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Tuesday Feb 10, 2015
Friday Sep 05, 2014
Join Oracle in our Journey to be No.1 in Cloud
By Maria Sandu on Sep 05, 2014
Should you wish to apply, please send your CV to Alexandra Tobias at email@example.com.
We invited John McGann, EMEA Sales Consulting, Strategy and
Programs Director to give us more details about the new team that is
being built in Dublin and Bucharest.
"Hi, my name is John McGann and I am part of the Oracle Direct management team, based in Dublin. These are very exciting times in Oracle: as part of our focus on being Number 1 in Cloud, we are starting up a whole new team within the Sales Consulting organization to support the Technology Cloud Platform– specifically our Infrastructure and Platform Services (PaaS and IaaS).
Oracle has a long history of excellence and leadership in Database , Middleware and Development tools, and making these available to existing and new customers via our Public Cloud is a logical next step to offer more choice and flexibility in how our products can be consumed. This change also has implications for how we are organized and operate as a sales team: we need a dedicated group of Sales Consulting or 'Presales' professionals who will be 100% dedicated to growing our Tech Cloud business. This team will focus on supporting customers who may be taking a trial of our Cloud Services, evaluating an initial purchase, or helping them expand their utilization of our services as we continue to release new offerings...[Read More]
Wednesday Aug 20, 2014
Is software support an option for your career?
By Maria Sandu on Aug 20, 2014
We have invited Serban to answer these questions and to give us an overview of one of the biggest technical teams in Oracle Romania. He's been with Oracle for 7 years leading the local PeopleSoft Financials & Supply Chain Support team. Back in 2013 Serban started building a new support team in Romania – Fusion HCM. His current focus is building a strong support team for Fusion HCM, latest solution for Business HR Professionals from Oracle. The solution is offered both on Premise (customer site installation) but more important as a Cloud offering – SaaS.
So, why should a technical person choose Software Support over other technical areas?
"I think it is mainly because of the high level of technical skills required to provide the best technical solutions to our customers. Oracle Software Support covers complex solutions going from Database or Middleware to a vast area of business applications (basically covering any needs that a large enterprise may have). Working with such software requires very strong skills both technical and functional for the different areas, going from Finance, Supply Chain Management, Manufacturing, Sales to other very specific business processes...[Read More]
Tuesday Aug 19, 2014
Meet Matthijs, Dutch Inside Sales Representative for Oracle Direct
By Maria Sandu on Aug 19, 2014
Matthijs: "For the past two years I have been working as an Oracle Direct Core Technology Inside Sales representative for Named Accounts in the Netherlands, based in Malaga, Spain.
In my case, working for the Dutch OD Core Technology team means that I am responsible for the Account Management of Larger companies in the Travel & Transportation and the Manufacturing, Retail & Distribution sector. I work together with the Oracle Field Account Managers and our Field Sales Management in the Netherlands where I am often the main point of contact for customers. This means that I deal with their requests and I manage their various issues, provide solutions and suggestions based on the Oracle Core Technology portfolio. I work on interesting projects with end-customers, making financial proposals and building business cases. It is a very interesting sales environment and for the last two years I improved my skills substantially. This month I will finish my Inside Sales career in Malaga to move to a position within Field Sales in the Netherlands. Oracle Direct has proven to be a great stepping stone for my career...[Read More]
Thursday Aug 14, 2014
Stef is the new 'Most Innovational' employee in Oracle Direct
By Maria Sandu on Aug 14, 2014
Stef is an Inside Sales Representative within Oracle Direct and his main goal is to create additional funnel and to close transactional deals. When he joined Oracle he started working with the Dutch Local Government, but then switched towards commercial accounts. Oracle Direct is a really great opportunity for anyone looking for a successful career in sales.
When you work in sales you need to find new ways of convincing the client to choose you over the competition, so innovative thinking is a must. Stef is one of the reps who find smart new ways to close deals with customers and he is always out for the WIN-WIN. He has developed amazing strategies which generated a lot of revenue. Being really open minded he finds a way to collaborate with all his stakeholders in order to get the best results for all.
What best describes Stef is what one of his colleagues said "Short of hair but never short of great ideas to help you go forward!"...[Read More]
Monday Aug 11, 2014
Meet Brian, the Most Inspirational person in Oracle Direct, Q4 FY14
By Maria Sandu on Aug 11, 2014
Here is what one of the Oracle Direct employees said about Brian: "He is an excellent Manager, the best I have worked for. He has the energy, passion and a "can do" attitude which is contagious. Brian helped me be the best I could be and always had a positive approach and was always available to me and the team. Brian is creative and his management style brings out the best in people and makes work fun."Brian has been with Oracle just over 3 years. He was promoted to this role in January having previously been an Inside Sales Rep selling in the UK Financial Services. We asked him to give us an insight into his role as a Manager and he said: "The most rewarding aspect of my role is watching people join the team just out of college and grow into IT sales people. I enjoy the competitive nature of the job, as a sales representative the competition to deliver "the best quarter" is ferocious and now as a manager I can see that that attitude continues amongst the managers and other lines of business...[Read More]
Wednesday Jul 23, 2014
Life of an Oracle HCM Sales Rep
By Maria Sandu on Jul 23, 2014
"I have been in the Software Industry for 4 years now. My previous job was as a Field Sales Rep on SMB Accounts in Paris and now I'm a HCM Inside Sales Rep for Named Accounts. Being at Oracle allows me to sell a large range of HCM Products, covering aspects from Talent Management (how to develop and train your employees), the Recruitment process (how to detect new Talents for your organization, through normal methods or even thanks to the advantages of the Social networks), to Compensations & Benefits. I am the main point of contact for some of the French markets biggest companies which means that I deal with their requests and I manage their various issues, always providing solutions and suggestions based on our portfolio. There is a wide range of products that companies can select from to grow their business and improve the performance.What I truly like about my job at Oracle is that it has given me an international mindset. Being part of this fast and growing company makes you interact with people from all over the world and deal with a variety of responsibilities. As a HCM Sales representative I help my customers that require international HR processes to find solutions to their requests and challenges, according to their local policies and requirements. For instance, one of my clients which are a well-known French Retail company with shops in many countries around the world has recently decided to maximize their recruiting process. Having chosen Oracle HCM Cloud, they will now be able to support the business growth through the recruiting solutions we provided as well as through the new Social Sourcing techniques which we presented...[Read More]
Tuesday Jun 17, 2014
Family and friends come first
By Maria Sandu on Jun 17, 2014
"Honesty, family support, self-belief, learning to switch off – these are just a few of the non-negotiables for getting on in life. So say a group of Ireland's most successful women, whose achievements are being recognised at a WXN network award ceremony next week."
Maria is among the women who were interviewed by the Irish Times about their priorities in life and how they manage to balance work and private activities.
"Never give up a special family or friend's occasion for a meeting that happens once a month. In life what you will regret is not attending events such as a milestone family birthday, a special anniversary or a son's rugby match. If you have a good team, the works gets done. The more you balance life the more one aspect of it helps another. At work, my boss and I go through the family events of our core team and work our travel commitments around these...[Read More]
Tuesday May 27, 2014
Life at Oracle Russia: Stanislav, Tech Sales Manager
By Maria Sandu on May 27, 2014
Oracle is a place that brings together talented people from various countries and with a diversity of backgrounds. We often invite our employees to speak about their life at Oracle as we think It is important to share an insight into what working for our company looks like.
This time we asked Stanislav to speak about his experience at Oracle. He is Technology Sales Manager at Oracle Russia. He joined the company in July 2011 as a Sales Representative for the Financial sector and had previously worked for another American IT company. He was promoted to a Management position in 2013.
"I have been in this Industry for 15 years and I am now Technology Sales Manager, covering Database, BI and Fusion Middleware products. What I've learned in my role is that respect is one of the most important values a good professional should have. By respecting and embracing everyone's opinions, we create a very good work environment that encourages innovation and change. It eventually leads to a stronger team where people listen to each other and value each other's opinion. On the other hand, It is mandatory to have good knowledge about the area you work in and to continously seek to improve your expertise. Last but not least, working as a team is a top priority and It is something that I've learned at Oracle. There's little you can achieve by yourself comparing to what you can do when you're part of a team."Stanislav shared the top three words that best describe his team and those were: professional, dynamic and smart...[Read More]
Tuesday May 20, 2014
Congratulations to Joana, the Most Helpful person in Oracle Direct EMEA Q3
By Maria Sandu on May 20, 2014
Joana is part of the Core Technology Sales French Team and she's an asset to the EMEA group! She is always helping and taking time to answer her peers' questions. With a very curious personality, she is aware of the Oracle rules regarding approvals, territories, communication plan, HR etc and she's always willing to share her knowledge. Her advice is always appreciated and wise and she's not just helping her team, but every single person who's coming to her. Her leadership and communication skills are very strong and also highly appreciated by her colleagues.
It was a challenge to select just a few thoughts out of the huge number of answers we got from Joana's
colleagues. However, here's what they say about her:
"Joana is just the most helpful person I know in the office. If I have a question, especially about the process, she is the first person I will go to ask for help. Actually, all my colleagues advised me to do so because they do the exact same! Joana always finds a way to dedicate time to others, and with a smile on top of that!...[Read More]
Monday May 12, 2014
Meet Nico, the Most Innovational person in Oracle Direct EMEA of Q3
By Maria Sandu on May 12, 2014
We congratulate Nico for introducing a new way to talk to the customers! He is not only involving Sales Consulting to his customer meetings, but he also surprises the clients. The evidence is his idea of sending a box with engraved Oracle URL apples. The topic was green IT and he positioned products which are related to.
Nico always has great and creative ideas for Demand Generation and he is highly motivated to work hard! He continuously spreads ideas, whether it is about contacting new clients or creating a concept of making our customers understand the company Oracle and its structure better. He is also a great support to the team and has valuable input...[Read More]
Thursday May 08, 2014
Career journeys @Oracle Benelux: Francis, Apps Sales Rep
By Maria Sandu on May 08, 2014
Oracle is organised for success
Today we are discussing working at Oracle with Francis, based in Belgium, and working as an Applications Sales Representative for CRM, ERP and EPM. Francis joined Oracle in 2012 as a Business Development Manager. As of June this year he moved to an Application Sales Representative role focusing on Public Sector, Utilities, Media and Communication in Belgium and Luxembourg. Before joining Oracle he gained multiple years of Sales experience at different IT companies.
Why Application Sales?
What Francis enjoys most about being an Application Sales Representative is the fact you are selling to the decision makers on C-level within a company. This job also gives you the opportunity to see how companies do business and organise themselves and what is going on in the world. You continuously meet very interesting people who have to solve challenging problems and make sure their companies remain successful and achieve the goals they have defined. As an Application Sales Representative you are able to contribute to the success of these companies.
Compared to other Sales jobs Francis had in the past, the difference at Oracle is the amount of focus in the job. At Oracle you are responsible for selling a specific set of products within a specific sector. Francis is very positive about this approach. He can take a deep dive into the challenges his customers are facing in their business processes...[Read More]
Thursday Apr 24, 2014
Career journeys @Oracle Germany: Sigrid, Telekoms IT Expertin
By Maria Sandu on Apr 24, 2014
Hi, ich bin Sigrid, eine Telekoms IT Expertin, leidenschaftlich Köchin und Wanderin. Ich bin seid September 2013 bei Oracle im Team Fusion Middleware Sales für Named Accounts. Mein Fokus ist Deutsche Telekom und Vodafone in Deuschland. Zuvor habe ich 5 Jahren France Telekom in Paris als Key Account betreut. Ich bin seid 13 Jahren in der Industrie Telecoms.
2. Woran arbeiten dein Team und du?
Wir arbeiten eng im Verbund mit dem KAD Team als Vertriebsexperten für unsere jeweiligen Produkte. Oracle's Portfolio ist über die letzte 10 Jahre enorm gewachsen. Dadurch können wir sehr breitflächig unser Portfolio bei den Kunden einbringen, Gesamtlösungen, Cross- und Upselling sind große Themen für uns.
3. Welche Karrierewege sind in Oracle möglich?
Ich glaube die Karrieremöglichkeiten beschränken sich nicht auf das Team, Oracle ist sehr durchlässig und fördert Flexibilität...[Read More]
Wednesday Apr 02, 2014
Career journeys @Oracle UAE: George, Techology Sales Representative
By Maria Sandu on Apr 02, 2014
"My Current role is to sell the Technology stack as well as the industry changing Engineered system into the Financial sector in the United Arab Emirates. The Financial Sector is an exciting and ever-changing industry that keeps you excited and motivated and takes you to a different level of discussion within the business. I work directly with customers and also with our large partner network to deliver solutions to our customers' problems.George and his team are very focused on delivering end to end solution to Oracle's Financial Sector customers...[Read More]
Friday Mar 21, 2014
Career journeys @Oracle: Joeri, HCM Account Manager - Belgium market
By Maria Sandu on Mar 21, 2014
Not a single day is the same!
Today we are talking with Joeri. He is working as a Saas Sales Account Manager in the HCM team in Dublin. Joeri joined Oracle a number of years ago and went through different steps within Oracle before he joined the HCM team.
At the moment he is focussed on selling HR related Cloud
applications to multinational companies in the Belgium market across different
industries. What he enjoys most about selling applications it that your
contacts are not only within IT departments but also within HR teams.
Joeri explains: "In this role you are aiming at developing, supporting and stimulating long term relationships with customers. You are discussing by phone and e-mail what their current situation is and how an Oracle solution can add value for them in reaching their goals and targets i.e. in the process of Talent Management".
What most people do not know about Oracle is the opportunities you receive to develop yourself within the Oracle Direct Sales teams. 'If you want, you can do a new training every day. That is how much content there is available...[Read More]
Oracle has a dedicated Global Team of Recruiters who are responsible for identifying and bringing talented individuals into Oracle. This Blog gives people an insight into what it is like to work at Oracle and provide an avenue to explore
opportunities with us. Initial enquiries can be made to email@example.com
Recent Posts
- Life at Oracle: Win Chang—Committed, Passionate, and Proud
- Life at Oracle: Ryan Pitts—Part of a Winning Team
- Join us at your local Oracle event! - The EMEA Oracle Careers Team
- Do You Really Need to Hire a Rock Star or Do You Just Think You Do by David Talamelli
- Good Recruiters Know How To Close Candidates (It's the ABC's of Recruitment) By David Talamelli
- Why Oracle Direct Sales Consulting is the place for you to work by Toni Yague
- A Second Coming by Sanket Atal
- Oracle Direct is hiring Sales Consultants in Dublin and Malaga!
- Join Oracle in our Journey to be No.1 in Cloud
- Is software support an option for your career?
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Bring the outdoors inside to promote better living
If your veterinary facility sometimes seems more like a lifeless, bland building than a warm, inviting space, it's time to spruce things up. Step one: Go purchase some plants.
A new study published in the Personality and Social Psychology Bulletin says that getting in touch with nature makes people feel and behave better. It's no secret that people are happier and healthier when they regularly experience nature—but the new study proves that the benefits extend to a person's actions and values.
In the study, researchers observed 370 participants who were exposed to either natural or man-made settings. Participants were asked to soak up their surroundings, observing colors and textures and imagining sounds and smells. They then answered questions about the importance of four life aspirations: wealth, fame, connectedness, and community.
People exposed to natural elements rated connectedness (close relationships with others) and community (working toward the betterment of society) higher than they did previously. Participants exposed to man-made elements tended to rate wealth and fame higher than they had.
In another study, researchers gave participants a $5 prize and the choice to keep or donate the money to another anonymous participant. The second participant could then keep the additional $5 or give it back. Again, people exposed to natural elements were more caring, and were more willing to share the money.
Lead author Netta Weinstein says the results highlight the need for more green spaces. So if your practice isn't blessed with picturesque views of the great outdoors, bring nature inside. You'll likely create a more caring and helpful team.
Hot topics on dvm360
Veterinarians: Your clients are going to Google with these cat questions
You might be surprised by what your clients are researching. Plus, get an educational client handout.
Vetcetera: The complex topic of canine fear-related aggression
A guided tour of resources for addressing this popular and complicated subject, featuring advice from Dr. John Ciribassi.
Reality TV and the veterinarian: Discussing mainstream dog training advice with clients
Your clients may be getting behavior advice from cable TV. Get your opinion in the mix.
Blog: Election results pose obstacles for veterinary prescription law
Flip in U.S. Senate's majority may slow progress of Fairness to Pet Owners Act.
7 steps to a better relationship between veterinarians and rescue groups
A DVM in the city shares his advice to veterinary practices for working with rescues.

subset: commoncrawl


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Worktools are configurable in an infinite number of ways with Slatwall.All Organization Worktools
|Surface Materials
|Spec Guide
It's all good. Having an organized workspace feels good. And that's just the start. Employees in workspaces designed around their specific needs and work styles aren't just happier, they're also more productive.
With Organizational Worktools, everyone from today's mobile workers who share temporary touchdown spaces to individual employees occupying the same workspace on an ongoing basis can customize their workspaces to adapt to their needs—making all the difference to them, their work life and their workplace.
Slatwall extends the opportunity configure worktools in an infinite number of ways. With so many options, users have the ability to create personalized spaces, tailored specifically to their needs.
Slatwall can be stacked for multiple layers of storage. It also provides horizontal and vertical capabilities for worktools. Add Slatwall Cable Rings to keep cables bundled together and out of the way. And if you're looking for use with freestanding tables, Slatwall Stanchions are ideal.
Utilizing every inch of space is easy with SlatRail. SlatRail offers users the ability to optimize the use of vertical space in the office environment.
Slatwall can be stacked for multiple layers of storage or display and provides horizontal capabilities for details Organizational Worktools. Get vertical support for SlatRail by mounting SlatRail Stanchions directly to the worksurface.
SlatRail and Slatwall are the physical backbone to our line of Organizational Worktools. Whether desk, panel, or wall-mounted, they enable the user to fully utilize the vertical space above their desks. By taking filing, lighting and the general day-to-day clutter off the desk, Slatrail and Slatwall help create an organizational logic to a space.
Designing for Sustainability
We believe the only way to provide the best office furniture solutions is to ensure they're the best products for the environment. That's why every step of the way – through design, manufacturing, delivery and product lifecycle – we consider the impact of our work on people and on the environment and uncover opportunities to make things better.
Up to
recycled content
Up to
Life Cycle
Life Cycle
Slatwall + SlatRail
Up to 100% recyclable
Made of up to 31% recycled content
LEED Contribution
LEED Contribution
Steelcase supports the U.S. Green Building Council's LEED certification system with products that can contribute to LEED Building Design + Construction (BD&C), LEED Interior Design + Construction (ID&C), or LEED Operations + Maintenance (O&M) certification criteria.
Since the USGBC and its certification partner, GBCI, evaluate each project individually, the role our products play in achieving LEED certification is unique to each project.
Slatwall + SlatRail LEED
- Recycled content
- Regional materials
Certifications can help you choose products that are environmentally sustainable and just right for your project. Slatwall and SlatRail have achieved the following certifications:
Cradle to Cradle
Standard + Optional Features
Standard + Optional Features
- Slatwall tiles mount on panels, walls, benching and freestanding applications
- Available in 12″ and 18″ heights
Slatwall Stanchions
- Slatwall can overhang stanchions 12″ for tiles up to 48″ wide
- Clamps onto desks/surfaces 3/4″ to 3″ thick
- Uses only a 2″ footprint on the worksurface
- Rubber feet under stanchion ensure a tight fit without marring surface
- Worksurface/table must be able to support 60 lbs and be 18″ deep
Slatwall Cable Rings
- Comes in pack with four, 1 1/2″ diameter Cable Rings
- For use on Slatwall or SlatRail
- SlatRail clamps directly to worksurfaces 1/2" to 1 3/4" thick
- Positions top of SlatRail 12 3/4″ above mounting surface, 2″ clearance require under worksurface to accommodate c-clamp
- Slatwall tiles mount on panels, walls, benching and freestanding applications
- Accommodates most Slatwall worktools
SlatRail Stanchions
- Works with standard SlatRail of any length
- Clamps onto worksurfaces from 1/2″ to 1 3/4″ thick
- Uses only 2 1/2″ footprint
- Worksurface/table must be able to support 100 lbs and be 18″ deep
- Accommodates letter, legal and A4 filing
- Handy trough keeps pens and pencils within reach
- Available in two depths and two widths
- Includes rewritable wet erase label inserts to help categorize information for quick reference
- Accommodates up to 40 lbs
Slatshelf Dividers
- Strong dividers support binders, CDs and other reference materials
- Snaps into back wall of Slatshelf
Slatshelf Labels
- Three reusable, wet-erase label inserts
- Label holder accommodates 1/5 hanging folder tab inserts
Global Availability
Global Availability
This product is available in the following regions:
- Central America
- North America
- South America
Not available in your region?
If you're interested in purchasing a product that's not available in your region, please contact your local dealer for purchasing options.


text:
In its sixth annual assessment, SIERRA magazine named Georgia Tech among the nation's "Coolest Schools," a salute to U.S. colleges that are helping solve climate problems and making significant efforts to operate sustainably.
Tim Lieuwen spent five summers with the U.S. Forest Service working and hiking in the wilderness of Alaska and northern Idaho. That experience helped foster an appreciation for the planet's uniqueness that has driven his work as a professor and combustion engineer in Georgia Tech's School of Aerospace Engineering.
For the third time in 2012, Georgia Tech has been recognized on a national level for its sustainable efforts. Most recently, Tech was among 15 schools highlighted by the American College and University Presidents' Climate Commitment (ACUPCC) for reducing carbon emissions, maximizing resources, lowering operating costs and allowing members of the Tech community to also engage in good practices.
With sustainable living becoming a more common concern in homes throughout the country, many people are doing what they can to live greener. However, two recent Georgia Tech graduates are taking these ideas further, thinking big to create ways for major companies to reduce their energy consumption.
In the United States alone, government and private industry together invest more than $3 billion per year in nanotechnology research and development, and globally the total is much higher. What will be the long-run economic returns from these investments, not only in new jobs and product sales, but also from improvements in sustainability?
The Georgia Institute of Technology announced today that it will be upgrading all of its residence hall laundries, bringing them up-to-date environmentally.
"Georgia Tech strives to be a leader in sustainability and environmentally conscious programs," said Rich Steele, acting executive director of Georgia Tech Auxiliary Services. "Our laundries need new equipment on a regular cycle and we wanted to make sure the improvements included energy efficient equipment."
AASHE's award for student research on campus sustainability recognizes outstanding student research that advances the field of campus sustainability. Students are invited to submit research papers on campus sustainability. The papers may be of any length, not previously published, written in English, and completed within the 12-months prior to the application deadline. A version of the winning paper will be published in Sustainability: The Journal of Record. Longer papers will be edited to meet the Journal's length standards.
In honor of Earth Day 2008, Georgia Tech dining services, in partnership with Sodexho, Inc., participated in a nation wide food drive and environmental awareness event. Called
The Georgia Institute of Technology today received the 2008 American Forest & Paper Association (AF&PA) College and University Recycling Award. AF&PA's awards program recognizes outstanding school, business, and community recycling efforts.
Today's awards were presented during the industry's 131st Annual Paper Week, where it was also announced that a record 56 percent of the paper consumed in the U.S. was recovered for recycling in 2007.
For the first time, the Student Center Food Court, Brittain and Woodruff Dining Halls, and both convenience stores, EastSide and WestSide markets have organic foods, including packaged food products, produce and entrees.
"We saw a demand for organic products so we teamed up with the SOS [Students Organizing for Sustainability] organization and created a committee to see what students would like," said Staci Heck, retail operations director, GT Dining.
©2011 Georgia Institute of Technology :: Atlanta, Georgia 30332


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Whew. We're still here. The Mayan doomsday prophecy for Dec. 21 was wrong, something the stock market seemed to anticipate by rising more than 1% on the week. That was an especially decent result in view of the doomsday scenario playing out in Washington, where politicians remain firmly at odds over how to manage the country's finances.
Stocks fell about 1% Friday, halving their intraweek gain, after the House of Representatives failed to pass the so-called Plan B tax bill promised by House Speaker John Boehner. That head-fake refueled worries that Washington won't come to an agreement on the—dare we say it—coming tax hikes and government cuts. Some call it the fiscal cliff.
The past month's stock rally was largely predicated on an assumption that the Obama Administration and House Republicans would come to a compromise in a timely manner—if not exactly by the ostensible Dec. 31 deadline.
Many expected the tax bill's failure to whack equities, but the market's muted reaction suggests there remains a fair amount of expectation among investors that a deal will be struck. The Dow Jones Industrial Average rose 56 points, or 0.4%, on the week, to 13,190.84, while the Standard and Poor's 500 index gained 17 points, or 1.2%, to 1430.15. The Nasdaq Composite added 50 points, or 1.7%, to 3021.01.
"I'm still constructive on the market and cautiously optimistic," says Seth Setrakian, a partner at First New York Securities. "Somewhere there is competence in Washington. There's a middle ground and they have to find it." The market will tolerate extending the deadline into January if there is strong evidence that a deal is coalescing, he adds.
Since plenty of cash remains on the sidelines, market observers generally think indexes will leap in the event of a deal, perhaps to 1500 or more on the S&P 500 in a relatively short period of time. That could be followed by a kneejerk profit-taking round once the details of the tax hikes and government spending cuts are digested. "We could have a deal, but it's what's in the deal that matters," says Kim Forrest, a senior equity analyst at Fort Pitt Capital Group.
WHILE THERE MIGHT BE a fiscal cliff, "it doesn't look like we are about to fall off an economic cliff," Forrest says. On the whole, last week's important economic data continued an upswing seen in recent weeks. U.S. third-quarter gross domestic product was revised upward, for example, to 3.1% from 2.7%. Small-business merger and acquisition activity seems lively, she adds, and that's a good sign for equities.
It has been a year of relatively low stock-market volatility but the longer these fiscal talks drag on, the more likely that will change.
THE ICE MAN CAMETH. Following a proposal last week from the upstart IntercontinentalExchange ice -1.0074162987096498% Intercontinental Exchange Inc. U.S.: NYSE USD230.92 -2.35 -1.0074162987096498% /Date(1427922122487-0500)/ Volume (Delayed 15m) : 663975 AFTER HOURS USD230.92 % Volume (Delayed 15m) : 7760 P/E Ratio 26.838991620079266 Market Cap 26058825105.5768 Dividend Yield 1.125931058375195% Rev. per Employee 1455890 More quote details and news » (ticker: ICE) to acquire NYSE Euronext (NYX) for more than $8 billion, NYSE shareholders face some crucial decisions, potentially right away, even though the deal won't close until the second half of 2013.
NYSE holders can take cash now by selling into the market, or wait for the cash or ICE stock or some combination thereof in 2013. ICE is offering NYSE holders about $33.12 a share, or 0.258 of an ICE share, or a mix of $11.27 in cash plus 0.17 of an ICE share for each NYSE share. ICE is paying a 38% premium to the last NYSE closing price before the deal was announced Thursday. NYSE closed at $32.25, and ICE at $126.25.
There should be plenty of time to cogitate. However, any investor contemplating cash must consider that tax rates on capital gains are likely to go up in 2013 from the current 15%. Selling NYSE shares into the market before year end 2012 could bring a lower tax bill.
And, given the premium being paid, gains there will be if you bought the NYSE stock in 2012, potentially big ones if you purchased after March.
The way things look now, for a long-term-oriented investor, waiting to take all ICE stock might be the soundest way forward. For one thing, it will obviate the capital-gains liability, now or next year. And NYSE holders will get their 3.7% dividend yield while waiting. ICE doesn't have a dividend.
Second, and more important, this looks like a good deal for ICE, a big player in commodities exchanges and a leader in derivatives, particularly on energy. For investors who take its shares, it will be a good way to participate in ICE's future growth and the profits it can wring out of the NYSE acquisition.
"ICE got a great deal," says Martin Leclerc, the chief financial officer at Barrack Yard Advisors, which holds NYSE shares. Given the relatively slower growth prospects for equities trading compared with derivatives, "the combined company is much better positioned to take advantage of the future than NYSE alone."
ICE is mainly interested in NYSE's Liffe, the London-based derivatives market, which is a leader in commodities and interest-rate derivatives products. Growth there is likely to be higher than that of the cash equities trading of the NYSE and the four Euronext exchanges in Paris, Amsterdam, Brussels, and Lisbon.
In the past five years or so, the NYSE trading floor's market share in equities trading has fallen to less than 25% from about 80%. Volume has gone to faster and cheaper nontraditional venues such as the interbank-operated dark pools and BATS Global Markets, among others. Greater regulation, less of an issue for derivatives exchanges, has cost the stock exchanges, as well.
That has fueled consolidation. Following the deal, there will remain in addition to ICE just a handful of major exchanges around the world—the CME Group CME -0.22172949002217296% CME Group Inc. Cl A U.S.: Nasdaq USD94.5 -0.21 -0.22172949002217296% /Date(1427922000826-0500)/ Volume (Delayed 15m) : 1075424 AFTER HOURS USD94.5 % Volume (Delayed 15m) : 18304 P/E Ratio 28.041543026706233 Market Cap 31949863324.848 Dividend Yield 2.1164021164021163% Rev. per Employee 1161380 More quote details and news » (CME), Deutsche Boerse db1.xe 0.07888509071785432% Deutsche Boerse AG Germany: Xetra EUR76.12 0.06 0.07888509071785432% /Date(1427927713000-0500)/ Volume (Delayed 15m) : 629004 P/E Ratio 18.342168674698794 Market Cap 14679579528.8086 Dividend Yield 2.7588018917498687% Rev. per Employee 533282 More quote details and news » (DB1.Germany), Hong Kong Exchange & Clearing 0388.hk -0.20460358056265984% Hong Kong Exchanges & Clearing Ltd. Hong Kong HKD195.1 -0.4 -0.20460358056265984% /Date(1428002784000-0500)/ Volume (Delayed 15m) : 6053390 P/E Ratio 44.04063205417607 Market Cap 221978828750 Dividend Yield 2.203997949769349% Rev. per Employee 7156500 More quote details and news » (0388.Hong Kong), and the Nasdaq OMX Group NDAQ -0.9521005104043974% NASDAQ OMX Group Inc. U.S.: Nasdaq USD50.455 -0.485 -0.9521005104043974% /Date(1427922000263-0500)/ Volume (Delayed 15m) : 867640 AFTER HOURS USD50.455 % Volume (Delayed 15m) : 16436 P/E Ratio 20.510162601626018 Market Cap 8618436667.98523 Dividend Yield 1.1891784758695867% Rev. per Employee 949281 More quote details and news » (NDAQ).
Leclerc attributes about $6 billion of the acquisition value to Liffe and $2 billion to the rest. Moreover, ICE is going to hive off Euronext one way or another. It probably is worth about $1 billion, according to a report from Sandler O'Neill & Partners.
"But [the NYSE's] equity-trading business conditions are probably at a bottom," says Leclerc, and ICE can improve the NYSE's cost structure. "ICE's chief executive, Jeffrey Sprecher, has a phenomenal track record," and the $450 million in cost synergies are "pretty credible….Liffe is a big opportunity for ICE."
Additionally, there's a strong case for the long-term growth of derivatives trading. Regulators are trying to inject more transparency into the relatively opaque world of derivatives trading, notes Leclerc, by pushing such activity onto exchanges and away from over-the-counter markets.
It's going to be a long wait, and that adds to the decision risk. It's hard to predict the regulatory landscape one year out. And there's always the possibility that regulators will object, or that the deal could fall apart somehow, but those are relatively low risks.
Says Leclerc: "If I had to do decide today, I'd take the stock." Waiting for the ICE man seems worth it.
WITH THE HOLIDAYS UPON US, it's the season when everyone, including Barron's columnists, examines the year that's about to close. The U.S. stock market is up 14% year to date, so in purely financial terms, we'd like to look back with fondness.
Alas, we cannot, at least not when it comes to the 80 or so stock and sector calls that this column typically publishes annually. The average price return of the column's stock picks during the course of the past 12 months was 4% as of Dec. 18, significantly below the S&P 500. (This reckoning doesn't include guest-columnist picks. Stocks are measured from the Friday before the item is published, and we've left out group and sector picks, some of which had five names and more listed.)
This performance puts us in a slow, but big boat: Some 75% of domestic long-only mutual fund managers were underperforming their benchmarks as of Dec. 18, according to Lipper. But it's cold comfort.
On the plus side go our positive assessments of the following companies, which were born out by subsequent double-digit-percentage stock outperformance: regional bank BB&T BBT -1.1028468838163632% BB&T Corp. U.S.: NYSE USD38.56 -0.43 -1.1028468838163632% /Date(1427922151244-0500)/ Volume (Delayed 15m) : 4302525 AFTER HOURS USD38.56 % Volume (Delayed 15m) : 26372 P/E Ratio 13.870503597122303 Market Cap 28106060746.0607 Dividend Yield 2.4896265560165975% Rev. per Employee 289311 More quote details and news » (BBT); CVS Caremark CVS -0.9204534444336789% CVS Health Corp. U.S.: NYSE USD102.26 -0.95 -0.9204534444336789% /Date(1427922037813-0500)/ Volume (Delayed 15m) : 4513585 AFTER HOURS USD102.26 % Volume (Delayed 15m) : 79764 P/E Ratio 25.565 Market Cap 117170801913.514 Dividend Yield 1.3690592607079992% Rev. per Employee 639885 More quote details and news » (CVS); the contingent-value rights (GCVRZ) of Sanofi sny 0.9911003236245954% Sanofi ADS U.S.: NYSE USD49.93 0.49 0.9911003236245954% /Date(1427922121248-0500)/ Volume (Delayed 15m) : 1221889 AFTER HOURS USD51.82 1.89 3.7852994191868614% Volume (Delayed 15m) : 19564 P/E Ratio 22.7834816335843 Market Cap 130264862097.852 Dividend Yield 3.240710995393551% Rev. per Employee 393159 More quote details and news » (SNY); Southwest Airlines LUV -1.9187358916478556% Southwest Airlines Co. U.S.: NYSE USD43.45 -0.85 -1.9187358916478556% /Date(1427922075105-0500)/ Volume (Delayed 15m) : 6773812 AFTER HOURS USD43.49 0.04 0.09205983889528194% Volume (Delayed 15m) : 122573 P/E Ratio 26.017964071856287 Market Cap 29946534506.2301 Dividend Yield 0.5523590333716916% Rev. per Employee 402027 More quote details and news » (LUV); railroad Union Pacific UNP -0.8955775090019389% Union Pacific Corp. U.S.: NYSE USD107.34 -0.97 -0.8955775090019389% /Date(1427922406556-0500)/ Volume (Delayed 15m) : 5267984 AFTER HOURS USD107.4 0.06 0.05589714924538849% Volume (Delayed 15m) : 11467 P/E Ratio 18.570934256055363 Market Cap 95451867518.2276 Dividend Yield 2.0495621389975778% Rev. per Employee 508210 More quote details and news » (UNP); GameStop GME -0.47418335089567965% GameStop Corp. Cl A U.S.: NYSE USD37.78 -0.18 -0.47418335089567965% /Date(1427922146735-0500)/ Volume (Delayed 15m) : 2418695 AFTER HOURS USD38.0219 0.2419 0.6402858655373214% Volume (Delayed 15m) : 46179 P/E Ratio 10.612359550561798 Market Cap 4090911034.75739 Dividend Yield 3.8115404976177873% Rev. per Employee 546824 More quote details and news » (GME); and JC Penney JCP 5.826397146254459% J.C. Penney Co. Inc. U.S.: NYSE USD8.9 0.49 5.826397146254459% /Date(1427922085059-0500)/ Volume (Delayed 15m) : 24417874 AFTER HOURS USD8.91 0.01 0.11235955056179775% Volume (Delayed 15m) : 231598 P/E Ratio N/A Market Cap 2566067581.92123 Dividend Yield N/A Rev. per Employee 107518 More quote details and news » (JCP), among others.
In particular, we pointed out how undervalued the initial bid for Great Wolf was during the buyout battle for its shares waged last spring. The stock subsequently rose 41%. We also noted that a split-up of Ralcorp (RAH) into separate branded and private-label food companies would attract buyers, and it did. Con Agra CAG 0.903367095537914% ConAgra Foods Inc. U.S.: NYSE USD36.86 0.33 0.903367095537914% /Date(1427922196114-0500)/ Volume (Delayed 15m) : 4425381 AFTER HOURS USD37.03 0.17 0.4612045577862181% Volume (Delayed 15m) : 53461 P/E Ratio 36.79377121181873 Market Cap 15600209110.0439 Dividend Yield 2.7129679869777537% Rev. per Employee 492771 More quote details and news » (CAG) recently agreed to buy Ralcorp. The return for the two companies has been 36%.
However, these must be weighed against lousy bullish calls on Staples spls 0.7675775253300583% Staples Inc. U.S.: Nasdaq USD16.41 0.125 0.7675775253300583% /Date(1427922000347-0500)/ Volume (Delayed 15m) : 6766737 AFTER HOURS USD16.41 % Volume (Delayed 15m) : 45909 P/E Ratio 78.14285714285714 Market Cap 10430330689.3178 Dividend Yield 2.9250457038391224% Rev. per Employee 284443 More quote details and news » (SPLS), down 25%; NetApp ntap -0.535815002820079% NetApp Inc. U.S.: Nasdaq USD35.27 -0.19 -0.535815002820079% /Date(1427922000733-0500)/ Volume (Delayed 15m) : 2769543 AFTER HOURS USD35.27 % Volume (Delayed 15m) : 18238 P/E Ratio 18.18041237113402 Market Cap 11054938238.747 Dividend Yield 1.8712787071165295% Rev. per Employee 498263 More quote details and news » (NTAP), off 28%; Joy Global JOY -0.6636038795303726% Joy Global Inc. U.S.: NYSE USD38.92 -0.26 -0.6636038795303726% /Date(1427922345264-0500)/ Volume (Delayed 15m) : 835754 AFTER HOURS USD38.92 % Volume (Delayed 15m) : 596 P/E Ratio 12.636363636363637 Market Cap 3815152529.71649 Dividend Yield 2.055498458376156% Rev. per Employee 236539 More quote details and news » (JOY), a maker of mining equipment, down 22%; and coal stocks such as Arch Coal ACI -0.9900990099009901% Arch Coal Inc. U.S.: NYSE USD0.99 -0.0099 -0.9900990099009901% /Date(1427922014254-0500)/ Volume (Delayed 15m) : 3051945 AFTER HOURS USD0.99 % Volume (Delayed 15m) : 13299 P/E Ratio N/A Market Cap 212671720.335333 Dividend Yield 1.0101010101010102% Rev. per Employee 586357 More quote details and news » (ACI), down 26%, and Alpha Natural Resources ANR 3.0103010301030104% Alpha Natural Resources Inc. U.S.: NYSE USD1.03 0.0301 3.0103010301030104% /Date(1427922035209-0500)/ Volume (Delayed 15m) : 6679222 AFTER HOURS USD1.04 0.01 0.970873786407767% Volume (Delayed 15m) : 114904 P/E Ratio N/A Market Cap 221752812.716975 Dividend Yield N/A Rev. per Employee 482035 More quote details and news » (ANR), down 33%.
Regarding Alpha, we checked back with David Steinberg, a deep-value portfolio manager with DLS Capital Management. He's continued to load up on coal stocks. Global coal demand is going to surprise folks, and natural-gas prices—an alternative—have begun to rise, he says. We think in the long run he'll be right about coal, but it's been a tough year.
The worst pick was small-cap Poseidon Concepts (PSN.Canada), which makes water-holding tanks for energy-exploration firms. Day rental rates have fallen sharply and drilling activity has dropped, leading to a big unexpected decline in third-quarter earnings. The stock is down 75%. That's just one call out of many, but it's a painful loss. Without our coal and Poseidon picks, we'd be up 6%, a little better but still not great.
This column also includes the occasional bearish items. Here, too, performance is nothing to write home about, though the average rise of 9.5% for our skeptical calls is mainly the result of one spectacularly bad pick: Schiff Nutrition International (SHF), recently bought by Reckitt Benckiser Group RB.LN 0.08620689655172414% Reckitt Benckiser Group PLC U.K.: London GBP5805 5 0.08620689655172414% /Date(1427924105000-0500)/ Volume (Delayed 15m) : 1383205 P/E Ratio 0.22407812510514105 Market Cap 41533452000 Dividend Yield 2.7217915590008612% Rev. per Employee 238167 More quote details and news » (RBGPY).
Without that, our skeptical calls would be down a more respectable average 1.4%. Our pessimistic views of truck maker Navistar NAV -2.3389830508474576% Navistar International Corp. U.S.: NYSE USD28.81 -0.69 -2.3389830508474576% /Date(1427922122276-0500)/ Volume (Delayed 15m) : 538607 AFTER HOURS USD28.81 % Volume (Delayed 15m) : 2031 P/E Ratio N/A Market Cap 2403837001.80054 Dividend Yield N/A Rev. per Employee 715519 More quote details and news » (NAV), Argentine oil company YPF ypf 2.6958105646630237% YPF S.A. ADS U.S.: NYSE USD28.19 0.74 2.6958105646630237% /Date(1427922121614-0500)/ Volume (Delayed 15m) : 1031828 AFTER HOURS USD28.19 % Volume (Delayed 15m) : 561 P/E Ratio 10.087672213276077 Market Cap 14782488568.0206 Dividend Yield 1.028087974459028% Rev. per Employee N/A More quote details and news » (YPF), McDonald's MCD -1.1802134646962232% McDonald's Corp. U.S.: NYSE USD96.29 -1.15 -1.1802134646962232% /Date(1427922013141-0500)/ Volume (Delayed 15m) : 7429894 AFTER HOURS USD96.3 0.01 0.010385294423096894% Volume (Delayed 15m) : 54858 P/E Ratio 19.85360824742268 Market Cap 93651439514.4507 Dividend Yield 3.531000103852944% Rev. per Employee 65336.4 More quote details and news » (MCD), Mattress Firm Holding mfrm -3.3744974152785754% Mattress Firm Holding Corp. U.S.: Nasdaq USD67.29 -2.35 -3.3744974152785754% /Date(1427922000258-0500)/ Volume (Delayed 15m) : 233165 AFTER HOURS USD67.4176 0.1276 0.18962698766532918% Volume (Delayed 15m) : 2989 P/E Ratio 49.11678832116788 Market Cap 2444503341.45996 Dividend Yield N/A Rev. per Employee 467762 More quote details and news » (MFRM), and the popular Internet real estate site Zillow z -3.0059820538384847% Zillow Group Inc. Cl A U.S.: Nasdaq USD97.285 -3.015 -3.0059820538384847% /Date(1427922000052-0500)/ Volume (Delayed 15m) : 1521743 AFTER HOURS USD97.69 0.405 0.41630261602508095% Volume (Delayed 15m) : 5697 P/E Ratio N/A Market Cap 5779130507.88677 Dividend Yield N/A Rev. per Employee 268225 More quote details and news » (Z), all turned out to be well founded.
Nevertheless, with a 4% rise, a lump of coal is in order and we'll have to try harder next year. We'll consider 2012 a nonrecurring loss and get right back on our horse for 2013.
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Epidemiology & Molecular basis of cancer Epidemiology: 1. Cancer incidence: – Males: prostate, lung & colorectal. – Females: breast, lung & colorectal. 2. Geographic incidence: – Ca stomach: 7-8 x Japan cf US. – Ca lung: 2 x US cf Japan. – Ca skin: 6 x New Zealand cf Iceland. Environmental influences, UV rays, asbestos, obesity, alcohol, cigarette smoking. Almost everything one does to gain a livelihood or for pleasure is fattening, immoral, illegal or even worse ONCOGENIC. Epidemiology contd.. 3. Age: – – – – > 55 yrs. of age. Females: 40-79 yrs. Males: 60-79 yrs. Children: < 15 yrs. 4. Genetic predisposition to cancer: – Autosomal dominant inherited cancer syndromes. – Defective DNA repair syndromes. – Familial cancers. Genetic predisposition to cancer: Autosomal dominant inherited cancer syndromes: Point mutation in single allele of a tumor suppressor gene. 2nd allele: chromosome deletion or recombination. – – – – Retinoblastoma- 40% inherited. Familial adenomatous polyposis- Colonic Ca. MEN 1 & 2. HNPCC Syndrome. Characteristics : – Tumors involve specific sites in each syndrome. – Within each group, a/w specific marker phenotype. – Incomplete penetrance and variable expressivity. Defective DNA repair Syndromes: DNA instability Autosomal recessive inheritance Xeroderma pigmentosum, ataxia telangiectasia, Bloom syndrome, HNPCC ( autosomal dominant): inactivation of DNA MMR gene. Familial cancers: Ca colon, breast, ovary, brain, melanomas. Characteristic features : – Early age at onset. – Occur in 2/ more close relatives of index case. – Multiple or bilateral cancers. – No specific marker phenotypes. 5. Nonhereditary predisposing conditions: Regenerative, hyperplastic and dysplastic proliferations are fertile soil for the origin of a malignant tumor. Chronic inflammation: – Virchow proposed that cancer develops at sites of chronic inflammation. – Ulcerative colitis, Crohn disease, H.pylori gastritis, viral hepatitis, chronic pancreatitis. – Cytokines →stimulate growth of transformed cells. – Chronic infl. → ↑ pool of tissue stem cells → effect of mutagens. – Reactive O2 Species → genomic instability. ?COX-2. 5. Nonhereditary predisposing conditions: Precancerous conditions: – Chronic atrophic gastritis, chronic ulcerative colitis, solar keratosis, leukoplakia- oral, vulva, etc.. – Majority: no malignancy emerges. – Cancers arising in benign tumors: • Villous adenoma- colon (50%). • Leiomyosarcoma in leiomyoma. • Carcinoma ex pleomorphic adenoma. Chronic atrophic gastritis: Atrophic gastritis. Autoantibodies against parietal cells. Pernicious anemia. Gastric carcinoma and carcinoid tumor. Ulcerative colitis: Ulceroinflammatory disease of mucosa and submucosa, involving colon. Islands of regenerating mucosa forming pseudopolyps. Dysplasia and frank carcinoma. Caused by DNA damage d/t DNA repair deficiency and genomic instability. Leukoplakia: White patch that cannot be scraped off and Cannot be characterized as any other disease. 5-25% of these are pre-malignant. Hyperkeratosis overlying a thickened, acanthotic epithelium, with marked dysplastic changes. CANCER AND GENETICS MOLECULAR BASIS OF CANCER Nonlethal genetic damage Clonal expansion of a single precursor cell that has incurred the genetic damage Principal targets of genetic damage – 4 classes of normal regulatory genes : – – – – Protooncogenes Tumor suppressor genes Apoptosis regulating genes DNA repair genes Multistep process – genetic and phenotypic • In normal tissues, the rates of new cell growth and old cell death are kept in balance • In cancer, this balance is disrupted Cancer Cell Do Not Grow Faster Than Normal Cells. Rather, Their Growth is Just Uncontrolled. Acquired (environmental) DNA damaging agents: Chemicals Radiation viruses Normal cell DNA Damage Successful DNA repair Failure of DNA repair Mutations in the genome of somatic cells Inherited mutations in: Genes affecting DNA repair Alterations of genes that regulate apoptosis Activation of growthpromoting oncogenes Inactivation of suppressor genes tumor Unregulated cell proliferation decreased apoptosis and Clonal expansion Additional mutations (progression) Heterogeneity Malignant neoplasm Flow chart depicting the molecular basis of cancer Fig 7-27 Essential alterations for malignant transformation: Self-sufficiency in growth signals-oncogenes. Insensitivity to growth signals-Tumor Suppressor Genes. Evasion of apoptosis. Defects in DNA repair. Limitless replicative potential. Sustained angiogenesis. Ability to invade and metastasize. Oncogenes Cell cycle Apoptosis Tumor Suppressor Angiogenesis Inv. and Mets Hanahan and Weinberg, Cell 100: 57, 2000 CELL CYCLE Daugther cell Mitosis Gateway Growth Factors S DNA replication CELL CYCLE Cell cycle inhibitors Control Point • CyclinD / cdk 4 • Cyclin E /cdk 2 G1 M • Cyclin B /cdk 1 S G2 • Cyclin A / cdk 2 External signals (growth factors, integrins) MYC, RAS.. DNA damage, cell sress Feedback reg. Cyclin D + CDK4 Cyclin D/CDK4 (active c) p16INK4 RB phosphorylation p53 MDM2 p21 Active E2F Cyclin E transcription CYCLIN E CDK2 Cyclin E/CDC2 G1 S What are the genes responsible for tumorigenic cell growth? Normal Proto-oncogenes Tumor suppressor genes + ++ Cell growth and proliferation Cancer Mutated or "activated" oncogenes Loss or mutation of Tumor suppressor genes Malignant transformation ONCOGENES Oncogenes are mutated forms of cellular protooncogenes. Protooncogenes code for cellular proteins which regulate normal cell growth and differentiation. Five types of proteins encoded by protooncogenes participate in control of cell growth: Class I: Growth Factors Class II: Receptors for Growth Factors Class III: Intracellular Signal Transducers Class IV: Nuclear regulatory proteins Class V: Cell-Cycle regulators Functions of Cellular Proto-Oncogenes 1. Secreted Growth Factors 2. Growth Factor Receptors 3. Cytoplasmic Signal Transduction Proteins 4. Nuclear Proteins: Transcription Factors 5. Cell Growth Genes Role of proto-oncogenes and oncoproteins Protooncogenes function in regulating growth and proliferation of the cell. – Growth factor ligands & receptors – Signal transducers – Transcription factors – Cell cycle components Oncoproteins : Similar function, but endow the cell with selfsufficiency in growth Oncogenes are usually dominant (gain of function) • cellular protooncogenes that have been mutated (and "activated") • cellular protooncogenes that have been captured by retroviruses and have been mutated in the process (and "activated") • virus-specific genes that behave like cellular protooncogenes that have been mutated to oncogenes (i.e., "activated") The result: Overproduction of growth factors Flooding of the cell with replication signals Uncontrolled stimulation in the intermediary pathways Cell growth by elevated levels of transcription factors Oncogenes Proto-oncogene = ras Oncogene = mutated ras Always activated Always stimulating proliferation TUMOR SUPPRESSOR GENES The products of these genes regulate / suppress further cell proliferation Involved in cell cycle control, regulation of apoptosis etc. Function as : Transcription factors Cell cycle inhibitors Signal transduction molecules Cell surface receptors Regulators of cell response to DNA damage If abnormal : INSENSITIVITY TO GROWTH INHIBITORY SIGNALS TUMOR SUPPRESSOR GENES Disorders in which gene is affected Gene (locus) DCC (18q) Function cell surface interactions transcription Familial unknown Sporadic colorectal cancer lung cancer WT1 (11p) Wilm's tumor Rb1 (13q) transcription retinoblastoma small-cell lung carcinoma p53 (17p) transcription Li-Fraumeni syndrome breast cancer breast, colon, & lung cancer breast/ovarian tumors BRCA1(17q) transcriptional BRCA2 (13q) regulator/DNA repair Differences: Dominant oncogenes Alleles in normal cells Two Tumor suppressor genes Two Alleles mutated to produce effect Function of protein Germline mutations identified Mutations One Enhanced Rare- RET Activating, gain in function, dominant Two Reduced Many-RB, p53 Inactivating, loss of function, recessive RB Gene Product of RB gene is a nuclear phosphoprotein that plays a key role in regulating the cell cycle In quiescent cell : ACTIVE, HYPOPHOSPHORYLATED STATE G1/S : INACTIVE HYPERPHOSPHORYLATED STATE KNUDSON TWO HIT HYPOTHESIS IN FAMILIAL CASES Familial RB (%30) RB rb Normal cells RB LOH rb RB rb Inactivation of a tumor suppressor gene requires two mutations, inherited mutation and somatic mutation. Normal cells Tumor cells KNUDSON TWO HIT HYPOTHESIS IN SPORADIC CASES Normal Cells RB RB RB RB RB LOH RB Mutation Tumor cells Inactivation of a tumor suppressor gene requires two somatic mutations. E2F-RB (hypo) – inhibitor, brake S Increased Cyclins (D,F) RB ( hyper): E2F released G1 Growth factors Increased transcription factors (E2F) Mutation at any step somatic/ inherited Unregulated progression to S phase NO cell cycle control: MALIGNANCY External signals (growth factors, integrins) MYC, RAS.. DNA damage, cell sress Feedback reg. Cyclin D + CDK4 Cyclin D/CDK4 (active c) p16INK4 RB phosphorylation p53 MDM2 p21 p53 Located on chromosome 17p13.1 Most common target for genetic alterations in human tumors Li Fraumeni syndrome : Inherit 1 mutant p53 allelle Younger age, multiple primary tumors Ca breast, adrenal cortex, sarcomas, brain tumors and leukemias. MOLECULAR POLICEMAN Prevents propagation of genetically damaged cells It acts in the cell cycle only when DNA is damaged DNA damage : Rapid increase in p53, protein kinases & ATM (which phosphorylate p53): Apoptosis Important in therapy Tumors with normal p53 respond well to chemo and radiotherapy APC-ß catenin pathway Down regulation of growth promoting signals Eg : APC, NF-1. APC loss : Pathogenesis of colon tumours, hepatoblastoma, hepatocellular carcinoma Component of WNT signalling pathway Downregulates ß catenin in cytoplasm Loss of APC Increased ß catenin – binds to TCF in nucleus Upregulates cell proliferation ( incr transcr of c-myc etc) ß catenin- E cadherin axis defects – Reduced cell adhesion APC-ß catenin pathway Other tumour suppressor genes NF-1, NF-2 genes VHL PTEN WT-1 Cadherins PTCH BRCA-1 & BRCA-2 Genes Involved in : Transcriptional regulation Homologous recombination of DNA repair Chromatin remodelling Compo of G1/S checkpoint Mutations of either – Breast & Ovary Ca Mutation of BRCA-1 –Ca: prostate, colon Mutation of BRCA-2 – Ca : male breast, pancreas, melanoma Genes that regulate apoptosis Inhibit apoptosis: Bcl-2 gene (18q21), Bc1-x Favor apoptosis: BAX (p53), BID (p53): chemotherapy MYC : triggers proliferation; Bcl-2 : prevents cell death. IMPORTANCE OF DNA REPAIR Tumor Progression Cellular Multiple mutations lead to colon cancer Genetic changes --> tumor changes Development of sustained angiogenesis Tumors stimulate the growth of host blood vessels : Angiogenesis. TUMORS Angiogenic switch Incr Production of angio factors/ loss of angio inhibitors (eg : wild p53). VEGF, bFGF (tumor cells, stromal cells, infl cells) Recruit endoth cell precursors / sprouting of existing capillaries NEOVASCULARISATION Leaky vessels ( VEGF ) Tortuous, irregularly shaped. Anti angiogenic factors Dual effect of neovas on tumor cells GFs secreted : PDGF Stimulate growth of tumor cells, Supplies nutrients and oxygen Important for metastasis Currently important modalities of therapy : Angiogenic inhibitors Abs to VEGF, VEGF-R2,
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[Feature Interview] Cashius Green + Pheo: Ordained Rap
Last month, Hazzle and I were invited to check out the first annual, L.A. edition of Broccoli City – which has already experienced huge success on the East Coast – and we were definitely excited to check out the lineup. 697 more words
Broccoli City Festival 2014 Recap
Broccoli City executed its multi-city environmental celebration in Washington, DC on Saturday, April 19, 2014 and Los Angeles, CA on Saturday, May 3, 2014 — reaching well over 10,000 multicultural youth and a list of celebrities that included Selena Gomez, Karrueche Tran, and Cody Simpson, just to name a few. 70 more words
Rockin' With The 5th: JoJo
Having sold millions of albums worldwide and even lending her talents to television and movies, teen sensation turned full fledged R&B songstress, JoJo, really doesn't need much of an introduction. 843 more words
Does This BLACK Match?
Hello Guys and Gals,
I'm back, and I have to fill you in on my most current outings! So what better way than a blog post right? 305 more words
Recap: Broccoli City Festival Feat. Cam'Ron, Just Blaze, Vashtie, And More
A cool, calm, and collected Cam'Ron returned to Washington D.C. Saturday (April 19) evening for the second annual Broccoli City Festival. Cam was humble, and far less flashier than when he last visited the city — five years ago. 200 more words
DMV First Music Fest of the Year: BC Fest
In honor of Earth Day, Broccoli City will be holding a music festival, featuring Cam'Ron and DC's own Reesa Reene. The festival will be all ages, held April 19 at the Gateway Pavilion in Washington, DC. 13 more words


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815 Savage Road
Charleston, South Carolina, 29414
Commute to Downtown Charleston
Most errands require a car.
Score Details
815 Savage Road has a Walk Score of 29 out of 100. This location is a Car-Dependent neighborhood so most errands require a car.
This location is in Charleston.
Explore how far you can travel by car, bus, bike and foot from 815 Savage Road.
This location is in the city of Charleston, SC. Charleston has an average Walk Score of 34 and has 120,083 residents.


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Freelance Web & Graphic Design - 100% Remote
If you provide any design services and are looking for extra work, then we have clients ready to hire you.
Type of work needed includes:
Mobile Apps
Marketing Materials
Video Production
Mar 22 -
Software Development Engineer - Applications
Software Development Engineer - Applications - Intentional Software - www.intentsoft.com
Are you the person on your team who is always looking for the precise abstractions to express the solution? Do you believe that the process of writing software applications is far ...
Mar 19 -
Web Developer - 177030
JobStand.net is currently looking for a talented Web Developer to join a worldwide seller of Motorcycle related parts & accessories. They're currently looking to expand their web / e-commerce capabilities and are seeking a talented web developer capable of servicing their ...
Feb 23 -
Online Editorial Producer - in Germany and France!
Valente is seeking an Editorial Producer support one of our largest customers in the Redmond, WA area.
We are looking for two Producers, one to be onsite in Germany and the other to be in France.
Producer – for an (internet) channel programming
The Programming team is ...
Feb 18 -
Graphic Designer 2
You will work under the direction of the Art Director with a small team of designers & strategists that plan and innovate covering the scope of Xbox, Windows, and much more.
You are a strong, collaborative designer who wears many hats, thinks conceptually and strategically ...
Feb 6 -
UI Technical Artist
Our studio is looking for a Technical Artist to help craft the HUD and front end menu UI for one of the most exciting and creative intellectual properties in the industry.
While this is not a developer role, we do expect a technically adept individual that can quickly ...
Jan 29 -
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A high level of pesticides was found in 509 samples out of 16,790 comprising veggies, fruits, spices, rice, wheat and other food items in 2013-14, said a latest government report.
If you wish to encourage your kids to eat healthy and want them to eat vegetables without making much fuss, starting early and often could be the key.
Unlike adults, lifestyle-related and environmental risk factors are not considered to play a major role in cancers in teens.
A new study has revealed that children tend to dislike vegetables because they may be programmed to avoid plants as part of a survival strategy left over from our days in the wild.
Eating plenty of fruits and vegetables can help beat mental health disorders.
Want to stay slim? Eat lots of fresh fruit and vegetables daily to resist the temptation of waist-expanding treats.
Mothers who want their children to like vegetables should eat them during pregnancy.
Eating legumes at least three times a week and brown rice at least once a week can reduce your risk of colon polyps by 33 percent and 40 percent respectively, thereby decreasing your risk for colorectal cancer to a great extent, according to a new research.
African American women who consumed a diet high in vegetables and fruit gained less weight over a 14-year period than those who consumed a diet high in red meat and fried foods.
African American women who consumed a diet high in vegetables, fruit gained less weight.
A new study has found that bribing children is the best way to get them to eat vegetables.
A healthy diet is crucial to achieving the most desirable complexion, says a new study.
Veggies available in Delhi wholesale market are contaminated with toxic chemicals.
Research has shown how veggies help reverse or prevent cancers and other aging-related diseases.
High blood levels of the antioxidant alpha-carotene in yellow, green veggies appear to reduce the risk of dying over a 14-year period.
Day in Pics: 30th March
Showbiz World - March 30, 2015
Cricket World Cup: Team India members return home


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Reports: Urbanski's wife says Goodell reneged on promise of financial help
Updated: February 17, 2008, 1:10 PM ETESPN.com news services
Kathy Urbanski, whose husband, Tommy, was paralyzed in a melee at a Las Vegas nightclub that involved now-suspended Tennessee Titans cornerback Adam "Pacman" Jones, said NFL commissioner Roger Goodell promised to help the family pay its mounting medical expenses, according to published reports.She now says Goodell has reneged on his offer. "Roger Goodell told me, 'You don't have to call us. We'll get in touch with you,'" Kathy Urbanski told the New York Daily News for a story published Sunday. "Now I realize he meant, 'Don't call us, we'll call you.'" The Urbanskis' plight also was reported by the Las Vegas Review-Journal in recent weeks. Tommy Urbanski was one of three people wounded in the shooting outside the Minxx Gentleman's Club. He still has a bullet in his spine from the Feb. 19, 2007, incident, which occurred during NBA All-Star Weekend. Kathy Urbanski told the Daily News she and her husband received two calls from the league about its desire to offer financial help, but when the Urbanskis called back, they received no response. Prior to Super Bowl XLII, Goodell addressed the Urbanskis' difficulties. "I'm sorry about the tragedy the family is going through, but I don't feel we have any responsibility," Goodell said. Goodell added that Kathy Urbanski agreed with him during their discussion, but Urbanski later disputed the commissioner's recollection of their conversation. "This is a David-and-Goliath situation, with working people against a very greedy and evil corporation called the NFL," she told the Daily News. With a civil lawsuit filed by the Urbanski family pending, Clark County District Court Judge Jessie Walsh is due to hear arguments Wednesday on the NFL's claim that Nevada courts lack the reach to hold the league responsible in the wounding of Tommy Urbanski. Previously, the Nevada court ruled the Titans held no legal responsibility for Jones' actions that night. The Urbanskis are challenging that decision. Jones pleaded no contest Dec. 6, 2007, to a reduced charge of conspiracy to commit disorderly conduct, a gross misdemeanor, in regards to his actions in the brawl inside the Las Vegas club. No one has been charged with the shooting outside, and Jones' lawyer, Robert Langford, has declined to say if Jones knows the identity of the gunman. The Associated Press contributed to this report.
Adam "Pacman" Jones was suspended for the 2007 NFL season amid several legal skirmishes. His playing future rests in the hands of commissioner Roger Goodell, who expects to weigh a possible 2008 reinstatement before training camp opens in July. A look at coverage of Jones:
NewsAugust 2008
• Jones submits NFL reinstatement letter
June 2008
• Goodell grants Pacman partial reinstatement
May 2008
• Pacman meets with commish Goodell
• Pacman pays gambling debt; case closed
• Cowboys could use Pacman at wide receiver
• Source: Meeting must happen before reinstatement
• Pacman puts house on market for $1.8M
• Emmitt's advice to Pacman: Make better choices
• Report: Suspect accuses Pacman of framing him
April 2008
• NFL approves Jones' trade to Cowboys
• Pacman signs Cowboys contract
• Hall of Famer Brown offers to help Pacman
• Police: Pacman paid 'extortion' cash in shooting
• Police make arrest in strip-club shooting
• Goodell: Trade won't affect reinstatement
• Pacman: Trade first, then reinstatement
• Sources: Pacman offers pay concession to Titans
• Pacman returns to Atlanta routes for charity work
• Goodell: Pacman decision to come before camp
March 2008
• Source: Cowboys-Titans Pacman talks stall
• Report: Pacman thinks he's through with Titans
• Report: Cowboys add to trade offer for Pacman
Feb. 2008
• Pacman may have to re-petition Goodell to return
• Source: Pacman still frequenting strip clubs
Jan. 2008
• NFL asking to be dropped from Pacman lawsuit
• Ga. assault complaint against Pacman withdrawn
• Pacman accused of punching woman at strip club
• Judge cuts Titans out of Pacman lawsuit in Vegas
Dec. 2007
• NFL denies Pacman's appeal to return in 2007
• Union appeals Pacman's 'excessive' suspension
• Pacman pleads no contest in strip club melee
• Goodell reviewing union Pacman appeal
Nov. 2007
• Judge accepts 'Pacman' plea agreement
• Union appeals to commish to reduce Pacman ban
• Report: Some Titans want Pacman back
• Pacman won't be reinstated early
Oct. 2007
• Strip club manager sues Pacman, Titans, NFL
• Report: Pacman says he's earned early return
Sept. 2007
• Pacman wins tag-team title
August 2007
• Pacman to try hand at hip-hop
• Pacman to set record straight in interview
• Pacman makes TNA debut
• Pacman's ticket violations dismissed
• Arrests? By Pacman's count, he's only had two
July 2007
• Pacman defense expected to enter not guilty plea
• NFL may allow Pacman to work out with Titans
• Lawyer: Deputy pledged to pull over Pacman
• Vegas charges may affect Pacman's Tenn. plea
June 2007
• Vegas bouncer sues Pacman
• VY: Teammates feel Pacman doesn't care
• Cops seek Pacman about shooting involving crew
May 2007
• Paralyzed victim rebuilds life
• Sources: Pacman at strip club before hearing
March/April 2007
• Pacman takes out ad to apologize
• NFL bans Jones for 2007 season
• Pacman-related incidents
Analysis• Why Jerry Jones takes risks
• Third-and-Short: Player conduct
• Pasquarelli: Titans picking up the pieces
• Garber: Pacman gifted on field, troubled off it
• Ex-Titans GM Reese: We tried to help Pacman
- McShay: Mariota moves up in Mock Draft 4.0
- Sando: Free-agency grades for all 32 teams
- Kiper: 10 safest picks in draft
- Joyner: Colts need more help for Luck
- McShay: Winston looks like No. 1 | Top 32


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New Selena Gomez,Vanessa Hudgens R Rated Spring Breakers Movie Trailer Released Online
New Selena Gomez,Vanessa Hudgens R Rated Spring Breakers movie trailer released online. Recently, this new red band/r-rated movie trailer (below) for Selena Gomez and Vanessa Hudgens' new comedy flick "Spring Breakers," hit the net,and it looks as wild as ever with a lot of cussing,threesome action,bong hits, and more.
The threesome action goes down with Vanessa and Pretty Little Lairs starlet Ashley Benson,and James Franco,and it looks very hot. We also see Selena's character getting very upset over all the trouble they're getting into. Poor thing. Check it out,below. The movie stars: James Franco, Selena Gomez, Vanessa Hudgens, Ashley Benson, Rachel Korine, Heather Morris,and Gucci Mane.
In the new flick, 4 wild and crazy college chicks get thrown right in jail after robbing a restaurant for Spring Break cash. From there, their problems only get worse after they get bailed out by a rapping drug dealer who wants them to do even more dirty work for him. It hits theaters on March 22nd,2013. Stay tuned. Follow us on Facebook by Clicking Here. Follow us on Twitter by Clicking Here.
Recent Posts from On The Flix:
- New Flash Episode 18,Season 1 Official Spoilers,Description Revealed By CW
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- New NCIS Los Angeles Season 6,Episode 20 Intense Spoiler Promo Clip Hit The Net
- New Castle Season 7,Episode 20 Intriguing Spoiler Promo Clip Hit The Net
- New Following Season 3,Episode 7 Intense Spoiler Promo Clip Hit The Net


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Cabaret Invasion
Students who worked with the Philadelphia-based performers while they were on campus in late January, conducting workshops and producing three shows of Wide Awake: A Civil War Cabaret, say the experience was truly one-of-a-kind.
"It was my first time working in a truly collaborative environment where everyone was involved in the decision making progress. It was great to see how everyone's ideas were explored and chosen or discarded. I learned a lot about devised theater, also about reaching out and stepping out of comfort zones in order to reach audiences and performers. Bringing this work not only to Chestertown but to Washington College made people think outside of the box. When they visited classes, I believe they had more of an impact on the students than they know; it was refreshing to see this positive energy between theater, history and pop culture, how they work together, and what can be accomplished."
—Phaedra Scott '14, Drama and History majors
Assistant stage manager to Bearded Ladies Stage Manager Bayla Rubin
"The Beards are wonderful. I've been quoted as saying the show was a 'religious experience.' It was like nothing I've ever seen before or expected, and I loved every second of their company and work. I would love to work with them again! I can't wait to see them again in Philadelphia. It is so valuable having a working theater group on campus; it really showed us all not only what you can do with a theater education professionally, but also introduced us to different ways to make art. And to make people laugh."
—Nicole Capobianco '16, Drama major
Departmental Costume Shop Manager who worked closely with the Bearded Ladies' costumer Rebecca Kanach and her assistant Fritz McGlynn.
"Their process of devised theater challenged my script-based understanding of drama and inspired me to tell stories in new ways. Working alongside these enormously generous professionals, we learned to manipulate site and script in order to communicate exciting ideas. Having a working theater company visit the campus reaffirmed my ambition to pursue theater as a career. I witnessed firsthand the passion and professionalism crucial to producing a theatrical piece like Wide Awake. I heard the campus buzzing with talk of musical outbursts, ten-foot-tall hoop skirts, and the general upheaval of history as we think we know it. The Bearded Ladies reminded me that theater can form new perspectives as well as entertain. I am thankful that such a provocative and high-energy group visited our campus and am currently negotiating an internship with the Bearded Ladies for this summer."
—Valerie Dunn '15, Drama and English majors, creative writing minor
Worked on set construction and deconstruction, as well as workshops and dramaturgy with the Bearded Ladies on her own senior thesis.


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My priorities are making more money so I can give my daughter a better education than I had. I can't make that kind of money living in the sticks but if I was singke with no kids then I would love to
The price of freedom is eternal vigilance.
Agreed, but a State's firearm laws say a lot about the general level of freedom and opportunity in that State. Plus it may also somewhat dictate your safety in that State. Don't you wonder what would happen in the South side of Chicago if a bunch of those people were allowed to either concealed carry or open carry?
I don't need No stinking signature.
I was never given a pin #. I got my license 4 years ago. Its not a huge deal but it sure pissed me off saturday night!
Thanks for the heads up mountainman. I will look into it asap! I got my pin today so the governor will be mine!!!!!!
Man I'm glad the only PIN # I need is for my debit card on purchase.
Sounds like Massivetwosh1ts is not a place I would want to visit let alone live. and I thought the Pats was reason enough to not want to go.
The tree of liberty must be refreshed from time to time with the blood of patriots and tyrants. Thomas Jefferson
It's not THAT bad ....... but its getting there ...... sales tax is 6.25%


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I am an ambitions character artiest with plans to graduate with my Bachelor degree in 2010. I am a very determined, strong willed hard worker with big plans. After I graduate I plan to continue working where I am, while starting my own business.
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Blue Ribbon News
When math gets a little tricky for your child…
Blue Ribbon News
ROCKWALL, TX (Jan. 27, 2015) One of my favorite things to do when working with a child that has reached a point of frustration, fear or boredom with math is to take a break and do a little "Mathemagic." I will hide the answer to an addition problem on a piece ...
To Infinity and Beyond: the mathemagic legend of Srinivasa Ramanujan
The New Indian Express
The Ramanujan Museum and Math Education Centre in Royapuram organized a function on Sunday morning to celebrate the 127th Birth Anniversary of mathematician Ramanujan. Addressing a gathering of children and their parents at the event, Mayor ...
and more »
MATHEMAGIC, PETER PAN and More Set for Children, Young Adult Lineup at ...
Broadway World
The Paramount Theatre, 23 E. Galena Boulevard in downtown Aurora, Illinois, invites families, schools, scout troops, daycare centers and kids' clubs to enjoy an affordable, entertaining and educational live theater experience at any of its 2013-14 family ...
What if Disney villains all won their respective movies?
Such scenarios have been realized by Justin McTwisp in this series of portraits of Disney films gone tremendously awry. Will there be a gruesome portrait of Donald Duck getting devoured by some feral integers in Mathemagic Land? Only time will tell.
and more »
Mathemagic of love
Chandigarh Tribune
Mathemagic of love. Looking for a perfect lover? Mathematics could be the answer. Catherine Townsend meets a woman who believes in a link between numbers and love. A mathematician, Clio Cresswell, PhD, believes the answers to some of the big ...
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Don't Know Much about the Bible
Bringing to life the world of the Old and New Testaments, the acclaimed creator of the bestselling Don't Know Much About® series transforms dry, difficult reading into colorful and realistic accounts. Relying on new research and improved translations, Kenneth C. Davis uncovers some amazing questions and contradictions about what the Bible really says:
•Jericho's walls may have tumbled down because the city lies on a fault line.
•Moses never parted the Red Sea.
•There was a Jesus, but he wasn't born on Christmas and he probably wasn't an only child.
Don't Know Much About® the Bible entertains and astonishes, but more important, provides a much better understanding of the world's most-owned but least-understood anthology, with much more fun along the way.
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Bare copper grounding wire spider webbing in the attic.
First off let me introduce myself to the group. I just purchased my first home. It is in San Diego, Ca and it was built in 1962.
I opened up some of the outlets in the bedrooms and noticed that there is no grounding wire in the romex, just a hot and neutral. When going to the kitchen, I noticed that the boxes were metal and there was bare copper grounding wire connected to the box, not coming out of the romex it was a separate bare copper wire. Well I traced this wire up to the attic and found a spider web of bare copper wire. It seems as though certain boxes are grounded and others are not for example I believe the bathrooms and kitchen are but the bedrooms and living rooms are not.
The breaker box does not have a grounding box, it seems that all the grounding wires are going into the neutral bar.
So my first question is, if I wanted to ground some of the other outlets in the house can I simply run a bare ground copper wire up from the outlet to the attic and connect it to the spider web?
I will have many other questions although I am trying to read through the forums as much as possible to not repeat questions.
Thanks in advance.
Also, if you look at one of the boxes, where the wiring enters the box, you may find the ground wire wrapped around the sheathing and bare to the clamp. The clamp is tightened and thus the box grounded. A receptacle or switch screwed into the box would also be grounded. I'm not saying it was a good way of doing it but that was one way they did it.
The ground wire is supposed to follow the other circuit conductors, even if it was added later.
This is the reason non one usually does what you have described (and it does not sound like it is installed correctly).
The added ground conductors are not allowed to take any random path.
Ok just to confirm, the bare copper wire goes up and joins the other random copper wire strands and feeds back to the box. It literally spider webs. They are not individually routed to the box they connect to one another.
So I could safely run a bare copper wire from the spiderweb down the wall and connect it directly to the outlet (not outlet box but the actual grounding spot on the outlet)?
" random copper wire strands "
To clarify, there should be no random strands if the grounding was done properly. For each circuit, you should have 1 ground. It should follow alongside the other wires in the circuit and it should connect all the way back to the panel. It should be done in a neat and workmanlike fashion and should not look like a spiderweb or any other mess. As a general rule, if you look at any electrical work and your first reaction is "What the heck is this mess!", then it probably wasn't done properly.
From your description, it doesn't sound like the retrofit was done properly. It might be "better than nothing," but not by much. The ground is a safety device that should provide an uninterrupted path for any stray current to flow immediately away from you and anything else in the house.
Bottom line - if you can access these areas from above, then you should just run all new cable instead of a just a ground. If you are fishing wires, you may as well just do it once and know it is done properly.
I would love to replace the wires, but I do not want to gut all the drywall that my wife just painted, and I know there is a reason for it but I hate the fact that people staple the wires, otherwise I could of easily pulled out old while pulling in new.
The copper wire above is not disgusting it is just that it goes up and then connects to other copper wires which then go further towards the box and they meet up with others along the way. So many outlets are actually joined together via the grounding wire even though they are not on the same circuit. Is this OK?
Sorry, brick not true. ARt 250.130(3) covers retrofitting or extending grounded receptacles on a non-grounded branch circuit. There's no requirement that the grounding conductor follow the current carrying wires. It does have to go to one of the listed items of which "a spider web of bare wires" may not meet. However if the central core of that mess is part of the bonding of the building grounding system it might be OK. Running direct back to the panel (even if the branch circuit wiring doesn't go that way) is also allowed.
No, there is no way of "testing." What you need to do is run the ground to one of the known good points. This could be the main panel or one of the points in the grounding system (typically ground rods and the incoming house water service) or the stuff that bonds them together.
And 250.130(C) does not allow a " spider web of bare copper wire" to create a grounding path
The wire has to run back to the GEC or the panel.
They may not be run to each other and then back to the panel.
For correct operation of the circuit OCD the ground need to be in close proximity to the current carrying conductors.
If a large loop area is created between the grounding conductor and the current carrying conductors OCD operation will be slowed by the inductance introduced in the circuit.


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Whose woods are these, I think I know... from Stopping By Woods on a Snowy Evening by Robert Frost. I think of this favorite poem often when passing by these woods.
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