaway/extra beds available
- Free WiFi
- Free wired high-speed Internet
- Connecting/adjoining rooms available
- Free cribs/infant beds
- Air conditioning
- Satellite TV service
- Coffee/tea maker
- Free newspaper
- Desk
- Free local calls
- Hair dryer
- Daily housekeeping
- Iron/ironing board
- Microwave
- Premium TV channels
- Private bathroom
- Refrigerator
Where to Eat
Guests are offered a complimentary buffet breakfast.
Nearby Things to Do
Recreational amenities at the hotel include a fitness center and a seasonal outdoor pool.
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible path of travel
- Accessible bathroom
- Roll-in shower
- Accessible parking
- In-room accessibility
- Accessibility equipment for the deaf
- Braille or raised signage
Hotel Policies
Check-in time starts at 3 PM
Check-out time is 11 AM
Payment types
Pets allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Rollaway bed fee: USD 10 per night
We should mention
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


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Buick Repair in Boca Raton
We found 40 Buick service shops and mechanics in Boca Raton.
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- http://d2ob0iztsaxy5v.cloudfront.net/product/320309/3203096150_exlg.jpg
Are these in my local store?CHECK STOCK
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Fun fact. The "tusk" portruding from their heads is actually a single canine tooth that extends from the mouth that is also jammed packed with nerve endings.
Anything involving Black Panther or Spider-Man.EDIT: On second thought, I think it will just be Black-Panther related, because of Klaw's relevance in the film and Captain America's broken shield.
@okayalright_44: Thanks.
@okayalright_44: Panther doesn't have TK shields. He does possess some level of telepathic resistance, but that's it.
Arguing who wins in a four-way battle is like putting together puzzle pieces that don't fit.
@makhai said:I said no because women shouldn't be allowed to read, much less write.LOL
Batman. If it was straight hand-to-hand, it would be difficult, but Batman has his gadgets available.
@kgb725 said:@static_shock: Why is thatHer life span is enhanced, so she can live to be 150. You don't have the same luxury.
@i_like_swords: @laflux: Hmmm... Well, I don't see how Panther can win this.
@sog7dc said:OP mentions no prenup. So I marry her and then divorce her and take 50 mil.Also, LOL at 100 mil not being a lot of money.This.
@kgb725 said:Yea wait for her to die get all the moneyLOL. You'll be dead decades before she dies.
She has to be physically attractive and have a good personality (which is usually the deciding factor as to whether or not I'll stay around). It can't be one or the other with me. People say looks are...
@laflux said:@static_shock: Well, that was a special case, I don't think Anakin could reliably dogde panther's blows subconciously. But I think he will be able to sense him with the force and react ...
@laflux said: Not that I can remember, but Force powers give you pre-cog and clairvoyance. Its one of the reasons why Jedi can deflect Hypersonic Blasters, aside from the fact that have enhanced Speed...
Question. Has Anakin ever fought someone that could turn invisible or teleport? How would his Force powers deal with that?
Their most recent Death Battle. Chuck Norris vs. Segata Sanshiro.
@jugjugbanks said:Sarkeesian talking about comics is like Flava Flav discussing African Politics. Or Rush Limbaugh talking about getting rock hard abs.This.
@newecho said:@static_shock: I guess that is true,, but I was under the assumption that he got every power of the mutants trapped... He didn't have to use those against wolverine though as he used hi...
@sacredweapons: "Wade skeleton was also laced with admantium."How do you know? Only thing that was (arguably) adamantium were the blades. Like I said, if he had all of his powers, he would have the bo...


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Based on 24 reviews
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I thought my representation by this lawyer was average at best. I saw no evidence of any real advocacy on my behalf. She worked out a deal quickly and told me it was the best option. I was under the impression lawyers fought for their clients particularly when there isn't a shred of evidence against them. For the money I spent I am guessing an hour and two court appearances that lasted 5 minutes each were all the time that were put in to my case.
I must admit when I first contacted this law firm I was skeptical. I was issued a speeding ticket by a WSP Trooper for speeding. After receiving the ticket I felt that the trooper was unfair and just made up the infraction. I contacted Horwath law firm who claimed to be specialized in traffic tickets, I was charged the face value of the ticket and was told not to worry that they would go to court for me. To my surprise I recieved a call from Ms. Kintanar with good news! That the ticket was dismissed completly! I am extremely happy with the outcome! I will keep them in my speed dial!
Claire and Angela Horwath's Office did a great job on my case, getting a diversion done and putting my mind at ease. I was very nervous when everything happened but they put my mind at ease, made me feel like I wasn't the worst person in the world, and Claire successfully defended me in court. Would use her and this Firm again if I needed too.
I was really grateful to have had Claire as my lawyer. She was very professional and kept me informed through out the legal process. She immediately put my mind at ease by answering all my questions and letting me know that everything will be okay. I just had to do my part and she handled the rest. I was realy thankful for the final results.
First off, I had two separate DV charges and one interfering with reporting DV. The first case Clair was able to have dismissed before we even went to trial. Months later, in another incident, she was able to do the same. Before we even went to court both charges were dropped. There were a few times I had to call and request information regarding the status of the case but you have to realize, you're not the only client. Be patient. While in court I was completely comfortable with Clair representing me. She had complete confidence in herself, and the case. The only negative comment I would have is that she arrived at our court dates only a few minutes prior which didn't give much time to talk before hand. Not a big deal though, she was fully prepared once we were called to the stand. Not only was Clair completely squared away, her office assistants were on point as well. Answered questions and returned calls were never an issue. I would recommend Clair and her team to anyone. Money well spent. Thanks again Clair!
Claire is truly a person that puts her heart into her profession, and into her client. She goes to work for you with respect for her profession, and you. She goes at a case, that she has a job to do, and she is going to get it done. She knows her trade, and will take a fight to the end, with a number of kills under her belt, as was in my court case. To me, that's a good lawyer.
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I was so scared when I got my DWLS 3 ticket - I didn't even know my license was suspended!!!
Claire walked me through the process step by step and explained everything in detail. We only had to go into court once and she already had a resolution arranged with the prosecutor. She got 2 of my 3 tickets completely dismissed and the 3rd one was knocked down to just an infraction - so my insurance didn't go up and I only had a small fine.
I would recommend to anyone in this situation. Hopefully I'll never need an attorney again, but if I do, I'll get giving this firm a call!
Reduced my DUI charge to reckless driving. I thought there was no hope and I would have to go to trial but Claire did an outstanding job. Saved my career! I highly recommend Claire I couldn't have done it without her!
Claire was a wonderful, bright Attorney who kept herself focused on my case. She understood my concern and what I was going through. I was accused of domestic violence and I lived 2600 miles away in Tennessee. I would highly recommend this attorney for you legal needs. Kept me in the loop and what our options were and how she was proceeding. Fantastic.